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Hello again everyone, boy, I'm turning into a regular around here :(
A couple of weeks ago I had a second miscarriage after 12 months of infertility. Yeah, I know, it sucks. You all know it sucks. So glad these boards exist so I feel a little less alone in all this while everyone around me has a baby no problem.
I've been seeing an RE who has me putting TTC on hold for the time being while they do some more diagnostic stuff.
I have had lots of diagnostics including a saline ultrasound and a zillion blood tests and they have found two potential problems.
1) something in my saline ultrasound looked like uterine scarring-- uterine synechiae is the official term. They are going to wait a month and look at it again, but if it is indeed scarring they will need to do a hysteroscopy to remove it. I'm a little freaked out as I've never had real surgery before (they'd need to put me "under", which scares me a bit). But what really worries me is that I am not seeing any literature that claims removing uterine scarring improves fertility. I am trained in public health, I know how to read medical research, and I am not seeing anything convincing on Pub Med. Does anyone know of any evidence that this is a legit thing that can solve infertility? I'll settle for anecdotal, even, if you know anything. And if any of you have had a hysteroscopy please let me know about it.
2) I also was found to be positive for MTHFR, two copies of the gene, the blood clotting genetic mutation. From my research it seems relatively harmless, but some REs suspect it can contribute to infertility and miscarriage especially when you have two copies of the gene. Again, same as above, I'm not finding any solid evidence of this anywhere. Does anyone know anything about MTHFR and miscarriage/infertility? I'd like to read up on this more before I discuss with my doctor further.
Thanks again everyone for being such a great resource. I am so grateful for this board and for all of you.
Happily married for 5 years. Tried for our first baby 6/2011, got preg right away, and miscarried. Took a 4 month break, and then had nothing but infertility & a few early miscarriages until 12/2012 when we learned I had a lumpy edge in my uterus. Doc removed it and now we are trying again....
Hi daurelia- I'm so sorry to hear about your second miscarriage. Makes it harder to know you have to wait a while to see if anything comes up. I can't remember all of your story so I'm just going to throw some other ideas out there. Did you post on the endometriosis board before? If so, I'd ask for a laproscopy with the hysteroscopy, endometriosis can cause higher miscarriage rates due to elevated prostaglandins. As far as the surgery went, I had no complications with the anesthetic but the first few hours out of surgery were the hardest. I had some nausea (gave me zofran), a little rash on my chest (gave me benedryl, which knocked me back out), and pain in my shoulders/chest from the carbon dioxide. If you just have a hysteroscopy you shouldn't have that problem because they won't fill you up with gas. After the first day I was pretty normal, not 100% for about a week, but again, with a hysteroscopy you shouldn't have too much discomfort. I don't know what it means as far as TTC. We were advised to wait 6 weeks. The only other thing I can think of (and only because I was just diagnosed so it is at the front of my mind) is anti-thyroid antibodies. I'm not sure how/why they effect things (especially since my TSH was completly normal, I'm not close to hypothyroid). But women with Anti Thyroid Anitbodies have a 25% miscarriage rate and 70% lower fertilization rate. It is easily treated with thyroid medicine so that is an easier fix. I know there are a few women here with that have had recurrent miscarriage testing that may have more info. I wish you the best of luck in the future!
C + B + 10y together, 6y married, 5y TTC endometriosis, Hashimoto's thyroiditis, 4 miscarriages
IVF x3, FET x3 & IVF wPGD FETx1 gave us our miracle twins (and 4 frosties)
Never give up on a dream just because of the time it will take to accomplish it. The time will pass anyway.
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Daurelia- You might want to also post this in the TTCAL threads: http://www.mothering.com/community/f/455/trying-to-conceive-after-loss
I am also homozygous for the MTHFR mutation and they are having me on blood thinners (Lovenox and baby aspirin) until 36 weeks the next time I get pregnant, in addition to extra folic acid and extra B6 and B12. I lost my twins in March due to IUGR from placental thrombosis. I have an anecdotal story of how the blood thinner protocol helped someone. A friend of mine had 2 miscarriages, went to see an RE to find out why she was having recurrent losses. They never found anything specific, but decided to try Lovenox and baby aspirin anyway. She stayed on them throughout the first trimester and has a beautiful little girl now.
There's definitely a relationship between MTHFR and Infertility, both for men and women. It is suspected it is through the mechanism of high homocysteine that there is trouble. I don't know if I can post the URL, but I have a few posts about it.
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ALE, marketed under the brand Alcatel-Lucent Enterprise, has been awarded "Enterprise Collaboration Vendor of the Year" at the Network World Middle East Awards. The vendor award is based on the positive business outcomes from Alcatel-Lucent Enterprise collaboration technologies implemented in various industry sectors in the region such as Ghanim Bin Saad Al Saad & Sons Group (GSSG), a leading Qatar-based diversified business conglomerate and Dibba Municipality.
Baher Ezzat, Regional Director, Middle East, ALE stated: "We are pleased to receive the award for our success with Alcatel-Lucent Enterprise solutions, which serves as a testament to our work in collaborating with enterprise customers in the region. In 2014, we continued to strengthen our technology implementation with key customer wins in the educational, retail sectors and government institutes. We will continue to work closely with our partners and customers in collaborating on new enterprise products and solutions."

subset: commoncrawl


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Gyor Gifts For Men
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You can send Gifts For Men to Hungary in the following cities.
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text: Skype currently has a fairly sweet promotion going on. They are offering 1-year of premium service for free to anyone who submits their email on their promo site. Skype premium extends the free experience by offering group video calls, group screen sharing, dropping advertisements and throwing in live chat customer support. We here at WindowsForum.com benefit greatly from these features as they help increase productivity during staff meetings. Most people could also take advantage of these features, for example you could chat face-to-face with your all of your family members worldwide in a group . Even if you couldn't benefit from these features, it's worth signing up for just to ditch advertisements. Check out the promo below, which is about a $100 value, yours free: https://collaboration.skype.com/promotion/


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Anheuser-Busch InBev has agreed to sell SABMiller's premium Peroni and Grolsch beer brands to Japan's Asahi Group, in a deal worth $2.9bn. The deal also includes British craft beer Meantime and related businesses in Italy, the Netherlands, the UK and other markets.
Asahi had made a cash offer for the brands in February, as part of its aim to expand its international presence. The deal will be the group's biggest-ever international acquisition.
The sale is one of many by AB InBev and SABMiller, as they look to gain regulatory approval for their merger. The Asahi deal, like the others, is conditional on the $108bn merger going through.


text: In Personal Conversation Moderator Permissions what does ( Always invite participants to conversations: ) means ? and about the private messages when some report a content in a private message , can moderator see the content ? at the top ( Reported Items: 0 ) who can see these reported item and manege them because i can't find any permission for which to control user group regarding these items


