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She'll love navigating cold, icicle-laden streets wearing this new down winter jacket with a sophisticated belted design. Constructed from a durable exterior that's treated with DWR (durable water repellent) finish, this winter-warrior is insulated with lofty 550-fill down for ample warmth needed during the coldest months. Quilted details offer a feminine touch and the faux-fur collar lining at the insulated hood is trimmed with detachable faux fur.
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Homocysteine is an amino acid that plays a role in forming the lipid plaques that clog blood vessels. It's newest use is as a screen for people at high risk for heart attack or stroke; for example, it may be useful in patients who have a family history of coronary artery disease but no other known risk factors.
Test Requirements
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CostThe cost of this test is $30.
Click here to review and print the Disclaimer and Consent form. Please bring these completed forms with you to your appointment.*
*Note: These forms are available as printable PDF files using Adobe Acrobat. If you do not already have an Adobe Acrobat Reader, download a free copy now from Adobe Acrobat.For detailed information regarding this lab test visit http://www.labtestsonline.org/.
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James Madison baseball will play its home opener hosting the Longwood Lancers on Wednesday afternoon at 4 p.m. at Eagle Field at Veterans Memorial Park. The game begins a span of 18 of the next 19 games at home for the Diamond Dukes.
In the first of two matchups this season, both squads will seek their first win with JMU suffering a pair of one-run losses at No. 35 Coastal Carolina over the weekend while Longwood had its series against Saint Peter's canceled. Sophomore left-hander Ben Garner will take the hill for the Dukes against veteran senior right-hander Kyler Morgan of Longwood.
During the opening weekend in South Carolina, CCU took the opener on Friday, 4-3, before Saturday's game was cancelled due to inclement weather. JMU had a ninth-inning rally for five runs in Sunday's contest, but it wasn't enough as Coastal came back to win in the bottom of the ninth with the aid of JMU fielding miscues.
Senior shortstop Casey Goss had a great weekend, batting a combined 4-for-8 (.500) over the two games with three RBIs and two runs scored. Also hitting over .300 was junior first baseman Matt Tenaglia (.375) and senior left fielder Colby Roberts (.333) who also hit an RBI triple in Friday's 4-3 loss.
In the two-game series, the starting pitchers couldn't find a groove, allowing a combined 10 runs. The relievers were able to stand their ground and keep the games close, pitching a combined 8 2/3 innings, allowing just two unearned runs on two hits.
JMU dropped its season opener for the eighth time in nine years with each of the last three losses (2010, 2012, 2013) coming against the Chanticleers. However, the Dukes will aim for their first straight win in a home opener while playing Longwood in the season's first home game for the second straight year.
Scouting Longwood
Longwood enters the game with a 0-0 record after their weekend series with Saint Peter's was cancelled due to inclement weather. Thirty-five year veteran head coach Buddy Bolding enters his last season as head coach for the Lancers returning six position players and six pitchers among his 13 returning lettermen. Longwood, which finished last season at 27-21, looks to start off on the right foot as the newest member of the Big South Conference.
Three of Longwood's returning lettermen include senior first baseman Justin Lacy, junior catcher Scott Burkett and junior shortstop Matt Dickason, who all played for and were All-Stars in the Valley League over the summer. Lacy enters his final season with a career batting average of .329, and has hit 16 home runs and 83 RBIs over his three-year career. Burkett has also had a stellar career so far, with a career batting average of .311, with 10 home runs and 69 RBIs.
As for the pitching, the Lancers will return senior right-hander Kyler Morgan, who finished last season with a 6-6 record and 3.87 ERA with 43 strikeouts in 74.1 innings of work. Longwood will also look to sophomore Aaron Myers to continue his solid work from the mound, as he finished last season with a 1-0 record and 3.38 ERA, while picking up five saves and striking out 48 batters in 45.1 innings of work.
Series History
JMU leads the all-time series 13-8. The Dukes won the first seven games in the series but has claimed just six of the last 14 meetings. In the most recent meeting last season in Farmville, Longwood left fielder Robby Newman hit a pair of home runs while five Longwood pitchers combined to limit James Madison to six hits in the 4-1 loss for the Dukes.
Starting Pitchers
Wednesday, 4 p.m.
JMU's Ben Garner (So., LHP) and LU's Kyler Morgan (Sr., RHP) will each be making their season debuts in Wednesday's game.


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Prepare and serve fruits, vegetables, cheeses, and hor d'oeuvres on this whimsical cutting board. The non-slip edging keeps it from sliding around during use. It can also be used as a decorative serving board.
- Material: Polypropylene
- Features: Reversible
- Care and Cleaning: Dishwasher-safe
- Dimensions: 12.5 " L x 10.0 " W x 0.33 " D
- Weight: 0.67 Lb.
guest rating


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By Malia Panzer (Author)
List Price: $16.99
Online Discount: 10%
You Pay Only: $15.29Catalog #: WSEP ISBN-10: 1578197678 ISBN-13: 9781578197675Binding: Paperback / Pages: 166Dimensions: 6 x 9 inches / Weight: 0.65 LBSPublished: by ArtScroll Mesorah PublicationsIn Stock?: YES
Malia Panzer, a young, vibrant wife and mother, never thought of herself as an especially brave person. Great spiritual might and physical fortitude belong to heroes, she believed, not to the ordinary person. But when Malia was told that she faced leukemia, the challenge evoked a strength she never knew she had.
To write this book, she had to relive all of the searing episodes of her long illness in her mind, and then select the salient moments to share with her reader. Though it was a painful process, she felt it was worth it - for the courage she found is so precious that it must be passed on to others.
Anyone who knows a victim of disease - or is, in fact, personally struggling with threatening circumstances - will be encouraged by the shining example set by this young woman. Malia speaks to us in her own words, without rancor, without self-righteousness and devoid of self-pity. Secure in her belief, she projects optimism and hope that shines straight into our hearts.
Most people will never experience the agonies Malia endured, yet through her valiant outlook on life, we are all better prepared for any challenge that may come our way.
Browse Related Books:Books > Stories > Stories - All
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One of the real strengths of Wisconsin Agriculture is its diversity. And that was on display in the Ag Products building at the Wisconsin State Fair. One of the more popular booths was that of the Wisconsin Honey Producers where the American Honey Princess was on hand to not only promote honey and honey products but also to inform consumers of the economic impact of the honey bee.
Copyright 2013 WFRV and WJMN Television Station, Inc.. All rights reserved. This material may not be published, broadcast, rewritten, or redistributed.


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Target Grants $20,000 to Continue Decade-Long Scholarship Program
July 21, 2011
For more than 10 years, the Target Corporation has been helping Native American students pursue a college education at tribal colleges and universities. This year, Target has renewed its commitment with a grant of $20,000 to the American Indian College Fund to continue the Target Tribal College Scholarship Program for the 2011-12 academic year.
"At Target, our local grants are making a difference in communities across the country," said Laysha Ward, President, Community Relations, Target. "We're proud to partner with the American Indian College Fund as part of our ongoing commitment to strengthen communities where our guests and team members live and work."
About Target


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Freeing the Soul from Fear
Robert Sardello - Author
Fear comes at us from politics, war, work, relationships, strangers, movies, and television. It keeps us from behaving intelligently, since the mind's first reaction to fear is to ignore danger, hoping it will go away. When fear takes over, it drives us to extremes of manic happiness or fits of rage; it pushes us to destroy relationships instead of letting relationships help us defeat it. When fear wins the battle, viciousness sets in, and we have miserable lives in a miserable world. Most important, fear keeps us from the one thing that could stop its taking over: becoming present.
Robert Sardello, an exceptionally powerful writer who Larry Dossey deems "one of the few modern thinkers who genuinely senses how to deal with the barrenness of modern life," argues that the soul's greatest enemy is fear. It is only when we can look honestly at every fear—from insecurity at work to existential angst—that we may fulfill its potential for kindness, love, and compassion.
This book is at once an inspiring manual for dealing with fear and a call to arms to change our situation and thereby change the world. It is a rich combination of theory, anecdote, exercises for strengthening the soul, and the wisdom of a great student of the soul.
