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Albert Einstein College of Medicine, Bronx, NY
INTRODUCTION: Pulmonary hypertension is a serious and potentially devastating disease of the pulmonary vasculature with diverse etiologies and pathogenesis. Schistosomiasis is a rare cause.
CASE PRESENTATION: A 50-year old male presented with a one year history of increasing abdominal girth and progressive shortness of breath. He reported a productive cough with occasional hemoptysis. His past history was significant for schistosomiasis in 1969 while in Yemen, for which he received treatment. He had moved to the United States approximately ten years prior to his presentation. His physical exam revealed room air oxygen saturation of 85%, jugular venous distension, loud P2, holosystolic murmur at apex and right parasternal heave. He had ascites and bilateral pitting edema of his extremities. Laboratory work revealed a normal complete blood count, basic metabolic panel and coagulation profile. Liver function showed only mild elevation in alkaline phosphatase. Hepatitis serologies and alpha fetoprotein were negative. Urine analysis was unremarkable and negative for red blood cells. Electrocardiograph revealed right ventricular hypertrophy and chest radiograph showed moderate cardiomegaly with prominent pulmonary arteries. Inspection bronchoscopy for evaluation of hemoptysis was unrevealing. His pulmonary function test, ventilation-perfusion scan and serologies for collagen vascular diseases were negative. A fast-ELISA test for schistosomiasis was non-reactive, stool studies and rectal biopsy were negative for parasites. Abdominal ultrasound showed periportal fibrosis. Echocardiogram showed a dilated right atrium and ventricle, severe tricuspid valve regurgitation with normal left ventricular systolic function. Cardiac catheterization confirmed severe pulmonary hypertension with mean pulmonary artery pressure of 66 mmHg, pulmonary vascular resistance 21 WU and cardiac index 2.1 L/min/m2 without pulmonary vascular reactivity to adenosine. Patient was started on home oxygen, aldactone, digoxin, lasix and oral pulmonary vasodilator therapy with endothelin receptor blocker,Bosentan.
DISCUSSIONS: Schistosomiasis is the third leading endemic parasitic disease in the world. Infesting more than 300 million individuals, these blood flukes live in the perivisceral veins. The eggs are shed in the urine and feces of infected individuals and the fresh water snail acts as an intermediate host. Pulmonary lesions are attributed to 3 species: S. haematobium, S. mansoni and S. japonicum. Acutely, transient chest radiographic abnormalities and nonspecific influenza-like symptoms can occur, including cough. Limited data suggests that cardiopulmonary schistosomiasis is seen most often in S. mansoni infections. In less than 5% of cases the eggs migrate through the pulmonary vessel wall and trigger a granulomatous response in the pulmonary vasculature. The end result of cumulative injuries to the pulmonary vasculature is the development of obliterative arteritis leading to fibrosis, pulmonary hypertension and subsequently cor-pulmonale. Diagnosis of cardiopulmonary schistosomiasis depends on the detection of viable schistosomal ova in stool , urine or rectal biopsy and serolgies along with evidence of characteristic hepatic fibrosis and pulmonary hypertension. Although treatment with praziquantel can effectively eradicate schistosomal infections with minimal toxicity, cardiopulmonary manifestations are not likely to be reversible given the chronic fibrotic tissue changes that are present. Our patient presented with right heart failure secondary to severe pulmonary arterial hypertension. With his history of residence in an endemic region, prior history of schistosomiasis and pathognomonic liver ultrasound findings with periportal fibrosis, chronic pulmonary schistosomiasis was diagnosed. In the absence of evidence for active infection specific treatment with praziquantel was not initiated. On treatment for heart failure and oral pulmonary vasodilator therapy, he demonstrated complete resolution of facial puffiness, ascites and pedal edema within a few days and a significant improvement in his exercise tolerance from a six minute walk distance of 335 meters to 550 meters over the next year.
CONCLUSION: To our knowledge, this is the first case report demonstrating the effectiveness of bosentan in treating a case of severe pulmonary hypertension secondary to schistosomiasis.
DISCLOSURE: Naricha Chirakalwasan, None.
Monday, October 23, 2006
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text:
Africa Oil: low oil price won't cause major delay to Kenya project
By George Obulutsa
NAIROBI Jan 21 (Reuters) - Falling world oil prices will not cause a major delay to plans to begin oil production in northwest Kenya, Africa Oil Corp's chief executive said on Thursday.
Keith Hill said the biggest hurdle was finalising construction plans for a crude oil pipeline.
Africa Oil and its partners aim to announce a final investment decision for production in early 2017.
"The current oil price has indeed put pressure on the project, but we do not believe this low price is sustainable. We do not see a major delay to the project as a result of the oil price, our biggest issue is getting the pipeline finalised," Hill said in an emailed response to questions from Reuters.
The pipeline will run from land-locked Uganda across northwest Kenya to a planned port in Lamu, on Kenya's Indian Ocean coastline.
Kenya and Uganda agreed to the route in August but they are still working out details, including financing. Uganda has an estimated 6.5 billion barrels of crude oil reserves.
Companies active in Uganda include France's Total, Britain's Tullow Oil and China's CNOOC .
Africa Oil and partner Tullow Oil first struck oil in Lokichar in northwest Kenya in 2012. The recoverable reserves are an estimated 600 million barrels of crude, which would feed into the pipeline from Uganda when it is built. Continued...

subset: commoncrawl


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Eric Pickles, the Tory chairman, infuriated the Liberal Democrats today by depicting the Conservative party as "the home of progressive liberal democracy in British politics".
In a speech timed to coincide with tomorrow's opening of the Liberal Democrat conference, Pickles said he was appealing to Lib Dem voters "to vote Conservative, not necessarily to be Conservative".
He accused Nick Clegg, the Lib Dem leader, of moving his party away from the "liberal centre ground".
And he announced the defection of a former Lib Dem parliamentary candidate, James Keeley from Skipton and Ripon, to the Conservative party. Pickles said Keeley was following in the footsteps of more than 50 councillors and nine former parliamentary candidates who had already defected from the Lib Dems to the Tories since David Cameron became Conservative leader.
Pickles's speech provoked an angry reaction from the Lib Dems, who claimed that he was scared of the threat from Clegg and that the Tory proposal to raise the inheritance tax threshold to £1m undermined Cameron's claim to be progressive.
"Liberal democracy has always formed an important part of the Conservative family. From the Factory Acts to [opposition to] 42 days' detention, the Conservative party will always be the home of progressive liberal democracy in British politics," Pickles said.
Aiming his speech at Lib Dem voters, Pickles added: "I know, if you are a Liberal Democrat voter, this might be uncharted territory for you.
"You might be really torn over what to do when you get into that polling booth. I understand that. But I am asking you to vote Conservative, not necessarily to be a Conservative.
"I'm asking for you to put your trust in David Cameron and our party to deliver on those things that we all want to see. Those things form a common ground that unites us – a progressive consensus, if you like – on which we can stand together and bring change."
Pickles claimed that the Tories had shown their liberal credentials when they voted with the Lib Dems for the Gurkhas to be allowed to settle in Britain and against 42-day pre-charge detention.
And he criticised Clegg for publishing a pamphlet yesterday saying that he wanted his party to replace Labour as the main progressive force in British politics.
"If you are a Liberal Democrat voter, you have a very clear choice," Pickles said.
"You could vote Liberal Democrat again – and vote for a party whose leader admitted yesterday that he is chasing the Labour party's votes and shifting further away from the liberal centre ground. That's one option.
"Or, you could do something radical – something progressive. You could vote for real change."
Danny Alexander, Clegg's chief of staff, said: "The Tory chairman's flawed view of history is matched only by his arrogance in assuming that he's got the general election in the bag and can now order people to vote for him.
"It is no wonder that Eric Pickles is getting worried by the Liberal Democrats, given the huge questions people have about the Conservatives. People know that the Tories only offer fake change, and that's why they are choosing the Liberal Democrats as the only party that will force through the big changes our country needs.
"Frankly, I think that if Tory HQ has got this much spare time on their hands, they should be trying to come up with some better policies than upping the price of salad in the House of Commons and giving tax cuts to millionaires."


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Movie fans love to discuss the best car-chase scenes, but it's not as often that we talk about car-race scenes. And yet there are a whole bunch of really great films wholly focused on professional and illegal car racing and others simply featuring memorable scenes of isolated automotive competition. Between the increased interest in the Fast and Furious franchise this year and now the release of Ron Howard's Rush, both street and sport racing is on our minds and we want to determine which one has the best race of all.
Each of the two varieties has seen its share of both dramas and comedies, and just because a race is funny doesn't mean it's not exciting, so it's difficult to pick a favorite. Try to weigh the action in Days of Thunder against the action in Talladega Nights: The Ballad of Ricky Bobby. And then compare either of those to the fantastical take on the sport in Pixar's Cars or to the real deal in the exhilerating documentary Senna, with all its genuine Formula One footage.
Not everyone is into the speedway and circuit-type auto racing, though, so let's also consider the illegal and nonprofessional movie races out there, too. There are those involving quick, straight-course, drag-type races as in the Fast and Furious series and significant parts of American Graffiti, Grease, Two-Lane Blacktop and more. Then there are those focused on cross-country rallies, such as the Cannonball Run movies, The Great Race and maybe the epic comedy It's a Mad, Mad, Mad, Mad World, which deals with a treasure hunt but one that has many people racing towards a finishing point if not line.
Other favorite films that entail terrific car-race scenes include The Love Bug, Les Mans, The Wraith, Snake and Mongoose, Grand Prix, Six Pack, Racing Dreams, Iron Man 2 and Speed Racer. There are tons more going back about as far as cars have existed. So, which one is the most thrilling for you?


