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Just a few short months ago the Vancouver Athletics commission did not allow MMA shows to take place in their jurisdiction. The WFF and their promoter, David Lea set off to change that with WFF 3, they showed the commission how safe and professional the sport of MMA really was, and it was time for WFF 4 to show the fans what it was they already knew, that MMA was the best and most exciting show in the world. With the support of the Vancouver Athletics commission in tow for the second show in the history of MMA, the WFF was looking to expand on the success of previous endeavors. The trials and tribulations of the past hurdles were behind them, the public lenience and allowance of having an "Ö.K" show in the face of all these problems were gone. No more excuses, It was time for the WFF to show the fans of the sport in Vancouver what the had to offer the entertainment world. Would they deliver or would they falter in the face of the biggest show in their history?
Denis Kang Vs Chris Peak
The main event fighter of the inaugural WFF show in Kelowna, was back to headline the show for the third time out of four shows. His first time out he faced off against well known Dennis Hallman and gave him all he could handle before throwing an illegal kick that knocked out Hallman and a No Contest ensued. He returned for WFF 2 and took on muscle-bound heavyweight Shane Biever and defeated him via armlock in the first round to take the win in convincing fashion. Two losses in a row, one to Joe Doerkson in the UCC, and the second against Jason Miller in Extreme Challenge had him on the lookout to get back on the winning track. His Opponent was originally scheduled to be Stephane Potvin but a serious Rib injury incurred while training his partner Kristof Midoux forced him to the sidelines. In stepped Chris Peak with 12 hours notice to fill the main event bout against a tough Dennis Kang in a title bout. It was clear from the outset that Kang was focused and ready to snap his losing streak, Kang caught a mid trajectory kick by Peak and took the fight to the mat. Kang who was had competed in the Abu Dhabi qualifiers in San Diego quickly passed the guard and took Peaks back, the obligatory rear naked ensued. The fight was over in 57 seconds and Kang had what he came for. Kang wins via rear naked Choke at :57 seconds of round one. Cameron Brown Vs Bill Mahood
This fight would be a rematch, Mahood bettered Brown via TKO in April of 2002 and Brown was looking for revenge. Mahood had been quite active of late competing regularly butt Brown had not competed in quite some time, his last fight being a loss to Jason Mcdonald in the MFC. In the past WFF, Brown was set to face off against MFC veteran Chris Peak, but Peak was unable to fight due to internal bleeding caused buy a rib bone puncturing his intestines after a visit to Tony Romas, but the layoff did not seem to negatively affect Browns performance on this night. This marathon battle was back and forth for the duration of the three five minute rounds with both fighters refusing to give an inch. Neither fighter wanted another blemish on their records and their hearts showed it in spades, with both fighters in dominant positions at one point or another during the fight and both fighters hurting each other with strikes. Spinning back kicks, haymakers, hammerfists and knees were in full force for the second best fight on the night. The fight was evenly matched up and if it wasnt for the Ulysses Castro Vs Yan Pellerin fight, this fight would have easily been the fight of the night. Knees from the clinch, takedowns galore, and punishment from all facets of an MMA fight littered this fight and both fighters came out with a well deserved draw after three hard fought rounds of action. This fight was declared a majority draw after three five minute rounds.
Max Little Sumo Marin Vs Curtis Brigham
Coming off a loss to fellow card-mate Ivan Menjivar after a three fight winning streak that included wins over Ryan Diaz and Jason Towns, the champion of the 145 division in the WFF was ready to resume his winning ways and on his road to victory stood Curtis Brigham. Rings veteran Curtis Brigham was a relative unknown but had been in the ring with qualified fighters such as CJ Fernandez and future UFC 42 main event headliner Sean "The Shark" Sherk. Max Marin was the heavy favorite coming into this bout but Brigham seemed focused and ready for battle. His focus would pay off as he easily dispatched of the heavily favored Max Marin taking his back and after a couple of failed attempts finally sinking the tight rear naked choke at 56 seconds of the first round. Brigham takes the WFF 145 title in impressive fashion. Brigham Wins via rear naked choke at 56 seconds of round 1
Ivan Menjivar Vs Brandon Shuey
Relatively unknown outside of Canada but considered to be one of the premier 145 fighters in the sport, Menjivar has even moved up two weight classes and fought one of the premier 170 pounders in the world in Jason Black in past events. Even in the loss he was impressive in his resolve and went on to defeat competitors such as former WFF champion Max Marin and tough Jiu Jitsu man Jeff Curren. Ivan Menjivar as always looked calm and collected in the ring, he methodically worked the fight to the mat, softened Shuey up with solid blows from the guard, and eventually swung around from the top position and took the very slick looking kneebar at 38 second mark of the first round. Menjivar once again served notice that he skills are for real. Menjivar wins via Kneebar round 1, 0:38 seconds
Ulysses Castro Vs Yan Pellerin
Yan Pellerin took the fight on two days notice and ate over a 50 pound weight difference to come and compete in the show. He showed the heart and determination of a champion in the face of an uphill battle and put on the fight of the night, and an early candidate for the fight of the year with the help of Ulysses Castro. Castro is coming off recent wins over Kevin Psaila, Paul Trudel, Shane Biever and most recently the world famous Dan "The Beast" Severn so his talents are for real. Originally scheduled to face off against Kristof Midoux, a hand injury forced Midoux to the sidelines and propelled Pellerin into the fight on short notice. Pellerin started the contest out very quickly landing straight shots to the nose and face of Castro, it looked like Castro would be in a bit of trouble early on and his battered and bloodied nose told the story of the punishment he was taking. He battled however and the ref came in and halted the action to take a closer look at the nose. The nose looked to be in bad shape but not enough to stop the fight and he took advantage of the opportunity fighting back and stunning Pellerin on several occasions to return the favor. At the midpoint of the first round Castro was able to get the mount on Pellerin, Pellerin however, was able to jab off his back and rebloody the nose of Castro and his nose started bleeding into the mouth of Pellerin. Pellerin gagged and the ref stopped the fight in favor of Pellerin due to the profusely bloody nose of Castro, even though Castro was in the mount position. Confusion ensued and the bout was restarted after a five minute rest period for both fighters. When the fight continued both fighters batlled hard again exchanging blow after blow to the face in the standing position until Yan was taken to the ground by Ulysses Castro and Castro took the back mount and choked him out rear naked style. The ending to the fight was controversial and after a talk to the referee the promoter of the event and several others on the scene we were told that the fight may be declared a no contest but that is uncertain at this point. One thing that was for certain was the whole building exploded while this fight was taking place and the crowd came alive during this bout.
Nick Ring Vs Kevin Dolan
One of the more lopsided bouts of the evening saw Kevin Dolan absorbing more then his fair share of punishment for the duration of the short bout. Dolan was staggered early, taking a head kick to start the bout, and things did not improve from there. Knees and eventually punches came at him in waves until he had absorbed enough punishment to the head and tapped out at 1:20 of the first round. Dolan never really mounted any offence before Ring pounced on him and secured the outcome of the bout early. Nick Ring wins via Tapout at 1:20 in round one.
In Preliminary Action"Click on the Images to enlarge"
Paul Forde defeated Mike Bosa via armlock in a good display of heart and determination. Forde was losing the fight on the strength of a vicious ground and pound attack of Mike Bosa who looked very calm and collected in the ring. Forde bided his time until he was able to secure the tight armbar forcing Bosa to tap and into the losers column. Forde takes the victory at 4:20 of the first round.
Chad Hamzeh defeated Justin Livingston via Judges decision. Livingston was able to ground and pound his way to a strong round one but the tides turned in the second round. Hamzeh was able to take the top position and rain solid blows to the face and body of Livingston and did enough damage in the second round to get the judges decision in his favor after two hard fought rounds.
Len Smith was able to defeat Rob Acton in the first preliminary bout of the evening by rear naked choke at 3:48 of the first round.
A Look Back
I didnt know what to expect on the heels of an average show the last time out for the WFF. The WFF 3 event was marred with bad luck as injuries, no shows and even accidents such as Chris Peak puncturing his intestines from swallowing a rib bone the night before his fight stained a once promising card. The bad luck was still in the air as Kristof Midoux, Stephane Potvin and others had to drop out of their fights on short notice but the pleasant surprises were many on this night as well. Almost all of the fights went off without a hitch and in terms of excitement, the fights themselves turned out to be among the best in the history of the WFF, A great way to kick off the WFFs second show in Western Canada under the watchful eye of the Vancouver Athletics commission. The Crowd looked to be pumped and very excited about the card that took place and the first fireworks show for the WFF were a nice touch. To top things off international MMA superstar Carlos Newton was in attendance looking on and made an appearance to the delight of the fans. All the right things went right this time and the bad luck was not the factor it was the last time the show rolled into town. The strengths of the show in all other facets of the game vastly outweighed any negatives on this night. All the factors added up to a very entertaining package that was well worth the price of admission, with the show rolling and the experience of another show in their books, it is looking like the WFF has nowhere to go but upwards and onwards, bad luck be damned.


