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When U.S. head soccer coach Jurgen Klinsmann accepted the job in 2011, he took over a program that won its group in the 2010 World Cup under Bob Bradley but still needed a new direction.
Sunil Gulati, U.S. Soccer Federation president, had courted Klinsmann in the past, but after falling to Mexico in the 2011 Gold Cup final a change was made. Gulati believed that Klinsmann was the man to elevate U.S. soccer to among the elite teams in the world.
"It's come a long way — soccer in the United States — and I'm now getting the opportunity to move it forward," Klinsmann said in his introductory press conference.
MORE: Scouting the World Cup groups
On TV: World Cup schedule
Since taking over leadership of the national team, Klinsmann has followed through on his promise. He coached the U.S. to its first-ever win at Mexico's Estadio Azteca, qualified for the World Cup that begins this week in Brazil, won a Gold Cup and led the team to a world-best 12-game winning streak in 2013.
As the U.S. was enjoying the best stretch in its history, its biggest rival, Mexico, struggled to even qualify for the World Cup. Since winning the Gold Cup in 2011, Mexico soccer spiraled downward in World Cup qualifying and fired three managers before settling on Miguel Herrera to lead the team in Brazil.
U.S. soccer's progress is often measured against its rival, and Klinsmann has yet to lose to Mexico.
The momentum on the field is clear. But so is the challenge that awaits.
After cruising through its qualification region en route to a World Cup berth, the optimism surrounding U.S. screeched to a halt on Dec. 6, 2013.
That day, in Bahia, Brazil, the U.S. learned that it would be placed in Group G along with second-ranked Germany, fourth-ranked Portugal and Ghana — a team that eliminated the U.S. in the past two World Cups.
Moreover, the U.S. will need to travel 8,874 miles to play its three group-stage matches and take on Cristiano Ronaldo — arguably the best player in the world — and Portugal in the hostile Amazonian climate of Manaus.
"We discussed it before the draw that there would be some problems on the traveling side, and we hit the worst of the worst," Klinsmann told the media following the draw.
With the worst-case scenario of a "Group of Death" realized, Klinsmann returned to the drawing board. U.S. soccer extended his contract through the 2018 World Cup, alleviating the pressure to win in Brazil.
U.S. soccer fans:
But to move U.S. soccer forward, the team would eventually have to test itself against the world's best. And this summer's World Cup in Brazil will be that chance.
Brazil is the definitive favorite to lift the World Cup trophy in Rio de Janeiro's Estadio Maracana next month. Led by the creative 22-year-old Neymar, Brazil blitzed defending World Cup champion Spain 3-0 in last summer's Confederations Cup final. Is the U.S. ready to compete at the level of Brazil, Argentina and Spain? Few are, but this tournament will serve as a measuring stick.
"We've had a very, very good two years, the best two years in our history," Gulati said after the draw. "It's a tough group, but they are all tough groups at some level. If you want to advance in the World Cup, you have to beat some good teams."
In order to advance out of the group, Klinsmann needs his squad to be at top form for every match, and every player on the roster must play a significant role. When the roster was released on May 22, one glaring omission sent shockwaves around soccer.
With the decision to leave Landon Donovan, the most decorated player in U.S. soccer history, off the 23-man roster, Klinsmann effectively turned the page on U.S. soccer's past and looked forward. The move was met with shock, anger and confusion from players and fans alike.
"I think obviously it was a massive surprise," said U.S. national team hopeful and Phoenix native Brad Evans, who also didn't make the final team. "Amongst the players, amongst players from other countries in the locker room, we kind of don't understand the decision."
The roster features a youthful, inexperienced group along with U.S. soccer mainstays Michael Bradley, Clint Dempsey, Jozy Altidore and Tim Howard. With Julian Green, 19, and DeAndre Yedlin, 20, earning trips to Brazil, it raised speculation that Klinsmann is focused on building for the future rather than this summer.
"No, this (team) is based on today," Klinsmann told the media after releasing the roster. "This is based on what hopefully goes well the next seven or eight weeks. It has nothing to do with my contract or with the perspective that those players have for the longer run."
Whether the U.S. makes a deep run in Brazil or not, Klinsmann will continue to work to take the U.S. to that next step.
Welcome to the new era of U.S. soccer.


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Theoretical and analytical aspects of the visual servoing problem have not received much attention. Furthermore, the problem of estimation from the vision measurements has been considered separately from the design of the control strategies. Instead of addressing the pose estimation and control problems separately, we attempt to characterize the types of control tasks which can be achieved using only quantities directly measurable in the image, bypassing the pose estimation phase. We consider the task of navigation for a nonholonomic ground mobile base tracking an arbitrarily shaped continuous ground curve. This tracking problem is formulated as one of controlling the shape of the curve in the image plane. We study the controllability of the system characterizing the dynamics of the image curve, and show that the shape of the image curve is controllable only up to its "linear" curvature parameters. We present stabilizing control laws for tracking piecewise analytic curves, and propose to track arbitrary curves by approximating them by piecewise "linear" curvature curves. Simulation results are given for these control schemes. Observability of the curve dynamics by using direct measurements from vision sensors as the outputs is studied and an extended Kalman filter is proposed to dynamically estimate the image quantities needed for feedback control from the actual noisy images

subset: commoncrawl


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Sesame Street Season 46
Sesame Street's 46th season officially began Saturday January 16 on HBO. After you see the new episodes, post here and let us know your thoughts.
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our mailing list. It's so wizard.
Trash Talk
10 September, 2014 4:27 pm
"Modern Mayhem" is the fourth single off of the second Converse CONS compilation, CONS EP Vol. 2, with one final single coming later this fall. The song was produced by Trash Talk's Garrett Stevenson and recorded at Converse Rubber Tracks in Brooklyn, New York.
1 May, 2014 8:34 am
The video for "97.92," the result of collaboration between Aplusfilmz and Pier Pictures, was created using a 360-degree HD camera rig with a remote-controlled drone octo-copter. The device is the H3Pro7, invented by Michael Kintner, which shoots with 7 GoPro cameras all rolling simultaneously. The 7 shots are synced and stitched together to create the [cont.]
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I want to create a live stream from a satellite receiver. The output available is RCA audio/video. How can I use it and connect to PC so that I can stream? Any specific hardware for Linux?
migrated from stackoverflow.com Jul 6 '12 at 8:35
This question came from our site for professional and enthusiast programmers.
if your videocar has an video-in connection you may use that, else try to buy an converter/adapter.
What you can do also, if you have the money, buy an sattelite reciever which has usb support or dvi/vga/hdmi, these can be linked to the pc if you have the correct hardware.
I think an usb sattelite reciever would be your best bet.
EDIT: Added this comment:
I noticed it's RCA, I think this would be your all-in-one solution:
There are (I think) no linux drivers but you could use a windows emulator or some wrapper for the DLL's.
(Windows Emulator would be you easiest option as the software will run on it too)


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The Polytech Choir
The Polytech Choir (Finnish: Polyteknikkojen Kuoro; PK) is an academic male choir, established in 1900, that performs regularly in Finland and abroad. The majority of the choir's members are engineering students and graduate engineers from Aalto University. The activities of the choir include traditional spring and Christmas concerts, frequent recordings, and performances with leading Finnish symphony orchestras. The choir's current artistic director and conductor, since 2013, is Saara Aittakumpu.
PK's a cappella repertoire consists mainly of classical music, ranging from the Romantic era to contemporary works, and also includes occasional forays to other genres such as jazz. A centerpiece of the choir's choral symphonic repertoire has been Jean Sibelius' symphonic poem Kullervo. In addition to performances a cappella and with orchestras, the choir, its quartets and other smaller ensembles frequently perform at private, corporate and academic festivities.
The Polytech Choir has commissioned and premiered nearly 40 new works for male choir during the past 20 years, including two International Rostrum of Composers prizewinners by Jukka Tiensuu and Eero Hämeenniemi, and Finnish premieres of works by Luciano Berio and Toru Takemitsu. The choir's most recent first performances have included works from the Finnish composers Riikka Talvitie, Olli Kortekangas, Mikko Sidoroff, Markku Klami, Tiina Myllärinen, Jouni Kaipainen, Maija Hynninen, Lotta Wennäkoski, and a work by the jazz pianist and composer Iiro Rantala.
- Heikki Klemetti (1900–ca. 1905)
- Martti Pitkänen (1910s)
- R.R. Ryynänen (1920s)
- Ossi Elokas (1933–1969)
- Eero Erkkilä (1969–1971)
- Heikki Saari (1971–1984)
- Tapani Länsiö (1984–2004)
- Juha Kuivanen (2004–2013)
- Saara Aittakumpu (2013–)
Selected discography[edit]
- Toki! (contemporary Finnish works for male voice choir composed in the 1980s) (1990)
- Matkalla – Male Voice Voyage (contemporary Finnish works for male voice choir composed in the 1990s) (1999)
- Me toivotamm' (choral works for Christmas, sol. Essi Wuorela) (2000)
- Vuodet – Polyteknikkojen kuoro 100 vuotta (works performed by the choir during its first century) (2004)
- Mies (National Romantic, 20th century and contemporary works for male voice choir) (2006)
- Kultakausi (Finnish National Romantic works for male voice choir) (2008)
- Joulu on meillä (choral works for Christmas, sol. Matti Salminen) (2009)
- Kuunteletko Sinä (contemporary Finnish works commissioned by the choir between 2007–12) (2013)
See also[edit]
External links[edit]
|This article about a Finnish band or other musical ensemble is a stub. You can help Wikipedia by expanding it.


