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Medscape Reference Reference
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Factor II
Author: Robert A Schwartz, MD, MPH; Chief Editor: Emmanuel C Besa, MD more... Updated: Jul 12, 2012
Clotting factor II, or prothrombin, is a vitamin K–dependent proenzyme that functions in the blood coagulation cascade. Factor II deficiency is a rare, inherited or acquired bleeding disorder. In 1947, Quick and colleagues were the first to describe a deficiency of factor II [1] ; in 1969, Shapiro and colleagues were the first to report a structural prothrombin abnormality.[2] Inherited factor II deficiency is an autosomal recessive disorder that can manifest as hypoprothrombinemia, a decrease in the overall synthesis of prothrombin, or as dysprothrombinemia, the synthesis of dysfunctional prothrombin.[3, 4] Homozygous individuals are generally asymptomatic and have functional prothrombin levels of 2-25%. However, symptomatic individuals may experience easy bruising, epistaxis, soft-tissue hemorrhage, excessive postoperative bleeding, and/or menorrhagia. In true hypoprothrombinemia, immunologic assays correlate well with functional assays in that both reveal low prothrombin values. Heterozygous patients are generally asymptomatic and have prothrombin levels of 50% or greater on both immunologic and functional assays. In dysprothrombinemia, only the functional assay for prothrombin returns significantly reduced values, whereas the immunologic assay reveals normal values. Acquired factor II deficiency can be caused by severe liver disease, vitamin K deficiency, anticoagulant drugs (eg, warfarin), or the presence of an antibody directed against the protein.[5] The gene encoding prothrombin is primarily expressed in the liver[6] and is located on chromosome 11 in the region of the centromere.[7] It is composed of 14 exons and contains 24 kilobases of DNA.[7] The gene encodes a signal region, a propeptide region, a glutamic acid domain, 2 kringle regions, and a catalytic domain.[7] The enzyme gammaglutamyl carboxylase, in the presence of vitamin K, converts the N- terminal glutamic acid residues to gammacarboxyglutamic acid residues. These gamma-carboxyglutamic acid residues are necessary for the binding of prothrombin to phospholipids on platelet membranes. Because measurable prothrombin is present in all individuals with hypoprothrombinemia or dysprothrombinemia, authorities believe that the complete absence of prothrombin is incompatible with postnatal life. Studies of transgenic mice with a complete deficiency of prothrombin reveal embryonic lethality and neonatal death.[8, 9] Aside from the prothrombin deficiencies, another disorder of prothrombin is the prothrombin 20210a mutation. First reported in 1996 as a familial cause of venous thromboembolism, the prothrombin 20210a mutation results in increased levels of plasma prothrombin and a concurrent increased risk for the development of thrombosis.[10] Although the exact mechanism of this disorder has not been elucidated, the prothrombin 20210a mutation involves the substitution of an adenine for a guanine at position 20210 within the 3' untranslated region of the prothrombin gene.[11]
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[12] Prothrombin 20210a has an estimated prevalence of 2% in whites. Additionally. but also as a cytokine and growth factor capable of inducing mitosis and chemotaxis in several different cell lines. located in the aromatic stack region of the protein. A family in San Antonio. Protein C then degrades factors Va and VIIIa to inhibit the coagulation cascade. an enzyme that cross-links and stabilizes fibrin polymers. Thrombin is responsible for inducing platelet aggregation and activating several other mediators in the coagulation cascade. would result in an abnormal folding of the protein and could be the cause for the observed lack of secretion of prothrombin. Substitution of a cystine at residue 44. This may provide the rationale for clinical trials on the use of anticoagulant drugs as adjuvant treatment in patients with chronic urticaria.[13] A study of patients in Turkey revealed the presence of the prothrombin 20210a mutation in 0. mainly directed against the high affinity IgE-receptor Fc ε RI on mast cells and basophils or against IgE. 14] The mutation is more prevalent in those of southern European descent than in those of northern European descent. Thus. was found to have normal antigenic levels of prothrombin but half the normal levels of prothrombin activity. Thrombin also converts factor XIII to factor XIIIa. Several specific missense mutations of the prothrombin gene have been documented. with a subsequent increase in protein expression. Treatment with oral anticoagulants is useful in preventing recurrence in patients with the mutation who have already experienced a thrombotic event. Pathophysiology In the blood coagulation cascade. 25.medscape.[17] A study of cancer patients in the Netherlands found that the presence of the prothrombin 20210a mutation in these patients may increase the risk of venous thrombosis to a level greater than that attributable to the malignancy alone.[22] This proteolytic reaction occurs on the phospholipid surfaces of platelets and requires calcium.[24. an active serine protease. Prothrombin plays a role in a role in chronic urticaria and various vascular disorders.7% of subjects. which resulted in the substitution of histidine for arginine at residue 320. It converts fibrinogen to fibrin.[13. women who are known to carry the mutation may want to avoid oral contraceptives because of the additional risk of thrombosis. 16] One case-control study found evidence of an increased risk of developing an ischemic cerebrovascular event in men aged younger than 60 years with the prothrombin 20210a mutation. prothrombin is cleaved by factor Xa to form thrombin.[23] Decreased levels or a dysfunctional structure of factor II can lead to absent or defective clot formation and dysfunctional platelet aggregation. Chronic urticaria may be associated with the activation of coagulation that is due to the involvement of eosinophils and a tissue factor pathway.[19. and it is rarely seen in Asians or Africans. inducing mitosis and chemotaxis in cell lines.[25] A single guanine-to-adenine mutation was found. 27] These single amino acid substitutions can cause hypoprothrombinemia and/or dysprothrombinemia. 26.com/article/209742-overview This mutation alters the polyadenylation site of the gene and results in increased mRNA synthesis.[25] Two members of a family from Venezuela were found to have undetectable antigen levels and prothrombin activity levels at 4% of normal. and mononuclear phagocytes. Substitution of histidine for arginine at this site resulted in the blockage of factor Xa cleavage. endothelial cells.Factor II http://emedicine.[18] The prothrombin 20210a mutation can be identified without DNA analysis and should be considered in any patient experiencing a thrombotic event without other risk factors. forming a dysfunctional molecule and resulting in dysprothrombinemia. Texas. thrombin functions not only in the clotting cascade.[28] 2 dari 7 3/16/2013 6:14 AM .[10. including smooth muscle.[20] Chronic urticaria is an autoimmune disease found in one half of cases with circulating histamine-releasing autoantibodies.[21] The presence of antiphosphatidylserine-prothrombin complex antibodies and histopathological necrotizing vasculitis in the upperto-middle dermis indicates cutaneous leukocytoclastic angiitis rather than cutaneous polyarteritis nodosa.[15] Individuals carrying the prothrombin 20210a mutation have a 2. with generation of thrombin potentially contributing to an increased vascular permeability. which then polymerizes to form a clot around platelet aggregates.[28] A mutation was identified that had resulted in the substitution of cystine for tyrosine at residue 44.to 3-fold increased risk for developing thrombosis. fibroblasts. Thrombin also has cytokine and growth-factor functions. The prothrombotic effects of thrombin are ultimately suppressed by the binding of thrombin to thrombomodulin on endothelial cell surfaces to form a complex that activates protein C. The arginine 320–to–isoleucine 321 bond is 1 of 2 sites in prothrombin cleaved by factor Xa to form thrombin. 20] Livedo vasculopathy is associated with immunoglobulin (Ig)M antiphosphatidylserine-prothrombin complex antibody.
