text:
Initial treatment of advanced stage diffuse large B cell lymphoma
- Authors
- Arnold S Freedman, MD
Arnold S Freedman, MD
- Section Editor — Lymphoproliferative Disorders
- Professor of Medicine
- Harvard Medical School
- Jonathan W Friedberg, MD
Jonathan W Friedberg, MD
- Professor of Medicine
- James P Wilmot Cancer Center, University of Rochester
- Section Editor
- Andrew Lister, MD, FRCP, FRCPath, FRCR
Andrew Lister, MD, FRCP, FRCPath, FRCR
- Section Editor — Lymphoproliferative Disorders
- Professor of Medical Oncology
- St. Bartholomew's Hospital, London
- Deputy Editor
- Alan G Rosmarin, MD
Alan G Rosmarin, MD
- Deputy Editor — Hematology
- Professor of Medicine
- University of Massachusetts Medical School
Diffuse large B cell lymphoma (DLBCL) is the most common histologic subtype of non-Hodgkin lymphoma (NHL), accounting for approximately 30 percent of patients with NHL [1]. It is an aggressive NHL in which survival without treatment is measured in months. (See "Classification of the hematopoietic neoplasms".)
The initial treatment of DLBCL is dependent upon the extent of disease (table 1). For treatment purposes, patients with DLBCL are generally classified as having either limited stage disease or advanced stage disease based upon whether or not the tumor can be contained within one irradiation field:
●Limited stage disease (usually Ann Arbor stage I or II) – Limited stage DLBCL can be contained within one irradiation field. This population accounts for 30 to 40 percent of patients with DLBCL. Limited stage DLBCL is treated primarily with combined modality therapy consisting of abbreviated systemic chemotherapy (three cycles), the recombinant anti-CD20 antibody rituximab, and involved field radiation therapy. Alternatively, full course (six to eight cycles) systemic chemotherapy plus rituximab without radiation therapy may be used. (See "Initial treatment of limited stage diffuse large B cell lymphoma".)
●Advanced stage disease (usually Ann Arbor stage III or IV) – Advanced stage DLBCL cannot be contained within one irradiation field. This population accounts for 60 to 70 percent of patients with DLBCL. Advanced stage DLBCL is treated primarily with systemic chemotherapy plus the recombinant anti-CD20 antibody rituximab.
Patients with bulky (>10 cm) stage II disease and patients with stage IIB disease have a less favorable prognosis than those with non-bulky stage II disease without systemic B symptoms. Many clinicians treat such patients in a similar fashion to those with advanced stage disease. (See "Initial treatment of limited stage diffuse large B cell lymphoma", section on 'Bulky disease'.)
Subscribers log in hereTo continue reading this article, you must log in with your personal, hospital, or group practice subscription. For more information or to purchase a personal subscription, click below on the option that best describes you:Literature review current through: May 2017. | This topic last updated: Apr 07, 2017.The content on the UpToDate website is not intended nor recommended as a substitute for medical advice, diagnosis, or treatment. Always seek the advice of your own physician or other qualified health care professional regarding any medical questions or conditions. The use of this website is governed by the UpToDate Terms of Use ©2017 UpToDate, Inc.References
- Swerdlow SH, Campo E, Harris NL, et al. (Eds). World Health Organization Classification of Tumours of Haematopoietic and Lymphoid Tissues, IARC Press, Lyon 2008.
- Khan AB, Barrington SF, Mikhaeel NG, et al. PET-CT staging of DLBCL accurately identifies and provides new insight into the clinical significance of bone marrow involvement. Blood 2013; 122:61.
- Sehn LH, Scott DW, Chhanabhai M, et al. Impact of concordant and discordant bone marrow involvement on outcome in diffuse large B-cell lymphoma treated with R-CHOP. J Clin Oncol 2011; 29:1452.
- Cheson BD, Fisher RI, Barrington SF, et al. Recommendations for initial evaluation, staging, and response assessment of Hodgkin and non-Hodgkin lymphoma: the Lugano classification. J Clin Oncol 2014; 32:3059.
- Sehn LH, Donaldson J, Chhanabhai M, et al. Introduction of combined CHOP plus rituximab therapy dramatically improved outcome of diffuse large B-cell lymphoma in British Columbia. J Clin Oncol 2005; 23:5027.
- Pettengell R, Linch D, Haemato-Oncology Task Force of the British Committee for Standards in Haematology. Position paper on the therapeutic use of rituximab in CD20-positive diffuse large B-cell non-Hodgkin's lymphoma. Br J Haematol 2003; 121:44.
- Coiffier B, Lepage E, Briere J, et al. CHOP chemotherapy plus rituximab compared with CHOP alone in elderly patients with diffuse large-B-cell lymphoma. N Engl J Med 2002; 346:235.
- Feugier P, Van Hoof A, Sebban C, et al. Long-term results of the R-CHOP study in the treatment of elderly patients with diffuse large B-cell lymphoma: a study by the Groupe d'Etude des Lymphomes de l'Adulte. J Clin Oncol 2005; 23:4117.
- Habermann TM, Weller EA, Morrison VA, et al. Rituximab-CHOP versus CHOP alone or with maintenance rituximab in older patients with diffuse large B-cell lymphoma. J Clin Oncol 2006; 24:3121.
- Pfreundschuh M, Schubert J, Ziepert M, et al. Six versus eight cycles of bi-weekly CHOP-14 with or without rituximab in elderly patients with aggressive CD20+ B-cell lymphomas: a randomised controlled trial (RICOVER-60). Lancet Oncol 2008; 9:105.
- Coiffier B, Thieblemont C, Van Den Neste E, et al. Long-term outcome of patients in the LNH-98.5 trial, the first randomized study comparing rituximab-CHOP to standard CHOP chemotherapy in DLBCL patients: a study by the Groupe d'Etudes des Lymphomes de l'Adulte. Blood 2010; 116:2040.
- Pfreundschuh M, Trümper L, Osterborg A, et al. CHOP-like chemotherapy plus rituximab versus CHOP-like chemotherapy alone in young patients with good-prognosis diffuse large-B-cell lymphoma: a randomised controlled trial by the MabThera International Trial (MInT) Group. Lancet Oncol 2006; 7:379.
- Pfreundschuh M, Kuhnt E, Trümper L, et al. CHOP-like chemotherapy with or without rituximab in young patients with good-prognosis diffuse large-B-cell lymphoma: 6-year results of an open-label randomised study of the MabThera International Trial (MInT) Group. Lancet Oncol 2011; 12:1013.
- Björkholm M, Andersson T, Ahlbom A, Ösby E. CNOP (mitoxantrone) chemotherapy is inferior to CHOP (doxorubicin) in the treatment of patients with aggressive non-Hodgkin lymphoma (meta-analysis). Eur J Haematol 2008; 80:477.
- Gaynor ER, Unger JM, Miller TP, et al. Infusional CHOP chemotherapy (CVAD) with or without chemosensitizers offers no advantage over standard CHOP therapy in the treatment of lymphoma: a Southwest Oncology Group Study. J Clin Oncol 2001; 19:750.
- Bartlett NL, Petroni GR, Parker BA, et al. Dose-escalated cyclophosphamide, doxorubicin, vincristine, prednisone, and etoposide (CHOPE) chemotherapy for patients with diffuse lymphoma: Cancer and Leukemia Group B studies 8852 and 8854. Cancer 2001; 92:207.
- Sparano JA, Weller E, Nazeer T, et al. Phase 2 trial of infusional cyclophosphamide, doxorubicin, and etoposide in patients with poor-prognosis, intermediate-grade non-Hodgkin lymphoma: an Eastern Cooperative Oncology Group trial (E3493). Blood 2002; 100:1634.
- Burton C, Smith P, Vaughan-Hudson G, et al. Comparison of CHOP versus CIOP in good prognosis younger patients with histologically aggressive non-Hodgkin lymphoma. Br J Haematol 2005; 130:536.
- Scott DW, Mottok A, Ennishi D, et al. Prognostic Significance of Diffuse Large B-Cell Lymphoma Cell of Origin Determined by Digital Gene Expression in Formalin-Fixed Paraffin-Embedded Tissue Biopsies. J Clin Oncol 2015; 33:2848.
- Johnson NA, Slack GW, Savage KJ, et al. Concurrent expression of MYC and BCL2 in diffuse large B-cell lymphoma treated with rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone. J Clin Oncol 2012; 30:3452.
- Green TM, Young KH, Visco C, et al. Immunohistochemical double-hit score is a strong predictor of outcome in patients with diffuse large B-cell lymphoma treated with rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone. J Clin Oncol 2012; 30:3460.
- Hu S, Xu-Monette ZY, Tzankov A, et al. MYC/BCL2 protein coexpression contributes to the inferior survival of activated B-cell subtype of diffuse large B-cell lymphoma and demonstrates high-risk gene expression signatures: a report from The International DLBCL Rituximab-CHOP Consortium Program. Blood 2013; 121:4021.
- Mareschal S, Lanic H, Ruminy P, et al. The proportion of activated B-cell like subtype among de novo diffuse large B-cell lymphoma increases with age. Haematologica 2011; 96:1888.
- Rueda A, Sabin P, Rifá J, et al. R-CHOP-14 in patients with diffuse large B-cell lymphoma younger than 70 years: a multicentre, prospective study. Hematol Oncol 2008; 26:27.
- Economopoulos T, Psyrri A, Dimopoulos MA, et al. CEOP-21 versus CEOP-14 chemotherapy with or without rituximab for the first-line treatment of patients with aggressive lymphomas: results of the HE22A99 trial of the Hellenic Cooperative Oncology Group. Cancer J 2007; 13:327.
- Cunningham D, Hawkes EA, Jack A, et al. Rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisolone in patients with newly diagnosed diffuse large B-cell non-Hodgkin lymphoma: a phase 3 comparison of dose intensification with 14-day versus 21-day cycles. Lancet 2013; 381:1817.
- Delarue R, Tilly H, Mounier N, et al. Dose-dense rituximab-CHOP compared with standard rituximab-CHOP in elderly patients with diffuse large B-cell lymphoma (the LNH03-6B study): a randomised phase 3 trial. Lancet Oncol 2013; 14:525.
- Kamel S, O'Connor S, Lee N, et al. High incidence of Pneumocystis jirovecii pneumonia in patients receiving biweekly rituximab and cyclophosphamide, adriamycin, vincristine, and prednisone. Leuk Lymphoma 2010; 51:797.
- Safar, V, Dupuis, J, Jardin, F, et al. Early 18fluorodeoxyglucose PET Scan as a Prognostic Tool in Diffuse Large B-Cell Lymphoma Patients Treated with An Anthracycline-Based Chemotherapy Plus Rituximab. Blood 2009; 114:45 (abstr 98). (Available online at http://ash.confex.com/ash/2009/webprogram/Paper21587.html, accessed January 20, 2010).
- Pregno, P, Chiappella, A, Bellò, M, et al. Interim 18-FDG-Positron Emission Tomography/Computed Tomography (PET) Failed to Predict Different Outcome in Diffuse Large B-Cell Lymphoma (DLBCL) Patients Treated with Rituximab-CHOP. Blood 2009; 114:45 (abstr 99). (Available online at http://ash.confex.com/ash/2009/webprogram/Paper20694.html, accessed January 20, 2010).
- Morrison, VA, Weller, EAa, Habermann, TM, et al. Maintenance rituximab compared to observation after R-CHOP or CHOP in older patients with diffuse large B-cell lymphoma: An intergroup E4494/C9793 update (abstract). J Clin Oncol 2007; 25:8011.
- Greb A, Bohlius J, Schiefer D, et al. High-dose chemotherapy with autologous stem cell transplantation in the first line treatment of aggressive non-Hodgkin lymphoma (NHL) in adults. Cochrane Database Syst Rev 2008; :CD004024.
- Stiff PJ, Unger JM, Cook JR, et al. Autologous transplantation as consolidation for aggressive non-Hodgkin's lymphoma. N Engl J Med 2013; 369:1681.
- Cortelazzo S, Tarella C, Gianni AM, et al. Randomized Trial Comparing R-CHOP Versus High-Dose Sequential Chemotherapy in High-Risk Patients With Diffuse Large B-Cell Lymphomas. J Clin Oncol 2016; 34:4015.
- Glass B, Ziepert M, Reiser M, et al. High-dose therapy followed by autologous stem-cell transplantation with and without rituximab for primary treatment of high-risk diffuse large B-cell lymphoma. Ann Oncol 2010; 21:2255.
- Schmitz N, Nickelsen M, Ziepert M, et al. Conventional chemotherapy (CHOEP-14) with rituximab or high-dose chemotherapy (MegaCHOEP) with rituximab for young, high-risk patients with aggressive B-cell lymphoma: an open-label, randomised, phase 3 trial (DSHNHL 2002-1). Lancet Oncol 2012; 13:1250.
- Récher C, Coiffier B, Haioun C, et al. Intensified chemotherapy with ACVBP plus rituximab versus standard CHOP plus rituximab for the treatment of diffuse large B-cell lymphoma (LNH03-2B): an open-label randomised phase 3 trial. Lancet 2011; 378:1858.
- Molina TJ, Canioni D, Copie-Bergman C, et al. Young patients with non-germinal center B-cell-like diffuse large B-cell lymphoma benefit from intensified chemotherapy with ACVBP plus rituximab compared with CHOP plus rituximab: analysis of data from the Groupe d'Etudes des Lymphomes de l'Adulte/lymphoma study association phase III trial LNH 03-2B. J Clin Oncol 2014; 32:3996.
- Vitolo U, Chiappella A, Franceschetti S, et al. Lenalidomide plus R-CHOP21 in elderly patients with untreated diffuse large B-cell lymphoma: results of the REAL07 open-label, multicentre, phase 2 trial. Lancet Oncol 2014; 15:730.
- Nowakowski GS, LaPlant B, Macon WR, et al. Lenalidomide combined with R-CHOP overcomes negative prognostic impact of non-germinal center B-cell phenotype in newly diagnosed diffuse large B-Cell lymphoma: a phase II study. J Clin Oncol 2015; 33:251.
- Younes A, Thieblemont C, Morschhauser F, et al. Combination of ibrutinib with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) for treatment-naive patients with CD20-positive B-cell non-Hodgkin lymphoma: a non-randomised, phase 1b study. Lancet Oncol 2014; 15:1019.
- Monti S, Savage KJ, Kutok JL, et al. Molecular profiling of diffuse large B-cell lymphoma identifies robust subtypes including one characterized by host inflammatory response. Blood 2005; 105:1851.
- Ruan J, Martin P, Furman RR, et al. Bortezomib plus CHOP-rituximab for previously untreated diffuse large B-cell lymphoma and mantle cell lymphoma. J Clin Oncol 2011; 29:690.
- Offner F, Samoilova O, Osmanov E, et al. Frontline rituximab, cyclophosphamide, doxorubicin, and prednisone with bortezomib (VR-CAP) or vincristine (R-CHOP) for non-GCB DLBCL. Blood 2015; 126:1893.
- Swerdlow SH, Campo E, Pileri SA, et al. The 2016 revision of the World Health Organization classification of lymphoid neoplasms. Blood 2016; 127:2375.
- Sun H, Savage KJ, Karsan A, et al. Outcome of Patients With Non-Hodgkin Lymphomas With Concurrent MYC and BCL2 Rearrangements Treated With CODOX-M/IVAC With Rituximab Followed by Hematopoietic Stem Cell Transplantation. Clin Lymphoma Myeloma Leuk 2015; 15:341.
- Howlett C, Snedecor SJ, Landsburg DJ, et al. Front-line, dose-escalated immunochemotherapy is associated with a significant progression-free survival advantage in patients with double-hit lymphomas: a systematic review and meta-analysis. Br J Haematol 2015; 170:504.
- Petrich AM, Gandhi M, Jovanovic B, et al. Impact of induction regimen and stem cell transplantation on outcomes in double-hit lymphoma: a multicenter retrospective analysis. Blood 2014; 124:2354.
- Oki Y, Noorani M, Lin P, et al. Double hit lymphoma: the MD Anderson Cancer Center clinical experience. Br J Haematol 2014; 166:891.
- Dunleavy K, Fanale M, LaCasce A, et al. Preliminary Report of a Multicenter Prospective Phase II Study of DA-EPOCH-R in MYC-Rearranged Aggressive B-Cell Lymphoma (abstract 395). Blood 2014; 124:395.
- Nabhan C, Smith SM, Helenowski I, et al. Analysis of very elderly (≥80 years) non-hodgkin lymphoma: impact of functional status and co-morbidities on outcome. Br J Haematol 2012; 156:196.
- Thieblemont C, Coiffier B. Lymphoma in older patients. J Clin Oncol 2007; 25:1916.
- Tucci A, Ferrari S, Bottelli C, et al. A comprehensive geriatric assessment is more effective than clinical judgment to identify elderly diffuse large cell lymphoma patients who benefit from aggressive therapy. Cancer 2009; 115:4547.
- Fields PA, Linch DC. Treatment of the elderly patient with diffuse large B cell lymphoma. Br J Haematol 2012; 157:159.
- Lyman GH, Dale DC, Friedberg J, et al. Incidence and predictors of low chemotherapy dose-intensity in aggressive non-Hodgkin's lymphoma: a nationwide study. J Clin Oncol 2004; 22:4302.
- Tirelli U, Errante D, Van Glabbeke M, et al. CHOP is the standard regimen in patients > or = 70 years of age with intermediate-grade and high-grade non-Hodgkin's lymphoma: results of a randomized study of the European Organization for Research and Treatment of Cancer Lymphoma Cooperative Study Group. J Clin Oncol 1998; 16:27.
- Lee KW, Kim DY, Yun T, et al. Doxorubicin-based chemotherapy for diffuse large B-cell lymphoma in elderly patients: comparison of treatment outcomes between young and elderly patients and the significance of doxorubicin dosage. Cancer 2003; 98:2651.
- Kwak LW, Halpern J, Olshen RA, Horning SJ. Prognostic significance of actual dose intensity in diffuse large-cell lymphoma: results of a tree-structured survival analysis. J Clin Oncol 1990; 8:963.
- Pettengell R, Schwenkglenks M, Bosly A. Association of reduced relative dose intensity and survival in lymphoma patients receiving CHOP-21 chemotherapy. Ann Hematol 2008; 87:429.
- Williams JN, Rai A, Lipscomb J, et al. Disease characteristics, patterns of care, and survival in very elderly patients with diffuse large B-cell lymphoma. Cancer 2015; 121:1800.
- Pfreundschuh M, Müller C, Zeynalova S, et al. Suboptimal dosing of rituximab in male and female patients with DLBCL. Blood 2014; 123:640.
- Pfreundschuh M, Poeschel V, Zeynalova S, et al. Optimization of rituximab for the treatment of diffuse large B-cell lymphoma (II): extended rituximab exposure time in the SMARTE-R-CHOP-14 trial of the german high-grade non-Hodgkin lymphoma study group. J Clin Oncol 2014; 32:4127.
- Peyrade F, Jardin F, Thieblemont C, et al. Attenuated immunochemotherapy regimen (R-miniCHOP) in elderly patients older than 80 years with diffuse large B-cell lymphoma: a multicentre, single-arm, phase 2 trial. Lancet Oncol 2011; 12:460.
- Weidmann E, Neumann A, Fauth F, et al. Phase II study of bendamustine in combination with rituximab as first-line treatment in patients 80 years or older with aggressive B-cell lymphomas. Ann Oncol 2011; 22:1839.
- Meguro A, Ozaki K, Sato K, et al. Rituximab plus 70% cyclophosphamide, doxorubicin, vincristine and prednisone for Japanese patients with diffuse large B-cell lymphoma aged 70 years and older. Leuk Lymphoma 2012; 53:43.
- Merli F, Luminari S, Rossi G, et al. Cyclophosphamide, doxorubicin, vincristine, prednisone and rituximab versus epirubicin, cyclophosphamide, vinblastine, prednisone and rituximab for the initial treatment of elderly "fit" patients with diffuse large B-cell lymphoma: results from the ANZINTER3 trial of the Intergruppo Italiano Linfomi. Leuk Lymphoma 2012; 53:581.
- Trebouet A, Marchand T, Lemal R, et al. Lymphoma occurring in patients over 90 years of age: characteristics, outcomes, and prognostic factors. A retrospective analysis of 234 cases from the LYSA. Ann Oncol 2013; 24:2612.
- Hershman DL, McBride RB, Eisenberger A, et al. Doxorubicin, cardiac risk factors, and cardiac toxicity in elderly patients with diffuse B-cell non-Hodgkin's lymphoma. J Clin Oncol 2008; 26:3159.
- Luminari S, Montanini A, Caballero D, et al. Nonpegylated liposomal doxorubicin (MyocetTM) combination (R-COMP) chemotherapy in elderly patients with diffuse large B-cell lymphoma (DLBCL): results from the phase II EUR018 trial. Ann Oncol 2010; 21:1492.
- Fields PA, Townsend W, Webb A, et al. De novo treatment of diffuse large B-cell lymphoma with rituximab, cyclophosphamide, vincristine, gemcitabine, and prednisolone in patients with cardiac comorbidity: a United Kingdom National Cancer Research Institute trial. J Clin Oncol 2014; 32:282.
- Chao NJ, Rosenberg SA, Horning SJ. CEPP(B): an effective and well-tolerated regimen in poor-risk, aggressive non-Hodgkin's lymphoma. Blood 1990; 76:1293.
- Moccia AA, Schaff K, Hoskins P, et al. R-CHOP with Etoposide Substituted for Doxorubicin (R-CEOP): Excellent Outcome in Diffuse Large B Cell Lymphoma for Patients with a Contraindication to Anthracyclines (abstract 408). Blood 2009; 114:170.
- Shipp MA, Klatt MM, Yeap B, et al. Patterns of relapse in large-cell lymphoma patients with bulk disease: implications for the use of adjuvant radiation therapy. J Clin Oncol 1989; 7:613.
- Phan J, Mazloom A, Medeiros LJ, et al. Benefit of consolidative radiation therapy in patients with diffuse large B-cell lymphoma treated with R-CHOP chemotherapy. J Clin Oncol 2010; 28:4170.
- Dorth JA, Prosnitz LR, Broadwater G, et al. Impact of consolidation radiation therapy in stage III-IV diffuse large B-cell lymphoma with negative post-chemotherapy radiologic imaging. Int J Radiat Oncol Biol Phys 2012; 84:762.
- Shi Z, Das S, Okwan-Duodu D, et al. Patterns of failure in advanced stage diffuse large B-cell lymphoma patients after complete response to R-CHOP immunochemotherapy and the emerging role of consolidative radiation therapy. Int J Radiat Oncol Biol Phys 2013; 86:569.
- Dabaja BS, Vanderplas AM, Crosby-Thompson AL, et al. Radiation for diffuse large B-cell lymphoma in the rituximab era: analysis of the National Comprehensive Cancer Network lymphoma outcomes project. Cancer 2015; 121:1032.
- Held G, Murawski N, Ziepert M, et al. Role of radiotherapy to bulky disease in elderly patients with aggressive B-cell lymphoma. J Clin Oncol 2014; 32:1112.
- Rübe C, Nguyen TP, Klöss M, et al. Consolidation radiotherapy to bulky disease in aggressive NHL. First results of the NHL B-94 trial of the DSHNHL. Ann Hematol 2001; 80 Suppl 3:B84.
- Niitsu N, Okamoto M, Miura I, Hirano M. Clinical features and prognosis of de novo diffuse large B-cell lymphoma with t(14;18) and 8q24/c-MYC translocations. Leukemia 2009; 23:777.
- Aukema SM, Siebert R, Schuuring E, et al. Double-hit B-cell lymphomas. Blood 2011; 117:2319.
- Lin P, Dickason TJ, Fayad LE, et al. Prognostic value of MYC rearrangement in cases of B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and Burkitt lymphoma. Cancer 2012; 118:1566.
- Akyurek N, Uner A, Benekli M, Barista I. Prognostic significance of MYC, BCL2, and BCL6 rearrangements in patients with diffuse large B-cell lymphoma treated with cyclophosphamide, doxorubicin, vincristine, and prednisone plus rituximab. Cancer 2012; 118:4173.
- Perry AM, Crockett D, Dave BJ, et al. B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and burkitt lymphoma: study of 39 cases. Br J Haematol 2013; 162:40.
- Dunleavy K, Pittaluga S, Janik J, et al. Novel treatment of Burkitt lymphoma with dose-adjusted EPOCH-rituximab: preliminary results showing excellent outcome (abstract). Blood 2006;108:774A.
- Jermann M, Jost LM, Taverna Ch, et al. Rituximab-EPOCH, an effective salvage therapy for relapsed, refractory or transformed B-cell lymphomas: results of a phase II study. Ann Oncol 2004; 15:511.
- Juweid ME, Stroobants S, Hoekstra OS, et al. Use of positron emission tomography for response assessment of lymphoma: consensus of the Imaging Subcommittee of International Harmonization Project in Lymphoma. J Clin Oncol 2007; 25:571.
- Dorth JA, Chino JP, Prosnitz LR, et al. The impact of radiation therapy in patients with diffuse large B-cell lymphoma with positive post-chemotherapy FDG-PET or gallium-67 scans. Ann Oncol 2011; 22:405.
- Horning SJ, Juweid ME, Schöder H, et al. Interim positron emission tomography scans in diffuse large B-cell lymphoma: an independent expert nuclear medicine evaluation of the Eastern Cooperative Oncology Group E3404 study. Blood 2010; 115:775.
- Larouche JF, Berger F, Chassagne-Clément C, et al. Lymphoma recurrence 5 years or later following diffuse large B-cell lymphoma: clinical characteristics and outcome. J Clin Oncol 2010; 28:2094.
- Maurer MJ, Ghesquières H, Jais JP, et al. Event-free survival at 24 months is a robust end point for disease-related outcome in diffuse large B-cell lymphoma treated with immunochemotherapy. J Clin Oncol 2014; 32:1066.
- Liedtke M, Hamlin PA, Moskowitz CH, Zelenetz AD. Surveillance imaging during remission identifies a group of patients with more favorable aggressive NHL at time of relapse: a retrospective analysis of a uniformly-treated patient population. Ann Oncol 2006; 17:909.
- El-Galaly TC, Mylam KJ, Bøgsted M, et al. Role of routine imaging in detecting recurrent lymphoma: A review of 258 patients with relapsed aggressive non-Hodgkin and Hodgkin lymphoma. Am J Hematol 2014; 89:575.
- Brenner DJ, Hall EJ. Computed tomography--an increasing source of radiation exposure. N Engl J Med 2007; 357:2277.
- Sodickson A, Baeyens PF, Andriole KP, et al. Recurrent CT, cumulative radiation exposure, and associated radiation-induced cancer risks from CT of adults. Radiology 2009; 251:175.
- Berrington de González A, Mahesh M, Kim KP, et al. Projected cancer risks from computed tomographic scans performed in the United States in 2007. Arch Intern Med 2009; 169:2071.
- Thompson CA, Ghesquieres H, Maurer MJ, et al. Utility of routine post-therapy surveillance imaging in diffuse large B-cell lymphoma. J Clin Oncol 2014; 32:3506.
- El-Galaly TC, Jakobsen LH, Hutchings M, et al. Routine Imaging for Diffuse Large B-Cell Lymphoma in First Complete Remission Does Not Improve Post-Treatment Survival: A Danish-Swedish Population-Based Study. J Clin Oncol 2015; 33:3993.
- Kurtz DM, Green MR, Bratman SV, et al. Noninvasive monitoring of diffuse large B-cell lymphoma by immunoglobulin high-throughput sequencing. Blood 2015; 125:3679.
- Armand P, Oki Y, Neuberg DS, et al. Detection of circulating tumour DNA in patients with aggressive B-cell non-Hodgkin lymphoma. Br J Haematol 2013; 163:123.
- Roschewski M, Dunleavy K, Pittaluga S, et al. Circulating tumour DNA and CT monitoring in patients with untreated diffuse large B-cell lymphoma: a correlative biomarker study. Lancet Oncol 2015; 16:541.
- Clinical assessment
- Identify disease subtype
- Assess need for CNS prophylaxis
- Overview of our approach
- - Targeting CD20
- - Molecular subtype-specific therapy
- - Adjunctive care
- Germinal center B cell type DLBCL
- - Choice of chemotherapy regimen
- - Number of treatment cycles
- - Is there a role for maintenance rituximab?
- - Is there a role for transplant?
- Activated B cell type DLBCL
- Double hit or double expressor DLBCL
- Older adults
- Patients with cardiac disease
- AIDS-related lymphoma
- Bulky disease
- DLBCL-Burkitt
- DLBCL-Hodgkin
- Response evaluation
- Surveillance for relapse
- Prognosis


