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Leasing, retail, hotel, hospitality. This individual will excel at building relationships, overcoming objections and poses impressive customer service skills...
Jul 1 - Laurel, MD
Consistently delivers a high level of service and hospitality to our customers. Ensures that café meets the company average customer service score from the QSC...
Jul 26 - Washington, DC
Learning Business Partner - Retail & Hospitality. NCR's assisted- and self-service solutions and comprehensive support services address the needs of retail,...
May 4 - United States
High energy and dedication to customer service. Jason's Deli is Now Hiring Assistant Managers for our *Timonium, Columbia, and College Park locations in...
Jul 29 - Baltimore, MD
Customer service, guest service, part-time hotel job, part time hotel job, concierge, front desk clerk, full-time hotel job, full time hotel job, night service...
Apr 26 - Baltimore, MD
Restaurant General Manager
General Manager
Casual Theme-Energetic, Expanding Concept
As a General Manager for our company you will be given the opportunity to work for the best and most exciting restaurant you have ever worked for……seriously! We do things our own way, which is slightly off-beat. Our way makes heading out in the arctic temperatures to terrible seats and overly expensive stadium beers feel like a second ...
Jul 30 -
Business Consultant - Professional Services Travel. Strong execution that helps customers quickly see maximum value from our consulting engagements....
Jul 11 - United States
Assistant General Manager
Assistant General Manager
Fast Casual- Industry Leader
Our company is seeking an enthusiastic Assistant General Manager and a great motivator to join our team. Is your focus on your guests' experience, anticipating and understanding guests' needs and exceed their expectations? If this sounds like the kind of Assistant General Manager you are or want to be we need to hear from you!! Apply ...
Jul 30 -
Bel Air
Develop and maintain a deep understanding of customer needs and requirements. Help customers identify solutions to problems they did not know they had....
Apr 20 - United States
FOH Manager/ Bar Manager - Fun Establishment
We are seeking a FOH Manager Bar Experience to join our team! You will be responsible for providing customers with a memorable dining experience. Responsibilities:Supervise and coordinate all culinary activitiesOversee guest services and resolve issuesEnsure a high quality of ingredients and food preparationTrain and manage kitchen personnelCreate and adjust staff schedules to meet restaurant ...
Jul 28 -
Embassy Suites Baltimore is looking for energetic customer service oriented individuals to join our team!...
Jul 18 - Linthicum Heights, MD
Restaurant Manager
We are seeking a Restaurant Manager to join our team! You will be responsible for providing customers with a memorable dining experience. Responsibilities:Supervise and coordinate all culinary activitiesOversee guest services and resolve issuesEnsure a high quality of ingredients and food preparationTrain and manage kitchen personnelCreate and adjust staff schedules to meet restaurant ...
Jul 28 -
To maintain the companies high standard of service and hospitality. Provide the highest quality of service to the customer at all times....
Jun 27 - Linthicum, MD
Ruby 8 Noodles and Sushi at McHenry Row. Enjoy fresh sushi to oyster with a Asian cuisine menu. We will also have happy hour and a full bar service.
Legally eligible to work in the US
Speaks English
Customer service
Point of sales systems
Explaining and upselling menu items
Clean appearance
Food Service experience
Can stand for several hours a day
Bussing tables
Able to multi ...
Jul 24 -
May 25 - Linthicum, MD
Ruby 8 Noodles and Sushi at McHenry Row. Enjoy fresh sushi to oyster with a Asian cuisine menu. We will also have happy hour and a full bar service.
Legally eligible to work in the US
Speaks English
Work in a fast-paced environment
Food Handler Card
Explaining and upselling menu items
Food Service experience
Customer service
Clean appearance
knowledge of alcohol drinks
Can ...
NCR's assisted- and self-service solutions and comprehensive support services address the needs of retail, financial, travel, hospitality, gaming, public sector...
Apr 15 - United States
Asst. Food and Beverage Operations Manager - Marriott Hotels (160011I2
Asst. Food and Beverage Operations Manager
It's a powerful feeling, to belong. It's inspiring people to do more than they thought they could. It's leading the way by rolling up your sleeves to accomplish a common goal. It's taking a passion and turning it into your vision. Belonging is what it feels like to work at Marriott. If this sounds like the place for you, join us.
The BWI Airport ...
Jul 22 -
Linthicum Heights
Superior customer service approach, team building and conflict resolution skills. Knowledge of the principles and processes for providing personalized services...
Jun 1 - United States
Part Time Delivery Driver
At Peapod, we aren't just putting groceries into boxes. . .we are feeding families. Our customers trust us to carefully select, pack, and deliver for them the quality food that they would pick themselves. We want high caliber individuals to join our warehouse team in Hanover, MD (near Arundel Mills Mall) to help us "Amaze & Delight" our customers and keep that trust that they place in us ...
Jul 22 -
Jul 13 - Hanover, MD
Full Time Delivery Driver
Jun 29 - Hanover, MD
Sr. Event Services Manager - Baltimore Marriott Waterfront (16001103)
Sr. Event Services Manager
It's a powerful feeling, to belong. It's inspiring people to do more than they thought they could. It's leading the way by rolling up your sleeves to accomplish a common goal. It's taking a passion and turning it into your vision. Belonging is what it feels like to work at Marriott. If this sounds like the place for you, join us.
The Baltimore Marriott Waterfront ...
Jul 21 -
Excellent customer service/people skills. This position is ideal for someone who has customer service skills and wants to work in an office environment....
Jul 28 - Baltimore, MD
Energetic Marketing Firm Seeks Restaurant & Hospitality Experience
Energetic Marketing Firm Seeks Restaurant, Retail, Hospitality Experience for Management Training! Does your wrist hurt from carrying trays?Got spinach dip stains on your favorite clothes?Tired of spending your entire paycheck so that you can dress in your employer's products?Fed up with customers who think that 15% is a GREAT TIP? If you are ready for a career change or you just haven't been ...
Jul 19 -
Restaurant / Retail / Customer Service Experience Wanted!
Advantage Concepts Inc represents industry leaders in the telecommunications industries. Our strength is our ability to provide measurable results of our efforts directly to our clients. This has allowed us to expand and thrive in a struggling economy. We have a fast-paced work environment filled with motivated and talented individuals that work together to build their careers while enhancing ...
Fast Casual Manager
Filename Panera Bread - Restaurant Manager
Title Restaurant Manager
Description Do you want to join the fastest expanding company in the United States as a Restau...
Restaurant Manager
America's Fastest Growing Concept
Do you want to join the fastest expanding company in the United States as a Restaurant Manager and increase the success of one of our booming markets? We are seeking ...
Jul 19 -
Bel Air
Hotel Guest Service Manager
As Guest Services Manager, you would be responsible for managing the Guest Services operations in the hotel's continuing effort to deliver outstanding guest service and financial profitability. Specifically, you would be responsible for performing the following tasks to the highest standards:Oversee daily operations in all Guest Services departments and manage all Guest Service operations to ...
Jul 19 -
Customer Service / Sales Account Representative - Entry Level
Restaurant / Retail / Hospitality Experience Wanted - Entry Level Positions: Get Your Foot in the DoorAre you exhausted from the endless hours in a retail, restaurant or hospitality environment?Frustrated with the customers who think 15% is a GREAT TIP???Put down the J.O.B. Start a CAREER!We know that candidates in the restaurant, retail, and hospitality industries have valuable skill sets ...
Jul 19 -
Local Advertising Agency has multiple openings for customer service, marketing, and sales reps in our local office. We are looking for qualified applicants at all levels from entry level to experienced managers. -Full Time-No experience necessary- Must have people skills!-The opportunity to make up to $600-900/week, PAID WEEKLY-Must have reliable transportation.Use the title of the posting in ...
Jul 18 -
You have a gift. You know just what to say at any given moment. Your personality alone puts people at ease. People love you. People follow you. This is what drives you. This is the type of person we are looking for. Tired of giving up your social life from working nights and weekends? Do you want to sleep normal hours? Tired of working hard and not seeing opportunity? Have you finally ...
Line Cook
Job Location: Gibson Island, MarylandJOB DESCRIPTION The line cook is an integral and part of the culinary, food, and beverage team who will cook and prepare food to the chef's specifications, set-up and work on multiple stations with necessary supplies, stock inventory, follow recipes and plating standards, ensure food comes out simultaneously and to customer request, set up buffet food ...
Jul 15 -
Hotel Room Attendant
Position SummaryThe room attendant works under the direction of the Executive Housekeeper and the Assistant General Manager or General Manager. His or her responsibilities include following a daily schedule, performing proper cleaning of each guestroom, performing responsibilities outside the guestrooms, guest service & satisfaction, & individual effectiveness.Primary ResponsibilitiesLoad ...
Jul 15 -
Guest Service Representative
Position SummaryThe Guest Service Representative works under the direction of the Front Desk Supervisor and Front Office Manager. His or her responsibilities include daily checklist activities, performing various marking duties to generate additional revenue, providing optimum guest service and satisfaction.Primary ResponsibilitiesReconcile the cash drawer before & after shift by counting ...
Hospitality, call center, telemarketing, customer service, mortgage, financial,. Automotive, sales, training, auto, #autojobs, retail, customer service,....
Jul 19 - Baltimore, MD
Establish atmosphere in the office that promotes customer service and teamwork. As a leader in the hospitality and special event industry you can rest assured...
May 31 - Glen Burnie, MD
2+ years of customer service and sales experience. 1 or more years of experience in hospitality, retail, or food service industries (preferred)....
Jul 25 - Nottingham, MD
Jul 1 - Nottingham, MD
With its software, hardware, and portfolio of services, NCR enables nearly 550 million transactions daily across retail, financial, travel, hospitality, telecom...
Jul 15 - United States
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AMD designed its quad-core Opterons for multi-socket use from the start, with built-in HyperTransport links supporting up to eight sockets and 32 cores. Still, the company reckons small and medium-sized businesses may be perfectly happy with just one socket and four cores, which is why it has launched three Opteron 1300 series processors that deliver exactly that. These processors are based on the same "Barcelona" design as other quad-core Opterons.
The 1300 line includes the 2.1GHz Opteron 1352, the 2.2GHz Opteron 1354, and the 2.3GHz Opteron 1356. According to AMD's price list, the three chips cost $209, $255, and $377, respectively. AMD says the new single-socket Opterons will fit into "same socket and thermal requirements as previous AMD Opteron 1000 Series processors," which should mean they'll work with Socket AM2/AM2+ motherboards.
The world's biggest and third-biggest server makers have already decided to adopt the new chips. Dell will put them in its PowerEdge T105 server, while HP will stick them in both its ProLiant ML115 G5 server and xw4550 workstation. Not only that, but AMD says Cray has already begun shipping Opteron 1300-based XT4 supercomputers. Cray claims it builds its XT4 out of single-socket "processing elements" in order to avoid "the scheduling complexities and asymmetric performance problems associated with clusters of SMPs."
|2. chasp_0 - $251
|3. mbutrovich - $250
|4. Ryu Connor - $250
|5. YetAnotherGeek2 - $200
|6. aeassa - $175
|7. dashbarron - $150
|8. Captain Ned - $100
|9. Anonymous Gerbil - $100
|10. Bill Door - $100
This discussion is now closed.
|Asus brightens up its Z170 Pro Gaming mobo with Aura RGB LEDs
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|Seagate Nytro family now includes a 2TB M.2 SSD
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|Nvidia and AMD ease 360-degree video production with new APIs
|AMD FireRender is now the open-source Radeon ProRender
|AMD Radeon Pro graphics cards bring Polaris to content pros
|Radeon Pro Solid State Graphics keeps big data close to the GPU
|Pascal powers up pro graphics with Nvidia's new Quadros
|Now you can install Crysis directly on the video card!

