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The Apo-ONE™ Homogeneous Caspase-3/7 Assay features high sensitivity, versatility, and minimal reagent preparation time. The system's inherent flexibility works in a broad range of assay volumes and is readily automated on the Beckman Biomek® 2000 for high-throughput caspase detection. The Apo-ONE™ Assay provides reagents optimized for the detection of apoptosis in both cell-based and purified-enzyme systems. Here we describe the use of Apo-ONE™ Homogeneous Caspase-3/7 Assay in 96 and 384 well plate formats for screening potential therapeutic agents that induce apoptosis.
Promega Notes 79, 33–35.
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Not really a fan of multiplayer DLC packs. Seems harder to get as much value out of them.
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Not really a fan of multiplayer DLC packs. Seems harder to get as much value out of them.
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There's nothing friendly about the fire that's happening here, but it sure looks like fun.
Brad and Jeff are joined on the couch as they chill to the smooth moves of the "Long Mover."
No more vomiting blood! I won't have it.
I don't know if the scars are healed from Colonial Marines yet, but I'm trying to keep an open mind. They're SAYING all the right things, at least.
And something tells me you guys are really gonna like how this video starts.
Instead, the developers of Anomaly are taking a closer look at the citizens in a conflict.
Vinny constructs his ideal universe of cars and beds in version 0.5.5 of this planetary oddity.
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It's time to learn to love the bomb.
The creator of the profoundly creepy Home is now interested in making you fall in love. Maybe.
Prepare to look into the eyes of cutesy madness.
Prepare your synthesizers, people. (I've also been looking forward to this for years. Here goes nothing!)
With the release of Dark Souls II, we've got to find another reason to play it in the office.
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We don't need Cain to pray at the altar of Lord Gamblor.
As if you needed reminding. Still, this trailer's worth watching if only for the unexpected Jethro Tull song.
It's the early days of a Souls game, so Brad and Vinny haven't yet learned to avoid giant stake cannons.
There appears to be a hole in the ground. Let's go inside!
The emotional first-person walking simulator is coming later this year.
Something about this video is making me never want to eat candy again. Looking forward to the game, though.
We prepare for Titanfall by spending more time with South Park, staring at a Dark Souls 2 box, and wondering about Sony's VR plans.
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Volvo Trucks is now presenting an engine tailored for the tough Euro 6 environmental standards. Nitrogen oxide emissions have dropped by 77 percent and particulate emissions have been halved. First off the mark is Volvo's D13 460 hp engine, which today powers more than one-third of all Volvo trucks.
AB Volvo divests the Group's subsidiary Volvo Aero to the global engineering company GKN for an enterprise value of SEK 6.9 billion."GKN is a strong new owner for Volvo Aero," says Volvo's CEO Olof Persson. "GKN will provide Volvo Aero with the best possible conditions for continued advancement in its industry."
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The number of votes in AB Volvo has changed due to the conversion of a total of 16,500 Series A shares to a total of 16,500 Series B shares. The conversions were implemented with the support of the opportunity for Series A shareholders to request conversion of Series A shares to Series B shares, which was entered in the Articles of Association at the 2011 Annual General Meeting.
The truck industry is searching high and low for solutions that cut fuel consumption. One method is to use the vehicle's kinetic energy to propel the truck. Now Volvo Group under the brand Volvo has developed I-See, which operates like an autopilot and takes over gearchanging and utilises gradients to save fuel.
On June 12, the Volvo Group opened its new base of operations in Peru. With a total area of 56,500 square meters, the facilities will serve as a hub for commercial and after-market activities supporting Volvo, Mack and UD vehicles, Volvo Buses, and Volvo Penta marine and industrial engines. US$ 17 million is being invested in the new facilities.
Total deliveries from the Volvo Group's truck operations in May 2012 amounted to 19 734 vehicles. This was a decrease of 3% compared with the year-earlier period.
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Excavators without drivers, virtual sheet painting and electric buses that charge in ten minutes. The Volvo Group is opening the door to the future with its new Tech World website. For the first time, many of the research projects on which the company's engineers are working will be openly displayed.


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Kate Schmidt weighs in: Legitimize PEDs
This Forum was created to divert traffic from Current Events at the height of the BALCO scandal. It comes and goes as "needed"; it's back to being locked.
23 posts • Page 1 of 1
Kate Schmidt weighs in: Legitimize PEDs
Perhaps I missed it on these boards, but I'm sure others besides me saw the LA Times Sunday Opinion Section piece by Kate Schmidt, in which she explains why the criticism of MJ is unfair and calls for legalizing limited use of PEDs. Not a popular view, but fearless individuality has always been part of why she was called Kate the Great.
http://www.latimes.com/features/health/ ... 5532.story
The next day LA Times columnist/writer Helene Elliott wrote a rebuttal of sorts:
http://www.latimes.com/sports/la-sp-ell ... 074.column
Elliott's rebuttal had a lot of good points, but she severely damaged her case in my eyes by playing the "everybody's going to die" card.
I found it interesting that Kate (for whom I'd be willing to swear on the stack of proverbial bibles I'd believe to have been 100% clean), who almost surely had her Olympic medals of both '72 and '76 diminished--and numerous World Rankings spots deflated--by EastBloc usage, isn't full of the typical "I want my medals" rage of so many of her compatriots.
and here is another interesting link to a journal article proposing leagalising doping (under medical supervision). It is a good read.
