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- Welcome
- About
- Archives
- Box Office
- CFA Blog
- CFA E-Mail Newsletter
- Creative Campus
- Departments
- Events
- Galleries
- Institute for Curatorial Practice in Performance
- Opportunities
- Plan Your Visit
- Press
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Wesleyan Home → Center for the Arts → Opportunities
Tickets for Béla Fleck and Abigail Washburn are on sale now. Purchase tickets online here. The rest of the 2016-2017 season at the Center for the Arts will be announced in August.
The Wesleyan University Box Office opens for walk-up and phone sales at 860-685-3355 on Tuesday, August 23, 2016.
Socialize with Us
Spring Photos: Feet to the Fire – Riverfront Encounter


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Tuesday, August 14th, 2012
Complete Obituary
Betty Jean Brockman
Betty Jean Brockman, 83, Fort Recovery, died Aug. 13, 2012, at Mercer County Community Hospital, Coldwater.
She was born Aug. 28, 1928, in St. Henry, to Harry and Pauline Albers Bergman. On July 10, 1948, she married Cyril "Cy" Brockman, who died Jan. 5, 2009.
Surviving are five sons, Cy Jr. (Linda) Brockman, Mike Brockman, Mitch Brockman and Jim (Pat) Brockman, all of Fort Recovery, and Joe (Pat) Brockman, Portland, Ind.; two daughters, Vicky (Roger) Knapke, Coldwater, and Brenda (Mark) Eichenauer, Fort Recovery; three brothers, Melvin (Peg) Bergman, Fort Recovery, Jack (Jean) Bergman, St. Henry, and Floyd (Joan) Bergman, Fort Recovery; two sisters, Marjorie Vogel, Coldwater, and Elsie (Roscoe) Timmerman, Fort Recovery; three sisters-in-law, Kathryn Bergman, Mercedes Bergman and Lillian Brockman, all of Fort Recovery; 23 grandchildren and 34 great-grandchildren.
Deceased are a sister, Ruth Finch; four brothers, Ralph, Bob, Walter and Lavern Bergman; and a brother-in-law, Vernon Brockman.
She formerly worked at Brockman Funeral Home, Brockman Furniture and Brockman Appliances, all of Fort Recovery.
A 1946 graduate of Fort Recovery High School, she was a member of Mary Help of Christians Catholic Church, its Altar Sodality, the American Legion Auxiliary, Veterans of Foreign Wars Auxiliary and Daughters of Isabella Circle 810, all of Fort Recovery, and the Catholic Knights of America, St. Joe.
Funeral Mass is 10:30 a.m. Thursday at the church, the Rev. Thomas Dorn officiating. Burial will follow at St. Marys Cemetery, Fort Recovery.
Calling is 2 to 8 p.m. Wednesday and 9 to 10 a.m. Thursday at Brockman-Boeckman Funeral Home, Fort Recovery.
Condolences may be left at www.brockmanboeckmanfh.com.
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subset: commoncrawl


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August 3, 2016
How Can Fiscal Rules Fix the American Government? Event
Dr. Barry Poulson warns about the impending financial collapse of the United States economy, which is the largest and most influential in the world. A $20 trillion federal debt calls for a new fiscal rule: a national debt brake.


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Finger Hoola iOS
- Publisher: Plant Pot
- Release Date: Dec 5, 2012
- Summary: LAUNCH SALE 50% OFF!Spin rings around your fingers and escape into a world of ambient sound and abstract shapes.Develop your dexterity and unwind your mind.WARNING: Moments of meditative focus can lead to sensory climax. Grass skirt NOT required.
- Developer: Plant Pot
- Genre(s): Miscellaneous
- Cheats: On GameFAQs
- More Details and Credits »
Score distribution:
Positive: 2 out of 3
Mixed: 1 out of 3
Negative: 0 out of 3
Apr 1, 2013A chilled-out and peaceful challenge, quite unlike anything else around, Finger Hoola is just lovely.
Dec 7, 2012A unique idea that's well implemented, Finger Hoola might be a bit thin, but it's still a lot of fun.
Hyper MagazineMay 9, 2013There's a great feeling of responsiveness to Finger Hoola that makes the wold weird project work, more or less. [June 2013, p.84]


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Release Date:
April 1, 2008
This average collection of outtakes from a bunch of medium-level rockers assembled for an amusing but forgettable teen horror comedy is for completists who must have everything by Matthew Sweet, Susanna Hoffs, Toad the Wet Sprocket, the Divinyls (a reasonable cover of "I Ain't Gonna Eat Out My Heart Anymore"), Ozzy Osbourne, or the Cult. Post-Judas Priest singer Rob Halford has a solo selection, "Light Comes Out of Black." William Ruhlmann, Rovi
- Genre: Soundtrack
- Format: CD
- Release Date: April 1, 2008
- Artist: Original Motion Picture Soundtrack
other Info.
- Online Item #: 11576687
- Store Item Number (DPCI): 244-06-6741
- Made in the USA or Imported


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Hotel address118/16 Moo 3
Tambon Kamala, Amphur Kathu
How to reach the hotel
Contact the hotel
- Tel. (+66)76/303700
- Fax. (+66)76/303777
- email@example.com
Recently viewed hotels
Novotel Phuket Kamala Beach - hotel description
Hotel code: 7235
Novotel Phuket Kamala Beach is located on the west coast of Phuket on Kamala Beach, near Phuket Fantasea and about 30 minutes from Phuket International Airport. The resort offers amazing views of the Andaman Sea and features direct beach access, an all-day dining restaurant & roof top bar overlooking the sea, lobby bar, swim up pool bar, swimming pool, In-Balance Spa & Fitness, Kids Club, Free Parking, WiFi, complimentary shuttle service to Patong and modern conference & meeting spaces.
See the rooms
See the meeting rooms
Extras of this hotel
Beautiful 120 metre pure beach frontage, free WiFi, free shuttle to Patong, a unique rooftop bar with an amazing 180° view of Kamala's clear turquoise waters with stunning sunsets, this experience makes it an absolute must for travelers of the area.
Message from the hotel manager
Mr Mike SMITH, the manager of the Novotel Phuket Kamala Beach hotel, would like to welcome you.
Destination overview
Novotel Phuket Kamala Beach is located on Kamala Beach and offers a perfect base to explore the western side of the Island. Nearby attractions are the Fantasea Show and the Buddhist Temple (Wat Baan Kamala) at the south endof the beach. A vibrant local restaurant scene is accessible by a 10 min walk across the beach with Jungceylong Shopping Mall in Patong a short taxi trip away.
Work in this hotel
These prices may be based on different room types. Depending on the country, these prices may not include taxes, may include VAT only or may include all taxes (VAT and city tax). When prices do not include all taxes, the relevant taxes (VAT and/or city tax) will be stated in the following stages of the reservation process. The price is only guaranteed at the time of reservation.
2. Paying
Hotel classifications (1 to 5 stars for France) correspond to criteria laid down by local regulations.


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Man in smart clothing
Credit: John and Tina Reid
Creative #: 142184798
Licence type: Royalty-freeRoyalty-free pricing is based solely on the size of the product you need, not the specific use. You don't have to pay any additional royalties on a use-by-use basis. Once you license a royalty-free product, you may use it multiple times for multiple projects without paying additional fees. (Pornographic, defamatory, libellous or otherwise unlawful use of any image is, of course, prohibited.)
Collection: Moment
Release info: Model released
- 20-24 Years,
- Adult,
- Adults Only,
- Belt,
- Black Background,
- Brown Hair,
- Close-Up,
- Colour Image,
- Confidence,
- Cool Attitude,
- England,
- Fashion,
- Fashion Model,
- Fashionable,
- Focus On Foreground,
- Glamour,
- Grey Eyes,
- Handsome,
- Holding,
- Hood - Clothing,
- Latin American and Hispanic,
- Lifestyles,
- London - England,
- Looking At Camera,
- One Man Only,
- One Person,
- One Young Man Only,
- Only Men,
- People,
- Photography,
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- Serious,
- Smart,
- Standing,
- Stubble,
- Studio Shot,
- Tie,
- Vertical,
- Waist Up,
- Young Adult,
Similar imagesSearch ResultsSame series
Man In Smart Clothing Stock Photo20-24 Years,Adult,Adults Only,Belt,Black Background,Brown Hair,Close-Up,Colour Image,Confidence,Cool Attitude,England,Fashion,Fashion Model,Fashionable,Focus On Foreground,Glamour,Grey Eyes,Handsome,Holding,Hood - Clothing,Latin American and Hispanic,Lifestyles,London - England,Looking At Camera,One Man Only,One Person,One Young Man Only,Only Men,People,Photography,Portrait,Serious,Smart,Standing,Stubble,Studio Shot,Tie,UK,Vertical,Waist Up,Young AdultPhotographer John and Tina ReidCollection: Moment Jon and Tina ReidPortrait of man in smart clothing against black background.


