text:
Building Stratford-upon-Manhattan
Michael Boyd, the artistic director of the Royal Shakespeare Company, has arrived in New York—and he's brought a bit of Stratford-upon-Avon with him.
This summer, in tandem with the Lincoln Center Festival and the Park Avenue Armory, the RSC is staging five plays in repertory —complete with a full-scale replica of its Stratford theater—starting with "As You Like It" on Wednesday evening, and continuing with "Julius Caesar," "King Lear," "Romeo and Juliet" and "The Winter's Tale."
The Journal caught up with Mr. Boyd to talk about why he chose to rebuild his theater, New Yorkers' appetite for Shakespeare, and what he looks forward to doing in the city.
Your company of actors has been performing these five plays for three years. What was the origin of this repertoire?
It sort of grew organically between the good parts for the actors, good plays for the directors, good plays we hadn't just done the year before or were about to do, and purely by accident we came up with what turned out to be a complete history of Shakespeare. So, you see this young, funny, obscene, angry playwright in "Romeo and Juliet," and you see this man who is genuinely facing mortality in " King Lear." It's very beautiful to follow him in his life and through the growth of his art.
Why do this event in New York?
New York, together with London and Moscow, are probably the three most important theatrical capitals in the world. It feels very natural and very exciting to come here, to compare our work with the best in the world. It sounds like flattery but New York audiences genuinely do bring the perfect marriage of sophistication and generosity of spirit.
Why do you prefer to use a thrust stage surrounded by the audience?
I love it because it has the sculptural, three-dimensional excitement that Hollywood can only dream of. I love it because it's very exposing of the actors. You're right in the middle of the audience. It's very demanding. You have to be good. You have to act with your back, with your shoulder blade, with your thigh muscle, with your calf muscle. It's total.
Why go to the trouble of re-creating the Royal Shakespeare Theatre here?
It was partly pragmatism, getting the work up and running really quickly for a festival. If we were coming for an autumn season, I don't think we would have needed to do that. We would have taken our time and adapted the shows for different spaces. But when we have to get a repertoire of plays up and lots of performances of them over a period of not much more than six weeks, we had to get our skates on and that was only possible by staying on a blueprint that was very similar to our own.
How receptive are New Yorkers to the Bard's work?
New York is one of the Shakespeare capitals of the world, which is one very good reason to play here. Free Shakespeare in the Park every summer is one of the democratic glories of New York and has over the years encouraged a growing appetite for the strongest canon of work in world drama. We are currently talking to both the Public and Theatre for a New Audience about Shakespeare collaborations. We have worked closely with our friends at TFNA for many years and have presented two of their excellent productions in Stratford already.
As someone with extensive Shakespeare experience, how do you approach a new production?
I try to be as innocent as I possibly can. I literally try and find out what it is. What's going on in it? Of course that means some very proactive work of thorough reading. I'm lucky now in that I have a fairly robust understanding of the cultural context in which Shakespeare was writing, including the fact that he couldn't be overt always about what he was talking about. He had to just about all the time write almost in code in order to get his plays on. He was the only playwright of his generation not to be imprisoned, killed in a duel, tortured or arrested. Shakespeare was the genius survivor and his plays are a slalom between the dangerous bear traps that existed for writers at that time. So you're looking for: where's that metaphor leading? It's beautiful but what's its meaning?
What else do you plan to do while in the city?
Once the season is up and running, I'm most looking forward to finding another layer of meaning and joy in our productions, shopping at Zabar's and then collapsing on a beach at the far end of Long Island.


text:
USER EDITORneomichel
User Score: 135
Spencer borrows some of Ezra's spy tools, and Emily's mom invites Ali to dinner. Meanwhile, Aria does a little volunteer work at a mental hospital and crosses paths with an aggressive patient. Ali clashes with Caleb, which makes things awkward for Hanna.moreless
After Caleb comes back to Rosewood, he determines whether staying is the right thing to do. Alison is feeling awfully scared and considers leaving Rosewood for her safety, but the girls need her there in order to protect her. Ezra commits to finding answers through research of the past and present.moreless
In the fifth-season opener, a wounded Ezra heads the hospital, where Aria stays by his side because his knowledge about "A" puts him in additional peril. Meanwhile, her friends set a trap for "A" and are surprised by who wanders into it.moreless
After years of searching for answers and being tortured by A in every way, the girls finally get the key to all the secrets around Ali's disappearance 4 years ago. But the mystery of A's true identity still haunts them. Will Spencer, Emily, Aria and Hanna be clever enough to finish the puzzle and expose who A really is? Will Ali finally get to come back home safe and sound for good?moreless
All four of the Liars are dealing with romantic issues when a charity bridal fashion show hosted by Mrs. DeLaurentis presents itself as an opportunity to gain proximity to her, her house, and Ali's secrets. The girls take advantage of the opportunity as Ella and Jason arrive back in Rosewood.moreless
While Spencer and Aria are on the mend, Emily and Hanna put on their detective caps. Emily tries to uncover what's behind Ezra and Mona's relationship, while Hanna gets herself involved with new clues in Ali's case revealed to her by Detective Holbrook.moreless
All the Liars rally around Aria, who is falling apart after finding out Ezra's true motives. Meanwhile, Spencer attempts to convince her parents and Toby that she can overcome her bad habits independently.moreless
Spencer hits rock bottom and Aria spirals out of control when the ultimate betrayal shatters both of them. Has the past finally caught up with them? Has Ali's attempted murderer been exposed? Is Mrs. DiLaurentis harboring a dirty little secret that could completely unravel Aria, Spencer, Emily and Hannah's lives?moreless
Spencer's countless sleepless nights due to her abuse of prescription pills are starting to catch up with her. She time travels her way back into the black and white 1940's Film Noir with her friends, where her mystery solving skills are put to the test! But in this altered reality of trench coats, 15 cent coffee, and pin curls, can Spencer put all of the pieces together to finally find out the truth about Ali?moreless
Since the new discovery, Spencer starts struggling with sleep and turns to a couple classmates with her problem. Hanna is worried about Spencer because her behavior is getting out of control. After the bad confrontation with Alison, Emily tries to mend fences and asks for another chance. Ezra is still on his mission and Aria's many fibs begin to weigh on her and she has no clue what to do.moreless
User Score: 135
User Score: 563
User Score: 216
User Score: 180
User Score: 164
User Score: 84
User Score: 75
User Score: 61
User Score: 59
User Score: 59
User Score: 39
User Score: 36
User Score: 35
User Score: 33
User Score: 29
User Score: 23
User Score: 20
User Score: 20
User Score: 18
User Score: 17
No results found.
No results found.
No results found.

subset: commoncrawl


text:
Walnut Tarts
14 Nov 2009
|Sugar crust pastry
|3 Tablespoon
|All purpose flour
|1⁄3 Cup (5.33 tbs)
|Maple syrup
|1 Cup (16 tbs)
|Hot water
|1 Cup (16 tbs)
|Vanilla extract walnuts
|1⁄2 Teaspoon
|Whipped cream
|1 Cup (16 tbs)
|1⁄4 Cup (4 tbs)
Preheat oven to 350 °F (175 °C).
Line tart molds with crust.
Bake in oven 15 minutes.
In a saucepan, melt butter.
Add flour.
Mix until butter is absorbed.
Add syrup and hot water.
While stirring, bring to a boil.
Reduce heat.
Simmer 7 minutes or until mixture thickens and becomes translucent.
Stir occasionally.
Remove from heat.
Let cool completely.
Mix in vanilla extract.
Pour into molds.
Garnish each tart with walnuts, 2 tbsp (30 mL) whipped cream and cocoa.
Rate It
0 Comments
Walnut Tarts Recipe


text:
EA Sports Season Ticket to include additional $100 of content
EA Sports has announced an expansion of its Season Ticket deal. The cost of the annual subscription remains unchanged at $25 or 2000 MS Points, but will this year include 24 Premium Gold packs for each Ultimate Team mode in FIFA 13, Madden NFL 13 and NHL 13, plus yet-to-be detailed content for Tiger Woods 14 and NCAA Football 14. That's on top of the usual three day early access and a 20% discount on all premium DLC content. Full details available here.
Thanks, G4.
Sometimes we include links to online retail stores. If you click on one and make a purchase we may receive a small commission. For more information, go here.


text:
There are 0 results with the tag: artician+pro
Sorry! The word "artician+pro" does not have any tags - Seems like you could be the first to create it!
Complete Privacy
Your privacy options are important.
Upgrade your QuarkXpress 8 - or use Indesign 5 to animate your documents.
Enhance 3D objects with Adobe Creative Suite 5 - use Lightroom 3 for superior noise reduction


text:
something is up the Responsive Theme it is not loading properly on some Cell phones
I tried to acces it through Blackberry, and it doesn't direct me to the home page
it takes me to another page showing the last posts and the Menu Bar is not work properly..
i don´t know what to do!! Help me obi wan kenoby, your my only hope!
I tried to post this question on the themeID Forum, registered but never send me the email with the password, that is why i haven't posted this on there.


text:
The Cloaked Sailor by DarkSilverflameWatch
©2011-2016 DarkSilverflame
A cloaked sailor, standing at the bow of his ship, gazing out onto the ocean.
(It's the belly and wing feathers of a Greylag Goose upside down)
(It's the belly and wing feathers of a Greylag Goose upside down)
realer than real
nice feathery. that is a prize shot.
really nice
well, were do i start , let me start by saying how much i love this shot you made, and i did not say you took , for this came from your hearth to your brain down your arm to your hand down your fingers to your camera to our hearths, need i say more.
Don't forget to read my story by the way I like your picture
I love the shades.
Love this concept and photograph!!!!
Great eye for seeing something different than what would be expected. Love how the feathers pop in this B/W shot.
Awesome work with very great detail
Lovely gallery, and thank ye for the fav
very crisp. Much love.
very crisp. Much love.
beautiful macro!
What a fluffy boat! Great perspective!
Me gusta!
really beautiful
The lighting in this is intense! Great shot.
very interesting shot. love it
I like the way your mind works.
that's super cool. I thought it was a viking boat or something on the small thumb
amazing !!
Nice concept!
i feel like touchging the real thing
Wunderbares Detail, toll gesehen
I love how evocative your concept is! The flow of the feathery texture plays quite wonderfully with how my eye is drawn across the image!
A person who sees things most others wouldn't, aren't you? A beautiful shot even without it being a goose, and remarkable idea.
It's great! I love it
This is so beautiful. I thought it was a boat.
this is so amazing!
Clever interpretion of an inverted pic! Definitely has a Viking longboat vibe going on to my eye! Downy whites look like roiling clouds, the bottom feathers splashing waves. There might also be a sense of a headlong rush off the edge of the world?
very cool, the diversity in grey is really amazing
I love the shadows! It's really awesome!
georgeous image.
I love the contrast, and the neat way the feathers come together. Nice shot.
Is that a butt? o.0
Love the textures of the feathers and the repeating pattern of feathers in general. Imaginative metaphor.
This is really special... awesome perspective. Havent seen anything similar.
I do like that - great use/interpretation of something otherwise very familiar
Absolutely breathtaking. I love how you subtly shot the picture so it looked like a sailboat...
love the interpretation. Great shot too.
this one is incredible. it seems like the front of a little boat !
Original....very creative......fantastic detail...... excellent.
great stuff!!!....killer gallery!!....love it!


