text:
East-Elmhurst Dating and Personals
Dating, Personals,and Singles near East-Elmhurst, NY
Featured profiles from Match.com
Jackson Heights, NY | Age: 44 b3351
I've been fortunate to live in several places in the US: New England (many doughnut shops), the Midw...
New York, NY | Age: 28 RDNYC86
"Stimulate my mind, and I'll give you the rest."
Faith is a huge part of my life and I want to share that with someone. Intellectual banter intrigues...
- Register FREE to check out more than 6,769 photos of singles in East-Elmhurst.
New York, NY | Age: 34 onobrewerb
"I am easy going, outgoing and social lady."
I am looking for someone with similar interests, morals, and values. Someone who is attentive and a ...
Jamaica, NY | Age: 41 Toria_De
"Im a person that loves to smile. Great smiles run in..."
Im an easygoing friendly person that enjoys conversation and getting to know a person. Im ambitious ...
Brooklyn, NY | Age: 35 little_snack
"I like to walk on the sunny side of the street."
I'm looking for someone to do stuff with. I like exploring and going on little adventures. I would l...
Brooklyn, NY | Age: 36 Sireen_S
"Here we go!"
I am a down to earth person who loves to have fun and loves meeting interesting and smart people. I ...
Brooklyn, NY | Age: 39 SHY82927
"Life Is About Choices, I Have Chosen Happiness Today!"
Im a woman of colour with great personallity; i admire genuine people who act with empathy, Im looki...
Flushing, NY | Age: 32 agunia13
"True love comes unexpectedly........"
Hi! I'm looking for honest man, warm, funny who no matter what will love me! Be always by my side, ...
Brooklyn, NY | Age: 29 newtony5431
"Looking to share my happiness with someone else! Let..."
I am an aspiring journalist and am currently enrolled in a graduate program here in NYC. Im original...
Brooklyn, NY | Age: 35 Lovely__Lynn
"Mountain girl with a heart made of coffee."
I love camping under the stars, hiking and nature but in NYC I'll settle for the twinkle of city l...
Jamaica, NY | Age: 35 janeignacio508
"If your true, good person, and serious then write me :)"
I have a great sense of humor. Very caring, honest and God fearing. I like somebody whose the same a...
Middle Village, NY | Age: 28 JohannaNYC3
"What's life without love and laughter!"
I am fun loving, laid back, funny, thoughtful and kind. Very artistic and creative and love what I d...
Flushing, NY | Age: 36 gummi6ear
""The purpose of our lives is to be happy""
Friends describe me as easy-going and independent. Love to travel and looking for someone that can m...
Astoria, NY | Age: 35 lomonomo7017
"Keep Calm and Carry On"
I'd say I'm motivated, outgoing, kind, independent, goofy, intelligent and very friendly. I love ran...
New York, NY | Age: 33 M9ynx9
"Confidence makes a girl sexy"
Hi, I'm very active and always on the go. I'm told I'm a guys gal...love football (Go Giants), Yank...
New York, NY | Age: 27 msteacher780
"looking for mr right ;)"
looking for mr right. my name is Nicole. i am an elementary school teacher. i love children. i ...
New York, NY | Age: 41 Agirlfrom73
"World traveler, career woman finally looking for tha..."
I was born and raised in Buenos Aires, Argentina but the last 14 years I lived elsewhere. Mexico Cit...
Astoria, NY | Age: 27 LaurenRN917
"Well, hello handsome ; )"
My name is Lauren, I am a quirky, caring, smart lady. I'm a nurse in the city and am pursuing a gra...
New York, NY | Age: 39 NY_LA_NAK
"My family and small group of friends (who are..."
My family and small group of friends (who are more like family) are pretty special to me. I work in ...
New York, NY | Age: 25 WandaSz
"Fall in love, stay in love and it will determine eve..."
Fun-loving and at times clumsy Polish girl who wants to find her partner in crime. I'm a sucker for ...
New York, NY | Age: 26 Sophia02225
"I never thought i'd be on Match.com!"
I am a 26 year old female, born and raised in Manhattan. I have been living out in Colorado for the ...
New York, NY | Age: 34 LadyRun212
"Looking for a running mate, you up?"
I am a kind, friendly native New Yorker who loves the arts and staying fit and healthy. I am lookin...
Flushing, NY | Age: 37 iluvheelz
"So you found me..."
I am an active girl and loves to be outdoors. I don't think I'm the typical girl, don't get me wrong...
New York, NY | Age: 31 magannyc
"New to NYC and loving it! Also new to online dating..."
New York, NY | Age: 35 travelnfun26
""The world is a book and those who do not trave..."
I consider myself laid back but very responsible. I enjoy the company of great friends and family. ...
Brooklyn, NY | Age: 40 sweetsweet_b
i like people who make things, fix things, turn an idea on its head. and laugh. someone who wants to...
Flushing, NY | Age: 44 style1016
"looking for honesty, sensitivity, sable, truthful,fu..."
I am a 44, very independent, divorced, self sufficient, very blunt, funny, always laughing because I...
Brooklyn, NY | Age: 26 crash174a
"I'm in love with cities I've never been to and peopl..."
My friends would describe me as quirky, sarcastic, and occasionally a healthy dose of sass. I'm look...
Flushing, NY | Age: 38 Grocka513
"Looking for something serious"
I'm 38 mother of 2 a boy and a girl.I like jogging, Zumba, hiking, swimming, movies, all kinds of mu...
Flushing, NY | Age: 37 Wangluxia
"After rain comes always sunshine"
Family and friends are important in my life. My friends say that I 'm easy to get along with ,honest...
Register FREE to check out more than 6,769 photos of singles in East-Elmhurst.
Copyright © 2014 Topix LLC


text:
Greece's Herculean task is to survive a recession as big as the Wall Street Crash
Monday 16 September 2013
Amid the frenzy of strikes, street protests and stalled negotiations it is difficult to get a clear picture of whether or not the two debt bail-outs for Greece are working. The renewed speculation that Greece might need further support next year adds further concern.
Soon Greece will have gone through a recession similar in size to that of the Wall Street Crash of 1929. If the task remains Herculean, the experience has appeared akin to that of Sisyphus.
Progress has been made on the core issue. In the first year of the crisis, Greece achieved the biggest deficit reduction recorded by any European economy in the post-war period. Last year, its budget consolidation was ahead of target and in 2013 it may well achieve a primary surplus (net of interest repayments). Currently, only Ireland is out-performing Greece in its budget consolidation effort.
Yet with their deficit reductions, both Ireland and Portugal are enjoying much better rates of economic growth. Greece may not return to growth until next year. And the social pain in Greece creates a cauldron for popular protest. Two out of three young people are unemployed, public sector salaries have been slashed, and bankruptcies have exploded. Some months ago, the IMF admitted it had wrongly estimated the 'multiplier' effects of the cuts it insisted upon.
Greece needs investment in growth and it has sectors that offer good returns. But, not only has the rescue so far had the wrong speed, its direction has also been wanting. Given Greece's record on structural reform, the 'troika' overseeing its bailouts opted for crude, across-the-board savings. So, this week's protests over public sector job cuts are both correct in the sense that the target figures are not the result of any serious review of what resources and skills the state administration needs, but wrong in dismissing evidence of under-performance and wastage. The target figures for job cuts follow a purely fiscal-savings logic.
Thus, the bargaining between the troika and Athens does little to focus attention on reform priorities. The Opposition is encouraged to defend every last job, making the state sector a poor substitute for an all too absent welfare regime.
And, after all the painful measures, the best Greece can hope for in 2020 is to have a debt burden higher than the one it had at the start of the crisis.
Professor Kevin Featherstone heads the LSE's Hellenic Observatory.
Newcastle winger is in Argentina having chemotherapy
Returning to the stage after 20 years makes actress feel 'nauseous'
Man's attempt to avoid being impounded heavily criticised
- 1 Scottish independence: Ireland since 1919 is a lesson for Scotland in what a Yes vote means
- 2 A bottle of wine a day is not bad for you and abstaining is worse than drinking, scientist claims
- 3 Grandmas keep accidentally tagging themselves as Grandmaster Flash on Facebook
- 4 Daniele Watts: Django Unchained actress detained by Los Angeles police after being mistaken for a prostitute
- 5 Kanye West halts concert after two fans don't stand up - doesn't realise one is in wheelchair and the other disabled
Islamic State: Pope is 'being targeted by Isis', Iraqi ambassador to the Holy See warns
Jennifer Lawrence and Kate Upton nude pictures exhibition cancelled after artist concedes photos were 'stolen property'
Scottish independence referendum: A nation divided against itself
John Travolta addresses former pilot's gay romance allegations publicly for the first time: 'That was the lowest I'd ever felt'
Richard III: Two years after his body was found scientists discover how he died
Daniele Watts: Django Unchained actress detained by Los Angeles police after being mistaken for a prostitute
The political class is doing what Hitler couldn't – destroying Britain
Scottish independence: Nationalist leader Jim Sillars threatens pro-union companies with 'day of reckoning' after independence
Scottish independence: Yes campaign feels the heat as Alex Salmond's NHS claims come under furious attack
Portuguese academic says British are 'filthy, violent and drunk'
£23m Birmingham cycle scheme is attacked by Tory councillor for not catering to the elderly
i100: A single mother on benefits who became one of the world's most successful authors
11 rags-to-riches underdog success stories
Forget top summer reads
here are our top five summer listens
A Brave New Season
Brogues vs trainers. The great winter coat debate. Shape-shifting silhouette PLUS win the edit
Get Reddy
For a hint of autumnal elegance opt for boozy hues of tomato, rouge and claret. Get reddy says Melanie Wilkinson
Get the look. See the trends.
Westfield and Snapfashion team up to create a new digital styling tool. Create a style board or browse this season's trends. #editme.
Jake Bugg: "I'm the one I have to answer to…"
Fresh out of his teenage years, singer-songwriter Jake Bugg has achieved the kind of success that most aspiring musicians can merely dream of.
Enter the latest Independent competitions
Win anything from gadgets to five-star holidays on our competitions and offers page.
Business videos from commercial thought leaders
Watch the best in the business world give their insights into the world of business.
Independent Dating
iJobs General
March On Cancer™ - Local Marketing and Promotions Volunteer
This is an unpaid voluntary role.: Cancer Research UK: We need motivational vo...
Maths Teacher - Evening session
Negotiable: Randstad Education Birmingham: I am looking for a qualified experi...
Teaching Assistants
£50 - £85 per day: Randstad Education Preston: Rapidly developing and growing ...
Supply Teachers needed in Stowmarket
£1034496 - £1516224 per annum: Randstad Education Cambridge: The Job:Randstad ...

subset: commoncrawl


text:
3 Simple (But Effective) Ways To Take Control of Your Personal Debts
No matter the scale of your financial crisis, there is always a way to handle it now to prevent..
Digging Out of Student Loan Debt
Many Americans refinanced their homes at the start of the 2008 recession; the decision helped..
Practical Ways to Get Out of Debt
While some debt, like mortgages, is not necessarily bad, too much of it can cripple a person's..
Debt Financing: Is it Appropriate for Your Startup?
Startups are always looking for the best finance option available. High percentage of new..
Organize And Reduce Your Debt With Newly-Released "Pay Off Debt Lite" For The iPhone
Pay Off Debt intends to help you reduce and clear your debts right on your iphone. Pay Off Debt..


