text:
Michael Y. Sherman
Boston University School of Medicine
Silvio Conte Building
72 E. Concord Street
Boston, MA 02118
Phone: (617) 638-5971
Lab Phone: (617)638-5970
Fax: (617) 638-5339
Email: firstname.lastname@example.com
PhD, Moscow University, Russia
|Vladimir Gabai
Research Asst. Professor
| Julia Yaglom
Research Asst. Professor
|Anatoli Meriin
Research Interests
I. Research in my lab has focused on understanding the molecular mechanisms underlying the central role of the heat shock protein Hsp72 in cancer. In cancer cells Hsp72 is often expressed at very high levels, and its expression correlates with the aggressiveness of tumors. Recently we have found that Hsp72 regulates early stages of tumorigenesis. Indeed, Hsp72 can control signaling pathways initiated by major oncogenes, resulting in avoiding growth inhibition and facilitating cell proliferation and transformation.
Our research addresses several questions:
(1) How Hsp72 keeps the p53 pathway activated by PIK3CA oncogene under control?
(2) How Hsp72 prevents cell senescence activated by Her2 oncogene.
II. In a distinct project we study a process of aggregation of abnormal polypeptides. When chaperone and protein degradation machineries fail to handle abnormal proteins, they aggregate and cause cell toxicity, which may give rise to various neurological disorders. As the last line of defense, a special machinery has evolved that transports these toxic aggregates to a centrosome location via microtubules, which leads to relieve of toxicity. The resulting non-toxic single large aggregate is called aggresome. Previously we have established a yeast model to study aggregation and toxicity of the disease-causing polypeptides with expanded polyglutamine domain. Now, using both yeast and mammalian systems, we are dissecting the pathway of aggresome formation.
Our current research within this project uses genetics and biochemical approaches to addresses the following questions:
(1) What cellular components are involved in aggresome formation?
(2) What signaling pathways control aggresome formation?
Research Themes
Representative Publications
- Zaarur N, Xu X, Lestienne P, Meriin AB, McComb M, Costello CE, Newnam GP, Ganti R, Romanova NV, Shanmugasundaram M, Silva ST, Bandeiras TM, Matias PM, Lobachev KS, Lednev IK, Chernoff YO, Sherman MY. RuvbL1 and RuvbL2 enhance aggresome formation and disaggregate amyloid fibrils. EMBO J. 2015 Sep 14; 34(18):2363-82. PubMed
- Sabbieti MG, Agas D, Capitani M, Marchetti L, Concetti A, Vullo C, Catone G, Gabai V, Shifrin V, Sherman MY, Shneider A, Venanzi FM. Plasmid DNA-coding p62 as a bone effective anti-inflammatory/anabolic agent. Oncotarget. 2015 Feb 28; 6(6):3590-9. PubMed
- Gong J, Weng D, Eguchi T, Murshid A, Sherman MY, Song B, Calderwood SK. Targeting the hsp70 gene delays mammary tumor initiation and inhibits tumor cell metastasis. Oncogene. 2015 Oct; 34(43):5460-71. PubMed
- Li X, Colvin T, Rauch JN, Acosta-Alvear D, Kampmann M, Dunyak B, Hann B, Aftab BT, Murnane M, Cho M, Walter P, Weissman JS, Sherman MY, Gestwicki JE. Validation of the hsp70-bag3 protein-protein interaction as a potential therapeutic target in cancer. Mol Cancer Ther. 2015 Mar; 14(3):642-8. PubMed
- Gabai V, Venanzi FM, Bagashova E, Rud O, Mariotti F, Vullo C, Catone G, Sherman MY, Concetti A, Chursov A, Latanova A, Shcherbinina V, Shifrin V, Shneider A. Pilot study of p62 DNA vaccine in dogs with mammary tumors. Oncotarget. 2014 Dec 30; 5(24):12803-10. PubMed
- Sherman MY, Gabai VL. Hsp70 in cancer: back to the future. Oncogene. 2015 Aug 6; 34(32):4153-61. PubMed
- Yaglom JA, McFarland C, Mirny L, Sherman MY. Oncogene-triggered suppression of DNA repair leads to DNA instability in cancer. Oncotarget. 2014 Sep 30; 5(18):8367-78. PubMed
- Colvin TA, Gabai VL, Gong J, Calderwood SK, Li H, Gummuluru S, Matchuk ON, Smirnova SG, Orlova NV, Zamulaeva IA, Garcia-Marcos M, Li X, Young ZT, Rauch JN, Gestwicki JE, Takayama S, Sherman MY. Hsp70-Bag3 interactions regulate cancer-related signaling networks. Cancer Res. 2014 Sep 1; 74(17):4731-40. PubMed
