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"Customer service is priority #1 at Rocky Mountain ATV/MC. We value our customers and strive to be the best shopping experience- when you buy from us, you are buying lifetime service."
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Comments On May 18, 2013:I had been using Scott goggles for a number of years and bought these on closeout. Good thing as they fit my face well and the lens is much more scratch resistant than the Scott's.
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Comments On Feb 16, 2013:Helps keep your roll off film from sticking to your lenses, along with the visors I have never had a problem with my roll off's failing. Great product!
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Still in 'the game'I read the story, A dream cut short, about former OU Women's Basketball Coach Beckie Francis – and my heart goes out to her. I had symptoms of Chrohn's disease (related to ulcerative colitis) when I was a student at OU. Bowel disease can be debilitating, especially for active people. Please tell her not to give up hope. There are still ways to make a contribution and participate in "the game" – at a different level. After four operations – trips to the Cleveland Clinic – I'm still doing the job I started as a student at OU in 1975, assisting students with their student employment needs. I credit OU with opening doors for me just as others were closing. Please forward my best wishes to Beckie.
Michelle L. Simmons, CAS '78Associate Director, Career CenterBowling Green State University
Comfort and HealingI read the article about the disease that former OU Women's Basketball Coach Beckie Francis and writer Ann Ruppenthal both have. I was absolutely thrilled to read the story, because I recently have been diagnosed with the same disease, ulcerative colitis. The article gave me some comfort knowing that I am not alone. Because I am so new to this disease, I also learned a bit from your article, such as stress makes you worse and rest is more necessary than ever if I ever want to heal.
Thank you to Ann Ruppenthal for writing the article and to Beckie Francis for letting her story be told. You both have changed my world, all because of one article. I was also happy to read that Beckie has a great faith in God. I, too, walk in faith and without my relationship with my savior, I would never believe in healing. Everything happens for a reason, especially when you are a believer. Thank you, thank you again. God bless both women. I will be praying for the recovery of you both.
C.F., SEHS '80St. Clair Shores, Mich.
Driving While BlackI read my wife Julie's OU Magazine and found some interesting and useful articles in it. I found the Driving While Black article very troubling, however. It seems to say that profiling by race/place is wrong or bad. David Harris' comments were the ones that triggered me. He talked about "...police hunting for black people..." and "the further away blacks are from black neighborhoods, the more pronounced this activity becomes." But such race/place is merely common sense and should be encouraged. Just as policemen should question why a black man is in a totally white area, they should question why I, a white man, should be in a totally black area. Of course, this does not mean they should stop either such person, but they should be checking data available to them to see if they can learn more. I feel that we need to work to eliminate racial prejudice wherever it exists, including strictly racial profiling by police. But race/place profiling is not racial profiling, and, as (Auburn Hills, Mich., Police) Chief Doreen Olko said in the article, "The study proves that more things come into play than just race."
David MarckiniWest Olive, Mich.
Colorful and AppealingI really enjoyed the winter issue of OU Magazine. As a Presidents' Club member, I have been getting publications for many years from Oakland University, but this is the first one that ever really grabbed me and said "READ." The layout was colorful and appealing and te content was varied and interesting. I found myself even reading Class Notes, and I'm not even an alum. I especially appreciated the article on Beckie Francis, A dream cut short. Women who achieve success have many difficult personal choices to make. Ann Ruppenthal's insightful article expressed that. Great job!
Nancy SergeantWest Bloomfield, Mich.


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January 2013
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adding picture.
this is crazy. I have used a standard hand snake maybe twice on this in past 15 years, never anything caustic and I can see finished room below's ceiling not a sign whatsoever of any problem.
1973 Build house. I replaced my toilet today. on removing the old bowl looking down past flange into the approx 3" pvc and just above the 90 degree curve, off to the side is an approximately one inch round hole clean through the pvc . looks clean cut. Toilet had been in use for 35 years several times a day with no leak and I would have seen as it is above a finished floor. I have had no recent plumbing or any work that could have cut into the pipe. Anyone seen such a thing before? is that some is of vent? Should I worry?
thanks for any informed thoughts on this.
adding picture.
this is crazy. I have used a standard hand snake maybe twice on this in past 15 years, never anything caustic and I can see finished room below's ceiling not a sign whatsoever of any problem.
That might be the vent line...
Jim DeBruycker
Important note - I'm not a pro
Retired Defense Industry Engineer; Schluter 2.5-day Workshop Completed 2013, 2014
cool thanks jadnashua. Have you seen anything like that before? like I said no sign of a leak from ceiling or rooms below below and that toilet has seen 20,000 -30,000 flushes by my calculations since I owned the place. It scared the living daylights out of me!
I would think that it is a side inlet closet bend, but the hole looks too small.
Check to see if if there is any flow in through the hole from one of the other bath fixtures.
I have seen a vent done with a San-T between the flange and the top of the closet bend (i.e. flange-pipe-SanT-pipe-closet bend). I haven't seen someone run the vent into the bend itself. From the photo, it seems to be at the crux of the bend, which would seem to present an opportunity for waste to accumulate in that line, which would seem to be nasty. Doesn't mean that somebody wouldn't try to do it that way, though.
Equally-likely, and equally-problematic, I think, is the suggestion that it might be a fixture drain.
It's hard for me to tell the sizing on that, and it seems to have an odd bend to it.
It does look to be cast into the fitting though.
I can't rule out a vent at this point. Normally those are 2", but in some places they can be 1.5"
Thanks for the answers. This bathroom is a powder room/half-bath and the sink is in fact to left where the hole is. I had installed the bowl last night to put a little water in it to avoid sewer gas. I have a one and a half bathroom place and was in the middle of renovating our full bath so this one leaking made me replace it right away.*
But I intend to renovate this half bath next month as soon as I am done with our full bath, I will be pulling the toilet out again and can test flow from sink to see if builder did some hack in 1973. I don't know what I will be able to do about it since I didn't plan to open the wall s below.
*the tank was leaking because I had a "gerber toilet nightmare" about a year ago. I had to remove the tank , got a new donut from the local hardware store and overtightened because I didn't realize gerber required a special larger non universal donut, casing in a hairline crack that now failed.
IT appears to be a 3 x 1 1/2" side inlet 1/4 bend. The photo does not give us anything to compare with so we cannot tell its actual size.
Licensed residential and commercial plumber