whereas those with less severe forms can present at any age. MD. Age Patients with severe congenital factor II deficiency present early in life. Acquired forms can be observed in all age groups.[29. Vitamin K deficiency can also be seen in neonates. Contributor Information and Disclosures Author Robert A Schwartz. Sex Males and females are affected equally in cases of factor II deficiency.[31] Acquired factor II deficiency has several possible etiologies. and Sigma Xi Disclosure: Nothing to disclose. Pediatrics.medscape. American College of Physicians. severe liver disease can have a dramatic impact on prothrombin levels. American Academy of Dermatology. Coauthor(s) 3 dari 7 3/16/2013 6:14 AM . MD." is most often seen with systemic lupus erythematosus. bile duct obstruction.com/article/209742-overview Other mutations. University of Medicine and Dentistry of New Jersey-New Jersey Medical School Robert A Schwartz. Vitamin K deficiency can also result in decreased prothrombin levels. 30] Prothrombin Saint-Denis involves an aspartic acid to glutamine substitution at position 552.[35. hemarthroses can occur. Vitamin K is produced in the gut by enteric flora.Factor II http://emedicine.[34] Epidemiology Frequency United States Both congenital and acquired factor II deficiencies are rare. Prothrombin Puerto Rico I involves an arginine to glycine substitution at position 457. International Only approximately 30 cases of congenital factor II deficiency have been documented worldwide. Intracranial bleeding is another serious sequela of this disorder. and levels can be affected by intestinal malabsorption. Professor of Pathology. Death can result because of massive hemorrhage from relatively minor accidents or trauma. sometimes referred to as "lupus anticoagulant hypoprothrombinemia syndrome.[33. Dermatology. affecting various regions of the prothrombin gene. Medicine. and Preventive Medicine and Community Health.[3] Race Factor II deficiency has no known racial or ethnic predilection. MPH is a member of the following medical societies: Alpha Omega Alpha. Rarely. 36] This condition. acquired factor II deficiency can sometimes be observed in patients with lupus anticoagulant. MPH Professor and Head. 34] These patients can develop specific prothrombin autoantibodies that form a complex with prothrombin and cause excessive clearance of prothrombin from the body. Finally. or antibiotic administration.[37] Mortality/Morbidity Congenital factor II deficiency is a lifelong bleeding disorder. Because prothrombin is synthesized almost exclusively in the liver. Hemorrhage can also occur as a result of surgery if precautions are not taken.[32] Vitamin K deficiency can be iatrogenically induced by the administration of propylthiouracil or vitamin K antagonists such as warfarin. have also been described.
FRCPC Professor. MB. American Society of Hematology. University of Nebraska Medical Center College of Pharmacy. MD is a member of the following medical societies: American Association for Cancer Education. University of Barcelona Faculty of Medicine. New York Academy of Sciences. Editor-in-Chief. DO. Department of Internal Medicine. Talecris Honoraria Board membership Rebecca J Schmidt. University of Cincinnati Academic Health Center Ronald A Sacher. American Association of Blood Banks. Department of Internal Medicine. MD Emeritus Professor. PhD Professor and Director. Jefferson Medical College of Thomas Jefferson University Emmanuel C Besa. Hoxworth Blood Center. American Society of Hematology. Department of Medicine. and New York Academy of Sciences Disclosure: Nothing to disclose. PharmD. MD.medscape. National Kidney Foundation. New York Academy of Medicine. PhD is a member of the following medical societies: Alpha Omega Alpha. FASN is a member of the following medical societies: American College of Physicians. and Royal College of Physicians and Surgeons of Canada Disclosure: Glaxo Smith Kline Honoraria Speaking and teaching. American Society of Clinical Oncology. College of American Pathologists. BCh. Renal Physicians Association. Francisco Talavera. Kimmel Cancer Center. FRCPC is a member of the following medical societies: American Association for the Advancement of Science. Private Practice Christopher J Steen. American College of Physicians. International Society on Thrombosis and Haemostasis. FACP. Medscape Drug Reference Disclosure: Medscape Salary Employment Ronald A Sacher. MD. Spain Pere Gascon. American Society of Nephrology. FACP. Drexel University College of Medicine. MD is a member of the following medical societies: Alpha Omega Alpha and Sigma Xi Disclosure: Nothing to disclose. American Federation for Medical Research.com/article/209742-overview Christopher J Steen. Adjunct Professor of Medicine. and New York Academy of Sciences Disclosure: Nothing to disclose. American Society of Hematology. MB. West Virginia University School of Medicine Rebecca J Schmidt. American College of Clinical Pharmacology. and West Virginia State Medical Association Disclosure: Renal Ventures Ownership interest Other Chief Editor Emmanuel C Besa. Pere Gascon. Internal Medicine and Pathology. BCh. Section of Nephrology. DO. FASN Professor of Medicine. Department of Medicine. Division of Hematologic Malignancies and Hematopoietic Stem Cell Transplantation. Institute of Hematology and Medical Oncology. MD. Specialty Editor Board Paul Schick. IDIBAPS. American Heart Association. MD is a member of the following medical societies: American College of Physicians. PhD Adjunct Assistant Professor. Lankenau Hospital Paul Schick. References 4 dari 7 3/16/2013 6:14 AM . American Medical Association. American Society for Clinical Pathology. International Society on Thrombosis and Haemostasis. International Society of Nephrology. MD. American Clinical and Climatological Association. Jefferson Medical College of Thomas Jefferson University. MD Professor. Section Chief. Research Professor. Director. Division of Medical Oncology.Factor II http://emedicine. and Sigma Xi Disclosure: Nothing to disclose. MD Dermatologist. International Society of Blood Transfusion.
4. Asero R. Kemahli S. Coleman MJ. Hsieh K. and the risk of venous thrombosis.20(8):627-34. et al. 1972. Atasay B. 15. 3. Feb 2010. Prevalence of factor V Leiden and prothrombin G20210A gene mutation. Silvello L. Lalouschek W. Matched case-control study on factor V Leiden and the prothrombin G20210A mutation in patients with ischemic stroke/transient ischemic attack up to the age of 60 years. 5 dari 7 3/16/2013 6:14 AM . Sun WY.26(4):580-3. Margaglione M. [Medline]. Feb 9 2005. Doggen CJ. Arsan S. [Medline]. Osanto S.36(7):1405-9. 6. 13. Prothrombin deficiency results in embryonic and neonatal lethality in mice. J Dermatol . Marzano AV. Bajaj SP. 14. Colbert MC. et al. Cugno M. Apr 2010. Poort SR.13(3):285-92. [Full Text]. Schillinger M. Jul 1 2002. [Medline]. [Medline]. Rapaport SI. Rosendaal FR. Brancaccio V. Geographic distribution of the 20210 G to A prothrombin variant.79(4):706-8. [Medline]. Hereditary hypoprothrombinaemia. Stroke. Witte DP. Royle NJ. Rosendaal FR. [Full Text]. Sun WY. [Full Text]. Congenital deficiencies and abnormalities of prothrombin. Bertina RM. 1992. Spaargaren-van Riel CC.Factor II http://emedicine. Russell JE. [Medline]. [Full Text]. JAMA. [Medline]. Vos HL. Dec 2003. 11. Herbst KD. Irwin DM. Holburn RR. Activation of blood coagulation in chronic urticaria: pathophysiological and clinical implications. 8. Bertina RM.65(6):1538-43. Ceelie H. respectively. Pediatr Hematol Oncol . Apr 1998. Proc Natl Acad Sci U S A. MacGillivray RT. May 1987. Baudo F.88(10):3698-703. Degen JL. 18. Tedeschi A. Reitsma PH. [Medline]. [Medline]. 12.ii:379-82. 2. Zivelin A. [Medline]. Sucakli IA. [Medline]. Lam HS. et al. 19. Increased risk for venous thrombosis in carriers of the prothrombin G-->A20210 gene variant.com/article/209742-overview 1. A common genetic variation in the 3'-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis. Dec 2002. [Medline]. Pollak ES. Congenital dysprothrombinemia: an inherited structural disorder of human prothrombin. [Full Text]. 10. Akar N. 1947. Girolami A. Koschinsky ML. Jan 2004. effect on protein levels and 3'-end formation.129(2):89-93. Human genes encoding prothrombin and ceruloplasmin map to 11p11-q12 and 3q21-24. Holmbäck K.5(2):97-101. G20210A is a functional mutation in the prothrombin gene.293(6):715-22. True deficiency of factor II. [Medline]. de Cataldo F. 20. Saggiorato G. Jul 15 1998.48(12):2251-9. Scarano L. J Clin Invest. [Medline]. Josso F. [Full Text]. [Medline]. Oct 1998. Somat Cell Mol Genet. Lancet. Devecioglu C. [Full Text]. prothrombotic mutations. New algorithm (KAWAKAMI algorithm) to diagnose primary cutaneous vasculitis. Doggen CJ. Intern Emerg Med. Saudi Med J . Acta Haematol . Malignancies. Thromb Haemost. Blom JW. Blood. Rosendaal FR. Blood. [Medline]. Batun S. Blood. 9. 17. Nov 15 1996. Hamerton JL. Degen SJ. Ann Intern Med. 7. Factor V Leiden and prothrombin gene 20210A variant in neonatal thromboembolism and in healthy neonates and adults: a study in a single center. Martinez J.47(4):243-9. Kawakami T.medscape. et al.2(1):119-27. Giuliani N.100(1):359-62.37(2):113-24.95(13):7597-602. Jul 2005. Shapiro SS. Degen SJ. Rescue of prothrombin-deficiency by transgene expression in mice. [Medline].88(6):984-91. Semin Thromb Hemost. Jun 23 1998. et al. Burkart MC. 16. Barclay S. Apr 2005. Jun 1985. Witte DP. Congenital hypoprothrombinemia and pseudo-hypoprothrombinemia. Soker M. Thromb Haemost. Dec 1969.18(2):230-42. [Medline]. Quick AJ. Blood Coagul Fibrinolysis. J Thromb Haemost. Irdem A. [Medline]. [Full Text]. Acquired hypoprothrombinemia due to non-neutralizing antibodies to prothrombin: mechanism and management.9(7):557-69. The G20210A mutation does not affect the stability of prothrombin mRNA in vivo. The prothrombin gene and its liver-specific expression. Gunlemez A. 5.