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Bonds, Robinson share common desire
Jackie Robinson became the first black man to play major league baseball on or about May 9, 1947, while being the target of racial epithets, death threats, pitchers throwing at his head, catchers spitting on him and crowds jeering at him.
National League president Ford Frick headed off a players strike aimed at forcing Robinson out of the game. New York Herald-Tribune Sports Editor Stanley Woodward reported that Frick said, "I do not care if half the league strikes, those who do it will encounter quick retribution. This is the United states of America and one citizen has as much right to play as another."
Almost 59 years later, the only thing Barry Bonds has been found guilty of is having the same desire as Jackie Robinson to play major league ball.
The current high-tech lynching is not the American way and it sends the wrong message to others who want to become Americans.
Rev. Rupert Brashears
More drug users should get Limbaugh treatment
About three years ago, Rush Limbaugh confessed he had been addicted to prescription pain pills for years. He was arrested on a felony drug charge of prescription fraud on April 30.
However, his attorneys where able to cut a deal with prosecutors that will result in the charge being dropped if Limbaugh completes a drug rehab program and stays drug-free for 18 months.
On several occasions, Limbaugh has advocated tougher penalties for drug-users, stating that they should do prison time. His lawyers and the prosecution must not share this tough stance.
Can anything good come from such barefaced hypocrisy?
Perhaps if the far right can sympathize with a man who, like Limbaugh, accidentally became addicted to pain pills during treatment for back pain, they can learn to sympathize with drug abusers who tried an addictive substance as youths and became hooked. The latter usually are condemned as moral failures by the far right.
Despite the hypocrisy surrounding Limbaugh's bargain with prosecutors, the court did what was right: treating an addict as someone who needed help, not punishment; rehabilitation instead of incarceration. Hopefully, future courts can extend this reasonable, effective, compassionate approach to non-famous, non-white, non-rich drug offenders.
Billy Mosteller
How to get them scrambling to cut prices
The price of a dozen eggs was just right at 69 cents a dozen; then the price started rising until it was $2 a dozen.
People got tired of that, so someone suggested that everyone just buy however many eggs they needed for the day, like two or three. Soon this started to cause a logjam of eggs, and everyone from the farmer to the grocer had to lower the price.
That same principle would work with the gas situation. If everyone only bought what they needed for the day, like $10 for three gallons, then the gas would start to build up in the storage tanks and they would have to cut the price.
I think this would work.
Kenneth Gibbs
Amarillo Globe-News © 2016. All Rights Reserved. Terms of Service | Privacy Policy / About Our Ads


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When you come to Jasper Missouri be sure and visit the Beier Christmas Display at Lexington and 4th St. Enter on Lexington St and tune your radio to 106.7 FM to hear the music. The display runs from 5 pm to 10:30 pm everyday. It is free with a donation box at the exit with the money being donated to the Jasper R-5 Bright Futures program. When you done be sure and visit one of our restaurants in town. McKay's Dari Creme on 4th St, Gem Dandy Pizza downtown or our famous Judy's Cafe and Truck-stop.Type your paragraph here.
City of Jasper
121 E. Grand Ave
Jasper Police Department
109 S. Main St
Jasper Fire Department
831 E. Grand Ave
Jasper School District
201 W. Mercer
Jasper Post Office
122 W. Grand Ave
Senator Ron Richards * 573-751-2173
State Representative * Mike Kelley 573-751-2165
County Commissioner * Jim Honey 417-358-0421
P.O. BOX 314, Jasper, MO 64755 417-394-9914


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Clare Campbell
With a radical and irreverent approach, Clare Campbell carries poetry, hope, circle work, creativity and art to new audiences: from prisons to housing estates, government conferences to dole queues… reawakening lost dreams and inspiring a bigger vision of what is possible.
A highly experienced facilitator, she has worked with thousands of people at workshops and retreats, as well as speaking at conferences around the world.
Below is a sample of some of the magic Clare is offering over the next year… click on the images for more information…


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To hear Katie Dugger tell it, you'd think catching a baby northern spotted owl (Strix occidentalis caurina) for scientific banding was as easy as taking a Tootsie Roll from a toddler. "They're so mellow and laid-back," the ornithologist says. "If the owl is sitting low enough in a tree, as is often the case, you […]
Category » Healthy Planet
October 13, 2014
Of Spots and Stripes
October 13, 2014
Back from Prehistory
The "butifull Buzzard of the Columbia " was Captain William Clark's descriptor in 1805 for the prehistoric vultures he observed riding thermals on 9-foot wings in the Columbia River Gorge. Yet just 100 years later, the giant condors were all but gone in Oregon. Now, ornithologist Susan Haig is helping to bring them back. At […]
October 13, 2014
A Rocky Outlook
A light wind froths across the headland, kicking up the churn below. Just off Yaquina Head, atop a sea stack named Colony Rock, more than 60,000 seabirds huddle in a wing-towing crush. Audible from shore is a raucous din, the collective cry of nesting females incubating eggs and raising chicks while their mates fly in […]
October 13, 2014
A Moveable Feast
When Dan Roby floated the idea of relocating 18,000 seabirds in 1999, there was a lot of eye-rolling among wildlife experts in Oregon. "No one believed it would work," says Roby, an ornithologist at Oregon State University specializing in marine species. But everyone agreed that something had to be done. With suitable seabird habitat shrinking […]
October 11, 2014
A Delicate Balance
Nothing looks more vulnerable than a meadowlark hatchling: a scrap of fluff, a fraction of an ounce, blind, immobile except for its gaping mouth. As if that's not enough fragility, the baby bird's bowl-shaped nest sits on the ground — the same ground where herds of 800-pound cattle may graze. But the threat implied by […]
October 11, 2014
Small-Scale Science
Little kids have a lot in common with hummingbirds. Both are small in size, quick in motion and fond of sugar. Plus, kids think hummingbirds are cool. So pairing Oregon schoolchildren with the feisty, orange-throated hummers that share their Willamette Valley habitat seemed like a scientific and educational slam-dunk to ornithologist Matt Betts, a researcher […]
October 10, 2014
The GMO Conundrum
Oregonians will go to the polls on November 4 to decide whether or not to require prominent labels on food containing ingredients made from genetically modified organisms, or GMOs. The issue of labeling has been around for years, and — déjà vu! — Oregonians have even voted on it before. But the rhetoric has heated […]
October 10, 2014
Arrested Development
Genetic engineering has become a valuable scientific tool. It has enabled us to gain tremendous insight into the mechanisms of plant reproduction, disease resistance and other useful traits. However, commercial use of this technology has not lived up to expectations and has created serious hurdles for plant breeders. That in turn hampers genetic progress and […]
October 7, 2014
University of Alaska Joins Wave Energy Partnership
Wave energy researchers will focus on the tidal inlets and coastal waves of Alaska as a result of a $4 million grant from the U.S. Department of Energy. Until now, the Northwest National Marine Renewable Energy Center has been a partnership of Oregon State University and the University of Washington. "Alaska has an enormous energy […]
October 6, 2014
Aspen Recovery in Yellowstone Spurred by Wildlife Shifts
Wildlife in Yellowstone National Park is undergoing dramatic shifts with consequences that are beginning to return the landscape to conditions not seen in nearly a century. In the park's northeast section, elk have decreased in number in their historic winter range in the Lamar Valley and are now more numerous outside the park. Aspen recovery […]
August 14, 2014
Oceanography Boot Camp
If they had come home early, you wouldn't have been surprised. Half of them got seasick. Equipment failed. And the weather changed unexpectedly. But last April, 11 Oregon college students from three institutions — Oregon State University, the University of Oregon and Clatsop Community College — stuck it out for four days at sea on […]
May 28, 2014
Learning to Dive
It seemed that Kyle Neumann had a dream job: video broadcasting for the Portland Timbers. But something kept nagging at him. "For me, it just wasn't fulfilling a higher purpose," says the Oregon State University senior. He wanted to use his video storytelling skills, he decided, not for professional sports but for Planet Earth. First, […]
May 28, 2014
Trial by Fire
Few places are as hot as 6,000 degrees Centigrade: the surface of the sun, the center of the Earth, the heart of a laboratory device at Oregon State University. In the lab, this is the temperature of a kind of flame produced when argon gas flows through an intense electromagnetic field. Appropriately, the part of […]
May 24, 2014
Cows Show Stress
Livestock that have encountered wolves experience stress that may affect their health and productivity.
April 18, 2014
Taking the Measure of Seals and Those Who Study Them
In Antarctica, when you sedate a 1,000-pound Weddell seal, it can take a while for the animal to settle down.
January 24, 2014
Survivors from the Depths of Time
As one of the "first foods" of Northwest Indians (along with salmon, elk, huckleberries and camas bulbs) lamprey hold a place of high honor in tribal culture. But outside Indian culture, Pacific lamprey have a PR problem.
January 24, 2014
The Warsaw Discourses
Gregg Walker is making his way toward the University of Warsaw where the Global Landscapes Forum is being held as part of the United Nations climate change negotiations for 2013. The Oregon State University professor has been attending these international climate conferences for half a decade.
January 24, 2014
High Beams
For a place that takes pictures with what amounts to controlled bursts of lightning, the lab is quiet, almost hushed. Standing in the entrance to Oregon State University's Electron Microscopy Facility (EMF), you might hear researchers' soft voices as they discuss the best way to see pollen on a bee's tongue or to look at […]
January 23, 2014
Carnivores in Retreat
In ecosystems around the world, the decline of large predators such as lions, wolves and cougars is changing the face of landscapes from the tropics to the Arctic. An analysis of 31 carnivore species shows how threats such as habitat loss, persecution by humans and reductions in prey combine to create global hotspots of carnivore […]
January 23, 2014
Viral Diagnostics
Rocky Baker, supervisor of the virology lab in the Oregon State University Veterinary Diagnostic Laboratory, identified this influenza virus in pet ferrets whose owner had come down with the flu. Ferrets are susceptible, he says, and the owner was concerned that his animals became sick after contact with a family member who had influenza symptoms. […]
January 23, 2014
Through the Needle
On the surface of a Douglas-fir needle, the spore of a fungal pathogen, Phaeocryptopus gaeumannii, germinates and sends forth threads (hyphae). It matures into an organism that will grow inside the needle and reproduce. By interfering with the tree's ability to exchange air and water, it shuts down photosynthesis. Thus starts a disease known as […]
January 23, 2014
Oysters on Acid
The oceans are about 30 percent more acidic than they were a century ago, and scientists are beginning to understand the consequences for marine ecosystems. Oysters may provide an early warning of what's to come. George Waldbusser, a biogeochemist in the College of Earth, Ocean, and Atmospheric Sciences, and Elizabeth Brunner, a master's student, conducted […]
January 23, 2014
Nanocrystals for Solar
In Alex Chang's lab in the School of Chemical, Biological and Environmental Engineering, researchers arrange atoms in precise patterns to create materials with novel electrical and heat-transfer properties. Chang and his colleagues use electron microscopy to visualize and analyze structures that are often only a few atoms thick. "The EM facility is very important for […]
January 23, 2014
Illuminating Plankton
Consuelo Carbonell-Moore has made it her life's work to document the diversity of one of the ocean's most abundant life forms: dinoflagellates, a type of plankton. These organisms are no mere bystanders in marine ecosystems. Some produce life-giving oxygen. Others influence the formation of coral reefs. In coastal waters, they can bloom as "red tides" […]
January 23, 2014
Proof of Pollination
As honeybees pick up pollen and nectar, they pollinate about one-third of the plants in the human diet. "Growers rent honeybees to pollinate their crops, and we are taking a close look to see what kinds of pollen the bees are actually collecting," says Sujaya Rao, entomologist in Crop and Soil Science. Using a scanning […]
January 22, 2014
International Imperative in Science
My research career took me to the waters off Africa, South America and Central America. I found the experience of working with colleagues from many nations to be exciting, and I learned a lot about the scientific challenges we were addressing. In retrospect, I realize I learned a lot more about being a good citizen […]
January 22, 2014
Shoring Up Our Coasts
As a scholar in environmental communications, Miriah Russo Kelly is digging into the interpersonal dynamics of collaboration and cooperation among people who may share little in common except locale — fishermen and hotel managers, loggers and grocers, political leaders and homeowners, climate scientists and climate skeptics.
January 22, 2014
Lamprey Brain Trust
"The situation for Pacific lamprey is bad and getting worse," says OSU fisheries biologist David Noakes, director of the Oregon Hatchery Research Center in Alsea. "We have enormous gaps in our knowledge of even the most basic aspects of life history, ecology and behavior of our native lamprey." To jumpstart the filling of those gaps, […]


