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Relationship Between Endothelial Function and Fibrinolysis in Early Hypertension
Abnormalities in fibrinolysis, endothelial function, and glucose and lipid metabolism have been reported in hypertension. This study was conducted to examine the interrelationships between fibrinolytic factors, glucose and lipid metabolism, and endothelial function in hypertension. The effects of administering an angiotensin converting enzyme inhibitor, benazepril, were also examined. Blood levels of the following substances were measured in patients with borderline and mild hypertension (n=50, 51±19 years) and in age-matched controls (n=10): total cholesterol, triglycerides, tissue plasminogen activator activity and antigen, and plasminogen activator inhibitor type 1 activity and antigen. Insulin sensitivity was assessed by oral glucose tolerance test, and endothelial function was assessed by evaluating changes in diameter of the brachial artery during reactive hyperemia as observed by ultrasonography. Activities of tissue plasminogen activator and plasminogen activator inhibitor type 1 were both elevated in the hypertensive patients. Stepwise multiple regression analysis showed that plasminogen activator inhibitor type 1 antigen correlated with insulin sensitivity, total cholesterol levels, and triglycerides levels (P<.01). Endothelial function was negatively correlated with tissue plasminogen activator activity and antigen (P<.01). The chronic administration of benazepril (5–10 mg/d) for 20 weeks improved insulin sensitivity, endothelial function (6.6+3.4→9.0+2.5%, P<.01), and tissue plasminogen activator activity and antigen. These results indicate that abnormalities in fibrinolysis are associated with endothelial dysfunction as well as disorders of glucose and lipid metabolism in patients with borderline and mild hypertension. The treatment of such patients with benazepril appeared to improve the impairment in fibrinolysis and endothelial dysfunction.
- fibrinolysis
- endothelium
- hypertension
- insulin resistance
- tissue plasminogen activator
- plasminogen activator inhibitor type 1
- angiotensin converting enzyme inhibitor
- ACE = Angiotensin converting enzyme
- FDP = fibrinogen/fibrin degradation products
- PAI-1 act = plasminogen activator inhibitor type 1 activity
- PAI-1 ang = plasminogen activator inhibitor type 1 antigen
- PAI-1/tPA = ratio of tPA ang to PAI-1 ang
- Σ BS = sigma plasma glucose
- Σ INS = sigma plasma insulin
- tPA act = tissue plasminogen activator activity
- tPA ang = tissue plasminogen activator antigen
An impairment of fibrinolysis is an established risk factor for such thrombotic events as stroke or myocardial infarction.1–3⇓⇓ Thrombosis and fibrinolysis are interrelated in the development of atherosclerosis.4 Thus, the evaluation of fibrinolysis in the pathophysiology of cardiovascular diseases is essential. In hypertension, a close relationship has been demonstrated between disorders of glucose and lipid metabolism and disturbances of fibrinolysis.5,6⇓ Fibrinolytic activity is primarily determined by the balance between the levels of tissue plasminogen activator (tPA) and plasminogen activator inhibitor type 1 (PAI-1), both of which are synthesized in the vascular endothelium,7,8⇓ and vascular endothelial injury induces an imbalance in fibrinolysis.4,7,8⇓⇓ Because hypertension and disorders of glucose and lipid metabolism are accompanied by endothelial dysfunction,9 the relationship between endothelial function and fibrinolytic balance needs to be examined in detail and more precisely. However, the relationship between endothelial dysfunction and fibrinolytic imbalance has not yet been thoroughly investigated in the clinical setting.
Some antihypertensive drugs exhibit a beneficial effect on impaired fibrinolysis.10,11⇓ Angiotensin converting enzyme (ACE) inhibitors are reported to have such effects on fibrinolysis,11 as well as on glucose metabolism12,13⇓ and endothelial function.14,15⇓ However, the interactions between the changes in fibrinolysis, glucose metabolism, and endothelial function following treatment with an ACE inhibitor have not been studied.
Recently, a noninvasive means for the clinical evaluation of vascular endothelial function has become available through high resolution ultrasonography.16,17⇓ The present study examined the interrelationships between endothelial function as determined by ultrasonography, fibrinolysis, and glucose and lipid metabolism in patients with borderline or mild hypertension. The effects of long-term treatment with an ACE inhibitor on these epiphenomena were also examined.
We selected consecutively for the present study 50 ambulatory Japanese patients with borderline-to-mild hypertension (24 male, 26 female; mean age, 51±9 years) who visited Teikyo University School of Medicine, Ichihara Hospital, from April 1996 to February 1997. Inclusion criteria were as follows: the subjects had no history of receiving antihypertensive medications; had acceptable ultrasonographic recordings of the heart, carotid artery, and brachial artery; and had average blood pressure levels in systole between 140 and 180 mm Hg, and in diastole between 90 and 105 mm Hg over three consecutive visits prior to the study. Patients with secondary hypertension or other serious medical problem that required specific treatment were excluded from the study. As control subjects, age-matched healthy volunteers (6 males and 4 females; mean age, 46±6 years) were recruited for the determination of brachial endothelial function and its reproducibility, fibrinolytic parameters, and ultra-sonographic examinations of the heart and carotid artery.
Study Protocol
Informed consent was obtained from all subjects based on a protocol approved by the Ethics Committee of Teikyo University School of Medicine, Ichihara Hospital. Each patient underwent echocardiography, ultrasonographic examination of the carotid artery, study of brachial endothelial function, oral glucose tolerance testing, and routine laboratory examinations of serum and urine obtained in the fasting state. Patients with mean systolic pressure of <160 mm Hg and diastolic pressure <96 mm Hg during three consecutive visits had educational counseling on modification of lifestyle, and were scheduled to be followed-up without antihypertensive medication at 3-month intervals. Patients with a mean systolic pressure ≥160 mm Hg and/or diastolic pressure ≥96 mm Hg were prescribed an ACE inhibitor, benazepril (5 mg/d) (Novartis) and were followed at the outpatient clinic. If the medication had not reduced systolic pressure to <150 mm Hg and diastolic pressure to <90 mm Hg after 2 weeks of treatment, the dose was doubled. If the systolic pressure remained ≥150 mm Hg or diastolic pressures remained ≥90 mm Hg after 5 weeks of the treatment, amlodipine (5 mg/d) was added to the regimen. If systolic pressure remained ≥150 mm Hg or diastolic pressure remained ≥90 mm Hg at the beginning of the 10th week, the subject was excluded from the study. Thereafter, patients were followed at 4-week intervals at the outpatient clinic. After the systolic pressure had remained below 150 mm Hg and diastolic pressure had remained below 90 mm Hg for 20 weeks, we again performed echocardiography, ultrasonographic examination of the carotid artery, a study of brachial endothelial function, oral glucose tolerance testing, and routine examinations of serum and urine obtained in the fasting state, except for the oral administration of the antihypertensive medication.
Blood Pressure Measurements
Blood pressure was measured in an office setting by the conventional cuff method with a mercury manometer. Patients remained seated for at least 10 minutes before blood pressure measured. Diastolic pressure was determined at the 5th Korotkoff sound.
Ultrasonographic Examinations of the Heart and of the Carotid Artery
The ultrasonographic examinations were performed by the same well-trained sonographer (Y.K.). With the patients in the left semilateral decubitus position, M-mode echocardiograms guided by two-dimensional echocardiography were obtained by a Sonolayer (SSH-160A, Toshiba Co) with a 2.5-MHz or a 3.75-MHz transducer. Data were printed on a split-chart recorder at a recording speed of 50 mm/s. End-diastolic interventricular septal thickness, left ventricular internal diameter, and posterior wall thickness in diastole were measured according to the method based on recommendations of The American Society of Echocardiography and Penn Convention.18 Each dimension was defined as the mean of two M-mode measurements obtained by two different investigators (H.T. and Y.K.). Left ventricular mass was calculated by Devereux's method.19 The left ventricular mass index was derived from left ventricular mass devided by the body surface area.
After the completion of echocardiographic examination, the patients was placed in the supine position with the neck slightly extended, and the common carotid artery, carotid sinus, and extracranial internal and external carotid arteries were examined (long-axis and short-axis views) with an ultrasonographic system (SSH-160A, Toshiba Co) equipped with a 7.5-MHz transducer. The common carotid artery was examined in a two-dimensional, long-axis view approximately 1 cm upstream from the carotid bifurcation. Thereafter, the transducer was rotated 90° and M-mode tracings of this area of the common carotid artery were obtained in a two-dimensional short-axis view along with simultaneous electrocardiographic recordings on a split-chart recorder (recording speed of 50 mm/s). The presence of an atherosclerotic plaque was defined as a 50% thickening of the wall relative to the surrounding wall. If plaque was observed in a searching area, the transducer was moved to upstream in the common carotid artery. End-diastolic far-wall thickness and end-diastolic and peak systolic internal dimensions were measured using a mean of M-mode images obtained from the right and the left common carotid artery for consecutive three cardiac cycles.
All of the measurements of ultrasonographic examinations used were a mean of two readers (H.T. and Y.K.). The reproducibility of the echocardiogram and the ultrasonographic measurements of the carotid artery in our institute has been previously reported elsewhere.20
Brachial Endothelial Function Test
The brachial endothelial function test, a modified version of Celermajer's method16 was performed in the morning fasting state by a well-trained cardiologist (H.T.). Images of the brachial artery of the dominant arm in each subject were obtained with an ultrasonographic system (SSH-160A, Toshiba Co) equipped with a 7.5-MHz transducer. A long-axis view of the straight segment (at least 1 cm) of the brachial artery was obtained immediately above the antecubital fossa. This straight segment was placed at the center of the long-axis image and the diameter of the brachial artery was determined. The center of that image was marked by placing a piece of tape on the skin of the antecubital fossa, and the transducer was rotated 90°. The diameter of the brachial artery in the short-axis view was re-confirmed. Next, M-mode tracings of this area of the brachial artery were obtained in a two-dimensional short axis view together with simultaneous electrocardiographic recordings on a split-chart. After the basal recordings of brachial artery were obtained, reactive hyperemia was produced by inflating the cuff on the upper arm to 20 mm Hg above systolic blood pressure for 3 minutes. Thirty seconds after the release of the cuff, M-mode tracings of the same area of the brachial artery were obtained. Ten minutes after the release of the cuff, a glyceryl trinitrate spray (0.4 mg) was administered sublingually, and, 90 seconds later, M-mode tracings were obtained of the same area of the brachial artery. The diameter of the brachial artery was determined at the end of the T wave using the mean of M-mode images over three consecutive cardiac cycles. The percentage of changes in diameter of the brachial artery in response to reactive hyperemia or to the administration of glyceryl trinitrate were calculated.
