text:
Sound Off for Sunday, April 13, 2014
On city eyesores: The first impression of Janesville coming in on Highway 14 between North Wright Road and Pine Tree Plaza is pitiful. It looks like a garbage truck dumped over. Isn't somebody going to clean up the mess? The bike trails are a sorry sight for Janesville.
-- The South Jackson Street bridge is getting to be a big eyesore. That plastic fence they have up will not stop a car from going into the river.
On cellphone use: If you're driving along Milton Avenue and the driver next to you has their head bowed, they're not praying, they're texting. What they should be doing is praying they don't kill some innocent person because of their stupidity.
On test scores: The Gazette on April 8 could have presented several other ways to look at the Janesville School District's test results. First, eight of 14 district scores in math and reading declined from last year. Second, compared to last year, 53 individual school scores declined out of a possible 94. Also, there was no mention of minority student test scores.
-- Page 2A Wednesday says "Test scores lag in voucher schools." The voucher schools need to grow. They accept students who can't read or do math up to high school levels because public schools didn't take the time with them and do the job. Parents can see that and make a good choice.
On Paul Ryan: He continues promoting vouchers for Medicare. Would someone please tell him that on Nov. 6, 2012, he and Mitt lost the election by over 5 million votes? He's closed.
On Gov. Walker: A caller in Wednesday's Sound Off says Gov. Walker acts like a spoiled little rich kid. No, actually the spoiled little rich kid is running against him. Her name is Mary Burke.
-- Regarding Wednesday's Sound Off about Walker in Las Vegas, the hypocrisy of the Left never ceases to amaze me. They can find fault with Walker and his associates but not a word on all the vacations, play dates and campaigning the president does with his billionaire buddies. When are we all going to hold all politicians accountable for what they do?
-- This is on Walker not having a college degree. Let's compare his job performance with the other 49 governors and tell me who's doing a better job. Now let's look at our president, who holds two degrees from prestigious universities, Harvard and Columbia, and he has mucked up everything he has touched. Apparently a college degree is not that important.
On fire department: It's terrible that they would take homes away from people to build a new fire station. They need to look for land they can use or some of these empty buildings they can use and let these people keep their homes. Get rid of the city council. We need a mayor. No more of these city council people; they make poor decisions.
-- If firefighters worked like they do at the police department with 12-hour shifts, they wouldn't have to have a dormitory for male and female persons. The hospital works on a 12-hour shift, too. There's no reason why the fire department can't do the same thing.
On columnist: I commend Kathleen Parker for her column Tuesday, "Democrats keep demonizing the Koch brothers." I found her article to be refreshing, telling it like it is.
On dead woman: This is in reference to the article on Tuesday, April 8, on Page 7A. My heart goes out to the family of Alejandra Guzman-Flores, whose body was found in Jefferson County in a cornfield. The article was good except it doesn't show a picture of her. That would help people to know if they saw or had contact with her.
On police reports: I couldn't agree more with Wednesday's Sound Off. They never put in the paper who is found innocent. Further, there should be a law against looking people up while at work and harassing or gossiping about them on the job. The Internet is never completely thorough about their arrest and what happened.
On police honors: I heard the Janesville Police Department issued officer of the year and a number of other awards. Three of the four or five were graduates of schools in Janesville. I know there was a press release provided by the Janesville Police Department, yet nothing was printed in The Gazette, and I wonder why.
On Milton meeting: Milton Mayor Frazier wants another listening session on the Highway 26 bypass, allowing him to control what he hears from the public. There have been many closed sessions at council meetings, denying the public the right to know what their city government is discussing. How about fewer listening sessions and more open meetings?


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'Star Wars: Episode 7′ – J.J. Abrams Will Direct!
The search for a 'Star Wars: Episode 7' director is over. J.J. Abrams – the man who once said he would only be interested in 'Star Wars' as a paying moviegoer – will direct the first film in the new trilogy.
The Wrap is reporting that J.J. Abrams will direct 'Star Wars: Episode 7′ after a long courtship from producer and new Lucasfilm head Kathleen Kennedy. It should be noted that Kennedy was a longtime producer for Steven Spielberg, a good friend and mentor for Abrams. (Interestingly, the report claims that Ben Affleck was the runner-up for the job.) Deadline now confirms the report saying that it's a "done deal."
Abrams had been talking about shooting a new, original film after wrapping 'Star Trek Into Darkness' but that will have to be put on hold as he moves from one 'Star' franchise to another.
Before we get into what this means for 'Star Wars: Episode 7,' let's quickly talk about what this means for 'Star Trek.' Abrams has long made his home at Paramount, directing all of his movies with the studio, which also serves as the home of his production company Bad Robot. This surely means that 'Star Trek Into Darkness' will be Abrams' last 'Star Trek' movie, a decision that will surely upset the people at Paramount and a loyal fan base. Will Abrams be able to produce 'Star Trek 3′ while filming 'Star Wars: Episode 7?'
As for 'Star Wars,' there probably was no director out there that was more of a perfect fit for the job than Abrams. It seems as if it's who Lucasfilm wanted all along and Abrams, a longtime 'Star Wars' fanatic, probably wanted the job more than he let on publicly. While the story will be that they had to woo him, we can't imagine they had to wine him and dine him for too long.
Another issue is that Abrams fancies himself a writer, one who's comfortable working with a familiar crew of colleagues. What will this mean to the current script that's being developed by Oscar-winning screenwriter Michael Arndt? Will Abrams want the power to rewrite? Has Abrams secretly been taking meetings with Arndt to inflect his own ideas on the film?
It may not be the most daring or surprising choice in the world, it certainly is a choice that a) makes sense and b) immediately gets one excited about the quality of the new era of 'Star Wars.'

subset: commoncrawl


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Walworth County warden named top water cop
MADISON--A Wisconsin conservation warden who patrols Walworth County lakes has been named the nation's top cop on the water by a national boating organization.
Juan Gomez, a Wisconsin warden since 2008, was selected from 43 officers nominated for an honor awarded last month by the National Association of State Boating Law Administrators.
"Juan has represented our department at its highest level," Wisconsin Chief Conservation Warden Randy Stark said in a prepared statement. "Juan is known for his commitment to safe boating where he is stationed, which is a highly populated area with 30 lakes, including the popular tourist area of Lake Geneva."
Gomez has been proactive in addressing the problem of operating while intoxicated, organizing special enforcement efforts at several large events in southeastern Wisconsin.
Gomez and up to a dozen wardens monitor the Lake Beulah Tie Up, for example, and some years make 10 or more OWI arrests.
"The Lake Beulah Tie Up is a scaled-down version of the Lake Okauchee Tie Up … Last year we only had two OWIs, (at Lake Beulah). The year before it was 10," he said.
Earning the award does not mean Gomez wrote the most citations for violating boating regulations, said Todd Schaller, the Department of Natural Resources section chief for recreational enforcement and education.
Gomez achieves high marks in community policing, boating safety education and enforcement, Schaller said.
"It's not just writing tickets but engaging the public and users to find solutions to problems," Schaller said.
Whether those solutions mean posting better advisories at boat landings or working closely with local law enforcement or lake associations, Gomez has been successful in all areas the DNR and national association prizes for public service, Schaller said.
Gomez prefers education to enforcement and annually conducts three to four safe boating clinics. Last year he certified 105 students as safe operators.
Trouble occurs when people haven't been instructed to operate water craft. Gomez and fellow warden Jason Roberts were on Lake Beulah, saw three people fall off a jet ski. The jet ski kept moving and Gomez prevented it from colliding with a pier and helped the three people out of the water.
Gomez said inexperience lead to the incident.
"They weren't aware they had to wear the lanyard that cuts off the machine if the operator falls off," he said.
After the summer recreational boaters leave the lakes, Gomez remains on patrol to check duck hunters and fishers for life jackets and fire extinguishers, sometimes until the water freezes.
"I'll be out on the water until December. (Geneva Lake) is one of the last in my area to freeze up," he said.
Then it's patrolling for snowmobilers as conditions permit, all-terrain vehicles and ice fisherman.
The seasons dictate the warden's activities, something Gomez said he appreciates.
"The summers are long, and by the end of summer I'm ready for it to be over. The fall becomes super busy with all the hunting that happens, and by the end of November I'm ready for that to end, too," he said.
There is no cash bonus or commendation for earning the national award, and Gomez said the award would not have been possible without a supportive team of wardens and the department behind him.
"It's a great team that assists with everything that I was nominated for," he said.
Schaller counts modesty among Gomez's qualities.
"Whether he's working with individuals or groups, he a very good people person, that's one of the reasons he succeeds in this business," Schaller said.
Gomez is the third Wisconsin warden to win the award in recent years. Ben Treml won in 2011, and Roger Hanson won in 2000. Both are Green Bay area wardens.