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Availability: Hapuna Beach Prince Hotel
Standard Room, Terrace
Standard Room, Partial Ocean View
Standard Room, Ocean View
Premium Room, Ocean View
Premium Room, Oceanfront
Suite, Oceanfront
Open-air beachfront hotel on Hawaii's Kohala Coast
VIP Access™ Hotel
We carefully hand-picked this hotel based on its dedication to service and excellent guest reviews.
At VIP Access hotels, Expedia Elite Plus© members receive free room upgrades and other perks upon availability at check-in.See details
Close to Waimea
Part of the 1,839-acre Mauna Kea Resort on the Kohala Coast of Hawaii's Big Island, Hapuna Beach Prince Hotel is flanked by 2 golf courses and is a 20-minute drive from Waimea.
Health spa
This Hawaii hotel offers a health spa, a large freeform outdoor pool with spa tub, and a fitness center.
Furnished lanais
Guestrooms at Hapuna Beach Prince Hotel offer bathrobes; high-speed Internet access (surcharge); and furnished lanais with garden, partial ocean, or full ocean views.Information missing or incorrect? Tell us!
Hapuna Beach Prince Hotel Amenities
- General
Located on the Kohala Coast of Hawaii's Big Island, Hapuna Beach Prince Hotel is part of the 1,839-acre Mauna Kea Resort. The hotel is a five-minute drive from both Kauna'oa Beach and Kawaihae Harbor.
This nine-story Hawaii resort has seven restaurants and bars, many with open-air terraces and ocean views. Cuisines include fresh local seafood, steak, sushi, and American fare. The clubhouse at the adjacent golf course houses a casual café.
For recreation, guests choose from a freeform outdoor pool; a fitness center with cardiovascular equipment and exercise classes (surcharge); and a health spa providing massage therapy, facials, and body treatments (surcharge). Several evenings a week, a high-powered telescope is set up for guests to stargaze, and an astronomer is on hand.
A year-round children's program (surcharge) includes Hawaiian arts and crafts, pole fishing, and beachcombing activities. On-site shops offer men's and women's clothing, jewelry, and art.
Guests have signing privileges and access to the facilities at the partner hotel Mauna Kea Beach Hotel, including a second 18-hole golf course, a weekly luau, and 13 tennis courts.
This is a smoke-free property. Valet parking and self-parking are available for a surcharge.
- Swimming pool - outdoor
- Poolside bar
- Full-service health spa
- Massage - spa treatment room(s)
- Steam room
- Sauna
- Spa tub
- Concierge desk
- Technology helpdesk
- Health club
- Coffee shop or café
- Breakfast available (surcharge)
- Restaurant
- Room service (limited hours)
- Bar/lounge
- Limo or Town Car service available
- Parking garage
- Secure parking
- Multiple small meeting rooms
- Ballroom(s)
- Banquet facilities
- Exhibit space
- Multiple large conference rooms
- Event catering
- Business center
- Computer rental
- Audiovisual equipment
- Cell phone/mobile rental
- Secretarial services
- Total number of rooms - 350
- Porter/bellhop
- Express check-out
- Security guard
- Multilingual staff
- 24-hour front desk
- Safe-deposit box at front desk
- Express check-in
- Beauty services
- Currency exchange
- Tour assistance
- Hair salon
- ATM/banking
- Shopping on site
- Dry cleaning/laundry service
- Laundry facilities
- Picnic area
- Patio
- Microwave in lobby
- Clubhouse
- Number of floors - 9
- Elevator/lift
- Golf course on site
- Self parking (surcharge)
- Valet parking (surcharge)
- Supervised childcare/activities
- Wedding services
- Babysitting or childcare
- Gift shops or newsstand
- Garden
- Designated smoking areas
- Airport transportation
- Tours/ticket assistance
- Tennis on site
- Parking limited (surcharge)
- Luggage storage
- Parking (surcharge)
- Smoke-free property
- Internet
Available in all rooms: Wireless Internet access (surcharge), Wired high-speed Internet access (surcharge)
- Parking
Parking (surcharge), Secure parking, Self parking (surcharge), Valet parking (surcharge), Parking garage, Parking limited (surcharge)
- Room Amenities
- Premium TV channels
- Pay movies
- Hypo-allergenic bedding available
- Lanai
- Air conditioning
- Phone
- Refrigerator
- Coffee/tea maker
- Bathrobes
- Complimentary toiletries
- Hair dryer
- Separate bathtub and shower
- In-room massage available
- Slippers
- In-room childcare (surcharge)
- Desk
- Iron/ironing board
- In-room safe
- Rollaway/extra beds available
- Cribs/infant beds available
- Complimentary newspaper
- Daily housekeeping
- Blackout drapes/curtains
- Wireless Internet access (surcharge)
- Wired high-speed Internet access (surcharge)
- Dining
Coast Grille - A lanai with ocean views surrounds the open-air dining room of this seafood restaurant, which emphasizes fresh local ingredients. Specialties include an oyster bar, lobster, and a seafood buffet on Friday evenings. Serving dinner only. Open Sunday through Tuesday. Resort attire.
Ocean Terrace - This casual, open-air restaurant serves breakfast buffets and à la carte selections. Open daily.
Beach Bar - Cocktails, early-afternoon pupus, sandwiches, and salads are served poolside.
Reef Lounge - Live Hawaiian guitar music accompanies sunset drinks on this open-air curved terrace.
Café Hapuna - Featuring takeout items including fresh fruit, sandwiches, picnic baskets, and coffee drinks. Build-your-own salad bar. Open from early morning until early evening.
- Recreation
Beyond the hotel's large freeform outdoor pool and spa tub, a pathway leads past a beach-activities desk to the half-mile crescent of Hapuna Beach. To the north end lies a secluded snorkeling cove. Designed by Arnold Palmer and Ed Seay, the 18-hole Hapuna Golf Course provides ocean views, a driving range, putting and chipping greens, a pro shop, and a fitness center.
The Robert Trent Jones, Sr.-designed Mauna Kea Golf Course is a five-minute drive from the hotel via complimentary scheduled shuttle. Guests also have access to a second fitness center and 13 tennis courts with pro instruction (surcharge) at the partner hotel Mauna Kea Beach Hotel.
The recreational activities listed below are available either on site or near the hotel; fees may apply.
- Parasailing nearby
- Helicopter/airplane tours nearby
- Sailing nearby
- Horse riding/rental nearby
- Tennis nearby
- Hiking/biking trails nearby
- Mountain biking nearby
- Scuba diving nearby
- Boat launch nearby
- Motor boating nearby
- Windsurfing nearby
- Bicycle rentals nearby
- Fishing nearby
- Playground nearby
- Aerobics on site
- Golf - driving range on site
- Golfing on site
- Pilates classes on site
- Rowing or canoeing on site
- Running track/path on site
- Snorkeling on site
- Surfing/boogie boarding on site
- Swimming on site
- Volleyball on site
- Whale-watching on site
- Yoga classes/instruction on site
- Accessibility
To make requests for specific accessibility needs, complete the "Special or Accessibility Requests" section of "Trip Preferences" when you book your hotel.
- Accessible parking
- In-room accessibility
Hapuna Beach Prince Hotel Policies & Fees
- Check-in
Check-in time starts at 3 PM
Minimum check-in age is 21
- Check-out
Check-out time is noon
- Payment types
Accepted at this hotel: American Express, Carte Blanche, Diners Club, Discover, JCB International, MasterCard, Visa
- General
Extra-person charges may apply and vary depending on hotel policy.
Government-issued photo identification and a credit card or cash deposit are required at check-in for incidental charges.
Special requests are subject to availability upon check-in and may incur additional charges. Special requests cannot be guaranteed.
- Fees
- The following fees and deposits are charged by the property at time of service, check-in, or check-out.
The above list may not be comprehensive. Fees and deposits may not include tax and are subject to change.
- Fee for in-room high-speed Internet (wired): USD 14.95 per 24-hour period (rates may vary)
- Self parking fee: USD 15 per day (in/out privileges)
- Valet parking fee: USD 20 per day (in/out privileges)
- Rollaway bed fee: USD 75 per night
- Details
Kids Stay Free
Children 17 and younger stay free when sharing room with parents. Valid for bookings and travel anytime.
Two adults and two children maximum per room booking. Must use existing bedding.


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A Book Lover
Design by Lim Heng Swee
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sola.jolaoso on Dec 16, 2013 at 18:38:41
Senanglynn on Aug 8, 2013 at 15:09:22
Swotty swotty!
baxtermonkey on Jul 24, 2013 at 14:22:16
I love and want this design SO MUCH...but I don't do bright colors. Dark grey? Hunter green? Navy?
HopeWish on May 3, 2013 at 16:28:34
Audrey.Eibye on Jun 16, 2012 at 00:10:10
girly size MEDIUM reprint PLEASE!!!
Celie1996 on Mar 18, 2012 at 22:18:18
Can you guys make this into a backpack??
brftigers on Feb 28, 2012 at 11:21:43
c'mon! no boys sizes?
peakei on Feb 24, 2012 at 17:36:51
i want the girly tee in Dark Kelly!
megarielang on Jan 5, 2012 at 13:42:40
I work in a library so this is me like every day of my life!!
ManaVing on Dec 29, 2011 at 13:02:59
That is COOL! When I do my sell books work, that's what I look like when I'm carrying a big stack of textbooks :-)
dejarnettg on Dec 29, 2011 at 12:32:28
Please make the girly sizes in dark kelly green!
eso456 on Nov 15, 2011 at 01:34:46
My sister just saw my shirt and wants one too, but there's no more in her size.
w1tbeyondmeasure on Oct 24, 2011 at 23:29:49
Please reprint!
sushiflowerful on Oct 12, 2011 at 10:26:52
I bought it some months ago, it's awesome! =)
sushiflowerful on Oct 12, 2011 at 07:13:38
I bought it some months ago, it's awesome! =)


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"It was an honor to participate." -- Dr. John Halamka, CIO
"For our patients getting coverage more quickly is a huge benefit."
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"Health IT provides the right information for the right patient at the right time."
--Seth Selkow, Director of HIE Engagement
"This initiative is growing."
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Partnering with Department of Defense on an Interagency Health IT Exchange
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Coffee Chain Opens in M.V. Core
MOUNTAIN VILLAGE – The Mountain Village Core is in the midst of a makeover, as the Hotel Madeline, one of its centerpiece properties, undertakes a new phase of development.
In a Jan. 17 press statement, Hotel Madeline announced new enhancements to the property, including new outdoor fire pits, improved outdoor seating at Smak Bar and a new entrance at Rev Restaurant, as well as new retail outlets – including a branch of Telluride Truffles, and the area's first Starbucks coffee shop.
"This is part of a series of improvements designed to make the Hotel Madeline and Mountain Village more of a year-round destination, and improve the experience of guests and locals alike," said Jim Mikula, managing director of Hotel Madeline Telluride and Inn at Lost Creek.
The most evident dimension of the development push comes in the form of four new retail outlets, all to be located on the ground level of the multi-story hotel complex located in the heart of the Mountain Village core.
The breezeway near Smak Bar Rev Restaurant, and the Mountain Village ice rink will soon be home to a new Telluride Truffles location; a new, yet-to-be-named gourmet food-and-wine shop, and the first Starbucks in San Miguel County. Palladin, an upscale boutique for U.S.-made furniture and decorating accessories, has already opened its sister location in that area of the Core.
According to Mikula, the retail expansion evolved out of a series of market analyses and reports compiled since the Hotel Madeline's most recent owner, Ektornet, purchased the hotel in the summer of 2011. The 2010 Mountain Village Comprehensive Plan also found that the expansion of retail outlets in the Core was essential to promoting economic growth in Mountain Village.
"Looking at those analyses, they all showed the Core needed more vibrancy and higher occupancy, and they specifically identified improvement of access to different types of food-and-beverage outlets," he said, explaining that the hotel used those studies as guides to creating the plan to fill in the currently empty retail locations.
The inclusion of a Starbucks in the retail expansion plan came as a direct result of Ektornet's "benchmarking" process, Mikula continued. "It all boiled down to attracting more visitors and business to the Core, and Starbucks consistently came up as a retail brand that could do that," he said, adding that the inclusion of local businesses, like Palladin and Telluride Truffles, was also important.
The Starbucks franchise will be operated by the Hotel Madeline.
Paul Slezak, owner of the Telluride Coffee Company, also located in the Mountain Village Core, said he isn't concerned that the new Starbucks location will dilute business for the coffee shop he owns, with his wife, Mary Ann.
"I think it's going to be good for us, because we'll stand apart as one of the only shops that doesn't do Starbucks up here," he said, pointing to the store's Colorado-roasted coffee, as well as its diversity as a breakfast and lunch café, as the business' strong points.
"We sell the best Colorado-roasted coffee in the valley as it is, so we're not too worried about Starbucks," Slezak said.
Mikula agreed that the retail expansion, slated for completion by this summer, will benefit Mountain Village as a whole.
"We have a responsibility to support the destination, and we want to help grow our local economy. So we're doing everything we can to increase the proverbial pie," he said.