The internal diameter of each brachial artery was measured by two observers (H.T. and Y.K.). Interobserver and intraobserver variability in repeated measurements of identical recordings and in the reproducibility of hyperemia and in the response to glyceryl trinitrate were assessed by an independent study of 10 healthy volunteers and another 6 patients with ischemic heart disease (4 males and 2 females; mean age, 56±9 years). Interobserver and intraobserver variability for repeated measurements of same recordings were 0.040±0.05 mm and 0.020±0.03 mm, respectively. To assess the reproducibility of the hyperemia and the response to glyceryl trinitrate administration, the brachial endothelial function test was performed in healthy volunteers on two occasions at least 2 weeks apart. The mean differences in the percentage of changes in diameter of the brachial artery in response to hyperemia and glyceryl trinitrate administration were 1.3±1.3% and 1.5±1.8%, respectively.
Oral Glucose Tolerance Test
The oral glucose test was performed in the morning after a 12-hour overnight fast. Blood samples were drawn before ingestion and 30 minutes, 60 minutes, and 120 minutes after ingestion of a solution containing 75 g of glucose. Total area under curve of the plasma glucose-time plot (sigma plasma glucose or Σ BS) or insulin-time plot (sigma plasma insulin or Σ INS) were calculated. Insulin sensitivity was defined as sigma plasma glucose/sigma plasma insulin.
Laboratory measurements
Measurements of fibrinolytic and hemostatic variables and lipids were performed on the day of the oral glucose tolerance test on blood samples obtained before the ingestion of glucose (8:30 am). Blood samples for determination of fasting lipid levels were collected into tubes containing EDTA. Plasma triglycerides, total cholesterol and high-density lipoprotein cholesterol levels were measured enzymatically with a Hitachi 731 Analyzer. Blood samples for determination of fibrinolytic parameters were collected with citrate buffer (pH 4.5). The tPA and PAI-1 activities were assessed with a chromogenic assay kit (Spectrolyse tPA/PAI-1 activity assay kit, American Diagnostica). Plasma tPA and PAI-1 antigen levels were measured by enzyme-linked immunosorbent assay (Imulize tPA kit, Biopool AB, PAI-1 ELISA kit, Monozyme). Plasma fibrinogen levels were determined with a one-stage clotting assay kit (Thrombocheck Fib, International Reagents Corp). D-dimer was measured by an enzyme-linked immunosorbent assay (D-Di test, Boehringer Mannheim). Fibrinogen/fibrin degradation products (FDP) was determined by a latex photometric immunoassay method (COBAS MIRA).
Statistical Analysis
Data are expressed as the mean±SD. Statistical analysis was performed using software from SPSS Inc. The significance of differences between the hypertensive patients and control subjects was evaluated by the Student's unpaired t-test. The paired t-test was employed to evaluate changes subsequent to ACE inhibitor treatment. Linear regression analysis was used to evaluate the inter-correlations among the fibrinolytic and hemostatic parameters and other parameters. Thereafter, stepwise multiple regression analysis was performed on the fibrinolytic and hemostatic parameters and other parameters to identify significant correlations as determined by the linear regression analysis. A level of P<.05 was accepted as statistically significant.
Of the initial 50 patients, 20 patients exhibited borderline hypertension, and 30 patients had mild hypertension on whom initial treatment with benazepril was instituted. Of these 30 patients, 17 patients continued to receive benazepril alone, 6 received benazepril plus amlodipine, and 7 patients were excluded from further study because of cough (n=4), poor control of blood pressure (n=1), or a personal reason (n=2). In addition to the expected differences in blood pressure, left ventricular mass index, tPA activity and antigen, and PAI-1 activity and antigen were higher in the hypertensives than in controls (Table 1). The changes in brachial artery diameter in response to reactive hyperemia and glyceryl trinitrate administration were smaller in the hypertensive patients than in the controls.
Cross-correlations between fibrinolytic and hemostatic parameters and other targeted parameters are presented in Table 2. Linear regression analysis revealed a significant negative correlation between tPA activity and the change in brachial artery diameter in response to either reactive hyperemia or glyceryl trinitrate, while tPA antigen levels revealed a positive correlation with triglycerides levels and a negative correlation with the change of brachial artery diameter in response either to reactive hyperemia (Fig 1) or glyceryl trinitrate. There was a positive correlation between PAI-1 activity and triglycerides levels. In addition, PAI-1 antigen levels displayed correlations with total cholesterol levels, triglycerides levels, Σ INS, and insulin sensitivity. Lastly, fibrinogen correlated significantly with age. The results of stepwise multiple regression analysis (Table 3) revealed several equation variables for these parameters. In addition, by linear regression analysis, the change of brachial artery diameter in response to reactive hyperemia had a negative correlation with sigma plasma glucose (r=−0.29, P<.05), but not with plasma triglycerides, total cholesterol, or high-density lipoprotein cholesterol levels. After the treatment with benazepril alone or benazepril plus amlodipine for 20 weeks, blood pressure and the left ventricular mass index decreased significantly (Table 4). tPA antigen and activity, PAI-1 activity, sigma plasma glucose, insulin sensitivity, and the change in brachial artery diameter in response to reactive hyperemia improved significantly either in patients treated with benazepril alone or benazepril plus amlodipine.
Numerous pathophysiological factors are associated with hypertension,21 and some of these factors, such as the increase in shear stress caused by elevated blood pressure,22 disorders of glucose and lipid metabolism,5,6⇓ atherosclerosis,23 and endothelial cell injury,24 are associated with imparied fibrinolysis. However, previous studies evaluating abnormal fibrinolysis in hypertension have focused only on disorders of glucose and lipid metabolism.5,6⇓ The present study evaluated the relationships between the severity of hypertension, disorders of glucose and lipid metabolism, the severity of atherosclerosis, and the extent of vascular endothelial dysfunction. Although the severity of hypertension was evaluated by both blood pressure values and left ventricular mass index, and the severity of atherosclerosis was evaluated by the intimal-media thickness of the carotid artery, these indices did not correlate with the severity of abnormalities of fibrinolysis. However, parameters of glucose and lipid metabolism were correlated with PAI-1 activity or its antigen levels, while endothelial function was negatively correlated with tPA activity and antigen levels. Thus, abnormalities in fibrinolysis in patients with borderline and mild hypertension are closely associated with disorders of glucose and lipid metabolism and endothelial dysfunction, rather than with the severity of the hypertension or atherosclerosis. Therefore, the results of the present study particularly suggest that PAI-1 activity and antigen levels are affected by disorders of glucose and lipid metabolism, and that tPA activity and antigen levels are affected by endothelial dysfunction. Furthermore, the fact that endothelial function demonstrated only a partial correlation with Σ BS suggests that endothelial function directly affects the fibrinolytic balance.
While normal vascular endothelium is in a nonthrombotic state, disruption of the vascular endothelium results in the synthesis and release of procoagulant and anticoagulant substances from the disrupted vascular endothelium.4,7⇓ Some studies suggest that an increase in tPA antigen level indicates endothelial dysfunction.3,25⇓ The present results are consistent with this hypothesis and confirm that increases in tPA activity and antigen levels reflect endothelial dysfunction in patients with borderline and mild hypertension. The fact that ultrasound examination of the carotid artery in our study did not detect regions of advanced plaque indicates that atherosclerosis was not marked in the present subjects. Although a downregulation of tPA production has been observed in plaque lesions of the aorta,24 the present results suggest that tPA synthesis in the endothelium is activated in the early stages of atherosclerosis.
Beneficial effects of ACE inhibitors on insulin resistance12,13⇓ and impaired fibrinolysis11,26⇓ have been reported, and some studies have indicated that such drugs may improve vascular endothelial function.14,15⇓ Clinically, endothelial function is usually assessed by the blood flow response to acetylcholine or the development of reactive hyperemia.27,28⇓ Both methods induce vasodilation, the former being mediated primarily by nitric oxide and the latter by nitric oxide plus vasoactive substances such as prostaglandins, adenosine, and potassium.29 Some studies have indicated that ACE inhibitors do not affect endothelial function as evaluated by the response to acetylcholine.27,30⇓ However, consistent with the results of the present study, Iwatsubo et al reported that an ACE inhibitor does improve endothelial function as evaluated by the response to reactive hyperemia.15
Angiotensin II increases the synthesis of PAI-1 in the vascular endothelium, and the reduction of angiotensin II levels by an ACE inhibitor improves fibrinolytic balance.31 In addition, insulin also increases PAI-1 synthesis,32 and the improvement in glucose metabolism following treatment with benazepril may have beneficial effects on fibrinolysis. In the present study, benazepril reduced the activity of both tPA and PAI-1 and tPA antigen without altering the ratio of levels of tPA antigen to PAI-1 antigen, thought to be a better index of overall fibrinolytic potential.11,31⇓ Benazepril did not affect plasma levels of FDP or D-dimer. These data suggest that the improvement of endothelial function following benazepril treatment may have a favorable effect on the prevention of thrombogenesis. The results also indicate that assessment of the endothelial function should be considered in the management of patients with hypertension.
The present study demonstrated beneficial effects of benazepril on fibrinolytic abnormalities and endothelial function. However, the numbers of patients were too small to examine whether the coadministration of amlodipine alter those beneficial effects of benazepril. Various vasoactive substances that are synthesized in the vascular endothelium affect hemostasis and fibrinolysis.4,7,8⇓⇓ Further study is necessary to identify the factors that contribute to the abnormal fibrinolysis observed in patients with hypertension. The results of the present study indicate that the fibrinolytic imbalance and endothelial dysfunction are reversible in patients in the early stages of hypertension. The relationship between the fibrinolytic imbalance and endothelial dysfunction and the reversibility of such abnormalities should be examined in patients in the advanced stages of hypertension.
In conclusion, the present study showed that abnormalities in fibrinolysis were associated with disorders of glucose and lipid metabolism, as well as with endothelial dysfunction in patients with borderline or mild hypertension. The treatment of hypertensive patients with an ACE inhibitor appeared to be effective against these abnormalities.
- Received September 16, 1997.
- Revision received October 16, 1997.
- Accepted October 29, 1997.
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- Relationship Between Endothelial Function and Fibrinolysis in Early HypertensionHirofumi Tomiyama, Yutaka Kimura, Hiroyuki Mitsuhashi, Takashi Kinouchi, Hideo Yoshida, Toshio Kushiro and Nobutaka DobaHypertension. 1998;31:321-327, originally published January 1, 1998https://doi.org/10.1161/01.HYP.31.1.321
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- Relationship Between Endothelial Function and Fibrinolysis in Early HypertensionHirofumi Tomiyama, Yutaka Kimura, Hiroyuki Mitsuhashi, Takashi Kinouchi, Hideo Yoshida, Toshio Kushiro and Nobutaka DobaHypertension. 1998;31:321-327, originally published January 1, 1998https://doi.org/10.1161/01.HYP.31.1.321Permalink:


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Celebrate Eid with Exciting Dining Options at Emirates Golf Club and Dubai Creek Golf & Yacht Club
Special Eid brunch packages on offer
5thAugust 2012, UAE; The Emirates Golf Club and Dubai Creek Golf & Yacht Club will be celebrating Eid al Fitr by offering exclusive gourmet brunch packages at Legends, M's and in the QD's tent.
The brunches take place every day during Eid and will feature a range of international and Arabic dishes. Legends will have its full brunch menu with the addition of local favourites such as lamb ouzi and hot and cold mezzeh. M's and QD's will be serving up a wide selection of traditional dishes including; shish taouk, kofta, biryani, um-ali, konafa and barbusa.
Packages at M's at the Emirates Golf Club are AED 125 per adult and AED 60 per child and the two Dubai Creek Golf & Yacht Club venues, Legends and the QD's Tent are AED 205 and AED 125 per person, children below 12 eat for free and all packages are inclusive of soft drinks.
Available from 12 noon to 3:30pm the Eid packages are ideal for groups and families with Legends and M's offering a special area with entertainment for kids throughout the day. For reservations at M's call +971 4 417 9999 or email email@example.com and for Legends and QD's call +971 4 295 6000 or email email@example.com.
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Dubai Golf also manages an online tee time booking system for its three golf courses, the Majlis, Faldo and Dubai Creek Course, as well as servicing a central reservations office that allows guests to make golf reservations at courses throughout the United Arab Emirates.
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Emirates Golf Club, host of the European Tour Omega Dubai Desert Classic and Omega Dubai Ladies Masters, was the first all grass championship golf course in the Middle East when it opened in 1988. Taking pride in its 36 holes of world-class golf, the club sports two of the city's finest must-play courses, the Majlis and the Faldo Course, which is also the only 18 hole course in the region to offer night golf. Both courses combine the natural rolling desert terrain for a serious golfing test, while the signature clubhouse, remains the most eye-catching in the region. The Majlis Course has been presented with numerous accolades over its 23 year history, the most recent of which were its 2011 ranking by Golf World magazine as one of the 'Top 100 Golf Courses in the World' and its award for 'Best Course Middle East' in the Asian Golf Monthly Awards 2010 .
About Dubai Creek Golf and Yacht Club
Dubai Creek Golf & Yacht Club is the premier golf resort in the Middle East located in the heart of Dubai. The resort incorporates an 18 hole championship golf course, voted one of the world's 'Top 100 Must-Play Golf Courses', a 9 hole Par 3 course, golf academy, six restaurants and bars, gymnasium, tropical swimming pool, the 225-bedroom Park Hyatt Dubai, 92 residential executive villas and a 121-berth marina.