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Let us know when your receive great advice so we can thank our lawyers and point others with similar questions in the right direction.Got it!
What rights do the parents lose if guardianship is placed with a family member? I have not been able to get a strait answer from any one. My daughter has ADHD and a possible mood disorder. She is only six. My parents filed for guardianship even though they do not know what the consequences mean for me. They want me to just agree and not fight it, but I can't do that without knowing what will happen to my rights as her mother. They have power of attorney, but they want her on their insurance so she is free to get treatment out of the county. I just have medicaid for her, and they don't think it is good enough. What is worse is they did this behind my back, and I found out about it from my sister who lived next door. When I found out about it they did come clean, but I am having big misgivings about this whole ordeal. I have been trying to research this online and through local lawers, but I haven't had any luck. I am hoping you can help. I don't even know whether or not to fight it. I need to weigh all of the pros and cons before making my decision, but I don't know all of the cons. I am at my wits end, and in a bad struggle internally. Please help me.
The Court typically considers the best interest of the child. Your parents do not have a greater right to custody/guardianship of your child under that standard unless you are "unfit". Guardianship is a fluid concept and can change. However, once that child has been living and bonding with someone other than a parent it becomes difficult to change the status quo. The courts like children to be in a stable loving environment. You do not lose your parental rights without the filing of a formal proceeding and a showing of unfitness. However, when a nonparent has guardianship/custody of a child it is crucial for the parent to maintain a presence in the life of the child. Meaning, You must visit and spend quality time with the child to make sure the child continues to be emotionally attached to you as a parent. The court will also look at financial support if you want to change guardianship/custody back to you( the parent).
Be careful, once you give someone custody or guardianship you will have to fight to get the child returned to you unless there is an agreement between the parties.
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Ettix HMB Tablets are a protein supplement in tablet form to help support and maintain muscle growth while also assisting in muscle building.
Etixx HMB Protein 60 Pieces
£ 26.99
2 in stock, ready to dispatch.
UK, EU and Worldwide delivery available.
Available for Reserve & Collect.
Etixx HMB Tablets 60 pieces
Etixx HMB Tablets with protein help to support and maintain muscle growth while also assisting in muscle building. HMB (hydroxymethylbutyrate) is a metabolite of protein derived from the breakdown of the essential amino acid leucine. Protein contributes to muscle growth & supports muscle mass maintenance
Whether you are a cyclist, footballer or rugby player strength plays a fundamental role. Even an endurance athlete will benefit greatly from gaining strength and building their muscles. To maximise the effects of your training it is vital you work hard and choose the right nutritional supplements before, during and after. With this in mind, Etixx has created a range of products to complement and enhance your strength training with the HMB tablets being one of those products.
Instructions For Use
- 4 tablets a day
Nutritional Information
**Composition per 4 tablets:
HMB (hydroxymethylbutyrate): 3g
Whey Protein: concentrate 1g
- Assists muscle building
- Contains Leucine Metabolite
- Added whey protein
- For Muscle Mass and Maintenance
UK Delivery Options
Free Delivery on all orders over £30
Estimated delivery within 4 working days (a delivery charge of £1.99 for orders under £30.00 will apply)
CollectPlus Delivery
Have your order delivered to your local shop for just £1.99! For Highlands and Islands, please allow up to 5 working days. Orders can be shipped to UK CollectPlus locations specified on the SigmaSport.co.uk website where they will be held awaiting collection for a period of 10 days.
Orders placed are normally dispatched within 2 working days.
Priority 1st Class Delivery - £2.99
Estimated delivery within 2 working days.
Next Working Day Delivery* - £4.99
A guaranteed tracked courier delivery, place your order before 3pm, deliveries are made Monday to Friday.
Saturday pre 12 Delivery - £4.99
Saturday delivery orders must be placed by 1pm Friday and is only available on items in stock in our warehouse. Orders are prioritised through our warehouse and are delivered on Saturday pre 12pm by courier. Package must be signed for upon delivery.
Sunday pre 12 Delivery - £4.99
Sunday delivery orders must be placed by 1pm Friday and is only available on items in stock in our warehouse. Orders are prioritised through our warehouse and are delivered on Sunday pre 12pm by courier. Package must be signed for upon delivery.
Reserve and Collect** - FREE
Reserve & Collect is available on all items marked 'Collection'. It is a FREE delivery option that allows you to collect your order from either our Sigma Sport Store, Hampton Wick or our Reserve & Collect location in Esher. Just select the Reserve & Collect button in the basket.
** Reserve and Collect Collections - Clothing, parts and accessories: Next day. Orders placed on Friday, Saturday or Sunday will be available for collection after midday on the Monday (excluding Bank Holidays). Bikes: 4 days if in stock at store, collect in up to 7 days (sometimes quicker) if in stock at warehouse.
* Next Working Day delivery is only available on items in stock in our warehouse and excludes pre- order items. Next Day refers to the next working day, Bank Holidays will add an extra working day to the estimated delivery lead times. UK next day excludes Saturday deliveries. This service is not available to some remote postcode areas. Please contact us for help.
London Same Day (Order Before 1pm)
We offer a Same Day delivery service into London. The cost is £25.00 under 2Kg and £35 over 2Kg. Place your order before 1pm, deliveries are made Monday to Friday. Please note this option excludes bicycles.
More information on our Same Day delivery options.
Bike Deliveries
All our bikes are fully checked and tuned and tested by our Cytech qualified mechanics and then securely packaged, ready for despatch. All you have to do is add the pedals, rotate and tighten the handlebars. Typically we can deliver your bike in 4 - 5 working days.
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International Delivery and Returns
We ship to over 100 countries using Tracked Post or DHL for fast and reliable deliveries. To see delivery options and delivery times, please add your items to the basket and proceed to the checkout.
International customers have 30 days from their order date to return unused and unopened purchased items.
Please note we cannot accept any goods back if the original packaging is opened. For full details, see this link.
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We offer a free returns service for our UK customers. Sigma Sport will happily refund or exchange any item purchased at Sigma Sport, excluding Sigma Sport gift vouchers and personalised products except when faulty.
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text: Hi! First I would kindly ask forum admins to transfer my topic to more suitable subfolder, I really don't know here to post my problem. Thanks. Now to the problem. I have Asus N55SF laptop, with Windows 7 SP1 64 bit. Also, I have 2 external hard drives. One with USB 3.0, and one USB 2.0. Following problems, I am going to describe below, happen to the both of them. Just to mention, external drives are tested on desktop computer and following problems do not happen. Let me now describe what happens when I try certain actions: - When I try to copy large files (10 or more GB) I get an error that destination is no longer visible. External drives disappear from My Computer and I can't do safe remove. But when I copy files using programs FastCopy or TeraCopy everything copies well and drives do not disappear. - When I try to do Windows Backup and encrypt them using BitLocker drives also disappear, and are not visible within OS. - There is a difference between external hard with USB 3.0 port and the one with 2.0 port: --- when one with 3.0 disappears after described actions I can't see it from Device Manager, I can see it only after windows reboot. USB 3.0 disk connects to one USB 3.0 port on laptop. --- when one with 2.0 port disappears I can see it from Device Manager, and I only have to unplug it, and plug it in again to see it. USB 2.0 disk connects to 2 USB 2.0 ports on laptop. Common to both disks is that when then disappear from My computer the diode on the external disk cases are still flashing, what probably means that they have some power. Both disk are formated to NTFS, and Allocation unit size is set to: Default. Their removal policy is set to: Better performance (default). On laptop I only have Windows, Office and Asus drivers. Antivirus is: MSE. Thanks for replies


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16365 County Road 20, Mayer, MN 55360
About the Listing
Nearly 5 acres of picturesque privacy! 4 bedroom, 4 bath, walk-out home with hardwood floors, granite countertops, vault, lots of cabinets & storage, cedar siding, heated & insulated garage. Relaxing front porch, above ground pool with large decking, landscaped yard, pond, mature trees. Great southern views!
Share Listing
Property Details for 16365 County Road 20, Mayer, MN 55360
Bedrooms: 4
Bathrooms: 1 Full | 2 Three-Qtr | 1 Half
Lot Size: 4.89 Acres
Lot Dimensions: 4.89 acres
Year Built: 1990
Garage Dimensions: 3 car
Garage: Attached Garage, Insulated Garage, Heated Garage, Driveway - Gravel, Garage Door Opener
Style: (SF) One 1/2 Stories
Water: Well
Sewer: Private
Square Feet: 2942
Above Ground Sq Ft: 1832
Below Ground Sq Ft: 1110 (approx)
Room Information for 16365 County Road 20, Mayer, MN 55360
Main Floor
Living Room: 12x12
Dining Room: 11x11
Kitchen: 13x11
Bedroom 1: 13x12
Informal Dining Room: 15x12
Deck: 12x8
Lower Floor
Family Room: 27x12
Bedroom 4: 12x8
Amusement Room: 11x9
Upper Floor
Bedroom 2: 16x12
Bedroom 3: 12x11
Dining Room Description: Separate/Formal Dining Room, Informal Dining Room
Family Room Characteristics: Lower Level
School Information for 16365 County Road 20, Mayer, MN 55360
School District: Watertown-Mayer
School District Phone: 952-955-0480
Interior Features for 16365 County Road 20, Mayer, MN 55360
Appliances: Range, Microwave, Dishwasher, Refrigerator, Water Softener - Owned, Air-To-Air Exchanger, Furnace Humidifier
Air Cond: Central
Heating: Forced Air
Fireplaces: No
Basement: (1110 sq Finished) Walkout, Full, Finished (Livable), Drainage System, Concrete Block
Exterior Features for 16365 County Road 20, Mayer, MN 55360
Lot Description: Irregular Lot, Tree Coverage - Medium
Lot Dimensions: 4.89 acres
Roof: Asphalt Shingles, Pitched, Age Over 8 Years
Zoning: Residential-Single
Financial Considerations for 16365 County Road 20, Mayer, MN 55360
Tax Amount: $3,547
Taxes w/Assessments: $3,594
Tax/Property ID: 060100700
Tax Year: 2016
Monthly Payment = $0
INRIX Drive Time
Calculate Your Drive Time From This Property
Similar Listings For Sale
The data relating to real estate for sale on this web site comes in part from the Broker Reciprocity Program of the Regional Multiple Listing Service of Minnesota, Inc. Real estate listings held by brokerage firms other than the owner of this website are marked with the Broker Reciprocity logo or the Broker Reciprocity thumbnail logo and detailed information about them includes the name of the listing brokers.


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Callum Lerwick wrote:
On Fri, 2008-02-15 at 14:17 -0500, Alan Cox wrote:But its set by policy files so if you want other users to broadcast your webcam over the internet all day, listen to all your calls and send them to friends you can configure it that way, but that should not be the default.Lets not throw around straw men. Some of us just don't want to stop the rock. www.youtube.com/watch?v=LfXKkNo7YZ8 www.youtube.com/watch?v=oOTwOiDrysI Proposal: Two checkboxes in the Sound control panel: [ ] Mute my audio when switching to another session [ ] Mute other sessions audio when switching to my session First option allows your music to keep playing when switched to another session. Second option provides a defense if the first option is abused.
That sounds simple and neat enough, but the reality is there still must be policy behind it to 1) prevent these settings from being effective in a multiuser environment where a security policy is needed, and 2) to make these work without conflicting (obviously your suggested two options must have a hierarchy, the second overriding the first in other's accounts). The question remains who is most 'entitled' to have their settings respected?
I actually like to work in virtual terminals while playing music in my X session which is clearly problematic with default settings, but I understand the arguments being made for better control and securing device access in other situations.
-- Andrew Farris <lordmorgul gmail com> www.lordmorgul.net gpg 0xC99B1DF3 fingerprint CDEC 6FAD BA27 40DF 707E A2E0 F0F6 E622 C99B 1DF3 No one now has, and no one will ever again get, the big picture. - Daniel Geer ---- ----


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Brand District was founded in 2015. After working for many years in product development, production and sourcing for different fashion brands, it felt the right time to make a change. In July 2015 Brand District was founded, a sales agency for fashion and accessories brands. Using my gained product experience while selling the collections is a great asset. Retailers appreciate this extra knowledge I can add to the product.
Brand District
Showroom Address:
Johan van Hasseltweg 28B
1022 WV Amsterdam
Invoice Address:
Buiksloterbreek 22
1034 XC Amsterdam
Tel + 31 (0) 611 300 423