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Accellion offers the industry's widest set of enterprise deployment options including public, private and hybrid cloud deployment and FIPS 140-2 certified environments. All Accellion deployment options can be mixed and matched. View Accellion Cloud Deployments Datasheet >>
Private cloud deployment ensures the availability, integrity and confidentiality of information. Accellion offers private cloud/on-premise solutions with support for VMware, Citrix XenServer, and Microsoft Hyper-V virtual environments. Deployment of an Accellion private cloud is as simple as a software download, enabling rapid enterprise-wide deployment.
Public cloud deployment of Accellion on Amazon EC2 enables rapid implementation of mobile file sharing to fix network security deficiencies, alleviate overloaded email systems, or to manage spikes in usage. Instead of installing hardware, or downloading and configuring software, the Accellion public cloud deployment provides immediate deployment to internal and external users. The result is reduced time to address security vulnerabilities and share information securely to enhance business productivity.
For enterprises requiring flexible deployment options across the globe, including on-premise private cloud to store sensitive data in specific regions, and public cloud deployments to rapidly scale their own IT infrastructure, Accellion hybrid cloud solutions combine the control of the private cloud with the flexibility of the public cloud.
For government agencies requiring FIPS 140-2 compliance, Accellion offers a FIPS 140-2 Certified module for its secure mobile file sharing solutions for public, private and hybrid cloud deployments. Accellion has completed the rigorous validation process and obtained certification by the Cryptographic Module Validation Program (CMVP) to meet the security requirements set forth for Federal organizations by the National Institute of Standards and Technology (NIST).

subset: commoncrawl


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Rolex Rankings #13
Rolex Rankings #14
This is the first year for the event.
Will Inbee Park defend her title?
Read all about the first tournament of the season.
Fun Fact Friday is a new weekly series where LPGA.com will share with you five fun facts about a player.
Kia Performance Awards Update: Tseng most compelling performance for her back to back wins.


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What health care plan is offered by the University Hospital? Very few fellowships can match University of Iowa's health care plan for fellows. Health care, including medication, for the fellow, his/her spouse and children are free. If you and your spouse decide to have a child you will pay nothing. Prenatal care, ultrasound, the delivery, etc. is free. Fellows can also obtain several over the counter medications for free from the Pharmacy. In addition, at no cost, you are provided a Blue Cross/Blue Shield coverage plan in case you or your family is injured or becomes ill outside of Iowa City. The plan includes dental coverage at no additional cost.
What Pathology fellowships are available at Iowa? There are fellowships available in surgical pathology, cytopathology, hematopathology, microbiology, blood/bank transfusion medicine, and molecular pathology.
How is vacation time handled? Fellows have 15 weekday vacation days a year. Professional leave for meetings is negotiated on an individual basis. Leave is granted for National Board exams and American Board of Pathology exams but not for board preparation courses. For job interviews or board preparation courses, each house staff member will be allowed five working days of leave. Additional days taken for job interviews or board preparation courses must use vacation.
What about fringe benefits such as book/travel funds? Each fellow is given $1500/year for books/journals, meetings or memberships. Travel to national conferences is paid for by the department for fellows presenting abstracts.
How well do Iowa fellows fare in finding jobs after training? The established reputation of excellence in training at the University of Iowa, combined with the recent trend of increasing demand and aging of current pathologists, has meant a tremendous opportunity for fellows from our program. All departing fellows in recent years have had no difficulty getting offers for desirable positions in both academic and private settings.
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Linda Elliott Cytopathology Fellowship Coordinator
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Copyright © 2014 The University of Iowa. All Rights Reserved.


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Burden Of Proof is the new studio release from Soft Machine Legacy.
Recorded in Italy during the closing months of 2012, the album features former Soft Machine members John Etheridge, Roy Babbington and John Marshall alongside Theo Travis (who contributes Tenor Sax, Flute and Fender Rhodes)
Taking the style of Soft Machine into the 21st Century, Burden Of Proof is another outstanding SML album, containing new compositions and a new recording of Hugh Hopper's Kings And Queens (originally from Fourth).
The first 2000 copies are available in a special digi-pack.


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North Georgia Buries Carson-Newman 104-95
DAHLONEGA, GA – North Georgia used
balance scoring and timely shooting to take down Carson-Newman
104-95 Wednesday night in non-conference action. The Saints placed
five players in double-figures to come away with the nine-point
North Georgia improves to 6-1 on the season, while Carson-Newman will enter the 2009 calendar year with a record of 4-8.
The Saints jumped out to an early lead with a barage of three-pointers to take an 18-10 advantage with 16:12 remaining in the half. North Georgia led by as many as 10 points in the first period, but Carson-Newman's Joey Cameron knocked down a pair of buckets late to cut the lead to six at 56-50 heading into halftime.
North Georgia continued to push the tempo in the second half and led by as many as 17 points with 12:02 remaining on a layup by Brody Langston. Adam Plavich brought the Eagles right back into the game with four long balls in the second period, cutting the Saints lead to just a bucket at 96-94 with 3:25 remaining in the contest.
The Saints rallied over the last three minutes, holding Carson-Newman without a field goal while going on an 8-1 run to come away with the 104-95 victory.
Senior Anthony Rowe carried the offense with 20 points on 8-11 shooting, while pulling down 12 rebounds for his third straight double-double. Andre Morgan poured in 14 first-half points and finished with 20 points and five steals. Three other players scored in double figures, including Michael Moynihan and LaBrian Lyons who tallied 17 apiece, while Langston chipped in 12 points and five rebounds.
Camerson led all scorers with 24 points and 10 rebounds for a double-double, while Plavich drained six three-pointers for 18 points in 23 minutes of action. Camerson Sharp added 13 points on 5-8 shooting.
The Saints shot 49 percent for the contest, while Carson-Newman was 45 percent from the field and outrebounded North Georgia 46-45.
North Georgia returns to action on the road, taking on 2nd-ranked USC Aiken as PBC play resumes on Saturday, January 3, 2009. Tip-off is scheduled for 7:30 p.m. in the Pacer's Convocation Center.