I would consider myself very against doping, but I have to admit they bring up interesting points and valid ideas.
Despite their ideas, and without going into a long post about ethics I would agree with most of the rebutal by Elliott
1) no one wants their kids to have to choose between taking large amounts of drugs or not being able to compete at an elite level
2) I think people are seriously kidding themselves if they think athletes will take "safe" amounts of drugs once allowed. Greed and money always take over (just as they do now) and they will take larger and larger doses to make sure they keep wining and eventually this will result in disaster.
If the "level playing field" becomes one where controlled drug use is permitted - then athletes will just seek to make it unlevel again by using even more dangerous drugs and larger doses resulting in disaster (but some damn impressive performances!!!).
plus - how would you ever police the fact that an athlete was required to use medical supervision for doping? You think the poor Nigerian sprinter trying to make the Olympics is going to take a safe level of Stanozolol with careful medical supervision????
so given you don't have a level playing field either way and you can't police either option - then I for one choose the anti-doping path, acknowledging that many athletes might escape the testing - but it is much better than the alternative mentioned in the above articles IMHO
Exactly, it will always be negative selection. Perhaps most athletes will not want to kill themselves to succeed, but there will always be a few despeate enough (for whatever reason) to take the risk, and we'll end up with a situation where those taking only reasonable doses will no longer be competitive. That's why a free-for-all is a terrible solution.
My position is (and has fo a long time been) the following:
- Introduce cut-off limits for all PEDs. If drugs are found in you body in amounts lower than the limit, you're fine.
- Get rid of random testing. Test all top athletes at defined intervals - say every month. You could require them all to show up in the lab on a prearranged date - it would substantially reduce the cost of administering the program compared to what we have now.
- Put emphasis on protecting athletes' health, not on the moral issues. If the athlete is found with 'illegal' quantities of drugs in their system, they should not be allowed to compete because it puts their health at risk, not because they committed a sin or a crime. Give short bans - not more than a few months. That's enough of a punishment for people who depend on competing to make a living.
Do that and nobody who is properly advised will ever test positive, even those who have been training with the use of PED's.
That is exactly my position. I believe that there ARE safe amounts of PEDs, and I don't believe everyone on steroids is going to become the next Lyle Alzado (whether steroids did or did NOT do him in), but my fear is not the USE of PEDs, it is the ABUSE of PEDs, and people, being people, will say 'more is better' and then many WILL incur serious health issues!! That is also my position on rec drugs. Ya wanna drink, smoke dope, drop pills? Knock yourself out, but do so at your own risk. People ABUSE alcohol and rec drugs and then put me and my loved ones in harm's way (sometimes having little to do with their actual behavior under the influence). That's a BIG problem to me.
You missed the whole point of me scheme: the aim is not to eliminate all use of PEDs. It's to make sure the athletes limit their use to reasonable quantities.
Most people seem to think there are only two options: either no-tolerance and treating PED users as criminals or a complete free-for all. I believe the latter is a terrible idea (as I explained earlier), and the former is too expensive and leads to T&F losing popularity.
Last edited by Powell on Wed Oct 17, 2007 8:31 am, edited 1 time in total.
Last edited by Mats Nilsson on Fri Mar 14, 2014 6:10 pm, edited 1 time in total.
In a way you can already see you plan put in place in a limited way in sports like cycling and skiing. They have the "no-start rule" used in conjuction with blood parameters. In effect they are saying "ok we know we can't really catch you cheating, but as long as you keep your levels below this 'safe' figure then we will allow you to compete. If you are above you can't compete for the next 7 days". In fairness it seems to work to me and not many people seem to have complaints
I guess what you are advocating is that this is extended to all drugs and with more regular testing (not just before a competition). I have to give merit to any ideas as the current sytem isn't working - although I still maintain that greedy athletes will find ways around any system that is put in place.
So the question becomes how often would you do the regular testing in order to be sure they are not abusing the drugs? 6 times a year, once a month, once a week., twice a week?...in the end I think it becomes nearly as time consuming and nearly as expensive as the current system and we are back at the start again!
i think cycling had to go that route because epo test only works for a few days after administration & therefore chances of getting a +ve epo test is low
however, it's effects of a high haematocrit last for a few weeks - which is what the auhorities can pick up, but without an epo +ve, there is no viable case for doping to be made ( cyclist can claim high haematocrit was due to training at altitude )
if/when thy develop an epo test which can detect drug use for maybe a few weeks after admin, maybe they may change the high haematocrit rule
The IAAF, taking a similar approach whereby individuals demonstrating inexplicably high blood levels marked against their own profiles would, as is the case with cycling mentioned above, be subject to a "no-start rule".
The "no-start rule" would not be a banning for suspicion of drugs usage, rather would be a signal that medical grounds call for further sample investigation from the athlete. The athlete would be inactivated from competitions pending the analysis of the new testing against the individual stored profile.
have they formally set up profiles ?
even if so, it's a trcky call - you'd need to unequivocally demonstrate haemotricits can only push well over 50 with epo & not altitude training alone, otherwise innocent athletes will be prevented from competing
http://www.iaaf.org/newsfiles/36362.pdf (both quotes excerpted from a 53-page document)
People are inherently good. If you just ask them nicely not to do bad things, they won't. Everyone is altruistic first, knowing that if everyone takes care of everyone else, they won't have to take care of themselves.
or so I wish
The situation wouldn't be much different than it is today, but with much less pressure on the athletes.