text:
Review Roundup: Lindsay Lohan Stars in Lifetime's LIZ & DICK
Lifetime's original movie LIZ & DICK, which chronicles the rocky relationship of legendary stars Elizabeth Taylor and Richard Burton, premiered on the cable network last night, Sunday, November 25th. Directed by Lloyd Kramer, the film stars Lindsay Lohan as Taylor and Grant Bowler as Burton. The script was written by Christopher Monger and produced by Larry A. Thompson.
Let's see what the critics had to say:
Tim Goodman, The Hollywood Reporter: Lohan is woeful as Taylor from start to finish. But, whatever you do, don't miss Liz & Dick. It's an instant classic of unintentional hilarity. Drinking games were made for movies like this. And the best part is that it gets worse as it goes on, so in the right company with the right beverages, Liz & Dick could be unbearably hilarious toward the tail end of the 90-minute running time. By the time Lohan is playing mid-'80s Taylor and it looks like a lost Saturday Night Live skit, your body may be cramped by convulsions.
Maureen Ryan, The Huffington Post: 'Liz and Dick' is badly paced, cheap-looking and encrusted with a tinkly, preposterous soundtrack that is designed to make viewers go insane. It's also littered with exposition-heavy segments in which Liz and Dick reminisce about their past, perhaps from beyond the grave. In those segments, they wear matching black ensembles and essentially narrate their own lives, much to their own amusement. In doing so, they make these rich and eventful lives sound a lot less interesting than they actually were.
David Wiegand, The San Francisco Chronicle: From a distance, and perhaps more so when she was younger and her notorious partying hadn't started to show on her face, Lohan bears a certain resemblance to Taylor. But it's not enough by half to make her credible here. For one thing, virtually no attempt has been made to reflect Taylor's physicality. Unlike Lohan, she had hips. And at certain times during the period the film covers, she had a lot more than that. The recreated scene from 'Virginia Woolf' is absurd: It's as though Burton is trading barbs with a 14-year-old boy in drag.
|Related Links
|Shonda Rhimes Responds to New York Times' 'Angry Black Woman' Quip
September 19, 2014
|Lifetime's Original Movie PETALS ON THE WIND Delivers 3.4 M Viewers
May 28, 2014
About Author
- THIRTEEN Premieres Treasures of New York: Columbia University Tonight
- CBS Airs 'Doubleheader' Premiere of MADAM SECRETARY, Starring Patina Miller & Bebe Neuwirth, Tonight
- LMN Premieres New Movie THE HAZING SECRET, Starring Keegan Allen, Tonight
- Cardinals Hosts Reds in ESPN's SUNDAY NIGHT BASEBALL Season Finale Tonight
- Smithsonian Channel Premieres Two-Hour Special STONEHENGE EMPIRE Tonight
- ESPN Premieres 3-Part Series World of X Games: Big Wave Hellmen Today
- Sneak Peek - Parenting Expert Dr. Shefali Tsabary on All-New OPRAH'S LIFECLASS Tonight
- NBC Sports Presents Formula One at Singapore Grand Prix Today
- Sneak Peek - Alanis Morissette Featured on Oprah's SUPER SOUL SUNDAY Today on OWN
- TITULARES TELEMUNDO Presents Exclusive Interview with Jorge Luis Pinto


