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There are no Upcoming Shows listed for this artist.
Ontario, CA
Comedy Central Certified
Amir K
AMIR K is currently on the cast of the MTV prank show, JERKS WITH CAMERAS. Last year, Amir made his foray into film with roles in Ben Affleck's ARGO and Alexandre Aja's SITE (for Fox), where he stars as the love interest opposite Ashley Hinshaw. In addition to acting, Amir is an accomplished comedian who can often be seen headlining Los Angeles comedy venues such as The Comedy Store, Laugh Factory and The Improv. Born in Tehran, Iran and raised in Southern California, his comedy is a blend of character work, storytelling and improvisation shaped by a multi-cultural upbringing. Amir is fluent in Farsi, Spanish and is known for his incredible accents and impressions.
Amir K's Upcoming Events
Amir K's Videos
Upcoming Shows
- Thu 1.29.15 - 1.31.15 COREY HOLCOMB (SPECIAL EVENT) Buy Tickets
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- Wed 2.4.15 - 8:00 PM Andrew Steele Presents: "From the Booth to the Stage " featuring Monique Marvez Buy Tickets
- Thu 2.5.15 - 2.8.15 Damon Wayans (SPECIAL EVENT) Buy Tickets
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Our offices are closed until February 4. All orders placed will ship on Thursday, February 5.
Martha's Vineyard Sign -Blue
Marthas Vineyard Sign Living The Dream
This wooden sign is beautifully silkscreened with a distressed finish.
Martha's Vineyard sign measures 22" x 6" x 1/4"
Blue background with green and white accents.
Questions? Call 508.696.0381 or email us. Product Reviews |

subset: commoncrawl


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- » C-175 charlie brown cartoon porn NOSE WHEEL SHIMMY
Re: C-175 NOSE lesbian porn WHEEL SHIMMY
Brad, the damper probably only needs a couple of o rings and a fill with hyd fluid. I'm in Aus. so I can't help with local suppliers,
as the a/c is pretty old now the damper may also be worn here and there, but I'll bet that the main shimmy problem lies in your torque links. If you wobble them from the 3/16 centre bolt and get free play, theres is a problem, Cessna have shims for the 1/4 bolt ends, but you'll have to wing it for the middle bolt free play, depending on how bad it is.
Re: C-175 NOSE WHEEL SHIMMY
The damper only takes a few o-rings. Look in your Cessna parts manual for a break down and o-ring part numbers. They are very inexpensive, even from Cessna. Make sure you look at the rod very closely for pitting. If that's the case you can buy replacement rods too.
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The Window Cleaner
A short muisc video based on the classic song "The Window Cleaner" sung by George Formby
4.39 / 5.00 6,403 ViewsCool, front page; thanks everyone!
Short animoo made for 2D Animation class as part of the theme "everyday magic".
Made in one day in one sitting on the last day of the deadline which is probably my fastest ever. Crappy planning skills ftw! O_o I'm still pretty pleased how it turned out though.
PS. Yes, I know this isn't how the lungs, O2 and CO2 really works :)
...those poor atoms...
well i liked it but i....felt a little wierd,i never looked at breathing that way...poor atoms T.T...
Well, the animation is great, and this is a mostly good illustration of part of the oxygen cycle, but why was the bronchiole pulling the eyes out of the oxygen atom, I may be wrong but im pretty sure thats not how it really works.
Holy shi*!
I never looked at breathing like THAT!
(Stupid fuc*ing breathing)


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Matt Kemp is the best: gives a disabled fan an autographed ball … and his cap and jersey
May 7, 2013, 11:36 AM EST
Vin Scully is my Homeboy found an amazing video from the Dodgers-Giants series last weekend. The description from YouTube says the fan in it is disabled and is "fighting a tough battle." Matt Kemp came over to sign an autograph and … just watch:
Gettin' dusty in here. Pardon me for a bit.
The Wrigley Field renovation has sent a whole bunch of rats scurrying into the neighborhood
Jan 29, 2015, 3:30 PM EST
I guess it's better than snakes. Or wasps.
Quote of the Day: Rob Manfred and Jerry Reinsdorf's "f*****g cigars"
Jan 29, 2015, 2:04 PM EST
This is funny. But also insightful.
The 12th greatest GM of all time is the real "Moneyball" innovator, not Billy Beane
Jan 29, 2015, 11:30 AM EST
Brad Pitt was too young to portray him, though. Maybe Kevin Kline could've?
Rosenthal proposal: make relievers face more than one batter per appearance
Jan 29, 2015, 10:01 AM EST
He's gonna get big pushback from the LOOGY union, but is the idea a good one?
Keith Law Ranks the Farm Systems: Yay for Chicago! Boo for Detroit!
Jan 29, 2015, 7:58 AM EST
A glimpse into the future, you guys.


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World's biggest super-jumbos must be GROUNDED, say engineers after cracks are found in the wings of three Airbus A380s
- Cracks found in two Singapore Air super-jumbos, and one Qantas
- Both airlines admit cracks, but say planes are safe
- 'We can't continue to gamble with lives' - engineer
Australian aircraft engineers have called for Airbus A380 - the world's biggest passenger aircraft - to be grounded, after Singapore Airlines and Qantas found cracks in the wings of their super-jumbos.
'We can't continue to gamble with people's lives and allow those aircraft
to fly around and hope that they make it until their four-yearly
inspection,' said Steve Purvinas, secretary of the Australian Licensed Aircraft Engineers Association.
Both airlines, and Airbus, admitted that they had discovered cracks, but maintained that the aircraft were safe. In total, 67 Airbus A380s are in use worldwide, on seven airlines.The aircraft are in use by Qantas, Singapore Airlines, Emirates, Air France, Lufthansa, Korean Airlines and China Southern.
Scrutiny: Airbus' new A380 superjumbo has come under fire again, after Singapore Airlines had to shut down an engine and return a flight to Singapore yesterday
'We confirm that cracks were found on
non-critical wing attachments on a limited number of A380s,' an
Airbus spokesperson said today.
'We've traced the origin of these hairline cracks, and developed an inspection and repair procedure which can be done during routine maintenance.'
Singapore Airlines, the world's second-biggest
operates 14 A380s already and has five on order, while Qantas has taken delivery
of 10 of its order of 20 A380 aircraft.
The A380 has been in service for five years. It seats 525 passengers in a typical three-class arrangement. In total, 238 of the aircraft have been ordered by 17 airlines worldwide.
The aeroplanes are assembled in Toulouse, but parts are built across Europe, with the wings being built in Broughton, Wales.
Singapore Airlines (SIA) and Qantas Airways said on Friday they discovered cracks on the wing ribs of their Airbus A380s, but said the cracks pose no threat to safety and repairs have been carried out.
The remarks came after Airbus said on Thursday that engineers discovered minor cracks in the wings of a 'limited number' of A380s, but said the cracks were not affecting the safety of the aircraft.
'Cracks were found on a small number of wing rib feet on an Airbus A380 during inspections in the second half of last year. These pose no safety issue and repairs were carried out on the aircraft,' SIA's spokesman Nicholas Ionides said in an email.
All good: Lufthansa say it has no problems with its A380 fleet and operations continue as normal
'Repairs were subsequently carried out on a second aircraft. We have kept the relevant regulatory authorities fully informed and will be carrying out inspections and any necessary repairs on other A380s as they go in for routine checks,' he added.
Qantas separately said that 'minuscule cracking' was found in the wing ribs of the Qantas A380 being repaired in Singapore after one of its Rolls-Royce Trent 900 engines suffered a mid-air blowout in 2010.
'Investigations have found that the cracking is unrelated to the engine failure incident experienced by this aircraft in November 2010 and is not unique to Qantas. It has now been repaired,' the carrier said in a statement.
'No immediate action is required by A380 operators because the cracking presents no risk whatsoever to flight safety,' Qantas said.
A Lufthansa spokesman said: 'There is no findings on our side and we have normal operations.'
Airbus said it has traced the origin of the problem and developed an inspection and repair procedure that will be done during routine, scheduled four-year maintenance checks.
SIA, the world's second-biggest carrier by market value and the first operator of such aircraft, operates 14 A380s and has five on order, while Qantas has taken delivery of 10 of its 20 A380 aircraft on order, according to the airline's website.
Both Singapore Airlines and Qantas are using Rolls-Royce Trent 900 engines on their A380 fleets.