subset: commoncrawl


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Harness the power of kinetic energy and light the room. This Hourglass Floor Lamp design by Danielle Trofe is a four foot tall LED lamp atop a rotating hourglass. Flip the lamp over and as the sands drop down, it powers the light. That makes it essentially a human powered lamp- which is part of the design- to put you more in touch with your energy usage. There's no details yet on availability, or how the power mechanism works, or how long the lamp lasts per flip. We do like the great modern design combined with eco-awareness. (via inhabitat)
Brightech - SKY LED Torchiere Floor Lamp - Dimmable Super Bright 30-Watt LED - Warm White Color - Omni-Directional Head - Sleek Black Finish


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Batman: Arkham Origins is due October 25, and it will have extra eye candy effects for GeForce owners. The game features a number of special effects powered by Nvidia's PhysX API. You can see some of them on display in the video below.
The PhysX-powered fog looks good, and it definitely fits the mood of the game. The soft shadows, particle-based snow effects, and tessellated footprints are also nice touches. I'm not getting much out of the PhysX-based cloth simulation used to animate Batman's cape, though. Nvidia's TXAA demo also falls flat, although that may be in part due to the YouTube video compression.
The video, which was posted by GamesHQMedia, is a perfect illustration of why YouTube can be a poor medium for showing off graphical effects in games. Even with the resolution cranked up to 720p, the footage looks dull and washed out. A lot of the textures lack detail, too, though video compression may not be the culprit there.
Arkham Origins should look better when rendered in real time, and I hope the PC version has higher-resolution textures than console versions of the game. It would be a shame if implementing vendor-specific effects took precedent over providing a crisper, more detailed world for all. Thanks to Rock, Paper, Shotgun for the tip.
This discussion is now closed.
|Samsung's Portable SSD T3 reviewed
|TR BBQ Day Shortbread
|Watch the "second-10th" TR BBQ live in 360 degrees right now
|G.Skill hooks up the TR BBQ with some giveaway goodies
|We threw a Minecraft party to test Samsung's Gear VR headset
|Deals of the week: cheap solid-state storage and more
|Sapphire Nitro+ Radeon RX 480 hot-rods Polaris 10
|AMD gets back in the black with its second-quarter financials
|Nvidia unveils a Pascal-powered Titan X with 11 TFLOPS on tap
|I'll...just review the thin air on my desk where a GTX 1060 would fit, since that's what we have.


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It's like a party in your mouth!
Greasy Moose
The world of Greasy Moose is filled with all sorts of odd characters.
Born and raised by cauliflower, Claveman is totally random!
fluid motion, funny, cool, clocks...clocks are weird. some are stupid and not funny some are funny. this one is funny. so yeah, nice movie.
just brilliant
Yes i love all of these shorts
crow clock, it seems you just appeard out of no where. i like the over all style of the movie. seemed vary pro.
nah, he's been around for awhile...
Great work fourchinnigan!
And thanks for inserting that blambot fonts place in the credits :)
Brilliant, but not funny.
Nah, it was funny. Your stuff is excellent and always clever. Keep up the great work!!


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Days Inn Hershey, Harrisburg - Hershey (and vicinity)
- Free continental breakfast, free WiFi, and free parking
Main amenities
- 101 smoke-free guestrooms
- Indoor pool
- Free airport shuttle
- 24-hour health club
- 24-hour business center
- 24-hour front desk
- Coffee/tea in a common area
- Air conditioning
- Daily housekeeping
- Arcade/game room
- Computer station
- Lobby fireplace
For families
- Rollaway/extra beds available
- Microwave
- Refrigerator
- Connecting/adjoining rooms available
- Private bathroom
- Premium TV channels
What's around
- Heart of Hershey
- Hershey's Chocolate World (1 mi / 1.6 km)
- Hersheypark Stadium (1.7 mi / 2.7 km)
- The Hershey Story Museum (0.3 mi / 0.6 km)
- Hershey Theatre (0.6 mi / 0.9 km)
- ZooAmerica (0.6 mi / 0.9 km)
Days Inn Hershey, Harrisburg - Hershey (and vicinity)
Hotel Info: 855-238-1590from $210
- Standard Room, 1 Queen Bed
- Business Room, 1 King Bed
- Standard Room, 2 Queen Beds, Accessible
- Standard Room, 1 Queen Bed, Accessible
- Standard Room, 2 Queen Beds
- Standard Room, 2 Queen Beds
- Room, 1 King Bed, Accessible
Also popular with travelers from the USA
At a glance
Key facts
Hotel size
- This hotel has 101 rooms
- This hotel is arranged over 4 floors
- Check-in time starts at 4 PM
- Check-out time is 11 AM
- Express check-in/out
Required at check in
- Credit card or cash deposit required
- Government-issued photo ID required
- Minimum check-in age is 21
Travelling with others
- Children (18 years old and younger) stay free when occupying the parent or guardian's room, using existing bedding
- Pets allowed (dogs only) *
- Specific rooms only *
- 2 per room (up to 50 lb)
Extra people
- Roll-away beds available, charges may apply*
- Free WiFi in public areas
- Free WiFi in rooms
- Free airport shuttle during limited hours *
- Free train station pickup *
- Free self parking
- Free theme park shuttle
Other information
- Smoke-free property
Nearby Two Star Harrisburg - Hershey (and vicinity) hotels
In the hotel
- Free continental breakfast daily
- Coffee/tea in a common area
- Indoor pool
- Fitness facilities
- Golfing nearby
- Kayaking nearby
- Arcade/game room
- 24-hour business center
- Business center
- Conference space size (feet) - 400
- Conference space size (meters) - 37
- One meeting room
- Computer station
- 24-hour front desk
- Concierge services
- Tours/ticket assistance
- Laundry facilities
- Free newspapers in lobby
- Multilingual staff
- Number of buildings/towers - 1
- Year Built 1989
- Elevator/lift
- Picnic area
- Fireplace in lobby
- Accessible bathroom
- In-room accessibility
In the room
- Air conditioning
- Coffee/tea maker
- Iron/ironing board
- Premium bedding
- Pillowtop mattress
- Private bathroom
- Shower/tub combination
- Free toiletries
- Hair dryer
- 37-inch flat-screen TV
- Premium TV channels
- Desk
- Free weekday newspaper
- Free WiFi
- Free local calls
- Refrigerator
- Microwave
- Daily housekeeping
- In-room safe (laptop compatible)
- Connecting/adjoining rooms available
Top Harrisburg - Hershey (and vicinity) hotels
Recently reviewed hotels in Harrisburg - Hershey (and vicinity)
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Nearby hotels
Days Inn Hershey, Harrisburg - Hershey (and vicinity)'s small print
Also known as
- Days Inn Hershey
- Days Inn Hotel Hershey
- Hershey Days Inn
- Days Inn Hershey Hotel Hershey
- Days Inn Hershey Hotel
The property has connecting/adjoining rooms, which are subject to availability and can be requested by contacting the property using the number on the booking confirmation.
Pet-friendly rooms can be requested by contacting the property at the number on the booking confirmation.
Guests under 16 years old are not allowed in the fitness facility.
For transfers, guests must contact the property before arrival at the number on the booking confirmation.
Mandatory fees
You'll be asked to pay the following charges at check in or check out:
- Resort fee: USD 1.59 per accommodation, per night
Optional extras
Rollaway beds are available for USD 10.00 per night
Safes in guestrooms can be used for USD 1.59 per night
Pets are allowed for an extra charge of USD 15 per pet, per night
We have included all charges provided to us by this hotel. However, charges can vary, for example, based on length of stay or the room you book.
Is the description of this hotel not correct? Tell us