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|Property type
|Minimum Stay
|2 nights
We are located in the heart of the Flambeau River State Forest. The Flambeau River State Forest offers a variety of recreational opportunities during all seasons for the outdoor enthusiast. This rustic cabin has a functional floor plan with its fully equipped kitchen and split log kitchen table. The living room is anchored by a full-wall, stone, wood burning fireplace and is flush with light filtered through the antique windows.
The three bedrooms are all roughly the same size and are furnished with twin beds & dressers with one having a bunk bed set in it. Bedroom #1 can be converted from a twin to king bed. The cabin can host up to nine people by utilizing the full size sofa sleeper. Each room's central LP heat vent can be individually controlled. There are no enclosed closets in the bedrooms but rather a suspended, hard closet rod upon which to hang street clothes or heavy, wet hunting/fishing gear so that it dries. The bathroom has a tub/shower combination. The enclosed entryway covers wood for the fireplace and has shelf space for coolers and other equipment. Enjoy your morning coffee on the back deck as you view Long Creek.
Long Creek runs along the backside of the cabin and gives you access to the North Fork Flambeau River. We are also located on Snowmobile/ATV trail #25 next to business #1. So no need to trailer just get up and go.
There is an outdoor dog kennel available to use.
Cabin Includes:
-Local phone - no long distance
-Fully equipped kitchen
-Basic cleaning supplies: dish soap, trash bags, dish sponge etc.
-Outdoor grill
-Wood burning fireplace (wood provided fall & winter)
-Outdoor fire pit (must provide own firewood)
-Lawn chairs (4)
-Patio table & 4 chairs
Don't forget to bring:
-Towels (shower/swimming)
-Charcoal & lighter fluid
-Personal items: shampoo, deodorant etc.
We love living in the Northwoods and all it has to offer. We are very avid outdoors people who truly enjoy hunting, fishing, kayaking, campfires, and living on the river. We live everyday where most people come to vacation. We have three children that keep us on our toes.
Josh & Kaisa Schuelke purchased this cabin in 2014
We both grew up in the Northern Wisconsin area. We bought the cabin in 2014 when the former owner offered it to us. We like the location in the heart of the Flambeau River State Forest and close to our home. This cabin has such a unique rustic quality and a great story of how it came to be where it is.
~HUNTING~ The area has some of the best grouse, woodcock and whitetail habitat in the country. Regardless of what you are after, with 90,000+ acres at your disposal, yours days afield will be filled with adventure.
~FLAMBEAU RIVER & BASS LAKE~ The Flambeau River consists of the N. & S. forks which contain Class I-IV rapids for advanced canoers and kayakers and also have placid stretches for those looking for an easy float. There are campsites located on both forks and shuttle service is available at Big Bear Recreational Rentals located next door. Bass Lake, located deep in the forest off Tower Rd. (get directions from the Forest Office) is a non-motorized wilderness lake awaiting your fishing or floating enjoyment. There is parking and a groomed trail to the lake to carry in your gear. Pack a picnic lunch and eat near the launch at the base of a large hemlock grove.
~CHIPPEWA FLOWAGE, CONNORS LAKE AND LAKE OF THE PINES~ The nearest launch for the 'Big Chip' as it is know, is just north of Hwy 70 on Cty Rd. CC north of New Post, WI. This flowage, known for record muskies, is largely undeveloped and loaded with numerous islands so bring a map. Pack lunch and pull up on any of the 140 islands for your own private break in the fishing action. Connors Lake is known for walleye and has great sand beach & playground which is within walking distance of the boat launch which is great for children. More developed than Lake of the Pines, it's crystal clear. Lake of the Pines, known for good pan fishing, also has a beach (at the campground) and a launch.
~Hunting/Fishing~ licenses can be purchased at The Flambeau River Office, across the street from the cabin. Bait can be purchased in Winter or Phillips.
~ATV's/SNOWMOBILING/ SKIING~ The cabin is located on trail #25 next to business #1. The forest contains mile and miles of trails for all types of activities with maps for each available at the Forest Office, across the street from the cabin.
The cabin was great. There was plenty of room and well taken care of. There are many fishing opportunities all within walking distance of the cabin and Reds is right next to the cabin if you don't feel like cooking or mixing drinks yourself. I would recommend this cabin for anyone.
10 people there for 2 day ice fishing, plenty of room!
The cabin is all that we had hoped and more. The dreary weather was all the more reason why the large fireplace was so welcoming. I would definitely stay again as the cabin has all the amenities that one would need for two days or the entire week.
Our group of 8 stayed 5 nights over New Year's. It worked well for our group. Plenty of room to park our trailers and sleds. Snowmobile trail is just out the door, gas available next door at Red's Big Bear. Trails were OK as it was early season. Since our stay they'very got lots more snow. Cabin was clean and comfortable. Loved making a fire in the stone fireplace each night to warm up. Kitchen was well stocked with large crock pot, griddle, coffee pot, etc. Owners were accessible. We will be staying here again for winter sled trips as it fit our needs. Thanks for the hospitality!
The cabin was very clean, and extremely cool. Very cozy with all the comforts. One of our sons thought we should move there.
Josh took care of anything that was needed, which was pretty much taking care of us on a kayak trip down the river, because everything else was well prepared. They leave you alone unless you need something from them. We were there for 4 days and mainly spent our time riding our ATVs around the area trails. The trails were good...a little too good (like roads), but we found better/more challenging riding up in Chequamegon Forest, and it's a short ride on nice trails to get there. We also did some fishing and kayaking. We mostly brought all our own food, so we didn't try the restaurant for anything other than some drinks ;) What we saw looked good, and people gave favorable comments. We had a great time, the weather was perfect, and we'll definitely be back....maybe even for snowmobiling.
Our only complaints, and these aren't really complaints but suggestions, were in the yard around the cabin. It's well maintained and has a nice lawn, but with it's proximity to the bar/restaurant and canoe rentals, it could be made a little more private. Even a privacy fence on two sides would be a big improvement with some "No Parking" signs. We had a couple people park pretty much in the yard to go to the restaurant. Even so, it was still nice and quiet. We don't have any complaints of being near the restaurant as far as noise or anything. The grill.....hmmmm....it's a standard Weber Kettle, but the grates were so corroded away that you had to put something on it to keep the food from falling through. We bought a lower (for the charcoal) grate and left it for them, but couldn't find the cooking grate locally. Minor thing I'm sure Josh will fix....he just may not have known. We had brought some wood for the fire pit, but it was located in an undesirable location, so we never used it. It might be a product of the trees surrounding the cabin for safety, but it was down by some tall weeds and not really "friendly". Maybe a new spot would be better.
All in all, we loved it, and our two teenage boys had a great time....we even got them off their phones for a few days. I'd definitely recommend it.
We had a great time enjoying the north woods! The cabin was perfect with a nice location to UTV/ATV trails and having the restaurant in walking distance was very convenient. Thank you for the outstanding accommodation!
We are located in the heart of the Flambeau River State Forest. The Flambeau River State Forest is a 90,147 acre unit of the Wisconsin state park system. The North and South Forks of the Flambeau River join within the park, providing over 75 miles of mostly undeveloped river. Fishing, hiking, mountain biking, birding, and 38 miles of signed ATV trails. 22 miles of cross country skiing- 14 miles groomed; 8 miles ungroomed.
Big Bear Recreational Rentals is located next door to the cabin.
Renting: Pontoons, Fishing Boats, Canoes, Kayaks, and providing shuttle services.
|Rate Period
|Weekend Night
My Standard Rate
2 night minimum stay
|Notes: Rates are based on 4 guests; add $10 per night, per additional guest
|Pet Fee
Weekly Rates are based on 4 guests, 5 to 9 guests the rate will be $650.00.
Nightly Rates are based on 1-4 guest, additional guest $10.00/night per guest.
Rates are subject to change until reservation is confirmed.


text:
Belgium had to be content with a draw after their neighbours took a shock lead before the visitors equalized late in the game
Chelsea edged past a fighting Liverpool side with a narrow 1-0 victory at the Rose Bowl, Pasadena, on Wednesday.
Sevilla ultimately triumphed in a game of two halves against Liverpool on Wednesday, with the Spanish side winning a record third consecutive UEFA Europa League title.
Liverpool FC and Arsenal FC played out an entertaining 0-0 draw at the Emirates last night. We look at Liverpool FC's individual performances from the game and rate them.
Liverpool bounced back from a disappointing draw against West Brom to thrash Arsenal 5-1 at Anfield in a thoroughly entertaining game. Two goals apiece from Skrtel and Sterling and one from Strurridge ensured that Arsenal started their run on tough games with a morale crushing loss. Player Ratings LIVERPOOL SIMON MIGNOLET: He was largely untested in the first half, and made a few smart saves in the second. He could do little to keep out the penalty, but it was an otherwise sound display from the Belgian. 6/10 JON FLANAGAN: The right back look more and more at home with every passing game, and he got forward to great effect. Showed loving passing ability with a couple of first time balls, and gave the Arsenal players little joy down his flank. 8/10 MARTIN SKRTEL: The big Slovakian was outstanding today, and was a real threat from set pieces, get on the end of two exquisite balls from Steven Gerrard. He […]
Chelsea manager Jose Mourinho produced a tactical master class to outsmart Manuel Pellegrini's Manchester City side to secure the valuable 1-0 victory.
TheHardTackle rates the Real Madrid players on the basis of their outings in a largely disappointing 2012-13 season for Los Blancos
TheHardTackle reviews the performance of Manchester United players in the season in which they won yet another Premier League title.
In a season wherein Chelsea played in 7 competitions winning just one, it is fair to say that majority of the players didn't perform at an optimal level. TheHardTackle looks at how they fared through the season.
The international break appeared just when Chelsea were beginning to show their true potential this season. With 10 games into the season, TheHardTackle analyses the performance of the club, with a look at the tactics, formations, and players.