Origin: Multi-national
First flight: April 27, 2005
Introduction: 25 October 2007 with Singapore Airlines
Main users: Emirates, Singapore Airlines, Qantas, Lufthansa
Number built: 82
Floor space: 478 Sq m
Maximum seating: 853
Range: 9,600 miles
Origin: United States
First flight: April 29, 1988
Introduction: February 9, 1989 with Northwest Airlines
Main users: British Airways, Cathay Pacific, Korean Air, Lufthansa
Number built: 694
Floor space: 321 Sq m
Maximum seating: 660
Range: 8,823 miles
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In March 2009, Nicole Vanni signed her National Letter of Intent to play for San Francisco State.
Former Sierra High football star Nigel Malone will continue his playing career at Kansas State.
In what has been a change of events for the Sierra High boys basketball team, losing has become more common then winning for the Timberwolves, as they dropped yet another Valley Oak League contest 48-36 to host Sonora High Wednesday.
Welcome back Alysia Atkins.
The East Union Lancers had a relatively easy time taking care of the Latrop Spartans, knocking the Spartans off in Valley Oak League girls sophomore basketball with a 50-27 win Tuesday in Lathrop.
After Waterford High opened its Southern League contest with Ripon Christian focused on using the gameclock as its friend, the Knights were able to curb its effectiveness in the second, cruising to a 45-29 SL victory over Waterford Tuesday.
After reasserting themselves as the team to beat in the Valley Oak League with a victory over Weston Ranch last week, the Manteca High was able to start off things this week in style, blowing out visitingKimball 76-19 Tuesday in girls basketball action.
If the Sac-Joaquin Section girls basketball playoffs were to tip off today, the Valley Oak League would have three teams hosting first-round contests in the 16-team Division-III bracket.
RIPON - During a weekend game against crosstown rival Ripon High, the Ripon Christian girls basketball team had trouble hitting its free throws.
RIPON – In a contest that featured twice as many free throws attempts as there were minutes in the game, Ripon High used a dominant first half to cruise to a relatively easy win against the visiting Ripon Christian Knights in a non-league matchup Saturday.
Eddie Andrade is capable of getting hot at any time.
After three quarters of play, the Manteca High boys basketball team held the lead, secured the momentum and had seemingly sapped the Weston Ranch Cougars of any possibilities of overcoming their 12-point deficit. After the Cougars opened the final period on a 17-4 run, it became evident that wasn't the case.
Finishing games has been a problem for Lathrop High's boys basketball team this season.
WESTON RANCH – There seemed to be only one team poised to finish Thursday's Valley Oak League battle between the top two programs alone in first place, until the Manteca High reinvented itself in the fourth quarter for a 19-2 run to stun the Weston Ranch Cougars 67-52 for a come-from-behind girls basketball win.
Sierra High, with its top player out for undisclosed reasons, was within striking distance of four-time defending Valley Oak League girls basketball champion East Union late in the third quarter Thursday at Dalben Center.
FRESNO – Jaelen Ragsdale scored 25 points to lead four players in double figures as the Weston Ranch boys basketball team cruised to victory in the opening round of the Holiday Invitational Tournament.
East Union blew out its first four opponents by 20 or more points, including a 53-25 shelling of Ripon Christian in a Foundation Game.
In time, the Manteca High basketball team may compete with the big boys of the Sac-Joaquin Section.
Devin Nunez knows how to slam a door.
They may be young, but the Manteca Buffaloes are proving to be fast learners.
STOCKTON - The fall from grace has been sudden and swift for the Lathrop boys basketball team, but coach Nate McGrath can see the potential in all the losses.
LATHROP - Gurveen Bal hit a 3-pointer in the middle of a 14-0 second-quarter run to give the Lathrop girls basketball team the lead for good in a 34-31 win over Chavez-Stockton on Monday.
Weston Ranch brought home the third-place trophy from 37th Annual Tony Contreras Delta Queen Classic on Saturday with a 61-48 win over McNair-Stockton, and three-year Cougars starter Elisabeth Alexander received All-Tournament honors as well as the award for most points scored in the three-day affair at 71 points.
STOCKTON – It came down to one bout.
STOCKTON - Sierra's uneven effort of late was bound to catch up to the Timberwolves.
Weston Ranch mounted a late charge but came up short in a 53-50 loss to Merced in the semifinal round of the 37th Annual Tony Contreras Delta Queen Classic at Stagg High on Friday.
With intentions of challenging his team, Manteca head coach Brett Lewis sent out an email to coaches from the Bay Area and Sacramento region in the offseason to set up a nonleague game.
Elisabeth Alexander wasn't entirely satisfied with her effort Thursday in the first round of the 37th Annual Tony Contreras Delta Queen Classic at Stagg High.
STOCKTON - The Sierra High Timberwolves saw their 23-point, second-half lead dwindle down to a single point in the final seconds against Chavez Thursday.
Sierra cross country coach Mike Rosendin has been named one of the Sac-Joaquin Section's six Model Coaches of the Year.


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The location couldn't get any better. Your right on lake tahoe. The lake is literally steps away from your room. Great view. The service was good here as well. The staff were all really friendly and helpful. The downside of this place is that it's really old, and it shows. Things are falling apart. The bedspread and sheets are so... More
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Fox Run Craftsmen Non-Stick 6 Cup Fluted Muffin Pan
Fox Run Craftsmen Non-Stick 6 Cup Fluted Muffin Pan
Weights & Dimensions
Product Type: Muffin pan | Color: Grey |
Material: Steel | Number of Items Included: 1 |
Non Toxic: Yes | Non-Stick Surface: Yes |
Shape: Rectangular | Handles: No |
Lid Included: No | Stove Safe: No |
Microwave Safe: No | Dishwasher Safe: No |
Refrigerator Safe: No | Freezer Safe: No |
Maximum Temperature: 350 Fahrenheit | Recipes Included: No |
Commercial Use: No | Product Care: Hand wash and dry immediately |
Product Warranty: 5 Year warranty under normal care and use |
Still have questions about this product? We're here to help
Fox Run Craftsmen Non-Stick 6 Cup Fluted Muffin Pan
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Muffin Jessica D. from Houston, TX– Verified Buyer Nice pan - works like it should. Although it is non-stick, you make still want to prep it with your usual spray, oil, or flour. This will different help the baked good slide out easily and help ensure that clean-up is a breeze. One thing to consider - it does not use a full batch of cake mix. |
About the Manufacturer
Founded 40 years ago as a cookie cutter manufacturer, Fox Run has grown into a resource of culinary tools for every kitchen. Known primarily for bakeware and baking products, the company has one of the broadest line of products for both everyday and seasonal items including seafood tools and gadgets, barware, food prep and entertaining.Reference
Non-Stick 6 Cup Fluted Muffin Pan is also sometimes listed under the following manufacturer numbers: 4461


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Home > News > Nanotech As Disease Detector
June 21st, 2005
Nanotech As Disease Detector
Abstract: Startup Nanosphere may have a technology that can sniff out telltale markers early enough to advance treatment. The challenge: translating potential to real-life results.
Possible Futures
GS7 Graphene Sensor maybe Solution in Fight Against Cancer January 25th, 2015
Nanotechnology in Energy Applications Market Research Report 2014-2018: Radiant Insights, Inc January 15th, 2015
'Mind the gap' between atomically thin materials December 23rd, 2014
A novel method for identifying the body�s �noisiest� networks November 19th, 2014
DNA nanoswitches reveal how life's molecules connect: An accessible new way to study molecular interactions could lower cost and time associated with discovering new drugs January 30th, 2015
Made-in-Singapore rapid test kit detects dengue antibodies from saliva: IBN's MedTech innovation simplifies diagnosis of infectious diseases January 29th, 2015
Iranian Researchers Planning to Produce Edible Insulin January 28th, 2015
Nanoparticles that deliver oligonucleotide drugs into cells described in Nucleic Acid Therapeutics January 28th, 2015
Evidence mounts for quantum criticality theory: Findings bolster theory that quantum fluctuations drive strange electronic phenomena January 30th, 2015
Everything You Need To Know About Nanopesticides January 30th, 2015
Crystal light: New light-converting materials point to cheaper, more efficient solar power: University of Toronto engineers study first single crystal perovskites for new solar cell and LED applications January 30th, 2015


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Premiers gather in Ottawa to discuss trade, climate, health care
Pete Carroll says decision will be Richard Sherman's to make if baby...
Dakota Johnson thinks she looked "just like a bald alien" as a child, and...