text: Home > Entertainment Young actor snubs Aiko Melendez ABS-CBN News Posted at Aug 04 2014 12:43 PM | Updated as of Aug 04 2014 08:43 PM Share Facebook Twitter GPlus LinkedIn Pinterest Aiko Melendez. File Photo MANILA – Aiko Melendez believes some young stars of this generation do not know how to give respect to showbiz veterans like her. Melendez, who has been in showbiz for three decades now, said she she experienced this herself when a young actor just stared at her after she introduced herself to him. In an interview with MJ Felipe and Ambet Nabus on DZMM on Sunday, Melendez shared: "Ako kasi for a time, 'di ba I was away when I was in politics, so hindi talaga ako updated sa mga baguhang artista. Hindi ko sila kilala. So ako, my way of reaching out is when I see them, I smile at them hoping that I get a smile back and introduce myself." "There was this one time, I was just smiling dito sa bagets na artistang ito. So sabi ko sa kanya 'Hi, I'm Aiko Melendez.' Tapos wala lang, tinignan lang niya ako. So sabi ko parang, ay okay," she added. While refusing to name the young star, Melendez said the incident happened while she was at the ABS-CBN compound. Asked if she has any message to the young actor, Melendez said: "Pinagdasal ko na lang 'yan. Actually ang prayer ko nga for that guy… basta the bigger star you are, dapat mas humble ka kasi God will bless you more." The actress-politician reminded showbiz newcomers that they are only good as their last projects. Share Facebook Share on Twitter GPlus LinkedIn Pinterest Read More: Aiko Melendez /sports/07/30/16/mickelson-makes-cut-despite-horror-start-mcilroy-misses-it/sports/07/30/16/weightlifting-russian-weightlifters-barred-from-rio-games/sports/07/30/16/monfils-beats-raonic-in-toronto-djokovic-wins/sports/07/30/16/rio-security-screeners-fired-one-week-before-games/entertainment/v2/07/30/16/look-celebrities-who-soared-highest-in-sexiest-list