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Video Industry News Video Company News Technology Industry News Technology Company News Novelty Industry News Novelty Company News Gay Industry News Gay Company News Legal Industry News All Company News
Director: Uncredited
Company: Lesbian Provocateur
Distribution Companies: Digital Sin
DVD Extras: Trailer(s)
Cast: Cindy Hope, Wivien (I), Madison Parker, Betty Saint, C.J., Jenna Lovely, Sensual Jane, Jessica Moore, Peaches (II) (Hungarian), Kiesha Kane, Janine Rose, Liza Del Sierra, Debbie White, Blue Angel
Genre: All-Girl, Foreign All-Sex, Specialty
Specialty Type: Wrestling
General Information You've got front seats at the Nude Fight Club, so here's your chance to meet 14 sexy & provocative fighters. These girls love skin-to-skin contact, and there's plenty of it to be found here! So feel the heat of these passionate battles, because these girls are baring it all at the Nude Fight Club!


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Promote breast cancer awareness day after day with this logo imprinted Breast Cancer Ribbon Shaped Stick Up Custom Calendar.
Add a touch of inspiration to each day with this imprintable custom calendar.
Reduced price promotional products on sale at ePromos. Save money on your next marketing campaign or event with these cheap promotional items.


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Recording of my cat as she purrs. Her purr is deep and resonate. Audio taken from a video of my ...
Recorded using a Zoom H1 and a Rode Videomic.
Eerie (bad :D) singing recorded with reverb and highered pitch.
this is the eerie sound of a record skipping on a broken turntable.
A blues lick from the A Minor Pentatonic scale. Played with a slightly bouncy feel in the style of Jimi ...
A very short clip of a young girl laughing. Recorded with built-in macbook pro 2010 microphone; processed to remove noise.
Palpitation, heartbeat...
An acidental heartbeat i made
A casual take (with Camcorder JVC-520)…Trying to get out of traffic at the end of WRC Super-Prime at ChateauCordoba Stadium.
Censorship bleep created in Audacity in .WAV format so it's uncompressed and of the highest quality. 30 seconds should be ...
Modified human imitation of a mouse. Made by pressing the upper teeth against the bottom lip and sucking.
A sample horror-scream sound.
Another scary scream.
scary spimd
This is the sound that played when I tried to open a picture as Raw Data in Audacity.


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Small business owners and sole proprietors need business credit cards to finance various purchases and to track expenses. In addition, business owners may want to use their cards to earn valuable rewards.
The Citi AT&T Universal Business Rewards Card offers reasonable interest rates and a solid rewards program that allows business owners to earn extra points for purchasing gas, office supplies, professional services, and purchases from AT&T while easily tracking business expenses.
Key Features


text:
About Cotecna
Cotecna Services
Cotecna Tools
Cotecna News & Media
Call or email us!
Cotecna offers Testing, Inspection and Certification (TIC) services including Verification of Conformity (VOC) and Customs trade solutions: destination inspection, cargo tracking, scanner integration projects.
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Just got my page up and running. Not much there yet, but thought I would give everyone a gander. If you are into poetry, short stories, etc, feel free to leave comments.
Just got my page up and running. Not much there yet, but thought I would give everyone a gander. If you are into poetry, short stories, etc, feel free to leave comments.
Well, if I can be blunt, I think the font you're using as your main text is extremely difficult to read. Perhaps a cleaner font would make this easy to understand, and reduce viewer's eyestrain. Just a thought.
Apart from that the colour and design look pretty sweet. Well done!!
Rodney T
[sig moderated]
Site closed. If a mod could remove link/post ,that would be great.
Do you have it posted elsewhere? I would have love to have taken a look! :-(
Your interest is much appreciated :) Unfortunately I don't have my work posted elsewhere at the moment. I am just taking some time off to focus entirely on publishing, so not much time for maintaining a site I am afraid. Hopefully I will have a site up and running again in the near future though as it was a fun way to touch base with others.
clicked your link above and end up at your root directory (no files) with another sub-directory listed (no blog)???
[signature moderated Please read the Forum Rules]
Please see above posts. Site is closed. Just trying to get a mod to delete this post/link if possible.
This is a pretty happening thread for no site. Cool!
Yeah, yeah, yeah...figures, as soon as I close my site, everyone is interested. :p So does anyone know how to get the mods to at least remove the link? It's giving me some troubles with the google.
This topic has been closed to new replies.