text:
|232 m²
|Tipo de imóvel
|Estadia Mínima
|5 - 7 noites
Lindo Beachfront Início Story 2 com vistas espetaculares do oceano 6 BR, 4 BA
Vistas espectaculares sobre Honolulu / Waikiki / Diamond Head são vistos a partir desta casa à beira-mar, na costa sul de Oahu. À noite, você pode exibir tanto as luzes da cidade e as estrelas no céu com brilho igual a partir do seu terraço privado. Amanheceres e entardeceres espetaculares são vistas do nosso deck, perto da borda da água. Localizado na aldeia de Ewa Beach. A casa BA no térreo 3 BR, 2 é chamado o Ewa Lua. O quarto principal com banheiro em anexo tem uma cama queen; a Sala Azul tem uma cama queen, eo quarto Hawaiian tem 2 camas individuais. Esta casa com decoração havaiana do vintage e área circundante tem a sensação de Old Hawaii e parecem ter parado no tempo. Coqueiros altos balançam na brisa, como você passear ao longo da praia. Pescador local arrematar o litoral e peixes lança no recife. O andar de cima Hula Lua 3 BR, 2 BA tem uma grande varanda aberta com ampla vista para o oceano. Um toldo retrátil motorizada feita sob encomenda alemão enfeita a grande varanda no andar de cima. Cada unidade alugados separadamente ou em conjunto para grupos grandes. Cada nível é de 1250 SF. Total de 2500 SF. Cada unidade acomoda máximo de 6 pessoas, incluindo crianças e bebês. Casa completa acomoda máximo de 12 pessoas. Separe casa Blue Moon na mesma propriedade, não em frente à praia, também está disponível para aluguer de férias. Fica a 3 quartos, 1 banheiro e acomoda até 6 pessoas (incluindo adultos, crianças e bebés). Com esta casa adicional, a capacidade desta propriedade é de até 18 pessoas no total (incluindo adultos, crianças e bebés). Veja VRBO # 446725 para ver a casa Blue Moon.
Com entrada privativa para o segundo andar, o "Hula Moon 'tem excelentes vistas. Os hóspedes do segundo andar Hula Lua são permitidos acesso à praia. As áreas de gramado, deck praia e piquenique são reservados para os hóspedes do primeiro andar Ewa Lua. Livre de alta velocidade Wi-Fi à Internet. Gratuito e ilimitado de telefone de longa distância para as Ilhas EUA / Canadá / Vizinho. Estacionamento ar-livre gratuito para um carro no local.
Apenas a 5 minutos de distância é Starbucks Coffee; 2 minutos é um novo Safeway; Foodland supermercado é de 3 minutos. Mais perto compras de supermercado no Longs Drugs for inferior a um minuto de distância. Em nossa cidade, temos vários pequenos restaurantes com variedade étnica, bem como os habituais fast food lugares. 15 minutos é o popular Waikele Outlet Shopping Center, freqüentado por turistas de todo o mundo.
O melhor começo que surfa em Oahu é encontrado aqui. Você pode pescar a partir do seu quintal da frente (equipamento não fornecido), o sol em sua plataforma praia, ou fazer um piquenique debaixo de sua árvore de sombra. Você é de três a cinco minutos de seis campos de golfe, incluindo o Hawaii Prince Golf Course! Estado da arte Parque Aquático com flo rider é de 7 milhas de distância. O Kapolei 12 Plex Theatre é de 6 milhas de distância. Esta fuga é ideal se você quer evitar mega resorts e áreas turísticas montado.
Hawaii Imposto ID # W05044512-01
Palavras-chave: House 'O Ewa Moon'
The moment I walked in to the living room, I KNEW we made the perfect choice. The view is PHENOMENAL! We opened the patio doors and the view got even better. We rented both Ewa Moon and Hula Moon for our week long trip. My only regret is that we couldn't stay there forever. The house is beautifully decorated, clean and inviting. To be quite honest, coming from the Midwest, I was a little concerned about not having AC but I would not have wanted to miss the sounds of the waves.
Dr. Dolly and David left us a note on arrival that they needed to do a small maintenance project and would be by during the day. They stayed to visit with us and gave us suggestions on things to do while we were there. It felt like we had known each other for some time.
Even with all the amazing things to do (Waikiki Beach, Diamondhead, Pearl Harbor, The North Shore) I could have been just as content to sit at the sea wall and watch the waves. I highly recommend you consider renting this place for your stay. It has all the comforts of home with an extraordinary view. We have already begun saving for another trip to Hawaii so we can stay there again!
Thanks again Dolly and Dave! Please let us know if you ever want to come to Indiana!
This rental was a wonderful place to stay!! it was very clean & everything worked great! The inside was decorated with antiques & history of Hawaii. It made you feel the beauty & calmness of Hawaii. The home was about 50 feet from the beach. The front yard has a table & chairs next to the beach wall where we spent most of our time watching the ocean. On the front porch there was a swing & rocking chairs. It was a short drive to a Safeway grocery and many other stores etc.We met the owners & they were great people. They were very concerned about our happiness while staying there. We hope to go back to Hawaii again & plan on staying with them again!!!
Our family of 9 including our seven year old grandson enjoyed the Ewa Moon and the Hula Moon rental units for ten nights. The rooms were spacious, comfortable and clean for both Ewa and Hula Moon. The rooms and furniture had an authentic Hawaiian motif and each units living space accommodated all nine of us. There is also a piano in the downstairs unit. We enjoyed the beach only steps away and also the Ewa public beach a very short drive away. The views of Honolulu and Diamond head during sunrise were beautiful. We walked on the beach most mornings and our grandson loved the waves and helped find beach glass and shells. We did our swimming on other beaches during our travels around Oahu and Hawaii. The upstairs lanai had great views and the porch swing was great for lounging. The property was perfect for our group of 9 everyone had a great time. We traveled all over the island of Oahu, visiting the North Shore for shaved ice at Matsumoto Shaved Ice, the Polynesian Cultural Center for a great show called Ha- Breath of Life and a great Luau, we climbed Diamond Head and hiked into Manoa Falls. We also flew to the big island, Hawaii for a day trip and visited the Volcano National Park. The property is just a short drive from the airport and Pearl Harbor, a great place to visit. The Ewa and Hula moon rental was a great place to return to after each days adventure. We would recommend staying here to friends and family that would enjoy quiet residential living. We hope to visit again someday.
We rented both Ewa and Hula Moon locations for our parents wedding anniversary, 10 adults. Both units were clean and decorated with a true Hawaiian theme. The beach was secluded, private, but rocky. I would not recommend it for small children as the currant and tide are quite strong. Dave the owner was fantastic when we told him one of the ceiling fans was broken – he came out within a few hours and replaced it! We knew the units didn't have AC when we rented them, however it did not cool down much during mid- July and was quite warm in the evening to try to sleep.
We recommend Germaine's if you want to see a great Luau – only 25 minutes from Ewa Beach. Also make the drive to Kualoa Ranch on the north side of island, we took the Mountains – Jungle Expedition tour as well as the Ocean Voyage tour….both were excellent. Great place to eat there also and a souvenir shop that was awesome.
The view was worth a million dollars. I rented both Hula and Ewa Moon for my family of 12. At times it was very hot in the house. Most of the time we used the downstairs Ewa Moon and they only slept upstairs because it was quite hot. We found both units clean and comfortable. We did see a few cockroaches in the house probably due to the heat, as the house was clean. We didn't use the beach as the tide was in most of the time when we would get back to the house but just having the view was enough to keep us on the porch at all times. Although the house is a ways from attractions I'd recommend staying there due to the quiet and getting away from the hustle and bustle and commercialism of Honolulu. We ate all but 1 meal at the house everything we needed to cook was at our disposal, Great place to stay!!!!
I rented both the Hula Moon and Ewa Moon units for a ladies trip, 8 of us total. It was spacious and nicely located for all of us.
The house is exactly as described only the pictures are a little outdated (house is a different color on the outside now) and don't do it justice, the house was better than expected and so were the views. Very clean. The only con I found was most of the house cools down at night for sleeping but there was one bedroom that didn't (upper level) and it was really warm during the day, but that was to be expected. The upper level in general was hot (but we expected it to be). We mainly congregated in the lower level and on the porches, we used the lower levels kitchen because it was bigger and had seating for all of us. On our first night in the upper level there was a cockroach in one of the bedrooms (the bedroom that was super hot) but warm weather is their natural habitat so could happen anywhere, it wasn't because the place was dirty. We only saw the one.
The beach area is more oceanfront than beachfront depending on the tide, the beach hours seemed to be in the morning, but well there's beaches all over so it's not hard to find another if the tide is too high.
It's in a nice quiet residential neighborhood and away from touristy areas. The neighbors who live local were friendly and helpful as were the neighbors also there for vacation. We made friends with a couple of the local neighbors and one even invited us to a party they were having at their house so we went. The con of being in a residential area most attractions are 40-60 minute drive with traffic (but great views along the way).
Aside from some picture updates the only other thing is the lock boxes the keys are in could be updated they're hard to open and close but we were able to do both with them.
Parking is a bit tight but still adequate (we had 2 cars), the houses on the street are close together and there's a lot of people parking on the road so it's sometimes hard to see backing out.
Dolly & David were good about answering any questions we had prior to our arrival but we didn't have any issues while we were there so we didn't contact them while we were there.
Wifi worked great.
I would definitely stay there again and recommend to others.
Tartaruga e monge selo assistindo do seu Deck nesta casa de praia. Water Park e cinema teatros em Kapolei, 6 campos de golfe dentro de 4 milhas, tomada de compras nas proximidades, em Waikele e Kapolei, Natação e Mergulho, 5 man feitas lagoas para nadar fácil no Ihi 'Lani Resort e Disney Resort, Au'lani 12 minutos de distância, Pearl Harbor Arizona memorial a 25 minutos, praia White Plains com o melhor embarque longo novato em Oahu e estacionamento gratuito, a 10 minutos de distância. Luaus na Germaine de e Paradise Cove 10 minutos. Centro Cultural da Polinésia e luau 40 minutos. Waikiki Beach 40 minutos de distância.
|Validade da Tarifa
|por noite
|Noite (fim de semana)
|por semana
|por mês
|Pacote ou Evento
mar 3 2017 - dez 17 2017
Estadia mínima: 5 noite(s)
christmas/new year
dez 18 2017 - jan 8 2018
Estadia mínima: 7 noite(s)
|exit cleaning each level
|R$ 637,96 + Imposto
Possible to take one level only if 6 or less people, including children and infants, except during summer months and Christmas dates listed below. 2017: Downstairs Ewa Moon: $369/night for min of 5 nights or $1990/wk. Upstairs Hula Moon: $357/night or $1920/wk.
Xmas 2017: downstairs $2830/wk, upstairs $2715/wk. Required Christmas Dec 18-Jan 8 that same group take both levels.
2018: Downstairs Ewa Moon: $388/night, min of 5 nights or $2090 a week. Upstairs Hula Moon: $375/night, min of 5 nights or $2015 a week. No booking over one year ahead.
To rent the Blue Moon, house on the same property, see www.vrbo.com/446725 for rates on that website. Entire property with Blue Moon can sleep 18 people including children and infants.
50% at time of booking reservation. Remaining 50% plus refundable $350 damage deposit for each level due 30 days prior to arrival.
Payment by check or bank transfer to Dolly Langen in USD. Credit card only via paypal, and guest pays paypal fee which is approximately 3% in the US and 4% outside the US.


