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FDA Approves Trulicity to Treat Type 2 Diabetes »
"The U.S. Food and Drug Administration today approved Trulicity (dulaglutide), a once-weekly subcutaneous injection to improve glycemic control (blood sugar levels), along with diet and exercise, in adults with type 2 diabetes.
Type 2 diabet"...
Read the FDA Approves Trulicity to Treat Type 2 Diabetes article »
Mechanism of Action
Metformin is an antihyperglycemic agent which improves glucose tolerance in patients with type 2 diabetes, lowering both basal and postprandial plasma glucose. Its pharmacologic mechanisms of action are different from other classes of oral antihyperglycemic agents. Metformin decreases hepatic glucose production, decreases intestinal absorption of glucose, and improves insulin sensitivity by increasing peripheral glucose uptake and utilization. Unlike sulfonylureas, metformin does not produce hypoglycemia in either patients with type 2 diabetes or normal subjects (except in special circumstances, see PRECAUTIONS) and does not cause hyperinsulinemia. With metformin therapy, insulin secretion remains unchanged while fastingplasma insulin levels and day-long plasma insulin response may actually decrease.
Pharmacokinetics And Drug Metabolism
Absorption and Bioavailability
The appearance of metformin in plasma from a FORTAMET® (metformin hcl) Extended-Release Tablet is slower and more prolonged compared to immediate-release metformin. In a multiple-dose crossover study, 23 patients with type 2 diabetes mellitus were administered either 2000 mg FORTAMET® (metformin hcl) once a day (after dinner) or immediate-release (IR) metformin hydrochloride 1000 mg twice a day (after breakfast and after dinner). After 4 weeks of treatment, steady-state pharmacokinetic parameters, area under the concentration-time curve (AUC), time to peak plasma concentration (Tmax), and maximum concentration (Cmax) were evaluated. Results are presented in Table 1.
Table 1: FORTAMET® (metformin hcl) vs. Immediate-Release Metformin Steady-State Pharmacokinetic Parameters at 4 Weeks
| Pharmacokinetic
(mean ±SD)
| FORTAMET® (metformin hcl)
2000 mg
q.d.after dinner)
| Immediate-Release Metformin
2000 mg
(1000 mg b.i.d.)
| AUC 0-24 hr
|26,811 ± 7055
|27,371 ± 5,781
|Tmax (hr)
|6 (3-10)
|3 (1-8)
|Cmax (ng/mL)
|2849 ± 797
|1820 ± 370
In four single-dose studies and one multiple-dose study, the bioavailability of FORTAMET® (metformin hcl) 2000 mg given once daily, in the evening, under fed conditions [as measured by the area under the plasma concentration versus time curve (AUC)] was similar to the same total daily dose administered as immediate release metformin 1000 mg given twice daily. The geometric mean ratios (FORTAMET® (metformin hcl) / immediate-release metformin) of AUC0-24hr, AUC0-72hr, and AUC0-inf. for these five studies ranged from 0.96 to 1.08.
In a single-dose, four-period replicate crossover design study, comparing two 500 mg FORTAMET® (metformin hcl) tablets to one 1000 mg FORTAMET® (metformin hcl) tablet administered in the evening with food to 29 healthy male subjects, two 500 mg FORTAMET® (metformin hcl) tablets were found to be equivalent to one 1000 mg FORTAMET® (metformin hcl) tablet.
In a study carried out with FORTAMET® (metformin hcl) , there was a dose associated increase in metformin exposure over 24 hours following oral administration of 1000, 1500, 2000, and 2500 mg.
In three studies with FORTAMET® (metformin hcl) using different treatment regimens (2000 mg after dinner; 1000 mg after breakfast and after dinner; and 2500 mg after dinner), the pharmacokinetics of metformin as measured by AUC appeared linear following multiple-dose administration.
The extent of metformin absorption (as measured by AUC) from FORTAMET® (metformin hcl) increased by approximately 60% when given with food. When FORTAMET® (metformin hcl) was administered with food, Cmax was increased by approximately 30% and Tmax was more prolonged compared with the fasting state (6.1 versus 4.0 hours).
Distribution studies with FORTAMET® (metformin hcl) have not been conducted. However, the apparent volume of distribution (V/F) of metformin following single oral doses of immediate-release metformin 850 mg averaged 654 ± 358 L. Metformin is negligibly bound to plasma proteins, in contrast to sulfonylureas, which are more than 90% protein bound. Metformin partitions into erythrocytes, most likely as a function of time. At usual clinical doses and dosing schedules of immediate-release metformin, steady state plasma concentrations of metformin are reached within 24-48 hours and are generally < 1 µg/mL. During controlled clinical trials of immediate-release metformin, maximum metformin plasma levels did not exceed 5 µg/mL, even at maximum doses.
Metabolism and Excretion
Metabolism studies with FORTAMET® (metformin hcl) have not been conducted. Intravenous single-dose studies in normal subjects demonstrate that metformin is excreted unchanged in the urine and does not undergo hepatic metabolism (no metabolites have been identified in humans) nor biliary excretion.
In healthy nondiabetic adults (N=18) receiving 2500 mg q.d. FORTAMET® (metformin hcl) , the percent of the metformin dose excreted in urine over 24 hours was 40.9% and the renal clearance was 542 ± 310 mL/min. After repeated administration of FORTAMET® (metformin hcl) , there is little or no accumulation of metformin in plasma, with most of the drug being eliminated via renal excretion over a 24-hour dosing interval. The t1/2 was 5.4 hours for FORTAMET® (metformin hcl) .
Renal clearance of metformin (Table 2) is approximately 3.5 times greater than creatinine clearance, which indicates that tubular secretion is the major route of metformin elimination. Following oral administration, approximately 90% of the absorbed drug is eliminated via the renal route within the first 24 hours, with a plasma elimination half-life of approximately 6.2 hours. In blood, the elimination half-life is approximately 17.6 hours, suggesting that the erythrocyte mass may be a compartment of distribution.
Special Populations
Limited data from controlled pharmacokinetic studies of immediate-release metformin in healthy elderly subjects suggest that total plasma clearance of metformin is decreased, the half-life is prolonged, and Cmax is increased, compared to healthy young subjects. From these data, it appears that the change in metformin pharmacokinetics with aging is primarily accounted for by a change in renal function (Table 2). FORTAMET® (metformin hcl) treatment should not be initiated in patients ≥ 80 years of age unless measurement of creatinine clearance demonstrates that renal function is not reduced (see WARNINGS, PRECAUTIONS and DOSAGE AND ADMINISTRATION).
No pharmacokinetic data from studies of pediatric patients are currently available (see PRECAUTIONS).
Five studies indicated that with FORTAMET® (metformin hcl) treatment, the pharmacokinetic results for males and females were comparable.
Table 2: Select Mean (±SD) Metformin Pharmacokinetic Parameters Following Single or Multiple Oral Doses of Immediate-Release Metformin
| Subject Groups:
Metformin dosea
| Immediate-Release
(number of subjects)
| Cmaxb
|Healthy, nondiabetic adults
|500 mg single dose (24)
|1.03 (±0.33)
|2.75 (±0.81)
|600 (±132)
|850 mg single dose (74)d
|1.60 (±0.38)
|2.64 (±0.82)
|552 (±139)
|850 mg three times daily for 19 dosese
|2.01 (±0.42)
|1.79 (±0.94)
|642 (±173)
|Adults with type 2 diabetes:
|850 mg single dose (23)
|1.48 (±0.5)
|3.32 (±1.08)
|491 (±138)
|850 mg three times daily for 19 dosese
|1.90 (±0.62)
|2.01 (±1.22)
|550 (±160)
|Elderlyf, healthy nondiabetic adults:
|850 mg single dose (12)
|2.45 (±0.70)
|2.71 (±1.05)
|412 (±98)
|Renal-impaired adults: 850 mg single dose
|Mild (CLcrg 61-90 mL/min) (5)
|1.86 (±0.52)
|3.20 (±0.45)
|384 (±122)
|Moderate (CLcr 31-60 mL/min)
|4.12 (±1.83)
|3.75 (±0.50)
|108 (±57)
|Severe (CLcr 10-30 mL/min)
|3.93 (±0.92)