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Fic: The Devil You Know - 1/1 - Jean, Logan (L/R/S/J)
Expand Messages
- Title: The Devil You Know
Author: Victoria P. [victoria_p@...]
Summary: "Better the devil you know than the devil you don't."
Rating: PG-13 - some imagery
Disclaimer: All X-Men characters belong to Marvel and Fox; this piece of
fan-written fiction intends no infringement on any copyrights.
Archive: Lists, Muse's Fool, otherwise, just let me know you're taking
Feedback: Makes me do the Snoopy Dance
Notes: Thanks to Dot, Meg, Jen, and Pete. And I guess, thanks to Depeche
Mode. Saw 'em in concert last night, and woke up with this, this
If anyone can find the attribution for the quote, I'd appreciate it. I
thought it was originally Shakespeare, but I can't find it...
{ } indicates POV
The Devil You Know
"Better the devil you know than the devil you don't."
When Logan came back, he made it clear that he wanted her. She stared
out the window, stealing a few moments to watch him as he mowed the
lawn, shirt off, muscles rippling.
She closed her eyes and imagined him pressing her against the wall,
wrapping her legs around his hips, taking her hard. She opened her eyes
with a gasp, worried that she'd been projecting.
She wondered what kept her tied safely to Scott. Love, yes. But also
She and Scott were settled, comfortable. Logan offered wildness -- lust,
sex, no commitment beyond the moment. Jean needed commitment. She needed
stability after years of being driven crazy by the voices in her head.
She was afraid that once they satisfied their desire for each other,
there would be nothing left, and they would drift aimlessly apart.
Better she stay with Scott, whom she loved, and fight the demons of
complacency and familiarity. Better the devil you know, she thought,
than the unknown dangers and eventual heartache of an affair with Logan.
She turned away from the window as Scott entered the room. "Let's go
upstairs," she said huskily, reaffirming her decision, her commitment to
this man who held first place in her heart, if not always in her
He wanted Jean. He'd never made a secret of it. When he came back, he
hugged the kid and, ignoring the hurt in her eyes, made straight for the
redheaded doctor.
He didn't let up on his pursuit, couching it in the friendly flirtation
he used on the other women at the mansion, but there was always a spark
in his eye that told everyone this was no game to him.
He spent more time with Rogue as the months passed, teaching her to
defend herself, and, though he didn't know it, teaching her more about
himself and the ways to his heart. Ways even he didn't know existed.
He found himself at her side after her nightmares, drawn by the
unbreakable bond between them. She was etched indelibly on his heart,
and he fought with every animal instinct in him to break free from her
hold on him.
He was afraid. In the darker moments of his sleepless nights, he could
admit that to himself. He had no past and, therefore, could conceive of
no future. He could make no more promises to the girl with the ancient
eyes, the girl who had possession of his very soul. He was afraid, and
he decided that lust, a heated affair with no commitments, was better
than this aching feeling he thought must be love.
Better the devil you know, he thought, and so he chose to act on lust,
and lock away the love he felt for Rogue. Better to hurt her this way,
when she could still get over it and move on, than to begin something he
was sure could only end badly.
He watched as she turned more and more to that new kid, Remy, and swore
that if the punk ever hurt her, he'd find himself face-to-claw with a
very angry Wolverine. He'd made a decision, and, judging from her
behavior with Remy, it was the right one. Now, if he could just figure
out why he no longer enjoyed flirting with Jean. If he could just figure
out why he had this pain in his chest that his healing factor apparently
couldn't touch.
"Screw the dead. What have their moldering asses ever done for me?" Mike
Kellerman, _Homicide: Life on the Street_
The Muse's Fool - http://www.unfitforsociety.net/musesfool
Unfit for Society - http://www.unfitforsociety.net
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text:
York police officer injured when boat falls on him
YORK, S.C. - A York police officer has serious injuries after a boat fell on top of him.
The Herald in Rock Hill reported Lance Cpl. Lee McClellan was working on the boat Tuesday with a friend when it slipped, pinning him for several minutes.
McClellan was off-duty at the time of the incident.
He was take to the intensive care unit at Carolinas Medical Center in Charlotte.


