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Genetic Disorders Related Articles & Blog Posts
Diagnosis in the 21st Century
Back in 1995, a man died tragically when he was only 42 years old. The official diagnosis was liver failure from alcoholic cirrhosis. No autopsy was done. The body was cremated. No clues remained. End of story. Or was it?Read full story
DiGeorge Anomaly
My five-year-old daughter has DiGeorge syndrome. Her T and B lymphocyte counts are normal, but she gets infections all the time — ear infections, sinus infections, pneumonia. It seems like she is always on antibiotics — sometimes the strong…Read full story
Hemihypertrophy and Cancer
Is it true that people with hemihypertrophy are more likely to get cancer?Read full story
Hemihypertrophy & Hemihyperplasia
Hi, Dr. Greene, I'm hoping that you can help me find some information on the subject of hemihypertrophy. Like I told you in chat, my darling daughter Jemma was diagnosed at the age of 4 months. She is now…Read full story
What is hemihypertrophy?Read full story
Dupuytren's Contracture and Plantar Fibromatosis
Dr. Greene, my 14-year-old daughter Jaymie has been diagnosed with a connective tissue disorder. The disease has two names — Dupuytren's contracture in the hands, and Plantar fibromatosis in her feet. We have been told that before she graduates…Read full story
Dupuytren's Contracture
What is Dupuytren's contracture?Read full story
Grebe Syndrome
Dr. Greene, Wonderful home page! I am the editor of a chain of newspapers in South Alabama and this morning a woman came into my office with a most interesting story. Her daughter is five months pregnant and recently…Read full story
Chances Of Having A Second Baby With Trisomy 13
Thank you so much for answering my question about trisomy 13. I finally understand. We were tested for our chromosomes for a translocation, and both parents were found to be normal. But what you said has me sort of…Read full story
Information on Trisomy 13
My baby boy died the day after he was born (March 22, 1997). He had trisomy 13 translocation. With that came a lot of physical defects, some being ventricular and atrial septal defects and a double outlet right ventricle….Read full story


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Comments from Mr. Winky
|Story title
|2012-10-02 23:50:11
|Case Study 301: My daddy told us to push his salty white pee back and forth between our mouths.
|loved the young girls out in the woods naked playing with the vibrator made my johnson jump then pumped large load onto my belly
|2012-10-10 03:01:22
|Case Study 301: Mr. Bowen let a stream of pee right into my mouth
|your writing has gotten so much better. read every chapter of this story and i loved it. so does Farah have to fuck the FBI Agent to get away. she should get pregnant
|2012-12-22 10:10:56
|Case Study 301: Pink Polka Dot Daisy Dukes
|waited a month for this story and holy fucking shit it was worth the wait. little longer than expected but i couldn't stop reading it. damn this was intense as hell. now i can't wait to see where you take us next
|2013-04-01 15:52:47
|Case Study 301: A daughter's Rebel Yell
|This story is da shit ;) could you get back to doing the Secrets of an officers daughter series? You should publish and make film.
|2013-09-26 00:58:40
|Case Study 301: My first webcast makes me a Star!
|Jin where the hell did you go? It has been so long. Nice to see that your alive and kicking. Aside from a lengthy chapter it was worth the read. front page yet again. Man you don't disappoint. where do we go from here?

subset: commoncrawl


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The last true collaboration of John Lennon and Paul McCartney (writing together and harmonizing on vocals) was "I've Got A Feeling" off of "Let It Be," which would turn out to be The Beatles last album. The start of the song's written by McCartney, an ode to the soon to be Linda McCartney. Lennon h ... More >>
Brenner's on the Bayou is definitely one of Houston's best-kept secrets. Set against a hillside off Memorial Drive at Westcott, the gem of a restaurant directly overlooks the bayou, with extensive grounds that boast trickling water features, lushly rolling hills, a gazebo and winding walkways. It's ... More >>
The countdown continues! Yesterday we saw shadows eating Daniel O'Sullivan, kids stomping the yard to a Band of Skulls tune, gothic perfection from the Grave Babies, and two wonderful local entries by Kerry Beyer and Jennifer Grassman. Now it's time to look at some titans of the music industry, as w ... More >>
Third Ward singer Jewel Brown once worked for both Louis Armstrong and Jack Ruby.
Hotlanta is so hot that they can even turn their airport into a club. Stay with us. A few days ago, Ludacris announced that he will close his Asian/Singaporean restaurant, Straits, and embark on a new "restaurateur" opportunity: opening a "Chicken and Beer" restaurant inside of Atlanta's Hart ... More >>
This is not Roger StaubachBen Roethlisberger, Mark Sanchez, Jay Cutler, Aaron Rodgers. In an era where success in the NFL has never been more tied to quarterback play, those are your last four quarterbacks standing in the 2011 Playoffs. Most NFL fans see the elimination and subsequent absen ... More >>
This is why they pay Roger Goodell the big bucks. For a commissioner who quickly gained a reputation as a strict disciplinarian after taking over for Paul Tagliabue in August 2006 by throwing suspensions at his league's miscreants like so many nickels and dimes, the decision he makes regarding pun ... More >>
Two popular stage productions close this weekend: Theatre Southwest's The Seven Year Itch and the Alley's Mauritius, while the film festival Latin Wave: New Films from Latin America also winds down over at the Museum of Fine Arts, Houston. Houston Press theater reviewer D.L.Groover told fans to hurr ... More >>
A discussion of non-Christmas Christmas music
In Janice Law's quests for a judgeship, the fourth time was a charm -- and now an alarm for the rest of the courthouse
In family court, Judge Annette Galik presides over divorce and custody cases where sex, lies and videotape are part of everyday evidence and testimony. Now the face on the videotape is her own.
The Royal Crown Revue doesn't just lounge around


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Hey, sup!
I'm Felynea, but call me Fely if you'd prefer. I'm a self taught artist so I'm still learning a lot of artistic theory and I'm a bit slow at what I do but I'm always working hard to improve.
I'm currently getting a BA in Interactive Entertainment. I hope to have the skill set and knowledge to allow me to make my own games and professional concept art someday. I major in Games with a forte in pixel art, and game art assets and design.
Touhou and Pokemon seem to be a constant trend in my gallery. Other than that it's mostly original work of mine from my game designs or just random shite.


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November 26, 2014
Nov. 14, 2013
WASHINGTON (AP) - President Barack Obama says health insurance companies can continue to sell policies canceled under his health care law for at least one more year to existing customers.
Obama is trying to head off a political furor created by a wave of cancellation notices hitting people who buy their coverage individually, as well as some small businesses. Their current plans don't meet requirements of the new health care law.
White House officials say a letter going out to state insurance commissioners will specify that current plans sold to existing customers will not be considered out of compliance with the health care law in 2014.
The president noted that the first-month enrollment numbers in health care plans under his law are lagging and he isn't happy about it. He said that "we fumbled the roll-out" of the program. And he vowed to build a better health care system for every American and "get it right."
While the administration is granting new flexibility, it remains to be seen if state regulators and insurance companies will exercise the option.
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Andropause also known as male menopause,[1] is the result of a gradual drop in testosterone which is an androgen. When men get into their early 30s, they begin losing testosterone at a rate of one to two percent a year. According to the U.S. Census Bureau, approximately 4-5 million men have symptoms of low testosterone levels.
The condition "andropause" is currently not recognized by the World Health Organization. When andropause occurs it's considered to be a deficiency state in which the hormone testosterone goes below the normal range for an aging male.
Andropause is caused by the reduction of hormones testosterone and dehydroepiandrosterone in middle-aged men. Testosterone assists the male body in building protein and is crucial for normal sexual drive and stamina. Testosterone also contributes to several metabolic functions including bone formation, and liver function. Adropause is also associated with a decrease in Leydig cells.[2] A steady decline in testosterone levels with age (in both men and women) is well documented.[3]
Symptoms that are caused by the reduction of male hormone testosterone are:[4]
- Anger and social withdrawal[5]
- Anxiety
- Back pain
- Depression[6]
- Erectile dysfunction
- Gynecomastia (male breasts)
- Hair Loss
- Head aches
- Hot Flashes
- Hypersensitivity
- Insomnia
- Irritability
- Lack of libido
- Low bone density[7]
External causes[edit]
External factors that can[9] cause testosterone levels to fall include certain forms of medication, poor diet, excessive alcohol consumption, illness, lack of sleep, lack of sex, stress or surgery. It can also be a symptom of neuroendocrine dysfunction after a mild traumatic brain injury.[10]
Internal Causes[edit]
Andropause is preceded by a condition called Hypogonadotropic hypogonadism.[11] A downturn in the circulation of testosterone should cause the hypothalamus and pituitary gland to trigger a release of brain hormones that stimulate the testicles to ramp up production of testosterone.[12]
Although, as men age, despite low Testosterone, the levels of gonadotropin-releasing hormone (GnRH) and luteinizing hormone (LH) will not rise. The luteinizing hormone, gonadotropic releasing hormone, and testosterone all are dropping below what's considered normal. Low GnRH, low LH, low testosterone indicate the syndrome of hypogonadotropic hypogonadism, and it is a downward trend that takes men closer to andropause. This phenomenon typically begins in the early forties.