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March 24, 2014
West Michigan's Best & Brightest
Hastings City Bank is pleased to announce that we have received the honor of being named one of West Michigan's Best & Brightest Companies to Work For! This is the sixth consecutive yearRead on »
March 19, 2014
HCB Earns Highest 5-Star Superior Safety Rating!
5-Star Hastings City Bank:
Committed to its Customers and Community
March 13, 2014
Did You Know?
Hastings City Bank will never call a customer and ask for personal information, nor will we send an email asking for your personal information. Please stop and think, and protect yourselfRead on »
March 10, 2014
Free Credit Report Information
How to obtain your free annual credit report as provided under the FACT Act.
March 3, 2014
Did You Know?
Our http://www.hastingscitybank.com website is a great resource for electronic banking security information. Click the Security Information link at the top of our home page for general bestRead on »
December 16, 2013
HCB Earns Highest 5-Star Superior Safety Rating!
5-Star Hastings City Bank:
A Dependable and Financially Sound Community Bank
« Previous Page ‹ First < 8 9 10 11 12 > Last › Next Page »


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11 of the Most Splendid Mullets You'll Ever See
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Elizabeth Rage takes you through the steps to create the Enchantress look f...
On this episode, Master Chalk Artist Chris Carlson takes on an epic Star Tr...
Get you geek on and come check out these hilarious clips!
Posted by Fortey on Apr. 13, 2012


text: 7. Trustco Bank Corp. Shares of Trustco Bank Corp. ( TRST) of Glenville, N.Y., closed at $3.63 Friday, returning down 6% year-to-date, following a 7% decline in 2011. Based on a quarterly payout of 6.5625 cents, the shares have a dividend yield of 5.05%. The company had $4.2 billion in total asset as of Dec. 30, and its quarterly ROA ranged from 0.77% to 0.88% during 2011, according to HighlineFI. The shares trade for 1.4 times tangible book value and 12 the consensus 2012 EPS estimate of 43 cents. The consensus 2013 EPS estimate is 49 cents. Trustco earned $8.7 million during the fourth quarter, or 9.3 cents a share, declining from $9.2 million, or 10 cents a share, in the third quarter, but increasing from $6.9 million, or nine cents a share, in the fourth quarter of 2010. The sequential earnings decline reflected a $551,000 increase in expenses for salaries and employee benefits, and "a $450 thousand one-time item that increased the effective tax rate and is not expected to be repeated in 2012." Trustco's net interest margin -- the difference between a bank's average yield on loans and investments and its average cost for deposits and wholesale borrowings -- narrowed to 3.35% from 3.38% the previous quarter and 3.43% a year earlier, however, net interest income increased 6% year-over-year to $34.0 million in the fourth quarter, reflecting not only lower interest expenses, but a 6% increase in average loans during the fourth quarter. Interested in more on Trustco Bank Corp.? See TheStreet Ratings' report card for this stock. Prev 4 of 11 Next


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Sorry ... I don't want to assume something wrong ... but I think you still don't give us all the information we need
Most importantly: Where do you have (or where do you WANT to have) the call to topic.php? Where do the parameters come from?
As far as I understand: You want to click a link, start a request to topic.php with the two parameters id and quote.
Where do id and quote come from? What do you want to do with the output of topic.php? Do you want to write the output to the element #replyText or is this element part of topic.php and you only want to read the content of #replyText from topic.php?
You leave me confused.


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Dr. Chadwick graduated from the University of Minnesota Medical School at Minneapolis in 1994. He works in Golden Valley, MN and 1 other location and specializes in Child Neurology and Neurology. Dr. Chadwick is affiliated with Childrens Hospitals & Clinics Of Minnesota, Fairview Ridges Hospital, Fairview Southdale Hospital, Mercy Hospital and North Memorial Medical Center.
Child Neurology, Neurology
Medical School: University of Minnesota Medical School at Minneapolis; Graduated 1994
Please verify insurance information directly with your doctor's office as it may change frequently.
*This physician has multiple office locations. See Office Information for details.
716 S 7th St
Minneapolis, MN 55415
2855 Campus Dr Ste 570
Minneapolis, MN 55441
2828 Chicago Ave Ste 200
Minneapolis, MN 55407
2828 Chicago Ave Ste 200
Minneapolis, MN 55407
225 Smith Ave N Ste 201
Saint Paul, MN 55102


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Contact details
Are these details correct?
Hotfrog UK provides information regarding Boddy & Ridewood in Scarborough North Yorkshire. Boddy & Ridewood is located at Faroe House Thornburgh Road Eastfield, Scarborough North Yorkshire YO11 3UY and provides Catalogue Shopping services. Contact them on 01723585858.
Is Boddy & Ridewood in Faroe House Thornburgh Road Eastfield, Scarborough North Yorkshire YO11 3UY your business? Claim your listing and attract more leads by adding more content, photos and other business details.
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I can't believe they approved me![ Edited ]
10-08-2012 12:53 PM - edited 10-08-2012 12:56 PM
I'll apologize in advance... this is a bit of a brag post .
My wife and I had our first child just a little over a week ago. We had been talking about buying a small SUV/Crossover type vehicle as we both currently drive Honda Civic 2 door coupes. After a week of trying to lug a carseat in and out, plus fit the stroller and all the baby stuff, I was pretty fed up.
I called my CU and applied for an auto loan. They called me back and said that they could not approve me because of "excessive obligations" and "recent delinquency." I explained the baddies on my report and they said to call back when those were cleared up and they would reevaluate.
As for the baddies/credit history - I joined these forums about a year ago. My credit score was a 560. I had a handful of collections, medical collection, excessive lates on my SL's, defaulted on a few other student loans. I did lots of work, got quite a few deletes, did a few PFD, and worked on rehabing my SL's (which I learned about on these forums! THANK YOU!). I even opened up to secured CC's and was approved for an unsecured $500 limit. Things started to go up, then they dropped down to 530 and I've been building back up since.
I spoke to a family member about the denial and she offered to cosign. We were scheduled to go out the following weekend to "seal the deal." I decided to go out and look at some cars this past weekend and fell in love with the CR-V. I found a 2012 Honda CR-V EX and it had the space we needed plus a few extra perks that I wanted. Since I had already had my CU pull my credit, I knew it wouldn't hurt me to have Honda pull it and see what they could do for me. I told Honda the payment amount I was looking for and that I didn't want an outrageous APR as I could just come back the next weekend with a highly qualified cosigner and get something better.
They ran the numbers, came back, told me the payments, terms, APR, etc., and to my surprise they somehow qualified me for 4.49% with American Honda Finance. My Equifax score is a 578 and my Auto Enhanced score is a 601. I'm completely baffled. I was able to get the car I wanted ( I would have been happy with the lower LX model, but they lowered the price to make it work), a car payment $5 below my max (hahha.. not much, but it's something), and the APR of someone with far better credit.
(not my actual car)
Edit: Double posted image.
Starting Score: EX: 560 on 11/1/11
Current Score: EX: 651 on 1/31/16
Goal Score: 700
Take the FICO Fitness Challenge


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Pecos is a P.R.E./Andalusian stallion registered with both ANCCE and IALHA. Pecos was the 2008 3rd and 4th level dressage IALHA National Champion and qualified for USDF championships at PSG and Intermediare 1 in 2010. Pecos also travels North America to perform his La Garrocha Act and a classical dressage act at exhibition venues. Pecos was selected to be the Celebration horse at the 2011 Breyerfest. A true ambassador for the breed, Pecos passes on his beauty and his fabulous temperament to his offspring.... (read more)
Dressage training and instruction from training level to Grand Prix. Sales horses available. Andalusian stallions at stud.
Avoid Scams and Fraud - Potential areas of fraud: wire transfer, moneygrams, money orders, cashier checks, shipping, escrow, "transaction protection", "guarantee". Check out the Buyer Safety section for more info.