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Great Job New Direction - Especially the Precious Metals Team
I wanted to invest in precious metals and found a way to rollover money from a 401K into an IRA. Due to before and after tax money, two accounts needed to be opened. In most of my dealings with companies, they usually fall short and I am disappointed. In the case of New Direction, they not only met my expectations but far exceeded them. They have always been outstanding in their timely response and their communication about every step of the process has been exceptional. I recommended New Direction to a friend and he has had a similar exceptional experience. I am quick to complain (which I do a lot), but I am also one to step up and commend exceptional service. Great Job New Direction, especially the Precious Metals team.
My IRA was able to purchase leveraged real estate
My IRA was able to purchase leveraged real estate by using administration services provided by New Direction IRA, Inc. I have also assisted my clients in putting together private placement investments for use by their IRA accounts and found New Direction to be helpful and responsive to my needs and the needs of my clients.
Want to submit a testimonial or investment success story?
A big thanks to you all at New Direction IRA Inc.
I am a Florida resident and I appointed NDIRA as my administrator to purchase a local property which I wished to hold in my IRA as an investment income property. They handled the transaction with ease and I was able to direct the transaction by internet through their secure site portal. My husband who saw how easy it was then also appointed NDIRA as his adminstrator for a similar transaction. We have both been able to remove our IRA investments from the volatile stockmarket and put the IRAs to work in a more tangible Property Market. A big thanks to you all at New Direction IRA Inc.
I Liked the Simplicity New Direction Offered and the Fee Structure!
I have worked with New Direction IRA for more than two years. I initially moved my IRA funds into a self directed account after learning about it at a local real estate investment club meeting. I had been looking for an alternative to the low cost mutual funds and ETF's that I had been investing in and that were becoming increasingly risky in my view.
I also felt that because I had some expertise in the field of real estate it made sense to open up my IRA to potential real estate investing opportunities as a way to increase my future holdings for retirement. My actual plan evolved into buying many investment properties (both residential and commercial), and buying the properties using leverage as well.
My target date to be "financially independent" is 2019 when I will be 55 years old. Over the past two years I have been able to average well over 25% per year return, including the monthly cash flows from the rental properties as well as appreciation, which is overlooked by many investors. Once I have paid the properties off, my returns should be consistently greater than 30% based on my historical numbers.
When I do start taking distributions, I intend to draw only from the positive monthly cash flows that the rental properties throw off while the actual properties themselves will hopefully continue to appreciate over time, continuing to grow tax deferred within my self directed IRA.
Finally, I would say that prior to setting up my self directed IRA with New Direction, I had researched more than 10+ other firms offering a similar product. I liked the simplicity New Direction offered and the fee structure. New Directions fees are very reasonable in my view and fit well within my overall strategy of accumulating real estate investment properties within my IRA.
The staff really took the time
My experience with New Direction IRA has been great! They have been very helpful to me, explaining the process and details of how to invest using an self directed IRA. The staff really took the time with me and I am happy with their service in every way. I say "Get with the times and take control of your retirement investments!"
It has taught me how to own the outcome of my own future
In 2005 I retired from my employer of 33 years. For the first time, I had complete control of my IRA and how I wanted to invest it. I spoke to two different brokers and shared with each that I really wanted to invest in Real Estate, but each showed me the 30 average for stocks and mutual funds - and told me that real estate wasn't for me. I went ahead and set up a plan with one of these firms. We had projected that I would double my money in 7 years (at a rate of return of 10.5%) and with those results I was sitting good to fully retire after those 7 years, with enough money to meet my retirement goals.
By spring of 2008, my projected 10.5% looked more like 2% and I was not on track to be prepared for retirement in time for my 2013 birthday as planned. I had a share of the IRA in contracts that had come due, and I did not renew those contracts. Good timing for me, while I watched the remaining funds dwindle with the 2008 crash, these funds were sitting in cash. At that time I had been investigating different investment opportunities and venture capital groups. I had heard about New Direction, and started investigating the self directed approach. It seemed like a good fit.
I opened an account with New Direction, and in the spring of 2009, "Uncle IRA" started purchasing homes with our IRA funds. Tina, our Asset Acquisition Manager at New Direction, has been very helpful teaching us how to follow the IRS rules and New Direction as a group does a great job making sure all transactions are compliant with IRS rules and regulations.
In the economic times we are in, the thing I like most about New Direction and the Self Directed IRA concept is that it has taught me how to own the outcome of my own future. I feel I had two choices - become dependent on government funding during retirement, or grow my retirement to be self-sufficient. I have a motto to inspire me, stuck on my Worksheet - Press On - Be Deliberate! Or spelled out - Build a detailed plan - then forge ahead and execute.
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New Direction has been absolutely awesome
Someone mentioned at a dinner party that they had a friend who was considering purchasing a second home using their IRA. I "Googled" IRA to purchase real estate and found NDIRA. New Direction has been absolutely awesome. Tina and Amber have been the "dream team" for me. Tina really went out of her way to help get this account set up so that I could close on my Beach House in a time frame that was suitable to the seller. Amber has been great as well. She has been convenient any time I needed help or had questions and has been professional the whole time. I have already talked to some of my friends about them using their IRA's like I did. Thanks New Direction!
Knowledgeable about complicated real estate transactions
Three years ago, I was looking for a self directed IRA where I could take advantage of some good real estate investments. I went online and found only a few that interested me. After discussing accounts with those who offered to administer real estate transactions, I chose NDIRA, Inc. Their program was simple to learn, their people are knowledgeable about complicated real estate transactions, and are timely in processing the transactions. I would refer anyone to use NDIRA for a self directed IRA.
It's nice having people who care
I found out about New Direction from a friend that introduced me to the program. New Direction's paperwork process was efficient and the staff was easy to work with when I had questions. I've told lots of my friends about the success of my new IRA investments and the service! It's nice having people who care to talk with when I have a problem or question - this is my big thumbs up to New Direction. Thank you!
A big thank you to New Direction
A big THANK YOU to New Direction for helping me facilitate my IRA purchasing a parcel of land. You guys were patient and helpful to both me and the closing attorney. It has been a pleasure to work with you.
Thank you and your office for all of your help
Just a quick note to thank you and your office for all of your help with the two real estate purchases last week. Everything went smoothly and we're now the proud owners of a couple of rental houses. Anyway, if you ever need an endorsement, consider me a volunteer.
I recommend New Direction to all my clients these days
Are you frustrated by the performance of your retirement program? With the help of New Direction, I stopped leaving my retirement savings up to no name corporate boards that had everyone else's interest but mine. As a Realtor, I help clients succeed with buying and selling properties every day. Why couldn't I put my savings to work...for me?! I had heard about New Direction and their Self Directed IRA programs, but thought it was either too good to be true or just too complicated. Not only did they walk me through the process, with amazing patience and great customer service skills, Tina Garland helped me with my first purchase as well. These guys were amazing. What I first thought would be like splitting an atom turned out to be a walk in the park. I recommend New Direction to all my clients these days. Thank you New Direction IRA.
Real Estate Investments
New Direction is great. They help us a lot with our real estate investments.
Great Webinars
New Direction offers great webinars to help educate any investor about the benefits of self directed IRA's.
Don't rely on the
Don't rely on the "old" ways... these guys are giving you the opportunity to make a real difference for your retirement!!!


text:
Hi Does having about 100 sites with apache dramatically slow down response time compared to having just one or two?
my vhosts.conf is huge
Edit: no, i mean purely the part of apache that reads through the vhosts.conf file and finds the record for the domain, and what user/where its "folder" is. i don't mean bandwidth etc. just does having 100+ sites mean it takes considerably longer (ie, would it have an impact on a server doing 60-70k uniques a day) than just having 1 record in the vhosts.conf
(btw, when i talk about vhosts, that is how my server deals with having multiple domains on one server. i don't know if this is normal but from a google it looks like it is)