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Gentian Violet Vs. Nystatin Oral Suspension for Treatment of Oropharyngeal Candidiasis
This study has been completed.
AIDS Clinical Trials Group
ClinicalTrials.gov Identifier:
First Posted: September 2, 2011
Last Update Posted: February 16, 2015
National Institute of Allergy and Infectious Diseases (NIAID)
Information provided by (Responsible Party):
AIDS Clinical Trials Group
- Full Text View
- Tabular View
- Study Results
- Disclaimer
- How to Read a Study Record
Detailed Description:
The purpose of this study was to see which one of two medicines (topical gentian violet [GV] or nystatin oral suspension) was better than the other in treating Oral Candidiasis (OC). This was measured by whether the study participant still had OC or sores in his/her mouth after 14 days of treatment. Also, safety and tolerability of GV and nystatin in the treatment of OC were assessed.
|HIV-1 Infection
|Drug: Gentian Violet Drug: Nystatin oral suspension
|Phase 3
|Study Type:
|Study Design:
|Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
|Official Title:
|A Phase III, Open-Label, Randomized, Assessment-Blinded Clinical Trial to Compare the Safety and Efficacy of Gentian Violet Oral Solution to That of Nystatin Oral Suspension for the Treatment of Oropharyngeal Candidiasis in HIV-1 Infected Participants in Non-U.S. Settings
Resource links provided by NLM:
MedlinePlus related topics: HIV/AIDS Yeast Infections
Drug Information available for: Methylrosanilinium chloride NystatinU.S. FDA Resources
Further study details as provided by AIDS Clinical Trials Group:
Primary Outcome Measures:
- Number of Participants With Clinical Efficacy [ Time Frame: After 14 days of treatment ]The primary endpoint is clinical efficacy defined as cure (absence of lesions) or improvement (a decrease in severity of lesions) after 14 days of treatment. The oral cavity will be split arbitrarily into 6 sites: left lower and upper labial mucosa and buccal mucosa, right lower and upper labial mucosa and buccal mucosa, hard palate, soft palate, tongue (dorsum, lateral, and ventral), and floor of mouth. Severity is scored using a scoring system from 0 to 3 (0 corresponds to absence of lesions, and 3 corresponds to presence of extensive confluent lesions) which leads to a composite severity score ranging from 0 to 18 after adding up the scores from all 6 sites. Complete success is assigned if the composite score after treatment equals to 0. Improved/partial response is assigned if the composite score after treatment is less than the baseline score. The blinded evaluator scores the severity of lesions by examining different lesion characteristics.
Secondary Outcome Measures:
- Number of Participant With Symptom [ Time Frame: after 14 days of treatment ]Symptoms were assessed using a visual analog scale where the level of discomfort and pain were recorded and quantified using a scoring system from 0 to 3. 0=no discomfort/pain; 1=mild discomfort/pain; 2=Moderate discomfort/pain; 3=Severe discomfort/pain.
- Quantitative Yeast Colony Counts [ Time Frame: At weeks 0, 2, 6 ]If quantitative yeast culture yielding < 20 CFU/mL of Candida spp., then we call this mycological success
- Tolerance [ Time Frame: After 14 days of treatment ]The investigators will measure tolerance using a scale from 0 to 3 (0=No side effects experienced, no changes in treatment; 1=Some side effects experienced, but not enough to modify treatment; 2=Some side effects experienced, resulted in treatment interruption; 3=Side effects experienced, resulted in treatment discontinuation.)
- Number of Participants Who Were Adherent. [ Time Frame: After 14 days of treatment ]Adherence was reported as a dichotomous variable (adherence vs. non-adherence). Participants who have missing doses less than 15% will be considered as adherent, i.e., if a participant is in the GV arm, then the cutoff point is 28*0.15=4 doses; and for the nystatin arm is 56*0.15=8 doses.
- Self-Assessment of General Health [ Time Frame: Weeks 0, 6 ]Participants rated their general health on two scales. One is a five point scale ranging from 1 to 5 (1=Excellent; 2=Very Good; 3=Good; 4=Fair; 5=Poor)
- Number of Participants Who Found GV and Nystatin Acceptable. [ Time Frame: After 14 days of treatment ]Acceptability was defined as the willingness to use the drug if it is proven effective to treat oral candidiasis. Participants were asked whether or not they would be willing to use the assigned treatment via questionnaires.
|Study Start Date:
|June 2011
|Study Completion Date:
|January 2014
|Primary Completion Date:
|September 2012 (Final data collection date for primary outcome measure)
|Assigned Interventions
Experimental: Arm A: Topical GV solution
Topical GV 0.00165% solution (5 mL swish and gargle for 1 minute and expectorate [spit] 2 times per day [BID]) for 14 days
Drug: Gentian Violet
Participants were administered topical Gentian violet solution, orally, twice daily for 14 days.
Active Comparator: Arm B: Nystatin oral suspension
Nystatin oral suspension (5 mL of 100,000 units/mL swish for 1 minute and swallow 4 times per day [QID]) for 14 days
Drug: Nystatin oral suspension
Participants were administered Nystatin oral suspension 4 times a day for 14 days.
Detailed Description:
A5265 was a phase III, open-label (both the researchers and participants know which treatment was being administered) clinical trial to compare the safety and efficacy of topical GV to that of oral nystatin suspension. Male and female HIV-1 positive participants ≥ 18 years of age were randomized (as if by the toss of a coin) with equal probability and stratified by CD4+ T-cell counts and the use of antiretroviral therapy at the time of study entry to receive either topical GV solution (5 mL swish and gargle for 1 minute and spit two times daily) or nystatin oral suspension (5 mL swish for 1 minute and swallow four times daily) for 14 days. Therapy was considered as failed if participants have no clinical improvement (assessed by severity of pseudomembranous candidiasis) during either treatment regimen. Evaluation of signs and symptoms of oral candidiasis was done by an evaluator who was blinded to the treatment assignment. A total of 494 participants was expected to enroll in the study but due to early study closure only 221 enrolled; and participants are expected to be on the study for about 13 weeks.
Information from the National Library of Medicine
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
|Ages Eligible for Study:
|18 Years and older (Adult, Senior)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- HIV-1 infection, documented by any licensed rapid HIV test or HIV enzyme or chemiluminescence immunoassay (E/CIA) test kit at any time prior to study entry and confirmed by licensed Western blot or a second antibody test by a method other than the initial rapid HIV and/or E/CIA, or by HIV-1 antigen, plasma HIV-1 RNA viral load.
- Pseudomembranous candidiasis documented by a complete oral exam (i.e., white or yellow spots or plaques with an underlying erythematous base, located in any part of the oral cavity) at the screening visit. Participants with documented angular chelitis and/or erythematous candidiasis without pseudomembranous candidiasis were not eligible to enroll in the study.
- If on an antiretroviral therapy (ART), initiation of regimen at least 12 weeks prior to study entry, and willingness of participant to remain on current ART regimen until the study-defined 14-day treatment period was complete. NOTE: Participants who were not ART-naïve and not on ART were eligible to participate in the study if they did not intend to initiate ART during the study- defined 14-day treatment period.
- CD4+ cell count obtained within 30 days prior to study entry at a DAIDS-approved laboratory.
Exclusion Criteria:
- Documented or presumptive signs or symptoms of esophageal candidiasis (e.g., dysphagia) during the screening period unless endoscopic examination of the esophagus was performed, and fungal esophagitis were excluded.
- Use of any investigational drug currently or within 30 days prior to study entry. NOTE: For purposes of this study, drugs available under an FDA-authorized expanded access program was NOT considered investigational.
- Concurrent vaginal candidiasis within 21 days prior to study entry.
- Use of inhaled or systemic corticosteroids within 14 days prior to study entry.
- Use of any antifungal agents within 30 days prior to study entry.
- Anticipated need for systemic or oral/topical antifungal agents for other diagnoses within the study-defined 14-day treatment period.
- Intend to initiate ART during the screening period, at study entry, or within the study-defined 14-day treatment period.
- Intend to use any additional oral topical treatments within the study- defined 14-day treatment period.
- Known allergy/sensitivity or any hypersensitivity to components of study drugs or their formulation.
- Active drug or alcohol use or dependence that, in the opinion of the site investigator, would interfere with adherence to study requirements.
- Serious illness, in the opinion of the site investigator, requiring systemic treatment.
- Hospitalization within 30 days prior to study entry for HIV or HIV-related conditions.
- Previous or current history of porphyria.
- Presence of oral warts during the screening period or at the study entry visit before randomization.
- Current wearing of full dentures or a maxillary partial denture at study entry
Contacts and Locations
Information from the National Library of Medicine
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01427738
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01427738
|Gaborone Prevention/Treatment Trials CRS (12701)
|Gaborone, Botswana
|Molepolole Prevention/Treatment Trials CRS (12702)
|Molepolole, Botswana
|BJ Medical College CRS (31441)
|Pune, Maharashtra, India, 411001
|National AIDS Research Institute Pune CRS (11601)
|Pune, Maharashtra, India, 411026
|AMPATH at Moi Univ. Teaching Hosp. Eldoret CRS (12601)
|Eldoret, Kenya, 30100
|Walter Reed Project - Kenya Med. Research Institute Kericho CRS (12501)
|Kericho, Kenya, 20200
|College of Med. JHU CRS (30301)
|Blantyre, Malawi
|South Africa
|Durban Adult HIV CRS (11201)
|Durban, South Africa, 4013 SF
|Joint Clinical Research Centre (JCRC) (12401)
|Kampala, Uganda
|UZ-Parirenyatwa CRS (30313)
|Harare, Zimbabwe
Sponsors and Collaborators
AIDS Clinical Trials Group
National Institute of Allergy and Infectious Diseases (NIAID)
|Study Chair:
|Robert A Salata, MD
|Case CRS
|Principal Investigator:
|James G Hakim, MD
|UZ- Parirenyatwa CRS
|Principal Investigator:
|Tim Hodgson, MD
|Eastman Dental Hospital
|Principal Investigator:
|Richard J Jurevic, DDS, PhD
|Case CRS
|Principal Investigator:
|Pranab K Mukherjee, PhD, MSc
|Case CRS
|Principal Investigator:
|Cissy M Kityo, MBChB, MSc
|Principal Investigator:
|Rana Traboulsi, MD
|Case CRS
|Principal Investigator:
|Srikanth P Tripathy, MD, MBBS
|NARI Pune CRS
|Principal Investigator:
|Mahmoud A Ghannoum, Phd, MSc
|Case Western Reserve University
More Information
Additional relevant MeSH terms:
|Responsible Party:
|AIDS Clinical Trials Group
|ClinicalTrials.gov Identifier:
|NCT01427738 History of Changes
|Obsolete Identifiers:
|Other Study ID Numbers:
1U01AI068636 ( U.S. NIH Grant/Contract )
|First Submitted:
|November 3, 2010
|First Posted:
|September 2, 2011
|Results First Submitted:
|January 6, 2015
|Results First Posted:
|February 16, 2015
|Last Update Posted:
|February 16, 2015
|Last Verified:
|February 2015
Additional relevant MeSH terms:
Pharmaceutical Solutions
Gentian Violet
Anti-Bacterial Agents
Anti-Infective Agents
Antifungal Agents
Membrane Transport Modulators
Molecular Mechanisms of Pharmacological Action
Anti-Infective Agents, Local