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Very colorful items I found on ZALORA. I find it to be slightly KPop-inspired. What do you think of this edition of Picks and Finds?
I actually bought the pants a few days ago (and planning to buy all the other colors—please release pastels, Bench!) but that's for another entry. Don't forget to input Isparkleen120 upon checkout to get 5% discount on your colorful choices!


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This has been made possible by the fact that the foreign ministers of the two countries are cricket fans.
Australian foreign minister Alexander Downer who is on a a three-day visit to India said that the proposal for a touring exhibition had cropped up during his talks with his Indian counterpart Natwar Singh.
"Both the foreign minister (Natwar Singh) and I love cricket," said Downer.
"The exhibition will be very popular here," he said noting that cricket was very popular in both India and Australia. It would reinforce the bonds between the two cricketing nations, he added.
India and Australia could jointly support the exhibition that would travel to major cities like Delhi, Kolkata, Chennai and Mumbai, said Downer .
The foreign minister, himself a keen cricketer, added: "I used to enjoy playing cricket. I was a medium pacer."


text:
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text:
Authenticity Tue, Jun 30, 2015
Happy Wednesday team!
"Nothing is original. Steal from anywhere that resonates with inspiration or fuels your imagination. Devour old films, new films, music, books, paintings, photographs, poems, dreams, random conversations, architecture, bridges, street signs, trees, clouds, bodies of water, light and shadows. Select only things to steal from that speak directly to your soul. If you do this, your work (and theft) will be authentic. Authenticity is invaluable; originality is non-existent. And don't bother concealing your thievery - celebrate it if you feel like it. In any case, always remember what Jean-Luc Godard said: "It's not where you take things from - it's where you take them to." – Jim Jarmusch
Here is a quote from Jim Jarmush (If you have not seen Ghost Dog, I HIGHLY recommend it). I think it is a great quote that not only applies to people, but "brands" as well. Knowing who you are is an invaluable tool for growth and part of that starts with knowing what you like.
Thanks Everyone, have a great rest of your week!


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|"Uwe Schindler" <...@thetaphi.de>
|RE: [DISCUSS] Build/deploy Maven artifacts outside of Lucene/Solr
|Mon, 23 Apr 2012 21:29:04 GMT
Hi, Thanks for clarification! This was one of the things that I never understood, for me the additional maven build was just magic :-) This powers my opinion, that the so called "maven builds" are simply another way of publishing artifacts and that's important in my opinion, as we are using the infrastructure of IVY, which relies on Maven servers to work (Robert: I know that IVY also supports downloading from arbitrary URLs, but that is missing stability and metadata). Uwe ----- Uwe Schindler H.-H.-Meier-Allee 63, D-28213 Bremen http://www.thetaphi.de eMail: firstname.lastname@example.com > -----Original Message----- > From: Steven A Rowe [mailto:email@example.com] > Sent: Monday, April 23, 2012 11:21 PM > To: email@example.com > Subject: RE: [DISCUSS] Build/deploy Maven artifacts outside of Lucene/Solr > > On 4/23/2012 at 5:09 PM, Uwe Schindler wrote: > > Finally, publishing maven artifacts has nothing to do with maven at > > all. We don't need a maven build to do that! > > The Maven build is there to enable using Maven to check the correctness of the > POMs. I think this is essential. Prior to this, the Lucene/Solr Maven POMs > were *always* out of date, and nobody knew about it. > > > in my opinion, the old way of creating JAR files (which ANT does for > > us) and copying them to the maven servers can be done completely > > without maven > > That's how it's done now. The "maven artifacts" are just the Ant-produced .jar > files, along with the Maven POM files. Copying to the maven servers is > performed using Maven Ant Tasks, which runs under Ant, not Maven. > > > As we are now using IVY, we should maybe do the automated deploy using > > IVY instead of a parallel maven build. > > I don't know IVY - maybe it could serve the same copy-to-maven-servers > purpose as Maven Ant Tasks? > > And again, the parallel maven build is not involved in preparation of maven > artifacts or in pushing them to Maven Central. > > Steve > > > --------------------------------------------------------------------- > To unsubscribe, e-mail: firstname.lastname@example.com For additional > commands, e-mail: firstname.lastname@example.com --------------------------------------------------------------------- To unsubscribe, e-mail: email@example.com For additional commands, e-mail: email@example.com
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It is preparing some countries to leave the euro zone
European & US sessions forecast levels: 1.3380/1.3860
Trend Sessions: European: Neutral
US: Neutral/Upward
Market Focus: 9:55 AM Michigan Sentiment.
Daily Strategy: The euro remains under pressure due too the rising talks for the countries with huge debt to leave the euro zone. If some of the countries leave the euro zone the market reactions could be like an earthquake. For today FS Team expects mix trading with slowly dollar gains during the European session.


text:
Since 2007, the Heartland Tank Companies, Heartland Tank Services, Inc. and its sister company Heartland Tank, LLC, have provided complete liquid storage tank services, from erecting and maintaining aboveground steel storage tanks to tank liners and repair. We construct large field erected tanks ranging from 100,000 to 3 million gallons in capacity. Our work ethic and professionalism in delivering the highest quality products and services sets us apart from our competition.
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text:
Clinical Nurse Leader Certification Overview
What is CNL Certification?
Certification is a process by which a non-governmental agency validates an individual nurse's qualifications for practice based on pre-defined standards. The purpose of the CNL Certification is to create a unique credential for graduates of master's and post-master's CNL programs. Candidates who meet all eligibility requirements and pass the CNL Certification Examination will earn the credential of "CNL".
The CNL certification is based upon a national standard of requisite knowledge and experiences, thereby assisting employers, the public and members of the health professions in the assessment of a CNL.
Graduate education is necessary because the CNL must bring a high level of clinical competence and knowledge to the point of care and serve as a resource for the nursing team.
Question? Contact CNC's Staff at firstname.lastname@example.com.


text:
Tree House Brewing Co. to Open New Facility in Charlton
One of the highest-rated breweries in the state is going to be expanding.
The Craft Beer Boston blog states (via the brewery) that Tree House Brewing Co. in Monson is planning to open a second facility in Charlton, with this one being larger in size (45,000 square feet compared to approximately 10,000 square feet in Monson) and including a brewhouse, retail space, a taproom, and an outdoor pavilion. The brewery hopes to start work on the space this spring and could have the new facility up and running sometime in the first half of 2017, at which point the original facility in Monson will be used as a barrel hall and a space for "special projects."
Tree House Brewing Co. has received much praise since originally starting out in Brimfield in 2011; Beer Advocate currently shows that nine of the ten top-rated beers in Massachusetts come from the brewery.
Follow us on Twitter at @hiddenboston
[Related article from our sister site (Boston's Hidden Restaurants): Slideshow--Ten Good Places to Get Beer in the Boston Area]
Labels: breweries


text:
Kolkata, Apr 17: Former India captain Sourav Ganguly on Tuesday revealed that the Pune Warriors management never thought Yuvraj Singh was "captaincy material" after the team's debacle in the 2011 IPL when they finished last.
Ganguly feels that's the reason why Angelo Mathews and Ross Taylor have been preferred as captains ahead of the senior left-hander.
"The management had decided not to make Yuvraj captain again after our first season (in 2011 where the team finished last). They thought he (Yuvraj) was not captaincy material - not the one who could lead the side. It was a decision that was taken after our first season (2011)," Ganguly said.
Mathews was dropped on Monday as Taylor became the franchise's fifth skipper from three seasons and the Kiwi led the side to a convincing 24-run win over Chennai Super Kings.
As it turned out, Steven Smith, who was Mathews' replacement, came up with a match-winning performance with his unbeaten 39 as PWI looked a transformed side.
Ganguly felt PWI would stick to the line-up in future. "The team looked balanced. Dinda did very well, while Rahul Sharma was magnificent. The foreign line-up in Finch, Taylor, Smith and Marsh also looked a settled unit. "I would be surprised if they change the combination for the line-up against Sunrisers Hyderabad," Ganguly said.
The left-hander said the Pune franchise have it in them to make the last four. "They have some big hitters in (Robin) Uthappa, Finch, Taylor, Smith and Marsh who can win on their own. Their bowling in Bhuvaneshwar, Dinda and Sharma also look good.