Cartoonist Steve Nease goes all the way back to 1912 to find a suitable and...
Second H7N9 bird flu case confirmed in B.C.; husband of first patient
FREETOWN, Sierra Leone - The first British citizen confirmed to be infected with the deadly Ebola disease is being evacuated from Sierra Leone on a jet sent by the Royal Air Force, a Sierra Leone official said Sunday.
The World Health Organization is also considering medical evacuation for an international health worker who has become infected in Sierra Leone, the U.N. health agency said in a statement.
Neither patient was identified by name, and the nationality of the infected WHO employee was not given.
The British patient was working at an Ebola treatment centre in eastern Sierra Leone, the region most affected by the outbreak, said Sidie Yayah Tunis, director of communications for the Sierra Leone health ministry.
The two cases highlight the risks facing health workers on the front lines of the battle against Ebola, which has killed more than 1,400 people across West Africa, according to the latest WHO figures.
"This is the first time someone working under the aegis of WHO has fallen ill with the disease," the WHO said in its statement, adding that more than 225 health workers have been infected and nearly 130 have died from Ebola during the current outbreak.
The British patient was transported via ambulance to Sierra Leone's main airport in the town of Lungi, Tunis said.
Britain's Department of Health said the patient was being flown on a specially equipped RAF transport plane to Northolt air base in London.
He will be treated at London's Royal Free Hospital, which has an isolation unit for infectious disease.
The department said in a statement that the patient "is not currently seriously unwell."
The World Health Organization says Sierra Leone has recorded 910 Ebola cases and 392 deaths. The Sierra Leone government says there have been 881 cases and 333 deaths. In Kenema, where the Briton was working, the government has recorded 303 cases.
A total of 2,615 infections and 1,427 deaths have been recorded in the Ebola outbreak now hitting West Africa, according to figures released Friday by the World Health Organization.
The Nigerian Medical Association said Sunday it has suspended a public sector doctors strike to help efforts to contain Ebola in the country.
The association directed doctors to return to work Monday while negotiations with the government continue. The strike started on July 1, before Liberian-American Patrick Sawyer flew into Nigeria and introduced the virus in Lagos, the commercial capital. Nigeria's government says the country has 14 confirmed cases, which include Sawyer. The World Health Organization on Friday recorded 16 cases in the country, saying 12 have been confirmed and there are four suspected.
The association also demanded the government restart a residency training program it suspended on Aug. 13.
Nigerian Health Minister Onyebuchi Chukwu had said earlier this month while the strike was putting Nigeria at a disadvantage, it hadn't affected the containment efforts. The government has been appealing to doctors to return to work to help contain the virus, and has been asking volunteers to join in the efforts, including contact tracing of people under surveillance.
Five people in Nigeria have died of the virus, while five recovered and were discharged from hospital, according to the government. The other four cases are receiving treatment in isolation in Lagos. As of Friday, the minister said 213 people, who were contacts of those who had tested positive for the virus, were under surveillance and are being monitored.
In Liberia on Saturday, hundreds of people lined up outside the capital's largest slum to bring food to relatives stuck inside after officials slapped a blockade on it this week. The slum, West Point, is home to at least 50,000 people. The government says the blockade is necessary to prevent the spread of Ebola but residents are worried about food shortages. They say rice distributed by the government has been insufficient and of poor quality.
Liberia has recorded 1,082 Ebola cases and 624 deaths, according to the WHO.
Two Americans and a Spanish medical worker have already been evacuated from Liberia and given ZMapp, an experimental and unproven treatment for Ebola. The Americans have recovered and been discharged while the Spaniard died.
The drug supply is now exhausted, the U.S. manufacturer has said.
The Philippine government said Sunday that it was preparing to carry out a mandatory evacuation of Filipinos in three West African countries due to the Ebola outbreak.
Department of Foreign Affairs spokesman Charles Jose said in Manila that there were 1,979 Filipinos in Sierra Leone, 880 in Guinea and 632 in Liberia, including 148 U.N. peacekeepers. Jose did not give a date but said the repatriation of the Filipino workers and their dependents would be carried out "very soon."
Associated Press writer Jill Lawless in London and Jim Gomez in Manila, Philippines contributed to this report.
By Clarence Roy-MacAulay, The Associated Press
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The water-based aerosol provides quick knockdown of bed bugs, mites, ants and roaches.
TWINSBURG, Ohio — JT Eaton Kills Bed Bugs Plus is an aerosol spray that provides quick knockdown of bed bugs, mites, ants and roaches. The water-based aerosol provides up to a 12-week residual, according to the manufacturer.
Kills Bed Bugs Plus are 17.5-ounce aerosol cans that come packaged 6 cans per case.
The product is available from distributors as of June 1, 2013. For more information visit www.jteaton.com.
The FDA is considering whether to approve the experimental use of genetically modified mosquitoes in the Florida Keys to help stop the spread of dengue fever and other diseases.
The company, formerly Arrow Environmental Holdings, closed seven merger deals in December.
Forty new franchisees attended training at the Mosquito Joe headquarters in Virginia Beach, Va.
The Techni-Baiter baiting system is a product that service professionals can use to save on bending and kneeling.
James Willix of Viking Pest Control, Bridgewater, N.J., recently earned Associate Certified Entomologist status from the Entomological Society of America.


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Music & Me: Alison Mosshart of The Kills
The first record I bought was…
I don't honestly remember. There was no place to buy records where I was living, so I used to tape songs off the radio and listen to them on my Walkman.
The first gig I went to was…
A band called Dirty Poodle at a skate park in Melbourne, Florida.The singer was a guy called Scott Becky. He used to paint his fingernails blue and play surfy guitar. His lyrics were surreal, about animals and things catching fire.Once he wrote down his address for me so we could write letters. Next to the address he drew a picture of his house, his car, the fence, a rooster on the front lawn. There was so much information.
Myfavourite album is…
Ice Cream For Crowby, Captain Beefheart.
But my parents always liked…
I didn't know what they liked. They never listened to music, but recently I was home digging through some stuff and I found my dad's record collection. He had a lot of Rolling Stones and Pink Floyd and stuff like that.
I couldn't marry someone who liked…
Avril Lavigne.
On stage I like to wear…
Jeans andT-shirts, capes with horses and lightning, Indian ponchos, gold boots… whatever I fancy that night.
I'd love to perform with…
Don Van Vliet [aka Captain Beefheart], him just talking and talking down the microphone the way he does, real slow and cool.
One thing that must change in the music industry is…
The music industry itself. There's very little soul or art left in it. Real artists are seen as a total risk, because they can't be moulded. I try to keep out of it, mentally and emotionally, as much as I can.
A great album cover is…
Captain Beefheart, Trout Mask Replica. That's a real dead fish head on Don's face. He said it had a really terrible smell.
On my iPod I listen most to…
Again, all the Beefheart records because his voice is so sincere and his lyrics are so bizarre. And I've been listening to Moondog's The Viking Of Sixth Avenue just as much for his lack of lyrics. Also, a lot of Townes Van Zandt.
If I could have written any song it would have been…
"Waiting Around To Die" by Townes Van Zandt or "Do You Like Me?" by Fugazi.
The worst song I've heard is…
Anything by Paula Abdul or New Kids OnThe Block. This list could easily be endless.
The Kills' new single 'Last Day Of Magic' is out now on Domino. www.the kills.tv/
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Favorite films
Recent activity
All filmsRecent reviews
Despicable Me 2 2013
Ok, it's official...I fucking hate the Minions.
Despite absolutely adoring the first film when I saw it around 3 years ago, I never had much interest in seeing the sequel so I never did. Then, I just happened to come across the original film on tv tonight and though I didn't "adore it" like I did years ago, I still found it to be really fun. I didn't even mind the Minions, which had also grown weary on me a…
Despicable Me 2010
The Despicable Minions are literally the Ewoks of this generation.