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Top 25 Chuck Norris-isms
Who is the baddest man on the planet?
If you say Mike Tyson, I will roundhouse kick you back into reality.
If you say anybody other than Chuck Norris, I will beat you into submission.
I'm not talking "Walker Texas Ranger" or "Top Dog" Chuck Norris, I'm talking about "Delta Force," "Missing in Action," "An Eye for an Eye," "Lone Wolf McQuade," "The Octagon" and a "A Force of One" 1980s Chuck Norris.
In all those movies you wanted to be Chuck Norris, but you didn't want to be Chuck's wife/girlfriend or best friend/army buddy/relative because you either got raped, murdered or tortured or a combination of all three.
But, of course, Chuck Norris always came back and avenged any wrong doing. Still, being Chuck Norris' wife, girlfriend, best friend, army buddy or relative was not the place to be during his prime in the 1980s.
Anyway, I was listening to an old interview Chuck Norris did with the King of All Media Howard Stern in September of 1999 on Howard Stern's Mastertape Theater this past weekend and it got me to thinking about Chuck Norris-isms.
With the help of History Addict, the Keep Punching blog salutes the baddest dude on the planet. I present to you my top-25 Chuck Norris-isms:
25. Chuck Norris spends hours staring directly into the sun. We call that "night."
24. Chuck Norris wears bear traps on his feet instead of sandals.
23. Chuck Norris once took sleeping pills. They made him blink.
22.� Chuck Norris' tears cured cancer. Too bad he never cried.
21. Chuck Norris doesn't read books. He stares them down until he gets the information he wants.
You are going to want to keep going. I promise, it gets better.
20. When Chuck Norris falls into water, Chuck Norris doesn't get wet. Water gets Chuck Norris.
19. Once, Chuck Norris went to the Super Bowl. He beat the Steelers, 45-3.
18. Chuck Norris once tried to sue Burger King after they refused to put razor wire in his Whopper Jr., insisting that actually is "his" way.
17. Chuck Norris never wears a motorcycle helmet. The concrete always scoots out of the way.
16. Chuck Norris came to my BBQ last summer, ate all the red-hot charcoal out of the grill and then proceeded to fart out large diamonds for the ladies in the awestruck crowd.
15. Chuck Norris played a game of Russian roulette with a fully-loaded gun and won.
14. The eternal conundrum "what happens when an unstoppable force meets an immovable object" was finally solved when Chuck Norris punched himself in the face.
13. When an episode of "Walker Texas Ranger" was aired in France, the French surrendered to Chuck Norris just to be on the safe side.
12. When Chuck Norris' remote control batteries die, the remote continues to function out of pure terror.
11. For every answer on the SAT test, write in "Chuck Norris." You will automatically score a 1,600.
10. The Titanic sank when it struck Chuck Norris doing laps in the North Atlantic. Chuck Norris would have stopped to save the survivors, but he didn't notice the impact.
9. Chuck Norris has the greatest poker face of all-time. He won the 1983 World Series of Poker despite holding only a Joker, a Get out of jail free Monopoly card, a 2 of clubs, 7 of spades and a green No.4 Uno card.
8. When Chuck Norris sends in his taxes, he sends blank forms and includes only a picture of himself, crouched and ready to attack. Chuck Norris has not had to pay taxes ever.
7. Chuck Norris loves Police Academy 2. This is the only reason Steve Guttenberg is still alive.
6. Upon the explosion of the Exxon-Valdez oil tanker in 1989, President Bush asked Chuck Norris to assist in the cleanup. Chuck Norris drank the oil, then he took an Eskimo as his bride. This is where Yeti come from.
5. Rather than being birthed like a normal child, Chuck Norris instead decided to punch his his way out of his mother's womb. Shortly thereafter he grew a beard.
4. Chuck Norris built a time machine and went back in time to stop the J.F.K. assassination. As Oswald shot, Chuck met all three bullets with his beard, deflecting them. J.F.K.'s head exploded out of sheer amazement.
3. Chuck Norris sold his soul to the Devil for his rugged good looks and unparalleled martial arts ability. Shortly after the transaction was finalized, Chuck roundhouse kicked the Devil in the face and took his soul back. The Devil, who appreciates irony, couldn't stay mad and admitted he should have seen it coming. They now play poker every second Wednesday of the month.
2. Chuck Norris recently had the idea to sell his urine as a canned beverage. We know this beverage as Red Bull.
1. There is no Santa Claus. On Christmas Eve, Chuck Norris circumnavigates the globe in his pickup truck dispensing gifts to good children and roundhouse kicks to bad ones. The children, upon receiving these kicks, die.
Note: In the following film clip you will see another side of "Hollywood" changing reality. Before each fight scene Chuck Norris films (in this case "Way of the Dragon" with Bruce Lee), he is injected with five times the lethal dose of elephant tranquilizer. This is, of course, to limit his strength and mobility, in an attempt to lower the fatality of the actors he fights.
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Dance song for Ngoma dance for men with foot stamping and women clapping. Translated English title - "My father has stopped using his fighting spear." Further details refer ILAM field card (C4X1).
Ngoni men and women (Performer)
78 RPM Acetate record
Sound Forge v. 8
Technics SP-10 MK II Direct Drive Turntable
Studer Revox Interface SP 10-B
Recording number 4465
International Library of African Music
International Library of African Music


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updated 08/28/2009 AT 7:00 AM ET
•originally published 08/28/2009 AT 9:00 AM ET
Prepare to be scared.
In New Moon, the second installment in Stephenie Meyer's wildly popular Twilight saga, readers are first introduced to the ancient ruling class of vampires known as the Volturi. Determined to capture their creepy menace for his screen version opening Nov. 20, New Moon director Chris Weitz has given them custom-crafted blood-red eyes.
"They're all hand-painted, specially manufactured contacts," Weitz tells PEOPLE. "They're opaque red, almost like preying mantis eyes. You can't really see into them. There's something terribly off-putting about it."
British actor Michael Sheen (The Queen) plays Aro, leader of the Italian blood-sucking clan. Although Aro and his brothers Marcus (Christopher Heyerdahl) and Caius (Jamie Campbell Bower) have been "alive" for thousands of years, Weitz says he "deliberately" gave them a younger look in the film – for which he credits author Meyer.
Perhaps most lethal of all the Volturi is Jane (Dakota Fanning), an angelic-looking vampire who inflicts torture on her victims. "She is very strange and very spooky in this movie," says Weitz. "I think [Dakota] wanted to play an evil character for once."


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It looks like we don't have any photos for Lance Greene yet. You can add or change photos at IMDb Pro. You can also browse other available content for Lance Greene on IMDb such as filmography, trivia, personal details, etc.
Lance Greene was born in Boston, Massachusetts and is the youngest of 10 children. Lance Greene spent a good deal of his career acting in New York city for just over 14 years. He worked on many Off Broadway productions including the critically acclaimed "God Willing" written by David McLaughlin. Lance had a supporting role and produced the award ... See full bio »


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Published on
Jawaharlal Nehru Port,
also known as Nhava Sheva, is the largest container port in India. Located south of Mumbai in Maharashtra, the port on the Arabian Sea is accessed via Thane Creek. Its common name derives from the names of Nhava and Sheva villages that were situated here. This port is also the terminal of Western Dedicated Freight Corridor proposed by Indian Railways.


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"La Isla Bonita" San Pedro by wreckloose
San Pedro Travel Guide: 74 reviews and 190 photos
Our plane tickets were bought and hotel reservations made months in advance... more than enough time to build up the anticipation... so it was a curiousity as to why this trip lacked any of the usual fanfare. The more I thought about it, the more I couldn't shake the feeling that I was pretty unexcited about my vacation when it dawned on me... I knew absolutely nothing about the country of Belize.
One of the reasons I joined VT years back was to find out more information about the Philippines when I realized I was going back for the first time in almost 20 years... so naturally, VT was the first place I came back to for information on Belize.
On the day of our departure, I presumed I was armed with more than enough VT, Fodor and Lonely Planet tips to get me through our vacation. Despite that, I still found myself unprepared for how long it would actually take to get to our destination. We left Vancouver on a Saturday morning by Greyhound en route to our flight from Seattle-Tacoma Airport. After a pit stop at Taco Del Mar we were off to Houston and in the morning Belize City. One cab ride, a water taxi and 25 travel hours later we were finally docked in San Pedro.
Reviews (9)
Having a golf cart at our disposal was probably the best thing we could have done on our trip. Not to say walking was... more travel advice
My girlfriend's sister used to live in San Pedro, and during that time became friend's with the owner of a... more travel advice
Owned by celebrated local chef Amy Knox, Wild Mango's was definitely personal dining favorite on the island. The menu is... more travel advice
Located right in the middle of San Pedro, it's pretty much impossible to miss this 600 person capacity club. A huge... more travel advice
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I know this is kind of a funny request, but I'd like to disable page caching on our development database. I believe it would make it much easier to see the impact of various tweaks that are done, and I'm most curious about time to retrieve uncached pages, not so much how efficiently MSSQL can pull data from cache.
However, this must be done on the database level, so I can't just set the server's memory cache to an absurdly low level (and this has a chance of knocking out index caches which I'd rather not do, and our development system has other databases I'd rather not touch).
The commands to flush the database AFAIK will flush it across all databases, and I'd rather not do that to our development database.
Not really a mandatory thing, but benchmarking is fairly difficult to get right when I can put my entire development database in page cache.


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When Bauer, the worlds most recognized name in hockey wanted to introduce an entirely new segment to their hockey family, they passed to team Baker. With the Supreme and Vapor lines firmly established, they Introduced the Nexus line to meet the needs of every individual hockey player.
Over the past year a group from BAKER has had the privilege of working with the Sandy Hook Promise organization to help them develop and extend an identity that harnesses the raw emotional energy this dedicated group puts toward sensible changes.
Dig into the creative process of how 5 Gum came to be one of America's hottest brands. A June, 2013 Harvard Business Review article on Creativity used 5 Gum as an example of one design dimension that significantly correlates with high sales.
The Star Tribune recently published an article in their business section featuring phrases like "most significant new products in years" and "one of the biggest product launches in our history"… turns out they were talking about our client Hormel and the REV snacks we helped launch.


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Why You Should Eat Your Frogs Early
September 13, 2010By Daphne Gray-Grant
I was born organized. In fact, I'm the kind of nut-bar who writes a family meal plan once a week. As a child, I longed to sort our family's books by size and color (no one would let me!). Now that I'm the mom, my spice drawer is alphabetized. Continue reading...


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A ten week basketball program open to all area 1st through 5th grade boys and girls is being offered by James Eyen and family, along with many other volunteers, at the Cambridge Parks Armory Gymnasium. The program will stress basketball skills, physical development, teamwork, friendly competition and fun! Each player will receive a basketball, t-shirt, jump rope, certificate and the chance to meet and work with high school players. The final week will be a recognition celebration and pizza party. The first five-week session of the program will be held on Saturdays beginning November 23rd. The second five-week session will be on Sundays beginning January 5th. Sign ups will be held at the Armory from 11:00 a.m. to 12:30 p.m. on the following Saturdays: November 9th, or November 16th. The program fee is only $25.00. Any questions, call Steve Eyen at 432-7773.
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I have used the slideshow on another site with the same settings with no problems. But with the wordpress theme 'TRINITY' on a new site the slideshow gets stuck on the 2nd slide. If I click the nav button, the slideshow continues, and loops through no problem.
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Manufacturing quality, Bright and matte display
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Traceability - the ability of developers to describe and follow the life of an artifact throughout the software development life cycle - is an important process that facilitates acquisition and use of process knowledge. While there has been extensive research focusing on the development of traceability solutions, there is a paucity of research that characterizes the tasks that need to be performed in implementing and using traceability. This research addresses this gap by conceptualizing traceability practice in software development as comprising information processing and communication among developers involved in the process. Accordingly, we present the results of two complementary studies focusing on these two aspects of traceability. Based on Study 1, we develop a process model for information processing in traceability. Through Study 2, we identify important contingency factors that impact the mode of communication among developers and customers. We argue that choice of communication media should be dictated by matching particular media characteristics such as synchronicity, reprocessability, and channel capacity to the situation at hand rather than by using aggregated measures such as media richness or social presence. We integrate the findings from our two studies into a process model that prescribes guidelines for traceability practice in software development. Our prescriptions also help traceability tool developers in delivering traceability support that facilitates appropriate information processing and communication capabilities, taking various project characteristics into consideration.
A not-for-profit organization, IEEE is the world's largest technical professional organization dedicated to advancing technology for the benefit of humanity.© Copyright 2016 IEEE - All rights reserved. Use of this web site signifies your agreement to the terms and conditions.