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Your Views: We must honor commitment to those who sacrificed much
Memorial Day means a great many things to a great many people. To some it simply represents the beginning of barbecue, boating and ball season or the end of another school year and the challenges to be faced by new graduates.
We must never forget, however, that the true meaning of Memorial Day is to honor those who made the ultimate sacrifice to this great nation by giving their lives during armed conflict. It is on this day that we stand and give pause, thoughts and prayers for those who died in the line of duty while serving our country.
The origins of Memorial Day observances can be traced from the Civil War and continue in many unique ways, right through the recent return of Rock County veterans who took part in the 2014 VetsRoll in Washington, D.C. What an honor it was to stand Wednesday and welcome home our area vets who made the once-in-a-lifetime sojourn to our nation's capital to honor their fallen comrades.
This year's observance comes during a backdrop of a Veterans Administration scandal. When our young men and women are asked to go into armed conflict, they do so without asking questions. When they come home and need Veterans Administration help in later years, they assume the covenant between them and the nation will be honored.
We must ensure our commitment to these heroes is as strong as theirs was to us.


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The following treatment approaches are often effective for treating social anxiety disorder. You can learn these techniques during counseling or treatment by a mental health provider.
Cognitive Behavior Therapy
Cognitive behavior therapy is very useful in treating social anxiety disorder. The central component of this treatment is exposure therapy or systematic desensitization, which involves helping you to gradually become more comfortable with situations that frighten you.
The exposure process often involves 3 stages:
- The first stage involves introducing you to the feared situation.
- The second stage is to increase the risk for disapproval in that situation. This builds your confidence that you can handle rejection or criticism.
- The third stage involves learning techniques to cope with disapproval. In this stage, you imagine your worst fears and are encouraged to develop constructive responses to those fears.
Cognitive behavior therapy for social anxiety disorder also includes anxiety management training—teaching you techniques such as deep breathing, relaxation exercises, or meditation to help control your level of anxiety. Another important aspect of treatment is called cognitive restructuring, which will help you to identify unrealistic thoughts and develop more realistic expectations about the likelihood of danger in social situations. The duration of this treatment varies from 1-4 months. Approximately 50% of people show symptomatic improvement.
Other Types of Therapy
You can also benefit from supportive therapy, such as group therapy, which helps you learn how to interact comfortably with other people. Couples or family therapy can help to educate your significant others about the disorder. You may also benefit from social skills training.
The idea behind this type of psychotherapy is that symptoms of social anxiety disorder may be the result of mental processes which the patient is not aware of. The mental health clinician could help to clarify these mental processes, thus relieving symptoms. The duration of treatment is approximately 12 weeks.
Any program to relieve stress and anxiety (such as yoga, meditation, exercise, hypnosis, learning to delegate work) and assertiveness training will help to relieve the anxiety that is felt in various social situations. These stressing relief techniques could be added to cognitive behavioral therapy.
Revision Information
- Reviewer: EBSCO Medical Review Board Adrian Preda, MD
- Review Date: 06/2017 -
- Update Date: 12/20/2014 -


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Beloit professor explores issue of U.S. drone strikes
BELOIT--Missiles fired by a U.S. drone slammed into a group of vehicles traveling to a wedding party in Yemen last month.
A U.S. official said the intended targets were al Qaeda militants, and up to 14 were killed.
It was unclear whether any militants were traveling with the wedding convoy, the Associated Press reported.
But the incident is one of the most recent to raise questions about U.S. drone strikes.
Beth Dougherty of Beloit College wants to raise awareness about the issue.
The professor of political science will talk about the use of drones for targeted killing in a public talk Wednesday on the Beloit College campus.
"The U.S. argues that drone strikes are the most effective counter-terrorism tool that we have," she said. "I'll be looking at the different pieces of that argument and evaluating them."
Dougherty teaches courses in international politics, including Middle Eastern politics, human rights and U.S. foreign policy.
"The most important claim about drones is that they kill terrorists and minimize civilian casualties," Dougherty said. "But it's difficult to evaluate the claim. One of the biggest problems about drone strikes is that we don't have good information about who is killed."
In the aftermath of a drone strike, normally the press or the U.S. military would report on the outcome.
But many strikes occur in remote areas where there is no press coverage or no U.S. military.
"What you get are two conflicting claims," Dougherty said. "The U.S. argues that drones are very precise, and we are only killing terrorists. The other side says civilians are killed. A respected human rights organization released a report two months ago saying scores of civilians have died in drone strikes."
Dougherty referred to a Human Rights Watch report, released in October.
Prior to the attacks of Sept. 11, the United States opposed the use of drones for targeted killing.
"But after 9/11, the government embraced the idea," Dougherty said. "Later, (former President George W.) Bush ordered the arming of drones. The use of armed drones is a direct result of the 9/11 attack."
President Obama continues to use armed drones.
"It is not a partisan question," Dougherty said. "Both administrations have used the same arguments and the same tools against terrorism. There's the whole question of whether the U.S. is killing civilians without cause."
Civilian deaths have bred resentment, sometimes undermining U.S. efforts to turn the public against the militants, she said.
"It clearly has increased anti-American sentiment overseas," she said, "particularly in places that we consider important in terms of battling radicalism, including Pakistan and Yemen. In the long run, the use of drones may be a counterproductive strategy."
Dougherty said the United States is setting precedent for future use.
"What rules do we want China or Russia to follow, for example, when they have drones?" she asked. "What if China started using drones to take out the leadership of the Tibetan freedom movement in exile?"
Lack of information makes it hard to evaluate the drone program, she said.
"We do not know how many drone strikes have been carried out or how many citizens have been killed," Dougherty said. "The administration is operating at an extraordinary degree of secrecy. The question is: Do we want the executive to carry out targeted killings with no oversight and no public scrutiny?"
Anna Marie Lux is a columnist for The Gazette. Her columns run Sundays, Tuesdays and Thursdays. Call her with ideas or comments at (608) 755-8264, or email email@example.com.


