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Regado Biosciences said it will lay off 5 of its 32 full-time employees—about 15% of its workforce—just over a month after a disappointing initial public offering that raised less than what the company had hoped.
In an 8-K filing yesterday with the U.S. Securities and Exchange Commission, Regado said most of the affected employees "work in drug discovery roles at the company's laboratory facility in North Carolina." Regado also said the company needed to cut costs to continue moving into the pivotal clinical development phase of its furthest-advanced experimental drug.
"The goal of the company's reduction in workforce is to enable the company to focus its management and financial resources on advancing its lead product candidate, REG1, in its single, open-label, 13,200-subject Phase [III] trial of REG1, or the REGULATE-PCI trial," Regado stated.
Regado said Sept. 17 it enrolled its first patient in REGULATE-PCI, which is led by co-principal investigators John H. Alexander, M.D., of Duke University Medical Center; A. Michael Lincoff, M.D., of The Cleveland Clinic; and Roxana Mehran, M.D., of Mount Sinai School of Medicine. The Phase III trial will compare the effects of REG1 to bivalirudin in patients undergoing percutaneous coronary intervention (PCI) electively or for the treatment of unstable angina or non-ST elevated myocardial infarction (N-STEMI).
REG1 is a two-agent treatment consisting of highly selective Factor IXa inhibitor (pegnivacogin) and a complementary active control agent (anivamersen). Both are administered by IV bolus.
Regado shrunk its workforce some five weeks after completing an IPO that raised only $47 million, compared with the $70 million to $80 million it had hoped to raise for REGULATE-PCI. The company initially planned to sell five million shares at between $14 and $16 per share. But the stock launched on Aug. 22 with an initial share price of just $4, prompting the company to raise its number of offered shares to 10.75 million.
In December, Regado closed on $51 million of Series E venture financing led by new investor RusnanoMedInvest, a subsidiary of state-run Russian investment firm RUSNANO. Regado said at the time that "the vast majority" of the funding will be used for the Phase III development of REG1 for PCI, though some of the money was envisioned to advance other development programs, one of them REG1 for transaortic valve implantation (TAVI).
As a result of the layoffs, Regado said, it will incur about $254,225 in charges—cash charges of about $250,000 in severance costs, and $4,225 in non-cash, stock-based compensation charges. Those charges are expected to be recorded in the third quarter.
"The company believes that the reduction in workforce will result in annualized savings of approximately $625,000 beginning in the second quarter of 2014," Regado stated.
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MDMA (commonly known as the empathogen "ecstasy") is classified as a Schedule 1 drug, which is reserved for compounds with no accepted medical use and a high abuse potential. Two researchers from Stanford, however, call for a rigorous scientific exploration of MDMA's effects to identify precisely how the drug works, the data from which could be used to develop therapeutic compounds.Do you agree that ecstasy should be studied for its potential therapeutic benefits?
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[quote:Anonymous Coward 34441374:MV8yMTQyODMyXzM2MTg5MTg5X0JENTQ4NTI5] TWO BLACK HOODLUMS MURDER WHITE GIRL – [b]WHERE'S JESSE & AL?[/b] I'm sure Jesse Jackson and Al Sharpton are on their way to Clayton NJ to support the family of Autumn Pasquale and condemn the cold blooded murder of this 12 year old girl at the hands of two black hoodlums, who strangled her for her BMX bike and then dumped her body in a trash bin. What kind of evil souless scum would murder a young girl for a bike? What kind of parents raised these animals? It takes a village of lowlife entitled immoral scum of the earth to create human beings like this. I'm sure Barack Obama will be making a statement shortly about her being just like his daughter. I'm sure white people across the land will be holding BMX bike rallies and calling for justice. Oh. You don't think we'll hear a peep out of Jesse, Al or Barack? Their busy with more important stuff you say. Shocking. [/quote]
Original Message
Just a reminder! Justice is somewhere, right ?!?!?
The description of the attack is very gross, do not go forward if you have a delicate stomach.
*Wake Up White Boy*
The text description is very horrific
As horrific as this is, it needs to circulate!!!
The animals pictured below car-jacked then raped Christopher Newsom, cut off his penis, set him on fire and fatally shot him several times while they forced his girlfriend, Channon Christian, to watch. An even more cruel fate awaited her!
Channon Christian was beaten and gang-raped in many ways for four days by all of them, while they took turns urinating on her. They cut off her breasts and put chemicals in her mouth... and then murdered
Knoxville (WVLT) - The District Attorney General of Knox County announced the list of charges facing now five suspects in the double murder of Channon Christian and Christopher Newsom.
The District Attorney General Randy Nichols is not saying whether or not he will seek the death penalty, but he does say the State will seek conviction for all charges filed in a 24-page indictment from theKnox County Grand Jury. Lemaricus Davidson, 25 , faces a total of 46 charges.. Letalvis Cobbins, 24 , faces a total of 46 charges. George Thomas, 24 , faces a total of 46 charges. Vanessa Coleman, 18 , faces 40
state charges .
Eric Boyd, 24 , also arrested in connection with the fatal car jacking, only faces federal charges as an accessory after the fact.
SO!!!!! Where's Al Sharpton, O and Jesse Jackson? Are they providing counsel and help to the families of the victims?
Of course not - the victims were white!!!