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The Daily Word in Marquez' death, a Russian firefighter and a balloon crash
Writer Gabriel Garcia Marquez died yesterday at the age of 87.
Yesterday, Missouri police arrested a suspect, accused of a string of vehicle shootings on Kansas City highways.
Relatives of those who were on Flight MH370, which disappeared weeks ago, want answers.
An avalanche swept down Mt. Everest, killing at least 13 people.
The City settled several lawsuits from people who were arrested or cited for feeding the homeless.
Earlier this morning, a hot air balloon crashed into a house in the Sage and Unser area.
Gov. Susana Martinez addressed negative things that were said on secret audio recordings from four years ago, pero she won't say "sorry" because they were private.
A medical marijuana supplier wants to give people a mall-like experience. In that case, do they provide free samples?
Get Your Beep-Boop On: Play Yars' Revenge at the Tannex
Do you get misty for those halcyon days of 1982, when you were a giant space wasp hell-bent on picking your way through the enemy's defenses and destroying their cannon before it destroyed you? Even if you weren't born yet, the game Yars' Revenge kindles this need within you.
Luckily, tomorrow night, the Tannex is hosting a Yars' Revenge event. Swing by 1417 Fourth Street SW after 8pm. For $5 you get to manhandle the joysticks of two Atari Flashback systems in any of 64 classic games, including Asteroids, Centipede, Pitfall!, Breakout and possibly the single most embarrassing video game of all time, Video Checkers. (Kidding, of course; E.T. the Extra-Terrestrial has that "honor.")
Live electronica completes the evening, courtesy of local acts Huron Valley Listening Club, Lenn Cicada and Meta Vaux. While waiting your turn to settle that 30-year Galaga grudge match with your sister, you can fight over who has to be P2 next time, or plan a field trip to the Atari landfill excavation we hear is launching in Alamogordo on April 26. Tannex • Sat Apr 19 • 8pm • $5 • ALL-AGES! • View on Alibi calendar
University of Connecticut Women's Team Destroys Notre Dame in NCAA Final
But does basketball matter if few people watch?
A week ago, the NCAA Division I basketball tournament reached its apex. And the University of Connecticut won. Nope, not the men's game, which was fantastic, sure, but the women's game. It was truly historic, and not just according to the wonks at 538, the newly minted sports blog from famed statistician Nate Silver. While there have been undefeated teams ostensibly playing for a national championship before—in college football at least—that's never been the case in basketball.
Many say the latest victory for the UConn women represents an endorsement of their coach, Geno Auriemma. With long-time rival Pat Summitt retired, it seems as though almost no one can stand in the way of the Huskies and their long-running records. Notre Dame fought valiantly for their place as the spoiler, and maybe if they'd had Natalie Achonwa or Ace playing alongside her senior teammates, things could have gone differently.
There's no shame in losing to this UConn team, but there are definitely columnists who have wondered if all those Husky wins piling up are leading to Geno and Co. fatigue. While Mechelle Voepel argues that UConn's winning ways are good for women's basketball overall, there's definitely room for disagreement. Kate Fagan reasons that games are better when they're truly competitive and if Notre Dame represents the best team that UConn had to face, things are getting into a bad place. The bottom line: We need a multitude of better teams, not just UConn.
The takeaway a week later, with almost no one talking about the women's game, despite the WNBA Draft already occurring, is that NCAA Division I basketball is still all about the men's game. March Madness, to most people, means men's games exclusively. Even if—or rather, when—two undefeated teams play, something that has never happened in the sport before, there's very little attention for the women. Something needs to change.
This Week at Guild Cinema
We screwed up! We didn't get Guild Cinema's regular ad in this week's print edition of Weekly Alibi. Here, now, is the ad that should have run, in all its glory. We're sorry, movie fans!
The Daily Word in V.23 No.16, H&M and Neutral Milk Hotel
The latest issue of your favorite alt.weekly—that's us, the Alibi—is chock-full of rad content. To wit, test your New Mexico news savvy with our weekly pop quiz, Crib Notes.
Read, critique and even comment on—as Facebook commenting is now live on alibi.com—an editorial, "Department Corrections," about the DOJ's findings in its investigation into APD, many unanswered questions and the future of our city.
Check out Alibi Film Editor Devin D. O'Leary's review of Jonathan Glazer's Under the Skin, you know, that experimental sci-fi flick starring Scarlett Johansson as a predatory alien siren.
Four Up delivers deets on Zimbabwean electric protest songs by Thomas Mapfumo & the Blacks Unlimited—this one's tonight!—and poptastic electro, pop-punk, alt.folk, and bilingual feminist hip-hop concerts. (Live music is one of the finest anodynes available.)
Genevieve Mueller reports on Albuquerque's growing, thriving improv scene in "Yes and ... Where Do We Go From Here?"
Gail Guengerich gets her French-American fusion on in "Ouvrez La Bouche."
In search of new tuneage? Read our micro reviews of new releases from NEEDTOBREATHE, The Tower and Todd Terje in Sonic Reducer.
From Nuevo Mexicano artist/architect William Lumpkins serigraphs and felt-tip pen drawings to bibliophile pr0n, an urban renewal keynote and hangs with famous authors in a Fe movie theater, stay art-smart with Culture Shock.
Are you getting your RDI of Pulitzer Prize-winning feature writing?
Hip Swedish fashion empire H&M is coming soon to Burque.
Catch the Neutral Milk Hotel reunion tour tonight in Burque.
The readers voted, we tallied the results, now find out who and what was voted Best of Burque 2011.
Iced Earth • 5.15.2014
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A Clinical Study for Patients With Neurogenic Orthostatic Hypotension (NOH) Using Droxidopa (NOH301)
- Full Text View
- Tabular View
- Study Results
- Disclaimer
- How to Read a Study Record
The purpose of this study is to see whether droxidopa is effective in treating symptoms of neurogenic orthostatic hypotension in patients with Primary Autonomic Failure (Pure Autonomic Failure, Multiple System Atrophy, Parkinson's Disease), Non-diabetic neuropathy, or Beta Hydroxylase deficiency.
Symptomatic Neurogenic Orthostatic Hypotension (NOH)
Non-diabetic Neuropathy
Primary Autonomic Failure
Dopamine Beta Hydroxylase Deficiency
Drug: Placebo
Drug: Droxidopa
Phase 3
|Study Type:
|Study Design:
|Allocation: Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Parallel Assignment
Masking: Double Blind (Subject, Caregiver, Investigator)
Primary Purpose: Treatment
|Official Title:
|Phase III, Multi-Center, Study to Assess the Clinical Effect of Droxidopa in Subjects With Primary Autonomic Failure, Dopamine Beta Hydroxylase Deficiency or Non-Diabetic Neuropathy and Symptomatic NOH
- To evaluate the efficacy of droxidopa in patients with symptomatic NOH as measured by the relative change in mean score of the composite Orthostatic Hypotension Questionnaire(OHQ) 7 days following randomization to treatment with droxidopa or placebo. [ Time Frame: 7 days ] [ Designated as safety issue: No ]
- Evaluate efficacy of droxidopa as measured by changes in systolic blood pressure (SBP) and diastolic blood pressure (DBP) measurements 3 minutes post standing; [ Time Frame: 7 days ] [ Designated as safety issue: No ]
|Study Start Date:
|September 2008
|Study Completion Date:
|September 2010
|Primary Completion Date:
|September 2010 (Final data collection date for primary outcome measure)
|Assigned Interventions
Active Comparator: Droxidopa
100 mg, oral, three times per day 200 mg, oral, three times per day 300 mg, oral, three times per day 400 mg, oral, three times per day 500 mg, oral, three times per day 600 mg, oral, three times per day
Drug: Droxidopa
100 mg, oral, three times per day 200 mg, oral, three times per day 300 mg, oral, three times per day 400 mg, oral, three times per day 500 mg, oral, three times per day 600 mg, oral, three times per day
Other Name: Droxidopa
Placebo Comparator: Placebo
100 mg, oral, three times per day 200 mg, oral, three times per day 300 mg, oral, three times per day 400 mg, oral, three times per day 500 mg, oral, three times per day 600 mg, oral, three times per day
Drug: Placebo
100 mg, oral, three times per day 200 mg, oral, three times per day 300 mg, oral, three times per day 400 mg, oral, three times per day 500 mg, oral, three times per day 600 mg, oral, three times per day
Other Name: Placebo
Detailed Description:
Systolic blood pressure is transiently and minimally decreased in healthy individuals upon standing. Normal physiologic feedback mechanisms work through neurally-mediated pathways to maintain the standing blood pressure, and thus maintain adequate cerebral perfusion. The compensatory mechanisms that regulate blood pressure upon standing are dysfunctional in subjects with orthostatic hypotension (OH), a condition that may lead to inadequate cerebral perfusion with accompanying symptoms of syncope, dizziness or lightheadedness, unsteadiness and blurred or impaired vision, among other symptoms.
The autonomic nervous system has a central role in the regulation of blood pressure. Primary Autonomic Failure is manifested in a variety of syndromes. Orthostatic hypotension is a usual presenting symptom. Primary Autonomic Failure may be the primary diagnosis, and classifications include pure autonomic failure (PAF), also called idiopathic orthostatic hypotension (Bradbury-Eggleston syndrome) autonomic failure with multiple system atrophy (Shy-Drager syndrome) and also Parkinson's disease. Regardless of the primary condition, autonomic dysfunction underlies orthostatic hypotension.
Orthostatic hypotension may be a severely disabling condition which can seriously interfere with the quality of life of afflicted subjects. Currently available therapeutic options provide some symptomatic relief in a subset of subjects, but are relatively ineffective and are often accompanied by severe side effects that limit their usefulness. Support garments (tight-fitting leotard) may prove useful in some subjects, but is difficult to don without family or nursing assistance, especially for older subjects. Midodrine, fludrocortisone, methylphenidate, ephedrine, indomethacin and dihydroergotamine are among some of the pharmacological interventions that have been used to treat orthostatic hypotension, although only midodrine is specifically approved for this indication. The limitations of these currently available therapeutic options, and the incapacitating nature and often progressive downhill course of disease, point to the need for an improved therapeutic alternative.
The current withdrawal design study will measure the efficacy of droxidopa on symptoms of neurogenic orthostatic hypotension in patients randomized to continued droxidopa treatment versus placebo, following 14 days of double-blind treatment.
droxidopa [also, known as L-threo-3,4-dihydroxyphenylserine, L-threo-DOPS, or L-DOPS] is the International non-proprietary name (INN) for a synthetic amino acid precursor of norepinephrine (NE), which was originally developed by Sumitomo Pharmaceuticals Co., Limited, Japan. It has been approved for use in Japan since 1989. Droxidopa has been shown to improve symptoms of orthostatic hypotension that result from a variety of conditions including Shy Drager syndrome (Multiple System Atrophy), Pure Autonomic Failure, and Parkinson's disease. There are four stereoisomers of DOPS; however, only the L-threo-enantiomer (droxidopa) is biologically active.
The exact mechanism of action of droxidopa in the treatment of symptomatic NOH has not been precisely defined; however, its NE replenishing properties with concomitant recovery of decreased noradrenergic activity are considered to be of major importance.
Droxidopa has been marketed in Japan since 1989. Data from clinical studies and post-marketing surveillance programs conducted in Japan show that the most commonly reported adverse drug reactions with droxidopa are increased blood pressure, nausea, and headache. In clinical studies, the prevalence and severity of droxidopa adverse effects appear to be similar to those reported by the placebo control arm.
|Ages Eligible for Study:
|18 Years and older
|Genders Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
To be eligible for inclusion, each patient must fulfill the following criteria:
- Male or female and aged 18 years or over
- Clinical diagnosis of orthostatic hypotension associated with Primary Autonomic Failure (PD, MSA and PAF), Dopamine Beta Hydroxylase Deficiency or Non-Diabetic Autonomic Neuropathies
- A documented fall in systolic blood pressure of at least 20 mmHg, or in diastolic blood pressure of at least 10 mmHg, within 3 minutes after standing;
- Provide written informed consent to participate in the study and understand that they may withdraw their consent at any time without prejudice to their future medical care.
Exclusion Criteria:
- Currently taking ephedrine or midodrine
- Patients taking ephedrine or midodrine must stop taking these drugs at least 2 days prior to their baseline visit (Visit 2).
- The use of short-acting anti-hypertensive medications at bedtime is permitted.
- Currently taking tri-cyclic antidepressant medication or other norepinephrine re-uptake inhibitors;
- Have changed dose, frequency and or type of prescribed medication, within two weeks of study start (excluding ephedrine and midodrine)
- History of more than moderate alcohol consumption
- History of known or suspected drug or substance abuse
- Women of childbearing potential who are not using a medically accepted contraception
- For WOCP a serum beta HCG pregnancy test must be conducted at screening, and a urine pregnancy test must be conducted at baseline and study termination; the results must be negative at screening and at baseline for the patient to receive study medication.
- Sexually active males whose partner is a WOCP and who do not agree to use condoms for the duration of the study and for 30 days after the last dose;
- Women who are pregnant or breast feeding
- Known or suspected hypersensitivity to the study medication or any of its ingredients
- Pre-existing sustained severe hypertension (BP 180/110 mmHg in the sitting position)
- Have atrial fibrillation or, in the investigator's opinion, have any other significant cardiac arrhythmia
- Any other significant systemic, hepatic, cardiac or renal illness
- Diabetes mellitus or insipidus
- Have a history of closed angle glaucoma
- Have a known or suspected malignancy
- Have a serum creatinine level > 130 mmol/L
- Patients with known gastrointestinal illness or other gastrointestinal disorder that may, in the investigator's opinion, affect the absorption of study drug
- In the investigator's opinion, have clinically significant abnormalities on clinical examination or laboratory testing
- In the investigator's opinion, are unable to adequately co-operate because of individual or family situation
- In the investigator's opinion, are suffering from a mental disorder that interferes with the diagnosis and/or with the conduct of the study, e.g. schizophrenia, major depression, dementia
- Are not able or willing to comply with the study requirements for the duration of the study
- Have participated in another clinical trial with an investigational agent (including named patient or compassionate use protocol) within 4 weeks before the start of the study
- Previous enrolment in the study.
Show 21 Study Locations
|Principal Investigator:
|Stephen Greer, MD
|Arkansas Cardiology
|Principal Investigator:
|Alberto Vasquez, MD
|Suncoast Neuroscience
|Principal Investigator:
|Richard Hull, MD
|North Alabama Neuroscience
|Principal Investigator:
|Brent Goodman, MD
|Mayo Clinic
|Principal Investigator:
|Alvin McElveen, MD
|Bradenton Neurology, Inc
|Principal Investigator:
|Mazen Dimachkie, MD
|University of Kansas
Additional Information:
No publications provided
|Responsible Party:
|Chelsea Therapeutics
|ClinicalTrials.gov Identifier:
|NCT00782340 History of Changes
|Obsolete Identifiers:
|Other Study ID Numbers:
|Droxidopa NOH301
|Study First Received:
|October 29, 2008
|Last Updated:
|March 21, 2013
|Health Authority:
|United States: Food and Drug Administration
Keywords provided by Chelsea Therapeutics:
Neurogenic Orthostatic Hypotension
Orthostatic hypotension
Pure Autonomic Failure
Multiple System Atrophy
Autonomic Failure
Dopamine Deficiency
Additional relevant MeSH terms:
Hypotension, Orthostatic
Autonomic Nervous System Diseases
Pure Autonomic Failure
Vascular Diseases
Cardiovascular Diseases
Orthostatic Intolerance
Primary Dysautonomias
Nervous System Diseases
Antiparkinson Agents
Anti-Dyskinesia Agents
Central Nervous System Agents
Therapeutic Uses
Pharmacologic Actions
Cardiotonic Agents
Cardiovascular Agents
Autonomic Agents
Peripheral Nervous System Agents
Physiological Effects of Drugs
Dopamine Agents
Neurotransmitter Agents
Molecular Mechanisms of Pharmacological Action
Protective Agents
ClinicalTrials.gov processed this record on April 23, 2014