text:
Top Definition
a girl who is an amazing friend and won't turn on you for no reason. she is pretty, even when she doesn't think so. and has cool blue eyes. and she is a dolphin.
did you see camielle at swim practice? she was amazing!
by jmakk February 14, 2010
Trending Now


text:
An Improbable Pair on a Quest Into the Past
By WENDY PERRON
Published: June 4, 2000
FROM opposite ends of the dance universe come two superstars: Mikhail Baryshnikov and Yvonne Rainer. He from the purest centuries-old classical tradition, she from the rule-breaking Judson Dance Theater of the 1960's. He the prince of Russian ballet; she the high priestess of the American avant-garde. He known for his natural theatricality, she for her resistance to anything theatrical.
They are rehearsing together for a season of the White Oak Dance Project, of which Mr. Baryshnikov is founder and director as well as lead performer, at the Brooklyn Academy of Music from June 7 to 11. In addition to a new work by Ms. Rainer, there will be premieres by Mark Morris and John Jasperse and Trisha Brown's ''Glacial Decoy'' (1979). How did it happen that Baryshnikov asked Rainer, who had not choreographed a dance in decades, to contribute to this program?
In the last 25 years Mr. Baryshnikov has journeyed deep into the repertory of American modern dance, while Ms. Rainer, in the last year, has returned to the dance studio after 25 years as a noted feminist filmmaker. Since its inception in 1990, White Oak has commissioned 40 new dances from modern choreographers, starting with its initial resident choreographer, Mark Morris, and on through Lar Lubovitch, Maurice Bejart, Kevin O'Day, Neil Greenberg and Lucy Guerin. Last fall Mr. Baryshnikov, 52, came to Judson Memorial Church in Greenwich Village when Ms. Rainer, 65, danced in a new version of her seminal ''Trio A'' (1966), a five-minute continuous phrase in which the dancers never look out at the audience. Planning a program for this fall featuring choreographers from Judson Dance Theater, legendary as the incubator of postmodern dance, Mr. Baryshnikov invited Ms. Rainer to choreograph something.
''When I came to see White Oak and met him, I was surprised and pleased that he was familiar with the titles and the personnel of my past work,'' Ms. Rainer said recently during a rehearsal at the Trisha Brown Studio near Columbus Circle in Manhattan. ''He'd done his homework. I said I could give him 'Trio A' and 'We shall Run' (1963). Then he said, 'Maybe you'd like to do a new piece.' I gulped. And then it began to obsess me. What would I do?'' Separated by a quarter-century from her work in dance, she went home and riffled through her book ''Work: 1961-1973'' to gather bits and pieces from her past artistic life that could be rearranged. Harking back to the Dadaist method of fragmentation, Ms. Rainer chose a collage structure to contain the selections. Like much of her work in both dance and film, the ideas and images are presented not in a beginning-middle-and-end format, but in a series of radical juxtapositions of tasks, interactions and spoken texts.
Ingredients for this collage, titled ''After Many a Summer Dies the Swan,'' are drawn from ''Three Satie Spoons'' (1960), ''The Bells'' (1961), ''The Mind Is a Muscle'' (1968) and ''Continuous Project -- Altered Daily'' (1970). Actions may be simultaneous, deflecting attention from one another, or sequential. One section, in which dancers cushion one another's movements with pillows, has a goofy precision. In another, two women link arms around each other's waists as they repeatedly melt to the floor and rise, still attached. They are reciting, in falsetto, a Gertrude Stein-ish bit of text by Rainer: ''That was so lovely.'' ''Yes yes that was so lovely.'' ''It was so lovely it will make me think about it a lot.'' ''In fact we will write about all that thinking,'' and so on. Rainer advises audience members: ''You kind of roll with the different elements that keep coming to the surface and disappearing.''
Seeing Ms. Rainer and Mr. Baryshnikov in a studio together makes perfect sense. Both have short spiky hair, long torsos and arms, boyish bodies. When they kissed each other hello they seemed to be exactly the same height, and their rehearsal demeanor has a similar balance of readiness and calm. They understand each other's physicality, and more, they seem to understand each other's state of mind. Ms. Rainer said, ''He has this restless intellect that's led him into this 60's corner of dancing.'' He affectionately called her a ''professional revolutionary,'' and added, ''It's fun to see such passion in her.''
While rehearsing the group sections, the six White Oak dancers -- besides Mr. Baryshnikov, they are Raquel Aedo, Emily Coates, Roselynde LeBlanc, Michael Lomeka and Emmanuele Phuon -- have vivid personalities and dance technique to burn, but Mr. Baryshnikov shows slightly more relish for the movement than the younger performers do. A high point of the piece is sure to be ''Valda's Solo,'' originally from Ms. Rainer's first film, ''Lives of Performers'' (1972). Here, it reveals Mr. Baryshnikov in a different mood. He wears a velvet gown, and lets a red ball roll off his hand and drop to the floor. Not much happens, but it's riveting. While the dancer and actor Valda Setterfield looked elegant and aristocratic in the film, Mr. Baryshnikov looks lonely and pensive, creating an aura of melancholy.


text:
Definition of Kintyre in English:
A peninsula on the west coast of Scotland, to the west of Arran, extending southwards for 64 km (40 miles) into the North Channel and separating the Firth of Clyde from the Atlantic Ocean. Its southern tip is the Mull of Kintyre.
Words that rhyme with Kintyreacquire, admire, afire, applier, aspire, attire, ayah, backfire, barbwire, bemire, briar, buyer, byre, choir, conspire, crier, cryer, defier, denier, desire, dire, drier, dryer, dyer, enquire, entire, esquire, expire, fire, flyer, friar, fryer, Gaia, gyre, hellfire, hire, hiya, ire, Isaiah, jambalaya, Jeremiah, Josiah, latria, liar, lyre, Maia, Maya, Mayer, messiah, mire, misfire, Nehemiah, Obadiah, papaya, pariah, peripeteia, perspire, playa, Praia, prior, pyre, quire, replier, scryer, shire, shyer, sire, skyer, Sophia, spire, squire, supplier, Surabaya, suspire, tier, tire, transpire, trier, tumble-dryer, tyre, Uriah, via, wire, Zechariah, Zedekiah, Zephaniah
For editors and proofreaders
Line breaks: Kin|tyre
What do you find interesting about this word or phrase?
Comments that don't adhere to our Community Guidelines may be moderated or removed.
= trending


text:
"I've used tiny prints for the past 6 years and they are the best quality and best options of any card company I've found. Very satisfied"
"We use Tiny Prints every year for our holiday cards and every year we get rave reviews from our family and friends; this year being no different. Tiny Prints gives us the best selection of designs to choose from, no matter if we decide to do a traditional card one year or vintage the next. It's my favorite site to buy cards from and the quality is exceptional!"
"What a lovely, simple card. I picked the green/red option and sent them as my annual Christmas card. Photo quality, paper quality, expedited shipping and customer service were superb. I wish I could have put a tiny photo on the back but overall, lovely card. Will order from Tiny Prints again."
"Loved everything about this card. The rounded corners and soft colors made this year's holiday greeting feel even more special."
"Everything was good. The designer helped to get the entire photo on the card. The person that took the order helped upload the photo because i was having trouble. The quality of the card stock is excellent. I felt it darkened the photo a little. On the whole, a very good product! Very happy!"


text:
I'm trying to troubleshoot an issue (or at least what I perceive as a strange behavior).
1) If I update something in my the
functions.php file of my theme, the change is immediately transfered to my website. ALL I need to do is empty the page cache and minify cache. That's it. And I'm using Amazon CloudFront as my CDN (push method).
2) Now, if I change something to my
style.css file... that's something entirely different. Even if I ask, as an administrator, never to be served cached page nor files from the CDN... the modification won't show. I can empty all the cache I want, enable and disable the CDN, deactivate and reactivate W3TC... nothing will do. I'm still serve the old
style.css I even try and purged the file from the CDN. Nothing.
Why would
functions.php be refresh so fast and not
style.css while both belong to my theme folder?
Thanks a lot!


text:
Type: Posts; User: webshowcase
Very good. If you learn't something the time spent is definitely worth it.
Did you get the firebug extension for firefox?
Thanks mordauk appreciate your comment.
Hi all,
Looking for some feedback on www.webmastershowcase.com.au
Site kicked off a little over a month and a half ago and has had a good response so far.
Site uses pligg cms
No problems.
If you are using firefox as your browser download an addon called firebug. It will help you to quickly diagnose problems like these in future.
Glad you sorted it.
Cheers, Ed
I think this css code may be causing you some issues. padding-left:40px
try removing the class="c2" from your html
Other than this i cannot see any issues with you menu.
Add this to your css file:
#container {
margin:0 auto;
width:990px; <--what ever width you decide
Add this to your html code just underneath the first body tag and ending just before the...
Just thought I would add that referencing things from your websites root directory is also a good thing to keep in mind. Especially for large websites that require pages to be moved around from time...
I had a similar issue a long time ago and it was a problem in the html. Try this code and see if it works.
<object type="application/x-shockwave-flash" data="yourfilename.swf" width="yourwidth"...
Are you sure your desktop files have updated on your server?
stylesheet and html?
I am seeing your menu fine with ie7 and firefox however, in ie7 there is a gap between the products drop down and...
To add to rnd me's suggestions alt tags are also considered very important to the blind.
Here is a good article from zdnet I came across the other day.
Topped computing studies at school. After no real previous experience it gave me a lot of confidence. Then i landed in a tafe course and got a really good feel for web languages including html,...