text:
Twin Pillars
Patrick Clinton is Pharmaceutical Executive's Editor-in-Chief.
At the sprawling Roche Pharmaceuticals campus in Nutley, New Jersey, the US headquarters of the Swiss-based company, dominating the lobby of the main building stands a statue of a winged horse—white, alert, poised for flight.
Winged Pegasus, poised for flight, may be an apt image for the company as well. After a tough spell that led to significant layoffs and restructuring in 2001, Roche stripped away noncore businesses, filled in a strong pipeline of products, trained a powerful sales force—and, last month in its annual report, announced a return to profitability, driven by a growth in pharma sales of more than 20 percent in local currencies.
A winged horse is a combination of two disparate things that yields something more potent than either. Again, not a bad image for a company that has staked its future on a strategy of combining drugs with diagnostics. With the success of Herceptin (trastuzumab) as a model, the company has restructured itself to take maximum advantage of synergies between its pharmaceutical and diagnostics divisions.
There's a third way to look at the mythical creature: It's something never yet seen on earth. And that's relevant to Roche too. The company's portfolio of personalized medicines, seamless integration of drugs and diagnostics, and "hub and spoke" management, is very much a work in progress. The horse in the lobby is a reminder, that in a fast-changing industry, if you're not flapping your wings as hard as you can, if you're not executing, the most potent vision can turn out to be, well, horse feathers.
Curing the Hiccough
George Abercrombie is the president and CEO of Roche North American Pharmaceutical Operations and a 20-year veteran of the industry, but he got his start as a retail pharmacist. After earning his degree from the University of North Carolina at Chapel Hill, he practiced for three years in the Blue Ridge Mountains before moving on to business school and a career that took him to Merck, Glaxo, and, in January 2001, to Roche. "When I was a pharmacist, the products in the fastest moving section of the pharmacy were Valium, Librium, Dalmane, Librax—all Roche products," Abercrombie says. "It's a great company with a great legacy."
Legacy notwithstanding, by the time Abercrombie arrived in New Jersey, Roche was having problems. In the mid-1990s, the company had experienced a "hiccough" in the research pipeline, as CEO Franz Humer described it. By 2001, pipeline issues were affecting the balance sheet.
"On the plus side, I found an incredibly devoted, smart, dedicated work force with tremendous loyalty and pride in the company's legacy. I found a research pipeline and a product portfolio that, at the time, was generally underestimated outside the company. And I found a group of employees and team members who really wanted to be winners. To me that's half the battle."
Within six months, a painful round of layoffs was complete. "To the credit of the employees, many said that they saw it coming and that somebody had to do it," Abercrombie says.
The company, meanwhile, had already begun working on its pipeline. Humer hired Jonathan Knowles to lead global research, Ed Holdener to lead global development, and Lee Babiss to head global preclinical development—a job that expanded to include the crucial areas of overlap between pharmaceuticals and diagnostics. Roche also picked up the pace and sophistication of its deal making. By the time Abercrombie finished his rationalization in North America, things were already looking more hopeful. "Coming out of that period, we took a look at our existing portfolio," Abercrombie says, "and we said that we had a great portfolio. If you look at our existing products today—we have about 10–12 promoted products—nine of those are market leaders in their therapeutic classes; a couple are No. 2, in terms of market share."
To get maximum benefit from that portfolio, Roche decided to upgrade its sales force. "We determined that sales force effectiveness is a key driver to the business in the US," Abercrombie says. "We said, 'We want to have the most effective sales force in the business.' So we undertook an initiative to enhance our training, to enhance district manager coaching and counseling. We upgraded dramatically our sales force automation system." The payoff: a sales force that in three of the past four surveys conducted by Health Strategies Group has ranked first in sales force effectiveness.
The pipeline, the financial rationalization, and the attention to sales force were all important. But just as important, a new model was emerging. Innovation, long a key Roche value, took on new meaning as the company stripped away noncore activities, including its vitamin and fine-chemicals divisions. (The company recently announced its intention of selling or spinning off its nonprescription drug business.) Meanwhile, the old holding company model was giving way to a new "hub and spoke" approach, and a new commitment was emerging to what Roche calls the "twin pillars" of drugs and diagnostics.
Coping With Innovation
Late in the 1950s, Roche's legendary chemist Leo Sternbach was winding down a research program. He had been searching for a drug to control anxiety, and the quest hadn't gone well. Then, almost as an afterthought, he had tests run on one last sample, the last result of an abandoned line of exploration.
"Valium was a true innovation in its day," says Abercrombie. "It was the leading prescribed product in America from 1969 through 1982. And it represented the first blockbuster. It was a major product that put Roche on the map. And it is truly an icon in its own right."
For Roche, which at times derived as much as a quarter of its revenue from Valium, the drug was an example of the power of a truly innovative product. The lesson stuck. Over the years, the company has demonstrated a preference for drugs that open categories and introduce new methods of action. The current portfolio includes Fuzeon (enfurvitide), the first HIV drug to operate by fusion inhibition, Xeloda (capecitabine), the first oral chemotherapy drug for late-stage metastatic breast and colon cancer, and Invirase (saquinavir), the first protease inhibitor, to name just three.
Roche frequently partners with Genentech (it holds a majority of the company's stock). And outside the United States, Roche markets such groundbreaking Genentech drugs as Herceptin, the first oncology drug to be paired with a matching diagnostic that determines whether the cancer is likely to respond, and MabThera/Rituxan (rituximab), the first monoclonal antibody for non-Hodgkin's lymphoma (NHL).
"Building a brand is all about providing therapies that are meaningful to patients," says Abercrombie. "If you do that well, then recognition comes as a consequence. If your product doesn't work, if it doesn't offer an advantage, the name recognition will never be there. It's all about innovation."
Innovation presents its own challenges, as is illustrated by the case of Fuzeon, which was developed in partnership with Trimeris, a biopharmaceutical company based in Durham, North Carolina.
"I believe Fuzeon represents the best of Roche and the best of the research-based pharmaceutical industry," says Abercrombie. "In every regard, Fuzeon is unprecedented. It is one of the most complex molecules ever manufactured on a large scale. If a table is the size of a protease inhibitor, Fuzeon is the size of a room—a protein made up of 36 amino acids. It takes six months to make a batch, 100 manufacturing steps compared to 10 for a protease inhibitor. The cost of goods is 10–20 times that of a protease inhibitor. The process is so complex that many skeptics said it could never be done.
"Conventional therapy attacks the virus once it is inside the cell. Fuzeon prevents the virus from entering the cell. This is a totally new mechanism of action that offers the ability to build combination therapies that attack the virus at more points in its life cycle, as well as a way to beat forms of the virus that have become resistant to therapy."
Fuzeon was expensive to develop and is expansive to manufacture, so the company charges approximately $20,000 a year for it. That means that it was essential to work carefully with Medicare, managed care, and other payers. The effort paid off, and Trimeris' CEO Dani Bolognesi recently announced that 94 percent of the 142 largest insurance companies had agreed to cover the drug, including United Healthcare, Aetna, Well Point, CIGNA, Kaiser, Humana, Health Net, and Blue Cross Blue Shield. The drug is also covered by 34 AIDS drug assistance programs (ADAPs).
In addition, as a protein, Fuzeon is a twice-a-day injectable in a field dominated by oral drugs. "We knew patients would have to get accustomed to a twice-a-day injection," Abercrombie says. "We have programs where patients can phone a call center with nurses to help them walk through how to self-inject. In another program, nurses go to the physician's office or the patient's home to coach them. In major metropolitan areas across the country, AIDS service organizations are sponsoring programs where a Fuzeon patient stands in front of 30–50 other HIV patients and talks about their personal experiences and demonstrates how to give an injection. Those have been remarkably successful.
"There is no question that this product works. There is no question that viral resistance is a growing problem, and there are an increasing number of treatment-experienced patients who have virus resistance to conventional therapy. We are convinced Fuzeon will ultimately be a backbone therapy for HIV."
That's not to say that building a fusion inhibitor franchise will be easy. In January, Roche and Trimeris announced they were halting the development of T-1249, their next generation fusion inhibitor. At the time, some commentators said the halt was a response to the sales performance of Fuzeon. Not so, says Abercrombie.
T-1249 is biologically different from Fuzeon, and behaves differently in manufacturing. "The truth is simply that we are facing technological hurdles on the mode of administration," Abercrombie says. "We recognized that getting an injection at the right frequency in a dosage form that will be convenient for patients is a huge technological hurdle with proteins of this type—and that is the sole reason.
"In that same announcement," he continues, "we explained—and people seem to forget this—that we signed an extension of our ongoing research collaboration with Trimeris," says Abercrombie. "I think that alone demonstrates our long-term commitment to fusion inhibition."
Commercializing a single innovative drug is one thing. Guaranteeing an adequate supply of truly innovative drugs is another. Roche spent CHF 4.8 billion on research and development in 2003, about 15 percent of sales. It concluded 30 research alliances in 2003 alone. But what the company is unlikely to do is buy a pipeline by acquiring another company. Roche's culture includes a deep distrust of mergers.
"The model of going in and trying to impose your culture on other companies has been proven wrong and destroys value," says Lee Babiss, vice-president of preclinical research and development. "You can look at the data, and it's very consistent in every company that's done major mergers that there's going to be a three-year gap in pipeline productivity. In the short term you're going to be doing great because you're bringing two product lines together. But a few years down the line that gap is going to progress to the right and where you should have been launching for the next three years there's nothing there. And that puts you in a vicious cycle of having to do more and more alliances and acquisitions to maintain the revenues you need to keep that engine going."
Abercrombie agrees: "Success in this business is not about size, it's about getting better," he says. "We are committed to growing organically. We are committed to remaining independent. And I think not only has our own financial performance success proven that our strategy is right, the way we deal with our partner companies also proves that it is right."
At a time when many companies are struggling with the task of integrating smaller biotechs and pharma companies into their operations, Roche has pursued what it calls a "hub and spoke" approach. It owns majority stakes in both Genentech and Japan's Chugai. But it has left both to run independently, instead creating opt-in arrangements that control how Roche gains access to its partners' products.
"We did not gobble up and merge with Genentech," says Abercrombie. "We recognized that the best way to optimize Genentech is to let them stay independent, the size they are, with their great track record."
The system creates some interesting situations: Roche in the United States competes with Genentech's Herceptin and MabThera (as it will with Genentech's upcoming Avastin (bevacizumab) for metastatic colorectal cancer. Outside the United States, Roche co-develops and markets the products.
Only time will tell whether hub-and-spoke management is really superior to integration, but Roche is not alone in thinking that scale and independence are powerful factors in preserving innovation. The Harvard economist Clayton Christensen, in The Innovator's Dilemma (1997), documented some ways in which small companies were freer to pursue "disruptive technologies" than their larger counterparts.
The real question is how effectively Roche can make use of the opportunities that hub-and-spoke creates. In preparing for the launch of Avastin (bevacizumab), for example, Roche in Europe took on part of the responsibility for manufacturing Herceptin, to free up Genentech's capacity for the new drug—a move that weaves together the interests of both companies on multiple levels.
If Roche can extend that kind of thinking, and spread it over a network of additional partners, hub-and-spoke could become an important model for the industry.
Twin Pillars
For Lee Babiss, one of the principal attractions of working at Roche was its "twin pillar" philosophy of pairing drugs and diagnostics. "I was recruited to Roche by Jonathan Knowles, who is president of research. Jonathan and I had worked together at Glaxo, and he had been actively recruiting me for about a year prior. One reason I joined is the twin pillar concept. I worked with Jonathan to create a whole genetic and genomic strategy at Glaxo, which eventually led to the creation of a new division of genetics.
"One of the things that was lacking in that strategy was the ability to take the concept and create products from it. Roche is the largest diagnostics company in the world and had the full capability of turning those biomarkers into assays that could then make it to the market."
The goal is what Babiss calls "personalized medicine"—a term that for many at Roche has come to replace "individualized medicine" and "customized medicine." In the Roche world view: "Personalized medicines can't stand alone independent of a diagnostic," Babiss explains. "Personalized medicine is the mantra for our pharma side of the company, and personalized healthcare becomes the mantra for the Rx and Dx units.
"Personalized healthcare comes from the use of diagnostics to help us best apply the personalized medicines. It is based on the identification of biomarkers—anything from substances derived from tumor tissue or patterns of proteins in organs to something as simple as glucose in the blood.
"What you have to do is take that knowledge to see if you can get a better understanding of the disease and how your drug works. We have invested in programs predominantly in oncology and autoimmunity. It's been proven to work in oncology; certainly the example that gets cited is Herceptin.
"We also have some examples in the great work that's been done in the area of viral diseases by our diagnostics colleagues—who are studying viral resistance emerges by actually genotyping the variants that emerge during treatment."
It's not that every product will need to come with a molecular-level test, Babiss explains. For a product like Tamiflu (oseltamivir) for influenza, with its low cost and low side-effect profile, the presence of flu-like symptoms might well be enough. But chronic diseases—such as diabetes, a major focus of Roche Diagnostics—are a different story.
"In type 2 diabetes, you have to be on these drugs for a very extended time, and the response rate is 30–40 percent," Babiss explains. "So we're focusing heavily now on trying to understand what distinguishes responders from nonresponders, from understanding the molecular basis of the disease. We've got some really good progress with that in working with deCode Genetics, the Icelandic company, on the genetic front, as well as doing proteomics and other sorts of technologies by gaining access to human tissues to identify biomarkers.
"As we look at our portfolio in metabolics, we have an insulin sensitizer that's entering Phase III. That's one in which we'll actually use biomarkers to see if we can direct the drug to the most susceptible portion of diabetics."
Babiss says the challenge is not just scientific, but organizational. "It is easy to create a very clear group with clear lines of reporting," he says. "But sometimes what's easy to do is not what's best to do. So we've chosen not to go that path, and we have a highly matrixed organization. All of the activities that support integrated healthcare and personalized medicine are supervised by a team composed of the head of diagnostics the head of pharma, the head of pharma research, myself, and then the person who has full-time accountability for all of this. That's Tom Metcalfe, who comes to us from diagnostics and heads the Roche Biomarker program."
In the long run, to Babiss, the real advantage of the twin pillars approach is the deep understanding it provides of disease—understanding that can lead to far more effective utilization of products.
"We're learning how to look at a primary indication for a drug and get it to market, then see its potential in a broader set of disease indications," he says. "If you want to talk about the greatest way to create value in a pipeline, that's the way to do it. So I'm very excited about our autoimmune and inflammatory drug pipeline, because the potential is enormous.
"One program we have running is for asthma—basically an integrin inhibitor, which prevents infiltration of immune cells into various tissues. It also has implications that range from asthma and emphysema to rheumatoid arthritis to inflammatory bowel disease and multiple sclerosis—an endless number of disease indications. When you are able to take a drug that's on the market and find new indications for it that's a windfall. You've saved essentially all the money it cost to bring the drug to market, and you can generate a huge business opportunity."
An Exceptional Year
Roche's eye is on the long term, but in the short run, 2003 was an exceptional year for the company.
Sales for the entire group were up 6 percent, from CHF 29.5 billion to CHF 31.2 billion. Operating profits before exceptional items more than tripled from CHF 1.3 billion to CHF 5.6 billion. The results were even more striking when only ongoing businesses were considered, and the vitamin and fine-chemical businesses were factored out. On that basis, sales were up 11 percent, from CHF 26.1 billion to CHF 29 billion. Operating profits increased by 28 percent, from CHF 4.5 billion to CHF 5.8 billion, and the company went from a net loss of a bit more than CHF 1 billion in 2002 to a net income of almost 3.3 billion in 2003—11.4 percent of sales.
Prescription pharmaceuticals accounted for sales of CHF 19.8 billion—slightly more than two-thirds of sales were from ongoing businesses. Rx drug sales rose by 23 percent on a local-currency basis in 2003—and even when the effect of the integration of Chugai into Roche's balance sheet is factored out, prescription pharmaceuticals outpaced the market.
The leading Roche drugs worldwide for 2003 (see also "Top-Selling Products," page 76):
MabThera/Rituxan (rituximab), a monoclonal antibody therapy for non-Hodgkin's lymphoma, was co-developed with Genentech (and sold by Genentech in the United States). Sales rose 34 percent to CHF 2.8 billion.
NeoRecormon (epoetin beta), a treatment for anemia, marketed only in the EU, saw sales rise 30 percent to CHF 1.2 billion, partly because European authorities approved a new regimen for dialysis patients with stable hemoglobin levels. When results of Chugai's epoetin beta product, Epogin, are factored in, epoetin accounted for sales of almost CHF 2.1 billion for Roche.
Rocephin (ceftriaxone), an antibiotic, is facing generic competition in Europe and will go off patent in the United States in 2005. Strong US sales, buoyed by an early season for respiratory diseases, maintained sales at CHF 1.4 billion.
CellCept (mycophenolate mofetil), an immunosuppressant used in organ transplantation had sales of CHF 1.3 billion, an increase of 27 percent. Roche presented data that the product, unlike some other immunosuppressants, does not increase the risk of cancer in transplant patients.
Herceptin (trastuzumab), for the treatment of metastatic breast cancer, is another product co-developed with Genentech (and marketed by Genentech in the United States). Sales in 2003 rose 27 percent to CHF 1.2 billion. New data point to the use of the drug in combination therapies, and European approval of Herceptin in combination with Aventis' Taxotere is expected this year.
Pegasys and Copegus (peginterferon alfa-2a + ribavirin), a combination therapy for hepatitis C, just passed its one-year anniversary on the US market and is performing strongly, passing Schering-Plough's PegIntron as the market leader. Sales for 2003 were CHF 942 million.
Not at the top of the list, but performing strongly this year was Tamiflu (oseltamivir), for the prevention and treatment of influenza A and B. An unusually hard flu season produced sales of CHF 431 million, almost double 2002's figure.
Challenges remain—perhaps not least, the challenge to remain independent. Novartis, the other major Swiss pharma company, has made no secret of its interest in merging with Roche. In 2001, it purchased 20 percent of Roche's stock. The stake rose to more than 30 percent, and this winter, Novartis took its holding to 33.3 percent—just below the level that under Swiss law automatically triggers a formal bid.
A majority of Roche's voting stock is still owned by the Oeri and Hoffman families. (They own a much smaller share of total share equity, thanks to the company's dual share structure.) Family members have so far been fiercely attached to the idea of independence. But there is no guarantee that situation will last forever—and the fallout of Sanofi's bid for Aventis demonstrated some of the pressures, including the interests of national governments, that may be brought to bear on the company in the future.
But that, if it comes, is tomorrow's problem. For now, says Abercrombie, the task is clear.
"You cannot sit back and rest," he says. "Our job is to constantly seek new and better ways of treating patients. If you have areas of strength, like oncology, hepatitis, and transplant, where you have a certain knowledge of customers, you have an expertise, that's where your focus should be in addition to looking for new areas of opportunity.
"The beauty of this market is that patients and physicians recognize when new therapies work. It's a market that rewards success and rewards innovation."
WebcastsFree Registration
How Digital Medicine Can Pinpoint Dosing Regimens to Optimize Drug Efficacy and Safety


text:
UPDATE: Couple Attacked While Riding Bicycles Comment, Allege Hate Crime
Long Beach couple Jamie Jarvis and Meg Taylor were attacked Saturday evening near Broadway and Esperanza Ave. while riding their bicycles.
Long Beach couple Jamie Jarvis and Meg Taylor were attacked Saturday evening near Broadway and Esperanza Ave. while riding their bicycles.
Do you know what's hanging above the entrance at Joe Jost's? How many lightbulbs does Ace Hardware have in its ceiling? These are all questions you can find the answer to by participating in the 2nd Annual Discover East Long Beach Treasure Hunt this Saturday, October 4.
Be sure to grab your seats, and your costumes, for The Lalas' Halloween Show at The Federal Bar in Long Beach on Friday, October 17 at 8:00PM
Meet Vanilla. Vanilla is a 10-year-old medium-hair Siamese mix with the face of a Bowery Boy toughie. After several hundred dollars worth of vet care, Vanilla's been neutered, rid of fleas and healed of everything healable. Vanilla is your basic lap cat, affectionate and purry. Vanilla is also FIV-positive.
The Long Beach Public Library (LBPL) has alleviated the pressures that face both the impatient and the introverted bookie while letting library staff focus on the patrons who desire more quality interaction by way of their new self-checkout stations.
In anticipation of bringing the musical version Big Fish to the Carpenter Center later this month, Musical Theatre West (MTW) announced today it will be screening the Tim Burton movie of the same name on October 16 for free.
You know that inconspicuously inviting tent you probably saw at a farmers market in Long Beach? That's the Pop-Up Coffee Shop, also called Wide Eyes Open Palms, an independently owned, environmentally sustainable local business that truly adds to Long Beach's reputation as a great place to eat, drink coffee and support the eco-friendly use of fresh ingredients.
A man who stole a bike from a Cal State Long Beach student and evaded police earlier this year was sentenced last week, CSULB police said Friday.