It's all a game anyway. To much rules ruins any game. I'm calling for less pedantry and more honesty.
This is foremost about how organizations and over-zealous fans wants to rule the athletes lifes. Some do it by lobbying for a position in an organization, other, less shrewd ones, do it by having their say on message boards.
It always surprises me how the fans call on the organizations to protect them from "bad athletes". As if these organizations have their mandate directly from the gods. Of course, the over-zealous fan wants to play god himself, so I guess you could say he knows what he is doing.
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My son is 7 weeks old and I really wanted to breastfeed him since my milk actually came in because it didnt come in with my first son. At the hospital he was latching good, but it took me a couple days to produce the milk he needed so I started pumping and decided to put what I pumped in a bottle. I wanted him to get used to a bottle because I knew I would have to go back to work eventually. At first I was producing enough milk for him, but now I am not and I have to supplement with formula. I am back to work now and have to use my lunch breaks to pump because I don't get to otherwise. I really wanted him to have all breast milk for at least 6 months or longer, but I know I have to supplement so he gets fed well and grows. I am going to pump as long as I can.
First of all, KUDOS to you for continuing to pump and offer your breastmilk. It is very hard when you go back to work to really keep production up. The benefits of breastmilk are still being given to your son when you provide your immunity and nutrients with some of the breastmilk you give him! Keep nursing him as often as you can at home to help ramp up supply and continue the pumping at work. All the guilt you are feeling is so sad to me - you are obviously a very dedicated and loving mother. Your kids could not ask for anything more! Don't beat yourself up over something that is beyond your control and just take pride in offering him what breastmilk you can. Hugs to you!
I struggled with breastfeeding my first child and gave up after a month. My daughter was born in August and I was determined to try again. She is now 8 weeks and I'm still struggling. I feel like she is making a good latch, but it's still very painful every time she nurses. From the beginning I've had to supplement with formula, especially at night because she is so hungry and wants to eat every 45 min!! During the day she seems to get enough and is nursing about every 3 hours. I have tried pumping but with little luck, usually I get less than 2 oz total. I have tried taking Fenugreek, eating lots of oatmeal and grains and drinking lots of water. Maybe it's just not meant for me? I've become so stressed about it that I don't look forward to feedings at all :( I know that there is nothing wrong with feeding formula only, but I guess it's maybe maternal instinct that makes me want to keep up with the BF
It is hard to stop breastfeeding, but sometimes things don't always go the way we planned! Luckily, we do have the option to offer our babies another alternative. Don't stress out and try to take the pressure off of yourself. Your baby is getting all the nutrition she needs. Good luck and know that you are not alone!
Congratulations mommy! You should not feel guilty! Your intentions were good! Some mothers are not even concerned with breastfeeding their baby at all, you did it, and you wanted to give that experience and nutrition to your baby. Way to go! It is wonderful that you were able to do it for the time that you did. I am sure that gave your baby just what she needed. I am sure that your baby will always have the best because you are a concerned mother. Never feel guilty when you have to make changes and choices so that your child will receive what he/she needs.
I know there's already been a lot of comments on this post but I just wanted to let you know you are not alone . i'm in the same boat and feel guilty too. But after several weeks of wrestling with the guilt ..all I can say is that your baby is healthy and growing is most important. My baby didn't have a weight gain issue but I just a supply issue from day 1 and I just couldn't provide for him no matter what "tricks of the trade" I tried. I'd get about an ounce to ounce and half total from both breasts after each pump session. He's pretty much been on formula since birth and he is healthy and growing like a weed. He's 7 weeks and grown out of half of his 0-3 mos clothing. Breast is best...but formula is not bad either.
I too had the same problem but still am. Baby is 4 weeks old now. Pedi told me to stop nursing for fear of baby having gerd and not gaining weight. I am still hopeful to be able to nurse but doing what the dr said to do. I have no support from my hubby or inlaws, they just want me to nurse and not go by the drs orders, I fear something bad will happen to my emotions if I dont get the support i need.
Are you having a better adjustment now from nursing to formula?
before I give a detailed answer and maybe look silly ..was the question meant for me?
HI I'm a first time mom. I also had a c-section with my daughter Sarah and I tried to Breastfeed and nurses were strongly against formula. My daughter and I were getting frustated with the Lactation nurse so we decided to give her formula... The pediatrician was okay with my decision...
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MOUNT PLEASANT – On Wednesday, April 17, at 6:35 p.m., the Chippewas and Michigan State Spartans will square off in The "D" for the third annual Clash at Comerica.
This annual highlight of the college baseball schedule in the state of Michigan has two of the state's historically successful programs squaring off in one of the finest baseball venues in the country.
The Clash at Comerica also provides an opportunity for CMU's strong alumni base in southeast Michigan to see the maroon and gold in action right in their backyard.
Tickets cost $6 for adults, $5 for youth/seniors and $3 for any college student with a valid student ID. Groups of 10 or more may also purchase tickets at a special group rate of $3 per ticket.
There will also be a special reception held in the Tiger Club for CMU alumni, supporters and their guests starting at 5 p.m. Chippewa fans are invited to enjoy tailgate-style fare, a cash bar and will hear a preview of CMU's matchup with the Spartans from Head Baseball Coach Steve Jaksa.
