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Chinese Cosplay Magazine Cos Top New IssuesOk, its already passed more than 3 months after my last journal entry, so I want to post more news about cosplay magazine and YOUR photos :3Chinese Cosplay Magazine Cos Top New Issues2 years ago in Personal More Like This
I am gladly represent Chinese cosplay magazine "COSTOP", its very well-known at Southern China, have a lot of awesome photos and usefull stuff, but, sorry, Chinese only You can buy it online from taobao store, well because magazine dont have any English translation we are not sure that foreign readers will be interested on only-Chinese texts TAT But maybe we will do something about it...
So, back to the deal. Magazine want to made spotlight for non Chinese cosplayers and publish photoshoots in each issue. If you have interest in publishing your photos in magazine, you can send me photos via e-mail firstname.lastname@example.com (please, write "Cos Top Magazine" as topic of your email).
Also looking through your awesome photos, we are happy to receive interview from cosplayers, crafters, photographers, everyone who have passion to cosplay, and can tell
Need help for the background?many people have asked for help with the backgrounds.Need help for the background?2 years ago in Personal More Like This
as a request is a bit vague! it's not like the human body or an animal..
the background is .. is .. the fucking universe!
cities, mountains, seas, forests, are a combination
of elements ALWAYS different :iconexploding-headplz:
I have not received help for these things..
I learned watching pictures and drawings in the last 2 years!
you have to watch thoooousands of landscapes and store them in your
"mental-database" to be able to invent new personal backgrounds.
it works with the perspective and the composition too!
observe and learn from the experience of others.
a sort of osmosis.
if you need pictures or inspiration I recommend this site
I love it..it's absurd.. sometimes I become depressed because
is too epic.. :iconrazycryplz:
but then I react and I try to improve!:iconlazymacho2plz:
then..if you need more specific help I can try to do
some reference sheet :icony
Concurso!! ~ (+ Premios, + Entradas)40 Entradas y contando!!Concurso!! ~ (+ Premios, + Entradas)2 years ago in Personal More Like This
¡Quién falta?
La mayoría votó por una semana y dos semanas. Así que usaremos un término medio y extenderemos el plazo para el 17 de Enero , dando en total 10 días más de plazo!! [I am a dummy!]
Hay nuevas entradas!, nuevos premios!! nuevo de todo *-*
Anímense los que faltan [Love]
Más premios!! OMG! no es demasiada tentación esto?! *-*
Añadí una regla más solo para referencia. Ya sea en el meme o en la descripción del dev, por favor pónganme las fechas en las que hicieron los dibujos para poder comparar la evolución con los años *-* ¿si?
Gracias a todas las personas que decidieron unirse a la causa del antibullying aquí en DA [La la la la]. Mil gracias a todas las personas que comentaron y apoyaron esta iniciativa.
Pero en fin, a lo que vamos!
About male anatomy...It's been A TON OF TIMES that I get the same question:About male anatomy...2 years ago in Personal More Like This
"How do you draw male anatomy? Could you give me some tips?"
I will be honest: I don't know!! I can tell the way it all started though.
My sister's a doctor, and she bought Sobotta anatomy atlas, drawn by AWESOME doctors and artists. The edition she bought has got two HUGE books full of medical illustrations of bones and muscles, very detailed veins, tendoms, with sections, skinned corpses, etc. I got totally fascinated and I started to study myself but I was not good enough to draw all those things I learnt.
Then, I had one year of anatomy classes at my art studies in the University. My teacher was just BRILLIANT. He really loves human bodies and he gave us the best tips possible (and he likes manga/anime!!). We visited real life corpses so I could understand better how muscle insertions and tendoms worked. Then, the teacher asked us to draw like... 200 works in 9 months. It was CRAZY and I hated him too much. B
Commission1. Price [in US Dollars]Commission4 years ago in Personal More Like This
*** 5% will be charge later for Paypal transaction fees
Lineart Sketch[Monotone pencil drawn and shaded by pencil OR b/w pic drawn and shaded in computer] (price per character)
Your original character >>>
+++ 1 character / no bg : $17
+++ 1 character / with bg : $25
+++ 1 character / full body / no bg : $30
+++ 1 character / waist up / no bg : $20
Full CG [with full bg]
+++ waist up
1 character :$50 (in one pic / one bg)
2 characters : $70 (in one pic / one bg)
3 characters : $100 (in one pic / one bg)
4 characters : $120 (in one pic / one bg)
*** More than 4 characters, $25 will be charge for each character.
+++ Full body
1 character : $70 (in one pic / one bg)
2 characters : $100 (in one pic / one bg)
3 characters : $120 (in one pic / one bg)
4 characters : $150 (in one pic / one bg)
*** More than 4 characters, $30 will be charge for each characte
Challenge 5 - Music - TOP 5Please check out those awesome works,Challenge 5 - Music - TOP 52 years ago in Deviant Events More Like This
Sorry for taking while to give a result. It was a wonderful but hard time for me to choose top 5 since everyone seems like music theme. We have more entries than usual challenges and actually the most wonderful thing is quality of all entries are growing up. Isn't it amazing? I was so excited to see them all, therefore if you have time, please take a look at whole entries since I am sure you can find several great artists there to watch: http://hellobaby.deviantart.com/favourites/47401935
(BTW, if I miss any entries in the challenge fav folder, please tell me since sometimes I forget to add it in while I am watching them around. Thank you,)
Also look at them make me wish I could choose more, not only top 5. Yeah, it has been a really hard time to pick top 5 only (sorry, I wish I could pick more):
If you didn't make it, please don't be so upset, other challenge
Magic Knight contest - Winners!For contest's info, deadlines, and prizesMagic Knight contest - Winners!2 years ago in Personal Journal More Like This
Please kindly visit the previous journal:
Hi everyone!
Firstly, we want to say thank you to every contestants for your cooperation with us in the last 2nd round of the contest.
You all did a wonderful job, which is admirable.
However, there are only 5 top winners.
We did a lot among entries to choose the winners.
The judging factors are:
Level of details - Skills - Creativeness - Diversity between each level of the card - Enthusiasm - Efforts - and Cooperation.
Many factors right? You can see that it caused us headaches.
Luckily the voting gave us a result.
Now, not to waste your time. Let's see who the winners are.
Your prizes:
Your card will be used in our game.
500$ via Paypal
1272 DA points
In game items: 1 Premium card pack and other supplement item
CONTEST: DESIGN AN OC, WIN A TABLET (CLOSED)CONTEST CLOSED, NO MORE ENTRIES WILL BE ACCEPTEDCONTEST: DESIGN AN OC, WIN A TABLET (CLOSED)2 years ago in Personal More Like This
(If you entered and don't see your entry listed below, let me know ASAP!)
:iconyixeirt: OC Design Contest Entry: Anya by Yixeirt
:icondandandanao: The werewolf Kamal by dandandanao
:iconwaterdragontonx94: Venom contest: Villa Vesna by WaterdragonTonx94
:iconFires-storm: Maxamillion Stone by Fires-storm
:icongranoidzo: Kierra (contest entry) by granoidzoKierra close up ver. by granoidzo
:iconveritas-night: Zhizhu-jing Bio by veritas-nightZhizhu-jing by veritas-night
:iconspadiekitchenqueen: Interview with a Vouivre by spadiekitchenqueen
:iconFelixuta: Design Roswitha by FelixutaRoswitha Portrait by FelixutaRoswitha Amsel by FelixutaI hate them by Felixuta
:iconMansdefenderOakgrove: Contest own charakter Nacken by MansdefenderOakgrove
Free Painting Programs :) (updated Mar. 12)Hi there, finally! I've done all folio for institution!Free Painting Programs :) (updated Mar. 12)2 years ago in Personal More Like This
My routine and work ethics is back again ! Yeah.
I really apologize for my absent.. T_T
I will catch up everything as soon as possible.
- - - - - -
This journal I decided to make it helpful. (hopefully) ^^
If you like to paint digitally, it doesn't matter what program you are using.
As long as it is functional enough for you, and you enjoy painting when you use it. ^^
I love to try all painting programs, it's like exploring!
Though we already know that Photoshop, Painter and Sai are great, but there are free ones
that good enough to create artwork as beautiful as those programs. ^^
Many times that I randomly posted about them but this time I want to collect them all here!
So it will be convenient for you all to check and compare them.
What I can say is that I'm grateful and appreciate those creators who spent their time and hard working and share them to us.
That's why I want to support and share them to you all!
I will
Summer Update!Aahhh ok, so first off thank you all so much for the birthday wishes here! ; _ ; It was overwelhming, thank youSummer Update!3 years ago in Personal More Like This
Guh, I'm going to try to be more active online. Life's been busy busy! My god have I mentioned summer is amazing!? I'm so happy to not have to bring a big coat wherever I go. I like being able to just leave my house and walk as far as I please :"D
well ..my hair doesn't like the summer. ashdiaosjdia ffffffuuuu----
that and I don't think my body was built for anything higher then 25c degrees.
AND OMG. I FINALLY BOUGHT A 27" iMAC. *____* /caresses
First lesson I learnt using a Mac, that little rainbow wheel is the bringer of DEATH. I find it more terrifying then the PC's hour glass.
Figured I'll bust out the silly doodles out first, since realistically no one wants to hear me talk ugh, or should i say type....k I don't know how to properly say this. LOL LET ME BORE YOUR EYES.
LOL This happened one day when my brother d
January 4, 2012http://katawashoujo.blogspot.com/2011/12/katawa-shoujo-will-be-released-on.htmlJanuary 4, 20123 years ago in Personal More Like This
Oh boy oh boy oh boy
New Username Symbols: Extended ThoughtsTwo weeks ago, we released two new products – deviant and art Mentions and new username symbols. Gratefully, and as we'd hoped, many deviants are embracing these changes in exactly the ways we'd anticipated, and the ways we ourselves did over the past several months of testing. While some deviants embraced the changes, it's fair to say that others have felt surprise, curiosity, and maybe even shock. These feelings are totally normal, but for the large part, there's a hope present. A positive outlook. The first steps in a new era that makes the way for our goals in the future, and, at the same time, removes clutter and confusion that new deviants often experience.New Username Symbols: Extended Thoughts1 year ago in Personal More Like This
As with any change, there are a handful of deviants that don't understand why we made the choices we did
[ Just an update ]Thanks so much to Kageromoku for giving me a DA subscription! I was really surprised! So now I will put it to good use here.[ Just an update ]2 years ago in Personal More Like This
Supanova Sydney is coming up next month huh? I'll be cosplaying as Serah Farron (FF13-2), and Lei Fang (Dead or Alive). Hope to see you there!
Aside from that, drawing, working on doujinshi, cosplaying, classes, work has been keeping me busy! I also tend to update my tumblr with more sketches and random comics/doodles (like all the doodles below).
Anyway, I read Naruto 631 as well... and being a SasuSaku fan I couldn't help but draw this.
because.. after all this time... really.. the first thing he says is "....Sakura"Be still my shipping heart
Also have been drawing a bit of Jojo, Shingeki no Kyoujin and other random stuff like Dangan Ronpa, but my attention is still pretty much on Inazuma (heh)
Hope everyone has been doing well!
Contest END. But other ways to contribute?Update: Judging is still in process but its safe to say all the entries where of such high quality that we've struggled to narrow it down! To those waiting on results all will be posted up very soon in the meanwhile please be sure to visit the contest gallery folder and have a good look at all the amazing entries. We are super proud to run a group that has attracted so much amazing and positive energy!Contest END. But other ways to contribute?2 years ago in Personal More Like This
Contest has now ended. Thank you to everyone who has contributed! We will update the journal once the winners have been decided</b>
Don't forget you can still purchase an artbook spot here at our store envy http://etherealartbook.storenvy.com/products/1653743-artist-spot-donation if you want a secure a guaranteed artist spot in the artbook!
Raffle Results
as seen here using random.org we c
Headshot commissions wip in sta.shThought it would be better sharing the link for the wips in my sta-sh than posting unfinished works in my gallery,Headshot commissions wip in sta.sh2 years ago in Personal More Like This
this is specially for my commissioners i'm sorry for being so slow ;A; if your commission isn't there yet don't worry I'll post the last ones soon!
Go check it out:
Lance Armstrong = EPIC WINI'm frankly tired of all the little bitches in the media yapping away in their over the top outrage about Lance Armstrong's asshole behavior. It's so fashionable to hate Lance these days. Really, is this guy really supposed to be THE one we all should hate? Everyone on TV is telling you so. Well, do you?Lance Armstrong = EPIC WIN2 years ago in Personal More Like This
I just realized that I don't hate him nearly as much as all these wishy washy assholes pretending like they wouldn't do it if they had the chance. The deal? Train as hard as you can. Dope and lie about it. Win the shit. Get $100M of personal fortune, and raise a few hundred millions for charity.
Everyone condemning Lance for lying has lied numerous times, probably even that same day. The difference? He had the the balls the size of Jupiter and Saturn to take it it to its logical conclusion, and the perseverance and tenacity to win seven Tour de Frances. He's an asshole, no doubt. However, the other thousands of cyclists who doped came nowhere near accomplishing that type of feat. Keep
Stolen Art worksThank you to all of you for informing me about Hidden Supplies, it seems that they have taken one of my images along with many other fanart from different artist and was selling it online as well as at conventions.Stolen Art works2 years ago in Personal More Like This
link to their print shop
At first I was really mad and pissed, but then I learned that they apparent gotten permission from some artist to sell their works there. I can't speak for the other artist that had their works sold by them as some clam that they did g
FANPAGE ON FACEBOOK REFUSES TO CREDIT FANARTISTS!FANPAGE ON FACEBOOK REFUSES TO CREDIT FANARTISTS!!!FANPAGE ON FACEBOOK REFUSES TO CREDIT FANARTISTS!2 years ago in Personal More Like This
Well now, seriously
I follow some facebook pages.
To tell you the truth I follow the ones that credit artists for their work, because I find it nice to click on the link they provide of their galleries and almost die of happiness seeing other wonderful artworks from the same person on their own site.
But yesterday a Saint Seiya Page I follow had a funny comic stolen by a famous Anime Page on Facebook. The ADMs claim they found it on google already the way it was. Without the SSpage logo. And they put their logo on that comic, posted on their page as if it was theirs. Because seriously, when you put your logo on a work you found on internet you are automatically saying IT IS YOURS! And, of course
Daily Update DecemberDaily Update December2 years ago in Personal More Like This
SO HEY this is 11 days late but Carciphona is updating daily during December since you guys succeeded in my challenge!! I haven't been posting here because I don't want to flood manga pages, but you can go to the official website for pages daily! thank you SO much for your support once again, readers like you have me floored with what you can accomplish and I'm very grateful. ;-; please continue to vote for Carciphona here so that more people can find this webcomic! Votes are accepted daily and one second of your time, with this many of you, makes a huge difference in something that I cannot accomplish on my own. CP will only get better and I want to share it with as many people as I can.
In preorder news, all preorders have been shipped as of yesterday. I spent the past 9 days or so organi
$2.50 healthy meal for the poor or cheapIt's a well-known fact that people with lower income levels in the West generally have a poor diet. That is one of the major factors which determines their lower life expectancy, and poorer general health. The big question for me is 'why'?$2.50 healthy meal for the poor or cheap2 years ago in Personal More Like This
I am a cheapskate, and often times enjoy eating cheap food. I am also a health and fitness nut, so the food I eat must be healthy. I have a genetic predisposition to being overweight, but I have around 6% body fat due to my diet and exercise routine. For reference, my deviant ID below is probably just over 10% body fat. I am also lazy, so cooking for a long time is out of the question. Turns out that all of these conditions are easily satisfied.
Let's suppose you are poor and you have a minimum wage job. I'll give you a brief outline about how to feed yourself for ~$10 for a whole day with just about the healthiest food you can eat for ANY amount of money. That's right, you can eat better than your neighbor making over a hundred grand.
Here are just
Tuesday: Premium Member News!Welcome, Premium Members! Many of you may be here for the first time thanks to the Buy One, Get One Premium Membership sale. PremiumMembers is your home for all Premium Member news -- new features, contests and giveaways, and promotions just for Premium Members.Tuesday: Premium Member News!2 years ago in DeviantArt Announcements More Like This
And that's exactly why we're reaching out to you today. As you may have seen, Premium Members get 40% off all Prints through November 15th!
That means everything in the Prints shop is 40% off! Take home your favorite Photo Print, Fine Art Print, Wrapped Canvas, Art Gift, and more for less! Or, start your holiday shopping early and purchase a Prints product for a fellow deviant.
This sale is exclusively for Premium Members, and only for a short time! Visit the Prints Shop to take advantage of t