text:
More Videos...
1974 Buick Apollo for sale
1974 Buick Apollo for sale in great condition
Buick Apollo ZZ502
Buick Apollo zz502 Marjamaki racing Lempaala
Buick - History Documentary (1995)
This video is a wonderfully-done documentary, written and produced by
Michael Rose, on the history of Buick as presented in 1995 from the History
Channel's archive. Here is Michael's description of the video verbatim:
"No one would have believed that the tinkering of a plumber would turn into
the foundation of the world's largest corporation. But it did. David Dunbar
Buick invented a process to adhere porcelain to tubs and other bathroom
fixtures. But the Scottish immigrant dreamed of making a mark out of the
bathroom, and set to work building a car. By 1900, he enlisted the aid of
another inventor, Walter Marr, and they built their first vehicle. Their
invention attracted the attention of one of Michigan's wealthiest men,
William Crapo Durant, the president of the world's largest buggy-building
business. As soon as he drove one of Buick's early creations, Durant
realized that the days of the horse and buggy were over. He teamed up with
Buick, and the two went on to make history. By the thirties, Buicks were
regarded as some of the finest cars ever made. From the first Buicks
through the birth of General Motors and into history, this is the
compelling story of the partnership that eventually became the basis for
the largest company in the world."
1974 Buick Apollo (Bad to the Bone)
Finally got the Buick rolling again after some ignition problems, did the
oil change and put some fresh gas and she cranked right up, did alot of
interior work and some modifications to the interior, any questions or
comments just let me know, wanna see a video of something let me know, hope
to get some more videos rolling again after schools out and when i get some
more money lol
1987 Buick Grand National (Regal T-Type Turbo) Start Up, Exhaust, and In Depth Review
**I made an editing error at the beginning. Thanks a bunch to Streetside
Classics of Charlotte, NC for allowing me to film this video!
Hello and welcome to Saabkyle04! YouTube's largest collection of automotive
variety! In today's video, we will take an up close and personal in depth
look at the understated muscle car of the late 80s, the Buick Grand
National, this one specifically the Regal T-Type. The GN and the T-Type are
identical except for badging and interior trim. It wasn't until you
stepped it on up to the GNX did you get the truly different package (which
I will explain in the video). The GN is arguably the most menacing looking
buick of all time with it's black monochrome paint scheme and turbo charged 3.8 V6 pumping out amazing
performance numbers for the time period, even today! A unique experience
to be able to check out one of these beasts. During this presentation, we
will take a 1st person look at what the vehicle is all about beginning with
the start up, performance data, fuel economy, the occasional track data,
and build quality. Also, I will teach you how to use most of the interior
and exterior features in a detailed fashion, that before, you could only
get from going to a dealership yourself! Throughout the video, I will
highlight key styling and unique differences about the vehicle, any
available options, and of course it would not be an enthusiast car video
without the good ole engine portion with rev and Exhaust note with interior and exterior
perspectives. A thorough tour/review of this car designed to give others a
greater overall appreciation of the vehicle.
FOR MORE INFORMATION ABOUT THE CHANNEL SEE BELOW: In this channel you will
find in depth reviews/tour of automobiles from all over the world,
presented in a more detailed fashion than ever before. Basically, this
gives the viewer the chance to view the most detailed 1st person look you
can get without going to an actual dealer yourself! Every video is
consistent in the way I present so viewers know what to expect in my
presentations. I treat every vehicle with the same respect whether a 1960
Chevrolet Impala SS or the 2012 Lamborghini Aventador. I film all types of
vehicles from past, present, and future while broadening the knowledge of
the automotive enthusiast. You will see everything from vintage, brand new,
exotic, mainstream, old, etc. I am very proud of this channel and have
built it up from amateur videos years ago to what you see today. I wanted
to share my love for the automotive world with the rest of the world. Be
sure to explore the massive video variety, have fun and enjoy The Driver's
Seat of YouTube!
1973 buick apollo
buick 350 2 bbl engine in it for now looking for a 70 buick 350 4 bbl with
315 hp to put in it. Feel free to coment
Big Block Buick 462 going into a 73 Buick Apollo
Here is the buick 462 thats going in a 73 buick apollo. 73 455 block bored
.30 over, speed pro .30 over hypereutectic pistons with 4 valve reliefs and
coated skirts, about 9.5 to 1 comp. ta 310 cam, stock 73 heads slightly
milled with stock valves, new springs and bowl ported. Crank and rods are
original. Can't wait! should be fun! A big thanks again to Rick at HBR
Competition Engines.
1974 Buick Apollo (Nova look a like) overview (open headers)
heres my other toy lol this is a 1974 Buick Apollo, a cousin to the Chevy
Nova. im restoring it and rebuilding it to be a street legal drag car.
its got a 72' chevy 350 engine, custom 350 turbo trans, 3 speed auto, 10 bolt rear. im gonna
be paintin it purple, like deep lol with silver ss stripes and yellow
outlining (kinda like the Vikings football team colors lol) so yeah, hope
yall like it, i know i do
09 cruise to woods burn out
My 1974 buick apollo in stratford iowa doing a burn out as it leaves town.
If you haven't been to cruise to the woods yet you have to go it's one of
the largest car shows in iowa and one last ones of the year in the mid
west, great people , cars, and food
Chevy Chevelle Vs Buick Apollo Quarter Mile Gateway Motorsports Park
Be sure to check us out on Facebook at:
I thought you might like a look at this two GM classics going head to head
in the quarter mile. We have the always cool Chevelle Chevelle, up against
the rarely seen, Buick Apollo. As you can see, both cars are plenty quick.
This was filmed at Gateway Motorsports Park, just outside of St Louis, MO.
Slow Burn by Kevin MacLeod is licensed under a CC Attribution 3.0.
Permissions beyond the scope of this license are available at
2013 Buick Encore | New Car Review | on Everyman Driver
2013 Buick Encore FWD Review on Everyman Driver with Dave Erickson. Please
visit http://www.everymandriver.com/
Support the EMD Team with a $20 Gas Card via Paypal:
Subscribe now to receive new Everyman Driver videos in your feed:
Subscribe now to receive new Everywoman Driver videos in your feed:
Subscribe now to receive new Everyman Driver News Channel videos in your
feed: http://tinyurl.com/mud34b9
For more free car review videos from the Everywoman Driver visit:
Like Everyman Driver on Facebook:
Follow Everyman Driver on Twitter:
Dave Erickson is a Multi-Media Producer, Freelance Reporter, Videographer,
Podcaster and Host. Before Everyman Driver, Dave spent 15 years working as
a TV News Anchor and Reporter. Learn more at
Buick 455 Stage 1 (1-2)
1973 Buick Apollo
1973 Buick apollo thats gonna get an olds 462 that was going into my 75
olds omega. The olds is now sold so I guess this will be my new street car
project. Its a rolling chassis now but the body is solid and rust free.
buick apollo gsx burnout
the story is . i found this in a old mans barn and it was sitting in there
for about 12 years until i found it. at first i didnt know what it was ,
after a few days of research i found out there were only 1000 or so buick
apollos with this gsx package , it came with a buick 350 but when the man
got it he put a 455 big block in it and did some work to the engine it
puts out about 515 torque and stock horsepower is 350 , but it
has high performance cam aluminum intake , 600 holly four barrel carb ,
shift kit , and other stuff so maybe close to 400hp . this video was taken
before it was tuned on lol still with alittle old gas and old plugs and
Lamborghini Huracan Driving Event and 60-130 MPH Testing
Ford GT McLaren MP4-12C Lamborghini Gallardo Super Trofeo Stradale Photo Gallery
GoPro Winner for August 2014 is Steve with a 2002 Dodge Dakota
Lamborghini Huracan vs Porsche 911 Turbo S PDK Racing
Which car is faster?
Similar 1/4 mile timeslips to browse:
1973 Buick Apollo : 8.700 @ 155.870
Thomas Fuchs, Engine: 565 Chevrolet, Tires: Goodyear
1974 Buick Apollo : 11.766 @ 111.790
bill macke, Engine: 72 chevy 400 smallblock,
©2014 DragTimes - Disclaimer


text:
Tv stand
Black Glass (BS6206A) tv stand in immaculate condition. 48cm x 38cm x 61 cm ( h x d x w).
Black Glass (BS6206A) tv stand in immaculate condition. 48cm x 38cm x 61 cm ( h x d x w).
I have a double blow up mattress and pump for sale, only used twice for children. Asking £20 Ono
Excellent condition fully working order
Beautiful pink Marilyn Monroe canvas
high quality lightweight aluminum frame folding trolley
Very nice double Sofa Bed!!!
Leather Sofa Extra space to rest your legs. YOu will love it.
Glass tv or hifi unit
Two camels two zebra small tables one baby giraffe the big giraffe has one ear that's broken
1 grey chair and 1 black soft chair Depth: 47 cm Height: 76 cm Width: 45 cm Buyer to collect from Stoddart House, Meadow Rd. SW8 1NB Contact by call/text: 07443127452 If you can see this add means the chairs are still available Than
BEAUTIFUL TABLE LIGHT AND STABLE GLASS TOP GREY FRAME L 55cm / 21.7" x W 55cm/ 21.7" H 42cm / 16.6" Buyer to collect from Stoddart House, Meadow Road SW8 1NB To arrange pick up call/text: 07443127452 Thank you
HINARI STEAM SUPREME IDEALLY STEAMS VEGETABLES FISH CHICKEN NOT NEW BUT STILL IN A GREAT WORKING CONDITION Buyer to collect from Stoddart House, corner of Meadow Rd/Claylands Rd. SW8 1NB To arrange pick up call/text: 07443127452 If you
I have for sale this cabinet, in white, with a mirrored front. There are glass shelves inside. Size is 30 x 21 x 179 cm pick up from near East Dulwich station.
NEW SECURITY SPIKES 2 pack - £10 4 m pack 8 x 500 mm strips. Grey colour Security spikes allow you to discreetly protect your property from intruders and unwanted animals. Easy to use - the 500mm x 45mm strips can be screwed, nailed or glued PO
Antique for stool in great condition With new straps no scratches or tears £20
We are moving out on Monday and we can't take these furnitures with us. I suggest £60 for the all lot but items can be purchased separately at lower price. Items: - Small white narrow shelves - Two white square shelves - Small phone shelves -
Good condition. Quite short in height. Dimensions: Depth: 38 cm Height: 74 cm Width: 43 cm Collection only on Sunday evening (6 pm onwards), Monday afternoon (midday - 4pm) and Tuesday morning (until midday) I'm moving abroad on Wednesday
2 ikea table for sale in great condition 1 coffee table in oak 1 side table in birch In great condition £15 for the both
Good condition. Measurement: Depth: 30 cm Width: 60 cm Height: 60 cm Collection only on Sunday evening (6 pm onwards), Monday afternoon (midday - 4pm) and Tuesday morning (until midday) I'm moving abroad on Wednesday, so I've got to sell
Selling a range of furniture / kitchen appliances all at excellent condition. (all items are less than 1 year old) Items can also be sold individually at the prices noted below. 1 IKEA MALM Desk + desk lamp - £30 1 IKEA GALANT white des
Sealed new
Argos corner table for sale. used and in good condition. if interested pls contact. collection from south croydon. Regards
Good condition. Measurement: Depth: 23 cm Width: 40 cm Height: 180 cm Collection only on Sunday evening and Monday afternoon.
2 ikea stool in great condition been in storage White and Crome
New 2 Seat Chesterfield Sofa. 2 Seat Sofa Size (W)160, (D)85, (H)75 Selling For Only £500. In Colour Wine. I Had The Sofa Hand Made By Chesterfields. Sofa's Cost Over £1,500 To Be Maid. Pick Up Only. Near Har
New 3 Seat Chesterfield Sofa. 3 Seat Sofa Size (W)203, (D)85, (H)75 Selling For Only £800. In Colour Wine. I Had The Sofa Hand Made By Chesterfields. Sofa Cost £1,800 To Be Maid. Pick Up Only. Near Harlesden
New In Box. Never Open. Never Used. Vax Power Midi 2. 2000 Watts, HEPA Filtration. 2 Year Guarantee. Selling For Only £40. Cost £79.99-£99.99 In Store's. Pick Up Only. Near Harlesden Tube Statio