text:
Product Pathways - Chromatin Regulation / Epigenetics
Histone H4 (D2X4V) Rabbit mAb (ChIP Formulated) #14149
PhosphoSitePlus ® protein, site, and accession data: HISTONE H4
|100 µl ( 10 immunoprecipitations )
|现货查询 购买询价 防伪查询
|carrier free & custom formulation / quantity
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|MW (kDa)
|Rabbit IgG
Species cross-reactivity is determined by western blot.
Applications Key: ChIP=Chromatin IP,
Species predicted to react based on 100% sequence homology: Mouse, Rat, Hamster, Monkey, Chicken, Bovine,
Specificity / Sensitivity
Histone H4 (D2X4V) Rabbit mAb (ChIP Formulated) recognizes endogenous levels of total histone H4 protein. This antibody does not cross-react with other histone proteins.
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala38 of human histone H4 protein.
Chromatin IP
Chromatin immunoprecipitations were performed with cross-linked chromatin from 4 x 106 HeLa cells and either 10 μl of Histone H4 (D2X4V) Rabbit mAb (ChIP Formulated) or 2 μl of Normal Rabbit IgG #2729 using SimpleChIP® Enzymatic Chromatin IP Kit (Magnetic Beads) #9003. The enriched DNA was quantified by real-time PCR using SimpleChIP® Human GAPDH Exon 1 Primers #5516, SimpleChIP® Human RPL30 Exon 3 Primers #7014, SimpleChIP® Human MYT-1 Exon 1 Primers #4493, and SimpleChIP® Human α Satellite Repeat Primers #4486. The amount of immunoprecipitated DNA in each sample is represented as signal relative to the total amount of input chromatin, which is equivalent to one.
Modulation of chromatin structure plays an important role in the regulation of transcription in eukaryotes. The nucleosome, made up of DNA wound around eight core histone proteins (two each of H2A, H2B, H3, and H4), is the primary building block of chromatin (1). The amino-terminal tails of core histones undergo various post-translational modifications, including acetylation, phosphorylation, methylation, and ubiquitination (2-5). These modifications occur in response to various stimuli and have a direct effect on the accessibility of chromatin to transcription factors and, therefore, gene expression (6). In most species, histone H2B is primarily acetylated at Lys5, 12, 15, and 20 (4,7). Histone H3 is primarily acetylated at Lys9, 14, 18, 23, 27, and 56. Acetylation of H3 at Lys9 appears to have a dominant role in histone deposition and chromatin assembly in some organisms (2,3). Phosphorylation at Ser10, Ser28, and Thr11 of histone H3 is tightly correlated with chromosome condensation during both mitosis and meiosis (8-10). Phosphorylation at Thr3 of histone H3 is highly conserved among many species and is catalyzed by the kinase haspin. Immunostaining with phospho-specific antibodies in mammalian cells reveals mitotic phosphorylation at Thr3 of H3 in prophase and its dephosphorylation during anaphase (11).
- Workman, J.L. and Kingston, R.E. (1998) Annu Rev Biochem 67, 545-79.
- Hansen, J.C. et al. (1998) Biochemistry 37, 17637-41.
- Strahl, B.D. and Allis, C.D. (2000) Nature 403, 41-5.
- Cheung, P. et al. (2000) Cell 103, 263-71.
- Bernstein, B.E. and Schreiber, S.L. (2002) Chem Biol 9, 1167-73.
- Jaskelioff, M. and Peterson, C.L. (2003) Nat Cell Biol 5, 395-9.
- Thorne, A.W. et al. (1990) Eur J Biochem 193, 701-13.
- Hendzel, M.J. et al. (1997) Chromosoma 106, 348-60.
- Goto, H. et al. (1999) J Biol Chem 274, 25543-9.
- Preuss, U. et al. (2003) Nucleic Acids Res 31, 878-85.
- Dai, J. et al. (2005) Genes Dev 19, 472-88.
Application References
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- 14149 :
- ChIP Magnetic
Companion Products
- 13534 Acetyl-Histone H4 (Lys16) (E2B8W) Rabbit mAb
- 13919 Histone H4 (D2X4V) Rabbit mAb
- 13944 Acetyl-Histone H4 (Lys12) (D2W6O) Rabbit mAb
- 2591 Acetyl-Histone H4 (Lys12) Antibody
- 2594 Acetyl-Histone H4 (Lys8) Antibody
- 4486 SimpleChIP® Human α Satellite Repeat Primers
- 4493 SimpleChIP® Human MYT-1 Exon 1 Primers
- 5737 Tri-Methyl-Histone H4 (Lys20) (D84D2) Rabbit mAb
- 7003 20X LumiGLO® Reagent and 20X Peroxide
- 7017 6-Tube Magnetic Separation Rack
- 7071 Phototope-HRP Western Blot Detection System, Anti-rabbit IgG, HRP-linked Antibody
- 7074 Anti-rabbit IgG, HRP-linked Antibody
- 7727 Biotinylated Protein Ladder Detection Pack
- 8647 Acetyl-Histone H4 (Lys5) (D12B3) Rabbit mAb
- 9002 SimpleChIP® Enzymatic Chromatin IP Kit (Agarose Beads)
- 9003 SimpleChIP® Enzymatic Chromatin IP Kit (Magnetic Beads)
- 9004 SimpleChIP® Plus Enzymatic Chromatin IP Kit (Agarose Beads)
- 9005 SimpleChIP® Plus Enzymatic Chromatin IP Kit (Magnetic Beads)
- 9006 ChIP-Grade Protein G Magnetic Beads
- 9007 ChIP-Grade Protein G Agarose Beads
- 9672 Acetyl-Histone H4 (Lys5) Antibody
- 9724 Mono-Methyl-Histone H4 (Lys20) Antibody
- 9759 Di-Methyl-Histone H4 (Lys20) Antibody
- 9999 Nonfat Dry Milk
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text:
The special SIT court hearing the 2002 Gulberg Society massacre will pronounce on June 17, the quantum of punishment for 24 convicted in connection with the killing of 69 people including former Congress MP Ehsan Jafri. After arguments on the quantum of sentence came to an end with the final submission by prosecution on Friday, the special SIT court Judge P B Desai had adjourned the hearing to June 13. However, the court was not fully convinced with the submissions and said that there exists no straight jacket formula to decide about the compensation in such cases.
The prosecution has sought nothing less than death sentence or jail term till death for all the convicts while the defence lawyers contested that the incident was spontaneous and there were enough provocations for it. During the trial, riots victim's lawyer had argued that the massacre was a pre-planned criminal conspiracy hatched by the accused to kill minority community members of the Gulberg Society. The defence had refuted the conspiracy theory of prosecution and claimed that the mob resorted to violence only after slain Congress MP Eshan Jafri fired several rounds on them.
The Gulberg Society case is one of the nine cases of the 2002 Gujarat riots probed by the Supreme Court appointed SIT. The incident had taken place a day after S-6 coach of Sabarmati Express was burnt near Godhra train station, where in 58 'karsevaks' were killed.


text:
Product Pathways - Tyrosine Kinase / Adaptors
Ret (E1N9A) Rabbit mAb (PE Conjugate) #68897
PhosphoSitePlus ® protein, site, and accession data: RET
|100 µl ( 50 tests )
|现货查询 购买询价 防伪查询
|carrier free & custom formulation / quantity
|email request
|MW (kDa)
|Rabbit IgG
Species cross-reactivity is determined by western blot.
Applications Key: F=Flow Cytometry,
Specificity / Sensitivity
Ret (E1N9A) Rabbit mAb (Flow Preferred) (PE Conjugate) recognizes endogenous levels of total Ret protein.
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro320 of human Ret protein.
This Cell Signaling Technology antibody is conjugated to phycoerythrin (PE) and tested in-house for direct flow cytometry analysis in human cells. This antibody is expected to exhibit the same species cross-reactivity as the unconjugated Ret (E1N9A) Rabbit mAb (Flow Preferred) #14699.
The Ret proto-oncogene (c-Ret) is a receptor tyrosine kinase that functions as a multicomponent receptor complex in conjunction with other membrane-bound, ligand-binding GDNF family receptors (1). Ligands that bind the Ret receptor include the glial cell line-derived neurotrophic factor (GDNF) and its congeners neurturin, persephin, and artemin (2-4). Research studies have shown that alterations in the corresponding RET gene are associated with diseases including papillary thyroid carcinoma, multiple endocrine neoplasia (type 2A and 2B), familial medullary thyroid carcinoma, and a congenital developmental disorder known as Hirschsprung's disease (1,3). The Tyr905 residue located in the Ret kinase domain plays a crucial role in Ret catalytic and biological activity. Substitution of Phe for Tyr at position 905 dramatically inhibits Ret autophosphorylation activity (5).
- Airaksinen, M.S. et al. (1999) Mol Cell Neurosci 13, 313-25.
- Takahashi, M. et al. (1989) Oncogene 4, 805-6.
- Manié, S. et al. (2001) Trends Genet 17, 580-9.
- Tallini, G. and Asa, S.L. (2001) Adv Anat Pathol 8, 345-54.
- Iwashita, T. et al. (1999) Oncogene 18, 3919-22.
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text: Scio's technology offers the flexibility to produce lab-grown diamonds in size, color and quality combinations that are very rare in nature. Scio produces diamonds for industrial, gemstone, medical and semiconductor applications.Cautionary Note Regarding Forward-Looking Statements This press release contains forward-looking statements that may involve known and unknown risks, uncertainties and other factors which may cause the actual results, performance or achievements of Scio to be materially different from future results, performance or achievements expressed or implied by any forward-looking statements. Forward-looking statements, which involve assumptions and describe future plans, strategies and expectations of the company, are generally identifiable by use of the words "may," "will," "should," "could," "would," "forecast," "potential," "continue," "contemplate," "expect," "anticipate," "estimate," "believe," "intend," "or "project" or the negative of these words or other variations on these words or comparable terminology. These forward-looking statements are based on assumptions that may be incorrect, and there can be no assurance that these projections included in these forward-looking statements will come to pass. Actual results of the company could differ materially from those expressed or implied by the forward-looking statements as a result of various factors. Except as required by applicable laws, the company has no obligation to update publicly any forward-looking statements for any reason, even if new information becomes available or other events occur in the future. SOURCE Scio Diamond


