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Merritt MartinOh, you can damn well bet this is on the list.By now most of you dear readers are well aware of the Gawker-produced list of the 50 Worst States In America. Gawker placed their home base at 50, and the Lone Star State at 13. Sure sure, our placement could be worse, but instead of ... More >>
Since news about Texas food tends to find its way to my inbox, I know way more than I should about Texas Roadhouse happenings. I don't usually find too much in the Roadhouse oeuvre that's worth sharing, but I was oddly riveted by a recent announcement regarding the restaurant chain's partici ... More >>
Sam MertenFriedman campaigning at Urban Dog Coffee on Oak Lawn back in FebruarySo insists the Texas Jewboy and former gubernatorial candidate in a piece penned for Tina Brown's Daily Beast, the headline of which is "Why Democrats Should Blame Themselves for the Tea Party." Friedman, who lost to h ... More >>
DISD school board trustee Carla Ranger Took her a few days for her to respond, but, at last, Dallas Independent School District trustee Carla Ranger has posted a lengthy essay concerning the school board's Thursday-night vote to extend the trustees' terms from three to four years. Ranger, who's alre ... More >>
Lew Calver's "Hole in the Ground," his entry in the Bush Library design contest Last week, we made note of The Chronicle of Higher Education posting some 20 entries it received for its Design the Bush Library contest. Turns out, one of the entries comes from a Dallas resident -- so, please, go here ... More >>
Because Texas Observer managing editor David Pasztor asked so nicely -- in an e-mail that begins, "Yo, dipshit" -- we're going to toss out a recommendation that you head immediately to the Lakewood Theater to check out readings from the Texas Observer by Lou Dubose, Wade Goodwyn and Jake Bernstein, ... More >>
Plus: Winning is Fun; Ethan Makes a Funny
These films do ask, do tell
KLIF-AM 570's Tom Kamb Departs
Missing Molly, Discordant Sound, A Sorry Man
Pat Buchanan waves the bigot's banner in New Hampshire
Texas' former presidential candidate never learned the art of compromise
Television has replaced the family as the biggest influence in some kids' lives
Phil Gramm and the R's cozy up to the average working guy
Barbara Jordan, a woman of firsts, was faithful to the last
Bryant's announcement should give Gramm a real race
Striking machinists won't buckle under to greedy Boeing bosses
GOP budget is greatest-ever transfer of wealth from the Have-Nots to the Haves
Colin Powell's decision reveals distasteful state of American politics
Americans don't understand why Quebec wants to secede
Cap Cities/ABC decision to fire radio host Hightower was a big mistake
Clinton's Austin speech posed a clear-eyed counterpoint to the Million Man March
Shady goings-on in the fight over health care
We're about to get bit again by deregulation
Texas Lege folds to pressures of Republicans and lobbyists
Christian Coalition stumbles on its good intentions
The CIA should open its files on slain Guatemalan guerrilla Everardo
Republican freshmen fall behind their cheerless leader
Cincinnati stamps out sin--and civil rights, besides
'Tort reform' is a misleading euphemism--an excusefor insurance companies to gouge more
For women in the public eye, there's no end to the verbal abuse
It's scary, folks, but St. Pete's Dancing Marlin isn't a bad place to eat
Deadbeat-dad Newt Gingrich wants to slash program for disabled children
Indonesia is home to one of the world's worst ongoing environmental tragedies
Thoughts on GATT, retraining, corporate welfare, and Bosnia
New members of the Texas Lege promise to uphold the old seedy standards
Consider the sheer entertainment value of our new Republican leaders
In the GOP back East, even Lincoln would fit in

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Bret Michaels has suffered another medical scare.
The 51-year old rocker, who had a brain hemorrhage in 2010, collapsed on stage at the Palace Theatre in Manchester, New Hampshire last night.
A Type-1 diabetic, Michaels had performed three songs with an "extremely low" blood sugar, according to guitarist Pete Evick, who said paramedics rushed to the singer's aid and helped transport him to the hospital.
"Bret looked at me and looked like he was gonna die," the musician wrote in a text to Metal Sludge.


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Phantasy Star Online Dreamcast
- Release Date: Jan 29, 2001
- Summary: Pioneer 2 finally completed it's long voyage to the new home world. But as the ship entered orbit, an enormous explosion shook the entire planet, and all contact with the thousands of people already there was lost. Now, in the first worldwide online console RPG, players from around the globe must unite to discover what has happened. Phantasy Star Online continues in the tradition of one of the most popular series of all time, and becomes a revolutionary and truly global gaming experience in an online, persistent world.… Collapse
- Developer: Sonic Team
- Genre(s): Role-Playing
- Cheats: On GameFAQs
- More Details and Credits »
Score distribution:
Positive: 20 out of 21
Mixed: 1 out of 21
Negative: 0 out of 21
Explaining the genius and scarily addictive quality of Phantasy Star Online is tricky indeed, it is something that needs to be played and experienced.
As a single player game there is room for improvement but overall the stellar graphics, excellent sound and added touch of the online multiplayer ability make PSO a must have for any Dreamcast owner. The Joystick is way up.
Like the original "Diablo," the game offers an insidiously addictive style that you'll be hard pressed to pull yourself away from.
One billion points for single handily dragging online RPGs out of a mire of orcs, beards and dreadful graphics. It's repetitive and shallow (kind of) but it's also amazingly beautiful, addictive and - believe it or not - socially rewarding and instructive!
The graphics in Phantasy Star Online are excellent in all respects. Not only is the lighting superb, but the general design of the environments is also both visually appealing and extremely efficient.
It's straightforward, hack-n-slash combat online or off. But you must jump online, however, to get the full experience of what the Dreamcast is capable of doing.
Score distribution:
Positive: 6 out of 6
Mixed: 0 out of 6
Negative: 0 out of 6
BrianW.Jun 27, 2001This is the best RPG I have ever played. Making new characters and improving them. You can customize your character to all most every race on Earth. Even if you want him to look like a total idiot you can.… Expand
BobD.Jul 3, 2001This wonderfully thought out game brings to life the true aspects of how an online RPG really should be. One of the best I've played in a long time.… Expand
JeremyT.Jul 5, 2001Brilliant.
JubeiT.Jan 23, 2002I LOVE THIS GAME! So you ask then why did I give it a 9? because its got a terrible story just like every other action/adventure (since this no RPG it just RPG elements like most games do) but 3 words sum it all up: BUY THIS GAME!… Expand
Feb 18, 2014This game is truly mind blowing. I mean this game came out in 2001, graphics are good, first online console MMO, story amazing, atmosphere. I remember playing with my friend it was an adventure. It's repayable. The only bad thing is probably its sound quality. Maybe thats just for me.… Expand


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- freely available
- re-usable
Metabolites 2012, 2(2), 292-302; doi:10.3390/metabo2020292
Published: 23 March 2012
Abstract: AICAR (5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranosyl 5'-monophosphate) is a natural metabolic intermediate of purine biosynthesis that is present in all organisms. In yeast, AICAR plays important regulatory roles under physiological conditions, notably through its direct interactions with transcription factors. In humans, AICAR accumulates in several metabolic diseases, but its contribution to the symptoms has not yet been elucidated. Further, AICAR has highly promising properties which have been recently revealed. Indeed, it enhances endurance of sedentary mice. In addition, it has antiproliferative effects notably by specifically inducing apoptosis of aneuploid cells. Some of the effects of AICAR are due to its ability to stimulate the AMP-activated protein kinase but some others are not. It is consequently clear that AICAR affects multiple targets although only few of them have been identified so far. This review proposes an overview of the field and suggests future directions.
1. Introduction
AICAR (5-Aminoimidazole-4-carboxamide-1-β-D-ribofuranosyl 5'-monophosphate), also known as ZMP (the "Z" referring to imidaZole [1]), is an intermediate in the inosine monophosphate (IMP) conserved pathway which is responsible for de novo purine biosynthesis in all organisms. The recent attention paid to AICAR is testified by more than one thousand publications referenced in databases such as PubMed, 90% of which having been published during the last 10 years. This massive and sustained interest for this small molecule is due to its multiple biological effects, which will be presented in this review.
2. Metabolism of AICAR
AICAR is an intermediate metabolite in the purine de novo synthesis pathway (Figure 1), it is synthesized from succinyl-AICAR (SAICAR) by adenylosuccinate lyase (ASL), an enzyme inhibited by AICAR through a feedback regulation [2]. As a consequence, massive accumulation of AICAR is associated with SAICAR accumulation in micro-organisms such as yeast [3] and in a specific human pathology [4]. In the de novo purine synthesis pathway, AICAR is further metabolized to IMP by successive action of AICAR-Transformylase and IMP Cyclohydrolase, two enzymatic activities which are generally carried on a single protein named ATIC. In micro-organisms, AICAR is also synthesized as a by-product of the histidine biosynthesis pathway (Figure 1).