factor X. Yamazaki M. Oonami K. Gabazza EC. 28. Finazzi G. Takeya H. Fu Q. Sun WY. Molecular Basis of Thrombosis and Hemostasis . Jones KA. [Medline]. Vidaud D. [Full Text]. Vivaldi P. 29. [Medline]. [Medline]. Jul 2007. A second case of prothrombin Puerto Rico I in the United States. Akhavan S. Prothrombin.80(3):407-12. [Full Text]. Rouy S. [Medline]. [Medline]. Clin Rheumatol . Jun 1999. Burkart MC. Tabata N. 32. Dec 2000. [Full Text].107(2):197-205. Miyawaki Y. Viswabandya A. J Thromb Haemost.57(2):279-87. factor VII. Dec 2007.105(3):670-2. [Medline]. Sep 1998.90(3):313-4. Prothrombin Saint-Denis: a natural variant with a point mutation resulting in Asp to Glu substitution at position 552 in prothrombin. Mannucci PM. In: High K. Jan 2003. Ann Clin Lab Sci . Alessandri JL.3(7):1446-53. 38. Apr 2001. J Thromb Haemost. Multifunctional roles of thrombin. Severe bleeding due to acquired hypoprothrombinemia-lupus anticoagulant syndrome. 37. Mannucci PM. Zhou R. Huntsman DG. [Medline]. et al. Identification and three-dimensional structural analysis of nine novel mutations in patients with prothrombin deficiency.29(4):275-80. A study of Vitamin K status in children on prolonged antibiotic therapy. Cote HC. links prothrombin deficiencies in the Puerto Rican population. Prothrombin carora: hypoprothrombinaemia caused by substitution of Tyr-44 by Cys. Pezzetti L. Weller A. A common mutation.84(6):989-97. Bhat RV. Haematologica. Br J Haematol . Lechler E.132(6):770-3. Deshmukh CT. Lepore L.82(7):661-2. Nuss R. Case report and review of literature. Indian Pediatr.85(4):651-4. [Medline]. Bosch N. Haemophilia. et al.40(1):36-40. 35. Zhou H. Narayanan S. Mar 2006. Baidya S. Thromb Haemost. Degen SJ. Luciani M. [Medline]. 26. Br J Haematol . Kling SJ. 40. Am J Hematol . New York. Prothrombin-antibody coexistent with lupus anticoagulant (LA): clinical study and immunochemical characterization. Am J Clin Pathol .95(4 suppl 1):S39-50. Thromb Res. A new method for characterization and epitope determination of a lupus anticoagulant-associated neutralizing antiprothrombin antibody. 30. Thromb Res . Arg457-->Gln. et al. Taddio A. Nov 2003. [Medline]. Thromb Haemost. Oct-Dec 1999. 1995:75. 24. [Medline].com/article/209742-overview 21. [Medline]. Lefkowitz JB. Jun 21 2012. Lavoretano S. Roberts H. Wu J. [Medline]. 23. or protein Z. et al. Wang W. Degen S. Baudo F. Prothrombin and its derivatives stimulate motility of melanoma cells. et al.82(3):345-7. Feb 1997.26(12):2167-9. Brescia AC. [Medline]. NY: Marcel Dekker. Rose CD. May 2010. eds. 33. Jan 2004. [Medline]. et al. Jayandharan G. Aug 15 1999. [Medline]. Jenkins ML. N Engl J Med. Suzuki A. Lak M. May-Jun 1997.medscape. Use of prothrombin complex concentrates for prophylaxis and treatment of bleeding episodes in patients with hereditary deficiency of prothrombin. Rodgers GM. 34.10(1):94-7. Steady improvement of prothrombin levels after cyclophosphamide therapy in pediatric lupus anticoagulant hypoprothrombinemia syndrome (LAHPS).1(11):2381-8. MacGillivray RT. et al. Redaelli R. Prothrombin Scranton: substitution of an amino acid residue involved in the binding of Na+ (LYS-556 to THR) leads to dysprothrombinemia. Livedo vasculopathy associated with IgM anti-phosphatidylserine-prothrombin complex antibody. et al. Rossetti G. Thrombosis from a prothrombin mutation conveying antithrombin resistance. Phenotypic and genetic analysis of a compound 6 dari 7 3/16/2013 6:14 AM . 39. Ishibashi M. protein C protein S. [Medline]. Degen SJ. 25. [Medline]. Prothrombin Shanghai: hypoprothrombinaemia caused by substitution of Gla29 by Gly. Wadsworth LD. 31. Akhavan S. Sun WY. Ruiz-Saez A. 36. Smirnow D. [Full Text]. Acta Derm Venereol . 22.Factor II http://emedicine. Jan 15 1990.366(25):2390-6. Molecular genetics of hereditary prothrombin deficiency in Indian patients: identification of a novel Ala362 --> Thr (Prothrombin Vellore 1) mutation. Thromb Haemost. Fujita J. Jul 2005. Galli M. 27.
43. Jan 2003. Prothrombin Greenville. Sun WY. James AH. Kearon C. [Medline]. Poort SR.112(12):4432-6. Hirsh J. [Full Text]. 46. Thromb Haemost. Rossi E. et al.99(6):1030-4. 45.120(1):142-4. Dunham CK. Blood. Gabreels FJ. [Medline]. Jun 2008. Scarparo P. chromogenic and immunological assays in patients with congenital prothrombin deficiency. [Medline].htm. VII. et al. 2008.nih. Holahan JR. Accessed December 2. N Engl J Med. Jun 2008.30(6):320-4. [Full Text]. Obstet Gynecol . and X (Borgschulte-Grigsby deficiency) in pregnancy. Leone G. [Medline]. [Medline]. 'II' be or not 'II' be tested. Blood. Combined deficiency of factors II. Strijks E. Medline Plus Medical Encyclopedia. Girolami A. 41. McMahon MJ. Burkart MC. National Hemophilia Foundation. author reply 518-9. Julian JA.Factor II http://emedicine. Henriksen RA. HEMEX Laboratories.83(6):518.91(6):2026-31. 50. [Full Text]. De Stefano V. Blood. Allemand E.340(12):901-7.a new thrombophilia risk. Accessed December 2. Dec 1 2008. Mar 15 1998. [Medline].hemophilia. Neuropediatrics . IX. Degen SJ. [Full Text]. Hereditary prothrombin deficiency presenting as intracranial haematoma in infancy. 47. Kovacs MJ. 48. Updated January 23.com/article/209742-overview heterozygote for dys. Available at http://www. The risk of symptomatic pulmonary embolism due to proximal deep venous thrombosis differs in patients with different types of inherited thrombophilia. Medscape Reference © 2011 WebMD. 51.97(5 pt 2):808-9.nlm.htm. Am J Hematol . A comparison of three months of anticoagulation with extended anticoagulation for a first episode of idiopathic venous thromboembolism.org/bdi/bdi_types5. May 2001. Mutations are no substitutes for clotting. 49. Br J Haematol . LLC 7 dari 7 3/16/2013 6:14 AM . Learn about coagulation disorders: factor II deficiency. et al. Bertina RM. Updated March 13. 44. identified in an individual heterozygous for dysprothrombinemia. 2008. Za T. Accessed December 2. Prothrombin San Antonio: a single amino acid substitution at a factor Xa activation site (Arg320 to His) results in dysprothrombinemia. [Medline]. Kearon C.95(2):711-4. Gent M.and hypoprothrombinaemia.medscape. 2008. [Medline]. Jan 15 2000. Arg517-->Gln. 42. Miller LD. Prothrombin gene mutation . 2007. Influence of thrombophilia on risk of recurrent venous thromboembolism while on warfarin: results from a randomized trial. Factor II deficiency. Renier WO. Ciminello A. Available at http://www. [Medline]. Mar 25 1999. 2003. Dec 1999.gov/medlineplus/ency/article/000549.
