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- BRS Bulk Calcium Chloride Aquarium Supplement
Salifert Calcium Aquarium Test Kit$23.99
BRS 2 Part Doser – 1.1 mL per minute$79.99 As low as: $75.99
Hanna Checker Calcium Colorimeter$49.99
Red Sea Calcium Pro Test Kit$29.99
Red Sea Reef Foundation Pro Multi Test kit (Ca,Alk,Mg)$49.99
Bubble Magus Dosing Pump
Starting at: $274.99
Bubble Magus Liquid Storage Container
Starting at: $35.99
Bettix Bottle with Dispensing Cup
Starting at: $4.99
Great Product By John on 4/1/14John would recommend this product to a friendGreat Product. Mixes up fast and VERY clear.
good product but By Dustin on 12/11/13Dustin would recommend this product to a friendworks great but I have to use a lot in my tank to keep the cal up
Great product By Steve on 11/26/13Steve would recommend this product to a friendHave been using this product for around two years in my mixed 280 as part of my two part dosing. Easy to use, economical, and great results. I would recommend this product
Nice product By Maz on 11/23/13Maz would recommend this product to a friendI've been using this 2 part for 3 years or so. I started with manual dosing and have since moved to the 1.1ml dosing pumps and my parameters stay rock solid.
Awesome Product By falconut on 9/5/13falconut would recommend this product to a friendI've been using this stuff for years with great results. Mixes clear within a minute. Excellent product BRS.
Great Product By David on 8/18/13David would recommend this product to a friendJust started using BRS 2 part and kalk. Just raised the Cal to where I wanted it. Very easy to use and understand.
Calcium By Dabiggooch on 8/4/13Dabiggooch would recommend this product to a friendAwesome product!
The Best The Best The Best By BigEZ on 7/22/13BigEZ would recommend this product to a friendGreat product, it's not horribly expensive and it dissolved way quicker than I was expecting. Using the calculator on the site made it super simple to adjust my calcium levels.
Works well By Chris on 7/19/13Chris would recommend this product to a friendI received this yesterday and followed the very clear mixing instructions on the package although I reduced it to just 1 cup of water and modified the CaCl to match. Before I used it I tested with a Salifert kit and my Ca was reading 400. Afterwards I tested again and it was reading 450. It's exactly the amount I had mixed for.
What a great product.
Great Product By Corey on 6/24/13Corey would recommend this product to a friendI have been usuing this product for a year with no problems. Once its dial in on the dose I just refill my dosing containers when they are empty. I have great coral growth on all my SPS and SPS corals.
buy in bulk By maria on 6/13/13maria would recommend this product to a friendSaves time and money !
Great product By Bill on 6/7/13Bill would recommend this product to a friendThis is a great, cost efficient two part dosing solution. I have used it in my 200g system for over two years with success.
Determining the Quality of your Reef SupplementsThis video is a demonstration of a few aquarium su ...
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Calcium, Alkalinity & Trace Elements: EP 1 Maintaining Calcium & AlkalinityMaintaining calcium and alkalinity in your saltwat ...
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Ask a Question About 'BRS Bulk Calcium Chloride Aquarium Supplement '
Previously Asked Questions
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- Test current calcium level
- Use our Reef Calculator
- Input required information and select Recipe 1 Calcium Solution
- Follow calculator's guidelines when adding to tank
- 1 Standard 8 oz. dry measuring cup
- 1 Empty 1 gallon jug
- 1 Funnel
- 1 RO/DI or distilled water
Add 2½ dry measuring cups of calcium chloride to a gallon jug and mix with RO/DI or distilled water to create a full gallon of solution.
Recommended Starting Points for Daily Dosing
Predominantly LPS and soft corals .1 mL per gallon A few hard SPS corals and clams .2 mL per gallon Numerous full sizes SPS colonies and clams .3 mL per gallon
BulkReefSupply.com recommends maintaining calcium levels at 420ppm.
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John Doe
John Doe enlists help to control the visions that begin to assail him and uses that help to track down the Phoenix organization and their captives. Doe rescues Teresa, the girl he's been after, and the face of Stocking Cap is revealed.
Kate Middleton, Prince William, Wiggling Prince George Arrive in Sydney, Australia: Adorable Pictures!