text:
I was at the golf shop taking some swings. But as many of you and many mothers know...I am always on the hunt. Today was no different. Roxetta was a fucking hottie and I set my sights on a hole in one. I was so horny today that I barely let her finish the blowjob. She had a super sexy body and I just had to have her. I gotta run now. Gonna meet with her again in a bit...
"Still Got It"
"Big Booty Mama"
"Wicked Tease"
"Heart Shaped Booty"
"Pink And Perky"
"Milf Muffin"
"Summer Loving"
"Fast Cars Easy Pussy"
"Panty Releaser"
"Soccer Milf"


text:
Alex Salmond resigns: Scottish First Minister steps down after No vote
Alex Salmond today dramatically announced he is resigning as Scottish First Minister hours after the country rejected independence.
Baby has nose bitten off by Staffordshire Bull Terrier in north London
A baby girl had part of her nose bitten off by a dog in north London.
Boris Johnson launches bid to give London greater powers
Boris Johnson today signalled a major push for London to seize greater power over its own future in the wake of Scotland's independence referendum.
Sign our petition for a fair deal on overcrowded trains
Published: 30 January 2007
A petition to the Prime Minister calling for an end to "intolerable" overcrowding on commuter trains is going up on the Downing Street website.
Click here to sign the petition
The petition was drawn up by Brian Cooke, the chairman of passenger group London Travel-Watch, which is supporting the Evening Standard's A Seat For Every Commuter campaign. It is hoped the petition will increase the pressure on the Government to provide more funding for the train operating companies so that they can run longer trains and more frequent services.
Figures published yesterday showed how overcrowding is becoming the biggest bugbear for commuters.
Levels of satisfaction about train seat availability among passengers has fallen on eight of the 11 rail franchises used by London commuters.
The Standard campaign also has the backing of almost 100 MPs.
Dozens of Conservative and Liberal Democrat MPs, as well as growing numbers of Labour politicians, have signed a Commons motion tabled by shadow transport secretary Chris Grayling.
MPs voiced the anger of thousandsof commuters during a parliamentary debate last week on First Great Western's poor service. They told how they have been flooded with letters of complaint from constituents.
The problems are being suffered by commuters from across London and the South-East. Esher and Walton Conservative MP Ian Taylor, who will be the ninetyfourth MP to sign the Commons motion, praised the Standard, saying: "Keep up the campaign."
He added: "Trains get very crowded at Surbiton.
"We need more trains and longer trains but that requires us to have more platforms at Waterloo and investment at Clapham Junction to allow this to happen."
The Early Day Motion expresses concern at comments by Department for Transport rail chief Dr Mike Mitchell, who said it was "not unacceptable" for commuters to have to expect to stand during peak hours. Calling for a review of the rail industry, the motion also stresses that, following fare increases, passengers are having to pay more to travel in increasingly uncomfortable conditions.
Mr Grayling said today: "The reality for today's commuters is paying through the nose to travel like sardines.
"I hope commuters will voice their anger at ministers, both directly by supporting campaigns like the Standard's - and in the ballot box."
Anyone who wants to sign the online petition should CLICK HERE and add their name to the list.
Top stories in News
News in Pictures
Top stories in News
News in Pictures
- Man is first person to buy iPhone 6 in Australian city - but immediately drops it on live TV
- Hackney council removes 'unacceptable' posters telling women which side of the road they should walk on
- Trocadero to be turned into seven-screen arthouse cinema
- Brothers groomed teenage girls in care home and threatened them with torture
- Watch heroic teenager rugby tackle violent thug who assaulted two female police officers
- EXCLUSIVE: Mayor's new £48m cycle superhighway would have to be removed after just one year to make way for supersewer construction
- Top Portuguese academic slams the English as 'unrestrained wild beasts'
- Sacked: Estate agent caught on spy camera stealing Galaxy chocolate bar from flat
- London New Year's Eve fireworks display: Revellers to be charged £10 a ticket to attend event
- Laughs all round as police officer tries to halt cyclist for riding on bike path
- Watch heroic teenager rugby tackle violent thug who assaulted two female police officers
- Watch pedestrian race Tube train from Mansion House to Cannon Street - then hop back on to the same train
- Brothers groomed teenage girls in care home and threatened them with torture
- Man is first person to buy iPhone 6 in Australian city - but immediately drops it on live TV
- Model shocked and angered as commuters 'stood and watched' while smartly dressed man hurled racist abuse at her on the Tube
My Fit Lifestyle: week 12 update
Niki Chesworth and Laura Varnam discover portion control on Tesco's new My Fit Lifestyle programme
Book tickets for Kooza now!
KOOZA is an electrifying return to the origins of Cirque du Soleil combining two circus traditions - acrobatic performance and the art of clowning.
Street Ahead
London Fashion Week kicks off this Friday, and this season you're all invited, thanks to a eight-day fashion showcase taking place on Oxford Street for a front-row seat.
All that glitters
Style magpies are in for a treat next season as the fashion gods dig deep for gold. From sweatshirts to shorts.
A city where you want to step outside and inhale
Savour everything from Banksy's art to Brunel's splendid engineering and plentiful open spaces in buzzing Bristol, reports Sarah Baxter
Watch our latest #FASHIONHAPPY videos
Shop London follows the recent user video competition and finds out what makes people feel #FASHIONHAPPY
Made of London Series
London Pride together with Evening Standard celebrating the people of London that make us proud
A Brave New Season
Brogues vs trainers. The great winter coat debate. Shape-shifting silhouette PLUS win the edit
BFI London Film Festival 2014
Your essential guide to the BFI London Film Festival, which runs from October 8-19 2014
Life is a catwalk
It's almost London Fashion Week, which means new trends aplenty for style buffs. Take your lead from the best-dressed fashion editors in town this fall.
Reader Offers email A fantastic selection of
offers, giveaways and


text:
This site is a public resource celebrating The Who. It is not sponsored or formally affiliated in any other way with The Who or the band's members, management or other representatives. In accordance with laws regarding copyright and other forms of intellectual property, material excerpted and posted on this site is strictly for nonprofit research, scholarship & commentary about The Who, its members and their activities.
I'm One
Success Story
Guitar and Pen
Goin' Mobile
My Generation
Article Archive
Who Associates
See Me, Feel Me
Photo Archive
Irish Jack's Webpage
Who Theater
Join Together
Odds & Sods
Chat Room
The Seeker
A Legal Matter
A Word about Copyrights
Privacy Policy
My title
Who Are You
Welcome Anonymous
Latest: kenpark
New Today: 0
New Yesterday: 0
Overall: 845
People Online:
Members: 0
Visitors: 23
Bots: 2
Total: 25
Who Is Where:
01: OurContent
02: Home
03: OurContent
04: WeblinksPro
05: Home
06: Pro News
07: Home
08: Photo Gallery
09: Home
10: Home
11: SearchResults
12: WeblinksPro
13: Home
14: Discography
15: Home
16: Home
17: Home
18: Home
19: Home
20: Home
21: Home
22: Home
23: Home
01: Yahoo > Home
02: Google > Pro News
Staff Online:
No staff members are online!


text:
Watch Featured Movies
Dom zly: The story takes place in two parallel time planes. The first plot follows the events of one autumn night in 1978. Edward Srodon, a zootechnician, makes an accidental stopover in a farmhouse of Dziabas family in the remote area of Bieszczady Mountains. He stays for the night. The initial distrust between the guest and his hosts is quickly dispelled with moonshine and turns into a camaraderie, intimacy and even friendship. A plan of making a joint business arises, as well as passion and lust, which lead to a surprising and tragic consequences... Second plot is set on a winter day, during the Martial Law in Poland. An investigating team of Milicja Obywatelska (People's Militia) is visiting the crime scene. Lieutenant Mroz is trying to solve the multiple murder case from four years ago. The tool he has to his disposal is the reconstruction of events with help of the chief suspect, Srodon.
|September 16, 2009
|105 mins
|Crime Drama Thriller
|Wojciech Smarzowski
|Bartlomiej Topa Bartosz Zukowski Jerzy Rogalski Kinga Preis Lech Dyblik Maciej Maciejewski Marian Dziedziel Mariusz Jakus Robert Wabich Robert Wieckiewicz Slawomir Orzechowski
Dom zly Links
|Version 1
|2863 views
|Version 2
|12893 views
|Version 3
|14845 views
|Version 4
|179 views
|Report Broken
|Version 5
|4229 views
|Report Broken
|Version 6
|410 views
|Report Broken
|Version 7
|115 views
|Report Broken
|= Low Quality
|= Medium Quality
|= High Quality
|How do I watch these?
Similar to Dom zly
Dom zly Tags
Dom zly Comments
|Posted by rethbell 2 years, 1 month ago
one of the best movie to came out of poland recently, very realistic, usualy polish mainstream is a gangster comedy, or just silly stuff, this came as a huge suprise. really dark and twisted. like a tag line say" truth? there is no such a thing":):) 9/10 from me:) highly recomended
|Posted by 22blanche 2 years, 1 month ago
High calibre thriller. Horrifying and grim in equal measures. Stick with it despite the dodgy subtitles, it does all make sense in the end. Worth a watch. 4 stars
|Posted by urizen 2 years, 1 month ago
5/5 awesome movie!
|Posted by fug300 2 years, 2 months ago
wow,this was off the hook,like one of the other comments,stay with it the ending is wild..............
|Posted by arwen44 2 years, 2 months ago
Really liked it. Can be confusing but if you stay with it, it does make sense. Quite a mystery, you just don't know who is telling the truth.
|Posted by Precious1 2 years, 2 months ago
Loved this, but then I like art movies that linger on scenes making you think and wonder why...great twist, just did not get the last scene when you know who is lying on the ground with a knife in his chest. Who did that? dunno. 8/10
|Posted by stabiliziert 2 years, 2 months ago
Ranking 8/10, not a movie for the unintelligent. This is how Poland looked like in the communist era, drunken cops(milicja) sleeping in their cars behind barns or an empty alley. 100% solved crimes(innocent were forced to admit to crimes they didnt do).
|Posted by zapater 2 years, 2 months ago
Is this a comedy or an allegorical portrait of the dark communist era in Poland?? Truth can't be found or everybody is too drunk to even think straight??curious and different movie but unusually unpleasant...3/5.
|Posted by Olenka_26l 2 years, 2 months ago
Ale nudny film.... :(
Post a Comment
Dom zly Reviews
Join the site, its free!
I can't watch movies! Help!
Site Updates and News
Support the Site
Latest Comments
deerwatcher65 : i forgot just how great this movie is,and llfe like.great acting 5/5
philingme : I really like this show. Its a good watch. Waiting for season 2.
mc777 : why does jax want to kill juice? is this because of his big mouth?
Ruby3 : Brilliant! With hundreds of crime shows out there, this one really caught my att ...
Suzicueball : So glad I gave this move a chance. I totally thought I'd hate it because it wasn ...
Moonlightsilver : This one didn't do much for me. I didn't find the stories as captivating as some ...
haaani : so there will be another movie, cant wait for it.
A_CERI : Please can we have some double eliminations, as I hate to see so many human canv ...