Both were made solely to appeal to kids and make kids want to buy every little toy they can get their hands on. They were made to look and act as cutesy as possible. The Ewoks even got their own movie and the Minions have their movie coming out later this year. In fact, the Ewoks got TWO movies so if my parallels are correct, then Minions might get a…
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The Dark Knight 2008
I'll admit, I'm not gonna lie. I was REALLY scared to revisit this again. This really got me into film. It's not the film that started my love for film, but it's the first film that made me say "I wanna go into the film industry" so it's really close to me. I've seen this countless times but I noticed that for many people, it does'nt hold up well today so I was really scared to revisit it. Thankfully, I…


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Harper Collins £18.99
Picture book review: My Brother's Book, By Maurice Sendak
'Goodbye, my brother,' the old master said
Maurice Sendak, America's foremost children's illustrator, died last year at the age of 83. Sickly and frequently bedridden when young, he later described his Brooklyn childhood as "that terrible time". Subject to the detested attentions of various visiting relations, whom he later transformed into the monsters in Where the Wild Things Are, he spent long hours watching healthier children play outside. But there were pleasures too – in particular reading comics, and illustrating the stories written by his older brother Jack.
This last picture book is the artist's farewell to that same brother, a far more occasional children's writer, who died in 1995. Written shortly after the event, Sendak only added the illustrations when he knew his own time was short. It starts with two brothers, Jack and Guy, sharing the same dream, and ends with each enfolded in the other's arms. A series of tangled and obscure adventures in between is framed by references to The Winter's Tale. This play's theme of loss and eventual reunion was especially poignant for Sendak in old age, grieving both for his brother and for Dr Eugene Glynn, his psychoanalyst partner of 50 years, who died in 2007.
Abandoning the ferocious cross-hatching found in his earlier work, Sendak this time turned to watercolours, better suited to an increasingly shaky hand and fading sight. The end results are reminiscent of his hero William Blake, and new ground for an artist still capable of springing surprises. Familiar Sendak characters also appear, from naked youths – attacked in previous picture books by mean-minded critics as "inappropriate" – to a vast bear who shows his affection by wanting to eat whoever he is talking to.
Love and menace were often linked in Sendak's imagination, along with the idea of finally arriving at a safe haven, but only after surviving perils along the way.
With both text and illustrations packed with images that defy easy understanding, this book offers a journey into an extraordinary imagination. Not really designed to be read through at one sitting, it is directed more towards a child's intuitive acceptance of how the everyday can walk hand in hand with the surreal. Each re-reading reveals something new as the old master bids adieu, not just to the brother who meant so much to him but to all his readers as well.
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JACKSON, Miss. (AP) — The state Health Department this week conducted an unannounced inspection of Mississippi's only abortion clinic to see if it's complying with a 2012 state law that eventually could put it out of business.
Findings from the Wednesday inspection aren't being released to the public yet, but clinic owner Diane Derzis said last week that her Jackson Women's Health Organization had been unable to meet the law's requirements.
Meanwhile, the clinic remains open as it goes through a lengthy process that's set out in a separate a state law governing administrative procedures.
Health Department spokeswoman Liz Sharlot said Friday that it is standard practice for findings of an inspection to be given first to any facility the department examines, whether it's a clinic, hospital, restaurant or day care center. The findings would later be made public.
"They got treated the same way as any other facility we license," Sharlot told The Associated Press.
Derzis has said the clinic missed a Jan. 11 deadline to comply with a law requiring every person doing abortion there to be an OB-GYN with privileges to admit patients to a local hospital. She said the three physicians who do most of the abortions at the clinic applied for privileges at several Jackson-area hospitals, but did not receive them.
Admitting privileges can be difficult to obtain, either because hospitals won't grant them to out-of-state physicians or because religious-affiliated hospitals might not want to be associated with physicians who do elective abortions.
The missed Jan. 11 deadline triggered the health department inspection. Findings from the inspection are being sent to the clinic by certified mail, Sharlot said.
If the clinic is found out of compliance, it has 10 days after it receives the letter to ask the health department for an administrative hearing. A hearing could be scheduled within a few weeks, Sharlot said.
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STANFORD, Calif. — David Shaw has no plans for Stanford to be down on its Luck once star quarterback Andrew departs for the NFL.
Shaw gets the same question in a variety of forms: Will his Cardinal possibly stay put as a top-tier team once projected No. 1 pick Luck is long gone?
Shaw is optimistic he can keep a good thing going, and the ever-positive Luck doesn't foresee a drop-off for the No. 4 Cardinal (11-1), either.
Shaw, for one, looks at Monday's Fiesta Bowl date with third-ranked Oklahoma State (11-1) not as the program's last hurrah on college football's big stage but rather just another great opportunity to keep building the Stanford name.
A win over Oklahoma State and the Cardinal would match their 12-1 record from last season.
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A ''man cave'' went up in flames in Blenheim early this morning.
Firefighters were called to a 30 square metre shed at Battys Rd, south of the intersection with Lakings Rd, just before 6am.
Blenheim deputy chief fire officer Dion Partridge said the shed, which doubled as a man cave and games room, was completely gutted.
Firefighters managed to contain the blaze but the heat from the shed spread to the main house, causing superficial damage to the weatherboard exterior, Partridge said.
No one had been in the shed at the time of the fire, he said.
About 20 volunteer firefighters and five fire trucks from Blenheim, Woodbourne and Renwick attended the blaze.
It is believed the fire started on a couch in the shed, however the cause was still being investigated, he said.
At least four men, a woman and a toddler lived on the property.
A woman, who lived in the area, said her partner called the fire brigade after he saw the flames as he was leaving for work about 5.45am.
The woman said she saw people coming out of the main house and going back inside to retrieve things.''I was yelling get out of there, the shed will go,'' she said.
The mother and her young daughter, along with other people from the house, made it out safely before firefighters arrived.
The woman believed the four men who lived at the house worked at a vineyard in Marlborough.
- Nelson
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High water and sand ingress has coerced Reliance Industries (RIL) to close its seventh well on KG-D6 gas block. The company now awaits regulatory nod to carry out urgent work over to plug the problem responsible for drastic fall in output. The output of D1&D3 fields, after shutting the seventh well, has now declined to 19.02 million standard cubic meters per day from about 20 mmscmd a month ago. RIL, on November 29, due to same reason, had shut well B4 on the main producing fields of Dhirubhai-1 and 3 (D1&D3) in KG-D6 block. D1&D3 are producing less than 22 mmscmd of gas, down from 53-54 mmscmd achieved in March 2010.
Tata Motors' wholly owned subsidiary Jaguar Land Rover (JLR) has reported 14% increase in its global sales in November at 29,893 units, helped by continued demand for the Evoque SUV. November sales increased in almost every major market with sales growing in China by 43%, Asia Pacific by 26%, the UK by 15% and Europe by 12%. For the January-November period, JLR's combined sales increased 32% to 324,184 units. Recently, JLR has rolled out its all new version of sports utility vehicle - Range Rover - with price starting from Rs 1.72 crore. The new Range Rover will be available in both petrol and diesel options, while depending on specifications and variants the price of the new Range Rover can go up to Rs 1.9 crore.
The coal ministry is likely to move a cabinet note seeking permission for Coal India (CIL) to extract coal bed methane (CBM) in its leasehold areas. The development follows a request by Kolkata-based Coal India that instead of auctioning new CBM blocks in its leasehold areas, the petroleum ministry should allow the miner to explore and produce the CBM on its own or through exploration companies it chooses. Coal India has been facing operational and safety problems in the CBM blocks that were earlier auctioned by the ministry. The coal ministry, the petroleum ministry and the Planning Commission have agreed in principle to the suggestion. At present, companies such as GEECL and ONGC are exploring and extracting CBM from blocks falling in areas under Coal India's jurisdiction.
Jet Airways has announced a convenient payment option for its customer which allows them to book tickets online on the domestic carrier's portal and pay by cash later, a move aimed at enhancing the airline's distribution network. The latest offering cash on delivery is available only for those customers who book their tickets through the Jet Airways' website. The airline has tied-up with the Hyderabad-based cash collection solutions provider GharPay to deliver the service. Guests selecting the cash-on-delivery option while booking their tickets online will be contacted by GharPay to confirm the time and location for collecting the payment. Once the payment is collected, the e-ticket will be automatically sent to the guest's email address. The scheme has been made available across 16 cities pan-India covering over 900 postal codes and will be available in additional cities, which include places like Faridabad, Ghaziabad, Gurgaon, Noida, Navi Mumbai, Thane, Visakhapatnam.
ICICI Bank has opened 101 rural branches across six states as part of its financial inclusion plan that aims at providing banking services in unbanked villages. These branches have been opened in small villages, which were so far devoid of any banking facility. These 'Gramin' branches will offer all the basic banking services such as savings bank account, fixed and recurring deposit, remittances, Kisan Credit Card, credit cards and tractor loans. These branches were formally inaugurated in 19 districts across the states of Rajasthan, Andhra Pradesh, Gujarat, Maharashtra, Madhya Pradesh and Tamil Nadu. The country's largest private sector bank has also opened close to 2 million 'no frill' savings accounts this year taking the total number to around 12 million 'no frills' accounts, which is a key part of financial inclusion strategy.