text:
Chicago Tribune
When I Was Mortalby Javier Marias
View All Available Formats & Editions
Victims of mistaken identity, sponging relatives, amateur sleuths, eavesdroppers, professional liars, assassins, and failed bodyguards populate the short stories in When I Was Mortal. Plots turn on curious exigencies--a/i>
- Overview
- Editorial Reviews
- Product Details
- Related Subjects
- Read an Excerpt
- What People Are Saying
- Meet the author
A dozen stories by Javier Marías, "the most subtle and gifted writer in contemporary Spanish literature" (The Boston Globe).
Victims of mistaken identity, sponging relatives, amateur sleuths, eavesdroppers, professional liars, assassins, and failed bodyguards populate the short stories in When I Was Mortal. Plots turn on curious exigencies--a woman about to star in her first porn film; a night doctor who adds new meaning to "specialist"; a ghost whose neglect is greatly resented.
Editorial Reviews
Chicago Tribune
New York Times Book Review
"A refreshing discovery... [they] should be welcomed here like a bracing tonic." Chicago Tribune
"Dazzling.... Javier Marías writes with elegance, with wit and with masterful suspense." The Times Literary Supplement
"His prose demonstrates an unusual blend of sophistication and accessibility." —The New Yorker
Product Details
- 9780307951090
- Publisher:
- Knopf Doubleday Publishing Group
- Publication date:
- 04/23/2013
- Series:
- Vintage International
- Sold by:
- Random House
- Format:
- NOOK Book
- Pages:
- 176
- File size:
Read an Excerpt
Chapter One
The Night Doctor
For LB, in the present,
And DC, in the past
Now that I know my friend Claudia is a widow following her husband's death from natural causes I keep remembering one particular night in Paris six months ago: I had left at the end of a dinner party for seven in order to accompany one of the guests home she had no car, but lived close by, fifteen minutes there and fifteen minutes back. She had struck me as a somewhat impetuous, rather nice young woman, an Italian friend of my hostess Claudia, who is also Italian, and in whose Paris apartment I was staying for a few days, as I had on other occasions. It was the last night of my trip. The young woman, whose name I cannot now remember, had been invited for my benefit, as well as to add a little variety to the dinner table or, rather, so that the two languages being spoken were more evenly spread.
During the walk, I had to continue muddling through in my fractured Italian, as I had during half the dinner. During the other half, I had muddled through in my even more fractured French, and to tell the truth I was fed up with being unable to express myself correctly to anyone. I felt like compensating for this lack, but there would, I thought, be no chance to do so that night, for by the time I got back to the apartment, my friend Claudia, who spoke fairly convincing Spanish, would already have gone to bed with her ageing giant of a husband, and there would be no opportunity until the following morning to exchange a few well-chosen andclearly enunciated words. I felt the stirring of verbal impulses, but I had to repress them. I switched off during the walk: I allowed my Italian friend's Italian friend to express herself correctly in her own language, and I, against my will and my desire, merely nodded occasionally and said from time to time: "Certo, certo," without actually listening to what she said, weary as I was with the wine and worn out by my linguistic efforts. As we walked along, our breath visible in the air, I noticed only that she was talking about our mutual friend, which was, after all, quite normal, since, apart from the dinner party for seven that we had just left, we had nothing much else in common. Or so I thought. "Ma certo," I kept saying pointlessly, while she, who must have realized I wasn't listening, continued talking as if to herself or perhaps out of mere politeness. Until suddenly, still talking about Claudia, I heard a sentence which I understood perfectly as a sentence, but not its meaning, because I had understood it unwittingly and completely out of context. "Claudia sarà ancora con il dottore," was what I thought her friend said. I didn't take much notice, because we were nearly at her door, and I was anxious to speak my own language again or at least to be alone so that I could think in it.
There was someone waiting in the doorway, and she added: "Ah no, ecco il dottore," or something of the sort. It seems the doctor had come to see her husband, who had been too ill to accompany her to the dinner party. The doctor was a man of my age, almost young, and he turned out to be Spanish. That may have been why we were introduced, albeit briefly (they spoke to each other in French, my compatriot in his unmistakably Spanish accent), and although I would have happily stayed there for a while chatting to him in order to satisfy my longing for some correct verbification, my friend's friend did not invite me in, but instead bade me a hasty goodbye, giving me to understand or saying that Dr. Noguera had been there for some minutes waiting for her. My compatriot the doctor was carrying a black case, like the ones doctors used to have, and he had an old-fashioned face, like someone out of the 1930s: a good-looking man, but gaunt and pale, with the fair, slicked-back hair of a fighter pilot. It occurred to me that there must have been many like him in Paris after the Spanish Civil War, exiled Republican doctors.
When I got back to the apartment, I was surprised to see the light still on in the study, for I had to pass by the door on my way to the guest room. I peered in, assuming that it had been left on by mistake, and was ready to turn it off, when I saw my friend was still up, curled in an armchair, in her nightdress and dressing gown. I had never seen her in her nightdress and dressing gown before, despite, over the years, having stayed at her various apartments each time I went to Paris for a few days: both garments were salmon pink, and very expensive. Although the giant husband she had been married to for six years was very rich, he was also very mean, for reasons of character, nationality or age a relatively advanced age in comparison with Claudia and my friend had often complained that he only ever allowed her to buy things to further embellish their large, comfortable apartment, which was, according to her, the only visible manifestation of his wealth. Otherwise, they lived more modestly than they needed to, that is, below their means.
I had had barely anything to do with him, apart from the odd dinner party like the one that night, which are perfect opportunities for not talking to or getting to know anyone that you don't already know. The husband, who answered to the strange and ambiguous name of Hélie (which sounded rather feminine to my ears), I saw as an appendage, the kind of bearable appendage that many still attractive, single or divorced women have a tendency to graft onto themselves when they touch forty or forty-five: a responsible man, usually a good deal older, with whom they share no interests in common and with whom they never laugh, but who is, nevertheless, useful to them in their maintaining a busy social life and organizing dinners for seven as on that particular night. What struck one about Hélie was his size: he was nearly six foot five and fat, especially round the chest, a kind of Cyclopean spinning top poised on two legs so skinny that they looked like one; whenever I passed him in the corridor, he would always sway about and hold out his hands to the walls so as to have something to lean on should he slip; at dinners, of course, he sat at one end of the table because, otherwise, the side on which he was installed would have been filled to capacity by his enormous bulk and would have looked unbalanced, with him sitting alone opposite four guests all crammed together. He spoke only French and, according to Claudia, was a leading light in his field the law. After six years of marriage, it wasn't so much that my friend seemed disillusioned, for she had never shown much enthusiasm anyway, but she seemed incapable of disguising, even in the presence of strangers, the irritation we always feel towards those who are superfluous to us.
"What's wrong? Still awake?" I said, relieved finally to be able to express myself in my own language.
"Yes, I feel really ill. The doctor's coming."
"At this hour?"
"He's a night doctor, he's on call. I often have to get him out at night."
"But what's wrong? You didn't mention anything to me."
Claudia dimmed the lamp that stood by the armchair, as if she wanted the room to be in darkness before she replied, or else did not want me to catch some involuntary expression on her face, for our faces, when they speak, are full of involuntary expressions.
"It's nothing, women's problems. But it really hurts when I get it. The doctor gives me an injection to ease the pain."
"I see. And couldn't Hélie learn to do that for you?"
Claudia gave me an unequivocally wary look and lowered her voice to answer that question, though she hadn't lowered it to answer the others.
"No, he can't. His hands shake too much, I don't trust him. If he gave me the injection I'm sure it wouldn't do me any good, or else he'd just get all mixed up and inject something else into me, some poison. The doctor they usually send is very nice and, besides, that's what they're there for, to come to people's apartments in the early hours of the morning. He's Spanish by the way. He'll be here any moment."
"A Spanish doctor?"
"Yes, I think he's from Barcelona. I assume he has French nationality, he must have in order to practice here. He's been here for years."
Claudia had changed her hairstyle since I left the apartment to walk her friend home. Maybe she had merely let her hair down prior to going to bed, but it looked to me as if she had done her hair specially, rather than undone it at the end of the day.
"Do you want me to keep you company while you wait or would you rather be alone if you're in pain?" I asked rhetorically since, having found her still up, I wasn't prepared to go off to bed without satisfying my desire to have a chat and a rest from those other abominable languages and from the wine drunk during the evening. Before she had a chance to reply, I added: "Your friend's very nice. She said her husband was ill; the local doctors are in for a busy night."
Claudia hesitated for a few seconds and it seemed to me that she again looked at me warily, but said nothing. Then she said, this time without looking at me:
"Yes, she's got a husband too; he's even more unbearable than mine. Hers is young, though, just a bit older than her, but she's had him for ten years now and he's just as mean. Like me, she doesn't earn very much with her job, and he even rations out the hot water. Once he used his old bath water to water the plants, which died soon after. When they go out together, he won't even buy her a coffee, they each pay for themselves, so that sometimes she goes without and he has a full afternoon tea. She doesn't earn that much, and he's one of those men who thinks that the person who earns less in a marriage is inevitably taking advantage of the other. He's obsessed with it. He monitors all her phone calls, he's fitted the phone with a device that stops her calling anywhere outside of the city, so that if she wants to speak to her family in Italy she has to go to a pay phone and use coins or a card."
"Why doesn't she leave him?"
Claudia didn't reply at once.
"I don't know; for the same reason I don't, although my situation isn't as bad as hers. I suppose it's true that she does earn less, I suppose she does take advantage of him; I suppose they're right, these men who are obsessed with the money they spend or manage to save with their low-earning wives; but that's what marriage is about, everything has its compensations and it all evens out in the end." Claudia dimmed the light still further, so that we were sitting in almost complete darkness. Her nightdress and dressing gown seemed to glow red, an effect of the growing dark. She lowered her voice still further, to the point where it became a furious whisper. "Why do you think I get these pains, why do you think I have to call a doctor out to give me a sedative? It's just as well it only happens on nights when we give dinners or parties, when he's eaten and drunk and enjoyed himself. When he's seen that others have seen me. He thinks about other men and about their eyes, about what others don't know about, but take for granted or assume, and then he wants to make it reality, not just taken for granted or assumed or unknown. Not imaginary. Then it isn't enough for him just to imagine it." She fell silent for a moment and added: "That great lump of a man is sheer torment."
Although our friendship went back a long way, we had never exchanged this kind of confidence. Not that it bothered me, on the contrary, there's nothing I like more than being privy to such revelations. But I wasn't used to it with her, and I may have blushed a little (not that she would have seen me) and I answered awkwardly, perhaps dissuading her from continuing, the exact opposite of what I wanted:
"I see."
The doorbell buzzed feebly, just loud enough to be heard, the way you ring at the door of a house where people are already alerted or expecting you to call.
"It's the night doctor," said Claudia.
"I'll leave you then. Goodnight, and I hope you feel better soon."
We left the study together, she went into the hall and I in the opposite direction, towards the kitchen, where I thought I might read the newspaper for a while before going to bed, for at night the kitchen was the warmest room in the house. Before turning the corner of the corridor that would take me there, though, I paused and looked back towards the front door that Claudia was opening at that very moment, obscuring with her salmon-colored back the figure of the doctor who had just arrived. I heard her say to him in Spanish: "Buenas noches," and all I could see, in the doctor's left hand, sticking out from behind my Italian friend's body, was a bag identical to that carried by the other doctor to whom I had been introduced at the door by her friend also Italian whose name I can't remember. The doctor must have come by car, I thought.
They closed the front door and walked down the corridor without seeing me, with Claudia in front, and then I headed for the kitchen. There I sat down and poured myself a gin (ridiculous, mixing drinks like that) and opened the Spanish paper I had bought that afternoon. It was from the previous day, but for me the news was still fresh.
I heard my friend and the doctor go into the children's room, the children were spending the weekend with other children in someone else's house. The room was immediately opposite the kitchen, on the other side of a broad corridor, so, after a few moments, I moved the chair I was sitting on so that I could just see the door of the room out of the corner of my eye. The door was ajar, they had switched on a very dim light, as dim, I said to myself, as the one that had lit the study while she and I were talking and she was waiting. I couldn't see them, I couldn't hear anything either. I went back to reading my newspaper, but, after a while, I looked up again because I sensed a presence in the doorway of the door that stood ajar. And then I saw the doctor, in profile, holding a syringe in his left hand. I only saw him for an instant, and since he was standing against the light, I couldn't see his face. I noticed he was left-handed: it was that moment when doctors and nurses raise the syringe in the air and press down the plunger, just a little, to make sure that the liquid comes out and there's no danger of any blockage or, more seriously, no danger of injecting air. That's what the nurse, Cayetano, used to do in my house when I was a child. After performing this action, the doctor stepped forward and again disappeared from my field of vision. Claudia must have been lying down on one of the children's beds, which was probably where the light was coming from, too faint for me but sufficient for the doctor. I assumed he would inject her in the bottom.
I returned to my newspaper and a long time passed, too long, before either she or the Republican doctor were once again framed in the doorway. Then I had the vague feeling that I was being nosy and it occurred to me that perhaps they were actually waiting for me to go to my room in order to come out and say goodbye. It also occurred to me that, immersed as I had been in reading an article about some sporting controversy, they might have quietly slipped out of the room without my noticing. Trying not to make any noise so as at least not to wake old Hélie, who would have been asleep for some time, I got up to go to bed. Before leaving the kitchen with my newspaper under my arm, I switched off the light, and that switching off of the light and my momentary stillness (the moment before taking a first step down the corridor) coincided with the reappearance in the doorway of the two figures, that of my friend Claudia and that of the night doctor. They paused on the threshold, and from my place in the darkness, I saw them peering in my direction, or so I thought. During that moment, what they saw was the extinguished kitchen light, and since I remained motionless, they probably assumed that I had gone off to my room without their noticing. If I allowed them to believe such a thing, if I, in fact, remained there motionless after seeing them, it was because the doctor, again standing against the light, once more raised the syringe in his left hand, and Claudia, in her nightdress and dressing gown, was clinging onto his other arm as if to instill him with courage by her touch or else restore his composure by her breathing. Thus, arm in arm, bound together by what was about to happen, they moved out of the children's room, and I lost sight of them, but I heard the door of the master bedroom opening, the bedroom in which Hélie would be sleeping, and I heard it close. I thought that perhaps, immediately after that, I would hear the doctor's footsteps, he having left Claudia in her room in order to leave the house, now that his medical mission had been fulfilled. But that isn't what happened, the penultimate thing I heard that night was the closing of the master bedroom door, which the night doctor had also entered, very quietly and holding a syringe in his left hand.
With great care (I took off my shoes), I walked down the corridor to my room. I undressed, got into bed and finished reading the newspaper. Before turning out the light, I waited a few seconds and it was in those brief seconds of waiting that I at last heard the front door and Claudia's voice saying goodbye to the doctor in Spanish: "See you in a fortnight then. Goodnight, and thanks." The truth is that I still felt like speaking a little more of my own language on that night on which I had twice missed the opportunity of doing so with my compatriot the doctor.
I was going back to Madrid the following morning. Before leaving, I had time to ask Claudia how she was, and she said she was fine, that the pains had gone. Hélie, on the other hand, was indisposed after the various excesses of the previous night and relayed that he was sorry not to be able to say goodbye to me himself.
I spoke to him on the phone after that (that is, he picked up the phone on one occasion when I called Claudia from Madrid in the months that followed), but the last time I saw him was when I left his apartment that night, after the dinner for seven, to walk the Italian friend, whose name I cannot remember, back to her apartment. Precisely because I cannot remember her name, I do not know if the next time I go to Paris, I will dare to ask Claudia how she is, because now that Hélie is dead, I wouldn't want to run the risk of finding out that perhaps she too has become a widow since my departure.
What People are saying about this
(W.G. Sebald)
Meet the Author
Javier Marías was born in Madrid in 1951. He has published ten novels, two collections of short stories and several volumes of essays. His work has been translated into thirty-two languages and won a dazzling array of international literary awards, including the prestigious Dublin IMPAC award for A Heart So White. He is also a highly practiced translator into Spanish of English authors, including Joseph Conrad, Robert Louis Stevenson, Sir Thomas Browne and Laurence Sterne. He has held academic posts in Spain, the United States and in Britain, as Lecturer in Spanish Literature at Oxford University.
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*Additional licenses are available for an annual subscription fee. Contact us for details.
- Jo Morris, Compliance Training and Communications Manager, Hill Dickinson, LLP