- Proteotoxicity is not the reason for the dependence of cancer cells on the major chaperone Hsp70. Colvin TA, Gabai VL, Sherman MY. Cell Cycle. 2014 Jun 9;13(14).
- Proteasome failure promotes positioning of lysosomes around the aggresome via local block of microtubule-dependent transport. Zaarur N, Meriin AB, Bejarano E, Xu X, Gabai VL, Cuervo AM, Sherman MY. Mol Cell Biol. 2014 Apr;34(7):1336-48.
- Less is more: improving proteostasis by translation slow down. Sherman MY, Qian SB. Trends Biochem Sci. 2013 Dec;38(12):585-91.
- ΔNp63α regulates Erk signaling via MKP3 to inhibit cancer metastasis. Bergholz J, Zhang Y, Wu J, Meng L, Walsh EM, Rai A, Sherman MY, Jim Xiao ZX. Oncogene. 2012 Dec 17. doi: 10.1038/onc.2012.564. [Epub ahead of print]
- Molecular determinants of selective clearance of protein inclusions by autophagy. Wong E, Bejarano E, Rakshit M, Lee K, Hanson HH, Zaarur N, Phillips GR, Sherman MY, Cuervo AM. Nat Commun. 2012;3:1240.
- A novel approach to recovery of function of mutant proteins by slowing down translation. Meriin AB, Mense M, Colbert JD, Liang F, Bihler H, Zaarur N, Rock KL, Sherman MY. J Biol Chem. 2012 Oct 5;287(41):34264-72. doi: 10.1074/jbc.M112.397307. Epub 2012 Aug 17.
- Polyglutamine toxicity is controlled by prion composition and gene dosage in yeast. Gong H, Romanova NV, Allen KD, Chandramowlishwaran P, Gokhale K, Newnam GP, Mieczkowski P, Sherman MY, Chernoff YO. PLoS Genet. 2012;8(4):e1002634. doi: 10.1371/journal.pgen.1002634. Epub 2012 Apr 19.
- The heat shock transcription factor Hsf1 is downregulated in DNA damage-associated senescence, contributing to the maintenance of senescence phenotype. Kim G, Meriin AB, Gabai VL, Christians E, Benjamin I, Wilson A, Wolozin B, Sherman MY. Aging Cell. 2012 Aug;11(4):617-27. doi: 10.1111/j.1474-9726.2012.00827.x. Epub 2012 May 22.
- Association of translation factor eEF1A with defective ribosomal products generates a signal for aggresome formation. Meriin AB, Zaarur N, Sherman MY. J Cell Sci. 2012 Jun 1;125(Pt 11):2665-74. doi: 10.1242/jcs.098954. Epub 2012 Feb 22.
- Gabai V.L., Meng L., Mills T., Benjamin I.J., and Sherman M.Y. Heat shock Transcription Factor Hsf1 is involved in tumor progression by regulating HIF-1 and RNA-binding Protein HuR. (2012) Mol.Cell Biol., 32: 929-940.
- Gong H. , Romanova N.V, Allen K.D., Chandramowlishwaran P., Gokhale K., Newnam G.P, Mieczkowski P., Sherman M.Y. and Chernoff Y.O. Polyglutamine toxicity is controlled by prion composition and gene dosage in yeast. (2012) PLOS Genetics, 8:2634.
- Sherman M.Y., Meng L., Stampfer M., Gabai V.L., and Yaglom J.A. Oncogenes induce senescence with incomplete growth arrest and suppress the DNA damage response. (2011) Aging Cell, 10:949-61.
- Sherman M.Y. Proteotoxic stress targeted therapy (PSTT). (2011) Oncotarget 2:356-7.
- Wang Z, Gall JM, Bonegio RG, Havasi A, Hunt CR, Sherman MY, Schwartz JH, Borkan SC. Induction of heat shock protein 70 inhibits ischemic renal injury. (2011) Kidney Int. 79:861-70.
- Meng L., Hunt C., Yaglom J.A., Gabai V.L., Sherman M.Y. Heat shock protein Hsp72 plays an essential role in Her2-induced mammary tumorigenesis. (2011) Oncogene. 30:2836-45.
- Meng L, Gabai V.L and Sherman M.Y. HER2-induced neoplastic transformation and tumorigenesis requires heat shock transcription factor HSF1. (2010) Oncogene, 29:5204-13
- Gabai V.L., O'Callaghan-Sunol C., Sherman M.Y. and Yaglom J.A. Genotoxic stresses fail to induce γ-H2AX in tumor cells with activated senescence signaling. (2010) Oncogene, 29:1952-62.
- Meriin A.B., Wang Y. and Sherman M.Y. Isolation of aggresomes and other large aggregates. (2010) Current protocols in Cell Biology, Chapter 3:Unit 3.38.1-9.
- Sherman M.Y. Major Heat Shock Protein Hsp72 Controls Oncogene-Induced Senescence. (2010) Ann.NY Acad. Sci., 1197:152-157.