Paints major Berger Paints (BPL) aims to become a Rs 7,000 crore company in the next four years. Berger is planning to enhance its production capacity to 34,000 tonne per month from 20,000 tonne a month by mid-2013. Meanwhile, Berger has also announced its association with designer Sussanne Roshan, wife of actor Hrithik Roshan, for Lewis Berger Design Stories concept. The company will have 40 studios inside existing stores across the city to showcase the concept that aims to offer designer themes in paints long with furnishing and furniture. The company is also setting up an industrial paints facility near Pune at a cost of Rs 15-20 crore.
Sanwaria Agro Oils plans to enter the consumer goods space by launching basmati rice, breakfast products and snack foods by next year. The company's focus will be to largely on health conscious food products. To begin with, the Bhopal based firm has launched 'Sanwaria Salt' to be sold in Madhya Pradesh and Chhattisgarh initially. The company is in talks with retailers including Bharti Wal-Mart for listing its FMCG range of products. The company set up in 1991, is part of the Sanwariya group, which has presence in sectors including agro food, energy and infrastructure.
Moser Baer's arm - Moser Baer Projects has received the final approval from the Central Electricity Authority (CEA) for its 120 MW Miyar hydro plant in Himachal Pradesh and construction is expected to start in April next year. An integrated power company, Moser Baer Projects (MBPPL) has interests in solar, hydro and thermal generation areas, among others. CEA, the nodal agency for planning activities in the power sector, has consented to issue Technical Concurrence (TC) for the project. The project, having three units of 40 MW capacity each, is coming up at Lahaul in Himachal Pradesh.
Aanjaneya Lifecare, an emerging integrated pharma company on an international scale with an audience representing the international business community, has bagged two prestigious awards by being ranked No 2 Industry wise and 9th Position in Asia- Pacific region at The Global Investor Relations (GIR) Summit Coordinated by KPMG and MZ associates. The GIR Summit was held at New York in USA. The other awardees from India include Infosys and Essar Oil amongst others. Aanjaneya Lifecare is a leading research based integrated pharmaceutical company with established research, manufacturing and marketing capabilities. It is R&D focused, has a multi product portfolio with state of the art manufacturing facilities, and is set to become a marketing conglomerate across the globe. It has a WHO GMP approved facilities for manufacturing bulk drugs at Mahad and finished dosage forms at Pirungut near Pune.
Reliance Industries (RIL) and Essar Energy are re-entering the fuel retailing business with aggressive growth plans and efforts to lure customers away from state-run rivals by offering discounts and benefits.......click on news to read complete article.
Rejecting Telecom Regulatory Authority of India (TRAI)'s recommendations, the Telecom Commission (TC) approved a base price of Rs 3,705 crore for each MHz of 2,100-MHz spectrum, which would be auctioned......click on news to read complete article.
To take on its public sector peers in the fuel retailing segment, Mukesh Ambani-controlled Reliance Industries (RIL) plans to leverage technology. RIL and Essar Oil face government-owned Indian Oil Corporation......click on news to read complete article.
Snapping four days gaining streak, the US markets closed mostly lower on Friday as investors opted to book some profits off the table following the recent upward move, which came amid......click on news to read complete article.
The US markets closed higher on Thursday, as traders reacted positively to the European Central Bank's highly anticipated decision to implement quantitative easing. Federal Reserve officials are currently......click on news to read complete article.
The US markets closed modestly higher on Wednesday, extending its winning streak to three sessions, as investors widely expect the European Central Bank to deliver on monetary stimulus at its key meeting.......click on news to read complete article.


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After going M.I.A. for the better part of two days, UFC 183 main eventer Nick Diaz finally makes his way to Las Vegas to fight Anderson Silva.
The Ultimate Fighting Championship on Wednesday announced its inaugural
ONE FC's 2015 schedule is starting to come together
UFC president Dana White on Wednesday said that they
I dont see Diaz being able to knockout or submit BJ Penn. I actually see BJ winning by ground n pound. YOU HEARD IT HERE…
Penn by ground and pound. Huh. Well you really went out on a limb there. Lol
I haven't checked the betting odds, but I would assume that's the most Likely outcome.
If its not Ill be putting my money there.
Hahahaa…ground and pound..good stuff. You think that BJ is going to put Nick Diaz on his back and punch him until he is knocked out eh? What about the fact that Diaz has finished more fights from his back via submissions than almost any other mma fighter? What about the fact he doesn't get KO'd? What about his unbelievable stamina? Yeah I'm going to guess that Penn gets submitted in the third or loses by Unanimous Decision. Bet on it.


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Stinky Tofu
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CINAR Animation, Sesame Workshop, CinéGroupe Canada
Holly Gauthier-Frankel, Rick Jones, Jesse Vinet, Oliver Grainger, Ellen David, Arthur Holden, Neil Shee, Sonja Ball, Khaira Ledeyo; Full Voice Cast ..
Joseph Jacques
Andrew Chappell, Kevin Currie, Venetsy Vesilnov, Amy Tan
- 2001
- CINAR Animation, Sesame Workshop, CinéGroupe Canada
- Sagwa, The Chinese Siamese Cat Episode Guide
- Cartoon Characters: Sagwa, Fu-Fu, Sheegwa, Dongwa, Mama Miao, Baba Miao, Yeh-Yeh, Nai-Nai, Tai-Tai The Three Sisters, Foolish Magistrate, Cook, Reader.
- Vocal Talent: Holly Gauthier-Frankel (Sagwa), Rick Jones (Fu-Fu), Jesse Vinet (Sheegwa), Oliver Grainger (Dongwa), Ellen David (Mama Miao), Arthur Holden (Baba Miao), Neil Shee (Yeh-Yeh), Sonja Ball (Nai-Nai), Khaira Ledeyo (Tai-Tai), Hiro Kanagawa (Magistrate), Raugi Yu (Cook), Russell Yuen (Reader).
- Directed By Joseph Jacques.
- Written By Andrew Chappell.
Story: Kevin Currie, Venetsy Vesilnov.
Based On The Original Children's Book, "Sagwa" by: Amy Tan.
Additional Crew:
- Created by: Amy Tan.
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Cartoon Summary:
Sagwa loves to hear her grandfather's stories, but she can't stand his stinky tofu breath. She learns that it is better to tell him the truth than to miss spending time with him.
Cartoon Comments:
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With a poor start to the new year a big turnaround was dearly needed. It was established early in the morning by the inspirational skipper, Shayne 'Rin' Lin, that our attitude was simply not good enough. With that in mind the lads took to the warm up with intensity that looked like a winning outfit.
Stan Gaynor... this shot was similar to his first for Gordon, down at Balmoral. The webmaster dropped him in his fantasy team immediately
Due to our dismal batting display on our last hit at Killara, Shayne was a bit unsure whether to bat or bowl on what looked like a good batting deck. Fortunately Shayne didn't have to make a decision, as is the trend this season he lost the toss and the opposition elected to bat.
Sam Watts was absolutely terrific with the ball opening up. 2 wickets in three balls gave us more to cheer about than we have since the New Year. This was essential in setting the tone in our fielding effort. Sam was practically unplayable in his first spell and was well supported by Matt.
This set a perfect platform for the young Dylan Hood on debut in 4's to execute his skills and continue the pressure created by the opening bowlers. Generally pressure and tightening up runs leads to wickets. This was no exception but not without some magic. Iqbal "magic fingers" Ahmed was the wizard that executed one of the catches of the season.
Kleem, without the trademark red helmet, but in a good vein of form
A thick edge raced to the big man, with a slight movement to the left he stuck out his right hand and he never looked like dropping it. This shifted momentum on our side and throughout our entire innings we were exceptional in the field; lead by Lez "pineapple head" Leighton.
Ben deserves plenty of credit for Gordons energy and talk in the field. Ben and Iqbal bowled very well in patnerships managing to keep the runs down. Randy-Petes were tracking towards a total below 200, however some fine power hitting from one of their youngsters threatened to build a total far greater than that.
Fortunately Sam Watts couldn't put a foot wrong at the death and managed to pick up more wickets and keep the runs down. Sam ended up with a 5 for and deservedly so.