Kate Middleton, Prince William and their adorable baby boy, Prince George, arrived in Sydney on Wednesday, April 16 -- see the cute photosUs Weekly
Mila Kunis, Ashton Kutcher Having a Girl! Pregnant Star's Baby Gender Revealed
Pregnant Mila Kunis is having a baby girl, sources confirm exclusively to Us Weekly; her fiance Ashton Kutcher "got plenty of practice" with ex-wife Demi Moore's three daughters, one pal saysUs Weekly
Staying Together: Catherine Zeta-Jones and Michael Douglas Make First Public Appearance Together Since Break
Catherine Zeta-Jones and Michael Douglas have made their reconciliation red carpet official.Yahoo Celebrity
Here are all the passwords you need to change right now because of Heartbleed
By now, we all know what a huge deal Heartbleed is. The massive vulnerability in OpenSSL protocol impacted 66% of all sites on the Internet at the time of its discovery, and now companies are scrambling to fix the issue. Most big companies seem to have done a pretty good job of acting quickly, but…BGR News
DEAR ABBY: I have been in a long-distance relationship with "Victor" for several years. Recently I began to suspect he was cheating. What raised my suspicion was that I suddenly couldn't reach him on the weekends. Usually we would Skype -- Sunday night for me, Monday morning for him. Last February…Dear Abby
Candace Cameron Bure Shows Some Skin in Sexy Seashell Bra on Dancing With the Stars' Disney Night
Candace Cameron Bure loosened her modest costuming rule to wear a sexy seashell bra as Ariel from The Little Mermaid on Dancing With the Stars' Disney night -- see a pic, and find out how her kids reacted to the outfit!Us Weekly
All-new 2015 Toyota Camry becomes an edgier appliance
Toyota finds itself in a tricky situation. Those that enjoy cars as more than a simple means of transportation think of the Camry as a bland spongecake gone stale. And yet it's been the best-selling vehicle in the entire industry for the past 12 years, with a car rolling off the production line…Motoramic
Brad Keselowski: Going broke and losing everything
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Now There's Video Of Paulina Gretzky's Controversial Shoot
Golf Digest annoyed some LPGA players by putting a scantily clad Paulina Gretzky on the cover of its May fitness issue. Now there's behind-the-scenes video of the photo shoot that started all the fuss. In the clip, Gretzky, the daughter of hockey great Wayne Gretzky and actress Janet Jones, goes…Huffington Post
First Round Predictions
The Rotoworld Hockey Staff has made its predictions for the first round of the playoffs and some may surprise you.Rotoworld
Possible Mars Mission 'Showstopper': Vision Risks for Astronauts
Mars may possess a stark and austere beauty, but a manned Red Planet mission will likely not be easy on the eyes. Recently, scientists have begun realizing that spaceflight can cause serious and perhaps permanent vision problems in astronauts. NASA researchers are working hard to understand the…SPACE.com
Bicyclist Michael Bowman Beaten In Attack Caught On Helmet Cam In Baltimore
A bicyclist was knocked off his bike and beaten in Baltimore over the weekend, and the start of the attack was caught on his helmet-mounted camera. Michael Bowman said he was riding on Guilford Avenue Saturday night when the group of strangers surrounded him and he couldn't pedal away. "It's a long…Huffington Post
Flight Attendant's Hilarious Safety Instruction Video Goes Viral
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Seahawks running back Christine Michael takes girl with autism to her prom
A couple months after being part of a Seahawks team that won a Super Bowl, Christine Michael couldn't have looked any happier dancing at a high school prom. His date, Taylor Kirkwood, looked even happier. Kirkwood, from Houston, is autistic and suffered from scoliosis until surgery a couple years…Shutdown Corner
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The son of a Calgary police officer was charged in the fatal stabbing of five people at a house party that the law enforcement officials called the worst mass slaying in the western Canadian city's history. Matthew Douglas de Grood, a recent graduate of the University of Calgary, picked up a large…Yahoo News
Colorado Pot Shops Raided By The Feds May Be Shut For Good
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Male Police Officer Dresses As Amish Woman To Catch Alleged Child Predator [PHOTO]
Police officer Chad Adams dressed as an Amish woman for nearly two months earlier this year, in an attempt to catch a man who Amish families in Western Pennsylvania said was exposing himself to their children. "I was the butt of jokes from all around, but everyone thought it was a good operation,"…Huffington Post
Obama Promotes a Society of Helpless Victims
Eric Holder stirred up a hornet's nest the other day, whining to a mostly black crowd about the ill treatment he received from a Congressional Committee. Holder seemed to imply that he and President Obama have come in for rough treatment because they are black. This is, after all, Eric Holder, the…The Fiscal Times
Damian Lillard offends Chris Webber and Karl Malone in new Foot Locker ad (Video)
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Andi Dorfman's Bachelorette Promo Poster Disses Juan Pablo Galavis: See It Now!
The first poster for Andi Dorfman's upcoming season of The Bachelorette takes a not-so-subtle dig at former Bachelor Juan Pablo Galavis -- see it now!Us Weekly

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Shoeless Joe Golden Era Series 1925 Baseball Glove
Golden Era Gloves
A recreated series of reproduction Gloves from the first half century of Baseball. Each Glove is hand cut and sewn using the original patterns and components of that particular time period. Any generation of ballplayer can play today with the same glove they used to experience the great game of Baseball from the years past. Our Craftsmen have created a timeless glove for your game today.
Glove Specifications
Pattern: 1925 Fielder's Glove.
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The Buzz: What's the dirt?
With a break in the weather, 2014 construction projects got underway. Here are three that have started in the Fox Cities.
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With a break in the weather, 2014 construction projects got underway. Here are three that have started in the Fox Cities.
Every Monday, Post-Crescent Media talks to business leaders in its Monday conversation feature. Today, Pam Seidl, executive director of the Fox Cities Convention & Visitors Bureau, talks about the upcoming tourism season in east-central Wisconsin.
Stocks were mixed Monday at the start of another major week for company earnings. The Standard & Poor's 500 index is coming off its best week since July as first-quarter corporate earnings begin to come in.
A woman called in from Appleton's southside looking for bagels. And not just any old bagels. She wanted them freshly made, like the ones she used to buy at SueAnn's Bagels on Calumet Street.
They're gluten-free, sugar-free and carb-free cheese crisps that are low in sodium and high in protein.