text: lipstick, make up, nailpolish, nars, pink Added: Nov. 3, 2011 | Image size: 500 x 375 px | More from: hollywoodxo.tumblr.com | Source: linkNo comments Please log in or sign up to post a comment. add to set Views: 1157 Likes (**Who?): 1 Comments: 0 Tagged with :lipstick 6734make up 16739nailpolish 1600nars 471pink 104049Log in or Sign upLog In" or Sign Up


text:
Breaching the Wall
December 1, 2011|
Editor's choice in immunology
December 1, 2011|
Editor's choice in immunology
December 1, 2011|
Tagging antibodies with rare earth metals instead of fluorescent molecules turns a veteran technique into a high-throughput powerhouse.
November 2, 2011|
Meet the species whose DNA has recently been sequenced.
October 26, 2011|
The last rhinoceros left in Vietnam was found killed, its horn sawed off, most likely by poachers.
October 21, 2011|
Inadequate poultry immunization programs may cause higher mutations rates in the bird flu virus, rendering the vaccine ineffective and increasing the threat of cross-species transmission.
October 3, 2011|
The Nobel Assembly announced today that three researchers in the field of immunology will share the 2011 Prize in Physiology or Medicine.
October 3, 2011|
The Nobel Assembly reveals three winners of this year's prize in Physiology of Medicine.
October 1, 2011|
Reversing catastrophic threats to our planet's biodiversity is not optional: our lives depend on it.
October 1, 2011|
Ecosystems are failing and extinction rates are soaring. Thomas E. Lovejoy and Edward O. Wilson weigh in on why cataloging existing species, discovering new ones, and maintaining a balanced and diverse global ecosystem are critical for ensuring a habitable environment for all.
September 19, 2011|
New molecular analyses yield clues to the success of a 2009 human HIV vaccine study.


text:
Marco Reus scored a hat-trick as Dortmund came from behind to beat 10-man Stuttgart 3-2 in Jurgen Klopp's 300th Bundesliga game at the helm.
The result ensured Dortmund strengthed the credentials for a second-placed finish, with Klopp's men now one point ahead of rivals Schalke, and ensured the hosts remain in the mire.
The hosts took a deserved lead within 10 minutes, when Christian Gentner took advantage of a defensive error to curl home, before Martin Harnik doubled their advantage by rounding off a great run from Ibrahima Traore.
The visitors pulled a goal back 15 minutes before the break through Reus' cool finish, and were nearly level just after the interval when Robert Lewandowski's strike came crashing off the post.
Stuttgart were then reduced to 10 men midway through the second half, when Georg Niedermeier brought down Lewandowski in the area and Reus converting the resulting spot-kick.
Reus was then on hand to complete the comeback with a well-worked third, as his deflected finish from the edge of the area found the back of the net.
Klopp dismissed accusations that his side were distracted by their UEFA Champions League exploits after being held by Schalke last week, but they started slowly against a spirited Stuttgart side.
And they were made to pay for a cagey opening after 10 minutes, when Gentner pounced on Oliver Kirch's poor back pass on the edge of the area, before curling a smart finish past Roman Weidenfeller.
The goal gave Dortmund a little more urgency, with Kevin Grosskreutz forcing a good save from Sven Ulreich five minutes later.
But the home side's lead was extended after 19 minutes, when Traore powered through on the right hand side before cutting inside to Harnik, who was left with a simple finish from close range.
The visitors pulled one back on the half-hour mark, as a perfectly weighted ball from Jonas Hofmann unlocked the home defence to find Reus, who finished with aplomb.
Henrikh Mkhitaryan nearly levelled just a minute later, finding space on the left before firing a drive just wide of the post.
Dortmund's leading scorer Lewandowski came closer 10 minutes after the break, bursting through the heart of the defence before crashing a vicious strike off the post as Dortmund got on the front foot.
The Poland striker was again at the centre of proceedings 10 minutes later, breaking through on goal before being clipped by Niedermeier in the box, leaving Michael Weiner to produce a red card and point to spot.
Reus made no mistake from 12 yards out and a memorable afternoon for the midfielder was complete seven minutes from time, when he picked up a pass from substitute Pierre-Emerick Aubameyang on the edge of the box before sending a deflected effort past Ulreich.
C. Gentner 9'
1 - 0
2 - 0
2 - 1
30' M. Reus
(assist by J. Hofmann)
2 - 2
68' M. Reus (PG)
2 - 3
83' M. Reus
(assist by P. Aubameyang)
|S. Ulreich
|A. Boka
|D. Schwaab
|G. Niedermeier
|63' 67'
|A. Rüdiger
|C. Gentner
|I. Traoré
|D. Didavi
|C. Gruezo
|V. Ibišević
|M. Harnik
|Coach: H. Stevens
|R. Weidenfeller
|O. Kirch
|M. Hummels
|S. Papastathopoulos
|E. Durm
|S. Kehl
|H. Mkhitaryan
|M. Reus
|30' 68' 83'
|K. Großkreutz
|J. Hofmann
|R. Lewandowski
|Coach: J. Klopp
for D. Didavi 60'
for I. Traoré 70'
for M. Harnik 86'
for O. Kirch 60'
for H. Mkhitaryan 60'
for J. Hofmann 76'
|Pellegrini slams ´small team´ Chelsea´s approach
|Bundesliga Review: Leverkusen slip up, Cologne held in derby
|Martinez rues failure to build on strong start
|Sewe Sport 1 AC Leopards 0: Kouame strike seals slender advantage
|Scottish Premiership Review: Derby joy for Dundee United, Celtic held
|Vita Club 2 CS Sfaxien 1: Hosts seize advantage in semi-final
|Mixed emotions for Lampard after denying Chelsea
|Irvine hails best day so far
|Manchester City 1 Chelsea 1: Lampard denies former club
|Everton 2 Crystal Palace 3: Howard mistakes cost hosts dear
|Pearson praises Leicester City spirit
|Van Gaal laments United collapse
|Pochettino makes no excuses
|CSL Review: Evergrande leave it late, Liaoning Whowin edge thriller
|Leicester City 5 Manchester United 3: Hosts stage famous comeback
|Tottenham 0 West Brom 1: Morrison gives visitors deserved win
|Lee claims first Hong Kong gold in Incheon
|Sunderland v Stoke City: Poyet again up for the cup
|Ancelotti wants Real consistency
|Dortmund hit by Mkhitaryan injury blow
|Inzaghi pleased with Milan progress
|Monk: Hodgson will be back
|Pardew: Cisse should not have played
|We cannot entertain title challenge - Rodgers
|Bayern Munich v Paderborn: Visitors´ surprise start faces litmus test
|K. League Review: Suwon close gap on top two
|Empoli v Milan: Inzaghi eyeing top three
|MLS Review: Wright-Phillips treble inspires Red Bulls rout
|Bender: We lacked ambition
|McInnes unhappy after ugly bust-up
|Cambiasso impressed with Leicester mentality
|Valverde: Champions League is not an excuse
|Simeone wants improvement in discipline
|Conte keeping tabs on Pelle
|Marseille deserved to beat Rennes - Bielsa
|La Liga Review: Real end slump with rout, Atletico share spoils
|Hart unsure on City future
|Primeira Liga Review: Quinta inspires first Penafiel win, Braga claim late draw
|ES Setif 2 TP Mazembe 1: Late winner gives Algerians the edge
|Inzaghi upbeat despite defeat
|Victory not ´revenge´ for Allegri
|Simeone defends Jimenez
|Ligue 1 Review: Gignac double takes Marseille top
|Patience pays off for Tevez and Juventus
|Eredivisie Review: Vitesse drop points again, Dordrecht salvage late draw
|Serie A Review: Allegri wins on Milan return, Empoli fight back
|Milan 0 Juventus 1: Allegri wins on return to San Siro
|Klopp rues Dortmund display
|Allardyce lauds ´outstanding´ first-half performance
|Coton Sport 0 Al Ahly 1: Soliman screamer puts Egyptians in command
|Newcastle earned friends with comeback draw, claims Pardew
|Liverpool ´nowhere near the standard´ - Rodgers
|Atletico Madrid 2 Celta Vigo 2: Nolito penalty frustrates champions
|Bundesliga Review: Zinnbauer stops Bayern as Paderborn go top
|Lambert to close training ground after bug
|Poyet blasts lacklustre Sunderland
|Goals and wins are coming - Dyche
|Koeman calm after Southampton move second
|Bruce bemoans Hull errors
|West Ham 3 Liverpool 1: Hosts punish sloppy Reds
|Mainz 2 Borussia Dortmund 0: Klopp suffers miserable return
|Guardiola: Fixture congestion taking its toll
|Deportivo thrashing answered critics - Ancelotti
|League Two Review: Accrington thrill on Coleman return, Bury go top
|Bony ´distraught´ after dismissal - Monk
|Pardew praises senior players after Hull draw
|Wenger: Ozil showed mental strength
|League One Review: MK Dons hit Crewe for six, Swindon crush Sheffield United
|Championship Review: Fulham woes continue under Symons
|Scottish Premiership Wrap: Inverness overhaul Hamilton at the top
|Hughes credits QPR fans
|Aston Villa 0 Arsenal 3: Ozil shines as Gunners get back on track
|Swansea City 0 Southampton 1: Wanyama leaves it late to down 10-man hosts
|Deportivo La Coruna 2 Real Madrid 8: Ronaldo hat-trick helps end visitors´ Liga slump
|Newcastle United 2 Hull City 2: Late Cisse brace lifts pressure on Pardew
|Burnley 0 Sunderland 0: Both sides await first league win
|Hamburg 0 Bayern Munich 0: Zinnbauer starts Hamburg reign with impressive point
|Hosts strike gold on day two in Incheon
|Redknapp hails Kranjcar quality
|QPR 2 Stoke City 2: Kranjcar spoils Hughes´ Loftus Road return
|Howard not expecting European hangover
|J.League Review: Gamba clinch Osaka derby, Tokushima Vortis on the brink
|Vermaelen ´getting better every day´
|Rafael: I want to stay at United forever
|Ulloa determined to maintain strong form
|Vidic adjusting to Serie A referees
|Conte: There is room for a professional Balotelli
|Mourinho wants tougher sanctions for FFP breaches
|Milan v Juventus: Allegri returns to San Siro
|Allardyce lauds in-form Downing
|Real Salt Lake 5 Colorado Rapids 1: Poor visitors lose again
|Mignolet "aggressive", says Rodgers
|´Old´ City approaching dangerous position, says Neville
|Shakhtar´s Donbass Arena hit by shelling
|Song excited to face hero Gerrard
|Everything is normal, says Ancelotti
|Partick Thistle 1 St Mirren 2: Craig´s side off the mark
|Elche 0 Eibar 2: Hosts´ unbeaten run comes to an end
|Freiburg 2 Hertha Berlin 2: Ronny strikes twice to deny hosts
|Bordeaux 2 Evian 1: Hosts back on track against dismal strugglers
|Willem II 2 NAC Breda 1: Braber leaves it late
|Simeone: Confidence high at Atleti
|Arsenal announce increased turnover
|Paris Saint-Germain v Lyon: Jallet relishing PSG reunion
|Consortium complete Reading takeover
|Pearson relishing United test
|Carlisle look to Curle
|Tottenham v West Brom: Fully-fit visitors seek to end White Hart Lane hoodoo
|League Two Preview: Coleman makes Stanley return, Curle in at Carlisle
|Allegri expects emotional Milan return
|Everton v Crystal Palace: Martinez expecting tough test
|Tonev issued notice of complaint
|Leicester City v Manchester United: Pearson vows to attack resurgent visitors
|Palermo v Inter: Mazzarri urges visitors to maintain standards
|Van Gaal plays down Ronaldo rumours
|Manchester City v Chelsea: Costa and Aguero defy injury in title clash
|Symons wants Fulham job
|Bournemouth loan Boruc from Southampton
|Levante v Barcelona: Visitors happy to continue with rotation
|Mandzukic out for up to two weeks
|Attacking threat pleases Martinez
|League One Preview: Page starts new Vale chapter, Bristol City out to extend run
|Mourinho admits Real desire
|Assou-Ekotto banned for Anelka tweet
|Pellegrini made me a scapegoat - Richards
|UEFA open proceedings against Partizan
|Guardiola warns of Hamburg backlash
|Pellegrini rejects Toure criticism
|Mourinho confirms Costa will start against City
|Inzaghi plays down Allegri rift
|Confident Swansea can beat Southampton - Sigurdsson
|Jardim not expecting Guingamp to struggle
|London to host Euro 2020 final
|We need fans´ support - Coloccini
|Eckert sets November target for corruption verdict
|Warnock taking no risks over Chamakh
|Redknapp bemoans Taarabt fitness issues
|Bruce out to capitalise on Newcastle problems
|Wenger hits out at Ozil critics
|Rodgers: Sturridge could be fit for Merseyside derby
|Juve move has given me confidence - Morata
|We have more to come - Naismith
|Pardew wants an end to ´mass hysteria´
|Lille did not do enough, says Girard
|Championship Preview: Fulham, Cardiff out to end weeks of turmoil
|Pulis keen to manage again, speaks of Palace respect
|Montella lauds Fiorentina´s spirit
|CONCACAF Champions League Review: Sporting Kansas City, Herediano win well
|Van Gaal will get United back into Europe - Robben
|Emery: We will rely on our entire squad
|Copa Sudamericana Review: Boca march into last 16, Emelec on track
|Delph, Vlaar on Lambert hit list
|Brazilian Serie A Review: Cruzeiro bounce back, Sao Paulo stunned
|Copa Argentina Review: San Lorenzo, Racing Club eliminated
|We cannot afford to lose - Silva
|Murphy interested in Fulham job
|Hecking furious after heavy loss
|Dyke denies gift involvement
|Napoli response pleases Benitez
|Brandao handed six-month ban
|Arena fined for MLS comments
|Arena fined for MLS comments
|Martinez enjoys ´special evening´