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Maritime Today
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A ceremony will be held July 29 at Cenac Marine Services headquarters in, Houma, La. To commemorate the christening of its newest vessel, M/V Quincey Cenac, as
Facing a "gradually deteriorating market," Sweden based tanker shipping company Concordia Maritime said it was able to post a profit in Q2 2016 based on high vessel
Nick Brown has been appointed Bureau Veritas' new Communications Director, Marine & Offshore Division, the classification society announced.
Brown will take up the post from November 2,
Norwegian oil firm Det norske said it expected to reach full production at its Alvheim FPSO (floating storage, offloading and producing unit) overnight after a leak,
1861 - During the Civil War, the frigate, USS St. Lawrence, spots a schooner flying English colors and gave chase. Some four hours later, as she is overhauling the schooner,
Standing NATO Mine Countermeasures Group 2 (SNMCMG2) has completed its third deployment into the Black Sea under the command of Captain Ramazan Kesgin, Turkish Navy.


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Invega Sustenna
Antipsychotics in Pregnancy Risky for Newborns »
"Feb. 22, 2011 -- The FDA has issued a safety announcement notifying health care professionals that it has updated the pregnancy section of drug labels for the entire class of antipsychotic medications.
Antipsychotic drugs are used to "...
Read the Antipsychotics in Pregnancy Risky for Newborns article »
Invega Sustenna
Mechanism Of Action
Paliperidone palmitate is hydrolyzed to paliperidone [see Pharmacokinetics]. Paliperidone is the major active metabolite of risperidone. The mechanism of action of paliperidone is unknown. However, it has been proposed that the drug's therapeutic activity in schizophrenia is mediated through a combination of central dopamine Type 2 (D2) and serotonin Type 2 (5HT2A) receptor antagonism.
Paliperidone is a centrally active dopamine Type 2 (D2) receptor antagonist and a serotonin Type 2 (5HT2A) receptor antagonist. Paliperidone is also active as an antagonist at α1 and α2 adrenergic receptors and H1 histaminergic receptors, which may explain some of the other effects of the drug. Paliperidone has no affinity for cholinergic muscarinic or β1- and β2-adrenergic receptors. The pharmacological activity of the (+)- and (-)- paliperidone enantiomers is qualitatively and quantitatively similar in vitro.
Absorption And Distribution
Due to its extremely low water solubility, paliperidone palmitate dissolves slowly after intramuscular injection before being hydrolyzed to paliperidone and absorbed into the systemic circulation. Following a single intramuscular dose, the plasma concentrations of paliperidone gradually rise to reach maximum plasma concentrations at a median Tmax of 13 days. The release of the drug starts as early as day 1 and lasts for as long as 126 days.
Following intramuscular injection of single doses (39 mg - 234 mg) in the deltoid muscle, on average, a 28% higher Cmax was observed compared with injection in the gluteal muscle. The two initial deltoid intramuscular injections of 234 mg on day 1 and 156 mg on day 8 help attain therapeutic concentrations rapidly. The release profile and dosing regimen of INVEGA SUSTENNA® results in sustained therapeutic concentrations. The AUC of paliperidone following INVEGA SUSTENNA® administration was dose-proportional over a 39 mg-234 mg dose range, and less than dose-proportional for Cmax for doses exceeding 78 mg. The mean steady-state peak:trough ratio for an INVEGA SUSTENNA® dose of 156 mg was 1.8 following gluteal administration and 2.2 following deltoid administration.
Following administration of paliperidone palmitate the (+) and (-) enantiomers of paliperidone interconvert, reaching an AUC (+) to (-) ratio of approximately 1.6–1.8.
Based on a population analysis, the apparent volume of distribution of paliperidone is 391 L. The plasma protein binding of racemic paliperidone is 74%.
Metabolism And Elimination
In a study with oral immediate-release 14C-paliperidone, one week following administration of a single oral dose of 1 mg immediate-release 14C-paliperidone, 59% of the dose was excreted unchanged into urine, indicating that paliperidone is not extensively metabolized in the liver. Approximately 80% of the administered radioactivity was recovered in urine and 11% in the feces. Four metabolic pathways have been identified in vivo, none of which accounted for more than 10% of the dose: dealkylation, hydroxylation, dehydrogenation, and benzisoxazole scission. Although in vitro studies suggested a role for CYP2D6 and CYP3A4 in the metabolism of paliperidone, there is no evidence in vivo that these isozymes play a significant role in the metabolism of paliperidone. Population pharmacokinetics analyses indicated no discernible difference on the apparent clearance of paliperidone after administration of oral paliperidone between extensive metabolizers and poor metabolizers of CYP2D6 substrates.
The median apparent half-life of paliperidone following INVEGA SUSTENNA® single-dose administration over the dose range of 39 mg - 234 mg ranged from 25 days - 49 days.
Long-Acting Paliperidone Palmitate Injection Versus Oral Extended-Release Paliperidone
INVEGA SUSTENNA® is designed to deliver paliperidone over a monthly period while extended-release oral paliperidone is administered on a daily basis. The initiation regimen for INVEGA SUSTENNA® (234 mg/156 mg in the deltoid muscle on Day 1/Day 8) was designed to rapidly attain steady-state paliperidone concentrations when initiating therapy without the use of oral supplementation.
In general, overall initiation plasma levels with INVEGA SUSTENNA® were within the exposure range observed with 6-12 mg extended-release oral paliperidone. The use of the INVEGA SUSTENNA® initiation regimen allowed patients to stay in this exposure window of 6-12 mg extended-release oral paliperidone even on trough pre-dose days (Day 8 and Day 36). The intersubject variability for paliperidone pharmacokinetics following delivery from INVEGA SUSTENNA® was lower relative to the variability determined from extended-release oral paliperidone tablets. Because of the difference in median pharmacokinetic profiles between the two products, caution should be exercised when making a direct comparison of their pharmacokinetic properties.
Drug Interaction Studies
Potential for INVEGA SUSTENNA® to Affect Other Drugs
In vitro studies in human liver microsomes demonstrated that paliperidone does not substantially inhibit the metabolism of drugs metabolized by cytochrome P450 isozymes, including CYP1A2, CYP2A6, CYP2C8/9/10, CYP2D6, CYP2E1, CYP3A4, and CYP3A5. Therefore, paliperidone is not expected to inhibit clearance of drugs that are metabolized by these metabolic pathways in a clinically relevant manner. Paliperidone is also not expected to have enzyme inducing properties.
Paliperidone is a weak inhibitor of P-glycoprotein (P-gp) at high concentrations. No in vivo data are available, and the clinical relevance is unknown.
In a drug interaction study, co-administration of oral paliperidone extended-release tablets (12 mg once daily for 5 days) with divalproex sodium extended-release tablets (500 mg to 2000 mg once daily) did not affect the steady-state pharmacokinetics (AUC24h and Cmax,ss) of valproate in 13 patients stabilized on valproate. In a clinical study, subjects on stable doses of valproate had comparable valproate average plasma concentrations when oral paliperidone extended-release tablets 3-15 mg/day was added to their existing valproate treatment [see DRUG INTERACTIONS].
Potential for Other Drugs to Affect INVEGA SUSTENNA®
While in vitro studies indicate that CYP2D6 and CYP3A4 may be minimally involved in paliperidone metabolism, in vivo studies did not demonstrate decreased elimination by these isozymes; they contribute to only a small fraction of total body clearance. In vitro studies demonstrated that paliperidone is a P-gp substrate [see DRUG INTERACTIONS].
Co-administration of oral paliperidone extended-release 6 mg once daily with carbamazepine, a strong inducer of both CYP3A4 and P-gp, at 200 mg twice daily caused a decrease of approximately 37% in the mean steady-state Cmax and AUC of paliperidone. This decrease is caused, to a substantial degree, by a 35% increase in renal clearance of paliperidone. A minor decrease in the amount of drug excreted unchanged in the urine suggests that there was little effect on the CYP metabolism or bioavailability of paliperidone during carbamazepine co-administration [see DRUG INTERACTIONS].
Co-administration of a single dose of oral paliperidone extended-release 12 mg tablet with divalproex sodium extended-release tablets (two 500 mg tablets once daily at steady-state) resulted in an increase of approximately 50% in the Cmax and AUC of paliperidone. Although this interaction has not been studied with INVEGA SUSTENNA®, a clinically significant interaction would not be expected between divalproex sodium and INVEGA SUSTENNA® intramuscular injection [see DRUG INTERACTIONS].
Paliperidone is metabolized to a limited extent by CYP2D6. In an interaction study in healthy subjects in which a single 3 mg dose of oral paliperidone extended-release was administered concomitantly with 20 mg per day of paroxetine (a potent CYP2D6 inhibitor), paliperidone exposures were on average 16% (90% CI: 4, 30) higher in CYP2D6 extensive metabolizers. Higher doses of paroxetine have not been studied. The clinical relevance is unknown.
Specific Populations
Renal Impairment
INVEGA SUSTENNA® has not been systematically studied in patients with renal impairment. Based on a limited number of observations with INVEGA SUSTENNA® in subjects with mild renal impairment and pharmacokinetic simulations, the dose of INVEGA SUSTENNA® should be reduced in patients with mild renal impairment; INVEGA SUSTENNA® is not recommended in patients with moderate or severe renal impairment. Although INVEGA SUSTENNA® was not studied in patients with moderate or severe renal impairment, the disposition of a single oral dose paliperidone 3 mg extended-release tablet was studied in subjects with varying degrees of renal function. Elimination of paliperidone decreased with decreasing estimated creatinine clearance. Total clearance of paliperidone was reduced in subjects with impaired renal function by 32% on average in mild (CrCl = 50 mL/min to < 80 mL/min), 64% in moderate (CrCl = 30 mL/min to < 50 mL/min), and 71% in severe (CrCl = 10 mL/min to < 30 mL/min) renal impairment, corresponding to an average increase in exposure (AUCinf) of 1.5 fold, 2.6 fold, and 4.8 fold, respectively, compared to healthy subjects [see DOSAGE AND ADMINISTRATION and Use in Specific Populations].
Hepatic Impairment
INVEGA SUSTENNA® has not been studied in patients with hepatic impairment. Based on a study with oral paliperidone in subjects with moderate hepatic impairment (Child-Pugh class B), no dose adjustment is required in patients with mild or moderate hepatic impairment. In the study with oral paliperidone in subjects with moderate hepatic impairment (Child-Pugh class B), the plasma concentrations of free paliperidone were similar to those of healthy subjects, although total paliperidone exposure decreased because of a decrease in protein binding. Paliperidone has not been studied in patients with severe hepatic impairment [see Use in Specific Populations].
No dosage adjustment is recommended based on age alone. However, dose adjustment may be required because of age-related decreases in creatinine clearance [see Renal Impairment above and DOSAGE AND ADMINISTRATION].
No dosage adjustment is recommended based on race. No differences in pharmacokinetics were observed between Japanese and Caucasians.
No dosage adjustment is recommended based on gender, although slower absorption was observed in females in a population pharmacokinetic analysis.
No dosage adjustment is recommended based on smoking status. Based on in vitro studies utilizing human liver enzymes, paliperidone is not a substrate for CYP1A2; smoking should, therefore, not have an effect on the pharmacokinetics of paliperidone.