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The Wingscapes BirdCam Pro Digital Wildlife Camera is a motion-activated, digital photographic equipment that offers a closer view of our surprising natural world. It features a powerful 8.0 megapixels and an alterable flash for night time photos and videos. It is equipped with a timelapse setup menu for recording subjects like plants or weather, and a two inch colored preview screen that will let you view the images right away. The advanced Setup menu introduces a user-friendly photo and video program that will let you select time / date / location imprint, number of images per event, delay, program resolution, sensitivity of sensor, delete images and diagnostic test.
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Product Documents
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Thanks effie
I am Celebrex200 miligrams twice a day now and use pain paatches like icy hot nad like yu I can also tell the weather. had a bone density scan more bobe loss in my hip regions r than in my spine region and was told my wrists will alway ache for the way they were severly broke. I will try the camphor oil for now I use icy hot or DMSO. haveyuo've heard of theragestric (sp) I have heard that is good too. I do wear wrist splints in cold weather and gloves too.
I sure do hope yur other moderator is ok.
If you are talking about the Theragesic Patches that warm as you wear them, I have used them. They helped me a lot. I used them for back pain, but they do make the different sizes for different areas of the body. It is like having a heating pad on, that you can go everywhere with. I think they are quite costly, but hey, they help.


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Cooper turns screenwriter for sci-fi project
The Hangover star is a big fan of Dan Simmons' Hyperion novels, about a space war, which are set to be made into a movie after producer Graham King acquired the rights for Warner Bros.
Cooper teamed up with a friend to write a screenplay for the film and they pitched their script to King, and the actor is convinced their ideas would make "an epic movie" – which he would love to direct.
He tells U.S. interviewer Charlie Rose, "There's this series of science-fiction novels called Hyperion by Dan Simmons… My friend and I went to Graham King, who owns the rights to Hyperion, and we wrote a treatment on spec saying, 'Look we know this is very audacious, but could you just read this spec we wrote? We think we have a way in to tell this story'.
"So now we're negotiating and… who knows what's going to happen? Ideally I'd love to direct it (but) there's no way! I shouldn't say that, you never know. This is a huge movie, this would be an epic movie. But at least we've taken the reins and said, we're going to go after it and now we're gonna write the script. At least we have a shot to write the script for Hyperion."
Cooper also reveals he plans to eventually step behind the camera and focus on directing: "Ultimately I would love to direct – that's ultimately what I wanna do."


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SUPER Summer
SUPER Summer is a summer camp program. SUPER Summer Threes is for children turning 3 years old by September 1st. Super Summer Fours/Fives is for children turning 4 or 5 years old by September 1st. Children must be toilet trained.
Camp runs from 8:45-11:15 a.m. The Threes class meets on Mondays/Wednesdays and the Fours/Fives class meets on Tuesday/Thursdays.
We will rotate through stations during the camp. The stations are: crafts, group games, free play outdoors, snack/story/music. Each session will also have a water play day. Sessions run for 2 weeks. You can sign up for 1, 2, or 3 sessions.
Summer 2017 – Session Dates & Fees
1) June 5-15 Beach Bonanza $90.00
2) June 20-30 Camping Adventures $90.00
3) July 5-July 13 Pirates Life For Me $70.00 (no class July 3 or 4)
In House Registration for Grace Church Members, current Growing With Grace Preschool students, and alumni begins on April 3rd.
Open registration begins on April 10th.
We will be filling openings on a first come, first serve basis. If a class becomes full, we will begin a waiting list.
Please direct any questions to: firstname.lastname@example.com or call 847/254-5820.


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- Please select a date to see the proper prices!
Description of the Accommodation
Rooms, services When taking a trip to Grantsville, booking a room at The Casselman Inn Grantsville may be a great decision. The hotel is offering 45 comfortable rooms to guests looking for accommodation in Grantsville. If you wish to learn more about the exact scope of services provided by The Casselman Inn Grantsville (including those available for an extra fee) or about the equipment of the rooms, you can find the complete list on the information sheet below.
Payment Advance bank card payment or credit card guarantee may be required for the reservation, depending on the chosen date, room and price.
Arrival, opening hours The earliest check-in time is 15:00, the latest check-out time is 11:00. The personnel of the hotel can speak with you in English.
The Casselman Inn Grantsville rooms Rooms
- Please select a date to see the proper prices!
Accommodation services
Hairdryer, Microwave oven


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We'll be in Greenwich village for a wedding this weekend (coming from Boston), and we'll have two meals on our own. Friday night and saturday night. Were hoping to go to Babbo, but I guess I should have called much earlier -- they are all booked. Any suggestions for good places to go (where I can still get a reservation)?
Here is what we are looking for:
Price: up to $50/person for food (without wine, tax, tip).
Cuisine: Italian, French, New American, Mediterranean, or really good, interesting bar food (where we can have several appetizers as a meal).
We are not big on atmosphere or food esthetics (we don't mind them, but we don't seek them out either). But we are obsessive about the food (seasoning, doneness, choice of ingredients, etc).
Something in Greenwich village would be great, but we'll travel for great food.
Thanks so much for your help!


text: 19 Jul BAMTV: Ben Bruce and Cameron Liddell BAM Magazine2014-07-19T21:09:29+00:00 By BAM Magazine https://www.youtube.com/watch?v=lnO-8gPQwbQ&list=UUSEG-G3FUUwE7qJuscvhX2Q Share this post FacebookTwitterLinkedInGoogle +Email Author BAM Magazine BAM Magazine began publication in 1976 on the premise that a free music magazine would attract readers if given away at record shops, musical instrument stores and concerts. Six months later, it paid off. BAM was the fastest growing publication in the United States. BAM focused on the California music scene, and produced the highly recognized Bay Area Music Awards (The BAMMIES) for over 25 years!


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Hokulea's voyage around the world is temporarily on hold Sunday because of Hurricane Matthew.
Hawaii's voyaging canoe just went up and down 61 locks through the waterways of canada and the northeastern U.S., and although she was due to return to New York City Sunday night.
She instead will remain in the safest place they can find, which is in place, 37 miles north of New York City on the Hudson River away from storm surges and strong currents caused by a storm.
"We're taking her up and hiding her in a marina up in the Hudson the farther north you are and the more west you are, with this particular storm the better," said Polynesian Voyaging Society president Nainoa Thompson by phone. "We'll probably be there until another eight days until the storm goes by, we're not going to move Hokulea until the storm passes and goes north of New York."
The crew is taking down the sails and rig and will set anchor depending on direction and strength of the wind.
Once they know they're in the clear, Hokulea will continue south until Virginia where she'll be taken out of the water and go into drydock for a month, then hurricane season will be over and she can be ready to reach the Panama Canal.


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|Posti letto
|Camere da letto
|92 m²
|Tipo di proprietà
|Soggiorno minimo
|7 Notti
Confortevole, appartamento indipendente di Villa La Torre è l'unica in grado di essere affittato con due camere doppie, o UNA CAMERA MATRIMONIALE per un prezzo ridotto. Non sarete tenuti a condividere l'appartamento con chiunque altro. Nuovi elettrodomestici moderni in tutto - tra cui il lavaggio completo, riciclaggio, angolo cottura, lavastoviglie e frigorifero / congelatore. Francese porte conducono sulla esclusivo uso gelsomino coperta patio e la piscina si trova nelle vicinanze. Tutto pronto in sicurezza di due acri splendidi giardini privati. Bella Umbria è il cuore verde d'Italia e ha il 4 ° lago più grande del paese.
ATTIVITA & DIVERTISSEMENTS LOCALI: Oltre a molti Jazz umbro perenne, Blues e festival di musica classica e mostre a livello locale, Seguito di Villa La Torre è convenientemente posizionato per tali attività e divertissement come raccolta olive, vendemmia, il vino e degustazione, corsi di cucina, la natura vagante, natura e gite di istruzione, itinerari enogastronomici, itinerari storici, trekking, corsi di ceramica, escursioni sci di fondo, equitazione, istruzione equitazione, passeggiate, bird watching, golf, tiro con l'arco, paracadutismo, tiro, ciclismo, mountain bike, i traghetti sul lago, corsi di pesca, pedalò, barche a remi, spiaggia per prendere il sole, canoa e nuoto, vela, windsurf, pesca grossa. www. placeinumbria. com
This is a wonderful place to stay. The apartment is extremely well furnished, and all needs are catered for. Clive and his family were very welcoming and were always on hand to offer advice. We spent a magical day, thanks to them on the lake, sailing and swimming and nothing was too much trouble.
The area is enchanting full of historic walled towns, wild flowers, birds and animals, with easy access to wonderful places such as Assisi and Sienna.
One of our favourite places to visit was Panicale, a few miles up the road, where we had a number of idyllic lunches in its lovely square.
This was our first family holiday to Italy and we were certainly not disappointed and would highly recommend this as a place to stay.
I was part of a film crew which took over Villa La Torre's Primo house and Seguito apartment for a month, while sourcing locations for a new US movie set in 15th-century Italy.
I've been in this business 32 years, and have to say this was easily the most beautiful, emotive and spectacular countryside I've witnessed.
Our director (can't say his name but you'll know him!) is a regular visitor to Seguito; he chose the venue especially and the owners didn't let us down.
The renovated house and villa are kept in immaculate condition. Comfortable, fully equipped, and there's a relaxing sense of home in every room. I loved every minute of our stay.
I went with four friends on a coarse-fishing expedition on Lake Trasimeno. We stayed 21 nights at Villa La Torre's "Seguito" apartment. It's a marvellous secluded holiday home, all mod cons, plenty of storage space for our gear, so convenient for the lake and buying in supplies from Panicale and Panicarola.
Decent English guy in charge of the property always on hand when needed - very well up on local sights and amenities, good advice, helped with language, even knew best fishing pegs!
- Talking of which, we netted 15lb pike and v-v big perch daily.
Days out to Perugia, Florence (Firenze) and Assisi - stunning! - Nearly as good as the fishing!
The website for Villa La Torre's apartment describes this area as magical. We spent four weeks there (extended our intended stay by 10 days!) and have to agree. There's an atmosphere, a feeling, an ambience which we've never experienced anywhere else: to quote the website again - "carefree calm and dreamy peace".
We went with younger friends who went missing for most of every day, saling, cycling and fishing on the big beautiful lake which is just a stone's throw from the apartment door.
The apartment? Comfortable, everything we needed readily available, easy to use. Nice bedrooms. The place has been converted with obvious painstaking care; and the attention we received on arrival and throughout made us feel like VIPs.
Unexpected bonus - the air here is so unpolluted; it's all agriculture and horticulture. There's a delicious quietude. We've never slept so deeply and reinvigoratingly in our lives! - A wonderful place to recharge the batteries.
Battery rechargeable
This was the perfect holiday home for us - two adults; two children (4 and 14). Everything in the "Villa La Torre Seguito" apartment is convenient, impeccably clean, and sensibly thought through.
The large, secure and secluded gardens were just the thing for our older child, while great progress was mad with the younger one's swimming lessons - the private pool was perfect for his confidence.
The surrounding countryside is ... well, no adjectives can describe the sheer visual beauty and spiritual calm we derived from just a simple walk along the utterly gorgeous lake.
One of the property owners was never more than minutes away if we needed help, advice and information. Both before and after, he and Chris couldn't do enough for us.
Whilst the motif of our own holiday was quiet, calm, privacy and relaxation, the opportunity for excitement and adventure - sailing, cycling, horse-riding, and sightseeing in Perugia and Florence - lay just minutes away.
We're so happy to be able to recommend this venue wholeheartedly to anyone who enjoys architecture, history, the peace of unbesmirched nature, great food - and fine wine.
Situato nella magica tranquillità d'Italia Cuore Verde, Villa La Torre si trova vicino a un lago possente, circondato da vigneti, frutteti e oliveti, e circondato da borghi medievali e antichi monasteri. Città nei dintorni storici comprendono Assisi, Perugia, Siena e Firenze. L'area è dedicata alla agricoltura, orticoltura, la storia, il cibo, il vino e la natura. Inoltre ci sono molti concerti musicali e spettacoli nella zona. Pur offrendo isolamento totale e privacy, Villa La Torre si trova vicino a molte attività Lake orientate come la vela, la pesca e l'equitazione. Ci sono anche infinite possibilità di divertimento, scoperta e avventura in antico e moderno Umbria, a pochi minuti di distanza sulla splendida rete stradale e ferroviaria italiana.
Altre attività: C'è una serie di visite guidate, localizzate exhibitons e festival - storici, natura, artigianato, prodotti alimentari e bevande, religioso, musicale
|Tariffa minima
|Notti aggiuntive
|Per notte weekend
|Per settimana
|Al mese
7 notti soggiorno minimo
per 7 notti
|Non ci sono spese aggiuntive obbligatorie