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Attempts to silence the articulate voice of an ambitious young activist, author, and scholar is an affront to all who value the individual right to access the empowerment an education affords.
Urge current Secretary of State John Kerry to continue supporting young women's right to actively pursue an education without violence.
For Kakenya Ntaiya, education was the key to her own freedom and self-determination. Her dream of a better life as more than just a wife and bearer of children inspired her to return to her village and create a boarding school designed to educate young girls and save them from becoming child brides. Watch the video to learn more about Kakenya Ntaiya and her groundbreaking work for the Maasai girls of Kenya.


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Using an Infographic as a Press Release and Why Your Brand Should Try It
Attaching an infographic can help the media connect and gain a better understanding of your press release without having to read through the entire piece.
If your business is still wondering how it can better optimize its online presence to generate more sales online, a great option is to take a serious look at the benefits of conversion rate optimization.Read the Rest
Attaching an infographic can help the media connect and gain a better understanding of your press release without having to read through the entire piece.
Concept modeling can help even the most brilliant business ideas grow to the next level. This post shows the advantages of a concept model and how it can help.
As search engines become smarter, the emphasis for creating high quality content such as infographics has moved from SEO-based landing page copy to shareable content. Content creators, now more than ever, are rewarded for content that appeals to users, not search engines.
What is the role of a digital agency? Read this post to learn how digital agencies can supplement existing marketing teams and add more value to a business.
When targeting keywords in a blog post it is often easy to overlook the needs of your audience. This post gives you tips on how to write for for audiences and search engines alike.
Content Grouping can be a huge asset to any business if set up correctly. Read this post to learn how it's done.
If you haven't had the time to optimize your website, don't freak out. Use these 3 helpful SEO tools to get your website moving in the right direction.
Creating a valuable email marketing campaign can be a difficult task for even the most seasoned marketer. This post covers some email tools that can help make email marketing easier.