text:
The Passion of the Purple Plumeria
Please sign in to listen or upgrade to TuneIn Premium.
- United States
- Historical Fiction
- English
More informationNEVER BEFORE PUBLISHED!
Lauren Willig's Pink Carnation novels have been hailed as "sheer fun"* and "charming."** Now she takes readers on an adventure filled with hidden treasure and a devilishly handsome English colonel....
Colonel William Reid has returned home from India to retire near his children, who are safely stowed at an academy in Bath. Upon his return to the Isles, however, he finds that one of his daughters has vanished, along with one of her classmates.
Because she served as second-in-command to the Pink Carnation, one of England's most intrepid spies, it would be impossible for Gwendolyn Meadows to give up the intrigue of Paris for a quiet life in the English countryside-especially when she's just overheard news of an alliance forming between Napoleon and an Ottoman Sultan. But, when the Pink Carnation's little sister goes missing from her English boarding school, Gwen reluctantly returns home to investigate the girl's disappearance.
Thrown together by circumstance, Gwen and William must cooperate to track down the young ladies before others with nefarious intent get their hands on them. But Gwen's partnership with quick-tongued, roguish William may prove to be even more of an adventure for her than finding the lost girls….
*New York Times Bestselling Author Christina Dodd
**Kirkus Reviews