Clinical Studies
The efficacy of INVEGA SUSTENNA® was established in the following adequate and well-controlled trials:
- Four short-term, fixed-dose trials and one maintenance trial in adults with schizophrenia as monotherapy [see section below on Schizophrenia]
- One long-term, flexible-dose maintenance trial in adults with schizoaffective disorder as monotherapy or as adjunctive therapy to a mood stabilizer or antidepressant [see section below on Schizoaffective Disorder]
Short-Term Monotherapy (Studies 1, 2, 3, 4)
The efficacy of INVEGA SUSTENNA® in the acute treatment of schizophrenia was evaluated in four short-term (one 9-week and three 13-week) double-blind, randomized, placebo-controlled, fixed-dose studies of acutely relapsed adult inpatients who met DSM-IV criteria for schizophrenia. The fixed doses of INVEGA SUSTENNA® in these studies were given on days 1, 8, and 36 in the 9-week study, and additionally on day 64 of the 13-week studies, i.e., at a weekly interval for the initial two doses and then every 4 weeks for maintenance.
Efficacy was evaluated using the total score on the Positive and Negative Syndrome Scale (PANSS). The PANSS is a 30 item scale that measures positive symptoms of schizophrenia (7 items), negative symptoms of schizophrenia (7 items), and general psychopathology (16 items), each rated on a scale of 1 (absent) to 7 (extreme); total PANSS scores range from 30 to 210.
In Study 1 (PSY-3007), a 13-week study (n=636) comparing three fixed doses of INVEGA SUSTENNA® (initial deltoid injection of 234 mg followed by 3 gluteal or deltoid doses of either 39 mg/4 weeks, 156 mg/4 weeks or 234 mg/4 weeks) to placebo, all three doses of INVEGA SUSTENNA® were superior to placebo in improving the PANSS total score.
In Study 2 (PSY-3003), another 13-week study (n=349) comparing three fixed doses of INVEGA SUSTENNA® (78 mg/4 weeks, 156 mg/4 weeks, and 234 mg/4 weeks) to placebo, only 156 mg/4 weeks of INVEGA SUSTENNA® was superior to placebo in improving the PANSS total score.
In Study 3 (PSY-3004), a third 13-week study (n=513) comparing three fixed doses of INVEGA SUSTENNA® (39 mg/4 weeks, 78 mg/4 weeks, and 156 mg/4 weeks) to placebo, all three doses of INVEGA SUSTENNA® were superior to placebo in improving the PANSS total score.
In Study 4 (SCH-201), the 9-week study (n=197) comparing two fixed doses of INVEGA SUSTENNA® (78 mg/4 weeks and 156 mg/4 weeks) to placebo, both doses of INVEGA SUSTENNA® were superior to placebo in improving PANSS total score.
A summary of the mean baseline PANSS scores along with the mean changes from baseline in the four short-term acute schizophrenia studies are provided in Table 13.
Table 13: Schizophrenia Short-term Studies
|Study Number
|Treatment Group
|Primary Efficacy Measure: PANSS Total Score
|Mean Baseline Score
|LS Mean Change from Baseline
|Placebo-subtracted Differencea (95% CI)
|Study 1
(39 mg/4 weeks)*
(-9.01, -1.10)
(156mg/4 weeks)*
(-12.62, -4.78)
(234mg/4 weeks)*
(-13.71, -5.85)
|Study 2b
(78 mg/4 weeks)
(-8.73, 1.77)
(156mg/4 weeks)*
(-12.12, -1.68)
|Study 3
(39 mg/4 weeks)*
(-11.40, -1.73)
(78 mg/4 weeks)*
(-10.76, -1.07)
(156mg/4 weeks)*
(-14.07, -4.43)
|Study 4
(78 mg/4 weeks)*
(-16.85, -5.57)
|INVEGA SUSTENNA®(156 mg/4 weeks)*
(-19.51, -8.58)
|SD: standard deviation; SE: standard error; LS Mean:
least-squares mean; CI: unadjusted confidence interval.
a Difference
(drug minus placebo) in least-squares mean change from baseline.
b Because an insufficient number of subjects received the 234 mg/4 weeks dose, results from this group are not included.
* p < 0.05
(Doses statistically significantly superior to placebo).
Maintenance Monotherapy Treatment (Study 5: PSY-3001)
The efficacy of INVEGA SUSTENNA® in maintaining symptomatic control in schizophrenia was established in a longer-term double-blind, placebo-controlled, flexible-dose study involving adult subjects who met DSM-IV criteria for schizophrenia. This study included a minimum 12-week, fixed-dose stabilization phase, and a randomized, placebo-controlled phase to observe for relapse. During the double-blind phase, patients were randomized to either the same dose of INVEGA SUSTENNA® they received during the stabilization phase, i.e., 39 mg, 78 mg, or 156 mg administered every 4 weeks, or to placebo. A total of 410 stabilized patients were randomized to either INVEGA SUSTENNA® or to placebo until they experienced a relapse of schizophrenia symptoms. Relapse was pre-defined as time to first emergence of one or more of the following: psychiatric hospitalization, ≥ 25% increase (if the baseline score was > 40) or a 10-point increase (if the baseline score was ≤ 40) in total PANSS score on two consecutive assessments, deliberate self-injury, violent behavior, suicidal/homicidal ideation, or a score of ≥ 5 (if the maximum baseline score was ≤ 3) or ≥ 6 (if the maximum baseline score was 4) on two consecutive assessments of the specific PANSS items. The primary efficacy variable was time to relapse. A pre-planned interim analysis showed a statistically significantly longer time to relapse in patients treated with INVEGA SUSTENNA® compared to placebo, and the study was stopped early because maintenance of efficacy was demonstrated. Thirty-four percent (34%) of subjects in the placebo group and 10% of subjects in the INVEGA SUSTENNA® group experienced a relapse event. There was a statistically significant difference between the treatment groups in favor of INVEGA SUSTENNA®. A Kaplan-Meier plot of time to relapse by treatment group is shown in Figure 1. The time to relapse for subjects in the placebo group was statistically significantly shorter than for the INVEGA SUSTENNA® group. An examination of population subgroups did not reveal any clinically significant differences in responsiveness on the basis of gender, age, or race.
Figure 1: Kaplan-Meier Plot of Cumulative
Proportion of Subjects with Relapse Over Time (Schizophrenia Study 5)
Schizoaffective Disorder
Maintenance Treatment – Monotherapy And As Adjunct To Mood Stabilizer Or Antidepressant (SAff Study 1: SCA-3004)
The efficacy of INVEGA SUSTENNA® in maintaining symptom control in schizoaffective disorder was established in a long-term double-blind, placebo-controlled, flexible-dose randomized-withdrawal study designed to delay relapse in adult subjects who met DSM-IV criteria for schizoaffective disorder, as confirmed by the Structured Clinical Interview for DSMIV Disorders. The population included subjects with schizoaffective bipolar and depressive types. Subjects received INVEGA SUSTENNA® either as monotherapy or as an adjunct to stable doses of antidepressant or mood stabilizers.
This study included a 13-week, open-label, flexible-dose (INVEGA SUSTENNA® 78 mg, 117 mg, 156 mg, or 234 mg) lead-in period which enrolled a total of 667 subjects who had 1) acute exacerbation of psychotic symptoms; 2) score ≥ 4 on ≥ 3 PANSS items of delusions, conceptual disorganization, hallucinatory behavior, excitement, suspiciousness/persecution, hostility, uncooperativeness, tension, and poor impulse control; and 3) prominent mood symptoms ≥ 16 on the Young Mania Rating Scale (YMRS) and/or the Hamilton Rating Scale for Depression, 21-item version (HAM-D-21). Subjects were 19 to 66 years old (mean 39.5 years) and 53.5% were male. The mean scores at open-label enrollment of PANSS total was 85.8 (range 42 to 128), HAM-D-21 was 20.4 (range 3 to 43), YMRS was 18.6 (range 0 to 50), and CGI-SSCA was 4.4 (range 2 to 6).
After the 13-week open-label flexible-dose INVEGA SUSTENNA® treatment, 432 subjects met stabilization criteria (PANSS total score ≤ 70, YMRS ≤ 12, and HAM-D-21 ≤ 12) and continued into the 12-week open-label fixed-dose stabilization period.
A total of 334 subjects who met stabilization criteria for 12 consecutive weeks were randomized (1:1) to continue the same dose of INVEGA SUSTENNA® or to placebo in the 15-month, double-blind, maintenance period. For the 164 subjects who were randomized to INVEGA SUSTENNA®, dose distribution was 78 mg (4.9%), 117 mg (9.8%), 156 mg (47.0%), and 234 mg (38.4%). The primary efficacy variable was time to relapse. Relapse was defined as the first occurrence of one or more of the following: 1) psychiatric hospitalization; 2) intervention employed to avert hospitalization; 3) clinically significant self-injury, suicidal or homicidal ideation or violent behavior; 4) a score of ≥ 6 (if the score was ≤ 4 at randomization) of any of the individual PANSS items: delusions, conceptual disorganization, hallucinatory behavior, excitement, suspiciousness/persecution, hostility, uncooperativeness, or poor impulse control; 5) on two consecutive assessments within 7 days: ≥ 25% increase (if the score at randomization was > 45) or ≥ 10-point increase (if the score at randomization was ≤ 45) in total PANSS score; a score of ≥ 5 (if the score was ≤ 3 at randomization) of any of the individual PANSS items: delusions, conceptual disorganization, hallucinatory behavior, excitement, suspiciousness/persecution, hostility, uncooperativeness, or poor impulse control; an increase of ≥ 2 points (if the score was 1 [not ill] to 3 [mildly ill] at randomization) or increase of ≥ 1 point (if the score was ≥ 4 [moderately ill or worse] at randomization) in CGI-S-SCA overall score.
There was a statistically significant difference in time to relapse between the treatment groups in favor of INVEGA SUSTENNA®. A Kaplan-Meier plot of time to relapse by treatment group is shown in Figure 2.
Figure 2: Kaplan-Meier Plot of Cumulative
Proportion of Subjects with Relapse Over Time (SAff Study 1)
Table 14 summarizes the number of subjects with relapse in the overall population, by subgroup (monotherapy vs. adjunctive therapy), and by symptom type at the first occurrence of relapse.
Table 14: Summary of Relapse Rates (SAff Study 1)
|All Subjects
|57 (33.5%)
|25 (15.2%)
|Monotherapy subset
|24 (32.9%)
|9 (11.5%)
|Adjunct to Antidepressants or Mood Stabilizer subset
|33 (34.0%)
|16 (18.6%)
|Psychotic Symptomsa
|53 (31.2%)
|21 (12.8%)
|Mood Symptomsb
|Any Mood Symptoms
|48 (28.2%)
|18 (11.0%)
|16 (9.4%)
|5 (3.0%)
|23 (13.5%)
|8 (4.9%)
|9 (5.3%)
|5 (3.0%)
|a 8 subjects experienced a relapse without
psychotic symptoms.
b 16 subjects experienced a relapse without any mood symptoms.
Last reviewed on RxList: 4/13/2016
This monograph has been modified to include the generic and brand name in many instances.
Invega Sustenna FDA Prescribing Information
Additional Invega Sustenna Information
- Invega Sustenna Drug Interactions Center: paliperidone palmitate im
- Invega Sustenna Side Effects Center
- Invega Sustenna Overview including Precautions
- Invega Sustenna FDA Approved Prescribing Information including Dosage
Invega Sustenna - User Reviews
Invega Sustenna User Reviews
Now you can gain knowledge and insight about a drug treatment with Patient Discussions.
Here is a collection of user reviews for the medication Invega Sustenna sorted by most helpful.
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LUBBOCK — Texas Tech weathered a sluggish first half to overcome Eastern Illinois, 85-71, on Thursday in the first round of the Women's National Invitation Tournament at United Spirit Arena.
The Lady Raiders led by 16 midway through the first half and then went without a field goal for 8 minutes, 18 seconds.
The Panthers rallied to take a 36-35 lead with a minute to go in the half before Texas Tech found its way.
Shauntal Nobles set a career-high with 18 points and notched her third double-double of the season with 11 rebounds.
Casey Morris added 17 points for the Lady Raiders and had three 3-pointers in the first four minutes.
Eastern Illinois' Ta'Kenya Nixon led all scorers with 25 points.
The Lady Raiders advance to face Tulane in the second round. The time, date and location of that game have not been determined.
Tech (20-13) and Eastern Illinois (22-9) each had 15 rebounds in the first half, but the Panthers had only 11 in the second half. Tech had 27 in the second half and converted 17 offensive rebounds into 19 second-chance points.
The Lady Raiders shot 50 percent in the game, the second time they've shot 50 percent or better in the last four games.