text:
Help navigation
Granta signs Duffy and Bullough
Granta has signed two new n...
Harvill Secker signs more from Dolan
Harvill Secker has acquired...
Mitchell Beazley signs cookery from Honor
Octopus Publishing Group&rs...
Two from Moshfegh for Cape
Jonathan Cape has bought tw...
Aurum Press signs Ambrose cricketing memoir
Aurum Press has acquired th...
Virago signs Everything But the memoir
06.10.11 | Benedicte Page
Tracey Thorn, one half of the band Everything But the Girl, has signed a book deal for her memoir with Virago.
Editor Rowan Cope bought UK and Commonwealth rights through Kirsty McLachlan at DGA Ltd. Cope called herself "hugely excited" by Thorn's memoir, which she called "one take on how to be a woman artist" and almost a companion piece to Caitlin Moran's How to Be A Woman.
She said: "As in her song lyrics, her writing is honest, moving, perceptive and very funny, and the book offers a vivid and appealing portrait of her personal and artistic journey through the 1980s and 1990s, with the Marine Girls, Everything but the Girl and as a solo artist."
The as yet untitled book will be published in early 2013, with DGA Ltd selling US and translation rights at Frankfurt.


text:
Adc Products
More Premier Diagnostic Medical Products Available at theEMSstore.com
theEMSstore.com, the fastest growing online source for EMS equipment and supplies, has partnered with ADC, to deliver premier medical diagnostic products 24-hours a day. Shopping theEMSstore.com online or via your smartphone provides unlimited access to research and order ADC products.
Featured Careers & Jobs in EMS
Fire EMS Blogs
Blogger Browser
Today's Featured Posts
EMS Airway Clinic
Simulation-Based Assessment Facilitates Learning & Enhances Clinical Judgment
Simulation is an educational tool that can be used to develop and refine clinical skills of the student in a controlled environment before they progress to becoming practicing clinicians.
More >
Delaware Bus Crash MCI
A view from the triage sector as EMS crews work on several patients.
Watch It >
REMSA Programs Helps Reduce Hospital Visits
Community paramedic effort goes into service.
Watch It >
City Official Challenges San Francisco Fire Chief
Ambulance response times among problems noted by city supervisor.
Watch It >
Texas Ambulance Crash
Victoria ambulance collides with civilian vehicle.
Watch It >
North Dakota Oilfield Medics
Tactics used in offshore platforms tailored to the remote areas.
More >
Delaware Bus Crash MCI
A view from the triage sector as EMS crews work on several patients.
More >
CO Leak at Illinois School
Girard incident sends over 130 to hospitals.
More >
The AmbuBus®, Bus Stretcher Conversion Kit - EMS Today 2013
AmbuBus®, Bus Stretcher all-hazards preparedness & response tool
Watch It >
Field Bridge Xpress ePCR on iPad, Android, Kindle Fire
Sneak peek of customizable run forms & more.
Watch It >
VividTrac offered by Vivid Medical - EMS Today 2013
VividTrac, affordable high performance video intubation device.
Watch It >
EZ-IO® Intraosseous Infusion System Real Time Humerus Infusion
Leg access using the EZ-IO.
Watch It >


text:
Marvel Now/ReEvolution Ongoing Discussion (Spoilers)
View Single Post
June 25 2013, 05:45 AM
Nerys Myk
Fleet Admiral
Location: House of Kang, now with ridges
Re: Marvel Now/ReEvolution Ongoing Discussion (Spoilers)
Did you miss the part about the entire planet being under the control of Miracle Man and Co.?
I bought them off the rack ( okay, my shop actually pulled them for me, so they were never on a rack)
The boring one, the one with Khan, the one where Spock returns, the one with whales, the dumb one, the last one, the one with Kirk, the one with the Borg, the stupid one, the bad one, the new one, the other one with Khan.
Nerys Myk
View Public Profile
Send a private message to Nerys Myk
Find More Posts by Nerys Myk


text:
American Yacht Club, RyePlease join the White Plains Chapter, National Society Daughters of the American Revolution (NSDAR) on Thursday, October 23rd from 6 – 9 pm as we host Dr...
Elmhurst community events
White Plains DAR 2014 Fall Benefit
Thursday, Oct 23 6:00p
The Annual Hunts Point Tent Party 2014
Thursday, Oct 9 1:00p
Bronx, BronxThe Business Networking Party of the Year for Hunts Point For over 27 years, the Hunts Point Tent Party has now extended as of last year to an annual business celebration week which offers business...
WCFF Film Series 10
Saturday, Oct 18 12:00p
New York Instiute of Technology (NYIT), New YorkSaturday, October 18 Series 10 12:00-2:00 pm "Baily Head, Antarctica" Speechless Series Richard Sidey, Producer Country: New Zealand * New York Premier 3 minutes "The Return of the Musk Ox" Vesil...
New Year's Eve Dance Party
Wednesday, Dec 31 8:00p
Buttenwieser Hall, New YorkWed, Dec 31, 8 pm. Location: Lexington Avenue at 92nd St
The Amazing Brooklyn Museum Scavenger Hunt
Saturday, Oct 18 12:30p
Brooklyn Museum, BrooklynPOGO Events presents The Amazing New York Scavenger Hunt - part scavenger hunt, part obstacle course and ALL Brooklyn Musuem! A series of clues leads you around the Brooklyn Museum performing menta...
Diversity & Recruitment and Job Fair on Healthcare
Thursday, Sep 25 9:00a
First AMEZ Church, BrooklynThe Way Forward Project is a Diversity & Inclusion Workforce Development program who's vision is to create opportunities for the collegiate community and recognize innovative ways to partner with o...
11th Annual Hedge Fund Rocktoberfest
Wednesday, Oct 22 7:00p
Capitale, New YorkA Leg To Stand On's ("ALTSO") Hedge Fund Rocktoberfest unites over 1,400 leaders from the hedge fund & finance industries for a night of rock & roll performed by key players in the hedge fund indus...
Super Duper Alice Cooper
Monday, Oct 27 7:00p
Kaufmann Concert Hall, New YorkWelcome to the nightmare! Join us for a screening of the documentary film Super Duper Alice Cooper followed by a conversation with Alice Cooper led by Rolling Stone's Anthony DeCurtis...
Senator Kirsten Gillibrand With Gloria Steinem: Off The Sidelines
Sunday, Sep 28 2:30p
Kaufmann Concert Hall, New YorkNew York Senator and rising political star Kirsten Gillibrand is urging all women to get involved politically and make their voices heard...
Ya Lit at 92Y: Gena Showalter and Jennifer L. Armentrout
Friday, Nov 21 7:00p
Ghost Doctors American Museum of Natural History Ghost Hunting Tours
Saturday, Oct 4 3:45p
American Museum of Natural History, New YorkNew and limited to small groups!Real Ghost Hunting comes to The American Museum of Natural History! Join NYC's own "Ghost Doctors" (paranormal investigators and licensed tour guides) as they actual...
The Marshmallow Test: Mastering Self-Control
Monday, Sep 29 7:30p
Buttenwieser Hall, New YorkIs self-control the secret to success in life? Is it prewired, or can it be taught?Walter Mischel's groundbreaking marshmallow test-in which children were presented with two marshmallows and given ...
High Holy
Thursday, Sep 25 10:00a
27 Reasons to Eat Dark Chocolate Every Day!
Thursday, Oct 30 7:00p
How to Have Better Sex
Wednesday, Dec 3 7:00p
Elmhurst community Related Topics
activism | antiques & collectibles | charity & volunteer | civic/government | clubs | ethnic & cultural | health | history | home & garden | libraries | parades | pets | religion | science | talks & lectures | central lounge -carnival of love foundation? | wellness | sax | sex | xxxxx | vendor | the night the music lived | volunteer | human resource | restaurant | fashion | write act rep theatre -west 43rd st | beauty | when is lego festival in ny or nj | a mother's love schedule in new york | party | xxx | poetry | harmonious | 9/11 cultural festival
Hot Tickets More »
Tue 11/11 7:00p
Tue 11/25 7:00p
Fri 4/3 6:00p
Wed 12/10 7:00p
Sat 1/17 12:00p
Thu 10/23 6:00p
On Sale: Fri 9/26Tue 10/28 7:00p
Upcoming Holiday Events More »
Doris Dear's "Gurl Talk"
Sun 10/5 7:00p
Pisser At Bt51
Fri 9/26 7:00p
Central Park Ghost Hunting Tour
Sat 9/27 9:00p
Central Park Ghost Hunting Tour
Sat 10/4 9:00p
Metropolitan Museum of Art Ghost Hunting Tours
Sat 10/4 5:00p