Eventually, testosterone levels drop to such low levels, the hypothalamus and pituitary kick in and produce high levels of GnRH and LH to compensate. This triggers the production of testosterone, which will generally work for a while, but then will fall again. That's when men enter andropause. They have a low testosterone and a high LH and GnRH, whereas before they had a low testosterone as well as low LH and GnRH.
This shift in hormonal patterns occurs in all men at some point. The female version, a similar hormonal shift that occurs in women happens in a more narrow age grouping, from early forties to late fifties.[13]
As a "state"[edit]
The impact of low levels of testosterone has been previously reported. In 1944, Heller and Myers[14] identified symptoms of what they labeled the "male climacteric" including loss of libido and potency, nervousness, depression, impaired memory, the inability to concentrate, fatigue, insomnia, hot flushes, and sweating. Heller and Myers found that their subjects had lower than normal levels of testosterone, and that symptoms decreased dramatically when patients were given replacement doses of testosterone.
Andropause has been observed in association also with Alzheimer's disease.[15]
In one study, 98.0% of primary care physicians believed that andropause and osteoporosis risk were related.[16]
The term "symptomatic late onset hypogonadism" (or "SLOH") is sometimes considered to refer to the same condition as the word "andropause".[17][18]
Some researchers prefer the term "androgen deficiency of the aging male" ("ADAM"), to more accurately reflect the fact that the loss of testosterone production is gradual and asymptotic[19] (in contrast to the more abrupt change associated with menopause.[20]) The "D" is sometimes given as "decline" instead of "deficiency". In some contexts, the term "partial androgen deficiency in aging males" ("PADAM") is used instead.[21]
As a disorder[edit]
Proponents of andropause as a distinct condition claim that it is a biological change experienced by men during mid-life, and often compare it to female menopause. Menopause, however, is a complete cessation of reproductive ability caused by the shutting down of the female reproductive system. Andropause is a decline in the male hormone testosterone. This drop in testosterone levels is considered to lead to in some cases erectile dysfunction, diabetes, loss of energy and concentration, depression, and mood swings. While andropause does not cause a man's reproductive system to stop working altogether, many experience symptoms of it impotence.
"Age also significantly affects circulating testosterone concentrations. Until puberty, children do not experience an acute increase in testosterone from a bout of resistance exercise; after puberty some acute increases in testosterone from resistance exercise can be found in boys but not in girls. Aging beyond 35–40 years is associated with a 1–3% decline per year in circulating testosterone concentration in men."[22] The theory is that andropause is caused by a very gradual testosterone deficiency and an increase in sex hormone-binding globulin (SHBG) that occurs from age 40 onward. By contrast, women have a more rapid onset of menopause at an average age of 51. Testosterone declines 10% every decade after age 30 (1% per year).
What is known as premature andropause is theorized to occur in males who experience excessive female hormone stimulation through workplace exposure to estrogen. Men who work in the pharmaceutical industry, plastics factories, near incinerators, and on farms that use pesticides are high-risk for early andropause.[citation needed]
Proponents claim that by their mid-50s, about 30 percent of men experience andropause. It is thought that about 5 million American men do not produce adequate testosterone, which leads to early andropause. In Australia, about 1 in every 200 men under the age of 60 and about 1 in every 10 men over 60 have low testosterone. Regardless of location, the most likely males to develop early andropause are those with diabetes, hypertension, and genetic disorders that produce hypogonadism, including Klinefelter's, Wilson-Turner, and Androgen insensitivity syndromes.
Much of the current popular interest in the concept of andropause has been fueled by the book Male Menopause, written by Jed Diamond, a lay person.[23] According to Diamond's view, andropause is a change of life in middle-aged men, which has hormonal, physical, psychological, interpersonal, social, sexual, and spiritual aspects. Diamond claims that this change occurs in all men, generally between the ages of 40 and 55, though it can occur as early as 35 or as late as 65. The term "male menopause" may be a misnomer, as unlike women, men's reproductive systems do not cease to work completely in mid-life; some men continue to father children late into their lives (at age 90 or older[24]). But Diamond claims that, in terms of other life impacts, women's and men's experience are somewhat similar phenomena.[25][26][27]
The concept of andropause is perhaps more widely accepted in Australia and some parts of Europe than it is in the United States.[28]
Many clinicians believe that andropause is not a valid concept. Men can continue to reproduce into old age; their reproductive systems do not stop working completely in midlife, and therefore they do not exhibit the sudden and dramatic drops in hormone levels characteristic of women going through menopause.
Other clinicians have the opinion that andropause is simply synonymous with hypogonadism or unusually low testosterone levels.[27] There is opposition to the concept of andropause in Europe as well as the U.S.[29]
Some clinicians argue that many of the cited symptoms are not specific enough to warrant describing a new condition. For example, people who are overweight may be misguided into treating a new illness rather than addressing the lifestyle that led to their being overweight. Similarly, energy levels vary from person to person, and for people who are generally inactive, energy levels will automatically be lower overall.
While it is true that active and otherwise healthy men could in theory develop andropause-like symptoms, how common and widespread the phenomenon is, and whether genetics, lifestyle, environment, or a combination of factors are responsible, is not yet known.
Hormone replacement therapy[edit]
Testosterone levels (T-levels) decline gradually as humans age. Unlike females going through menopause, the decline in testosterone in men is gradual, and there is variation among individuals.[30] After reaching 80 years of age, the rate of testosterone secretion decreases about 50% for men.[30]
The clinical significance of this decrease is debated. There is disagreement between doctors about when and how to treat men with decreasing T-levels. The American Society of Andrology's position states testosterone replacement therapy is recommended when both clinical symptoms and signs of androgen deficiency (male equivalent of menopause) and decreased testosterone levels are present in aging men.[31]
Experts said the study, published in the September 12, 2013 issue of the New England Journal of Medicine,[32] deepens researchers' understanding of the hormonal shifts that occur as men age. Additionally, The American Association of Clinical Endocrinologists defines hypogonadism as a testosterone level that is below the lower limit of normal for young adult control subjects[33] Previously, age-related decreases in free testosterone were once accepted as normal.[34] Currently, they are not considered normal. [35] Patients with borderline testosterone levels warrant a clinical trial of testosterone according to some endocrinologists in 2003.[36] Researchers are skeptical about the simplicity of ads about "low T" and testosterone supplements and their impact on men.[citation needed] Instead, researchers conclude there is no black-and-white cutoff for "low" or "suboptimal" testosterone. Different symptoms show up at different testosterone thresholds: Muscle mass and strength do not decline until testosterone drops quite low (significantly below normal levels) whereas libido may dampen with relatively small decreases in the hormone. [37] According to Joel Finkelstein, associate director of the Bone Density Center at Massachusetts General Hospital in Boston, men's functioning is not impaired solely by a loss of testosterone, but by a loss of estrogen as well.[38]
Agreement on the threshold of testosterone values below which a man would be considered hypogonadal has not been reached (currently, there are no standards as to when to treat women). Testosterone can be measured as "free" (that is, bioavailable and unbound) or, more commonly, "total" (including the percentage that is chemically bound and unavailable). In the United States, male total testosterone levels below 300 ng/dl from a morning serum sample (most accurate measurement) are generally considered low.[citation needed] To confirm the low levels of testosterone, doctors recommend repeating the measurement of morning total testosterone.[citation needed] Identification of inadequate testosterone in an aging male by symptoms alone can be difficult, especially because many different factors can be involved.