text:
Endurance exercise and metabolism are linked to transcriptional activation of human telomeres, researchers propose.
Unmasking Secret Identities
February 1, 2014|
A tour of techniques for measuring DNA hydroxymethylation
February 1, 2014|
A tour of techniques for measuring DNA hydroxymethylation
January 23, 2014|
Researchers seek insight into the pigmentation patterns of guppies and zebrafish.
January 10, 2014|
Bacterial genes aid tubeworm settling; pigmentation of ancient reptiles; nascent neurons and vertebrate development; exploring simple synapses; slug-inspired surgical glue
December 26, 2013|
A look at 2013's noteworthy new species
November 1, 2013|
Assistant Professor, Physics, Princeton University. Age: 39
October 25, 2013|
Researchers show that genetic enhancer elements likely contribute to face shape in mice.
September 6, 2013|
Biology students discover a new species of beetle in the giant city of Manila.
August 29, 2013|
Two new species of closely related electric fishes discovered in the Amazon produce very different electrical signals: one AC, the other DC.
August 19, 2013|
Pseudomonas aeruginosa gather swarming speed at the expense of their ability to form biofilms in an experimental evolution setup.
August 13, 2013|
Pluripotent cells can help regenerate tissues and maintain long life—and they may also help animals jumpstart drastically new lifestyles.


text:
Type: Posts; User: acc
If possible(motor is good and belt)the free wheeling fans,
usually spin backwards.Turn the fan on, then off,and wait for wheel to stop.
just curious if any ones been down to the baja 1000
and checked out some of the racing.
the thin red line
devels brigade
ive never seen boilers installed outside.
i know that even the slightest of wind currents(such as
strong outside winds blowing thru fresh air openings,with
no ducting)will effect the combustion...
i heard the fish are jumping out of that sess pool on to
land.and a few people have died from infected cuts.
they gota get out.
if equipped with economizer,checkout the enthalpy control.
a few times ive seen this control short out/loose circuitry
causing low contactor voltage/chattering-contactor/compressor on/off/on/off...
they will fax u diagrams
will it work in place of 134a?in a car.
or will the oil have to be replaced?
yea,ther was one show with the mit students,who used card counting.they were in a foriegn country,and the security
thought they were wired with spy stuff.So they forced him to strip,and then a lady...
johnee be good and madison blues by good ole george theroggood(sppelling?)
GCS i think it should be.
7 1/2 ton
250 000 btu heat
call lennox to be safe
i went on a tour if an ammonia refrigeration plant once.
i coudnt believe the size of these compressors.
there was a service guy working in the sump of one of them.
they were using chain falls for...
hidden latent heat of server cows-
has al bundy put it-peg,i almost drowned in the pools of sweat,bettween the folds.
with these larger servers.size the multi ton chiller accordingly.
me too.you pick up the wheel,it looks fine.
put it in and the whole roof shakes.
what a waste of time dissasembling and p/u another wheel.
just curious how others here check out new wheels?
whats the fireye m#?
is the amplifier replacable?
5 ton-call lennox to be safe
69=181 in metric
at least there wasnt 2 ft of snow up there,now thats fun.
two wheeled dollie and lots of rope-always in truck.
yes,should be on wall of pride-good job.
i once checked a filter,out of curiosity,in a vegas hotel,
i swear there was over an inch of **** built up on it.
have you met my two friends>smith and weston
quite a few times,i see no economize filters installed,makes
a mess on the econ controls from the elements.
not sure how old the listings are?no dates
I think they beamed down again,check it out:
Sonc,this might help with the wiring,or temprite contacts?
what is the btu rating of that heater?
you may not need the proof of closure in your application.
if there are two main auto gas valves ,you might be ok?
modifying manufactures wiring,may also be a code issue?...
my wife tells me to take the garbage out,i tell her you cooked it you take it out.
would this be a roots meter,with a digital read out?,
im curious to on how to read these-ive seen only one.
hope all of you down there stay safe.
i cant believe people are out during this.
i just heard from the news,one car got tossed into the drink,off a bridge,
emergency workers not going out,saying...
I finally gave in and went to medic. Blood tests show no infection and slightly high uric acid(gout) and of course inflammation. They put me on an antibiotic and and inflammatory medicine.
we service a few small self contained coolers.
Converted 2 to 414b with no problems.
One single door self contained freezer,r12 all leaked out.
Could i use 414b?
I dont want to buy another jug of...
do those carrier units have a centrifical switch for air proofing comb air
if the wheel rusts out a little=more condensation
when quoting these,make sure you add in the internal hx parts,not...
-samuri delicutesent
-samuri divorce court
-barney miller
-wkrp(johny feevers response time gets faster,with state troopers alchohol reaction test)
-cloths pin and cards in banana seat bike...
Easiest way I find is to lift one side of the comp. and slide under a piece of deep unistrut on top of bolts then repeat for the other side, the comp is sitting on top of the unistrut which is held...
one company i new,used a shop boy.He would deliver/pu parts/materials to differeant job sites.In the mornings,the installation crews would p/u material from the shop and sign for them.The shop guy...
throw in a mars bar and really check the strength
posting pictures
finally posted a picture using preview post button,after pulling a few hairs out,thanks to james 3528,who suggested in previous posts to,right click on your picture to get the...
this isnt a refrigeration story,but ill share it anyhoww
what a great site,all your storys are a laugh
worked with a guy who used to do residential water heaters
he gets a call for no hot...
i find spinner caps sieze to often
they have to be re-lubricated few times per heating season
ive only installed one and will not do anymore
when they do sieze,and the wind changes...
what type of valve are you replacing.
some valves,like the b and g zone valve,have a replacable
valve kit so the valve body does not have to be changed
you can close your header valves,relase...


text:
Christmas Joy For The FevolasTrix
The Christmas holiday was just a little sweeter for Brendan Fevola and his wife Alex.
The couple welcomed their third child together on December 21. Their little girl weighed in at 7 lbs 5 oz and is doing very well.
The baby has two big sisters, Mia and Leni, waiting to to big sister her all over the place.
Congrats to the family!
Article Posted 7 years Ago


text:
Beneful® Dry Dog Food IncrediBites® with real beef225 Reviews
Fill your dog's bowl with protein-rich nutrition and you're giving him 100% of the nutrients he needs to help him thrive every day, all in a mix of tender and crunchy minibites for small dogs. It's everyday healthy and all kinds of yum.
Available in 3.5 lb, 6.3 lb, and 15.5 lb bags
with real beef accented with carrots & peas
Viewing 2 of 225 Reviews
Nutritional Information
Ground yellow corn, chicken by-product meal, corn gluten meal, whole wheat flour, animal fat preserved with mixed-tocopherols, beef, rice flour, soy flour, meat and bone meal, propylene glycol, sugar, salt, mono and dicalcium phosphate, phosphoric acid, tricalcium phosphate, potassium chloride, animal digest, sorbic acid (a preservative), dried carrots, dried peas, non-fat yogurt, calcium propionate (a preservative), choline chloride, L-Lysine monohydrochloride, Vitamin E supplement, zinc sulfate, ferrous sulfate, manganese sulfate, Red 40, niacin, Vitamin A supplement, Yellow 5, Yellow 6, copper sulfate, Vitamin B-12 supplement, calcium pantothenate, Blue 2, thiamine mononitrate, garlic oil, pyridoxine hydrochloride, riboflavin supplement, Vitamin D-3 supplement, menadione sodium bisulfite complex (source of Vitamin K activity), calcium iodate, folic acid, biotin, sodium selenite.
Manufactured by: Nestlé Purina PetCare Company, St. Louis, MO 63164 USA
Beneful® IncrediBites® With Real Beef is formulated to meet the nutritional levels established by the AAFCO Dog Food Nutrient Profiles for all life stages.
Guaranteed Nutrition
27.0%Crude Protein (min)
12.0%Crude Fat (min)
4.0%Crude Fiber (max)
14.0%Moisture (max)
1.1%Calcium (Ca) (min)
0.2 mg/kgSelenium (Se) (min)
12,500 IU/kgVitamin A (min)
150 IU/kgVitamin E (min)


text:
Excellent view of the city! Like! Greetings Nick
My Dear Panoramio Friends Thank you very much for your visit and nice comments. Warm greetings, Ahmet
Great scenery YSL Best wishes from Athens,George
Beautiful photo
Best wishes
Beautiful and impressive view of the city !
LIKE, Greetings
Photo taken in Istanbul, İstanbul, Turkey


text:
Swirled Cheesecake Brownies
Made with whole-wheat flour, these decadent-tasting brownies have a beautiful marbled cheesecake topping. Cutting them into bite-size pieces helps to keep the calorie count in check.
- 4 ounces reduced-fat cream cheese, Neufchatel
- 1/4 cup sugar
- 1 large egg
- 1 tablespoon all-purpose flour
- 1 tablespoon nonfat plain yogurt
- 1/2 teaspoon vanilla extract
- 2/3 cup whole-wheat pastry flour
- 1/2 cup unsweetened cocoa powder
- 1/4 teaspoon salt
- 1 large egg
- 2 large egg whites, or 4 teaspoons dried egg whites, reconstituted according to package directions
- 1 1/4 cups brown sugar, packed light
- 1/4 cup canola oil
- 1/4 cup coffee, strong or prepared instant, or black tea
- 2 teaspoons vanilla extract
- Step 1
- Preheat oven to 350° F. Coat a 7-by-11-inch brownie pan or baking pan with cooking spray.
- Step 2
- To prepare topping: Place cream cheese in a small mixing bowl and beat with an electric mixer until smooth and creamy. Add sugar and beat until smooth. Add egg, flour, yogurt and vanilla; beat until well blended.
- Step 3
- To prepare brownie layer: Whisk whole-wheat flour, cocoa and salt in a bowl. Place egg, egg whites and brown sugar in a large bowl and beat with the electric mixer on medium speed until smooth. Add oil, coffee (or tea) and vanilla; beat until well blended. Add the dry ingredients and beat on low speed just until well blended, stopping once to scrape down the sides.
- Step 4
- Scrape about half of the brownie batter into the prepared pan. Slowly pour the topping evenly on top. Drop the remaining brownie batter in large dollops over the topping. Draw the tip of a sharp knife or skewer through the two batters to create a swirled effect.
- Step 5
- Bake the brownies until the top is just firm to the touch, about 20 minutes. Let cool completely in the pan on a wire rack. Coat a knife with cooking spray and cut into 24 bars.
© Meredith Corporation. All rights reserved. Used with permission.
For more recipes go to EatingWell.com


text:
UNDERWATER LED LIGHT STRIP 4" - Seachoice
This item is found in the following Product Families
Underwater LED Light Strips - Seachoice
Did you know that light can attract bait? Install tiny LED lights below the waterline, and get a good catch. The easy-to-install Underwater LED …
Dimensions: 4" x 1/2"
Do you fuse protection? If so, what amp?
Seachoice says there is basically no draw to them so a 5 amp is all that would be needed to protect it.
This product ships in 1 business day.
Add to Cart and enter your Postal Code to determine the shipping charges and estimated delivery date.
Most products and orders leave our warehouse in 1 business day. However, select items may take more processing time. Alaska and Hawaii orders please add 1 additional warehouse processing day.
Standard Shipping Policies