text:
mini player High Quality mp3 feed
mini player Mobile Quality mp3 feed
Late night freeform eclectic show
12:00 am - 03:00 am MT
Early morning freeform eclectic show
03:00 am - 05:30 am MT
August 1, 2014
Larry Keel is described by some reviewers as the most powerful, innovative and all-out exhilarating acoustic flatpicking guitarist performing today. Keel has absorbed the best lessons from his Bluegrass family upbringing, both sides deeply steeped in the rich mountain music culture and heritage of Southwest Virginia.
Larry Keel in will be playing an intimate set at the Gold Hill Inn on Friday August 1st.
Artist: Larry Keel Experience
Venue: Gold Hill Inn


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text:
What I Say When I Play? EP (Incl. Cabanne Remix)
- Artists Cabanne, Minimono
- Release Date 2008-12-03
- Labels Tenax Recordings
- Catalog TNX030
- Description Second colourful ep for the Minimono guys on Tenax! Fabio della Torre and Ennio Colaci after releases on Tuningspork, Ethique, Loveletters from Oslo, bring us with this record an original mix between deep and funk, with good dancefloor appeal, together with the excellent remix from Cabanne.


text:
Definition of bupkis in English:
nounUS informal
Nothing at all: you know bupkis about fundraising
More example sentences
- But this is a guy who has bupkis to say when a fellow Christian hypocrite lies to the voters on a daily basis about matters of life and death, so I guess I shouldn't be surprised.
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Pub Date: September 2006
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Pages: 104
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Will be arraigned today in Toledo Municipal Court.
Will share thoughts from county's Drug Abuse Response Team.
A man was shot and killed Wednesday night in South Toledo. Isaiah Austin, 26, of Toledo, was pronounced dead at the scene, Toledo police said. Police responded to the 1200 block of South Avenue about 9:05 p.m. and found Austin in his car with at
An unidentified dead man was found in a vacant house in the 400 block of White Street about 11:30 a.m. Thursday. Police said they were unsure if the deceased committed suicide or was a homicide victim. Police told a couple that owns the building
No deal on how costs will be divided; city to miss Friday payment.
Lucas County sheriff will travel to Washington next week.
Mecca Canty, 21, sentenced for endangering children.
Isaiah Austin, 26, was pronounced dead at the scene on South Avenue.
Bond set at $1.75M for James T. Moore, previously convicted of involuntary manslaughter.
Body found in 400 block of White Street this afternoon.