Why hasn't this received National coverage by the news media like the Duke 'rape' case?
Oh, that's right - the victims were white
Why hasn't the NAACP, ACLU, New York Times etc., called for an investigation?
Must be cause the victims were white!!!
Why hasn't the FBI been called in to investigate this as a hate crime?
Oh, that's right - the victims were white!!!
So, if a white radio shock jock uses the phrase 'Nappy headed', it gets 2 weeks of constant news coverage.
If two white people are tortured, raped, and murdered by a group of black people, it barely gets a blip in the news.
Pass this around, and maybe, just maybe, it will land in the hands of someone in the media or politics, that has the guts to stand up for the white people!! Or don't because you don't have the
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Capabilities of ARA Pointman Tactical Robot Tested for Austin, Texas Use
The Applied Research Associates, Inc. (ARA) Pointman Tactical Robot was tested by police in Texas for possible deployment in Austin. The robot climbs and descends stairs, pushes doors open and is so rugged it can be thrown through a window. The robot has two cameras, the operator can monitor the live video, and it would be an asset for patrol officers. Departments would be able to send the robot into potentially dangerous areas before sending in an officer, which would eliminate the cost and time that calling SWAT requires.
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Internet Explorer
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Michel de Montaigne was one of the most influential figures of the Renaissance, singlehandedly responsible for popularising the essay as a literary form. This Penguin Classics edition of The Complete Essays is translated from the French and edited with an…
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Humanist, skeptic, acute observer of himself and others, Michel de Montaigne (1533—92) was the first to use the term "essay" to refer to the form he pioneered, and he has remained one of its most famous practitioners. He reflected on the…
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Reflections by the creator of the essay form display the humane, skeptical, humorous, and honest views of Montaigne, revealing his thoughts on sexuality, religion, cannibals, intellectuals, and other unexpected themes. Included are such celebrated works as "On…
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An Apology for Raymond Sebond is widely regarded as the greatest of Montaigne's essays: a supremely eloquent expression of Christian scepticism. An empassioned defence of Sebond's fifteenth-century treatise on natural theology, it was inspired by the deep…
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The 18th century was a wealth of knowledge, exploration and rapidly growing technology and expanding record-keeping made possible by advances in the printing press. In its determination to preserve the century of revolution, Gale initiated a…
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C# Developer Jobs in Worcestershire
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C#.NET Systems Developer - Redditch
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- An in-principle agreement has been reached between the Victorian and Federal governments to back a $56 million dollar floodplain recovery project in the Murray-Sunset National Park. ...Monday 14 January 2013
- A $56 million environmental water saving program has been announced for Victoria, but landholders say they haven't been consulted....Tuesday 15 January 2013
- To celebrate World Wetlands Day why not take a closer look at the Riverland's Bookmark Creek Wetlands....Wednesday 1 February 2012
- Caring for Yatco Lagoon is something of a birthright for this week's guest for Pass the Passion. ...Tuesday 17 January 2012
- In the last instalment of Pass the Passion for 2011 we meet a young Riverland local who mixes science with art and gets some stunning results. ...Tuesday 13 December 2011
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- Way of the water lilies: Where science meets the billabong...Thursday 7 July 2016
- Thursday 12 November 2015
- How can we define what the cost of saving a species is? How do scientists and politicians determine where funding goes when preserving and protecting various animal species? Associate Professor Nigel Andrew tells us all about the process of conservation triage. ...Tuesday 29 September 2015
- The South West and its hidden biodiversity are included in new book which takes a close look at the bigger picture....Wednesday 16 September 2015
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Surveys Find Adults with Type 2 Diabetes Are More Willing to Take Action to Achieve A1C Targets Quicker than Physicians and Other Medical Professionals Perceive
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PARIS, March 11 /TASS/. The International Energy Agency (IEA) has raised its forecast for global oil demand growth in 2016 by 200,000 barrels/day to 95.8 million barrels/day. This is according to the agency's March report.
According to the report, just like in February, the agency expects oil demand growth in 2016 at 1.2 million barrels /day as compared with 2015.
IEA also expects oil production outside OPEC to decline by 750,000 barrels/day in 2016 in comparison with 2015 to 57 million barrels /day. That is 100,000 barrels/day less than in the February forecast.
In February, oil production by OPEC decreased by 90,000 barrels/day and totaled 32.61 million barrels/day.


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BIG CREEK – Devin Elizabeth Smith Reeves King, 25, died Wednesday, June 19, 2013, as the result of an auto accident on Old Hwy. 8 at Big Creek. She was born Oct. 29, 1987, in Lawton, Okla., to Douglas Smith and Sheila Shirley Smith. She was a homemaker and wife, and a member of First […]
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By Floyd Ingram | 8:19 AM | June 21, 2013 | Obituaries
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Empty Nest 1988 | TV Show Watchlist
Season 3, Episode 8 Boy Next Door
First Aired: November 10, 1990
In a weak moment, Carol and Charley (Dinah Manoff, David Leisure) turn to each other for comfort. Cindy: Candy Hutson. Ashley: Ashley Bank. Michael: Michael Melby. Mrs. Hill: Gloria Dorson. Harry: Richard Mulligan.