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So this is what happens when I don't do my hair – I become carefree and climb a tree to relax and be at one with nature. Or maybe I'm just trying not to fall out of a tree and regret ...Read More »
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Red HousesWhat has God given you—time, finances, ability—that you can use to help someone in need today?
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BYU beats Southern Miss to storm into NIT final four, 79-62
BYU is headed to New York to play in the NIT semifinals after beating No. 1 seed Southern Miss, 79-62 Wednesday night.
Impressive shooting helped the Cougars achieve the road victory, led by Tyler Haws with the game high 25 points, and two players with double-doubles. Brock Zylstra had 23 points and 10 rebounds, and Brandon Davies had 12 points and 11 rebounds.
The Cougars also had 24 assists in the game, led by Matt Carlino with nine. BYU was shooting well from all over the court, and made 11 three-pointers on the night.
The Cougars will now go on to face either Baylor or Providence in the Final Four.
Read on for some of the social media highlights from Cougar fans as BYU stormed to victory.
BYU basketball: Cougars cruise past Southern Miss, advance to NIT Final Four in New York
Zylstra leads Cougars to NIT semifinals
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J. Scott Applewhite, Associated Press
WASHINGTON — In a capital city on edge, letters sent to President Barack Obama and a Mississippi senator tested positive for poisonous ricin in preliminary checks, and authorities chased a stream of false alarms about seemingly suspicious packages and mail sent to senators in Washington and beyond.
Authorities still waited for definitive tests on the letters to Obama and Sen. Roger Wicker, R-Miss., which had raised concern Wednesday at a time when many people were jittery after the Boston bombings.
An FBI intelligence bulletin obtained by The Associated Press said those two letters were postmarked Memphis, Tenn. Both letters said: "To see a wrong and not expose it, is to become a silent partner to its continuance." Both were signed, "I am KC and I approve this message."
The letters were intercepted before reaching the White House or Senate. The FBI said Wednesday that more testing was underway. Preliminary field tests can often show false positives for ricin.
As authorities scurried to investigate three questionable packages discovered in Senate office buildings, reports of suspicious items also came in from at least three senators' offices in their home states.
Sen. Carl Levin said a staff member at his Saginaw, Mich., office would spend the night in a hospital as a precaution after discovering a suspicious letter. The staff member had no symptoms, Levin said in a statement. He expected to learn preliminary results of tests on the letter by Thursday.
Sen. Jeff Flake, R-Ariz., said suspicious letters at his Phoenix office had been cleared with nothing dangerous found. A package at Sen. John Cornyn's Dallas-area office also was declared harmless, a fire department spokesman said.
All three packages in the Capitol complex turned out to be safe, Capitol police spokeswoman Makema Turner said late Wednesday. But a man was still being questioned after being stopped in connection with the packages, she said.
All the activity came as tensions were high in Washington and across the country following Monday's bombings at the Boston Marathon that killed three people and injured more than 170. The FBI said there was no indication of a connection between the letters and the bombing. The letters to Obama and Wicker were postmarked April 8, before the marathon.
Capitol Police swiftly ramped up security, and lawmakers and staff were cautioned away from some parts of the Hill complex. After hours of jangled nerves, officials signaled it was safe to move throughout the area and people settled back to normal, if watchful, activity.
Sen. Claire McCaskill, D-Mo., said that police had a suspect in mind in the Wicker mailing, someone who "writes a lot of letters to members." She made the comment Tuesday as she emerged from a briefing by law enforcement on the Boston bombing. Authorities declined to comment on a possible suspect.
Obama's press secretary, Jay Carney, said mail sent to the White House is screened at a remote site for the safety of the recipients and the general public. He declined to comment on the significance of the preliminary ricin result, referring questions to the FBI.
At a House hearing, Postmaster General Patrick Donahoe noted there had been ricin alerts since the notorious 2001 anthrax mailings and procedures are in place to protect postal employees and help track down culprits.
"Over the course of years we've had some situations where there have been ricin scares," Donahoe said. "Until this date, there's never been any actually proved that have gone through the system."
After the hearing, Donahoe said he didn't know whether the latest letters had been proven to contain ricin. He also told reporters that people sometimes mail substances that mimic the poison. No postal workers have reported illness connected to the incident, he said. Ricin, derived from the castor plant, is at its deadliest when inhaled.
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Vice President Dick Cheney said Tuesday morning he would personally meet with Palestinian Authority Chairman Yasir Arafat in the event of a cease-fire between Israelis and Palestinians.
Cheney, who had just completed a 10-nation visit to the Middle East, said the U.S. would remain ?very actively engaged? in talks between Israelis and Palestinians brokered by American envoy Anthony Zinni." />
A Jewish organization creates unforgettable summer experiences for special needs kids and their parents.
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Manpower is seeking TOP talent for a client in the Manassas and Woodbridge area with a background in event planning, psychology, community health or recreational planning. As a part-time Activities Coordinator you will aid and plan events and activities for senior adults. As the ideal candidate you are self-driven, are confident in your computer skills and care about others. You will aid two locat...
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I See The Moon
Por BEST BRANDING APPS LLC
Abre iTunes para comprar y descargar Apps.
Having trouble remembering the words to I See The Moon? Not to worry. This lullaby player includes the lyrics so you can sing along.
Young children love repetition. How often do we hear "Play it again! Play it again!" So this player features a repeat function that plays this lullaby up to 12 times in a row. And, if that's not enough, there's also has a loop feature that plays the song over and over until you press stop.
The controls are so easy to use that a 2 year old will quickly learn to use this app themselves and it will help them learn to count, too.
The music is gorgeous. Listen for yourself by clicking on the YouTube video below. It is performed by leading lullaby singer and healing music artist, Amy Robbins-Wilson. She holds a masters degree in song performance from the University of Limerick in Ireland and her clear and crystalline voice has been called "angelic" and "like a whisper to the soul". She's a Mom's Choice Awards gold medalist and this recording has been recognized with a Kid's Music Award.
The MP3 alone sells on iTunes for 99 cents so this app is like getting a baby friendly music player for free! And if your little one melts down in public or at home, this app works wonders as a tantrum tamer by refocusing your child with some truly beautiful and calming music.
Buy now and start enjoying this glorious music with your child today.
Capturas de pantalla del iPhone
- Categoría: Entretenimiento
- Publicado: 23/03/2012
- Versión: 1.0
- Tamaño: 9.3 MB
- Idioma: Inglés
- Vendedor: BEST BRANDING APPS LLC
- © 2012 Angelsong Creations LLC
Compatibilidad: Requiere iOS 4.3 o posterior. Compatible con iPhone, iPad y iPod touch.


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Mass Effect PC Review
[img]masseffect_pc_3[/img]Squad control is a big factor in Mass Effect's combat system and can easily be the overriding factor in whether you succeed or die during a mission. Throughout the storyline you will be given the opportunity to pickup a few allies from most of the prominent species, where naturally each have their own special abilities to offer. At any given time however only two squad members can be with you, so choosing the best ones to take before a mission is a strategy in itself. There is plenty of real
time squad strategy to be had too however, including the ability to order movements, all the way up to dictating which gun a member has drawn, who to attack, and even orders to use specific special abilities on specific enemies. This is done via the game's 'Tactics HUD', which you access by holding down 'Space', and while it takes a little getting used to, it is a powerful tool during combat, albeit one you may grow to ignore after a while as your character becomes capable enough to take on most foes alone.