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How to get best use from step-down voltage regulator
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Increases in digital IC integration, coupled with advances in printed circuit board layout and assembly techniques, continue to push system performance and power density higher. Many of these systems, powered from a 12V rail or battery stack, utilize point-of-load regulators to maximize power chain efficiency while maintaining a small form factor. The LTC3626 synchronous, monolithic step-down regulator is suited for these operating environments, given its ability to provide a flexible DC/DC conversion while occupying a very small footprint.
The LTC3626 can supply 2.5A of output current over an input voltage range of 3.6V to 20V from a 3mm × 4mm, 20-pin QFN package. Its patented controlled on-time architecture yields outstanding transient response and enables high step-down ratios at high switching frequencies, minimizing board footprint.
The LTC3626 integrates easy-to-use features that would normally require additional ICs and design time to implement. Specifically, with the addition of just a couple of passive components, the LTC3626 can be configured to provide accurate measures of its output current, input current, and on-die temperature. It can be just as easily programmed to limit each measured parameter.
These built-in features expand the designers insight into the performance of the system and increase the level of control with remarkably little extra design investment. Additionally, optional internal loop compensation is available to minimize the design effort.
The LTC3626 also includes user-selectable Burst Mode operation or forced-continuous mode, resistor-programmable switching frequencies from 500kHz to 3MHz, power good status output, output tracking capability, and external clock synchronization.
Current monitor and limit
One way to measure the overall performance of a system is to monitor the current at the output of the power supply. Supply current monitoring also informs designers if downstream ICs are operating as expecteduseful in design and debug, and during normal operation.
The LTC3626 enables to monitor the supply current by producing a fraction of its average output current at its IMONOUT pin; specifically, the current at the IMONOUT pin is equal to the average output current divided by 16,000.
Figure 1 shows the typical performance of the output current measurement for an ambient temperature range of 40°C to 85°C. Figure 2 shows the error between the actual average output current and the average output current as measured by the LTC3626.
The current at the IMONOUT pin can be measured directly or converted to a voltage by placing a resistor from the IMONOUT pin to ground. Converting the output of the IMONOUT pin to a voltage makes it easy to scale the output for digitization via a microcontroller or stand-alone ADC. Figure 3 shows the LTC3626 configured to run with the output current monitor activated while the LTC2460, 16-bit ADC, digitizes the result for digital processing.
Click on image to enlarge
The LTC3626 also features an easily programmed average output current limit. Specifically, the LTC3626 contains an on-chip current limit amplifier with a reference of approximately 1.2V. To program an average output current, simply size the resistor from IMONOUT to ground such that the resultant voltage is 1.2V for the current at which the limit should be activated.
Similar to the average output current, the LTC3626 produces an estimate of the average input current at the IMONIN pin. That is, the current at the IMONIN pin is an estimate of the average input current divided by 16,000. Just like the average output current, the LTC3626 offers a simple mechanism to program a limit for the average input current. This feature is useful for applications that must limit the average current drawn from the input supply. Figure 4 shows the LTC3626 configured to limit the average input current to 475mA while producing an output voltage of 2.5V from a 5V input voltage.
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Commercial Club Playground
1845 W. Rice St. Chicago, Illinois 60622
(312) 742-7558
Fee: Free
Age Range: All ages
This Earth Day celebration will include cleaning up the park and playground areas. Join the fun and then enjoy a free volunteer lunch following the clean up. Event will be held come rain or sunshine!


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Hormonal Contraceptive Agents/Telaprevir Interactions
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Medical warning:
Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
How this interaction occurs is not known.
What might happen:
Hormonal contraceptive products (such as "the pill", the "mini-pill", Norplant, birth control injections, and the patch) may not prevent you from becoming pregnant while you are taking telaprevir. Telaprevir is used with another medicine, ribavirin, which may cause birth defects.
What you should do about this interaction:
You should not rely on a hormonal contraceptive agent as your method of birth control while taking telaprevir. Discuss birth control options with the doctor that prescribed telaprevir for you and with your gynecologist (OB/GYN). You should use two other methods of birth control (such as an intrauterine device [IUD] and/or barrier methods) while taking telaprevir and ribavirin and for six months after finishing your therapy. Be sure to undergo a pregnancy test every month. If you think that you may be pregnant, contact your doctor right away.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
- 1.Incivek (telaprevir) US prescribing information. Vertex Pharmaceuticals Incorporated October, 2013.
- 2.Garg V, van Heeswijk R, Yang Y, Kauffman R, Smith F, Adda N. The Pharmacokinetic Interaction Between an Oral Contraceptive Containing Ethinyl Estradiol and Norethindrone and the HCV Protease Inhibitor Telaprevir. J Clin Pharmacol 2011 Oct 30.


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Mibefradil/Selected Agents Interactions
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Medical warning:
Severe. These medicines may interact and cause very harmful effects and are usually not taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
When these two medicines are taken together, your body may not process cholesterol medicines properly.
What might happen:
Your blood levels of cholesterol medicine may increase and cause muscle pain or flu-like symptoms.
What you should do about this interaction:
Contact your healthcare professionals (e.g. doctor or pharmacist) as soon as possible about taking these two medicines together. They may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
- 1.Dear Doctor Letter. Roche Pharmaceuticals December 1997. 2."Dear Doctor" letter on mibefradil. Roche Pharmaceuticals June 12, 1998. .


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New December 2011
Order copiesMX971, MyPlate: Eat Seafood Twice a Week — 10 Tips to Help You Eat More Seafood
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This series of tipsheets and a brochure help consumers make healthy food choices for their families. They promote MyPlate released by the United States Departments of Agriculture and Health and Human Services in June of 2011 to promote healthy food choices.
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Rangers' fate is tied to pitching
By Tracy Ringolsby / MLB.com
SURPRISE, Ariz. -- The Texas Rangers have lost their primary No. 3 hitter of the past five seasons, Josh Hamilton, and the middle-of-the-order impact bats of Michael Young and Mike Napoli.
Yep, about the rotation.
"I think we're going to score runs, and our defense is going to be good, so I just really think that it's going to come down to the pitching giving us an opportunity to win ballgames," Rangers president Nolan Ryan said.
There's reason for concern.
After back-to-back American League pennants in 2010-11, the Rangers had to settle for a Wild Card invite to the postseason last October, and they got knocked out in the one-game showdown against the Baltimore Orioles.
They led the Major Leagues with 808 runs scored last year, and ranked second to only the Yankees with a .780 OPS. They, however, ranked 16th in the big leagues with a 3.99 ERA in a season filled with pitching uncertainty.
Ryan does not deny the impact of Hamilton, who parlayed free agency into a five-year, $125 million deal with the AL West-rival Los Angeles Angels of Anaheim.
"I think the day Josh signed, I think the pucker factor went up considerably," said Ryan of the reaction in the Rangers front office.
Ryan, however, felt Rangers general manager Jon Daniels and his staff handled that challenge well, signing Lance Berkman to take over at the DH spot, and A.J. Pierzynski to assume the primary-catching chores, while opting to give Craig Gentry, the fourth outfielder a year ago, an everyday chance in center with 2011 Cuba defector Leonys Martin lurking.
"I think our baseball guys took a step back and said, 'All right, what we formulated going into the offseason hasn't materialized so we need to step back, look at the landscape and figure out what we can do to improve our ballclub,'" said Ryan.
There, however, is still that looming concern about the pitching staff.
Matt Harrison, with 32 starts, was the only member of the rotation to make as many as 30 starts last year. Yu Darvish started 29 games, and Derek Holland 27. The Rangers used 11 different pitchers in the rotation, and the pain was felt early.
Worst fears on the attempt to move Neftali Feliz out of the bullpen to the rotation were fulfilled. Eight appearances, seven starts, into the season and Feliz was done on May 18. He underwent Tommy John surgery on Aug. 1. It's usually at least a year recovery, and when he does return the cautious faction figures to win out and Feliz will return to the bullpen. Holland was victimized by a stomach virus that limited him to no starts in June. Colby Lewis underwent season-ending elbow surgery in July, and could be out the first two months this season.
So where do the Rangers turn?
Well, they do have Harrison and Darvish.
Then there is the hold-your-breath duo of Holland -- who they hope has taken a step up in maturity after an offseason chat with Ryan -- and Alexi Ogando -- whose lack of an offspeed weapon saw him back in the bullpen last year following a second-half fade as a starter in 2011.
"With Ogando, we're going off what he did two years ago as a starter, and you hope that he'll show the consistency that he had the first part of the [2011] season, and that he'll hold up over the course of the year. With Derek, the area of concern is the fact of his inconsistencies. So, yeah, both of those guys are going to need to take their game to another level."
And then ...
"We've got to find a fifth starter and then obviously fill some places in the bullpen," said Ryan. "I think, obviously, we're going to hope that one of the young kids steps up and fills some of the needs that we have."
Part of the challenge for the Rangers is balancing the urgency of the moment with the long-range picture. If Lewis really does return in six weeks or so, how much do they really want to invest in acquiring a starter? So the Rangers are willing to spend the spring auditioning. Martin Perez is a hot topic, but he did not distinguish himself in a 12-game big league audition last year that included six starts.
The Rangers brought veterans Kyle McClellan and Randy Wells to camp as non-roster invitees. Justin Grimm has only two years in pro ball but did get a late-season audition in Arlington last season. And as Ryan assessed the situation, the impression was left that the door is open for Robbie Ross, who moved into the bullpen last year.
"All of us feel that Martin Perez is a very talented kid who has three pitches, and when we start talking about a spot in the rotation, really what you look for is somebody that has that," said Ryan. "The thing I hope to see out of him is consistency. I think for him to earn that spot, that's what he's going to have to do, show some consistency. When you look at what Robbie Ross did last year, his outings in Spring Training were pretty darn consistent and that's what you hope that whoever wins that spot -- I have a feeling that's what's going to be a separator."
At least he hopes it is.
Oakland showed what a strong-armed staff can do when it knocked off Texas to claim the AL West a year ago.
Ryan and the Rangers are looking to call the A's hand this time around.
Their success depends on how the arms develop this spring.
Tracy Ringolsby is a columnist for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.