Gordon were set a total of 212 and with our recent run of things we thought 212 could be a competitive total. However all of us were wrong.
Sam Watts sets his side up for the win
212 was far too little for the class of Gordons top 3 (as that's all it took). Mitch Kleem was clearly excited about his recent texts from a new friend he made in the Philippines. She/He would be very proud as he smoked his way to 41 and laid an excellent platform. Unfortunately whilst thinking about the photo "they" sent, Stan took a run that was a bit too risky and he was run out.
The fall of wicket bought Saahil to the crease. The pair capitalised on the great start and took the game away from the opposition. Both played some excellent shots and made it look far too easy.
Stan and Saahil batted till the end and scored 75* and 68*. It was a wonderful all round performance. Let's take this momentum to the next match and see where the season takes us!


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Trumpet: Antoine Courtois Evolution III Mthpc: Yamaha Allen Vizzutti
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RPG » Raid of Ryugu-Jo RP
-Thank you! I also love your clothes!- The Half Banshee held Hitomi hands tightly, yet her cheerful demeanor was a façade to hide the turmoil inside her, just a glance of her eyes, almost demented was more than enough to notice. –If you say they need I won't be late- She then turned to the others and barked orders with a broken voice, that shift from high to low pitch without rhyme or reason, her fingers went white from the pressure she was using on Hitomi's hand. –yOu InSeCtS!!! dO wHaTeVeR mIsS hItOmI aSkS oF yOu!!!! fAsT! –
Some glasses and fragile objects still vibrated after her shouts, all the Western MS moved almost in a mad rush to form a line in front of Hitomi, as Houzi managed to explain the plan while the Seamstress played her hand skillfully and managed to distract the deranged Ciara. –I'll go to pick some more of my clothes, for the trip to the surface. - The Banshee spoke with a cheery and sing-song tone and then jumped and skipped towards the stairs.
As the Westerners lined up for the Kaspa, Houzi went near her and bowed. –I'm amazed at your resourcefulness Miss Hitomi, please take care of them, I'll try to check the Lobby, I hope is not too late to help my brothers and sister. – And with that he left, leaving the Oni Brothers protecting Hitomi. The Monkey King hoped that the fight wasn't over.
-Nice try fattie, but you lack power to face my majestic machine! - As effective as Hal dash bash could be on others objects, this time around his offensive power was consumed by the Core of the Armor, almost as if it absorbed the energy and aggression behind it, Eastern Lion returned the favor with a massive discharge of energy aimed at Hal in a wide area. Meanwhile Ghoul, with a psychotic smirk in his face, and Phantom were aiming for the Round Speedster, thinking they were free, as the blast from Lion had knocked them off their feet.
Yet the Killers underestimated the willpower of the MS trio. –We cannot be defeat like this!- Kobushi roared as he tackled Phantom, burning his skin with the fiery aura around his target, but not letting go. –I promised Hitomi-chan to go to the surface!- A blast of silver energy came out from Ginari hands, pushing Ghoul into a nearby wall, that still melted from the Spectral Flames caught him and sticked to him, this obviously ended with him screaming in pain. –And we need to open a path for our brothers and sisters! A path for tomorrow!-
Sasuke rushed with wind propelling him and blades of wind coming from his forearm, he slashed the energy attack launched towards Hal in Mid Air and landed protecting the Speedester with a wind barrier. –Thanks for you help Hal-san, we needed a respite, but we can do it on our own from now on, go and protect Hito..*CRACK*- As the half Kamaitachi talked, looking at Hal, the arm of Eastern Lion shot forward tied to metallic string and hit the young MS right in the head, breaking his neck leaving his lifeless eyes looking at the Speedster from a slanted angle, before his body fell into the floor.
Both Kobushi and Ginari were horrified. That granted Phantom enough space to escape from the grasp of the Half Asura and cleaving his axe on his head. The Veteran Myth Soldier had a second of surprised pain before being set on flames and turning into ash. The Half Kitsune fell on her knees crying, feeling so useless. –I-I couldn't help…I-I f-failed….sorry… - Ginari started sobbing but somebody whispered in her ear. –Shhhhh, don't cry love, you will be meeting them. - Ghoul was right beside her, having escaped the burning embrace of the metallic wall. Most of his clothing was burnt, yet his body remained intact. –Fattie, I think you're alone, mind if we gut you open?- Ghoul spoke while walking towards Hal, with a creepy look on his eyes and moving his head from side to side, almost as if he was mimicking a snake.


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US 5234450 A Abstract A catheter-cutter for aorto-coronary bypass graft cutting of vein valves within a vein graft and for the in-situ bypass vein graft cutting of the valves within a vein includes at-least-one arcuate, razor-sharp, angled-tip cutting blade extending from the open distal end of the catheter, such at-least-one cutting blade being fixed or selectively extendable from the distal end of the catheter by optional control means carried at the proximal port of the catheter, the at-least-one cutting blade being effective to cleanly excise and clearly cut a valve, not merely rendering it relatively incompetent as present valvulotomes do. The catheter according to this invention may carry a fiberoptic viewer for observing the cutting process. A selectively inflatable balloon member may be provided about the catheter tube at its very distal end to accurately fix the position of the at-least-one cutting blade and, also, to act as a buffer, if desired, during catheter insertion and manipulation while being negotiated in a forward direction within the vein being modified.
Claims(10) 1. A valvulotome flexible elongate catheter including:
an outer cylindrical wall; an inner cylindrical wall, means supporting said cylindrical inner wall in said cylindrical outer wall so that the inner wall is cylindrically spaced from said outer cylindrical wall to form at-least-one arcuate blade element chamber between said inner and outer walls; at-least-one blade element supported in said at-least-one blade element chamber and having a body portion and a cutting tip portion; said body portion being arcuate in transverse cross section; said cutting tip portion being directed inwardly toward the longitudinal axis and terminating in a razor-sharp cutting edge; and means for fixing said at-least-one arcuate blade element in a fixed longitudinal position in said catheter and in a fixed radial position in said catheter. 2. A valvulotome flexible elongate catheter including:
an outer cylindrical wall; an inner cylindrical wall, means supporting said cylindrical inner wall in said cylindrical outer wall so that the inner wall is cylindrically spaced from said outer cylindrical wall to form at-least-one arcuate blade element chamber between said inner and outer walls; at-least-one blade element supported in said at-least-one blade element chamber in a fixed position and having a body portion and a cutting tip portion; said body portion being arcuate in transverse cross section; said cutting tip portion being directed inwardly toward the longitudinal axis and terminating in a razor-sharp cutting edge, said chamber forming a single lumen. 3. A valvulotome catheter, including:
a tube having an outer wall having a distal end and a proximal portion; a rotatable end portion supported at said distal end; a pair of inwardly directed cutting blades mounted in a fixed position in said rotatable end portion, each blade having an inwardly directed razor-sharp terminating end, and each blade being fixedly supported in said rotatable end portion to rotate therewith; a shaft extending from said rotatable end portion to said proximal portion of said catheter; and, rotating means mechanically coupled to said shaft at the proximal portion thereof to cause rotation thereof and of said rotatable end portion. 4. A valvulotome flexible elongate catheter including:
an outer cylindrical wall; an inner cylindrical wall, means supporting said cylindrical inner wall in said cylindrical outer wall so that the inner wall is cylindrically spaced from said outer cylindrical wall to form at-least-one arcuate blade element chamber between said inner and outer walls; at-least-one blade element supported in said at-least-one blade element chamber and having a body portion and a cutting tip portion; said body portion being arcuate in transverse cross section; said cutting tip portion being directed inwardly toward the longitudinal axis and terminating in an inwardly directed razor-sharp cutting edge; and said body portion being continuous to form a complete single circular cutting edge and being fixed in longitudinal position within said catheter. 5. A valvulotome catheter including:
a cylindrical flexible elongate tube having a longitudinal axis, a radial axis and an outer wall and an inner wall; at least one blade and means attached to said cylindrical tube for supporting said blade in a position spaced inwardly toward the longitudinal axis away from the outer wall, said blade being arcuate in cross section and having a body portion and a cutting tip portion, said cutting tip portion being directed radially inwardly and terminating in a razor sharp cutting edge. 6. Apparatus according to claim 5 wherein said at-least-one arcuate blade is fixed longitudinally with respect to said outer wall.