text:
FiltersShow / Hide
- All Events
- Music
- Comedy
- Theatre & Shows
- Sport
- Cinema
- Festivals
- Days Out
- Edinburgh Fringe
- Anywhere In The UK
- Location: Anywhere in the UK
Radius: ... miles
This event has been and gone!
Catch the next one:
Check out the info below for future tour dates, and track them to receive alerts when they tour near you
Never miss another 'Michael Portillo' show
Life - A Game Of Two Halves : Michael Portillo
A talk from former Conservative MP Michael Portillo, followed by a Q&A.
Michael Portillo
Controversial former Conservative MP for Kensington and Chelsea who regularly appears on TV and is a successful columnist.
Michael Portillo tour dates
Track this event
- Event has been added to your calendar
- Any important updates will be sent to your email address
- Add to your personal Ents24 calendar
- Sync with iCal, Outlook and others
- Receive important updates
Venue Facts
Venue: Warwick Arts Centre
Website: warwickartscentre.co.uk
Bookings: 024 7652 4524
Disabled Bookings: 024 7652 4524


text:
|EMAIL: firstname.lastname@example.com
Grades will be posted in Gradebook for grades 4-12 according to the following: Minor Assessments within one week of assessment. Major Assessments posted by the 15th or 30th of the month depending on date of assessment completion (these assessments include major projects, summative assessments, research papers/projects, major essays, etc). Student work will be returned in a timely manner coinciding with grade posting. PLEASE MAKE SURE YOU CLICK ON THE GREEN LOGIN BUTTON AND NOT CLICK ENTER ON YOUR KEYBOARD WHEN TRYING TO LOG INTO THE PARENT SITE.


text:
The (POGO) Blog
December 17, 2015
By Neil Gordon
Many Top Federal Contractors Have Human Rights Violations
As Human Rights Week wraps up, we invite the public to explore our Federal Contractor Misconduct Database for instances in which the federal government's largest suppliers were alleged or found to have violated basic human rights and freedoms.
Continue Reading Many Top Federal Contractors Have Human Rights Violations
Topics: Contract Oversight
December 14, 2015
By Jacob Marx
Safety Board Slams Pantex for Lax Emergency Preparedness
Pantex's disaster preparedness problems include a lack of training for staff, poor communication with public safety personnel, and inefficient decision-making tools for emergencies.
Continue Reading Safety Board Slams Pantex for Lax Emergency Preparedness
Topics: National Security
December 15, 2015
By Neil Gordon
Federal Fraud Recoveries Drop More than 38 Percent
In fiscal year 2015, the Department of Justice recovered more than $3.5 billion in cases involving fraud against the government—a dramatic decrease from the previous fiscal year's total.
Continue Reading Federal Fraud Recoveries Drop More than 38 Percent
Topics: Contract Oversight
December 15, 2015
By Mia Steinle
EITI Report Shows Impact of Resource Extraction on Taxpayers
The U.S. Extractive Industries Transparency Initiative (EITI) released a report on oil, gas, minerals, and renewable resources, and made data about those resources available to the public.
Continue Reading EITI Report Shows Impact of Resource Extraction on Taxpayers
Topics: Energy and Natural Resources
December 14, 2015
By Neil Gordon
Visualizing 20 Years of Contractor Misconduct
POGO's Federal Contractor Misconduct Database comes alive in an online interactive graph.
Continue Reading Visualizing 20 Years of Contractor Misconduct
Topics: Contract Oversight
Stay Connected
Browse POGOBlog by Topic
POGO on Facebook
POGOBlog Contributors
Latest Podcast
Fly Before You Buy: Tom Christie on Realistic Combat Testing
The Project On Government Oversight's Dan Grazier recently sat down with Tom Christie, a former Director of Operational Test & Evaluation at the DoD from 2001-2005, to talk about the critical need for realistic combat testing before the Pentagon buys new weapons.


text:
Professional weirdo Patton Oswalt is no stranger to being the best at Twitter. In fact, his Twitter skills are so advanced, that even his Twitter typos are no ordinary Twitter typos — they're career-enders.
After terminating his own employment, Oswalt then invited other Twitter users to follow suit with the shenanigan-friendly hashtag #CareerEndingTwitterTypos.
It wasn't long before his comedian friends and followers started offering up their own submissions and the whole thing became a certifiable trend.
Oswalt's handpicked favorite are collected below. Caution: If you're planning on joining the festivities don't forget to leave room for the hashtag, or else you may actually jeopardize your job.
[H/T: Uproxx]


text:
Joe Foy
Joseph Anthony Foy
Position: Third Baseman
Born: February 21, 1943 in New York, NY
High School: Evander Childs HS (Bronx, NY)
School: Lehman College (Bronx, NY)
Signed by the Minnesota Twins as an amateur free agent in 1962. (All Transactions)
Debut: April 13, 1966 (Age 23.051, 10,056th in MLB history) vs. BAL 3 AB, 0 H, 0 HR, 0 RBI, 0 SB
Rookie Status: Exceeded rookie limits during 1966 season [*]
Teams (by GP): RedSox/Royals/Mets/Senators 1966-1971
Last Game: May 27, 1971 (Age 28.095) vs. BOS 2 AB, 0 H, 0 HR, 0 RBI, 0 SB
Died: October 12, 1989 in Bronx, NY
Buried: Woodlawn Cemetery, Bronx, NY
View Player Bio from the SABR BioProject
About biographical information
Our primary support comes from users like you. Sponsor this page for $10. Your message will replace this ad.