text:
Fatima is ranked number 12,047 in the overall artist rankings with a total rank score of 22.
Listen to Fatima on YouTube
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Fatima best albums
The following albums by Fatima are ranked highest in the greatest album charts:
|Yellow Memories
|Buy album Use the iTunes, Amazon or eBay buttons to safely buy this item from one of the world's top online stores.
|Overall band rank:
Total albums: 1. Page 1 of 1
This may not be a complete discography for Fatima. This listing only shows those albums by this artist that appear in at least one chart on this site. If an album is 'missing' that you think deserves to be here, you can include it in your own chart from the My Charts page!
Fatima ratings
Average Rating:
74/100 (from 1 vote)Average Rating = (n ÷ (n + m)) × av + (m ÷ (n + m)) × AV
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text:
Description of this paper
Sierra and Hannah went snowboarding at Mammoth last winter. On-(Answered)
Instant Solution ? Click "Buy button" to Download the solution File
Sierra and Hannah went snowboarding at Mammoth last winter. On the trip Sierra admired Hannah's snowboard, and told her so. Hannah told Sierra that she was going to buy a new snowboard in the summer and that Hannah would sell this board to Sierra for $300. Sierra agreed to buy the board. That August Hannah bought a new snowboard. She called Sierra and told her she was ready to complete the sale. Sierra responded by saying "What sale?" Hannah reminded Sierra of the conversation they had had that winter about Sierra buying Hannah's old snowboard. Sierra's response was "Oh, I was just admiring your board. I didn't want to buy it."
a. You be the jury. Do Sierra and Hannah have a contract?
b. Discuss the applicable law(s) and then apply the law(s) to the material facts in the problem. In discussing the law, describe each element of the law and the facts that apply to each element.
Paper#9209977 | Written in 27-Jul-2016Price : $22


text:
Enough said.
Now I need to add a fee words to make the two hundred character minimum.
Looking around I notice a shower cap covering the smoke alarm. Clever. Those things can be really irritating if the place catches on fire.
I had an interesting shower earlier. The water automatically fluctuated between scalding hot and freezing cold.
If I wasn't in a bad mood from the dirty toilet I would have to say I have happily stayed in worse places. It's not all bad but they could certainly try harder.
- Official Description (provided by the hotel):
- The Quality Hotel Manor offers boutique accommodation just 20 mins from Melbourne, a short drive from the Dandenong Ranges and Yarra Valley. We provide a 24-hour Reception, 24-hour room service and complimentary undercover parking. We boast 34 spacious suites and 2 executive spa suites, with contemporary decor and a variety of added features. We have a fully licensed Restaurant open 7 nights a week, conference facilities, as well as a 24 hour business centre. ... more less
- Reservation Options:
- TripAdvisor is proud to partner with Booking.com, Hotels.com, Agoda, Priceline, Expedia, Ebookers, TripOnline SA, Evoline ltd and HotelQuickly so you can book your Quality Hotel Manor reservations with confidence. We help millions of travellers each month to find the perfect hotel for both holiday and business trips, always with the best discounts and special offers.


text:
Stocks try to regain their footing, metals upDismiss Notice
Good Weds Morning! Gold is up 5.5 to 1252, while Silver is up 16 to 16.75. Crude is down 16 to 4408. The USD is down .09 to 9600Dismiss Notice
Week of 6/24/2017 Closing prices & Chg Over Last Wk---- Gold $1256.40 Silver $16.64 Oil $43.01 USD $96.94
"Spreading the ideas of freedom loving people on matters regarding high finance, politics, constructionist Constitution, and mental masturbation of all types"Dismiss Notice
All Things Automotive (Cars, Trucks, Etc.)
Discussion in 'Auto, Tractor, Motorcycles, Racing, and Mechanics' started by searcher, Jun 21, 2015.
Page 113 of 134
Page 113 of 134


text:
Metal: 18K yellow gold Marked/Tested KIESELSTEIN CORD, 1984, 750 Gemstones/Diamonds Diamonds, approx 0.42ctw Clarity: VS Color: G Measurements: Earrings - 19mm x 18mm ( 1 inch = 25mm) Weight 22.5g Description: Excellent condition!!
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My game compilation, haha. The reason I made this is I always make tiny, but fun games that aren't good enough to get a good score score on the portal alone, so I decided to see if I put them together in a fashionable way if they could somehow receive a better score than they would alone. I hope you like them!
I never realized
how hard it is to be a freakin goomba.
Cool games!
Sick of stick figure cartoons? Get ready for stick genocide!
The wonderful misadventures of MUNCH.
It's Nameless!
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text:
Electricity with perks
We'll be pulling our weight at your place with handy discounts, helpful options to spread out your payments. Get the lowdown on all latest perks here.
You can connect right here right now – it'll just take a few minutes.
Click below to get connected or phone 0800 80 9000
Tips and perks on generating your own electricity.
Side step unexpected spikes by spreading out your payments. Makes budgeting a whole heap easier.
Visit our Saving Energy page to learn more about how to keep your home snuggly 'n dry in winter, cooler in summer..and save money!


text:
Robert Cray Update
After nine months still one best purchases I've ever made. The RC is dollar for dollar one of the best Fender values. The neck radius and profile is nothing short of perfection. As I mentioned in my previous rating; prior to purchasing I had concerns about the neck shape/profile being too big and not being able to find one in a store to try out prior to ordering. I have what I would term average length fingers for a guitarist and IMHO this neck was made for my hands. Smooth, great tone, beautiful in the 3 color sunburst and I will likely order the other color as I finally got to see someone with it and beautiful as well. MIM??? Might as well be in USA as it is top quality for a ton less money