The cost of the event is $20, which includes dinner a game ticket. The reception is sponsored by the Chippewa Athletic Fund and CMU Alumni Relations.
All tickets, including tickets for the pre-game reception, may be purchased from CMU's Ticket Central by calling 1-888-FIREUP-2 or online.
Game tickets are also available through the Comerica Park box office.
Fans may park in structures near the stadium for $6 and enter through the main gates, located off of Witherell St. and Elizabeth St.
We hope you can make the trip to Detroit and watch the Chippewas and Spartans in the Motor City!


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Paper Flower Fans
Create this clever pinwheel decoration for your wedding day. All you have to do is layer pinwheels as desired, embellish with buttons and punch paper for a scalloped effect.
Designed by the Michaels Design Studio.
Material List
- Scrapbook Paper, 12"x12" (8) – Color and Design of Choice
- Decorative Edge Punch – Design of Choice
- Recollections™ Adhesive, Tacky
- Martha Stewart Crafts™ Scoreboard
- Chipboard
- Low Heat Glue Gun
Project Instructions
Large Pinwheel (2' Across)
Punch the edge of each sheet of 12"x12" paper (if there's a pattern, make sure to punch along the edge of the paper, keeping pattern in the same direction).
Score each sheet (keeping pattern in the same direction) at 1" intervals, using the scoring board and the bone folder.
Using adhesive tape, secure each sheet together to make one long piece. Attach the ends together to make one big loop.
Cut a circle of chipboard about 5-6" (freehand cut). Lay the giant scored loop on a flat surface and form the pinwheel front side down. Pull the pleated circle in so that the open circle in the center is about 2-3". When happy with the shape, hot glue the chipboard circle to the back and let cool.
Medium Pinwheel (12" Across)
Cut four strips of scrapbook paper 6"x12".
Punch one edge using a decorative edge punch.
Score at ½" intervals.
Follow directions above, adjusting the chipboard circle to fit.
Small Pinwheel (7" Across)
Cut four strips of scrapbook paper 3½"x12".
Punch one edge using a decorative edge punch.
Follow directions above adjusting the chipboard circle to fit.
For other pinwheels, determine the final size of the circle desired. Your strips will be ½ of that width.
5" Circle, two strips 2¾"x12"
4" Circle, one strip 2"x12"
All Pinwheels
Stack and layer pinwheels as desired. Hot glue together at the centers.
Embellish as desired.


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Both Sides of the Fence
A Tosa resident since 1991, Christine walks the dog, cooks but avoids housework, writes and reads, and enjoys the company of friends and strangers. Her job takes her around the state, learning about people's health. A Quaker (no, they don't wear blue hats or sell oatmeal or motor oil), she has been known to stand on both sides of the political and philosophic fence at the same time, which is very uncomfortable when you think about it. She writes about pretty much whatever stops in to visit her busy mind at the moment. One reader described her as "incredibly opinionated but not judgmental." That sounds like a good thing to strive for!
A happy Valentine's Day
I left work a little early today to grab some more of the light and the mild weather than my usual day allows. And to give my faithful love, Idgie, a decent walk for Valentine's Day.
The good thing about not having a romantic partner, if there is a good thing about it, is that you get to love more clearly all the rest of whatever it is you are given to love. This rescued dog, these children now grown, those neighbors and chance acquaintances, you friends who know me and let me know you back.
We walked the Underwood Creek Parkway as we often do. And though the sky was cloudy, the most wonderful colors hid among the grays. I felt a little sorry that dogs, except maybe the birding kind, don't raise their heads up much, except to catch a windbourne smell, a sharp sound.
There was one of those: sudden, high, bright. A child's voice. I can't remember the last time I saw children playing here. But there they were, this boy, about eight, and this girl, a little younger, cautiously making their way down the concrete walls of the creek. They'd come through the maple bog and crossed the railroad tracks, and now they were investigating the ice edging the water.
"Look," the boy yelled, excited. "It's pretty!" He paused, bent to examine something, and shouted again: "It's pretty!"
I don't know what he saw, but I hope the girl saw it too, and I hope she felt the same delight. Leaves layered and frozen in translucent ice, maybe, or the brittle, lacey, clear kind of ice that breaks in fractal patterns.
I think I know just how he felt. In the most unexpected places, you are seized by joy or love or wonder--or by all of those.
"It's pretty," your heart says, all on its own, without having to be taught.
I waited a bit, a little worried that these children might not know how to handle themselves even in such tame wild places. I'm a mother: that's what we do. But a woman followed them down to share what held their attention.
A little spring hopey-changey in the air?
It's been feeling like a strange and wonderful early spring around here, and the asparagus ($1.99 on sale at Sendik's) and the rhubarb (foraged from the County Grounds) pie we had for dinner last night helped that hopeful feeling along.
If I put up enough filters to the onslaught of information and disinformation, I can even feel a little hopeful about our political climate.
Can it be that more people are looking at even their "own guys" and saying "wait a minute. What's going on here?" Milwaukee Journal Sentinel columnist Mike Nichols writes ". . .here's what I don't understand: How come more conservatives--who, like me, believe Walker did the right and necessary thing (regarding unions)--don't look at Russell and scream?"