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ASPCA volunteer Tamara B.'s beloved cat, Gypsy (right)
Here at the ASPCA, we're extremely grateful for the unwavering dedication of our volunteers. In just 18 months, volunteer Tamara B. has accrued more than 700 volunteer hours, assisting with numerous tasks—Hurricane Sandy relief, cat socialization, kitten syringe feeding and adoptions counseling, just to name a few. Tamara shared her story with us:
When I was asked to share my home with a feisty cat named Gypsy, I had no idea how my life would change or where he would lead me. I didn't know the term "animal socialization" then, and neither did he—I have the scars to prove it. Through trial and error, we found our way together and formed a loving, inseparable bond.
When Gypsy needed emergency care, I was referred to the ASPCA Animal Hospital. I was so impressed by the assistance and excellent medical care that Gypsy received; I knew I needed to do something to show our appreciation. I couldn't give a large monetary donation but I could give my time. I applied to become a volunteer.
No matter how busy your schedule, the ASPCA makes it easy for volunteers to make the minimum commitment. Once I began volunteering, I found I wanted to give more of my time. There are many different roles for volunteers, and it's a great learning experience. I started doing syringe feeding for young kittens that are still learning to eat on their own. No matter how stressful my work day had been, holding those little kittens washed that away. It was so rewarding to feed one of the little kittens, watch it grow a little bigger over time, and, while volunteering as an Adoptions Counselor, help that same kitten find a loving home.
Besides the great animals that I have met at the ASPCA, I have also met many wonderful people—the other volunteers, the staff and the adopters. I am honored to be part of this organization. My family and friends are impressed with my dedication, and Gypsy is proud of me, too.
Want to stay up-to-date on stories about ASPCA volunteers?
Sign up to receive our weekly newsletter, ASPCA News Alert - you'll receive important updates on what's going on and how you can make an impact to save animals' lives!
Spring is here! It's time to head outside for a breezy stroll through the park. We know someone who would be the perfect companion for warm weather outings: Finley! Finley is an energetic dog who loves every person she meets. She enjoys lots of play time and plenty of exercise.
This clever dog already knows Sit, and she'd love to have you teach her other tricks. Finley is looking for an active adopter who will spend quality time playing with her. She'll get along great with kids 10-and-up. Adopt Finley today!
Finley is available for adoption at the ASPCA Adoption Center. If you are interested in adopting please call our Adoptions department in New York City at (212) 876-7700 ext. 4120. To learn more about Finley, please visit her page.
Want to stay up-to-date on the latest ASPCA Pet of the Week?
Sign up to receive our weekly newsletter, ASPCA News Alert - you'll receive important updates on what's going on and how you can make an impact to save animals' lives!
ORANGE you excited?! Today is the ASPCA's birthday! That's right, the oldest humane organization in the Western Hemisphere is turning the big 1-4-8.
It all started when our founder, Henry Bergh, decided to speak up for animals in Civil War-era New York. After gathering signatures for his "Declaration of the Rights of Animals," Bergh was given an official charter to incorporate the ASPCA on April 10, 1866. Nine days later, the first effective anti-cruelty law in the United States was passed and, with a team of three, the ASPCA began working to enforce it. By the time Bergh died in 1888, 37 of the 38 states in the U.S. had passed anti-cruelty laws.
We have spent the past 148 years honoring Henry Bergh's mission "to provide effective means for the prevention of cruelty to animals throughout the United States," and we hope you will join us in celebrating. Hug your pet, don some orange, and help us blow out these 148 candles!
In New York City's parks, you'll see pet parents walking dogs of all shapes and sizes, ranging from tiny to extra large. And, while it might be hard to imagine larger breed dogs residing in small apartments, the truth is that super-sized pups can live perfectly happy and healthy lives as city dwellers.
Pamela Barlow, a Behavior Counselor at the ASPCA Adoption Center in Manhattan, says the key to cohabitating with a large dog in a small space is to provide your dog with plenty of exercise.
Now that spring is finally here, it's the perfect time to head outdoors. Large dogs can make great running partners, and provide motivation to hit the trail regularly for a vigorous run or walk.
This spring, please consider adopting a large breed dog from your local shelter—even if your home is on the small end of the spectrum. Check out our slideshow below of adorable large dogs available for adoption at the ASPCA Adoption Center, including the super-playful Romeo, sweetheart Baby, and the very friendly Ghost—just to name a few!
Not in NYC? Use our shelter finder to search for adoptable dogs near you.
We are happy to announce that the U.S. Senate Committee on Commerce, Science, and Transportation today approved the Prevent All Soring Tactics (PAST) Act, S. 1406, by voice vote. This important step paves the way for an eventual floor vote in the Senate.
The PAST Act, introduced in the Senate by Senators Kelly Ayotte (R-NH) and Mark Warner (D-VA), will amend the federal Horse Protection Act (HPA) to better protect horses from abusive "soring"—the practice of purposely inflicting severe pain in horses' legs and hooves to force them into an unnatural, high-stepping gait (walk). Specifically, the PAST Act will improve inspections at Tennessee Walking Horse shows, increase penalties for soring a horse, and ban the use of cruel "action devices," the heavy chains and stacked shoes that exacerbate the pain for sored horses.
A recently introduced "alternative" bill purports to address the problem of horse soring, but instead would have the effect of forever institutionalizing it. The alternative bill would do nothing to improve horse welfare—it would merely maintain the status quo. The ASPCA supports the PAST Act as the only Congressional bill that will make the reforms needed to end horse soring.
The PAST Act currently has 51 cosponsors in the Senate and 268 cosponsors in the House. We need your help to get this bill across the finish line. Contact your U.S. senators and representative today and ask them to support and cosponsor the PAST Act. On behalf of our nation's horses, thank you!


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Test opener says Sam Robson should be honored to play for Australia
If Sachin Tendulkar was turning 21 today, instead of 41, would he aim for ...
Tri-Series looms for players with an intellectual disability
Paul Fabrace joins Peter Moores in new system
Live streaming has ended for the 2013/14 season. Login to your Cricket Australia account to manage your password.
Never miss a ball with our free online radio.
Australia are ready to take on the world in Bangladesh, are you?
The Commonwealth Bank Southern Stars take their T20 form to Bangladesh.
Australia take on Pakistan for one T20I, three ODIs and two Test matches in the UAE.
Mitchell Johnson holds the record for the most wickets (37) in an Ashes series by a left-arm quick.
Brad Haddin has scored the most runs by an Australian wicketkeeper in a Test series.
Meg Lanning holds the record for the fastest 50 and century by an Australian female, scoring 50 runs off 23 balls and 100 off 45.
There's no better way to spend a day than with new friends learning how to play cricket. Join up today!
You don't have to bat or bowl to be in the middle of the action, become an umpire and join in on the fun!
Be in to win with all of Cricket Australia's current competitions
A website made for any and all young cricket fans. Create your avatar, play games and more!
Come join the Australian fans as they show their support away from home.
Left Hand bat
Left Arm Orthodox
Shaun Marsh is part of cricketing royalty in Australia, with his father Geoff, and brother Mitch, both playing for the national side.
Shaun has always been regarded as one of the most naturally gifted top-order batsmen in the country.
Marsh burst onto the scene with an incredible 2007/08 that saw him top the run charts in almost every tournament he played in. He led the way for WA in the ING Cup with 318 runs, while he accumulated 663 runs in the Pura Cup at an average of over 60. Marsh then went to India for the IPL, where his 616 runs at 68 saw him finish as the competition's leading run scorer.
Marsh was rewarded with a spot in the ODI side, where he dominated in the 37 matches he played. Eight half centuries and two big hundreds showed that he could handle the international stage.
A back injury saw him miss several months of cricket, and the injury seemed to affect him on the field, as he had a torrid time in Australia's series win against India in 2011/12.
17 runs at an average of just 2.67 made it hard for selectors to stick with the left-hander, and Marsh hasn't played since.
While he hasn't appeared in the Test side since 2012, Marsh has been working hard in domestic competitions to win his spot back.
The KFC T20 Big Bash League launched the second coming of Shaun Marsh. The 29 year old dominated the tournament, finishing with a staggering 16 sixes. His form for the Scorchers also saw him top the charts again with 412 runs at 58.86.
Marsh then backed up his T20 from with a fluent 155* (the highest score in his ODD career) against the Queensland Bulls.