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My fiance and I took a mini-vacation at the Silver Lake sand dunes. This was the first time we had visited sand dunes as a couple, so we made sure to bring our dog along. Mattie, our Shetland Sheepdog, has never seen so much sand. After sniffing and sneezing like crazy, we took to scale the dunes. She climbed like a mountain goat going side to side. But she really enjoyed taking flight on her way down the steep slope of sand. We laughed a lot that day, making new memories. Especially when she was frantically searching and sniffing for grass to do her business on. (btw- She held it until we left the dunes.) Looking back at the pictures we took guaranteed the idea of going to Silver Lake again for a bigger vacation.
Airborne doggy!
By: mattiesmomSubscribe Channel: Pets & Animals Location: Silver Lake Sand Dunes, Michigan
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Cyclophosphamide With or Without Veliparib in Patients With Locally Advanced or Metastatic Breast Cancer
- Full Text View
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- No Study Results Posted
- Disclaimer
- How to Read a Study Record
This randomized phase I/II trial studies cyclophosphamide with or without veliparib in treating patients with locally advanced or metastatic breast cancer. Drugs used in chemotherapy, such as cyclophosphamide, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Veliparib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. It is not yet known whether cyclophosphamide is more effective with or without veliparib in treating breast cancer.
Estrogen Receptor-positive Breast Cancer
HER2-negative Breast Cancer
Male Breast Cancer
Progesterone Receptor-positive Breast Cancer
Recurrent Breast Cancer
Stage IIIB Breast Cancer
Stage IIIC Breast Cancer
Stage IV Breast Cancer
Drug: veliparib
Drug: cyclophosphamide
Other: placebo
Other: laboratory biomarker analysis
Phase 1
Phase 2
|Study Type:
|Study Design:
|Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Double Blind (Subject, Investigator)
Primary Purpose: Treatment
|Official Title:
|Sequential Phase I - Randomized Phase II, Double-Blind, Placebo-Controlled Trial of Cyclophosphamide Alone or in Combination With Veliparib (ABT-888) in ER and/or PR-Positive and HER2/Neu-Negative Metastatic Breast Cancer
- Recommended phase II dose of veliparib that may be used with metronomic cyclophosphamide [ Time Frame: 21 days ] [ Designated as safety issue: Yes ]The descriptions and grading scales found in the revised NCI Common Terminology Criteria for Adverse Events (CTCAE) version 4.0 will be utilized for AE reporting.
- Progression-free survival (PFS) according to Response Evaluation Criteria in Solid Tumors (RECIST) version 1.1 [ Time Frame: From first treatment day until objective or disease progression or death from any cause, assessed up to 6 months ] [ Designated as safety issue: No ]The PFS distributions of the two treatment arms will be estimated by the Kaplan-Meier method. Ninety-five percent confidence intervals for the Kaplan-Meier estimates will be calculated using Greenwood's approach. The log-rank test will be applied to compare the PFS distributions between the two treatment arms and the Cox Proportional hazards model will be fit to the data to estimate the hazard ratio.
- Clinical response (complete or partial response) according to RECIST version 1.1 [ Time Frame: Up to 24 weeks ] [ Designated as safety issue: No ]Clinical response and benefit rates in each group will be estimated by computing proportions and corresponding 95% confidence intervals. Rates will be compared between groups using the Fisher's exact test.
- Overall survival [ Time Frame: Time from treatment initiation to death, assessed up to 4 years ] [ Designated as safety issue: No ]Overall survival will be analyzed using standard survival analytic approaches including the Kaplan-Meier method and the log-rank test.
|Estimated Enrollment:
|Study Start Date:
|May 2011
|Estimated Primary Completion Date:
|May 2015 (Final data collection date for primary outcome measure)
|Assigned Interventions
Experimental: Arm I (cyclophosphamide, veliparib)
Patients receive cyclophosphamide PO QD and veliparib PO QD on days 1-21. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity.
Drug: veliparib
Given PO
Other Name: ABT-888Drug: cyclophosphamide
Given PO
Other Names:Other: laboratory biomarker analysis
Correlative studies
Active Comparator: Arm II (cyclophosphamide, placebo)
Patients receive placebo PO QD on days 1-21 and cyclophosphamide as in arm I. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity.
Drug: cyclophosphamide
Given PO
Other Names:Other: placebo
Given PO
Other Name: PLCBOther: laboratory biomarker analysis
Correlative studies
Detailed Description:
I. To determine the recommended phase II dose of veliparib (ABT-888) that can be combined with metronomic dose cyclophosphamide in patients with metastatic breast cancer. (Phase I) II. To determine if the addition of veliparib (ABT-888) to metronomic dose cyclophosphamide improves median progression free survival (PFS) compared with cyclophosphamide alone in patients with estrogen receptor (ER) and/or progesterone receptor (PR)-positive, human epidermal growth factor receptor 2 (Her2)-negative metastatic breast cancer who progressed on at least two lines of prior chemotherapy and one line of prior endocrine therapy. (Phase II)
I. To determine if the addition veliparib (ABT-888) to cyclophosphamide chemotherapy improves the response rate.
II. To determine if the addition veliparib (ABT-888) to cyclophosphamide chemotherapy improves the clinical benefit rate (defined as objective response plus stable disease for at least 24 weeks from day +1) III. To determine the survival in patients treated with cyclophosphamide alone and cyclophosphamide plus veliparib (ABT-888).
IV. To determine the adverse event profile in patients treated with cyclophosphamide alone and cyclophosphamide plus veliparib (ABT-888).
I. To determine whether the macroH2A1.1 and poly (ADP-ribose) polymerase 1 (PARP1) expression status in archival paraffin embedded tumor specimens from either the primary tumor or metastatic disease is predictive of clinical benefit with veliparib (ABT-888) plus cyclophosphamide.
OUTLINE: This is a multicenter study. Patients are stratified according to measurable disease (yes vs no) and ECOG performance status (0 vs 1 or 2). Patients are randomized to 1 of 2 treatment arms.
ARM I: Patients receive cyclophosphamide orally (PO) once daily (QD) and veliparib PO QD on days 1-21. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity.
ARM II: Patients receive placebo PO QD on days 1-21 and cyclophosphamide as in arm I. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity.
Patients may undergo peripheral blood mononuclear cells sample collection for correlative studies. Archived tissue from primary tumor or a biopsy sample from metastatic disease may also be collected.
|Ages Eligible for Study:
|18 Years and older
|Genders Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Phase I: Patients must have histologically confirmed breast cancer (MBC) that is HER2/neu negative (as determined by local pathology or reference laboratory), and have disease that is metastatic (stage IV [TxNxM1]) or locally advanced and not amenable to potentially curative surgical resection (eg, clinical stage IIIB-C) Phase II: Patients must have histologically confirmed breast cancer (MBC) that is ER positive and/or PR positive, and HER2/neu negative (as determined by local pathology or reference laboratory), and have disease that is metastatic (stage IV [TxNxM1]) or locally advanced and not amenable to potentially curative surgical resection (eg, clinical stage IIIB-C)
- HER2/neu negative disease (performed on primary tumor and/or metastatic lesion using commercially available/approved assay in local institutional or reference laboratory), according to American Society of Clinical Oncology (ASCO)/College of American Pathologists (CAP) guidelines
- ER/PR expression (by standard immunohistochemical assay) on primary tumor and/or metastatic lesion known, and classified as ER and/or PR-positive according to ASCO/CAP guidelines (including 1-9%expression)
- National Comprehensive Cancer Network (NCCN) guidelines recommend for metastatic breast cancer "…biopsy documentation of first recurrence, if possible, and determination of hormone receptor status (ER and PR) and HER2 status…."; therefore, histologic and/or cytologic confirmation of metastatic disease is encouraged whenever feasible, but not required; in some circumstances, histologic confirmation may not be feasible (eg, bone metastases not amenable to biopsy and elevated CA27-29 tumor marker); for patients who have had histologic confirmation of metastatic disease, it is required that the biopsy confirm that the metastatic tumor is ER and/or PR positive, and HER2/neu negative; for patients in whom biopsy confirmation of metastatic disease is not feasible, it is required that the primary tumor be ER and/or PR-positive and HER2/neu negative
- Measurable disease (Response Evaluation Criteria in Solid Tumors [RECIST] 1.1) or non-measurable disease, with measurement obtained within 4 weeks of registration
- Phase I: Patients must have received at least one prior chemotherapy regimen for metastatic disease Phase II: Patients must have received two or more prior chemotherapy regimens for metastatic disease, which must have included an antitubulin agent (eg, paclitaxel, docetaxel, vinorelbine, ixabepilone) and capecitabine; there should be at least a 4 week interval between the last chemotherapy dose and registration (one week for capecitabine, 2 weeks for weekly paclitaxel in the presence of disease progression), and the patient should have recovered from acute toxicity related to prior therapy; no prior treatment with veliparib or other PARP inhibitors (eg, BSI 201)
- Patients must have had progressive disease after at least one line of endocrine therapy for metastatic disease (includes relapse while receiving endocrine therapy); there should be at least 1 week interval between the last endocrine treatment for an aromatase inhibitor and at least 2 weeks for tamoxifen or fulvestrant
- Eastern Cooperative Oncology Group (ECOG) performance status 0, 1, or 2 (Karnofsky >= 60%)
- Leukocytes >= 3,000/mcL
- Absolute neutrophil count >= 1,500/mcL
- Platelets >= 100,000/mcL
- Hemoglobin > 9g/dl (per manufacturer recommendation)
- Total bilirubin within normal institutional limits (unless isolated indirect hyperbilirubinemia due to Gilbert's disease)
- Aspartate aminotransferase (AST) (serum glutamic oxaloacetic transaminase [SGOT])/alanine aminotransferase (ALT) (serum glutamate pyruvate transaminase [SGPT]) =< 2.5 × institutional upper limit of normal
- Creatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal
- Patients with a history of brain metastases are eligible if they have been treated with radiation and have stable brain metastases at least 3 months after radiation and must also be off steroids
- Patients must be able to swallow whole capsules and tolerate oral medications
- Women of child-bearing potential and men must agree to use adequate contraception (hormonal or barrier method of birth control; abstinence) prior to study entry and for the duration of study participation; being not of childbearing potential is defined as: (1) prior hysterectomy, or (2) no menstrual period for at least 24 months
- Ability to understand and the willingness to sign a written informed consent document
Exclusion Criteria:
- Patients who have radiotherapy within 3 weeks prior to entering the study or those who have not recovered from adverse events due to systemic agents administered more than 3 weeks earlier
- Patients may not be receiving any other investigational agents
- Patients with known brain metastases with active symptoms or requiring anticonvulsive medications, or steroids should be excluded from this clinical trial
- History of allergic reactions attributed to compounds of similar chemical or biologic composition to veliparib (ABT-888) or cyclophosphamide used in the study
- Evidence of complete or partial bowel obstruction or other unable to take oral medications
- Patients with malabsorption syndrome or other condition that would interfere with intestinal absorption
- Patients unable to swallow whole capsules
- Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements
- Pregnant (positive pregnancy test) or lactating women will be excluded from the study; also, unwillingness to use effective means of contraception in subjects with child-bearing potential will be excluded from the study; women of child-bearing potential must use two forms of contraception (i.e., barrier contraception and one other method of contraception) at least 4 weeks prior to study entry, for the duration of study participation
- Patients with active severe infection; known infection with human immunodeficiency virus (HIV), hepatitis B virus, hepatitis C virus, or severe concurrent illness will be excluded from the study; HIV-positive patients on combination antiretroviral therapy are ineligible
- Patients with a history of seizure disorder requiring antiepileptics who have had a seizure episode within the last 6 months
- Prior treatment with veliparib (ABT-888) or other PARP inhibitors (e.g., olaparib)
|United States, Connecticut
|University of Connecticut
|Active, not recruiting
|Farmington, Connecticut, United States, 06030
|United States, New York
|Albert Einstein College of Medicine
|Bronx, New York, United States, 10461
|Contact: Eleni Andreopoulou 718-904-2730 email@example.com
|Principal Investigator: Eleni Andreopoulou
|Montefiore Medical Center
|Bronx, New York, United States, 10467-2490
|Contact: Eleni Andreopoulou 718-904-2555 firstname.lastname@example.com
|Principal Investigator: Eleni Andreopoulou
|Maimonides Medical Center
|Active, not recruiting
|Brooklyn, New York, United States, 11219
|New York University Langone Medical Center
|Active, not recruiting
|New York, New York, United States, 10016
|Mount Sinai Medical Center
|Active, not recruiting
|New York, New York, United States, 10029
|Columbia University Medical Center
|Active, not recruiting
|New York, New York, United States, 10032
|Weill Medical College of Cornell University
|Active, not recruiting
|New York, New York, United States, 10065
|United States, Ohio
|Arthur G. James Cancer Hospital and Solove Research Institute at Ohio State University Medical Center
|Active, not recruiting
|Columbus, Ohio, United States, 43210
|Principal Investigator:
|Eleni Andreopoulou
|Montefiore Medical Center
No publications provided
|Responsible Party:
|National Cancer Institute (NCI)
|ClinicalTrials.gov Identifier:
|NCT01351909 History of Changes
|Other Study ID Numbers:
|Study First Received:
|May 10, 2011
|Last Updated:
|March 20, 2014
|Health Authority:
|United States: Food and Drug Administration
Additional relevant MeSH terms:
Breast Neoplasms, Male
Breast Neoplasms
Neoplasms by Site
Breast Diseases
Skin Diseases
Immunosuppressive Agents
Immunologic Factors
Physiological Effects of Drugs
Pharmacologic Actions
Antirheumatic Agents
Therapeutic Uses
Antineoplastic Agents, Alkylating
Alkylating Agents
Molecular Mechanisms of Pharmacological Action
Antineoplastic Agents
Myeloablative Agonists
ClinicalTrials.gov processed this record on April 23, 2014