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Pumpkin Seed Necklace
This Pumpkin Seed Necklace is an old favorite updated in Halloween colors.
SuppliesPumpkin seeds (roasted)
Paint (orange, black, white and green)
Needle and thread
(Kitchen foil to put seeds on while you paint them)
Paint your pumpkin seeds in orange, green, white and black. The easiest way to do this is to put them on kitchen foil so that they will not stick to anything while they dry. But it is a very messy job!
When your seeds are dry, thread your needle with a length of thread long enough to go over your head with 3 or 4 inches to spare. Put your seeds a few at a time on a pile on newspaper or a thin sponge. One by one push the needle down through the seed - when you have pierced the seed safely, pick it up and pull it through the thread.
When your thread is about two thirds filled, knot the ends together tightly.
Note: you need a sharp needle for this so make sure children are well supervised or that an adult does the threading.
Editor's Note: Try this suggestion from Bethe Almeras the Grass Stain Guru "If you don't paint the Pumkin Seeds but roasted them with different flavors you have a healthy version of a Candy Necklace".
Annother Editor's Note: Katje Lehman of katjeblogspot.com suggests that "Instead of painting them, put them in a ziplock bag with drops of food coloring, just like you do macaroni"
This craft reprinted courtesy of ActivityVillage.co.uk.
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Dress Up Crafts, Food Crafts, Halloween Food Crafts
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What do you think?
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Pneumonia, eosinophilic
Other Names for this Disease
- Loeffler syndrome
- Pulmonary infiltrates with eosinophilia
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.
These Web pages are updated as the Genetic and Rare Diseases Information Center receives questions and as new information becomes available. If you don't see many information resources on this page, it may be because the Information Center hasn't yet received a question about this condition.
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Please contact us with your questions about Pneumonia, eosinophilic. We will answer your question and update these pages with new resources and information.
On this page
Basic Information
- MedlinePlus was designed by the National Library of Medicine to help you research your health questions, and it provides more information about this topic.
- The Merck Manuals Online Medical Library provides information on this condition. Click on the link to view the information.
- The National Organization for Rare Disorders (NORD) is a federation of more than 130 nonprofit voluntary health organizations serving people with rare disorders. Click on the link to view information on this topic.
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- Medscape Reference provides information on this topic. Click on the link to view this information. You may need to register to view the medical textbook, but registration is free.
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Your method seems good to me! For good defense ammo on the cheap you can order a box of 50 gold dots for around $20 online.
We all know you are not supposed to carry ammo for self-defense unless it is proven reliable in your gun. Rich guys like you can afford to do that. Poor guys like me can't.
People throw numbers around: "Don't carry any ammo/gun combo unless you have fired N rounds through that gun without a malfunction." Sometimes, N = 200. Sometimes 100. Sometimes 50. Let's consider N = 100.
I was thinking about chandging my carry load to DPX in my .45's. DPX costs roughly $1 per shot. If I want to fire 100 rounds for testing, that's $100. I have 9 .45's that I carry regularly, depending on climate/clothing/whim. One is my bedroom gun, for example. Two are "car guns" -- I leave them in the cars all the time. I have lightweights, full size, stainless, blue, a couple of hi-caps. If I test all of them, that's $900. At some point, it's not a question of "How much is your life worth?" but "How much can you afford to spend testing ammunition?" $100? $1000? $2000? Personally, I think my life is worth a billion dollars, but I can't afford to spend that amount testing ammo. (And then there are the guns in other calibers that I carry sometimes. How much should I budget for them?)
What do you do if you get to Round 90, and you get a malfuction? Forget about that ammunition for that gun? Start over again with another 100, and see if it happens again or if it was a fluke, or a bad magazine? Start over with 100 rounds of a different load, also at a buck a pop?
Also, what do you do if your ammo supply is limited? All my guns except one are "checked out" with Black Talons. I just bought a new gun. Can I trust it with Black Talons? I am down to my last 40 rounds of those. How do I test 100 rounds if I only have 40? Or how about Glasers, at $3.50 a pop, sold in 6-packs?
As you can see, function-testing ammo can run into real money.
Here's my cheap guy method. Maybe you will find it helpful.
Load ball, expensive, ball, expensive, ball, expensive, ball, expensive . Fire one round of ball, and see if the expensive round fed OK. If it did, eject it manually so you have another cheap round in the chamber. Fire ball, check to see if the expensive round fed. Cycle manually. Repeat as much as you want. You can re-use the same expensive rounds over and over again for feed-testing. Just check the re-used rounds for length against an unfired one every once in awhile, to be sure you're not getting bullet set-back, which could cause over-pressure and kB. Last mag before you leave the range will be the expensive rounds you used for feed-testing. That way, you test to be sure the ammo has the right amount of power to cycle your slide.
If the expensive stuff does NOT feed reliably, use it in another gun, use it for chamber-only, sell it or give it away, or use it in a throw-down, so the bad guy will have a gun that doesnt work. (Just kidding, OK?)
It only takes a handful of expensive rounds (and 100 rounds of the cheap stuff) to get 100 feeding tests.
DPX is my carry load now, in 7 of my 9 .45's. (The other 2 I just haven't gotten around to testing with DPX yet.) I've used about $40 worth of ammo, instead of $700.
Anybody else doing this, or am I the only cheapskate around here?
Your method seems good to me! For good defense ammo on the cheap you can order a box of 50 gold dots for around $20 online.
Frist of all why does the ammo have to be special. The 1911/.45 has been through 2 world wars and a couple of conflicks. The 230gr ball ammo has done just fine for our A/Forces. I reload it for about $5.50 for 50@ .11 cents a shot. Wal Mart is $21.00 @ 100 here. that's .21 cents a shot. I can buy another gun on what you are spending on ammo.
Baldy, For self defense, I wouldn't use FMJ in a 45. Just me, personally (the Military SHOULD be using JHP in those Berettas). For target purposes - its great...
But, I think any of the name brand JHP in 45 ACP is fine. Not sure what U are trying to do that costs $1 a round. EVen my PS90 ammo is only maybe 40 cents a round or so. Glazer and all of those other freaky rounds aren't worth it, IMHO...
If you can buy DPX, H-S, GD, Ranger etc. for 40 cents a round, good for you! I pay about 20 cents a pop for WWB and AE hardball, but even if I could find the ammo I want to carry (which happens to be DPX) for 40 cents, 900 rounds for testing (100 rounds for each of my 9 .45's) would be $360. I know to some of you, that's chicken feed.
I just scored 200 rounds of 5.56 TAP (note, not .223) for $190 (i.e., almost a buck a round). I asked a friend of mine if he wanted to buy half. He said no; he wanted to buy a thousand "for practice," because he wants to practice with what he carries. Some people don't need to worry about ammo prices; this thread is not for them.
So, where do I get all this 40-cent DPX ammo?
You could always carry a revolver. Then all you need to worry about is the accuracy of a given load and POI. It's what I do.
I would think that a couple of boxes(100 rounds) would suffice for function testing.
I also think you're placing too much stock in the more expensive, "flashier" bullets. If you can't afford to shoot it, maybe you should go with something you can afford. These bullets aren't going to turn the whole round into a magnum. The bullet isn't going to fly faster nor hit harder just because of the bullet. They might just expand a little more than some of the less expensive ones given the right conditions. If you really think the caliber your carry piece is chambered in is inadequate, a slightly differently formed bullet isn't going to make all the difference. It just gives it a little more expansion under given conditions. But if you can afford the bullet type that you see as ideal, go for it. Otherwise get what you can afford.
When did overpriced bullets make all the difference in power? If a round has inadequate power because of limitations of the cartridge, a bullet that expands a little more just makes it an inadequtely-powered round that expands more. Maybe I should stop ranting and start listening to marketing hype.
Last edited by Revolver; 12-31-2006 at 10:20 PM.
Or, I could do function testing the cheap way, as described above. Nah, I'll just retire the semi-autos. Thanks for the useful advice; I'll get right on it.
When I get a new gun, I fire 200-300 rounds of target ammo. If I have ZERO failures, I fire maybe 15-20 rounds of hollow points. If they function fine, then I am satisfied. I may shoot a few more hollow points on subsequent trips. But, I don't fire 100+ hollow points before I rely on a gun. That is admittedly too expensive.
Last edited by Revolver; 12-31-2006 at 10:50 PM.
With nine .45's, and DPX at $1 a round, I can get 900 test cycles for, say, $300 instead of $900. Even assuming somebody knows a source of 40 cent DPX/HS/GD, etc., and only has one gun to test, the choice is between $40 and $25. If there are people out there who don't need to save money, that's their business, I guess. Whatever....
I know that this stuff is dangerous...but the reloading books I have seen are THICK. I cannot immagine needing all that info to put a few grains of powder into a primed casing, placing a bullet on top, and crimping.
I figure a nice pamphlet should suffice.
Do those books go into great detail as to mixing the powders for certain effects? Can you usually stick with a single powder for most loads? Do you need to learn a lot about metal and metalurgy?
I just don't get it...
I couldn't let that go without a comment.
NEVER, EVER mix powders.
That kind of thinking is exactly why you need to read more than just a
pamphlet before jumping into reloading.
Find a friend who is into reloading and ask him about the subject.
Problem solved. If mixing is not allowed, then reloading is simplified even further. There is only 1 powder to buy...you need to know the weight of the powder, and then assemble the round. I still think a pamphlet could be used to educate the average person.
I am trying to understand how reloading requires such a large book. I mean, I guess every powder is addressed, as is every casing, primer, bullet, press, tumbler...and so on. Is that what is contained in the books? In addition, why should several books be consulted?
If I want to reload ONLY 9mm FMJ for practice...why would I need to read 3 books on the subject? Once I understand how to remove the old primer, and install a new one, and I weigh the powder to the .1 grain (how precise do you need to be?) and I have the equipment, and crimp the bullet...what else is there.
Aside from safety guidelines and procedures...if you are only reloading 1 bullet type for one specific purpose...how could 2000 pages of text be justified?
I must admit that I may also load +P as well, and I would need an extra page or two of explanation as to the safe methods of doing so.
Thank you Milque I'm tired of people saying how much is your life worth.
The average person out there can barely afford health care unless they got insurance and this is a fact most Americans have to live with. So, "how much is your life worth" is getting tiring.
Seeing as you pay as much for 20 specialty rounds as you do for the average 100pack practice ammo. I agree.
When I use to carry Federal Hydra-shocks shooting the stuff was an exuberant luxury. Shooting my gun in general is a luxury. Twenty to forty for ammo plus range fees plus gas plus what ever, it adds up.
Hey Milquetoast...
Your idea is sound for testing feeding issues...but not perfect. It also does not test ejectability of the defensive ammo.
I like the idea of combining your method with a few magazines of pure defensive.
You can cycle 200 rounds of defensive using your method, and only firing 100 practice rounds...but at the end of all that...I recommend shooting 50 rounds in a row of the defensive to ensure that they load after one another. By shooting the rounds consecutively, you ensure that they will cycle with each other. The defensive ammo may have different characteristics than the practice ammo, and thus, the slide will be affected differently.
If my defensive round is a 124gr +P, but my practice round is a 115gr...then the cycle action will be different for both rounds.
If possible, make the practice round as identical to the defensive round as possible...then when you are done with your tests...shoot a few magazines worth of JUST the defensive ammo.
Also, if you get Speer Gold Dots from http://www.miragetechnologies.net , they will only cost you $16 per 50 (in 9mm) which is only twice what I pay for WWB 9mm at WalMart. Pretty good price!!!
Great online site for ammo http://www.natchezss.com/index.cfm?C...TOKEN=61770599 Excellent service!!!
My current favorite carry ammo is DPX, at about a buck a pop, but hey, that was my choice, so I'll live with it, so to speak.
Speaking of expensive ammo. Back around 1994 or 1995, I bought a Para-Ordnance P-14 as my "Rodney King Riot" car gun. I could hardly wait to try it out. Drove out to the boondocks, found a safe backstop, and ripped off 14 rounds as fast as I could. Then I remembered that I had loaded the mag with Black Talons. Ouch.