text:
Welcome. If you or a loved one are interested in Meditation, Self Hypnosis or Deep Relaxation as a means of Stress Management and Self Improvement then you will love our innovative products.
Stress can Make You Sick! It has been reaffirmed that "Sixty to Ninety Percent of all Doctor's Office Visits are Prompted by Conditions Related to Stress."
In today's world, Stress Management is Vital to Emotional, Relational and Overall Physical Health. Stress can cause Insomnia, Hypertension, Headaches, Weight Gain, Ulcers and countless more.
Reduce Stress & Boost Health Naturally
All of our products are developed and designed by professionally trained engineers who have many years of research and practical experience.
We have a range of products from which to choose. Whether you would like to learn to relax, track relaxation or hypnosis sessions or just tune out the world and escape… we have that, and a whole lot more.
Most tend to consider Meditation and Relaxation Exercises as too difficult and time consuming. However; you can Now experience in minutes what used to take years of practice. If you Reduce Stress you will Boost your Health Naturally. Your Mind & Body needs time to be still & let go to heal.
Biofeedback and Light and Sound Meditation Mind Machines can help you quickly reach an Optimal State of Focused Relaxation… Naturally.
* Enjoy 10% Off Orders $248+ using Coupon Code: 10off249 (exceptions apply)

subset: commoncrawl


text:
Wetherbee, Amos, Vergennes, was born in Ferrisburgh, Vt., on September 27, 1818. He began his life as a farmer, a business of which he made a success. He settled in Vergennes, Vt., in 1864, and has dealt largely in land and general stock, and is also a general speculator, and is called upon largely in the settlement of estates. His grandfather was a lieutenant at the battle of Bennington, Vt.. He was married in 1842 to Mary Allen, a daughter of Solomon and Catherine P. (Cross) Allen. Amos has a family of four daughters — Nellie L., Anna C., Mary E., (who married Phelps B. Smith; they have had one child born to them, Nancy M.), and Emma L. Amos Wetherbee was a son of Joshua and Anna (Barnes) Wetherbee, who were married in Ferrisburgh Vt., in 1817. Joshua was born in New Hampshire in 1789 and died in 1861, and his wife, Anna, was born in 1799 and died in 1866. They had a family of two children born to them — Amos, born in 1818; and Emily, born in 1828. Joshua was in the War of 1812 and '14, and came to Ferrisburgh, Vt., when a boy.
Biographical Sketch of Amos Wetherbee
MLA Source Citation:Finished Round 1 Editing. Needs locations and topics in round 2. Needs index page AccessGenealogy.com. Web. 27 July 2016.
https://www.accessgenealogy.com/vermont/biographical-sketch-of-amos-wetherbee.htm- Last updated on Sep 1st, 2012
This page is part of a larger collection. Access the full collection at History of Addison County Vermont.


text:
I love to program, tinker with things and generally a curious person. My career started with developing DOS TSRs in x86 Assembler. My daily work includes programming in Delphi (Windows), Ruby on Rails (Linux) and Java (Android).
My company Hagel Technologies makes network bandwidth monitor DU Meter and other software. I sometimes write in my blog.
0 answers
1 question
~8k people reached
- Kelowna, Canada
- hageltech.com/blog
- Member for 4 years, 2 months
- 8 profile views
- Last seen May 6 '14 at 22:05
Top Posts (1) All Questions Answers | Votes Newest
12 Why is my body shaking during certain exercises? Jun 25 '12
Badges (7)
Gold —
Silver 1
Bronze 6