Under conditions where AICAR accumulates, riboside and triphosphate derivatives are often found in cellular extracts or body fluids. A patient lacking ATIC activity showed accumulation of large amounts of AICAR riboside (also known as acadesine or AICAr) in urines and mono- di- and tri-phosphate forms of AICAR in erythrocytes [4]. The enzyme(s) dephosphorylating AICAR monophosphate to its riboside form is not identified yet, but it is clear that adenosine kinase can reverse the reaction and phosphorylate AICAR riboside to the monophosphate form [5]. Synthesis of ZTP (triphosphate form of AICAR) was found to occur directly from AICAR through the catalytic action of PRPP-synthetase [6]. Consequently, ZDP (diphosphate form of AICAR) detected in erythrocytes is likely to result from ZTP degradation and to appear upon intracellular degradation or during metabolite extraction, rather than be a ZTP synthesis intermediate. In the early eighties, ZTP was proposed to be an "alarmone" signaling folate deficiency in Salmonella typhimurium [1] but a later study did not confirm such a role for ZTP in Escherichia coli [7].
3. Roles of Physiologically Produced AICAR and Accumulation in Metabolic Diseases
A physiological role for AICAR has been found in yeast cells where it stimulates the interaction between two pairs of transcription factors (Bas1-Pho2 and Pho4-Pho2), thereby resulting in the transcriptional activation of specific sets of genes [3,8]. Importantly, most of the AICAR-responsive genes also respond to extracellular adenine, their expression being low when adenine is abundant in the growth medium [3,9,10,11,12,13,14]. AICAR concentration is linked to exogenous adenine through feedback regulation of the first step of the purine de novo pathway. This feedback regulation is thought to be mediated by ATP and ADP [2]. Consistently, in adenine replete conditions, ADP and ATP concentrations are higher [12], while AICAR concentration decreases [15]. Finally, fusion chimera between AICAR-stimulated transcription factors resulted in an adenine-independent transcriptional activation of the target genes [3,16]. These results led to a model accounting for the complex regulatory effects of AICAR in yeast and their connection to purine precursor availability in the growth medium (Figure 2). Beside these physiological effects associated to moderate AICAR accumulation, massive accumulation of AICAR can also lead to detrimental effects in yeast. Intracellular accumulation of AICAR in the millimolar range provokes histidine auxotrophy and, when combined to the fau1 mutation affecting 5,10-methenyltetrahydrofolate synthetase, leads to methionine auxotrophy. Higher concentrations, up to 10-15 mM, result in growth arrest [15]. In yeast, physiological and detrimental effects of AICAR are only associated to its phophorylated form(s), since accumulation of the riboside form at the same concentration has no effects either on transcription, amino-acids prototrophy nor on cellular growth [15].
In mammalian cells it is not known whether endogenous AICAR plays regulatory roles. It is however striking that most purine metabolism-associated diseases result in AICAR accumulation in the patient cells [17]. The most dramatic accumulation of AICAR was observed in the erythrocytes of an ATIC-deficient patient and was associated to dysmorphic features, severe neurological defects, and congenital blindness [4]. At this point it is not clear whether some or all of these symptoms are the direct result of very high AICAR concentrations or whether they are due to the increase of AICAR derivatives and/or to the severe ATP depletion associated with AICAR massive accumulation [4]. The consequences of AICAR accumulation in other purine metabolism-associated diseases is not established, but AICAR was proposed as the possible toxic metabolite in Lesch-Nyhan disease resulting from impaired hypoxanthine-guanine phosphoribosyl transferase [18].
4. AICAR, a Potent Activator of AMP-Activated Protein Kinase
In the early 90s, AICAR in its monophosphate form was found to activate the human AMP-activated protein kinase (AMPK) activity in vitro [20]. The AICAR riboside precursor was then used to activate AMPK in isolated rat adipocytes [21]. Since then, AICAR has been used in hundreds of studies as an inducer of AMPK activity. A major advantage of AICAR compared to other AMPK-inducers is that AICAR addition at low concentration (< 500 µM) does not affect AMP, ADP or ATP levels [22]. However, more recently, effects of AICAR on ATP concentration were reported in rat hepatocytes [23,24]. This observation combined with the multiple AMPK-independent effects reported for AICAR (see below) should inspire cautious interpretation of the results (as discussed in [25]).
AICAR was found to directly interact with the gamma-subunit of AMPK. This interaction induces a conformational change and favors phosphorylation of the catalytic alpha subunit, which in turn becomes more active. Structural analysis of the AMPK-AICAR complex suggests that activation of this protein kinase by AICAR mimics activation by AMP [26]. Hence, the effect of AICAR on AMPK is presumed to be direct.
AICAR monophosphate is provided to the cells as a riboside precursor, which is taken up by adenosine transporter(s) [27]. In many studies, the authors use an inhibitor of adenosine kinase to show that AICAR monophosphate, and not its riboside precursor, is the active molecule (Figure 3) [28]. Among the effects attributed to AICAR monophosphate, many are AMPK-dependent as shown by si- or sh-RNA gene silencing of the gamma-subunits (see Figure 3). For instance the potent effect of AICAR on induction of apoptosis in aneuploid cells was abolished by shRNA on AMPK, however it was poorly mimicked by other AMPK inducers such as metformin or 2-deoxyglucose [29]. This example illustrates the complexity of AICAR effects and calls attention to the fact that a careful analysis is required to establish whether an AICAR effect is fully AMPK-dependent or not.
5. AMPK-Independent Effects of AICAR: Other Protein Targets
It should be stressed that there is a growing number of examples where AICAR effects are totally or partially independent of AMPK (Figure 3) [37,38,39,40]. It appears more and more evident that AICAR is a multi-target molecule resulting in complex and combined effects, in line with the paradigm of "network pharmacology" recently proposed by A. Hopkins [41]. For such highly integrated effects, it is critical to apprehend the complexity of the drug effects by identifying its targets. This quest is complex because it requires to identify drug-interacting proteins and establish their role in the drug action in vivo.
The use of an AICAR-resin has allowed validating two yeast transcription factors as AICAR-binders [3]. More recently, affinity chromatography coupled to mass spectrometry allowed us to perform a large-scale identification of yeast and mouse AICAR-binders, many of which being conserved through species (our unpublished results).
The next step is to validate the binders as true AICAR targets in vivo. Interestingly, it was recently found that the yeast AMPK (Snf1) is activated by ADP but not by AMP [42], thereby accounting for the fact that AICAR apparently does not activate the yeast AMPK, as presumed from the transcriptome signature [3]. Yeast is therefore an appealing simple eukaryotic model to study AMPK-independent AICAR effects.
Aside from AMPK, AICAR modulates several enzymes such as glucokinase [43] or glycogen phosphorylase [44]. In a few cases, direct binding of AICAR to specific proteins has been reported, including phosphofructokinase (PFK) and fructose-1,6-biphosphatase (F1,6-BPase) which are inhibited in vitro by AICAR [45,46]. AICAR interaction with Hsp90 was also demonstrated and many client proteins of Hsp90 were found destabilized in vivo in the presence of AICAR [47]. Both PFK and Hsp90 contribute to important functions for tumor growth and could thus be involved in the anti-proliferative effects of AICAR, which was reported for several tumor cell lines (such as PC-3, MCF-7,C6 glioma, U87MG, K-562 and CEM) [48]. It is noteworthy that, while AICAR replaces AMP in AMPK [26], it competes with ATP in Hsp90 [47]. It will be interesting to determine whether all AICAR targets are nucleotide-binding proteins.
6. Effects of AICAR on Whole Organisms
There are few studies showing effects of AICAR on whole organisms and in most cases the protein effectors are not clearly identified, although AICAR was chosen in these studies for its AMPK-activating properties.
AICAR feeding of Caenorhabditis elegans resulted in decreased fat storage as would be predicted when AMPK is activated [49]. Drosphila melanogaster fed with AICAR were more resistant to anoxia/re-oxygenation injuries [50]. AICAR has been found to reduce myocardial ischemic injury in several models (rat, mice, rabbit, dog…) [51] and in humans [52]. Injection of AICAR to mice resulted in a hypoglycemic effect [53]. Strikingly, sedentary mice fed with AICAR showed increased endurance [54]. AICAR was renamed "the exercise pill" and subsequently suspected of human misusage as a doping agent. AICAR is not currently approved by FDA and has only been used in a very few investigations in humans [55,56,57].
7. Conclusion
AICAR is a highly promising pharmacophore showing various effects on multiple functions. In the future, AICAR or derivatives could represent key molecules for several diseases including heat induced sudden death, cytochrome c-oxidase deficiencies, cancer and other pathologies associated with muscle wasting. The systematic identification of AICAR targets is now required to understand the complex consequences resulting, most probably, from synthetic effects on several proteins. Importantly, AICAR has both activating and inhibiting effects and hence, determining the way AICAR affects each target will require individual characterization. This time consuming process will hopefully be made easier by the use of model organisms such as yeast or nematode.
We apologize to authors whose work has not been cited here owing to space limitations. We thank Eric Chevet for helpful comments on the manuscript. This work was supported by Association Française contre les Myopathies.