Testosterone supplemental therapy is available in the form of topical gels, patches, and injections and can cost up to $300 a month.[39] Researchers at the Boston University School of Medicine, recommend testosterone therapy for men with androgen deficiencies who have low testosterone levels[40] Therapy allows men to maintain sex characteristics, which can improve their sexual function.[41] Testosterone supplemental therapy can also increase a sense of well being, muscle mass and strength, and bone density in men.[42]
Adverse effects[edit]
Adverse effects of testosterone supplementation may include increased cardiovascular events (including strokes and heart attacks) and deaths based on three peer-reviewed studies involving men taking FDA-approved testosterone-replacement.[43] In addition, an increase of 30% in deaths and heart attacks in older men has been reported.[44] Due to an increased incidence of adverse cardiovascular events compared to a placebo group, a Testosterone in Older Men with Mobility Limitations (TOM) trial (a National Institute of Aging randomized trial) was halted early by the Data Safety and Monitoring Committee.[45] On January 31, 2014, reports of strokes, heart attacks, and deaths in men taking FDA-approved testosterone-replacement led the Food and Drug Administration (FDA) to announce that it would be investigating the issue.[46] Later, in September 2014, the FDA announced, as a result of the "potential for adverse cardiovascular outcomes", a review of the appropriateness and safety of Testosterone Replacement Therapy (TRT).[47][48][49]
Other adverse effects of testosterone supplementation may include increased hematocrit (which may require venipuncture in order to treat), exacerbation of sleep apnea and acceleration of pre-existing prostate cancer growth in individuals having undergone androgen deprivation.[50] Adverse effects may also include minor side-effects such as acne and oily skin as well as significant hair loss and/or thinning of the hair which may be prevented with 5-alpha reductase inhibitors ordinarily used for the treatment of benign prostatic hyperplasia such as finasteride or dutasteride.[51]
Exogenous testosterone may also cause suppression of spermatogenesis, leading to, in some cases, infertility.[52] It is recommended that physicians screen for prostate cancer with a digital rectal exam and prostate-specific antigen (PSA) level before starting therapy, and monitor hematocrit and PSA levels closely during therapy.[53]
In popular culture[edit]
In the 154th episode of the animated television series King of the Hill ("The Incredible Hank"), Hank is diagnosed with irritable male syndrome, and is prescribed testosterone.[54]
In the 98th episode of the series "Yes, Dear" ("Jimmy Has Changed"), Jimmy is diagnosed with andropause after coming down with a case of the sweats and a decreased interest in sex.[55]
See also[edit]
- ^ "Male Menopause". Archived from the original on 12 December 2007. Retrieved 2007-12-17.
- ^ Mahmoud A, Comhaire FH (2006). "Mechanisms of disease: late-onset hypogonadism". Nat Clin Pract Urol 3 (8): 430–8. doi:10.1038/ncpuro0560. PMID 16902519.
- ^ Mooradian AD, Korenman SG (2006). "Management of the cardinal features of andropause". Am J Ther 13 (2): 145–60. doi:10.1097/01.mjt.0000132252.80403.c9. PMID 16645432.
- ^ Sternbach, Harvey (October 1998). "Age-Associated Testosterone Decline in Men: Clinical Issues for Psychiatry". American Journal of Psychiatry 155 (10): 1310–1318.
- ^ Lincoln G (2001). "The irritable male syndrome". Reprod Fertil Dev 13 (7-8): 567–76. doi:10.1071/RD01077. PMID 11999307.
- ^ http://www.ncbi.nlm.nih.gov/pubmed/12773956
- ^ http://webmedia.unmc.edu/alliedhealth/nichols/Andropause%20and%20Men.pdf
- ^ a b http://www.bodylogicmd.com/for-men/symptoms-of-andropause
- ^ "Male Menopause". www.nhs.uk. NHS Choices. Retrieved 15 October 2014.
- ^ "DCoE Clinical Recommendation | August 2012 Indications and Conditions for Neuroendocrine Dysfunction Screening Post Mild Traumatic Brain Injury". DCOE Defense Centers of Excellence. Retrieved 2 December 2013.
- ^ "Testosterone Deficiency (Primary Hypogonadism and Secondary/Hypogonadotrophic Hypogonadism)". What is Testosterone Deficiency. Virtual Medical Center.
- ^ Florence Comite (November 21, 2013). "Why You Should Avoid Carbs at Bedtime". Men's Health. Retrieved October 24, 2014.
- ^ "Hormonal Expression of Androgen Decline in Aging Men (ADAM)". Florence Comite. The Endocrine Society.
- ^ Heller, C.G., Myers, G.B., "The Male climacteric: Its symptomatology, diagnosis and treatment." JAMA 1944; 126:472-77.
- ^ Fuller SJ, Tan RS, Martins RN (2007). "Androgens in the etiology of Alzheimer's disease in aging men and possible therapeutic interventions". J. Alzheimers Dis. 12 (2): 129–42. PMID 17917157.
- ^ Pommerville PJ, Zakus P (2006). "Andropause: knowledge and awareness among primary care physicians in Victoria, BC, Canada". Aging Male 9 (4): 215–20. doi:10.1080/13685530601040661. PMID 17178557.
- ^ "Columbia Presbyterian - Department of Urology". Retrieved 2007-12-17.[dead link]
- ^ "There's help for "grumpy old men", but they're reluctant to admit to problem, says Queen's urologist". Retrieved 2007-12-17.
- ^ Morales A (2004). "Andropause (or symptomatic late-onset hypogonadism): facts, fiction and controversies". Aging Male 7 (4): 297–303. doi:10.1080/13685530400016664. PMID 15799125.
- ^ "What is Hypogonadism". AgeWait.
- ^ Tancredi A, Reginster JY, Luyckx F, Legros JJ (2005). "No major month to month variation in free testosterone levels in aging males. Minor impact on the biological diagnosis of 'andropause'". Psychoneuroendocrinology 30 (7): 638–46. doi:10.1016/j.psyneuen.2005.02.002. PMID 15854780.
- ^ "Testosterone physiology in resistance exercise and training: The up-stream regulatory elements.". Adis International.
- ^ Diamond, Jed (1998). Male Menopause. Naperville, Ill: Sourcebooks. ISBN 1-57071-397-9.
- ^ "Father, 90, shows off new baby" - timesonline.co.uk, retrieved 9/08/07
- ^ Cetel, Nancy (2002). Double Menopause: What to Do When Both You and Your Mate Have Hormonal Changes Together. New York: Wiley. ISBN 0-471-40262-1.
- ^ Diamond, Jed (2000). Surviving Male Menopause. A Guide for Women and Men. Naperville, Ill: Sourcebooks. ISBN 1-57071-433-9.
- ^ a b Tan, Robert S. (2001). The andropause mystery: unraveling truths about the male menopause. Houston, Tex: AMRED Pub. ISBN 0-9707061-0-3.
- ^ Carruthers, Malcolm (2004). Androgen Deficiency in the Aging Male. London: Taylor & Francis Group. ISBN 1-84214-032-9.
- ^ Juul, A.; Skakkebaek, N. E. (2002). "Testosterone treatment of elderly men. The so called andropause doesn't exist.". Ugeskr. Laeg. (in Danish) 164 (42): 4941–2. PMID 12416079.
- ^ a b Borst, S.E.; Mulligan, T (2007). "Testosterone Replacement Therapy for Older Men". Clinical Interventions in Aging 4 (2).
- ^ "Harvard Medical School and Harvard Health Publication", A Harvard expert shares his thoughts on testosterone-replacement therapy, March, 2009
- ^ "The New England Journal of Medicine", Mechanisms of Action of Testosterone — Unraveling a Gordian Knot, September 12, 2013
- ^ "US National Library of Medicine, National Institutes of Health", Differential effects on bone of estrogen receptor α and androgen receptor activation in orchidectomized adult male mice, October 22, 2003
- ^ [ http://www.usrf.org/breakingnews/on020904-testosterone_doubt/on020904-testosterone_doubt.html/ "New Yorker Magazine", Questions Value of Testosterone Supplementation in Men with "Male Menopause", July 29, 2002]
- ^ "MedPage Today", Testosterone Decline With Aging: What Is Normal?, October 3, 2012
- ^ Guay AT, Spark RF, Bansal S, Cunningham GR, Goodman NF, Nankin HR, Petak SM, Perez JB (2003). "American Association of Clinical Endocrinologists medical guidelines for clinical practice for the evaluation and treatment of male sexual dysfunction: a couple's problem—2003 update". Endocr Pract 9 (1): 77–95. doi:10.4158/EP.9.1.77. PMID 12917096.
- ^ "WebMD", Testosterone Not the Whole Story in 'Male Menopause', September 11, 2014
- ^ "US National Library of Medicine, National Institutes of Health", Differential effects on bone of estrogen receptor α and androgen receptor activation in orchidectomized adult male mice, October 22, 2003
- ^ https://postgradmed.org/doi/10.3810/pgm.2013.03.2637
- ^ "Endocrine Society", Endocrine Society Tells FDA Testosterone Therapy Should Only Be for Men with Hypogonadism, September 17, 2014
- ^ "Endocrine Society", Endocrine Society Tells FDA Testosterone Therapy Should Only Be for Men with Hypogonadism, September 17, 2014
- ^ Bhasin, S.; Cunningham, G.R; Hayes, F.J; Matsumoto, A. M; Snyder, P.J; Swerdloff, R.S; Montori, V.M (2010). "Testosterone Therapy in Men with Androgen Deficiency Syndromes: An Endocrine Society Clinical Practice Guideline". The Journal of Clinical Endocrinology and Metabolism 95 (6). doi:10.1210/jc.2009-2354.