text:
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Ricoh Caplio GX100
Announced Mar 28, 2007 •
10 megapixels | 2.5″ screen | 24 – 72 mm (3×)
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Reviewed Aug 7, 2007Review
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Product description
Announced Mar 28, 2007
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The GX100 has several features to set it apart from the majority of 10MP compacts, most interestingly a 3x zoom lens with a true wideangle capability, covering a range equivalent to 24-72mm on a 35mm camera. The GX100 is also the world's first digital compact to offer an (optional) removable electronic viewfinder, which slips into the flash hot shoe and tilts upwards through 90 degrees. Like the GR-D the GX100 offers 'SLR like' control thanks to twin control dials, raw capture (using the 'universal' DNG format) and a high level of customization options. Unfortunately the GX100 isn't quite as good a camera as it thinks it is, because great features and handling cannot make up for a noisy sensor and questionable processing.
Product timeline
Review, Aug 7, 2007
Aug 7, 2007
Mar 28, 2007
Quick specs
|Body type
|Max resolution
|3648 x 2736
|Effective pixels
|10 megapixels
|Sensor size
|1/1.75" (7.36 x 5.52 mm)
|Sensor type
|Auto, 80, 100, 200, 400, 800, 1600
|Focal length (equiv.)
|24–72 mm
|Max aperture
|Screen size
|Screen dots
|Max shutter speed
|1/2000 sec
|Storage types
|SD/SDHC/MMC card, Internal
|USB 2.0 (480 Mbit/sec)
|Weight (inc. batteries)
|260 g (0.57 lb / 9.17 oz)
|112 x 58 x 25 mm (4.41 x 2.28 x 0.98″)
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The median home value in Lockhart, TX is $157,668.
This is
higher than
the county median home value of $119,900.
The national median home value is $185,800.
The average price of homes sold in Lockhart, TX is $157,668.
Approximately 53.35% of Lockhart homes are owned,
compared to 36.95% rented, while
9.7% are vacant.
Lockhart real estate listings include condos, townhomes, and single family homes for sale.
Commercial properties are also available.
If you see a property you're interested in, contact a Lockhart real estate agent to arrange a tour today!
Learn more about Lockhart Real Estate.
Single story brick house in fantastic neighborhood. Walls are rounded corners, vaulted ceilings and great natural light. Open floorplan that connects cook to all the action. Nice extended, covered patio 10x30. Storage shed stays and will leave above ground pool and trampoline if buyers negotiate and want them both or he will have them both removed. Upgraded dishwasher and range. Range has a double oven perfect for those who like to bake. Replaced toilets to elongated and new faucets in house.
Nice 1.89 acre wooded lot on a paved road with a well maintained 3 bedroom, 2 bath mfg home. Metal roof, decks front and back. Exterior was painted in June 2017. Updated bathrooms and kitchen. Recent flooring through much of the home. Beautiful treed yard, circle driveway. Easy commuting location to Austin, Bastrop, San Marcos, or Lockhart. Apprx 1 mile from SH 130 / Hwy 183 near Lockhart.
Large recently renovated home with 4 bedrooms, 2 full baths, living room, kitchen with granite counters, hickory cabinets, tile backsplash, pantry, gas range, dining area, master bedroom with full bath, utility area, ceiling fans, other renovations include central heat with heat pump, central air, breaker box, siding, flooring, windows, large lot with trees, fenced, storage shed and much more. Easy to show.
Almost 4 acres of UNRESITRCITED LAND with great visibility from Toll 130 and HWY 183. Great for a residential or commercial use since the property has NO Restrictions according to the Owner and County staff. Currently has a 3240 residence located on it and pond in the back. In the Lockhart area. Contact agent for more details!!
Wonderful large brick home in a well established neighborhood with formal living/dining, family room with built-ins, fireplace, kitchen with breakfast area, granite counters, tile backsplash, stainless steel appliances, pantry and open to family room, master bedroom with fireplace, full bath, double sinks, linen closet, walk in closet, large bedrooms, cedar lined closet, utility room, 2 car garage, large yard, fenced, storage shed and much more. Shown by appointment only. Home has lots of potential.
This is a beautiful 3 Bedroom, 2 Bath home with a large backyard. Great open floor plan, and very spacious for the square footage. All kitchen appliances convey except for the refrigerator. The washer and dryer also convey with the home. Conveniently located down the road from SH 130 for quick commute to Austin, Seguin, and San Antonio.
11.1 Acre private setting~One of a Kind Custom Home in Hill Country~4BR/3.5BA~Huge 4-car detached drive thru garage w unfin plumbed living space~4-car Portico~Artisan interior brick walls~Wood/Metal accents~Vaulted Master on Main w claw foot tub & stone walk in shower~Addâl BR downstairs~Granite tops~Lofted upstairs w 2 xtra BR, hardwoods & stunning views~Livestock pond~ICYNENE spray insulation~Durable metal/stone exterior~10 min from town~Under an hour to Austin and San Marcos~Quality build and design~
Open House:
Saturday, 7/1
Large family home. Mature oak trees in Summerside! Open floor plan, w/laminate floors downstairs. Kitchen has full size breakfast area, plus breakfast bar. Formal living and dining areas too. Family room is HUGE w/gas logs in the fireplace waiting for cozy nights/winter family holiday. Master DOWN w/two vanities, separate shower and garden tub. 3 large bedrooms and guest bath upstairs. Backyard with covered patio area, flower and fruit trees, large shed and plenty of space for kids and dogs. NO HOA.
Wide Open Spaces!! 8.6 Acres! Near the community of McMahan! This 3 bedroom/2 Bath home has been tastefully remodeled inside for that rustic look! The office area could be a 4th bedroom. Sheetrock, laminate flooring, mudroom/doggie room. Plenty of room for horses or livestock. Nice soil for gardening! Garden tub, separate shower. Level land with huge, beautiful Oaks! Large storage bldg has electricity and A/C. 30 Amp RV Hookup for guests! Easy commute to Austin and only 10 miles from Lockhart!
2014 custom home resting on 1.51 acres,in the beautiful countryside just outside Lockhart.The Ridge subdivision is a unique 16-lot community,w/a HOA-owned lake and walking path.Open floor plan,6â laminate flooring,solar screens,2â blinds,granite throughout. Seamless granite kitchen counters,custom cabinets made by local craftsman,under-cabinet lighting, tile backsplash,Whirlpool energy-star appliances.Mature trees, on a private & spacious backyard are perfect for entertaining. Shed conveys.
Custom built, beautiful 3/2/2 home in one of Lockhart's most prestigious neighborhoods! Spacious kitchen with tile counters and stainless appliances, built-ins, oversized utility room, extra large bedrooms, and French doors in master leading to back porch! Master offers double vanities, separate shower, and garden tub! Lavish landscaping, established yard, and full sprinkler system on a large lot of 1/3 acre. Superb location and access from Clearfork St. at the rear of property! Shown by appt. only!
Custom home, foyer, living room, fireplace, high ceilings, built-ins, recessed lighting, granite counters, tile backsplash, island, cooktop, built-in ovens, open to dining area, large utility room, master bedroom with fireplace, double sinks, garden tub, shower, walk in closet, built-ins, cedar, safe, bedroom, full bath, office or 4th bedroom all this downstairs, upstairs bedroom, full bath, second living area with many built-ins, 2 car garage, in-ground pool, landscaped/much more, must see to appreciate.
The kitchen and master bed/bathroom are beautifully updated and this home is shining! The downstairs flooring is wood; not laminate, downstairs countertops are granite; upstairs master bath is quartz and a beautiful walk in separate shower. There are four beds and a study or nursery; master is upstairs. CAD says this home is 2180 sq. ft. and it feels so spacious. Utility room. Perfect set up for the person working from home. Fenced rear yard and 2 car garage; children would go to Bluebonnet Elem.
Adorable mid century Bungalow built in the 1940's in quaint downtown Lockhart.Convenient access to great local restaurants, and shops within walking distance.Beautiful original hardwoods inside and extra large family style patio with covered porch for entertaining out back.3 bedrooms, 2 full bath , living room, kitchen with dining area, master downstairs and two other bedrooms upstairs, large lot with trees. close to schools, home needs work but has lots of potential.Vacant and easy to show.
A nice, corner lot with custom 2015 built 3/2.5 home with a few upgrades. The home is sandstone rock on all four sides and even has some accent sandstone on the interior. Kitchen has a 5 burner propane cooktop & a copper farmhouse, apron type sink, a wood burning or LPG fireplace in the great room and the master bath sports a sizable walk in shower. The property is scattered with beautiful Live Oak & Mesquite trees which supports more privacy from neighbors. Easy commute to Austin, SM or Lockhart
Great Home or investment property with open floor plan of living room and kitchen with dining area, gas rage, dishwasher, 3 bedrooms, 1 full bath, master bedroom with half bath, family room, French doors, ceiling fans, one car garage, utility are in garage, gutters, half acre lot with trees, some wood flooring, home has lots of potential.
This lovely two story home has three bedrooms, two and a half baths & sits in a quiet neighborhood just outside the center of town. Home features granite kitchen counter tops, stainless steel appliances, and tiled backsplash. You'll enjoy spending time on the covered patio under the Pecan trees as you sip on tea. The over sized (double) lot provides plenty of space for the kids to play, backyard BBQ's, or maybe in your new summer pool? Storage shed easily stores your gardening and lawn tools. Hurry!
Nice 4 bed, 2 bath rock home in a great location. The garage has been converted for a large family room or 4th bedroom, which adds an additional 390 sqft of living space, bringing the entire home close to 2000 sqft (1993/CAD) Upgraded kitchen with hickory cabinets, granite countertops, & SS appliances. Tankless Water Heater! Floors are tile & wood laminate, but bedrooms 2 & 3 had carpet installed 4/2017! Master tub has a tile surround. HUGE fenced backyard with a storage shed.
Beautiful home with a modern layout available in the Summerside community! Home has an open floor plan, w/ laminate floors throughout. Kitchen has pantry, dishwasher, breakfast nook, & breakfast bar. Living area has a cozy fireplace & has access to the backyard. Master suite has a full bath, that features a double vanity, & separate shower and tub. Additional bedrooms are located on the opposite side of the home. Backyard has a covered patio area, a tree & plenty of flex space. 3D Virtual Tour Available!
Spacious 4 bedroom home with 2.5 baths, 2 dining areas, an office, plus 3 living areas. Covered front and back porches. Large master suite with double vanity and walk-in closet. Granite counters in the kitchen that is open to the family room with a nice fireplace. Privacy fenced backyard, 2 car garage. In the Windridge Subdivision convenient to SH 130.
Beautiful hidden gem with unrestricted and unlimited potential for an additional home, shop, and so much more. Property is private and peaceful, yet still less than 15 min to the heart of the city of Lockhart. A rare find, the property provides custom personal touches throughout the home as it has been remodeled and well maintained.
Southwestern Style Mansion is the Estate of Dollie Cole and has 35.562 acres, over 10,000 sq. ft. of living space in the house, 2 guest houses, pool, tennis court, caretaker home, 6 car garage, large barn, and lake. The construction is unique including a family/kitchen area made of 40' beams and antique lumber from the old Lockhart, TX Cotton Compress. One wing was formerly a restaurant. There are 39 hand carved 9' X 4' doors throughout. It has been used for making movies, TV shows, and large parties.
Early 1900's home in the heart of Lockhart. Close to downtown. 3 bedrooms, 2 baths, 2 living areas. Original wood floors through part of the home. Functioning transom over the entry door, stained glass front window. Detached 2 story building/shop with insulated walls, central A/C, & a half bath. Could possibly be converted into guest quarters or used as a large home office (Austin artist acid stained the floors with unique designs). Lush backyard with an aquaponics system and a spacious covered back porch
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text:
Just when you thought there wasn't enough to worry about, there's now a brand new STI about… and it's pretty nasty.
Scientists discovered Mycoglasma Genitalium – or MG – and believe hundreds of thousands of people in the UK have it and they won't even know. Arghhh.
The bacteria has been around since the 1980's, so you're probably wondering 'why am I only hearing about this now?'. Well, Possibly because more than 90 per cent of the MG-positive men and more than half the women did not report any warning signs.
This new study has finally found a link between the bacteria and having sex. So what are the symptoms, I hear you ask. Well, as stated previously some don't get any symptoms at all, but it causes discharge and painful testicles in men and for women, bleeding after sex.
This new report published in the International Journal of Epidemiology, by University College London researchers found that the infection is transmitted through unprotected sexual activity, and plays a role in pelvic inflammatory disease, infertility and ectopic pregnancy.
To reach their findings, researchers examined urine samples of 4,507 men and women between the ages of 18 and 44 who were sexually active with at least one partner. Of these participants, 48 women and 24 men were diagnosed with the new STI.
The STI peaked at 2.1 per cent in men between the ages of 25 and 34, while in women it peaked at 2.4 per cent in 16 to 19 year olds.
The researchers wrote: "For both men and women, MG was strongly associated with reporting sexual risk behaviours (increasing number of total and new partners, and unsafe sex, in the past year)."
What makes it all the more terrifying is the fact it will be years until we have routine testing available at your GP or sexual health clinic and we don't yet know what the implications of having the STI will be.
According to the study, it's no real surprise that MG is most common in people that have had more than four sexual partners in a year.
Their advice is simple, practice safe sex and try not to sleep around too much. Simple.