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Its all that you could do to make your way
Up to the threshold where we are today
And I'm the one who tries to save
Integrity but its too late.
So pull your knife out of my back.
Inventiveness is what you lack
And I won't stand for this disloyalty.
No need to read between the lines
You've screwed me one to many times
Out with the old you. You're becoming me.
The clones just took control by backbiting.
Your pride grabs hold of you and sets you free
And I'm the one you feed off of
And I can smell the avarice.
Inspection 12 Lyrics
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What chart rank did the song debut? What is the song about? Has it won any awards?, etc.
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Your introduction will appear once it has been deemed awesome by our team of wizards.
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subset: commoncrawl


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The pizza is very good but a little overpriced, but so are the other pizzerias on Grand Island. The comic book theme is cool and they have tv's at the tables.
The pizza is very good but a little overpriced, but so are the other pizzerias on Grand Island. The comic book theme is cool and they have tv's at the tables.
Love their pizza and wings! Garlic bread and salads are fantastic too. I live around the corner, but have never eaten in! Always take out.
Visited after our trip to see Niagara Falls earlier that day. 'Say Cheese' was advertised on our phonebook in the hotel room in which we stayed. Wanted to eat-in at a decent place that wasn't too far away and 'Say Cheese' was it!!! The environment was cool and warm. We loved all the comic book superhero decor. Kinda wish the... More
Visited Say Cheese Pizza co recently with my wife and daughter as my wife was jonesing for Pizza and wanted to sit and eat somewhere vs ordering pizza in or having it delivered. Being only a 20 minute drive we decided to take the trip and try something different, upon pulling up we were instantly greeted by Spiderman sitting on... More
One of our favorite pizza joints when we visit our son in Grand Island. Grand kids love the action figures and cartoon decor! A bit noisy when we eat there, but take out is available and the do deliver too.
Good pizza, good food good service. Great atmosphere. The Marvel characters keep the kids interested and the food kept me inerested.
Haven't been there since they turned the place into a hip-hop bar. Went back tonite for an Italian Sausage pizza. Don't know what that was but it wasn't good. Won't be going back.
Never had a bad meal here. Fun atmosphere. Great service. Kids love it! The food comes out fast which is good cuz we are usually starving after a little league game or other sporting event!
What a great pub,pizzeria! They have a game room. The traditional pizza is my favorite. It has a secret sprinkle on it. I am amazed at how good the stuffed banana peppers are. I am usually disapointed but still order tghem everwhere. These were spicy with sausage and cheeses. Yum! Lots of micro beer to choose from. Not the best... More
Food is consistently good. Never a bad surprise. All food of very good quality. Live music on weekends. Comfortable & entertaining.
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Movie Screening: Tough Guise 2 - Event Details
This event has concluded and is no longer current.
Movie Screening: Tough Guise 2
Location: Campus Center room 306
Upcoming on February 19th from 6-8pm in Campus Center Room 306, join us for the film screening of Tough Guise II.
In this highly anticipated update of the influential and widely acclaimed Tough Guise, pioneering anti-violence educator and cultural theorist Jackson Katz argues that the ongoing epidemic of men's violence in America is rooted in our inability as a society to move beyond outmoded ideals of manhood.
Jackson Katz is one of America's leading anti-sexist male activists. An educator, author and filmmaker, he is internationally recognized for his groundbreaking work in gender violence prevention education with men and boys. He will be presenting at UH Hilo's campus on March 5, 2014 at 5:30pm in STB, Room 108.
For a sneak peak of this movie, visit:
For more information, contact: firstname.lastname@example.com
Tags: Men of Strength Jackson Katz Tough Guise II Movie Screening Violence Awareness Ted Talk Student Health and Wellness Programs SHWP
What's also happening?
February 2014 | ||||||
Sun | Mon | Tue | Wed | Thu | Fri | Sat |
16 | 17 Holiday observed: Presidents' Day
| 18 | 19 | 20 | 21 5:45p Learn to Swing Dance
| 22 |
- International Nights Tickets on Sale
- Tickets for the annual International Nights performances are now on sale! The shows are scheduled for February 6 and 7, 2015. Tickets can be purchased at the Performing Arts Center Box Office, Tuesday-Friday from 9-1. ...
- College Goal 808
- College Goal 808 is designed to help students and their families navigate the student financial aid process. The event offers free assistance in completing the Free Application for Federal Student Aid (FAFSA) online. ...
- Pre-Valentine Concert with Kris Fuchigami
- Accomplished ʻukulele artist, Kris Fuchigami returns to 'Imiloa's Planetarium stage with special guest and award-winning artist, Brittni Paiva. Ticket includes pupus at 5:30 p.m. in Atrium, and concert at 7 p.m. under planetarium stars. ...
- PIPES 2015 Summer Internships - Online apps available!
- If you're a student looking for an exciting summer internship opportunity with agencies and organizations who work in conservation science, natural resource management, and environmental education then check out our PIPES 2015 program. ...
- UH System Common Scholarship Application 2015-2016
- The University of Hawaiʻi System Common Scholarship Application will be available online for the 2015-2016 academic year on December 1, 2014. ...
- Free Application for Financial Aid 2015-2016 and Scholarship
- To be considered for financial aid for the 2015-2016 academic year, you must complete the Free Application for Federal Student Aid (FAFSA). The website will become available on January 1, 2015. The address is www.fafsa.gov. ...
Disclaimer: The University of Hawaii at Hilo is not responsible for the contents, links and/or materials presented in any web site listed above that is not of the "hilo.hawaii.edu" or ".uhh.hawaii.edu" domains. All comments, complaints and grievances should be filed with the author, host and/or owner of said site.