Timothy Russell was now-Governor, then-County-Executive, Scott Walker's aide. He's part of a still growing John Doe investigation into illegal campaigning and misappropriation (that would be theft) of funds. As Nichols, a conservative think-tank fellow, says, it's that stuff and not the union busting stuff that could take a governor down.
A little sneaky illegal action on the side is no big deal to insiders, for whom, too often, dirty pool is the only way the game is played.
But for the rest of us, who try to be decent and honest, having people do your not-quite-right or downright wrong work for you while you turn your back (and in this case, finding they are doing a little dirty work you may not have known about on the side) taints you, too.
If you'd asked me a month ago I'd have said Scott Walker is probably really as squeaky clean a guy as he seems. No hidden mistresses, no closet surprises. I'd still bet that about his personal life.
But when you start to live by the belief that the end justifies the means and make compromises accordingly, you lose your shine. Making sure you don't know what's going on damns you when people start to put bits and pieces together.
Now here's the hopey-changey part. With neither party doing any kind of stellar job for us (that would be the people) or our economy, we're starting to think harder about fairness, honor, and actual effectiveness. We're starting to question the claims and rhetoric we've accepted unquestioningly. This means going beyond blind party loyalty.
In the same Milwaukee Journal Sentinel issue, BadgerStat performance measurement guru Andy Feldman sets some criteria for deciding who to support for Wisconsin's governor. They could be adapted to any candidate for any office.
1. A leader who is willing to speak candidly about the strengths and weaknesses of public employee unions and who supports legislation that reflects both.
2. A candidate who wakes up every morning thinking about how to help grow jobs in Wisconsin but who understands that some economic development policies are much more cost-effective than others.
3. The candidate who advocates most strongly for (non-partisan reforms that would give more power and information to the Wisconsin citizens and taxpayers).
More power and more real information to the people! Now there's a concept. Of course, when we get it, all of us need to call out our own guys and not just the other guy's guys when they fail to be honest, above-board, or take responsibility.
Not sure whether we have to scream, though. My guess, we can do it strongly and firmly without resorting to distortions and hysterics, even though we haven't had a lot of models for doing so lately.
Vote--and remember to bring your ID
Today's your chance to help narrow the field of competent, promising candidates for mayor of Wauwatosa. There's a county supervisor seat and, depending on where you live, you might be able to do the same thing for your city council representatives.
You'll need your ID this time. I don't expect that will make much difference here, but it will be interesting to watch the experience in communities with larger or more transient populations.


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DecoArt® By the Dozen Santa Ornament
This cute little santa will spread the holiday joy as an ornament, package tie, magnet or adhered to another surface. He's quick and easy to make.
Designed by Julie Gayle courtesy of the DecoArt® Design Team.
Material List
- DecoArt® Americana® Acrylic Paint – Santa Red, Snow (Titanium) White , Lamp (Ebony), Black and Flesh Tone
- DecoArt® Snow-Tex™
- Woodsies™ Shapes – XXL Heart (1), Medium Hearts (3), Small Hearts (2), Medium Rectangles (4), Small Circles (2) and Small Teardrops (2) Craft Sticks, Mini (2)
- Permanent Marker, Extra Fine – Black
- Paintbrush – ½" Flat Brush
- Emery Board
- Water Container
- Wax Paper
- Paper Towel
- Toothpicks
- Glass Jar Wrapped with Ribbon (Optional)
Project Instructions
Paint the wood pieces as shown in the photo.
For the nose, mix a little Santa Red into Snow White paint to create a pink, then paint one small circle pink.
Referring to the photograph, glue the wood pieces together as follows:
Body: Glue one rectangle to each corner of the back of one XXL square.
Head: Glue mini craft stick across the bottom of the red area on the XXL heart.
Glue two small teardrops to the heart above the center "dip", then glue the small circle on top.
Glue the second XXL square on top of the first, then glue the "head" in place at the bottom of this square. Glue the white heart in place (on the arm) at the base of the "head" for the beard.
Glue the second mini stick across the top edge of the square.
Boots and mittens: Glue a small hear behind each end of the "arms." Glue a medium heart behind the ends of each "leg."
Hat trim: Glue the small white circle to the point of the large heart.
Using the end of a paint brush handle paint the eyes. Let dry then, using a toothpick, add a tiny white dot to the upper edge of the black dot.
Paint over the white areas with Snow-Tex™ to create texture for the fur trim on Santa's suit and his beard and mustache. Let dry then paint over with Crystal glitter paint.
Glue a ribbon hanger or magnet on the back of the Santa, or use him to trim another surface like the glass candy jar shown.


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Miller's Pensacola Ale House
Welcome to Miller's Pensacola Ale House! Located on N. Davis Highway near Airport Boulevard, the Ale House restaurant provides top-quality food at a great value.
Can't decide between a steak, fresh seafood or Buffalo wings? Our restaurant menu has it all – from New York Strip to lobster, original pastas to fresh salads, and favorites like Zingers® boneless wings and homemade desserts. Our full-service bar features more than 75 beers, as well as wine and liquor.
Pensacola Ale House is your casual neighborhood tavern. Bring the family, watch the game with friends, lunch with co-workers – however you come to relax, you will have a good time and great food at the Pensacola Ale House.