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The past few years have seen some amazing classic cars unearthed, hidden away in barns, sheds, parking lots, and scrap yards only to be rediscovered.
Chevrolet News
652Kansas cops save puppy from sweltering car
- Jason Marker
- Jul 12, 2016
- 652
Police in Merriam, Kansas saved the life of a small puppy by extracting it from a sweltering SUV.
272017 Chevy SS could get supercharged power boost
- Brandon Turkus
- Jul 8, 2016
- 27
The Australian Holden Commodore's horsepower has grown over the years, but America's Chevy SS hasn't received the same attention. That could change in 2017.
34Junkyard Gem: 1992 Chevrolet Lumina Z34
- Murilee Martin
- Jul 8, 2016
- 34
Most Chevy Luminas were rental-car-grade transportation appliances, but the Z34 was a bit more interesting. Here's a discarded one.
192017 North American Car, Truck, and Utility of the Year entries announced
- Brandon Turkus
- Jul 6, 2016
- 19
There are some absurd entries in this year's competition – Rolls-Royce Dawn, anyone? – but plenty of mainstream metal. Finalists will be announced December 6.
12Watch Tony Stewart's amazing last-lap battle at Sonoma
- Reese Counts
- Jun 27, 2016
- 12
Sonoma Raceway, one of NASCAR's two road-courses, shows that occasionally going right can be just as exciting as going left.
104Mid-engine Chevy Corvette captured in broad daylight
- Brandon Turkus
- Jun 27, 2016
- 104
The next Corvette has advanced rapidly beyond the mule stage, and is already in a very early pre-production trim.
60With only 57 miles, this is essentially a brand-new 2003 Corvette
222017 Chevy Camaro ZL1 has line lock for sweet burnout mode
- Michael Austin
- Jun 26, 2016
- 22
As if the line lock feature on the 2017 Chevy Camaro ZL1 wasn't sweet enough, the way it was revealed was even better. Running up the hill at the 2016 Goodwood Festival of Speed, GM Global Lead for Product Development chief Mark Reuss stopped on the track, activated the function, and left the crowd "swaythed in factory rubber smoke" to quote the British announcers. The function is activated through the launch control menu when the car is in Track mode and the transmission is in Drive or first g
10Lawsuit alleges Chevy Cruze Diesels use VW TDI-like cheat
- Sebastian Blanco
- Jun 24, 2016
- 10
A class-action suit against GM over the Chevy Cruze Diesel alleges it has emissions cheat software like VW used in its TDI models.
69Question of the Day: Worst year of the Malaise Era?
- Murilee Martin
- Jun 23, 2016
- 69
Giant, hideous crash bumpers, engines that made 25 horsepower per liter, and velour. Lots of velour. 1973 through 1983, which year was the Malaise nadir?
Tesla Model S wins Strategic Vision Total Quality Impact award
- Brandon Turkus
- Jun 22, 2016
Strategic Vision's Total Quality Impact awards go to vehicles based on survey responses while also focusing on the intangible aspects of vehicle ownership.
3Massachusetts town abuzz over bees in car trunk
- Jason Marker
- Jun 22, 2016
- 3
Authorities in Fitchburg, Massachusetts believe that a bee hive was stashed in the trunk of a parked car with malicious intent.
6Four classic American trucks on new stamps because America
- Reese Counts
- Jun 17, 2016
- 6
These new Forever stamps will, uh, help haul the mail.
862017 Honda Ridgeline enters the landscape block war
- Jeremy Korzeniewski
- Jun 12, 2016
- 86
How does the composite bed of the 2017 Honda Ridgeline compare to the steel bed of the Chevy Silverado and aluminum bed of the Ford F-150? Let's find out.
162Chevy throws (landscaping) stones at Ford F-150
- Greg Migliore
- Jun 8, 2016
- 162
Chevy fires the latest salvo in the the Silverado vs. Ford F-150 war.
30Bumblebee returns as 2016 Chevy Camaro in Transformers 5
- Jeremy Korzeniewski
- Jun 5, 2016
- 30
Bumblebee will always be a VW Beetle, no matter what Michael Bay says.
- Volvo shoots for self-drivers by 2021
- Jeep spends $1 billion on factories
- Find Parts & Accessories for your vehicle!
- Obama rolls out new EV plan
- Infiniti dealers ranked best, Tesla worst
- Compare Volvo XC90 and Lincoln MKX


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The therapeutic need of high protein dietary intake has been recognized by both surgeons and clinicians for many years. For the internist,1 above-normal protein intakes by patients are essential in the treatment of many diseases characterized by hypoproteinemia, such as starvation, nephrosis,2 sprue, pellagra, chronic colitis, certain liver afflictions,3 and anorexia from a variety of causes. Also, high protein intake is often beneficial in the treatment of diseases in which protein catabolism is increased such as in thyrotoxicosis and prolonged high fevers. To the surgeon, a high protein intake has been associated with adequate wound healing and speedy convalescence.4 And the geriatrician, who is faced by dietary problems peculiar to the age of his patients, finds adequate protein ingestion a preventative necessity.5 Not least, the pediatrician is ever mindful of the importance of sufficient protein to meet growth as well as metabolic needs of the
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After some frustrating efforts we found a simple fix for a set of pages that would often not load at all, and were at the same time seeing bandwidth usage shoot through the roof for no obvious reason.
If you're linking to a page containing WordPress Post Tabs, the link must have a trailing slash. Otherwise it can cause an infinite loop of embedded loading pages within the tabbed area.
We didn't see this at first because our Firefox automatically adds trailing slashes, but Chrome and IE don't.
I hope this helps someone else out!