Name: Ja Ia Thao
Associated Banc-Corp, parent company of Associated Bank, reported net income of $44 million, or 27 cents per share, for the quarter ended March 31.
The Small Business Development Center at the University of Wisconsin-Green Bay will present three free webinars on enrichment opportunities.
Grant Pauly could have had a stable career at his family's Kiel-based concrete company.
When I was little, my folks took us to see 'Pete's Dragon.' The Disney flick was about a boy and his dragon, Elliott, who ran away from their abusive foster family.
The increasingly dynamic nature of the economy means that while workers themselves may be living longer, companies are not.
Since my oldest son is in college now, I plan to have 'the talk' with him when he's home from school this weekend for the Easter holiday. Yes, we're going to talk about his credit score and how it can either be his best friend or his worst enemy.
How much does the weather influence your mood? If the sky is heavy with foreboding grey clouds, and torrential rain is about to be unleashed, what happens to your attitude? Are you anxious and preoccupied with the storm?
Just Act Natural celebrates the earth every day, but this week the shop gets a welcome boost in sales when everyone else jumps in.
Inspiring Interiors opened Monday at 132 N. Main St. in Kimberly.
Of all the ways used to describe Infiniti's halo sedan, the 2014 Q70 (formally the M Sedan), it can all be summed up in one word: inspired.
A new Manitowoc movie theater with a screen that will measure three stories tall and feature stadium-style seating will open in early summer.
The south-central Wisconsin property where more than 23,000 people once toiled in making bullets, bombs and rockets during World War II and the Korean and Vietnam wars will be open to recreational visitors for the first time since the 1940s.
Schwag will leave its Grand Chute location at the end of April and reopen May 7 in Appleton.
TNT Fitness Results will open Monday at 880 S. Oneida St. in Menasha. Its a new fitness business taking the gym location that has been vacant since Underground Functional Fitness closed in Aug. 2012. One of the partners in the new business, Brent Miller, had worked as an instructor at the prior gym, but the two businesses are not affiliated.
The Women's Fund for the Fox Valley Region and Mid-Day Women's Alliance will jointly host a free workshop Thursday on equal pay for women.
The Port Green Bay is one of six ports selected for an annual award for increases in international cargo during the 2013 shipping season.
Prospera Credit Union will host a free workshop Tuesday and Thursday on how to create income that lasts for 30 years or more.
SCA will mark Earth Day in the Fox Cities with events that include electronics recycling for employees at its three facilities in Neenah and Menasha.
Baylake Corp., parent company of Baylake Bank, declared a quarterly dividend of 7 cents per share, payable June 2 to shareholders of record May 12.
Driving around the Fox Cities midsummer, it's easy to see that people take time, effort and pride in lawns and gardens. The simplest house might be surrounded by a riot of colorful flowers and lush vegetation.
City leaders want a new five-story apartment building in downtown Green Bay to stand out, not blend in.
This week's 'Throwback Thursday' story commemorates Cinderella, a name on three separate Town of Menasha buildings going back to 1925.
Wisconsin's unemployment is down to 5.9 percent, its lowest level since November 2008.
Gilly's Frozen Custard has closed its 1950s-style drive-in restaurant on Sheboygan's south side.
Nominations are sought for the sixth annual New North Workplace Excellence award.
With its broadest ever heavy-duty truck line-up ever, GMC unveiled the current Sierra heavy-duty pickup truck at the 2010 Chicago Auto Show.
The number of people seeking U.S. unemployment benefits last week rose 2,000 to a seasonally adjusted 304,000. Jobless claims continue to be near pre-recession levels despite the slight increase.
Major U.S. stock indexes drifted between gains and losses in morning trading Thursday amid a crop of disappointing corporate earnings. Google, IBM and insurers UnitedHealth and WellPoint were among the big market decliners.
First National Bank Fox Valley announced plans Wednesday to open a new branch on the north side of Appleton.
As Chevrolet's first V-8, rear-wheel-drive performance sedan since 1996, the new 2014 Chevrolet SS is designed to deliver performance on the street and on the track.
A local health care consortium will play a greater role in the training and development of future physicians, starting next year.
The days of delivering coffee by horse and carriage may seem distant but the core of the coffee-making process remains the same, says Jay Torke, chief operating officer of Torke Coffee Roasting Co.
U.S home construction rose moderately in March as builders resumed work at the end of a frigid winter. But applications for building permits slid, clouding the outlook for future construction.
Reader question: Do you know if We Care Meals will be serving a free Easter dinner this year?
Contract electronics manufacturer Plexus Corp. on Wednesday reported $18.5 million, or 53 cents per share, in net income for the second quarter, compared with $17.7 million in the first quarter.
Nicolet Bankshares Inc. reported $2.2 million, or 50 cents per share, in net income for the first quarter, compared to $1 million in the fourth quarter.
Stocks are moving higher for a third day in a row after more U.S. companies report solid earnings and on encouraging news about China's economy.
Reader question: Touchmark is expanding on West Prospect Avenue. An old barn was demolished presumably to prepare for this expansion.
A long, miserable winter has taken its toll on Sheboygan's Harbor Centre Marina, where officials say shifting ice crushed docks and caused an estimated $350,000 in damage, by far the worst in the marina's 20-year history.
School Specialty Inc.
The state's moratorium on disconnecting utility customers who are behind on their bills is ending.
Hang onto your place cards and centerpieces.