This Month's Pensacola Ale House Specials
Daily Lunch & Dinner Specials Download this month's daily lunch and dinner specials. Includes great on sandwiches, seafood, steaks and more! Download PDF
Pensacola Ale House News
COMING SOON: Miller's Henderson Ale House!
Opening soon, our newest location in Henderson, NV. Located at 594 Stephanie street. Check back for more details on the future opening date!
NOW OPEN! Commack Ale House
Our newest Miller's Ale House location in Commack, NY is now open, stop by for a drink and some World Famous Zingers®!
Newest Store, Staten Island NY
67 locations, and growing! Our newest store in Staten Island NY is now open. Stop by and try some world famous Zingers!
Miller's Ale House Holiday Hours
Participating locations open for Thanksgiving and Christmas. Please contact your local store for holiday hours.
Winner - Zingers for a Year!
Congratulations to Gary Woods from Oviedo FL, our September winner of Zingers for a Year. You can enter to win free Zingers for a year just by signing up for our Raving Fans Club! Plus, you'll get special offers exclusively for our Raving Fans! Sign up here and you'll automatically be entered to win!
Winner for August - Zingers for a Year!
Congratulations to Nancy Marczyk from Elmira NY, our August winner of Zingers for a Year. Nancy exclaimed that we are her favorite stop when in Florida. You can enter to win free Zingers for a year just by signing up for our Raving Fans Club! Plus, you'll get special offers exclusively for our Raving Fans! Sign up here and you'll automatically be entered to win!
It's Miller's Time; Ale House Opens in Lake Grove
After a few delays, Miller's Ale House officially opens in former Houlihan's spot. Read full news here
Join Miller's Ale House in helping these fallen heroes
Last Sunday, 19 Firefighters lost their lives while trying to extinguish a blaze to protect the small town of Yarnell, Arizona.This tragedy marked the country's biggest loss of firefighters in one wildfire in 80 years. The incredible commitment of the fallen Arizona firefighters has inspired Miller's Ale House to get involved in helping the surviving family members. Join Miller's Ale House in helping these fallen heroes by adding a small donation to your next Ale House check.
Click to Open Flyer
Rego Park (Queens) NY Ale House Now Open!
Miller's Ale House is proud to announce the opening of our 64th location in Rego Park (Queens) New York. Located near the intersection of Horace Harding Expressway and Junction Boulevard on the ground floor of the Costco/Kohl's complex. Come on down and enjoy some quality food and drink with some friends!
We Love You Watertown!
50% off for our Law Enforcement&Fire Department Heros of Watertown
Miller's Watertown Ale House would like to recognize all of the Law Enforcement Agencies & Fire Departments who selflessly risked their lives protecting the citizens of Watertown. See how here!


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Enterprise Architecture
Protect Apps, Not Just Data: Enterprise-class BC/DR in a Virtual Environment
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Protect Apps, Not Just Data: Enterprise-class BC/DR in a Virtual Environment
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Dave Simpson, Analyst, The 451 Group; Mark Montagna, The Philadelphia Contributionship; Gil Levonai, VP of Products, Zerto
Enticed by the promise of greater availability and flexibility at a reduced cost, enterprises are virtualizing tier-one, mission-critical applications now more than ever. Those applications are typically comprised of several virtual machines, span servers and storage arrays, have aggressive service-level agreements (SLAs), and require robust, effective and automated failover and failback. Unfortunately, traditional business continuity/disaster recovery (BC/DR) approaches are complex, rigid and inflexible, and IT departments have struggled to protect these applications in a virtual environment.
Want to learn how to mitigate data loss, minimize RPOs and RTOs, and ensure a high degree of service continuity? Join this interactive webinar and discover how to protect your applications, not just your data.
•Leading 451 Group Analyst Dave Simpson will discuss the industry drivers for virtualized mission-critical applications, core challenges of traditional BC/DR approaches, and the key features needed to ensure a robust, yet flexible, BC/DR solution for a virtual environment.
•Gil Levonai, VP of products for Zerto, will quickly highlight a revolutionary technology, hypervisor-based replication, which simplifies enterprise-class BC/DR in a virtual environment.
•Your peer, Mark Montagna, IT Infrastructure Manager for The Philadelphia Contributionship, will share his experience including: previous BC/DR challenges, selection process, the Zerto implementation and resulting benefits.
Jun 13 2012
48 mins
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Data Center Transformation
May 14, 2014
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Flash is the hottest technology in the storage industry today. But with all its touted advantages, there are some challenges – including how to effectively measure the performance benefits for your own environment.
Although flash can be expensive, most of the flash-based storage arrays implement sophisticated compression, deduplication and pattern reduction processing to minimize the amount of data written to flash memory in order to lower the cost per GB and extend the life of flash memory.
Effectively measuring the performance of flash arrays requires more than the basic freeware benchmarking tools and following the steps documented by the SNIA SSSI specification. It requires the need for specifying complex data patterns in these data reduction technologies. Measuring performance without taking these features into account could falsely overstate the performance of a flash array by a factor of 2 or more.
Attend this presentation to learn how to best validate the performance of your potential flash storage arrays in order to optimize costs and mitigate risk.
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Can ServerSANs replace the physical SANs and disk arrays the way virtual servers have replaced their physical counterparts or are ServerSANs a niche solution for remote offices and SMBs? Either way it's clear this new technology should be in your storage solution bag of tricks.