- ^ Finkle WD, Greenland S, Ridgeway GK, Adams JL, Frasco MA, Cook MB, Fraumeni JF, Hoover RN (January 2014). "Increased Risk of Non-fatal Myocardial Infarction Following Testosterone Therapy Prescription in Men". PLoS ONE 9 (1): e85805. doi:10.1371/journal.pone.0085805. PMC 3905977. PMID 24489673.
- ^ Vigen R, O'Donnell CI, Barón AE, Grunwald GK, Maddox TM, Bradley SM, Barqawi A, Woning G, Wierman ME, Plomondon ME, Rumsfeld JS, Ho PM (2013). "Association of testosterone therapy with mortality, myocardial infarction, and stroke in men with low testosterone levels". Journal of the American Medical Association 310 (17): 1829–36. doi:10.1001/jama.2013.280386. PMID 24193080.
- ^ Basaria S, et al. (Jul 2010). "Adverse Events Associated with Testosterone Administration". New England Journal of Medicine 363 (2): 109–22. doi:10.1056/NEJMoa1000485. PMC 3440621. PMID 20592293.
- ^ Staff (January 31, 2014). "FDA evaluating risk of stroke, heart attack and death with FDA-approved testosterone products" (PDF). U.S. Food and Drug Administration. Retrieved September 17, 2014.
- ^ Tavernise, Sabrina (September 17, 2014). "F.D.A. Panel Backs Limits on Testosterone Drugs". New York Times. Retrieved September 18, 2014.
- ^ Staff (September 5, 2014). "FDA Panel To Review Testosterone Therapy Appropriateness and Safety". CNN News. Retrieved September 14, 2014.
- ^ Staff (September 17, 2014). "Joint Meeting for Bone, Reproductive and Urologic Drugs Advisory Committee (BRUDAC) and the Drug Safety And Risk Management Advisory Committee (DSARM AC) - FDA background documents for the discussion of two major issues in testosterone replacement therapy (TRT): 1. The appropriate indicated population for TRT, and 2. The potential for adverse cardiovascular outcomes associated with use of TRT" (PDF). Food and Drug Administration. Retrieved September 14, 2014.
- ^ [ http://www.ncbi.nlm.nih.gov/pubmed/23395803/ "PubMed.gov", Testosterone replacement therapy in patients with prostate cancer after radical prostatectomy, February 8, 2013]
- ^ [ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4212439/ "Therapeutic Advances in Drug Safety", Adverse effects of testosterone replacement therapy: an update on the evidence and controversy, October 2004 ]
- ^ "Contraceptive efficacy of testosterone-induced azoospermia in normal men. World Health Organization Task Force on methods for the regulation of male fertility". Lancet 336 (8721): 955–9. October 1990. doi:10.1016/0140-6736(90)92416-F. PMID 1977002.
- ^ "National Academy of Sciences", Testosterone and Aging: Clinical Research Directions, 2004
- ^ "Episode plot "The Incredible Hank"". IMDb. Retrieved 30 August 2014.
- ^ "Episode plot "Jimmy has changed"". IMDb. Retrieved 30 August 2014.
External links[edit]
- Andropause at DMOZ
- independent advice on androgen deficiency
- Evaluation of Andropause
- PDF booklet discussing the condition
- information and self test
- Fields, S. (n.d.). Male PMS and Low Testosterone Levels Linked. (archive.org mirror)
- Kwiatkowski, J. Irritable male syndrome.(2003, January 28)
- Moody men blame their hormones (2002, February 27)


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Myth: Bicycling is a fringe activity in Miami.
Our pic of the day shoots down that idea pretty fast.
Fun facts:
40% – Percentage of U.S. adults that would commute by bike
if safe facilities were available (1995 Rodale Press Poll)
40% – Percentage of all trips in America that are shorter than 2 miles = a 10-minute bike ride or a 30-minute walk (1995 NPTS)
3 Responses to Pic O' the Day – Dispelling the Myth
Meghan says:
Well done! This is awesome.
Mari Chael says:
Fringe activity? Families, kids, and folk in their 80′s and older bike. What planet do these people who say it's a fringe activity come from?
Rog in Miami Gardens says:
It's the same view people have about transit, and I've never found anything more condescending when motorists say, "Oh, nobody uses public transportation," which, really what they mean by that is "nobody" they deem important or worth knowing uses public transportation because that is not what I see when I move around the tri-county area by bus, rail and bike. There are also stats to prove that thousands of South Floridians board our buses and trains everyday. #irksome
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families »
New Americans
Share Old Salem hosts Fourth of July nationalization ceremony (pictured above: The new citizens take their oath on July 4th.) Old Salem Museum and Gardens kicked off a day of Fourth of July activities lastRead More »
Proposed scholarship will be named for Flack
Share (pictured above: Dr. Sylvia A. Flack heads the Center of Excellence for the elimination of Health Disparities at Winston-Salem State.) The "How is Your Heart Project" recently brought together 35 people from neighborhoods, businesses,Read More »
High hopes for new ICRCM leader
Share Lacy Ward Jr. has been named the new executive director of the International Civil Rights Center & Museum (ICRCM) in Greensboro. His appointment, effective May 19 will entail working with the board, employees,Read More »
Walk/run to promote good health, nonprofit agency
Share Once again, El Buen Pastor Latino Community Services will host the El Buen Camino 5K race and one-mile walk. Participants will gather on Saturday, April 5 at 9 a.m. on the campus ofRead More »
School hopes for voucher onslaught
Share As the debate about the viability, fairness and effectiveness of a state-supported school voucher plan rages, at least one local private school is preparing to welcome what it hopes will be an influxRead More »
War on Kwanzaa?
Share Hundreds of local residents attended Kwanzaa celebrations this week and last week at several venues throughout the city. Folks danced, laughed, fellowshipped and positively reflected on the tumultuous road African Americans have travelled.Read More »
Triad hopefuls eyeing Watt's seat
Share With U.S. Rep. Mel Watt's confirmation last week to head the Federal Housing Finance Agency, there will soon be a new face representing the state's 12th Congressional District for the first time inRead More »


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Maryam Y Naim, MD
Assistant Professor of Anesthesiology and Critical Care at the Hospital of the University of Pennsylvania and the Children's Hospital of Philadelphia
Department: Anesthesiology and Critical Care
Contact information
The Children's Hospital of Philadelphia
Department of Anesthesiology and Critical Care Medicine
34th Street & Civic Center Boulevard
Philadelphia, PA 19104
Office: 215-590-5505
Fax: 215-590-4327
Pre Med
Mander-Portman Woodward, London, 1994.
Aga Khan University Medical School Karachi, Pakistan, 1999.
Post-Graduate Training
Residency, Pediatric and Adolescent Medicine, Mayo Graduate School of Medicine, Rochester, MN, 2001-2004.
Fellowship, Pediatric Critical Care Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA, 2004-2007.
Fellowship, Pediatric Cardiac Intensive Care, The Children's Hospital of Philadelphia, Philadelphia, PA, 2007-2008.
CertificationsPermanent link
American Board of Pediatrics, 2014.
Advanced Cardiac Life Support (ACLS), 2015.
American Academy of Pediatric Critical Care Medicine, 2015.
Pediatric Advanced Life Support (PALS), 2015.
Advanced Trauma Life Support (ATLS), 2016.
Selected PublicationsRossano JW, Naim, MY: The nebulous relationship between volume and outcome. Resuscitation 85(11): 1642-1643, November 2014.
Friess SH, Sutton RM, French B, Bhalala U, Maltese MR, Naim MY, Bratinov G, Rodriguez SA, Weiland TR, Garuccio M, Nadkarni VM, Becker LB, Berg RA: Hemodynamic directed CPR improves cerebral perfusion pressure and brain tissue oxygenation. Resuscitation 85(9): 1298-1303, Septmeber 2014.
Sutton RM, Friess SH, Maltese MR, Naim MY, Bratinov G, Weiland TR, Garuccio M, Bhalala U, Nadkarni VM, Becker LB, Berg RA: Hemodynamic-directed cardiopulmonary resuscitation during in-hospital cardiac arrest resuscitation. Resuscitation 85(8): 983-986, August 2014.
Schwartz SM, Lu M, Ohye RG, Hill KD, Atz AM, Naim MY, Williams IA, Goldberg CS, Lewis A, Pigula F, Manning P, Pizarro C, Chai P, McCandless R, Dunbar-Masterson C, Kaltman JR, Kanter K, Sleeper LA, Schonbeck JV, Ghanayem N; for the Pediatric Heart Network Investigators: Risk factors for prolonged length of stay after the stage 2 procedure in the single-ventricle reconstruction trial. J Thorac Cardiovasc Surg 147(6): 1791-1798, June 2014.