text:
Cry Wolf!
About a month ago I was asked by my good friend Sarah Wolf to help brand her emerging promotional event planning company. She has been deep into the Austin scene for a while working on events such as Austin Fashion Week, SXSW parties, along with local companies, artists, and musicians. She has always had a cool style and a good eye for aesthetics, and with a name like Wolf, I couldn't pass it up.
We went through a few iterations, and finally ended on:
I am quite happy how it turned out, and Sarah is great to work with.
We also put together a micro-site that launched yesterday, be sure to check it out at www.sarahkwolf.com. If you are in the Austin area and looking to put together an epic shindig fitting for the Austin scene, cry Wolf! and you won't be disappointed.
- Visit www.sarahkwolf.com
- Follow Sarah on Twitter
- Friend Sarah on Facebook
- Connect with Sarah on LinkedIn
Design cheers,
The real reason Twitter has bandwidth problems
I have found the secret of why Twitter has bandwidth problems, and why you can't seem to get away from the famous "Fail Whale." If you look closely, you'll notice...
... the birds are flying in different directions! They obviously can't get anywhere if they keep that up.
Quick cheers,
Hey Absolut, Now You're Just Mocking Me
This is an update to my recent charge for Absolut Vodka to make use of an ideal outdoor space in downtown Dallas.
I roll out of bed this morning, get ready, fend off my dogs at the door, start my walk to work and, right when I exit my building, get slapped in the face by Absolut Vodka.
Being encompassed by outdoor advertising every day, I enjoy it when the large vinyl building ads change. I take note of the message, the brand, the placement, the creativity, and the effectiveness (One such ad [seen below] is promoting that their cell phone has a built-in camera! A CAMERA IN A PHONE?! INSANE! Talk about differentiation!). So this morning I walk outside and see the top of a new bright-pink, very nondescript ad. I think, "Oh that's cute. It must be for some luxury good or a new Brittany Spears perfume."
I walk around the corner to get a better view, only to notice a URL at the top the ad reads "facebook.com/absolut."
Yes they did.
Just ONE BLOCK from the holy grail of Absolut Vodka outdoor advertising, which I wrote about 4 days ago, they decided to put up a new ad. Obviously Absolut understands the market and is willing to pay big bucks for outdoor advertising in downtown Dallas, otherwise they wouldn't have put this new one up. Likewise, they obviously don't read this blog, or else they would have found the ideal building for their campaign just one block east of their current ad.
Absolut, I'm disappointed. How could you guys have missed this?
Disappointed cheers,
Look out Helvetica, there's a new font on the block.
UPDATE (06/04/10): Due to the request of Thorsten at helpworx, I have updated Knightereau to include German characters as well as some legal glyphs. They new goodies include: Ää Öö Ëë Ïï Üü ß ® © ™.
I have always been a fan of receiving little notes from my wife, Kristi. Mostly because of the overly generous things she has to say in them about me, but also because I think she has really cool handwriting. It is fun, whimsical, but also neat and clean.
I have always told her it would make a cool font.
So flashforward into our first year of marriage. It is my birthday and I awake to a series of large notes placed throughout the apartment wishing me a happy birthday from various items in house, such as "I'll try to multiply what's in here today! - Wallet" and "I promise to get the water the perfect temperature for you. - Shower" and so-on as I begin my day. (Kristi leaves the apartment most days before I am even out of bed. Thank you 9am work schedule.) So the next day I brought all of the notes up to the office and scanned them in and that night began working on the Muhammed Ali of fonts, promising to change the type game forever.
I had Kristi fill in the missing characters and glyphs, and even decided to throw in a couple of her signature moves, hearts and a diamond-eyed smiley face.
A few weeks later, Knightereau was born. (Knight + Dansereau = Knightereau in case you missed it.)
And now, I offer this to all of you so that you may go out and spread the good news of a professional, hand-written font. (And you can now ghost write Kristi's personal notes... nobody will know it wasn't her!)
Not every glyph is in here (we left out a few like the tilde and Yen symbols), but if you are looking for a certain one just let me know and I can add it.
BTW, if you don't know already, Kristi has her own knitting/cooking/reading blog over at www.SugarAndCaffeine.com and also sells hand-made items through her Etsy store. Check them out. They are rad.