|4.01 (±1.10)
|130 (±90)
| a All doses given fasting except
the first 18 doses of the multiple dosestudies
b Peak plasma concentration
c Time to peak plasma concentration
d Combined results (average means) of five studies: mean age 32 years(range 23-59 years)
eKinetic study done following dose 19, given fasting
f Elderly subjects, mean age 71 years (range 65-81 years)
g CLcr = creatinine clearance normalized to body surface area of 1.73 m2
Renal Insufficiency
In patients with decreased renal function (based on measured creatinine clearance), the plasma and blood half-life of metformin is prolonged and the renal clearance is decreased in proportion to the decrease in creatinine clearance (Table 2; also see WARNINGS).
Hepatic Insufficiency
No pharmacokinetic studies of metformin have been conducted in patients with hepatic insufficiency.
No studies of metformin pharmacokinetic parameters according to race have been performed. In controlled clinical studies of immediate-release metformin in patients with type 2 diabetes, the antihyperglycemic effect was comparable in whites (n=249), blacks (n=51), and Hispanics (n=24).
Clinical Studies
In a double-blind, randomized, active-controlled, multicenter U.S. clinical study, which compared FORTAMET® (metformin hcl) q.d. to immediate-release metformin b.i.d., 680 patients with type 2 diabetes who had been taking metformin-containing medication at study entry were randomly assigned in equal numbers to double-blind treatment with either FORTAMET® (metformin hcl) or immediate-release metformin. Doses were adjusted during the first six weeks of treatment with study medication based on patients' FPG levels and were then held constant over a period of 20 weeks. The primary efficacy endpoint was the change in HbA1c from baseline to endpoint. The primary objective was to demonstrate the clinical non- inferiority of FORTAMET® (metformin hcl) compared to immediate-release metformin on the primary endpoint. FORTAMET® (metformin hcl) and metformin patients had mean HbA1c changes from baseline to endpoint equal to +0.40 and +0.14, respectively (Table 3).The least-square (LS) mean treatment difference was 0.25 (95% CI = 0.14, 0.37) demonstrating that FORTAMET® (metformin hcl) was clinically similar to metformin according to the pre-defined criterion to establish efficacy.
Table 3: FORTAMET® (metformin hcl) vs. Immediate-Release Metformin Switch Study: Summary of Mean Changes in HbA1c, Fasting Plasma Glucose, Body Weight, Body Mass Index, and Plasma Insulin
| Immediate
| Treatment
difference for
change from
(FORTAMET® (metformin hcl)
LS mean
(2 sided 95% CIa)
| HbA1c (%) N
Baseline (mean± SD)
Change from baseline (mean ± SD)
|3277.04 ± 0.880.40 ±0.75
|3327.07 ± 0.760.14± 0.75
|0.25 (0.14,0.37)b
| Fasting Plasma Glucose (mg/dL) N
Baseline (mean± SD)
Change from base line mean ± SD)
|329146.8 ± 32.110.0± 40.8
|333145.6 ± 29.54.2 ± 35.9
|6.43 (0.57, 12.29)
| Plasma Insulin (µu/mL) N
Baseline (mean± SD)
Change from baseline base line (mean ± SD)
|304 17.9 ± 15.1 -3.6 ± 13.8
|31617.3 ± 10.5-3.2 ± 8.6
|0.02 (-1.47, 1.50)
| Body Weight (kg) N
Baseline (mean± SD)
Change from baseline (mean ± SD)
|31394.1 ± 17.80.3 ± 2.9
|320 93.3 ± 17.40.0 ±3.7
|0.08 (-0.22, 0.81)
| a CI= Confidence Interval
b FORTAMET® (metformin hcl) was clinically similar to immediate-release metformin based on the pre-defined criterion to establish efficacy. While demonstrating clinical similarity, the response to FORTAMET® (metformin hcl) compared to immediate-release metformin was also shown to be statistically smaller as seen by the 95% CI for the treatment difference which did not include zero.
Footnote: Patients were taking metformin-containing medications at baseline that were prescribed by their personal physician.
The mean changes for FPG (Table 3) and plasma insulin (Table 3) were small for both FORTAMET® (metformin hcl) and immediate-release metformin, and were not clinically meaningful. Seventy-six (22%) and 49 (14%) of the FORTAMET® (metformin hcl) and immediate-release patients, respectively, discontinued prematurely from the trial. Eighteen (5%) patients on FORTAMET® (metformin hcl) withdrew because of a stated lack of efficacy, as compared with 8 patients (2%) on immediate-release metformin (p=0.047). Results from this study also indicated that neither FORTAMET® (metformin hcl) nor immediate-release metformin were associated with weight gain or increases in body mass index. A 24-week, double blind, placebo-controlled study of immediate-release metformin plus insulin, versus insulin plus placebo, was conducted in patients with type 2 diabetes who failed to achieve adequate glycemic control on insulin alone(Table 4). Patients randomized to receive immediate-release metformin plus insulin achieved a reduction in HbA1c of 2.10%, compared to a 1.56% reduction in HbA1c achieved by insulin plus placebo. The improvement in glycemic control was achieved at the final study visit with 16% less insulin, 93.0 U/day versus 110.6 U/day, immediate-release metformin plus insulin versus insulin plus placebo, respectively, p=0.04.
Table 4: Combined Immediate-Release Metformin /Insulin vs. Placebo/Insulin: Summary of Mean Changes from Baseline in HbA1c and Daily Insulin Dose
| Placebo/Insulin
(n = 28)
| Treatment difference
Mean ± SE
| Immediate-Release
Metformin /Insulin
(n = 26)
| HbA1c (%)
Baseline 9.32
|Change at FINAL VISIT -1.56
|-0.54 ± 0.43a
| Insulin Dose (U/day)
Baseline 94.64
|Change at FINAL VISIT 15.93
|-16.08 ± 7.77b
| a Statistically significant using analysis of
covariance with baseline as covariate (p=0.04). Not significant using analysisof
variance (values shown in table)
b Statistically significant for insulin (p=0.04)
A second double-blind, placebo-controlled study (n=51), with 16 weeks of randomized treatment, demonstrated that in patients with type 2 diabetes controlled on insulin for 8 weeks with an average HbA1c of 7.46 ± 0.97%, the addition of immediate-release metformin maintained similar glycemic control (HbA1c 7.15 ± 0.61 versus 6.97 ± 0.62 for immediate-release metformin plus insulin and placebo plus insulin, respectively) with 19% less insulin versus baseline (reduction of 23.68 ± 30.22 versus an increase of 0.43 ± 25.20 units for immediate-release metformin plus insulin and placebo plus insulin, p < 0.01). In addition, this study demonstrated that the combination of immediate-release metformin plus insulin resulted in reduction in body weight of 3.11 ± 4.30 lbs, compared to an increase of 1.30 ± 6.08 lbs for placebo plus insulin, p=0.01.
Pediatric Clinical Studies
No pediatric clinical studies have been conducted with FORTAMET® (metformin hcl) . In a double-blind, placebo- controlled study in pediatric patients aged 10 to 16 years with type 2 diabetes (mean FPG 182.2 mg/dL), treatment with immediate-release metformin (up to 2000 mg/day) for up to 16 weeks (mean duration of treatment 11 weeks) resulted in a significant mean net reduction in FPG of 64.3 mg/dL compared with placebo (Table 5).
Table 5: Immediate-Release Metformin vs. Placebo (Pediatricsa): Summary of Mean Changes from Baseline* in Plasma Glucose and Body Weight at Final Visit
| Immediate-Release
|FPG (mg/dL)
|(n = 37)
|(n = 36)
|Change at FINAL VISIT
|< 0.001
|Body Weight (lbs)
|(n = 39)
|(n = 38)
|Change at FINAL VISIT
| a Pediatric patients mean age 13.8 years (range
10-16 years)
* All patients on diet therapy at Baseline
** Not statistically significant
Last reviewed on RxList: 9/25/2008
This monograph has been modified to include the generic and brand name in many instances.
Fortamet FDA Prescribing Information
Additional Fortamet Information
Fortamet - User Reviews
Fortamet User Reviews
Now you can gain knowledge and insight about a drug treatment with Patient Discussions.
Here is a collection of user reviews for the medication Fortamet sorted by most helpful.
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Women's Health
Find out what women really need.