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"List price" is the suggested retail price provided to us by our vendors. We make no representation that a substantial number of these products have been sold or offered for sale at the list price. Actual retail prices in your area may be substantially different. Since we sell products on a national basis, it is not possible to know if our merchandise is sold at list price in any particular location or at any particular time. "You Save" reflects the difference between our price and the vendor provided list price shown on our sites. Since the list price may be different than the actual retail prices in your area, you may not actually realize a savings of this amount.
Manufacturers sometimes ask that retailers not display a price if it drops below a certain amount. The "Click here to see Lowest Price" message indicates that the price of the item is so low that the manufacturer requested that it not be advertised (that is, displayed). In a brick-and-mortar store, you would probably have to ask a salesperson what the price of the product is. At eCOST, by clicking on "Click here to see Lowest Price" you are essentially asking to see the price, at which point we show it to you.
This portable and lightweight adapter rapidly charges your iPod, iPhone or PDA, mobile phone etc. It's the perfect travel companion for mobile users on the go. Cable not included.
6 Question(s) • 5 Answer(s)
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Rules and Regulations
Asked by Douglas McKenzie from OR | May 19, 2011
Flag as Inappropriate
Best Answer
If you read the terms of the rebate, you'll see that this is limited to one offer.
Answered by Matthew Booher from NV | May 26, 2011
1 Answers
Asked by James Bishoff from VA | Jun 26, 2011
This will technically work with any iOS device. However it's only 2.6 watts. (the specs show 5.2 volts and 500 mA = 2.6 watts). The iPhones and probably iPods get a 5 watt charger and the iPad gets a 10 watt charger. The old iPods got a 10 watt charger also.
The reason this is important is that it will charge any iOS device but half the speed or slower. And if you use the device while charging you may even see it discharge slowly! (I was using my iPhone 4S pretty heavy and it came with a 5 watt charger and it actually fell to 92% while in use!)
Bottom line, this charger is half or 1/4 the power of Apple's chargers.
Answered by Thomas Kelly from FL | Dec 29, 2011
Asked by Bessie Pantazis from NC | Jan 30, 2012
This will not work with an iPad.
Answered by Don Jerico Yambao from CO | Aug 06, 2012
Asked by Bruce Erickson from CA | Feb 04, 2012
Answered by Sangharsh Aggarwal from MO | Feb 07, 2012
Asked by Jessica Kuhlman from TX | May 19, 2012
Yes, you can fold the prongs.
Answered by Don Jerico Yambao from CO | Apr 24, 2013
Asked by Edward Szymoniak from IN | Oct 08, 2013
0 Answers
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No matter what your working environment is like, it is important that your computer is placed at a location and height that is comfortable for you to use. Desktop computer stands can provide the best in placement for your desktop computer, and can help you customize your computer's placement to suit your particular sitting position and eye level. With a proper desktop computer stand at your work or home office, you can maximize visibility of your computer screen and even improve the efficiency of your working conditions.
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With the growing emphasis on posture and seating position in work environments, a desktop computer stand seeks to alleviate some of the posture problems that many computer users suffer. Because they are adjustable, desktop computer stand positions can be altered to fit the needs of many different users, which is particularly useful if someone needs to share his or her computer. This flexibility makes a desktop computer stand a must-have for any work space that is shared by two or more people. But even if you are the only person who uses your computer, flexibility can still be vital for ensuring that your computer height is comfortable throughout the day.
Desktop computer stands can be utilized in a number of areas. They can be especially useful in areas such as:
All of these different settings could benefit significantly from the options that a desktop computer stand offers its users. At Beyond the Office Door, we aim to please each of our customers with a variety of desktop computer stand options, hoping to help them find their perfect desktop furnishing. This is why we emphasize flexibility and adjustability: we believe that our customers' comfort and overall health is one of the most important considerations in conducting our business.


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FORTUNE -- Say what you will about Uber's cocky founder, its surge pricing, or its shady drivers. From a pure investment standpoint, the car service startup has been golden.
Some back-of-the-envelope math shows why: Take Uber's $1.5 million angel round, led by First Round Capital and Lowercase Capital. It had a valuation of around $4 million pre-money. The company's later rounds had valuations of approximately $40 million for its Series A in 2011 and $300 million Series B later that year. Six months ago, Uber raised money from Google Ventures and TPG at a $3.5 billion post-money valuation. The company's revenues were around $125 million last year, which handily beat expectations.
The company's success is having a halo effect for its early investors, who seem to be having no trouble raising new funds. In investment meetings, limited partners are preaching the gospel of Uber. "Anyone with Uber in their portfolio is looking pretty good right now," one LP said.
In addition to First Round and Lowercase, that Angel round included backing from angel investors Mitch Kapor, Alfred Lin, Naval Ravikant, Babak Nivi, Cyan and Scott Banister, Shawn Fanning, Jason Calcanis, Mike Walsh, Oren Michels, and Josh Spear.
MORE: For CEO Nadella, signs of leadership potential
Shervin Pishevar was an early investor in Uber and later led Menlo Ventures' $37 million round in the company. He's used momentum on that and other investments like Tumblr and Warby Parker to raise money for his own fund, Sherpa Ventures. On Tuesday Dan Primack reported that Pishevar has held a first close on $87 million in commitments, beating its initial target of $60 million. The overall fund has a target of $150 million. One of Sherpa Ventures' limited partners is TPG, which also invested in Uber.
Techstars CEO David Cohen, who invested in Uber's first $1.25 million round, is in the market raising $150 million for his next fund (called Bullet Time Ventures 2014), according to an SEC filing from December. The new fund, his third, is a significant step up from his prior fund, a $25.6 million vehicle raised in 2012, and sources say he is nearing a close on the full amount. (Cohen declined to comment beyond the filing.)
Meanwhile, Founder Collective, which backed Uber's Series A, is currently investing from its second fund, a $70 million vehicle which closed last year. It is almost double the size of its first fund. And First Round Capital is slated to raise a new fund in the second half of this year.
If the company continues its current trajectory, the Uber Effect may become the new Facebook Effect. Recall that Facebook's early investors, including Jim Breyer, Marc Andreessen, Peter Thiel, Reid Hoffman, and David Sze, have been among the most successful investors for the past several years.
Surprisingly, given how close-knit the Silicon Valley investor community is, there's only one investor Uber and Facebook (FB) have in common: Goldman Sachs (GS). Update: Uber and Facebook actually have two investors in common. In addition to Goldman Sachs, angel investor Matt Ocko made early bets in each company.
|What stumps Warren Buffett? Minimum wage
|Water becoming more valuable than gold
|GM's $1.3 billion recall cost wipes out profit
|Will 7 Apples a day keep the bears away? - The Buzz
|Ex-Wal-Mart CEO Duke retired with $140 million


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Wide Width Skechers Bungee Ties Sneakers
was: $80.00
Designed to provide ultimate comfort with every stride, these running shoes feature bungee ties, cushioned insoles, shock-absorbent midsoles and wider width for a better fit. Working out has never been so comfortable!
You May Also Like
- upper: 100% leather; insole: synthetic; outsole: 100% rubber
- Imported
- Spot clean.


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The front end of the 2011 Dodge Challenger V6 Rallye
The 2011 Dodge Challenger V6 Rallye just screams muscle car.
The 2011 Dodge Challenger V6 Rallye just screams muscle car.
The all-new 2015 Subaru Outback wagon gets a number of new refinements that make it better than the old model it replaces.
Until now, AMS Performance has held the title as world's fastest, street-legal Nissan GT-R on the quarter mile.
On April 9th, Ford Motor Company launched a minisite with an electronic birthday card, asking fans from around the world to sign the card and help with the Ford Mustang a happy 50th birthday.
Last night at a media preview before the start of the New York International Auto Show, the Korean automaker introduced the seventh generation of the Hyundai Sonata to the American automotive media
The 2015 Toyota Camry was unveiled today at the New York Auto Show. The new car is completely restyled, though we have seen most of the design elements before.
2014 brought with it multiple voluntary recall notifications from American Honda Motors.This old-school motor-head visualized a red flag or two based on our past experience in the automotive indust


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Hort Update for the Week of March 18, 2014
|Major Symptom:
|1. Winter turf injury
|Winter conditions may cause damage to lower mowed golfcourse turf
|2. Spring mower maintenance
|Service mowers before beginning another season
|Trees & Shrubs
|Selection of well-adapted trees critical for success
|4. Emerald Ash Borer update
|EAB quaranties in Iowa, Missouri and Colorado
|5. Pruning deciduous shrubs
Use shrub's bloom date as a guideline for pruning
|Landscape Ornamentals
|6. Selecting summer bulbs
|Choose large, healthy bulbs for best growth
|7. Selecting perennials
|Helping gardeners choose; Right Plant Right Place
|Fruits & Vegetables
|8. Fruit cultivars for home planting
|Disease resistant cultivar recommendations
|9. Importance of cross pollination
|Good fruit set relies on cross pollination between varieties
|10. Promoting native bees
|Encouraging native pollinators will help ensure good cross pollination and fruit set
|11. Apple diseases
|Apple Scab and Cedar Apple Rust are two common issues on NE apple trees
|12. Planting vegetables
|Good planning and design as well as plant health will start your garden off right
|13. Nebraska frost dates
|Offers a guideline for when to plant outside in the spring
| 14. Repotting houseplants
|Spring is a good time to repot in a container about 1" larger than previous container
|15. Swarming ants
|Normal occurrence, positively ID to ease concern of termites
|16. English/Spanish language guides
|English/Spanish language guides available for the green industry
|17. Upcoming programs
|Eastern Nebraska Tree Care Workshops, March 18-26
|Made for iPod, iPhone, iPad, and Android systems.
Local Conditions
Dry conditions persist in Nebraska. Stay informed on current conditions, and public water utilities restricting water use. Visit UNL Drought Resources.
- Nebraska's local Soil Temperatures
- US Drought Monitor