BrightStar Care of Appleton, Fox Cities and Waupaca area is seeking nominations for the second annual BrightStar Care Nurse of the Year Award.
A workshop will be held April 30 in Madison to help local food producers grow their sales outlets this season.
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April – May 2013
Registration and Youth Waivers will be taken from 6-7:30pm
The Meeting begins at 7 pm.
Come see all the New and Exciting things we have in store for the 2013 Race Season.
Quarter Midget Registration in the Convention Center from 6-7pm.
Number Registration is $10
Gates Open at 10:00 am, Ticket booth closes at 5 pm.
Tech from 10 am – 7 pm
On Track Practice from 1 pm – 7 pm
Drivers $25, Crew $10, Spectators $5
Gates open at 5 pm. Practice Starts after registration confirmation.
Driver $15, Crew $10, Spectator $5
Gates open from Noon to 6 pm.
On track at 2 pm, running until Dusk.
Drivers $25, Crew $10, Spectators $5
The 2013 Super Oval race season officially begins tonight!
Racing: Maverik Modifieds, Winged Sprint Cars, Comcast Super Stocks, Mini Cups and Trains
Adults $15, Youth (5-12) $5
Reserved Seating $20
Purchase your tickets online and receive a FREE POPCORN with every ticket.
Gates open at 4 pm, Green Flag at 6:15 pm
Our Season Opener Featuring


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Influence Of Silanol Content, Humidity And Temperature On Efficacy Of A Silica Based Carrier
Recently, silica based carriers have been widely used for the adsorption of oily and lipid based formulations. Using silica as adsorbent, liquid self emulsifying drug delivery systems could be formulated in tablet or capsule oral dosage form. For this application, an ideal carrier is one which possesses high adsorption capacity and immediate desorption or release at desired site. Three different types of carriers like Granulated fumed silica (GFS) Syloid® XDP-Mesoporous silica gel (MSG) and Magnesium aluminum silicate (MAS) were selected for this study. By Yogesh Choudhari, Upendra Reddy, and Fred Monsuur, Grace
Using Spray Drying For Flu Vaccines: What Challenges Do We Need To Overcome?
When discussing the challenges of manufacturing flu vaccines, the conversation often shifts toward how manufacturers can meet the global demand each year. Currently there are some very innovative technologies aimed at addressing the challenge of manufacturing a larger supply of flu vaccines in a shorter amount of time, such as Novartis' use of cell culture and Medicago and Fraunhofer's use of tobacco plants. However, being able to deliver enough of a vaccine is only half the battle. It also needs to be delivered to its final destination within the appropriate temperature range. "It's a huge misnomer for people who believe these technologies will unconstraint flu," says Jim Robinson, VP of global technical operations, biological, and sterile products at Merck, who was involved in the manufacturing of billions of doses of flu vaccine prior to joining Merck. "The product still needs to get into a usable form and be delivered safely to the patient."
BDP Week Highlights The Importance Of Communication In BioPharma
At this year's Biopharmaceutical Development and Production (BDP) Week, March 24-27 at the Hilton Bayfront Hotel, I attended several sessions that focused on how to strengthen the relationship between partners in the pharmaceutical industry. One overwhelming theme in each presentation was the importance of communicating effectively and clearly with everyone involved in a project.
Time Is Money, So Spend It Wisely
In a traditional office environment, hours upon hours are often spent collaborating with other people to come up with game-changing ideas. Even the time spent alone at your desk can be occupied with juggling multiple responsibilities and tasks. It's usually only during downtime at the end of the day, whether it's a quiet ride home in the car or lying in bed at night, that we allow ourselves time to relax and reflect. Tony and Oliver Stauffer, president and chief operating officer at Packaging Technology & Inspections, as well as father and son, believe it's during these moments to ourselves that we have the ability to come up with some of our best ideas.
The Changing Regulatory Landscape: How Drug Sponsors And CMOs Can Navigate It Together
The changing regulatory environment is shaping a new paradigm between drug sponsors and contract manufacturing organizations (CMOs). One key aspect is demonstrated quite nicely in a case study from February 2012 (read it here), when the FDA issued a warning letter to a contract manufacturing organization. The warning letter stated in part:
"In your response, you state that you have informed your clients on the importance of validating the methods, but they have chosen not to validate the methods. In addition, you state that you will inform them again in writing. Your response, however, is inadequate because you do not provide your firm's planned corrective actions for this CGMP violation. You are responsible for ensuring that the test methods used by your firm are validated." (Emphasis added)
Hygienic Processing: Elimination Of Dead Space Volume
Hygienic processing places high demands on the reliability and cleanability of production facilities. These requirements are especially high in separation processes like filtration and chromatography and are significant in ensuring purity of media by maintaining sterile process conditions.
Online Glucose | Lactate measurement In Batch And Fed-Batch CHO Cultivation
During the cultivation of animal cells the monitoring of nutrients and metabolites has an important role for the controlling strategy of the cell culture.
Process Optimization Made Easy: Design Of Experiments With A Multi-Bioreactor System
Design of experiments (DoE) is one of the most important techniques for systematic planning, execution and statistical evaluation of experiments.