7. In a catheter for removing valves in a vein, a flexible cylindrical elongate member having a longitudinal axis and having an outer cylindrical wall, said flexible cylindrical elongate member having proximal and distal extremities, said distal extremity having a free end, a blade which is arcuate in cross section, means attached to said flexible cylindrical elongate member for supporting said blade in said flexible cylindrical elongate member so that it is adapted to protrude from the free end and in a position spaced inwardly towards the longitudinal axis and away from the outer cylindrical wall, said blade having a forwardly extending cutting edge, said flexible cylindrical elongate member having sufficient rigidity so that the distal extremity can be advanced and rotated by advancement and rotation of the proximal extremity to cause the blade to excise said valves in said vein while said flexible cylindrical elongate member is disposed in said vein.
8. A catheter as in claim 7 wherein said flexible cylindrical elongate member has a lumen therein and wherein a fiber optic bundle is disposed in said lumen and extends to the distal extremity of the flexible cylindrical elongate member.
9. A catheter as in claim 7 together with a low profile inflatable balloon mounted on the outer wall of the distal extremity of the flexible cylindrical elongate member, said flexible cylindrical elongate member having a balloon inflation lumen therein in communication with the interior of the inflatable balloon, said balloon when inflated serving to ensure that the blade will not come into contact with the vein.
10. A catheter as in claim 7 together with means mounted on the flexible cylindrical elongate member for moving said blade between extended and retracted positions.
Description This is a division of application Ser. No. 07/386,215 filed Jul. 28, 1989, now U.S. Pat. No. 5,092,872. 1. Field of the Invention This invention relates to medical instrumentation and, more specifically, to such instrumentation applied in the field of cardiac surgery and peripheral vascular surgery. 2. Prior Art Arterial reconstruction utilizing an autologous saphenous vein is widely used in the field of peripheral vascular surgery in the lower extremities and so has become well established as the customary graft source for aorto-coronary bypass graft surgery. In peripheral vascular surgery in-situ bypass grafting has become more and more the operation of choice for bypassing the infrageniculate arteries and re-establishing arterial blood flow. The autogenous saphenous vein is historically similar to an artery and is the standard to which all other grafts are compared. The earliest experiences with venous autogenous grafts, although experimental at that time, were gained by Gluck in 1894, followed by Exner and Hopfner in 1903. In the United States, Julian, et al., Lord and Stone, Dale, et al., and Linton and Darling pioneered the wide use of an autologous vein in femoral-popliteal arterial reconstructive procedures. The concept of using the saphenous vein, in-situ, is attributed to Karl Hall, in 1959, who suggested that the saphenous vein bypass might improve if the vein were left in place and the valves were rendered incompetent. He was the first to successfully report the use of the in-situ procedure as an arterial bypass, in 1962. Further, the technique of in-situ bypass grafting was augmented by Leather and Karmody who used valve strippers to disrupt the grafted vein valves. With the increasing experience worldwide, it was apparent that the crux of the in-situ vein graft was the method of removal of the valvular obstructions to distal arterial flow. To achieve the in-situ disruption of the valves, various techniques have been used: 1. Incision of the valves by miniature scissors inserted through a venotomy proximal to the respective valve site. 2. Thin incising vein-strippers passed through the vein in the distal to the proximal direction. 3. Bullet-shaped metal strippers introduced in anterograde or retrograde directions, employing incising parts in different shapes. 4. Long, thin-shaped valvulotomes with curved, hook-like incising tips which incise the valve leaflets upon pulling the device back through the valve. 5. Double cylinder strippers having incising parts incising the valves when such parts are pulled in a reverse direction. 6. Thin incision fingers extending from the open distal end of a catheter that is being pulled from the proximal part of the vein towards its distal portion by a pulling instrument that has been secured to the catheter after being introduced through the distal part of the vein. In cardiac surgery, autologous saphenous vein grafts have been widely used since 1967 in aorto-coronary bypass grafting procedures for symptomatic coronary artery disease (CAD) treatment. Autogenous reversed saphenous vein grafting has become routine for aorto-coronary bypass surgery. With this method the saphenous vein valves are left intact and the vein is reversed. The distal portion of the grafted vein (which becomes proximal in the graft) is usually larger in diameter than the replaced coronary artery, resulting in reduced blood flow velocity in the vein graft compared with that in the coronary artery. These grafts provide an early patency rate of 98%; a routine elective mortality rate of approximately 1%; and a myocardial infarction rate of approximately 3%. The patency rate of coronary vein grafts is approximately 85% by the end of the first year postoperatively and the attrition rate continues approximately 2% per year for the next 4-5 years. Progressive stenosis continues, and the patency rate of coronary vein grafts at 3 years postoperatively is approximately 70% and approximately 60% at 5 years postoperatively. At 10 years postoperative, atherosclerosis becomes the major cause of coronary vein graft failure. The vein graft occlusion rate doubles between 5 and 10 years, postoperatively. Performance of coronary reversed saphenous vein grafts relates, among other factors, to the intact valves, which are implicated in graft failure. Studies suggest that valves do not open fully during reversed blood flow and cause a decrease in the graft blood flow rate at specific obstruction-related points. The undisrupted valves, non-collapsed against the wall of the grafted vein, may cause them to collapsed against the wall of the, grafted vein, may cause them to stay in the main blood stream and become a site of turbulence to laminar flow and an origin for thrombus formation under the cusps. This is especially true with the decreased blood flow rate in large diameter vein grafts and with poor run-off. Thrombosis may lead, in these cases, to myocardial infarction or, later, to increased stenosis and occlusion. laminar flow at the venous valves causes a reaction of the vein grafts similar to a spasm, suggesting tat the valves may be a predisposed to an increased stenosis rate and a rapid occlusion rate of the vein grafts. Additional experience evidenced that when more than one valve site was present in the body of the saphenous vein graft, occlusion, thrombus formation or accelerated progressive atherosclerosis seemed to occur in anatomic correlation to these valves. Good flow velocity is essential to the patency and integrity of coronary vein bypass grafts, while flow disturbance and decreased blood flow velocity are important influencing factors affecting their integrity as well as short term and long term patency. Bisection of vein valves significantly increases the blood flow rate through the vein grafts. Prior art devices, while rendering the saphenous veins relatively incompetent, did not remove the valves, with the result that complications such as stenosis, occlusion and thrombus formation, as previously recited, occurred. In cardiac surgery the protocol of coronary reversed vein grafts is subject to review and reversion if improved instrumentation becomes available, and is proven to be effective to enhance potency rate and integrity. Therefore, it is an object of this invention to provide a medical instrument that will overcome the general problems recited hereinbefore. It is a further object of this invention to provide an easy to operate cutting catheter that will cut and remove, effectively, the valves in the saphenous veins used as grafts for bypass peripheral surgery and aorto-coronary bypass surgery. Apparatus is provided for cutting the bi-cuspid venous valves free from the wall of a vein to be used in bypass vein graft surgery. This end is achieved by a catheter-vein cutter which comprises a cathetor having one or two arcuate (convex) tip-angle-edged razor-sharp cutting blades, positioned at its distal end tip. The catheter has one or two channel lumens. In its center or in a laterally displaced position, is a separate, shielded fiberoptic channel to provide real-time imaging control of manipulation of the catheter, manipulation of its blades and inspection of the results obtained. The fiberoptic channel is fixed in its position, extends from the distal tip of the catheter through the catheter and connects to an eyepiece at its proximal end, which may be connected to a video camera and to a TV monitor. The fiberoptic channel is either positioned fixed within a catheter support wall which forms two centered lumens of the catheter, or is fixed in a lateral position in the side wall of the catheter in the case where the catheter has only one centered lumen. The two arcuate cutting blades, separated one from the other, can be manipulated each independently, or both simultaneously--resulting in that case in an almost completely closed pattern of a circular cut-line. The two cutting blades move in their respective separated channels of related size and shape, situated proximate to the periphery of the catheter, thus reaching in circular dimension almost the actual outer diameter (O.D.) of the catheter itself, thereby creating a minimal "dead space" between the circular cutting blades and the outer surface of the catheter, thus creating a spaced safety margin between the cutting blades and the inner surface of the vein wall. Because of this special safety margin, while negotiating forward the distal tip of the catheter, with its fixed