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The global generic pharmaceuticals market is likely to witness strong growth in the next few years owing to the patent expiration of key blockbuster drugs and the judicious cost containment efforts…
Source: PATENT EXPIRY DATES
The global generic pharmaceuticals market is likely to witness strong growth in the next few years owing to the patent expiration of key blockbuster drugs and the judicious cost containment efforts…
Source: PATENT EXPIRY DATES
Posted in Uncategorized | Leave a Comment »
Reporter: Aviva Lev-Ari, PhD, RN
During his 2016 State of the Union address, President Barack Obama called on Vice President Joe Biden – who had months earlier lost his son Beau to brain cancer – to head a "moonshot" to significantly accelerate research into the disease. The president said he wanted to harness the spirit of American innovation that took us from zero to landing a man on the moon in a decade to similarly find new ways to prevent, diagnose and treat cancer.
One of those intrigued by that call to action was Stanford's Jan Liphardt, an associate professor of bioengineering who specializes in biophysics, the tumor microenvironment and data analysis. Stanford Engineering talked to Liphardt about how he came to be involved with the moonshot and his approach to using data and the voice of patients to better understand cancer and how it can be treated, and how sharing information can better inform the course of cancer research.
How did you get involved in the National Cancer Moonshot?
In March, after the president's charge, the vice president challenged scientists, doctors, industry and patients to give their best ideas to the moonshot. The White House also reached out to a few outsiders, myself included. The White House instructions were unusual: "Do something big and different. There is no money and you have 87 days. Go."
I like a challenge, and this was a chance to serve, even in the face of administrative hurdles. So I looked for advice, teammates and support. Russ Altman, a colleague at Stanford, suggested it was time to give patients a way to volunteer their own health data in order to help find cures. I collaborated with Peter Kuhn, a professor of medicine and engineering at the University of Southern California, who's known for carefully listening to cancer patients, advocates and their supporters. In short order we had links with advocates like AnneMarie Ciccarella, Sonja Durham, Lori Marx-Rubiner, Jack Whelan and Jack Park. That's how we got to CancerBase.org.
What's the idea the team came up with?
We thought for about a week: What would matter to the patients that Stanford and other research institutions serve? What would scale? Well, we're not going to run a clinical trial, go near protected health information, invent a new drug or write a research proposal. There's no time for that. Whatever it was, it had to be useful, scalable, legal and different. That pointed to data, the web, patients and decisions.
One thing jumped out: Right now, there's significant friction in medical data sharing. People all over the world can already effortlessly share other kinds of information – pictures, movies, ideas, stories, tweets. Increasingly, they are using the same tools to share personal medical information. It's remarkable what cancer patients already share: diagnoses, genomes, pathology images. But that information is not yet widely used to understand where they are with their diseases.
Ideally, everyone, including scientists and doctors, would have as much information as possible at their fingertips. Many patients think when they give data for research, magically scientists all over the world can dig into this information, find patterns and help. The practical reality is that it's nearly impossible for any one scientist to access the amounts of data they would like.
So that's the simple idea: A global map and give patients the tools they need to share their data – if they want to. They can donate information for the greater good. In return, we make a simple promise: When you post data, we'll anonymize them and make them available to anyone on Earth in one second. We plan to display this information like real-time traffic data. HIPAA doesn't apply to this direct data-sharing. The patients can give us whatever information they want, and they can tell us what they want us to do with it. We're a conduit. Their data belong to them, not to us.
How does it work?
Today we ask just five basic questions. Over time we will add more. You join, give some information, and we'll put you on a global map. Right now, some of the things we don't know about cancer are incredibly simple: Where is everyone on Earth with cancer? How old are they? What is their diagnosis? Did their cancers metastasize? Global, instantaneous data sharing is the story.
In a second phase, we are going to see if we can plot all the information just like Waze does for traffic. Our role is to synthesize the information and plot it in ways that ordinary people can understand. Think of it this way – patients want to be able to chart their treatment path. Who went straight, who went left? People just getting on the highway are curious about what people did who came before them, and what happened to those people. Did they arrive at the destination easily and promptly? We're a real-time diagnosis and therapy mapping service for cancer.
You say that giving patients a way to share their health data is important to help finding cures. Why?
Let me give you a specific example. At Stanford, I'm part of a team of cancer biologists and clinicians funded by the Stanford Cancer Institute to think about the next generation of screening for breast cancer in the U.S. Every year, the U.S. uses mammography to screen more than 40 million women for breast cancer. In this project, it quickly became clear that there is currently no central, easy-to-access repository of mammograms for research use.
That's a major lost opportunity – our nation spends billions on screening, but we don't store, share and analyze this information in a scalable and simple manner. In the traditional approach, our team would spend several hundred thousand dollars, and about three years, to assemble perhaps 1,000 mammograms. We would then use this tiny dataset to try to find something interesting, but since the dataset is so small, we would be blind to rare features of breast cancer and its predictors. It clearly makes a lot more sense to compare and explore 100 million images.
This sounds completely impossible until you realize that Instagram users upload 58 million images every day. Once you start to think about supposedly intractable research problems from a web or social networking perspective, new possibilities open. Imagine, for example, if there were a simple way for every single woman on Earth to upload and share her de-identified mammogram? Or more generally, imagine a world in which patients have the tools to globally share de-identified health data, if they want to. That's exactly the idea behind CancerBase – let's just give people those tools and see what happens.
How much data and how many people are needed to make this viable?
We think we are going to need several tens-of-thousands of members. There are approximately 50 million people on Earth with a cancer diagnosed in the last five years, and 200 million more people have an immediate family member with cancer. Almost 2 billion people are active on Twitter and Facebook – a quarter of the world's population. If just a few percent of those people sign up, we could do something no one on Earth has done before.
Are there hopes to create a "developer community," people who find ways to use your data that you didn't even think about or have the time to work on?
Definitely. As much as we think we can predict what these data are useful for, we don't really know. By making the anonymized data available to everyone within one second, they might start to do things that we never dreamed of. The more eyes look at these data, the better off everyone will be. The dream is to have cancer-relevant medical data flow unimpeded around the world in seconds, so that everyone, wherever they are, can see and use this information.
Posted in CANCER BIOLOGY & Innovations in Cancer Therapy, Computational Biology/Systems and Bioinformatics, Genetics & Innovations in Treatment, Genetics & Pharmaceutical, Genome Biology, Imaging-based Cancer Patient Management | Leave a Comment »
Reporter: Aviva Lev-Ari, PhD, RN
Researchers develop rapid screening technique; find gene defends tumors from DNA damage
WDR5 emerges as robust "hit"
WD repeat-containing protein 5 (WDR5), a core part of the COMPASS complex regulating chromatin function, was implicated in multiple screens. Recent research by others had shown WDR5 to be upregulated in prostate and bladder cancers and critical for cancer cell proliferation.
The team confirmed WDR5 was highly expressed in pancreatic cancer compared to normal pancreas tissue and then conducted a series of experiments which showed knocking down the gene impaired cell proliferation and tumor growth and greatly increased survival in mice.
Subsequent experiments showed WDR5 works in concert with Myc to protect pancreatic cancer from DNA damage. There is no known method for targeting either WDR5 or Myc separately, Carugo said, but the team thinks there might be ways to block their interaction.
While the team targeted epigenetic regulators, Carugo noted the technique can be used with other shRNA libraries aimed at different classes of genes.
This technology is being widely adopted by MD Anderson's moon shot teams to identify genetic vulnerabilities and cancer targets specific to various disease subtypes.
Story Source:
The above post is reprinted from materials provided by University of Texas M. D. Anderson Cancer Center. Note: Materials may be edited for content and length.
Alessandro Carugo et al. In Vivo Functional Platform Targeting Patient-Derived Xenografts Identifies WDR5-Myc Association as a Critical Determinant of Pancreatic Cancer. Cell Reports, June 2016 DOI:10.1016/j.celrep.2016.05.063
Current treatment regimens for pancreatic ductal adenocarcinoma (PDAC) yield poor 5-year survival, emphasizing the critical need to identify druggable targets essential for PDAC maintenance. We developed an unbiased and in vivo target discovery approach to identify molecular vulnerabilities in low-passage and patient-derived PDAC xenografts or genetically engineered mouse model-derived allografts. Focusing on epigenetic regulators, we identified WDR5, a core member of the COMPASS histone H3 Lys4 (H3K4) MLL (1-4) methyltransferase complex, as a top tumor maintenance hit required across multiple human and mouse tumors. Mechanistically, WDR5 functions to sustain proper execution of DNA replication in PDAC cells, as previously suggested by replication stress studies involving MLL1, and c-Myc, also found to interact with WDR5. We indeed demonstrate that interaction with c-Myc is critical for this function. By showing that ATR inhibition mimicked the effects of WDR5 suppression, these data provide rationale to test ATR and WDR5 inhibitors for activity in this disease.
Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.
Posted in CANCER BIOLOGY & Innovations in Cancer Therapy, Cancer Screening, Chemical Genetics, Computational Biology/Systems and Bioinformatics | Tagged COMPASS complex regulating chromatin function, WD repeat-containing protein 5 (WDR5), WDR5 critical for cancer cell proliferation, WDR5 to be upregulated in prostate and bladder cancers | Leave a Comment »
Part 1 (of a two-part conference) will cover the use of CRISPR/Cas9 and RNAi for identifying new drug targets and therapies. It will bring together experts from all aspects of basic science and clinical research to talk about how and where gene editing and RNAi can be best applied. What are the different tools that can be used and what are their strengths and limitations? How does the CRISPR/Cas system compare to RNAi and other gene editing tools, such as Transcription Activator-like Effector Nucleases (TALENs) and zinc finger nucleases (ZFNs), and do they have any complementary uses? Scientists and clinicians from pharma/biotech as well as from academic and government labs will share their experiences leveraging the utility of gene editing for target discovery, disease modeling, and for creating cell and viral therapies. Learn more atDiscoveryOnTarget.com/RNAi-screens-functional-genomics
Keynote Session: Genome Editing for In Vivo Applications
AAV for Gene Therapy and Genome Editing
Using CRISPR/Cas to Target and Destroy Viral DNA Genomes
Targeted Endonucleases as Antiviral Agents: Promises and Pitfalls
Nucleic Acid Delivery Systems for RNA Therapy and Gene Editing
PANEL DISCUSSION: CRISPR/Cas: A Realistic and Practical Look at What the Future Could Hold
About the Conference
Cambridge Healthtech Institute's 13th annual two-part conference on Advances in Gene Editing and Gene Silencing will cover the latest in the use of CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats)/Cas9-based gene editing and RNA interference (RNAi) for use in drug discovery and for developing novel drug therapies.
For sponsorship and exhibit sales information including podium presentation opportunities, contact:
Recommended All Access Package:
September 19 Symposium:
September 20-21 Conference:
September 21-22 Conference:
Posted in CRISPR/Cas9 & Gene Editing, Gene Regulation, Genome Biology, Uncategorized | Tagged @CHI, adenovirus, Boston, CRISPR-based gene editing, gene editing, James Wilson | Leave a Comment »
Reporter: Aviva Lev-Ari, PhD, RN