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Gateway to the Garden Route
While this part of South Africa is not really considered a safari area, you will find great marine life and birds along the way, as well as some lesser-visited national parks that protect several unique habitats. Tstisikamma National Park is home to giant Outeniqua yellow-wood trees, ferns, rugged coastline, and colorful birds such as the Knysna lourie. There are also small coastal towns along the way such as Knysna, known for its oysters, and Plettenberg Bay, with its beautiful beaches. If you like multi-day hikes you must walk the Otter Trail and, for golfers, the Fancourt Hotel has three of South Africa's best courses designed by Gary Player - Montagu, Outeniqua and The Links. Come during July to October and be treated to the famed floral abundance that the area is famous for.
Activities at this Destination
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Adrenaline Activity
Enjoy a different kind of excitement on your safari. Choose from a wide variety of activities that will start your heart racing.
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Glide along the water in your silent, people-powered craft, getting a little closer to the animals before they hear you coming.
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Bring a Little of Africa Home
Bring home a piece of Africa, whether it's a small momento or an incredible piece of art that captures how you feel in this incredible environment.
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Mob storms Belfast City Hall over flag vote
DUBLIN — A Protestant mob stormed into the grounds of Belfast City Hall and clashed with police Monday night after the council voted to remove the British flag from the building for most of the year.
The Police Service of Northern Ireland said five of their officers and two security guards were injured during the hour-long melee outside city hall. The violence spilled into predominantly Protestant east Belfast, where passing Protestant crowds threw bricks and bottles at a Catholic church and hijacked a bus.
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- Officials confirm Alaska suspect killed Vermont couple
- Marine special operator awarded Navy Cross
- Veterans' gun rights become issue
- South Korea to reroute flights in rocket's path
- Egypt's crisis widens with planned march, strikes
- U.N. pulling staff from Syria; violence spreads near capital
- Mob storms Belfast City Hall over flag vote
- Israel defies critics in West over new settlement housing
- U.S. looks at military options if Syria resorts to WMDs


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Helena's annual Buck Creek Festival was, as always, a lot of fun this year. I'd like to thank everyone who came by the Davidson Law Firm "Official Sponsor" booth to visit as well as all the very hard working volunteers who make this event a success. Helena's festival has quickly become a highlight for Shelby County and just keeps getting better each year.
Just before the frog strangling rain came Saturday evening it dawned on me that perhaps some advice on drunk driving laws was in order. I'm not sure but perhaps our close proximity to the well stocked and popular beer booth was the inspiration for this week's article. Obviously, the first bit of advice is to not drive drunk! I would go so far as to say don't drive after having more than a few drinks as that very well might earn you a .08 BAC on the good old breathalyzer and 12 hours as a guest of the city or county. Simple enough yet around 15,000 Alabamians are arrested each year for DUI.
DUI's are also an enormous pain in the rear end. By rear end I primarily mean your wallet although there are significant jail terms possible with every DUI conviction. Here's what you get for your good time:
1st DUI – Up to 1 year in jail and/or $600 to $2,100 in fines and loss of license for 90 days.
2nd DUI – Five days to one year in jail and $1,100 to $5,100 in fines and loss of license for one year. The mandatory 5 days can be replaced with 30 days of community service by the Judge.
3rd DUI – 60 days to 1 year in jail and $2,100 to $10,100 in fines and loss of license for three years.
4th DUI – This is a Class C Felony. One year and one day to 10 years in prison and $4,100 to $10,100 in fines.
If you had a really good time and "blow" a .15 or more all of the minimum punishments are now doubled and you lose your license for one year. If you have a child under the age of 14 in the car with you all of the minimum punishments are doubled.
There will also be Court Costs, attorney fees and the costs of the mandatory court referral program that all add up to thousands of more dollars. In the City of Helena the court costs for a DUI are currently $540.50 and for a first time DUI in Helena I charge $1,000.00. You can see where this adds up very quickly.
On September 1st the new ignition interlock device laws will go into effect in Alabama and those that are convicted of a second or subsequent DUI, "blow" over .15, or have someone under 14 with them they will get the fun privilege of periodically blowing into a tube to keep their car cranked and running. I will write specifically on the new law in a later blog.
Lastly, there are a lot of myths out there about DUI's. They are almost all false. You can get a DUI for alcohol, prescription medication, narcotics or even medicines such as cough syrup and Benadryl. If you give a drunk person a lot of coffee and a cold shower you will only end up with a wired, clean, and cold drunk. Pennies, mints, mouthwash, and all the other assorted things people put in their mouths to try and throw off the breathalyzer don't work and could get swallowed (referring again to pain in the rear end). The only thing that brings sobriety is time.
The rule of thumb for an average person is to make sure you eat before consuming alcohol and only consume one beer or mixed drink per hour. I strongly advise waiting at least one hour after your last drink before driving if someone else cannot drive. There are few crimes that Courts and prosecutors have lower regard for than DUI. You are not only endangering yourself but everyone man, woman and child on the road with you. MADD's slogan is simple and true … "Don't Drink and Drive".


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Hallandale Beach police are searching for a man they say forced his way into a home with a six-foot wooden stick and then took part in a fight that led to another man's death.
Police say Frantzy Etienne, 29, forced his way into a home on the 300 block of Northwest Fifth Avenue in Hallandale Beach about 3 a.m. Sunday and was then involved in a struggle with three other individuals — one of whom fired a gun multiple times in self defense.
Macarthur Smith, 26, was shot in the torso and died. Maria Smith was shot in the left forearm and was treated and released from Hollywood Memorial Regional Hospital.
Etienne, who has a violent criminal past according to police, is described as a black male, 5-feet-8 to 5-feet-10, 175 pounds. Police believe he is living at 426 NW 143rd St. in North Miami.
He is facing charges of armed burglary, aggravated battery and murder.
The Hallandale Beach Police Department is asking anyone with information to call Detective Wissem Mejdoub at 954-457-1436 or Crime Stoppers at 954-493-8477. Any information leading to the suspect's arrest could receive a $1,000 reward.


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Can India become a global hub for innovation? Nirmalya Kumar thinks it already has. He details four types of "invisible innovation" currently coming out of India and explains why companies that used to just outsource manufacturing jobs are starting to move top management positions overseas, too. (Filmed at TEDxLondonBusinessSchool.)
pin This talk was presented to a local audience at TEDxLondonBusinessSchool, an independent event. TED editors featured it among our selections on the home page.
- Interactive transcript (20 languages)
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Guys to watch out for (internet tough guys):
Guys that know you are personally a coward despite never meeting you or holding a real conversation with you (psychic or stalker):
Tune in on Fridays at 12 noon for Sport-a-Facts with Ro Brown and Wednesdays at 1pm for Sports Revolution to hear me speak my mind on all things Saints and Pelicans related and more.
Only on WBOK 1230 AM.
Feel free to PM me for more details.
Didn't look too bad. It hurt like a mother f though, especially since it was the same ankle. If something popped, he wouldn't have been able to walk off. Monty even gave him a slap on the fact at the end lol, then Rivers walked off on his own power. I'd sit him for the first game or two and let that thing really heal up.
Did Vasquez just split defenders?
"Davis is gonna be the best Basketball Player Ever. ......Please quote me." -Silverfoxx
Vasquez does well in half-court. But full court offense ain't his strong suit.
I honestly thought Mike Miller's leg was going to fall off after last year's playoff run. Yet here he is.
"Every fight is a food fight when you're a cannibal."- Demetri Martin
Roberts should get a roster spot just for making plays like that
Since we took him never got a great hype about him. Hell, like Miller more than him as a pick.
WOW. How is Davis doing this? His hands are like Art Tatum's.
Is Aminu sleeping out there? He's letting Miller make open jumpers.
Davis is freakishly talented... Said everyone, ever.
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Sail On!
Poet Nikki Giovanni inspires Class of 2013 at 85th Annual Commencement
With poet Nikki Giovanni delivering the commencement address to a crowd of more than 4,000 on the University Quadrangle, UNC Asheville held its 85th annual commencement ceremony Saturday, May 11, celebrating the 730 graduates of the Class of 2013. Those honored included the 466 May graduates, the 243 students who received degrees in December, and 21 August graduates.
The Commencement Address
Known for her civil rights advocacy, Giovanni chose a surprising analogy for the graduates – young Christopher Columbus. Separating Columbus from controversy over explorers' impact upon the peoples they encountered, Giovanni imagined how his mother might have felt as he prepared to embark. "She brings tears to my eyes when I think about his mother because she knows one thing – if she sends her boy out, then she may never see him again," said Giovanni. "She's like a lot of parents who encourage their children: 'Go to college, go get a degree,' knowing, that if you fulfill that dream, they will not see you again. Or that the 'you' that they see will not be the 'you' that they saw. You will change. But our faith in our children requires that we send you out."
Giovanni then urged graduates to "sail on" like Columbus. "He knew that whatever was there, if he fell off the earth, it was better than turning back and saying 'I can't do it.' I come from a generation that could not say to our grandparents ... 'no, we can't do it, we can't change America, we can't stop the war, we can't make a more just world.'"
Columbus, said Giovanni, "found a new world, and the world was the world of his heart, that there was something to do that had not been done. And I'm saying to you this morning, Class of 2013, you too must sail on. There are issues needing to be resolved. You must sail into that new world. If you fall, if you perish, at least you tried to do something. You must sail on into all of the unknowns and make a better world for every one of us. You can do this ... You must. We count on you."
Giovanni, the author of some 30 books for children and adults and one of America's most widely read poets, is a University Distinguished Professor at Virginia Tech. She was presented with an honorary Doctor of Humane Letters degree by UNC Asheville Chancellor Anne Ponder.
Ponder also presented an honorary Doctor of Humane Letters degree to Asheville native Warren Haynes, the singer, guitarist and songwriter who first gained fame as a member of the Allman Brothers. Haynes has used his annual Christmas Jam concert to bring leading artists to Asheville and to raise more than $1 million for Asheville Area Habitat for Humanity.
After degrees were conferred, Ponder concluded by quoting a line from one of Giovanni's poems: "'A poem is pure energy.' That is how we, your family and friends, professors and all of us here at UNC Asheville feel about you, our graduates," said Ponder. "With great expectations, we send you, our newest graduates, out to make tomorrow's world a better place. We are so proud of you."
Faculty and Student Awards
For information about faculty and students receiving awards, and additional student profiles and photos, please see the news release.
A "Storify" sampling of commencment photos and posts is available onlne.