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A basic short sleeve tee with an on-trend dream catcher graphic.
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Tropical North Queensland fits in more untouched beauty, ancient culture and adventure within its borders than some entire countries manage to do, with the World Heritage-listed double-act of the Great Barrier Reef and Wet Tropics Rainforest its most prized stars.
Cairns & the Great Barrier Reef is total bucket list material.
If you're seeking a real connection to the land, you'll find it in the stories, the smiles and the history of the Indigenous Australians who share their culture with you.
While Palm Cove, Cairns and Port Douglas are the main ports of call, your holiday here among the palm trees is just the beginning.


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Terms and Conditions for The Gymboree Corporation's Factories
The Gymboree Corporation is all about celebrating childhood. We're passionate about supporting the development of happy, healthy kids and this is at the heart of everything we do.
We uphold requirements for all of our factories in order to do business with us. These factories are audited on a regular basis to ensure their compliance with our terms, which include the prohibition of child labor or forced labor, treating workers with respect and without discrimination, and ensuring fair wages and a safe work environment. We prohibit the use of cotton sourced from Uzbekistan and textiles produced using Uzbekistan cotton because of Uzbekistan's history of forced child labor.
We are committed to making a difference inside and outside of our company, and this begins with giving kids a chance to be kids and producing quality products that make us proud.
To learn more about The Gymboree Corporation's requirements for suppliers and factories, the following summarizes our Terms & Conditions:
The Gymboree Corporation is committed to sourcing its products in compliance with applicable laws. While Gymboree understands that there are many different legal and cultural differences in factories which operate throughout the world, Gymboree establishes minimum requirements for all of its factories in order to do business with Gymboree. Gymboree regularly audits the factories to ensure their compliance with the law and the minimum requirements listed below.
1. Compliance with the Law: All of Gymboree's factories shall operate in full compliance with all applicable laws, rules and regulations, including, but not limited to, those related to labor, worker health, safety and environment.
2. Child labor: Gymboree factories shall not employ any children. The term "child" means a person who is less than 15 years old or younger than the age for completing compulsory education in the country of manufacture where such age is higher than 15. Factories are encouraged to develop lawful workplace apprenticeship programs whenever possible for the educational benefit of their workers, provided that all participants meet both our minimum age standard of 15 and minimum legal age requirements. Gymboree prohibits the use of cotton sourced from Uzbekistan and textiles produced using Uzbekistan cotton because of Uzbekistan's history of forced child labor.
3. Forced or prison labor: Gymboree's factories shall not use any forced, prison or indentured labor in the manufacture and finishing of our products. Furthermore, Gymboree does not tolerate the use of corporal punishment.
4. Non-discrimination: Gymboree requires that all of our factories employ workers on the basis of their ability to do the job, without regard to their personal characteristics or beliefs. Gymboree recognizes and respects cultural differences from country to country and will favor those factories that are sensitive to these differences.
5. Wages, benefits and hours: Gymboree requires its factories to set working hours, wages and overtime pay in compliance with all applicable laws, rules and regulations. All workers shall be paid at least the minimum legal wage or a wage that meets local industry standards, whichever is greater. While Gymboree favors factories who utilize less than sixty hour work weeks, it is understood that overtime is often required in garment production. Therefore, Gymboree requires its factories to operate in ways that limit overtime to a level that ensures humane and productive working conditions.
6. Working conditions: Gymboree expects all of its factories to treat all workers with respect and dignity and not to exploit them in any way. Gymboree also expects all of its factories to provide their workers with a safe and healthy work environment.
7. Monitoring, evaluation and enforcement: As a condition of doing business with Gymboree, each and every factory must comply with these Terms and Conditions. Gymboree has systems in place to assess and monitor compliance. If Gymboree has determined that any factory has violated any of these Terms and Conditions, we will either terminate our business relationship with that factory or require the factory to implement a corrective action plan. If corrective action is advised but not taken by a particular factory, Gymboree will suspend placement of future orders and may terminate current production at that factory.
8. Gymboree�s Accessibility Policy and Multi-Year Accessibility Plan
This 2014-2021 Accessibility Plan (�Plan�) outlines the policies and actions that The Gymboree Corporation (�Gymboree�) will put in place to improve opportunities for persons with disabilities in its store locations in Ontario, Canada. This Plan outlines how Gymboree intends to meet the requirements of the Integrated Accessibility Standards Regulation made under the Accessibility for Ontarians with Disabilities Act (the �AODA�).
Gymboree is dedicated to providing goods, services and employment in an accessible manner and is committed to treating all people in a way that allows them to maintain their dignity and independence. We believe in integration and equal opportunity. We are committed to meeting the reasonable accessibility needs of persons with disabilities in a timely manner, and will do so by preventing and removing barriers to accessibility and meeting accessibility requirements under the AODA.
This Plan is a fluid document that will be revised at least once every five years to reflect changes in Gymboree�s accessibility strategies. Gymboree welcomes feedback regarding this Plan, in whichever format is most convenient to the person giving feedback. If the Plan states that a document or information is available upon request, such requests should be made by phoning Gymboree�s Customer Service number at 1 (877) 449-6932 or by sending an e-mail to email@example.com.
Individualized Emergency Preparedness Plan
Gymboree will develop individualized emergency preparedness plans as required and as soon as practicable, for employees who Gymboree is aware require assistance in emergency situations.
Gymboree will provide training to employees, volunteers and other staff members on Ontario�s accessibility laws and on the Human Rights Code as it relates to persons with disabilities. Training will be provided in a way that best suits the duties of employees, volunteers and other staff members.
Gymboree will ensure that employees are provided with the training needed to meet Ontario�s accessibility laws by January 1, 2015. Gymboree will maintain records to confirm that each employee, volunteer and staff member has read and completed the training materials.
The training will cover the objectives of the AODA and how to interact, communicate and support persons with disabilities in light of their disability. After January 1, 2015, the training will be conducted as needed, in order to inform individuals of changes to Gymboree�s procedures and policies in delivering goods or services to persons with disabilities. If newly hired, the individual will receive training as soon as practicable. The training delivered will instruct employees, volunteers and other staff members on the following:
� Persons with disabilities may use their own assistive devices when visiting Gymboree.
� Persons accompanied by a guide dog or service animal are permitted to enter our premises with the animal, except in areas in which the animal is excluded by law.
� When a person with a disability is accompanied by a support person, both the person with the disability and the support person are permitted to enter together and have equal access to Gymboree�s premises.
� Gymboree will provide notice to the public of any temporary disruptions to facilities or services offered by Gymboree and used by persons with disabilities. This notice will include the reason for the disruption, the anticipated length of the disruption and a description of any alternative facilities and/or services that are available.
� The Plan is available at www.gymboree.com.
Point-of-Sale Devices and Service Counters
Gymboree will consider the accessibility of electronic terminals when designing, procuring or acquiring self-service kiosks including point-of-sale devices. Gymboree will consider the various needs of persons with disabilities prior to making any decisions regarding the purchase, implementation and use of self-service kiosks.
By January 1, 2017, Gymboree will ensure that when constructing new service counters (or replacing existing service counters), there will be at least one service counter that reasonably accommodates a mobility aid. This service counter will be clearly identified and will:
� Be at a height such that it is usable seated in a mobility aid;
� Have sufficient knee clearance for a person seated in a mobility aid; and
� Have sufficient floor space in front of the counter to accommodate a mobility aid.
If applicable, by January 1, 2017, when constructing new fixed queuing guides, Gymboree will ensure that the fixed queuing guides have sufficient width and floor area to allow for the passage of mobility assistive devices and are cane detectable. Gymboree will have procedures for preventative and emergency maintenance of accessible elements and for dealing with temporary disruptions when accessible elements are not in working order.
Accessible Websites and Web Content
� Gymboree is committed to meeting the communication needs of persons with disabilities. By January 1, 2016, Gymboree will, upon request, consult with persons with a disability in order to provide and arrange for the provision of accessible formats and communication supports.
� Gymboree will take steps to ensure that all new websites and website content conform with the Worldwide Web Consortium�s Web Content Accessibility Guidelines (WCAG 2.0) at Level A.
� By January 1, 2021, Gymboree�s internet websites and web content will conform with WCAG 2.0 Level AA.
Feedback, Accessible Formats and Communication Supports
� Gymboree will accept feedback in person at retail locations, by phoning our Customer Service number at 1-877-449-6932, by emailing us at email@example.com or by writing to us at Gymboree Customer Service, 2299 Kids Way, Dixon, CA 95620.
� Gymboree will ensure that, by January 1, 2015, it has the processes in place for receiving and responding to feedback that are accessible to persons with disabilities.
� By January 1, 2016, and upon request, Gymboree will provide or arrange for accessible formats and communication supports that suit for persons with a disability, at no extra cost and in a timely manner. Requesting persons we be consulted as to the suitability of an accessible format or communication support.
� By January 1, 2016, Gymboree will notify the public about the availability of accessible formats and communication supports.
Gymboree is committed to fair and accessible employment practices. By January 1, 2016, accessibility will be integrated into Gymboree�s employment-related practices throughout the employment life cycle, as set out in more detail in this section. Gymboree will take the following steps to notify the public and staff that, when requested, they will provide reasonable accommodations to persons with disabilities during the recruitment and assessment processes, and after individuals are hired.
Recruitment By January 1, 2016: � Existing recruitment, assessment and selection processes, material and procedures will be reviewed and modified by Human Resource staff as is necessary. � The public and any job applicants will be notified that Gymboree will provide reasonable accommodations to persons with disabilities upon request. The fact that reasonable accommodation is available will be specified in recruitment-related materials.
� In the event an applicant requests some form of accommodation, Gymboree will consult with the applicant and ensure that reasonable accommodations are made that take into consideration the applicant�s disability needs.
� When Gymboree is making an offer of employment, it will notify the successful candidate of the policies in place to provide reasonable accommodation to employees.
Gymboree will develop and update individualized emergency preparedness plans as soon as practicable, for employees who Gymboree is aware require assistance in emergency situations.
By January 1, 2016:
� Existing orientation and on-boarding procedures will be reviewed and modified to reflect Gymboree�s accessibility policies. This ensures that when employees begin employment, they are aware of the accommodation policies in place for persons with disabilities.
� A procedure will be established to inform colleagues of any changes made to accommodation policies in place at Gymboree.
Return to Work from Disability-Related Leaves
By January 1, 2016:
� Gymboree will modify and review existing return to work procedures for persons that have been absent from work because of a disability and are now in need of accommodation upon returning to the workplace. When a person with a disability returns to work, Gymboree will work with that person to create an individual plan that provides reasonable accommodation.
� Training will be put in place for managers and their colleagues who oversee the return to work process for persons who require accommodation.
Performance Management, Career Development and Redeployment
By January 1, 2016:
� Gymboree will modify and review career development, performance management and redeployment processes, as applicable, to take into consideration individual accommodation plans and the accessibility needs of persons with disabilities.
� Training will be put in place for managers and their colleagues who oversee career development, performance management and redeployment procedures.
For More Information
For more information on this Plan, please contact: Gymboree�s Customer Service department:
� Phone: 1-877-449-6932
� Email: firstname.lastname@example.com
� Mail: 2299 Kids Way, Dixon, CA 95620
Information in Response to the California Transparency Act.
Information regarding Conflict Minerals.