text:
Hydrophilic and lipophilic radiopharmaceuticals as tracers in pharmaceutical development:
Scintigraphic studies have been performed to assess the release, both
In-vitro disintegration and dissolution studies have been performed at pH 1, 4 and 7. In-vivo studies have been performed by scintigraphic imaging in healthy volunteers. Two hydrophilic tracers, (99mTc-DTPA) and (99mTc-MDP), and two lipophilic tracers, (99mTc-ECD) and (99mTc-MIBI), were used as drug models.
Dissolution and disintegration profiles, differed depending on the drug model chosen.
Scintigraphic studies have made a significant contribution to the development of drug delivery systems. It is essential, however, to choose the appropriate radiotracers as models of drug behaviour. This study has demonstrated significant differences in release patterns, depending on the model chosen. It is likely that each formulation would require the development of a specific model, rather than being able to use a generic drug model on the basis of its physicochemical characteristics.
Development of new drug formulations requires the performance of extensive studies, both in the laboratory, and
Many studies to validate the methodology mentioned above have already been undertaken
Provided that the tablet formulation can be radiolabelled with a suitable gamma emitter without altering its characteristics, imaging with a gamma camera can be used to monitor
The characterised radiopharmaceuticals were 99mTc-diethylenetriamine-pentaacetic acid (99mTc-DTPA), 99mTc-ethyl cysteinate dimer (99mTc-ECD), 99mTc-methylene diphosphonate (99mTc-MDP) and 99mTc-sestamibi (99mTc-MIBI)
Radiopharmaceuticals labelling and control
The radiopharmaceuticals 99mTc-DTPA, 99mTc-ECD, 99mTc-MDP and 99mTc-MIBI were obtained by labelling commercial kits with 99mTcO4- from a 99Mo /99mTc generator (Technonuclear). Radiochemical purity testing of the 99mTc-DTPA complex was performed by chromatographic analysis on Whatman N° 1 paper with propanone and sodium chloride solution (0.9%) as developing solvents.
99mTc-ECD radiochemical purity was studied by chromatography on Whatman N°1 paper with a methanol/water (85/15) solvent and by HPLC (Shimadzu LC-10 AS) using a Partisphere C18 (Whatman) column as the stationary phase. The mobile phases were phosphate buffer 0.0125 M pH 2.5 (A), and ethanol 100% (B). Solvent program was, at time = 0 min, 100 % A, and at time = 10 min, 70% A, 30% B. The flow rate was set at 2 mL min-1.
The radiochemical purity of 99mTc-MDP was determined by chromatography on Whatman N°1 paper using propanone and sodium chloride 0.9 % as developing solvents.
The 99mTc-MIBI complex was assessed by HPLC (Shimadzu LC-10 AS) using a Partisphere C18 (Whatman) column 12.5 cm as stationary phase. The mobile phases were methanol (A), and ammonium sulphate 0.05 M (B). Solvents program was at time = 0 min, 20 % A, and at time = 5 min, 95% A. The flow rate was set at 2 mL min-1.
Tablet preparation
Tablets were prepared by wet granulation using lactose and starch as diluents, PVP K30 (ISP Corp) as granulating agent, Ac-Di-Sol (FMC Biopolymer) as disintigrant and magnesium stearate as lubricant. The exipients were passed through a No. 16 sieve (16 meshes per centimetre) and mixed by a geometric method. After compression, tablets were assessed for weight (target weight 400 mg) and radioactivity content (target activity 18.5 MBq). Activity was measured in an ionisation chamber dose calibrator (Capintec CRC 25).
Tracer stability was verified as in a previous communication
Dissolution tests were carried out in a Vankel USP Type II apparatus, 900 mL of dissolution medium was used at three different pH values comprising pH 1 (0.1 M hydrochloric acid), pH4 (0.016 M acetic acid/sodium acetate) and pH 7 (water). Temperature was maintained at 37°C, and a rotation speed of 50 r.p.m. used. Samples of 2 mL were withdrawn through cellulose acetate membrane filters (0.22 μm) at 1, 2, 3, 5, 10, 15 and 30 minutes and assessed for radioactivity in a solid scintillation counter (Ortec-Maestro MCB1). Corrections were applied for volume, decay and counting efficiency. Curves of log % non-dissolved vs. time were plotted.
Disintegration profiles were recorded concurrently with the dissolution procedure by placing the vessels in front of a circular field of view gamma camera (Dyna (Pyker 4/15) equipped with a low energy, high resolution collimator, operating with a 20% window centred on 140 Kev. Serial images were recorded at 1 frame/min with a matrix of 128 × 128 without acquisition zoom. Three regions of interest were delineated, one on the tablet, one on the dissolution medium and the third on the external field to determine the background
Studies were performed in four healthy volunteers (2 men and 2 women) mean weight 60 Kg, mean age 38 years. They were non smokers and were not receiving any medication. Written informed consent was obtained from all subjects. They were not allowed to consume alcohol during the study period or in the preceding 24 hours. The protocol was in accordance with the Declaration of Helsinki guidelines for ethics in research and with resolutions XXIX and XXXV of the World Medical Assembly.
Volunteers fasted for 6 hours prior to the study. Tablets were administered with 200 mL of still mineral water. Volunteers stood erect during the acquisition process in front of the detector. Urine samples were collected at 30 and 120 minutes post ingestion
Serial images were recorded during the 30 minute period after administration at 2 frames / min using a rectangular field view gamma camera (Sophy). Later static images were recorded 2 hours after tablet intake.
Three regions of interest were delineated, one on the stomach, one on the intestines and a third on a region outside the body perimeter to determine the background. Net activity was quantified by subtracting mean background pixel counts from each pixel in the selected region of interest. Gamma ray attenuation was quantified by calculating the geometric means of count rates in paired anterior and posterior planar views.
Scintigraphic studies enabled the determination of tablet transit characteristics within the gastrointestinal tract specifically in the stomach. Curves of Log % non-disintegrated vs. time were plotted
Data processing
Disintegration velocity constant of the tablets was kd, which corresponded to the slope of the linear regression in first order kinetics
log [1- Qt/Q∞] = kdt / 2.303
Qt the amount of activity of the tracer disintegrated at time
Q∞ the maximum amount of activity measured in the region of interest.
Disintegration velocity constants in the stomach and the constant of appearance in small intestine were determined in a similar way, considering Qt the amount of activity of the tracer disintegrated at time
Results and Discussion
Radiotracers were incorporated during the wet granulation process of tablet preparation and appropriate controls of quality were applied as previously described
Disintegration velocity constants in the gastrointestinal tract were determined by
Dissolution velocity constants for tablets containing this lipophilic tracer showed no significant variation across the whole pH range studied and the values were very similar to disintegration velocity constants determined under the same conditions (Table
Table 1
In vitro dissolution and disintegration constants (p 0.05)
Dissolution velocity Constant (min-1) (n = 6)
Disintegration velocity Constant (min-1) (n = 6)
(0.05 ± 0.02) all pH range
(0.04 ± 0.01) all pH range
(0.040 ± 0.005) all pH range
(0.05 ± 0.01) (pH 1)
(0.09 ± 0.01) (pH4 and 7)
(0.020 ± 0.005) all pH range
(0.20 ± 0.04) (pH 1 and 7)
(0.040 ± 0.005) (pH 4)
(0.06 ± 0.01) (pH1and 7)
(0.11 ± 0.02) (pH 4)
0.011 ± 0.002 (pH1and 7)
0.080 ± 0.006 (pH 4)
The Pearson statistical test was used to quantify correlation within both series of data. Pearson's correlation coefficient
Dissolution and disintegration velocity constants (
Table 3
99m Tc MIBI
99m Tc ECD
99m Tc MDP
99m Tc DTPA
They were not so high indicating a probable retention of the radiotracer in the formulation.
This lipophilic radiopharmaceutical demonstrated identical dissolution velocity constants across the whole pH range studied, while disintegration velocity constants increased with pH (Table
Pearson correlation coefficients are shown in Table
99mTc- MIBI
No significant variability within volunteers was observed in stomach disintegration velocity constants. Small intestine appearance constant showed similar behaviour but different values and did not represent significant differences within volunteers (Table
Table 2
In vivo gastric transit constants (p 0.05)
Radio pharmaceutical
Stomach disintegration velocity Constant (min-1) (n = 4)
Small intestine appearance Constant (min-1) (n = 4)
(0.016 ± 0.006)
(0.13 ± 0.02)
From (0.7 ± 0.1) to (0.010 ± 0.002)
(0.02 ± 0.01)
(0.007 ± 0.002)
(0.037 ± 0.006)
From (0.13 ± 0.03) to (0.07 ± 0.01)
From (0.004 ± 0.001) to (0.08 ± 0.01)
Figure 1
99mTc-MIBI placebo tablet scintigraphic image 2 hours after drug intake for one volunteer
99mTc-MIBI placebo tablet scintigraphic image 2 hours after drug intake for one volunteer.
Table 4
99m Tc MIBI
99m Tc ECD
99m Tc MDP
99m Tc DTPA
Table 5
99m Tc MIBI
99m Tc ECD
99m Tc MDP
99m Tc DTPA
99m Tc ECD
In this particular case there was a substantial inter subject variability with coefficient variations during the 30-minute study period ranging from 14 to 95 % (Table
Figure 2
Scintigraphic image 2 hours after drug intake for one volunteer 99mTc-ECD placebo tablets
Scintigraphic image 2 hours after drug intake for one volunteer 99mTc-ECD placebo tablets.
Correlation coefficient was not significant when
When Pearson correlation was quantified between
99m Tc- MDP
No significant variations within volunteers were observed in stomach disintegration velocity constants. Small intestine appearance constant showed similar behaviour but different values and did not represent significant differences within volunteers (Table
Figure 3
Scintigraphic image 2 hours after drug intake for one 99mTc-MDP placebo tablets in one volunteer
Scintigraphic image 2 hours after drug intake for one 99mTc-MDP placebo tablets in one volunteer.
99m Tc- DTPA
Significant variations within volunteers were observed in stomach disintegration velocity constants and small intestine appearance constants (Table
Figure 4
Scintigraphic image 2 hours after drug intake for one volunteer 99mTc-DTPA placebo tablets
Scintigraphic image 2 hours after drug intake for one volunteer 99mTc-DTPA placebo tablets.
In this case correlation was negligible for pH 4 and higher for pH 1. When Pearson Test was used for
A good correlation was found between
As scintigraphic studies give information of a physical process, tablets containing the same components, but different tracers, might be expected to have a similar behavior in all cases. As tracers are present in low concentrations (lower than 10-9 M), it is unlikely that they are responsible for the observed differences in the disintegration constants. It is possible that the tracers are bound to different components within the tablet, which disperse at different rates, which would be a likely explanation. Although the dissolution profiles might be expected to differ depending on the model drug used, the same would not be expected of the disintegration profile. This suggests that the measured disintegration profile can depend on the model chosen.
The radiopharmaceutical 99mTc ECD showed absorption in the gastrointestinal tract. This is not a desirable characteristic and makes it an unsuitable tracer for this type of study. It was probably the main factor giving rise to the greater inter individual variability disintegration velocity constants observed when
Despite the physicochemical differences between 99mTc-MIBI and 99mTc-DTPA, both tracers presented very low correlation coefficients when
Only 99m Tc-MDP showed high correlation coefficients both
Even though 99mTc-ECD, 99mTc-MIBI and 99mTc-DTPA showed high
The hydrophilic radiotracer 99mTc-MDP was the only radiopharmaceutical suitable as a drug model for this particular tablet formulation in the prediction of its
The method is an interesting tool especially at early stages of pharmaceutical formulation development when different formulations are being chosen, but may not have adequate sensitivity to discriminate between formulation variables.
Careful choice of drug model, together with substantial
Competing interests
The author(s) declare that they have no competing interests.
Authors' contributions
Mrs. Mariella Terán carried out all the experimental work and together with Dr. Eduardo Savio made substantial contributions to conception, design, analysis and data interpretation. They also gave their final approval of the version to be published. Mrs. Andrea Paolino contributed to data acquisition, analysis and interpretation. Dr. Malcolm Frier was involved in revising it critically for important intellectual content.
The authors thank TECHI S.A. for supplying radiopharmaceutical kits and Centro de Medicina Nuclear, Hospital de Clínicas for Nuclear Medicine equipment facilities.
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Coordination compounds in Nuclear Medicine
Centellografía en el desarrollo farmacéutico: Estudios
Usage of radiopharmaceuticals in the development of pharmaceutical drug delivery systems: validation of 99mTc-DTPA and 99mTc-ECD
Nuclear Imaging in Drug Discovery, Development and Approval
Advances in Pharmaceutical Sciences
Using product visualization techniques to characterize dosage form performance in man
Imaging of oily formulations in the gastrointestinal tract
Three dimensional visualisation of the large bowel: A potential tool for assessing targeted drug delivery and colonic pathology
Oesophageal transit, disintegration and gastric empting of a film – coated resindronate placebo tablet in gastro – oesophageal reflux disease and normal control subjects
Esophageal transit of risedronate cellulose – coated tablet and gelatin capsule formulations
Control de calidad biofarmacéutico de medicamentos
Pre-publication history
The pre-publication history for this paper can be accessed here:


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For all who may be finishing up their 2011-2012 season, already finished, soon to be finished, or finished for just a little bit; dancehealthier hopes that your layoff will be a good one. For those who have or are celebrating their retirement, and those that may be moving on to new stages, congrats! And to all that are looking for a recharge, there is no better time than the now.
- Take trips, go camping, volunteer, garden, donate your time to be a big brother/big sister, visit other art forms, go fishing, take bike rides, pack a picnic, enjoy the sunshine (really), read books, educate yourself, write a short story, find new recipes, visit local farm markets, hike, watch the sun rise, exercise, take a road trip, start a journal, find new areas of town, take cooking classes, guest dance
- Teach someone else dance, take pictures, go to the zoo, visit a farm, get an ice-cream, go to museums, pick flowers, salvage something, spend time with your family, have conversations, hand write a letter to someone, go star gazing, swim (fresh water, salt water, chlorinated water – all of the above), take walks, catch up on films, contemplate, take yoga, visit friends (they give you perspective)
- Get on a boat (canoe/kayak works too), go to a baseball game, play games, sit around a bonfire, reminisce, embrace nature, read the New York Times (challenge yourself to a crossword), take a train ride, ask your parents/grandparents about their lives, sketch something, throw a frisbee, take advantage of our national parks, find shapes in the clouds, celebrate accomplishments, set new goals, explore architecture, walk through a college campus and feel the energy
- Play catch in a park, take long showers, throw a football, grill out, create things, build something with your hands, take naps, change your room around, play trivia, go somewhere you have always wanted to go, sew, help someone out, help people out, give advice, sit and listen, go to a music festival, learn to play an instrument, go for something, ask advice, dress up, get out and about, put the computer down but then pick it back up to check out dancehealthier :)
dancehealthier looks forward to the summer months to share more stories, more research, more news, more interviews, and more integration. So visit often, share and feel free to comment requests.


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The hotel comprises a total of 150 well-soundproofed rooms. Facilities on offer in this air-conditioned establishment include a foyer with a 24-hour reception, a safe, a lift, and a currency exchange counter. Culinary options include a bar, a caf�, and an air-conditioned � la carte restaurant, with highchairs available for children. There is also a kiosk, a small supermarket, a range of further shops, a TV room, and a public Internet terminal. Guests arriving on business may take advantage of the business centre, while younger visitors can let off steam in the play area. Room and laundry services as well as medical facilities complete the offerings.
The hotel is located near a lush tropical garden and has views over the runways of Don Muang airport, which lies around 2 km away.
The air-conditioned rooms come with an en suite bathroom with hairdryer, a direct dial telephone, satellite/ cable TV, a radio, a minibar/ fridge, and a king-size bed.
There is a large swimming pool in the hotel's well-maintained outdoor complex. Additionally, guests may make use of the sauna, steam room, and Jacuzzi, or relax with a massage. Sports enthusiasts may work out in the gym.
Guests may select their breakfast and evening meals from buffet selections. Lunch and dinner may also be taken � la carte. Furthermore, special dietary requirements can be catered for as well as individual specific dishes prepared.
American Express, Diners Club, MasterCard and VISA are accepted as methods of payment.
Room Facilities:
Direct dial telephone
Satellite cable TV
HiFi stereo system
Internet access
King size bed


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The room was exactly like the pictures. I thought that the fridge had a freezer, so I was surprised that it didn't. I just assumed, so that was my error. we made breakfast and lunches in the room and ate out for dinners. It saved us money. We had plenty of towels and necessity supplies. One suggestion would be one King size bed instead of two double beds. It would give more room for maybe a built in countertop or full kitchen. We loved the internet access, very convienent. The Aloha staff (Kristen) was great, we called her several times for assistance with a broken lock and a lost key. she was very helpful and service oriented. she was great!!!!
· By Kauai happy from West Linn, Oregon on 10/29/2009 for a stay in October 2009 at
Two beds instead of one big one
Beach/Sun, Outdoor/Adventure,
Save money
Unless you know trails that you want to hike that 4wd is a necessity, then save money and just get a sedan. we were still able to rent a kayak and put it on our rental car. it was secure and safe and did no damage to the car.
My age: 35-44
My traveling group: spouse
"I probably would recommend this accommodation to my best friend!"
Young singles: No Opinion
Friends getaway: Yes
Large Groups: No Opinion
People with disabilities: No Opinion
Older travelers: No Opinion
Rugged travelers: Yes
Luxury-minded travelers: No Opinion
Families with young children: No Opinion
Families with teenagers: No Opinion
Tourists: No Opinion


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The World Poker Tour (WPT) broke its own record this week when the World Championship event began on April 18 with a field of 605 players and a prize pool of $15,125,000. First place winner will be awarded a record $3.7 million, while places 2-4 will receive payouts exceeding $1 million.
The $25,500 buy-in tournament at Las Vegas' Bellagio Hotel & Casino has attracted players from nearly 40 countries. The incentive for players is two-fold: to win the coveted WPT World Champion title and to go home with a portion of the record prize money, which will be split between spots 1-100.
"The WPT World Championship is considered the toughest tournament in the world to win if you consider the caliber of the competitors," says Steve Lipscomb, founder and CEO of WPT Enterprises, Inc. "At a cost of $25,500 to get to the table, you have to be a very accomplished poker player. You've either built a very solid bankroll or you've outlasted thousands in satellite tournaments. No doubt this final table will be a cliffhanger."
The WPT World Championship crowns the WPT's fourth season, bringing the total prize money for the 17 tournaments to $85,120,000. The tournaments currently airing on the Travel Channel every Wednesday night at 9 p.m. have revealed the 20 newest WPT Poker Millionaires.
Pro players who took to the WPT World Championship tables include defending champions Freddy Deeb, Michael Gracz, John D'Agostino, Hasan Habib, Scott Fischman, Martin de Knijff, Gus Hansen, David Benyamine, Juha Helppi, Chris Bigler, Humberto Brenes, Carlos Mortensen, Johan Storakers, Marcel Luske, Dave Ulliott, John Gale, and Patrik Antonius, among others.
Final table play will begin Monday, April 24, at 4 pm. The field of hopefuls will have been whittled down to six and from those six one will take home the $3,760,165 first prize. Second place will pay $1,903,950 and third place will pay $1,025,205.