text:
The cost of repairing the damage caused by floods that killed eight people over the weekend is likely to be tens of millions of pounds, insurers warned today.
But that figure could rise even further as forecasters predicted more rain later this week, hampering the clean-up effort.
Saturated Britain faces a week on flood alert after downpours caused death and devastation.
Flooded streets close to York city centre as the River Ouse burst its banks flooding following torrential rain over the weekend.
Worcester's centre flooded as the River Severn burst its banks in the town after days of heavy rains.
Eight people have died in incidents linked to the horrendous weather since Friday - and more heavy rain is forecast.
There was anger as hundreds returned to their flood-damaged homes in the Northumberland town of Morpeth yesterday after emergency services carried out a mass evacuation.
Residents criticised a lack of council action in protecting their homes and helping to clear up the mess.
Flash floods in June last year had been described by Government ministers as a 'one in a 150-year event', but Environment Agency officials admitted the weekend's deluge in Northumberland was on a similar scale.
Floods have also hit parts of Yorkshire, Shropshire, Herefordshire and Worcestershire.
Surrounded: Fields next to a road into Worcester are swamped by floodwater
The picturesque town of Tewkesbury, Gloucestershire, revisited scenes from last years as its 12th Century Abbey became an island once again.
With fields becoming lakes, reservoirs full and river levels high, David Rooke, the agency's head of flood risk management, admitted there was 'no room to manoeuvre'.
'It all depends on the amount of rain we get over the coming week,' he said.
'Most parts of the country are saturated.' Even Met Office forecasters admitted the weather was difficult to predict accurately.
But after a second successive washout summer, there were few grounds for optimism.
Deja vu: Tewkesbury's was an island again 13 months after the last big flood
Seven severe flood warnings were in force, all in the North-East. There were also 81 flood warnings, predominantly for the North, Wales and the Midlands.
At the end of this week the South can expect a dry spell, but northern England faces two weeks of unsettled and potentially disastrous weather.
In Morpeth the clean-up bill is likely to run into millions after 500 residents, many of them elderly, were evacuated on Saturday as floodwater suddenly swamped the streets.
Good sport: A canoeist makes the most of the floods at Worcester Racecourse
Airlifted: An RAF helicopter rescues a stranded flood victim in Morpeth
'Several hundred' homes in four areas of the town were flooded and up to 1,000 properties were at risk.
And Association of British Insurers said initial estimates suggested damage claims around Britain would run into the 'low tens of millions'.
The crisis was caused by a combination of torrential rain leading to a massive amount of surface water and the River Wansbeck bursting its banks and breaching flood defences. Almost a month's rain fell in 24 hours.
As roads turned into rivers, muddy water swamped streets, cars and the ground floors of homes, ruining possessions and causing heartbreaking damage. At its worst the High Street was under two feet of water. More than 200 people spent the night in emergency shelters.
Resident Jessica Leonard, 48, said: 'Floods aren't a new thing so why weren't there any plans in place? The council has done absolutely nothing for us. We even had to buy our own sandbags.
'The people you see washing the dirt from the streets are residents and not the council.'
Peter Jackson, leader of Castle Morpeth Borough Council, said: 'Because there is more rain to come and a severe warning for Tuesday, we are planning for the worst but hoping for the best.'
Further south there are concerns about the Ouse near York and the Severn. The Met Office predicted heavy rain across the country tomorrow and Thursday.
The victims of the weather included geologist Alex Wright, 27, who was killed when a trench he was working in collapsed at a building site in Stroud, Gloucestershire.
A taxi driver also died in the country yesterday morning after his car skidded off a main road alongside the River Severn.
In Powys, mid-Wales, a 17-year-old girl from Thamesmead in South London died when the 4x4 she was in plunged into floodwater.
In Plymouth, Barry Rowe, 28, and his girlfriend Rebecca Hoynes, 30, died when their car hit a tree in heavy rain.
A 42-year- old Sheffield man was killed when his motorbike hit a branch on the A66, and a middle-aged woman died in the sea at Barton on Sea in Hampshire.
A man also died swimming in heavy seas at Perranporth, Cornwall on Saturday afternoon. Rescuers braved 4ft waves and force 6-7 winds.
And despite last year's flooding nightmare the hard-hit town of Tewkesbury was once again tuned into an island by days of heavy rainfall.
Breached: The burst banks of the River Severn in Worcester
And it could get worse depending on the intensity of downpours this week.
The disaster of 2007, in which three people died and 140,000 homes without tap water for two weeks, did not lead to any plans for major flood defence schemes.
The Environment Agency said flood warnings were in force for the area, but they had received 'no reports of river-related flooding' so far.
Heavy rain is expected tomorrow and more on Thursday. The chances of another flood are 'significant.'
Mayor Barbara Cromwell said: 'People are very worried and nervous about what is going to happen this time.
'Sandbags are available to householders concerned about water levels and the council is on standby.'
Councillor Brian Calway added: 'We don't have substantial flood defences to protect the town and I think that's because the authorities don't believe it is practical. However, there are areas where we have been pressing for work to be done.'
Submerged: An RAF aerial photo of Morpeth following torrential rain and rising floodwaters
- More about:
- Gloucestershire
- Northumberland
- Worcester
- Worcestershire


text:
06_hawk_eye 06_hawk_eye is offline
WRXtuners Member
Last Activity: 05-20-2014 07:08 PM
About Me
- About 06_hawk_eye
- City
- lancaster
- State/Country
- Pennsylvania
- WRX Model
- WRX Year
- 06
- Mods-speed
- now....helix catted downpipe, cobb stage 2 flash
soon... perring top mount intercooler,cobb intake plus box, DeatschWerks Fuel Injectors 650cc,welbro 255 fuel pump, ihi vf43 turbo.GrimmSpeed Boost Solenoid,AMR Performance Cast Aluminum Turbo Inlet
protuned at psi proformance
- Mods - drivetrain
- looking for upgraded 5 speed gears
- Mods -suspension
- GF210 lowering springs
- 0.000
- 0.000
- Nitrous? (on Dyno)
- With Nitrous
- Favorite WRX shop/Vendor
- jsc speed
- Your Shop Name
- Lancaster toyota mazda
- Occupation
- Technician at lancaster toyota
Total Posts
- Total Posts: 699
- Posts Per Day: 0.42
- Last Post: Dyno Chart - How to Interpret 03-29-2014 11:45 PM
- Find all posts by 06_hawk_eye
- Find all threads started by 06_hawk_eye
General Information
- Last Activity: 05-20-2014 07:08 PM
- Join Date: 11-25-2012
Showing Friends 1 to 1 of 1
- boo-key
- Moderator
- boo-key is offline
|01:03 AM - sugeina quoted 06_hawk_eye in post [post=444345]Dyno Chart - How to Interpret[/post]
Looks like it should be the a/f ...
|08:48 PM - 06_hawk_eye quoted Jsnacker in post [post=442361]My 04 wrx chances to win race...?[/post]
So a kid is talking trash on ...
|07:37 AM - quoted 06_hawk_eye in post [post=441457]2006 WRX not boosting past/stuttering at 10 psi[/post]
I was having a similar problem a...
|07:42 PM - 06_hawk_eye quoted sleepr in post [post=441241]Two Word Game[/post]
fire crotch Crotch rocket ...
|07:28 PM - 06_hawk_eye quoted Chris-pee in post [post=441217]2006 WRX not boosting past/stuttering at 10 psi[/post]
I took a quick video, thanks f...
|07:04 PM - Chris-pee quoted 06_hawk_eye in post [post=441209]2006 WRX not boosting past/stuttering at 10 psi[/post]
I was having a similar problem a...
|03:34 PM - 06_hawk_eye quoted Brockton in post [post=439377]TD04 Rubuild kit needed.[/post]
I know, and there are rebuild...
|11:24 AM - 06_hawk_eye quoted Brockton in post [post=439265]TD04 Rubuild kit needed.[/post]
No one rebuilds these. Once ...
|07:01 PM - 06_hawk_eye quoted Scotte549 in post [post=437418]Hate the car above you[/post]
im gonna get roasted but i don...
|11:07 AM - 06_hawk_eye quoted subie02x in post [post=436617]Turbo shutting off high rpms?[/post]
I know its a "Stand Alone Sys...
|10:38 AM - 06_hawk_eye quoted subie02x in post [post=436601]Turbo shutting off high rpms?[/post]
It has up pipe, down pipe + i...
|06:53 PM - 06_hawk_eye quoted BLAZE2099 in post [post=435873]Turbo smoke...[/post]
Hey hawkeye, don't you know so...
|06:36 PM - 06_hawk_eye quoted Epictofer in post [post=435841]Turbo smoke...[/post]
All i asked for were suggestio...
|08:15 PM - 06_hawk_eye quoted turmic in post [post=435625]2014 WRX AP V3 warranty void[/post]
It doesn't really magically...
|10:54 AM - 06_hawk_eye quoted NeverSummer in post [post=435474]Turbo smoke...[/post]
[QUOTE=NeverSummer;435450]I wasn't tryi...
|10:54 AM - 06_hawk_eye quoted in post [post=435474]Turbo smoke...[/post]
|04:53 AM - sleepr quoted 06_hawk_eye in post [post=435362]Emissions Test Suggestions?[/post]
Put car back to stock and pass e...
|06:50 PM - 06_hawk_eye quoted jthwjde in post [post=435274]Where do I go now?[/post]
If i don't decide to go with...
|06:48 PM - jthwjde quoted 06_hawk_eye in post [post=435266]Where do I go now?[/post]
For the compression and leak dow...
|06:25 PM - 06_hawk_eye quoted jthwjde in post [post=435258]Where do I go now?[/post]
Where would I take it for th...
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text: Thanks for the awesome tutorial! I made a few adjustments for the type of dragon i wanted and mine is more free standing instead of a shoulder attachment because of the size.I used folded duct tape for the spine spikes and modpodge and hot glue for the wings. Turned out great and couldn't have done it without your guidance.View Instructable »


text:
VideoHive The City Is Yours 123133
After Effects Project Files \ Video Displays \ 3D Object
The City Is Yours 123133 by StareTactics @ VideoHive
After Effects Project Files \ Video Displays \ 3D Object
After Effects Version: CS4 File Size: 400mb Requires Plugins: No Resolution: 1920x1080
This is a 3D city created to showcase your banners and billboards in Full HD. Pre Renders ensure a quick render time on your end. Most of the billboard sequences are rendered as individual videos, so you can easily shorten, lengthen or rearrange the project.
The video has 10 billboards, where you can quickly and easily put in your own images (or video) and text.
No plug-ins needed.
Ive included a video help file on how to use this project.
Free font available at http://www.dafont.com/bebas-neue.font
Images and videos used on the billboards are not included. Music in the preview is not included.
Please let me know if you have any questions.
Download Link


text:
In addressing the annual congress of ruling party United Russia, Medvedev said that he was prepared to take on 'practical work' in the government after the March presidential polls. Which could be a hint to be prime minister in a new Putin presidency.
"I think it would be correct for the congress to support the candidacy of the party chairman, Vladimir Putin, to the post of president of the country," Medvedev added.
Since 2008, Medvedev has been extensively working to modernize the country and assured his "readiness to assume practical work in the government" in the future. "If the party wins the elections and I am almost certain of it, if we continue working just as well then I am ready to continue doing real work to modernize the country", he added.
The presidential elections are scheduled to be held in March 2011 and the the candidate of United Russia, which dominates the country's politics, is almost certain to win and control of the Kremlin.
Putin said he and Medvedev had 'long ago' agreed on their future roles in Russia, despite months of suspense over who would stand in the presidential elections.
"I would like to say directly that the agreement about what should be done, what we should be doing -- that we reached a long time ago, several years ago," said Putin.
"I propose that the list of United Russia for the State Duma elections on December 4 be headed by the head of state, Dmitry Medvedev," Putin said.
Earlier, in 2008 Putin left the Kremlin after serving a maximum two consecutive terms as President but carried on as Russia's de-facto number one as prime minister while his hand-picked successor Medvedev served as a sometimes overshadowed president.