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Garfield Park Conservatory
300 N. Central Park Ave. Chicago, Illinois 60624
(773) 638-1766
Fee: Free
Age Range: Any
Enjoy a morning of Chicago's best music, dance, or theater in a kid-friendly setting with Juicebox. Juice box is a free series of cutting edge performances, Juicebox is geared at toddlers but is engaging for the whole family. Kids can sit on the floor, walk around, meet the artists, and sometimes even play with the instruments and puppets. BYO snacks are welcome too!The first performance begins Saturday, April 13 and every other Saturday through the end of the year at various locations. Click on link for more information and the full schedule: http://www.cityofchicago.org/city/en/depts/dca/supp_info/juicebox.html


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Euro-area government bonds surged, led by Italian and Spanish securities, after the European Central Bank (ECB) unexpectedly cut its benchmark interest rate to a record low, boosting demand for fixed-income assets.
Italy's two-year yield fell to the lowest level in more than five months, while the rate on Germany's two-year notes dropped to the least since May. The ECB reduced the main refinancing rate by 25 basis points to 0.25 percent. The decision was forecast by three out of 70 economists in Bloomberg News survey, with the remainder predicting no change. ECB President Mario Draghi, speaking to reporters in Frankfurt, said weaker growth is a downside risk to inflation.
"The euro region is likely to get stuck in a low-growth, low-inflation environment for a while," said Harvinder Sian, a fixed-income strategist at Royal Bank of Scotland Group Plc in London. "For the ECB's easing bias to have any meaningful credibility at all, it has to act. And it did."
Italy's 10-year yield fell nine basis points, or 0.09 percentage point, to 4.12 percent at 3:40 p.m. London time after reaching 4.04 percent, the least since May 28. The 4.5 percent bond maturing in March 2024 rose 0.765, or 7.65 euros per 1,000-euro ($1,337) face amount, to 103.525. Italian two-year yields fell as much as 18 basis points to 1.24 percent, the lowest since May 20.
Spain's 10-year yield fell eight basis points to 4.07 percent, the biggest fall since Oct. 22. The rate on the nation's two-year notes dropped eight basis points to 1.45 percent.
Inflation Slows
Data released on Oct. 31 showed the annual inflation rate in the 17-nation currency bloc fell to 0.7 percent, the lowest since November 2009.
The ECB now has just one more quarter-point cut left before reaching zero, increasing the likelihood of unconventional tools such as quantitative easing or a negative deposit rate if prices slow further or the economic recovery stalls. Euro-area inflation is less than half the ECB's 2 percent target, and unemployment is at the highest level since the currency bloc was formed in 1999.
The ECB kept its deposit rate at zero and trimmed the marginal lending rate to 0.75 percent.
Pledging to keep borrowing costs low for an "extended period," Draghi said weakening price pressures justified the ECB's surprise decision to cut its main interest rate.
"We may experience a prolonged period of low inflation," Draghi told reporters after the central-bank decision.
The additional yield, or spread, investors demand for holding Italian 10-year bonds vs. their German equivalents narrowed four basis points to 242 basis points after dropping to 236 basis points, the least since Oct. 24. Spain's 10-year yield spread over Germany tightened three basis points to 238 basis points.
"The strong gain in peripheral bonds today reflects a market theme that looser policy and more liquidity will benefit countries like Italy and Spain more than core countries like Germany," said Lyn Graham-Taylor, a fixed-income strategist at Rabobank International in London. "We expect the yield spread tightening trend to continue."
Spain sold 1.14 billion euros of 10-year securities today at the lowest auction yield in more than three years. The Madrid-based Treasury allotted the 2023 bonds at an average yield of 4.164 percent, compared with 4.269 percent at a previous sale on Oct. 3. Investors bid for 2.57 times the amount of debt on offer versus 1.96 times in October.
Unlimited Cash
Draghi said that the central bank will extend its unlimited offerings of one-month and three-month cash until the middle of 2015.
"We continue to monitor closely money market conditions and their potential impact on our monetary policy stance," Draghi said. "We are ready to consider all available instruments."
Germany's 10-year yield fell five basis points to 1.69 percent. The two-year rate dropped five basis points to 0.09 percent after declining to 0.05 percent, the least since May 31.
The German 10-year break-even rate dropped three basis points 1.54 percentage points, matching the lowest since June 25, based on closing prices. The rate, a gauge of inflation expectations, is derived from the yield difference between bunds and index-linked securities.
Five-year inflation swap rates, a market gauge of price- growth expectations over that period, declined to 1.34 percent on Nov. 1. That's within one basis point of the level reached in June last year, which was the lowest since December 2008. The rate slid two basis points to 1.37 percent today.
The implied yield on Euribor contracts expiring in December 2014, a measure of the outlook for three-month money-market rates, fell seven basis points to 0.345 percent, after dropping to 0.27 percent.
Italian securities gained 6.4 percent this year through yesterday, according to Bloomberg World Bond Indexes. Spain's returned 11 percent, while Germany's lost 1.3 percent.