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Everyone has a part to play… ERASE Bullying. www.erasebullying.ca
The BC Lions Football Club will continue their Huddle Up Against Bullying campaign in 2016, partenering with the Province of British Columbia, Intact Insurance, UNIGLOBE One Travel and C&D Logistics.
As part of a number of Lions community initiatives, the Huddle Up Against Bullying program will focus on delivering anti-bullying messaging to children ages 6 to 13 through the club's popular amateur football programs such as Play with the Pros and Punt, Pass and Kick.
"British Columbians are painfully aware of the devastating results of bullying, and our government is proud to support this effort through a $40,000 grant," said Minister of Community, Sport and Cultural Development Coralee Oakes. "The BC Lions are community leaders who are well-positioned to lead the charge against bullying by empowering kids to speak out against it."
"We are very pleased to add Huddle Up Against Bullying to our roster of Lions community programs" said Lions director of community relations Jamie Taras. "Bullying is a very serious and prevalent issue for today's youth and we are proud to do our part to educate young people about the consequences of this behavior while equipping them with tools to lessen its impact."
"UNIGLOBE One Travel is extremely proud to be involved as a partner in the Huddle Up Against Bullying program with the BC Lions. In today's society, many teens and others are subject to cruel and unfair treatment by many their own age because of the obscurity of the internet and social media," said Neal Chark, Senior Travel Consultant. "We hope that by bringing this issue to the forefront, we can be a part in changing this trend."
"We are so excited to be partnering with the BC Lions," said Luisa Currie, Vice-President of sales and business development, Western Division, Intact Insurance. "Their Huddle Up Anti-Bullying Campaign aligns with our core values and we're proud to stand by another team that supports respect, integrity and social responsibility. Both our organizations believe in leading by example and a partnership between two teams that support the same message is a win-win."
"C&D Logistics is pleased to team up with the BC Lions' Huddle Up Against Bullying campaign," said Dana Matheson, President of C&D Logistics. "Bullying is very prevalent amongst children in our community, especially online, and it's something that is very close to my heart. The Lions can count on C&D Logistics to be a great teammate in this wonderful endeavour to put an end to bullying."
For more information on the program or to book a team visit, please contact Tyler Gammon at firstname.lastname@example.com


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Sources said that mobile tower locations and telephonic details of Singh and the main accused, Anoop Singh Kahlon, gave ample evidence that the pugilist indeed was hooked to drugs and often visited the latter's house at Zirakpur. It was also said that Singh had went to Zirakpur flat twice, in December and February, especially for the heroin and returned within hours.
Police claimed that Singh kept in touch with Kahlon through mobile and also talked to him during his training camp from the National Institute of Sports.
OneIndia News


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Now Viewing:
Product Highlights
The Premier Mounts Ultra-Short-Throw Projector Wall Mount with SPIW includes an universal SpiroLock Projector mount and is designed to hold projectors weighing up to 45 lb (20.41 kg). Suitable for rooms where ceiling installation is not possible, the mount extends the projector by 6.5" (16.5 cm) to 18" (45.7 cm) from the wall and can be easily mounted using dual wood studs at 16" (40.6 cm), 18" (45.7 cm) and 24" (60.9 cm) spacings.
The GearBox (wall plate) of the wall mount can house an amplifier and other AV equipments and is secured by Lock-it security hardware. With mounting points at the top and bottom of the wall plate, the mount can also be installed off-center from the whiteboard or screen. Cables that route signals and power are concealed in the arm of the mount to eliminate cable clutter.
Multiple mounting slots for legs in the SpiroLock Projector mount give a variety of projector mounting options. Furthermore, the universal mounting legs are compatible with a variety of projectors. The mount lets you precisely adjust yaw, pitch, and roll without the need for special tools. The Radial Glide Technology allows up to 6º of smooth adjustment in any direction and the security screws and leveling barrel secure the projector.
|Weight Capacity
|45 lb (20.41 kg)
|Mounting Reach
|17.25" (438.15 mm)
|Packaging Infocqtrxqyxwwdrdsuwzzxbersaxerywaz
|Package Weight
|37.0 lb


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Prepay Utility Billing
While the deployment of advanced metering infrastructure (AMI) continues in energy and water markets globally, many utilities are maintaining investments in prepay metering as a key tool for debt management and revenue protection strategies.
Prepay metering infrastructures can be deployed in many different ways with utilities adopting a variety of communication and metering technologies based on regional topography and customer payment profiles. Gentrack Velocity is designed to support a multitude of prepay metering and communication technologies – providing the flexibility to integrate these technologies with enterprise systems for billing, customer management and prepay revenue management.
Gentrack's prepay billing engine and integrated workflow management tools called WIZARDS, ensure all activities relating to consumption and payment data collection, processing and storing are streamlined and automated where possible. Accurate tracking and receipting of payments from customers is key to maintaining a reliable and resilient prepay metering service.
For more information on Gentrack's prepay billing solution request a brochure here.
Configurable process flows and business logic streamline prepay billing, CRM and revenue collection activities
Prepay Meter Ready
Proven Prepay billing solution used in competitive and regulated energy markets -offering real-time payment acknowledgement
Supports multiple metering and communication technologies
Smart Integration
Webservices supports strong integration and streamlined data exchange with other enterprise applications, online self-service portals and third party prepay agencies
An intuitive web-browser user interface minimises training and ensures a strong user experience
Low Costs to Serve
Streamlined transaction billing activities in conjunction with configurable business rules achieve back office efficiency and lower costs to serve
Proven in the Cloud
Gentrack Velocity's Prepay billing solution is currently being delivered in The Cloud
Innovative Tools
Engage with non-paying customers via prepay technologies and tariffs for greater revenue protection.


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You're most likely familiar with how to recycle lots of basics in your kitchen: plastic bottles, glass jars, aluminum cans and the like. Go beyond the norm, take a look and find out how to make your kitchen greener with this list of recyclables that may not be on your recycling radar.
Feature image courtesy of Chalon Handmade
Latest posts by Kathryn Sukalich (see all)
- Everything You Need to Know About Paper Recycling - July 1, 2016
- Clean Your Whole House With Vinegar, Baking Soda And Lemon - June 15, 2016
- Simple Steps to Recycle Your Own Paper - June 10, 2016


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What our clients say about us
- "Fusion Speech was a good choice for West Georgia Health because it allowed us to use backend, frontend, and integrated voice recognition to meet the varying needs of our physicians. This was significant because it allowed for variations in physician practice patterns which helped with our overall adoption of the product."Sonya Christian, MBA, CHCIO, CPHIMS Chief Information OfficerWest Georgia Health, LaGrange, GA
- "The charts are completed the same day the patient is treated. I talk pretty fast and Dolbey keeps up with me. It has streamlined the way I document. I no longer have charting to do at the end of the day."Dr. Michael D. Bono, General Surgery, Board CertifiedHazleton General Hospital, Hazleton, PA
- "I have been utilizing Dolbey's Fusion Expert with our PACS system for over four years. This voice recognition system has helped us make significant improvements in our report turnaround times. Especially true in the Emergency Room, Fusion Expert has helped improve patient through put times. I have always self-edited all my reports, and with using Fusion Expert, it has been several years since I have sent a single report to transcription. I am very happy to work with the Dolbey Voice Recognition system."Evelio A. Alvarez M.D., Medical Director, Radiology DepartmentWestside Regional Medical Center, Plantation, FL
- "Since we installed Fusion Expert in June 2011, our report turnaround time has dramatically decreased. We are now providing near real-time final reporting during the day for inpatients, outpatients and ER patients. Most of our radiologists are using front-end self-editing tools, and we have found that after a short learning curve, their productivity returns to normal. The accuracy of the system is fantastic and the creation of templates and macros has facilitated an improved workflow. I am a first time VR user and I am very pleased with the Fusion Expert system. Our referring physicians appreciate the quick report turnaround time and the hospitals cost savings for transcription services is significant. Overall, Dolbey's Fusion Expert has exceeded our expectations and implementation was relatively painless."Martin L. Schwartz, MD, FACR Chairman, RadiologySaint Vincent's Health System, Birmingham, AL
- "Dolbey has proven to be a company who is enthusiastic about the product they are providing as well as being consistent with their approach. The sales team's professionalism is outstanding and demonstrates their willingness to provide the highest level of support. Dolbey provides resources without hesitation and is committed to building a long term relationship with our organization as well as our community. Munroe Regional Medical Center recognizes Dolbey as a reliable business partner and looks forward to continuing to build on this relationship."Carl Candullo Jr., Vice President and Chief Information OfficerMunroe Regional Medical Center, Ocala, FL
- "At Tristan, we have experienced many great benefits from utilizing Dolbey's Fusion Expert voice recognition system. Fusion Expert has greatly improved the efficiency of our radiologists and has reduced report turnaround time down to a matter of minutes. In turn, this has helped to improve our relationships with our referring physicians as they are beyond pleased to receive accurate reports so quickly. The entire process facilitates more timely patient care, which is what we strive to achieve."Brian Bloom M.D., Medical Director, Radiology DepartmentTristan Associates, Harrisburg, PA


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Citrus Lunch and Learn - January 14th
Leland Management
Tuesday, January 14, 2014 from 12:00 PM to 1:30 PM (EST)
Who's Going
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Sara Haughty
San Francisco, California
San Francisco, California
Luke Picard
London, United Kingdom
London, United Kingdom
Rick Vespucio
Florence, Italy
Florence, Italy
Event Details
Have questions about Citrus Lunch and Learn - January 14th? Contact Leland Management
When & Where
Leland Management Citrus Office
2720 W. Woodview Lane
Tuesday, January 14, 2014 from 12:00 PM to 1:30 PM (EST)
Add to my calendar
Leland Management
Leland Management is a full service community association management company that offers complete support to Homeowner and Condominium associations throughout Florida.
Citrus Lunch and Learn - January 14th
Things to do in Lecanto, FL


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US STOCKS-Wall St ends near flat; Dow hits record for 4th day
* S&P 500 breaks string of record high closes
* Dow ends at record high for 4th session
* Achillion Pharmaceuticals soars in heavy volume
* Dow up 0.02 pct, S&P 500 down 0.02 pct, Nasdaq up 0.04 pct (Updates to close)
By Caroline Valetkevitch
NEW YORK, June 10 (Reuters) - U.S. stocks finished nearly flat on Tuesday, although the Dow eked out another record closing high as utilities' shares fell while 10-year bond yields hit their highest level in a month.
Six of the 10 primary S&P 500 sector indexes ended the session lower. The decline was led by a 0.3 percent drop in the S&P utilities index. Utility stocks' high dividends tend to lose some of their appeal when bond yields jump.
It was the Dow's fourth straight record closing high. The S&P 500, though, broke its four-day string of record high finishes.
The benchmark S&P 500 moved within less than a 7-point range, continuing its recent tight trading pattern. Continuación...