Automated Cell Dispensing And Image-Based Spheroid Formation Tracking
Scientists using cell culture for drug discovery, toxicology, stem cell biology, and basic research realize the critical importance of 3-dimensional (3D) models. Data from cells cultured in a non-physiologic, monolayer format on plastic surfaces has long been suspected to differ from true in vivo physiology, and there is mounting evidence that this difference is slowing the pace of scientific discovery. By Brad Larson and Peter Banks, Applications Department, BioTek Instruments, Inc., and Nicky Slawny, 3D Biomatrix, Inc.
Challenges In Biosimilar Monoclonal Antibody Cell Culture Process Development — Media Optimization Is A Key To Success
Biosimilar, a term synonymous to "follow-on biologic" requires very stringent and high standards of comparability with the original biologic drug that is being replicated. Unlike conventional small molecules and chemical generics, "biogenerics" or biosimilars, especially monoclonal antibodies, have complex structure and function that are affected by slight changes in the manufacturing process.
Live Cell Imaging Of GPCR Dependent Second-Messenger Systems
A significant proportion of academic and drug discovery research is devoted towards the elucidation of second messenger signaling cascades resulting from interactions between G-protein coupled receptors (GPCR) and their ligands. By Paul Held Ph. D. and Peter Banks, Ph. D., BioTek Instruments, Inc. and Paul Tewson, Anne Marie Quinn and Thom Hughes, Montana Molecular
Cargo Companion Tracking Solution
The commercial air cargo industry's most comprehensive tracking solution provides location and temperature information for your time-critical, high value and temperature sensitive cargo.
Global Cold Chain Logistics As cold chain shipments excursions face increased scrutiny from regulators around the world, it is more important than ever before to get it right the first time.
ISPE Baseline® Pharmaceutical Engineering Guides Created in partnership with the US Food and Drug Administration (FDA), the ISPE Baseline® Pharmaceutical Engineering Guide Series offers practical solutions to the complex, dynamic challenges facing facility designers today. In addition to providing an understanding of products and processes, the Guides also offer an outline of architectural and utility systems needed to meet government requirements...
Temperature-Sensitive Shipments: RKN t2 Container
The Envirotainer RKN t2 container provides accurate and reliable protection for shipments of temperature-sensitive products.
Fluid Control Systems For Sterilizers And Washers
Infection protection is a rapidly growing industry where sterility and reliability are crucial.
Celldex Reports Positive Phase 1 Results For Tumor Vaccine
Celldex Therapeutics reported positive final data from the Phase I study of its tumor vaccine CDX-1401 in solid tumors.
- Wilson Therapeutics Gets $40M In Private Funding For WD Program
- U-M Researchers Use Silly Putty Ingredient To Study Stem Cells
- New Blood-based Assay May Help Predict Breast Cancer Recurrence
- Nanoparticles Zero In On Cancer With Triple Chemo Drugs
Temperature Monitoring Technology for Healthcare Shipments
Logistics expert Kevin O'Donnell, Senior Partner, Exelsius Cold Chain Management, presents the basics of temperature monitoring for healthcare shipments. From simple temperature indicators to more sophisticated electronic systems that include intervention protocols, you have more options than you may think. Kevin Etter, Product Manager, UPS Global Healthcare Logistics Strategy Group, explains why it's so important to know what's going on during high value shipments.
How To Assess Total Logistics Cost
Watch this new video to learn new ways to calculate total logistics costs. Susan Li of the Healthcare Strategy Group at UPS reveals the true costs of packaging and shipping.
Biobanking And The Future Of Translational Medicine: Dr Gyorgy Marko-Varga Interview 2 Of 3 Dr Gyorgy Marko-Varga highlights how biobanking will be critical to realize the promise of Translational Medicine and what challenges we need to overcome quality hurdles going forward.
We are a global market leading provider of an air cargo cold chain transportation concept to pharmaceutical companies and their logistics partners. We are unique and the benchmark for global air cargo cold chain management and logistics solutions.
ISPE, the International Society for Pharmaceutical Engineering, is the world's largest not-for-profit association serving its Members through leading scientific, technical and regulatory advancement throughout the pharmaceutical lifecycle.
DASGIP Information and Process Technology GmbH an Eppendorf company
Rapid technological advances in biotech and pharmaceutical industries have created increasing demands in research and development. DASGIP Parallel Bioreactor Systems for the cultivation of bacterial, phototrophic, animal and human cells at bench top scale support scientists and engineers to accomplish their projects quicker and more efficiently.
Welcome to BioResearch Online, the premier Internet source of useful and timely information for the worldwide bioresearch and life sciences industries. This site is designed to serve the needs of laboratory directors, laboratory managers, researchers, scientists, university faculty members, business executives, and other industry professionals. BioResearch Online provides daily news updates and in-depth feature stories about drug discovery, research and development advancements, university-industry collaborations, and regulatory issues.
On this site, industry professionals will find information about new products and technology, bioanalytics, bioreactors, biopurification, bioproduction products, bioprocess sensors, cell culture media, biopharm contract manufacturing, chromatography, lab informatics, lab automation, laboratory systems and equipment, molecular and cell biology, pipettors, assay instruments, genetic sequencing, immunochemicals, enzymes, hardware and software systems, and more.
Bioresearch Online is part of the Life Science Connect media group. The vision of Life Science Leader and Life Science Connect is to help facilitate connections and foster collaborations in pharmaceutical and medical device development to find ways to get more life-saving and life-improving therapies to market in an efficient manner. Connect, Collaborate, Contribute.
Please take a moment to join our community and discover the benefits of your free membership.