text:
2001 Toyota Highlander Questions
Get answers to questions about your 2001 Toyota Highlander at RepairPal. Find solutions, diagnose problems and get back on the road.Refine by vehicle
This just recently happened.
started out idling slow now it idling very high
My car shows codes P420 and P1150 after having P1135 A/F sensor Bank 1 Sensor 1 replaced. Now dealer is saying I need to replaceexhaust pipe to repair leak. Est. of repairs is 1300. Any one know about this stuff?
My 2001 Highlander has 2 issues. If I start the engine with the heater on it squeals like a belt issue. Soon as I turn heater off it quits. Sound like a belt? I have an sound similar to an exhaust leak, more like a loud hum. Irritating if sitting in the back seat. A quick check does not appear to be exhaust. Noticed it quiets when turning wheel to the right. Could this be CV? Anyone with a similar problem that's been corrected that could shed some light. $ are tight, trying to avoid unnecessary service call.
using a quart every 300 miles. none on the pavement. slight smoking from tailpipe
evapouration emission control system purge flow is malfuntioning
I was decelerating and coming to stop on a very slight decline and the engine just suddenly shut off. I glanced at the dash and all the sensor indicator lights were on. I pulled over to the side and the engine started up again with no problem. This is the first time it has happened. I'm just paranoid that this could happen again while traveling on the freeway. Vehicle is well maintained with 144,000 miles.
Recently, I noticed an odd situation with my AC -- when the dial for tempearture is rotated all the way for the coldest temperature, the air comes out HOT. If I rotate the dial "one click" clockwise, it comes out cold, but NOT as cold as it did before. What is wrong with the AC unit?
The SUV is in good shape; however, it's 9 years old with 98,000 miles on it. Now, the glove compartment has locked up on me and will not open! It has my license in there and I'm unable to drive with this massive inconvenience!
I was told the thermostat controller is out.
When car is running, it sounds like there is one of those cans that people put on the end of their exhuast pipe to make it sound muffled, except this sound is coming from under the engine. It sounds like an exhaust problem, like there is a hole in the muffler, but upon viewing, I can see no visible leakes or holes. It almost sounds like my muffler has a huge hole in it, but I can see anything and it seems to be coming from under the engine?????
summary evaluation indicated some problem with the fuel / air control mileage on car is 46,000 mi.
What is the recommended mileage at which the timing belt should be changed on a 2001 Highlander? Cost in South SF Bay Area Calif?
check engine light has been a constant problem for the past 3-4 yrs. 01" highlander, 77000 miles, has had o2 sensors changed and fuel mixture sensors changed over this time. Light has come on again(need to have this one read), is this a common problem for this year? Up to the first 5-6 yrs never a problem.
What is a fair price to replace the air condensor in my toyota highlander?


text:
With the right author, a book can be big news. Just look at the past few weeks: Russell Brand has used one to espouse his views about the dismantling of the country's creaking political system and gained blanket media coverage in the process; and so many flocked to see Lena Dunham launch hers alongside Caitlin Moran at the Southbank Centre last Friday that, as Moran announced on Twitter, the traditional post-event signing was called off a couple of days before. Dunham's Not That Kind of Girl might have fared rather better with the critics than Brand's Revolution ('long-winded, confused and smug,' as one detractor pronounced), but it's a dead cert that, in either case, booksellers' ears were more attuned to the rattle of cash than the perfect metaphor.
And if they happen to run short of Dunhams and Brands? Well, thanks to Super Thursday — the date in early October that sees the book market flooded with Christmas-friendly goodies — there are plenty more opportunities to rake in the readies. The cream of this year's crop ranges from the autobiographies of sportsmen such as Roy Keane and Kevin Pietersen and entertainers John Cleese and Ray Winstone, to hard-boiled crime from Martina Cole, Gillian Anderson's debut novel, and Opal Plumstead, the 100th book by beloved children's author Jacqueline Wilson.
So, there you are, working out who gets what (a Hairy Bikers diet book for your auntie, John Lydon's Anger is an Energy for your boss). All you have to do now is get it. But here's where the real choice begins. Will you pop down to one of the few remaining chains, such as Waterstones, Daunt Books or Foyles? Will you seek out your friendly independent? (See a list of London's most celebrated bookshops overleaf.) Or will you simply open a new tab on your desktop and head to Amazon — speedy, easy and, if you're a member of the online retailer's Prime scheme, with free delivery?
Whichever way you choose to buy your books, you'll be participating in a situation that tests to the limits the theory that nature's most stable shape is a triangle. For book publishers, bricks-and-mortar retailers (aka bookshops) and Amazon are involved in a tense, three-cornered struggle in which it often seems that all but the most blockbusting authors are the casualties. Many writers now openly acknowledge that the idea of being paid for one's writing, certainly to any reasonable standard or for any length of time, might soon seem like a quaint notion from a bygone era. In a paradoxical development, writers often supplement their royalties by teaching on writing courses (Hanif Kureshi, for example, lectures at Kingston University); in other words, they're prepping other people to be as potentially penniless as they are.
The cost of books has been a hot issue in publishing ever since the collapse 20 years ago of the Net Book Agreement, which set the price of each title so that it cost the same wherever you bought it. But Amazon's dominance in the market has taken that to extremes. An example: a couple of weeks ago, a Twitter ripple alerted me to the fact that Building Stories, an extraordinary graphic novel by Chris Ware, which takes the form of individual pamphlets and magazines packaged in a large and beautiful box, was being sold on Amazon for £7.99. Its initial publication price was £30. What can I say? I immediately ordered a copy. But bumper bargains such as this one have worrying implications for the long-term financial viability of the writing life.
For publishers — and, by extension, for writers — Amazon is both a blessing and a curse. The consistency with which it makes titles across genres and formats readily available, and its deep discounting, attract legions of customers; and it has also turned countless readers into writers with its user-friendly self-publishing model. But many in the industry believe it also abuses its power. The fragility of the relationship between the people who make the books and the people who sell them has been starkly illustrated by the dispute that kicked off earlier this year between giant publishing corporation Hachette, whose authors include Donna Tartt and JK Rowling, and Amazon. Much of its detail is drily arcane, but the crux is that Amazon would like to make ebooks, of which its market share is around 64 per cent, greatly cheaper. This is opposed by Hachette, which would like to retain control of pricing and argues, in any case, that more than 80 per cent of the ebooks it publishes are $9.99 (£6.25) or lower.
But what took this story off the business pages and into a wider arena was the decision in August by more than 900 writers — the majority not even published by Hachette companies — to send a lengthy and painstakingly reasoned letter to Amazon board members. In it, writers including Philip Pullman, Malcolm Gladwell, Mark Haddon, John Grisham, Stephen King and Tartt protested about the sanctions imposed on Hachette titles, which have included removing the pre-order facility, delaying shipping and introducing pop-ups to redirect customers to non-Hachette titles. 'Collectively,' they wrote, 'we have sold more than a billion books. Amazon's tactics have caused us profound anguish and outrage.'
Appearing on Newsnight at around the same time, bestselling thriller writer Lee Child accused Amazon of treating authors as 'collateral damage' (Russell Grandinetti, Amazon's senior vice president, has reportedly referred to them as 'the only leverage we have'). Child employed a slightly chilling metaphor: 'If you have a good friend who is misbehaving, you don't immediately shoot them in the head and bury them in the woods. You take them aside and say, "Come on, pal, you're out of line, shape up and behave properly." That is what those authors are doing. That's what we're saying.'
The dispute rumbles on, although a resolution might have been hastened by a recent agreement over ebook pricing between Amazon and another publishing powerhouse, Simon & Schuster, whose president and CEO Carolyn Reidy swiftly communicated the good tidings to her authors. The details remain confidential, but it's understood that Simon & Schuster will have greater control over ebook pricing, though Amazon has granted what it called a 'financial incentive' for them to keep those prices low. 'Our new deal,' she told them, 'assures that your books will be continuously available for sale at this major retailer through this year's holiday book-buying season and well beyond.' And there's the nub: nobody wants their books not to sell over Christmas.
Separately, legendary literary agent Andrew Wylie told a Canadian writing festival that he thinks the tide is turning in publishers' favour. 'It is a set of terms dictated by a digital trucking company, and the publishing industry, until now, has cowered and whined... and given Amazon pretty much everything they want,' said Wylie, who also referred to the retailer as a 'sort of Isis-like distribution channel'. 'Now I think that's going to stop. Hachette, to their great credit, drew a line in the sand and didn't fold… The deal that Simon & Schuster cut with Amazon... is pretty good for authors. And there is a good chance, in my view, that Amazon will be told, "You either do business on our terms, or we're going to develop other channels of distribution." '
Of interest, too, is a change in European VAT regulations: from January next year, the retailers of ebooks will have to apply VAT at the rate of the buyer's country, rather than the rate of the country where they have their headquarters. In other words, if you are Amazon (or, indeed, Netflix), your Luxembourg address allows you to take advantage of that country's three per cent VAT rate; from now on, sell a British reader an ebook and you will have to cover our rather stiffer rate of 20 per cent. It doesn't take a genius to work out that someone's going to have to make up the difference.
Keen readers would be forgiven for not wanting to look up from their books to grapple with such minutiae. But when you're doing your Christmas shopping, remember the wonderful benefits of bookshop browsing — particularly in evidence in the capital. Wander through the brand-new, magnificently airy and well-stocked Foyles on Charing Cross Road; attend one of the intimate readings or signings that virtually all bookshops now arrange, often free of charge; let your imagination supply you with a wonderful story in Peckham's Review bookshop or Watermark Books at King's Cross, whose booksellers often nab authors to sign copies before they get on a train. Ask a member of staff in any of London's bookshops to recommend you a new book and you'll likely still be there half an hour later. None of this is available if you stay at home. And although everyone loves to grab an internet bargain or circumvent the nightmare of busy Tubes and crowded streets, bear in mind that a healthy book trade — both on and offline — is the best way to make sure the books of the future actually get written. ESReuse content