The third and final major element to the gameplay is one you will encounter a little later on into the game, and that's space travel. Without spoiling too much, a little while into the storyline your character will gain captainship of a space craft, which you can navigate to star systems and planets of your choosing. Of course not [img]masseffect_pc_4[/img]all planets are habitable so you can't land just anywhere, but there are quite a few planets to explore, and not always as the storyline demands either. While the storyline will
usually require you to go to a particular system or planet, you're free to do this at your own pace most of the time, so you could go and explore elsewhere if desired. Besides, the vast majority of the time the game features a mission system with multiple on-going missions that can be tackled in any order, not to mention a fair few secondary missions you can pickup during conversations, so you're generally free to do as you wish most of the time. While space travel in Mass Effect is nothing more
than a navigation system with no real control involved, when you land on a planet without a docking station you will be launched down inside a buggy with gun and missile capabilities, so there is some degree of vehicle control.
With these three elements to gameplay, Mass Effect encompasses a large scope of variation and their seamless integration with one another makes for a reasonably fresh gaming experience from start to finish. After a while a few patterns will emerge and repetition may start to settle in slightly, but the strong storyline really keeps you going as you're always eager to see what's around the corner next. As well as this, like any good RPG, Mass Effect also keeps you hooked with its character
development system, which can be quite rewarding. One thing we found though was even if you focus on as many secondary missions as possible, chances are you won't max out your character before finishing the storyline however you can always start from the beginning again with a character you have already built up, which is a nice touch as you could play the storyline again with a different approach (for example, as a bad guy and not a nice guy) and manage to experience some new events and outcomes you
may not have seen the first time around. In general though, the game could stand to add a few more hours to the play time, but I guess they had to leave some stuff for the next two titles in the planned trilogy.
As far as the PC version goes, not a whole lot has changed since the Xbox 360 release. There have been a few GUI changes here and there, plus the controls and graphics have been enhanced with hot keys and higher resolution textures respectively, but the game is basically identical really. This is not a bad thing though as the folks at BioWare have ample experience in this genre, mostly on the PC, and this comes through with Mass Effect PC. I wouldn't say it feels exactly like it was built for the PC
platform, but as far as console ports go, it's definitely not blatantly obvious. The controls are very PC friendly, adopting a 'WASD' system every PC gamer will pick up on instantly, and the presence of stuff like quick saves and a detailed graphical options menu show that BioWare has put some effort into making this RPG feel at home on the PC. So much so, it seems you have to use the keyboard and mouse combination, as I couldn't get my USB 360 controller to work with Mass Effect at all.
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Hurricanes (by whatever name) are by far most common in the Pacific Ocean, with the western Pacific being most active. In some years, the Philippines are struck by more than 20 tropical storms and typhoons. The term applied to various storms depends on their location. Only one hurricane force storm has ever occurred in the South Atlantic - Hurricane "Catarina" in 2004.
Below is a map showing where each tropical cyclone has tracked between 1851 and 2007... use our Interactive Tracker to plot the storms on top of road and aerial maps.
When hurricanes strike is also determined by location. Below is a brief description of each basin's "hurricane season." More information can be obtained from the NOAA Hurricane FAQ.
ATLANTIC: Hurricane season in the Atlantic runs from June 1 to November 30. Storms outside of these dates are not unheard of. As you can see from the graph, based on the average of 150 years of storms, activity ramps up in August, and peaks once in early September, then again in October. More statistics are available here. Persons traveling to areas near the Atlantic Basin should exercise caution during the entire Hurricane Season.
EASTERN PACIFIC: The Eastern Pacific basin's hurricane season is from May 15th to November 30th, peaking in late August or early September.
WESTERN PACIFIC: The Western Pacific basin's hurricane season is mostly from July 1 to November 30, peaking in late August or early September, though storms can occur year-round.
SOUTH PACIFIC: The South Pacific basin's hurricane season is from October 15 to May 15, reaching a peak in late February or early March.
INDIAN OCEAN: The Indian basin's hurricane season is from April 1 to December 31 for the northern Indian Ocean, and from October 15 to May 31 in the southern region.
Weather plays a bigger role than you may think when it comes to seasonal outdoor allergies.
Why can different types of precipitation be seen on Earth while temperatures remain constant?
Dangerous flash flooding is captured as an arroyo becomes filled with water in Carson Valley, Nevada.
The RealFeel Temperature uses an equation to determine how it actually feels outside.
Knowing what the different advisories, watches, and warnings mean will lead to more informed decision making when a winter storm threatens a particular area.
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Seeking shelter in the event of a tornado could save your life, but is there really any safe place to hide?
Driving on a 90-degree angle away from the tornado is a good strategy to follow in order to distance yourself from the tornado.
Supercell thunderstorms have been responsible for major tornadoes that have demolished parts of the U.S.
After a cold, clear winter night without much wind, the ground and nearby tree branches may be covered by tiny, white ice crystals.
Tucson, AZ (1952)
60-mph winds ripped roofs off an apartment complex and an airplane hangar, sweeping dust and sand through the city and leaving 200 persons homeless.
North Carolina (1975)
Lightning killed 13 cows during a thunderstorm at Kenansville. Heavy rains elsewhere in the state forced the Tar River out of its banks at Greenville, causing 14 families to evacuate their homes.
New York (1975)
Severe thunderstorms in western and central NY: lightning struck a city park in Rochester injuring 12 children, all were playing on a metal jungle gym. One patrolman described the scene as if "someone threw a stick of dynamite in the middle of the crowd and it blew."


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ADA Info
June 6- August 6
Grab your sari and bangles, too. Let's all head to Bombay.
We're going to take a vacation and have a South Asian Soiree!
Bring your imagination and join our celebration of Asian Pacific American Heritage Month with an interactive program by Arts Alive!
Date: Monday, May 23
Time: 6:30 - 7:30 p.m.
Recommended for ages 4-11
Space is limited.
Copyright © 2016 Vital Imagery Ltd.
Wash your hands and come ready to measure, pour and taste! We are making pineapple upside-down cake!
Date: Wednesday, May 11
Time: 4:00-5:00 p.m.
Ages: 5-11
Space is limited.
In May, we'll be offering the following computer classes:
How to Use Facebook—May 5
Mobile Devices One-on-One—May 12 (bring your own device)
Google Docs—May 19
Computer Basics—May 26
All sessions are scheduled for Thursdays from 3:30 pm to 5:00 pm.
Sign up at the Information Desk or call 713-464-1633.
We had to cancel our ESL classes on Fridays at 4:30-5:30.
We apologize for any inconvenience.
Title to be discussed: The boys in the boat by Daniel James Brown. Date of meeting: Tuesday, May 10, 6:30 p.m. Summary: "The University of Washington's 1936 eight-oar crew transformed the sport and grabbed the attention of millions of Americans. The sons of loggers, shipyard workers, and farmers, the nine boys, in the depths of the Great Depression, showed the world what beating the odds really meant. They defeated elite rivals from California and eastern schools to earn the right to compete against the German crew rowing for Adolf Hitler in the Olympic games in Berlin. The crew was assembled by an enigmatic coach and mentored by a visionary, eccentric British boat builder, but it was their trust in each other that made them a victorious team."
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Oak Park, ILUSA
February 16, 2012
No answer yet
Open Source @ JBoss.
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My daughter's doctor gave us the number to Abrazo because we didn't know what to do. She was not ready to be a mom but a baby was on the way. We called after hours and got the nicest lady, a counselor who answered all our questions and even offered to come meet with us right away. She was easy to talk to, and put my daughter and me right at ease. When we went to their offices, we were so impressed. It was beautiful. The whole staff was extremely professional, caring and approachable. They went out of their way to meet my daughter's needs, and expressed concern for me as well. Through Abrazo we found the most wonderful adoptive family, and they too had nothing but good things to say about this agency. Abrazo Adoptions does an excellent job of educating its clients about open adoption and why it's important for kids who are adopted, and as a result, my grandson's family has kept in touch and we see them each year at Camp Abrazo, the agency's summer reunion. They offer ongoing counseling for their birthparents, and also have a Forum on their website where anyone whose been impacted by adoption can find support. I've heard plenty of bad reports about other adoption agencies in San Antonio, but we are very proud to be part of the Abrazo community, and we are very glad we found them.