Conflict of Interest
The authors declare no conflict of interest
References and Notes
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- Corton, J.M.; Gillespie, J.G.; Hawley, S.A.; Hardie, D.G. 5-aminoimidazole-4-carboxamide ribonucleoside. A specific method for activating AMP-activated protein kinase in intact cells? Eur. J. Biochem. 1995, 229, 558–565, doi:10.1111/j.1432-1033.1995.tb20498.x.
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- Viollet, B.; Guigas, B.; Leclerc, J.; Hebrard, S.; Lantier, L.; Mounier, R.; Andreelli, F.; Foretz, M. AMP-activated protein kinase in the regulation of hepatic energy metabolism: from physiology to therapeutic perspectives. Acta. Physiol. (Oxf.) 2009, 196, 81–98, doi:10.1111/j.1748-1716.2009.01970.x.
- Day, P.; Sharff, A.; Parra, L.; Cleasby, A.; Williams, M.; Horer, S.; Nar, H.; Redemann, N.; Tickle, I.; Yon, J. Structure of a CBS-domain pair from the regulatory gamma1 subunit of human AMPK in complex with AMP and ZMP. Acta. Crystallog.r D. Biol. Crystallogr. 2007, 63, 587–596.
- Fryer, L.G.; Parbu-Patel, A.; Carling, D. Protein kinase inhibitors block the stimulation of the AMP-activated protein kinase by 5-amino-4-imidazolecarboxamide riboside. FEBS Lett. 2002, 531, 189–192, doi:10.1016/S0014-5793(02)03501-9.
- Ugarkar, B.G.; DaRe, J.M.; Kopcho, J.J.; Browne, C.E., 3rd; Schanzer, J.M.; Wiesner, J.B.; Erion, M.D. Adenosine kinase inhibitors. 1. Synthesis, enzyme inhibition, and antiseizure activity of 5-iodotubercidin analogues. J. Med. Chem. 2000, 43, 2883–2893.
- Tang, Y.C.; Williams, B.R.; Siegel, J.J.; Amon, A. Identification of aneuploidy-selective antiproliferation compounds. Cell 2011, 144, 499–512, doi:10.1016/j.cell.2011.01.017.
- Mihaylova, M.M.; Shaw, R.J. The AMPK signalling pathway coordinates cell growth, autophagy and metabolism. Nat. Cell. Biol. 2011, 13, 1016–1023, doi:10.1038/ncb2329.
- Hardie, D.G. AMP-activated protein kinase: an energy sensor that regulates all aspects of cell function. Genes Dev. 2011, 25, 1895–1908, doi:10.1101/gad.17420111.
- Wong, A.K.; Howie, J.; Petrie, J.R.; Lang, C.C. AMP-activated protein kinase pathway: a potential therapeutic target in cardiometabolic disease. Clin. Sci. (Lond.) 2009, 116, 607–620, doi:10.1042/CS20080066.
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- Lanner, J.T.; Georgiou, D.K.; Dagnino-Acosta, A.; Ainbinder, A.; Cheng, Q.; Joshi, A.D.; Chen, Z.; Yarotskyy, V.; Oakes, J.M.; Lee, C.S.; Monroe, T.O.; Santillan, A.; Dong, K.; Goodyear, L.; Ismailov, II; Rodney, G.G.; Dirksen, R.T.; Hamilton, S.L. AICAR prevents heat-induced sudden death in RyR1 mutant mice independent of AMPK activation. Nat. Med. 2012, 18, 244–251.
- Isebaert, S.F.; Swinnen, J.V.; McBride, W.H.; Begg, A.C.; Haustermans, K.M. 5-aminoimidazole-4-carboxamide riboside enhances effect of ionizing radiation in PC3 prostate cancer cells. Int. J. Radiat. Oncol. Biol. Phys. 2011, 81, 1515–1523.
- Robert, G.; Ben Sahra, I.; Puissant, A.; Colosetti, P.; Belhacene, N.; Gounon, P.; Hofman, P.; Bost, F.; Cassuto, J.P.; Auberger, P. Acadesine kills chronic myelogenous leukemia (CML) cells through PKC-dependent induction of autophagic cell death. PLoS One 2009, 4, e7889.
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- Jacobs, R.L.; Lingrell, S.; Dyck, J.R.; Vance, D.E. Inhibition of hepatic phosphatidylcholine synthesis by 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside is independent of AMP-activated protein kinase activation. J. Biol. Chem. 2007, 282, 4516–4523.
- Kuo, C.L.; Ho, F.M.; Chang, M.Y.; Prakash, E.; Lin, W.W. Inhibition of lipopolysaccharide-induced inducible nitric oxide synthase and cyclooxygenase-2 gene expression by 5-aminoimidazole-4-carboxamide riboside is independent of AMP-activated protein kinase. J. Cell Biochem. 2008, 103, 931–940, doi:10.1002/jcb.21466.
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- Hopkins, A.L. Network pharmacology: the next paradigm in drug discovery. Nat. Chem. Biol. 2008, 4, 682–690, doi:10.1038/nchembio.118.
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- Javaux, F.; Vincent, M.F.; Wagner, D.R.; van den Berghe, G. Cell-type specificity of inhibition of glycolysis by 5-amino-4-imidazolecarboxamide riboside. Lack of effect in rabbit cardiomyocytes and human erythrocytes, and inhibition in FTO-2B rat hepatoma cells. Biochem. J. 1995, 305 ( Pt 3), 913–919.
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- Rattan, R.; Giri, S.; Singh, A.K.; Singh, I. 5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside inhibits cancer cell proliferation in vitro and in vivo via AMP-activated protein kinase. J. Biol. Chem. 2005, 280, 39582–39593.
- Lemieux, G.A.; Liu, J.; Mayer, N.; Bainton, R.J.; Ashrafi, K.; Werb, Z. A whole-organism screen identifies new regulators of fat storage. Nat. Chem. Biol. 2011, 7, 206–213.
- Vigne, P.; Tauc, M.; Frelin, C. Strong dietary restrictions protect Drosophila against anoxia/reoxygenation injuries. PLoS One 2009, 4, e5422.
- Mullane, K. Acadesine: the prototype adenosine regulating agent for reducing myocardial ischaemic injury. Cardiovasc. Res. 1993, 27, 43–47, doi:10.1093/cvr/27.1.43.
- Leung, J.M.; Stanley, T., 3rd; Mathew, J.; Curling, P.; Barash, P.; Salmenpera, M.; Reves, J.G.; Hollenberg, M.; Mangano, D.T. An initial multicenter, randomized controlled trial on the safety and efficacy of acadesine in patients undergoing coronary artery bypass graft surgery. SPI Research Group. Anesth. Analg. 1994, 78, 420–434.
- Vincent, M.F.; Erion, M.D.; Gruber, H.E.; Van den Berghe, G. Hypoglycaemic effect of AICAriboside in mice. Diabetologia 1996, 39, 1148–1155, doi:10.1007/BF02658500.
- Narkar, V.A.; Downes, M.; Yu, R.T.; Embler, E.; Wang, Y.X.; Banayo, E.; Mihaylova, M.M.; Nelson, M.C.; Zou, Y.; Juguilon, H.; Kang, H.; Shaw, R.J.; Evans, R.M. AMPK and PPARdelta agonists are exercise mimetics. Cell 2008, 134, 405–415.
- Bosselaar, M.; Smits, P.; van Loon, L.J.; Tack, C.J. Intravenous AICAR during hyperinsulinemia induces systemic hemodynamic changes but has no local metabolic effect. J. Clin. Pharmacol. 2011, 51, 1449–1458, doi:10.1177/0091270010382912.
- Babraj, J.A.; Mustard, K.; Sutherland, C.; Towler, M.C.; Chen, S.; Smith, K.; Green, K.; Leese, G.; Hardie, D.G.; Rennie, M.J.; Cuthbertson, D.J. Blunting of AICAR-induced human skeletal muscle glucose uptake in type 2 diabetes is dependent on age rather than diabetic status. Am. J. Physiol. Endocrinol. Metab. 2009, 296, E1042–1048.
- Cuthbertson, D.J.; Babraj, J.A.; Mustard, K.J.; Towler, M.C.; Green, K.A.; Wackerhage, H.; Leese, G.P.; Baar, K.; Thomason-Hughes, M.; Sutherland, C.; Hardie, D.G.; Rennie, M.J. 5-aminoimidazole-4-carboxamide 1-beta-D-ribofuranoside acutely stimulates skeletal muscle 2-deoxyglucose uptake in healthy men. Diabetes 2007, 56, 2078–2084.
© 2012 by the authors; licensee MDPI, Basel, Switzerland. This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).


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It's been a record-setting year for automakers, but not in a good way.
What exclusions apply to employees who are detained for medical reasons?
A common driving maneuver can be a risky move.
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What exclusions apply to employees who are detained for medical reasons?


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Jes Hathaway is the editor in chief of National Fisherman magazine and NationalFisherman.com.