text:
|Home | About | Journals | Submit | Contact Us | Français
In the early days of the HIV epidemic, it was observed that a minority of the infected patients did not progress to AIDS or death and maintained stable CD4+ cell counts. As the technique for measuring viral load became available it was evident that some of these nonprogressors in addition to preserved CD4+ cell counts had very low or even undetectable viral replication. They were therefore termed controllers, while those with viral replication were termed long-term nonprogressors (LTNPs). Genetics and virology play a role in nonprogression, but does not provide a full explanation. Therefore, host differences in the immunological response have been proposed. Moreover, the immunological response can be divided into an immune homeostasis resistant to HIV and an immune response leading to viral control. Thus, non-progression in LTNP and controllers may be due to different immunological mechanisms. Understanding the lack of disease progression and the different interactions between HIV and the immune system could ideally teach us how to develop a functional cure for HIV infection. Here we review immunological features of controllers and LTNP, highlighting differences and clinical implications.
Prior to the introduction of combination antiretroviral therapy (cART) it was observed that a minority of the individuals infected with Human Immunodeficiency Virus type 1 (HIV-1, from now on referred to as HIV) did not progress to Acquired Immunodeficiency Syndrome (AIDS) or death. This minority maintained normal CD4+ cell counts in the absence of treatment for several years—in some cases for more than two decades (reviewed in [1]) and therefore the terminology Long-Term Nonprogressors (LTNP) was proposed. When the technique for measuring the viral load was introduced it became evident that some of these patients, who did not clinically progress, had low or even nondetectable viral replication. This phenomenon leads to the additive definition of the non progressor-phenotype referred to as controllers due to their ability to control viral replication in the absence of cART. Today, non-progressors are a collective name for controllers and LTNP who are clinically similar. Except for certain demands for the duration of the infection in LTNP, they are only to be differentiated according to control or not of viral replication, respectively. Understanding the mechanism for the lack of disease progression in controllers and LNTP could ideally teach us how to develop a functional cure for HIV infection, and for this reason these subpopulations of HIV-infected patients have gained immense interest.
Non-progressors are described to differ from progressors in genetics, virology, and immunology. Genetically, certain factors seem to predispose to non-progressions. Thus, it has been shown that female gender, the presence of CCR5-delta32 polymorphism, and HLA genes, in particular the HLA B57 allele, are overrepresented among non-progressors ([2–9], reviewed in [10]). Virologically, a number of studies have indeed shown that some non-progressors are infected with less virulent strains of HIV resulting in a more benign infection [11–14]. However, there are now several lines of evidence that the majority of non-progressors are infected with replicant-competent virus [15–17]. One study has shown that CD4+ cells from controllers are less susceptible to HIV compared to CD4+ cells from progressors and healthy controls [18], while another study showed that CD4+ cells from controllers were as susceptible or even more susceptible to HIV entry and productive infection [19].
Thus, genes and viral factors play a role in non-progression, but these components do not provide a thorough explanation. For this reason the immune system is to be considered a key element in non-progression. This is supported by the recent demonstrations of better control of hepatitis C virus (HCV) in HCV-infected controllers compared to HCV-infected progressors [20, 21]. The immunological response to HIV infection can be divided into (1) an immune homeostasis resistant to HIV in LTNP and (2) the immune-mediated control of the virus in controllers. However, despite these two possible interactions between HIV and the immune system both resulting in preserved CD4+ cell counts, few studies have compared immune homeostasis in LTNP and controllers. The scope of this paper is to describe immunology in non-progressing HIV infection and to propose involved immunological mechanisms in LTNP and controllers.
It is well-established that LTNP and controllers are different subpopulations [22–25], supporting the idea that different immunological mechanisms are responsible for the preserved CD4+ cell counts. LTNP and controllers are described as rare populations comprising few percentages of all HIV-infected individuals, and with little overlap between them [22–27], although the definition of the populations suffers from lack of consensus in terminology and inclusion criteria, impeding the comparison of findings.
Controllers can be further divided into elite controllers (EC) and viremic controllers (VCs), most commonly with HIV RNA <50 copies/mL and 50–2000 copies/mL, respectively, although variations with higher levels are found as well ([25], reviewed in[27, 28]). This is in particular a problem because LTNP can thereby be categorized as VC due to their often relatively low viremia. In addition, a central problem in defining the non-progressor phenotype is a complete lack of inclusion of the viral load, thereby including LTNP who fulfill controller-criteria with low or undetectable viral loads.
Patients need not necessarily be infected for a long period of time in order to be categorized as controllers. Thus, two measurements of a low viral load during one year are sometimes used as sufficient, whereas others demand duration of infection for several years. In contrast, LTNPs due to the nature of the case definition have a long duration of infection, most commonly a minimum of 7–10 years. Both groups present with a CD4+ cell count within the normal range (350–1600 cells/μL) [22, 23, 25, 29]. Due to the low prevalence of these non-progressors, it is tempting to relax the inclusion criteria. However, clinical outcomes seem to improve with the stringency of criteria, and it has been demonstrated that the clinical outcome for patients infected for 7 versus 10 years and with stable CD4+ cell counts is different. Thus, a better survival among LTNP defined by 10 years of stable infection versus 7 years is reported [25], suggesting that even 7 years of stable infection do not distinguish properly between true LTNP and progressors.
In this paper, unless anything else mentioned, the term "non-progressors" is used as a collective name for controllers and LTNP, while the term "controllers" is used for VC and EC. The LTNP term is only used when studied patients had substantial viremia above 2000 copies/mL and had been infected for a minimum of 7 years. Although 7 years may not be enough to exclusively distinguish LTNP from progressors, 7 years are chosen as most studies have used this definition. The duration of infection in controllers is not included in our definitions as we consider viral control at any time point to be a sufficient determinant for controller status (Table 1).
The CD4+ cell count in a given patient at any time is the result of production, destruction, and traffic between blood and lymphatic tissue, and when the destruction exceeds the production the CD4+ cell count decreases. Thus, LTNP and controllers may have differences in production, destruction, or distribution of CD4+ cells compared to progressors in order to maintain a normal CD4+ cell count.
T cells mature in the thymus, but they originate from hematopoietic progenitor cells (HPCs) in the bone marrow (BM). Thus, a functional BM is crucial for thymopoiesis. In the hope of developing a cure for HIV infection HPC has been given greater attention, even more so after the report on eradication of HIV by transplantation of CCR5-deficient HPC in the so-called Berlin patient [30]. HIV influences BM and HPC, and impaired hematopoiesis in HIV infection is well documented [31–34]. Furthermore, several studies have shown that some HPCs express the HIV receptors CD4, CXCR4, and CCR5 making them potentially susceptible to HIV infection (reviewed in [35]). HIV infection of HPC has recently been suggested [36], although the complexities of purifying and maintaining HPC in culture make it difficult to determine if these HPCs are actually infected, as signs of infection may be due to contamination with other cell types or maturation of HPC to monocytes during in vitro culture. However, HIV proteins seem sufficient to disturb the haematopoiesis [37]. Nevertheless, in addition to T cells, natural killer cells and B cells, including naïve B cells, seem to be depleted during HIV infection [38]. HIV-associated lymphopenia may therefore be explained by more upstream elements of lymphocyte development than reduced thymic output.
Circulating HPCs have been found to decrease with disease progression and to be associated with CD4+ cell count [39], supporting the idea of BM and HPC as being essential in preservation of CD4+ cell count and suggesting preserved haematopoiesis in non-progressors. The haematopoiesis has only been assessed in a single study of elite controllers (Table 2). This study included progressing as well as non-progressing EC. Interestingly, the progressing EC showed signs of exhausted lymphopoiesis compared the non-progressing EC measured as CD34+ cells and lymphoid-HPC [39]. This is supportive of a sufficient haematopoiesis as a contributing factor to non-progression in controllers. Also, it indicates that the viral replication itself is not the only reason for disease progression.
The CD4+ cell count is maintained by proliferation of already existing CD4+ cells or by de novo production in the thymus. Earlier, it was believed that the thymus was only active in childhood and replaced by fatty tissue with increasing age. It is now evident that the thymus can also be active in adulthood, particularly during circumstances with lymphopenia, as is the case with HIV infection [40, 41]. Often thymic function is assessed as T-cell receptor excision circles (TRECs) or as the naive CD4+ cell count. TRECs are stable circular DNA fragments that are excised during the formation of TCR in the maturing T cell in the thymus, and TRECs are not replicated during cell division. Thus, the more immature CD4+ cells the higher the TREC content. A large thymus on CT scans has been associated with a higher CD4+ TREC frequency in HIV-infected patients [42]. Thus, TRECs and naive cells are all reasonable indirect measurements of thymic size and output.
HIV leads to a disruption in the number and function of naïve CD4+ cells in blood as well as in lymphoid tissue [43–45]. To our knowledge, no studies of naïve cells have discriminated between controllers and LTNP. In non-progressors, similar and lower numbers of naïve CD4+ cells have been found compared to progressors [8, 46, 47], suggesting that the level of naïve CD4+ cells itself is not associated with non-progression (Table 2). In contrast, increased expression of the naïve marker CCR7, higher levels of central memory cells with preserved ability to secrete interleukin 2 (IL-2), and a much higher thymic output as defined by TRECs in EC compared to progressors have been reported [46, 48], supporting preserved thymic function in non-progressors. The contribution of a well-functioning thymopoiesis to non-progression is further supported by the findings of strong correlations between TRECs and non-progression in SIV-infected rhesus macaques [49]. Also, normal levels of memory cells and preserved IL-2 secretion capacities have been shown in non-progressing SIV-infected rhesus macaques compared to progressors [50]. For this reason, it seems plausible that the thymic function is better in non-progressors compared to progressors, improving their ability to maintain a normal CD4+ cell count. However, these findings only explain the preserved CD4+ cell count in non-progressors, not the viral control in controllers. In fact, the high thymic output may indirectly be a consequence of and not a reason for the low viral replication, since lower viral replication does not lead to the exhaustion of lymphopoiesis normally seen in progressors [39]. Thus, it would be of great interest to compare the thymic output in LTNP and progressors since both populations have viral replication. It is tempting to assume that one of the main differences between these progressors and LTNP is an extraordinary capacity to produce cells. This is supported by findings of higher levels of naïve cells in a study of slow-compared to fast progressors based on the slope of their CD4+ cell loss, although this did not reach statistical significance [51]. Likewise, a study of children with LTNP status displayed higher levels of naïve cells compared to progressors and controls [52].
Thymic output is dramatically reduced with age, and the naïve cells are increasingly generated from peripheral proliferation (reviewed in [53]). Proliferation of cells leads to a lower TREC count, and therefore naïve cells in older individuals have lower TREC counts [54, 55]. Thus, the reported loss of the non-progressor status in some individuals may be due to increasing age and thereby decreased thymic output, because the thymus is no longer able to meet the demands of a high production of cells. This is supported by the findings of an immune system in HIV-infected patients which is comparable to much older healthy individuals [39]. Also, high age is a predictor of poor immune reconstitution after initiation of cART [56].
Production of CD4+cells is influenced by Interleukin 7 (IL-7). IL-7 is crucial in the T-cell homeostasis, and the IL-7 responsiveness is determined largely by the presence or absence of the IL-7 receptor (IL-7R), which is present on most mature T cells [57]. A negative correlation between IL-7 and CD4+ cell count is described. Consequently, HIV-infected progressors have high levels of IL-7 and reduced levels of IL-7R compared to healthy controls [58, 59], consistent with the need for increased production of CD4+ cells and a down-regulation of the receptor due to high plasma levels. Thus, controllers would be expected to display a pattern of IL-7/IL-7R closer to healthy controls than to progressors. This is supported by findings of lower levels of IL7 in controllers compared to controllers who lost their controller status [60] and by findings of lower levels of IL-7R in progressors compared to non-progressors [47]. In contrast, it would make sense that LTNPs display a pattern of IL-7/IL-7R more like progressors than controllers, because the need for CD4+ cell replenishment would be expected to depend on the level of viral replication—infection and cell—turnover, which is supported by findings from our own lab (unpublished data) These results are compatible with a hypothesis of low viral replication leading to a reduced number of new CD4+ cells becoming infected. Thereby, the level of IL-7 does not increase, and the IL-7R expression stays high. However, further studies are warranted to clarify this.
Immune activation (IA) is a necessary and normal acute response upon infection with any pathogen, as an effort to avoid infection. However, in HIV-infected individuals it is well established that chronic IA is linked to and predictive of disease progression, and IA has an additive or stronger prognostic value than does CD4+ cell count or viral load alone [61–68]. The influence of IA on disease progression can be partly explained by elevated levels of senescent and apoptotic cells as a consequence of IA, thereby leading to increased loss of CD4+ cells.
Elevated markers of activation are to be found in most cell compartments, but especially expression of the surface markers CD38 and HLA-DR on CD8+ cells have proven to be predictive of disease progression [64–68]. Thus, IA is a central player in disease progression, as illustrated by the development of pneumocystic pneumonia in rats solely as a consequence of IA [69]. In light of this, it is obvious to assume that IA in non-progressors is different from progressors and partly explains lack of progression. IA is one of the more well-examined features in non-progressors and has in several studies been found to be lower in EC as well as VC compared to progressors [70–74]. In support of the significance of low IA on lack of disease progression a study of EC revealed that the individuals with the highest IA presented with the lowest CD4+ cell counts [73] (Table 2). Also, the natural hosts of simian immunodeficiency virus (SIV), sooty mangabeys and African green monkeys, who do not progress despite a high viral load (and thus can be seen as a simian pendant to LTNP), do not show any signs of increased IA or T-cell turnover [75, 76]. IA is inadequately examined in LTNP. One study did not find any differences in IA between EC and LTNP, while they were both different from progressors [77], while another study did not find any differences between the three groups [78]. Interestingly, this latter study, one of the only studies to have compared controllers and LTNP, also evaluated the phenotypic and functional properties of CD56/CD16 natural killer (NK) cells, a major component of the innate immune system. Cytolytic activity against autologous CD4+ cells was found to be abrogated after treatment with an antibody to NKp44L, the cellular ligand of the natural cytotoxicity receptor NKp44, which is specifically induced on CD4+ T cells during HIV-1 infection, in LTNP and HIV progressors. In contrast, in HIV controllers and healthy donors, NKp44L expression on CD4+ cells and autologous NK lysis were both poorly detected [78]. This is strongly supportive of LTNP and controllers as being immunologically different.
Another component of the innate immune system that may be involved in non-progression is the plasmacytoid Dendritic Cells (pDCs). PDCs have been suggested as inducers of IA and CD4+ cell apoptosis as they recognize HIV single-stranded RNA (ssRNA) via Toll-like receptors (TLR) resulting in interferon (INF) α production [79–82]. Furthermore, polymorphisms in TLR7 and the interferon regulator 7 of INFα may influence disease progression and the ability of pDCs to produce INFα [83, 84]. In controllers, the number and function of pDCs are reported to be preserved [85]. In addition, pDCs from rhesus macaques produce large amounts of INFα when stimulated with SIV or HIV, while the natural hosts, sooty mangabeys, seem to have lower levels of INFα [86]. Altogether, this suggests pDCs to induce IA, and they may therefore be involved in non-progression of HIV infection.
IA is accompanied by apoptosis and immunological senescence, and HIV-infected patients present with elevated levels of both features [87, 88]. Senescent cells in EC and progressors have been examined in a single study, and comparable levels were found [8]. In contrast, in a study of non-progressors with unknown viral load the level of apoptosis was found to be similar to healthy controls and lower than in progressors [89], and others have reported lower levels of apoptosis in VC compared to progressors [90], both supporting the idea of a lower turnover as contributing to non-progression. However, low turnover could also simply reflect a lower IA. Contrary, another study found elevated levels of apoptotic cells in non-progressors compared to progressors [91], implying that a high turnover is beneficial. This finding makes sense, if we assume that activated cells are eliminated by apoptosis. Then an increasing proportion of apoptotic cells eliminate the harmful IA, thereby diminishing disease progression. Either way, evidence is lacking, and whether a high turnover of cells is contributing to non-progression is still to be determined.
Thus, it seems reasonable to assume that the level of IA is a determinant for how fast the turnover of T cells is, thereby relating IA to exhaustion (Table 2). Indeed, it has been proposed that IA leads to CD4+ cell depletion because it erodes the naïve T-cell pool [92]. Still, the reason for the strong predictive value of IA in HIV infection is uncertain, but low IA found in controllers suggests that IA forms an important role in lack of progression.
The understanding of the immune system is constantly changing as a consequence of rapidly expanding knowledge. Recently, the discovery of T-cell subsets with pro- and anti-inflammatory properties has altered our view on immunology. Regulatory T cells (Tregs) are anti-inflammatory T cells, while Th17 cells have proinflammatory properties. Tregs are crucial in sustaining tolerance to self-antigens [93, 94] and suppressing T-cell activation resulting in down-regulation of immune activation, including reduction in anti-tumor immunity, graft rejection, and graft versus host disease ([95], reviewed in [96]). Finally, the role of Tregs in chronic viral infections, including HIV, has gained considerable interest due to their immunosuppressive capabilities. Thus, in theory, Tregs can downregulate the chronic IA seen in HIV infection making Tregs a key element in the understanding of the interaction between the host immune system and HIV (reviewed in [97]). For this reason, Tregs have been suggested as downregulators of the unbeneficial unspecific IA in HIV-infection, expecting high levels of Tregs as being an advantage. However, levels of Tregs in HIV-infected, untreated, progressing patients have been shown to be elevated compared to healthy controls in a number of studies ([98–100] reviewed in [101]). This suggests that high levels of Tregs are actually harmful, possibly because they downregulate beneficial HIV-specific responses. In support of this, the level of Tregs in controllers has been reported to be lower compared to progressors, and closer to healthy controls, although conflicting results have been reported as well [70, 77, 102–106]. Furthermore, it has been shown that the suppressive activity of Tregs in EC is preserved, while it was found to be disrupted in progressors [105]. Finally, Tregs have been suggested to increase with age (reviewed in [107]), possibly contributing to the reported loss of non-progression in some individuals. All together this is supportive of a significant influence of Tregs on non-progression.
However, like most other pieces in the puzzle of understanding the interaction of HIV and the immune system the Treg element has proven to be more complex than expected. Thus, Tregs are closely related to IL-17-producing Th17 cells. Tregs and Th17 cells share a reciprocal maturation pathway and function together in opposing ways to control the inflammatory response upon infection. While Tregs inhibit autoimmunity, Th17 cells have been shown to play a critical role in the induction of autoimmune tissue injury and immune responses [108]. Th17 cells have been shown to be rapidly depleted during acute SIV infection cells, and a disturbed balance of Th17 cells and Tregs has been suggested to be associated with subsequent high IA and disease progression ([109, 110], reviewed in [101, 111]). In controllers, a maintained balance between Tregs and Th17 cells is reported [102] (reviewed in [112]), highlighting the significance of a well-regulated balance between Tregs and Th17 cells. Th17 cells and Tregs have primarily been examined in controllers. However, one study of a group of non-progressors, where most participants met the LTNP criteria, have found elevated levels of Th17 cells compared to progressors [113]. Thus, a high level of Th17 cells may contribute to lack of progression in controllers as well as in LTNP. However, HIV leads to redistribution of CD4+ cells between blood and lymphatic tissue (LT). Thus, it has been demonstrated that HIV binds to resting CD4+ cells and upregulates L-selectin causing the cells to home from the blood into lymph nodes (LNs) at enhanced rates [114, 115]. This has led to the homing theory, offering an explanation for the loss of CD4+ cells due to cells leaving the blood and entering the LT (reviewed in [116]). Indeed, accumulation of Tregs has been found in secondary lymphatic tissue (SLT) compared to peripheral blood in untreated HIV-infected patients [117, 118], indicating that the conclusion drawn from the reported findings of Tregs in peripheral blood is to be considered with caution.
CD4+ cell depletion occurs in the blood as well as in the SLT of LN and gut-associated lymphatic tissue (GALT) where the majority of the CD4+ cells reside. During primary HIV infection a vast number of cells are depleted, reaching a loss of more than 50% in LN as chronic infection is established [119, 120]. It has been proposed that HIV damages the structures in the LT, that help sustain the normal CD4+ cell population replacing the functional space with collagen. Thus, the greater the amount of the collagen deposition, the lower the CD4+ cell count and the smaller the number of naive CD4+ cells [121]. Also, LN biopsies from HIV- and SIV-infected individuals show breakdown of the lymph node architecture and evidence of apoptosis [122]. In contrast, a preserved lymph-node architecture was reported in the history of HIV in non-progressors compared to progressors, indicating that progressors host a preserved SLT [123]. GALT is the main defence against infectious microorganisms in the gastrointestinal (GI) tract and consists largely of T cells. Importantly, the main part of Th17 cells reside in the GALT [124]. Th17 cells are important for the integrity of the gut mucosal barrier by stimulating epithelial proliferation and inducing a proinflammatory environment by recruiting neutrophils to fight microorganisms. Upon acute HIV infection follows a significant depletion of CD4+ cells in the GALT [125, 126]. The depletion is linked to a damage of the mucosal barrier that may be due to an imbalance of Th17 cells as the massive depletion of CD4+ cells during acute HIV and SIV infection in particular includes Th17 cells [125, 126]. The damage to the mucosal barrier results in microbial translocation (MT)—a continuing leak of microbial remnants from the GI tract that enters the systemic circulation. These microbial products lead to immune activation [111, 127, 128], thereby contributing to HIV progression. The data on mucosal integrity and the influence of MT on immune activation in non-progressors are limited. One study using a rhesus macaque model has shown that spontaneous restoration of mucosal CD4+ cells upon acute SIV infection is predictive of non-progression [129]. Furthermore, EC and VC present with similar preserved numbers of CD4+ cells in rectal biopsies comparable to HIV-negative individuals, while the number in progressors is reported to be diminished [130, 131]. However, the level of lipopolysaccharide (LPS) used as a marker of MT is comparable in controllers and progressors and elevated compared to HIV-negative individuals [73], indicating that low chronic immune activation in non-progressors might have effect in the long-term despite the appearance of the relatively intact mucosal barrier. Thus, present data indicate that non-progressors are distinct from progressors in several aspects of the integrity of the mucosal barrier and MT, suggesting an important mechanism for the capability of non-progressors to control immune activation and HIV infection. However, to determine the causal relationship between MT and control of HIV infection prospective studies are needed.
HIV-specific CD8+ and CD4+ cells and neutralizing antibodies are considered an important albeit most often insufficient element in suppressing viral replication (reviewed in [132, 133]). Some of the first studies were made of HIV-infected patients with primary infection. Here it was shown that the level of HIV-specific CD8+ cells paralleled the efficiency of control of primary viremia. Also, patients who mounted strong gp160-specific CD8+ cell responses showed rapid reduction of acute plasma viremia, while viremia in patients with low virus specific CD8+ cell activity was poorly controlled [134]. Another study showed that an absent HIV-specific CD8+ cell response during primary HIV infection was associated with prolonged symptoms, persistent viremia, and low CD4+ T-cell count [135]. Furthermore, it has been shown that in vivo depletion of CD8+ cells eliminates the ability to contain SIV replication [136]. For this reason an HIV-specific CD8+ cell immune response is widely accepted as a contributor to control of viral replication and lack of progression in non-progressors, and this has been evaluated in a number of studies. Thus, it has been shown that non-progressors are able to maintain an established CD8+ cell precursor pool and present with a consistent highly functional HIV-specific response, while this ability is lost in progressors [137, 138]. Also, the capacity of virus-specific CD8+ cells to proliferate in response to stimulation with HIV antigens is reported to be preserved only in non-progressors [139]. This is in agreement with findings from a prospective study of an increase in polyfunctionality in HIV-specific CD8+ cell responses from EC, and a decrease in progressors over time [140], and with findings of a stronger and broader cytokine and chemokine response following HIV-specific stimulation of PBMC from EC compared to progressors [70, 77]. In addition, it has been reported that the inhibitory immunoregulatory receptor CTLA-4 is selectively upregulated in HIV-specific CD4+ cells in progressors compared to non-progressors. CTLA-4 expression was also found to be positive associated with disease progression and negatively associated with the capacity of CD4+ cells to produce IL-2 in response to viral antigen [141]. Furthermore, it has been shown that in non-progressors HIV-specific CD8+ T cells efficiently eliminate primary autologous HIV-infected CD4+ cells [142]. Additionally, it seems of importance if the HIV-specific cells are activated or not, as it has been shown that ECs possess lower levels of activated HIV-specific CD8+ cells and of recently divided HIV-specific CD4+ cells than progressors [70]. Based on these data an ideal HIV vaccine would induce strong HIV-specific immune responses and minimize HIV-specific immune activation. Another goal of vaccine development is induction of antibodies that neutralize a broad range of HIV isolates. Although antibodies can be elicited by HIV infection, those that are broadly neutralizing are undetectable in most individuals (reviewed in [143]). The level and the breadth of neutralizing antibodies are reported to correlate to viral load [144, 145], and the same or lower levels of antibodies are reported in controllers compared to progressors [144, 146]. Furthermore, one study showed that no single anti-HIV antibody specificity was a clear correlate of immunity in controllers [146]. This is consistent with neutralizing antibodies as poor contributors to non-progression. Contrary, antibodies directed against autologous Env variants are reported to be present in non-progressors [147], and efficient elicitation of de novo neutralizing antibodies has been shown in SIV controllers [148].
Taken together these findings unanimously indicate that a virus-specific response by CD8+ cells is a contributing factor to non-progression, while the influence of virus-specific CD4+ cells and neutralizing antibodies is more unclear. Interestingly, similar preserved HIV-specific T-cell responses have been demonstrated in a study of controllers and LTNPs while responses were blunted in progressors [149]. This indicates that HIV-specific responses are crucial in sustaining non-progression, regardless the viral replication, consequently playing a role in non-progression in controllers as well as in LTNP. However, these beneficial HIV-specific responses might be a part of the explanation of why HIV is not being eradicated, even in controllers. Thus, it has recently been shown that high HIV-specific responses are associated with high levels of cell-associated HIV DNA levels in controllers [150].
Despite effective cART complete eradication of HIV seems unlikely, and complete eradication of HIV is so far only obtained once in the Berlin-patient [30]. In general, low-level HIV replication continues despite cART. This is in part due to the capability of HIV to conceal itself and persist in cellular reservoirs. Furthermore, a major impediment to the eradication of HIV is latently infected resting CD4+ cells that are characterized by proviral DNA integration into the host genome; particulary memory CD4+ cells have proven to be a major cellular reservoir for HIV [151]. The major anatomical site for HIV reservoir is SLT including GALT [152–154]. Thus, viral reservoirs are considered a major obstacle to eradicate HIV and considered to be the reason for rebound viraemia during cART interruptions. Notably, the concept of a functional cure has emerged where lifelong control of viral replication is obtained and disease progression is avoided although provirus is detectable. This might be illustrated by the viral control found EC.
Few studies have examined the capability of non-progressors to eradicate or reduce HIV reservoirs and latency. However, low proviral DNA in PBMC in EC compared to patients on cART has been demonstrated [155, 156]. One study even reported differences in the level of proviral loads in EC compared to VC, implying that even low viral replication is of importance [17]. Furthermore, autologous viral replication ex vivo was detected in only 2 out of 14 EC compared to 9 out of 10 VCs, suggesting ECs to have a diminished viral reservoir in peripheral CD4+ cell compartment [17]. Furthermore, impaired viral replication in the early phase of HIV seems to be predictive for VC [157]. The anatomical reservoir in GALT has been examined in a small study revealing lower levels of HIV DNA in rectal tissue in LTNP compared to progressors [158]. However, an SIV macaque model demonstrated that colon mucosa and associated lymph nodes are a major SIV reservoir even in controllers [159].
Conclusively, non-progressors and especially EC seem to have diminished cellular reservoirs, whereas the size of the anatomical viral reservoirs in SLT is uncertain. However, the described traffic of CD4+ cells between plasma and SLT and the reduced microbial translocation indicate that non-progressors harbor a lower viral reservoir in SLT than do progressors. Understanding how ECs control and reduce cellular reservoir might provide the basis to elucidate the needs for a functional cure.
A common feature in non-progressors is preserved immunology. However, reports of loss of the non-progressor status with declining CD4+ cell counts in LTNP have been observed, and these patients may eventually require cART. Likewise, a loss of viral control in controllers is reported. Interestingly, progression and AIDS events in controllers despite low or undetectable viral loads events are reported as well [2, 8, 22, 29, 39, 48, 73, 160]. As a result of this, cART has been suggested to controllers.
In EC viral replication cannot be measured in commercial assays in EC. However, using ultrasensitive assays HIV RNA can be detected in the majority of these patients [161, 162], and it has been shown that loss of CD4+ cells is more common among ECs with low level viremia [162]. Furthermore, low-level viremia is reported to be associated with measurable T cell dysfunction in EC [163]. Finally, is has been shown that blips are associated with a nonfavourable clinical outcome [26]. Taken together, this indicates that even very low levels of viremia have clinical implications and are involved in disease progression. This is supported by findings of higher levels of immune activation in controllers compared to patients on cART [73, 164]. Moreover, it seems plausible that cART would normalize immunological parameters in controllers. This is confirmed by findings of declining immune activation in EC and increasing CD4+ cell counts in EC as well as EC as due to cART initiation [165, 166]. Thus, cART may be considered in progressing controllers despite undetectable viral replication.
Rare groups of HIV-infected patients that do not progress to AIDS or death have been known since the beginning of the HIV epidemic. Some of these non-progressors control viral replication, that is, the controllers, while LTNP, have ongoing viral replication. So far, it is not clear why these patients do not progress, but immunological mechanisms have been suggested. The immunological response to HIV infection can be divided into an immune homeostasis resistant to HIV and an immune response leading to viral control. This paper has focused on immunology in non-progressors. We suggest that two different mechanisms are responsible for preserved CD4+ cell counts in controllers and LTNP.
In summary, data unambiguously show that controllers are immunologically different from progressors in production, destruction, and regulation of cells. Thus, controllers have a preserved CD4+ cell production with a bone marrow function, a lymphopoiesis, a thymic output, and an IL-7/IL7-R balance resembling HIV-negative individuals. Furthermore, controllers have lower destruction of CD4+ cells as evidenced by lower microbial translocation, immune activation, and apoptosis. Likewise, the balance between Tregs and Th17 cells is less disturbed and HIV reservoirs seem to be lower compared to progressors. However, non-progression and preserved CD4+ cells counts in controllers may not be entirely surprising since they are characterized by viral control and thus to be compared with HIV-infected patients on treatment. Thus, preserved immune homeostasis may be a reflection of rather than a reason for the viral control. In contrast, high level of HIV-specific immune response in controllers is probably a contributing factor to non-progression in controllers.
The really intriguing question is how non-progression occurs in LTNP where continuous viral replication is evident and ought to result in destruction of CD4+ cells. Unfortunately, the literature of LTNP is limited, often because they are included in study populations of controllers as viral load is not included in the definitions. An extraordinary ability to produce cells or a lower rate of destruction is expected in these patients according to the preservation of normal CD4+ cell counts. However, increased rate of production has not been shown so far, and the finding of similar levels of IL-7 between LTNP and progressors suggests that a different CD4+ production is not the explanation for non-progression in LTNP. Likewise, evidence of reduced turnover of cells in LTNP has not been found, and in general LTNPs appear to have an immune system very much like progressors. However, findings of elevated levels of Th17 cells have been reported, suggesting that the immune regulation by pro- and anti-inflammatory cells is different in LTNP compared to progressors. Indeed, it would be interesting to further evaluate immunological parameters, includingTh17 cells, Tregs, and microbial translocation in LTNP, ideally in prospective studies in order to clarify cause and effect. Also, it would be of interest to elucidate immunological parameters in former LTNP who have lost their non-progressor status.
Finally, due to distinct immunologically profiles in LTNP and controllers, we suggest that a clear distinction between patients with and without viral replication is made in future studies in order to improve the possibility to understand the different mechanisms for non-progression in these fascinating patients.
The authors have no conflicts to disclose.
The authors thank the Novo Nordisk Foundation and University of Copenhagen for financial support.
PubMed Central Canada is a service of the Canadian Institutes of Health Research (CIHR) working in partnership with the National Research Council's national science library in cooperation with the National Center for Biotechnology Information at the U.S. National Library of Medicine(NCBI/NLM). It includes content provided to the PubMed Central International archive by participating publishers.