text:
To the Editor:
The Holiday Bureau would like to thank Sharon Duncan of the Eastern Star No. 390 of Oak Ridge and Bobby Duncan of Faith Masonic Lodge No. 756 of Oak Ridge for the fundraiser they had at the Faith Masonic No. 756 in May.
Robert Anderson
Holiday Bureau volunteer
Location, ST | website.com

subset: commoncrawl


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On 12/5/2007 around 5:30 PM Topeka Police located Jermaine T Brown BM 1/20/89 at 711 SE 4th Street.
Brown was wanted in relation to an aggravated assault, criminal discharge of a firearm into an occupied vehicle, and criminal damage to property relating to a past shooting incident on December 4 near the area of Munson and Wayne.
Brown was taken to police headquarters where he was interviewed and then booked into the Shawnee County Department of Corrections on the charges above.
Police ask that anyone with information regarding this or any other crime to call Crime Stoppers 234-0007.


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January 2013, TruckingInfo.com - Feature
By Deborah Lockridge
Three years from now, you'll see a new API diesel engine oil-service category, designed to help meet federal greenhouse gas/fuel economy standards, which have a final phase-in date set for model year 2018 trucks.
Tags: Under The Hood, API, Oils, Chevron, Shell
We offer e-newsletters that deliver targeted news and information for the entire fleet industry.
The expert, Brian Fletcher from Eaton, will answer your questions
TomTom Partnership Adds Real-Time Accounting
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Reyco Granning DM400e is Lighter Than Predecessor
Baldwin Filters Offers Aftermarket Filter Designed for Kenworth Models


text: AdChoices Terms of Use Privacy Policy Hide TOP 10 Top 10 Entertainment Top 6: Canadians On The 2010 Top 99 Share Tweet 0 Shares 4. Coco Rocha Coco Rocha (née Mikhaila Rocha) began her professional modeling career in 2004, but this supermodel has blown up so fast and so big that it's hard to remember a time before we all knew this pretty girl with the kooky name. Rocha, who is an accomplished Irish dancer, was first discovered by agent Charles Stuart while at a dance competition in 2002. In 2006, a meeting with renowned photographer Steven Meisel sparked the beginning of her ascent in the fashion industry, starting with the cover of Italian Vogue in March of that year. Rocha leaped into the forefront of the industry when she Irish danced down the Paris runway in Jean Paul Gaultier's Fall 2007 show -- from that moment on, the world wanted more Coco. She's since appeared in campaigns for Dior, Chanel, Yves Saint-Laurent, Gap, Tommy Hilfiger, and the list goes on. With those high cheekbones and warrior brow, her look is very editorial -- she almost appears untouchable and otherworldly. Yet, through her video segments on Style.com, we see that she is instead a goofy, down-to-earth Canuck with whom we can connect -- just one more reason to love Coco Rocha. Next Page TOP 6 5 4 3 2 1 Comments Share your opinion Your name More Like This Top 10 Entertainment Top 10: Women We Expect To See In 2012's Top 99 Read More Top 10 Entertainment Top 10: Girls We Expect To See On Next Year's Top 99 Read More Top 10 Entertainment AM UK: Top British Top 99ers Read More Life Commentary Former Top 99 No. 1s Read More Top 10 Entertainment The Hottest Playboy Models Of The Year Read More Top 10 Entertainment The Top 10 "Hot" Girls Who Actually Aren't Hot Read More Around the Web Special Features Guy Gear The Best Watches Under $500 Read More Special Feature The Ultimate Guide To Hooking Up Online Read More


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|This is the talk page for discussing improvements to the Piano article.
This is not a forum for general discussion of the article's subject.
Article policies
|Archives: 1, 2, 3, 4
|Piano has been listed as a level-4 vital article in Art. If you can improve it, please do. This article has been rated as C-Class.
|Piano was a Music good articles nominee, but did not meet the good article criteria at the time. There are suggestions below for improving the article. Once these issues have been addressed, the article can be renominated. Editors may also seek a reassessment of the decision if they believe there was a mistake.
|This article is of interest to the following WikiProjects:
How to handle global "additional citations needed" tag and referencing for Piano?[edit]
There's currently an "additional citations needed" tag covering the entire article. Meanwhile, there are numerous inline citations, a Bibliography section, and a Notes section indicating several additional reference sources. Some sections are better sourced than others, and there are a few inline citation needed tags.
The problem with sourcing this article in particular is the amount of technical and historical detail it contains. Depending on how rigorous the approach, some sections would be overrun by inline citations added to practically every sentence. Also, likely there would be a fair number of instances of citing the same source multiple times.
There is guidance in Wikipedia:Citing sources. Some possible solutions that can be used in combination:
- Updating the Bibliography with notes per book indicating which areas of the article it covers.
- Marking sections with little or no sourcing with "citations needed" tag.
- Indicating all individual items that need citing with incline "citation needed" tags.
(My particular concern is with the global "citations needed" tag, which we can hopefully remove. Tags that cover entire articles may diminish the apparent value of the article, and in this case, it seems pretty clear that, overall, the article is verifiable via inline citations and bibliography.)
Ideas? Suggestions? --Tsavage (talk) 04:02, 18 February 2015 (UTC)
- Personally, I find umbrella "citations needed" tags on long article like this completely useless. Tagging specific statements needing citations is more helpful—even essential in this case. This is according to what your are citing from the "citing sources" guideline.
- In addition, I am totally confused here by that section marked "Notes". There are already "notes" as inline citations (let us call these "notes1"), and the content of this second section looks like "Further reading" to me (let us call these "notes2"). They are bibliography style entries, not annotations of particular statements in the article. On the other hand, I have not checked the "Bibliography" items to discover whether they are sources actually cited in the notes1, or indeed whether any of the items in notes2 are cited in notes1. I think you can see why this confuses me.—Jerome Kohl (talk) 05:39, 18 February 2015 (UTC)
- Thanks for the constructive input! :) I investigated further, and I believe progress has been made.
- This is the where the References section was originally established, and it explains what is now under Notes, i.e. that they are general references for the article.
- I created the Bibliography subhead to accommodate referring to different pages of the same book in different citations (and I left one book duplicated in Notes because it wasn't clear what Notes was). I guess that heading was unnecessary and redundant under References.
- Given that Notes is now general reference, it seems that Further reading may be just that (can ask original editor User:Opus33).
- I've adjusted the article accordingly as follows:
- removed Bibliography subhead (unnecessary in References section)
- renamed Notes section to General (General references) and restored the original note "Most of the information in this article can be found in the following published works:" (per [1])
- I restored Encyclopedia Britannica to the General list as it was there originally. (Does "most of the info..." still apply if it is deleted?)
UPDATE: Removed the umbrella "additional citations needed" tag from Jul 2013, per the above. The article has been significantly reorganized, citations and inline citations added, and the General references section clarfied. Considering the large number of individual details that could be individually cited, which would make the article difficult to read and many of the citations kind of redundant, the use of general references in addition to inline citations seems like a good idea. (Additional inline citation needed tags are probably still required.) --Tsavage (talk) 16:07, 7 March 2015 (UTC)
General references:: Encyclopedia Britannica removed[edit]
Removed Encyclopedia Britannica from the References > General section as a less than reliable source, and let stand the statement: "Most of the information in this article can be found in the following published works:" Considering that the four remaining works are described by the original editor as, respectively:
- "a standard reference on the history of the piano"
- "an authoritative work covering the ancestry of the piano, its invention by Cristofori, and the early stages of its subsequent evolution"
- "contains a wealth of information"
- "gives the basics of how pianos work, and a thorough evaluative survey of current pianos and their manufacturers"
it seems reasonable to assume that most of the information in the article can still be found in these remaining books listed under General references. --Tsavage (talk) 11:48, 20 February 2015 (UTC)
Semi-protected edit request on 23 March 2016: Pronunciation[edit]
|This edit request has been answered. Set the
|answered= or
|ans= parameter to no to reactivate your request.
Pronunciation is probably more clearly transcribed as /piˈænoʊ/; in accordance with the English Wiktionary entry. Netuser00 (talk) 03:41, 23 March 2016 (UTC)
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Northern California couple drive to New Orleans for Super BowlUPDATED 7:49 AM PST Feb 01, 2013
A local couple drove all the way from the Modesto area to New Orleans for the Super Bowl.
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This Week #PKDHMMPP - Pankuri Will Cry and aditya will console her,and Pankhuri decides to get Latika and Aditya together.so she will lie
#PKDHMMPP Aditya will curious to know about her boyfriend
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[edit] Background
In the not too distant future the streets are overrun with criminals. The URIEL consortium has bought the police department and given them 3 new vehicles to help in their fight against crime. All you have to do is keep the streets free of crime using your new toys. It may sound simple, but the challenges you will face in this game will test your nerves almost to breaking point. Only nerves of steel will see you through this game.
[edit] Features
- Patrol the streets at a breakneck speed of 60 frames per second.
- Bring in law-breakers dead or alive (or barely alive) with high-powered non-lethal or lethal weapons like the Vulcan Cannon.
- Maintain the peace with the Turbo Patrol Car, Bike or Wing - you're a crack shot with each.
- Real-time 3D environments with complete freedom of movement for clean shots in the back.
- Over 17 scenarios of adrenaline-pumping high-speed criminal pursuit missions - all caught on interior or exterior cameras.
- 1 or 2-player split-screen action.