Marsh is currently playing in the IPL for the Punjab Kings XI, where he has already produced scores of 77 and 73.
A prodigiously talented player who has what it takes to again don the baggy Green.
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Langer's tough love for Marsh
16 Apr 14
Five facts to back Shaun Marsh
31 Mar 14
23 Mar 14
Mitch Marsh chats to CATV after he nearly scoring a century on day three of the Bupa Sheffield Shield final, which NSW is in control of against WA.
Mitch Marsh speaks to the media after notching an unbeaten 92 for the Alcohol Think Again Western Warriors on day three of the Bupa Sheffield Shield final at Manuka Oval.
Test stars fined after reversed lbw
14 Mar 14
Marsh, Lyon fined for code breaches
16 Feb 14
Shaun Marsh spoke with CATV after the big win in Centurion, saying his return to Test cricket couldn't have gone any better.
'A long time to be nervous'
13 Feb 14
CricketAus Thank you. #LestWeForget http://t.co/GRODUHtiEH
CricketAus RT @ICC: Happy Birthday @sachin_rt - an exclusive film on his career is up now on the ICC YouTube Channel http://t.co/mK9PjexOoL
CricketAus RT @MitchJohnson398: Commemorate the ANZAC Centenary @CampGallipoli in 2015. http://t.co/sJXt4wm3Mu #anzacday #lestweforget https://t.co/TY…
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depfinder finds the dependencies of Slackware packages. The dependency list can be output to stdout, to a .dep text file without version information, or to a slack-required file with version information. depfinder is very fast; its speed is mainly due to the C++ code that is used in depfinder to find in which package each individual library is included. It also has support for running multiple jobs, which makes it a lot faster when used with multiple CPUs/cores. depfinder supports detecting dependencies of binary files compiled with languages such as C or C++ and it can also detect Python dependencies.
Comal-Linux is a Linux distribution derived from Slackware Linux. It is packaged as a live CD, and is intended for desktop users who want to use Slackware Linux without first installing it on their computers. Comal-Linux is built from "pure" Slackware Linux, making it as compatible with the original as possible, including application packages. By choosing lightweight desktop and application software, the distribution can be used on older computers. Comal-Linux is an unofficial Muslim edition of Slackware.
Slackpack is a package manager for Slackware Linux. It has a friendly GUI environment and can install packages, list installed packages, remove Slackware Linux packages (.tgz or .txz), and convert to .tgz format from .deb or .rpm. It can download Slackware Linux packages from package repositories, and can create .tgz packages from an application's source code.
Utopia is Linux distribution based on Slackware64. It includes Linux 184.108.40.206, OpenOffice.org 3.2.1, KDE 4.5.3, GNOME 2.30.2, Jackx, Audacity, VLC 1.2.0, Wine with patches to make Tomb Raider Underworld work, TigerVnc, Amule, Seamonkey and Icecat with Flash, Gammu with Wammu, Python 2.6, Gparted, Audacious, Testdisk, p7-zip 9.04, Nvidia drivers 260.19.12, Xorg 1.9.2, Java 1.6.0_21-b06, Filezilla, and more.
Twapake is a system administration utility for Slackware and Slackware-based operating systems only, making it easier to manage last installed packages and see the installation date of a package. It can print a simple list of N packages sorted by installed date to STDOUT. It can print a snapshot logfile to the /var/log/twapake/ directory. A snapshot is a list of all packages sorted by installed date at T time. The installed date is printed too, making it easier to see when a package has been installed on your system. You can remove the last N installed packages, print the packages installed since a chosen date, and launch a Curses User Interface for easy removal.
A database development and management tool for developers and administrators.
Perl based utility to extract formatted text content from MS Docx file


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Hydar Ali, Ph.D.
Graduate Group Affiliations
Contact information
346 Levy Building
240 South 40th Street
Philadelphia, PA 19104
240 South 40th Street
Philadelphia, PA 19104
Office: (215) 573-1993
Fax: (215) 573-2050
Fax: (215) 573-2050
Education:Permanent link
University College London, England, 1982.
Ph.D. (Immunology/Pharmacology)
University of London, UK, 1986.
University College London, England, 1982.
Ph.D. (Immunology/Pharmacology)
University of London, UK, 1986.
Description of Research ExpertiseResearch Interests:
Mast Cell Signaling in the Regulation of Allergic Diseases and Innate Immunity
Research Summary:
G protein coupled receptors (GPCRs) belong to one of the largest known groups of integral membrane receptor proteins. Not surprisingly, GPCRs have been exploited extensively for drug targets and their intracellular signaling pathways have been studied in great detail. Although it is well established that cross-linking of high affinity IgE receptors (FcRI) on mast cells and the subsequent mediator release leads to the pathogenesis of allergic asthma, emerging evidence suggests that mast cell GPCRs play an important role in modulating the disease process. The main research focus of our lab has been to delineate the pathways involved in the regulation GPCR signaling in human mast cells. In one project, we are interested in determining how C3a receptor phosphorylation by G protein coupled receptor kinases (GRKs) and the recruitment of adapter molecules (β-arrestins) regulate the activation of human mast cells. Our in vitro studies have clearly demonstrated that C3a receptor signaling in human mast cells are regulated differently by GRKs and β-arrestins than GPCRs that are expressed in many non-inflammatory cells. Currently we are using an adoptive transfer procedure to reconstitute mast cell-deficient mice with in vitro-derived murine mast cells expressing genetically modified GRKs and β-arrestins. These studies will allow us to determine how regulation of GPCR signaling specifically in mast cells modulates allergic diseases in vivo.
Surface epithelial cells, when activated by pathogen-associated molecular patterns (PAMPs) release small cationic antibacterial peptides (AMPs), known as defensins and cathelicidins. These peptides display potent antimicrobial activities, modulate immune responses, participate in angiogenesis and wound healing. In addition, they promote tumor metastasis and are implicated in a variety of chronic inflammatory diseases. Surprisingly, the cellular and molecular mechanisms via which these AMPs promote their diverse biological functions remain unknown. Recently, we made the unexpected observation that AMPs activate human mast cells via a new family of GPCRs (Mas-related genes; Mrgs) that are known to be selectively expressed in dorsal root ganglia. There receptors are not expressed in circulating white blood cells or tissue macrophages. Furthermore, there are no murine counterparts of human Mrg receptors. Most interestingly, we found that functions of these receptors are regulated differently by GRKs and β-arrestins than most of the known GPCRs. We are using both in vitro and in vivo approaches to study the regulation of these receptors. For in vitro signaling studies, we are utilizing primary human mast cells that natively express Mrgs and transfected human mast cell lines that do not natively express these receptors. For in vivo studies, we are using lentiviral transduction procedure to express human Mrgs in murine bone mast cells. Our plan is to adoptively transfer these murine mast cells expressing human GPCRs into mast cell-deficient mice. This approach will allow us to determine the role of human Mrg receptors in mast cells on allergic diseases and innate immunity.
Another focus of our research is to delineate the role of epithelial cell-derived cytokines on mast cell-mediated allergic diseases. These studies are based on the recent finding that a newly identified epithelial cell-derived cytokine IL-33, which activates a previously known orphan receptor ST2, and synergizes with antigen/IgE for Th2 cytokine generation in mast cells. We are testing the novel idea that the adapter molecule MyD88 is critical for the synergy between IL-33 and IgE for Th2 cytokine generation and allergic inflammation. For these studies, we are using retrovirus to transduce bone marrow progenitor cells with genetically modified MyD88 and to differentiate these cells into mast cells ex vivo. Our goal is to identify the motifs on MyD88 that regulates the synergy between IL-33 and IgE in mast cells. We are also adoptively transferring mast cells expressing genetically modified MyD88 into mast cell-deficient mice to determine how mast cell-specific modulation of MyD88 regulates allergic inflammation in vivo.
Selected PublicationsSubramanian Hariharan, Gupta Kshitij, Ali Hydar: Roles for NHERF1 and NHERF2 on the regulation of C3a receptor signaling in human mast cells. PloS one 7(12): e51355, 2012.
Gupta Kshitij, Subramanian Hariharan, Klos Andreas, Ali Hydar: Phosphorylation of C3a receptor at multiple sites mediates desensitization, β-arrestin-2 recruitment and inhibition of NF-κB activity in mast cells. PloS one 7(10): e46369, 2012.