text:
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We've raised £0 to You may have seen the silly haircut I'm done to raise money for multiple cancer charities
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Crowdfunding is the new way to raise money for a personal cause on JustGiving.
A number of work colleagues and family members always need support so let's try to raise a bit of money towards multiple charities cheers all.
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text:
Our Projects
The CT research group at the Wels Campus is working on different research projects in cooperation with various scientific research organisations and industrial partners.
Running research projects
|Project Name
|Multimodal and in-situ characterization of inhomogenous materials
|ADAM - Advanced Multimodal Data Analysis and Visualization of Composites based on Grating Interferometer Micro-CT Data - www.3dct.at/adam
|Quantitative X-ray tomography of advanced polymer composites
|K-Project ZPT+
|K-Project for Non-destructive Testing and Tomography Plus - www.nondestructive.at
|Interactive gonarthrosis data base for the three-dimensional microstructure, geometry, and biomechanics of the knee joint
|Competence Center for High-Resolution 3D X-ray Imaging
|Metrology for Additively Manufactured Medical Implants
|International Network for the Training of Early stage Researchers on Advanced Quality control by Computed Tomography - www.interaqct.eu
Multimodal and in-situ characterization of inhomogenous materials
MiCi: 01.01.2016 - 31.12.2021
Multimodal and non-destructive testing (NDT) methods are essential in order to characterize materials during their processing, e.g. during thermo-mechanical treatments, and to enable in-situ monitoring of the production process. In this project different NDT methods will be realized in a multimodal test rig. This enables the comparability of different NDT methods. In addition, a new high-resolution X-ray computed tomography system with in-situ stages will be acquired and used for the characterization and validation of NDT methods. Beneath experimental validations, resolution limits of the different NDT methods will be compared to theoretical limits. The experimental and theoretical approach will help to identify the best NDT methods for characterizing certain processes and to locate critical defects within the inspected materials.
Com3d-XCT: Competence Center for High-Resolution 3D X-ray Imaging
Funding period: 1.10.16 - 30.09.17
Non-destructive testing (NDT) of components by means of microcomputed tomography (XCT) is an important task in many fields, e.g. in the automotive and aerospace sector. However, the demands towards NDT methods are continuously increasing due to the development of advanced, complex material systems. Accordingly, new multi-disciplinary NDT approaches have to be developed to approach the challenges in the in-depth 3D characterization of advanced materials.
MetAMMI: Metrology for Additively Manufactured Medical Implants
Funding period: 1.06.16 - 30.05.19
The medical sector is set to benefit immensely from the rapidly expanding additive manufacturing (or 3D printing) industry, which has the capability to print a range of medical devices, such as prosthetics, dental implants and hearing aids, tailored to a specific patient.
While medical devices are subject to strict safety requirements, additive manufacturing technology has advanced at a much faster pace than the available standards and quality controls. The high roughness, complex geometries, and internal structures of additively manufactured medical devices make acquiring accurate data for quality control challenging.
Quantitative X-ray tomography of advanced polymer composites
Advanced composite materials (ACMs) typically contain two or more constituents, such as matrix, fibers, inclusions and pores, with different physical and chemical characteristics. When combined, they produce a material with unique properties in terms of weight, strength, stiffness, or corrosion resistance.
To inspect and study their 3D internal structure in a non-destructive way, the ACMs are imaged using X-ray computed tomography, in which a 3D dataset is reconstructed from the X-ray radiographs. The 3D dataset is subsequently further processed and analyzed in multiple sequential steps. This conventional workflow, however, suffers from inaccurate modeling and error propagation, which severely limits the accuracy with which ACM parameters of interest can be estimated.
ADAM - Advanced Multimodal Data Analysis and Visualization of Composites based on Grating Interferometer Micro-CT Data
ADAM project duration: 01.03.2016 - 28.02.2019
Within recent years, the need for new, cost-effective, function-oriented, highly integrated, and light-weight components has strongly grown in many high-tech industries such as aerospace, automotive, marine, and construction. The drivers behind this trend are mainly found in the rising application demands regarding efficiency, safety, environment, and comfort. Among desired functional and -mechanical properties, the requirements on new materials and components include high strength, elasticity, durability, energy efficiency, and light weight. Unlike conventional materials such as aluminum, steel, or alloys, fiber-reinforced polymers (FRPs) – composites made of a polymer matrix reinforced with carbon, glass, or other type of fibers – fulfill these requirements to a high extent. To design new materials and components, detailed investigations and characterizations of FRP materials are vital. In industrial settings, FRP components and materials are nondestructively tested, e.g., by visual inspection, tapping, or ultrasonic inspection. However, conventional methods are increasingly facing their limits regarding accuracy, level-of-detail, and inspection time. To overcome these limitations, industrial 3D X-ray computed tomography (XCT) has received much attention in quality control due to its high spatial resolution and ability to precisely capture external and internal structures in one scan. Compared to other non-destructive testing methods for FRPs, XCT is yet the only method capable of delivering full 3D information for detailed inspection and quality control.
K-Project for Non-destructive Testing and Tomography
K-Project ZPT: September 2009 - August 2014
The need for NDT methods is driven by the development/innovation of new products, materials and technologies and by the demand for enhanced quality control and cost reduction in industry. Many countries have already established specialized research centre for NDT. With the K-Project an applications-orientated NDT research centre will be created in Austria concentrating and strengthening research on modern NDT methods and application in the country. The combined expertise on NDT-methods and applications-oriented materials science will build a unique knowledge base with regard to non-destructive evaluation. The main focus will be on the following methods...
spaceXCT: X-ray Techniques for NDT and Damage Characterization of Space Materials and Components
Funding period: 1.06.16 - 30.05.17
One of the main challenges to accelerate the acceptance and use of advanced materials (e.g. polymer matrix composites, additively manufactured parts & electrical, electronic and electro-mechanical components) in the European Space Agency (ESA) is to establish a broadly accepted materials and process quality system, including adequate non-destructive testing (NDT) procedures. However, to profoundly exploit the advantages of advanced manufacturing for space applications, and to ensure highly reliable parts, new approaches to both manufacturing and non-destructive testing (NDT) are needed. NDT procedures must be able to track unique features such as small scale and deeply enclosed porosity, complex part geometry, and subtle internal features.
In the course of spaceXCT we exploit innovations of advanced X-ray imaging technologies, e.g. high resolution X-ray computed tomography (XCT) and grating interferometer X-ray computed tomography (TLGI-XCT), addressing various problems concerning materials science and material processing in space applications. We introduce advanced X-ray technology overcoming disadvantages of standard methods ranging from the inspection of thermally induced crack propagation in polymer composites, void growth during load testing of additively manufactured titanium parts, and crack growth in solder joints of ball grid arrays on multilayer printed circuit boards.
ArthroKnee: Interactive gonarthrosis data base for the three-dimensional microstructure, geometry, and biomechanics of the knee joint
Funding period: 1.10.15 - 30.09.17
Due to the increasing life expectancy the incidence of osteoarthritis (OA), the degeneration of articular cartilage and bone in the knee joint, is increasing worldwide. If all alternative treatment options are unsuccessful knee replacement surgery is inevitable. Concerning the annual number of knee replacement surgeries, Austria occupies an international leading position. Although the success rate of knee arthroplasties is high, complications like the loosening of the implant necessitate subsequent treatments. Moreover, the morphology and microstructure of the knee joint varies considerably between patients, therefore the anatomical expertise of orthopedic surgeons is essential. However, the clinical diagnosis is mainly based on radiological findings that neglect the three-dimensional architecture and microstructure of the knee joint.
Compact X-ray computed tomography system for non destructive characterization of nano materials
NanoXCT: May 2012 – April 2015
Within the past decades, advances in miniaturization from micro to nano-scale have had dramatic impacts on our lives. Consumer electronics, which once occupied large volumes, now fit in the palm of a hand. But nanotechnology does not only improve electronics. Also material sciences, chemical engineering or biology are strongly profiting from nanotechnology. The tremendous achievements in all of these areas would not have been possible without corresponding material analytics techniques. Material analytics for nano-scale characterization currently cover destructive methods, surface inspection methods or 2D methods. To date it is not possible to get a comprehensive representation of a specimen including internal and external 3D-structure analysis as well as a chemical analysis without destroying the sample. In this respect nano-scale material analytics is currently on the edge of a new era, which is targeted in NanoXCT. The project addresses the limitations of conventional techniques using 3D X-ray computed tomography, which allows for a non-destructive and fully three-dimensional characterization of specimens.
International Network for the Training of Early stage Researchers on Advanced Quality control by Computed Tomography
InterAQCT: October 2013 – September 2017
The non-destructive quality control of a wide variety of high-added value products, produced by innovative manufacturing techniques, remains a challenge. Examples include additive manufacturing parts, micro parts, and fibre reinforced composite parts. Common to these workpieces is the dependency of their performance on internal and inaccessible elements. Nevertheless, customers in multiple sectors are requesting certified quality and reliability.


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PRESS DIGEST- Canada- June 11
June 11 (Reuters) - The following are the top stories from selected Canadian newspapers. Reuters has not verified these stories and does not vouch for their accuracy.
** Canadian Pacific Railway Ltd says it bears no responsibility for the Lac-Megantic oil train explosion, and will not pay into a fund that compensates families of the victims of the 2013 disaster. (bit.ly/1MKWVef)
** Many companies have shown bare "technical compliance" with new gender-diversity reporting rules introduced this year and it is "simply not good enough," Ontario Securities Commission chair Howard Wetston says. (bit.ly/1S79kw0)


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Showing Results 1 to 1 of 1 (0.000 secs)
Last Indexed: 02/18/17 08:12:14
Last Post: 06/23/17 05:54:34
|Topic Title
Serious (i.e: Not funny real world scenario type) Zombie Flyers, Phamplets, Stickers, Graffiti and Similar. (topic)
I tried to find the above on my own, but most of what I found was just humorous stuff. I'm looking for serious flyers and what-not, like what the military, the police, the fire departments, the hospitals, emergancy services, and the...
|All Flesh Must Be Eaten RPG


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Suntanning Nikol fucked on boat for cash
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Best in Show
"Best in Show" unisex pocket print t-shirt designed by French artist Walter Glassof exclusively for Growlees.
Available in white or grey marle.
Made from 100% combed organic cotton. Member of Fair Wear foundation.
Loose style, fits large to size. Model is 1.80m and wears a size Medium.
T-shirts are custom made so please allow 3-5 days for dispatch.