Naim MY, Lynch JM , Buckley E, Busch D, Yodh A, Licht DJ: Pre-operative cerebral oxygen metabolism and blood flow in neonates with HLHS and TGA. Critical Care Medicine May 2014 Notes: Poster Presentation at 50 Years of Innovation in Pediatric Anesthesia and Critical Care Medicine: Where Do We Go From Here?, May 1, 2014, Union League, Philadelphia, PA
Lynch J, Buckley EM, Schwab P, McCarthy AL, Winters ME, Busch DR, Xiao R, Goff DA, Nicolson S, Montenegro L, Fuller S, Gaynor JW, Spray T, Yodh AG, Naim MY, Licht DJ: Pre-operative cerebral hemodynamics in infants with critical congenital heart disease. Biomedical Optics April 2014 Notes: Conference Paper: Poster Presentation at Biomedical Optics Conference, Miami, FL, April 2014
Naim MY, Gaynor JW, Chen J, Nicolson SC, Fuller S, Spray TL, Dlugos DJ, Clancy RR, Vianez L, Licht DJ, Abend NS: Subclinical seizures identified by postoperative electroencephalographic monitoring are common following infant cardiac surgery. 94th Annual Meeting of American Association for Thoracic Surgery, Toronto, ON, Canada April 2014 Notes: Oral Presentation
McCarthy AL, Busch DR, Lynch JM, Winters ME, Yodh AG, Licht DJ, Naim MY: Optical monitoring of blood flow during extra-corporeal membrane oxygenation therapy. Biomedical Optics April 2014 Notes: Conference Paper: Poster Presentation at Biomedical Optics Conference, Miami, FL, April 2014.
Jain V, Buckley E, Licht D, Lynch J, Schwab P, Naim, MY, Lavin N, Nicolson S, Montenegro L, Yodh A, Wehrli F: Cerebral oxygen metabolism in neonates with congenital heart disease quantified by MRI and optics. Journal of Cerebral Blood Flow and Metabolism 34(3): 380-388, March 2014.
Naim MY: Delaying heart surgery in newborns may rise risk for brain injury. Cardiology Today Newspaper March 2014 Notes: http://www.healio.com/cardiology/pediatric-cardiology/news/online/{87cb5beb-5ce8-4b82-a0c0-8c19f10444b1}/delaying-heart-surgery-in-newborns-may-raise-risk-for-brain-injury.
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Last updated: 10/20/2014
The Trustees of the University of Pennsylvania


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The South Asia Channel
Nine Killed in Attack on Luxury Kabul Hotel; Modi, Advani to Contest Seats in Gujarat; Pakistan to Import Electricity from India
Bonus Read: "How Indian Youth Are Shaking Up the 2014 Election," Sriram Balasubramanian (SouthAsia).
Nine killed in attack on Kabul hotel
At least nine people were killed and six were injured inside Kabul's luxury Serena Hotel on Thursday night when four teenagers entered the building's restaurant and opened fire, shooting patrons indiscriminately (Pajhwok, Reuters, TOLO News, WSJ). According to reports, the victims were a mix of Afghans and foreigners, children and adults. Sediq Sediqi, Afghanistan's Interior Minister, said that four foreign nationals from Canada, New Zealand, Pakistan, and India were among the victims, while Pajhwok Afghan News reported that a former Paraguayan diplomat was killed in the attack as well (AP, Pajhwok). The Agence France Presse wire service also announced that its Kabul reporter, Sardar Ahmad, his wife, and two of his three young children died in the attack; the third is still in critical condition (Pajhwok, RFE/RL).
Afghan police said they believe the gunmen entered the hotel, smuggling small pistols in their shoes, and hid in the bathroom for several hours before launching the attack (CNN, VOA). All four were killed in an ensuing shootout with Afghan security forces.
Zabihullah Mujahid, a Taliban spokesman, claimed responsibility for the assault and said the attackers had fired at hotel guests that were celebrating the Afghan new year. According to the BBC, the Afghan government has also blamed the attack on Pakistan's recent ceasefire with the Taliban, saying that it has allowed the militants to focus on targeting Afghanistan instead (BBC).
The heavily fortified Serena Hotel, considered one of the most secure buildings in the Afghan capital, is frequently used by foreign officials, wealthy Afghans, and development workers, and has been a frequent target of insurgent attacks (NYT).
More detainees released from Parwan Detention Center
The Afghan panel reviewing the cases of the remaining prisoners at the Parwan Detention Center at Bagram Airfield released 55 more inmates on Thursday, including 40 that had been detained by British forces in Helmand province (Pajhwok). The releases come just one month after Afghanistan's Attorney General Office freed 65 other prisoners, despite strong opposition from the United States.
Abdul Shakoor Dadras, a member of the panel, told reporters that 15 prisoners had denied having any connection with insurgents and that there was no incriminating evidence against the inmates that had been arrested by the British. However, Dadras also noted that: "We can't say who will join or who will not join the insurgent group" (TOLO News).
650 inmates have been released since the facility was transferred to the Afghans in 2012, and the cases of a further 48 prisoners are under review.
-- Bailey Cahall
Modi, Advani to contest seats in Gujarat
Narendra Modi, the prime ministerial nominee for India's opposition Bharatiya Janata Party (BJP), will contest a second parliamentary seat in Vadodara, in his home state of Gujarat, according to the BJP's fifth list of candidates (NYT). The BJP announced on Mar. 15 that Modi will run for a seat in the Lok Sabha, the lower house of parliament, from Varanasi, Uttar Pradesh. India's Election Commission allows candidates to run for a maximum of two seats. If a candidate wins both seats, he or she has to vacate one within 10 days and allow a by-election to take place in the district.
The party list also assigned BJP senior leader Lal Krishna Advani to a seat in Gandhinagar in the northern state of Gujarat, a decision that reportedly sparked opposition from Advani himself and caused controversy within the party (BBC, The Hindu, Hindustan Times).
Advani, a founding member of the BJP and a former deputy prime minister, had initially requested to contest a seat from Bhopal, Madhya Pradesh. On Wednesday, however, the BJP overruled his request and announced his candidacy from Gandhinagar. Modi then met with Advani on Thursday to persuade him to rethink the decision. The BJP later relented, with President Rajnath Singh releasing a statement saying it was up to Advani to choose between Gandhinagar, the constituency he has represented for five terms, and Bhopal, the seat he wanted. "It is the unanimous view of the party that the choice of where to contest from should be left to Advaniji himself," Rajnath said.
Advani has long held ambitions to become the BJP's prime ministerial candidate, and reportedly shares an uneasy relationship with Modi. Last year, Advani briefly quit the BJP after Modi was appointed to head its election campaign, saying the party's current leaders were "now concerned with their personal agendas." He later withdrew his resignation at the urging of senior party leaders.
In the ruling Congress party, Finance Minister P. Chidambaram announced that he will not contest the general elections next month. A list of 50 names released by the party on Thursday night showed that his son, Karti P. Chidambaram, will be named as the Congress candidate from the Sivanganga constitutency in Tamil Nadu instead (NDTV, Economic Times). Chidambaram is the third senior congressmen from the state of Tamil Nadu to opt out of the elections this year.
Four sentenced to life in Mumbai rape case
An Indian court on Friday sentenced four men to life in prison for gang-raping a receptionist, the first time a Mumbai court has handed down the maximum sentence for rape under India's new laws (Times of India, Economic Times, WSJ, Mint). Showing leniency in this case would "make a mockery of justice," the judges presiding in the case said.
Three of the men also await sentencing on Monday for the gang rape of a photojournalist last year. Under the penal code, these men could be sentenced as "repeat offenders in a rape case," a charge which carries the death sentence as a maximum punishment. The attack on the photojournalist came eight months after the gang rape and subsequent death of a student in New Delhi, which paved the way for new laws and stricter punishments aimed at safeguarding women.
India rejects Chinese help for Malaysia plane search
India has rejected a Chinese request to assist with the search for the missing Malaysian Airlines flight MH370 over concerns that the request might be an excuse for military spying (Indian Express, NDTV, Times of India). China had requested permission to allow four warships to enter the territorial waters of the Andaman Sea to locate the plane, which had 150 Chinese nationals on board. The Chinese Navy was told that the Indian Navy and Air Force were already scanning the area, government sources told the Press Trust of India.
India rejoined the search for the missing aircraft earlier this week, after receiving new search directions from Malaysia. India is ready to deploy long-range maritime surveillance aircraft, including the P-81 aircraft and C-130J Super Hercules aircraft, for search operations in a new search area south of Indonesia (WSJ).