Subramanian Hariharan, Gupta Kshitij, Guo Qiang, Price Ryan, Ali Hydar: Mas-related gene X2 (MrgX2) is a novel G protein-coupled receptor for the antimicrobial peptide LL-37 in human mast cells: resistance to receptor phosphorylation, desensitization, and internalization. The Journal of biological chemistry 286(52): 44739-49, Dec 2011.
Shenker Bruce J, Ali Hydar, Boesze-Battaglia Kathleen: PIP3 regulation as promising targeted therapy of mast-cell-mediated diseases. Current pharmaceutical design 17(34): 3815-22, Nov 2011.
Kashem Sakeen W, Subramanian Hariharan, Collington Sarah J, Magotti Paola, Lambris John D, Ali Hydar: G protein coupled receptor specificity for C3a and compound 48/80-induced degranulation in human mast cells: roles of Mas-related genes MrgX1 and MrgX2. European journal of pharmacology 668(1-2): 299-304, Oct 2011.
Subramanian Hariharan, Kashem Sakeen W, Collington Sarah J, Qu Hongchang, Lambris John D, Ali Hydar: PMX-53 as a dual CD88 antagonist and an agonist for Mas-related gene 2 (MrgX2) in human mast cells. Molecular pharmacology 79(6): 1005-13, Jun 2011.
Kashem, SW, Subramanian, H., Collington, S Maggoti, P, Lambris, JD and Ali, H. : G protein coupled receptor specificity for C3a and compound 48/48-induced degranulation in human mast cells: roles of Mas-related genes MrgX1 and MrgX2. Eur. J. Pharm. 668: 299-304, 2011.
Shenker, BJ, Ali, H and Boesze-Battaglia, K. : PIP3 regulation as promising targeted therapy of mast-cell-mediated diseases. Current Pharmaceutical Design Page: In Press, 2011.
Vibhuti, A., Gupta, K., Subramanian, H, Quo, Q and Ali, H. : Distinct and shared roles of β-arrestin-1 and β-arrestin-2 on the regulation of C3a receptor signaling in human mast cells. PLoS ONE 6(5): e19585, 2011.
Guo, Q, Subramanian, H, Gupta, K and Ali, H. : Regulation of C3a receptor signaling in human mast cells by G Protein coupled receptor kinases. PLoS ONE 6: e22559, 2011.
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Last updated: 07/03/2013
The Trustees of the University of Pennsylvania
Last updated: 07/03/2013
The Trustees of the University of Pennsylvania


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Thank you all for your prayers and whishes. I am sure your energy will contribute.
Just one question. I was just reading about curcumin ( curcuma plant ) as being very beneficial in anti-inflammatory processes. Also used at the dogs ( but not in arthritic symptoms ) but in cancer preventing symptoms. I wonder if anybody of you have experience in curcumin treatment. According to readings it could be added to regular food ( possibly probiotic enriched because of possible constipations side effects ) but your experiences are valuable to me. The resseller at which I ordered Samento droplets ticnture is also selling Curcumin tincture. So I wonder what would be the optimum for use as daily supplements perhaps as exchanging with Samento tincture used synergy effect of combination? My questions is if the Herxheimer or die-off effect when Samento or antibiotic is initiating process of mass bacteria strains to be killed this amounts of necrotized cells are then washed from the internal organs to the only safest place for toxins and rest of bacteria JOINTS. So it is like some hiding last hiding place. This information is valuable to me so that I can know if I am ont the right paht when there is stronger arthritic attack maybe this is not catastrophe but goldie's body is just cleaning and we should consider better way to wash the joints from the internal. What I am wondering now is there any way beside the methods you mentioned: acupuncture, radiation bone marrow therapy to cleanse the internal space between joints tissues and cells that are responsbile for regenerating the joints? Guess the body is capable of own regeneration but how to help him?
My Samantha had clinical Lyme disease at 1.5 years and clinical anaplasmosis at 7.5 years. Both times,she rapidly responded to doxycycline. She is 10.5 years now, and perfectly sound... Maybe looking further into other causes of polyarthropathies?
Janice and The Celebration Gang -
"Samantha, George, Tiki, Emily, Mick and Basil" Gone but not forgotten, Sally(Windjammer's Ima Country Girl CDX CGC), Laney(Mandell Marlenes Celebration UD RA CGC), and Cookie(Starseeker's Kissmas Cookie CDX RE CGC).
I was not talking about radiation bone marrow therapy.
There is another bone marrow therapy but I don't really know what it involves, my surgeon who performed my Golden's orthopedic surgeries suggested it. I will have to do some research on that.
Anyway, I know nothing about curcumin, so I cannot help you with that.
Pain meds, I was talking non-steroidal anti-inflammatories such as Rimadyl, Metacam to give your golden some relief.
I know nothing about herbal therapies or homeopathic remedies.
There are also Adequan injections, which help lubricate the joints, it is like the glucosamine/chondroitin supplement but injectable with faster results.
I hope your vet will be able to get to the bottom of your dog's problems and finally be able to help him, good luck and Merry Christmas.
My boys from left to right:
Thunder Dachsi Toby
My Toby, my heart dog 3/12/2003 - 3/30/2013, I miss you Toby!
Thunder March 2001 - 2 January 2014
Ivan, I am so sorry, I wrote the wrong thing. I did not mean bone marrow therapy I ment 'stem cell' therapy. My mind was elsewhere.
The surgeon was talking about stem cell therapy for my dog with arthritis.
So sorry!
My boys from left to right:
Thunder Dachsi Toby
My Toby, my heart dog 3/12/2003 - 3/30/2013, I miss you Toby!
Thunder March 2001 - 2 January 2014
We looked into stem cell therapy for a client's dog... I believe up here, Tufts would do it, but it was extremely expensive.
Janice and The Celebration Gang -
"Samantha, George, Tiki, Emily, Mick and Basil" Gone but not forgotten, Sally(Windjammer's Ima Country Girl CDX CGC), Laney(Mandell Marlenes Celebration UD RA CGC), and Cookie(Starseeker's Kissmas Cookie CDX RE CGC).
Yes, that is what I heard also and a bit invasive from what the surgeon said.
He was mentioning another procedure, not as costly and it involved drawing blood, spinning it down and taking parts of it and injecting it into the affected joints. I cannot remember what he called it and which part of the blood is re-injected.
My boys from left to right:
Thunder Dachsi Toby
My Toby, my heart dog 3/12/2003 - 3/30/2013, I miss you Toby!
Thunder March 2001 - 2 January 2014
Hello everybody,
Grateful for your support. Blessings for all your familly members and neighbours and certainly for your
goldies. My frined goldie Tim is doing better. But it seems he has problems with mobiltiy in waves. Today we made first longer hike into the forest. To me this was revelation because we were such a goodd team on hiking to mountains and really miss him with me. But today I felt so great while picking stinging nettle and hike for the first time in the forest.
So what is the issue now how to improve his status with up and downs and arthritic waves. Seems there are periods when I can feel cracking in his front legs while massaging him and his slowly walking. But there are days his energy is like in old times. Just feeling have a lot of reserves for imrproving his status. So what is the deal now:
1. He receives regularly each day ( twice per day droplets of Samento ) exchanging with Banderol droplets ( one month first sort, second month another one )
2. Receives dog pills that contains MSM+vitamin C + glucosamin + chondirtin
Now we are the point where decision has to be made for make next step or just stagnate in current
status that is very unstable and afraid if stagnation could return to worsening.
Received several suggestion to make some change and next level of improving or making better:
Please your help is most valuable:
1. Royal Jelly ...
I was told that bee's fresh royal jelly could enrich his body immune system
Is that true, I have no experience with royal jelly for dogs.
Me personally was intaking years ago but only as recovery as ultramarathon and
once when I was agraid to got sick for tick borne viral meningitis ...And at that time
helped me. So this time wondering about dog's support for royal jelly...
2. One lady here in my region told me she got advanced with her pet dog with cellfood product protocol
starting with oxygenaton....
3. I was adviced curcumiin( turmeric ) for joint inflammation
but i am not familiar with side effects specially on liver
what were your steps after first step of recovery?