San Antonio Architectural Division 8
1. Architectural Division 8
2425 Brockton St Ste 103San Antonio, TX 78217
2. Pella Windows & Doors
6510 Blanco RdSan Antonio, TX 78216
From Business: At Pella San Antonio, our team is passionate about three things: windows, doors, and helping you choose the best products for your window or door replacement projec…
3. Champion of San Antonio
6021 Randolph Blvd.San Antonio, TX 78233
From Business: Champion is the leading manufacturer and installer of energy efficient, maintenance free, custom replacement windows, patio rooms, entry doors and vinyl siding. We …
4. Pop-A-Lock
just wanted to say thank you for your prompt service and friendly attitude. it only took about 5 minutes from the time i called and my beautiful dau…
5. Cavallini Co., Inc. Stained Glass Supply Center
303 Vance Jackson RdSan Antonio, TX 78201
From Business: Custom stained glass, mosaic, etched, beveled, leaded doors, windows, cabinets, pantry doors, panels. Wholesale on Kokomo, Wissmach, Bullseye glass, solder, copper …
6. Champion Windows Sunrooms Roofs & Home Exteriors
From Business: Many companies claim that they are factory direct, but Champion actually has its own factories! We handle your home improvement investment from design to warranty, …
7. Pella Windows and Doors
From Business: At Pella South Texas, our team is passionate about three things: windows, doors, and helping you choose the best products for your window or door replacement projec…
8. Academy Window Coverings Co
I have been working with Mrs. Valadez for more than three years now and the service I receive is unparalleled. Academy's selection of blinds and shu…
9. Freedom Builders Enterprises Inc
6345 Bowman RdgSan Antonio, TX 78249
10. ACI Supply Company
Serving the San Antonio Area.
From Business: We have everything you need for your security storm doors hardware replacement parts needs, including hard to find parts or replacements for older doors. We carry r…
11. ACI Supply
Serving the San Antonio Area.
From Business: Patio security doors open from one side only. Available in sizes (72" 70" 60" x 80") with hinges on the left or right. These doors also come with the EZ-Set deadbol…
12. ACI Supply Co.
Serving the San Antonio Area.
From Business: (Please Note) We ship nationwide. All doors are fully assembled in our warehouse ready to ship in 24 hrs. They are packed in our 'one of a kind' special built crate…
13. Handyman Matters San Antonio
314 E Nakoma St Suite TSan Antonio, TX 78216
From Business: Keeping your home in good repair and maintaining the property after you purchase a house is not always as easy as it sounds. It can sometimes become a complicated p…
14. Pro-Tech Automatic Gates & Fencing
210 Bluebonnet LnSan Antonio, TX 78223
15. Architectural Antiques Salvage & Stripping
Thousands of beautiful antiques to look at!!! I'm sorry for the other review that was wrote. It made me a little leery to go into their business. …
16. Guadalupe Lumber Co
I came here for a special piece of molding for a shelf project. The guy that helped me in the molding section was very friendly and helpful. T…
17. ABC 1 Remodeling & Repairs
1039 Rigsby AveSan Antonio, TX 78210
From Business: Bathroom Remodeling, Kitchen Remodeling, Door Repair, Interior & Exterior Painting, Carpentry, Room Additions, Flooring, Custom Remodeling, Roofing, Fences, Texturi…
18. R & H's Mobile Home Parts
I have bought many items from R & H and havent been disapointed yet every time I need to buy something for the two mobile home's that i own …
19. Solar Shades
We are very pleased with the results. Our heat ploblem just seemed to go away, and we'll see some great savings on our electric bill too. Mike
20. South Texas Windows and More
Serving the San Antonio Area.
21. Door Repair & Installation Pros
Serving the San Antonio Area.
From Business: Home Improvement Door Experts will provide you with fast, easy, and affordable quotes on your next home project. You can request quotes and set up scheduling either…
22. Mair's Manufactured Home Supply
14507 Donop Rd @ Ih 37 SouthElmendorf, TX 78112
From Business: Mair's Manufactured Home Supply has one of the largest inventories in South Central Texas.
23. Reliable Door Pros
The doorframe was slightly off becuase the house was so old. But thankfully the contractors were able to repair the damage and fix it up right.
24. A To Z Construction & Remodeling
Serving the San Antonio Area.
From Business: Full Service General Commercial and Industrial, Doors & Door Closers, Handyman Services, Porperty Maintaince & Repair
25. Colonial Iron Doors - CLOSED
8666 Huebner Rd Ste 106San Antonio, TX 78240
26. Overhead Door Co Of Sn Antonio
385 N Weidner RdSan Antonio, TX 78233
27. Precision Overhead Door of San Antonio
Quality of work is not what it should be.
28. Doors & Key's
1710 Austin HwySan Antonio, TX 78218
29. Blue Bonnet Exteriors
818 West AveSan Antonio, TX 78201
30. Door Control Services
12200 Crownpoint DrSan Antonio, TX 78233
Michael worked from photographs sent via email and drawings to create a timeless piece of art to compliment the custom cabinetry in our hill country home. His genius is in design form and color. He literally recreated the vista from our front porch and seamlessly incorporated the mural of stained glass in a continuous pattern on four doors. The effect is stunning, yet not over the top. Michael is professional, meticulous, and a uniquely talented artist. He is attentive to the precision during installation and masterful with unexpected detail. Great work, nice guy!
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July 2016
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Exclusive News
Jerry C. Alexander has been sworn in as the 107th President of the Dallas Bar Association
By Passman & Jones, A Professional Corporation
Passman & Jones Shareholder and President Jerry C. Alexander has been sworn in as the 107th President of the Dallas Bar Association
John G. Browning is the recipient of the 2016 Lola Wright Foundation Award
By Passman & Jones, A Professional Corporation
Passman & Jones Shareholder John G. Browning is the recipient of the 2016 Lola Wright Foundation Award, presented annually to a Texas attorney "in recognition for outstanding public service in advancing and enhancing legal ethics in Texas.
Coats + Bennett Attorney, John Owen, Elected to Business NC 2016 Legal Elite
By Coats + Bennett, PLLC
Coats + Bennett, PLLC, an intellectual property law firm located in Cary, North Carolina, has announced that John Owen has been elected to the 2016 Legal Elite by Business North Carolina magazine. Mr.
Attorney Patterson Now Board Certified in Civil Trial Law by the Texas Board of Legal Specialization
By Patterson, P.C.
Attorney Pete Patterson of Patterson, P.C. in Houston, Texas receives certification in Civil Trial Law from the Texas Board of Legal Specialization, adding to his certification in Personal Injury and Civil Trial Law.
William La Forte to Speak at Continuing Lawyer Education Seminar
By Trevett Cristo Salzer & Andolina P.C.
Rochester-based Attorney Plans to Speak at Continuing Lawyer Education Seminar
Burdett, Morgan, Williamson & Boykin, LLP Announces New Board Certification for Attorney
By Burdett, Morgan, Williamson, & Boykin, LLP
Beau A. Cross is now Board Certified in Estate Planning and Probate
Joseph F. Diaco Jr. Law Launches Site
By Diaco Law
Joseph F. Diaco, Jr., Esq. of Diaco Law announced on Monday that his firm has launched a new website, www.diacolaw.com, marking his attempt to introduce a site that is easy for potential personal injury clients to navigate.
POTUS Signs Bipartisan Budget Act of 2015 Affecting LLCs
By Janik Bohmer PLLC
LLC Attorneys Explain New Auditing Parameters for Partnerships and Limited Liability Corporations
Stange Law Firm, PC Moves Headquarters Office To Clayton, Missouri
By Stange Law Firm, PC
Stange Law Firm, PC moves their headquarters office to Clayton, Missouri on January 1, 2016 at 120 S. Central Avenue, Suite 450, Clayton, Missouri 63105.
Stange Law Firm, PC Opens New Firm in Kansas City, Missouri
By Stange Law Firm, PC
Stange Law Firm, PC opens a new office in the Kansas City Area in Lee's Summit, Missouri.
Evan Guthrie Law Firm Teaches About Lawyers At James Island Middle School In Charleston, SC
By Evan Guthrie Law Firm
Evan Guthrie, of Evan Guthrie Law Firm, located locally in Charleston, South Carolina helped James Island Middle School with his lecturing expertise.