or extendable cutting blades inadvertent damage to the vein will not occur. Each of the two arcuate cutting blade elements is angled at its tip-edge towards the center of the catheter (inwards) providing a further safety margin to prevent damaging the intimal surface of the vein when negotiating forward the catheter and its extended blade elements. The arcuate blade elements are movable forward and backwards, extendable out of the distal end of the catheter and may be pulled back into the catheter to line up with its distal end This mechanism is controlled by a two-part, two-color, split-ring control unit situated at the proximal part of the catheter and connected to the two arcuate cutting blade elements housed in their own separated channels, so that pushing either of the semi-circular elements of the control split-ring unit in the direction from the proximal part to the distal end will extend the respective arcuate cutting blade element from the distal end of the catheter. Reverse manipulation of the split-ring control unit will withdraw the blade elements into the catheter and align the edges of the arcuate cutting blade elements with the distal end of the catheter. Since the split-ring control unit is of two parts, each of the cutting blade elements can be manipulated independently or simultaneously. The arcuate, razor-sharp tip-angled cutting blade elements can be fixed at the distal-end of the catheter, extending permanently from the distal-end of the catheter for a predetermined length In that case, the arcuate cutting blade elements may be contiguous (or continuance) to form a completely closed circular shape and may be considered to be one circular, razor-sharp, tip-angled cutting blade. The method of its use involves advancing the catheter-cutter with its fixed or selectively extendable blade or blades through the blood vessel being treated, from its proximal portion towards its distal end or, conversely, if inserted through the distal part of the vessel, from its distal portion to its proximal portion, in either case excising completely and effectively any valves or other obstructions within the vein graft. A low-profile, inflatable/deflatable single segment or multi-segment balloon may be positioned at the distal tip of the catheter to serve two purposes. First, when inflated, partially it covers completely the distal tip of the catheter, thus providing a beveled soft-tipped leading edge for the catheter when being inserted into the vein, or when negotiated forward within the lumen of the vein, thus preventing accidental vein-wall damage during the insertion or manipulation process, even in a tortuous vessel configuration. This structure is referred to by me as a "balloon-tipped" catheter. In addition to the safety feature just described, when the catheter tip is precisely positioned, the catheter may be fixed in this position by fully inflating the balloon tip. The catheter can be disposable for single use, and is made from flexible materials. (i.e. polyethylene). The cutting blade elements, fixed or movable, can be made from metal. At the proximal end of the catheter is a port connector that is in connection with one of the center lumens (with the smaller one, in case of two unequal lumens) for irrigation of fluid that will be flushed through that specific central lumen out through the distal end tip of the catheter. Through the other lumen, a forceps-like biopsy device may be introduced to permit additional intraluminal manipulations. In the case in which the catheter has only one central lumen, both of the aforementioned activities may occur simultaneously through that single wide lumen. The distal part of the catheter may be constructed to permit rotation of the fixed cutting blades around the axis of the cutter at a low rotational velocity, controlled from a small hand-held battery operated drive-motor unit. This invention can best be understood by taking the description which follows in conjunction with the drawings herein, in which: FIG. 1 is a mechanical schematic diagram of valvulotome catheter, according to my invention; FIG. 1A is an enlarged view of a portion of the catheter of FIG. 1; FIGS. 2A, 2B and 2C are mechanical schematic diagrams showing alternative positioning of elements of my invention; FIG. 3 is a partially cross-sectioned view of an alternative form of my invention; FIG. 4 is a profile view of a cutting element for use in my invention; FIG. 5 is a partially cross-sectioned view of an alternative form of my invention; FIG. 6 is a partially cross-sectioned view of another embodiment of my invention; and, FIGS. 7A and 7B are partially cross-sectioned views of related portions of the device of FIG. 1. In FIG. 1 and 1A, valvulotome catheter 10 includes tube 12 having an outer diameter of from 1.5 mm. to 6.5 mm., the outer diameter being chosen to fit the blood vessel in which the instrument is to be used. Tube 12 carries a pair of arcuate, razor-sharp cutting blade elements 14, 16 in channels 18, 20 located in the walls of tube 12. This can be seen more clearly in FIGS. 7A and 7B. Blade elements 14, 16 terminate at their distal ends in razor-sharp cutting edges 22, 24, respectively. Blade elements 14, 16 are withdrawable into and extendable from channels 18, 20, respectively and independently, by way of ring-segment control elements 26, 28, respectively, which slide in slots 30, 32, respectively. Central support element 34, as shown in FIG. 1, divides the inner space of tube 12 into two symmetrically disposed lumens 36, 38 which extend through tube 12. Support element 34 supports an optional fiberoptic bundle 40 which permits viewing the operation and effectiveness of cutting surfaces 22, 24 on blade elements 14, 16, respectively. The proximal portion 42 of tube 12 includes flushing port connector 44 which communicates hydraulically with one of the lumens 36, 38 to permit flushing valve debris from the area being cut by cutting edges 22, 24. A connector 46, pneumatically coupled to an air passage 48 (FIG. 3) in the wall of tube 12, is provided for inflating a buffer balloon 50 (FIG. 3). A fiberoptic element 52 is adapted for the application of light thereto to illuminate the area where the excising of valves is occurring. The cutting scene may be observed optically or recorded for later study by way of fiberoptic element 54 and eyepiece 56. Port connector 58 has a hemostatic valve 60 associated therewith It is coupled to one of the lumens 36, 38 for the introduction of biopsy-forceps-like catheters which may be required to extract excised valves or debris in the associated blood vessel. Flushing port connector 44 is hydraulically coupled to the lumen not coupled to hemostatic valve port connector 58, for the introduction of irrigation fluid which may be necessary to flush excised valves and debris from the distal end of catheter 10 so as to assure a clear field of view when the fiberoptic channel 40 is being used. Turning to FIGS. 2A, 2B and 2C, the positioning of support element 34 of tube 12 may vary. In FIG. 2A, support element 34 is centrally disposed, thus making fiberoptic bundle 40 coaxial with tube 12 and producing two symmetrically disposed and equal-sized lumens 36, 38. In FIG. 2B, the support element 34 is displaced, the positioning of fiberoptic bundle 40 is also displaced from the center of tube 12 and two unequal lumens 60 and 62 are formed. In FIG. 2C there is a single lumen 64 and fiberoptic 40 bundle is off-axis in the wall of tube 12. In the embodiment of FIG. 2C, the same procedure of manipulating biopsy-forceps-like catheters and irrigating and flushing procedures will occur through the single lumen. In this configuration flushing port connector 46 and hemostatic port connector 58 are coupled to the common lumen 64. Turning to FIG. 3, at the distal end 70 of catheter 10 a low-profile balloon 50 is affixed. One purpose of balloon 50 is to hold fixed the position chosen by the surgeon for end 70. Another is to provide safety to the side walls of the vessel when catheter manipulation is occurring. Balloon 50 is inflated, by gas or liquid, through channel 72 which is carried in the wall of catheter 10 from the proximal port to the distal end of catheter 10. Balloon 50 may be segmented in which case multiple inflation channels must be provided, one for each segment. A multi-position control valve is provided at the proximal port of catheter 10 to selectively control whether either or both segments of balloon 50 are inflated. The selectable mode of inflation of balloon 50 permits a high degree of precision in the manipulation of catheter 10 and more accurate positioning thereof and of its cutting blades 22, 24. FIG. 4 shows the profile of one of the razor-sharp, tip-angled cutting blades in catheter 12. Of course, angled-tip blades 22, 24 are highly polished and smooth on their external angled surfaces and sharpened to a razor-like edge. In FIG. 5, angled-tip cutting blades 74 and 76 are shown fixed, longitudinally, in the distal end 78 of tube 80. Valve cutting is achieved by manipulating tube 80 from the proximal to the distal end of tube 80. Conversely, tube 80 may be moved from the distal to the proximal end of tube 12. In either mode, angle-tipped cutting blades 74, 76 sever any valves from the inner wall of the vein. A fiberoptic bundle or channel 82 may be provided coaxially within tube 80. In FIG. 6, the end portion 90 is rotatably supported from tube 12 by way of shaft 91 positioned by locating bearing 92 and support member 94. Shaft 91 terminates at its distal end in blade support member 96 which carries angled-tip, longitudinally-fixed cutting blades 98, 100. Rotation of shaft 91 at speeds of up to 50 r.p.m. by a small hand-held, battery operated drive motor at the proximal end of shaft 91 greatly enhances the cutting effectiveness of the catheter incorporating this feature. While particular embodiments have been shown and described, it will be apparent to those skilled in the art that variations and modifications may be made therein without departing from the true spirit and scope of my invention. It is the purpose of the appended claims to cover all such variations and modifications. Patent Citations
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