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Last weekend I attended Review Santa Fe, an annual juried portfolio-review event in New Mexico. A hundred photographers were selected to participate, and over the course of three days I met with twenty-five of them. I saw many exciting projects, in various stages of development, both in these reviews and at the open portfolio review night, ranging from fine art to photojournalism. Here's a small selection of some of the most impressive work that Review Santa Fe introduced me to.
- Laura El-Tantawy, from the series "I'll Die For You: Suicide in Rural India."
"This man is forty-year-old Jayavant Vitthal Bhalerao," El-Tantawy told me. "He is a farmer who committed suicide by consuming pesticide on July 28, 2009, due to failing crops and his inability to pay an accumulating loan." The photograph is part of a larger series that El-Tantawy has been working on for nearly two years about farmer suicides in India.
- Ayala Gazit, "Gabriel" (2008), from the series "You Don't Say."
This series, Gazit told me, "focusses on what is left unsaid in my family's history…. In this image, Gabriel, my youngest cousin, functions as a surrogate for my brother James, who I will never meet."
- Christopher Capozziello, from the series "The Distance Between Us"/AEVUM.
For the past ten years, Capozziello has been making photographs of a young man with cerebral palsy. Only recently did he reveal that his subject is his own twin brother, Nick. "Suffering raises countless questions," Capozziello writes. "From time to time, someone will ask if I ever feel guilty for ending up the healthy one. I do…. The hardest part of being Nick's twin is knowing that many of my experiences are outside his grasp. Yet he understands enough about the world around him to know what he is missing."
- Emile Hyperion Dubuisson, "Helicopter" from the series "Siberia, the Far North."
"I went to Siberia without a camera," Dubuisson said in an interview in Foam. "I bought one there. I was eighteen. Before going there, I had never photographed. After shooting these images, I did not photograph again for more than ten years. There was only one kind of black and white film available. When I processed the film, it was in the winter, so the water from the sink was very cold; half the film didn't turn out. The negatives were very thin and underdeveloped. I was so depressed. The film was practically blank, so I put it away for fifteen years."
- McNair Evans, "My Sister on Easter Morning" (2010), from the series "A Journal of Southern History."
"I made 'My Sister on Easter Morning' at our family breakfast," Evans told me. "Patricia and her husband are shown saying grace with our Mom's hand reaching into the frame. An original member of this prayer circle, I saw the lighting, passed Mom's hand to Patricia, and made this single image. Removing myself from the circle to photograph this intimate moment echoes the difficult balance of photographing loved ones."
- Tamas Dezso, "Peter," from the series "Here, Anywhere" (2009).
Twenty-six-year-old Peter holds a mangalitsa piglet at a breeding farm in suburban Miskolc, in northeast Hungary, one of the poorest regions in the country and in the European Union. He is one of the few men of his village with permanent employment.
"The map of Hungary is speckled with capsules of time," Dezsoin writes of this series, which records disappearing ways of life in his native Hungary.
- Alessandro Penso and Michele Palazzi, "Seasonal Workers Praying in the Field," from the series "Migrant Workers Journey" (2010-2011).
"Every year, in a sort of pilgrimage through Italy, around three thousand seasonal workers follow each part of the harvest of agricultural products such as melons, tomatoes, grapes, olives, and oranges, working for as long as twelve hours a day for only twenty-five euros," Penso and Palazzi write. "They live, or, better, they survive, in empty houses without electricity and water. They don't have any rights or any form of assistance."
- Dina Litovsky, "Untitled" from the series "Untag This Photo" (2010).
Litovsky shot "Untag This Photo" in "various New York City nightclubs, bars, and lounges over the past few years." The series, she told me, "takes a look at the intersection of the contemporary, Lady Gaga-esque exhibitionism with the viral explosion of digital cameras and social-networking participants, examining its effect on the social behavior and self-representation of women."
- Paul Kranzler, "Gregor Exercising His Show Horse Dusty Diamond, Ybbsitz" (2008), from the series "Brut."
Kranzler describes this series, which he worked on from 2004 to 2010, as an "extended family portrait." "So far it has been, for me, the most interesting work that I've done," he told me. "Suddenly familiar interiors, landscapes, and faces became tremendously new and also strange to me."
- Kevin Kunishi, "Nelita" (2010), from the series "Los Restos de la Revolucion."
This series, Kunishi told me, explores the legacy of the civil war in Nicaragua in the nineteen-eighties. "I met Nelita while living on the coffee cooperatives of La Fundadora in the mountains of Jinotega," Kunishi told me. "I rented out a small room in the back of her house for a few weeks. The morning I was to leave, we created this photograph on her way to the river to bathe." On another morning, Nelita told Kunishi her story over coffee. "I was working in a small market when I heard the first explosion," she said. "The Contras were attacking the village. They came into the house and dragged me into the woods."
- Chiara Tocci, "Dead Eagle" (2009), from the series "Life After Zog (And Other Stories)."
"The picture was shot in Theth, a village in the northern mountains of Albania," Tocci told me. "The family had captured the bird and stuffed it with salt. It was on the wall of their kitchen/living room. Albania is referred to as the 'land of eagles.' The eagle appears on their flag and symbolizes strength, power, and pride."
- Morgan Ashcom, from the series "West of Meigsico" (2009).
"Located in rural Meigs County, Ohio, a small anarchic community has developed over fifteen years on an eighty-eight acre property called Skatopia," Ashcom writes. "Founded by Brewce Martin, a forty-five-year-old skateboard pro, Skatopia has developed a reputation for the chaotic lifestyle of its residents and mayhem perpetrated by insiders on newcomers." This picture, he told me, "is of a man known around Skatopia as 'The Konvict.' He lived in a small corner of the property known as Fatty Hollow. At the time the photograph was taken he was a resident, but has recently fallen in love and left the community."


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Watch, Sekonda via ASOS. Rock-bead bracelet, Bijoubar via Boticca. Gold bracelet, JESSICA BARENSFELD hammered initials bangle via Vestiare Collective
Coat, CK (gift from mummy). Top, T by Alexander Wang. Boyfriend fit trousers, Uniqlo. Heels, Kurt Geiger Elsie. Bag, Valentino via Monnier Freres. Belt, JHYoo
Don't lean on the walls, they're wet! and made out of lego! (aka hopeful pieces of coding which I hope will endure the weather of the interwebz) It's my great pleasure to welcome you to the new layout of Park & Cube. After many months of extra-curricular hours scrubbing and hammering, here it is – not perfect but a lot of thought and work went into it, I really hope it'll grow on you. The new design has actually been up for over a week already – the period that I personally call hamster playground – so I also wanted to thank those kind, concerned folks who tested things out and sent feedback over that week.
Classic Blog View
I know many still prefer the straight-forward scrolling marathon – so I've made the Classic Blog Mode is available here: http://www.parkandcube.com/blog/, please feel free to access the blog through that link if you wish to skip a step. The reason for the change was because I was mostly feeling sorry for a lot of fun content that was being buried and forgotten in the archives, so I wanted to fish some out and re-share… but I won't be hurt if you're only calling to see what's new!
Click around doods, and if you'd be so kind to let me know what tickles you most my day would so be made.
Muchas thanks to Jen for being
photo-slave *whipcrack*
photo-slave *whipcrack*


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From The Plaza to Princeton
To those of you who joined us for Reunion 2011 - Thank you! It was wonderful to see so many of you enjoying the festivities at The Plaza Hotel in New York City. We hope the evening was a memorable one for you.
Our next alumni event takes us to Princeton, NJ, on Monday, June 13. President Stephen J. Friedman will host a Presidential Alumni Reception at the Nassau Inn. If you live in the area, take advantage of this opportunity to meet our president, network with your peers and to hear the latest news about your alma mater. Register online for this complimentary event at www.pace.edu/PANetPrinceton.
On July 19, we are pleased to invite you to 1 Pace Plaza for the next "InsideTrack with President Friedman" featuring a conversation with Jim Whitaker, the founder of Project Rebirth. Project Rebirth's mission is to chronicle living history and honor 9/11 victims and first responders, and to advance educational initiatives committed to pre-trauma resiliency building for first responders. This is the first of various events focused on the 10th anniversary of 9/11. Details will be available shortly.
We encourage you to check the online calendar at www.pace.edu/alumnieventcalendar for the latest information on upcoming events. Or, contact us at 877.825.8664 if you have questions about our events, programs or services.
iPace: Degree Completion Program
Pace offers a new degree completion program for people who are committed to finishing their Bachelor's degree, advancing in their career, and increasing their earning power.
> Read More
Marty McGuire Museum Opens
The Marty McGuire Museum opened at the Environmental Center on Pace's Pleasantville campus on April 25, 2011.
> Read More