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Secondary menu
England escape from Old Trafford with an underwhelming draw and lots to worry about
Where were the bouncers? Where were the tactics? Not Alastair Cook's finest day as England captain
Those who wrote off Australia must eat their words: on the other hand, could history repeat itself?
Some wonder if the Aussie cricketers will give England a game, others fear they could spring a surprise
England are being tipped to win, but could Australia's cricketers spring a surprise this summer?
Young Yorkshire batsman came into the team only last December but has already proved his ability
England lose yet another one-day final but once again Australia steal the headlines
Questions remain over England's ruthlessness after they almost let South Africa off the hook
Weather worries as England must beat New Zealand in Cardiff to advance to Champions Trophy semis
England's 'irritable' cricketers come under fire even though Australia curtain-raiser ends in victory
A hundred for Prior and stout resistance from Ian Bell and Stuart Broad secure unlikely result
England on brink of series defeat to New Zealand - but at least we're not as bad as the Aussies
England played with the 'brains of a chocolate mouse' says Geoff Boycott at end of humiliating day of cricket
Centuries for Jonathan Trott and Ian Bell cap a remarkable turnaround for England's cricketers
England cricket captain has re-written records in Calcutta - with more to come
Star batsman's return to England fold surprised many observers – but Cook has shown he's a clever captain
Spin bowler Monty Panesar builds on batsman Kevin Pietersen's heroic 186 to level the series
England keen to 'draw a line' under saga of the provocative text messages slagging off colleagues
KP could be even more isolated now Strauss has gone, amid rumours of a career in politics


text:
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Britney Spears in Designer jeans
Favorite Celeb Outfit: Britney Spears
We see the celebs wear so many different outfits, we thought it would be fun if our readers got to pick their favorite! Here are all the various outfits we have blogged Britney Spears in and please vote for your favorite! We mean your favorite by her head to toe outfit, not just her jeans! What do you think she looks best in? (Note: if you like these blogs, they are published on Mondays, so you can keep your eye out for them!)
If you hover your mouse over the pictures they each have a number assigned to them for the poll.
Britney Spears in True Religion
Fresh off of her appearance on Glee, Britney Spears unwinds by doing some shopping. Britney stopped by the Only Hearts Boutique in Santa Monica, CA for some vintage shopping. I guess she found something she liked because she ended up leaving the store in a different outfit than she entered in.
Britney's first outfit consisted of an over-sized sweater and a pair of True Religion Jeans, our Denim Brand of the Month. I'm usually not a fan of Britney's style but I think this could have been salvaged if her jeans were hemmed and fit a little bit better. You can buy True Religion jeans here.
Britney Spears in True Religion
Britney Spears heads to lunch in Calabasas, California. Britney looked to be all smiles, perhaps about her upcoming appearance on Glee. She will be appearing on the hit show next Tuesday and even Tweeted about it. Check out her tweets here.
Britney looked ready for fall, in a pair of black pants, a button up and boots. Britney was wearing her trusty True Religion jeans. She's been spotted out in True Religion jeans quite a few times. I think these are a great look for her, I used to be against mixing black and brown but I think it can look chic, especially with the right shade. You can purchase True Religion jeans here.
Britney Spears in Siwy
Britney Spears and her boyfriend Jason Trawick were caught on a relaxing vacation in Hawaii. The two were seen playing in the surf in Maui and looked to be having a great time. Britney looks so happy, she hasn't looked this good in a long time!
Britney looked tan and toned in a pink striped bikini and a pair of light wash denim shorts. Britney's shorts are the Camilla cut off denim shorts in Snowstorm by Siwy Denim. Both Britney and Miley Cyrus have been seen wearing these shorts before. You can buy Siwy shorts at Singer22.com for $152.


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Deep Thought is done thinking.
Deep Thought will take the eVent Packa.
Type: Posts; User: Deep Thought
Deep Thought is done thinking.
Deep Thought will take the eVent Packa.
If you count Lofty, Alf233 and myself, that's three orders (only? at least?) on their way to Canada.
I'm curious to watch the shipping time/customs turn-around time--especially before/after...
It will be worth the wait!!
They start shipping orders that are in stock and ready to go, then it's priority shipping to those who have booked a trip and need it pronto.
Seeing order numbers higher...
I see you've got the pump cap on there.
No pump or original cap?
These were the hairpin turns in the trail, up and around trees/rocks, that made it an advantage to have a sled on ropes. It allowed me to pull the sled up close and pull hard on one side to drag it...
Finally added the pictures!
Sorry it took so long to get them up.
We all made excellent time to Algonquin Park's West Gate on Friday February 15th.
We had decided to meet at 11am, and I rolled into the parking lot at 10:59am to find Hankster walking up the parking...
There be a trick to it.
Always empty spit valves and keep the mouthpiece in your pocket. I also boil up some tea while I play.
Fingers going numb is more of a...
-30 on Monday morning??? Nooooooo!!! why did I have to leave??? :(
Still, minus-whatever, it was fun hanging with you guys.
Did you get my message on your way out?
Some info:
Winter expedition info:
Mizzy Lake Trail is located at km 15.4 of Highway...
Martin: Bring whatever you can scrounge up for warmth so you can at least hang your new Hennessy (show it off!!) and try a nap while you're visiting during the day.
It wouldn't do to have you hike...
Here is a picture I took of the area from my Basemap program using Ibycus 3.2 Topo.
*Note, My Ontario Trails GPS map and my Algonquin Park map shows that the Mizzy...
I'd like to thank all those intrepid explorers and those people with knowledge of the area. I wish I knew the area better to add my two cents.
All I can say about snowmobiles is, if you're...
Holy smokes Fronkey!!
Are we going to be getting a full-blown survival report with the legendary recovered footage?
It's gut-wrenching to hear about a cuben tarp ripped up. That wind up in Section...
Dwight, Ontario, closest LCBO to Niger Lake, Ontario.
Average high of -2.7
Average low of -14.9
Record high 12.5 (1984)
Record low -37.5 (1987)
-34 tonight, feels like -38
Wouldn't it be...
Sorry to hear about your ankle Keg!
I'm subscribed and will be following this. I'm interested, but waiting to hear back on time off requests.
I just read through the thread for the Frozen Butt...
Hey Keg
Hope your Hammock Gear order pulled off a Christmas Eve miracle!
My order took 2.5 days to clear customs with the dreaded tax paperwork, so your package's 4 minutes in customs may be really...
I tried the stock Deep Jungle XL with the reflector pad on a windy and snowy 0 degree night (32F). I had to bail around 2AM when it became pretty uncomfortable on the underside.
I could have...
I'll take it if that falls through.
StumpJumper would be angry that you put a hole in the hip belt pocket...
Yup. The technique is important (honed after many years of packages and a few early years as a grocery clerk). Slice the sides, pull the top flaps up and away from the box and then cut that. Just...
I hope you took pictures!!
I see a lot of all-black under quilts, but I had to go green outer/black inner. I'm curious about other people's fashion choices. Was black on black the big seller this...
For those of you eagerly awaiting your downy goodness...
Here are some teasers.
Was customs kind to you with your Hammock Gear order, Barlutti? (congrats on your new incubator!)
I noticed that the usual Canada Post $5 handling fee I've paid in the past was $9.95 on this...
Following order numbers won't help much and could be downright confusing or frustrating. Best to ignore it. As I understand it, depending on the items ordered and the priority, some orders will get...
Hahaha I can't believe I missed that post. Bullied...right.
You'll thank me at the next hang ;)
I've found many postal workers running the counters here at Canada Post to be slightly...un-helpful (can't speak for USPS). Then again, they're not mind-readers and you can't expect them to know...
Those customs officers in Mississauga must be "WTF is with all this down crossing the border???" FLAG! FLAG! FLAG!! (for duty/tax)
My order cleared customs Tuesday morning, so maybe you caught a...
Hey Keg,
Is that the one you ordered at the Valens hang?
My black friday HG order made it out of Mississauga yesterday and it's waiting at the post office...pending taxes...some $35
(duty/tax +...
I love me whoopies and Marlin Spike hitch :)
Personally, I've never liked the way buckles pinched the webbing in one spot.
I've had some rings shear through some cheap polypro webbing from...
Can you melt folds into the pad (alternating top and bottom) with a hot knife or soldering iron to turn your cheap ccf roll up into a z-rest-type folding pad?
If so, how deep can you melt the...
Do I hear an Ontario group-buy in the works?? :)
Or the start of an online petition for Len's Mill?
Congratulations on your December hang at Rattlesnake!
Nice pictures!
Did you end up at site #3? Sorry to hear that you had trouble finding suitable trees. On the other hand, hanging on a hillside...
It was a great time with some great people.
I loved the chance to check out all the different rigs and I was amazed to see the latest in tarp technology.
That cuben fiber is pretty awesome!
I was...
Hello and welcome from Toronto!
Echo what Chard and Bubba said.
Lots of options for winter hanging besides underquilts. Pads and an old winter sleeping bag have worked for me in the past--and...
I hope everyone got home safe!!
I stayed back for a little while, ate some clementines and pulled out the horn and played some Christmas carols. Left around 1pm.
I had a great time hanging out...
I'm off to see site 134, but I'll talk to the gate attendant and add myself to whichever site isn't full. Can't wait!!
I couldn't resist this offer!
Had to have a legendary Incubator. Another order bound for Canada :)
Thanks for the sale!
Deep Thought
Did I count 18 people on that role call list??
I believe Jiblets posted attendance for both nights.
Can I make it an even 20?
I just got last minute approval to hang. I'm in for Saturday.
I will...
But still raises some questions, is the hyperlight the best Hammock, I want to use rings to hang it and the hyperlight has a very thin rope and minimum load carrying, what if I need to share my...
I think this is one of the greatest features of your videos, Shug. It helps to knit the community together so we can respect each other (and our differing options) and continue to spread the love of...
To be clear, the fly in question is a HH Hyperlite silnylon fly, 4+ years old. The whole underside of the rain fly is pretty "rubbery", not just along the seams (if it was seam-sealer). It's not...
Thanks for the talcum powder idea and the warning about cornstarch/baby powder!
I just knew there would be a wealth of wisdom here in this forum.
will these work with 1.5 inch webbing?
I've got a Hennessy Hyperlite rain fly and the underside of the fly sticks to itself something fierce.
When I take it out of the snake skins, parts of it are practically glued together and make an...
I've got one just like it with my Hyperlite. It's a great rain fly.
The Hyperlite rain fly is for the sensible minimalist.
It's a tiny tarp, but it covers you right where you need it. Perfect for...
Echo that thanks to Bubba for the heads-up!
I'm interested in this hang. I'll look into getting the weekend off work.
Just got back from hanging this past weekend. Not too cold, but pretty wet. ...
will you take market value of aluminum + shipping?
**as of 1:32am Oct 1**
Here is the opening list of our annual Odds and Ends sale. If you
have any questions or would like to order something listed below,
please let us know by emailing...
AFAIK down creates warmth by lofting and creating dead-air space that provides insulation, is that right? So it's the air that does the insulating and not the down fibers themselves?
When there is...
It may be a little late, but this post may help others searching for the same answers (as I was this morning).
Marmot does a great tour of their down testing lab available here:...