The therapeutic potential of miRNA (miR) in cancer is limited by the lack of efficient delivery vehicles. Here, we show that a self-assembled dual-colour RNA-triple-helix structure comprising two miRNAs—a miR mimic (tumour suppressor miRNA) and an antagomiR (oncomiR inhibitor)—provides outstanding capability to synergistically abrogate tumours. Conjugation of RNA triple helices to dendrimers allows the formation of stable triplex nanoparticles, which form an RNA-triple-helix adhesive scaffold upon interaction with dextran aldehyde, the latter able to chemically interact and adhere to natural tissue amines in the tumour. We also show that the self-assembled RNA-triple-helix conjugates remain functional in vitro and in vivo, and that they lead to nearly 90% levels of tumour shrinkage two weeks post-gel implantation in a triple-negative breast cancer mouse model. Our findings suggest that the RNA-triple-helix hydrogels can be used as an efficient anticancer platform to locally modulate the expression of endogenous miRs in cancer.
In mice, device destroyed colorectal tumors and prevented remission after surgery.
Helen Knight | MIT News Office
July 25, 2016
Approximately one in 20 people will develop colorectal cancer in their lifetime, making it the third-most prevalent form of the disease in the U.S. In Europe, it is the second-most common form of cancer.
The most widely used first line of treatment is surgery, but this can result in incomplete removal of the tumor. Cancer cells can be left behind, potentially leading to recurrence and increased risk of metastasis. Indeed, while many patients remain cancer-free for months or even years after surgery, tumors are known to recur in up to 50 percent of cases.
Conventional therapies used to prevent tumors recurring after surgery do not sufficiently differentiate between healthy and cancerous cells, leading to serious side effects.
In a paper published today in the journal Nature Materials, researchers at MIT describe an adhesive patch that can stick to the tumor site, either before or after surgery, to deliver a triple-combination of drug, gene, and photo (light-based) therapy.
Releasing this triple combination therapy locally, at the tumor site, may increase the efficacy of the treatment, according to Natalie Artzi, a principal research scientist at MIT's Institute for Medical Engineering and Science (IMES) and an assistant professor of medicine at Brigham and Women's Hospital, who led the research.
The general approach to cancer treatment today is the use of systemic, or whole-body, therapies such as chemotherapy drugs. But the lack of specificity of anticancer drugs means they produce undesired side effects when systemically administered.
What's more, only a small portion of the drug reaches the tumor site itself, meaning the primary tumor is not treated as effectively as it should be.
Indeed, recent research in mice has found that only 0.7 percent of nanoparticles administered systemically actually found their way to the target tumor.
"This means that we are treating both the source of the cancer — the tumor — and the metastases resulting from that source, in a suboptimal manner," Artzi says. "That is what prompted us to think a little bit differently, to look at how we can leverage advancements in materials science, and in particular nanotechnology, to treat the primary tumor in a local and sustained manner."
The researchers have developed a triple-therapy hydrogel patch, which can be used to treat tumors locally. This is particularly effective as it can treat not only the tumor itself but any cells left at the site after surgery, preventing the cancer from recurring or metastasizing in the future.
Firstly, the patch contains gold nanorods, which heat up when near-infrared radiation is applied to the local area. This is used to thermally ablate, or destroy, the tumor.
These nanorods are also equipped with a chemotherapy drug, which is released when they are heated, to target the tumor and its surrounding cells.
Finally, gold nanospheres that do not heat up in response to the near-infrared radiation are used to deliver RNA, or gene therapy to the site, in order to silence an important oncogene in colorectal cancer. Oncogenes are genes that can cause healthy cells to transform into tumor cells.
The researchers envision that a clinician could remove the tumor, and then apply the patch to the inner surface of the colon, to ensure that no cells that are likely to cause cancer recurrence remain at the site. As the patch degrades, it will gradually release the various therapies.
The patch can also serve as a neoadjuvant, a therapy designed to shrink tumors prior to their resection, Artzi says.
When the researchers tested the treatment in mice, they found that in 40 percent of cases where the patch was not applied after tumor removal, the cancer returned.
But when the patch was applied after surgery, the treatment resulted in complete remission.
Indeed, even when the tumor was not removed, the triple-combination therapy alone was enough to destroy it.
The technology is an extraordinary and unprecedented synergy of three concurrent modalities of treatment, according to Mauro Ferrari, president and CEO of the Houston Methodist Research Institute, who was not involved in the research.
"What is particularly intriguing is that by delivering the treatment locally, multimodal therapy may be better than systemic therapy, at least in certain clinical situations," Ferrari says.
Unlike existing colorectal cancer surgery, this treatment can also be applied in a minimally invasive manner. In the next phase of their work, the researchers hope to move to experiments in larger models, in order to use colonoscopy equipment not only for cancer diagnosis but also to inject the patch to the site of a tumor, when detected.
"This administration modality would enable, at least in early-stage cancer patients, the avoidance of open field surgery and colon resection," Artzi says. "Local application of the triple therapy could thus improve patients' quality of life and therapeutic outcome."
Artzi is joined on the paper by João Conde, Nuria Oliva, and Yi Zhang, of IMES. Conde is also at Queen Mary University in London.
The Development of siRNA-Based Therapies for Cancer
Author: Ziv Raviv, PhD
Targeted Liposome Based Delivery System to Present HLA Class I Antigens to Tumor Cells: Two papers
Reporter: Stephen J. Williams, Ph.D.
Blast Crisis in Myeloid Leukemia and the Activation of a microRNA-editing Enzyme called ADAR1
Curator: Larry H. Bernstein, MD, FCAP
First challenge to make use of the new NCI Cloud Pilots – Somatic Mutation Challenge – RNA: Best algorithms for detecting all of the abnormal RNA molecules in a cancer cell
Reporter: Aviva Lev-Ari, PhD, RN
miRNA Therapeutic Promise
Curator: Larry H. Bernstein, MD, FCAP
Posted in 3D Plotting Scaffolds, Advanced Drug Manufacturing Technology, Biopolymer Blend Open Porous, Cancer and Therapeutics, CANCER BIOLOGY & Innovations in Cancer Therapy, Cancer Informatics, Cell Level, Computational Biology/Systems and Bioinformatics, Drug Delivery Platform Technology, Drug Development using MultiOrgan Chip, Drug Development/Formulation using 3D Printing, Genomic Expression, loss of function gene, MicroEngineering Cell-Tissue & Systems, Nanotechnology for Drug Delivery | Tagged a miR mimic (tumour suppressor miRNA), antagomiR (oncomiR inhibitor), anticancer platform to locally modulate the expression of endogenous miRs in cancer, Conjugation of RNA triple helices to dendrimers, natural tissue amines in the tumour, post-gel implantation, RNA-triple-helix adhesive scaffold upon interaction with dextran aldehyde, RNA-triple-helix hydrogels, self-assembled dual-colour RNA-triple-helix structure, self-assembled RNA-triple-helix conjugates remain functional in vitro and in vivo, therapeutic potential of miRNA (miR) in cancer, triplex nanoparticles | Leave a Comment »
Reporter: Stephen J. Williams, Ph.D.
July 26, 2016 (Philadelphia, PA)
A Round Table and Q&A with the Entrepreneur Group Business Forward and John Podesta,Chairman and Founder of Center for American Progress on Policy, Economic Growth and Opportunity
With the help of more than 50 of the world's most respected companies, Business Forward is making it easier for tens of thousands of business leaders from across America to advise Washington on how to create jobs and accelerate our economy. Business Forward is active in over 100 cities and works with more than 450 senior Administration officials, Members of Congress, mayors, and governors.
Business leaders who have participated in our briefings have seen their suggestions implemented in the Affordable Care Act, the Jobs Act, three trade agreements, and every one of the President's budgets. Many have also shared their recommendations with their representatives in Congress and through op-eds and interviews with local media. Ninety-eight out of 100 business leaders who have participated in a Business Forward briefing would be interested in participating in another one.
Many of America's largest and most respected firms – from America's software, telecommunications, media, hospitality, financial services, manufacturing, apparel, defense and pharmaceutical industries – have already joined Business Forward.
Members include Aetna, American Airlines, AT&T, Comcast, Cheniere Energy, Deloitte, Dow, eBay Inc., Fidelity Investments, Facebook, Ford, Google, Intuit, Lockheed Martin, Microsoft, the National Restaurant Association, Pacific Gas & Electric, POET, Pricewaterhouse Cooper, Qualcomm, SAS, T-Mobile, Time Warner, Time Warner Cable, Verizon, Viacom, Visa, and Walmart.
These corporations work with Business Forward to identify, recruit and brief small business owners, venture capitalists and entrepreneurs of all kinds who are looking for a meaningful way to participate in policy debates.
John Podesta delivered opening remarks at the launch event for the Washington Center for Equitable Growth on November 15, 2013.
Recommendations to Advance Progressive Change
John Padesta (JP): We have had an economic bounce back from the recession however it is agreed that wages need to go up in US. The goal of policy is to return to a more equitable time such as during the 90's. The Hillary Clinton campaign is actively reaching out to find out what is happening on all levels of the economy: from small startups to international trade and workers views.
JP: There are five main areas the Clinton campaign is focusing on with regard to economic growth policy
JP: want to get entrepreneurs more involved with policy decision. Clear directive from Hillary is that policy requires input from ALL stakeholders in economy in all sectors
There may be a focus on paid leave
Question from audience: What about the crisis in rural health.
Definitely a problem Ann O'Leary will be heading up the health policy for Clinton campaign
Posted in Health Economics and Outcomes Research, Venture Capital | Tagged Biotech Investment and Venture Growth: The Franchising of Intellectual Property as a Business Model, economic policy | Leave a Comment »
Curator: Aviva Lev-Ari, PhD, RN
Understanding CRISPR: Mechanisms and Applications: CHI, September 19-22, 2016, Westin Boston Waterfront, Boston
Announcement from LPBI Group: key code LPBI16 for Exclusive Discount to attend Boston's Discovery on Target (September 19-22, 2016, CRISPR: Mechanisms to Applications on 9/19/2016)
The emergence of Gene Editing: CRISPR Science and Technology provide evidence that since the NIH effort to sequence the Genome, this endeavor is the second one to follow as an evolving scientific community ecosystem at their best in COMPETITION AND COLLABORATION, as well as in the survival of the fittest struggle that yielded a legal battle on appropriation of the discovery and the rights to its Intellectual Property (IP).
On our Journal we published
See references in
UPDATED – Status "Interference — Initial memorandum" – CRISPR/Cas9 – The Biotech Patent Fight of the Century
Reporter: Aviva Lev-Ari, PhD, RN
From nature.com
From elsewhere
The soaring popularity of gene editing has made celebrities of the principal investigators who pioneered the field — but their graduate students and postdocs are often overlooked.
Doudna and other principal investigators involved in the seminal work have become scientific celebrities: they are profiled in major newspapers, star in documentaries and are rumoured to be contenders for a Nobel prize. "When I came to the lab, I was the only person studying CRISPR," Wiedenheft says. "When I left the lab, almost everyone was studying it."
His work with Doudna yielded a First author place on their 2011 Nature article:
Nature 477, 486–489 (2011).et al.
In January 2016, Eric Lander, president of the Broad Institute of MIT and Harvard in Cambridge, Massachusetts, tossed into this minefield a historical portrait called 'The Heroes of CRISPR
Cell 164, 18–28 (2016).
Editor of Cell received letters questioning the decision to publish Eric Lander's article due to Broad Institute involvement in a legal dispute and presenting an incomplete picture of the evolution of the discovery and using a title that assigns the Heroism on a matter legally unsettled.
Does the Cell, 2016 article present all attributions due to:
The microbiologist spent years moving labs and relishing solitude. Then her work on gene-editing thrust her into the scientific spotlight.
27 April 2016
Unusual battle among academic institutions holds key to gene-editing tool's future use.
credit in science goes to the Leader of the lab, as do any prizes that follow.
Posted in Computational Biology/Systems and Bioinformatics, CRISPR/Cas9 & Gene Editing, Genome Biology, Personalized and Precision Medicine & Genomic Research, Scientist: Career considerations | Leave a Comment »