Guest Cast
Candy Hutson Candy Hutson Cindy
Gloria Dorson Gloria Dorson Mrs. Hill
Michael Melby Michael Melby Michael
Ashley Bank Ashley Bank Ashley
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- Premiered: October 8, 1988
- Rating: None
- Premise: A popular spin-off of `The Golden Girls' about widowed Miami doctor Harry Weston, who leaves the light on when two of his grown daughters return home (the third daughter appeared briefly in 1993). Richard Mulligan won an Emmy the first season, and earned n… (more)
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Eliza Gettel '12, of Merrimack, N.H., has received a Fulbright grant to pursue a master of arts in social archaeology at the University of Southampton in the U.K. next year. Before commencing the one-year postgraduate studies program, the classics major will travel to London for a three-day Fulbright orientation in September.
"Social archaeology uses material culture to study interpersonal relationships and the connection between people and objects," she says.
During her Fulbright year, Gettel, who is in the College Honors Program, will build upon her two undergraduate theses and study the influence of antiquity on modern Greek politics. In addition, she will continue her work with odea, ancient roofed theaters, which she has researched in Athens and Rome during academic year abroad programs. Gettel has also spent time abroad on archaeological projects in Bir Madhkur, Jordan and Athens.
After her year at the University of Southampton, Gettel will return to the United States to pursue a Ph.D. in classics and ancient history at Harvard University, where she has already been accepted.
Gettel plans to become a professor of classics, which will allow her to teach about the ancient world and its modern legacy.
"I aspire to become a professor who integrates historical and archaeological evidence to gain greater understanding of the ancient world and what it means to modern society," says Gettel.
At Holy Cross, Gettel is a member of Phi Beta Kappa, an academic honor society that celebrates and advocates excellence in the liberal arts and sciences, and is an executive member of Eta Sigma Phi, the national honorary collegiate society for students of Latin and Greek. Gettel serves her peers as a trained tutor in the on-campus Writer's Workshop and also works with first-year writers as a Writing Fellow through Montserrat. In addition, she is an active member of the Purple Key Society, a service organization that fosters school spirit, loyalty and enthusiasm through campus events.
Each year approximately 1,000 college students are awarded grants through the Fulbright Program, the U.S. government's flagship program in international educational exchange. Fulbright grants are made to U.S. citizens and nationals of other countries for a variety of educational activities, primarily university lecturing, advanced research, graduate study and teaching in elementary and secondary schools. Since the program's inception in 1946, more than 300,000 participants — chosen for their leadership potential — have had the opportunity to observe each other's political, economic and cultural institutions.
Read about this year's other Holy Cross Fulbright Grant recipients: Joseph Cavanaugh '12, Mattea Cumoletti '12, Caroline Galiatsos '12, Daniel Geiger '11, Heidi Grek '12, Maria Jaroszewicz '12, Jaeyeon Lee '12, Courtney Lesoon '12, George Matthews '12 and Peter Renehan '12.
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Sugary treats ruled out for primary school pupils
Student council members hatch dariy planLIBBY WILSON
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An early-morning sugar fix and a Rhode Street School uniform don't go together any more, thanks to an agreement between the student council and several Dinsdale dairies.
When student council members realised how much some pupils were buying, they started asking local dairies not to sell sugary drinks and lollies to students in uniform either before or after school.
So far two have signed up - Irvine Street Dairy and K Road Dairy and Flowers, and the Blackburn Street Superette has agreed for mornings.
Some pupils support the idea and others are mourning the loss of their chance to get lollies on the way to or from school, student council member Alexandria Blair said.
"When they grow up they're probably going to thank us because they won't get diabetes."
The idea was born after she and fellow council member Te Arahau Reihana noticed their class "was getting a bit crazy in the mornings".
Last week they realised why - a bag check revealed more than $150 worth of lollies from about 50 students.
So they hatched the dairy plan and she's happy with the support they've received so far.
"I think this might actually trigger some people's thoughts. They might actually say, 'Oh yeah, this is a good idea. It'll make our children healthier and boost their learning'."
But they're planning to keep the dairy signatories honest with a kind of sting in a few weeks' time, she said.
Te Arahau said he felt a bit nervous when they went into the dairies with their proposition.
"We weren't entirely sure whether they'd agree with us or whether they'd think it's a bad idea," he said.
But he'd been shocked by Ministry of Health statistics showing one-in-five children were overweight and teachers at school were having to take learning time to settle students who were high on sugar.
There were seven dairies around the school and principal Shane Ngatai said they were hoping to get them all on board as a way of helping kids make better choices.
"We are going to see some resistance but I think we've got some really brave dairy owners here to say they're prepared to support this. It just makes it easier for us as a school," he said.
"When you get a community on board with supporting what your vision is then it's not a rule. It's an agreement. And we're all agreeing to support each other by living up to this agreement that we've got in place."
For Jagdish Patel, owner of K Road Dairy and Flowers, signing the agreement was an obvious choice.
"It's good because, morning time, lollies is no good," he said.
"It's good for the kids . . . better for their health."
- Waikato Times
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Recently on the U.S. border with Mexico, a Border Patrol officer was caught with no backup while facing an angry mob of illegal aliens bent on crossing into the United States.
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Of all training accidents, police officers shooting each other in simulation drills are the most tragic. They are also the most difficult for some officers and civilians to comprehend.
Two young guys walked toward us, talking with each other. But the young lady and I were oblivious to what was going on around us. That was a mistake.