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Gold trades back to $1,160/oz after testing $1,155/oz low, focus on Bernanke's comments
FXstreet.com (Barcelona) - The gold's decline from $1,168/oz, today's high, has found support at $1,154/oz during the European session with the XAU/USD rising back to trade above $1,160/oz. Currently the pair is trading around $1,161.50/oz, 0.20% above today's opening price action at $1,158/oz.
Fed Chairman Ben Bernanke has commented yesterday that US will have an extended period of low interest rates with the inflation subdue for some time. Words could reduce the appetite of gold as hedge.
James Moore, analyst at The Bullion Desk, comments: After a relatively flat Asian session the stronger dollar put gold back under pressure, leading the yellow metal to a two-week low of $1135.20 before consolidating around $1140-45. The greenbacks reaction to Bernanke's comments led gold to close at $1161 and the metal has seen a mixed start so far this morning as traders continue to track the dollar. The expectations of record low US interest rates will likely limit substantial weakness in gold however the metal still remains at risk to pressure as further profit taking is expected in the run-up to year-end.
The Aussie's decline against the Dollar from intra-day high at 0.9165 has found support at 0.9080 in the early European session with the AUD/USD bouncing to trade above 0.9100 level, close to 0.9120.


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Each month, Rated People connects over 50,000 homeowners with quality tradesmen - simply enter your job details in the form above to get started.
We'll match your job to the relevant tradesmen in your area - those interested will pay to see your contact details and call you to quote.
As each tradesman expresses interest in quoting on your job, we'll send you their profile and ratings to help you choose the right one for you.
After the work is complete, return to the site and rate your tradesman based on their quality of work, reliability and value for money.
Added 21/03/2017
Bed side table handles to be attached Metal slats for bed to be replaced Tv brackets to be...
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to clean out gutters around large house
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Added 04/09/2016
Fixing Door bell which has fallen off, needs re-hanging, repairing damaged walls where we have...
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Re tile the floor of a small toilet- 4'by3' Box in the U bend in same toilet Paint new woodwork...
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*PRIORITY LEAD* Changed information:budget, contact details I need a fence erecting at the...
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Very useful for short notice appointment
Absolutely excellent! I received a quote within 30 minutes of posting the job, they were able to attend very quickly and got the job done with the utmost care and attention. Very happy customer and thoroughly recommend them.
John was punctual, professional and skilled. He did a great job, am very satisfied.Will keep his card in a safe place.
Another fantastic job - arrived early and stayed late - worked all day without complaint. Will definitely use them again! Thank you
Really quick service. Quality work! No complaints whatsoever!
Managing your job is easier with the Rated People Homes App, download it today.


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Added on 20-Jan-2005
Wondering who will play bass on the upcoming Queen tour, given that there will be no John.The suggestion here is to go with Gail Ann Dorsey, David Bowie's bass player for teh last few albums / tours. Why? Well apart from being a fantastic bass player and singer, these are some quotes from here:Gail Ann Dorsey: Early on, on the Outside tour, David asked would I consider singing Under Pressure like the Annie Lennox duet he performed at Freddie Mercury's Memorial Concert.Gail Ann Dorsey: Queen is my favorite band of all time and I remember being so overwhelmed at David's suggestion that I cried.Gail Ann Dorsey: To sing a part originally sung by Freddie Mercury so far has been the greatest honor of my life.
Submitted by:
Richard Orchard


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Whittier Union High School District
Documentation Needed for Enrollment
In order to enroll, the following documentation is required:
Transcripts: A copy of the student's most recent transcript(s).
For summer 9th grade enrollment, please provide the last report card from the forwarding middle school.
Withdrawal grades from most recent school, if student is enrolling during the school year.
Immunization records: Students must have all required immunizations.
Residency verification documents: Provide current copies of two of the following documents
(dated within the past 60 days):
sUtility bill sEscrow papers sRental agreement sVoter registration sDriver's license/ State ID
sPay stub sProperty tax sCorrespondence with government agency
We do not accept disconnect notices or mobile phone bills.
If applicable, please provide the following documents:
Special Education documents: Special Education staff members will review documents
prior to enrollment to ensure appropriate placement of the student.
IEP: Provide a copy of the most recent IEP.
Psychological report: Provide a copy of the most recent psychological report.
Section 504 Plan: Please provide a current copy of your child's Section 504 Plan.
Language Assessment (CELDT)
Expulsion Documents (if currently expelled from a public school)
Medical Orders: Please provide any current medical orders or other district medical forms upon enrollment and before the start of each school year or when there are changes.
Birth Certificate: (If student has been enrolled in another California public school, this is not required. Please
provide only for students enrolling from a private school, out of state, or out of the country.)
*Please inform the Guidance Office staff if the registering student is in foster care.
**Any students entering from another country must have all documents translated into English.


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Hotels in Hadley, Massachusetts
Search & Compare Hadley Hotels
Get Secret Prices on select hotels
These prices aren't available to everyone.
Best hotels in Hadley
Hadley overviewHadley is a budget-friendly place distinct for its sports and known for its college atmosphere and shops. You're sure to appreciate the ample coffee and dining options. Take in some local culture at popular places like Volleyball Hall of Fame and Naismith Memorial Basketball Hall of Fame. Make some time to enjoy the local sights such as Springfield Armory. If you're looking for a family- and business-friendly getaway, Hadley is for you.
Where to stay in HadleyFeaturing accommodation choices that can meet everyone's needs, Hadley is the place to go. There are 63 hotels in the Hadley area, some with discounts of up to 30%.
- • 28 2-star hotels with an average price of $56 per night
- • 28 3-star hotels with an average price of $95 per night
- • 6 4-star hotels with an average price of $139 per night
Here are the top hotels based on 8374 user reviews of Hadley hotels:
- • Courtyard by Marriott Hadley Amherst (Hadley)
- • Hampton Inn Hadley/Amherst area (Hadley)
- • Holiday Inn Express Hotel & Suites Amherst-Hadley, MA (Hadley)
- • Comfort Inn Hadley - Amherst (Hadley)
- • Econo Lodge (Hadley)
How to get to HadleyFly in to Hartford, CT (BDL-Bradley Intl.), 28.9 mi (46.5 km) from downtown Hadley. Boston, MA (BOS-Logan Intl.) is the next closest major airport, 80.2 mi (129.1 km) away.
What to see around HadleyFun outdoor activities are on hand along with these attractions:
- • Mullins Center
- • Chesterfield Gorge
- • Smith College
- • Hampshire College
- • Amherst College
- • University of Massachusetts-Amherst
- • Mount Holyoke College
- • Springfield Armory
- • Volleyball Hall of Fame
- • Naismith Memorial Basketball Hall of Fame
When to visit HadleyIf you're still deciding when to visit, here are the seasonal norms to help you plan:
Seasonal temperature averages
- • January-March: 52°F day, 18°F night
- • April-June: 81°F day, 35°F night
- • July-September: 83°F day, 48°F night
- • October-December: 67°F day, 21°F night
- • January-March: 9.5 inches
- • April-June: 12.0 inches
- • July-September: 11.6 inches
- • October-December: 11.6 inches


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Для получения актуальных цен по гостинице Ramada Farnham, пожалуйста, укажите интересующие вас даты и выполните поиск.
The hotel is located just off the A31 overlooking a designated area of natural beauty in England's rolling Surrey countryside. Guildford town centre is 13 Km from the hotel. Attractions in the region include Thorpe Park (38 Km) and Chessington World of Adventures (37 Km). The hotel is also within easy reach of the M3 motorway.
This 3-star tourist-class hotel overlooks rolling Surrey countryside. The hotel provides well equipped accommodation and boasts a health club featuring an indoor swimming pool. A good base for exploring the region.
Номеров: 96
|The property is a red brick building.
|Описание номеров
|Rooms are comfortable and well equipped. They feature a flat screen television with radio and broadband internet access (charged).
|Бары и рестораны
|The Arts Restaurants has views over the gardens and offers traditional and internationally inspired cuisine. The restaurant is open for breakfast, dinner and lunch from Monday to Friday and on Sundays. In addition the Club Bar serves light meals and is the perfect place to relax in after a busy day.
|Спорт и отдых
|The health club features an indoor swimming pool with a small children's pool, a gym and sauna and steam room. Beauty treatments are also available at the hotel.


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Complete with four images from the LIK Squared portfolio, each Designer Pack is available in two sizes designed to complement any interior space.
LIK Squared Mosaic Prints come to life on Fujiflex Crystal Archive Media, reproduced using a true photographic process revealing vivid colors, sharp contours and unmatched contrast. Each image is then protected between two layers of Crystal Clear© acrylic and finished with a White Komatex PVC Backer. All LIK Squared products are unsigned, open editions.
Hanging System Ready to hang out of the box, our Small Designer Packs feature a centered keyhole while our Medium Packs feature a dual keyhole hanging system for quick and easy installation.
LIK Squared products are custom-made and require 4-7 business days for production. Please take this into consideration when ordering and selecting your shipping methods.


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Anyone who operates a Mercedes-Benz knows that when it comes to repairing their car, truck, or SUV only the most superior replacement parts will do. The vehicle in your driveway is head and shoulders above the rest compared to all the other cars, trucks, and SUVs on the road today. You picked your R500 because its a reputation for strength and German engineering appealed to your senses; so why would you be okay with anything but the best when it comes to the highest quality auto parts? Car aficionados appreciate the luxury built into each Mercedes-Benz, and know that only top quality repair R500 parts will suffice when maintenance needs to be done.
There are some parts so ubiquitous on cars today that it is hard to believe they were once only optional equipment on luxury vehicles. Your Mercedes-Benz R500 tire pressure monitoring system (TPMS) is one of these devices. When you notice a small exclamation mark inside a flat tire illuminated on your dash board, that is your tire pressure monitoring system sensor letting you know that pressure in one or more tires is low. That light should turn off after filling your tires with air; if not, then you will have to replace your Mercedes-Benz R500 TPMS sensors.
Bring your R500 back to life with the highest quality new or rebuilt parts from the experts at Car Parts Discount. Make all your future car parts purchases at carpartsdiscount.com and save time and money on all your upcoming repairs. At Car Parts Discount, we have live customer service members here with enough expertise to help you buy the correct Mercedes-Benz R500 part for your needs. When it comes to Mercedes-Benz R500 Tire Pressure Monitor Sensor TPMS parts, you can find them for 2007, 2006 models by clicking the appropriate year below.