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Hi Everyone....
DS will be 6 weeks on monday...I am doing good...taking great care of him - he's a wonderful baby - but I am EXHAUSTED!! how am I going to make it through this?
I am having a hard time "napping when the baby does" because the tenants below me scream all day long at the top of their lungs..no exageration (it's a sad situation...CPS has been over many times, including today)
DS and I are dealing with thrush and the pain is horrible. We have been following treatment for a week...but not much improvement.
I am doing this ALL alone and I do have help two nights a week but it isn't very restful because I always get the baby handed back to me when he is fussy (which is all night long) I am exclusively breastfeeding and so I have to get up after atleast 5 hours of sleep because I get so engorged.
I am working 2-3 days a week and that exhaustion is worse that how tired I get taking care of DS. I work as a stylist and double book my clients to fit everyone in and make enough to support us. I get no child support or contact from DS's father.
I am so lonely even though DS is the best company.
When will I feel better? I am determined to be a successful single mom...but am I capable? I've made it this far...but how long can I go like this?
Any input would be greatly appreciated...


text:
Questions & Answers
I have a PT who wants to apply for disability when she delivers her baby, she is pad cash does not have pay stubs, would she be able to apply?
I was on paid sick leave from May 2015 – January 2016. I returned to work in February 2016 and will be laid-off on July 17, 2016. Can I apply for unemployment? Does one have to work 5 continuous quarters prior to lay-off? I was consistently employed for 39 years prior to the medical leave in the state of California. Thank you.
I been living in California for a little bit more than a year already. I was working for a company for almost a year and I got let go because I missed on day and it was extremely busy that day and lot of people missed.
My hours are reduced to part time in marhc, then 1day each next two weeks. I planned for a vacation in two weeks which was approved over 6month ago. I cannot go look for a job now since I have to go off for 3 weeks which is to see my aging mother who I havent seen for two years. Can I apply for UI now or when I'm back? Thank you.
I had applied for unemployment back on March 4th 2016 it's been two weeks and I have not heard a thing. What can I do?
I tried to reopen my claim said I have duplicate submission what does that mean
I have been on state disability for the last 12 months… I am now released for work but my position is no longer available, Can I receive unemployment if I haven't worked the past year?
My company in so cal filed chapter 11, im veing furloughed 4 days a month , and am told i mught lose my 213 hrs vacation i accrued.ive been there 15 years, if i quit now befor chapter 7 or buy out so i can get my vacation can i still file for unemployment benifits
ive worked for this company for almost 2 yrs and someone bought us out we still have one restruant and I don't get the hours or salary like I did from the little restraunt can I applu for unemployment
the company I worked for 17 years told me I was no longer a employee but a sub-contractor and I worked for a while nothing changed expect no benefits can I draw unemployment benefits in the state of calif.
Has anyone file an Arizona weekly claim by the internet while being in california before? I Will be out of state for couple days and want to know if there could be issues if I do so, since I've had this experience before where I had to be out of the country for a weekend,(visiting the dentist) and thought there was no problem if i filed my claim while been out and oh surprise, i didn't received payment from that week and received a letter asking a bunch of questions, if I had move out the U.S and if I planned to come back, etc. Had to return it with my answers and finally my payments where delayed until that issue was solved.
If my benefit were delayed for 5 weeks for not filing 2 continued claim forms properly in a past claim. Q. will benefits for the claiming weeks while on suspension be awarded all at once. On completion of suspension.
Hi There:
I was working in Williston and I got lay of , now I'm leaving in los angeles . Can I applied for unemployment in los angeles ?
I used to live and work in the state of Arizona, got laid of and now I am living in California. Can I apply for unemployment in CA for the last trimester I work in AZ?
If i separate out the military can i file for unemployment?
I was trying to find out if I could collect unemployment after being laid off.I had workers comp injury 3 years. I have been cleared to return to work. I had 2 back surgery's now I am cleared, no restrictions.
Hello..I am collecting unemployment benefits in California since January 2014.It will run out this mid.September..Are there any federal extentions ?
I had to quit my job because I am not able to perform the job duties due to physical problems with my back and leg. I have been there 5 1/2 years. Can I qualify for unemployment? I was on temp disabilty but that has stopped due to my doctors not doing their work in a timely manner.
Thank you
Can a person on unemployment relocate to another state and look for another job and still collect california unemployment by putting in a change of address?
I have applied for UI benefits after relocating to MA from CA. How can I check my application status and why can't I talk with a human being?
Not all web sites are intuitive in finding what you need and clearly I'm missing the application status button. MA has a system where you login to your established account. Where is CA's?
I work in AZ but im a recident from CA. I pay taxes from CA and AZ, they told us that we have one more month of work and im going back to CA, can i get my unemployment from CA?
I am on partial unemployment in calif. because my co. reduced me from 40 hrs to very part-time hrs. My co. decided not to give me anjy hrs for 3 and one half weeks so I quite on april 24th 2014. What happens now, How do I notify unemployment that i quit and have them review my claim. You cannot get through on the phone Anymore. E-mail does not respond to this type of question.I have received money for the 2 weeks after I quit and it might be over-payment.
I'm in California. Original claim ran from 04/13 thru 04/14. Received 26 wks. tier 1 of extension, like all cut off end of 12/13. At one year of original filing received de429l invalid claim for 04/06/14 & received de429z notice of award with new claim year 04/14 thru 04/15 with award amounts and April & June quarters with my earning that where used. Info includes what forms will be arriving, weekly claim forms and info to register at cal jobs. Confused because both forms arrived within two days of each other. Is award notice valid? Can't reach anyone by phone at edd. Should I just wait to see if claim forms arrive or send in appeal form that came with de429l invalid claim?
Thanks for any info you can help with.
My company was just sold and I had to reapply and was not hired, I worked for the previous company for just about 2yrs, can I apply for EDD? Am I eligible? and how would I file?
Thank You.
Do I need to claim my Ca disability on my CA unemployment form .
I ve been laid off. I have worked for the company for 16 months which have paid into unemployment benefits. I have also worked off and on at another job which did not pay into benefits Does this change or disrupt in any way for filing or collecting benefits in ca.
If I know there gona lay me off and I have a release date can I file a claim before I'm lay off.
I quit my self employed job to take a seasonal waitress job in May 2013 through Oct 2013.
The calculator estimated I didn't make enough in qualifying period to receive benefits. It said contact a rep which I have tried for 2 weeks. Is there a way to use my income from July-Oct? Or should I wait until January to apply when there will be a bigger quarter? How can I talk to a person for help?
can I receive unemployment while going to college? Are there additional cash aid programs for unemployed moms attending school?
If I retire from one company and go to work for another company,
full time, it is a temporary job for 3-1/2 months, will I be able to file for unemployement after the new job is finished?
I am trying to find the year I last received unemployment . My Cell number is 951 880-8313. Or you can notify me by email. Thank you
I am following up on my Claim,
1st week (08/25)(08/31)
2nd week (09/01)(09/07)
I mailed it in (09/08/2013)I thought I would have seen something…Is it there?
Dale G. Ferguson
24011 Juaneno Dr Mission Viejo Dr. 92691
cell (949)326-8632
Are extensions still being offered? My regular UI benefits will run out on December 31. Given that companies typically stop hiring for full time employment the last 2 months of the year that realistically gives me only 2 1/2 months to find a job.
When I had my phone interview with the EDD representative last month I asked her how I would go about filing for an extension in the event I had not found a job yet and had exhausted my regular UI benefits. She told me that due to budget cuts they were not offering anymore extensions and that my only recourse would be to go to the county for assistance.
But, when I look at the info on the CA UI benefits on this site it says the maximum is 65 weeks which infers that there are extensions still being offered.
Can you please clear up my confusion?
I never received my packet in the mail . I filed a claim over the phone and no packet came in the mail! The representative said it would be here in 10 days! It is not! Tried to call 7/29 u were closed and tried first thing this morning to heavy calls coming in!
i recently quit my job to reloate to southern california from central california becausd spouse job is in so .cal we were having diffuculty paying 2 rents and managing to households can i collect unemployment til i find a job..
I do currently have a job but have a 6 month old that I'm unable to have an affordable babysitter. If I quit due to me having to take care of my baby could I collect some kind of unemployment?
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text:
What is the function of refresh in Windows ?
is it just to redraw the screen ?
What is the function of refresh in Windows ?
closed as not a real question by Ignacio Vazquez-Abrams, Hello71, Journeyman Geek♦, Wuffers, nhinkle♦ Jun 28 '11 at 3:18
It's difficult to tell what is being asked here. This question is ambiguous, vague, incomplete, overly broad, or rhetorical and cannot be reasonably answered in its current form. For help clarifying this question so that it can be reopened, visit the help center.If this question can be reworded to fit the rules in the help center, please edit the question.
The two most common cases:
The F5 key is most commonly used for this function. In most browsers, CTRL+F5 forces a full page reload, ignoring any cached files.
It can just redraw the screen, or it can reload a page, like in a browser...it depends on where you hit it. It is worth noting that with some web sites, you need to hit