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As a former Federal Air Marshal, I am often asked, "Should law enforcement officers be allowed to carry their guns when they are passengers on commercial airliners?" My short answer is, "Hell, yes."
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As police officers on the streets of our cities, you face potentially deadly disguised and hidden weapons every single day.


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Perform design, development, coding, testing, research, programming and documentation for software systems, applications and/or operating systems in conjunction...
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SOFTWARE ENGINEER - Monitoring. We are currently seeking a Software Engineer to join our dynamic network engineering team....
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This ring has a copper disc that has been given a slight curvature and a pale blue moonstone sits inside. The ring was given a slightly darkened patina. This ring is just between a size 8 and 8.5. This piece has been sealed with a lacquer and wax to protect its finish. Please read all shop policies for care of this piece before purchasing!
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London's Tube system is the world's first ever underground transport system. With over 250 miles of track and 270 stations, it's an attraction in itself. This book showcases some of the hidden delights you can find on each line.
- £3.99
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The tube can take you wherever you want to go in the ever-fascinating city of London and this book inspires you to venture a little further afield to discover even more surprises.
With over 600 square miles to explore, the book highlights some of the iconic sights, historic buildings, marvellous museums and vibrant markets you'll find just a short walk from some of the famous stations.
The only collection of biking tours of its kind in the UK, Bikers' Britain: The Tours features over 40 all-new routes that you'll love riding along.
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Compiled by Simon Weir, the man behind the routes featured in RiDE magazine, the wiro-bound book has been especially designed to it can fit into a motorcycle tank bag. The clear routes are based on AA atlas mapping from expert cartographers and range from circular day tours to multi-day regional tours.
As well as practical advice on preparing for a trip including clothing, safety and bike maintenance, each route in the book is accompanied by sights to see and things to do.
A famous city packed with public houses, A London Pub for Every Occasion showcases 157 of the English capital's finest watering holes - from the comfy to the brilliantly bizarre!
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Scanning across the whole city, this book from Herb Lester Associates will introduce you to a new favourite pub. Whether you have friends to meet or just want to be alone; want to bring a dog or enjoy the company of the resident pub cat; just want to relax in the garden or enjoy a live act, this book can help you find London's finest pub to do so.
Whether you're an armchair traveller or you're looking for inspiration for a great day out, Suzannah Lipscomb's A Visitor's Companion to Tudor England is a practical guide that will take you to palaces, castles, theatres and abbeys that uncover the true stories behind Tudor England.
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From Hampton Court to Hever Castle, this lively and engaging hardback guide reveals the rich history of the era and invites you to visit the many places in which Tudors once lived, worked and played.
A must for anyone interested in this fascinating period of English history.
From Dartmoor to Loch Lomond and the Trossachs, this book will help you discover the beauty of Britain's national parks. Published by the AA, it also has detailed maps of each park for you to pore over and plan your next trip.
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Very much the jewels in the crown of the countryside, the national parks represent the finest protected landscapes in England, Wales and Scotland. You'll be able to discover the hidden secrets of each park and their wildlife, history, heritage and so much more.
With breathtaking photography throughout, Roly Smith's lively text gives a comprehensive overview of all the beautiful parks including the mountains of the Lake District and wooded valleys of the south west.
Lonely Planet: The world's leading travel guide publisher Lonely Planet Europe is your passport to the most relevant, up-to-date advice on what to see and skip, and what hidden discoveries await you. Tour French chateaux, take boat trips to Greek beaches, hike past Bulgarian monasteries and glug Spanish wine; all with your trusted travel companion. Get to the heart of Europe and begin your journey now! Inside Lonely Planet Europe Travel Guide: *Colour maps and images throughout *Highlights and 3-6 week itineraries help you tailor your trip to your personal needs and interests *Insider tips to save time and money and get around like a local, avoiding crowds and trouble spots *Essential info at your fingertips - hours of operation, phone numbers, websites, transit tips, prices *Honest reviews for all budgets - eating, sleeping, sight-seeing, going out, shopping, hidden gems that most guidebooks miss *Cultural insights give you a richer, more rewarding travel experience - history, art, literature, cinema, landscapes *Useful features including Need to Know, If You Like, Month by Month *Over 200 maps *Covers Austria, Belgium, Britain, Bulgaria, Croatia, Czech Republic, France, Germany, Greece, Hungary, Ireland, Italy, Montenegro, Netherlands, Poland, Portugal, Romania, Russia, Scandinavia, Serbia, Spain, Switzerland, Turkey, Ukraine and more The Perfect Choice: Lonely Planet Europe is perfect for experiencing all the continent has to offer on a wide range of budgets. * Looking to make the most of your budget for a longer, multi-country trip? Check out Lonely Planet Europe on a shoestring, a comprehensive guide for connecting with the cultures and exploring both top sights and roads less travelled. * Looking for just the highlights? Check out Discover Europe, a photo-rich guide that focuses on the top experiences. * Looking for just a few of the destinations included in this guide? Check out the relevant Lonely Planet destination guides, our most comprehensive guides that cover both top sights and offbeat experiences, or check out our photo-rich Discover or Best of guides, which focus on destinations' most popular attractions. Authors: Written and researched by Lonely Planet, Alexis Averbuck, Carolyn Bain, Mark Baker, Kerry Christiani, Marc Di Duca, Peter Dragicevech, Mark Elliott, Steve Fallon, Emilie Filou, Duncan Garwood, Anthony Ham, Catherine Le Nevez, Jessica Lee, Tom Masters, Anja Mutic, Sally O'Brien, Becky Ohlsen, Simon Richmond, Andrea Schulte-Peevers, Tamara Sheward, Helena Smith, Andy Symington, Luke Waterson and Neil Wilson. About Lonely Planet: Since 1973, Lonely Planet has become the world's leading travel media company with guidebooks to every destination, an award-winning website, mobile and digital travel products, and a dedicated traveller community. Lonely Planet covers must-see spots but also enables curious travellers to get off beaten paths to understand more of the culture of the places in which they find themselves.