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Personalized Past, Present and Future Rose Remembrance Heart
Show her that your past, present and future are forever connected with this heartwarming gift. Set in a heart-shaped box are 3 real 24K gold trimmed roses along with a plaque that can be personalized with a special sentiment. More
Most of our gifts are personalized. Please order early so you will get your gift it in time. Call for custom gift ideas.$79.95 | MORE DETAIL |
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Personalize Romantic Gifts with Your Heartfelt Message. Fast Shipping!
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Find a romantic gift for that special woman in your life!


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Dr. Rekha Mamidi, MD
Internal Medicine, Kaiser Permanente Medical Center
- 6600 Bruceville Rd
Sacramento, CA 95823 - 1 Office Location
- (916) 688-2000
Dr. Mamidi works in Sacramento, CA and specializes in Internal Medicine. Dr. Mamidi is affiliated with Kaiser Permanente and UC Davis Medical Center.
Gender: Not Available
Years in Practice: Not Available
Languages Spoken: English
Medical School: Not Available
Graduation Date: Not Available
Hospital Affiliations: Kaiser Permanente, UC Davis Medical Center
Specialties: Internal Medicine


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New Video: Young Chop x Lil Durk "Murder Team" Posted By: B.Dot November 10, 2014 @ 2:52 PM EST Videos Murder Dem.
New Music: Young Chop x Fat Trel "All I Got (Remix)" Posted By: Big Homie August 6, 2014 @ 6:15 PM EST Songs Still Got.
New Music: Fredro Santana x Lil Reese "That's A No No" Posted By: Big Homie May 23, 2014 @ 10:36 AM EST Songs No No No, Not Today.
New Music: Lil Durk x Young Thug "Party" Posted By: Big Homie May 10, 2014 @ 2:42 PM EST Songs Party Time.
New Music: Young Chop Ft. Chief Keef x Lil Reese "Bang Like Chop" Posted By: Big Homie March 30, 2014 @ 8:06 PM EST Songs Chop Chop.
New Video: 2 Chainz x French Montana "A-Rod" Posted By: Big Homie March 28, 2014 @ 3:05 PM EST Videos Ass On Steroids.


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Narrow your search
On first inspection the HP TouchSmart 300-1120 seems like a capable enough all-in-one, but it loses a lot of appeal once you compare it with others on the market. If you want an all-in-one PC for the kitchen counter, this system may work for you. For general computing or home entertainment needs, you can find several other all-in-ones with better features for the price.
CNET's reviews of the best desktop computers include photos, video, and user reviews
The HP Spectre TouchSmart XT is a rare superslim 15-inch laptop with a touch screen, but for the premium price, it should include more high-end extras.
Part touch PC, part 3D-scanning appliance: what is the Sprout? See for yourself.
A pair of pocket-sized PCs take aim at the Mac Mini and other small form factor desktops.
Beefy speakers and a bright red paint job ensure that the HP Envy 23XT Beats Special Edition all-in-one PC stands out.
Normally $329, the PC that works as both a tablet and a notebook can be had for just $199 -- but only on Thursday.
We know Microsoft is developing a number of Windows 10 versions for use on different hardware. How they will each stack up is a work in progress.
January's Windows 10 Technical Preview update adds Microsoft's virtual assistant and a few new apps.
This new virtual reality system, built around a 24-inch 3D display, might save more than a few frogs.
Google has released an iOS app that makes it possible to access your Mac or PC from any iOS device with an Internet connection.


text:
You are using an outdated browser. Please upgrade your browser to improve your ReverbNation experience.
Bred and spread out of Manhattan spiraling out...
National Touring artist since 2001
International since 2006
Not many cover or tribute bands out there ever attempt to engage in the raw talent, mysticism, and magic that is TOOL. But if you talk to four brave souls from New York City (Angelo Rivera- Vocals; Sean Murray- Bass; Donald Pusateri- Drums; Keith Williams- Guitar). Their love and passion for this music led them to form SCHISM. The world's first and longest touring tribute to TOOL! the ONLY Tool tribute endorsed on Tool's websites!
"We started this back in 2001, after seeing a TOOL show at Madison Square Garden. We simply loved the music and wanted to share it live with other TOOL minded fans" says SCHISM guitarist Keith Williams. "We've been a national touring act for over 14 years now. This isn't something you tap your foot to, this is more of an interactive experience for listener. These songs are compositional masterpieces, which will be studied for years. If you've never had the chance to see TOOL live, here's your local opportunity."
-And truly a job well done.
We invite you of the collective unconscious, to share with us, the experience of TOOL.
BOOKINGS/Artist Management: firstname.lastname@example.com
Schism Productions, LLC


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Celebrity Fashion:
People's Choice Awards
Starlets broke out what could just be the Awards season's leading red-carpet look: layers of ruffles on short little frocks.
— Jan 6, 2011
Galliano Names New Communications Director
Alexandre Malgouyres has worked at Burberry and KCD Paris.
— Jan 6, 2011
Rating the Quarterbacks
The playoff-bound QB's get judged on everything from personal style to "jerk quotient."
— Jan 6, 2011
Phillip Lim, Paris-bound... Tom Ford at Neiman Marcus in Dallas...
Phillip Lim is Paris-bound for his Fall 2011 men's show.
— Jan 6, 2011
Summer 2011 Trend: No Sweat
Contemporary designers are pumping up their new summer collections with activewear-inspired pieces.
— Jan 5, 2011
They Are Wearing:
Adelaide, Australia
Dubbed the City of Churches and boasting some of the best-preserved architecture in Australia, it's hardly a surprise that Adelaide has a passion for vintage.
— Jan 5, 2011
Marks & Spencer's Chairman Steps Down... No Barneys Return for Gene Pressman...
The departure of Sir Stuart Rose marks the end of a dramatic era at Marks & Spencer, the U.K.'s largest clothing retailer.
— Jan 4, 2011
Bryce Dallas Howard, Face of Kate Spade... Update on Ittierre/Albisetti Deal...
For the first time in the company's 18-year history, Kate Spade will feature a celebrity in its advertisements, beginning this spring.
— Jan 3, 2011
Fall 2011 Sportswear Trend:
Ice and Warm
For fall, winter sports pieces come in hot and cool tones.
— Jan 3, 2011
Fashion Rehab: December Don'ts
From bad combinations of patterns to looks that would be ideal for TV characters, the 12th month saw its share of fashion missteps.
— Jan 3, 2011
No Topshop Deal for Rihanna... Jeannie Lee and Louis Verdad Make a Dress...
Contrary to the speculation sparked by a Tweet, there is no deal in the works for Rihanna at Topshop, sources say.
— Dec 30, 2010
Celebrity Fashion: Overcoats
With winter in full swing, actresses and a designer turn to tailored toppers for respite from the cold.
— Dec 30, 2010


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The Great Gatsby
Length: 2 hours, 23 minutes
Synopsis: The film follows Fitzgerald-like, would-be writer Nick Carraway as he leaves the Midwest and comes to New York City in the spring of 1922, an era of loosening morals, glittering jazz and bootleg kings. Chasing his own American Dream, Nick lands next door to a mysterious, party-giving millionaire, Jay Gatsby, and across the bay from his cousin, Daisy, and her philandering, blue-blooded husband, Tom Buchanan. It is thus that Nick is drawn into the captivating world of the super-rich, their illusions, loves and deceits. As Nick bears witness, within and without the world he inhabits, he pens a tale of impossible love, incorruptible dreams and high-octane tragedy, and holds a mirror to our own modern times and struggles.
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Below are top resources on SparkPeople for Obsessive Exercise Disorder.
On January 1st, many of us are geared up to get healthy and fit. But, by mid-February, our diets are faltering and our fitness routines start getting stale. Falling out of a resolution can be a fast downward spiral. If you're someone who thrive... Read more
Full-fledged eating disorders are abnormal, disordered patterns of eating that become out-of-control. All types of eating disorders represent serious and immediate threats to the health, well-being, and happiness of the individuals caught up in them.... Read more
Everyone knows that athletes must plan and time their meals and snacks very carefully to reach their performance goals. But what about the rest of us? You try to squeeze in 30-60 minutes of exercise most days of the week. Do you have to be careful ab... Read more
Maybe you ate the wrong thing or, on a gotta-get-healthier kick, you ate too much of the right thing (think fiber). All you know is that the inevitable discomfort has ensued and your pants feel a little tighter than they did this morning. What exactl... Read more
When your legs ache, you can usually lie down and relax to alleviate your symptoms. But for people who suffer from Restless Legs Syndrome (RLS for short), relaxing only makes them hurt more. According to the National Institutes of Health, as many as... Read more
I need exercise tips to help lose my love handles :(... Read more
Been eating healthy and exercising since January 6th and have lost a total of 13.6 pounds!! Woohoo!... Read more
I am disabled due to a Congenital Muscular Dystrophy and Myasthenia Gravis. I am also on multiple medications and am steroid dependent (which, of course, doesn't "help" my desire to lose weight) and have other "medical issues" that complicate things... Read more
I got up early this morning to exercise. But I am confused should I exercise before or after breakfast. Thanks... Read more
Want to play exercise alphabet? Let's name an exercise (or exercises) for every letter of the alphabet! A - arm circles (to get us loosened up!)... Read more
i put fresh lime in my water..The health benefits of lime include scurvy, digestion, constipation, eye care, piles, peptic ulcer, respiratory disorders, gout, gums, weight loss, skin care, urinary disorders,... Read more
Endocrinologists treat patients who are overweight or obese, sometimes because of metabolic and hormonal problems. When someone is obese they have too much body fat. Thyroid, adrenal, ovarian, and pituitary disorders can cause obesity. Endocrinologis... Read more
Hello moms and dads! Huddle the children, your furry friends and let's get out for some exercise and away from the temptations of that beast called the fridge! See you soon!... Read more
Every parent wants what's best for their child. And for some, that means reading labels and doing as much research as they can to ensure their child's diet is a healthy one. But could too much focus on things like trans fats and high fructose corn... Read more
Whenever you decide to change your eating habits, the issue of good foods versus bad foods is likely to come up. Whether youre counting calories for weight loss and trying to figure out which foods offer the best nutrients per calorie deal, or t... Read more