text: Steve Martin's Overachieving Letterman PerformanceRyan Tate2/03/09 6:48amFiled to: Celebrity scienceSteve MartinDavid Lettermanlate showClipsTop722EditInvite manuallyPromoteDismissUndismissHideShare to KinjaToggle Conversation toolsGo to permalinkSince it's not enough that he's a New Yorker contributor, perennial SNL and Oscars host, movie star and chart-topping banjo player, Steve Martin had to be awesome on David Letterman last night.Let's recap renaissance man Martin's Late Show appearance: he starred in a specially-produced pre-recorded skit involving Flight 1549; he told a story about how he rules at online poker while on drugs (another skill!); chatted humorously about myriad other topics and then played banjo, well, with his bluegrass band. On behalf of all other late-night guests who have to follow in Martin's footsteps: Screw you, nerd. Host's pet, you are. Advertisement Video excerpt up top.Reply72 repliesLeave a reply


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Top Definition
The act of intentionally hesitating while making a decision.
hesitention; hesitentional
hesitention; hesitentional
You know that girl in front of us at Starbucks? She hesitentionally ordered her coffee; doesn't she realize people are in a hurry?
viết bởi Sean H. Murphy 03 Tháng mười một, 2006
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Sovereign citizens: Is this an accurate portrayal?
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Look, this is all just as made up as all the other bullshit. Law this, law that, there is no law, with things like the NDAA, drones, hollow points, assassinations, there is no law. You are hiding yourself behind a paper tiger, something that is just as much an illusion as their system.
Tyranny is tyranny, you cannot contract with anyone who has never signed anything, or willingly entered said contract.
You can not scream, yell, and preach to a nation that has been brainwashed from birth, and expect them to sit down and study some legal tripe that is just as complicated and just as idiotic as the system they just woke up from. People are sick of being robbed, stolen, and enslaved.
You did say that God is who bestows your freedoms upon you, that is the short and simple truth, and if anyone tries to steal those freedoms, it is Tyranny, and therefore should be dealt with accordingly.
Anonymous Coward 34319433
Well, not all of us are asleep, I do agree their "laws" are not much more than magic spells, they do have power over those who believe they have power and do not know how to use their spells against them and expose them as men behind curtains.
In reality, nothing will stop them so long as violence is our only solution, we cannot be "free" collectively in ignorance. But we can exhaust all options personally before we end up in a cabin with SWAT teams deploying "burners".
How you choose to counter (or play along with) them is YOUR choice and in the end, that is the only proof I need that we do have power and rights over them.
Anonymous Coward 31297288
Stop paying your taxes and you'll end up like this guy.
This is not an illusion, i guess you can believe what you want until the end of your life here on earth.
Thread: Blast from the Past - Government is your Friend 1983
Anonymous Coward 32235185
Stop paying taxes?
what taxes are you talking about? While I do not pay income tax, I pay taxes all the time.
Not in prison either, I guess that guys reality is reality for everyone else? You do realize that statistically nearly no one goes to prison for income tax charges, right?
The fear mongering about going to prison for income taxes is kind of silly when you actually look at the stats.
But, hey, fear is more fun, right?
The IRS boogie man!!!! RUN!!!
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13 Important Elements To Look For In Every Staged Shooting Event
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@casetify turns your Instagrams into cool iPad Cases. Great gift ideas
1953 Dannenhauer & Stauss. It is based on a Volkswagen Beetle. Only very few (around 16) of ~100 Cabriolets have survived until today. - http://www.classicvws.com/othertypes.htm - http://www.powerful-cars.com/php/vw/1951-dannenhauer-stauss-cabriolet.php
Julie Ann Art | Renegade Craft Fair
Eliza Gran Pom Pom Basket - Medium// see how expensive this is? you can make it yourself with a much cheaper basket and diy Pom poms!!
Leandro Erlich In one of the 21st Century Museum of Art (Kanazawa, Japan) courtyards is a swimming pool framed by a limestone deck. When seen from the deck, the pool appears to be filled with deep, shimmering water. In fact, however, a layer of water only some 10 centimeters deep is suspended over transparent glass. Below the glass is an empty space with aquamarine walls that viewers can enter.
Offensive Business Cards
Balding post-its.. haha!
http://www.pinterest.com/cariboucoffee/the-coffee-created-on-pinterest/ Inspiration. CaribouInspires.com
Cary Grant and Katharine Hepburn on set of "The Philadelphia Story"
Reba Stewart. Driftwood Mobile. 1962
Ferm Living's Animal Hooks


text:
List all words starting with osmiums
Only the word osmiums was found, nothing longer.
Some random words: gnar if kea no do okra reopen
This is not a dictionary, it's a word game wordfinder.
- Help and FAQ - Examples - Home
Privacy and Cookies Policy - Share - © Copyright 2004-2016 Morewords.com - 5.029mS


text:
Columbus Bobb Chevrolet
4639 W Broad StColumbus, OH 43228
2. Bobb Pre Owned Super Store
4639 W Broad St.,Columbus, OH 43228
3. Bobb Suzuki
4639 W Broad StColumbus, OH 43228
4. Bobb Auto RepairServices
4639 W Broad St Ste 200Columbus, OH 43228
5. Jack Maxton ChevroletServices
700 E Dublin Granville RdColumbus, OH 43229
From Business: Jack Maxton Chevrolet is an automobile dealership that offers new and pre-owned vehicles from Chevrolet. Jack Maxton Chevrolet operates a service department that of…
6. Dave Gill Chevrolet
4700 E Broad StColumbus, OH 43213
7. Dan Tobin Chevrolet Buick GMCProducts
Have purchased 2 new cars and 1 used car from Dan Tobin. Always fair and honest. Service guys are great and they are open until midnight! Works g…
8. Jeff Wyler Chevrolet Inc
We bought a new Chevy Cobalt in January from McDorman. There was little to no hassle from sales and they really worked with us on getting a good de…
9. Jack Maxton Chevrolet - North High
I was looking for a vehicle in a specific price range. Additionally, I was looking for something with a little bit of muscle, lower miles and a dec…
10. Jack Maxton Chevrolet
1516 Harrisburg PikeColumbus, OH 43223
11. Jack Maxton Chevrolet IncServices
6601 Huntley Rd Ste BColumbus, OH 43229
12. Byers Chevrolet - CLOSED
I bought a used car for over $7,000, two weeks later I got stranded in Kentucky when the care broke down. I had to spend over $800 to get it fixed a…
13. Byers Chevrolet - CLOSED
555 W Broad StColumbus, OH 43215
From Business: Byers Automotive has been a family-owned and operated automobile dealership since 1897. The dealership offers new and pre-owned vehicles of various makes, such as A…
14. Hanes Chevrolet Co
PO Box 297South Webster, OH 45682
15. Jeff Wyler Chevrolet of Columbus
5885 Gender RoadCanal Winchester, OH 43110
From Business: Jeff Wyler Chevrolet of Columbus is your premiere Chevrolet dealer. Formerly Bob McDorman Chevrolet, Jeff Wyler Chevrolet of Columbus sells new Chevy cars, trucks, …
16. Chevrolet Of Dublin
5016 Post RdDublin, OH 43017
17. Byers Chevrolet
5887 N Meadows DrGrove City, OH 43123
18. Jack Maxton Chevrolet Inc
8625 Columbus PikeLewis Center, OH 43035
19. Bob Mc Dorman Chevrolet Inc
5885 Gender RdCanal Winchester, OH 43110
20. Chesrown Chevrolet Buick GMC
1701 Columbus PikeDelaware, OH 43015
From Business: Chesrown Chevrolet Buick GMC, located at 1701 Columbus Pike, is a Chevrolet, Buick and GMC dealership, as well as a full GM service center. Chesrown Chevrolet Buick…
21. Chesrown Chevrolet Buick Gmc, Inc.
I had an incredible experience with this Dealership. They were very forward in giving me all the relevant information upfront when I purchased my 2…
22. Coughlin Chevrolet of Pataskala
9000 E Broad StPataskala, OH 43062
23. Chesrown Chevrolet Buick GMC
1701 Columbus PikeDelaware, OH 43015
24. Lash ChevroletProducts
I've bought Chevrolets and had them serviced at this dealership for many years, even under previous owners. Their staff is nothing but gracious and …
25. Lash Chevrolet
US Rte 62Johnstown, OH 43031
From Business: A Letter From The Owner... Over the years, this dealership has always been committed to taking care of customers. Though the ownership and name have changed, you ca…
26. Coughlin Chevrolet-Buick-Cad
15801 US Highway 36Marysville, OH 43040
From Business: Roby Auto Group is a full-service automobile dealership that provides a range of vehicles from Chevrolet, Pontiac and Buick. It also offers pre-owned vehicles from …
27. Dave Kehl Chevrolet
38 E Sandusky StMechanicsburg, OH 43044
From Business: Dave Kehl Chevrolet is a Chevrolet dealership located at 38 E. Sandusky Street. You can find GM parts, Chevy repair services, and new and used vehicles at this Mech…
28. Harden Chevrolet
324 W Main StCircleville, OH 43113
29. Dave Kehl Chevrolet, Inc.Products
45-47 E SanduskyMechanicsburg, OH 43044
From Business: We're the new General Motors. We are a company of diverse brands, selling over 7.5 million vehicles in over 120 countries worldwide. We're well positioned to take p…
30. Roby Auto Group Chevrolet Oldsmobile Pontiac & - CLOSED
15801 US Highway 36Marysville, OH 43040
From Business: The home of Chevrolet, Pontiac and Buick.....We are a big part of the local community. We have a strong and committed sales staff with many years of experience sati…