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(Re)discovering Europe. Dream weekends with practical itineraries from Paris to Perm. Culture, history, natural beauty, fine cuisine, artistic masterpieces, cutting-edge architecture and style - Europe overflows with so many riches that a lifetime seems too short to appreciate them. But with the right guidance, you can go far in a single weekend. Stylishly written and carefully researched, this updated and expanded collection of the popular "New York Times" "36 Hours" feature offers you 125 well-crafted itineraries for quick but memorable European trips, accompanied by hundreds of color photographs to fire your imagination. You can explore the expected: the Renaissance in Florence, surfing in Biarritz, flamenco in Seville. And discover the unexpected: Sicilian mummies dressed in their Sunday best, a dry-land toboggan ride on Madeira, a hotel in Tallinn with a KGB spies' nest on the penthouse floor. Your guides are seasoned "New York Times" journalists and savvy travel writers. Elaine Sciolino, a longtime foreign correspondent, offers three tours of Paris and a side trip in southern France. Frank Bruni, the "Times" op-ed columnist and food writer, advises on pizza and priceless art in Rome. Matt Gross, the Frugal Traveler, takes you to a gorgeous beach in Poland. With the peripatetic author Tony Perrottet, follow the footsteps of Lord Byron and the Shelleys around Lake Geneva. And Seth Sherwood, one of America's liveliest and most prolific travel writers, lays out a dozen weekends from Copenhagen to St.Tropez. World capitals, ancient nations that once ruled wide domains, tiny countries with big personalities - it's all Europe, and all fun to read about (whether you actually go or not) in this handsomely designed and illustrated book. It features: 4,500 hours worth of insightful itineraries to make the most of your stay; 125 European destinations, from major cities to lesser known gems; practical recommendations for over 500 restaurants and 400 hotels; color-coded tabs and ribbons to bookmark your favorite cities in each region; nearly 800 photos, most of them from "The New York Times" archive; all stories have been updated and adapted for this volume by Barbara Ireland, a veteran "Times" travel editor; new illustrations by "Times" illustrator Olimpia Zagnoli of Milan; easy-to-reference indexes; and detailed city-by-city maps pinpoint every stop on your itinerary. Also available: "36 Hours: 150 Weekends in the USA & Canada".
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The Rough Guide to Budapest is the ultimate travel guide to one of Europe's most fascinating and dynamic cities. In full colour throughout, with dozens of colour photos to illustrate the finest of Budapest's great buildings, landmarks and distinctive neighbourhoods, this guide will show you the best the city has to offer. Whether you want high culture or a thriving underground club scene - including the city's unique "ruin pubs" - haute cuisine or pampering in spas, Budapest is the place to come. Easy-to-use maps for each neighbourhood make getting around easy. With detailed chapters featuring all the best hotels, restaurants and cafes, pubs and bars, live music and clubs, shops, theatre, kids' activities and more, you'll be sure to make the most of your time in the city with The Rough Guide to Budapest. Make the most of your time on Earth with The Rough Guide to Budapest.
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The fully updated and redesigned ninth edition of The Rough Guide to Prague - now in full colour throughout - is the definitive guide to this beguiling city, with its stunning architecture, turbulent history and top-notch art collections. Read expert background on everything from the enormous Prague Castle complex to relaxing Vltava cruises, and find comprehensive information on the best hotels, pubs, clubs, shops and restaurants for all budgets. The introduction will help you choose where to go and what to see, inspired by dozens of stunning photos. The Things Not To Miss section runs through all the must-sees, while the Itineraries guide you around the city's highlights. Navigation through the book and on the ground is aided by clear colour maps with every chapter. Each one is keyed with all the accommodation, eating and drinking options, nightlife venues and shops that are reviewed in detail in our Listings chapters. You'll also find practical advice on a selection of day-trips from Prague including the Gothic town of Kutna Hora, thought-provoking Terezin and the magnificent Karlstejn Castle. And if you're after fast-fix 'Top 5 boxes' that pick out the highlights you won't want to miss, The Rough Guide to Prague won't let you down! Make the most of your time on Earth with The Rough Guide to Prague.
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Insight Guide Turkey is a comprehensive full-colour guide to the culture, history and people of this varied and youthful country. Be inspired by our Best of Turkey section highlighting unmissable sights and experiences and lavish Photo Features on topics such as Turkish cafes, carpets and kilims and the great outdoors. A detailed Places section, with stunning travel photography and full-colour maps, shows you where to go and what to do, from the bright lights of Istanbul to ancient monuments, amazing landscapes and characterful old towns - making sure you don't miss anything. A comprehensive Travel Tips section gives you all the travel advice you need to plan your trip, with our selective, independent reviews to guide you to the most authentic hotels and restaurants.