-- Ana Swanson
Pakistan set to import electricity from India
A long-discussed electricity deal between India and Pakistan moved once step closer to finalization on Friday when Pakistan sent a draft power trade deal to India for its review (Dawn). According to reports, the draft was sent to India once the World Bank offered to finance a feasibility study and transmission line that would bring 1,200 megawatts of power from India to electricity-strapped Pakistan.
A senior government official, speaking on the condition of anonymity, said that Pakistan would initially import 500 megawatts of power, but would increase that to 1,200 megawatts over time. He added that the plan could be implemented within a year of laying the transmission line.
While India has expressed its intent to export electricity to Pakistan, if the requisite infrastructure is available, it has not yet commented on the draft deal (Economic Times).
Fears that Amjad Shahid Afridi has been kidnapped
Pakistan's Dawn newspaper reported on Friday that the family of Amjad Shahid Afridi, a senior bureaucrat, fears he has been kidnapped after his car was found abandoned on a motorway in Peshawar the day before (Dawn). Local police officials said Afridi was staying at a government-run guest house after being transferred from Islamabad to Khyber Pakhtunkhwa's provincial capital. While his latest assignment in the region has not yet been finalized, Afridi has previously served as the province's education secretary and secretary for information technology.
Three police officials guarding Pakistani Prime Minister Nawaz Sharif's farmhouse on the outskirts of Lahore were suspended for negligence this week after a cat devoured one of Sharif's peacocks (IBN). According to a police official, a gardener found the peacock's body on Tuesday and the incident was reported to the superintendent of police. While the men were indeed on guard, the police report noted that they "did not anticipate a cat eating the peacock at night." It is unclear if their suspensions are permanent, or what precautionary measures are being taken to protect the remaining birds.
-- Bailey Cahall
Edited by Peter Bergen.
SHAH MARAI/AFP/Getty Images


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Find records of Margaret Mills
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There are no known marriages or children on record for Margaret. Margaret died on May 23, 1997 at 87 years of age.
Margaret L Mills's last known residence is at Alton, Oregon County, Missouri.
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What to do if threatened by anthraxAfter the World Trade Center and Pentagon attacks in 2001, terrorism has become a more serious concern in the United States. One way that terrorists have targeted workplaces is by using the disease …Read Full Article
Knowing when to prepare a workplace for terrorist attacksTerrorist events on U.S. soil and ongoing threats emphasize the importance of emergency preparedness in the workplace. Certain companies and worksites are more susceptible to violence from extremists …Read Full Article


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United States Data Centers & Colocation Services Provider
Equinix United States Data Centers
More than 2,000 companies colocate in Equinix's data centers in the United States to connect to business partners and customers across their digital supply chains. Equinix's 45+ U.S. data centers are home to many thriving, diverse business ecosystems, including:
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Can I stay on the beach with one of these?
Gotta love the way he goes from wet to dry and back again!
Has anyone tried to lift a jetski before? They weigh a ton!
That's not, like, a proper ton.....but, like, very heavy!!!!
4 blokes to lift a coffin, a bloke and a jetski.......................
Only in America!!!
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Grandma's girls Eugenie and Louise join Queen at Easter service
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Hales proposes sales tax
Portland mayoral candidate Charlie Hales proposed a state sales tax to support the public school system.
OSU building $29M residence hall
Oregon State University officials expect to break ground next year on a $29 million residence hall.
Mozilla wants to open Portland office
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UO running out of room
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Office 2013: Screenshots
Summary: Microsoft's new Office has a design that makes it easy to focus on work, rather than drowning in extraneous information. Office 2013 looks set to make users more productive without requiring them to learn new ways of working, even on new kinds of devices.
9 of 16Image
Word (1)
When you launch an Office 2013 application without a document, it opens in a new Start screen view, where you can choose a template for your document — either using local files or an online document library.
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Excel (1)
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Thamesmead, St Paul, Thamesmead
- About Us
- Find Us
- Contact Us
- Services and Events
- Features and Facilities
- More Info
We are an ecumenical church (Anglican,Methodist and URC) who share a building with St Paul's Roman Catholic congregation.
For details of the Roman Catholic congregation, please visit http://directory.rcsouthwark.co.uk/thamesmead_central_stpaul.html
Parish boundary view Bird's eye view
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Rev Patrick Egglestone
Thamesmead Rectory
22 Manor Close
22 Manor Close
020 8312 0731 or 07788563253
- Regular Services
Praise & Worship
Congregational singing of West African Praise & Worship songs
Every Sunday at 9:15 AM for ½ hour
Parish Eucharist
Every Sunday at 9:45 AM for 1½ hours
Weekday Eucharist
Every Tuesday at 10:00 AM for ¾ hour
Bible Study
Every last Wednesday at 7:00 PM for 1 hour and 15 minutes.
Weekday Eucharist
Every last Wednesday at 8:15 PM for ½ hour
Prayer Meeting
Every Saturday at 9:00 AM for 1 hour
Other information
Clergy: The Revd Hugh {Patrick} EGGLESTON
A Church Near You ID (venue number): 843
Built: 1978
Architect: Hinton, Brown, Maddon & Langstone
Our Patron: The Bishop
Archdeaconry: LEWISHAM and GREENWICH (373)
Deanery: PLUMSTEAD (37302)
Benefice: Thamesmead (37/283BH)
Parish Legal Name: Thamesmead (370362 37/362)
CofE Church Info: (637242 37/362)
URL (web address): http://www.achurchnearyou.com/thamesmead-st-paul-ecumenical-centre/
Short URL: acny.uk/843/
QR Code:
Thamesmead, St Paul : Bentham Road, Thamesmead, London, SE2 8AS


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Subscription Deals
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Female Atlantic lobster stuffed with eggs found near Bowen Island
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City report backs Larwill Park site
Land deal contingent on the VAG securing funding by April 2015; Art Gallery's $300-million challenge
Darah Hansen, Vancouver Sun; With A File From Mike HagerPublished: Thursday, April 18, 2013
In January, senior city staff members held their own closed-door meeting attended by a roster of Canadian art and philanthropy experts to consider whether VAG's proposal is sound.
The current staff report is slated to go before council on April 23, with a vote expected the next day following public presentations on the issue.
Should it be approved, the report opens the doors for other arts and culture groups in Vancouver to actively pitch their own case on why they should be chosen to take over the VAG's existing site at 750 Hornby Street.
The Rattenbury building, as it is formally known, is owned by the province and leased to the City of Vancouver. The city has said it wants to retain the site for the cultural sector.
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Jane D. Giles, Director of Business Development, Cambey & West [advertiser in 30th issue]
"The whole issue is fab. Good work."
Company of the week
Data Services, Inc. meets the needs of today's data-driven marketer by providing front-end database management and data analytics platforms alongside our expertise in global contact data quality, database building and ongoing maintenance that comes with our 45+ years in business.


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Eric Cantor gets a new job...on Wall Street
Sabri Ben-Achour
Sep 2, 2014 The former house majority leader heads to boutique investment bank Moelis and Co.
How the Fed became a Central Superbank
Stacey Vanek Smith
Aug 20, 2014 Is it a bird? Its it a plane? No! It's the Federal Reserve!
"Buy the rumor, sell the news"
Nancy Marshall-Genzer
Aug 19, 2014 The truth behind the popular Wall Street phrase.
Wall Street tobacco deals left states in billions of debt
Cezary Podkul
Aug 7, 2014 Politicians wanted upfront cash from a victory over Big Tobacco, and bankers obliged.
Booming markets haven't translated to big profits on Wall Street
Stacey Vanek Smith
Jul 25, 2014 Lean days for Wall Street workers?
Inflation: A 'sweet spot' for consumer prices
Krissy Clark
Jul 22, 2014 The latest inflation numbers show prices are not too hot and not too cold.
Don't blame millennials. Blame the middle-aged!
Krissy Clark
Jul 17, 2014 Young Americans are buying houses at the same rate as they did in the 1990's.
'Stopgap' government frustrates feds and businesses
David Gura
Jul 15, 2014 Governing by crisis makes the federal government wasteful and inefficient.
Why do they still have floor traders at the NYSE?
Golda Arthur
Jul 4, 2014 Robots do most of the trading. So what's up with the folks in blue jackets?
An end to vulgar bankers
Sabri Ben-Achour
May 16, 2014 Deutsche Bank warns traders to stop being 'boastful, indiscreet and vulgar.'


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Check out our latest Mobile, Social, Messaging and Data Insights features.
These latest enhancements are designed to make it easier for restaurants to reach, understand, and engage their guests. From app improvements, to new data insights services, Paytronix continues deliver the tools restaurant marketers need to keep their most valuable guests.