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Correspondence to: Hyunjin Shin, PhD, Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02215, United States. email@example.com
Telephone: +1-617-5518730 Fax: +1-617-5517871
Current progress in epigenetic research supports the view that diet and dietary components are important in cancer etiology by enhancing or inhibiting carcinogenesis. Since diet and dietary factors may significantly contribute to the causation and progression of many cancers, it is important to find the molecular mechanisms of action of such dietary factors for cancer prevention and treatment. Recently, the role of epigenetic mechanisms in the cancer development and progression has attracted more attention as additional evidence along with traditional DNA sequence based mechanisms such as mutations and structural re-arrangements. Such an increasing interest in cancer epigenetics has also accelerated the development and application of molecular assays and tools for DNA methylation detection and histone modification enrichment analysis. In this paper, key assays and methods for epigenetic research are reviewed and discussed in terms of their utility and usability. In addition, more advanced methods for genome-wide analysis are introduced as part of upcoming research trends and directions.
Diet and dietary factors play an important role in many biological processes and are also involved in the regulation of pathological progressions including cancers. Several epidemiological and preclinical studies suggested that increased intake of bioactive dietary components may modulate cancer risk. Many studies provide compelling evidence that part of the anti-cancer properties contributed to several bioactive dietary components may relate to modulation of epigenetic process including DNA methylation and histone protein modifications. Here, we provide a brief overview of dietary modulation of DNA methylation and histone modifications and its potential role in cancer prevention. Also, we will discuss several new epigenetic methods to help understand the effect of dietary factors on epigenetic modifications.
The growing interest in the role of epigenetics in cancer came from the demonstration that epigenetic modifications are involved in tumor development and progression. Epigenetics can be defined as phenomena that alter the expression of the information in the genome at the transcriptional, translational, or posttranslational level without change in DNA sequence[1,2]. Epigenetic information is maintained to preserve cellular identity in normal cells, while cancer cells are characterized by profound alteration of epigenetic regulation[3-7]. The overall disruption of epigenetic phenomena is a common feature of all human tumors and includes alteration of DNA methylation and histone modification patterns[8]. DNA methylation patterns of neoplastic cells have been recognized as being substantially altered compared with normal cells[3,4]. Two types of changes in the DNA methylation pattern can occur in cancer: global DNA hypomethylation and hypermethylation of CpG islands which are associated with gene silencing[3,4,7]. DNA in eukaryotic cells is intimately associated with a family of small, basic histone proteins forming a highly ordered and condensed DNA-protein complex termed chromatin. Because of this chromatin structure, changes in DNA methylation in cancer cells are not isolated events; they occur in the context of more complex epigenetic deregulation[9]. Chromatin is the physiological template of the genetic information and is composed of DNA, histones, and other chromosomal proteins. The fundamental repeating unit of chromatin is the nucleosome octamer, which consists of 147 base pairs of DNA wrapped around 2 copies each of histones H2A, H2B, H3 and H4[10]. The amino-terminal tails of histones are subject to posttranslational modifications, including acetylation, methylation, phosphorylation, ubiquitination, SUMOylation, and ADP-ribosylation[11], and multiple histone modifications may occur on a given histone tail[12]. Histone modifications patterns distinguish the structure of chromatin status, in particular, acetylation of histone H3 and H4 is associated with active gene expression with open chromatin structure. Histone acetylation is regulated by several enzymes such as histone acetyltransferase and histone deacetylases activity. Aberrations in post-translational modifications of histones have been shown to occur in cancer cells. Although alterations in global histone modification patterns in cancer cells have remained unknown, recent studies on global histone modifications at specific amino acids have been suggested as predictive clinical outcomes for various cancers[13-15]. Additionally, a number of studies have been focused only on changes of a particular histone modification at individual gene promoters in cancer cells.
In last 4 decades, researchers have developed various tools for exploring DNA methylation, and started to apply those new technologies to the field of nutrition science. The methyl-deficient model of endogenous hepatocarcinogenesis is one of which in DNA methylation has been extensively studied. This animal model is unique in that dietary omission rather than chemical carcinogens addition can lead to tumor formation[16]. Specifically, deficiency of the major dietary sources of methyl groups - methionine, choline, folic acid and vitamin B12 - leads to the development of liver cancers in rats and certain mouse strains[17-19]. From early 1990, these animal models have shown that the methyl-deficiency is associated with several defects, including genome-wide DNA hypomethylation and gene-specific hypermethylation[20-22]. Importantly, the aberrant epigenetic alterations imposed by this diet have been hypothesized to be the primary mechanism responsible for malignant transformation of rat liver cells[15,20,22,23]. Figure Figure11 displays a simplified version of biological methylation pathway from one-carbon metabolism, emphasizing that various dietary methyl sources (methionine, choline, various co-enzymatic forms of folate and vitamin B2, B6 and B12) play an important roles in DNA methylation. Methyl source deficiency has marked effects on the flow of one-carbon units through this web of reactions as the effect of methyl source deficiency are highlighted in red. The major effect observed in methyl deficiency models is a rapid decrease in hepatic S-adenosylmethionine (SAdoMet) levels and genomic DNA hypomethylation. In other recent studies examining the early stages of hepatocarcinogenesis induced by methyl deficiency in rats, substantial alterations in other aspects of the epigenetic machinery have been observed, including aberrant expression of DNA methyltransferases and methyl-CpG binding proteins[24], defects in histone methyltransferase protein expression and histone posttranslational modifications[15]. In Table Table1,1, various DNA methylation assays were summarized in methyl-deficient model of hepatocarcinogenesis in rodents.
One of widely used methods for global DNA methylation assay is a radioassay that utilizes the enzyme SssI DNA methyltransferase to catalyze the de novo methylation of the CpG sites with radiolabeled [3H]-SAdoMet, a universal methyl donor in vitro[20,25-28]. And another method was developed thanks to the discovery of methylation-sensitive restriction endonucleases. In 1999, Pogribny et al[29] developed a new method based on methylation-sensitive endonucleases followed by single nucleotide extension with radiolabeled [3H]-dCTP. This cytosine extension assay was used in various studies of methyl-deficient model of hepatocarcinogenesis for genomic DNA methylation[22,23,29,30]. These enzyme based methods have wide variations in precision as a result of inconsistency in the activity of methyl-sensitive endonucleases and the instability of methyltransferase activity[31]. In 2002, Friso et al[32] developed a method for quantitative determination of 5-methyl-2'deoxycytidine using liquid chromatography/electrospray ionization/mass spectrometry (LC/ESI/MS). This method allows accurate measurement of the absolute amount of 5-methyl-2'deoxycytidine relative to the total amount of cytosine residues, furthermore, it requires relatively lower amount of DNA and has a shorter run time for each sample than other high-performance liquid chromatography-based methods[33-35]. DNA methylation assay by LC/ESI/MS has been widely used for quantitative DNA methylation in animal studies and population-based studies in the light of its greater reproducibility and precision in large number of samples[32,36-40].
DNA methylation has long been recognized as an important factor on the silencing of genes, therefore it has become important to know the methylation status of individual CpG site. The first generation of DNA methylation detection assay is Southern blot or polymerase chain reaction (PCR) amplification that follows the enzyme digestion with methylation-sensitive restriction endonucleases[41-46]. Currently, the most commonly used methods for gene-specific DNA methylation can be categorized into three major methods.
Bisulfite DNA sequencing and methylation-specific PCR: Treatment of DNA with bisulfite converts cytosine residue to uracil, but leaves 5-methylcytosine residue unaffected. Bisulfite sequencing involves chemical conversion of cytosine to uracil, followed by PCR, and DNA sequencing[47]. While providing single-base resolution, the high cost and labor-intensive steps limit the use of this method for high-throughput analyses[48]. Methylation-specific-PCR also employs bisulfite conversion, but avoids the need to sequence the area of interest. Instead, methyl-specific and unmethyl-specific primer sets are designed, to distinguish methylated from unmethylated DNA in bisulfate-converted DNA[49]. This method is powerful to explore CpG islands with high methylation density, as increased numbers of CpG in the primer increase the specificity of the assay. However, these two methods using bisulfite conversion are not currently suitable for whole-genome analysis on multiple samples but commonly used for data validation from array-based methods.
Methods that focus specific single-CpG: These include Combined Bisulfite Restriction Analysis (COBRA)[50], MethyLight[51], and bisulfite pyrosequencing[52]. In COBRA, the combination of bisulfite conversion and PCR amplification is used, therefore it results in sequence conversion (unmethylated cytosine residue to thymidine and methylated cytosine to cytosine) which can lead to new methylation-dependent restriction enzyme sites. The following digestion of the PCR product with at least one CpG site in the recognition sequence only proceeds if the CpG site is protected from bisulfite conversion by methylation. For this reason, the signal ratio of restriction products indicating methylation to undigested PCR product representing unmethylated sequences can be used as a measure for the methylation level of this specific CpG. MethyLight is a bisulfite-dependent, fluorescence-based, quantitative real-time PCR method for DNA methylation. MethyLight relies on methylation-specific priming combined with methylation-specific fluorescent probing. This combination of methylation-specific detection principles results in a highly methylation-specific detection technology, with an accompanying ability to sensitively detect very low frequencies of hypermethylated alleles. Bisulfite pyrosequencing has been used to analyze bisulfite-converted DNA without using methylation-specific PCR. Following PCR amplification of the region of interest, pyrosequencing is used to determine the bisulfite-converted sequence of specific CpG sites in the region. The ratio of cytosine to thymidine at individual sites can be determined quantitatively based on the amount of cytosine and thymidine incorporation during the sequence extension. While the methods mentioned above are sensitive, specific, and relatively inexpensive, none of these methods is suitable for analysis of the whole genome, which includes about 28 million CpGs.