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Is it me or is the product demo making a comeback in television advertising? They've come a long way since the 'classic' product demonstrations utilized back in the 1970's and 80's, and seem to be all around at the moment. Thanks to a bit of creative and innovative thinking, today's modern versions are quite engaging and effective.
Back in the day, product demos were utilized in a fairly generic manner and many were often portrayed in sterile and 'scientific' environments. Think back to Bounty's "quicker, picker-upper" demos that often cut to a laboratory-like setting. I'm not implying such demos are ineffective — just a little boring, perhaps.
Here's an example of a 'traditional' but very effective demo that I worked on back in the 1990's at Grey Advertising. Why was it so impactful? Because it combined a relevant insight (that consumers were mistreating their gas pain with antacids) with a powerful product demonstration that communicated efficacy in a compelling and believable way. Phazyme was a distant #3 in the anti-gas category until this campaign broke; eventually hitting #1 brand status for a period of time after steady support.
Today's demos have evolved and may look a bit different, but they are still quite effective at 'validating' efficacy or communicating a key benefit. In addition, some brands use the device simply to activate an insight or encourage their target consumer to take action. Below are four examples that recently caught my eye and engaged my curiosity.
Prudential: How do you grab people's attention in the cluttered retirement planning market that constantly bombards with a "start to save now" message? You take a fairly ordinary piece of data and bring it to life in a visually engaging way. Did you know that the brain works much more efficiently when it can visualize information?
Febreze: How do you get people to believe a room deodorizer actually works to cover up the toughest odors? Shock them into thinking, "Could that really be true?"
Ally Bank: How do you get anyone to believe anything a bank promises? You surprise them by doing (and saying) the completely unexpected. "If your bank takes more money than a stranger, you need an Ally." Hard to oppose that proposition!
Toyota Tundra: Domestic pick-up trucks are born from American blue-collar toughness. So how does Toyota demonstrate it belongs in the same league? By a brute, physical display of strength: it tows a national symbol of American exploration and adventure. (Be sure to listen 45 seconds in for the crowd shouting, "USA" subtly in background.)
Such examples suggest product demos can serve a role greater than communicating efficacy or some other rational benefit. They have permission to show the human condition, be visually dynamic, trigger curiosity, and stir emotion. By doing so, they increase the odds of delivering a "Wow!" I don't know about you, but I don't mind watching some of the above spots multiple times (can you say that about a paper towel ad?)
The growth of design thinkers, infographic illustrators, and storytellers provide new lenses to look through when attempting to create a novel concept. As such, there remains much more opportunity to innovate this time-tested tool and capture the imagination of your consumers. It's an opportune moment to not only show-off what your product can do, but to demonstrate that you understand your consumers.


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Dear Friend, 2016 is off to an exciting and productive start! As we look ahead to Pride, GAPIMNY is thrilled to introduce one of the most ambitious fundraising and engagement campaigns in our 26-year history: Proudly GAPIMNY. The goal of ... Read More
Project Announcement: The Gaysian Diaries
GAPIMNY is proud to launch The Gaysian Diaries, a new series of diary-style entries written by queer Asian and Pacific Islander (QAPI) men and transgender people. In light of GAPIMNY's 2016 theme Coming Together: Creating Safe Spaces for ... Read More
Join GAPIMNY's Pride, Social, and Welcoming Committees
Join GAPIMNY in building the queer Asian and Pacific Islander (QAPI) community in New York City and participate in one of our newly-formed Committees! In line with our 2016 theme Coming Together: Creating Safe Spaces for QAPIs, GAPIMNY ... Read More
Solidarity with CAAAV
GAPIMNY supports a vision of racial justice and LGBTQ rights that centers and supports the most vulnerable members of our community, including the struggle for police accountability. We also recognize and support CAAAV for their long ... Read More
An Update from the Steering Committee
Dear GAPIMNY Member, Thank you for being part of our family! In the spirit of connection and transparency, we are providing you with an update on the plans that emerged from the Steering Committee's annual Planning Meeting and ... Read More
GAPIMNY Supports Immigrants' Rights and Opposes ICE Raids and the Priority Enforcement Program (PEP)
GAPIMNY recently signed a petition urging the Obama Administration to end the raids led by Immigration and Customs Enforcement (ICE) targeting Central American children and families who recently came to the U.S. seeking protection from ... Read More
Why am I on the GAPIMNY Steering Committee? – Richy Lou
Richy Lou, Finance Chair 2014 - 2016 I had just moved back to NYC from grad school and had just come out to my parents. Feeling all sorts of mixed emotions, I was seeking a community where I felt safe to be who I was and supported. That's ... Read More
69 Reasons to Love GAPIMNY
As the year comes to an end, GAPIMNY counts our blessings and accomplishments from 2015. In addition to 12 monthly Steering Committee meetings, we produced 57 diverse and engaging events as listed below. That's 69 reasons for you to love ... Read More
Why am I on the GAPIMNY Steering Committee? – Danny Taing
Danny Taing, Social Chair 2014 - 2015 I moved to NYC in 2013 after having lived in Asia for 4 years. During the first few months, I experienced some reverse culture shock as I had forgotten how stressful it was to feel marginalized and ... Read More
Vote in the GAPIMNY SC 2016 Election
Members! We need your vote for the 2016 GAPIMNY Steering Committee (SC). The GAPIMNY SC manages the day-to-day operations of GAPIMNY and steers the programming of the organization. Vote here by December 28, 2015, 12pm EDT. Here is the ... Read More
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SPF Based Selinux Operating System for Multimedia Applications
Trusted Operating Systems, offer a number of security mechanisms that can help protect information, make a system difficult to break into, and confine attacks far better than traditional operating systems. However, this security will come at a cost, since it can degrade the performance of an operating system. This performance loss is one of the reasons why Trusted Operating Systems have not become popular. While Trusted Operating Systems offer an incredible amount of security, observations about computing workloads suggest that only some parts of the operating system security are actually necessary. Web servers are the best example.
Provided by: International Journal of Reviews in Computing Topic: Security Date Added: Dec 2011 Format: PDF