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Leeroy Stagger Tickets
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Browse by Category
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Why Top Execs are Starting to Care About UX Design
Jesse James Garrett, who is a pioneer in user experience, sits down with Revolution to talk about why user experience deserves the attention of the c-suite.
OmniTouch – Touch screen for any surface
: Microsoft Research will unveil OmniTouch, a touch screen for any surface, at UIST 2012. Chris Harrison wrote about the research he did on the project. It is uncanny how simular this work is to MIT's SixthSense which I have written about back in 2009. : http://www.nickfinck.com/blog/entry/omnitouch_-_touch_screen_for_any_surface/
What is a UX Designer?
: Wonderful animated video about what it means to be a UX designer. : http://iatelevision.blogspot.com/2011/01/iluvuxdesign.html
Designing Through Adversity
: It can be fairly common for designers to come across adversity in their workplace, or at home in family life, but how do we continue to produce great work while working through the hard times. This video aims to provide 3 tips to help. : http://www.thisisaaronslife.com/designing-through-adversity/
The Value of Context in Design Pt. 2
: In this video I move on to the second part of the "The Value of Context" series, last time I wrote about how we can use context in our personal interactions, this time I talk about using context to rightly apply what we are learning from conferences, books, blog posts and our community. : […]
Andrew Maier of UX Booth talks content strategy
: Andrew Maier, co-founder and Editor in Chief of UX Booth joined me to talk about content strategy. Andrew has a wealth of experience in designing engaging websites and helping companies develop their content strategy to engage their audience. : http://www.founderbuzz.com/interviews/andrew-maier-of-ux-booth-talks-content-strateg/
Futuristic Online Sales uses Minority Report like style
: Instead of tirelessly skimming through endless static product lists, 3LiveShop lets you engage in a one-on-one video session with a sales rep. But instead of a dull Skype-like voice chat, the sales representative on the other end converses with the customer augmented-reality style via a multitouch screen. : http://vimeo.com/21968394
A day made of glass.. the future of displays?
: Watch "A Day Made of Glass" and take a look at Corning's vision for the future with specialty glass at the heart of it. : http://www.youtube.com/watch?v=6Cf7IL_eZ38&feature=youtube_gdata_player
Do Ask, Don't Tell: the Evolution of Succeeding Online.
: Although those of us who create for the internet have often been at odds with those who work in the search and social media fields, we need to embrace the bigger picture of how people actually use the internet today. We — and our clients — need to realize we are not the beginning […]
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Senior guard Brandon Price scored 21 points and junior forward Keon Williams just missed a double-double as the John Hardin Bulldogs pulled away from Johnson Central for a 74-50 win Thursday in the Republic Bank Holiday Classic at Lexington Catholic.
Price also had six assists and two steals, while Williams finished with eight points and 11 rebounds. Senior forward Daveon Greene chipped in with 12 points and seven rebounds for the Bulldogs (8-1), who won their eighth straight in a first-round rematch of last season's Sweet Sixteen – a game John Hardin won, 49-36.
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Wear what the coaches sport on the sidelines with the Scramble pullover jacket from Nike!
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Breaking Boundaries: A fresh start after Liberian civil warTonight, we bring you the second story in our three part series, Breaking Boundaries. We'll meet two men from the West African country of Liberia who now both live and work in Grand Forks.
Tonight, we bring you the second story in our three part series, Breaking Boundaries. We'll meet two men from the West African country of Liberia who now both live and work in Grand Forks.
After living through a civil war in their home country, Ebenezer Nyanswah and Melton Dadeah say they're both lucky to have a new start in America. Now, they're breaking boundaries ocean wide as they work to get much needed school supplies to Liberian children.
Ebenezer Nyanswah and Melton Dadeah were born in Liberia, but didn't stay long.
Ebenezer: "There was a civil war going on and my family and myself ran to a different country."
Melton: "I got chased out of my country when I was two years of age. I lost everything I had."
Both men escaped to the neighboring country of Ghana.
Melton: "We played soccer together, went to school together."
Several years ago, the childhood friends both ended up in Grand Forks.
Ebenezer: "It changed my life. People accept me for being here."
Melton: "We were so lucky to come to America."
Now, both men are working at a local tire shop and raising kids of their own.
Melton: "As a father you have feelings for kids. You have feelings for other people out there who don't have anything."
After finding some stability in America, the men decided to start the nonprofit Nyanswah Foundation to help educate children in Liberia.
Melton: "When we were growing up we never had anything, so we wanted to look out for kids back there."
Ebenezer: "Right now the economy is kind of tough back home. People have no jobs, so you have no money to send your kids to school."
Melton: "Anything that is not anything in America, believe me it's worth a lot back home to somebody."
Ebenezer's girlfriend is also helping out with the foundation. She says simple things like books and pencils are what's needed most."
Megan Gustafson: "People don't really realize that there's a lot of kids around the world that don't have that."
Ebenezer: I would love to help people. Since I was a little kid, that's what I always loved to do."
More information on the project including how to donate can be found at nyanswahfoundation.com.
Tags: breaking boundaries, reporter stories, kayla strayer, news, updates