Evan Guthrie Law Firm Volunteers To Help Teddy Bear Picnic In Charleston, SC
By Evan Guthrie Law Firm
Evan Guthrie, of Evan Guthrie Law Firm, located locally in Charleston, South Carolina gladly extends his hand at volunteering for the local community at an annual picnic event. On Sunday March 9th, 2014 Charleston held it's famous Teddy Bear Picnic.
Wes Pittman Comments on Motorcycle Accidents
By The Pittman Firm, P.A.
Over the course of my 30+ years representing injured people, I have encountered many families who have touched me. One such family comes to mind as the December anniversary of the accident that changed their lives approaches.
Donna Greenspan Solomon, Esq. Explains How Long Mediation Takes
By Donna Greenspan Solomon, Esq.
There are instances where a big trial is a necessary reality. However, there are times when alternative dispute resolution (ADR) can save you time and money.
Donna Greenspan Solomon, Esq. Explains Alternative Dispute Resolution
By Donna Greenspan Solomon, Esq.
There is no doubt that alternative dispute resolution (ADR) can have its place in the legal community. Taking your issue to mediation or arbitration can allow you to settle a problem in a more amiable fashion.
Lake Geneva Attorney Receives Distinguished Service Award from Walworth County Bar Association
By Wynn at Law, LLC
Attorney Shannon Wynn, Principle at Wynn at Law, LLC, a law firm headquartered in Lake Geneva, Wisconsin received the "Distinguished Service Award" from the Walworth County Bar Association.
Legal Learning Series Proudly Announces Legal Computer Consultants as its Annual Sponsor for 2015
By Legal Learning Series
Legal Learning Series, a leader in legal education, networking and events, announced a new sponsorship from Legal Computer Consultants for its 2015 annual programming.
Kevin M. Bernstein Elected Chair Of Bond, Schoeneck & King Management Committee
By Bond Schoeneck & King PLLC
Bond, Schoeneck & King PLLC is pleased to announce that Kevin M. Bernstein has been elected to chair the firm's management committee.
Injured Cyclist Awarded Nearly $2 Million for Horrific City Dump Truck Crash
By Demas Law Group, P.C.
The local bike rider struck by a City of Sacramento garbage truck will receive $1.875 million in restitution for severe physical and emotional damages.
Employment Attorney in Key West has New Mobile Friendly Website
By Todd W. Shulby, P.A.
Employment attorney Todd W. Shulby, P.A. has created a new mobile friendly website to provide assistance for those seeking representation for labor law in Key West.
Attorney Michael Ehline accepted as a platinum-level lifetime member of Successful Verdicts
By Successful Verdicts
As of October 17th, 2015, attorney MIchael Ehline has been granted the honor of platinum-level lifetime membership into Successful Verdicts.
Bryce Johnson has been recognized as Top Lawyer of The Global Who's Who
By Johnson & Biscone, P.A.
Bryce B. Johnson, of Oklahoma City, Oklahoma has recently been invited to join The Global Who's Who for outstanding contributions and achievements in the field of Law.
California Workers' Compensation Injury Law Firm Online Offering Free Legal Consultations
By Calinjurylawyer.com
"Cal Injury law firm announces new service with free legal consultations for California working employees with possible job related work injuries or illnesses.
Oklahoma City University Law Grad James Joseph Biscone Joins Prominent Oklahoma City Law Firm
By Johnson & Biscone, P.A.
Johnson & Biscone, PA., welcomes James Joseph Biscone to its award winning team.
BQE Software Announces Strong Reception for BillQuick® Legal 2015
By BQE Software
Torrance, CA – BQE Software, Inc., a world leader in time billing, accounting and project management software, announced today unprecedented growth related to the release of BillQuick® Legal 2015.
Attention Investors: Beware of Non-Traded REITs
By Law Office of Howard Rosenfield
A recent study by SLCG concludes that non-traded REIT's [Real Estate Investment Trusts] should not have been sold to almost any investor.
Legal Learning Series Proudly Announces the Return of Ervin Gonazalez's Advanced Trial Bootcamp
By legal learning series
Legal Learning Series, a leader in legal education, networking and events, announced today that Ervin Gonzalez, of the firm Colson, Hicks and Eidson, along with Patrick Montoya, also from Colson, will return to present a two part seminar called Advanced..
Ciara J. Coleman Joins Berry Law Firm
By Berry Law Firm
Ciara Coleman has been hired to Berry Law Firm as an associate attorney for the firm's Lincoln office.
Jones Morrison Law Firm Welcomes Bohdan S. Ozaruk
By Jones Morrison, LLP
Bohdan S. Ozaruk joins Jones Morrison, LLP as an Of Counsel Attorney.
Jones Morrison Law Firm Welcomes New Senior Attorney Jeffrey Briem
By Jones Morrison, LLP
Jeffrey Briem joins Jones Morrison, LLP as a Senior Attorney.
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Arizona Diamondbacks
D-backs place outfielder Mark Trumbo on 15-day D.L.
The Arizona Diamondbacks placed left fielder Mark Trumbo on the 15-day disabled list Thursday and recalled outfielder Roger Kieschnick from Triple-A Reno.
An MRI revealed Trumbo has a stress fracture in the third metatarsal of his left foot. The imaging also revealed, according to Trumbo, some plantar fascia that he was already aware of.
In his first season with Arizona, Trumbo was tied for the National League lead with 7 home runs and was second with 19 RBI.
Kieschnick, 27, was hitting .281 (18-for-64) in Reno, with 3 home runs and 8 RBI. He was claimed off waivers from San Francisco in early April. Kieschnick, who will be in the lineup Thursday vs. the Cubs in the series finale, has a career Major League average of .202 (18-for-95).
He was originally a third-round pick of the Giants in 2008 out of Texas Tech.
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D-Backs Audio
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See who won the "Golden Arches" award, the "Legacy" award and more.
Bob Nightengale, USA Today MLB Insider
Monday July 25
Bob talks Chip Hale potential exit and Shelby Miller trade rumors.
Bickley Blast
Monday July 25
Rumors of Chip Hale's demise were greatly exaggerated
Steve Gilbert, MLB.com Diamondbacks writer
Monday July 25
Steve Gilbert says he can't imagine the Diamondbacks trading Shelby Miller.
Tim Kurkjian, ESPN MLB Insider
Friday July 22
Tim Kurkjian discusses the rumors that the Diamondbacks may fire manager Chip Hale.


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about us
GiveWell Community Foundation
Serving the Polk County Region & Beyond
In 1997, a group of residents who cared about shaping their city's future established the Community Foundation of Greater Lakeland (CFGL). Initially established as an affiliate of the Tampa Community Foundation, the CFGL became a stand-alone 501(c)3 public charity in 2000. Four years later, another group of community-minded citizens came together to establish an affiliate of the CFGL, the Community Foundation of Greater Winter Haven.
Through the years, the two organizations served neighboring geographic areas and accomplished great things. In 2013, the decision was made to combine their resources and form one community foundation that was capable of doing even greater work throughout the Polk County region. From this vision, the GiveWell Community Foundation was born and continues to be a reputable, efficient place to invest dollars that grow to do tremendous good. Learn More »
Latest News
Posted One week ago •
Join us for our Impact Polk Orientation August 12, 2016
Nonprofit organizations who do work in Polk County and are in good standing as described in Section §170(b)(1)(A) of the Internal Revenue Code are invited to apply for a grant from the GiveWell Community Foundation's Impact Polk Grant Program. The Impact Polk Grant Program addresses community needs and fosters civic leadership and engagement throughout Polk … Read On
Posted 1 month, 11 days ago •
Job Description: Communications Specialist
* Update 7/19 – We have hired someone for this role, and are excited to introduce this individual soon! The GiveWell Community Foundation is seeking a Communications Specialist. Candidates must have experience in working with social media platforms, websites, and possess a strong background and proficiency in writing. Familiarity with nonprofits and grantmaking services a plus. Salary … Read On
Community Events
2017 Impact Polk Orientation
The Impact Polk Grant Program addresses community needs and fosters civic leadership and engagement throughout Polk County.
UWCF Young Leaders Society Aprons Event
The Young Leaders Society (YLS) is a group of young adults who are trying to engage their contemporaries in philanthropy and volunteerism across Central Florida.