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Consume and monetize business intelligence throughout your entire organization.
Launch Portal securely embeds and shares reporting across apps on any device inside or outside your network. Launch Portal enables enterprises to consume and monetize business intelligence. Our software easily integrates with various Business Intelligence platforms, embedding self-service reporting into any application on any network. We satisfy your compliance needs by providing granular user access controls, comprehensive access logging, and real time alerts.
The Launch Portal technology allows for the visualization of Microsoft Office® documents, PDF files, videos and more in a secure browser for your users.
Once logged in, your users have access to dashboards and reports you choose to securely share with them. In addition to viewing from any device or network, your users will have the ability to export your dashboards and reports to a multitude of file formats that include CSV, PDF, JPEG, Microsoft Power Point and Microsoft Excel.
Key Benefits
You can brand Launch Portal with your corporate identity or your customers'
LaunchPortal Software Suite
Report Launch
Export reports from your Business Objects Enterprise system straight to your external departments, partners, and vendors
Dashboard Launch
Provides rich visual representations of your data to any application on any network.
Audit Launch
Ensure regulatory compliance with enhanced auditing and logging of all user activity
Activity Launch
Business driven report bursting, delivery, and alerting
Launch Pages
Enables business lines to make BI social through content generation and interactivity
Mobile Launch
Deliver BI to any mobile device on any network from a single server and report set
LaunchWorks worked closely with our team to understand our needs and environment to develop the right kind of content and pace. They were true consultants for an end to end BI experience: system/data architecture, training, governance strategy, and ongoing user engagement.
Connect With a Variety of Platforms
BI platforms
BI platforms including SAP Business Objects, Crystal, Cognos, Tableau, and SSRS.
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LaunchWorks is Trusted by


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Netball Victoria registrations are made through your Association, League or Club in 2017
All members of Netball Victoria are bound by our membership policies and guidelines which can be found here
What is my Netball Victoria Membership ID?
To find you Netball Victoria Membership ID (previously known as VNA) please click here and follow the prompts.
We are currently in a transition period so please check if your Association or Club have an online registration form set up. To check if online registration is available please click here and enter the name of your Association or Club.
Every member that has an existing Netball Victoria Membership number (previously known as VNA) needs to login as a "Return User". For assistance with logging in as a "Return User" to complete your registration please click here to access the Participant Login quick reference guide.
If you are unsure about the online registration process, please contact your Association or Club.
The Netball Victoria family consists of over 113,000 members who play, umpire, coach or support netball.
In order to participate in a Netball Victoria affiliated Association/Competition and/or development courses, you must be a member of Netball Victoria.
If you are not sure about the affiliation status of the Association, League or competition in which you are playing, please contact the Association, League or competition to find out.
Netball Victoria Membership for 2017 includes GST and offers the following categories:
|Players, Umpires and Coaches born on or before 31/12/1999 – (18 & over)
|Players, Umpires and Coaches born between 01/01/2000 – 31/12/2006 – (11 – 17 years)
|All Abilities
|Members with a disability on receipt of valid ID
|NetSetGO are born on or after 01/01/2007 includes participant pack
|Off the Court
|Committee Members, Administrators, Volunteers, Parents and Spectators.(PLEASE NOTE: players, coaches, umpires and bench officials must be a current senior, junior or AA member)
How to become a Netball Victoria member or renew your membership
For all 2017 registrations, please contact your club or Association to pay your registration.
It is important to note that a player must have a current membership before she/he takes the court, so you must make sure you pay before your first match.
You will be considered a current Netball Victoria member, as soon as you, your club or Association update and pay for your registration on the MyNetball database. When you complete your membership online you will received an email confirmation. Please keep a copy of this confirmation until your membership card arrives in the mail.
Membership Card
All Netball Victoria members receive a Membership Card via email. Your card acts as a proof of membership.
If you registered through your Club or Association and have not received your Netball Victoria Membership email within one month of registration, please contact Netball Victoria on (03) 9321 2222.
Updating Your Information
In conjunction with Netball Australia, Netball Victoria has introduced MyNetball as our new membership and competition platform. Netball Victoria members should receive an email (to the address supplied at registration) which provides log in details and instruction to access the MyNetball Public Portal. Here you can change your personal membership details, including updating your address and contact information.
If you have not received an email with your log in information, please contact your Association or League.


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LifeQuest Services has its primary offices in Wisconsin and Indiana. We have become an industry-leading, professional organization while still maintaining the individuality of the clients we serve.
The company was founded in 1992 by an EMT-Paramedic. Since then, LifeQuest Services has grown into a respected leader in the EMS and fire billing sectors while preserving its dedication and support to emergency professionals. We have over 200 clients across the nation that rely on us for quality service and expert advice. LifeQuest Services continues to grow its customer base and geographic footprint due to its reputation, superior collection rates and exceptional customer service.
The LifeQuest Services Team
- Certified Ambulance Coders (CAC) accredited by NAAC
- Paramedics (NREMT-P, EMT-P)
- Emergency Medical Technicians (EMT-B, EMT-I)
- Certified First Responders
- Certified Firefighters I, II and III
- American Ambulance Association Members
- Medicare Provider Education
- Certified professional Collection Specialists (CPCS) accredited by the Association of Credit Collection Professionals (ACA International)


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Beltane/Spring Fest in Cornwall-on-Hudson, NY
I'll be there reading cards, singing rowdy Beltane songs, signing books, and giving a workshop. I'll be leading a Druid worship ritual in honor of the Dagda and Danu the night before. Contact me if you want to attend the … Continue reading
Posted in Calendar, Fun, Pagan Stuff Tagged Beltaine, Beltane, Cornwall-on-hudson, festival, Neopagan, Pagan Leave a comment
Meet the Deities Halfway
There's an old story, which I will now shamelessly steal and Paganize, that goes like this: There once was a Pagan, we'll call him Dru Iolo, who was very poor. Every day he would go out to the sacred grove … Continue reading
Posted in Money, Pagan Stuff Tagged gifts, lottery, Pagan Elders, seniors, support, winnings Leave a comment
Adopt an Elder 2009
I've just spent some time updating an essay on this topic. Here's a bit from the opening: Every local Neopagan community has one, two, or more older members who may be struggling to survive on a day-to-day basis. Whether thay … Continue reading
Posted in Money, Neopagan.Net changes, Pagan Stuff, Personal Happenings Tagged help, Money, Neopagan.net updates, Pagan Elders 1 Comment
Hands of Change Pagan Picnic
That's where I'll be Saturday, August 2, from 10:00 am to 7:00 pm, at the Hands of Change Pagan Picnic, in Johnson Park, Piscataway, NJ. I'll be pontificating, giving tarot readings, and just hanging out with the New Jersey Pagans. … Continue reading
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Real Magic School Unveiled at Winterstar Festival
Phae and I had a wonderful time at Winterstar this year. Not only did we get to present workshops on healing and liturgy, but also one officially opening our Real Magic School. There was a great deal of interest from … Continue reading
Posted in Pagan Stuff, Personal Happenings, Real Magic School Tagged online classes, Real Magic School, Winterstar Leave a comment
Real Magic School opens February 29th
Phaedra and I are very excited to announce the upcoming opening of Real Magic School at www.realmagicschool.com on February 29th. This will give us the opportunity to teach both beginning and experienced students of the occult arts, Wiccans, Druids, and … Continue reading
Posted in Pagan Stuff, Personal Happenings, Tech/Geek 1 Comment
Coast to Coast AM
This is a radio program in the USA that focuses on UFOs, ghosts, cryptozoology, conspiracies, and things that go bump in the night. I was a guest a few days ago on the show, which is broadcast from 10:00pm to … Continue reading
Posted in Current Events, Magic, Pagan Stuff, Personal Happenings Tagged interview, Magic, radio, spell 2 Comments