text:
- Username: jennypara
- Member Since: 2011-01-18
- Real name: jennypara
- MSN: email@example.com
- Bio:I love my life~
Log in!Register Lost password
You won't see stories with a lower score when you browse or search. Log in to adjust filter.
Featured Story
Fragileby Demenior (PG-13)
How fragile is life? How good is it to keep a secret from someone, even when you don't want to break...
Site Stats
- Authors: 655924
- Stories: 39947
Recent Stories
Speed of Lyghtby J_Linz (PG-13)
Tabitha Lyght, an Army Reservist, finds herself mutated from a military experiment gone wrong, givin...
Remember Me for Centuriesby meesheemooroo (R)
A magical Patrick/o.c story. There's no doubt Paige is a nerd and her best friend ,Amelia isn't. Tog...
In: Fall Out Boy
Rapture Like Bloodby Noizchild (R)
Eighth one in my series, "Ghost Doll." Three cases in one: missing and moving corpses, Hotaru's frie...
In: Yami no Matsuei
Forbidden Attractionby glostick86 (PG-13)
One married woman, one semi-single guy. What happens when sparks fly where they shouldn't.
In: Romance
Pure Morningby Noizchild (R)
Seventeenth book in the "Ghost Doll" series. Marriage is a burning thing. Tsuzuki and Anna try to fi...
In: Yami no Matsuei


text:
Sort by: [Top
Recent Book Searches:
0446675067 / 978-0446675062 / The Ancient Wisdom of the Chinese Tonic Herbs / Ron Teeguarden
0446675504 / 978-0446675505 / Parable of the Sower / Octavia E. Butler
0446675555 / 978-0446675550 / Big Government / Ev Ehrlich
0446675571 / 978-0446675574 / If I Only Knew...What Would Jesus Do? / Joan Hake Robie
0446675717 / 978-0446675710 / Benjamin's Gift / Michael Golding
0446676160 / 978-0446676168 / The Harvard Lampoon's(TM) Guide to College Admissions: The Comprehensive, Authoritative, and Utterly Useless Source for Where to Go and How to Get In / Harvard Lampoon(TM)
0446676195 / 978-0446676199 / How to Save Your Own Life: The Eight Steps Only You Can Take to Manage and Control Your Health Care / Marie Savard, Sondra Forsyth
0446676209 / 978-0446676205 / Bosom Buddies: Lessons and Laughter on Breast Health and Cancer / Rosie O'Donnell, Tracy Chutorian Semler, Deborah Axelrod
0446676276 / 978-0446676274 / The Little Soy Book / Erika Dillman
0446676667 / 978-0446676663 / 10 Days to a Sharper Memory / Russell Roberts, Abby Marks-Begie, Lenny Laskowski, Tom Nash
0446676683 / 978-0446676687 / 10 Days to More Confident Public Speaking / The Princeton Language Institute, Lenny Laskowski
0446675059 / 978-0446675055 / The Honk and Holler Opening Soon / Billie Letts
0446675199 / 978-0446675192 / The Perfect Palette: Fifty Inspired Color Plans for Painting Every Roomin Your Home / Bonnie Rosser Krims
0446675474 / 978-0446675475 / Your Best Year Yet!: Ten Questions for Making the Next Twelve Months Your Most Successful Ever / Jinny S. Ditzler
0446675679 / 978-0446675673 / The Portable Pundit: A Crash Course in Cocktail Party Conversation / T. E. Krieger
0446675741 / 978-0446675741 / Taming It Down / Kim McLarin
0446675806 / 978-0446675802 / Outsmarting the Female Fat Cell: The First Weight-Control Program Designed Specifically for Women / Debra Waterhouse
0446676047 / 978-0446676045 / Seize Tomorrow, Start Today: Renew Your Vision, Revitalize Your Organization, and Stay Ahead of the Future / James A. Belasco, Jerre Stead
0446676179 / 978-0446676175 / Lightposts for Living: The Art of Choosing a Joyful Life / Thomas Kinkade
0446676292 / 978-0446676298 / 52 Saturday Nights: Heat Up Your Sex Life Even More with a Year of Creative Lovemaking / Joan Elizabeth Lloyd
0446676462 / 978-0446676465 / How to Work a Room: Learn the Strategies of Savvy Socializing - For Business & Personal Success / Susan Roane
0446674672 / 978-0446674676 / The Outfit (Parker Novels) / Richard Stark
0446674923 / 978-0446674928 / 401(k) Take Charge of Your Future: A Unique and Comprehensive Guide to Getting the Most Out of Your Retirement Plans (Money America's Financial Advisor) / Eric Schurenberg
0446674990 / 978-0446674997 / The Shy Child: Helping Children Triumph over Shyness / Ward K. Swallow
0446675261 / 978-0446675260 / Backflash (Parker Novels) / Richard Stark
0446675393 / 978-0446675390 / Prince William: Prince of Hearts / Lisa Degnen
0446675539 / 978-0446675536 / Gone with the Wind / Margaret Mitchell
0446675687 / 978-0446675680 / A Song for Mary: An Irish-American Memory / Dennis Smith
0446675776 / 978-0446675772 / Kiss My Tiara: How to Rule the World as a SmartMouth Goddess / Susan Jane Gilman
0446675970 / 978-0446675970 / I Love Gootie: My Grandmother's Story / Max Apple
Browse ISBN Directory:
9780761807346-9780761808732 9780761808749-9780761810162 9780761810179-9780761811619 9780761811626-9780761813033 9780761813040-9780761814450 More...
More About Using This Site and Buying Books Online:
Be Sure to Compare Book Prices Before Buy
This site was created for shoppers to compare book prices and find cheap books and cheap college textbooks. A lot of discount books and discount text books are put on sale by many discounted book retailers and discount bookstores everyday. You just need to search and find them. Our site provides many book links to some major bookstores for book details and book coupons. But be sure not just jump into any bookstore site to buy. Always click "Compare Price" button to compare prices first. You would be happy that how much you could save by doing book price comparison.
Buy Books from Foreign Country
Our goal is to find the cheapest books and college textbooks for you, both new and used books, from a large number of bookstores worldwide. Currently our book search engines fetch book prices from US, UK, Canada, Australia, New Zealand, Netherlands, Ireland, Germany, France, and Japan. More bookstores from other countries will be added soon. Before buying from a foreign book store or book shop, be sure to check the shipping options. It's not unusual that shipping could take 2 -3 weeks and cost could be multiple of a domestic shipping charge.
Buy Used Books and Used Textbooks
Buying used books and used textbooks is becoming more and more popular among college students for saving. Different second hand books could have different conditions. Be sure check used book condition from the seller's description. Also many book marketplaces put books for sale from small bookstores and individual sellers. Make sure to check store review for seller's reputation when available. If you are in a hurry to get a book or textbook for your class, you would better choose buying new books for prompt shipping.
Please See Help Page for Questions
regarding ISBN / ISBN-10 / ISBN10, ISBN-13 / ISBN13, EAN / EAN-13, and Amazon


text:
Trainers Near You
Ashburn VA change location
Arman Ali
olney, MD
Eileen Grant
alexandria, VA
Shannon Dolan
poolesville, MD
ACE Fit Share
November 9, 2011
If you missed this morning's episode of "The Balancing Act" featuring ACE's Chris Freytag discuss exercise and diabetes, watch the clip below:
Want to watch more ACE on "The Balancing Act" clips?
If you found this to be article useful to you or someone else, please share it with your friends!
What are some pilates-inspired exercises that will tone my body?
ACE Salutes the Military This Veterans Day
Fit Life Articles
We all know how exercising can produce weight loss, good-looking muscles and a healthier heart. But what about those other side effects— the post-workout hunger cravings, chafed spots on your legs and arms, and the mountain of dirty, sweaty laundry? ACE Certified Pro Chris...
The last days of summer are here, but that's no reason to lose the summer body you've worked so hard to achieve. ACE Certified pro Chris Freytag offers four great tips for keeping your body strong and healthy well into the colder months of the year.
Ready to firm up those upper arms once and for all? ACE Certified pro Sabrena Merrill offers up a trio of triceps exercises that, along with a comprehensive fitness plan and balanced diet, are sure to improve the shape, tone and strength of the upper arms.
ACE Pro Homepage
Copyright © 2014 The American Council on Exercise. All Rights Reserved.
4851 Paramount Drive, San Diego, California 92123 1 (888)-825-3636


text:
Free Forum : Help and support to Forumotion users. Create and administrate a forum. Discover our guides, tutorials, tips on the Forumotion's Support Forum.
#free, forums, forum, create, make, admin, administrate, configure, tips, support, help, tutorials
Home of all things Battrick Related, Sports and Everything Else
Free forum : Paint Shop Pro Hobbies
paint, shop, #free, forum, signature, tags, hobbies, friendship
Free forum : The romance dawn is non-canon forum RP where people can role-play as a pirate, a marine or a revolutionist in the world of One Piece.
#free, forum, theromancedawnrp, romance, dawn, non-canon, where, people, role-play, pirate, marine, revolutionist, world, piece
Welcome to the Planetary Pit Stop, a place for friendly conversation between. . . friends! Remember: You can check out any time you like, but you can never leave.
#free, forum, planetary, stop, forumotion, general, media, pokémon, conversation, minecraft, let's, play, roleplay, community, gaming
Free forum : Quality Mods For Farming Simulator 2013
#free, forum, american, iron, modding, quality, mods, farming, simulator, 2013
Free forum : Many different types of people live here. Including nekos.
world, neko, many, different, types, people, live, here, including, nekos, thenekosworld, thenekoworld, thenekoworld.com
Free forum : Want to learn how to develop your psychic power? - Telepathy - Telekinesis - Clairvoyance - Precognition - Extra Sensory Perception Hopefully we can all work together to better our unders
psychic, telekinesis, psychokinesis, learn, clairvoyant, develop, your, power?, telepathy, clairvoyance, precognition, extra, sensory, perception, hopefully
Free forum : A place to share your passion for the WR250R!
yamaha, wr250r, dirt, bike, dual, sport, adventure, riding, ride, reports, maintenance, reviews
Free forum : a place to talk about your favorite shows, movies and current events
forum, walking, dead, game, thones, true, blood, lost, breaking, show, reviews, discussion, current, affairs, community, american, horror, story
Free to play, immersive Dragon Ball Z roleplay site. Custom characters, races and you can even control planets and command an army. Or defend the Earth to your last breath.
#free, forum, game, dragon, ball, dragonball, roleplay, active, freedom, writing, custom, races, anime, nerd, fansite
Free forum : Bliss is an active, skilled and friendly clan. We are here to have fun and enjoy all the good moments. Time has come for Bliss to shine in Begone. Like a storm from above, or a bunch of
#free, forum, bliss, active, skilled, friendly, clan, here, have, enjoy, good, moments, time, come, shine, begone, like
Free forum : This is an RP site. We embrace many different kinds of RPs. You can join one of the many that we already have, or contact the site Admin, Dark Soul, to make your own RP.
#free, forum, darkness, falls, site, creative, dino, based, written, human, humanoid, vampire, demon, werewolf, wolf, space, pirate
Forza Motorsport's Touge Community


text:
Saint Michael's exists to help people with terminal illness to live and die well. We do this by offering specialist care, comfort and support, free of charge, to patients and their families. We are an independent charity working in the Harrogate District.
Skydiving, Bike Rides, Runs...
A special challenge for you, an extraordinary difference to others.
With 32 cash prizes up for grabs and your £1 going straight to helping patients at Saint Michael's, whether your number comes up or not... everyone's a winner.
Bargain hunters rejoice! Head to our Recycling Centre on Saturday September 27 for a two-hour flash sale of fabulous furniture, homeware and collectables.Continue Reading
Put King Leonidas and his 300 to shame with this gruelling 5km+ obstacle course set to challenge even the most fearless athletes.
A popular dawn fundraising walk in support of local people living with terminal illness is returning to Ripon for a fifth year with a brand new route. The Saint Michael's Sunrise Walk, sponsored by Eu...Continue Reading
A Harrogate and Ripon-based hair salon have revealed that they will once again take part in prominent charity challenge, You're Inspired, after exposing their fundraising talents with a risqué calenda...Continue Reading
Saint Michael's has appointed Dr Liz Brown as the Hospice's new medical director. The announcement was made by the charity's chief executive, Tony Collins, and comes as the charity continues to delive...Continue Reading