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This title is presented in quick, easy-to-use and a perfect size to fit in your pocket. It is organized by subjects such as everyday phrases, hotels, travelling around and includes an extensive menu section. It uses a simple and effective system of imitated pronunciation.
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Ann Cleeves' bestselling series starring Detective Jimmy Perez has been a favourite with crime fans for years and the BBC adaptation of Shetland has brought her many more fans. This companion to the novels shows the readers exactly what this incredible location can offer.
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An archipelago of more than 100 islands, Shetland is one of the most remote places in the United Kingdom and its 1,500 miles of shore means that wherever you stand, you'll have a view of the sea. Traditions are valued and celebrated on the islands, but new technologies and ways of working are also embraced.
Gloriously illustrated, this companion finds Ann Cleeves learning about the islands' past, people, the festivals that take place upon them and discovering how flora and fauna changes throughout the seasons. It's a lavish book that vividly captures Shetland in all its bleak and special beauty.
This brand new Standard Dictionary has a long-lasting vinyl cover and is exceptionally easy to use. It features up to 130,000 entries, covering a wide range of vocabulary plus many idiomatic expressions too. Extra grammatical information will extend your knowledge of the language even further. A clear layout along with bright, blue headwords enables you to navigate around the book quickly so you will be finding the words you need in no time at all!
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Discover Scandinavia, this wonderful region of fjords, tall mountains, rich folklore and cool design and be inspired by this new edition of Insight Guide Scandinavia, a comprehensive full-colour guide to this breathtaking region whose New Scandinavian Cuisine has taken the world by storm. Be inspired by our Best of Scandinavia section highlighting unmissable sights and experiences and lavish Photo Features on topics such as saunas, folklore and foraging. This book includes a detailed Places section, with stunning travel photography and full-colour maps, shows you where to go and what to do, from from the fjords of Norway to the cool cities of Stockholm and Copenhagen and the saunas of Finland. This is a comprehensive Travel Tips section gives you all the travel advice you need to plan your trip, with our selective, independent reviews to guide you to the most authentic nightlife venues and restaurants.
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Kayak in the serene Lakeland, enjoy a cruise on the Baltic, or take in the splendour of the Northern Lights in Lapland - Insight Guide Finland helps you get the best out of this outdoor paradise. The guide has been fully updated by our expert Scandinavia author for this new edition, which also features Insight's trademark stunning photography and more information on culture and history than any other guide. Whether you're heading for the cool capital, Helsinki, or Lapland in the far north, this book tells you everything you need to know, and also helps you enjoy all the unmissable Finnish experiences, such as relaxing in a traditional sauna and cycling around the gorgeous Aland archipelago. Full-colour, highly detailed maps throughout will help you get around and travel tips give you all the information you need to plan a memorable trip, including our selection of the best and most authentic hotels and restaurants.
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The eighth edition of the Rough Guide to Wales is the ultimate travel guide to this incredibly varied country, with stunning photography throughout. Whether you want to trek the Pembrokeshire Coast Path or let loose at Green Man festival, have a slap-up meal in foodie Abergavenny or chug through the Snowdonia mountains on the Ffestiniog Railway, you'll find all the practical details and inspiring ideas you'll need. Spanning the length and breadth of Wales, from tiny valley towns to bustling cities, this is the most comprehensive guide to the country. Plan your trip using our colour-coded maps and up-to-date listings on the best places to stay, eat and drink in every corner of Wales. Whether you want detailed background or a quick idea of the highlights of each region, The Rough Guide to Wales has it all. Make the most of your time on Earth[trademark] with The Rough Guide to Wales.
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"Insight Guide Malta" offers a unique approach to getting the most out of one of Europe's most fascinating destinations. Engaging History and Culture chapters explain the island's intriguing past as a gateway between Europe and the Arab world, and the factors influencing its future - from ancient temples to the impact of joining the Eurozone. The burgeoning arts scene, architectural treasures, local cuisine and folklore are fully explored as contributors to the island's culture and character. Colourful, magazine-style features focus on what makes Malta unique - the impressive archaeology, the legacy of the Knights of St John and British rule, and the exuberant festivals that take place every summer. Malta is also now one of the world's foremost diving destinations and this guide investigates the fantastic range of diving opportunities available on the islands. The Places chapters cover Malta and Gozo in detail and suggest excursions to the surrounding islands. Full-colour photographs throughout give a true flavour of contemporary life on the islands. Detailed maps plot all major sights, and the Travel Tips offer selective listings for the best places to stay and eat, and where to take part in outdoor activities.
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Let "The Rough Guide to Sweden" shows you the very best this unspool country has to offer: from the style-conscious capital, Stockholm, with its magnificent archipelago, to the vast pine forests of Swedish Lapland. Spend a night in the world-famous Ice hotel inside the Arctic Circle or laze on the sunny, sandy beaches of the Baltic island of Gotland - Sweden is much more than flat-pack furniture and meatballs. "The Rough Guide to Sweden" includes full color pictures to inspire your travels through this vast country of forests and lakes, detailed maps to help you on your way and expert background on everything from smorgasbords to saunas. With The Rough Guide to Sweden in your hand, you'll find that Sweden offers superb value for money and is a gem waiting to be discovered - where seemingly everyone speaks perfect English. Make the most of your time with "The Rough Guide to Sweden".