text:
Monster Digital Daytona 240GB SSD Review
Desktop Test System
Lenovo W530 - Mobile Workstation
We use two systems for SSD testing. The desktop runs a majority of the tests and the Lenovo W530 runs the notebook power tests as well as the real-world file transfer benchmark.
ATTO Baseline Performance
Version and / or Patch Used: 2.34
ATTO is used by many disk manufacturers to determine the read and write speeds that will be presented to customers.
The performance in ATTO is quite good with Daytona 240GB nearly topping 560MB/s read and 535MB/s write throughput. The early benchmarks are not going to show the true behavior of this drive, though.
PRICING: You can find products similar to this one for sale below.
United States: Find other tech and computer products like this over at Amazon's website.
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Canada: Find other tech and computer products like this over at Amazon Canada's website.
- Page 1 [Introduction]
- Page 2 [Specifications, Pricing and Availability]
- Page 3 [Package]
- Page 4 [Monster Digital Daytona 240GB SSD]
- Page 5 [Benchmarks - Test System Setup and ATTO Baseline Performance]
- Page 6 [Benchmarks - Sequential Performance]
- Page 7 [Benchmarks - AIDA64 Random Access Time]
- Page 8 [Benchmarks - Anvil Storage Utilities]
- Page 9 [Benchmarks - CrystalDiskMark]
- Page 10 [Benchmarks - PCMark Vantage Hard Disk Tests]
- Page 11 [Benchmarks - PCMark Vantage - Drives with Data Testing]
- Page 12 [Benchmarks - BootRacer]
- Page 13 [Benchmarks - DiskBench]
- Page 14 [Benchmarks - Power Testing]
- Page 15 [Final Thoughts]
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text:
The authors report a clinical experiment conducted over a course of six years presenting evidence that favors the small, but not too small, stoma, and shows that better results are thereby accomplished. We therefore do not need to use the Billroth I operation.
The Billroth II type of gastric resection has been largely accepted by surgeons for its ability to prevent peptic ulcer recurrence if definitive operation is required. The recurrence rate is the lowest for all procedures, and the mortality and immediate morbidity rates are comparable. However, the late postgastrectomy findings of weight loss, diarrhea, and the dumping syndrome with accompanying weakness are believed to be more numerous than those with other procedures, notably gastroenterostomy and the Billroth I procedure. These disagreeable sequelae have urged surgeons to find a better operative procedure.1-12 It is apparent that if the postgastrectomy symptoms could be prevented or materially lessened, then the
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Redirected from Road Train
this wiki
The Roadtrain is a semi-trailer truck in Grand Theft Auto: San Andreas.
The Roadtrain is designed as a large rugged semi-truck, being the largest, heaviest and most powerful among the game's three semi trucks (the other two being the Tanker and Linerunner), and comes complete with a large frontal bullbar, a bug catcher over the radiator grille, and twin stoke pipe air intakes. The truck is further distinguished by its two-tone body color.
The design of the truck itself is presumably based on heavy duty "prime movers" tractor units in Australia, which tend to be used to haul road trains (consisting of two or more articulated trailers) to remote parts of the country. Australian prime mover models such as the Macks (Black Thunder, Titan), and Western Stars may be sources of inspiration for the Roadtrain.
The truck's performance is impressive, possessing a relatively high top speed (especially in straightaways and downhill travel), as well as excellent torque for improved hill climbing and acceleration, and responsive steering and brakes. The vehicle's weight distribution, wide length and width makes the Roadtrain more stable than the Tanker or Linerunner, although high speed encounters with bumps may still flip the vehicle. The vehicle's heavy construction also makes the Roadtrain very durable.
Image Gallery
- Spawns regularly around the desert and countryside of San Andreas.
- Found near the freight dock at Easter Basin, San Fierro.
- Found in the Angel Pine Sawmill at Angel Pine, Whetstone.
- Very rarely seen in Red County.
- The default radio station of the Roadtrain is K-Rose.
- On the original PS2 version of GTA San Andreas, the Roadtrain had double rear wheels, however when the player skids or does burnouts with the vehicle, it will only leave single tire skid marks.
- On subsequent releases of the game on PC and Xbox, the Roadtrain has been modified so it only has single rear wheels.
- In the beta, there was going to be a green 'artict3' styled trailer intended to be pulled by the Roadtrain. This unused trailer can be found in the game files, and it can be spawned with mods. However, using modifications to make it usable won't work as the trailer itself can't be attached to any truck.
See Also
- Juggernaut - Grand Theft Auto 1 equivalent.
- Truck Cab and Truck Cab SX - Grand Theft Auto 2 equivalents.
- Linerunner - 3D Universe equivalent.
- Tanker - Grand Theft Auto: San Andreas equivalent.
- Phantom - Grand Theft Auto IV and Grand Theft Auto V equivalent.


text:
Schizophrenia and Aging
NPR's Wendy Schmelzer reports on the relationship between schizophrenia and aging. Researchers are paying particular attention to "late onset schizophrenia," which occurs after age 45. But they also are studying how the aging process affects people who develop the disease earlier in life. Healthcare providers are concerned about how to provide adequate medical attention to people with schizophrenia, as the overall population ages.
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Please keep your community civil. All comments must follow the NPR.org Community rules and terms of use, and will be moderated prior to posting. NPR reserves the right to use the comments we receive, in whole or in part, and to use the commenter's name and location, in any medium. See also the Terms of Use, Privacy Policy and Community FAQ.


text:
Top Photoshop Commercial Ad Mistakes.
Sometimes when you hire crappy Photoshop artist or just to lazy to double check their work, you end up with the funniest Masterpieces published live for the world to see. Here is a small sample of such mistakes:
See I knew all them high priced designers were good for something.. A laugh is worth more than you think