Featured Funds
CATT and Rath Center
The Coalition on Aging Transitions and Technology (CATT)-Rath Senior Connextions and Education Center's mission is to provide seniors with education, leadership, advocacy, resources and services enabling them to age with independence and dignity. Our fund helps us maintain Senior Scholar's, which is the educational program that promotes life-long learning with varied topics taught by experts.
YMCA of West Central Florida
At the YMCA strengthening community is our cause, through our focus on youth development, healthy living and social responsibility. We are able to provide programs such as a water safety, drowning prevention Learn to Swim program to Kindergarteners and an Adaptive Golf program, specifically designed golf instructional program, for individuals with physical and mental disabilities through … Read On
Learning Resource Center of Polk County, Inc.
The Learning Resource Center (LRC) Fund was established to offer others the opportunity to join LRC in its work and mission to address the academic needs of the community. Throughout its 40 years, LRC has touched thousands of children and adults, helping them to be more successful, and the fund will provide the sustainability to … Read On
Rotary Playground
The four Rotary Clubs of Lakeland (Lakeland Christina Rotary Club, Lakeland North Rotary Club, the Lakeland Rotary Club and the Rotary Club of Lakeland South) are working together to raise funds to build Rotary Playground in Hernando's Landing. This playground will be located within Lake Parker Park and will provide a nature-themed, interactive play experience … Read On
Hollis Garden
The Hollis Garden Maintenance Fund provides funds to maintain Hollis Garden, a Botanic Garden set in a neo-classical architectural environment complete with patterned flower beds, public art and ornamental fountains.


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Hotel Amic Gala, Mallorca Island
- Free WiFi in lobby
Main amenities
- 126 guestrooms
- Restaurant and bar/lounge
- Rooftop terrace
- Breakfast available
- Internet in the lobby
- Airport shuttle
- Childcare
- 24-hour front desk
- Air conditioning
- Arcade/game room
- Car rentals on site
- Front desk safe
For families
- Cribs/infant beds (surcharge)
- Playground on site
- Babysitting or childcare (surcharge)
- Rollaway/extra beds available
- Private bathroom
- Television
What's around
- In Can Pastilla
- Palma Aquarium (0.4 mi / 0.6 km)
- Cala Estancia (0.4 mi / 0.7 km)
- Hospital Sant Joan de Déu Palma de Mallorca (1.6 mi / 2.6 km)
- La Porciuncula Church (2.3 mi / 3.8 km)
- El Arenal Beach (2.9 mi / 4.7 km)
Hotel Amic Gala, Mallorca Island
Hotel Info: 866-539-8117from $112
- Superior Triple Room
- Superior Single Room
- Standard Single Room
- Standard Double Room
- Family Room
- Superior Double Room
- Standard Triple Room
Also popular with travelers from the USA
At a glance
Key facts
Hotel size
- This hotel has 126 rooms
- This hotel is arranged over 5 floors
- Check-in time starts at 1 PM
- Check-out time is 11 AM
- Express check-in/out
Required at check in
- Credit card or cash deposit required
- Government-issued photo ID required
Travelling with others
- Babysitting/childcare *
- Pets not allowed
Extra people
- Roll-away beds available, charges may apply*
- Free WiFi in public areas
- Airport shuttle (available on request) *
- No parking
- Discounted offsite parking
Other information
- No alcohol allowed onsite
Nearby Three Star Mallorca Island hotels
In the hotel
- Buffet breakfast (surcharge)
- Restaurant
- Bar/lounge
- Bicycle rentals on site
- Playground on site
- Golfing nearby
- Hiking/biking trails nearby
- Sailing nearby
- Water skiing nearby
- Windsurfing nearby
- Arcade/game room
- One meeting room
- 24-hour front desk
- Tours/ticket assistance
- Laundry facilities
- Luggage storage
- Multilingual staff
- Number of buildings/towers - 3
- Elevator/lift
- Safe-deposit box at front desk
- Rooftop terrace
- Television in common areas
In the room
- Air conditioning
- Balcony
- Private bathroom
- Bidet
- Satellite TV channels
- Phone
- In-room safe
Top Mallorca Island hotels
Recently reviewed hotels in Mallorca Island
- Boutique Hotel Posada Terra SantaFrom
"We arrived from New York a family of 10 Persons and we're sure that it will be a Little laborious to go through the process of The Chek in alas we were shocked and amazed by the…"Jul 23, 2016
- Pure Salt Port Adriano – Adults OnlyFrom
"Beautiful resort, great views of the water. Staff very friendly and helpful! We celebrated our one year anniversary hear and it was superb. We hope to come back again soon!"Jul 21, 2016
- Hotel MediodiaFrom
"I love traveling and I love the island of Palma it's very beautiful "Jul 21, 2016
- Hotel Son Matias Beach - Adults OnlyFrom
"We just had one day on the island, but this was a great overnight base. The view and location was spectacular. It seems to cater to the 50+ age group, but that included us so no…"Jul 19, 2016
Special features
DiningOnsite venue - This buffet restaurant serves breakfast, lunch, dinner, and light fare. Reservations are required.
Hotel Amic Gala, Mallorca Island's small print
Also known as
- Amic Gala
- Amic Gala Hotel
- Amic Gala Playa de Palma
- Gala Amic Hotel
- Hotel Amic Gala
- Hotel Amic Gala Playa de Palma
Cash transactions at this property cannot exceed EUR 2500, due to national regulations. For further details, please contact the property using information in the booking confirmation.
This property's policy is to refuse certain bookings for the purpose of group events or parties, including pre-wedding stag/bachelor and hen/bachelorette parties.
Only registered guests are allowed in the guestrooms.
For transfers, guests must contact the property before arrival at the number on the booking confirmation.
The name on the credit card used at check-in to pay for incidentals must be the primary name on the guestroom reservation.
Mandatory fees
You'll be asked to pay the following charges at check in or check out:
- A tax is imposed by the city: EUR 1.10 per person, per night. This tax does not apply to children under 16 years of age.
Optional extras
Cribs/Infant beds are available for EUR 5 per day
Babysitting/childcare is available for an extra charge
Airport shuttle service is offered for an extra charge
High-speed Internet access (wired) is available in public areas for an extra charge
We have included all charges provided to us by this hotel. However, charges can vary, for example, based on length of stay or the room you book.
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The Bionic Woman 1977 | TV Show Watchlist
Season 2, Episode 10 Jaime's Shield
First Aired: December 15, 1976
Jaime enrolls in a police academy to find an enemy agent among the cadets. First of two parts. Welton: George Maharis. Arleen: Diane Civita. Oscar: Richard Anderson. Parker: Rebecca Balding. Partnow: Linden Chiles. Jetton: William Bryant. Commissioner Hart: Arch Johnson. Captain Godfrey: James McEachin.
Guest Cast
George Maharis George Maharis Welton
Diane Civita Diane Civita Arleen
James McEachin James McEachin Captain Godfrey
Rebecca Balding Rebecca Balding Parker
Arch Johnson Arch Johnson Commissioner Hart
Linden Chiles Linden Chiles Partnow
William Bryant William Bryant Jetton
Cast & Details See all »
- Premiered: September 10, 1977
- Rating: None
- Premise: The Six-Million Dollar Man's former fiancée gets bionic and undertakes perilous missions for a covert government agency in this two-year spin-off from ABC's comic-book adventure hit. Like astronaut Steve Austin, Jaime Sommers' superhuman powers came courte… (more)
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PAT up22% to Rs 66.0 crore, PBT up 45% to Rs 101.5 croreOn the backdrop of a challenging business environment, Leading Asset Finance Company, Magma Fincorp Ltd. today announced a steady performance in Q4 and FY16. There is significant improvement in at-least four important areas including PBT, PAT, NIM ... 5 Dariya News - English, 2 months ago
6 images for magma fincorp limited
Rajive Kumaraswami is the new MD & CEO of Magma HDI General Insur...
Hyderabad / Kolkata, July 11 (IBNS) Rajive Kumaraswami has joined as the MD & CEO of Magma HDI General Insurance Company Limited. Kumaraswami, is an alumnus of Delhi University and a Fellow Member of the Institute of Chartered Accountants of ...India Blooms, 2 weeks ago
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