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This guide presents top-class walking routes in Northern Ireland. From rugged mountain peaks to spectacular coastal scenery, from challenging hill walks to shorter woodland and waterside excursions, there is something for everyone. Every part of the region is covered, from the mountains of Mourne to the Giant's Causeway, from Fermanagh's 'lake district' to the rolling Sperrins. Routes vary from two-hour strolls to eight-hour upland challenges. Much thought has gone into making this guide easy to use: each route, prefaced with a quick-reference summary, is illustrated with a clear sketch map; descriptions include detailed access information while points of interest are highlighted - flora and fauna, history, archaeology and folklore. A compact region with huge scenic variety, Northern Ireland is ideal for walking yet is often overlooked. This authoritative guide is changing that, using the author's enthusiasm and knowledge.
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DK Eyewitness Top 10 Travel Guide: Prague will lead you straight to the very best on offer. Whether you're looking for the things not to miss at the Top 10 sights, or want to find the best nightspots; this guide is the perfect pocket-sized companion. Rely on dozens of Top 10 lists - from the Top 10 museums and galleries to the Top 10 greatest Czech writers and composers - there's even a list of the Top 10 things to avoid. The guide is divided by area with restaurant reviews for each, as well as recommendations for hotels, bars and places to shop. You'll find the insider knowledge every visitor needs and explore every corner effortlessly with DK Eyewitness Top 10 Travel Guide: Prague and its FREE pull-out map. DK Eyewitness Top 10 Travel Guide: Prague - showing you what others only tell you.
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The DK Eyewitness Travel Guide: Denmark is your indispensable guide to this beautiful part of the world. The fully updated guide includes unique cutaways, floorplans and reconstructions of the must-see sites, and street-by-street maps of all the fascinating cities and towns. The new-look guide is also packed with photographs and illustrations leading you straight to the best attractions on offer. The uniquely visual DK Eyewitness Travel Guide: Denmark will help you to discover everything region-by-region; from local festivals and markets to day trips around the countryside. Detailed listings will guide you to the best hotels, restaurants, bars and shops for all budgets, whilst detailed practical information will help you to get around, whether by train, bus or car. Plus, DK's excellent insider tips and essential local information will help you explore every corner of Denmark effortlessly. DK Eyewitness Travel Guide: Denmark - showing you what others only tell you.
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DK Eyewitness Top 10 Travel Guide: St. Petersburg will lead you straight to the very best on offer. Whether you're looking for the things not to miss at the Top 10 sights, or want to find the best nightspots; this guide is the perfect pocket-sized companion. Rely on dozens of Top 10 lists - from the Top 10 museums to the Top 10 events and festivals - there's even a list of the Top 10 things to avoid. The guide is divided by area with restaurant reviews for each, as well as recommendations for hotels, bars and places to shop. You'll find the insider knowledge every visitor needs and explore every corner effortlessly with DK Eyewitness Top 10 Travel Guide: St. Petersburg and its free pull-out map. DK Eyewitness Top 10 Travel Guide: St. Petersburg - showing you what others only tell you.
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"Berlitz Pocket Guide France" is a concise, full-colour travel guide that combines lively text with vivid photography to highlight the very best that this beautiful country has to offer. The Where To Go chapter details all the key sights on a tour of both mainland France and Corsica, from the dazzling heights of the Eiffel Tower to the sun-drenched lavender fields of Provence and Riviera glitz, via the sophisticated castles of the Loire Valley and the natural splendour of the Mont-St-Michel. Handy maps on the cover help you to get around with ease. To inspire you, the book offers a rundown of the Top 10 Attractions in France, followed by an itinerary for a Perfect Tour of the country. The What to Do chapter is a snapshot of ways to spend your spare time, from shopping and sports to hip jazz clubs and festivals. You'll also be armed with background information, including a brief history of the country and an Eating Out chapter covering its world-famous cuisine. There are carefully chosen listings of the best hotels and restaurants, and an A-Z to give you all the practical information you will need.
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The DK Eyewitness Bulgaria Travel Guide is your indispensable guide to this beautiful part of the world. The fully updated guide includes unique cutaways, floorplans and reconstructions of the must-see sites, plus street-by-street maps of all the fascinating cities and towns. The new-look guide is also packed with photographs and illustrations leading you straight to the best attractions on offer. The uniquely visual DK Eyewitness Travel guide will help you to discover everything region-by-region; from local festivals and markets to day trips around the countryside. Detailed listings will guide you to the best hotels, restaurants, bars and shops for all budgets, whilst detailed practical information will help you to get around, whether by train, bus or car. Plus, DK's excellent insider tips and essential local information will help you explore every corner of Bulgaria effortlessly. DK Eyewitness Bulgaria Travel Guide - showing you what others only tell you.
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The third annual "Hallelujah Crab Feed" to benefit the Northern California Race Track Chaplaincy is March 10 at the Bay Meadows clubhouse.
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|By Peter Silva
Article Rating:
|December 12, 2012 08:28 AM EST
Like last year, everyone has their Technology predictions with their annual lists for the coming year. Instead of coming up with my own, I figured I'd simply regurgitate what many others are expecting to happen.