text:
|Boxing Champions | Boxing Schedule | Boxing Video | Boxing History | Pound For Pound | Lounge | The Wire | Arcade
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i must admitt the more i watch 24-7 the more i think pacman is gonna kick oscars ass
not counting oscar out...but the more i watch it..oscar looks terrible in sparring..and pacman is looking like a beast(but they could be showing those clips just to sell the fight)what do ya'll think
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I think Pacs team is too fat
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Editing is a wonderful thing. Remember the PBF vs Hatton 24/7 the way it was editited people really thought Hatton had a chance but we all saw what happened on fight night.
F^CK De la Hoya vs. Pacman!!!!!!!!!!!!!!!!!!!!!!
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Staying on topic, I think Pacman has a really good chance at beating DLH - not so much because of 24/7 though.... all of that is golden boy propaganda. He might even stop him on cuts or stop him on his feet from so many punches. The key is going to be how many punches Manny can land on DLH while avoiding all (or most) or DLH's firepower.
That Admin Money
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im still not sure on this one...
oscar could be too old... and pacman could be to mobile for oscar to deal with it 3 full mins for 12 full rounds...
or oscar might be on point, and jjust too big and strong for pacman...
itll either be oscar KO or pacman UD... its got me interested
Wrapidad was garbage
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I must admit that after the 24/7 on mayweather / hatton i thought that hatton had a great chance at winning.
No Ceilings
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the only time we've seen Oscar in trouble or getting the better of was at 160 w/ hopkins and sturm..... so no i dont see pacman kickin oscars ass
milking the cashcow
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My heart says Pacquiao but my mind tells me its Oscar... and my nose is bleeding right now
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i dont know if he has a chance but surely oscar looks nervous and insecure while Pac looks sure of himself and ready to fight. Oscar calling 2 trainers and even Bernard to give some pointers is kinda strange.
Funny when BHop was telling that sparring partner instructions 'do like that with flurries from low to high, mimic pacman, do what he do, make him work''...looked like that guy was being too respectful for Oscar. But that may be only the right editing to make it look competitive so i dont know.
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text:
Water, Air, and Soil Pollution
, Volume 85, Issue 3, pp 1089-1094
First online:
The seasonal variation in soil water acid neutralizing capacity in peaty podzols in Mid-Wales
- P. J. ChapmanAffiliated withDepartment of Civil Engineering, Imperial College
- , B. ReynoldsAffiliated withInstitute of Terrestrial Ecology, Bangor Research Unit
- , H. S. WheaterAffiliated withDepartment of Civil Engineering, Imperial College
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Between 1985 and 1990, bulk precipitation and soil solution from the organic (Oh) and mineral (Bs) horizons of a well developed podzol were regularly sampled at a moorland catchment in Mid-Wales. Samples were analysed for pH, major cations, major anions, and dissolved organic carbon (DOC). Acid neutralizing capacity (ANC) was estimated by the charge balance method. Average monthly ANC of soil solutions from the Oh horizon varied seasonally, with a maximum in July and a minimum in February. In contrast, H+ concentrations varied little. Solute deposition, dominated by sodium and chloride, also varied seasonally with a winter maximum, which is reflected in the soil solution chemical composition. In the Oh horizon during winter, the increase in base cation (Na) concentrations led to release of H+ through ion exchange. ANC declined in the absence of any buffering mechanism. In summer, the depletion of exchangeable acidity that occurred in winter, was replenished by H+ produced by the dissociation of organic acids. During this period, organic anions contribute to an increase in ANC, while H+ concentrations remained similar to those in winter. These processes probably influenced the acidity and ANC of Bs horizon soil solutions but to a lesser extent than in the Oh horizon. Other mechanisms such as weathering and ion exchange involving H+ and Al may buffer solution acidity in the mineral soil.
Key wordssoil solution acid neutralizing capacity acidity ion exchange organic acids cations anions
Reference tools
- Title
- The seasonal variation in soil water acid neutralizing capacity in peaty podzols in Mid-Wales
- Journal
Water, Air, and Soil Pollution
Volume 85, Issue 3 , pp 1089-1094
- Cover Date
- 1995-12
- Print ISSN
- 0049-6979
- Online ISSN
- 1573-2932
- Publisher
- Kluwer Academic Publishers
- Additional Links
- Topics
- Keywords
- soil solution
- acid neutralizing capacity
- acidity
- ion exchange
- organic acids
- cations
- anions
- Industry Sectors
- Authors
- P. J. Chapman (1)
- B. Reynolds (2)
- H. S. Wheater (1)
- Author Affiliations
- 1. Department of Civil Engineering, Imperial College, SW7 2BU, London, UK
- 2. Institute of Terrestrial Ecology, Bangor Research Unit, Deiniol Road, LL57 2UP, Bangor, Gwynedd, UK


text:
Video Industry News Video Company News Technology Industry News Technology Company News Novelty Industry News Novelty Company News Gay Industry News Gay Company News Legal Industry News All Company News
Released: Sep 01st, 2005
Running Time: 74
Directors: John T, John T.
Company: Caballero
Cast: Samantha Strong, Amber Lynn, John Leslie, Greg Derek, Jesse Eastern, Steve Drake, Dana Dylan
Critical Rating: AAA 1/2
Genre: Golden Age
One of Samantha Strong\'s best, and sure to be a hot renter.
Samantha Strong does an excellent job here as the young virgin who'll inherit the titular sum if she stays that way until her 21st birthday - and hotties like Sharon Mitchell and Dana Dylan do almost as well as the avaricious aunt and maid, respectively, who try to make sure that doesn't happen. Strong's only protector is gal-pal Amber Lynn, looking spectacular here, who's supposed to watch out for Samantha on her pre-birthday slumber, but after a decent girl/girler with the busty blonde, winds up in a hot threeway with Steve Drake and Greg Derek.
Sadly, almost every scene is intercut with another, diminishing the heat of each, but there's enough hot action here to overcome that - especially the two final scenes, where first Drake has his way with a drugged Samantha, and later, both Greg and John Leslie do the same. However, both of those scenes are intercut with a stunt-cocked "anal" scene between Dana and Jesse Eastern - a definite flaw.


text:
"Macedonia" Republic of Macedonia by a5floor
Republic of Macedonia Travel Guide: 3,283 reviews and 12,046 photos
In the past, Macedonia was a provence/state of Yugoslavia. In the 1990s, when the war in Yugoslavia ended, the whole Yugslavia fell apart. So, Macedonia became a nation since then.
Here are some facts and figures about Macedonia:
Indepence from Yugoslavia since 8 September 1991.
Some people would say Republic of Macedonia, others say Former Yugoslav Republic of Macedonia (FYROM).
The population is about 2.2 million.
The capitol is Skopje.
Macedonia has 5 'neighbours': Albania, Kosovo, Serbia, Bulgaria and Greece.
There are 2 major lakes: Lake Ohrid (together with Albania) and Lake Prespa (together with Albania and Greece).
There are 2 airports in Macedonia. Alexander the Great airport in Skopje and St Paul the Apostle airport in Ohrid.
The 3 main religions are Orthodox Christian, Muslim and Jew.
The currency is the Macedonian Denar (MKD). The exchange rate is 1 Euro = 61 MKD (May/June 2011). In hotels you can pay either in Euros or Denars.
There are foreign ambassies and consulates in Macedonia. Embassies are from: Albania, Austra, Bosnia & Herzegovina, Bulgaria, China, Croatia, France, Germany, Greece, Hungary, Italy, the Netherlands, Norway, Poland, Romania, Russia, Serbia, Slovenia, Spain, Sweden, Switzerland, Turkey, Ukraine, UK and US. Consulates are from: Australia, Belgium, Bulgaria, Canada, Croatia, Denmark, Greece, Israel, Japan, Romania, Slovakia, Slovenia, Spain, Turkey and UK.
There are minorities in Macedonia: Albanians, Turks, Torbesi, Roma and Aromanians/Vlachs.
The people of Macedonia don't earn much money. About 300-400 Euro a month. For us Western Europeans/Americans/Canadians/Australian/New Zealand the cost for food, restaurants, hotels, etc in Macedonia are pretty cheap.
- Pros:I really liked Ohrid, Bitola and the landscape during the Euromeet & wine and dine tour. Awesome!!
- Cons:The capital Skopje
- In a nutshell:One of the countries you should have visited in your life.
Reviews (2)
The language from Macedonia doesn't make any sense to other people from the West. But when you are in Macedonia, try at... more travel advice
When you arrive in Macedonia by plane, this sign will be there in the arrival hall. Welcome to Macedonia! more travel advice
Comments (1)
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I have a website with many news. Lots of them have good Facebook Likes numbers (up to 100 likes for some articles and galleries)
After moving wordpress form "/news" to "/" (root), and doing an htaccess 301 rewrite redirect : all the facebook likes are at 0 !! (except the new artciles I am adding to the site)
After 4 hours... I have done many search on the web. I have done many tryal-errors in the code lines... just can't seem to get a code that will tell Facebook to use my old url
MY OLD CODE LINE that was working before is move
<iframe src="http://www.facebook.com/plugins/like.php?href=<?php echo urlencode(get_permalink($post->ID)); ?>&layout=button_count&show_faces=false&width=100&action=like&colorscheme=light" scrolling="no" frameborder="0" allowTransparency="true" style="border:none; overflow:hidden; width:100px; height:25px;">
MY NEW CODE LINE, working, but not as I want to
<div class="fb-like" data-href="<?php echo get_permalink(); ?>" data-width="100" data-layout="button_count" data-show-faces="false" data-send="false">

...remember that "/news" is the old location
?? IN PHP, HOW TO tell my wordpress code line to show exactly http://www.mysite.com/news/post-title
I have try many variation like these, but their results are not working okay
http://www.mysite.com/news/<?php echo urlencode(($post->ID)); ?>
<?php echo urlencode(get_permalink('/news/')($post->ID)); ?>


text:
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Philadelphia Flyers goalie IIya Bryzgalov stands in the goal crease during the national anthem before Game 1 of an opening-round NHL hockey playoff series against the Pittsburgh Penguins on Wednesday, April 11, 2012 in Pittsburgh. The Flyers won 4-3 in overtime. (AP Photo/Gene J. Puskar)
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Synonyms of dilute in English:
1 strong bleach can be diluted with water
make weaker, weaken;
thin out, thin, make thinner, water down, add water to;
mix, doctor, lace, adulterate
informal cut
[Antonyms] concentrate
adjectiveBack to top
the metal is etched with a dilute acid
weak, diluted, thin, thinned out, watered down, watery;
informal cut
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Don't miss LeAnn Rimes on "The Ellen Degeneres Show" today (check local listings for times). Keith Urban will perform his current single, "You'll Think Of Me," on NBC's "The Tonight Show with Jay Leno" tomorrow, plus he'll perform the song on "The Sharon Osbourne Show" for an episode scheduled to air on March 12. And this Friday (Jan. 30), Dierks Bentley will be the "celebrity courtyard correspondent" for "On-Air With Ryan Seacrest" (for information on channels and show times, go to ryanonair.com. )
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I'm hoping someone can help me on this. In Chrome, the "Older Entries" and "Newer Entries" links don't line up with their box. I'm not sure how long they've been like this... I just noticed it today.
In Internet Explorer they look fine. Not sure how they look in Safari or Firefox. What might be causing this?
Here's a page with the links:
Scroll all the way to the bottom. You have to look at it in Chrome to see what I mean. Thanks for any advice!