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Foursquare © 2016 Lovingly made in NYC & SF
The Depot Grill
Sandwiches · $
613 W Maumee St
"Really fresh, locally-sourced burgers and sandwiches at this recently opened grill on the campus of Trine University. Prices are a bit steep, but you're paying for quality, never-frozen food. Yummy!"
Great Lakes Chocolate & Coffee Co.
Coffee Shop · $
N Wayne Street (Calvary Lane)
"The frozen mochas and white chocolate raspberry lattes are awesome! So are the cinnamon rolls!"
Ruby Tuesday
American · $$
2304 N Wayne St
"The homemade guacamole takes a little longer, but it was worth the wait...and I'm not an easy please"
Trine University Campus
Created by Trine University Storm38 items • 10 followers
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Moody's to review H.B., Santa Ana
SACRAMENTO One of the nation's top credit rating agencies announced Tuesday that it will review 30 California cities – including Huntington Beach and Santa Ana – for possible downgrades amid mounting concern over municipal bankruptcies and bond defaults.
"California cities operate under more rigid revenue raising constraints than cities in many other parts of the country," said Eric Hoffmann, who heads Moody's California local government ratings team. "Combined with steeply rising costs, these constraints mean that these cities will likely recover more slowly than their peers nationally, even if the state's economic recovery tracks the nation's."
Other cities under review include Azusa, Berkeley, Danville, Downey, Fresno, Inglewood, Glendale, Long Beach, Oceanside, Redondo Beach, Sacramento and Santa Monica.
Moody's will examine an array of factors, including falling tax revenue and increased spending. Any downgrades would increase borrowing costs for cities and could hinder their ability to borrow for infrastructure projects.
Three California cities – Stockton, San Bernardino and Mammoth Lakes – filed for bankruptcy over the summer, although Mammoth's filing was the result of losing a lawsuit. Last week, the agricultural city of Atwater declared a fiscal emergency and became the latest embattled community to consider bankruptcy.
Moody's, which rates 95 California cities, said it also will review San Francisco and Los Angeles for upgrades.
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Summary | Excerpt | Reviews | Beyond the book | Readalikes | Genres & Themes | Author Bio
This is a wonderful book that our
whole family enjoyed when we read it aloud
together. Erdrich writes from the heart
about the life of her 19th century Ojibwa
ancestors. The story is told through the
eyes of 10-year-old Omakayas, who is easy to
relate to because, although her lifestyle is
very different to the way most of us live
today, she is in so many ways a typical
child of any age - enjoying snowball fights
and fishing excursions, devoted to her pet
and reluctant to do her chores, eager to be
taken seriously but a little scared of the
responsibilities that come with growing up.
This is the second in a series that Erdrich plans to write tracing her family's history. The first book, The Birchbark House...
BookBrowse's reviews and backstories are a members-only benefit. Full information is available on books for a limited time when they are featured as "Editor's Choices" - but that time has now elapsed for this book.Join Today
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This book is right on time! It is undoubtedly the finest study I have ever seen on the basic principles of personal Kingdom-based finances. It is "must reading" for people who want to bless God and others with the way they steward their lives and finances.
Wealth, Riches & Moneyby Craig Hill, Earl Pitts
- LendMe LendMe™ Learn More
This book is a one-of-a-kind reading opportunity revealing Biblical Principles of Finance through the inspiration and wisdom given to Craig Hill and Earl Pitts. Having taught finance and Christian business seminars since 1984 on nearly every continent, Earl Pitts has become a formidable authority on what the Bible has to say about finance. Craig and Earl have been associates and friends for years, first acquainted through Youth with a Mission in the 1980s. Now the two have joined together in co-authoring this unique teaching filled with practical and spiritual insight that will forever change the way you view and relate to finances. By Craig Hill, co-authored by Earl Pitts.
Editorial Reviews
This book is right on time! It is undoubtedly the finest study I have ever seen on the basic principles of personal Kingdom-based finances. It is "must reading" for people who want to bless God and others with the way they steward their lives and finances.
Product Details
- 2940012803313
- Publisher:
- Family Foundations International
- Publication date:
- 04/28/2001
- Sold by:
- Barnes & Noble
- Format:
- NOOK Book
- Pages:
- 286
- Sales rank:
- 684,324
- File size:
Meet the Author
Craig Hill
Craig Hill, his wife Jan and their two sons, live near Denver, Colorado, U.S.A., where Craig and Jan give senior leadership to Family Foundations International (FFI). This is a ministry through which life-changing seminars are conducted throughout many countries of the world. Craig has also written several books, including the popular The Ancient Paths.
Craig holds a Bachelor of Arts (BA) degree from Carleton College in Russian Area Studies and Geology and a Master of Busi-ness Administration (MBA) degree from the University of Chicago.
Earl Pitts
Earl Pitts has been involved in full-time ministry with Youth With A Mission (YWAM) for over twenty years. Earl is a director of the corporation, which operates YWAM Ontario, Canada, and is part of the leadership team for all of Canada. Earl and his wife, Dorothy, completed a Crossroads Discipleship Training School and Leadership Training School in YWAM Kona, Hawaii in 1980/81. Each summer for 14 years they have led a Crossroads Discipleship Training School in Cambridge, Ontario. Earl has directed a number of the Leadership Training Schools (LTS) at the University of the Nations in Kona, Hawaii and is involved in conducting leadership seminars and teaching at LTSs in various locations yearly throughout the world. Earl is also on part-time staff of a local church.
He has taught the "Biblical Basis for Personal Finances Seminar" since 1984 on every continent and has recently been con-ducting a "Seminar for Businesspersons on Kingdom Assign-ments" in several countries around the world. This seminar deals with the release of finances and resources for the work of the Kingdom of God.
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View parents Singles in Sattler
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Feb 07, 2010 · How do you say walk the dog? ... I love you in Spanish; happy in Spanish; ... SpanishDict is devoted to... - read more
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text:
Lady Gaga Says Athletes Should Boycott Sochi Winter Olympics
"I don't think that we should be going to the Olympics at all." The singer urged Tom Daley, and other out athletes, to forgo competing in a nation with anti-lgbt laws.
1. Singer Lady Gaga congratulated diver Tom Daley on his decision to come out earlier this week, but also urged him not to compete in the 2014 Sochi Games.
2. In an interview the singer stated:
4. Friendly reminder: Sochi is hosting the Winter Olympics.
5. We will see a lot of this.
6. A little of this:
8. Gaga continued to express her feelings towards Russia's homophobic laws, urging a complete boycott of the games:
10. When asked if she would ever go back to Russia for a visit, Gaga responded:
11. "I don't think I'm even allowed in anymore because I screamed 'I'm gay, arrest me' on stage last time I was there, so…"
Check out more articles on BuzzFeed.com!
- Athletes probably won't break records at the Rio Olympics. In most events, top performers have already reached the limits of human biology, scientists say.
- Some Bernie-or-Busters protested Hillary Clinton's DNC speech, but a tightly organized plan — from chants to secret allies — kept heckling off TV.
- Sixteen people have died after a hot air balloon crashed in Texas.