Microarray-based methods: These enable to interrogate larger numbers of CpG, there are three major types of microarray-based methylation analysis. Direct hybridization to CpG island arrays is the first high-throughput approach capable of detecting DNA methylaion in genes across several CpG sites. Based on the bisulfite modification of DNA, this method utilizes methylation-specific oligonucleotides arrayed on glass slides for detection of all possible methylation in target DNA[53]. Methylated DNA immunoprecipitation (MeDIP) is also a large-scale, genome-wide purification method that is used to enrich for methylated DNA sequence using antibody raised against 5-methylcytosine[54]. DNA from MeDIP can be used for either array-based hybridization (MeDIP-chip) or high-throughput sequencing (MeDIP-seq). Although MeDIP helps generate comprehensive DNA methylation profiles, both applications have their typical limitation of array-based technology, restricted resolution. The HELP assay (HpaII tiny fragment enrichment by ligation-mediated PCR) is comparative isoschizomer profiling of DNA methylation[55]. DNA is digested by HpaII in parallel with MspI (resistant to DNA methylation), and then the HpaII and MspI products are either amplified by ligation-mediated PCR and hybridized using separate fluorochromes to a customized array, or directly sequenced[56]. These high-throughput array-based approaches for DNA methylation are relatively inexpensive tool suitable for genome-wide analysis, therefore, help to target aberrant methylation patterns in various cancer models. Furthermore, methylation profiling achieved from high throughput methods will offer differentially methylated regions to understand the effect of dietary factors on epigenetic modifications in cancer, subsequently, provide insight in prevention strategies to reduce the burden of cancer.
In addition to the effects on DNA methylation, dietary components can affect posttranslational modifications of histones. The dietary agent best studied in histone modifications is the short chain fatty acid butyrate which is generated in the colon as a result of bacterial fermentation of dietary fiber. Higher intake of dietary fiber is associated with reduced risk of colorectal cancer[57,58]. The molecular mechanisms underlying this anti-cancer effect of dietary fiber are poorly understood, however, the strongest evidence is based on the anti-carcinogenic actions of butyrate. Butyrate can be found at millimolar concentrations in the lumen of the colon[59], and has inhibitory effects on types I and II histone deacetylase enzymes. Butyrate-induced alterations in histone marks, especially acetylation at histone H3 and/or H4, have been associated with several processes, including cellular differentiation[60,61], cell cycle arrest[62-64], apoptosis[65-67], and inhibition of invasion[68] in a number of cancer cell studies. Table Table22 summarized some of evidence of the effects of butyrate on histone acetylation. Although butyrate has strong marks on histone acetylation, a small fraction of cellular genes is regulated in response to butyrate[69-71]. Therefore, it should be noted that site-specific approach by chromatin immunoprecipitation (ChIP) based experimental tools will provide a better understanding on the chemopreventive effects of butyrate, showing gene-specific histone acetylation and its associated gene expression.
The first estimates for the rate of acetylation turnover were measured by pulse, pulse-chase, and steady-state acetylation labeling in hepatoma tissue culture cells in 1975[72]. Boffa et al[73] showed that sodium butyrate suppressed histone deacetylation in vivo and in vitro by measuring the kinetics of [3H] acetate release from histone proteins. Since specific antibodies to modified histones were developed, Western blot has been used to detect histone modifications. As shown in Table Table2,2, butyrate-induced histone acetylation was confirmed by Western blot in many studies.
ChIP: The antibodies to acetylated histone H3 and H4 have been used for ChIP to determine histone acetylation in specific regions of gene promoter and other regulatory regions. ChIP is a specialized immunoprecipitation used to detect the covalent interaction between the DNA sequence and DNA-binding proteins such as transcription factors or histone proteins. ChIP using histone antibodies is able to determine the specific location in the genome that various histone modifications are associated with, indicating the target of the histone modifiers[74]. For example, ChIP experiment unveiled that butyrate induced an increase in histone H3 and H4 acetylation within the CDKN1A promoter, which regulates the p21 protein, in Colo-320 human colon cancer cells[64]. Due to its ability to precisely detect the DNA binding of modified histones, transcription factors, and non-histone chromosomal proteins, ChIP has been widely used to generate and test numerous hypotheses regarding transcriptional and epigenetic regulations. However, it remains to be still challenging to conduct ChIP on an "epigenome" level, since ensuring an antibody of high specificity is often laborious and time-consuming. Another important concern with ChIP scalability is the maximum range of target regions that can be investigated by a single assay. For instance, a typical experiment of ChIP coupled with qPCR is designed to measure the enrichment levels of a DNA binding protein at a handful of sites (e.g., gene promoters). However, in general, even a single epigenetic event in the cell pervasively occurs over a wide range of genomic regions, often involving thousands of genes and their associated regulatory elements. Thus, it becomes more important to have an ability to run the assay on a genome-wide scale for having a more balanced and unbiased perspective on the underlying mechanisms. Coupled with genomic profiling technologies such as tiling arrays or next generation sequencing (NGS), ChIP can be extended over the whole genome. In the following sections, we will introduce two major methods coupled with ChIP that enable epigenome-scale research of histone marks and transcription factors.
ChIP-chip: ChIP-chip is based on the combination of ChIP and a genomic tiling array technology (i.e., chip), in which DNA sequences extracted after ChIP hybridize with probes that are designed to cover the whole genome or specific regions of interest such as promoter[75,76]. Due to bias in microarray hybridization, a control experiment using chromatin input or DNA from non-specific immunoprecipitation (IP) (e.g., IP against immunoglobulin G) is often recommended. Most algorithms for ChIP-chip are designed to compute the normalized ratio between the hybridizations of ChIP and control after removing random and/or systemic noise. Then, they call binding sites as those significantly enriched in ChIP over control[77-79]. Since its emergence in the early and mid 2000s, ChIP-chip has been widely adopted in many transcriptional and epigenetic regulation studies, assisting scientists to more understand the role of each histone mark in physiological and pathological processes[80-83]. However, the utility of ChIP-chip is heavily restricted by a tiling array probe design, which determines the resolution of the measurement (i.e., intervals between adjacent probes) and the regions that can be explored (e.g., omission of repetitive sequence areas). These weaknesses of ChIP-chip have accelerated the major platform shift to NGS.
ChIP-Seq: In ChIP-Seq, the extracted DNA sequences are directly sequenced using a NGS technology instead of being hybridized onto tiling arrays. NGS refers to sequencing technologies that newly emerged since the mid 2000s as an alternative to the traditional automated Sanger sequencing. NGS is characterized as massive parallel sequencing of template DNA or RNA (cDNA) molecules by a relatively short length ranging over 50-400 bp[84]. One advantage of ChIP-Seq over ChIP-chip is that ChIP-Seq does not require any predefined array design, which allows a more unbiased assay at a much higher resolution (100-1000 bp in ChIP-chip vs 10-100 bp in ChIP-Seq). Since NGS generally produces a notoriously large amount of data than array-based methods, more powerful bioinformatics support is essential for data processing and analysis[85,86]. Bioinformatics analysis for ChIP-Seq in epigenetic research includes the pre-processing for sequence data such as quality control and read mapping, the identification of candidate sites enriched by the target histone mark, and further down-stream analysis for revealing biological implications of the observations from the precedent steps[85,86].
In cancer studies, the down-stream analysis is focused on finding the most associated genes or regulatory elements (e.g., promoters or enhancers) with the histone mark of interest and investigating how these genes and regulatory elements can be understood in the context of biological pathways. Since Barski et al[87] and Wang et al[88] studies on 19 histone methylations and 18 histone acetylations using the human CD4+ T cell, many studies have been done to understand the biological implications of histone marks in normal conditions[80-82]. However, due to the plasticity of epigenome and heterogeneity of cancer, cancer epigenetics of examining histone modifications on a genome scale still remains in its beginning stage. For this reason, most of currently on-going efforts in cancer epigenetics still largely target DNA methylation (e.g., The Cancer Genome Atlas, http://cancergenome.nih.gov/)[89]. Therefore, it will be a long-term goal to accumulate the knowledge on cancer epigenetics from histone modifications and use it for cancer studies, which will require a great amount of public and private investments. Another interesting research direction is an attempt to comprehend how genetic variations lead to epigenetic changes in cancer. In 2011, several studies have been published about the possibility of multiple chromatin remodelers and histone enzymes as potential oncogenes or tumor suppressor genes[90-93]. These studies suggest that the disruption of chromatin remodelers and histone enzymes due to driving somatic mutations in their coding regions may cause aberrant epigenetic changes, which eventually lead to cancer development or evolution in at least several cancer indications. Such approach is particularly interesting because it may be able to provide a genuine perspective on the target histone mark by observing somatic mutations in several key chromatin remodelers and histone enzymes.
In conclusion, a number of aberrant epigenetic modifications have been found in cancer cells, and diet and dietary factors play an important role to prevent cancer as well as to stimulate carcinogenesis. The use of epigenetic technology offers significant advantages to study the epigenetic mechanisms of cancer development and progression. Also, the newly developed technologies for epigenetic study expand the scope of nutrition study in the field of cancer research by helping monitor and pin down specific epigenetic pathways in diet-related cancers.
P- Reviewer Prasad KK, Lakatos PL S- Editor Huang XZ L- Editor A E- Editor Xiong L
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STOUGHTON -- Police Lt. Bonney was on a random patrol Friday when he saw two men loading a stove into a vehicle in the driveway of a building he knew was unoccupied.
Stoughton Deputy Police Chief Robert Devine said Bonney asked where they had gotten the stove and was given an unlikely explanation. He determined that the men were breaking into the building and arrested them.
Drew Foley, 18, of 101 Birch St., and Shaun McDonald, of 83 Pearl St., both of Stoughton, were charged with breaking and entering in the daytime for a felony, larceny and conspiracy to commit a crime.
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