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CodeRunner Documentation (V2.4.2)
4.3 Some more-specialised question types
The following question types used to exist as built-ins but have now been dropped from the main install as they are intended primarily for University of Canterbury (UOC) use only. They can be imported, if desired, from the file uoc_prototypes.xml, located in the CodeRunner/coderunner/db folder.
The UOC question types include:
python3_cosc121. This is a complex Python3 question type that's used at the University of Canterbury for nearly all questions in the COSC121 course. The student submission is first passed through the pylint source code analyser and the submission is rejected if pylint gives any errors. Otherwise testing proceeds as normal. Obviously, pylint needs to be installed on the sandbox server. This question type takes the following template parameters (see the section entitled Template parameters for an explanation of what these are) to allow it to be used for a wide range of different problems:
isfunction: unless this is explicitly set to false, a dummy module docstring will be inserted at the start of the program unless there is one there already. Thus, if your question is of the "write a program" variety, you should set this to false. Otherwise omit it. This purpose is to stop pylint issuing a spurious missing module docstring message.
pylintoptions: this should be a JSON list of strings. For example, the Template parameters string in the question authoring form might be set to {"isfunction": false, "pylintoptions":["--max-statements=20","--max-args=3"]} to suppress the insertion of a dummy module docstring at the start and to set the maximum number of statements and arguments for each function to 20 and 3 respectively. See the pylint documentation for a list of its options.
proscribedconstructs: this is a list of Python constructs (if, while, def, etc) that must not appear in the student's program.
prescribedconstructs: this is a list of Python constructs (if, while, def, etc) that must appear in the student's program.
allowglobals: set this to true to allow global variables (i.e. to allow lowercase globals, not just ALL_CAPS "constants")
maxnumconstants: the maximum number of constants (i.e. uppercase globals) allowed. An integer, defaulting to 4. Such such constraint is required when teaching pylint at early stages to stop students achieving pylint compliance with a global script simply by typing all identifiers in upper case.
norun: if set to true, the normal execution of the student's code will not take place. Any test code provided will however still be run. This is intended for dummy questions that allow students to check if their code is pylint-compliant.
stripmain: if set to True, the program is expected to contain a global invocation of the main function, which is a line starting "main()". All such calls to main are replaced by 'pass'. If no such line is not present a "Missing call to main" exception is raised.
runextra: if set (to any value) the Extra Template Data is added to the program as test code before the usual testcode. This allows the question author to load extra test code through the Extra Template Data which the student does not get to see (usually because it would confuse them).
matlab_function. Used for Matlab function questions. Student code must be a function declaration, which is tested with each testcase. The name is actually a lie, as this question type now uses Octave instead, which is much more efficient and easier for the question author to program within the CodeRunner context. However, Octave has many subtle differences from Matlab and some problems are inevitable. Caveat emptor.
matlab_script. Like matlab_function, this is a lie as it actually uses Octave. It runs the test code first (which usually sets up a context) and then runs the student's code, which may or may not generate output dependent on the context. Finally the code in Extra Template Data is run (if any). Octave's
dispfunction is replaced with one that emulates Matlab's more closely, but, as above: caveat emptor.


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So insipring!
Noble role models such as Jimmy Carter help awaken the divinity in humankinds souls; turning our planet from greed and war zones into a planet filled with creativity, hope, love and sharing. He inspires us through example, with many wonderful ways to be of service to others.
View original post 82 more words


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What it says in the papers: business pages
Here are the main business stories from this morning's papers:
Irish Independent
* Drug giant Pfizer and Ireland-based Allergan walked away from a $160bn merger deal yesterday in what is a major victory for President Barack Obama in his fight to block US companies shifting their tax liabilities abroad.
Pfizer admitted the decision to kill the deal - which would have created Ireland's biggest company - was a result of new US Treasury rules unveiled just this week.
* Staff at the Irish units of internet giant Amazon are set to reap a total of almost $50m (€44m) worth of share awards this year and in 2017.
The move comes as Jeff Bezos, the founder of the world's most valuable retailer, this week extolled Amazon as "the best place in the world to fail".
* Stalled infrastructural projects now threat to derail the recovery in the regions.
The warning came as the Construction Industry Federation (CIF) urged the new Government to set firm start dates for more than €1bn worth of investment schemes planned for outside Dublin.
The Irish Times
* Staff at Goodbody Stockbrokers have increased their stake in the firm to 49pc over the last five years, according to a report in The Irish Times.
Recovery in the stock market, paired with corporate transactions has helped the firm's staff get to its maximum stake target under the deal agreed with Kerry-based Fexco, which took it over in 2011.
* The BBC has acquired TV3 soap 'Red Rock' and is to air double episodes of the show in a daily lunchtime slop this summer.
The British national broadcaster purchased the first 80 episodes of the show through All3Media earlier this year.
* Irish consumer sentiment has recorded its largest monthly drop in 17 months following an inconclusive election in February, according to the latest KBC Bank Ireland/ ESRI survey.
The report showed a drop of its main index down to 100.6 from 105.8, bringing it down to a six-month low. Political instability was linked to the dip in confidence amongst consumers.
Irish Examiner
* Social media giant Facebook has brought forward its plans to build a second building at its data centre in Clonee Co Meath.
The move is in response to demand since Facebook's announcement about the data centre in January. As a result the second building will now be built concurrently with the first.
* The number of mortgages approved in the year to February fell by 15.1pc according to the latest monthly report from the Banking and Payments Federation Ireland.
The report shows an average of 1,951 mortgages were approved each month in the three month period that ended in February.
* Accounts filed by Bowe's Tommy Bowe Sports Ltd to Companies House in the UK show accumulated profits of £256,634 (€317,810) at the end of March 2015.
The firm's accumulated profits dropped from £274,992 during the period.
Online Editors
Promoted Links
Related Content
- Pfizer-Allergan break-up lets markets eye M&A
- Amazon's staff in Ireland set for $50m share windfall over two years


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Price may exclude tax, title, tags, governmental fees, any emissions testing charges and any finance charges (if applicable). Unless otherwise stated separately in the vehicle details, price does not include documentation, processing, administrative, closing or similar fees. Current mileage may vary due to test drives and vehicle relocation.