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Firequake 2014 480p BluRay x264-mSD
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Firequake 2014 480p BluRay x264-mSD
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This is what the pattern says, and I just don't understand. I have completed the sole, and this is for the top of the toe.
Knit English rib knit 11 rows. In the 12th (knit) row knit 8 loops, and then make 8 decreases, knit and purl loops knit together. Return the work and knit by shawl knitting, at the end of every row knit 2 loops together with a lateral part of a front part."
I got the the english rib down, its the 12th row I just don't get. There are 2 pictures here from the pattern, one before the 12th row, one after. Any ideas of how this could be reworded so I can finish it up?
PS, it's 31 stitches total.
Here are the pictures
Must be translated by google translate... here's my interpretation -
k8, dec 8 times with k2tog (or p2tog). Continue in pattern and at the end of every row k2tog. See if that might work, but yes, a picture would help, or if you have the name of the pattern we might be able to find it somewhere.
Thank you. I am really hoping to get a most likely possibility to avoid redoing a bunch. I did post the pictures in a reply
They didn't show up, check your links again.
Try these instructions for posting a picture.http://www.knittinghelp.com/forum/showthread.php?p=1118273#post1118273
Can you also tell us the pattern name or post a link to the pattern?
Ok, here is a direct link to the pictures.
I don't have a link to the pattern, it's one I bought from etsy. Obviously a mistake. The seller/writer is helpful by email, but can't explain this any other way.
I'm not sure where the 8 decreases are in row 12 either. The photo looks like you knit every row over the center 8sts, knitting 2tog at the end of every row so that you knit the instep and attach it to the sides of the bootie at the same time. In the first picture there seem to be 12sts on the right needle and 9sts on the left needle but maybe I'm not seeing all the sts. Should be 31 total so maybe there are 2 more hiding on the left needle?
Yeah, I agree with Salmonmac, looks like the '8 decs' aren't done on one row, but as you go along to join the side sts to the top stitches. Is there a picture of the finished one on etsy?
Here's the completed project picture, for those interested.
Those are so adorable and they look like they'll stay on a babies' feet too.In the photo of the completed bootie, at the toe area, it look like there is a decrease row (row 12?) after the last row of ribbing. It looks like the k1p1 are knit together across maybe 16sts to give you the 8sts on the center needle shown in the first photo you posted. Maybe that's the missing decrease of 8sts.


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With Instructables you can share what you make with the world, and tap into an ever-growing community of creative experts.
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DIY Arduino Battery Spot Welder
I have a very similar project coming up, it's great to see a step by step! Thanks very much.
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Conference Room Soundproofing
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awesome 5'x5' giant art from shower curtain
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IKEA USB lamp hack
Science fair: How accurate is the AC line frequency?
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Embedding a Fusion 360 (3D) model on your Facebook page
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Assembly Instructions for Reactor Core, DIY Arduino Programmer
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Phoenix Sky Harbor announces new flight to Frankfurt, Germany
World travelers at Phoenix Sky Harbor are getting more direct access to Europe, as planes will soon be flying between the desert and Frankfurt, Germany.
113° | 88°
92° with sun and clear skies
Ron Howard to step in as director for Han Solo 'Star Wars' film
How to get rid of Arizona scorpions, spiders and bees
Here are six tips to guide you toward pain-free travel
Arizona police chief fired after verbal exchange with mayorSouth Tucson Police Chief Michael Ford was fired a day after South Tucson Mayor Ildefonso Green blamed him for being a source in negative news articles.
Flake, McCain, mulling Senate health care bill, mum on positionsSens. John McCain and Jeff Flake on Thursday said they were studying a new Senate health care proposal repealing much of Barack Obama's health care law.
Live blog: Phoenix fails to drop below 90 degrees for two daysIn case you're somehow unaware, Arizona is expected to get hit by a heatwave in a big way this week that will send the temperatures soaring.
Arizona AG warns of air conditioning scams during record heatThe attorney general's office is warning Arizona residents to keep an eye out for air conditioning repair scams as the state endures record temperatures.
Freeways re-open after brush fire causes closures in north PhoenixCrews are battling a rapidly growing brush fire along the Loop 303 freeway in north Phoenix that began around 12:45 p.m. Thursday west of Interstate 17.
How to get rid of Arizona scorpions, spiders and Africanized beesIn Arizona, three types of summer bugs tend to be especially frightening: Africanized bees, poisonous spiders and scorpions.
After rapid growth, Lyft formally opens new hub in PhoenixRide-sharing service Lyft officially opened its Phoenix hub Thursday morning, after a year in which the company noted it contributed nearly $40 million to the area economy.
Former Arizona Rep. Ann Kirkpatrick mulls another run for CongressFormer U.S. Rep. Ann Kirkpatrick is considering a possible run next year for Arizona's 2nd Congressional District.
After Comey threat, Trump tweets he has no tapes of conversationsWeeks after threatening former FBI Director James Comey with supposed taped conversations, President Donald Trump has tweeted those tapes do not exist.
Ron Howard to step in as director for Han Solo 'Star Wars' filmThe untitled "Star Wars" film that will focus on the roguish smuggler Han Solo was not without a director for long. Ron Howard has stepped in to the role.
Main Street Minute: Banking, education jobs featured at career fairJobs in banking and education are among the openings available at a career fair in Phoenix on Thursday.
Coconino Forest officials in Arizona add to fire restrictions listCareless campers and the heat wave across much of the state has led to tougher restrictions in a northern Arizona forest.
Record Arizona heat is deadly for your petsFive deaths are attributed to the heat in the Valley. For your animals, this kind of heat can be just as, if not more, dangerous.
Amazing human light show wows the crowd at 'America's Got Talent'Dancers wearing colorful lights demonstrated some alternative fun to the crowd as they danced to Bruno Mars' "24K Magic" and Deorro's "Five More Hours."
ASU researcher hopes shade-tracking tool will help pedestriansTo keep cool, it's important to stay in the shade. One Arizona State University researcher thinks the latter is more important than some people realize.
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Iran says needs 20 nuclear sites: report
By Ramin Mostafavi
TEHRAN (Reuters) - Iran said on Saturday it needed 20 uranium enrichment plants to provide fuel for its nuclear power plants, an announcement likely to heighten tension with six major powers over the Islamic state's nuclear ambitions.
"To provide fuel for our nuclear power plants, we need to have 20 uranium enrichment plants," the official IRNA news agency quoted Ali Akbar Salehi, head of Iran's Atomic Energy Organization, as saying.
In a defiant response to last week's International Atomic Energy Agency vote rebuking Iran for building a second enrichment plant in secret, Tehran said on Sunday it would build 10 more sites like its Natanz underground one monitored by the
Iran has one nuclear power plant, under construction by Russia. Analysts say Iran will need many years if not decades for such a major expansion of its enrichment capability.
The IAEA resolution urged Iran to stop all activities related to enrichment, allow unfettered IAEA inspections and guarantee it is not hiding more sites.
Western powers have warned Iran it is rapidly approaching an end-of-year deadline to accept a U.N.-drafted nuclear fuel deal which calls on Tehran to send 75 percent of its low-enriched uranium (LEU) from Natanz to Russia and France to be turned into fuel for a Tehran medical research reactor.
The proposal to farm out most of Iran's LEU reserves is aimed at minimizing the risk of the country refining the material to the 80-90 percent grade suitable for a bomb. Continued...


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UPDATE 2-BoE's Carney warns of $7 trillion green infrastructure need
* Says $5-7 trillion investment over 15-20 years needed
* Says green finance to be big part of G20 discussions
* Carney does not comment on UK Brexit aftermath (Recasts, adds comments on need for infrastructure investment)
By Matt Scuffham and Fergal Smith
TORONTO, July 15 (Reuters) - As much as $7 trillion will need to be spent building new infrastructure around the world that will make it possible to cut carbon emissions over the next 15 to 20 years, Bank of England Governor Mark Carney warned on Friday.
Carney, speaking with Canadian Environment and Climate Change Minister Catherine McKenna at an event in Toronto, said measures to finance green initiatives would form a major part of this year's G20 summit in China in September, and encouraged investors to back them.
"In terms of what is the magnitude of clean energy or lower- carbon energy infrastructure and cleaner water sanitation, etc., that will be put in place over the next 15 to 20 years ... it's somewhere in the order of $5 to $7 trillion," Carney said. "The question is how much of that is going to be financed through capital markets."
China, one of the world's biggest greenhouse gas emitters, is eager to be seen taking a leadership role in global action to combat climate change and has said it will push for efforts to encourage green investment while leading the G20 group of developed and emerging market countries.
Carney said the Bank of England had been working with the People's Bank of China over the past 18 months to develop a "green" bond market that could finance environmentally friendly projects, part of a broader set of initiatives. Continued...