text:
Louisville Slugger Xeno Fastpitch Bat 2015 (-10)
NOW: $149.97 (50% off!)
Was: $299.99*
Product Information:
Generate maximum speed in the swing zone without sacrificing control using the 2015 Louisville Slugger® Xeno Fastpitch Bat. Constructed with a balanced swing weight and Pure 360 composite material in the barrel and handle, the Xeno Fastpitch Softball Bat provides superior flex and a more forgiving sweet spot. The S1iD inner aluminum disc in the barrel allows for a cleaner-sounding pop, while advanced iST technology helps eliminate sting.
Click here for additional information relating to the Manufacturer's Warranty.
NOTICE: We recommend that you receive approval from your local league before removing the wrapper from your bat.
- Two-piece 100% composite construction for superior flex and forgiveness
- Pure 360 composite handle and barrel with high-strength, lightweight graphite fibers
- S1iD barrel technology features an inner aluminum disc that allows for a more flexible barrel and cleaner-sounding pop
- iST technology maintains handle stiffness and syncs with the barrel to generate a massive sweet spot
- Balanced swing weight for ultimate control at the plate
- Xeno: the most swung bat by the top 25 college programs in the country
- Standard 7/8" handle with synthetic grip
- Louisville Slugger
Click here for additional information relating to the Manufacturer's Warranty.
NOTICE: We recommend that you receive approval from your local league before removing the wrapper from your bat.
- Drop: -10
- Barrel Diameter: 2-1/4"
- Material: Composite
- Construction: Two-Piece
- Swing Weight: Balanced
- Certification(s): 1.20 BPF (ASA, USSSA, ISA, ISF and NSA)
- Sport: Fastpitch Softball
- Manufacturer's Warranty: 1 year
- Series: Xeno
- Year: 2015
- Model: FPXN150
Country of Origin: United StatesWeb ID: 41535106
Customer Reviews:
Rated 4.8 out of 5�by 18 reviewers.
Rated 4 out of 5�by carl nice bat Good bat great price but tape was comming off bat a little dirty for new June 7, 2016
Rated 5 out of 5�by Sfarley Great bat! Perfect bat for fast pitch; great distance and no vibration on hits. May 16, 2016
Rated 5 out of 5�by baylee2514 Dinger Bat!! I got this bat for Christmas and love it! Perfect grip and great control. March 29, 2016
Rated 5 out of 5�by Ernienrio Great Pop My daughter has tried a number of different bats from both Easton and Louisville Slugger. The ball comes off the Xeno much better than any other bat. November 4, 2015
Rated 5 out of 5�by Squire1 Grand slam during first game after purchase. Store personnel helpful with selection. Purchased for a 15 yo. playing on a traveling team in TN. She is well pleased with the bat. June 22, 2015
Rated 5 out of 5�by Kim Great Bat I bought this for my daughter...she crushes the ball with it! June 22, 2015
Rated 5 out of 5�by Softballmom00 Excellent bat! Bought this bat for my daughter (plays 18U Gold) after she had borrowed a teammates bat. She loves the balanced feel and the drop 10 gives her control and she can still get plenty of power thru the zone. May 12, 2015
Rated 5 out of 5�by Anon Great Bat great pop when you hit the ball and a smooth swing. would recommend to anyone who asks March 7, 2015
Rated 5 out of 5�by MaddieeMo45 The product is one you want to buy. I love this bat! It has great feautures and is just a comfortable feel when I use it/swing with it. The pop on this bat is great, and it is very durable. If you are looking for a new bat, I would definitely recommend this one--great choice, great company. March 3, 2015
Rated 5 out of 5�by Brooke Nothing else compares struggling to find a great bat to use, I found the older model of this version & absolutely loved it. Ever since I have bought no other bat type or name. I recently purchased this model & it's fantastic. It has great pop. One of the best type of bat yet March 2, 2015


text: In stress corrosion, the tensile stress (typically caused by internal pressure) and the corrosion (typically caused by oxygen in the fluid) work hand in hand to start and grow cracks. In what way does the mechanical stress enhance corrosion? In what way does the corrosion increase mechanical stress? Are their effects roughly equal, or are there conditions where one dominate


text:
Xerostomia After Radiation
Dear OncoLink "Ask the Experts,"
I completed radiation and chemo treatments for head and neck cancer almost 2 years ago. I am now 37 and lead a pretty active and normal lifeexcept, that is, for food! Everything is so dry and difficult. Is there anything I can do?
Katrina Claghorn, MS, RD, registered dietitian at the Abramson Cancer Center of the University of Pennsylvania, responds:
Radiation and chemotherapy can sometimes cause permanent dry mouth or xerostomia. This makes eating very difficult since saliva functions not only to moisten foods, but is also important in conferring flavor. Consequently eating becomes more difficult and foods lack taste. Here are some general nutrition tips:
Probably the best suggestions come from those who have experienced similar problems. Support groups for patients and survivors of head and neck cancers often have meetings that focus on nutrition issues.
OncoLink is designed for educational purposes only and is not engaged in rendering medical advice or professional services. The information provided through OncoLink should not be used for diagnosing or treating a health problem or a disease. It is not a substitute for professional care. If you have or suspect you may have a health problem or have questions or concerns about the medication that you have been prescribed, you should consult your health care provider.
Information Provided By: www.oncolink.org | © 2016 Trustees of The University of Pennsylvania