Welcome back, I am glad that your dog is not really worse off.
Are you still giving the salmon oil? That is something that can be given daily.
I am not familiar with the effects of turmeric and by Royal Jelly, are you speaking of honey?
In your earlier posts, there were recommendations for dosing the Doxycycline, did you ever figure out if you got this particular antibiotic and at the correct dose?
I have had major arthritis issues with my Toby, not tick disease related though. I had pursued laser therapy and wanted to try acupuncture. Sadly, Toby got worse, was diagnosed with cancer which explained his getting weaker and passed away 8 weeks ago. We never got to try acupuncture.
Have you checked into any treatments that might help like the cold laser therapy, acupuncture?
Do you have any possibilities of letting your dog swim? That would help with muscle mass building without being a strain on the joints.
Anyway, good luck, keep us posted.
My boys from left to right:
Thunder Dachsi Toby
My Toby, my heart dog 3/12/2003 - 3/30/2013, I miss you Toby!
Thunder March 2001 - 2 January 2014
Dear Christa,
Very sorry for Toby.
I can not imagine the pain when you loose soul mate in dog. I am sure he fuflilled and someway still fulifilling your live and lives of your familly mambers ad neighbours. Whish you to overcome the pain and resides in your best dreams as guide and happy his soul was on common train with your Life.
Let me once more go through your check List.
First of all to get the information from the VET what antibotic he was given at the first therapy.
Acupuncture guess it is good idea. But got to check in my region if anyone is offering this service for the pets.
Royal jelly is not ordinary bee honey http://en.wikipedia.org/wiki/Royal_jelly.
But it is made strictly by bee workers for bee queen and baby bees. It does not have so much sugar and more enrich with amino-acids ...The problem is that in my region now is the season possible to get fresh royall jelly that is more bioactive than liofilized or other conserved forms. And this season will last only to the start of the summer. So need to quickly react if this is potential for even smaller releif and benefit.
For human ( I tested on me for inflammations after longterm physical extreme efforts and also in boreliosis case at human is helpfull ) it is very helpfull for inflammation and cells recovery specially for immune system. When considering dogs it is just need to know if there are any possible side toxic effects. Guess not but it would be good to be sure. And another one...which is little more difficult.
At the human it is much more helpfull if it is dosed under the tongue and be left there for a minute because this way it is directly absorbed to lymph and blood. How to proceed this with Goldie? No chance? But guess if this could be helpfull than any way is good for absorption than not to dose him.
|anaplasmosis , food supplements , homeopathy , joint stiffness , lyme disease
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The Gamecocks spent all of last week trying to exorcize the demons of that lopsided loss, but it was only after their 31-16 victory Saturday could they tell if they had been successful.
There is still some growing that needs to be done, but JSU coach Jack Crowe said his team took a step forward against the Redhawks.
"The thing I took away from last night was we grew up on the defensive line a little bit … and offensively we were efficient," Crowe said Sunday. "Those are the two things we weren't against Eastern Kentucky.
"I'd say we learned something. It wasn't something we didn't know before, but something we were reminded of that we'd better focus on and we did get focused on it and we got the results.
"That was one challenge. We accepted the task and went through the work and on that day we met the challenge. Every week it's going to be a new challenge. Whether we step up and take on the task of that week, both as coaches and players, will be seen over the next seven Saturdays."
The Gamecocks went from giving up 51 points to giving up only 16 – six in the second half. They went from not being able to develop a running game to rushing for 268 yards in a balanced attack. DaMarcus James ran for 149 yards and two touchdowns, and quarterback Marques Ivory enjoyed near perfect passing efficiency.
The challenges immediately going forward will be much different than the Gamecocks (2-2, 1-1 OVC) faced last week and conceivably daunting for a team that has struggled defending the pass.
SEMO was a power option team that lived on the run, so the 56 yards passing the Gamecocks held them on Saturday is somewhat misleading. Over the next two weeks, the Gamecocks will face two of the three most prolific passers not only in the OVC but the country.
It starts Saturday at Tennessee Tech, which has beaten the Gamecocks the last two years. Tech quarterback Tre Lamb ranks seventh nationally in passing yards this week, eighth in yards per game, seventh in passing efficiency, 16th in total offense and 25th in completions per game. His most dangerous weapon is Tennessee transfer Da'Rick Rogers.
As if the Golden Eagles (2-3, 0-2) weren't troublesome enough, the Gamecocks go to Eastern Illinois the following week.
EIU's Jimmy Garoppolo threw for 453 yards on Austin Peay Saturday, with five touchdown passes of 50 yards or longer. No need to clean your touchscreen - 453 yards is correct. He ranks second in the FCS in points responsibility, total offense and passing yards, while ranking third in passing yards per game and fifth in completions.
JSU is ranked 71st in pass defense, making a big jump after Saturday's showing, and 119th in pass efficiency defense. The Gamecocks still don't have an interception.
"I don't think there's much of a chance of us not recognizing this unique challenge," Crowe said. "It's not a continuation or extension of any of the previous games – any of them -- even if you go back to Tyler Wilson and Arkansas. It's a different kind of passing game … and you can't totally simulate it in practice."
In the interest of balance, the Golden Eagles are wounded. They are fighting through a rash of injuries, have lost three in a row and are coming off a 70-35 beat down by Murray State. They've given up 174 points in the last three games.
Al Muskewitz covers Jacksonville State sports for The Star. He can be reached at 256-235-3577.
Sports Writer Al Muskewitz: 256-235-3577. On Twitter @JSUSports_Star.


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Rizzo brings an attitude to every game — the right one
PITTSBURGH — The Cubs have a new tactic, and so far it's working. They have decided to try leading every inning because that's a lot more fun than being behind every inning, as it seemed they were a year ago.
Phil Rogers
April 2, 2013


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This started out as a post in the Fetish forum, but I think I got so wrapped up in the memories that it lost its place in that thread with too many details. Here it is again for those who might not ever find the other thread.
Wearing a buddy's socks after one was used to wipe up our cum was how I got my first sexual experience involving a sock. I had already begun to fixate on them once junior high started and I began changing for gym next to my best friend, and in order not to get caught checking him out (or worse yet, pop a bone)l I would always keep my head and eyes aimed down at the floor, where I had no choice but to notice his feet and how his white crew socks hugged each toe so perfectly, and how they always seemed so new and tight compared to my much less-frequently replaced tube socks. When I would think about him during jack-off sessions, oftentimes he'd still be wearing those socks because that was the most detailed mental image I had of his body.
Fast forward 2.5 years to my first circle jerk (sadly my best friend never took the bait for any of those) and our house rule of shoes coming off at the door suddenly exposed some more teen feet, clad in socks, to my eyes. In order for everybody to have a good look at the porn mag I'd found, we sat cross-legged in a semi-circle on the floor of my bedroom, first with hands in undies, then at my behest, the undies slid down our three pairs of skinny, hairless legs and formed pile behind our circle.
I'm still amazed that neither friend ever mentioned how much I ended up looking at them jacking rather than the magazine, maybe because I was too engrossed to notice them doing the same. Anyhow, I came first, a few short spurts that barely cleared my socked ankles, and while I excitedly watched my friends finish themselves off, the thought occurred to me of what was to be done with the boyjuice dotting the linoleum, as the kleenex box was empty and I didn't want to be spotted traipsing off to the bathroom for a washrag with no handy excuse why. The problem solved itself though when the last guy to cum didn't shoot far enough and ended up with most of it on his sock. We all went "ewww" (even I hadn't thought of cum + socks as sexy yet) and he asked to borrow a pair of my socks to wear home and for me to hide then dispose of the now soiled pair. I agreed, as I did to most suggestions at that age, and told him that he should just use the cummy sock to wipe up the other two loads off the floor while he was at it, then stash them behind a box in my closet.
Strangely I didn't think much of our shared masturbation experience the rest of the day, our time together being otherwise quite ordinary, playing basketball in the driveway and tormenting my little brother and his friends. It wasn't until I crawled between the sheets that night that I remembered the socks in my closet, noticing a very faint smell of strange boyfeet still in the air. Thinking back to the thrill of not just seeing my first hard dicks but also seeing guys I had yet thought of sexually shoot their cum suddenly mandated my hand sliding into my boxers around my straining cock while I padded over the linoleum towards the closet to retrieve those socks, my foot actually sticking on a spot which obviously hadn't been wiped very well. Socks in hand I quickly got back in bed, boxers around my thighs, cock in hand and running my fingers over the socks, looking for any dampness that could be our boycum.