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Theories - Origin of Life
Discussion of everything related to the Theory of Evolution.
Moderator: BioTeam
Re: Theories - Origin of Life
Thanks for the very considered and obviously very honest post.
Your philosophical approach to this matter serves only to re enforce my contention that macro evolutionary theory is essential a philosophical explanation for the origin of species. It is a pity that others who have presented their views, and in many cases so belligerently, cannot appreciate that this naturalistic approach is a philosophical one.
Origin of species is by nature a historical science, and since none of us were there at it's inception all evidence must be defined as circumstantial.
The question therefore is not to do with the evidence itself, but to what origin that evidence is actually pointing.
My argument is simply that the evidence points away from a naturalistic origin and towards design by an outside agency.
The proof of concept of this view has been adequately demonstrated by Craig Venter and his team.
Their minds were directing an intentional design and manufacture. The product being a new species. So I do have verifiable data on my side.
My contention therefore is not based on a preconceived philosophy, but on pretty solid science.
The only question that remains is whether the mind(s) involved reside in a physical brain or in some other non-material dimension.
This would not take such a leap of imagination (or faith) as you perhaps suggest.
Theoretical physicists have been developing theories around 10 and 11 dimensions for some time now. String and M theory are perhaps the more prominent ones.
If I have been, I can assure you it was not intentional, although I accept it may have come over that way.
Re: Theories - Origin of Life
Very interesting thoughts.
Let me move forward on your comment
In the past I have deliberately refrained from dealing with this "Ace up ones's sleeve" other than simply dismissing it as a desperate attempt to gain some credibility.
However you have understandably given it some credence so I will deal with it.
The who "designed the designer" argument centers on the concept of spacetime.
This is the 4th dimension our universe exists in and therefore clearly and logically a designer and creator of this universe must by any reasoning exist outside time and space.
So questions about who or what came before the designer simply lacks any scientific weight or credibility and stems from a lack of understanding of the nature of the natural world.
If time along with the other dimensions are products of design, then by simple logic they cannot govern the designer.
This logic is carried through in General Relativity. It is meaningless to talk about space and time outside the limits of the universe. ( Stephen Hawkins " A brief History of time Chapter 3)
Scientifically the question therefore is simply invalid and as I understand it, you have perhaps alluded to this yourself.
The question of who or what the designer may or may not be is not one that can be answered by science. Additional supporting evidence is required.
Only some form of evidence based historical documentation can begin to answer this question.
so you have problem to believe in evolution, because you lack evidence for it, but you have no problem to believe in god (and yes, your creator as you described it now, is nothing else than god of any religion), although you have no evidence for its existence?
Cis or trans? That's what matters.
Re: Theories - Origin of Life
JackBean, the physical evidence for the creator's existence is although circumstantial, but it goes beyond the realm of Biology, and it's substantial enough to be just dismissed (the anthropic coincidences, for instance, and attempts to get out of them with "multiverse" ideas etc..)
Scottie, thank you for your reply. One point… Stuff like that M-theory "mambo jumbo" led me to conclusion that the line between what we call "naturalistic" and "supernatural" is quite illusive. When a professor of physics seriously talks about possible communication with residents of other dimensions with a help of "gravitons" …. well what is natural and what is supernatural then? Supernatural, the way I see it, might as well be absolutely natural, just sitting on the other end of the abyss of still unknown. A flying piece of aluminum would be considered absolutely supernatural thing many centuries ago simply because a gap between cave level of knowledge and Bernoulli's principle was too big back then.
The 4th dimension, as described by Einstein, is time, not another space dimension. Also, you can not simply say that "X is possible", physical evidence rather than theoretical derivation is required to say that "X must be true" when dealing with subjects as extraneous as this.
Re: Theories - Origin of Life
Scottie, you have problem understanding why this question is asked to you. It has absolutely nothing to do with Einstein or relativity and everything to do with logic and standard used for you to judge the acceptability of an hypothesis, i.e. to demonstrate a case of double standards.
You are basically refuting the theory of probability because you deem improbable that self-organisation can lead to complexity. Yet you accept that the probability that something that can create the complexity we are observing (and hence according to your own explanation must be more complex than us, and I would agree with you on that: we sure cannot create artificial life yet, Venter still needed a cell to kickstart his artificial genome) is on the other hand completely within acceptable limits. And I must say that it is not a very credible argument.
So unless you can give a better explanation on how an improbably complex and undetectable entity is more likely and acceptable than the current theory of evolution, you will just appear as a self deluded man who cannot make a self coherent argument to save the life of his discussion....
Science has proof without any certainty. Creationists have certainty without
any proof. (Ashley Montague)
Re: Theories - Origin of Life
Canalon, I think you have a problem understanding that you are asking a gigantic cosmological question, while preferring to stay within the relative safety of the pixel of Darwinian evolution theory (and all its assumptions). Life has not started with evolution; life has started 13.ish billion years ago with a Big Bang (so, apparently, Einstein is as relevant to the issue as Darwin). What we have now is "Boeing 747"; what we had at the beginning was ….. no, not even scraps, but the hydrogen molecules and the "hurricane going through them". We're not the result of the order and complexity, which arose by chance alone from the pre-evolution chaos and simplicity, but we are the consequence of the preexisting order and complexity imbedded in the laws of physics and chemistry, which appeared in the very beginning of it all on universal scale.
Every character in this game takes the rules it's based on as given, even though, in reality, NOBODY knows the number of possible messy outcomes the Big Bang could've produced, which would've resulted in different laws of physics, little (or no) number of stars, different (or no) periodic table and NO alive characters present and observing that mess of any kind. What I'm trying to say is that the fact that we're around, thinking, appreciating harmony and beauty, splitting atoms and writing poetry and it all started with a bunch of hydrogen molecules and the materialized-out-of-the-blue laws of nature is truly amazing (and I believe that every planet with earthlike conditions has the same development going on). No chance alone can be held responsible for it that lightly. You can dance around the roulette table as much as you want, but you will never become a rich man out of it – there is no way to avoid this statistical fact, simply because the preset rules of this "game of chance" favor a casino, not you. Only if you tilt the roulette table (even by 1 mm), the pattern you can bet on will eventually emerge. And as far as biological life goes, that tilt was quite substantial. And again… from the very beginning of our universe.
To make a long story short…. Without seeing beyond our universe in time and space, how can you objectively conclude that the post-Big Bang rules, thanks to which you exist, are the result of the "s*&t happens" or of the intelligent effort? As a character limited by this event horizon, how can you even objectively quantify which of these 2 causes of it all has a higher probability of happening without applying your pre-event horizon subjective logic to it? Don't you agree that simplicity first, complexity second is your subjective point of view, not more not less?
Re: Theories - Origin of Life
Sorry I have been away for a few days and only now just catching up.
I will respond this evening.
Re: Theories - Origin of Life
Sure but beyond the long words you have to admit that if you want to exclude evolution based on probabilities, you cannot accept an intelligent effort which is similarly improbable. So you have to provide positive evidence of an intelligence beyond life, which for the moment I have failed to see. All we have been presented with are along the line of "evolution is improbable, hence there must be a creator".
So my problem is not one of inscrutable cosmology, it is one of establishing a single standard of acceptability for a theory that could explain life as we know it. One standard that would be equally applicable to creation and evolution. One standard that requires positive evidence for something, rather than if it is not A, it must be B without any other support for B.
Science has proof without any certainty. Creationists have certainty without
any proof. (Ashley Montague)
Re: Theories - Origin of Life
With respect your comment suggests you don't appear to have a grasp of General Relativity, and how it is different from Newtonian physics. - a common confusion.
GR provides a framework under which the laws of physics look the same for everyone at every moment, regardless of how they are moving. Einstein, in his theory achieved this by making gravity a property of the universe, rather than of individual bodies, as does Newtonian Physics.
In other words in GR gravity is not what one body does directly to another, but what a body's mass does to the surrounding universe
So General relativity describes gravity as geometry.
The fabric of the universe is described as the four dimensions of space and time.(spacetime) This fabric which includes time, is full of lumps and bumps that is created by the presence of mass and energy.
The warping of this fabric is unavoidable whenever anything, be it you, me, a piece of space dust or a planet or even a photon of light tries to travel through the universe in a straight line, it actually follows a trajectory that is curved by any mass and energy in the vicinity. The result of this curvature is what we think of as gravity.
So when we refer to time, we are referring to a co-ordinate of this fabric, as are the other coordinates of length, breath and thickness. They don't exist separately.
That is why any question about time is meaningless if applied to any reality beyond this universe.
A common misconception is to think of GR in terms of Newtonian physics.
I don't wish to sound patronising but I will be happy to explain the difference in Newtonian gravity and GR gravity. The principles in Einstein's field equations are not too difficult to understand.
For the sake of clarity I will be happy do it in a separate post.
My whole argument is centered around the lack of physical evidence for macro evolution. As I understand it, you appear to support "evolutionary theory in whatever form" despite the lack of evidence that I have repeatedly pointed out in all the peer reviewed papers I have referred to.
So you now appear to be contradicting yourself.
If one (me) accepts the posit that an external agency designed and created the universe, then spacetime is by logic and theory a product of that design.
Therefore to posit an argument against this view by asking a question relating to time is, as I have stated, meaningless. Again this is not just my view but that of others much more informed than you or I.
You will therefore need to find another line of refutation.
I think we are on the same page. String and M theory are simply speculative theories that eminent scientists who cannot comes to terms with the fact that science does not have an answer to life/universe origins, have to somehow delve into the world of make believe science.
I refer to these theories to demonstrate the inconsistency of philosophical arguments parading as science. It is noticeable that the science I put forward is not refuted.
Why not?
Because it is a philosophy that is being promoted here not science.
That is why there has been so much heat.
Question the religion/philosophy of any fundamentalist idea and heat is what you get, as I keep finding out to my cost.
Evolutionary theory is a philosophy that even Ernst Mayr, one of the foundling fathers of the modern synthesis himself proudly acknowledged.
When you ask a question that has at it's root the dimension of time you have moved into the area of science that Einstein and many others have tried to address as legitimate lines of scientific research and theory. Please refer to my post to Aptitude above.
I understand only too well the demarcation lines between science and philosophy/religion, lines that you are desperately trying to blur.
The simple question is this.
Is macro evolutionary theory actually supported by evidence or is it simply your belief that it is.
Gavin was honest enough to acknowledge his philosophical approach.
Why are you finding it so hard to do the same?
After all science is not going to be the loser if you do, will it?
scottie, you are not that much on one page with Nick7, he's saying, that evolution is not related to the origin of species, while you're still arguing it is
The simple question is this.
Is intelligent design actually supported by evidence or is it simply your belief that it is.
Cis or trans? That's what matters.
Re: Theories - Origin of Life
JackBean, I think I was misunderstood a bit. I was not saying that evolution was not relevant to the origin of species. I was saying that any design-vs-randomness discussion about appearance of life will be impaired if it's focused on Biology / Genetics / Paleontology only. Complex life requires complex and orderly laws of nature as a prerequisite. Appearance of this order and complexity in the universe out of a pea size singularity is as peculiar (and relevant to the discussion) as abiogenesis, for instance. Abiogenesis (as puzzling as it is) requires a rich periodic table, periodic table requires thermonuclear fusion inside the stars (with very unique and rare events of its own, like triple-alpha process), stars formation requires sufficient amount of gravity …..going all the way to the very beginning, which also has a puzzling example of order (the cosmological "flatness problem"). So the way I see it, it's a legit possibility that the order and complexity observed in our world (biology, physics, cosmology, etc.) may denote intelligence.
Canalon, thank you for reply! About standard of acceptability (and to complete a thought in the reply to JackBean) … Digging up a prehistoric skeleton and using it to prove a hypothesis is fine, but pre-big-bang cosmological skeletons as well as the reasons behind the laws of nature hidden in the bizarre subquantum world are not immediately available. That's why I wouldn't expect Scottie to present a full-scale sufficient hypothesis in a classical understanding of this word at the moment, but I don't see a problem with occasional sophisticated poking of the current orthodoxy with a stick.
Scottie, about you getting the heat… I'm sure this section of the forum has seen its share of visitors telling stories about Adam and Eve prancing around together with brontosauruses. So the local old-timers have developed a powerful immune system killing on the spot anything that even moves into any suspicious directions. … I might be wrong, but I think your case is a collateral damage of that immune system.
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What should state do with "other people's money"?
�I got a chuckle out of the words of state Rep. Tyler August, R-Lake Geneva, in today's Gazette. The state is projecting a budget surplus of about $1 billion, and August is all for the tax relief plans that Gov. Scott Walker is expected to outline tonight in his fourth annual State of the State address.
"I think it is the people's money, and we should send it back to them," August said. The money must leave Madison ASAP because, August said, "culture up here is if we find some quarters in the couch, everyone wants to spend them right away."
That comment reminds me of a movie. Maybe you've seen the 1991 flick appropriately titled "Other People's Money" and starring Danny DeVito as the despicable Lawrence "Larry the Liquidator" Garfield. (Side note: My late namesake, Gregory Peck, also stars)
"I love money more than I love the things it can buy," Garfield says. "…Money, it don't care whether I'm good or not. It don't care whether I snore or not. It don't care which god I pray to. There are only three things in this world with that kind of unconditional acceptance: dogs, doughnuts and money. Only money is better. You know why? Because it don't make you fat and it don't poop all over the living room floor. There's only one thing I like better. Other people's money."
Setting aside the grammatical gaffes, Garfield sounds like the consummate politician, doesn't he? He loves to spend other people's money.
Should the state give half of the projected surplus back to residents in the form of tax cuts, as Walker reportedly will suggest? Should it invest more in education, as many Democrats propose? Should it spend more of it in transportation funding, put more in reserves or halt its habits of increasingly borrowing more money and using accounting tricks to "balance" its budget?
What else would you like to hear from Walker tonight?
In our editorial Thursday, The Gazette's editorial board will share its views on sensible uses for the projected surplus.
Greg Peck can be reached at (608) 755-8278 or email@example.com. Or follow him on Twitter or Facebook.
Greg Peck can be reached at (608) 755-8278 or firstname.lastname@example.com. Or follow him on Twitter or Facebook.