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The Curious Case of Benjamin ButtonHD Closed Captioning
David Fincher
Open iTunes to preview, buy, and download this movie.
About the Movie
"I was born under unusual circumstances." And so begins "The Curious Case of Benjamin Button," adapted from the 1920s story by F. Scott Fitzgerald about a man who is born in his eighties and ages backwards: a man, like any of us, who is unable to stop time. We follow his story, set in New Orleans, from the end of World War I in 1918 into the 21st century, following his journey that is as unusual as any man's life can be. Directed by David Fincher and starring Brad Pitt and Cate Blanchett with Taraji P. Henson, Tilda Swinton, Jason Flemyng, Elias Koteas and Julia Ormond, "Benjamin Button," is a grand tale of a not-so-ordinary man and the people and places he discovers along the way, the loves he finds, the joys of life and the sadness of death, and what lasts beyond time.
Rotten Tomatoes Movie Reviews
- Reviews Counted: 238
- Fresh: 171
- Rotten: 67
- Average Rating: 7.1/10
Top Critics' Reviews
Rotten: The Curious Case of Benjamin Button leaves you colder than it should, and it shouldn't leave you cold at all.
Fresh: There's leisure to the storytelling, a splendor that captures the movie's celebratory but also melancholy ideas about our time on this mortal coil.
Fresh: A man who ages backwards will never be able to bond to another person in a truly meaningful way. We can barely be expected to return affection that isn't there.
Fresh: Fincher treats Roth's script with a visual bravura and narrative gusto far beyond the usual capacities of the Hollywood mainstream. Benjamin Button is a poetic, virtuoso feat, as eloquent and rapturous as CGI-era cinema gets.
Customer Reviews
Rental wait time!
K I totally get the marketing concept of selling the movie before you rent it but one month is a little ridiculous. I can pop into my video store and get this movie tonight and now iTunes will lose the money I would have spent here. I think you should concider shortening your wait times for renting a movie instead of losing the $ to blockbuster.
Simply, this is one of the greatest movies of all time. The flow of the story, the brilliant acting, the suberb directing, and the great nostalgic sadness that washes over the viewer once the film is done make this a movie worth watching many times. Viewers be warned, The Curius Case of Benjamin Button is one of the saddest movies ever made. Still, there is a sense of satisfaction at seeing the conlusion of the lives of the characters the veiwer came to care for in the film.
Don't hate me..
I'm sorry, but this movie just didn't cut it for me. Call me crazy.. but I was bored out of my mind. It was very long and tedious. I must have checked my watch ten times in the first hour. My friend actually fell asleep on me. Good acting and good direction.. but I feel like they could've cut it down somehow. I was getting irritable sitting in the theater that long. Maybe I'll give it another try sometime. But not in the near future. Please rent it first. I don't think this movie is for everyone. Hopefully you guys enjoy it more than I did!
Viewers Also Bought
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- Ron Howard
- View In iTunes
- $19.99
- Genre: Drama
- Released: 2008


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Top Definition
Items you need that you are going to get at a store or some other place of business.
Dude where are you going? I'm going to the store to get some requiregets
by D3M0N1Z3R87 February 10, 2011
Trending Now
Emails are sent from email@example.com. We'll never spam you.×


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- Golden Corral coming to Cape; may hire 100 workers (7/21/16)9
- Arrest warrants filed for six drug suspects in Cape (7/19/16)6
- Area groups working together to reintroduce elk in Missouri (7/18/16)1
- Suspect in downtown Cape shooting ID'd in court (7/20/16)2
- Prosecutor says shooting by state trooper was justified (7/24/16)15
- Hastings in Cape closing (7/22/16)5
- Governor signs Rep. Swan bill that equalizes child-custody criteria (7/6/16)5
- Jackson's former police dog euthanized Monday (7/21/16)1
- 'I want to see how far I can go' (7/21/16)2
- Southeast Missouri State football players, local police team up for Backstoppers benefit (7/22/16)2
Today in History
Today is Saturday, Oct. 6, the 280th day of 2012. There are 86 days left in the year.
Today's Highlight in History:
On Oct. 6, 1927, the era of talking pictures arrived with the opening of "The Jazz Singer," starring Al Jolson, a movie that featured both silent and sound-synchronized sequences.
On this date:
In 1536, English theologian and scholar William Tyndale, who was the first to translate the Bible into Early Modern English, was executed for heresy.
In 1683, thirteen families from Krefeld, Germany, arrived in Philadelphia to begin Germantown, one of America's oldest settlements.
In 1884, the Naval War College was established in Newport, R.I.
In 1928, Chiang Kai-shek became president of China.
In 1939, as remaining military resistance in Poland crumbled, Adolf Hitler delivered a speech to the Reichstag blaming the Poles for the Nazi-Soviet invasion of their country.
In 1949, U.S.-born Iva Toguri D'Aquino, convicted of treason for being Japanese wartime broadcaster "Tokyo Rose," was sentenced in San Francisco to 10 years in prison (she ended up serving more than six).
In 1958, the nuclear submarine USS Seawolf surfaced after spending 60 days submerged.
In 1973, war erupted in the Middle East as Egypt and Syria attacked Israel during the Yom Kippur holiday.
In 1976, in his second debate with Jimmy Carter, President Gerald R. Ford asserted there was "no Soviet domination of eastern Europe." (Ford later conceded he'd misspoken.)
In 1979, Pope John Paul II, on a week-long U.S. tour, became the first pontiff to visit the White House, where he was received by President Jimmy Carter.
In 1981, Egyptian President Anwar Sadat was shot to death by extremists while reviewing a military parade.
In 1989, actress Bette Davis died in Neuilly-sur-Seine, France, at age 81.
Ten years ago: Pope John Paul II elevated to sainthood Josemaria Escriva de Balaguer, the Spanish priest who'd founded the conservative Catholic organization Opus Dei. The French oil tanker Limburg was attacked by a small explosives-laden boat off Yemen's coast, killing one Bulgarian crew member. Prince Claus, the German-born husband of Queen Beatrix of the Netherlands, died in Amsterdam at age 76.
Five years ago: Pakistan's Gen. Pervez Musharraf won a presidential election boycotted by most of his opponents. British adventurer Jason Lewis finally returned home, completing a 13-year, 46,000-mile human-powered circumnavigation of the globe at Greenwich, England.
One year ago: In a poor quality audio recording, a voice identified as that of Moammar Gadhafi called on Libyans to take to the streets and wage a campaign of civil disobedience against the country's new leader. The Nobel Prize in literature was awarded to psychologist Tomas Transtromer, Sweden's most famous poet.
Today's Birthdays: Broadcaster and writer Melvyn Bragg is 73. Actress Britt Ekland is 70. Singer Millie Small is 66. The president of Sinn Fein (shin fayn), Gerry Adams, is 64. Singer-musician Thomas McClary is 63. Musician Sid McGinnis (TV: "Late Show with David Letterman") is 63. CBS chief executive officer Les Moonves is 63. Rock singer Kevin Cronin (REO Speedwagon) is 61. Rock singer-musician David Hidalgo (Los Lobos) is 58. Former NFL player and coach Tony Dungy is 57. Actress Elisabeth Shue is 49. Singer Matthew Sweet is 48. Actress Jacqueline Obradors is 46. Country singer Tim Rushlow is 46. Rock musician Tommy Stinson is 46. Actress Amy Jo Johnson is 42. Actress Emily Mortimer is 41. Actor Lamman Rucker is 41. Actor Ioan Gruffudd is 39. Actor Jeremy Sisto is 38. Rhythm-and-blues singer Melinda Doolittle (TV: "American Idol") is 35. Actor Wes Ramsey is 35.
Thought for Today: "Talking comes by nature, silence by wisdom." -- Author unknown.
Copyright 2012, The Associated Press. All rights reserved.


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Top Definition
Someone who has not grown up with the current technology.
"I wasn't born here; I travelled to these shores of technology. I'm an internet immigrant."
por Rose of Malice 09 de Janeiro de 2009
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Os emails são enviados de firstname.lastname@example.com. Nós nunca enviaremos spam para você.×


text: Weight When It Comes to Weight, Addition Is a Lot Easier Than Subtraction Don't Miss This 43 Pounds Lost: Noelia Blogged Her Way to a Healthy Mindset 8 Star Secrets to Looking and Feeling Great Sign Up for Our Diet and Nutrition Newsletter Thanks for signing up! Sign up for more FREE Everyday Health newsletters. Oops! Please enter a valid email address Submit We respect your privacy. Last Updated: 12/5/2012 top