Thursday, 19 January 2012
The big news out of Alaska this week is not snow but another perennial favorite: salmon.
The forecast is good for the Copper River, yes. But even more awe-inspiring is the decision on the part of the state's salmon processors to drop their financial support of the Marine Stewardship Council's sustainability certification.
The MSC has been at the forefront of eco-labeling and has led the charge to ease marketing and purchasing conundrums that developed as consumers were encouraged to ask whether the fish they were buying was the product of a sustainable fishery.
I can't say enough times that American seafood is sustainably managed. It is hands down the easiest choice for consumers who want to buy only "secure" sources of food.
Whether a private advocacy group puts a fishery on a brightly colored list has no bearing on how that species is being managed in this country (and it ought not). Our management system responds to data and is gradually being exposed to more cooperative research gleaned by scientists and fishermen working together.
I don't believe there is any likelihood that we will catch the last fish of any species. Mother Nature is smarter than we are. But I do know that if we allow fishing to become too efficient, we will do our best to bring that fishery back to a healthy population before establishing it as a viable commercial target again.
What people don't understand when they read "overfished" on a list is that the designation does not mean the species is on the brink of total collapse or at risk of disappearing altogether. It may simply mean that it was harvested at a rate higher than it was replenishing itself.
Of course, that's assuming fishing is the primary problem in the decline of a species. In many cases, it is not. Unfortunately, fishermen have little say over waterfront development, pollution, climate change or natural shifts in species habitats. They pay the price, nevertheless.
But maybe, just maybe, the U.S. fishing industry is on its way to having a say in how it is perceived. Kudos to Alaska's salmon pioneers. First for recognizing the benefits of eco-labeling and now for taking the next step in the wild beyond.
National Fisherman Live: 11/06/14
In this episode:
NOAA report touts 2013 landings, value increases
Panama fines GM salmon company Aquabounty
Gulf council passes Reef Fish Amendment 40
Maine elver quota cut by 2,000 pounds
Offshore mussel farm would be East Coast's first


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November 26, 2014
Retail sales show slight increase. The Nebraska Department of Revenue's Net Taxable Sales Report, comparing December 2011 to December 2010, shows Cass County with a 0.4% sales increase to $9,795,177. In the Plattsmouth city limits, December sales were up 3.8% to $4,752,897.
The Cassgram reports the November '11 report had Cass County with a 0.5% sales increase and Plattsmouth with a 0.8% increase from a year earlier.
Statewide, December 2011 taxable sales were 6.7% higher than in 2010.
The December report for neighboring counties: Otoe [+3.0%], Lancaster [+4.7%], Saunders [+3.4%] and Sarpy [+4.5%].
Nearby cities: Ashland [-1.9%], Bellevue [+4.7%], Nebraska City [+5.3%], Papillion [+1.1%] and Syracuse [-2.7%].
---The NDR's December Net Taxable Motor Vehicle Sales Report said Cass County recorded a 4.9% decrease when compared to the same month in 2010. Taxable motor vehicle sales totaled $3,872,273.
The statewide vehicle sales report showed an 8.1% increase when compared with December of the previous year.
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A community celebration of the arts on New Year's Eve First Night is Monterey's most exciting, imaginative and uplifting cultural event Our theme for First Night Monterey 2015 is "SeaChanges, the Seaquel." Explore the website beginning in October for overview of program, tickets information and sales. Download the complete program guide in December. Plan your night ahead by reviewing program and performers - it's a big night!
Wednesday, December 31, 2014 from 3 PM through Midnight
Historic Downtown Monterey - Over 22 performance sites, most venues are indoors. First Night Monterey goes on "Rain or Shine"! 85% SITES INDOORS! Buy buttons online now and at stores in December!
Your Purchase Directly Supports the Artist Fees.
Save $ by buying early! Admission Button Prices are:
$15 through December 6, 2014
$20 starting December 7, 2014 through December 30th
$24 December 31, 2014 (Day of Celebration), available at Event .
$10 through December 6, 2014
$12 starting December 7, 2014 through December 30th
$15 December 31, 2014 (Day of Celebration), available at Event
Buttons on sale at many local stores in Monterey County: Safeway Stores- all Monterey County Stores, Nob Hill Stores in Monterey & Salinas, Walgreens in Monterey & Seaside, 7-Eleven Stores in Monterey and Del Rey Oaks, Monterey Sports Center; or buy buttons online! Discounted Family Pack only available online through December 28, 2014.
Pick up buttons purchased on-line Dec 30-31st at our FNM Conference Center Will-Call Site
A community celebration of the arts, FNM is an affordable,
alcohol-free family celebration. A creation of activities, colors, lights,
musical entertainment and performances unfolds on New Year's Eve in Historic
Downtown Monterey for First Night Monterey as we dance, play, act, perform,
create and sing our way into 2015!
SeaChanges, the Seaquel! presents the majesty of the ocean and the issues of pollution through artwork completed this past year by youth and community members. The resolution room- challenging all of us to see the change we can make in our individual lives to "Sea" Changes!
We invite you to a very special party as we transform the streetscapes, buildings, theaters, churches and concert halls throughout Historic Downtown Monterey into a fun, informative and unique way for the community to experience multiple forms of art on an evening where we celebrate our uniqueness, our commonality and the coming of the New Year!
Activities begin at 3:00PM with the Opening Ceremony staged on Colton Lawn stage on Pacific Street. Kids Night Out! begins at 3:30PM with interactive art activities: face painting, henna tattoo artists, puppet art theater, folk music and magic show will entertain children of all ages. Join us for the Twilight Procession at 5:30 as we process down Alvarado Street. Commit your New Year's resolution at the interactive Resolution Sculpture. Performances range from Classical to Hip Hop, Jazz to Reggae, Dance Venues to the Written Word and a whole lot of art!
Grand Finale starts at 11:15. Check program and website for complete details.
There are many hotels to choose from right in Historic Monterey, some offer ticket packages; watch for information. First Night Monterey has a large and varied selection of food and beverage booths for your enjoyment. The Monterey Peninsula has excellent restaurants of every conceivable type; far too many to be listed here. For listings and reviews, go to www.monterey.com. We are located in historic downtown Monterey.


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Posts by jubtastic1
965 posts • joined 11 May 2006
Ultra-cheap HP TouchPads to hit UK at 6pm
£89 is cheaper than a kindle, it may not be getting any updates but for what it does out of the box it's a steal at that price.
AutoCAD LT arrives on the Mac
App store licencing
Covers 5 installs if memory serves, so it's just $180 per workstation, that's a massive discount that some clients of mine will be pleased to hear about.
10-year old hacker finds flaw in mobile games
Changing the clock is hacking now? Really?
Apple, Walmart, and you: Making money in mobile
"an app that allows me to start reading a story about how Arsenal has failed to sign yet another player, for example, should continue with me once I shut off my smartphone and open my tablet"
That would be iCloud then, of course it will take a while for devs to add the API to their apps but as you point out it will make for a killer feature, so I'd expect takeup to be swift, and as a bonus it's from that IT company you love to stalk about.
LOHAN spaceplane project starting to shape up nicely
You don't need a doughnut
Three balloons will form a hole at the centre as they firm up at altitude, a small hole granted but possibly big enough to shoot LOHAN through.
Game graphics could be 100,000 times better
I heard the word procedural mentioned
Which generally means you don't bother creating a 1:1 "map" of the environment but instead describe sections and let the graphics engine create the ity bity details on the fly.
This probably also explains the macro level similarities and minecraft like appearance. I wouldn't read too much into that, as the guy said, they're programmers not artists and the purpose of the demo was to illustrate the levels of microscopic detail. I'd bet money that every one of the very similar looking macro blocks was in fact unique.
That's Amazing!
If they can do physics on the atoms it's more like a simulation than a game engine, Lloyd Grossman was a nice touch as well.
Apple iCloud pricing revealed
Has anyone mentioned VAT yet?
Anyone... Bueller?
iPhone 5 now set for October launch
Cloud implementations
In previous efforts Apple attempted to put the users computers at the top of the tree with the cloud underneath them, this approach turned out to be fragile, iCloud puts itself at the top in a similar manner to competing sync engines so I'd expect a similar level of reliability between services, which is to say, they will all mostly work for most people.
AFAICT Google's cloud is basically an online filesystem, whereas Apple has gone for Application data Syncing, no idea what MS will do, probably both, I'd predict Googles approach being popular with techs, and Apples with users.
Just from my perspective here in the UK I still think it's a bit early for all this, that wireless networking lacks bandwidth and reliability and simply isn't ubiquitous enough for cloud services to replace local storage, I suspect a few early adopters will get properly burned, I suppose we have to start somewhere though.
Intel: Apple has online app sales exactly backwards
Sounds reasonable
Until you consider that the "we sell everything" approach of Amazon and eBay are the success stories of online shopping.
I suspect the reasons for this are twofold, firstly punters recognise the shop and know it's legit and secondly, because they sell everything.