text:
E.D. White Key Club wins international contest
Published: Tuesday, July 31, 2007 at 10:28 a.m.
Last Modified: Tuesday, July 31, 2007 at 10:51 a.m.
THIBODAUX -- A strong, schoolwide emphasis on community service was behind E.D. White Catholic High Key Clubs unprecedented showing this month at an international convention, where the local service group won a slew of awards and took home two of the competitions highest honors.
Out of six categories judged, the Thibodaux high-schoolers earned honors in five, competing in Orlando, Fla., against clubs from 23 countries. Among the individual and group awards were first-place showings in the scrapbook contest, a second-place award for hosting a health fair to combat childhood obesity and a recruitment video that won third-place among the assembled service clubs.
"We were the most recognized, the most honored, in the whole international" convention, said Scott Dupont, an E.D. White teacher and coach who served as the clubs adviser until his appointment earlier this month as the Key Club administrator for the entire Louisiana-Mississippi-Tennessee area.
"Thats an amazing feat," Dupont said. "We were optimistic, we just didnt dream that we would do that well."
The icing on the cake was a first-place finish in the "Single Service" category, which recognizes the best Key Club service project of the year.
More than 100 E.D. White Key Club members spent nearly four months working on a labor-intensive refurbishment of the playground at the Peltier-Lawless Development Center, a special-education school in Thibodaux.
"Basically we just gave it a big face-lift," Dupont said. "Our kids were really great. They embraced the project."
The students also raised money to buy a wheelchair-accessible swing, which cost $4,000, and logged dozens of hours planting shrubs, grass and flowers to beautify the playground.
David Cavell, an 18-year-old E.D. White graduate who took part in the project, said the recognition is secondary to the appreciation of the neighbors and children who will be able to take advantage of the clubs work.
"It was just overwhelming to see the satisfaction on the peoples faces after we were done," said Cavell, who starts his freshman year at Southeastern Louisiana University this fall.
Dupont was a member of the E.D. White Key Club as a student and began serving as the club adviser when he returned to his alma mater to teach chemistry and coach softball.
The clubs bevy of awards "is the best ever for our school," Dupont said.
At E.D. White, Dupont said, the Key Club is a natural extension of the schools requirement that all students perform community-service projects.
"Service is a way of life for us," Dupont said.
The club, which has been at E.D. White for more than 30 years, owes its most-recent success to the hundreds of service-minded members who have passed through the school, he added.
"Weve had wonderful students who have come through our club," Dupont said. "I think many would come back and say Key Club shaped their work ethic and desire to help their community."
Staff Writer Robert Zullo can be reached at 850-1150 or firstname.lastname@example.com.
Reader comments posted to this article may be published in our print edition. All rights reserved. This copyrighted material may not be re-published without permission. Links are encouraged.
Comments are currently unavailable on this article