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Date: 1950
Description: Interior shot of the tap room at the Blue Heron on County Truck "B" near Chippewa flowage.
Date: 1930 ca.
Description: View of Alton Van Camp wearing a hat holding a huge record Muskie listed at "59 1/2 lb" caught by his friend Louie Spray.
Date: 1920 ca.
Description: This map of Sawyer County, Wisconsin, from the early 20th century shows the township and range system, towns, sections, cities and villages, railroads, hig...
Description: Three boys each showing a bovine at the Sawyer County Fair. The boys are all wearing hats that say "Sawyer County 4-H Clubs."
Description: Exterior view of the Number 2 log cabin at Virgin Timber Lodge on Moose Lake.
Date: date unknown
Description: This map shows the township and range system, sections, dam locations, railroads, roads, selected buildings, and lakes and streams in Sawyer County, Wiscon...
Description: Winter scene with Mary and Nelson Ross of Ross' Teal Lake Lodge. They are posing in the snow with skis and snowshoes.
Description: Marker at the Uhrenholdt Memorial Forest established by farmer Soren J. Uhrenholdt on land that was part of northern Wisconsin's "Cutover Region." A leader...
Date: 1935 ca.
Description: View of a one-story log cabin, part of the Great Outdoor Club on North Lake.
Description: View over Moose Lake of log building on low hillside. A man and another person are standing on a dock next to a wood boat with a small motor attached, and...
Description: Canoes and wooden boats under a shelter at the Ojibway Museum. Other buildings, probably cottages, are visible in the background.
Description: Winter scene with children bundled-up against the cold carrying their lunch pails down a snowy rural path to the one room school house called the Pahquahah...
Description: Single-story log cabin with stone fireplace chimney on shore of Spider Lake.
Date: 1937 ca.
Description: Log cabin on cleared land near Lake Chippewa. Nearby there is an arched log bridge over a dry gully.
Date: 1932 ca.
Description: View down dirt driveway lined with stones leading up to a main building at Leibman's Resort on Lake Chippewa. Two automobiles are parked off to the far rig...
Description: Informal portrait of Mrs. Charles Belille, standing with a man and a child (possibly her husband and their child). The man wears traditional Ojibwe ceremon...
Date: 1915 ca.
Description: Front view of a public grade school.
Date: 1910
Description: Uhrenholdt family on the family farm in Seely.
Date: 1938 ca.
Description: An automobile is driving up the drive towards a two-story white wood-sided building with flower planters under the windows and a field stone chimney on the...
Date: 1919-06
Description: Ojibwe (Chippewa) Indian cemetery among brush and trees. Probably Lac Courte Oreilles.
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'Political & Politicians' Archives
Where does Udall get his money?
"So, the Koch brothers are spending millions for Cory Gardner…." So says a pro-Udall campaign ad. But look where Udall is getting his money: ActBlue and billionaire Tom Steyer. Remember back on February 19 when Udall, along with Harry Reid, Al Gore and five other Democrat senators went to Steyer's home in San Francisco to get $400,000 that night and a promise of $100 million more to come? All he asked was that they block the Keystone pipeline; and they did. According to ... Full Story
Big Oil attacking the Anti-Fracking movement
By Gary Wamsley I received a large green card in the mail yesterday. It proclaimed that "Local Control of Energy is Bad for Colorado." The card was paid for by Energy Citizens. This card immediately raised several red flags for me. First, the large size of the card means that it costs considerably more to mail than a standard postcard. That means that whoever Energy Citizens is, it is well financed, unlike most actual citizen groups I have been associated ... Full Story
Challenging the NRA
Lt. Col. Robert Bateman challenges the NRA By Demi Moaned It's been some time now since I added Charles Pierce's 'The Politics Blog' over at Esquire to my daily blogroll. His righteous indignation coupled with his madcap prose stylings are sui generis and often hilarious. But, although Pierce is the proprietor and primary contributor to the blog, other writers are sometimes featured. Among them is a semi-regular whom I've come to increasingly appreciate named Lt. Col. Robert ... Full Story
"No Labels" And Cory Gardner–Is This A Joke?
Senate candidate Cory Gardner's campaign sent out a press release on Monday claiming endorsement by the non-partisan 'No Labels' group. Foul, calls ColoradoPols.com, saying, "UPDATE: Hold everything, it looks like Gardner wasn't completely honest about this little "endorsement," press release from Gardner's campaign : "Bipartisan "No Labels" group endorses Cory Gardner." But a spokesman for the group later explained to FOX31 Denver that it is "an implied ... Full Story
More ugly campaigns thanks to Supreme Court
To the Editor Here they come again, those dark, ugly, negative, dishonest and disgusting political campaign ads that everyone professes to hate. Two recent Supreme Court decisions may make them worse. According to an article in the March 3 issue of Time Magazine, political parties are passé. Campaigns from now on will be decided principally by billionaires, dueling Super PACs, and paid mercenaries and spies. Their campaign contributions will go to candidates who support ... Full Story
Inequality in America
Inequality Nation; The American Dream Isn't Dead, But It's Dying by Progressive Populist By Brad Hennigan We've seen the stats. Wage growth for 70% of American workers has stagnated or declined over the last decade, while productivity has dramatically increased. During the same period, income growth for top earners, particularly the top 1%, has grown to the point that since the Great Recession, 95% of all new wealth generated in the U. S. has gone to 1% of its population. But ... Full Story
Christian conservatives think they're above the law
Cliven Bundy syndrome: Why Christian conservatives think they're above the law From Hobby Lobby to the Nevada rancher, members of the far right share a dangerous, anarchic pathology Amanda Marcotte, Alternet The situation with Cliven Bundy of Nevada should be a no-brainer for people from both the left and the right. Bundy has been stealing from the taxpayers for years, illegally grazing his cattle on federal lands while refusing to pay for the privilege. Both liberals and ... Full Story
Cliven Bundy Is a Pampered Millionaire, Not a Rugged
Fox News 'Hero' Cliven Bundy Is a Pampered Millionaire, Not a Rugged Rancher Watching Fox rally to the defense of moneyed interests like mining and ranching is unbearable. The latest right-wing media poster-victim, Cliven Bundy, is just the latest in a long line of desert dwellers who thinks he or she should not have to follow the law and has a god-given right to unlimited use of public resources, in this case, rangeland. I know the mentality well, because I grew up in rural Nevada ... Full Story
Tea Party has become a terrorist group
It's Time to be Honest: The Tea Party Has Become a Terrorist Group April 16, 2014 By Allen Clifton While I'm sure many liberals who come across this headline will have some response like "Duh" or "Tell me something I didn't already know, " I think it's time to put hyperbole aside and get real for a moment. Sure, for a while many liberals have called tea party supporters domestic terrorists and have accused them of actively trying to sabotage our ... Full Story
Democracy, sold down the river
America the voiceless: Voters can't compete with big campaign cash American public has 'virtually no influence' over politics in face of wealthy interest groups, study finds April 16, 2014 11:30PM ET by Wilson Dizard @willdizard It's not just your imagination: The influence of money in politics has indeed drowned out the voices of American voters, a new analysis shows, with runaway corporate lobbying and a lack of campaign finance reform to blame for giving ... Full Story


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An unscheduled view of Mr. Michael Jackson's Wild Rite when it's bathed in children
Mr. Michael Jackson is genetically predisposed to be the worst pedestrian in the wilderness. On this attraction, you pretend that you are her, smashing into Michael Jackson Hall, speeding through the state, avoiding the police, and even making a Dionysian journey into Denmark!
Run from Princess Mode
© copyright 2011–2015
A Pants Aflame production