Welcome to support! You're here for a reason so, we'll make it easy for you to find the answers you need.
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Download Software You will need your username and password to access the following downloads. Software packages are POS specific. If your POS is not listed below, please contact your Technical Support Representative.
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text:
|26 May 2012
Win7 Pro x64 & Win7 Ultimate x64
Win7 OEM re-activation due to hardware crash/replacement
As succinct as possible:
1. I have 2 computers - one running Windows 7 Pro x64 (main computer for work and gaming) and the other running Windows 7 Ultimate x64 (second computer)
2. Both Windows 7 installations are OEM.
3. The second computer has been sitting dead for close to a year because the motherboard died and I have not really wanted to spend money getting it running until now.
4. The route I am taking is to upgrade the main computer (motherboard, CPU, and RAM) and put the current "main" motherboard, CPU, RAM into the 2nd computer.
Logic would dictate that I ONLY upgrade the 2nd computer and make it the main computer. However, the Main computer has an SSD Hard Drive in it and the 2nd one does not. So, I'd prefer to keep the SSD HD for it's speed. That's why I've chosen this convoluted replacement process. There are other reasons for the convoluted process if you need elaboration let me know.
I did see a person ask about upgrading and keeping their license. I'm not sure if Microsoft views reasons for hardware changes due to failure differently. I suppose it's a matter of luck?
And thank you all for your time/effort.
|My System Specs
|26 May 2012
Win7 x 6 PC's
OEM license lives and dies with the mobo. Once you change mobo unless you use the exact same model it will fail reactivation. Any other hardware can be changed and should survive reactivation.
|My System Specs
|27 Aug 2013
Windows 7 ultimate x32
I have recently had to change motherboard on my dell laptop due to some video card problem. I have windows 7 installed on my machine and now getting reactivation problem. Please let me know how can i solve this problem as i had recently purchased windows 7 and dont want to purchase another license just for this problem.
Thanks, in advance
|My System Specs
|27 Aug 2013
Windows 7 Professional x64 Sp1
This is true
See above gregrocker response.
Also, you are replaying to a thread over a year old. Please create a new one.
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LAST CHANCE ANIMAL RESCUE INC Overview
Someone who had 3 hours of volunteer time could: Socialize/exercise kitties @ Petsmart, clean/sanitize kitty habitat @ Petsmart, contact all your friends on Facebook & ask them to donate/volunteer, drive to our HQ and play fetch with our rescued doggies, clean out your linen closet and bring us your old raggledy towels and blankets to use as kitty/doggie beds...email us for more ideas :o)
Geographic areas served: Washington, DC-MD-VA
Programs: Rescuing/Rehoming Homeless Shelter Pets Through a Partnership with PetSmart
Low-Cost Spay/Neuter Clinic
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Manicomio - Chelsea
- Address:
85 Duke of York Square, Chelsea
London, SW3 4LYNeighbourhood:
- Cuisine:
ItalianPrice: £26 to £40
Manicomio - Chelsea
- Dining Style: Casual Dining
- Website: http://www.manicomio.co.uk/chelsea/
- Phone: 020 7730 3366
- Hours of Operation:
Lunch: Monday - Friday: 12pm - 3:30pm; Saturday & Sunday: 12pm - 5pm
Dinner: Monday - Saturday: 6:30pm - 10:30pm; Sunday: 6:30pm - 10pm
- Payment Options: AMEX,MasterCard,Visa
- Cuisine: Italian
- Dress Code: Smart Casual
- Accepts Walk-Ins: Yes
- Additional Details: Bar Dining, Bar/Lounge, Cafe, Non-Smoking Restaurant, Patio/Outdoor Dining, Private Room, Takeout, Wheelchair Access, Wine
A word from Manicomio - Chelsea
Manicomio Restaurant is located at 85 Duke of York Square, just beside the the Saatchi gallery. The menu is seasonal modern Italian. All fish is line-caught and meat is provided by the Ginger Pig. Lunch and dinner are available throughout the week. The extensive heated terrace is perfect for balmy summer evenings or chilly nights. We have a well-stocked bar with classic cocktail menu and delicious selection of snacks to nibble alongside.Continued
Our deli, Manicomio Poco, is next door at number 83 serving breakfast, lunch, afternoon tea and light dinners. The Deli also offers a full take away menu including some of the finest Italian roast coffee in London as well as a selection of larger dishes for at-home dinners. The shop is perfect for gifts with an imaginative stock of store cupboard luxuries, kitchen equipment and books.
Private dining available in the extremely pretty conservatory.
Our deli, Manicomio Poco, is next door at number 83 serving breakfast, lunch, afternoon tea and light dinners. The Deli also offers a full take away menu including some of the finest Italian roast coffee in London as well as a selection of larger dishes for at-home dinners. The shop is perfect for gifts with an imaginative stock of store cupboard luxuries, kitchen equipment and books.
Private dining available in the extremely pretty conservatory.
Foodspotting photosSee all photos
Manicomio - Chelsea reviews from OpenTable diners
131 reviews since 25 November 2013
- Food4Service4
- Ambience3.8Value3.6
outdoor eating (70)business meals (42)special occasions (41)fit for foodies (40)romance (27)brunch (27)sunday lunch (24)pre/post theatre (20)good vegetarian options (20)group bookings (13)outstanding value (13)child friendly (11)disabled access (8)afternoon tea (5)Show More
- Delicious!!!!JimRDined on 21/11/2014We enjoyed an amazing meal...we especially loved the quail and chicken livers. The service was great, friendly and professional. We had a lovely time!!!Special Features:I would recommend this to a friend.
- ExcellentGJRTDined on 15/11/2014Friendly staff, personal attention to seating/booking requests. Delicious and beautifully presented food.Special Features:I would recommend this to a friend.
- Another terrific lunch at ManicomioPatrickWDined on 21/10/2014Have been here several times for lunch and dinner. Always excellent and the set lunch was terrific value - perfectly cooked cod on a bed or spicy puy lentils. Pushed to find anywhere as nice in this area. Highly recommended.Special Features:I would recommend this to a friend.
- Business dinner with atmosphereTheProfessorDined on 9/10/2014Manicomio is a favourite for Sunday lunch outside watching the people go by in Duke of York Square, but a recent business dinner inside confirmed the overall star quality of this restaurant: great service, good food and wine, reasonably priced and not so loud that you cannot hear your dining companions.Special Features:
- Genuine ItalianJandK2014Dined on 8/10/2014Friendly welcome, well situated table with comfortable seats, very attentive service, good choice of food and wine, expert Italian cuisine and reasonable prices - especially the set menus. Overall, a very happy dining experience.Special Features:I would recommend this to a friend.
- A very nice midweek night outAnaoreillyDined on 20/8/2014Good menu, friendly service and great location! Oh and good by the glass wine list too!Special Features:I would recommend this to a friend.
- Great Outdoor RestaurantChelseamomVIPDined on 16/7/2014I had lunch at Manicomio in Chelsea last month with a friend. It was the perfect weather to sit outside in front of the restaurant that is located in Duke of York's Square off the Kings Road. I chose this restaurant to host my friend as I have been many times and always have a delicious meal and this time was just the same. I can't wait to go back.Special Features:
- Birthday BashlyndaweaDined on 15/7/2014We celebrated a 70th Birthday dinner with friends, and the restaurant was so accommodating. The food is fantastic and such good value for money. The staff are efficient, friendly and always helpful - to the point where they all sang Happy Birthday when presenting the cake to our friend. It was magical! My favourite restaurant in Chelsea.Special Features:
- live2eatDined on 12/7/2014I booked a deal on opentable for two courses, a glass of wine and a coffee. While the service and food was lovely, I almost felt awkward being there with a voucher because a) the glass of wine wasn't offered to us, I had to remind them that we get a free glass of wine, and b) we saw other diners receive focaccia bread to enjoy with their meal and cookies at the end with the cheque, however, we did not receive either of those complementary items. I had gone to another restaurant with a similar deal and was treated like everyone else--no one would have known who was and wasn't using a voucher. I suggest this restaurant do the same.Special Features:
- Simply lovelylon35Dined on 12/7/2014Always incredibly fresh, flavourful Italian food that is almost without compare. Ingredient combinations are original and unexpected, but realised with subtlety. We've been going to Manicomio for lunches and dinners since they first opened, and there has never, ever been a lapse in the quality of the food or service. Go on a sunny day and enjoy one of the best alfresco dining experiences in London - great people watching via the Duke of York Square. It's the perfect venue for a girls' post-shopping lunch and glass of wine, lunch with the family (we now take our 1 year old daughter, and she could not be more welcomed), pre/post-theatre dinner (for the Royal Court), and an outdoor, romantic summer dinner with your other half. Simply lovely!Special Features:
- great lunch place in ChelseaLove2eatVIPDined on 27/6/2014We went there and had the lunch offer with 2 course menu. The options included met, fish and risotto and the starters had a great fish stew which was very tasty. We sat outside and the place is great for people watching, too. The service is attentive.Special Features:I would recommend this to a friend.