Finding it, I began to explore it with my fingers, trying to find each spot and thinking about which of us it might be from based on how it felt soaked into the material. I didn't want to smell the sock itself, thinking of my friend's unsavory foot odor now more distinguishable in the air, but I brought my fingers to my nose several times, seeing if I could smell the familiar bleachy scent of my own cum or discern any different smells from theirs. My fingers just ended up smelling like his sweaty feet so I kept them on top of the comforter at arm's length while my other hand (the left, even though I'm right-handed) went to town on my stiffy. Normally I'd lift the covers above my jacking hand to keep the precum from staining the sheets, but with my other hand busy exploring that one slightly cummy sock I could already feel a wet spot forming on the top sheet. Pausing momentarily, I realized I still had nothing handy for cleanup and didn't want to just toss the covers off me in case someone should barge it before I finished.
Not wanting to stop playing with maybe the hardest boner of my life thus far, I clutched that cum sock and dragged it under the covers with me, arranging it folded with the crew cuff under the sock itself, heel at the root of my dick, the toe and ball of the foot area (where most of the cum could be felt) pointing up to my ribcage. My right hand making the familiar tent in the covers, my other hand was flying up and down like every night for the last year and quickly brought myself over the edge as I almost silently shot a few good ropes of boycum out the end of my dick. The first shot went past the musty sock entirely, landing just below my nipple, so quickly I grabbed the toe of the sock, feeling a wet spot already in it and moved that wet spot over the smear of cum under my nipple, and kinda shivered at the feeling. The rest had landed neatly on the sock so with a quick wipe at my now puckered foreskin sticking past the tip of my shrinking dick the sock emerged from the covers in my hand, quickly joined its mate and flew under the bed where I hoped it would air out and become undetectable.
The morning arrived with no such luck, and there was no time to find a better hiding spot for them so nobody else would find another guy's smelly socks tucked in my room somewhere with crusty cum spots on one. I just wanted to get them back to my friend and away from my snooping family, so reluctantly I put them on my own feet, grabbed my longest pair of pants so my parents wouldn't see and slipped them into my sneakers. They felt awkward and a little disgusting, not at all soft like I was used to socks being like in the morning. I remember one crusty spot ended up situated over the knuckle of the big toe on my right foot, and I couldn't stop moving it in my shoe, feeling that spot as it moved against my skin. My friends took the bus but I got dropped off right before school, so I'd have to wait for hours in his socks until I saw him halfway to lunch. By the time I saw him at his locker, I was definitely ready to give him those socks back, and just prayed he had my socks to give back to me.
Luckily he did and we surreptitiously placed each pair of socks in the other's gym locker as they slid off our feet while changing for P.E. When we got back to the boys locker room and I put them on my feet my socks felt so much better, and I was surprised to feel a little turned on at how they were still a little warm. I watched to see if he would put his on, but apparently wearing his gym socks home was preferable to wearing our stale cum sock. I didn't say anything and with a regret I carry to this day, never mentioned those socks to him again. I did wear the socks I got back from him to bed uncharacteristically that night, turned on at the thought of his feet having been inside them like mine were now, and thinking that seemed sexy since sex was all about things going inside other things. I rubbed out another load like always that night, except once the mess was made, I reached down and pulled a sock off my foot and used it to wipe myself clean like the night before, hoping it would tingle again and be exciting, and it was!
Thus a fetish was cemented in a teen boy's mind, leaving in its wake a trail of crusty socks belonging not just to me, but every cute guy I could convince to share them with me, and occasionally pilfer from floors or hampers of new crushes over the years. Now it's one of my favorite feelings, wiggling my toes in a sock with cum, fresh or dried, remembering how they represented sex to me before my penis got anywhere near anyone else's holes. It morphed into a love of footjobs too, or rather sockjobs, as to this day nothing really turns my crank like white socks on a guy's feet when his hard-on is in view too.


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Hope you can provide some guidance here for a couple of picky parents. We have a toddler son named Corin Henry, last name sounds like Hollis-with-a-W.We love his name and we like that most people can say and spell it with little prompting, but it's different from most other names at the local park. It also suits our backgrounds - Scottish Canadian and English/Scottish Australian. The middle name honours his grandfather and great-grandfather (by using their middle names).Now that we felt we did rather well naming our first, we're stuck trying to find an equally wonderful name for a second boy.We live in a large, culturally diverse urban centre, so the naming options out there are wild and almost nothing unusual is unheard of. We are not worried if the name seems slightly feminine, in fact I rather it than a macho boy name like Rock or Axel. We like names from the British/Scottish/Welsh extraction. They just suit our background. Other guiding principles, I prefer two-syllable names for boys and don't like a plethora of common nicknames.Our first decision was Errol which I love, but I got turned off it when I found some strange people on the internet that would have our son's first and last name. ARGH GOOGLE.All of our other choices are mostly E names:Emery/Emory - wondering if it skews too female these days, I prefer the 'o' spelling but I think the college is pronounced Em-OR-yEmrys/Emry - I like Emrys but the double 's' sound of the first and last names seems a bit lispy to me. Also the pronunciation of Emry does sound awfully like our first son's middle name. We wonder if people will just think we're mispronouncing Henry, which is a common name in our neighbourhood.other names I've liked:AudenGideonRufusMy husband isn't on board with any of these especially, but does not mind Rufus. It has the same double-s sound with our last name.I'm stuck for any other suggestions.Hope you can help!
The first name that came to mind was Omri: similar to Emory and Emry, but not currently used for girls. (In the United States, Emory/Emery/Emry are all used more often for girls than for boys.) Omri is the name of the little boy in the book The Indian in the Cupboard, one of my favorite books from childhood. It's almost unused (only 26 baby boys were given the name in the U.S. in 2011), but not too difficult to say or spell. I spent a little time online looking up the pronunciation: most sources say it's AWM-ree. One or two gave an alternate pronunciation of a long O sound and an emphasis on the second syllable: ohm-REE. My family said it AHM-ree: the O sound of Oliver.
The second name that came to mind was Arlo: similar to Errol, but perhaps without any shady associations.
The third name that came to mind was Ruben: similar to Rufus, but without the S-ending issue.
I wonder if you'd like Earl or Karl or Darrell or Merrill instead of Errol?
Or Claude or Alton or Alden or Odin instead of Auden?
A few more possibilities:
Russell (maybe too much L and S with the surname)
Name update! Sarah writes:
Thought I would update you on the name of our second son, born a few days ago.
We went back and forth on a few names before the birth, with Errol back in the mix along with a few of your suggestions, but THE name never emerged. When he was born, my husband felt strongly immediately he was a little Rufus (I love the nn Roo) so we set about finding a middle to break up the double-s sounding ends.
We settled on my father's name Wyndham, and together we think the name sounds lovely, as well as being a suitable companion name for his besotted brother Corin.
Thank you so much for your help and that of your readers!


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Bill Maher on California Tax Rate: Liberals, You May Actually Lose Me!by Free Britney at .
Even Bill Maher is feeling the sting of California's new income tax rates.
"Liberals," he said on a recent broadcast, "you could actually lose me."
He made the comments during a panel discussion of U.S. budget policy that included MSNBC's Rachel Maddow, who blasted Rep. Paul Ryan's proposal.
"The Ryan budget is a document that says the big problems in American right now are that rich people do not have enough money," said Maddow.
Maher responded, somewhat uncharacteristically: "You know what? Rich people - I'm sure you'd agree with this - do pay the freight in this country."
Maher cited statistics that California millionaires pay nearly 40 percent income tax to the U.S. government, plus another 13 percent to the state.
"I just want to say liberals ... you could actually lose me. It's outrageous what we're paying, over 50 percent," the left-leaning personality lamented.
"I'm willing to pay my share, but yeah, it's ridiculous."
Between national, state and local taxes, top California earners lose 55-60 percent of their income off the top. Of course, 60 percent of a million is still a ton.
What do you think? Fair or unfair?