Cloud computing in 2013: Two warnings: @DavidLinthicum has his two tragic cloud computing predictions for 2013 (price wars & skills shortage). Nice to see some realism mixed with all the 'this is the greatest.'
10 Cloud Predictions for 2013: CIO has an interesting slide show covering things like Hybrid Cloud, Management, Brokers, SDN, Outages and a few other critical components.
RSA's Art Coviello: 8 Computer Security Predictions For 2013: Attacks grow, Hackers grow, business's not prepared grows along with investment, analysis and intelligence to mitigate threats.
Security Predictions 2013-2014: Emerging Trends in IT and Security: SANS gets some input from various industry folks on what they think. Areas like authentication, mobile devices, Windows 8, geo-forensics, gamification and others are highlighted
Top 6 security predictions for 2013: InformationWeek India lists FortiGuard Labs predictions covering APT, two factor auth, M2M exploits. mobile malware, and botnets.
Tech Guru Mark Anderson's Top 10 Predictions For 2013: Forbes' list is cool since it goes beyond just security, cloud and IT. Yes, mobile and hacktivism are covered but also Driverless Cars, eBooks, Net TVs and the LTE vs. Fiber battle.
Top predictions, about IT predictions, for 2013: Of course I love the title and this article digs into the question of 'is any real insight uncovered' with these predictions?.
Forrester: Networking predictions for 2013: ComputerWeekly shares 4 of Forrester's report on eight critical predictions for 2013. SDN, WLAN, Strategic sourcing and staffing make the list.
7 Predictions for Cloud Computing in 2013 That Make Perfect Sense: Back to Forbes again, this time specific to cloud. Private clouds, personal clouds, community clouds, cloud brokers, and even a prediction that the term 'cloud' starts to fade.
2013 Astrology Predictions: Gotta have a little fun and give you something to look forward to based on your astrological sign. That is, of course, if we make it past Dec 21.
Certainly not even close to an exhaustive list of all the various 2013 predictions but a good swath of what some experts believe is coming.
OK, and here are just a few of my own:
BYOD Matures – instead of managing entire device, only those corporate apps and data will be in control. Mobile Security and BYOD come together. Also, things like cars and TVs that have internet connections will get added to the BYOD realm. Why couldn't a road warrior access his VDI from the car's NAV screen? Why couldn't someone check their email between commercials. Anything with an IP and screen is game.
Major Mobile Malware – we've seen some here and there but think there will be a big jump in attempts to get at device's info…especially as more BYOD gets deployed.
Cloud Classification (Pub/Pri/Hy) – lines become even more blurry as they all are used to create Hybrid Infrastructures. No one cloud will take over but will be a part of the entire infrastructure which includes in-house, cloud, leased raised floor, and just about any place that data can live. There might also be some movement on Cloud Standards.
More Breaches/DoS/Hacktivism – if 2012 is any indication, this will continue.
Hacker Defection – I think there will be more ex-malicious hackers going mainstream and joining legit companies – and they will expose some of the tricks of the trade.
The Top 10, Top Predictions for 2012
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Whether your IoT service is connecting cars, homes, appliances, wearable, cameras or other devices, one question hangs in the balance – how do you actually make money from this service? The ability to turn your IoT service into profit requires the ability to create a monetization strategy that is flexible, scalable and working for you in real-time. It must be a transparent, smoothly implemented strategy that all stakeholders – from customers to the board – will be able to understand and comprehe...
Jul. 24, 2016 08:30 AM EDT Reads: 2,067
It's 2016: buildings are smart, connected and the IoT is fundamentally altering how control and operating systems work and speak to each other. Platforms across the enterprise are networked via inexpensive sensors to collect massive amounts of data for analytics, information management, and insights that can be used to continuously improve operations. In his session at @ThingsExpo, Brian Chemel, Co-Founder and CTO of Digital Lumens, will explore: The benefits sensor-networked systems bring to ...
Jul. 24, 2016 08:30 AM EDT Reads: 1,473


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Crazy Substitute Teachers
Enjoy, NG4.04 / 5.00 1,421 Views
Vacuum Salesman
This dude and his Megazord vacuum cleaner3.98 / 5.00 2,396 Views
Markiplier Animated | Mark Of The Survey Corps
This took far too long to make...3.94 / 5.00 3,711 Views
I'd buy the manga but I can't find it anywhere...
Except your website, and, no offense, I don't trust delivery online services.
I thought I was the only one that still remebered that Lodoss animes/mangas..
It looks very good...
Right now I can't think of any suggestions.
I've been trying to follow Drowtales online, til I got lost and just decided to start buying the manga. Anyway, isn't Ariel Drow/Spyder or something like that?
I Love it but...
...why are there moons and clouds when the place (Orthorbbae Cavern) is underground?Other than that i love it oh and also I like the Orthorbbae dorm room background or whatever it is.
From what the comic artist told me, the sky is a magic projection on the ceiling, not a real sky.
great animation
the monement was very smooth and the voice seems to fit however it was sort of annoying that i coudnt pause it. oh and to Flipperthepriest the series is nowhere near finished


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Drake and Blake Griffin performed a funny skit at the 2014 ESPYs that are live right now. Drake and Blake start out as good buddies, and then evolve into enemies after a small argument over a film title. Hilarity ensues after that when they go after each other.
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