text:
The Beauty and Brutality of Images That Reach Far Beyond the Headlines
AMSTERDAM—Jodi Bieber's photo of a refugee from Afghanistan's Uruzgan region has already become an icon. The portrait shows a close-up of Bibi Aisha, a young woman whose face was disfigured, allegedly by her husband and family, deep in Taliban territory. The photo, featured on the cover of Time magazine in August, jars the viewer by blending a stylized artistic aesthetic with photojournalism's blunt power to illustrate brutal realities.
It has sparked debate about the moral ambiguities surrounding the idea of a Western military withdrawal from Afghanistan. And it won this year's edition of World Press Photo, the traveling exhibition that opened in Amsterdam's Oude Kerk on April 22 and will hit dozens of cities world-wide.
The exhibition of some of the best photojournalism from 2010 comes as the profession mourns two of its most uncompromising members, war photographers Chris Hondros and Tim Hetherington, who died while covering the conflict in Libya. Mr. Hetherington won the competition in 2007.
One of the exhibition's most laudable attributes has always been its ability to pull visitors into stories that had largely gone unnoticed —an especially helpful quality in a year in which the pace of world events makes last year's headlines seem distant memories. A number of shocking images recall the earthquake that ravaged Haiti in January 2010. Most memorable among them is Riccardo Venturi's black-and-white shot of a dazed child standing in front of a burning colonial church in Port-au-Prince that looks ready to collapse. Javier Manzano's frame of a man's severed head eulogizes the 15,000 victims of Mexico's drug cartels in 2010.
Some of the most intimate and vibrant work is created far away from the headlines. Darcy Padilla's nine-image panel of the troubled life of impoverished mother Julie Baird represents 18 years of work, while Martin Roemers's colorful shots of street life in Mumbai bring to life the theme of humanity's increasing urbanization.
Until June 19
- 1


text:
CNN cited the American Immigration Council's recent report ...
Litigation Clearinghouse Newsletter Vol. 1, No. 3
This issue covers the favorable district court order in the ADIT litigation (Santillan v. Gonzales) and recent decisions addressing Matter of Grijalva and the presumption of effective service.
Published On: Monday, January 9, 2006 | Download File
Read Our Blog
Read the latest in immigration news at ImmigrationImpact.com, with new articles published every weekday.
Text FACTS to 51555 to get the latest posts sent right to your phone.
Immigration by State
Find out how much Latinos, Asians and immigrants contribute to your state.
U.S. Immigration Guide
Read our guide to how the United States immigration system works, and our resource page on the problems with it, as well as the possible solutions.


text:
- About Us
- Nanotechnology
- News
- Columns
- Products
- Directories
- Career Center
- Nano-Social Network
- Nano Consulting
- My Account
Home > News > What it takes to work in nanotech
August 2nd, 2004
What it takes to work in nanotech
If scientific disciplines were dishes on the menu of a Chinese restaurant, nanotechnology would be accompanied by five red stars - the field is hot. It should come as no surprise then, that along with headlines and boatloads of government funding and investment dollars, nanotechnology is also grabbing the attention of jobseekers. But what does it take to work in nanotechnology?
|Related News Press
SUNY Poly Welcomes DPS as the Global Engineering Firm Opens Its U.S. Advanced Technology Group Headquarters at Cutting-Edge ZEN Building November 20th, 2015
SUNY Poly CNSE Announces Milestone as M+W Group Opens U.S. Headquarters at Albany Nanotech Complex and Research Alliance Begins $105M Solar Power Initiative October 20th, 2015
Global Engineering Firm DPS to Establish U.S. Advanced Technology Group Headquarters at SUNY Poly CNSE and Create 56 New Jobs Under STARTUP-NY Initiative October 6th, 2015
SUNY Poly Announces Joint Development Agreement with INFICON to Establish Cutting Edge R&D Partnership Supporting New York State's Rapidly Expanding Nanoelectronics Industry September 23rd, 2015
|The latest news from around the world, FREE
|Premium Products
Only the news you want to read!
Learn More
University Technology Transfer & Patents
Learn More
Full-service, expert consulting
Learn More