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I'm in escrow to sell my business right now and guess what I'm doing - leaving California before we close, so I don't have to give 13%+ of the sale price to this wonderful state. CA can Kiss My A if they think I'm going to hand over that much money to them! And guess where the new parent company is sending our 100+ jobs after 18 months - that's right, the Philippines and India. courtesy of California Liberals like Bill M. At least he's waking up - the rest of them could give an F about ordinary people. All they care about is demonizing job creating capitalists like my partners and I. Bah bye CA
The US budget is $65,000 per family. So anyone paying less than $65,000 receives a subsidy from those who pay more. In essence I am on welfare.
Shrink the government so that it is affordable by and answerable to the average family.
Since we no longer feel the pain we will continue to ask for more free to us benefits. Healthcare, housing, food, education, aren't they all basic rights?
Instead make these things payable by us as charitable deductions 100% income deductible. Then all liberals can pay for what ever they think is "right" the religious can support their churches, communities can form special charities to pay for healthcare needs, educational opportunities, and the government can shrink welfare spending by the amounts citizens choose to give to their causes.
Sounds like FREEDOM!
I'm lovin' it. Obama used Maher and other fools like him for all he could get. Guess he doesn't need them anymore. lol When Maher moves out of California and leaves it to losers like Pelosi, Boxer and Feinstein, he can tell them not to worry, that Obama's 'sweetie' buddy, Georgie Clooney, wierdos like Pitt & Jolie, Cher, Michael Moore, Matt Damon and the rest of the Hollywierd fruits and nuts will pick up Maher's share of the tax load.
Also, here's a tip for Bill Maher....the GOP doesn't want you or need you. Maybe Ann Coulter will still want you. She's desperate!
55-60% to the government? Think again. Let's see: 39% fed income tax; 13.3% state income tax; 10% state sales tax. That's 62%, and they still have property taxes to pay, which brings the total tax burden close to 70%! They get to keep 30 cents of each dollar they earn. And that's not a fair share? I agree: that's not a fair share. That is an unfair share. That, dear reader, is socialism in action. And the state of California is not only broke, but is borrowing $40M per DAY to pay for unemployment. You want to see what the U.S. will look like in four years? Look at California today. And weep.


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Cavalli Beach House Retreat - Northland
$495 for Two Nights for Two People in a Luxury Waterfront Room at Cavalli Beach House Retreat Northland incl. Full Breakfasts (value $1,700)
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- Come and enjoy the absolute beachfront luxurious accommodation, surrounded by outstanding natural beauty.
- Grab a two-night Far North escape for two staying at Cavalli Beach House Retreat for just $495 - 40-minutes north of Kerikeri.
- Relax in a sensational waterfront room and enjoy the hearty cooked breakfasts.
- Love the isloation, which still lends itself to plenty of fun activities- kayaking, fishing, diving, or exploring the nearby Department of Conservation Mahinepua Reserve track opposite Cavalli Beach House
- Take a day trip to one of the many great destinations not too far away. There are five golf courses with 70 minutes including the world-famous Kauri Cliffs Golf Course only 15-minutes away - end your day with a relaxing soak in the secluded hillside jacuzzi.
Welcome to the Cavalli Beach House Retreat, your own exclusive and private water front luxury lodge, inviting you to enjoy the open air and ocean wilderness. Situated on the iconic Far North coast at Mahinepua, the retreat is a comfortable four hour drive north of Auckland or a 40-minute drive from Kerikeri, with the option of five flights a day from Auckland to Kerikeri/Bay of Islands airport (where rental cars are available with advance booking).
The architecturally designed lodge fits beautifully into the fully landscaped surroundings on an absolute beachfront site, which takes advantage of the stunning views of the private Rapaki Bay, the Mahinepua Scenic Reserve peninsula and the Cavalli Islands beyond. The whole property is abundant with native bird life.
Part of the joy of staying at Cavalli Beach House is the isolation, however, there are still plenty of wonderful activities and sights not too far away. Swim, kayak, snorkel, charter a skippered yacht, or take a fishing/sightseeing launch trip from the wonderful Whangaroa Harbour. The bustling Bay of Islands with its many attractions is also only an hour away.
You'll be well prepared for a day on the go with a generous breakfast that includes freshly squeezed orange juice, fresh fruits, Greek yoghurt and muesli followed by a cooked farmhouse breakfast. Great dinners are available with advance booking and at an additional cost. A visit to Cavalli Beach House Retreat lets you do as much, or as little as you like.
Past Grab One guests have loved their time at Cavalli Beach House Retreat - just two of the many accolades:
Thank you for your wonderful hospitality! You truly have an awesome lodge and thank you for putting on the great weather for us! We all thoroughly enjoyed ourselves ! - Christine, Auckland
Hi Carrie and Richard,
Thanks for a wonderful couple of days – amazing how a couple of days of relaxation and a bit of pampering made it feel like like we had been away for a week!!. Thanks for your A1 treatment. Certainly would love to come back one day! - Denise, Dargaville
Cavalli Beach House Retreat - Northland
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Bookings Essential. Subject to availability. Coupons can be combined to lengthen stay but must be used consecutively. Refund available from GrabOne within 48 hours of purchase. No cash back. Not to be used with any other offer. Max 2 people per room.
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201 Julia St, New Orleans, LA | Directions 7013029.944338 -90.064702
Neighborhoods: Central Business District, French Quarter - CBD
wonderful! – my boyfriend had already eaten here and suggested it to me while on the trip. the restaurant was refreshing compared to the the humid 90 degree weather, and the food was awesome.
we ordered the seafood gumbo, boudin link (good but small for the price), and the seafood platter (a huge amount of shrimp, oysters, crawfish, stuffed crab, jambalaya and french fries), all of which were delicious.
highly recommended!
Best Gumbo – I'm a Cajun, born and raised (but relocated), and I recently had the opportunity to dine at Mulate's in New Orleans. The food was outstanding... reminded me of my grandma's. The service was great, and the music even better. Definitely a great family alternative while in New Orleans. My kids loved it!
Average food, and prices a little on the high end. – As a born and raised south Louisiana boy, I have to admit this is not what I expected fom a local Cajun style resturant. The food was average and the prices a bit high. But then again, maybe I expect too much as my entire family is "Cajun" and Cajun food is what I was raised on. The place and the ambiance is nice and the service pretty good. If you are looking for a taste of Cajun cuisine, it's overall not a bad place to try.
Great cajun food – While in NO for a business convention a group of us went to this restaurant for lunch because it was close to the convention center. It was delicious! I had the fried crab platter and I have to say it is some of the best crab I have ever eaten in my life. This is the real deal when it comes to cajun food. The service was a little slow, but the place was really packed so we didn't mind waiting too much. I wish we could have returned for a 2nd meal while visiting but just couldn't make it happen. If I ever again return to New Orleans I would absolutely again go to this restaurant and would recommend it highly.
Good Music, average food – The music last night was Lee Benoit, he and his family were great, he's a great singer, we bought their CD. The food was OK, my wife and son ordered the shrimp/crab pasta, pasta and sauce tasted good.
Daughter had fried shrimo, kinda heavey tasting, didn't taste very fresh, fried alright but not a good flavor.
I got the Catfish Mulates, Catfish topped with Crawfish Etoufee. Crawfish in the etoufee were old tasting and gray looking, Jambalaya was OK. Ordered the catfish blackened and it was breaded instead.
Desserts were very good and good coffee. Dinner for 4 $100.00, Great atmosphere there that night, dancing, etc. Maybe caught it on a bad night.
Great Cajun food - and most certainly for locals! – I've been going to Mulate's with my family since I was a child and have always loved it. Sure, it appeals to tourists in some respects -it's located across from the Riverwalk, one of the most popular tourist spots. But I think they have never let their food lose quality just because they're coming in. Affordable food that satisfies any craving for somethin' Cajun.
It is COMPLETELY TOURISTY. You rarely will see a local here. The food is below mediocre and overpriced. Suggestion: go to a local restaurant (K-Paul's, Bon Temps, Domilise's Mandina's) then head out to Decatur/Charters/Frenchman, etc and go to one of the many music spots.