- La Dolce VitalyndaweaDined on 25/6/2014This is a fantastic restaurant - perfect for alfresco dining outside with a true Italian buzz and lots of people watching, and the perfect winter restaurant with its warm Tuscan feel inside. Superb wine list and the food outstanding, great location. Highly recommended.Special Features:
- Perfect RelaxingsmudgeDined on 22/6/2014Another excellent meal our request for an outside table was honoured and appreciated on such a beautiful Sunday. Perfect spot for people watching . Food was excellent as was the service. Slight mistake with the olives taken to the wrong table but not a major issue.Special Features:
- great spot!!!DiaPreDined on 21/6/2014Great spot in SW ! The food is always top quality and plenty to choose form. Very friendly and attentive service!Special Features:I would recommend this to a friend.
- Manicomio ChelseaLovestoeatoutDined on 18/6/2014We eat here regularly and the service is always excellent. The managers are charming, remembering names and always check up on the tables during the course of the evening. The food is good without being overly fussy, and is good value for money. The portions are not enormous which suits us, but may be a little small for those who like more food. The terrace outside is always fun, a great 'people spotting' venue, however, personally I find inside a little dark. I really like the Organic cow ricotta and zucchini agnolotti (v) with burnt butter and the fish is always perfectly cooked. The special menu is always varied and I would say that one could always find something to suit every palate. Menu not extensive. Wines are reasonably priced.Special Features:I would recommend this to a friend.
- The food is too blandmlGRnDined on 7/6/2014Nice ambience that's all I m going to say but the food is very bland
- Ambiance surpasses the foodWoodyDined on 23/5/2014Ambiance (inside and out) very, very nice. Excellent location in Duke Square, but the menu let it down a little. Limited choice and bit on the expensive side overall. Happy to pay for the quality of venue but food needs to be better. Wine wasn't cold enough but they did provide a lot of ice to put this right - wine should have been cold.Special Features:I would recommend this to a friend.
- Chelsea LunchbazelhadDined on 22/5/2014Delightful meal prior to visit to Chelsea Flower Show. Busy and efficient restaurant- lovely foodSpecial Features:I would recommend this to a friend.
- Highly recommended for Quick diningadorediningDined on 20/5/2014Had a swift lunch before the Chelsea Flower Show and it was superb.. courteous and lovely service.. wonderful food and really nice ambience to the whole occasion.. My friend was a vegetarian and they adapted a dish to ensure she was catered for specifically however she did say that there was plenty of choice already on the menu so she was extra happy with this additional service..Special Features:
- Foodie27VIPDined on 20/5/2014We had a very pleasant lunch(we had set menu which is good value). Good service , nice presentation. Try not to sit by the bar as you get all the noise of barman shaking ice for cocktails!!Special Features:
- Harry13HarryDined on 20/5/2014Second visit in two weeks. Very good food and excellent service. Friendly staff and no sense of being rushed despite Chelsea Flower show making it one of the busiest weeks of the year. Perfect for meeting friends for lunch. This restaurant deserves to do well.Special Features:I would recommend this to a friend.
- Pre Chelsea Lunchyelnats16Dined on 20/5/2014Just what we needed - was very busy which reflects in my assesments. Food was delicious - sourced from the Ginger Pig. For someone from Yorkshire it was expensive, £60 for 2 - but that is probably a reflection on London pricesSpecial Features:
- Outstanding servicenikkinoosDined on 17/5/2014I love this restaurant. The waiters are kind, courteous, friendly and efficient.I would recommend this to a friend.
- Excellent dinnerOpenTable Diner Since 2008Dined on 12/5/2014Superb food and excellent value on their fixed menu. A delightful experience in all.Special Features:I would recommend this to a friend.
- great location and always reliablelondonlucy123Dined on 12/5/2014I usually eat here with my mum as she comes in on the tube. manicomio always has good things on the menu (there is usually always a pasta I want) and I've never had a bad meal. I've been several times and each time we have a good lunch. The only slight downside is the service can be too slick! You do feel a little rushed - no sooner is the last mouthful in your mouth before the plate is cleared and you are being asked for dessert. I'd rather have service which is quick vs service which is too slow, so I must sound extra picky - however on the upside, if this is all I can criticise then it's no bad thing!Special Features:I would recommend this to a friend.
- BESTATFOODVIPDined on 8/5/2014Lunch at Manicomio in Chelsea was a delight. Great value with the current offer. Food & wine good & service very helpful & friendly.Special Features:I would recommend this to a friend.
- My foodie friendsnikkinoosDined on 7/5/2014I took two friends for lunch. They are both foodies and they absolutely loved Manicomio. The waiters were charming and couldn't have been more helpful. We choose to sit outside and they gave us four heaters. We were the only diners sitting outside as it was quite cold and also raining but they staff were really lovely.Special Features:I would recommend this to a friend.
- Good Food/Pushy WaiterAlraDined on 3/5/2014Two of us went Saturday night booking through Open Table offering a set menu-2 courses with a glass of wine and coffee for £22/3 courses for £26. The food was absolutely delicious. The manager offered us a glass of wine after we settled at our table which we declined until we made up our mind as to what we were eating. A waiter then came and offered us a bottle of wine at a discounted price, when we declined. He then recommended we have a glass of Gavi and we accepted a large glass. What we did not realise that this wine was not included on the set menu, which is fair enough but he did not mention it. He knew we were eating off the set menu. On receiving our bill it was £12 a glass! Lovely food though.I would recommend this to a friend.
- Languid lunch.Petrus1Dined on 3/5/2014Excellent food and service, portions not large, but the quality of the ingredients is superb and innovative. Staff knowledgable and friendly.Special Features:I would recommend this to a friend.
- Outside but warmLynneVIPDined on 27/4/2014You can sit outside people watching whilst keeping warm under their heaters. A great way to spend Sunday lunchtime.Special Features:
- The worst service I've ever hadAlezavariseVIPDined on 19/4/2014Bad attendant, expensive like Ducasse but with a 10% of his quality
- Service? AwfulOpenTable Diner Since 2014Dined on 16/4/2014Nice food but the service was awful, you need to get your act together, lovely food but overheated restaurant and appalling service.
- GreatDinerKkVIPDined on 10/4/2014We enjoyed eating here very much. Good food and good value. Would go back again for sure.Special Features:I would recommend this to a friend.
- Great to eat outside on aTooleyDined on 8/4/2014Great to eat outside on a Sunney day .great food .Special Features:
- Ate here before and it wastonyVIPDined on 2/4/2014Ate here before and it was excellent. Table booked for 2030 this time and did not have any food until well after 2100 and did not finish our second course until after 2200. I think it may just have been a bad night. I would try again.Special Features:I would recommend this to a friend.
- Italian food with a twistSinglePigeonDined on 24/3/2014This is a better than decent restauant with above average food. It lacks the individuality of the branch in the City but a more than satisfactory atmosphere all the same. The tables are not too close together which for me is always a plus. For a decent mid-price dinner or lunch with good service I would ceratinly recommend Manicomio.Special Features:I would recommend this to a friend.
- The BestaebwDined on 21/3/2014I have eaten here a number of times, it really is a fantastic restaurant. Every time I go the food is great and the service is smooth and efficient. I have eaten at most of the top Italian restaurants in London, but this place is by far my favourite. Don't miss out on the foccacia and the olive oil.Special Features:I would recommend this to a friend.
- Good but overly attentive serviceDeliciousDinnerDined on 19/3/2014Very lovely food and atmosphere but tables were far too close together so there was no room for the wine holder and much as the staff were attentive, we were barely able to take a sip of wine before it was topped up. Dishes were offered to be removed before we had finished eating because we were too busy chatting between mouthfuls.
- saraVIPDined on 9/3/2014The food was MUCH better than it used to be. Great service.
- Good food, great for al fresco luncy1234Dined on 7/3/2014A quick lunch at Manicomio with a friend was pleasant, and it was lovely to be able to sit outside in the sunshine over some wine and food. My salad was interesting and my friend's fish and the main looked even better.Special Features:


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Play time for my baby
By: That_BBW_Girl
Video Details
Date: 1 year ago
Runtime: 2:41
Views: 2,882
3 Comments
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1 year ago
Delicious! I can imagine your sexy fingers guiding my stiff cock to your wet hole!
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1 year ago
Great video, love how vocal you are
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I am desperate to please you orally.....
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