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"The Composite City where all human potentials are spread out in a vast silent market… minarets, palms, mountains, jungle… a sluggish river jumping with vicious fish, vast weed-grown parks where boys lie in long grass, play cryptic games."
Yesterday's Twitter musing raised the idea of a GTA game featuring an old man: wandering the streets, smoking, reminiscing. This led me to suggest a Williams Burroughs game, "Interzone", where you battle the forces of control by distributing fucked up ideas across the city. So let's outline a design for Interzone.
"No narrative, all side quests," says Greg J Smith. That suits the Burroughsian idea, of course. And yet you can see how a Burroughs quest structure might work: a fragmentary mass of clues leading towards one inevitability. "The Old Writer would write himself out of death." The endgame would be immortality, access to The Western Lands, and you'd find your way in the city. There might not be a story – perfect for the random sandbox play of the city in which a player is wandering, exploring, struggling – but that doesn't mean there wouldn't be an ending.
"A ghost in daylight on a crowded street."
Visually the game world lands part way between Junkie and Naked Lunch. Part New York, part Tangiers. It's a familiar city, but there's something wrong with everything. Clearly the GTA city of Interzone would have to be far more tangled and jungloid than any game city we care to suggest.
"Our national drug is alcohol. We tend to regard the use of any other drug with special horror."
Two game mechanisms for Interzone.
The first is morphia: addiction. The Old Writer will have have to make contact with various individuals across the city so that he can stay in control of himself. The longer you go without a hit, the harsher visuals and audio becomes, the more complex interactions are. But one contact will run dry, you'll always have to search for another: following spectral junkies, looking for clues. Too long and you begin to lose control: the avatar wanders on his own, ravenous for junk. Eventually it's unplayable: too bright and grating to look at, too difficult to control. And yet you're facing a tricky kind of videogame resource management: take too much and you're fade out, overdosing, resetting to zero. Wake up in a bed in a dark room, sunlight through a single dirty pane.
"A paranoid man is a man who knows a little about what's going on."
The second mechanism is the Cut Up. You are constantly under threat of being captured: seized by agents of control. They only way to deal with it is to disrupt their activities, to keep them off your tail, dealing with other things. You distribute fucked up ideas to key locations. Pamphlets dropped off with key people, reducing the likelihood of the forces of control appear to deal with you. At higher levels you begin leaving tape recorders filled with subliminal messages running, an area-of-affect attack, context bombs. Parasitic upgrades.
The last resort – a thing of brutal finality, and your most limited resource – are the handguns that Burroughs loved. Just nine rounds in your automatic. Nine chances to escape control. Nine lives.
Cut word lines — Cut music lines — Smash the control images — Smash the control machine — Burn the books — Kill the priests — Kill! Kill! Kill!