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Ohio Primary May 6 Tuesday: Boehner Below 50% – Get Out The Vote For J.D. Winteregg by Maggie • May 4, 2014 Ohio's 8th District, you have the opportunity to change the complexion of the U.S. House of Representatives from orange to a brighter shade of red, white and blue. Want another vote against amnesty? Vote for J. D. Winteregg in the… Read more →
Fast Tracking Non-English Speakers to Disability, Because They are Non-English Speakers by Maggie • May 4, 2014 You probably think having a disability means something like having a bad back or neck, a crippling disease, a catastrophic disease, or a mental illness, but no, a "little known" Social Security "loophole" can put a non-English speaker on a… Read more →
Believers in Nice Jesus Ignorant of Scripture? National Council of Churches, Listen-Up! by Maggie • May 4, 2014 I just watched Pastor Mark Brazee of Tulsa's World OutReach church speak from the Jordan River. I haven't attended World OutReach. I know nothing about the church's affiliations other than what I see online. I do know the church is… Read more →
Republican Mark Callahan Oregon US Senate Candidate Demands Respect From Nigel Jaquiss: Callahan Dem, Green Party Candidate in Past by Maggie • May 4, 2014 Republican Mark Callahan is a candidate for the U.S. Senate from Oregon. He took exception to "Pulitzer Prize" winner Nigel Jaquiss writing "blah blah blah blah blah" on a notepad as candidate Joe Rae Perkins was doing a phone interview. "Willamette… Read more →
Clayton Lockett: Oklahoma Deeply Troubles Barack Obama – Barack Obama Deeply Troubles Oklahoma by Maggie • May 3, 2014 Barack Obama, never missing an opportunity to defame the United States, went to a German reporter to say that judges in America are biased against blacks — Oklahoma troubles him deeply, he said, expressing sympathy for Clayton Lockett, the black piece… Read more →
Benghazi: Op Zero Footprint – US & Allies Freak Over Gaddafi Demand for Gold for Oil – End Is Near by Maggie • May 3, 2014 In March 2011, Reuters announced a secret order signed by Barack Obama to provide covert support for Libyan rebel forces. The operation became known as Zero Footprint, but after Obama finished with it, Big Foot was identified. For about 18… Read more →
Benghazi: Strange String of Command – Buck McKeon Refutes Lovell's "Insights" – Someone Has Something to Lose by Maggie • May 2, 2014 What does the House Armed Services Committee have to gain or lose by believing (or not) the men in command on the night of September 11, 2012? There is no willingness in Congress to believe the word of those in… Read more →
Watchers of Weasels Winners Announced Today – Guv'mint Surveillance Edition by Maggie • May 2, 2014 The Watcher's of Weasels Council gave my Common Core article an Honorable Mention this week. Rebecca Steinitz is a an educator. She supports Common Core yet was appalled at the high school tests she, herself, took. Many thanks to these… Read more →
Ben Rhodes Email Recipients: Most Lead to White House – Even Michelle Obama's Letter Opener Was Schooled by Maggie • May 1, 2014 Once again it is Judicial Watch we have to thank for revealing Benghazi information hidden from the public and even Congress. Even Michelle Obama's "letter opener" was on the Susan Rice Prep email list. Ben Rhodes, Obama's "Strategic Communications Director"… Read more →
Benghazi 9/11/12 @ 6:17 pm Susan Rice Given Tweet From Freelancer @JomanaCNN in Libya: Ansar al-Sharia Attacking Benghazi Compound by Maggie • April 30, 2014 I'm wading my way through the new documents on Benghazi released by Judicial Watch and found an shocking tweet by CNN freelancer Jomana Karadsheh. The tweet was forwarded to Ambassador Susan Rice on September 11, 2012 at 6:17 p.m. U.S.… Read more →
Bennie Thompson on Nation of Islam Radio: Ideas From Black Men – Whites Are Always Against Them by Maggie • April 30, 2014 Congressman Bennie Thompson (D-MS), speaking on Louis Farrakhan's Nation of Islam radio told listeners that ideas from black men are rejected "just because a black man created it." Thompson is the thug that sent a letter to uniform maker, Cintas,… Read more →
Bundy Ranch: BLM Has Authority to Auction Public Lands – Harry Reid Has Power To Be First In Line by Maggie • April 29, 2014 Speculations about the reasons for the BLM raid on Cliven Bundy's ranch and property has gone in about every direction but one. Tortoises, solar plants, mining and disdain for an old rancher who was the last man standing after his… Read more →
J.D. Winteregg, John Boehner Challenger Has BEST Secure Border First Immigration Plan by Maggie • April 29, 2014 I participated in a blogger conference call last night with J.D. Winteregg, candidate for Ohio's U.S. House seat currently occupied by Speaker John Boehner, in the state's 8th District. J.D. has developed a unique plan to secure the border first,… Read more →
LaVoy Finicum: Cliven Bundys Neighbor on Points of Law of Grazing Rights – Speaks Directly to Glenn Beck by Maggie • April 29, 2014 LaVoy Finicum is Cliven Bundy's neighboring rancher on the Arizona side. Mr. Finicum posted an incisive video to explain what happened on the day the Bundy cattle were rescued, and particularly to answer Glenn Beck's "misrepresentation" of the story. Finicum rode… Read more →
Steve Stockman Points to Law in Bundy Case: Law May Not Be Helpful by Maggie • April 28, 2014 After Harry Reid issued a public threat to the Cliven Bundy family: "It's not over," "Congressman Steve Stockman (R-TX) went to public law to determine what authority the BLM has, to do what they did to Bundy, and sent a… Read more →
Prof Robert Stavins: Climate Change Meeting: 2 Scientists Surrounded by 45-50 Gov Officials by Maggie • April 28, 2014 Harvard Professor Robert Stavins, one of two lead authors of the latest report from the climate change thugs in the United Nation's IPCC, released an online letter yesterday, letting the truth fly. John Hayward writing at Human Events says the… Read more →
Reid: Obama No Negro Dialect – Bill Clinton: Would Be Getting Us Coffee – Cliven Bundy: Cattle Dung Protein for Tortoises by Maggie • April 28, 2014 Dr. Martin Luther King, Jr. used the word "Negro" more than once in his I Had a Dream Speech. Had he lived, MLK would be about 89 years old today. I wonder if he would have embraced the word "black,"… Read more →
Quapaw Ok 2 Dead from Fast Forming Tornado: My Internet, Email Service Off and On by Maggie • April 27, 2014 Northeastern Oklahoma is in a stormy state of mind this evening. It has been windy today (not that that's unusual) and my Internet provider, Cox, has been down most of the afternoon — unusual for them. Right now in Tulsa,… Read more →
Univ of Hawaii Hilo Students Told to Stand in "Free Speech Zone" To Hand Out Copies of Constitution by Maggie • April 27, 2014 During an outdoor student-on-campus event, the University of Hawaii forced, or tried to force, students Anthony Vizzone and Merritt Burch, to stand in an area referred to as a "free speech zone" while handing out free copies of the U.S. Constitution. The University of… Read more →
Sarah Palin: Baptize Terrorists by Waterboarding – Gun Free Zones "Stupid on Steroids" by Maggie • April 27, 2014 Sarah Palin spoke at the National Rifle Association's (NRA) Stand and Fight Rally in the Indiana Convention Center in Indianapolis saying "if I were in charge they would know that waterboarding is how we baptize terrorists," the idea of gun-free zones… Read more →
Amnesty-Bound Eric Cantor Won't Debate Dave Brat – Cantor Can't Face Voters in Virginia's 7th District? by Maggie • April 26, 2014 The powers behind the Republican Party of Virginia (RPV) remind me of the DOJ putting Obama's major donor Barbara Bosserman in charge of investigating the IRS targeting of conservatives. In-your-face arrogance. The conflict of interest in hiring Shaun Kenney as… Read more →
Oklahoma Rejected Eric Holder: Judge Vicki Miles-LaGrange Addresses OKC Policy Academy Swearing In by Maggie • April 25, 2014 Eric Holder's 'people' cancelled his speech at the Oklahoma City Police Academy graduation class with little notice — in fact, close to no notice. The earliest reports I find are dated April 24th, the day of the swearing-in ceremony for Police… Read more →
Rebecca Steinitz, Educator, Writes to Obama About Daughter's Common Core Testing by Maggie • April 25, 2014 Rebecca Steinitz, a parent with impressive credentials in education (Ph.D. in English) and a supporter of Common Core, wrote an open letter to the Obama's comparing what her daughter and excellent student, Eva, found about Common Core testing, that Obama's… Read more →
Palestine: US Gives $313M for Home Mortgages, $110M More for Loan Guarantees: US Home Buyers Left Out by Maggie • April 23, 2014 U.S. tax payers sent $313 million tax dollars to Palestine to "fund" mortgages for Arabs, and another $110 million in loans to small and medium-sized businesses on the West Bank. The Fed has been printing $85B every month for a… Read more →
Ted Nugent: I Like Dead Repeat Offenders by Maggie • April 23, 2014 Ted Nugent interviewed with Evan Smith of Texas Monthly. I'm not sure of the date of this video. It was uploaded to YouTube in May 2013. While Nugent talks about the Second Amendment, his remarks about "repeat offenders" should be… Read more →
Willie Myrick Escapes Kidnapper By Singing Every Praise Over & Over: Do You Know This Man? by Maggie • April 22, 2014 Ten year old Willie Myrick was kidnapped from his front yard in Atlanta. For three hours the predator drove around with Willie in the car, while Willie sang Hezekiah Walker's gospel song, Every Praise – for three hours straight, until the man… Read more →
NY State's Absurd Statement About "Authenticity" and Common Core, Testing with Barbie & Obamas African Village Project Resurrected? by Maggie • April 22, 2014 "Afro-centric" is the word being used for a Common Core curriculum for K-10th that has been a closely guarded secret until now, and still secret is where will the Afro-centric studies be taught, other than Chicago Public schools? At least… Read more →
Eric Holder Speaking at Oklahoma City Police Academy Graduation: Protest Rally Details by Maggie • April 21, 2014 Bill Citty is the Oklahoma City Chief of Police. His phone number is 405-297-1100. Reach Mayor Mick Cornett at 405-297-2424. Federal Judge Vicki Miles-LeGrange was reportedly slated to speak, had to cancel and recommended Attorney General Holder OR the invitation… Read more →
George Washington's Personal Recipe Rye Whiskey From Mt. Vernon: New Batch Coming to Market by Maggie • April 21, 2014 A year ago at my wine blog, Maggie's Wine, and here at Maggie's Notebook, I posted on President George Washington's distillery, located a few miles down the road from his Mt. Vernon home. At the time, near the end of… Read more →
Eric Cantor Political Consultant Shaun Kenney Appointed Exec Dir of Republican Party Virginia – Fair Election? by Maggie • April 21, 2014 Congressman Eric Cantor (R-VA), majority whip for the U.S. House of Representatives, has quite a game going in his home state of Virginia, maybe a game ending in political life or death. Cantor, a left-leaning Republican, teetering on the right… Read more →
Resurrection Day: He is Risen! Lift The Song, Cast Away All Sadness, We Must Leave the Sighing by Maggie • April 19, 2014 Lo, the Marys in the gloom Weeping, bowed with sorrow, Little dreaming at the Tomb What their joy tomorrow Romans 8:38, 39 For I am persuaded, that neither death, nor life, nor angels, nor principalities, nor powers, nor things present,… Read more →
Summit on Transfer of Public Lands Back to States – Been Done Before, Numerous Times by Maggie • April 19, 2014 On Friday February 18, 2014, nine states met in Utah's State Capitol to decide how to take their state's public lands back from the Feds. Utah House Speaker Becky Lockhart said at one time, 90 percent of Illinois lands were… Read more →
Bob Goodlatte: "Entirely Possible" To Pass Immigration Reform in 2014 by Maggie • April 18, 2014 Boehner is waiting for Obama to prove "himself a trustworthy partner to Republicans." That would be when hell freezes over, right? Boehner said in December 2013, "The American people are in charge of this country and they deserve a Congress that… Read more →
Louie Gohmert Amnesty: Leadership Hell Bent on It – Boehner Hired Amnesty Advocate to Work On It by Maggie • April 18, 2014 Continuing with Part 3 of my conference call on April 15, 2014 with Congressman Louie Gohmert and other bloggers and media representatives, my question for the Congressman was about immigration. If you are still living in the world of reason,… Read more →
Eric Holder: Impact of Contempt of Congress? No Respect for Those Voting – Not a "Huge Impact on Me" by Maggie • April 18, 2014 You know the story of Attorney General Eric Holder telling Congressman Louie Gohmert "Don't go there buddy…." in a recent House hearing, but as with everything and everyone in the Obama administration, there's more to the story — a twist.… Read more →
Resurrection Day – The Timeline: Rising on the Third Day by Maggie • April 17, 2014 The three days leading to the Resurrection are difficult to comprehend. If Christ was crucified and buried on Friday, but rose on Sunday, He did not spend three days in his grave, as the Bible tells us He did, and… Read more →
Al Sharpton Easter Message: Jesus Humiliated, Mocked Crucified, Rose – Barack Obama too. by Maggie • April 17, 2014 Al Sharpton explained "the message" of Easter for us, which is: Barack Obama "took" some kind of awful-something from us, yet has "politically" risen again," and so can you. The man is an ordained Baptist minister, but I haven't blamed… Read more →
Louie Gohmert: IRS Targeting & Justice – Holder, In Contempt, Strolling Down Aisle at SOTU by Maggie • April 17, 2014 This continues Part 2 of the conference call I participated in with Congressman Louie Gohmert (R-TX) on the evening of Tax Day, in the year of our Lord 2014. This ardent, dedicated congressman more or less laid bare the bottom-line… Read more →
John Boehners Electile Dysfunction: How to DeFund Planned Parenthood by Maggie • April 16, 2014 Listen-up. If you have a Boehner lasting longer than 23 years, don't give up, there's a fix for you. More below the video. I dare you not to guffaw. J.D. Winteregg for Congress: When The Moment is Right (video)Republican J.… Read more →
Louie Gohmert: House Leadership Working With Soros to "Take-Out" Tea Party, Conservatives – Destroying Our Base by Maggie • April 16, 2014 I participated in a conference call last night (April 15, 2014) with Congressman Louie Gohmert (R-TX). Focus topics were Attorney General Eric Holder, the Bureau of Land Management (BLM), amnesty and House leadership raising money to "take-out" the Tea Party.… Read more →