text:
Calcium Chloride
International Thalassemia Awareness »
"Did you know that beta thalassemia major, the most severe form of thalassemia, affects about 1,000 people in the United States? By staying committed to long-term treatment, people with thalassemia can enjoy a full life.
Thalassemia is a g"...
Calcium Chloride Injection 10%
Calcium is the fifth most abundant element in the body; the major fraction is in bone. It is essential for the functional integrity of the nervous and muscular systems, for normal cardiac contractility and the coagulation of blood. It also functions as an enzyme cofactor and affects the secretory activity of endocrine and exocrine glands.
Last reviewed on RxList: 9/30/2008
This monograph has been modified to include the generic and brand name in many instances.
Calcium Chloride Injection 10% FDA Prescribing Information
Additional Calcium Chloride Injection 10% Information
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Women's Health
Find out what women really need.


text: I am new to wordpress and have encountered a problem with my installation. I have everything set up, I go to my login page for my site (www.hookedontennis.com) and after I log in all I get is a blank white page. I have scoured the internet and it seems like this white page has been a problem for people for numerous reasons. I just havent been able to find a solution that works for me. Any help would really be appreciated. Thanks!


text:
Quick Contact
B. P. Chemicals
Address :
714, Kayasthwara, Rewari, Haryana, India
Mobile No. :
+91-9416582888, +91-9416063123
Phone No. :
+91-1274-255257, +91-1274-256257
Fax :
Call Us :
We are listed at the apex in the list of the reliable Hydrated Sodium Borate Suppliers in Rewari, Haryana. The Borax Powder, offered by us, is widely demanded in the market as no alternative is available in terms of purity and fine particle size. We have earned loads of appreciation by our clients for providing Wholesale Borax at the most profitable deals. Additionally, we provide Borax Powder conventionally packed in 50 Kg Polyethylene Lined HDPE / HESSAIN Bags.