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Parents of young athletes may expect the occasional bruise, scrape, or pulled muscle. But an injury to the anterior cruciate ligament (ACL) may seem a more likely concern for a professional running back or a slam-dunking hoop star. Yet millions of children every year suffer serious sports injuries, including torn ACLs.
A ligament is stiff fibrous tissue that holds bones together. The ACL is one of four ligaments in the knee. It connects the thigh and shin bones. It helps stabilize the knee, keeping it in place while you move.
Stretching the ACL or other ligaments too much can result in a partial or complete tear. Children may injure their ACL if they change direction quickly or land awkwardly after jumping. Blows to the knee area can also harm the ACL. Athletes who play basketball, soccer, and football are most at risk for an ACL injury.
Tearing an ACL can cause sudden pain. Your child may also recall hearing a popping noise and then feeling weakness in the knee. Other symptoms include swelling, discomfort, and limited movement. If you suspect your child may have injured an ACL, see a doctor immediately to avoid further damage.
To diagnose an ACL injury, your child's doctor will gently feel the knee and test it for range of motion and stability. He or she may also recommend an MRI test. An MRI provides detailed images of the knee's internal structure, showing the extent of the injury.
An ACL tear will not heal by itself. In general, ACL injuries are treated with physical therapy, limits on activity, a brace for added stability, or surgery. Treatment depends on your child's age and activity level. Children who want to return to sports will likely need surgery.
If your child isn't finished growing yet, surgery may raise your child's risk for bone growth problems. Experts are developing new techniques to avoid such outcomes. Talk with your child's doctor about all the benefits and risks of surgery. Keep in mind: Some studies have found that significantly delaying surgery may further damage the knee.
After surgery, your child will need physical therapy. Rehabilitation helps restore motion and strength to the knee. Many children recover within six months.
Always talk with your health care provider to find out more information.
Not all sports injuries-including those involving the ACL-can be prevented. But you can reduce your child's risk:
Make sure your child has a physical exam before joining a sports team. A physical can determine if your child is able to safely meet the sport's demands.
Enroll your child in organized sports groups that demonstrate a commitment to injury prevention. Check if they teach children how to properly pivot or land after jumping. That can help your child avoid an ACL injury. So, too, can strength training exercises for the knee.
Ensure that your child uses the appropriate safety gear-for example, helmets for football, shin guards for soccer, and good-fitting athletic shoes.
Make sure your child warms up and cools down before and after practices and games. Doing so can reduce the risk for muscle strains and pulls.
This video explains more about ACL injuries.
American Orthopaedic Society for Sports Medicine - Stop Sports Injuries
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In ShortBoomerangs, Aussie flags, kangaroo portraits and faux aboriginal art honor the homeland's wilderness, but Outback delivers a polished version of rusticity with varnished…
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Buffalo Wild Wings has an upbeat environment that just puts everyone in a great mood. The restaurant is a safe environment for parents to take their children, friends to hang out,…
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My wife and I really like this place and we eat here often. The food is alway good and fairly priced, the service is friendly and professional, and I like the decor. If you are…
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Yes one of the best family friendly restaurants I have dined in! ';o)
Call in order honest friendly staff..admits mistakes and fixes them.
1325 Rancho Vista Blvd, Palmdale
its really nice , we like to sit at the bar , NO WAIT! great cold beer, nice lunch specials ..i love the pan pizza & a ice cold beer make it a blonde!
853 Auto Center Dr, Palmdale
1233 W Rancho Vista Blvd, Palmdale
4013 E Avenue Q14, Palmdale
38241 30TH St E, Palmdale


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Wilton® Decked Out Christmas Village
Material List
- Wilton Cookie Sheet
- Wilton Cooling Grid
- Wilton Tips (2, 3, 4, 6)
- Wilton Icing Colors (Royal Blue, Brown*, Red-Red*, Christmas Red*, Golden Yellow, Kelly Green)
- Wilton Color Flow Icing Mix
- Wilton Sugars (Red, Yellow, White Sparkling)
- Wilton Lollipop Sticks (4 in., 11-¾ in.)
- Wilton 10 in. x 14 in. Cake Board
- Wilton Parchment Triangles
- Wilton Comfort Grip Christmas Tree Cutter
- Wilton 4-pc. Grippy Set
- Wilton 6-pc. Mini Metal Christmas Cutters Set
- Wilton Comfort Grip Candy Cane Cutter
- Wilton Comfort Grip House Cutter
- Wilton Star Cut Outs (medium size used)
- Wilton Rolling Pin
- Roll-Out Cookie Dough Recipe
- Ruler
- Scissors
- Waxed paper
- Cornstarch
- 1 in. craft block sheet (24 in. x 12 in.)
Project Instructions
In advance, prepare and roll out cookie dough.
Cut 3 Comfort Grip Trees, 3 Grippy Trees, 3 Mini Trees, 3 Mini Gingerbread Boys, 2 Comfort Grip Candy Canes (reverse one before cutting), 4 medium fondant star cut-outs.
Bake and cool.
Cover cookies, except stars and candy canes with color flow.
Use tip 3 and full-strength color flow to outline cookies and tip 3 and thinned down icing to fill in cookies; let dry on waxed paper covered boards.
For houses, use full-strength color flow and tip 2 to outline windows and doors.
Use tip 6 and full-strength color flow to pipe snow on roof and cover with white sparkling sugars.
Use full-strength color flow and tip 2 to fill in windows, doors and window on door.
Use tip 2 and full-strength color flow to pipe icicles on window sills and along bottom of house.
For candy canes, use tip 2 and full-strength color flow to outline red and white sections; let dry.
Use tip 2 and thinned down color flow to fill in red and white stripes on candy canes and immediately sprinkle with red sugars. Let dry on waxed paper covered boards.
For trees, make swags with full-strength color flow icing beginning at the bottom.
On comfort grip trees use tip 6, on grippy trees use tip 4 and on mini trees use tip 2.
Sprinkle all immediately with sparkling white sugars.
For stars, ice stars smooth with full-strength color flow; sprinkle with yellow sugars.
Attach 11 ¾ in. lollipop sticks to backs with full-strength color flow icing.
When dry, tie 24 in. curling ribbon on each stick and curl.
For gingerbread boy, use tip 2 and full-strength color flow icing to pipe dot eyes and buttons and outline mouth.
Attach 4 in. lollipop sticks to backs of cookies with full-strength color flow icing. Let dry.
Insert all pieces into craft block sprinkles with white sparkling sugar.


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Open House
Thank you to all who attended Open House on Saturday, March 29.
We hope you had a great experience. If you have any questions, please call the Admissions Office at 800-367-9222.
Details about our next Open House will be posted soon.
Don't miss this great opportunity to visit Penn College during the weekend.
Open House provides you the opportunity to:
- Meet faculty to learn more about our majors, which represent more than 100 different career areas.
- Tour our labs and classrooms to see for yourself how our state-of-the-art facilities and equipment can enhance your educational experience.
- Tour campus with a student ambassador and hear a student's perspective on Penn College.
- Attend a Choosing Your Major session to find out what career areas are a match to your interests and abilities.
- Tour on-campus housing and hear from students about what it's like to live on campus.
- Interact with current students and learn more about student clubs and organizations, athletics, dining services, and campus life!
- Save $50! Apply during your visit and your application fee is waived.
degrees that work.®
Learn about our programs of study leading to bachelors degrees, associates degrees, certificates, and competency credentials relating to more than 100 different career fields.
Can't attend Open House? No problem.
Schedule a
campus tour online
or by calling


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Hi everyone, my name's John, living and working in Racine, WI
I've been away from the political scene for a couple of months, I admit I let the 2008 election get to me. It's time though, for myself and countless thousands of others to start taking part in local and grassroots efforts. My goal is to have what effect I can on the 2010 General Election.
To that end, I've built a resource website for anyone looking to engage in conservative activism. The site is still small but growing, I hope you'll all take a look:
Thanks for reading!