Note to Apple: Be more like Microsoft
Right off the money as usual Matt
Are you suggesting Apple should get out of the hugely profitable hardware business and instead licence their OS to 3rd parties so that others may enjoy those margins or that we should suspend belief for the purposes of your article?
Just a tip, but if you should ever meet Steve Jobs in the flesh, remember not to cross your reality distortion fields.
Grassroots Brit project plans .app top-level domain bid
Call me a grumpy old man...
But no good will come of these newfangled TLD's, .app, .doc, .jpg, .etc
I can see misery looming ahead for the easily fooled masses and excited hand rubbing from the malware industry.
Kit steals Mac login passwords through FireWire port
If you've got automatic login switched on then you're not really going to be worried about a FireWire hack.
Interesting that sleeping lions with FDE can be awoken by this though, that sounds like a hole that needs plugging, <tinfoil hat> or maybe, it's supposed to do that </tinfoil hat>
Apple Mac OS X 10.7 Lion Part Two
Don't do this at home kids
There's a reason hardly anyone knows about it, Apple has purposefully made this hard to do/find out about because sooner or later you will lose data moving files, eg Finder lock up mid move or a disk issue. Moves are not transactional, interruptions will result in data loss.
Mega-colossal space raincloud found at moist black hole
Seems to me
That if you took 140 trillion oceans worth of water vapour, bombarded it with radiation and assorted space debris while stirring it for billions of years there would likely be a whole ecosystem of tasty lifeforms living in it by now.
Hello space things, pleased to meat you.
Adobe releases lengthy list of Apple Lion woes
Re: Wouldn't it be nice
If Adobe used standard OS windows and controls etc like *every* single other mac app on the platform so these problems, which are so common there's a website dedicated to pointing them out, didn't occur in the first place.
Fixing this is non trivial, seeing as it involves rebuilding the entire UI of the CS Suite, but then rolling their own UI was Adobe's choice, as was sitting on a Carbon codebase for a decade after it was depreciated. Numpties.
To the point, wouldn't it be nice if Adobe hired some engineers that can code worth a damn.
Euro beaks to rule if TVCatchup.com is legal
Awesome service
Net result of this being taken offline will be a reduction in the amount of TV watched in our house.
Message to the TV companies:
1) This service increases the exposure of shows, many of which have been added to normal TV viewing as a result of having been seen first on TV Catchup.
2) Negotiate with the service admins for viewing statistics, in show advertising is hitting extra eyeballs as a result of this and similar services, we have way more PC monitors than TV's in our house, dont focus on turning the Monitors off, make them count instead, more viewers means higher advertising rates.
3) Dumb TV's are on the way out, viewers want TV online, and they want it to be as easy as a TV, no one wants to have to load up a dozen websites to see what's playing on different channels.
4) You might wonder how a tiny outfit like this manages to stream at higher quality and greater reliability than your own in house efforts which have sucked up millions of pounds, maybe you could learn something from these guys.
Data Robotics gives up and changes name to Drobo
Not the same thing
QNAP does proper old fashioned RAID, striping across drives or mirroring, expansion involves rebuilding a drive from parity, basically an exact copy of the previous drive on a larger disk, repeat for all drives then enable the extra storage space. Performance is notably better if all the drives are of the same model.
Drobo does block level mirroring across whatever drives it decides are best suited for the data, if you drop a drive and replace it with another of different capacity, you'll end up with different blocks written to it than the original, essentially, what drobo does is ensure all data is on the array twice, it doesn't matter what type or size the drives are because they don't need to be in sync to read data off, drobo just reads from the most convenient drive.
That's the theory, and technically it works well, you can mix and match any old drives in there and expanding the array requires *nothing* more than popping a drive out and sliding a bigger one in, in practice however, throughput steadily slows down until it's unbearable to work with and starts causing timing issues with some applications, the only fix I've found is to clone the entire array, wipe it and then copy everything back, this will need repeating every x months, depending on the data and churn rate.
Fine for backup, no good for live storage.
Nice name
And Drobo is a cool concept, shame the IO performance degrades so quickly.
Not sure if it's fragmentation or index bloat but throughput has dropped by a factor of ten over the course of a year.
Asteroid hunter achieves Vesta orbit
What's the point in sending astronauts to a far flung rock, Wouldn't a robot be just as useful? Genuine question, seems a bloody long and dangerous journey just to look at a proto meteorite in it's natural habitat.
W3C moves to snuff Apple web patents
I'll bite.
It's a stupid patent, there seems to be plenty of prior art, but the USPO will probably grant it anyway because they seem intent on fucking up the US economy. Given this reality, I can't blame Apple or anyone else, for attempting to grab as much stuff as they can since what they don't grab they'll be defending themselves against in the EDC of Texas.
Additionally, it shouldn't be in the HTML spec, which is supposed to be about defining HTML elements, their behaviour and rendering. A mechanism for monitoring and reporting on browser activity is clearly well outside of the box model.
So plenty of stupid to go round, all thanks to the Patent Office.
Google top brass (and Zuck) hit Google+ privacy button
Unbelievably I did read the article, and the comments
And I totally understand that having your profile deleted doesn't mean your Email etc gets deleted.
Yet it seems clear that google+ requires a profile to work and that said profile has to be public, hence my sarcasm.
In case that's too hard for you to understand, I'm pointing out the blatant hypocrisy.of requiring users google+ profiles be public under the pain of deletion while Google top brass sets theirs to private, YFM.
I'm confused
Wasn't it just days ago they said that private profiles would be deleted?
Cleaning up the Bitcoin act
Couple* of thoughts
Don't trade with existing currencies, let it grow at it's own pace and you can forget about currency speculators who are IMHO complete bottom feeders.
Short selling is and will always be a crock of shit.
You need a bank, somewhere secure to store coins which can handle reversible transactions to prevent fraud/theft, yet issue coins for anonymous transfers if required. Home computers are a stupid place to store untraceable currency.
* modern interpretation of a 'couple' essentially meaning a random number, although staff in fast food resurants will interpret a request for 'a couple of sugars' as a 'handful'.
Entering a storage jail
It's easier than that
Just drag the track(s) from iTunes onto your email program to create a blank message with the files attached.
Makes you wonder if the author has actually installed iTunes, or bought any music from Apple or Amazon.
Oracle wants seal busted on HP's Itanium suit
Given that Oracle now employ HP's ex CEO
And Larry & Mark have been buds for some time, I'd say it's a fair bet that Itanium is getting dumped as alleged, that HP have documents to that effect, and that Oracle sees no downside in prematurely killing off a hardware partner now they have their own hardware to shift.
I would guess HP will attempt to tie all this up in court for a few years while they migrate their platform, doubt that will work out well for them though.
Moles say Mac OS X Lion to bound in next week
POS materials
Is all iPads in web kiosk mode, so I'd imagine it will take a blink of an eye to update.
Shipping, installing and drugging the promotional lion cubs that will be wandering about the store on launch day is likely to be a bigger deal.
Google: Go public on Profiles or we'll delete you
That's exacty what they want you to do
As far as they're concerned youre basically deadweight, sucking the bandwidth and cycles away from normal users that don't run adblock, have nice easy to target profiles and click on the money links every now and again.
Bug-Byte Manic Miner
Loading screen made me grin
The first few arrrgh-peeps, building anticipation for the game code's audio assault. Think I'm going to have to rip that for an alarm sound.
Behind Microsoft's $15 Samsung Android royalty claim
You don't get to see the cards for free.
Reprehensible? Yeah, but they'd be fools not to.
Coder cracks iPad 2 jailbreak block
Seems a waste
I get that there's something of a race to be the first to crack it but IOS5 is round the corner, most users are going to want to upgrade to that and it's hard to imagine Apple isn't going to plug an exploit that gives a website root access just by visiting. Should have saved this till after the update.
Ofcom maps state of UK broadband
Re: This amuses/depresses me
"My provider (Talk Talk) fails"
Popular FTP package download tarball poisoned
Hypothetically speaking
If say you had (by fair means or foul), root access to a popular FTP server, and you noticed from the logs that a lot of interesting users were using outdated versions of vsftpd, and you had a way of notifying those users to update, in the welcome message for example, then a headless hack like this takes on a whole new aspect.
Simply assuming that someone would go to all the trouble of poisoning a source depository just for the lols is a bit unimaginative.
I would be looking for the FTP servers that respond with :) in their handshakes personally, that might give us a clue as to what's going on.
Boffins fix dead satellite using 'dirty hack' in space
SAMBA cluster fucked
Power cycle hack makes it all better.
#alt heading
'Lion' Apple Mac OS X 10.7: Sneak Preview
@a bit confused about resume
They already do hibernate, including support for power outage, resume is more akin to the firefox feature which reopens all your tabs when you relaunch it but it's system wide and works across reboots.
Apple's long divorce from Samsung near final
There's more than just a CPU in a iPhone
I suspect Samsung makes quite a bit more selling NAND flash to Apple than they do knocking out ARM chips.