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|Um - living rurally in the winter - what do you do with your time?
We're remote ECing, unschooling, free ranging goat dairy farmers.
Ak Hippie mama Yamia DSD '03 DS '07 DS2 '09 & DS3 '12
We're remote ECing, unschooling, free ranging goat dairy farmers.
Jess mom to 5!!! 3 boys 2 girls and another girl on the way edd jan 31st! I have a Disabled veteran husband
breastfeeding,cosleeping, non vax,no circ,and nature loving family!
Subbing 'cause we are looking to move from our self-sufficient lifestyle here to AK also.
I'm wondering about COL though. Even as close to the land as we are here we still have property taxes etc, what (besides trapping) are the options for the income still needed? For bush life I know planes are sometimes the only way to get stuff in but how do people living primarily off the land afford that?
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Recent Appearances
MF Global and Peregrine Financial Bankruptcies, Regulators Panel
Witnesses testified on at the bankruptcy of MF Global. The panel also reviewed the recent collapse of Peregrine…
U.S. Economy and Wall Street
Special Master for Executive Compensation Kenneth Feinberg, and former SEC Chairman Harvey Pitts talked about the economy,…
MF Global Bankruptcy Investigation
Witnesses testified on the implications of and lessons learned from the collapse of MF Global. Topics included the…
MF Global Bankruptcy Investigation, Panel 3
Witnesses testified about the bankruptcy of the financial firm MF Global.


text:
The woodpeckers have a mostly cosmopolitan distribution, although they are absent from Australasia, Madagascar and Antarctica. They are also absent from the world's oceanic islands, although many insular species are found on continental islands. The true woodpeckers, subfamily Picinae, are distributed across the entire range of the woodpeckers. The Picumninae piculets have a pantropical distribution, with species in Southeast Asia, Africa and the Neotropics, with South America holding the majority of piculet species. The second piculet subfamily, Nesoctitinae, has a single species, the Antillean Piculet, which is restricted to the Caribbean island of Hispaniola. The wrynecks (Jynginae) have an exclusively Old World distribution, with the two species occurring in Europe, Asia and Africa.
Overall the woodpeckers are arboreal birds of wooded habitats. They reach their greatest diversity in tropical rainforests, but occur in almost all suitable habitats including woodlands, savannahs, scrublands, bamboo forests. Even grasslands and deserts have been colonised by various species. These habitats are more easily occupied where a small number of trees exist, or, in the case of desert species like the Gila Woodpecker, tall cacti are available for nesting in. A number of species are adapted to spending a portion of their time feeding on the ground, and a very small minority of species have abandoned trees entirely and nest in holes in the ground. The Ground Woodpecker is one such species, inhabiting the rocky and grassy hills of South Africa.
Picidae species can either be sedentary or migratory. Many species are known to stay in the same area year-round while others travel great distances from their breeding grounds to their wintering grounds. For example, the Eurasian Wryneck breeds in Europe and west Asia and migrates to the Sahel in Africa in the winter.
The woodpeckers range from highly antisocial solitary species which are aggressive to other members of their species to group living species. Group living species tend to be communal group breeders. In addition to these species a number of species may join mixed-species feeding flocks with other insectivorous birds, although they tend to stay at the edges of these groups. Joining these flocks allows woodpeckers to decrease anti-predator vigilance and increase their feeding rate.[8] Woodpeckers are diurnal, roosting at night inside holes. In most species the roost will become the nest during the breeding season.
Diet and feeding
The diet of woodpeckers consists mainly of insects and their grubs, and other arthropods, along with fruit, nuts and sap. The family is noted for its ability to acquire wood-boring grubs using their bills for hammering, but overall the family is characterised by its dietary flexibility, with many species being both highly omnivorous and opportunistic. The insect prey most commonly taken are insects found inside rotten wood and in crevices in bark on trees. These include beetles and their grubs, ants, termites, spiders,and caterpillars. These may be obtained either by gleaning or more famously by excavating wood. Having hammered a hole into the wood the prey is excavated by a long barbed tongue. The ability to excavate allows woodpeckers to obtain tree sap, an important source of food for some species. Most famously the sapsuckers, (genus Sphyrapicus ) feed in this fashion, but the technique is not restricted to these and others such as the Acorn Woodpecker also feed in this way. It was once thought that the technique was restricted to the New World, but Old World species such as the Arabian Woodpecker and Great Spotted Woodpecker also feed in this way.
All members of the family Picidae nest in cavities. Almost every species nests in tree cavities, although in deserts some species nest inside holes in cactus and a few species nest in holes dug into the earth. Woodpeckers and piculets will excavate their own nests, but wrynecks will not. The excavated nest is usually only lined from the wood chips produced as the hole was made. Many species of woodpeckers excavate one hole per breeding season, sometimes after multiple attempts. It takes around a month to finish the job. Abandoned holes are used by many other birds and mammals which are secondary cavity nesters.
Members of Picidae are typically monogamous, with a few species breeding cooperatively and some polygamy reported in a few species. Polyandry, where a female raises two broods with two separate males, has also been reported in the West Indian Woodpecker. A pair will work together to help build the nest, incubate the eggs and raise their altricial young. However, in most species the male does most of the nest excavation and takes the night shift while incubating the eggs. A nest will usually consist of 2-5 round white eggs. Since these birds are cavity nesters, their eggs do not need to be camouflaged and the white color helps the parents to see them in dim light. The eggs are incubated for about 11–14 days before the chicks are born. It takes about 18–30 days before the young are ready to leave the nest.
The phylogeny has been updated according to new knowledge about convergence patterns and evolutionary history. Most notably, the relationship of the picine genera has been largely clarified, and it was determined that the Antillean Piculet is a surviving offshoot of proto-woodpeckers.
The evolutionary history of this group is not well documented, but the known fossils allow some preliminary conclusions: the earliest known modern picids were piculet-like forms of the Late Oligocene, about 25 million years ago (mya). By that time, however, the group was already present in the Americas and Europe, and it is hypothesized that they actually evolved much earlier, maybe as early as the Early Eocene (50 mya). The modern subfamilies appear to be rather young by comparison; until the mid-Miocene (10-15 mya), all picids seem to have been small or mid-sized birds similar to a mixture between a piculet and a wryneck. On the other hand, there exists a feather enclosed in fossil amber from the Dominican Republic, dated to about 25 mya, which seems to indicate that the Nesoctitinae were already a distinct lineage by then.
Prehistoric representatives of the extant Picidae genera are treated in the genus articles. An enigmatic form based on a coracoid found in Pliocene deposits of New Providence, Bahamas, has been described as Bathoceleus hyphalus and probably also is a woodpecker.


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Looking for some spooky (but not scary) fun for Halloween? The kids Halloween shows on these fun Halloween DVDs would be perfect for your little ones. Here's a few of our yearly favorites plus a few new ones we've been watching this year.
This shop and my Descendants DIY jars has been compensated by Collective Bias, Inc. and its advertiser. All opinions and love for villains are mine alone. #Disney #VillainDescendants #CollectiveBias
I've always had a little bit of a soft side when it comes to Disney Villains. Is it a matter of choice, or are they a product of their circumstances? I mean, it's hard to hear the backstory of Maleficent and not feel at least a smidge of sympathy for her.
When I started to see commercials for Disney's Descendants I knew I wanted to watch the premiere on The Disney Channel. Fortunately my little Disney "mini me" Bubbles was happy to oblige and we sat down to watch it together. I wasn't disappointed – it was great! Continue reading »
We have a new tablet that Bubbles is very excited about. We spend a little time snuggling at night and she gets to use it with me, to play a few educational games, maybe watch a couple of videos. And once I showed her that we could use it to read some of her favorite books, she was thrilled.
For over a year now we've been accessing great Disney books through Disney Story Central's app on my iPhone. It's been great to have for on-the-go entertainment, but being able to let her read and listen on a bigger, brighter screen has been a treat for her. And watching her learn to read more words is a treat for me. Continue reading »
Pinterest is, even after all these years, still probably one of my favorite websites. There are tons of great DIY ideas, tantalizing recipes, and just plain pretty stuff. There are enough projects there to keep me busy for probably the rest of my life.
While I usually have the intent of making each recipe or completing each project that I pin, I do keep one board of pins that are for more immediate inspiration. Things I know, for sure, that I want to try – whenever I get some elusive "free time". This kids DIY hair accessory organizer is one of those things. Continue reading »
I received these Disney music CDs in order to facilitate my post. All words and opinions are my own.
One of the things I love most about Disney movies is the music that accompanies them. It always plays such an integral role in the storytelling. Which is why Disney soundtracks and other Disney music CDs make up a good portion of my music library.
Recently I received an awesome mix of Disney music CDs that made the entire family happy. Bubbles was thrilled with the Frozen and Disney Junior CDs, hubby immediately snagged the Guardians of the Galaxy Awesome Mix Vol. 1 (which I also love), and I was excited to get Into the Woods. Continue reading »