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Kidney disease relapse bothers patients normal life. After research, the common cause for this problem is that the patients fail to find a systemic treatment. Read on and find the new therapy--immunotherapy for kidney disease.
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Publications (196)734.25 Total impact
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ABSTRACT: Cholangiocarcinoma (CCA) is a difficult cancer to diagnose in the early stage and to treat by curative resection. The incidence of CCA in the northeast of Thailand is the highest in the world. To make progress in detecting a high risk group and in the prevention and detection of CCA, we have been analyzing the risk factors for CCA. Although liver fluke infection is known to be a risk factor, there are patients who are not infected with the liver fluke and not all people infected with the liver fluke will suffer from the disease. Therefore, it is of the utmost importance to analyze the risk factors and the mechanism to prevent the disease and also to detect the disease in its early stage to save patients' lives. Through collaboration among Thai and Japanese researchers, we analyzed the genetic and environmental determinants of risks for CCA. Also, we have been trying to develop methods to detect the disease in a non-invasive way. Without repeating findings reported in various reviews on CCA, we will first discuss the environmental and genetic determinants of the risks for CCA. Second, we will discuss the properties of CCA, including the etiological agents and the mechanism of cholangiocarcinogenesis, and finally, we will discuss future approaches to prevent and cure CCA from the standpoint of evidence-based medicine. We will discuss these points by including the data from our laboratories. We would like to emphasize the importance of the genetic data, especially whole genome approaches, to understand the properties of CCA, to find a high risk population for CCA and to develop effective preventative methods to stop the carcinogenic steps toward CCA in the near future. In addition, it is of the upmost importance to develop a non-invasive, specific and sensitive method to detect CCA in its early stage for the application of modern medical approaches to help patients with CCA.World journal of gastrointestinal pathophysiology. 11/2014; 5(4):570-8. - [Show abstract] [Hide abstract]
ABSTRACT: Cholangiocarcinoma is one of the most serious diseases in northeast Thailand, where its incidence is reported to be the highest in the world. We tried to develop a new method to detect cholangiocarcinoma in the early stages using serum proteins. We found that after fluorescent labeling of the sugar moiety of serum proteins, a new peak was identified, which might be a promising marker for cholangiocarcinoma.Journal of hepato-biliary-pancreatic sciences. 01/2014; - [Show abstract] [Hide abstract]
ABSTRACT: Although Opisthorchis viverrini is a risk factor for cholangiocarcinoma, not all the infected individuals develop cholangiocarcinoma. We investigated whether the base excision repair enzyme gene polymorphisms with differentiated repair capacities of inflammation-related deoxyribonucleic acid damage may play a key role and such possible effects from those genes may be increased or diminished in co-existence of polymorphisms of metabolic enzymes, including glutathione-S-transferases mu 1 and glutathione-S-transferases θ1. We genotyped five non-synonymous single-nucleotide polymorphisms of three genes, including the human homolog of the 8-oxoguanine glycosylase 1 Ser326Cys, X-ray repair cross-complementing protein 1 Arg194Trp, Arg280His and Arg399Gln and poly (adenosine diphosphate ribose) polymerase 1 Val762Ala in 87-94 matched case-control pairs, and examined relations between those polymorphisms and the risk of cholangiocarcinoma. Any single polymorphism did not have a measurable association with the risk of cholangiocarcinoma. However, when considering glutathione-S-transferases mu 1 polymorphism together, the human homolog of the 8-oxoguanine glycosylase 1 codon 326 polymorphism was related to the decreased risk; odds ratios were 1.00 (reference), 0.06 (95% confidence interval 0.01-0.53), 0.06 (0.01-0.54) and 0.14 (0.02-1.08) for persons with human homolog of the 8-oxoguanine glycosylase 1 Ser/Ser and glutathione-S-transferases mu 1 wild, ones with Ser/Ser and glutathione-S-transferases mu 1 null, ones with Ser/Cys or Cys/Cys and glutathione-S-transferases mu 1 wild and ones with Ser/Cys or Cys/Cys and glutathione-S-transferases mu 1 null, respectively (P for interaction <0.01). Further adjustment for the presence of anti-Opisthorchis viverrini antibody, smoking and alcohol drinking did not change the decreased risk. Other combinations of deoxyribonucleic acid-repair gene polymorphism and glutathione-S-transferases were not associated with the risk of cholangiocarcinoma. The present findings suggested that decreased capacity of deoxyribonucleic acid-repair gene, human homolog of the 8-oxoguanine glycosylase 1, may be related to decreased risk if much damaged cells die before malignant transformation.Japanese Journal of Clinical Oncology 09/2013; · 1.75 Impact Factor -
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ABSTRACT: Cholangiocarcinoma (CCA) associated with Opisthorchis viverrini (Ov) chronic infection is the most frequent primary liver cancer in Thailand, and current approaches to early diagnosis and curative treatments are largely disappointing. We hypothesize a role for protein kinase A (PKA) in Ov-induced CCA. First, we studied the PKA isozyme switching in the liver from the hamster CCA model using quantitative (q) PCR, in situ hybridization, and immunohistochemical and western blot analysis. Second, the presence of extracellular PKA (ECPKA) in CCA cell lines and their conditioned media was demonstrated by western blot and PKA activity assay. Third, we determined the association between PRKAR1A expression and serum ECPKA autoantibody in patients with CCA by ELISA. We demonstrated that an increased PRKAR1A expression is restricted to the biliary cells starting from week 1, with remarkable up-regulation when CCA has completely developed by week 24. The switching of the PKA regulatory subunit isoforms from PRKAR2B/PKAII to PRKAR1A/PKAI is significantly associated with cholangiocyte proliferation. Further, we observed that human CCA cell lines express PRKAR1A but not PRKAR2B and excrete ECPKA. Finally, ECPKA autoantibodies are detected in serum of patients with CCA, adenocarcinoma, and Ov infection with periductal fibrosis, but not from Ov-infected subjects without periductal fibrosis lesion and healthy controls. We conclude that PKA isozyme switching and the PRKAR1A/PKAI pathway might contribute to the induction of cholangiocyte transformation and proliferation in Ov-induced CCA. Overexpression of PRKAR1A leads to secretion of ECPKA which is associated with serum autoantibody that may constitute a biomarker for human CCA genesis.Tumor Biology 08/2012; · 2.84 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: The cell of origin of tumors and the factors determining the cell of origin remain unclear. In this study, a mouse model of precursor B acute lymphoblastic leukemia/lymphoma (pre-B ALL/LBL) was established by retroviral transduction of Myc genes (N-Myc or c-Myc) into mouse bone marrow cells. Hematopoietic stem cells (HSCs) exhibited the highest susceptibility to N-Myc-induced pre-B ALL/LBL versus lymphoid progenitors, myeloid progenitors and committed progenitor B cells. N-Myc was able to induce pre-B ALL/LBL directly from progenitor B cells in the absence of Ink4a and Arf. Arf was expressed higher in progenitor B cells than Ink4a. In addition, N-Myc induced pre-B ALL/LBL from Arf(-/-) progenitor B cells suggesting that Arf has a predominant role in determining the cell of origin of pre-B ALL/LBL. Tumor cells derived from Ink4a/Arf(-/-) progenitor B cells exhibited a higher rate of proliferation and were more chemoresistant than those derived from wild-type HSCs. Furthermore, the Mdm2 inhibitor Nutlin-3 restored p53 and induced massive apoptosis in mouse pre-B ALL/LBL cells derived from Ink4a/Arf(-/-) cells and human B-ALL cell lines lacking Ink4a and Arf expression, suggesting that Mdm2 inhibition may be a novel therapeutic approach to the treatment of Ink4a/Arf(-/-) B-ALL/LBL, such as is frequently found in Ph(+) ALL and relapsed ALL. Collectively, these findings indicate that Ink4a and Arf are critical determining factors of the cell of origin and the therapeutic sensitivity of Myc-induced lymphoid tumors.Oncogene 06/2012; 31(23):2849-61. · 8.56 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: P5, one of the protein disulphide isomerase (PDI) family members, catalyses disulphide bond formation in proteins and exhibits molecular chaperone and calcium binding activities in vitro, whereas its physiological significance remains controversial. Recently, we have reported that P5 localizes not only in the ER but also in mitochondria, although it remains unclear so far about its physiological significance(s) of its dual localization. Here we report that H(2)O(2)- or rotenone-induced cell death is suppressed in MTS-P5 cells, which stably express P5 in mitochondria. H(2)O(2)-induced cell death in Saos-2 cells occurred, in large part, through caspase-independent and poly(ADP-ribose) polymerase (PARP)-dependent manner. In MTS-P5 cells challenged with H(2)O(2) treatment, PARP was still activated, whereas release of cytochrome c or apoptosis-inducing factor and intramitochondrial superoxide generation were suppressed. We also found that mitochondrial P5 was in close contact with citrate synthase and maintained large parts of its activity under H(2)O(2) exposure. These results suggest that mitochondrial P5 may upregulate tricarboxylic acid cycle and possibly, other intramitochondrial metabolism.Journal of Biochemistry 04/2012; 152(1):73-85. · 3.07 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Centrosome amplification (also known as centrosome overduplication) is common in cancer cells and can be induced by DNA damaging agents. However, the mechanism and significance of centrosome amplification during carcinogenesis or after DNA damage are not clear. Previously, we showed that centrosome amplification could be induced by 3-aminobenzamide (3-AB), an inhibitor of poly(ADP-ribose) polymerases (PARPs) in mouse embryonic fibroblasts. In this paper, we determined if the effect of 3-AB on centrosome amplification was dependent on DNA damage in CHO-K1 cells. We used the well-known mutagen/carcinogen N-methyl-N'-nitro-N-nitrosoguanidine (MNNG). Ten micromolar MNNG and 10 mM 3-AB induced significant centrosome amplification in 18.1 ± 1.1% and 19.4 ± 1.8% of CHO-K1 cells, respectively, compared to 7.0 ± 0.5% of untreated CHO-K1 cells. AG14361, another potent inhibitor of PARPs, also induced centrosome amplification. We then used γ-H2AX analysis and alkaline comet assays to show that 10 μM MNNG induced a significant number of DNA lesions and cell cycle arrest at the G(2) /M phase. However, 10 mM 3-AB neither induced DNA lesions nor altered cell cycle progression. In the umu test, 10 μM MNNG was mutagenic, but 10 mM 3-AB was not. In addition, 10 μM MNNG induced significant accumulation of ataxia telangiectasia mutated protein in the nuclei, but 10 mM 3-AB did not. Thus, we found no association between apparent DNA lesions and centrosome amplification after 3-AB treatment. Therefore, we propose the presence of a novel pathway for centrosome amplification that does not necessarily require DNA lesions but involves regulation of epigenetic changes or post-translational modifications including polyADP-ribosylation.Cancer Science 11/2011; 103(2):191-6. · 3.53 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Oxysterols are oxygenated derivatives of cholesterol generated by enzymatic reactions mediated by cytochrome P450 family enzymes or by inflammation-associated non-enzymatic reactions. Oxysterol binding proteins (OSBPs) are cytosolic high affinity receptors for oxysterols. We previously found that OSBPL-8 is upregulated in liver fluke (Opisthorchis viverrini)-induced hamster cholangiocarcinoma (CCA). Our aims were to determine the expression patterns of OSBP isoforms in human CCA tissues and to evaluate whether OSBPs could be used as molecular markers for the identification of blood-borne CCA metastasis. Expression levels of OSBP1, OSBP2, OSBPL-7 and OSBPL-8 in CCA tissues were detected using qRT-PCR and immunohistochemistry. Expression of OSBPs at mRNA level in the blood of CCA patients was also investigated. We confirmed increased expression of OSBPL-8 in O. viverrini -induced hamster CCA tissues. Moreover, increased expression of OSBP1, OSBP2, OSBPL-7 and OSBPL-8 was seen in human CCA tissues. Notably, a significant increased level of OSBPL-7 mRNA was observed in tumor compared to non-tumor liver tissue. Immunohistochemistry supported the mRNA results, in that OSBPL-7 protein was over-expressed in cancer cells and hepatocytes but not in normal biliary cells and surrounding inflammatory cells. Interestingly, in our preliminary results, significantly higher levels of OSBP2 and OSBPL-7 mRNA were seen in blood samples from CCA patients than in healthy controls. These results suggest that OSBP2 and OSBPL-7 might serve as molecular markers for the identification of CCA metastasis in the bloodstream.Parasitology International 07/2011; 61(1):136-9. · 2.11 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Myristoylated alanine rich C kinase substrate (MARCKS) has been implicated in PKC-mediated membrane-cytoskeleton alterations that underlie lipopolysaccharide (LPS)-induced macrophage responses. MARCKS is postulated to be involved in inflammation-associated CCA based on its overexpression in cholangiocarcinoma (CCA) and inflammatory cells. The aims of this study were to investigate localization patterns of MARCKS in hamster and human tissue during cholangiocarcinogenesis and to examine the involvement of MARCKS in inflammation. MARCKS protein expression was found prominently in inflammatory cells of Opisthorchis viverrini-treated as well as O. viverrini plus N-nitrosodimethylamine (NDMA)-treated hamsters from week 2 to week 3 of treatment. The positive signal decreased during week 4 to week 12, then increased again at week 26 when CCA developed. At the last time point the expression of MARCKS was observed in both cancer and inflammatory cells. MARCKS protein expression was also found in inflammatory cells, including macrophages in human CCA tissues. O. viverrini excretory/secretory products or worm antigen induced MARCKS mRNA and protein expression in a dose- and time-dependent manner in the human U937 macrophage cell line. The relative mRNA expression of MARCKS in white blood cells of O. viverrini-infected patients was significantly higher than in healthy subjects (P = 0.02). Thus, MARCKS is significantly expressed in macrophages and plays a role in inflammation-related CCA induced by O. viverrini.Parasitology International 07/2011; 61(1):140-4. · 2.11 Impact Factor -
Article: PRKAR1A is overexpressed and represents a possible therapeutic target in human cholangiocarcinoma.
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ABSTRACT: The protein kinase A regulatory subunit 1 alpha (PRKAR1A/PKAI) pathway is overexpressed in varieties of tumors and cancer cell lines including cholangiocarcinoma (CCA), although its role in CCA growth modulation is unclear. In our study, we evaluated the effect of PRKAR1A/PKAI targeting on CCA cell proliferation. Real-time PCR demonstrated an increased mRNA expression of PRKAR1A/PKAI, whereas protein kinase A regulatory subunit 2 beta (PRKAR2B/PKAII) was downregulated in human CCA tissues and CCA cell lines. Immunohistochemistry of human CCA tissues revealed increased PRKAR1A with decreased PRKAR2B protein expression. Moreover, CCA cell lines showed abundantly expressed PRKAR1A, while lacking PRKAR2B expression. Silencing PRKAR1A expression induced growth inhibition and apoptosis of CCA cells, with an associated decrease in mitogen-activated protein kinases, PI3K/Akt, JAK/STAT and Wnt/β-catenin pathway signaling. The inhibition of PKA using a PKA inhibitor and cAMP analogs also led to a significant cell growth inhibition. In conclusion, our study reports the overexpression as well as molecular mechanisms by which PRKAR1A/PKA regulates human CCA cell growth. Importantly, abrogation of gene expression caused significant CCA cell growth inhibition, oncogenic signaling and coupled apoptosis induction, suggesting PRKAR1A's potential as a drug target for CCA therapy.International Journal of Cancer 07/2011; 129(1):34-44. · 6.20 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: PolyADP-ribosylation plays an essential function in maintenance of genomic stability and cell survival. Although there are several proteins served as acceptor proteins in vitro, there are few proteins in vivo that are identified, including poly(ADP-ribose) polymerase-1. We have been studying to analyze the mechanism of neuronal cell death observed in poly(ADP-ribose) glycohydrolase (PARG)-knockout Drosophila melanogaster that shows accumulation of polyADP-ribosylated proteins in the brain. As the first step, we have been trying to isolate the polyADP-ribosylated accepter proteins from the PARG-knockout fly. The strategy is to extract the polyADP-ribosylated proteins and isolate them with affinity chromatography using monoclonal antibody against poly(ADP-ribose) (PAR) (10H). The bound fraction was eluted by buffer containing salt. Next, part of eluted fraction is treated with NaOH for separating the proteins from PAR chain. Nontreated fraction and treated fraction were separated with two-dimensional gel electrophoresis. After protein staining, the specific spots that were newly found after NaOH treatment were candidate acceptor proteins for polyADP-ribosylation in vivo and could be analyzed with liquid chromatography-mass spectrometry. We present the procedure to this approach.Methods in molecular biology (Clifton, N.J.) 01/2011; 780:377-90. · 1.29 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Human T-cell leukemia virus type-1 (HTLV-1) causes adult T-cell leukemia and HTLV-1-associated myelo-pathy/tropical spastic paraparesis. HTLV-1 is mainly transmitted through blood transfusion and breastfeeding, but viral proliferation in the body in vivo shortly after transmission is not well understood. To investigate whether the route of infection influences the early stages of viral proliferation, we inoculated BALB/c mice with MT-2 cells, an HTLV-1-producing human T-cell line, via different routes, and evaluated the proviral load and humoral immune responses. One month after infection, the provirus was detected in most organs of the mice infected intraperitoneally, and substantial proviral loads were detected in the peripheral blood and secondary lymphoid organs. In contrast, the mice infected intravenously and orally showed low proviral loads, and the provirus distribution was limited to the spinal cord among the intravenously inoculated mice and to the liver among the perorally inoculated mice. Mice infected intraperitoneally also exhibited higher interleukin-2 production than the mice infected intravenously or orally, or than the uninfected control mice, while anti-HTLV-1 antibody titers were comparable between the mice infected intraperitoneally and intravenously. These results demonstrate that the route of primary HTLV-1 infection influences the establishment of HTLV-1-infected cell proliferation and the cell reservoir in mice.Experimental and therapeutic medicine 01/2011; 2(1):89-93. · 0.94 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Myristoylated alanine-rich C kinase substrate (MARCKS), a sub-strate of protein kinase C (PKC) has been suggested to be impli-cated in cell adhesion, secretion, and motility through the regulation of the actin cytoskeletal structure. The quantitative real-time–polymerase chain reaction analysis revealed that MARCKS is significantly overexpressed in Opisthorchis viverrini-associated cholangiocarcinoma (CCA) (P = 0.001) in a hamster model, which correlated with the results of mRNA in situ hybrid-ization. An immunohistochemical analysis of 60 CCA patients revealed a significant increase of MARCKS expression. Moreover, the log–rank analysis indicated that CCA patients with a high MARCKS expression have significantly shorter survival times than those with a low MARCKS expression (P = 0.02). This study investi-gated whether MARCKS overexpression is associated with CCA metastasis. Using a confocal microscopic analysis of CCA cell lines that had been stimulated with the PKC activator, 12-0-tetradeca-noyl phorbol-13-acetate (TPA), MARCKS was found to be translo-cated from the plasma membrane to the perinuclear area. In addition, phosphorylated MARCKS (pMARCKS) became highly con-centrated in the perinuclear area. Moreover, an adhesion assay demonstrated that the exogenous overexpression of MARCKS remarkably promoted cell attachment. Interestingly, after TPA stimulation, the CCA cell line-depleted MARCKS showed a decrease in migration and invasion activity. It can be concluded that in non-stimulation, MARCKS promotes cell attachment to the extracellular matrix. After TPA stimulation, PKC phosphorylates MARCKS leading to cell migration or invasion. Taken together, the results of this study reveal a prominent role for MARCKS as one of the key players in the migration of CCA cells and suggest that cycling between MARCKS and pMARCKS can regulate the metasta-sis of biliary cancer cells. (Cancer Sci 2010; 101: 658–665) C holangiocarcinoma (CCA), the malignant tumor arisingCancer Science 05/2010; 101(3):658-665. · 3.48 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: To evaluate the role of thymidine phosphorylase (TP) in cholangiocarcinoma using small interfering RNA (siRNA). A human cholangiocarcinoma-derived cell line KKU-M139, which has a naturally high level of endogenous TP, had TP expression transiently knocked down using siRNA. Cell growth, migration, in vitro angiogenesis, apoptosis, and cytotoxicity were assayed in TP knockdown and wild-type cell lines. TP mRNA and protein expression were decreased by 87.1% + or - 0.49% and 72.5% + or - 3.2%, respectively, compared with control cells. Inhibition of TP significantly decreased migration of KKU-M139, and suppressed migration and tube formation of human umbilical vein endothelial cells. siRNA also reduced the ability of TP to resist hypoxia-induced apoptosis, while suppression of TP reduced the sensitivity of KKU-M139 to 5-fluorouracil. Inhibition of TP may be beneficial in decreasing angiogenesis-dependent growth and migration of cholangiocarcinoma but may diminish the response to 5-fluorouracil chemotherapy.World Journal of Gastroenterology 04/2010; 16(13):1631-8. · 2.43 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Liver cancer is the most common cancer in males in Thailand and the third in females. A high incidence of cholangiocarcinoma (CCA) is estimated in the northeast of Thailand. Chronic infection with Opisthorchis viverrini (OV) is the major risk factor for development of CCA. It has been demonstrated that HCV infection is a risk factor for CCA in non - endemic area of OV infection. We examined the association of HBV and HCV and risk of CCA in the northeast Thailand. All cases of CCA were recruited between 1999 and 2001 from Nakhon Phanom provincial hospital and all community hospitals in the province. One control per case was selected, matched by sex, age (∓5 years) and residence. 106 case-control pairs were obtained. Anti-OV, HBsAg, and Anti HCV were determined by ELISA. Among 103 age-sex-place of residence matched case-control pairs, there were 7, 0, 0, 96 pairs for anti-HCV (+) case vs. (-) control, (+) case vs. (+) control, (-) case vs. (+) control and (-) case vs. (-) control combinations (OR=7/0). Among 106 matched pairs, there were 9, 2, 4, 91 pairs for the similar four combinations of HBsAg (OR=2.25 (95%CI: 0.63-10.0). If the subject had anti-HCV and/or HBsAg, the OR for CCA was 4.00 (95%CI: 1.29-16.4). Even after adjustment for anti-OV, risk for HBsAg and/or anti-HCV positive was still marginally increased with an OR of 4.69 although not reaching statistical significance (95%CI: 0.98-22.5). Hepatitis B and C virus infection may also play role in the development of CCA in northeast Thailand.Asian Pacific journal of cancer prevention: APJCP 01/2010; 11(4):985-8. · 1.50 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Adult T-cell leukemia/lymphoma (ATL) is characterized by monoclonal proliferation of tumor cells that harbor integrated human T-cell leukemia virus type-1 (HTLV-1). These malignant cells accumulate in various organs including the liver, spleen and skin in addition to blood and lymph nodes. Although there have been several reports of animal models of HTLV-1 infection in which proviral distribution has been examined, clonal expansion of the experimentally infected host cells has not been extensively analyzed. Here we provide experimental evidence that clonal proliferation of the infected host cells occurs in the spleen for more than one year. During a 15 month period of persistent infection, two out of ten mice developed spontaneous tumors. Although the tumors were not ATL-like, cells exhibiting mono- or oligoclonal proliferation and having the same site of HTLV-1 integration were identified in tumor tissues as well as in the spleen. Quantitative analysis of the cells belonging to each cell clone suggested that these proliferating cell clones were associated with the tumors and that spontaneous tumor tissues might provide a suitable microenvironment for proliferation and accumulation of infected cell clones at the late stage of infection.International Journal of Oncology 11/2009; 35(4):701-7. · 2.77 Impact Factor -
Article: Neuraminidase enhances the initial steps of human T-cell leukemia virus type 1 replication.
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ABSTRACT: Human T-cell leukemia virus type 1 (HTLV-1) infection is involved in the development of adult T-cell leukemia and HTLV-1-associated myelopathy/tropical spastic paraparesis. A high HTLV-1 proviral load in circulating lymphocytes of HTLV-1 carriers is a risk factor for HTLV-1-related diseases. The virus-cell interaction is linked to viral tropism and pathogenesis. Characterization of the factors that affect HTLV-1 infection is important for preventing HTLV-1 infection. HTLV-1 virions are believed to be weakly infectious under cell culture conditions; however, we found that the treatment of HTLV-1 virions with microbial neuraminidase, an enzyme catalyzing the removal of sialic acid residues from various glycoconjugates, enhanced the number of proviral DNAs in infected cells in a dose-dependent manner. Neuraminidase treatment of virions, but not target cells, enhanced viral binding and entry into cells and viral infectivity; treatment of target cells prior to infection had no effect. Moreover, the number of HTLV-1-mediated syncytia was higher in the presence of neuraminidase. Our results suggest a possible contribution of microbial agents carrying neuraminidase activity to HTLV-1 pathogenesis.Microbes and Infection 11/2009; 12(2):119-25. · 2.73 Impact Factor
Publication Stats
4k | Citations | |
734.25 | Total Impact Points | |
Top Journals
Nagahama Institute of Bio-Science and Technology
Нагахама, Shiga, Japan -
National Institute of Advanced Industrial Science and Technology
Tsukuba, Ibaraki, Japan
Khon Kaen University
- Faculty of Medicine
Khon Kaen, Changwat Khon Kaen, Thailand
National Cancer Institute Thailand
Krung Thep, Bangkok, Thailand
Mahidol University
- Faculty of Medical Technology
Bangkok, Bangkok, Thailand
University of Tsukuba
- Institute of Basic Medical Sciences
Tsukuba, Ibaraki-ken, Japan -
Tufts University
- Department of Developmental, Molecular and Chemical Biology
Medford, MA, United States
Chulalongkorn University
- Institute of Health Research
Krung Thep, Bangkok, Thailand
Jichi Medical University
- Department of Pediatrics
Tochigi, Tochigi-ken, Japan
University of Shizuoka
- • School of Pharmaceutical Sciences
- • Department of Biochemistry
Shizuoka-shi, Shizuoka-ken, Japan -
The University of Tokyo
Tōkyō, Japan
National Defense Medical College
- Division of Obstetrics and Gynecology
Tokorozawa, Saitama-ken, Japan
Kansai Medical University
- Department of Medical Chemistry
Moriguchi, Osaka-fu, Japan
National Cancer Center, Japan
- Endoscopy Division
Edo, Tōkyō, Japan
National Hospital Organization Kyushu Cancer Center
Hukuoka, Fukuoka, Japan