In this presentation we'll explore the common elements ServerSAN solutions have and compare some of the leading solutions and their unique solutions to common problems like fault tolerance and data protection.
The Software-defined Datacenter in a Hyperconvergence World
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In today's data centers, the need for flexibility and agility is undeniable. As businesses continue to grow and leverage technology to remain competitive, they require a new way of simplified IT. IT organizations can no longer deal with complex, cumbersome legacy infrastructure that can't keep at the pace of the business.
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The emergence of "the Cloud" has introduced unprecedented levels of automation and virtualization to the data center environment. The Cloud is now maturing to virtualize network functions along with the computing resources. Understanding orchestration is imperative for succeeding with Software Defined Networking and Network Function Virtualization
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- What does the "Next Gen Datacenter" look like
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May 7 2014
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This is a continuation of our 2-part series on Big Data Visibility with Network Packet Brokers (NPBs).
Big data techniques and technologies can be powerful tools for scaling network monitoring and forensics. They can also facilitate new use cases for network data, potentially beyond the scope of Operations.
Gordon Beith, Director of Product Management at VSS Monitoring, will discuss practical considerations for migrating to a Big Data Visibility Architecture, including:
• Accommodating network volume, velocity and variety using sophisticated hardware preprocessing and APIs
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High availability has traditionally required virtualization and a SAN. Then came virtual storage appliances (VSAs) which were managed like a physical SAN but ran as a virtual machine. Now comes hypervisor convergence, the latest trend that eliminates the entire concept of a SAN, both physical or virtual. Is this hype? Or can this latest technology save you time and money? Let Scale Computing show you how HC3 can radically change your environment for the better.
HC3 represents the cutting edge of infrastructure innovation: A highly available platform with the scalability of the cloud and the security of your own servers, coupled with a radical reduction in both upfront costs and TCO. No more VMware. No more SAN. No more headaches.
Leveraging a Big Data Model in the IT domain, Part 1
Apr 30 2014
5:00 pm
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This is part 1 of our 2-part series on Big Data Visibility with Network Packet Brokers (NPBs).
Even as network data has exploded in volume, velocity and variety, network monitoring solutions have been behind the curve in adopting new technologies and approaches to cost-effectively scale and accommodate a widening virtualization trend. Customers are demanding greater freedom in how applications are deployed and are moving to a consolidated, shared model of data using big data frameworks, such as Hadoop, which enable large-scale processing and retrieval for multiple stakeholders.
Join Andrew R. Harding, VP of Product Line Management at VSS Monitoring, as he discusses:
- Big data and its implications for network monitoring and forensics
- Why network monitoring solutions are lagging from a virtualization standpoint and why this is a problem for network owners
- How certain traditional network monitoring functions will eventually be offloaded to adjacent technologies
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Top 5 Ways for IT to Improve Database Performance
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Mike Matchett, Senior Analyst, Taneja Group
The performance of databases often slows as data and business grows, users find new and demanding ways to leverage applications, and those applications mature and expand in functionality. Whenever a key database slows down, SQL or NoSQL, the business damage can be widespread and it usually becomes a high priority effort to remediate.
At Taneja Group we've noted 5 major ways that IT operations can improve database performance, including a couple of quick and ready ideas that impose little risk or cost. In this 30 minute webcast, we'll look at why IT operations often gets the responsibility for database performance, and the IT-centric options they can pursue.
Mike Matchett brings to Taneja Group over 20 years experience in managing and marketing IT datacenter solutions particularly at the nexus of performance, capacity and virtualization. Currently he is focused on IT optimization for virtualization and convergence across servers, storage and networks, especially to handle the requirements of mission-critical applications, Big Data analysis, and the next generation data center. Mike has a deep understanding of systems management, IT operations, and solutions marketing to help drive architecture, messaging, and positioning initiatives.
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60 mins
Greg Elkinbard, Mirantis & Russ Lindsay, StackVelocity
Frictionless access to information makes everyone think they can do this at home. But, in fact, deploying OpenStack on optimized hardware presents a hatful of challenges that your infrastructure team might not have thought about.
In this session, we'll look at a range of challenges that can stop your project before it makes it to deployment. The session is divided into two topics that we'll dive into:
(a) Introduction to scalability techniques: clouds from a hardware perspective.
Building a large cloud is more than just throwing hardware into a hall and lighting it up. Network, storage, compute and scaling strategies must be designed in from the beginning. In the current state of the art of OpenStack, some decisions are easy to unwind later on and some are impossible. This portion of the presentation will focus on describing the steps you need to execute to build a successful cloud and which decisions you can push off to later.
(b) The second section of the session will focus on strategies to simplify the optimized hardware experience. If you're assembling racks on onsite, you need a plan to deal with everything from cabling and airflow to the NIC firmware and drivers. Each of these details can delay your project and run up costs. We'll also look at the trend toward scalable rack-level units that are factory integrated and tested.
Attendees will also learn about some of the simple things that are obvious with enterprise hardware but can be challenging in any optimized hardware environment. Examples include power on/off, power monitoring, system health/event monitoring, remote console access.
You'll leave this session armed with practical knowledge about running OpenStack on Open Compute and other optimized hardware.