Travelodge still doesn't know who hacked it
OMG we've been haxxord!!1!
Funny how after years of denials, all of a sudden it's ok to admit you've been hacked, it's the new dog ate my homework excuse for corporate incompetence.
Apple Snow Leopard update sets stage for Lion
Yes, keep doing that
When it no longer boots because the filesystem is corrupt someone like me can charge you for fixing it :)
The time out is a safeguard, it's designed to allow you to intervene if an app can't quit, maybe because there are unsaved changes but in my experience it's usually because 10+ apps are all trying to quit at the same time and the disk can't respond quickly enough.
Quit apps manually (cmd+tab+q, q, q etc), or get a faster disk (like an SSD), or be prepared for when it inevitably fails from the forced power outages.
DRM-free music dream haunts Apple's app-store lock-in
Notice the author
It's basically the same as all his other articles which amount to "why isn't everything open source and free already?"
Is mp4, it's exactly as proprietary as mp3 and not surprisingly, owned by the same company.
There are very few devices that can't play mp4, it's baked into most hardware decoding chips.
Just a heads up in case you weren't aware.
Apple's next iPhone planned for September, says report
You don't need a crystal ball
To predict the next iPhone will have better cameras and the CPU from the iPad, that's exactly what they did last year.
A new case design, perhaps with a different antenna layout? That would be unexpected Easy NFC payments would be cool, Bigger edge to edge screen?
Got a website? Pay attention, Cookie Law will come
This is of course, utterly daft
We already had that, back in the early days of the web it was common to see sites pop up alerts asking for permission, it was terrible UX and broke functionality when users clicked no.
Perhaps the EU should mandate marquue's and flashing text be mandatory on every page to complete this trip down memory lane?
Video vigilantes in trouble again
That looks an awfully lot like me, I'll have to show that to the missis later.
Earth may be headed into a mini Ice Age within a decade
Frozen Thames
If the price of pointing and laughing at GW advocates is that my twilight years are so cold the bloody Thames freezes over then it's not worth it.
Breaking wave 'big as the USA' spied on Sun's surface
Means our surfer will weigh in at about 4.5 Mini coopers, quite the handicap for even the most adept of plasma surfers.
Russian computer programmer buries himself alive
Awkward phone call
Hello, is that the police? I've just discovered that the friend I buried alive last night is dead.
Mac trojan evades Apple's brand new security fix
Easier said than done
Despite the noise this is a very basic trojan, it doesn't do anything really clever, just relies upon the Safari default "Open safe files after downloading" (this was always asking for trouble), to install an app into the apps folder and add it to the users login items, It throws dodgy porn urls at safari and asks for credit card details but basically it runs in userspace.
Shocking how well they've done for what it is though.
Apple nemesis sues iOS, Mac, and Android devs
Patent bundle
I'm pretty sure this particular patent was just filler in a bundle containing patents that Apple, Google etc actually did need to licence.
I'd imagine no one bothered looking at it too hard, easy to imagine it's not specifically mentioned in rights to app developers and that A&G viewed it as holed by prior art anyway, I doubt anyone except the holder saw this play for small devs.
I suspect Apple will buy one of these companies and throw their legal team at the issue before the patent trolls smell blood.
Pentagon: Hack attacks can be act of war
Can of worms
They are opening there, Still, at least we know the theme of the next bond movie, supervillan/dictator manipulates first world into pounding neighbouring country into stone age, ..., Profit etc
Amazon opens online Macware store
Not really the same thing is it
I don't see licensing for x computers based upon AmazonID, or any sort of upgrade checking / notifications, or one click installs with no messing with serials etc.
This is just a webstore that you can download mac software from, is that a new thing? seems like there are hundreds of websites that have been doing that for ages.
Most read
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- Review Samsung Galaxy Note 4: Spawn of Galaxy Alpha and a Note 3 unveiled
- Webcam hacker pervs in MASS HOME INVASION
- Bada-Bing! Mozilla flips Firefox to YAHOO! for search
- Nexus 7 fandroids tell of salty taste after sucking on Google's Lollipop


text:
Conflict, Time, Photography
Tate Modern, London
Shanghai Biennale
Power Station of Art, Shanghai
Memory Lab: The Sentimental Turn, 6th European Month of Photography,
Berlin, Germany
Scripted Spaces Martos Gallery, LA
The Social Bases of Abstract Art
Up/Down Gallery, Ramsgate, UK
Frutta, Rome
Staging Disorder
London College of Communication, London
Ruin Lust
Tate Britain, London
Art Turning Left: How Values Changed Making 1789–2013
Tate Liverpool, Liverpool
New Photography 2013
MoMA, New York
Curiosity: Art & the Pleasures of Knowing
Curated by Brian Dillon
de Appel, Amsterdam, The Exchange and Newlyn Art Gallery, Cornwall
Tea with Nefertiti
State Museum of Egyptian Art, Munich, IVAM, Valencia, Spain
Unstable Territory
Centre for Contemporary Culture Strozzina, Palazzo Strozzi, Florence
The King's Peace: Realism and War
STILLS, Edinburgh
Divine Violence
Fotografia Europea, Reggio Emilia, Italy
Mystic Fire, Paradise Row, London
CounterIntelligence Justina M. Barnicke Gallery, Toronto, Canada
TJ Boulting, London
C-16: A Group Exhibition
Goodman Gallery Cape Town, South Africa
Conflict: Art and War
Contemporary Art Society, London
Justina M. Barnicke Gallery, Toronto
C-16: A Group Exhibition
Goodman Gallery Cape Town, South Africa
New Photography 2013
MoMA, New York
Death of a Cameraman
apexart, New York
Biel/Bienne Festival of Photography
UK Photography Now: The Constructed View
Dong Gang International Photography Festival 2013, Dong Gang Museum of Photography, Yeongwol, South Korea
Deutsche Börse Photography Prize 2013
The Photographers' Gallery, London
LagosPhoto 2013: The Megacity and the Non-City Art21, Victoria Island, Lagos
Open Heart Surgery
The Moving Museum, The Strand, London
Art Turning Left: How Values Changed Making 1789–2013
Tate Liverpool, UK
Curiosity: Art & the Pleasures of Knowing
Turner Contemporary, Margate, Norwich Castle Museum & Art Gallery, Royal Hibernian Academy, Dublin, de Appel, Amsterdam
Northern Ireland: 30 Years of Photography
Belfast Exposed and The MAC, Belfast
Contact Photography Festival
TPW, Toronto, Canada
Tea with Nefertiti Mathaf: Arab Museum of Modern Art, Doha, Qatar; Institut du Monde Arabe, Paris, France; IVAM, Valencia, Spain
Structures Goodman Gallery, Cape Town
Spring Show
Goodman Gallery Cape Town
Shifting Gazes
Guest Projects, London
Moments of Reprieve: Representing Loss in Contemporary Photography
Paradise Row at The David Roberts Art Foundation
Liquid Archive
Monash University Museum of Art
BredaPhoto- Homo Empathicus
Breda's Museum, The Netherlands
Revive the Visual, Auditory, and Tactile Senses
The JJ-W Hotel, Taiwan
In Appropriation
Houston Center for Photography, Houston
Peripheral Views: States of America
Museum of Contemporary Photography at Columbia College Chicago
Gwangju Biennale
Photography Festival Leipzig
A Refusal of Images
A Space Gallery, Toronto
Lines of Control
Cornell University's Herbert F. Johnson Museum of Art
Critical Dictionary
WORK Gallery, London
Prima Materia
Belfast Exposed Gallery, Belfast
Drawing Show
Paradise Row, London
Advance/ ... Notice
Goodman Gallery Johannesburg, South Africa
Hijacked III: Contemporary Photography from Australia and the UK
Australian Centre For Photography
Hijacked III: Contemporary Photography from Australia and the UK
Griffith University Art Gallery
Hijacked III: Contemporary Photography from Australia and the UK
Perth Institute of Contemporary Arts, Perth and QUAD Gallery in Derby, UK
Out of focus: Photography
Saatchi Gallery, London
Of the Ordinary
The Philadelphia Photo Arts Center, Philadelphia
Machines for Living
Yaffo 23, Bezalel Academy of Arts and Design, Jerusalem
Lines of Control
Cornell University's Herbert F. Johnson Museum of Art
Moments of Reprieve: Representing Loss in Contemporary Photography
Tallinn Art Hall Gallery
Decisive Moments: Uncertain Times
Gallery TPW, Toronto
Collatoral Damage
CUC Centre, Liverpool
Seeing is Believing
KW Institute for Contemporary Art, Berlin
Summer Show
Galerie Gabriel Rolt, Amsterdam
Eat Me
Goodman Gallery, Cape Town
Light II
Galerie Gabriel Rolt, Amsterdam
History Painting Now
Art Sensus, UK
All That Fits: The Aesthetics of Journalism
Quad, UK
FOAM photography Museum, Amsterdam.
Serious Games
Wissenschaftsstadt Darmstadt, Germany.