Building Accountability on Your Clinical TeamsApril 29, 2014
1pm-2:30pm EDT, Online Training
Root Cause Analysis & CAPA Identification: A Step-by-Step Guide for ManufacturersApril 30, 2014
1pm-2:30pm EDT, Online Training
Risk-Based Monitoring for Clinical Trial Sites – Keys to Successful ImplementationMay 1, 2014
1pm-2:30pm EDT, Online Training
Root Cause Analysis for Clinical Research ProfessionalsMay 5, 2014
1pm-3pm EDT, Online Training
Qualifying Your Trainers – What Do They Need For Your Training To Be Effective?May 8, 2014
1pm-2:30pm EDT, Online Training
H.R. 3204 Drug Quality And Security Act
After so many years of struggling with how to comply with the California ePedigree requirement, we now need to know how to comply with the new federal requirement, H.R. 3204. This webinar will review DQSA requirements and timelines.
PAT-Enabled Process Optimization & Control
PAT is a risk-based strategy for designing, analyzing and controlling manufacturing processes. The Critical Process Parameters (CPPs) are identified in line with the definition of the Critical Quality Attributes (CQAs) of intermediates or final products. PAT offers a number of tools for measuring and controlling these CPPs.
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Adoption of Membrane Chromatography in the Vaccine Industry
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Foreign Wake
I'm proud to announce that my debut LP entitled "Foreign Wake" is finally available. This album features a mix of Electronic, Instrumental Rock, and Dance music that comes together for a beautiful electronic sound. Great music to listen to while you're working out, driving or just chilling out at home.
Foreign Wake represents me revamping my entire style of production and starting over on a new musical journey, picking up bits and pieces along the way from instruments and genres new to me. That's also what the Cover art (by Keys n Bass) represents.
You can listen and purchase the album from anyone of the links below. Also you can listen to the album in full at LastFM.
Thanks for the support and I really hope you guys enjoy it.
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Super Bowl 47 is in the books. Now that we have crowned the Baltimore Ravens champions, we can also close the book on the single largest advertising day of 2013. As always, the advertisements were ... interesting. There were several winners, plenty of losers and even a few that still have us scratching our head. At an average cost of $3.8 million for 30 seconds, which companies made the most of their time and which would have been better off saving their money? Disagree with something on our list or think we made a glaring omission? Let us know in the comments. Five Best Ads from Super Bowl 47 By: David Rogers Overall, I thought the 2013 crop of commercials were not only pretty weak, but that they also had some of the most divisive commercials in recent memory. Very few commercials could be unanimously picked as either a winner or a loser. Over on Twitter, the @Awful_Ads feed would be filled with commentary both ridiculing and praising the same commercial. In no par...
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Sprigman received his B.A. with honors from the University of Pennsylvania in 1988. He attended the University of Chicago Law School, serving as a comment editor of the University of Chicago Law Review and graduating with honors in 1993. Following graduation, Sprigman clerked for Judge Stephen Reinhardt of the U.S. Court of Appeals for the Ninth Circuit, and for Justice Lourens H. W. Ackermann of the Constitutional Court of South Africa. Sprigman also taught at the law school of the University of the Witwatersrand, in Johannesburg, South Africa.
From 1999 to 2001, Sprigman served as appellate counsel in the Antitrust Division of the U.S. Department of Justice, where he worked on U.S. v. Microsoft, among other matters. Sprigman then joined the Washington, D.C., office of King & Spalding, where he was elected a partner. In 2003, he left law practice to become a Residential Fellow at the Center for Internet and Society at Stanford Law School. He joined the Virginia faculty in 2005, where he was a faculty member until he joined NYU Law School in 2013.
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Kamsky wins game 4 to level match score
Gata Kamsky defeated Veselin Topalov in the fourth game of the Challenger's Match to level the score: 2-2. In a Zaitsev Ruy Lopez, the American sacrificed a pawn for strong pressure, won two pawns back and then converted his material advantage in the ending.
The Kamsky-Topalov World Championship Semi-Final Match takes place February 16th to 28th in the National Palace of Culture in Sofia, Bulgaria. The Challenger's Match consists of eight games and possible tie-breaks and has a prize find of US $250,000 which will be shared equally by the players. The winner qualifies for a World Championship Match against Viswanathan Anand.
Game 4
Again, Topalov went for 1...e5 and this time it was the Zaitsev Variation he had prepared. With 12.Ng5 (a move sometimes played back in the seventies) Kamsky avoided the topical lines and then came up with a very creative pawn sacrifice (26.b3) to untangle his queenside. The American had judged correctly: his pressure on the c- and d-files meant more than enough compensation. After a few inaccuracies by Topalov, Kamsky won his pawn back and then another one, and eventually this decided the game. (Don't miss Ian Rogers' great first piece on the events in Sofia!)
Kamsky-Topalov game 4: the final position
Photos © Ivan Stoimenov - courtesy of the official website
"Simple Topalov fanboyism?"
You assume much too much. I'm not his fan. Never has been.
5 years 1 month ago
Hi,guys.I am Bulgarian and I am pretty sure,Topalov will be the next champion!Kamsky is good,but not the best one.Topalov now is the only one who has more then 2800 ELO,none else exept him!The victory will belong to Vesko Topalov!!!!!