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For more information on how you can become a member of the Potter Park Zoo please click here.
Magellanic penguins are named after Ferdinand Magellan who first discovered them in 1519.
"PPZ Rocks because it is a place you can be a kid again."
- Rae F, DeWitt
Get events and information delivered to your inbox. No spam... promise.
Potter Park Zoo
1301 S. Pennsylvania Ave.
Lansing, MI 48912
Contact Us |


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Each month, Rated People connects over 50,000 homeowners with quality tradesmen - simply enter your job details in the form above to get started.
We'll match your job to the relevant tradesmen in your area - those interested will pay to see your contact details and call you to quote.
As each tradesman expresses interest in quoting on your job, we'll send you their profile and ratings to help you choose the right one for you.
After the work is complete, return to the site and rate your tradesman based on their quality of work, reliability and value for money.
Added 17/08/2015
Repair toilet Toilet cistern leaking The item to be repaired is easily accessible
Added 03/08/2015
Leak under bath needs addressing
Added 12/06/2014
shower control broken and cannot be turned off. As a result had to turn water off to whole...
Added 10/04/2013
We need a sink removing from a bedroom so there is no sign that it used to be in there. This...
Punctual, Professional and good value, will use HEating again and recommend rated people for finding quality tradespeople.
Very impressed with work - finally I got someone who was able to diagnose & fix long-standing problem with overflow. Would definitely recommend!!
Right from getting a quote from Matt he was the only choice. The detail he gave when pricing up the job was first rate. He answered all questions I had and offered great advice throughout the quote and the job itself. Weather hampered the job but he still turned up and patiently waited in the van until the rain cleared. Great communication when he was unable to turn up due to persistant rain and gales blowing. I advise all users to use Matt. The cheapest quote and excellent workmanship. Thanks Matt .
Managing your job is easier with the Rated People Homes App, download it today.


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Other parents are taking the opportunity to have a holiday away from their children, where before they would not have dreamed of leaving them behind. This year, thousands of British youngsters are opting out of the family holiday and choosing instead to spend a week or more abseiling and quad-biking in the British countryside. Sending the kids to American- style summer camp is in fashion.
Camp Beaumont, a family firm which has run camp holidays for six to 18-year-olds for the past 17 years, says that the number at its summer camps has nearly trebled since 1987, to 16,000 this year, while PGL, the biggest and oldest operator, reports that it will be host to 18,000 children at its 30 activity centres during the summer, an increase of 50 per cent on its 1992 figures.
Superchoice (owned by Scottish & Newcastle, which also runs Centreparcs and Pontins) started in 1995 with a single residential centre on the Isle of Wight, and recently opened its second centre at Osmington Bay in Dorset. The company has invested pounds 1.75m in customising its camps for children, which are fully booked with 2,000 this year. Some parents are trying to reserve places more than a year in advance.
The "character-building" aspects of camp have created a fashion for them: in June, Harpers & Queen featured a long article about them, and the camp directors report a fair number of parents dropping their children off from Mercedes and BMWs.
Summer camp doesn't come cheap. Although day camps in London cost the same as a registered childminder, the current fashion is for residential camps lasting a week or more, which cost about pounds 280 per child per week. Sending two children for a fortnight costs the same as if the whole family were to go to Spain.
Both the parents and children think it's worth it. At Superchoice's Osmington Bay Centre, Dana and Kylie, both aged nine, are back for their second year at camp. They saved up out of their pocket money to help pay the cost of their two-week holiday. "Mum's on her honeymoon at the moment, and Kylie's Mum is in Rhodes," said Dana. "We arranged camp first though. We want to come for three weeks next year!"
For parents working full-time and with short holidays, summer camp is a solution to the problem of keeping the children busy during the long summer break. They come home having tried out new activities and made new friends, including some from abroad.
Julien, 16, from Orleans in France, said his favourite activity was power- boating. He came to Osmington Bay with his penfriend from England, and ended up staying an extra week.
Safety has always been a big concern for parents, particularly since the 1993 Lyme Regis disaster in which four teenagers drowned while canoeing. Now companies take extra care to train instructors and carers and check their qualifications, and invite parents to examine camp safety precautions for themselves. A new camp-accreditation body has started inspections to ensure that companies are following safety guidelines.
A lot of new business is coming through the children themselves. Lee, nine, is at Osmington Bay Centre for the second year running, but this time his friend Daniel, also nine, has come with him. When school resumes they will tell their friends what they did during the summer, and their friends may well ask their parents if they can all go together next year. Parents who know someone whose children have been to camp before are less wary, and often let a younger child go too, or the same children go back and stay an extra week.
In the US the children's summer camp has long been a flourishing institution, and in 1963 the American comedian Allan Sherman had an enormous hit on both sides of the Atlantic with his letter home from a less-than-happy young inmate. It went:
Hello, muddah.
Hello, faddah.
Here I am at
Camp Granada.
Camp is very
And they say we'll have some fun if it stops raining...
Then, the record was a chance for the British to laugh at an American pastime they knew little about. If it's raining this summer in the British equivalent of Camp Granada, an increasing number will know about it for themselves.
- More about:
- Canoeing & Kayaking
- Granada
- Isle Of Wight
- Mercedes Benz


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Get in the Spirit — 5 Festive Instagrams for Holiday Inspiration
Krrb is now part of the Apartment Therapy family! Check out the Marketplace for an even wider selection of furnishings and home decor.
Visit the Apartment Therapy Marketplace »
For most of the year, Instagram is where we go to envy things other people have (Guilty as charged!). The magical thing about the holiday season is that once you've finished your Thanksgiving turkey, the site becomes a mecca for wonderful wintertime ideas. Decor, tasty dishes, gifts and more…and we've saved you the hassle of digging through the seemingly endless #Christmas tag to find the best of the best. These well-curated feeds will cover your every want and need this season!
For Tablescape Goals: Rent Vintage Chicago
Nothing says "I've got this hosting thing down" like the perfect holiday dinner table. To really elevate your standards for an ideal setup, head to Rent Vintage Chicago's beautiful feed of vintage dinnerware. The rental company highlights a range of well-designed holiday tablescapes and settings, from rustic to elegant (but always with the perfect vintage touch). If you can't use their services directly, check out their stunning photography for a crash course in how to effortlessly mix vintage and modern styles!
For Sending Cheer: Miss Molly Vintage
As someone who's lived through 20-plus years of awkward family Christmas photos, I can say with confidence that sometimes you should just say it with words. That's why you should be turning to Miss Molly Vintage this year: their feed features gorgeous calligraphic holiday cards, each one well-designed while being warm and welcoming. Paired with cozy plaid stockings and ornaments, and I'm in a seriously festive mood. Shop small and stylishly!
For Festive Decor: Fynes Designs
Everyone has an individual decorating style, but who can say no to classic Christmas cheer? As soon as I saw the red-cheeked Santa on Virginia Fynes' feed, I was reminded of my grandma's 1960's holiday decor, but with a fresh twist. A modern advent calendar, festive gift wrapping and other seasonal tricks fill this bright feed, and many of them can be replicated on the Fynes Designs blog. You'll get inspired to get crafting, which is essentially just an excuse to blast holiday music and snack on some cookies. You're welcome.
For Handmade Inspiration: Un Peu Sauvage
As a dedicated wintertime knitter, chunky handmade scarves have been a holiday gift-giving staple of mine for the past few years. There's something really nice about receiving something handmade just for you, and Giulia of Un Peu Sauvage has been sharing some beautiful projects that anyone would want in their stocking (she might even be able to knit the stocking itself). Her knitwear is clean and minimal, and presented in a snuggly winter setting among steaming tea and pine needles. Check out Giulia's feed to feel like you're crafting away somewhere in a rustic cabin, no skills required.
For Enviable Eats: Aimee Ryan
And finally, we've arrived at arguably the best reason to go on Instagram during the holidays: the sweets! Vegan blogger Aimee Ryan has been sharing delicious looking photography of her Christmas baking, and my appetite doesn't appreciate it. From chocolate-orange pudding, to snowflake cookies and Danish butter trees, follow Aimee's account for some motivation to try something new this year. Sometimes your go-to sugar cutouts need a little healthy competition.
What Instagram accounts have you in a festive mood? Let us know in the comments!


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You can't even pretend that you don't say this iconic line over and over again, so be proud of it when you hang this officially licensed Star Wars "I Am Your Father" Darth Vader Poster! The dark side poster features a close up of Darth Vaders helmet with a Luke Skywalker reflection in the eyes and "No, I am your father" in white text along the bottom.
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great product, fast shipment
By lacey
from Kansas
About Me Budget Shopper
Comments about Spencer's I Am Your Father Darth Vader Star Wars Poster:
My baby boy Luke loves Darth Vader, this poster is awesome.
Bottom Line Yes, I would recommend this to a friend
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Digital cinematography is the latest revolution in the motion picture industry and, given its many advantages over the traditional use of film, it is here to stay. Major studios and independent filmmakers alike are embracing the newest technology and anyone considering a career in film production needs to become familiar with digital techniques.
» Read more: A Career in Digital Filmmaking: The Latest Development in the Film Industry


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the best
Verified Purchase
the best
We don't get cinnamon flavoured cereal in Australia so I always order 2-3 of these at a time. It's absolutely delicious, cinnamony and sweet. I love it!
Was this review helpful to you?
the best
Posted by 5719387240387465790 on Oct 24, 2016 | Verified Purchase
We don't get cinnamon flavoured cereal in Australia so I always order 2-3 of these at a time. It's absolutely delicious, cinnamony and sweet. I love it!
Really tasty
Posted by 4819029132872986585 on Jul 09, 2016 | Verified Purchase
Really tasty! It reminds me of the cereal late when I was little.
Posted by 4905512002673838258 on May 08, 2015 | Verified Purchase
Realllly tasty- even better than Cinmamon Toast Crunch!!
Posted by 4950137916699237694 on Mar 09, 2015 | Verified Purchase
These are my children's favorite cereal. Simple ingredients.
Better than Cinnamon Toast Crunch
Posted by 4762332782315513887 on Feb 22, 2015 | Verified Purchase
Cinnamon toast crunch is one of my favorite cereals so I was so happy to see a healthier, organic version. I actually like this better. It doesn't seem to get soggy as quickly as the general mills kind. Highly recommended!
Very good
Posted by 4821400751455065640 on Sep 11, 2014 | Verified Purchase
Taste just like cinnamon toast crunch but healthy & organic!
My fave!
Posted by 5112414961767277588 on Oct 25, 2013 | Verified Purchase
These have to be my favourite cereal of all time. I wanted to try them because I love cinammon and now I'm addicted. They are really crunchy and the cinammon flavour isn't overwhelming, just the perfect touch (for me, of course). I will buy again forever!
Great taste
Posted by Hjertemat on Sep 21, 2013 | Verified Purchase
My five year old LOVED it
Too sweet
Posted by 5437099393644365003 on May 03, 2016 | Verified Purchase
This is too sweet for me, first time I bought it and I didn't realise it would be so much sugar in it, won't buy this again.
Posted by 5332460355588563139 on Mar 12, 2014 | Verified Purchase
Not sure what happened as i was searching gluten free and brought this but its not gluten free? but still a good cereal
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