text:
Register now for Summer 2016! Early registration gives you first access to scholarships, spots on the program, and prizes! Visit www.ncsysummer.com to check out the various programs and sign up now!!!
Follow @NCSYSeattle
Copyright © 2016 · All Rights Reserved · Seattle NCSY
Bold Theme by Organic Themes · RSS Feed · Log in


text:
Note: If you are an Amateur Radio Operator, please include your call sign in the 'Additional Comments' field directly above.
Within the next few hours you will receive your registration code from Dog Park Software Ltd.
Having trouble? Call (510) 658-5244, Monday thru Friday between 9:00 a.m. and 5:00 p.m. Pacific Time. (Store Code: XOB)


text:
"Athletic" modelling
Bryan is approached to do some modelling, and leads him to try a lot more....
"Hey man, whatcha doin'?" (HMW)
...before stopping at the base, squeezing hard, before he resumes his gliding, back up its length. After traveling the full length of my tool, one time, he spreads the discharged juice he pumped from my inner most depths across the mushroomed head of my cock. I hear myself, gasp, at the sensitivity of my member. "That's a nice seepage of juice, you got there, bud," Keaton says to me.
"You need help with this?" I ask as I roughly grab his cock, catching him, unawares, while gently stroking mine as I gaze up at him. I squeeze him, tight, his hard equipment, pulses in my grip. It seduces me with it appealing stiffness between his still wet and water-soaked legs.
"The Gift," Part 1
Denny returns to school to land a new job after being 'downsized,' but discovers that college has changed since he earned his first degree.
"The Gift," Part 2
Denny and Liam get down to business, and pleasure. But what's up with the restrooms at the college?
"The Gift," Part 3
Can Denny balance Liam and Anthony, his college classes, and rescuing a vulnerable lad?
"The Gift," Part 4
Denny discovers secrets about Hal's past, and explores his future with Anthony.
"The Gift," Part 5
Denny finds himself in the middle when Anthony and Liam almost come to blows, and later he discovers even more horrible secrets about Hal and Doc.
"The Gift," Part 6
How will Denny get Hal out of this mess?
"The Gift," Part 7
four guys under a time deadline to perform, so that they can pass the class run by a sadistic professor. Will they succeed?
"The Gift," Part 8
A grocery store, sex, and a video camera. A recipe for disaster, or freedom? Hal and Doc's lives are about to change.
"Therapy," Chapter 1
Jess is stuck in an abusive relationship with the rugby team captain, Brayden. Until he meets Demetriou, a god of a man.
1st Adult Bookstore Arcade Experience
True recalling of my 1st encounter at an arcade in Memphis, Tennessee
1st Time fucked a Boy-pussy
My Introduction to the gay world through my elder cousin brother
2 Best Friends First Time
True story-2 best friends take their friendship even further one day.
2nd Time With Same Guy?
This is like pt2 of my other story "it's weird how it happened" a user requested to tell us more so this is pt2.....
A Burglar at My Back Door
His virginity is taken by an intruder.
A Camping Trip to Remember
We all have first time experiences; mine happened with my best friend at the time.
A Change of Hearts
James finally comes to terms with what has happened.
A Cherry Tale
Let me tell you about the first time I fucked another man. We'd been dating a couple of weeks and I really wanted in his pants badly. His name was Tom.
A Christmas Miracle - Jimmy and Jesse
Jimmy's lived in solitude for a long time, finding anonymous sex when he couldn't stand it any longer and had to have it, keeping himself safe from ever getting hurt again. Not from his family who disowned him when he came out, not from boyfriends, the last of which did an epic number on him. But Jesse doesn't wait any longer, and one Christmas night when they are both volunteering at the shelter, he brings Joy to Jimmy.
A Crazy Trip to Camp
I had always thought I was straight until I had this night of wild sex with two guys. It was an amazing night and it changed my life for the better!!
A Cumming Out Of A Sort
We got to the club and immediately went to the dance floor, shedding our coats on the way. The floor was packed with writhing bodies and we joined in the festivities with abandon, not knowing whom we danced with and caring even less.
A Cursed Life
I was really getting used to the fact of seemingly living a cursed life, Nothing was going the way I had planned, But even then, Was it all that bad?
A Dad's Secret
Being a single parent isn't easy, especially with the dad is only fifteen years older that the son. That's the case with me.
A Dad's Secret - Part 2
Unknown to Clint, his son, Luke, sees him and Jack in a sixty-nine on the secret monitors.
A day at the Dog Park
My first hook up with a guy. I met him from an online ad. I was 18, he was 48.
A Dinner With Friends Turns Into Dirty Story Time
Sitting around with friends the other night at dinner, we got on the subject of "first times". At my husband's urging I told a rarely-told truth of my sexual reawakening at a very young age. It turned into a rowdy, inappropriate funtime . . . as so many with a bunch of bromos do.
A Dream Just Came True
A close friend of my daughters just lost his home due to a divorce of his parents, I rented a room to him.
A fantasy come true
An experiance I would like to repeat!!!


text:
Send Tina a message explaining your needs and you will receive a response shortly. Have you already emailed Tina or another tutor? If so, you have an account! Sign in now
If you select this option, WyzAnt will ask interested tutors to contact you by email if they are able to help. A maximum of five different tutors will email you and none of your personal information, including your email address, will be released.
UC Irvine
My name is Tina and I am a graduate from UC Irvine with a Biology degree.
I am a native Mandarin speaker from Taiwan available to teach my the language to anyone has an interest in learning it. I can help students of all levels with grammar, vocabulary, pronunciation and daily conversation.
I have had individual and group tutor experiences. I am a fun-loving, caring and compassionate person so that is the way I conduct my classes. I bring different activities to my classes so my students can learn the language more effectively. My ultimate goal is to see my students achieve the language skill as well as learning the culture.
Thank you for reading about me and I look forward to speaking to you. Hello,
My name is Tina and I am a graduate from UC Irvine with a Biology degree.
I am a native Mandarin speaker from Taiwan available to teach my the … Read more
The hourly rate is for one on one session. Please contact me for group rates.
Tina is a very patient and extremely approachable tutor for my 6 year old daughter. I have had a couple of Mandarin tutors for myself and listening in on her lessons with my daughter, really proves to me, what I was missing with my tutors. When teaching, she speaks slowly in Mandarin, so it is manageable and not intimidating for my daughter (and myself) to understand. She has well thought-out lesson plans, that are age appropriate and fun. It is apparent by her teaching style and lesson plans that she enjoys what she does. I highly recommend Tina as a tutor for any age.
Approved subjects are in bold.
In most cases, tutors gain approval in a subject by passing a proficiency exam. For some subject areas, like music and art, tutors submit written requests to demonstrate their proficiency to potential students. If a tutor is interested but not yet approved in a subject, the subject will appear in non-bold font. Tutors need to be approved in a subject prior to beginning lessons.
I was born and raised in Taiwan, and Chinese Mandarin is my first language. Having living in the US for more than 20 years, I am also fluent in English. This will help me to teach the culture and the language to anyone who wants to learn Mandarin. I have had experiences in teaching children Mandarin. I am friendly and patient. I trust I will offer an interesting learning experience to those who want to learn Mandarin.
Have fun and learn Mandarin effectively


text:
- Other Operating Systems (16)
- Linux (14)
- Modern (13)
- Grouping and Descriptive Categories (10)
- Solaris (10)
- Mac (9)
- Windows (9)
Top Apps
- Audio & Video
- Business & Enterprise
- Communications
- Development
- Home & Education
- Games
- Graphics
- Science & Engineering
- Security & Utilities
- System Administration
A powerful, cross platform, SQL database system25,930 weekly downloads
SW Test Automation Framework
The Software Testing Automation Framework (STAF) is a framework designed to improve the level of reuse and automation in test cases and test environments. The goal of STAF is to provide a complete end-to-end automation solution for testers.845 weekly downloads
JobScheduler workload automation to execute jobs and job chains578 weekly downloads
yaSSL, or yet another SSL, is an embedded ssl library for programmers building security functionality into their applications and devices. yaSSL is highly portable, and runs on standard as well as embedded platforms(QNX, ThreadX, VxWorks, Tron) yaSSL is still available but no longer being developed. Current development on the same project continues under wolfSSL. Visit yaSSL Home above for the latest stable release.4 weekly downloads
SAXP - Streaming API For XML Parsing
Implementation of JSR 173 - Streaming API For XML (http://www.jcp.org/en/jsr/detail?id=173). This effort is taken in consideration of Axis C project and now it has impl. as an internal component.3 weekly downloads
Real time micro benchmark suite
Real time micro benchmark multi-lingual suite (RTMB) provides a good way to measure the deterministic quality of hardware, an operating system, or a Java Virtual Machine. RTMB consists of benchmarks in C, C++ and Java8 weekly downloads
Concurrent Building Block
Project provides a set of concurrent building blocks (Java & C/C++) that can be used to develop parallel/multi-threaded applications. Components are grouped into 4 categories: 1.Data Structures 2. Parallel Patterns 3.Parallel functions 4.Atomics and STM6 weekly downloads
Java FTP for Integration
JFTP4I is a Java FTP Framework that dinamically calls an user implemented class on each client request. When the user makes a request to a file, the framework automatically uses the configuration XMLs to start an event to deal with the data requested.1 weekly downloads
Microscopy Image Processing Package
XMIPP is an image processing suite for 3D-reconstruction of biological specimens from transmission electron microscopy data. NOTE that stable releases (including binaries) are longer stored at Sourceforge, but are available at http://xmipp.cnb.csic.es1 weekly downloads
The XE Toolkit
The XE Toolkit is a multi-platform, network-aware, secure performance monitoring solution for tactical analysis of enterprise computing systems.1 weekly downloads
Extended Oracle Toosl
Microstream is a open platform with open architecture and open functionality to build up information systems .
NFS Wing
NFS-Wing is an Proposed File Sharing Mechanism on an single server based environment. Clients interact with the Server for NFS Protocol operations. This is an two tier archietecture where in Remotely added content will reflect in the NFS Filesystem.
Portal Logic
Portal Logic(Deamon) Basically Functions as a Service Replay System in distributed environment. It is generically coded to perform Service based protocol translation, where in an cluster for example could interact with the deamon for Service Request.
XLib for db2 udb
extend what db2 can do. developer and dba helper.
AI simulation of human life and behavior, based on LINUX architecture.