Focal Point and Beecroft gallery, UK.
La Virreina Centre de la Imatge, Barcelona, Spain.
Home Works V, Beirut Arts Center, Lebanon.
Bringing the War Home
Impressions Gallery, Bradford, UK.
Wolverhampton Art Gallery, UK.
Le Garage
International Photography Festival of Arles, France.
The Marks We Make
The Goodman Gallery, Cape Town, South Africa.
Grand Union, Birmingham, UK.
Manipulating Reality
Palazzo Strozzi, Florence, Italy.
Crisis: Exercises in State of Emergency
Villa Ichon, Bremen, Germany.
Prune: Abstracting Reality
Foam Fotografiemuseum, Amsterdam, Netherlands.
The Edge of Vision: The Rise of Abstraction in Photography
Aperture Foundation, New York, USA.
Miami Basel
The Goodman Gallery, Miami, USA.
Art Basel
The Goodman Gallery, Switzerland.
Gammel Holtegaard Museum, Copenhagen, Denmark.
The Past in the Present – Questioning History
Dutch Photomuseum, Rotterdam, Netherlands.
Embedded Art
Akademie der Kunst, Berlin, Germany.
La Terra et Nous
La Cite des Sciences et de l'Industrie, Paris, France.
The Sublime Image of Destruction
The Brighton Photo Biennial, Brighton, UK.
La Terra et Nous
La Cite des Sciences et de l'Industrie, Paris, France.
The Photographic Portrait in the 20th Century
Fondazione Ragghainti, Lucca, Italy.
Zoo Art Fair
Paradise Row, London, UK.
Echo Wanted
Galerie Karsten Greve, Paris, France.
Mini-Israel and Bambi
Screening at The Gate Cinema, London, UK.
East Wing VIII
The Courtauld Institute, London, UK.
Sleeping and Dreaming
The Wellcome Trust, London, UK.
Block 180
The Hospital, London, UK.
Zoo Art Fair
Paradise Row, London, UK
Paris Photo
Steidl, Paris, France.
Zelda Rubinstein, A Group Show
Paradise Row, London, UK.
On the Wall
Aperture Foundation, NY, USA.
Ecotopia: the Second ICP Triennal of Photography and Video
Global Cities: the 10th International Biennale of Architecture
Venice, Italy.
1+1=3, Collaboration in Recent British Portraiture
Freemantle Arts Centre, Australia.
The Face of Madness
Palazzo Magnani, Italy
New Photographers 2006
Museum voor Fotografie, Belgium.
Durban Museum, South Africa.
Reykjavik Museum of Photography, Iceland
The National Museum of Photography, Denmark
Kristanstads Konsthall, Sweden
Aranjuez, Photo Espana, Spain
History in the Making
Circulo de Bellas Artes, PhotoEspaña, Spain.
Stepping in and out: Contemporary Documentary Photography
The Victoria & Albert Museum, UK.
It's Wrong To wish On Space Hardware
Gardener Art Center, Brighton University, UK
In A Lonely Place
The National Museum Of Photography, Film and Television, UK.
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text:
Retaliation Lyrics - A Canorous Quintet
Hate has bleeding within me
I am turned inside out
Wish you felt the pain i feel
A thorn tearing from inside
I bleed the invisible blood
The blood of my soul
I wish i had the strength to turn my back
Turn my rage against you
Make you bleed the way i do
Bury you within my darkness
Stifle in my close embrace
Until there's nothing left to hate
Only the purity of a newborn life
[*] condemned because there is no cause
Seas of sorrow drowing me
I'll live forevermore still nevermore
I'll become your greatest fear
Take you down to me
To perish in hy heart of darkness
Until the end of time
Until the end of time
In this world of pain
Sorrow is all you'll gain
You get what you deserve!
Your daydreams end!
Inside this blackhole of my life
Nothing can exist no more
Forever engulfed,
Forever lost, within myself
Within hy tihe
[Repeat verse 2]
Click here to submit the Corrections of Retaliation Lyrics
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A. Che™ (ay-shay) designer Amanda Che is a California native from Calabasas. Amanda had an eye for fashion early on. At the age of 13, she began working in a family business manufacturing lingerie and swimwear. She learned the basics and then explored all the facets of a fashion brand and business.
A. Che's collection is unique because it integrates intimate apparel construction with the latest technology to create an exceptional fit and style details. The swimwear features fine Italian fabrics and bra-style molded cups, designed for the sophisticated women looking for sultry styles, fit, and flare.


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Wow, simply wow!
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November 28, 2014
Ask any Virginia football player, and they'll tell you that one of the biggest differences from last year to this year is the team's unity. The Cavaliers insist that the team grew closer during the offseason, after finishing 2-10 in 2013. But that doesn't mean they've been taking it easy when they go up against one another on the field during training camp.
"Those defensive guys are out there flying around, and that's a good thing, that intensity level," said senior running back Kevin Parks. "That's how it'll be in the game, so you want guys out there flying around and you want to be able to match their intensity."
The Cavaliers are nearing the end of their first week of fall camp. They held their first scrimmage of the week on Saturday, which also marked the start of two-a-days.
"You have to have that edge and show that passion to make everyone else better," said junior defensive end Eli Harold. "You just lay it all out on the line. That's what I try to do every play, whether I've got to smack a guy in the face to get him right, because I'm going to need you to get me right."
As practices continue, the 'Hoos are getting closer to their season opener against UCLA on Aug. 30. Linebacker Henry says the Cavs plan to keep up the intensity in practice over the next few weeks, as they get ready to face the Bruins.
"You get the best out of guys, you know. A lot of guys are chippy or whatnot, you just get the best out of guys."
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17 Feb 2012 11:32:26
LNG bunkering and small-scale services could bring a new dimension to the planned 8 billion cubic metre/year Fos Faster terminal in the south of France, according to the head of project operator Fos Faster LNG.
The results of a non-binding market consultation for the project development late last year were labelled as "encouraging", despite a difficult LNG market in Europe.
Philippe Cracowski, president of Fos Faster LNG, said the consortium, owned by Netherlands-based infrastructure developer Vopak (90%) and Shell (10%), is looking to explore its existing and forecasted services portfolio including small-scale LNG, in a similar fashion to a number of terminals in northwestern Europe, including the Gate terminal in the Netherlands and France's Montoir facility.
"Should demand be there, we could decrease regasification capacity and increase volumes allocated to bunkering and small-scale projects," Cracowski said. No details were available on the market's interest as the project moves towards binding discussions with interested companies.
Small-scale LNG infrastructure is flourishing across Europe as the industry sees it as a growth point, able to bolster European gas demand in the future.
Nevertheless, uncertainties remain regarding the extent of the demand and realisation of this type of infrastructure.
Fos Faster LNG also said the company was on track to start commercial operation late in 2017 or early 2018, according to initial schedules. The final investment decision is expected to be taken in 2014.
Key steps in the coming months will be the application for third-party exemption by the Commission and tying supply contracts with customers, Fos Faster LNG emphasised.
The terminal project is initially mapped out to include one jetty for all types of LNG vessels and two tankers of 180,000 cubic metres for a total initial investment cost estimated at €750m ($982m). The facility could be expanded to two jetties and four storage tanks in a subsequent phase.
New developments on the French gas market in 2011 have given the project new momentum. A decision by transmission system operator GRTgaz last year to strengthen the grid in France's southern balancing zone, should accelerate the merger of the isolated PEG Sud area to northwest Europe's integrated and liquid network.
Separately, connecting the Fos Faster project to the French grid will not require any new investment. The pipeline, built to connect the Fos Cavaou terminal in the same area, was built with the view to connect another regasification unit in the Marseilles region.
24 Nov 2014 17:40
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Humidity 69%
Winds 12.7mph
Humidity 69%
Winds 12.7mph
Aug 21, 2014 3:46 AM by Stormtracker Meteorologist Tom Ackerman
All is quiet early Thursday morning, we're partly cloudy & warm- in the upper 60s to low 70s. I'm keeping an eye on a weakening round of showers & storms over southern Indiana that's tracking east and may impact western counties in a few hours. Better chances for another round of scattered strong to severe storms exists this afternoon. I'll have more on the storm threat and the hotter & sticky weekend that's on the way coming up on LEX 18 News at Sunrise.
4 hours ago


text:
Carrie, Taylor, Nicole and more dazzle on the red carpet for country music's hottest night of the year
Credit: Peter Kramer/AP
Updated: Wednesday Nov 11, 2009 | 09:20 PM EST
By: Katherine Kluznik Rentmeester
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See the stars as they arrive on the red carpet
1 of 13
The CMA Awards' sexy host – and female vocalist nominee – starts off the night in style, in a platinum jeweled Theia gown. But she promises that there'll be more to come! "I'm not going to keep this one on all night," she says on the red carpet. "I'm supposed to have nine [costume changes] during the show."
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November 28, 2014
By: Lanetra Bennett
August 15, 2013
Thursday was the first day of school in Wakulla County and other area Florida schools begin Monday, August 19th.