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For the buffer system described in Problem 8.79, which substance is responsible for buffering capacity against added hydrochloric acid? Explain.
(Problem 8.79)
For the equilibrium situation involving acetic acid,
explain the equilibrium shift occurring for the following changes:
a. A strong acid is added to the solution.
b. The solution is diluted with water.


text:
Film Golden Globes
posted by January 13 at 20:59 PMon
The big winners at this year's non-event were Atonement for best drama and Sweeney Todd for best comedy or musical. Julian Schnabel for direction is a mild surprise, but the acting awards went to everyone you expected. Complete lineup here.
The local angle: Eddie Vedder won for best original song—and somehow we managed to review the best motion picture made for television winner in the DVD column. Sean Nelson didn't like it.
And the Jane Austen series on Masterpiece Theatre begins… now!


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I was very kindly given this to read by Headline and decided to read it when we were having lovely sunny weather, and it completely transported me to the Italian countryside.
The plotline
After a miserable break-up with her long-term boyfriend, Ruthie Collins drunkenly spends her half of the flat sale money on a run down farmhouse.....in Italy......on ebay. As you may already know, I am not an avid reader of 'chic-lit' novels, and the romance element seemed as predictable as they all generally are, the description of life in Italy, the culture, the people, the food, everything, was fantastic and spot on. You will 100% be transported to the beautiful rolling hills of Italy when you read this book, I promise. I started early on to daydream about buying my very own rundown farmhouse in Italy with my very own Italian love God...I digress.
When Ruthie turns up to her farmhouse in the pouring rain, she is shocked to discover just how much work she will have to do. She is also greeted by a goat who thinks he owns the property and a very angry neighbour.As she starts to realise just how much time, effort and money will be needed to make the house liveable again, she starts to wonder if she has made a terrible mistake. Her mother, boyfriend and brother have already made it clear to her that they think it is a crazy idea for her to by the house in Italy. As she slowly begins to settle in and work on her new home she battles the locals, feeling lonely and the wrath of the family next door who believe the house is not hers to buy.
Along with the slightly predictable romance element which I still enjoyed, Ruthie starts to learn some life lessons, and find what truly makes her happy. If you want an easy read which transports you to Italy and all it's beauty. this is a great summer time read.


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Meet Molly: The Truth About Ecstasy
In this article the author talks about the drug Molly. Molly seems like a person but in a actuality molly is a nick name for MDMA also known as Ecstasy. In the article the author includes the example of how pop singer, Madonna asks a crowd of her fans if they have ever met Molly. The media and public became outraged at Madonna saying that she encouraged young adults to become reckless and use drugs. Later the pop star included that she does not condone Molly nor has ever used the drug herself. But what is Molly made from exactly? MDMA or Methylenedioxymethamphetamine is a man made drug made from many mixtures of chemicals and substances. "It's commonly used at dance clubs and concerts, and can make people feel like they have more energy and less fear." The author states that Molly is a dangerous drug because the person who makes the drug can put whatever ingredients they want to in them. And also the drug makes you extremely hyper and dehydrated which can cause you to have a seizure and possibly die.
I agree with this article because I think that the music industry should stop exploiting drugs if they are not about that life. I completely disagree with Madonna's judgment by talking about the drug to her fans. Young Adults that idolize their favorite celebs will become extremely curious about what they are talking about. Being a college student, i often hear about people my age using the popular drug. I often wonder what the purpose of the drug really is. There is a myth that the drug makes you become more sexually active while you are using. But is this true or just a myth. I believe that the drug ultimately does make your actions and body speed up when you're using it but i do not necessarily believe it influences someones actions. Heighten and increase the actions but change the actions, i do not think so.
How Well Do You Know Molly?
The author's purpose of this article is to talk about the popular drug Molly and informing it's readers about the side effects, consequences, and problems that occur when taking the drug. "Molly" or Ecstasy is a drug that contains MDMA. MDMA feeds the brain with "mood-enhancing neurotransmitters that cause the user to feel euphoric, and promotes a general feeling that all is right with the world." Surprisingly, the author states in the article that Many people do Molly because it is the least addicting drug to use. However, the drug can be laced or mixed with other drugs which can potentially become a huge problem and also very harmful the the human body. The drug is dangerous because it can also "cause rapid breathing and heart rate, and can cause the body's temperature to shoot up, causing seizures, strokes, coma, or even death."
guarantee like this blog because it talks about the dangers of using the drug. Most people just think that you have to keep your body hydrated in order to not have any medical problems however that is not the case. Molly can give you seizures and can cause death. The drug alone might slightly be less harmful than others but there is no guarantee that the drug you are taking is just Ecstasy by itself. What striked me a lot and what i found very interesting was that a lot of medical physicians say that the drug can cure tramua. But is it really worth the try? Should PTSD patients experiment with this drug? I personally so not think it is safe to use period. But others might disagree,
Can you die from taking Molly?This article is simply about the question if the harmful drug Molly, or Ecstasy is harmful enough to the point to where it can kill you? A lot of young adults that are substance abusers often ask that question to their peers. Being a college student i have witnessed a lot of students using drugs and talking about experimenting with Molly. But will this experimenting lead to death? The author initially states in the beginning of this article that, you can die from accidental overdosing on Molly. The author also talks about the effects such as hallucinating and experiencing a state of euphoria. Because it is known as the "club drug" Many people want to use the drug because it will increase their energy and enjoyment
I believe that this article was very informative unlike the other blogs. This blog article focuses on the medical side of using drugs instead of the social problem. Molly is a nickname for the popular drug Ecstasy. Ecstasy is a stimulant drug that many people think makes them want to have sex. In this article I learned that the drug is unfortunately very harmful to the body.


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Intro Astronomy 2014. Class 12: The Sun and Stars
Lecture 12 of Dr. Bruce Betts' 2014 online Introductory Planetary Science and Astronomy course covers the Sun (physical characteristics, zones, solar cycle, sunspots, flares, coronal mass ejections, fusion, etc.) and Stars and Stellar Evolution (star types and colors, evolution, HR Diagrams, birth and death phases, white dwarfs, neutron stars, black holes). Recorded at California State University Dominguez Hills.
Stefan Schotte: 08/31/2014 12:16 CDT
Dear Dr. Betts, Looking at the different sizes of the stars at their formation (small, medium; big; huge, 'ginormous'...) I was wondering if certain models have been defined that explain the differences in size during the creation and what kind of parameters that are used in these models: - quantity of material ('dust' in the nebulas) - kind of material (H mostly but maybe a supernova provided more of the heavier materials) - external impact (force to start the process eg shockwave of a supernova) etc.. Also is there free software available to simulate star creation ? BTW very cool introduction classes on astronomy. (From a Belgian guy living in France and very interested in Astronomy and space technology)
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NEW DELHI: India has set aside Pakistani interior minister Rehman Malik's request for an appointment with Congress President Sonia Gandhi, with MEA officials viewing it as "out of line" with protocol. However, a confirmation is still awaited on his requests for a meeting with PM Manmohan Singh and Leader of Opposition in the Lok Sabha Sushma Swaraj.
Sources in the government said that the MEA decided against even forwarding Malik's request to the Congress president's office. Though a meeting with the PM is yet to be scheduled, sources indicated that it may be a mere courtesy call.
Incidentally, Malik has not sought a visit to either Ajmer Sharief or Agra during his visit here from December 14 to 16. It be recalled that Malik had, during his talks with Union home minister Sushil Kumar Shinde in Rome, expressed his desire to visit the Ajmer shrine and the Taj Mahal. Sources indicated that the Pakistani side may be wary of negative publicity over Malik's trip to tourist destinations in India, when no credible action has been taken against 26/11 perpetrators based in Pakistan.
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Happy St. Patrick's Day!Chelsea Fuss
Happy St. Patrick's Day! Though the leaves on this print look almost like shamrocks, they are sweet geranium leaves. Still, the design feels very March 17th!
You can buy this gorgeous print from the textile mavens at Hable Construction who hand silk screened the poster. Lovely, right?
Photo: Hable Construction.
Article Posted 5 years Ago