BYOD Challenges, Recommendations & Best Practices from Box
Apr 24 2014
40 mins
Karishma Kothari, Box; Vish Mittapalli, Box
85% of enterprises permit BYOD, but only 25-30% of them actually have policies and technology to manage these devices. What is your business doing to ensure that the content on that device stays secure, regardless of what device your employees are using? If you are considering moving to a BYOD strategy or are in the midst of doing so, join this webinar to learn how to develop and execute a BYOD plan in your company. We'll talk about major challenges from creating a BYOD strategy and best practices from ensuring that the content on your device stays secure with Box.
The New IT - How the World of Work is Changing and What IT Needs to Do to Adapt
Apr 23 2014
60 mins
Jacob Morgan, Co-Founder Chess Media Group; Ben Haines, VP/CIO, Box; David Baker, CSO, Okta
The future of work sees changes to how employees work, how managers lead, and how organizations are structured. However, technology still remains the central nervous system of organizations and things like enables flexible work, collaboration, communication, and BYOD. In short, IT helps organizations be competitive. But how is IT changing in the context of new work behaviors and expectations, a multi-generational workforce, the cloud, globalization, and many of the other trends that are shaping the world of work? Join us in this session as a panel of experts debates and explores how IT is changing and what the future of IT looks like.
How to accelerate your SaaS development using PaaS
Apr 23 2014
44 mins
Mark Eisenberg, Cloud Thought Leader and Strategist; Nitin Agarwal, CEO, Motifworks
As more and more software product companies are looking to migrate their traditional on-premise software to a Software as a Service (SaaS) offering they are discovering it takes longer than first expected and comes with many challenges.
Platform as a Service (PaaS) provides a great way to create highly scalable applications. PaaS accelerates application development, testing, deployment and maintenance of your SaaS application.
Join Mark Eisenberg, a thought leader in cloud and mobile, and Motifworks' Nitin Agarwal to learn how to accelerate your migration to SaaS using PaaS. This webinar will feature a review of the Windows Azure PaaS platform and Motifworks SaaS development framework to further reduce your time-to-market.
Attendees will learn:
* The benefits of Platform as a Service over Infrastructure as a Service (IaaS)
* How PaaS accelerates development and delivery of SaaS
* Azure Cloud Services (PaaS) overview
* Best practices for great cloud application on Azure PaaS
The Open SDN Stack
Apr 17 2014
44 mins
Rob Sherwood, CTO, Big Switch Networks
Rob Sherwood, CTO of Big Switch Networks, will present an end-to-end open source technology stack for SDN R&D, spanning switch hardware, software and SDN controllers. He will touch on the Open Compute Projects' switch design, Open Network Linux, Project Indigo, Project Floodlight and others. He will also discuss how these projects fit together, their various evolutionary paths, and how this stack fits in the landscape of emerging commercial and open source SDN products.
OpenStack Icehouse Release Update
Apr 17 2014
44 mins
Mark Collier, COO, OpenStack Foundation; Troy Toman, Cloud Architect, Rackspace; Das Kamhout, IT Principal Engineer, Intel
Join Mark Collier, COO of the OpenStack Foundation, Troy Toman, Cloud Architect at Rackspace and Das Kamhout, IT Principal Engineer at Intel, to discuss updates on Icehouse, the latest OpenStack software release, available on Thursday, April 17. OpenStack Icehouse is the ninth release of the open source software for building public, private, and hybrid clouds. Mark will also review the next OpenStack Summit agenda taking place in Atlanta, Georgia May 12-16, 2014 at the Georgia World Conference Center.
This webinar will cover:
- The latest features and trends from OpenStack Icehouse
- Updated growth metrics from the OpenStack community
- Opportunities to learn more at the OpenStack Summit in Atlanta May 12-16, 2014
SDN, NFV, and the Cloud Disruption: The Next Generation ODIN
Apr 17 2014
41 mins
Dr. Casimer DeCusatis, Distinguished Engineer, IBM Corporation
The IT industry is currently undergoing one of the most radical disruptions in its history, as traditional data centers are being replaced with cloud computing environments. New workloads such as mobile computing, social networking, and big data analytics are driving the need for a more dynamic, agile approach to enterprise computing. It is most prevalent in the networks within and between modern data centers.
This presentation will discuss a new approach to application-aware data networking based on open industry standards (the Open Datacenter Interoperable Network, ODIN). In particular, we focus on recent approaches to SDN and NFV which deliver real value in next generation data networks. We will also discuss case studies which demonstrate the value of emerging cloud based, software defined environments.
Make Your Storage Work for Your Big Data Project
Apr 16 2014
30 mins
Ben Woo, Managing Director, Neuralytix, Inc.
Big Data projects do not always require new storage. In fact, the best Big Data projects can leverage existing storage solutions. This presentation will look at how you can make your existing storage work for Big Data.
best practices for achieving enterprise IT efficiency
The Enterprise Architecture channel presents the next generation of enterprise IT: recognizing the strategic importance of the data center to make companies more nimble and competitive. These presentations will help demanding IT professionals achieve flexibility, scalability and performance with reduced risk and complexity.
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Title: Protect Apps, Not Just Data: Enterprise-class BC/DR in a Virtual Environment
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Jun 13 2012 7:00 pm
Presented by: Dave Simpson, Analyst, The 451 Group; Mark Montagna, The Philadelphia Contributionship; Gil Levonai, VP of Products, Zerto
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