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BP is a global company that is involved in the extraction, refinement and the sale of fuel. This major company has operations in around 80 countries across the globe, and has more than 83,000 employees. BP is ranked as the second-largest provider of fuel in America, and it is estimated that it sells more than 15 billion gallons of fuel in America alone, each year. With employees needed at every step of the process, BP applications are often submitted in large numbers for each position, so when you do apply for jobs at BP, make sure your application stands out.
As well as gasoline, BP also manufactures petrochemicals and lubricants, and energy that is needed to generate light and heat. This company is also known for it's contributions towards developing alternative energy sources, and this includes biofuels and wind energy. Other brands associated with BP include Wild Bean Café, ampm, Castrol and Aral.
The story of BP is quite an interesting one. Back in 1901, a group of British geologists were sent to Iran to drill for oil under the instruction of a gentleman called William D'Arcy. A man named George Reynolds, which despite a long list of problems and failures, refused to give up, convinced there was oil beneath the sand, led them. Finally, in 1908 they finally struck oil. Within one year, the company was formed under the name the Anglo-Persian Oil Company, which would later become BP (British Petroleum). From there, the company continued to grow, until becoming the global phenomenon it is today.
BP Careers
BP careers are very actively pursued, due to the vast number of job opportunities, locations and benefits. Many positions are suitable for entry-level workers, and often they need little or no experience at all. With more than 7,500 gas stations throughout the US, there are a constant number of BP jobs available. Not only do these stations require forecourt staff to manage the fuel transactions, there are also positions for food preparation for the cafes, customer service and cashiers, ad merchandising.
As well as the entry-level careers, there are many corporate level positions as well. Some of these include chemical engineers, construction engineers, business support, crisis management, communications, and compliance and ethics. These positions require additional qualifications and work experience, as they are highly technical jobs. Also there are employment opportunities in the areas of finance, human resources, procurement, and supply chain management, legal, and trading operations.
How old do you have to be to work at BP? You must be at least 18 years of age to work for BP.
There are many benefits for eligible employees when working for BP. To start with they encourage ongoing learning and development, with the ability to study online or taking courses under the care of a mentor. This enables the employee to advance their career within the company. There are also health benefits, including medical coverage and dental insurance, and 401(k) retirement plans. The reward packages for employees are amongst the best in the industry. Hours of work will vary between locations and departments, but stations are generally open 24 hours per day, 7 days per week.
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Job Descriptions & Salaries
Customer Service Representative – This includes cashiers, sales associates and stockers, and they are often called counter clerks or gas station attendants. The main portion of the role is customer service. Fuel transactions and cash handling are important duties, and stocking the floor displays and shelves, as well as preparing and packaging food items that are premade. Housekeeping is another duty expected to be completed by customer service representatives. This entry-level job usually pays between minimum wage and $9.00 per hour.
Finance Analyst – The main responsibilities of the finance analyst are to provide reports on financial performance, analysis and forecasting for the section they are working in. The analyst must prepare cost analysis and assist with the preparation and submission of the Group Financial Outlook. This is a highly specialized role, and formal qualifications and experience are necessary. The average salary is around $77,600 per annum.
Project Manager – There are different project managers required for the various areas of the BP global operation. An Area Project Manager is responsible for the delivery of engineering projects and modifications for assigned assets from Appraise through Execute and into operation. So basically they are required to manage a project from the beginning right through to the end. They are also responsible for developing financial memoranda so that the appropriate funding required is assigned. The salary varies, but the average is around $128,000 per year.
Drilling Engineer – For this role, you must have a degree in engineering. The principle responsibility is to lead the team and provide engineering assurance at the individual project level and making sure the designs or programs meet their standards and regulatory policies. Most of the duties will depend on the location and project assigned, and the specifics of the role will vary. The average salary is around $128,800 per annum.
BP Interview Questions
The questions asked at BP interviews will depend on what type of position you are applying for, but some will be asked across all disciplines.
Do you prefer to work individually or within a team? This question will determine your suitability for the role you have applied for, as some positions will be team-based and some will be more individual. Be honest with your answer, as there is no point saying you like working in a team if you really don't, you'll just be unhappy.
What parts of your education do you see as relevant for this job? This is to find out what skills you have specifically and how they can be applied to the job. Think about the job you are applying for, and what you have studied previously and how it can be utilized in this position.
Do you work well under pressure? This is a very important question for jobs within this industry, as some of the positions do carry a level of pressure. If you are new to the workforce, you could use a pressure situation such as exams to provide you with an example. Don't be untruthful, as this is a very important factor and could lead to unsafe work environments if you really don't handle pressure well.
How do you react to instruction and criticism? Many BP jobs are entry-level positions, so ongoing training will be required. If you don't handle criticism well, this is something you would need to work on. Answer this question the best you can, and be honest.
What is your greatest achievement outside of work? Employers sometimes ask this question to find out more about your activities outside of work, and whether you are the type of person that strives to reach goals. Use an example of a sporting achievement, club achievement or an educational goal you have reached. Whatever it is that you feel the proudest about.
Advice For Application Process
To submit a BP application, you will need to either look at their official website or search for BP jobs online. Once you have found a job that they are hiring for, it is easy to find out how to apply for BP online by looking under the careers section on the official website. There is no download application form, therefore no printable application form, so it is not possible to make a direct application at your local office. If you do find a printable application for BP, make sure it is a legitimate and acceptable online application form. When you apply online, attach a cover letter and a copy of your resume to your application before you submit it.
This company conducts interviews in a few different ways. There are telephone interviews, usually in the first instance, then face-to-face interviews or virtual interviews for those who do not live locally. To prepare for a telephone interview, practice and record yourself to see how you sound. Try not to make too many 'um' or 'ah' noises. Make sure you give the interviewer plenty of time to speak, and try not to talk over them or interrupt.
Before going to a face-to-face interview, do some research online into the company, such as what they do, why they do it, and where they do it? Knowing their values and behaviors will give you a good advantage. Also study your resume to make sure you know it off the top of your head. These types of interviews are based on competency, so often there is no right answer to a question, but they want to see how you approach the question and reach your answer. If you are applying for a technical position, there may be questions more directly related to your field of expertise or experience.
Also See:
Chevron: Visit the job application for Chevron to apply today.
Texaco: For employment at Texaco visit the application page.
Love's: Checkout the application page for work at Love's.
Phillips 66: See our resource page for more information on Phillips 66 careers.
Conoco: Visit the job application for Conoco to apply today.
Company Links


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FAIRFIELD (KRON)—A Fairfield man was arrested Wednesday afternoon after police allegedly found marijuana, cocaine, prescription medication and a gun inside his car, according to police.
An officer spotted a suspicious car near Union Food and Liquor and was able to see drugs inside the car as he walked closer to it, police said.
The driver, who has been identified as 23-year-old Billy Breedlove, refused to open the door, but eventually unlocked it, according to police.
The officer found the drugs and gun inside the car.
Breedlove was arrested on suspicion of a possession of a controlled substance for sale, possession of marijuana for sale, possession of a controlled substance while armed and possession of a loaded firearm with intent to commit a felony, according to police.
He was booked into the Solano County Jail and is being held on a $155,000 bail.


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Would you like to save as your currency permanently or for this visit only?
PROPERTY DESCRIPTION The Junyue Hotel is located at the center of southwest downtown of Sanshui District close to Cultural Park and Shatou New District. It is 29 kilometers from Foshan Airport.Remodeled in 2005 the 5-story hotel features 114 rooms.The hotel property include western and Chinese restaurants sauna foot massage karaoke room and parking lot. 29km to Foshan Airport.-39km to Foshan Railway Station.-1.2km to Sanshui Railway Station


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|Web Links
|i-board Me and Us Y1 Ourselves science clips Virtual Body How we Change as we grow BBC video Name Body Parts Label Body Parts Body Functions Body Systems Y4 Moving and Growing science clips Y4 Moving and Growing
|The Skeleton Which bone? Skeletons Skeleton Build a Skeleton Skeletons and Muscles Moving & Muscles Quiz Bones or Boneless? Muscles Quiz Skulls and Skeletons Animal X-rays Heart and Circulation The Digestive System


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A basic love seat and bobbin lighting configuration hand selected by our stylists. We pay shipping...


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Wednesday, December 13, 2017
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Weighted and Two Stage Least Squares Estimation of Semiparametric Truncated Regression Models
This paper provides a root-n consistent, asymptotically normal weighted least squares estimator of the coefficients in a truncated regression model. The distribution of the errors is unknown and permits general forms of unknown heteroskedasticity. Also provided is an instrumental variables based two stage least squares estimator for this model, which can be used when some regressors are endogenous, mismeasured, or otherwise correlated with the errors. A simulation study indicates the new estimators perform well in finite samples. Our limiting distribution theory includes a new asymptotic trimming result addressing the boundary bias in first stage density estimation without knowledge of the support boundary.
If you experience problems downloading a file, check if you have the proper application to view it first. In case of further problems read the IDEAS help page. Note that these files are not on the IDEAS site. Please be patient as the files may be large.
|Date of creation:
|14 Feb 2002
|Date of revision:
|04 Sep 2006
|Contact details of provider:
| Postal: Boston College, 140 Commonwealth Avenue, Chestnut Hill MA 02467 USA
Phone: 617-552-3670
Fax: +1-617-552-2308
Web page: http://fmwww.bc.edu/EC/
More information through EDIRC
References listed on IDEAS
Please report citation or reference errors to , or , if you are the registered author of the cited work, log in to your RePEc Author Service profile, click on "citations" and make appropriate adjustments.:
- Lee, Myoung-jae, 1989. "Mode regression," Journal of Econometrics, Elsevier, vol. 42(3), pages 337-349, November.
- Powell, James L, 1986. "Symmetrically Trimmed Least Squares Estimation for Tobit Models," Econometrica, Econometric Society, vol. 54(6), pages 1435-1460, November.
- Arthur Lewbel, 1998. "Semiparametric Latent Variable Model Estimation with Endogenous or Mismeasured Regressors," Econometrica, Econometric Society, vol. 66(1), pages 105-122, January.
- Powell, James L., 1986. "Censored regression quantiles," Journal of Econometrics, Elsevier, vol. 32(1), pages 143-155, June.
- Lewbel, Arthur, 2000.
"Semiparametric qualitative response model estimation with unknown heteroscedasticity or instrumental variables,"
Journal of Econometrics,
Elsevier, vol. 97(1), pages 145-177, July.
- Arthur Lewbel, 1999. "Semiparametric Qualitative Response Model Estimation with Unknown Heteroskedasticity or Instrumental Variables," Boston College Working Papers in Economics 454, Boston College Department of Economics.
- Honore, Bo E. & Powell, James L., 1994. "Pairwise difference estimators of censored and truncated regression models," Journal of Econometrics, Elsevier, vol. 64(1-2), pages 241-278.
- Lee, Myoung-jae, 1993. "Quadratic mode regression," Journal of Econometrics, Elsevier, vol. 57(1-3), pages 1-19.
- Lee, M.J., 1990. "Quadratic Mode Regression," Papers 9-90-10, Pennsylvania State - Department of Economics.
- Newey, Whitney K. & McFadden, Daniel, 1986. "Large sample estimation and hypothesis testing," Handbook of Econometrics,in: R. F. Engle & D. McFadden (ed.), Handbook of Econometrics, edition 1, volume 4, chapter 36, pages 2111-2245 Elsevier.
- Pakes, Ariel & Pollard, David, 1989. "Simulation and the Asymptotics of Optimization Estimators," Econometrica, Econometric Society, vol. 57(5), pages 1027-1057, September. Full references (including those not matched with items on IDEAS)