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Welcome to Waterford
Home > > Pen & Desk > Pens & Pencils > Waterford Kilbarry Emerald Isle Ball Point / Capless Rollerball Pen w/ Chrome Accents
Superbly balanced, this Emerald Isle Capless Ball Point / Rollerball Pen is sure to be a treasured keepsake for many years to come.
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The Kilbarry Collection is named for the beautiful Irish parish where Waterford resides. The new Emerald Isle writing instruments feature a delicately engraved guilloche pattern on the solid brass barrel finished with multiple layers of rich translucent emerald green lacquer. The crown of the cap is engraved with the iconic Waterford deep-cut 'star' pattern. Adorned with chrome accents, the robust pens offer comfortable and well-balanced writing.
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Marquis Arcadia Pink Ballpoint Pen, Benefits Breastcancer.org
Waterford Kilbarry Emerald Isle Ball Point / Capless Rollerball Pen w/ Chrome Accents
Waterford Kilbarry Emerald Isle Capped Rollerball, Guilloche with Chrome Accents
Waterford Kilbarry Emerald Isle Fountain Pen, Guilloche w/ Chrome Accents
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Like the first day of school, the first few days of a new job can be absolutely nerve-racking. Among the butterflies of a new job, like what to wear or where to park, making a good impression probably tops the list of anxieties. Colleagues' opinions are often set early and can greatly impact your achievements at work. So, how can you set yourself up for success on day one? Here are four tips on how to make a good impression in a new job from four successful women.
More on Shine: 4 work mistakes you don't realize you're making
1. Be curious It's not enough to come early, stay late, dress nice, and act polite, says Kat Cole, Cinnabon president. "You don't stand out if you do that," she explains. "You do stand out if you're naturally curious, respectfully curious." She advises to ask questions and inquire why things are done a certain way.
2. Eye contact, a smile, and a good handshake "Brave" producer Katherine Sarafian explains that it seems so simple, but not enough people do it. "It's so easy to connect with people -- a little physical, a little eye, and a little voice," she says.
More on Yahoo!: Are you a job hopper?
3. Understand expectations Retired Four-Star Army General Ann Dunwoody says to let people know who you are and what your expectations are. Of course, it's also important to understand the expectations of your boss. Ann explains, "So there's no mistake in what your duties are going to be and what your success looks like for you in order to fulfill your boss' mission."
4. It's not about you On the first day of a new job, it's simply not about you. Mary Ellen O'Toole, an FBI profiler, says it's about the other people at the job and eventually, it will come back and be about you. She advises not to arrogantly walk into a new job, feeling entitled. "People don't like that," she explains, "and you are not going to have the opportunities that you wish you did 25 years down the road."
More on Shine:
Ann Dunwoody: Army's first female 4-star general
How to make it as a voice over artist
"Brave" producer on having no regrets


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Image courtesy of Bosch Fawstin. Visit Jihad Watch here.
CAIR is an unindicted co-conspirator in a Hamas terror funding case — so named by the Justice Department. CAIR operatives have repeatedly refused to denounce Hamas and Hizballah as terrorist groups. Several former CAIR officials have been convicted of various crimes related to [...]
Hamas-linked group that has publicized fake anti-Muslim hate crimes says anti-Muslim hate incidents rising in Minnesota schools
Image courtesy of Bosch Fawstin. Visit Jihad Watch here.


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Receivers & Amplifiers
Computer Expressions, Inc. Computer Expressions iPod nano Aluminum Case MP3 / iPOD Accessories
Protect your iPod while on the go! Product Information Your iPod nano is important to you, and the Computer Expressions Aluminum Cases for iPod nano (1st Generation and 2nd Generations) is designed to give you the protection you need from everyday wear and tear. Product Features Color: Silver Extremely Lightweight aluminum material Includes space for your iPod and earphones...


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I am a research scientist with expertise in cancer genetics, computational biology, and high throughput DNA sequencing technology. My research is focused on developing and applying methods to profile tumor DNA in order to characterize the genetic makeup of individual cancers. Knowledge of patient-specific genetic mutations can be used to predict patient outcomes and inform treatment options, ultimately enabling a more personalized cancer medicine.
With recent innovations in DNA sequencing technology, one can cheaply and quickly capture the relevant genomic information in an individual patient's tumor. In collaboration with oncologists, pathologists, and other translational researchers, I am leveraging the extensive institutional collection of annotated tumor specimens spanning all cancer subtypes to identify novel clinically useful biomarkers that may correlate with outcomes or predict responses to novel therapeutic agents. I am also working closely with the Diagnostic Molecular Pathology Laboratory to build a robust profiling pipeline for use in clinical trials and real-time patient management. Altogether, these activities aim to improve clinical practice by empowering oncologists to make treatment decisions informed by the molecular composition of their patients' tumors.
My email address is email@example.com.
Genomics and Computational Biology
PhD, Harvard University
The Broad Institute of MIT and Harvard


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The Pew Charitable Trusts is driven by the power of knowledge to solve today's most challenging problems. Pew applies a rigorous, analytical approach to improve public policy, inform the public and stimulate civic life.
Aug 22, 2008
Sunday morning August 10, the Washington Post offered readers a front page story about US swimmer Michael Phelps' gold medal victory in the 400-meter individual medley, the first of eight he would earn at the Beijing summer Olympics.
"There might have been a more spectacular and thoroughly dominant manner in which Michael Phelps could have begun his Olympics on Sunday morning," the piece began, "but that seems unlikely."
The following morning, on NBC's Today show from Beijing, Ann Curry reported on Phelps' second medal victory with a fixation on numerology. "In a country where eight is a lucky number, Michael Phelps' improbable quest for a record eight gold medals hinged on teammate Jason Lezak's anchor leg swim…By eight lucky and dramatic hundredths of a second, Lezak out-touched the trash-talking French, shattering the world record, and delivering Phelps his second gold of the games."
The mania only grew from there. And by the time the week was out, Michael Phelps would dwarf all other American athletes multiple times in media attention.
How has the U.S. press covered the Olympics Games? To what extent did the news media take the opportunity to cover the country of China while they were there? And how has U.S. coverage differed from that in other countries?
To get answers, the Pew Research Center's Project for Excellence in Journalism conducted a special analysis of coverage of the Olympics and China generally in the week leading up to the Games and during the first week of competition.
The study finds that the coverage has been heavily tilted toward just three areas of competition—swimming, gymnastics and track and field. No other sport has attracted much news coverage at all. The games were also dominated by a single athlete, Michael Phelps, with virtually no one else really emerging as a major figure, including the star female gymnasts.
Read the complete findings The Media's Olympics on the Pew Research Center's Project for Excellence in Journalism Web site.
The Pew Health Group's new Web site informs and engages people about issues that affect their health and well-being.
Spring 2012
Read articles on improving elections, the changing news environment, improving school lunch standards, and more.
The Pew Charitable TrustsTel: 215.575.4810 PATel: 202.552.2169 DCEmail: email@example.com
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The Combinations Search is a more powerful tool than the simple number search since it allows you to search
a combination of Powerball numbers as well as pairs, triads, quads, etc. That is, you can select a few or several numbers
to be checked. For example, you may select all even numbers to see if there were any past draws where all the winning numbers
were all even. Moreover, you may also select pairs or triads, such as 1-2, or 10-20-30. A more detailed instruction is given further down.
Although any match of the past results are listed, it does not mean that there are monetary rewards for matching them.
Since Powerball had undergone several matrix changes as well as prize structure changes, we cannot list prize amounts associated
with the matches. However, in most cases, only the 2 + 0 and 1 + 0 do not win anything while the others are
somehow rewarded. Click here for the most recent Powerball prize tables.
As stated in the Terms Of Use of this web site, we do not guarantee the accuracy of the data and results presented here.
Click on 1 to 30 Powerball numbers on the upper panel and 1 to 35
Power Ball (extra red ball) numbers on the lower panel.
If you have clicked on a wrong number, just click it again to unselect it.
Then click the "SEARCH" button. All the past winning Powerball numbers that match one or more of your selected numbers
will be listed in the "Results" panel. At the same time, the numbers entry panels will be cleared, ready to accept
another set of numbers.
The results will be listed in chronological order from the most recent to the oldest. To group the numbers by winning
category, click on the "List by winning group" button. This will list them into such groups as 5+1, 5+0, etc.
To switch back to chronological listing, click on the same button whose caption has now changed to "List by date".
Under the heading "Filter" are buttons that list the number of matches of each category. Click on these buttons to remove
the results of that category. For instance, you may remove the 2 + 0 and 1 + 0 matches since they are normally
not money winners. You may add back the removed items using the same button. This feature is especially useful for mobile
users which do not have the luxury of scrolling content containers.
Note that if you have played all the combinations of more than 5 regular and/or more than 1 extra ball numbers, each match
is also associated with more matches of the rest of the combinations. For example, if you have played the 112 combinations of
8 regular numbers and 2 extra ball numbers, and if you find a "4 + 1" match, then your 112 tickets would have 4 tickets matching
"4 + 1", 4 tickets matching "4 + 0", 24 tickets matching "3 + 1", 24 tickets matching "3 + 0", and so on. The detailed
associated matches are listed inside the right box of the above table.
Although you can use this tool to search just five numbers plus the extra ball, the simple
number search is better suited for that purpose. Also, you may generate your combinations with our
Combinations Generator.
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