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SoFi has proven integration capabilities with several 3rd party systems including SAP, Building Management Systems, SCADA as well as certain legacy systems for data input in up to 15 minute intervals. PE INTERNATIONAL and its partners offer various levels of integration support with energy metering and management systems. SoFi for enterprise energy management can also automatically import your utility bills for consumption and energy cost information in the absence of metered data or offer flexible questionnaire technologies for manual data capture
Understand the implications of your energy use in terms of primary energy consumption, resource depletion, exposure to fossil and nuclear power and many other indicators by leveraging extended regional and technology specific characterizations from our sustainability databases.
SoFi comes packed a wealth of energy performance assessment tools including its energy efficiency benchmarking platform with over 15,000 curated benchmarks from several third parties such as the US Department of Energy and our proprietary GaBi Databases for energy efficiency in production processes. Through our data on demand services, high-quality customized content can be delivered based on your specific benchmark requirements. The platform also helps you manage your own benchmarks and use them more effectively for performance analysis.
SoFi software for energy management enables detailed analysis of process energy and material efficiencies by integrating with our product and process sustainability software GaBi. Advanced modelling capabilities combined with tailored model content and live data allow you to analyze multiple scenarios simultaneously in order to find the most effective energy efficiency improvement measures.
Performance targets can be set at corporate, individual site levels or on suppliers against which improvement programs or actions are can be developed and managed. Actions can be evaluated using automatically generated cost abatement curves which display the cost-effectiveness of improvement projects along with their saving potential and can be used to find low-hanging fruit throughout your organization. The Best Practice Library is PE INTERNATIONAL's peer-based suggestion engine for improvement projects. The suggested actions are derived from several curated sources including the US Department of Energy, the German EPA and proprietary PE content and deliver sector and region specific implementation costs, success rate within companies as well as overall reduction for hundreds of improvement projects.
Advanced non-linear forecasting capabilities delivered through our Project Portfolio Planner can be used to assess future performance scenarios based on your targets and identified improvement projects enabling the development of actionable energy improvement plans, quickly and cost effectively.
Robert Gabriel


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On March 18 for lunch, the church is going to have a big bingo bash to raise money for our small team of folks who are going to Honduras this summer with the Church of the Incarnation. This effort is part of a plan that will eventually have us taking our own team to Honduras. Our folks going on this trip are continuing to learn about the process and get trained up so they can turn around and guide a trip on their own. We want to support them in this effort of partnership with the people of Honduras.
The Bingo Bash will be an opportunity to connect with other church members, have a lot of fun playing bingo, win some silly prizes, and support this important mission team as they prepare to do their work. It's $5 for your meal (taco salad bar) and one bingo card. Additional bingo cards are available for additional donations. Oh, and if you want some delicious dessert, that's an extra donation too! Haha! There might even be some special celebrity guests on hand.
Mark your calendars and plan on helping out!


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Safely save and store extras.
Made too much? No need to throw it out. You can safely save those extra helpings to serve another day, saving yourself time and money. Just follow these safety tips to keep your leftovers fresh.
Wash up.
Wash your hands well with soap and warm water before and after handling leftovers.
Don't let them linger.
Refrigerate leftovers within 2 hours of the time they were prepared. Remember to get restaurant doggie bags in the fridge within 2 hours of preparation, too.
Keep cool.
Cool food in the refrigerator instead of on the counter. Use a refrigerator thermometer to make sure your fridge stays between 35 and 40 degrees F. It is fine to put hot food in the fridge.
Divide and conquer.
Divide large amounts of leftovers between several clean, shallow storage containers.
Seal tightly.
Make sure storage container lids seal tightly, or cover them with aluminum foil or plastic wrap.
Give them room.
Place storage containers at least 2 inches apart in the refrigerator - this allows cold air to circulate.
Use it or toss it.
Use leftovers containing meat within three days, other foods within five days.
Small portions of leftovers cool down faster.
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About IC Intramurals
Intramurals is a fantastic way to get involved with your friends and peers in a fun, positive, and safe environment! We feature team and individual activities that engage you physically and mentally as well as opportunities to meet new people, create new friendships, and strengthen old friendships as well. We offer leagues and tournaments that appeal to different audiences, so be sure to check out what we are serving up for the year!
You don't need to practice every day or try out for intramurals either! As long as you are properly signed up, you are ready to go and have fun! We offer opportunities to create teams, or be placed on one as a free agent. Either way, there really is no excuse NOT to try us out!
For most activities, we offer a men's, women's and co-recreational division within the league Throughout the year, we usually run two or more activities concurrently and participants are able to play on a single sex team and co-recreational team for each activity. All intramural fliers will list the maximum number of teams which can be accommodated and the number of teams which will be accepted in each division. Once the division is filled teams will be waitlisted. Any division which does not completely fill then other teams will be added based on when their entry was accepted.
We also offer two different levels of competition within the divisions: 1) Pro, which is for those who tend to be more skilled and competitive and 2) Semi-Pro, which is for those who are less competitive or want a more casual experience.
The format for most team activities is a round robin schedule of five (5) games followed by a single elimination tournament. Every team makes the playoffs unless they forfeit two (2) games.
Indoor intramural activities may be played in Hill Center, the Fitness Center, or Glazer Arena in the A&E Center:
Monday – Thursday nights from 7:00pm – 1:00am,
Friday 6:00pm - 9:00pm,
Saturday 2:00 pm - 9:00pm,
Sunday from 2:00pm – 1:00am.
Outdoor intramural activities may be played on the Allen Fields, Emerson Field, Yavits Field, or Higgins Turf Field:
Weekdays from 4:00pm until dark,
Weekends from 11:00am until dark.
All playing times are subject to activity, semester, and availability.
Intramurals are popular!
Chances are, you know someone who plays intramurals here at Ithaca College! Around 20% of students take advantage of this program at least once during the year. You may have seen us in The Ithacan as well! We are also one of the largest employment entities on campus. We offer opportunities to learn about officiating as well as fieldwork placements within the intramural program. It's not just about having fun, but about learning how to create fun as well.
With an opportunity to decompress from your work, hang out with your friends, learn officiating skills and just plain old have fun, shouldn't you give us a shot if you haven't already?


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8,000 employees worldwide, around 70,000 products for various different textile production and joining methods, and a presence in over 150 countries: Since the year 1852 Groz-Beckert has represented diversity, precision and quality – and provided its customers and partners with comprehensive support along the full length of the textile value chain.
Find out more about the company, its products and its services – and also about the Technology and Development Center (TEZ)!
Magazin April 2014 online now!
Successful fiscal year 2013:
Sales rose to 568 million Euro!
Groz-Beckert at ITMA Asia and CITME 2014
The TexCar of Groz-Beckert
SEWING5: The new service conception of Groz-Beckert
Groz-Beckert Academy:
the training program 2014


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Joined 24th June 2008
Itswrite4u hasn't written a snapshot yet.
Go to Italy
Get married !
Buy a house
Finishing my degree
Getting more clients
Working on website for business
Staying organized
Nothing really...same as above
Answered on 25th June 2008:
Well, I am on the road to organization. Mopping, vacuuming and other cleaning duties are not too bad here. My son loves to help so he is the trash man. He takes out the trash and on trash pick up day, he rolls the green monster down to the curb. I have purchased a shredder so I can get started on shredding old mail and junk mail. If I can get that closet just right, I will be much better. LOL !
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Participate in This Event or find another event
Saturday, April 26, 2014
Depauw University Blackstock Stadium
313 S Locust St, Greencastle Map it
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Log in here
52 teams and 373 participants have raised $30,182.94
Total above may not reflect all participants, teams, and donations
Event Sponsorship Information Brochure
Important Dates:
Duck- Relay Benefit Date -December 3
Committee meetings:
*7pm unless noted*
December 4
December 11
January 8 (freshman & on-campus students)
January 22 (freshmen & on-campus students)
February 5
Team Captain meetings:
February 19
March 12
April 16
Community Relay For Life Kick-off:
January 15th from 6pm-7pm at Area 30
Your local American Cancer Society Relay For Life event is a great place to take action and fight back against cancer. The Relay For Life movement features community and campus events that offer an inspiring opportunity to honor cancer survivors, promote how individuals can reduce their cancer risk, and raise money to help end cancer. Today, with the support of thousands of volunteers, the American Cancer Society is helping save more than 400 lives a day. And we won't stop until we finish the fight! Sign Up online today and visit our Event Details page for more information.
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