Danailov was the driving force behind the Fide offer to Kramnik. You can search for the news items yourself, but I will quote Karpov here, with whom I totally agree.
"Here are the comments from Karpov about this matter:
Topalov´s absence in the next World Championship cycle is scandalously absurd. But we have to remind ourselves of how these strange rules came up. They decided after San Luis by those same people of FIDE that went according to the decisions of Danailov and Topalov. They thought that after the magnificent results of Topalov in 2005, Kramnik simply would not have any chance to win. This was designed to get rid of him definitively. They invented these rules, according to which one of the participants of the match in Elista would not be allowed to play in the following cycle. There is a wonderful Russian proverb: "Do not dig a hole for somebody else, you yourself will fall into it". This exact situation was what happened with Topalov and Danailov. They dug a hole to for Kramnik, but they were those who fell in it."
Danailov has tried to get an anti-Fide image after the match, like he and Topalov were cheated by Fide. The truth is Topalov was the Fide champion and Fide would've done everything to have him win. Remember the toilet tapes they just handed out like nothing? Danailov and Topalov have a lot of friends within Fide, look at how easily they could circumvent their own clause.
You still didn't answer my question, how does agreeing with "No player should get any favor" but disagreeing with "No player should be seeded into the cycle whatever his rating" go together? Simple Topalov fanboyism?
@ pete: I did not say Kramnik deserved the match. But I think it was necessary to end all discussion. Kramnik shouldn't be at the Candidates Tournament (I'm just assuming he will be), just like Topalov shouldn't be playing this match.
@ me: How is it possible to agree with "No player should get any favor" but disagree with "No player should be seeded into the cycle whatever his rating"? Doesn't seem logical to me.
Since you are mentioning the word ilogical. You said:
"It was TOPALOV who wanted a clause in the match contract with Kramnik that excluded the loser from the next cycle."
Where did you get this from? It doesn't make any sense.
Let's see some facts:
1) Before the match, Topalov was directly seeded into the 2007 WCC, while Kramnik refused to participate in the candidates and was thus out of the cycle.
2) If Topalov would have won, his and Kramnik's status in the cycle would remain unchanged.
3) Kramnik won, so he switched places with Topalov - he got Topalov spot in 2007 WCC and Topalov was out of the cycle.
So why on earth would Topalov demand such a clause??? It makes no sence whatsoever. It is far more logical that it was Kramnik (or someone within FIDE who had something against Topalov) who came up with this clause.
Topalov was certainly not the one who came up with it, because he had nothing to gain from it. He could (and did) only lose something. Topalov and Danailov are not that stupid and arrogant.
I think Topalov will play white in game 5. If so I bet on 1-0 and the six game will be also very interesting and important.
Tchigorin and every other Great! It is a myth that Tchigorin really praised knights more than bishops, in general. He had many games in which he exchanges knights and keeps bishops. Now, he praised them, and played them very well, having memorable wins that way, sure.
So far very interesting gaemes. Even the two draws were extremely interesting.
5 years 1 month ago
Excellent game! On ICC there was much stir about whether Kamsky saw 43.Bxf8 with the following 44.Qc1, but apparently he did.
5 years 1 month ago
An extremely nice game by Kamsky.
Looks like Topalov will have to change the course of the match in Round 5, possibly by playing something other than 1.d4.
1.d4 Nf6 2.c4 g6 3.f3 by Topalov might be another good idea, just to get Kamsky out of his comfort zone.
Mauricio Valdes
5 years 1 month ago
score is even and it is haltime.......
the underdog has leveled the match...how cool is that dude?
5 years 1 month ago
I'll be honest: I am no big fan of Kamsky, but I dislike Team Topailov with a vengence.
Hence I am routing for Kamsky, but fear he will not be allowed to win this match.
5 years 1 month ago
This first ever victory over Topalov will certainly give a vital boost to Kamsky´s spirits, which even might even out both players´ chances.
Kamsky has clearly played the better chess so far. Even the game Topalov won was more Kamsky losing than Topalov winning. Strange choice to go for the Zaitsev against Kamsky. I hope Gata can beat Topalov and get the match with Anand he should have gotten right away. He has a good chance after the restday, he has white twice in a row after all.
5 years 1 month ago
Kamsky will be playing White again in R5. Go go and crush Toppy like an ant!
I think game 5 will be played repeting colours, that is, Kamsky - Topalov again.
Kamsky is really a phenomenon, that was already known. What a retirement and what a comeback. From his 14-15 years on he showed he can win games from anyone, and he does it!
And yeah, it looks like this choice for black was realy bad. This is not Topalov's kind of opening at all! I predict Center-counter for game 5 ;-)
5 years 1 month ago
me: "It was known since June 2007 that the winner of 2007 World Cup (played in November/December 2007) will have to play a challenger match against Topalov."
Yes, it was known. But that does not mean that getting into this match is not an absurd privilege for Topalov. In June 2007 the rules were changed in Topalov's favour.
I totally agree with R.Mutt. Topalov shouldn't be playing this match and this is no lie. He used his connections and got seeded, without any reason other than being Topalov. Just because the rules are the rules does not mean they are justified, especially in this case where they were changed mid-cycle (again).
5 years 1 month ago
Very nice game by Kamsky indeed!
b4 seemed to be a mistake indeed, perhaps Topalov got desperate to complicate the game. Qc3 was ok, but according to Dennis Monokroussos, it might be a bad practical decision.