THE ONLY NAME IN CAJUN FOOD! – As a woman of Spanish/ Cajun heritage I asked my grandfather, a New Orleans resident where I could go to zydeco he promptly replied "well of course, Mulates!". I immediately told relatives of the place and they fell in love with it. It feels like an old dancehall spread out, and has a stage at the back. Zydeco bands come and play nightly. The crab au gratin is good (but pricey), the red beans and rice and the absolute best on this planet, the french bread is good also. There might be other copycats, especially here in Texas, but Mulate's can trample them.
Touristy version of the bayou original serves Cajun vibes and victuals. – The Scene
The cavernous dancehall dining room is accented with a stage, dance floor and bayou murals. The massive papier-mache accordion above the bar clues you in that this place is all about Cajun flavor on a New Orleans scale. Out-of-towners from the convention center across the street and hotels around the corner eat and dance side by side with locals who come for Cajun food and fun.
The Food
Catfish Mulate's is all you need to know--etouffee, jambalaya and corn macque choux all on one plate. Other greats include alligator (get it fried, grilled or blackened), red beans and rice, and gumbo galore. Mulate's Amber is a house-made draft that drinks like a tasty red ale. Another appropriate brew is Dixie's Blackened Voodoo.
mulate's – Real Cajun food! Not pseudo cajun for tourists. What makes people think that if you add plenty of spices and tabasco sauce food becomes Cajun?
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To get you ready for Week 2 of the college football season, Aaron Torres has been breaking down all of college football's top teams, coaches, and players. To see his entire top 25, as well as the remainder of this preview, click here, or visit him at www.aarontorres-sports.com/)
One week of college football is in the books. And what a very interesting week it was.
Think about it, the two biggest stories of the week included a backup defensive end from Boise State, and a right AC joint. What we couldn't get Arkansas State's defensive backs coach a little airtime as well? Welcome to the 2009 college football season my friends.
With the first set of games behind us, let's get to Week 2. Week 2 is interesting because of a disturbing, yet fascinating trend: There isn't a home favorite that I'm totally comfortable backing. Seriously look up and down the lines, I'm not comfortable with any of them. Florida is playing the top team in the Sun Belt. Virginia Tech hosts a pesky Marshall squad, Alabama an improved FIU team.
It's going to be a tough week for the home teams, and a tough week for us to handicap the games. Either way, let's get to the picks!
Syracuse (+28 ??) over PENN STATE: Saturday, 12:00 p.m.
If you're picking Penn State to cover in this game, you're basically admitting to me that you didn't watch Syracuse's opener against Minnesota. Go ahead admit it. Admit it!
Because if you did watch, you know two things: That Greg Paulus actually looked like a real quarterback against Minnesota, and that Syracuse's defense is infinity times better than they were last year.
As someone in Big East country who was subjected to entirely too many of Syracuse's games during the Greg Robinson era, this looked like a totally, completely different team than the one that took the field these last few years. If it wasn't for the goofy uniforms and the Carrier Dome's shag carpet, I honestly wouldn't have believed it was Syracuse on the field.
Even Jo Pa admitted in his weekly presser on Tuesday that Syracuse looks much better on film now than they did a year ago.
And if Joe Pa says it, it must be true. Sure he's senile, but the guy is like 165-years-old. Have you ever been around someone his age? They say whatever's on their mind at all times. There's no holding back.
A few weeks ago I took my 93-year-old grandmother out to get ice cream and she openly questioned whether some of the people in line should actually be ordering ice cream as opposed to going on a diet. And she said it in a loud old person's voice that everyone in the place could hear.
My point? Old people don't waste anyone's time lying, they don't have much of it left. So if Joe Pa says Syracuse is better, believe him.
Notre Dame (-3) over MICHIGAN: Saturday, 3:30 p.m.
Here's the thing, I think Rich Rodriguez is a better coach than Charlie Weis, and the better coach usually wins close games. Don't let last year fool you, I saw Rodriguez a ton at West Virginia, and I promise you folks, the man is the real deal.
For example, say this game is tied in the fourth quarter, and ABC decides to show a split screen of these two guys on the sidelines. Who would you be more confident in, Rodriguez with his Oakley sunglasses hugging his face, calmly whispering into Tate Forcier's ear? Or Charlie Weis and his oversized, color coordinated play sheet, with dried saliva crusted to the corners of his mouth? I thought so.
But with that, here's why I'm taking the Irish: If we learned one thing from last weekend, it's that the team with the better offensive line won every big game, with the possible exception of Florida State-Miami. Think about it, BYU over Oklahoma, Boise State over Oregon, Alabama over Virginia Tech. Even Oklahoma State was able to get a good push against Georgia. And in this one, Notre Dame has a huge (no pun intended) advantage along the offensive line.
While I'm still not sold on Jimmy Clausen (didn't he still seem to throw a lot of balls into triple coverage last week?), Charlie Weis' coaching internship should continue with another victory.
(To read the rest of Aaron's Week 2 preview, click here)
Houston (+15) over OKLAHOMA STATE: Saturday, 3:30 p.m.
Three thoughts and three thoughts only on this game:
1. There is no way Oklahoma State won't have at least a minor let down after the Georgia game last week. It's inevitable.
2. Dating back to last year, Houston has scored 40 or more points in seven of their last nine games. Conference USA or not, that is a lot of end zone celebrations my friends. Did I mention they put up 37 in Stillwater last year?
3. When did every coach, announcer and analyst decide that we will never again refer to a quarterback as a quarterback, but instead someone who plays "The Quarterback Position." I'm not quite sure who came up with this term (Yes I'm looking your way Ron Jaworski) but, why can't we just say Case Keenum and Zac Robinson are good quarterbacks, rather than saying, "They both sure know how to play the quarterback position."
We don't say someone sure knows how to play the "defensive end position," or the "punt returner position." We don't use the term in any other walk of life. Nobody ever says, man, he sure is great at the "CEO position." No the guy is a good CEO. Alright, I'm done rambling now.
Vanderbilt (+14 ??) over LSU: Saturday, 7:00 p.m.
The only way Vanderbilt has a chance in this game is to keep the ball on the ground, keep the clock and chains moving, and slowly try to suck the life out of Tiger Stadium. LSU wins, Vanderbilt covers. The end.
As for LSU, can you think of team that is going to improve more over the course of the season than these guys? I'm scared, seriously scared, to think about how good they'll good be in a few months.
The Tigers have young quarterback and younger defense, both of which are only going to get better with more game reps. Jordan Jefferson, just turned 19-years-old a few weeks ago. 19-years-old! Think back to what you were doing at that age. My guess is it involved phrases like, "Keg stand," and "I swear officer, I was just holding it for a friend," and probably didn't include "starting SEC quarterback."
I still think the Tigers schedule might be a bit too tough to win the SEC West this year, but they could potentially be the No. 1 team in the country coming into 2010. Not to get too far ahead of ourselves.
South Carolina (+7) over GEORGIA: Saturday, 7:00 p.m.
So how many road teams am I going to pick to cover this week? 50? 100?
But in regards to this one, was it just me, or did anyone else notice Joe Cox didn't seem as poised as you'd expect for a 5th year senior last Saturday? He took some bad sacks in key situations, and forced too many throws. I know he had the flu, but come on guy, you waited four years for this game, and all you could muster up was a first possession touchdown drive? Against Oklahoma State's defense? Really?
As for South Carolina, I want to be the first one to throw it out there: We are all going to enjoy the Stephon Gilmore experience in Columbia. I checked the stats, and apparently he didn't register a tackle in the entire game against NC State. But I seem to remember him being around the ball on every single big, fourth quarter play last Thursday. Maybe I'm getting old, but I swear I remember that happening.
More importantly, the guy is the first player I've seen during the Steve Spurrier era that plays with that Eric Berry/Tim Tebow/Rolando McClain confidence/swagger/borderline cockiness that says, "Not only do I belong on the field with these guys, but I'm better than the guy lining up across from me. Throw the ball my way. Go ahead I dare you." Trust me, the kid is going to be a star.
Also of note, the last two times the Gamecocks have gone between the Hedges? A 17-15 loss in 2005 and a 16-12 win in 2007.
(Want the rest of Aaron's picks, including his thoughts on USC-Ohio State and UCLA-Tennessee? Click here or visit him at www.aarontorres-sports.com/)