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GLPI (Gestion Libre de Parc Informatique) is an information resource manager with an administration interface. You can use it to build a database with an inventory for your company (computers, software, printers, etc.). It has functions to make the daily life of the administrators easier, including a job/request tracking system with mail notification and methods to build a database with basic information about your network topology. It provides a precise inventory of all the technical resources (all their characteristics are stored in a database) and management and history of the maintenance actions and the bound procedures. It is dynamic and is directly connected to the users, who can post requests to the technicians.
Kronolith is the Horde calendar application. It provides a stable and featureful individual calendar system with integrated collaboration and scheduling features. It makes extensive use of the Horde Framework to provide integration with other applications. It implements a solid, stand-alone calendar system, allowing repeating events, all-day events, custom fields, keywords, shared calendars, iCalendar support, generation of free/busy information, and managing multiple users through Horde Authentication.
XWiki is a WikiWiki clone written in Java that supports many popular features of other Wikis like the Wiki syntax, version control, attachments, security, and searching, but also many advanced features like templates, database and dynamic development using scripting languages (Velocity, Groovy, Ruby, Python, PHP, and more), an extension system and skinability, J2EE scalability, an XML/RPC remote API, statistics, RSS feeds, PDF exporting, WYSIWYG editing, an Office viewer and importer, and a lot more.
UAV ground control software.
An image processing component.