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The Roc de Péclet residence is situated in the calm slalom area at the top of resort just next to the ESF mini club. Péclet commercial centre easily accessible (within 200m) and access to the pistes at just 20m from the building. Residence without a lift. Resort map n° 14/H2...
South facing 2 roomed apartment of 48m² with balcony. 3rd floor from building entrance.
Kitchenette with oven, microwaves, kitchen hobs, refrigerator and dishwasher. Dining area.
Bathroom with bath. Separate toilet.
Bedroom with two single beds.
Alcove with 2 bunkbeds.
Living room with sofa bed (DBL bed).
Resort WIFI network payable on condition that apartment has sufficient coverage.
Join us on Facebook :


text: Is It Game Over For Balotelli After Controversial Instagram Post? Timely Warning To Businesses Regarding Social Media Policies 02.12.2014 David Shirt, Press Officer | 0161 838 3094 Liverpool FC forward Mario Balotelli's alleged anti-Semitic and racist Instagram post could see him face a claim from Nintendo for both copyright and trade mark infringement, says leading national law firm Irwin Mitchell. Balotelli has deleted the post, which contained Nintendo computer game character Super Mario, and since then both his club and the FA have confirmed that they are looking into the matter. Under the FA's social media guidelines, the minimum ban for race-related breaches of rules is five games. The law firm says that in addition to being fined by his club and the FA, unless he has Nintendo's permission to use the image of Super Mario, he may be liable for copyright and trade mark infringement. Georgie Collins at the London office of Irwin Mitchell said: Expert OpinionThe use of Nintendo's image for these purposes could get him into hot water for both copyright and trade mark infringement, especially given the content which could be said to bring Nintendo's rights into disrepute or be denigrated." Georgie Collins, Partner The Liverpool striker is not the first footballer to get into trouble from using social media. In 2012, former England defender Rio Ferdinand was fined £45,000 and found guilty of improper conduct for a tweet he sent about Ashley Cole. In addition to the intellectual property issues that are at stake, employment lawyers from the firm have highlighted the importance for employers to remind employees about the dangers of social media. Omer Simjee, an employment Partner from Irwin Mitchell, said: Expert OpinionIt is absolutely vital that employers, including football clubs, provide guidance and clear policies on the use of such platforms which will give workers and their representatives a comprehensive understanding of what they can and cannot say via electronic communications. "Employers should look to fully highlight to staff how seriously any abuse of platforms is viewed so that workers understand that if they overstep the mark there could be significant consequences. Even if comments are made outside of work and on personal accounts, it can be a disciplinary matter and this needs to be understood by workers. For example, this can be the case where the entries on social media relate to issues affecting colleagues or pose a reputational risk for the employer. "An absolute must is that every complaint or matter which arises as a result of the use of social media or electronic communication should be dealt with in a consistent manner. Acting leniently in one case then more strictly in another can only leave employers open to potential legal action. "If Balotelli was an employee of one of our clients, we would be advising the employer to take disciplinary action in this matter." Omer Simjee, Partner Key contact Georgie Collins Partner +44 (0)787 625 3304 Email Georgie Press contact David Shirt BLS PR Manager 0161 838 3094 Email David Tags Services for Businesses Intellectual Property Georgie Collins Omer Simjee Related articles 20.06.2017Irwin Mitchell advises on £8m fundraising for K3 Business Technology Group 20.06.2017Irwin Mitchell Lawyer Addresses International Audience On New Data Rules 16.06.2017Irwin Mitchell Advise On Award Winning Deal 12.06.2017W.S. Darley & Co Acquires Fireboy Xintex In Poole 09.06.2017Election 2017: Planning Policy and Possible Compromise


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Frank Lloyd Wright: Waterlilies Umbrella
Our Price: $37.99
Free Shipping on orders of $59 or more Details >
Item No.: WLUM501
The graceful geometric pattern of flowers and lily pads floating on a tranquil pool is adapted from an unrealized art-glass screen designed by Wright.More >
AVAILABILITY: In Stock, leaves warehouse in 1 - 2 full bus. days Details >


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Thought Leadership
Transferring Family Wealth? Consider a Family Limited Partnership
A family limited partnership offers many perks, including the ability to transfer wealth at substantial discounts from the fair market value of underlying assets. But without a valuation, this perk easily could become a liability. A family limited partnership (FLP) is often regarded as a tax-advantageous vehicle for transferring wealth to future generations—one that allows you to retain control of your assets. Its most notable perk, however, may be the ability to transfer limited partner interests at substantial discounts to the partnership's underlying assets. In recent years these discounts have captured the IRS's attention, and, in light of controversial proposed regulations, could soon be on the chopping block. Having a valuation expert value the limited partner interests of your FLP could help to keep these discounts intact. Here are a few important things to know:
The basics of an FLP
Generally speaking, once you establish an FLP, you can contribute assets such as marketable securities, real estate, and private business interests in exchange for general and limited partner interests. Over time, you can gift, sell, or transfer these interests to family and non-family members, including charitable organizations. Because limited partnership interests do not allow for the control of day-to-day activities (lack of control) and could be difficult to sell (lack of marketability), they may be valued at a discount from the partnership's underlying assets. To qualify for valuation discounts, the FLP must have a legitimate business purpose, such as efficient asset management and protection from creditors. FLPs set up exclusively to minimize gift and estate taxes won't fly with the IRS.
The basics of valuing a limited partnership interest
Valuing a limited partnership interest typically starts with the partnership's net asset value, which is the combined fair market value of its assets on a controlling, marketable basis minus any liabilities. Business valuation experts then determine if discounts for lack of control and marketability apply to the partnership interests by analyzing the assets held by the partnership, the market, and restrictions placed on the ownership interests. The applicable discounts for lack of control and marketability are separate from one another and from discounts taken at the asset level (for instance, if discounts were taken on a private business interest that was contributed to the FLP). Combined, such discounts often reduce the value of a limited partnership interests by 40 percent or more. If you haven't properly documented and supported the discounts selected, they may not stand up to an IRS challenge. A professional valuation expert not only gives you a sound valuation of a limited partnership interest but he or she can also provide support and guidance if the IRS starts asking questions.
Considering an FLP? Talk to your attorney as soon as possible
In early December 2016, the IRS held a public hearing to discuss proposed regulations that would severely limit or remove discounts for certain family-owned business entities, including FLPs. Currently, it is unknown if the proposed regulations will be adopted, modified, or abandoned. Nevertheless, if you're considering an FLP, now is the time to act. Talk to your attorney to get started, and look to your tax advisor or valuation expert to learn more about the potential financial consequences.
For more information go to: www.dsb-cpa.com/business-valuation
Dan Korsman (J.D., CPA/ABV) is a Value Specialist with DS+B CPAs + Business Advisors. He has extensive experience in performing valuations for financial reporting purposes (business combinations, goodwill impairment and compensation expense) and for taxation purposes. He also performs valuation and litigation services for shareholder disputes, buy-sell agreements, divorces, succession planning and calculating damages.


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The garden that grows on this Lattice is made up of silicon. Lattice Semiconductor is a top developer of programmable logic devices (PLDs), including in-system programmable (ISP) devices that manufacturers configure and reconfigure once the chips are attached to a printed circuit board. Lattice also makes low-density logic devices and sells software – more... used to customize its chips, which are used in communications, computing, industrial, consumer, and automotive applications. The fabless chipmaker has expanded into the market for field-programmable gate arrays (FPGAs), another type of programmable chip. More than 85% of sales comes from outside the US, primarily from the Asia/Pacific region.
Lattice Semiconductor sells primarily through distributors: Arrow Electronics and its Nu Horizons Electronics subsidiary (combined, 22% of sales), Avnet (17%), and Weikeng (14%). The company's relationship with Avnet terminated in mid-2011; the companies agreed to terms of an inventory transition that would minimize disruption to customers. Lattice Semiconductor also sells directly through a network of sales representatives, and uses direct sales management and a field applications engineering organization to provide end-user and indirect sales support.
Year-over-year sales in 2011 were up 7% to $318 million, after rising more than 50% in 2010, and the company's net income increased by more than a third for the year. In 2010 Lattice Semiconductor reported profits for the first time since 2006. Sales improved across all end markets other than its largest (communications) and all but its mainstream product line. The improvements were primarily a result of increased unit sales. New product sales were up 16% for the year, after pulling in a more than 90% increase in 2010. However, increased sales volumes related to mature and mainstream products -- which carry a higher gross margin than new product lines -- were strong contributors to improvements in the company's bottom line. Gross margin increases when sales for a product are high compared to the cost associated with producing the product.
The company also touts lower costs achieved through restructuring and improvements in its distribution channels for improved results. A 2011 restructuring plan further reduced and refocused its workforce, streamlined supply chain activities at its headquarters, and moved certain development capabilities and logistics activities to the Philippines.
Lattice Semiconductor continues to conduct most of its product development work in the US, through facilities in California, Illinois, Oregon, and Pennsylvania. It also has development centers in China, India, and the Philippines, and operational centers in the Philippines and Singapore. In 2010 the company expanded its presence in India by establishing a sales and support facility to support rapid growth in the country.
Lattice Semiconductor is dependent to a large extent on the communications market, and on demand from telecommunications equipment manufacturers. The company gets more than 40% of sales from makers of communications equipment, lower than in prior years but . In addition, its low-power products are used in smartphones, GPS devices, and digital cameras, segments of the communications market that the company has not served before.
The fabless semiconductor company uses contract manufacturers to produce its wafers. Fujitsu Semiconductor makes most of the company's new products. Other chip makers that produce devices for Lattice on a contract basis include GLOBALFOUNDRIES, Seiko Epson, and United Microelectronics. Lattice Semiconductor added production capability through Taiwan Semiconductor Manufacturing Company with its acquisition of SiliconBlue.
Lattice Semiconductor looks for growth through acquisitions that complement existing product lines, expand market reach, and increase technological capabilities. In 2012 the company paid about $62 million for SiliconBlue Technologies, which provides FPGA devices for the consumer handheld industry. SiliconBlue's devices let mobile designers quickly add features to their mobile platform, primarily in the areas of connectivity, memory, storage, sensors, imaging, and video.
In 2011 Lattice Semiconductor acquired Hong Kong-based Rise Technology Development Company and its Philippine-based subsidiary APAC IC Layout Consultants, which provides engineering layout and design services. The purchase of Rise and APAC IC was part of an effort by Lattice to improve its research and development capabilities while reducing related costs. APAC IC added a development center in the Philippines, where labor costs are lower. – less
3 salaries reported
$132,364 per year


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