text:
Для получения актуальных цен по гостинице Karterados Beach Apartments, пожалуйста, укажите интересующие вас даты и выполните поиск.
We have 5 self-contained beach apartments for rent.Traditionally built amidst vineyards and groves and only 100 metres from Karterados beach, these apartments are especially suitable for couples looking for a quiet and relaxing rural setting. The swimming pool is surrounded by a lush garden and a barbeque area is available for the use of guests. Each apartment is completely self-contained and is fitted with air-conditioning, TV, safebox.The fully-fitted kitchen has a cooker with an oven and a fridge / freezer, WiFi Internet Access is available throughout the Property. There is a double bed in a loft sleeping area with a window with a sea view where one can enjoy the night.Sky and listen to the lull of the waves lapping on the shore. The beach is very quiet and unspoilt and one can admire the unusual cliff formations whilst swimming in the inviting sea.
Номеров: 28


text:
Artist-designer Pascal Anson has been chosen to have his artwork painted on a fleet of British Airways planes flying in and out of London
during the 2012 Olympics.
Anson, 38, beat hundreds of amateurs and professionals with his idea, which will be developed with help from Tracey Emin.
Details of how he has interpreted the competition theme of Olympic values will be revealed when the first jet has been transformed next year.
A series of planes including the Boeing 747 will be painted their entire length. The Kingston University lecturer, who is a competitive club swimmer, said it was a chance to work on a giant canvas. His previous biggest work was customising his car with wood-effect vinyl.
"What I want to try to do as an artist is to change people's perceptions of the way the world is. I want people to think about things we take for granted and look again," he said.
Emin said: "Pascal presented a clear and concise idea that we all responded to immediately. If I saw this aircraft on the runway, I'd definitely want to be on it."
Mr Anson, of Shoreham near Brighton, has developed products and featured in Design Museum exhibitions.
Residents under the Heathrow flight path have criticised Richmond council for scrapping its noise complaints hotline before BAA trials a new runway system.
Two runways will operate simultaneously in an attempt to reduce the time planes have to circle before landing. The council said residents could call BAA direct but Anne Cochrane, of the Barnes Community Association, said: "If this is going to be a trial you need someone impartial answering your calls." The first three-month trial starts in November.Reuse content


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Grand Hotel Cadenabbia offers panoramic views from its rooftop terrace with swimming pool and bar.Rooms are air conditioned and come with satellite TV, a minibar, and safe.Free Wi-Fi is available in the lobby.The Grand Hotel's restaurant serves specialities from the Lombardy region. You can enjoy meals out on the terrace with a view of Lake Como.Set in Griante, the hotel is a 5-minute walk from Cadenabbia ferry port for boat trips across the lake. Parking is free.NOTE:Tourist tax will be charged when you check into your hotel (approx. euro 2 pppd)
The Hotel is located on the shore of Lake Como, next to the botanic gardens of Villa Carlotta.


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The diversity of jobs and fields at CERFACS leads to the creation of multidisciplinary teams and the emergence of transversal themes as well as flows of ideas and means for application far from their original field.
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Practical trainings to software developed or co-developed by CERFACS (AVBP, OpenPalm, DSCLIM, CESC, OASIS) are included in this program.


text: The Antwerp Diamond hotel is situated in the residential neighborhood behind the diamond quarter and the large city park. Although it still has a very central location the vicinity is very peaceful. It takes a 15 minutes walk to reach the Central Station and the Meir shopping street and a 25 minutes walk to get into the old city.


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VideoHive Particle Effect 5 Underwater 2366947
After Effects Project \ Logo Stings \ Water
After Effects Project - Particle Effect 5 Underwater 2366947 by berol @ VideoHive
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text:
Jonathan Trott's return home, because of a stress-related illness, means - as one of Joe Root or Ian Bell replace him at number three - a batting position opens up in the middle order for the second Test.
Jonny Bairstow, Stokes and Gary Ballance will be the three contenders, all in their early 20s, jostling to join England's Ashes campaign in Adelaide.
Stokes, like Ballance uncapped at Test level, has the added advantage of being an all-rounder - a significant factor perhaps, at a venue where the bowlers seem sure to have to work hard for their wickets.
He has the opportunity to demonstrate his all-round talents in the two-day match starting at Traeger Park against a CA Chairman's XI on Friday.
"Obviously, there's going to be a place up for grabs, and this game does come at a good time for us for the selection reasons," said the 22-year-old.
"There's three guys trying to take the chance to get that spot, and these days are a good chance for one of us to put our hands up and get in there for Adelaide."
It is less than 10 months ago that Stokes' England future was beginning to look decidedly dicey, after he and all-rounder Matt Coles were sent home from an England Performance Programme tour of Australia for disciplinary reasons.
Persistently breaking curfews by staying too long in the bar was the problem then. But Stokes insists he is ready to make the most of his second chance - if it comes in Adelaide.
"Definitely - as everyone else will be, who didn't play in the first Test," he said.
"Everyone's going to go out there and make sure they put their hand up and prove a point that they want to be out here and be in that second Test match.
"Whoever does take that role will definitely have the skills to come in and fill that spot.
"If it's not me I'll wish them all the best."
England need to put their first-Test defeat behind them to stay in with a realistic chance of winning the Ashes for a fourth successive time.
Stokes, meanwhile, is trying to forget his past mistakes too.
"I think, when I did get back (from Australia last winter), I set out to put everyone's mind right - making sure that they knew that I did want to play for England and get back into the team.
"I think I've done the right things and gone about it the right way.
"Here I am today, so it's brilliant."
England have yet to announce whether they will rest captain Alastair Cook this week - along with first-choice Test players such as Kevin Pietersen and James Anderson.
But they will need to gather as much evidence as possible about who to pick at numbers three and six in Adelaide, as well as working out their best option as third seamer there.
Possible England team versus CA Chairman's XI at Traeger Park: MA Carberry, IR Bell, JE Root, MJ Prior (Captain), GS Ballance, BA Stokes, JM Bairstow (wkt), GP Swann, ST Finn, MS Panesar, WB Rankin.
- More about:
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Voting Rights Experts Debrief on First Presidential Election after the Shelby SCOTUS Decision
On November 16, 2016, the Congressional Voting Rights Caucus' hosted Reverend Dr. William Barber, President, North Carolina NAACP; Maria Urbina, Vice President of Politics and Campaigns, Voto Latino; Ari Berman, Writer and Author, The Nation; Barbara Arnwine, Esq., President and Founder, Transformative Justice Coalition; Ben Ptashnik, Executive Director, National Election Defense Coalition and Symone Sanders, Democratic Strategist and CNN Political Commentator to discuss the effects of voter suppression tactics during the most recent post-Shelby election and how Congress must work together to ensure the full participation of eligible voters moving forward.
Rev. Jesse Jackson Joins Members of the Congressional Voting Rights Caucus to Urge Voting Rights Action
On June 24, 2016, Reverend Jesse Jackson joined members of the Congressional Voting Rights Caucus on the third-anniversary of the Shelby v. Holder Supreme Court decision that left it to Congress to update the historic Voting Rights Act.
Read More
Voting Rights Caucus Launches in May 2016
43 Members of Congress launched the Congressional Voting Rights Caucus on May 24, 2016 to call on Congress to finally update the 1965 Voting Rights Act after the Supreme Court struck down key provisions in 2013.
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Representative Bobby Scott
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text:
The environment secretary, who was widely regarded as the only MP with a chance of defeating Mr Brown, had come under sustained pressure to stand.
The attorney general, Lord Goldsmith, a Blairite, said yesterday that he was "sure" the chancellor was the next prime minister. But John Reid, the home secretary, and his predecessor Charles Clarke, are refusing to rule themselves out as potential candidates, leaving the door open for a challenge. Few believe either could win, but Mr Clarke has said that the chancellor could face as many as three other candidates. Mr Brown's allies say they have already signed up 217 Labour MPs. Only 35 have refused, and a further 93 are apparently undecided.
Mr Reid told GMTV yesterday that it was not appropriate to discuss the issue until Mr Blair stood down, particularly at a time when Labour had to focus its energy on fighting for votes in the Scottish, Welsh and local elections. But he added: "By saying that I won't discuss it, by definition you don't rule in or out."
Mr Miliband dismissed the long-running speculation that he might stand in an article for the Observer, directly tackling suspicions that he had not clarified his position in case Mr Brown stumbled in the next few weeks. "I said three years ago that I would not be a candidate for the leadership. I meant it and have not wavered from that view. I certainly am not in the business of waiting to pounce on local or Scottish and Welsh election results to change my mind," he wrote.
"I will vote for Gordon Brown to lead Labour's drive. I have watched him and worked with him for nearly 20 years. He has in the last 10 years done great things for living standards; no one is better qualified to lead across a wider canvas."
Lord Goldsmith told Sky News' Sunday Live programme: "We are going to have a very, very strong prime minister, I am absolutely confident about that, behind which the Labour party I have no doubt will unite. I am talking about Gordon Brown, absolutely. I am sure that he will be the next prime minister."
One minister said yesterday: "I don't think there's any anxiety about a contest - if [Mr Reid or Mr Clarke] want to stand they should. Personally I think that would make things pretty clear.
"They are in danger of looking more and more divisive and out of touch if they are not careful. People want to get on with things and be positive."
Mr Brown has said that rivals should feel free to stand, but supporters have indicated that they hope to avoid a challenge from the Labour leftwinger John McDonnell, MP for Hayes and Harlington - whom they believe needs only five more supporters to be eligible to stand - or a last-ditch Blairite bid. The chancellor's backers are keen for him to hold his fire so that he can make an impact in his first 100 days as leader.
Michael Meacher, the former environment secretary who is vying with Mr McDonnell for the support of leftwing MPs, yesterday insisted that their figures were inaccurate. He claimed it was "impossible" for his rival to garner the signatures needed, and dismissed the suggestion that only three MPs were intending to vote for him.
"The truth is that I have 24 signed statements from MPs nominating me. I have also received pledged support from more than a dozen further colleagues who have indicated they will sign up once it is clear the contest is about to start," he said.
Mr McDonnell's team insisted he was still the frontrunner and was confident he could muster sufficient support to stand.
"People have to make up their own minds whether they want a vote, or just want a coronation," said an aide.