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Ecuador officials reject donkey as candidate
QUITO, Ecuador (AP) - The demand of dozens of citizens has been denied in the Ecuadorean city of Guayaquil: There will be no jackass running for the legislature.
At least 40 people paraded their candidate through the city's streets to the electoral council offices. Mr. Burro even wore a tie. But officials refused to even let them in the door on Thursday, even though backers had dummied up a mock voter registration card showing the candidate's photo superimposed on a man wearing a business suit.
Donkey backer Daniel Molina told local television stations the goal was to call voters' attention to the seriousness of the February election, not to insult any party.
(Copyright 2012 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.)
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Yell has launched a new mobile application and mobile internet site, putting it head to head with services offered by Google and Yahoo.
The application provides full access to Yell's listings, while also keeping track of regular requests, providing an auto-suggest function, and letting users 'click to call' businesses. It also provides zoomable maps, and lets users save info to their Contacts, or send it to friends via SMS.
Techscape has a full report on the new application, including Yahoo's views on flat-rate data tariffs, making it work with GPS-equipped handsets in the future, and how advertising fits in.
Other Common News:1) Marketing deal could generate more mobile ads2) First secure SMS-based mobile payment service deployed3) Mobile Content Deals: Brew Gaming Launch, Designer Mobile, Mobile Premiers For Singles4) Zannel launches mobile entertainment network5) Kirusa(Indian Voice SMS Co.) Gets $10 Million In Funding