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WASHINGTON (AL.com)— All the buzz at the National Governors Association meeting over legalizing pot, some say, is just smoke.
Nearly three months after Colorado began selling recreational marijuana, the nation's governors are taking a cautious approach to loosening their drug laws despite growing support for legalization.
For more on this story, visit: http://blog.al.com/wire/2014/02/governors_legalized_pot_buzz_j.html#incart_river


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BBB Accredited Business since
Northern Repairs, Inc.Additional Locations
Phone: (248) 548-9666 Fax: (248) 547-5224 View Additional Phone Numbers 27201 Woodward Avenue, Berkley, MI 48072 http://www.northernautorepairs.com
BBB Business Reviews may not be reproduced for sales or promotional purposes.
Northern Auto is a family owned car repair shop. 40 years in the same location. Highest rating for honesty, competence, reasonable prices & timely work from our clients from NPR Radio's Car Talk unsolicited survey. Proudly serving Royal Oak-Berkley area since 1970. Northern is servicing domestic cars - GM, FORD, Chrysler and imports/foreign cars - KIA, HYundai, Toyota, Honda, Nissan, Subaru, VW, Volvo, Infiniti, Lexus and more. For you convenience After Hour Drop Off Box. Kids friendly waiting area. Loaner car $12.50 while yours is being repair. ASE (Michigan State) certified technicians. Properly insured and licensed repair facility. Angie's List Super Service Awarded shop 2009 and 2010. The SE Oakland County 2010 winner Vote4TheBest Detroit business by WDIV channel 4,
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Auto Air Conditioning Lubricating Service - Automotive Brake Service Auto Services Auto Repairing - Foreign Auto Diagnostic Service
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Northern Repairs, Inc. offers the following product(s): Winners, WDIV "Vote4theBest" Top 3 - 2015


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Joined on May 16, 2012
|Total: 9, showing: 1 – 9
Leica is now in the business of selling red dot logos?
Perfect camera. I'd buy one for $330.
Leica camera bodies, mechanics and lenses are made in Vila Nova de Famalicão by Leica Portugal. Then they are expedited to Germany where the electronics from Japan are added, as well as the Leica logo and "Made in Germany"...
Makes sense. No logo, higher price. With logo you get a discount for going around showing off and advertise the brand. Unless you are a superstar, then they even pay you to carry it around. Now tell that to Mercedes, they just keep growing and growing its front logo with each new model. Just saying "look here you morons, this is a mercedes!". And there's people who pay for that...
Leica does not compete with Canon or Nikon or Sony. They are in a different market -- luxury items. Their competitors are more like a trip around the world or a luxury watch or a really expensive champagne. Or a Porsche. Just like a owner of a Ferrari probably does not use more than 10% of its power, if at all, the same for Leica cameras. So what? If there's people buying them, it's their problem.
Atomez: Well, well, well... Leica cameras, lenses and other stuff are 90% Made In Portugal. Not Germany. Including this new overworked aluminum unibody Leica T.
Look here, the video is portuguese spoken but you'll get it.
Or google translate this:
"New Leica T represents over 1.5 million for Famalicão plant"
In Germany it's legal to label "Made in Germany" if at least 10% of the value added is of German origin. As they say in de video, cameras are sent to Germany where the imaging sensor is incorporated (probably made in Japan)
Well, well, well... Leica cameras, lenses and other stuff are 90% Made In Portugal. Not Germany. Including this new overworked aluminum unibody Leica T.
Look here, the video is portuguese spoken but you'll get it.
Or google translate this:
"New Leica T represents over 1.5 million for Famalicão plant"
iPhone 5 purple lens flare against a bright light source. Looks like a reflection on the lens.
Jonathan Siegel: If these cameras were made entirely by a cheap labour factory in some rural village, then I would take issue with their pricing and simply tag their wealthy consumers as sheep. If in fact these are all hand made in Germany as these photos imply, and the video that has been circulating showing how they refine each piece and paint the numbers on the lens by hand, then these cameras are absolutely worth the money. In my line of work, you might come after me and say the same thing, but if you sat there and watched just how long it takes me to do it, and the sheer amount of time, perfection and technique I pour into each project, you would understand my pricing as well. Besides, if these things were cheap then everyone would have one and it would lose it's magic. Work hard, save up, buy one when you are ready. That is what I intend to do.
Well, Leica cameras are actually 90% hand made in a rural village called Famalicão in the north of Portugal... Then they are shipped to Germany to get the "Made in Germany" logo.
Check here if you care to -- http://www.jornaldenegocios.pt/home.php?template=SHOWNEWS_V2&id=543817
It's in Portuguese but the video is self explanatory.
|Total: 9, showing: 1 – 9
|Chicago Alley by tko
from Down the alleyway
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from What Child's Dream May Come
|Widget by Wilfried HKG
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|Oxbow Bend by stickpointed
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text:
DENISON, TX - The cooler weather is a reminder the holidays are fast approaching. But before you prepare those holiday meals. The Grayson County Health Department has some tips about how to safely prepare your thanksgiving feast for your family.
The holidays are supposed to be a time of celebration spent with friends and family, not spent running back and forth to the bathroom. Amanda Ortez with the Grayson County Health Department says it only takes a few simple cooking precautions to avoid getting sick over the holidays.
"First and foremost is to wash you hands of course and wash them often especially between handling raw meats and other ready to eat foods."
And don't thaw the thanksgiving turkey at room temperature.
"The proper way to thaw your turkey," Ortez said, "is at refrigerated temperatures which is 41 or below."
Ortez says it's actually pretty easy to avoid food born illness over the holidays, you just have to make sure that whatever surface your cooking on you clean as well.
"Sanitize surface between raw meats and of course things such as produce, lettuce and things that are not going to be cooked prior to consuming," Ortez said.
The most common mistake families make is leaving the food out for people to graze on after the meal is over.
"Don't allow foods to remain in the danger zone, basically room temperature, for more than two hours," Ortez said. "And if it's more than four hours you need to immediately discard the items that have been out."
Following these simple tips could mean the difference between a memorable happy holiday and a miserable experience you'd rather forget.
"You don't want to send them home with an illness based upon the fact that you could have used a few simple steps to avoid food born illnesses," said Ortez.
For more tips on holiday food safety you can log on to www.cdc.gov/features/turkeytime


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WASHINGTON - Within the space of a few days this month, the Supreme Court will hear major cases challenging the death penalty, White House secrecy and the Bush administration's treatment of terrorism suspects.
The justices finish hearing cases for the term in late April and then begin the work of cranking out dozens of rulings before the session ends in late June.
The court already has heard 67 cases and decided 45 of them, a pace about equal to those of recent years. There are 12 cases yet to be heard.
"The best is yet to come," Washington lawyer Thomas Goldstein, a Supreme Court specialist. "The court will hear blockbuster case after blockbuster case. Virtually every day there is front-page news."
The capital murder case being argued April 19 could overturn the death sentences of about 100 inmates in several states.
What's left
Elk Grove Unified School District v. Newdow, 02-1624: a constitutional challenge to the words "under God" in the Pledge of Allegiance as it is recited in public schools.
Cheney v. U.S. District Court, 03-475: the Bush administration's appeal in a case about closed-door sessions to develop a White House energy policy.
Rasul v. Bush, 03-334, and Al Odah v. United States, 03-343: involve foreign-born captives held at the military prison for terrorism suspects at Guantanamo Bay, Cuba.
Hamdi v. Rumsfeld, 03-6696: a challenge to the open-ended military detention of a terrorism suspect born in the United States but captured overseas.
Rumsfeld v. Padilla, 03-1027: a similar case involving a U.S.-born terror suspect captured on American soil.
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