Leon County administrators want to remind drivers to watch out for school buses.
Leon County buses make about three-thousand stops every morning and every afternoon.
Administrators ask that motorists take heed to the stop signs and lights on buses and pay attention to kids getting off.
Bus drivers say that would give them one less thing to worry about.
Rozzell Jones has been driving for Leon County Schools for about three years. He says, "You have distractions along with the kids in the back of the bus and with the cars approaching the bus stop, also. So, it's definitely going to be distractions. The main thing is stay cool, stay collected, and look at your surroundings."
Leon County newer buses have four to six cameras, one that catches cars that don't stop when they're supposed to.
Other safety features include GPS and panic buttons for bus drivers.
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text:
Hundreds evacuated and 14 people injured after gas explosion at central London hotel
Some 500 guests were evacuated and 14 people were injured after an explosion at a top central London hotel caused part of the building to collapse.
Police have released an image of a woman who was killed after being hit by a car at a busy junction in south London.
28 January 2014
Elephant and Castle is set to rival Shoreditch with its own shipping container pop-up mall.
24 December 2013
South London's notorious Elephant & Castle shopping centre - once famously painted bright pink to make it less depressing - has been sold to developers for £80m million.
03 December 2013
A man who was fatally stabbed outside a pub is believed to have been a victim of mistaken identity, police said today.
01 December 2013
A rapist has been jailed for eight years after an "evil" sex attack on a woman who was waiting for a bus home on a night out.
25 November 2013
A rapist has been jailed for eight years after an "evil" sex attack on a woman who was waiting for a bus home on a night out.
25 November 2013
The last resident of a housing estate that is being demolished to make way for a £1.5 billion regeneration project has been evicted by police.
08 November 2013
A brand new shopping centre at Elephant and Castle looks set to become the centrepiece of a £1.5 billion regeneration project now under way in Southwark. Sources at the council say control of the existing "pink elephant" centre will pass from owner St Modwen within a few weeks, barring a breakdown in talks.
26 September 2013
Southwark council is going to a tribunal to challenge a ruling that it must be transparent over the £1.5 billion redevelopment of the Heygate Estate.
11 September 2013
A London borough today announced plans to build 10,000 council homes to tackle the capital's affordable housing crisis.
17 July 2013


text:
Microsoft to slot ActiveSync into Hotmail
Microsoft will show some much-needed love into Hotmail next week, by adding Exchange ActiveSync to the webmail service. ActiveSync was licensed by Apple in 2008 and by Google in 2009. Other phone makers that are also paying Redmond big bucks to use the service - Microsoft's protocol to push email from a server to a client - …
oh :(
why cant i just have smtp supprt so i can have exchange for work .....
Push Hotmail?
Sorry for the daft question but I'm very tired...
So this is Hotmail being 'pushed' to my iPhone then?
If so... (drum roll) Well done Microsoft?!
ActiveSync. Good, but...
...there are some very good existing open protocols for mail and calendars that MS choose to neglect year on year.
It really would be nice to see a proper IMAP implementation in Outlook, (IMAP IDLE anyone?) combined with Caldav calendar support. Oops dreaming again, that might mean Outlook integration with non-MS software.
Beer cos it's Friday. Where's that bar steward......
This is great news!
How about fixing Hotmail FIRST?
Ever since Microsoft decided to improve it, Hotmail has turned to cr*p.
It takes forever when it decides to do anything at all.
It loses connection to their mail server but does not tell you even if you refresh so you do not get your messages timely.
You are expected to page back through months of email, one screen at a time, no jumping back a number of pages.
Live mail connector send function doesn't work most of the time.
As mentioned it does not support Imap or Pop.
It no longer tells you what Hotmail account you are in, a disaster if you have multiple accounts.
Download is now cr*ppy and confusing.
Microsoft used to have the BEST product managers, not the worst. HOW DID THEY DEPLOY THIS THING? DON'T THEY EAT THEIR OWN DOG FOOD? IS EVERYONE AT MICROSOFT USING GMAIL SO THEY DO NOT NOTICE?
Oh great
Yet another HotFail innovation nobody asked for that will go snap like all the other new "features" they've been bolting on lately.
More like Spam Mail, every mail sending bot knows to bomb it. I left mine alone for a month and it just collected crap like 500 plus Spams. Maybe thats why I am SO glad it dont do SMTP, just imagine being the idiot that lets Hotmail into your e-mail proggy and hey presto spam and Virii all over your nice pooter. Be Careful what you wish for Lionel Baden ..
Oh and Hotmail did do smtp at one stage way back when Adam was a cowboy...
Sync with Hotmail and not Windows?
One of the worst things of WIndows mobile is you can't sync your phone but with Outlook (without using third party tools), because it can't sync with Windows Mail and the like. That made WinMo a problem for all those user that have not Outlook already (especially at home). A real nonsense if you wanted to expand its use.
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The independent rating services regularly examine our company, and give us their ratings, based on our financial strength, overall operation and claims-paying ability.
Northwestern Mutual has the highest financial strength ratings awarded to any life insurer by all four of the major credit rating agencies.
Ratings are for Northwestern Mutual Life Insurance Company and Northwestern Long Term Care Insurance Company, as of the most recent review and report by each rating agency. Northwestern Mutual's ratings: Moody's Investors Service Aaa (highest), 6/2014; A.M. Best Company A++ (highest), 4/2014; Fitch Ratings AAA (highest), 11/2014; Standard & Poor's AA+ (second highest), 7/2014. Ratings are subject to change.
"The ratings reflect "the company's exceptional intrinsic strengths, including leading positions and strong franchise in its core markets, including a significant focus on participating whole life, leading position overall in individual life insurance, excellent distribution channel, strong underwriting skills as shown by excellent persistency and mortality experience and robust and resilient balance sheet."
Moody's Investors Service, 6/2014Ratings Report
"The ratings reflect Northwestern Mutual's sizable and mature participating ordinary life insurance business, overall positive operating performance and strong risk-adjusted capitalization. The ratings also recognize the loyalty and productivity of the company's exclusive distribution system, as well as the competitive advantages derived from historically favorable investments, expenses, persistency and mortality experiences in its core business lines."
A.M. Best, 4/2014Press Release
"Fitch's ratings reflect Northwestern's leading competitive position in the U.S. individual life insurance market, extremely strong balance sheet fundamentals and stable earnings profile. Fitch considers Northwestern's key competitive advantages to include its successful distribution system, large and stable block of traditional life insurance and expense advantage relative to peers."
Fitch Ratings, 11/2014Press Release
"Northwestern Mutual has an extremely strong competitive position, which reflects a strong and respected brand, a competitive product portfolio and leading operating fundamentals relative to peers'."
Standard & Poor's, 7/2014Ratings Report


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Save to My Recipes
Spanish Grilled Cheese Sandwiches with Manchego and Jamón Serrano
Servings: makes 2
- 3 tablespoons butter, room temperature
- 4 slices firm white sandwich bread
- 6 ounces Manchego cheese, thinly sliced
- 4 ounces thinly sliced jamón Serrano or prosciutto
- 4 Medjool dates, pitted, chopped
PREPARATIONView Step-by-Step Directions
Line baking sheet with waxed paper. Spread butter on bread slices, dividing equally. Place 2 bread slices on prepared baking sheet, buttered side down. Top bread slices with half of sliced cheese (1 1/2 ounces each); top cheese with ham, dividing equally. Sprinkle dates over. Top with remaining cheese, then remaining 2 bread slices, buttered side up. Refrigerate 30 minutes. DO AHEAD Can be made 8 hours ahead. Cover with plastic wrap and keep chilled. Peel plastic from sandwiches before continuing.
Heat panini press and cook sandwiches according to manufacturer's instructions. (Alternatively, heat heavy large skillet over medium-high heat. Reduce heat to medium-low. Place sandwiches in skillet. Place another large skillet atop sandwiches; place weight, such as large can of tomatoes, atop skillet. Cook sandwiches until golden brown and cheese melts, about 4 minutes per side.)
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Santa Maria Delays Expected During Water Main Repair
Updated On: Sep 14 2013 12:22:07 AM CDT
Utility crews in Santa Maria will be working on identifying and repairing the cause of a water leak in the 400 block of South Broadway.
The repairs will begin at 9 a.m. Tuesday, Sept. 17 in front of City Hall.
Work is expected to continue throughout the day and will involve temporary lane closures and partial obstruction of the sidewalk in that area.
For more information or questions regarding this repair work, please call the Utilities Department office, 925-0951 ext. 7270.
Copyright © 2013 KEYT - NPG of California, LLC. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.


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Cheil will handle the Digital part of the media business while Lodestar will handle the rest of the business including ATL. The business is estimated to be worth Rs 500-600 crore
BestMediaInfo Bureau | Delhi | December 24, 2013
IPG Mediabrands is ending the year with a huge bang. Close on the heels of the announcement last week that it had… Continue reading Lodestar-Cheil combine wins Samsung media mandate