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I've been at this for hours, I've checked all over the web and I've found things that have helped, but I can't seem to get the result I'm after.
I'm trying to make a simple game using css animations. I've split the the screen into 9 equal divs in rows of 3. I want you to start in the center block and when you click a button in another div your "ship" goes to that div and stays there until another button is clicked.
I've managed to get the ship to move however, when I try to add rotation to it to give it a "roll" effect of an actual plane, it dive bombs through the animation on the set rotation degree. I want the game to scroll along z-axis for a pseudo-3D look. kind of like the old top down vertical scrolling shooters except 3D-ish.
animation-name : cssAnimation;
animation-duration : 1s;
animation-iteration-count : 1;
animation-timing-function : ease;
animation-fill-mode :;
-webkit-animation-name : cssAnimation;
-webkit-animation-duration : 1s;
-webkit-animation-iteration-count : 1;
-webkit-animation-timing-function : ease;
-webkit-animation-fill-mode :;
-ms-animation-name : cssAnimation;
-ms-animation-duration : 1s;
-ms-animation-iteration-count : 1;
-ms-animation-timing-function : ease;
-ms-animation-fill-mode :;
@-webkit-keyframes cssAnimation {
0% {
-webkit-transform: rotate(0deg) scale(1) skew(0deg) translateX(0%);
75% {
-webkit-transform: rotate(15deg) scale(1) skew(0deg) translateX(-225%);
100% {
-webkit-transform: rotate(0deg) scale(1) skew(0deg) translateX(-225%);