I don't think Qa8 would have made much of a difference. After your line, black can't take the pawn on e4, so white stays a healthy pawn up with a nice position. Black's pawns on b5 and e5 look a lot worse on the other hand. Certainly not equal.
to Peter;
thanks a lot ...
I should check again my analysis after Qa8 .... It seems that it remains bad in view of your positional observations. I am not sure if there remains some tactical resources.
I understand that Topa was aiming to complicate the game with b4 by putting the a5 bishop under fire in next moves.
If Topalov didn't deserve to be in this challenger match then I don't know who does.
1.) He was left out of the 2007 World Championship. It is plain ridicolous to leave the #1 ranked player out of the World Championship cycle.
2) At that time there was a rule that said that any former champion or +2700 rated player can challenge the World Champion to a match. If the prize fund is 1 milion $ then the Champion MUST accept. Topalov did make a valid 1 milion challenge, but Kramnik/FIDE refused on technicality that the guarantees are from the "wrong" bank.
3) Topalov challenges again, this time with guarantees from the "right" bank. Kramnik/FIDE ignores the challenge until it is impossible to play (because of WCC in Mexico)
4) Kramnik miracoluosly gets a free shot in case he loses the title in Mexico. Since FIDE is giving free passes like candies, they give it to Topalov too (but he deserved it much more than Kramnik).
bad day for Topa ... my personal opinion is that the Ruy Lopez does not suit him, he should be playing something more dynamic. Kamsky proved that he really has nerves of steel and his victory was impressive, congratulations.
I hope we will see something more energetic and interesting tomorrow ... like the first two games, this one was too positional for my taste.
@ me: You're wrong. It was TOPALOV who wanted a clause in the match contract with Kramnik that excluded the loser from the next cycle. He was arrogant enough to believe he'd beat Kramnik and wanted him out. What happened is that he was the one on the outside. But instead of competing with others and play for qualification he preferred to use his connections and get a ridiculous seed into the cycle. If the world number one does not want to compete with others (he should be confident enough to get the spot, don't you think?), he should not be in the cycle.
Topalov was not willing to play, he shouldn't be where he is, end of discussion.
I believe it was Fide bringing up the time argument, which is not unreasonable. Remember, had Topalov not included the clause he would surely have been in Mexico, it's his own fault.
Kramnik getting a rematch was necessary, because there are a lot of people who believe World Championship matches can only be decided in matches, not in tournaments. To end all possible discussion a match was needed.
Demanding more candies can not be the way to go. Instead we should seek to abolish all favoritism and keep people out who are not willing to qualify via the cycle. To say Topalov deserved it more than Kramnik is ridiculous. Neither deserves any favors and both are good enough to qualify via the normal cycle, which is exactly what they should do!
the main thing is to respect your opponent but Kamsky can crush Topalov only in your dreams there were no problems for making draw in this position
I do not understand why Topalov gave up his siciliaan najdorf. Now he is playing passive chess: all his pieces where in the third rank until move 26 !!!!
I thinkh that 30. ...b4 was a blunder or even 26. ... Qxc3 poisoned pawn. After this moves, Topa's position was difficult.
I guess that he misses a drawing chance: 41. ... Qa8 42.Bxd6 Red8 43.Rc7 Qa5 44.Rxd7+ Rxd7 45.Nd5 Bxd5 46.Bxf8 Rc7 47.Qd1 about equal.
And the b5 pawn is over protected
"Kramnik getting a rematch was necessary, because there are a lot of people who believe World Championship matches can only be decided in matches, not in tournaments. To end all possible discussion a match was needed."
it is ironic how you blame Topalov for everything, but when it comes to the one you support you close your eyes. Kramink did not deserve the rematch!
I think FIDE should have let Topalov play in Mexico and end all that bullshit with that. Those two matches after 2007 were not needed and only complicated the situation
5 years 1 month ago
Did you notice? Take a look at the position after the moves 49.Rc7 Qd6... I see it as a classical and spectacular example of the Knights Pair crushing the Bishops Pair!! Tchigorin is for sure smiling a lot with this Kamsky game!
"I hope Gata can beat Topalov and get the match with Anand he should have gotten right away."
Again this lie that gets repeated again and again. It was known since June 2007 that the winner of 2007 World Cup (played in November/December 2007) will have to play a challenger match against Topalov. Kamsky, as well as everyone else, knew that in case of win he will have to play against Topalov. And it was also known that the match is scheduled for November 2008 in Bulgaria!
I don't know what's with all of you. You are either ignorant (so please stop talking about things you don't know) or you are deliberatly spreading lies.
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Onsite visits for service have a minimum charge of 1 billable hour. Remote services involving diagnosis or repair of the client's device have a minimum charge of .5 billable hours. Residential service are payable upon completion. Services rendered for businesses are payable by invoice which AVC Technical Services will generate within one week of completion of requested work. Payment is expected within 15 days of receipt of invoice. An additional late penalty of 5% of the invoiced amount will be added if payment has not been received within 30 days. Payments that have not been received within 90 days will be submitted to a collection service. Clients requesting hardware purchases of $1000 or more may require a payment of half the total invoiced amount at procurement with the remaining due upon delivery.
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An original can be found in the Old Sturbridge Village collection in Massachusetts. With reflective backplates, the circular form of this early and popular lighting style dates back to classical antiquity.
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