text: DRUM Collection: Department of Veterinary Medicine Theses and Dissertations http://hdl.handle.net/1903/2762 2014-10-01T08:11:36Z 2014-10-01T08:11:36Z METABOLIC CHANGES ASSOCIATED WITH ANDROGEN INDEPENDENT GROWTH IN A MOUSE MODEL OF PROSTATE CANCER Martin, Philip Lloyd http://hdl.handle.net/1903/15469 2014-06-27T02:37:03Z 2014-01-01T00:00:00Z Title: METABOLIC CHANGES ASSOCIATED WITH ANDROGEN INDEPENDENT GROWTH IN A MOUSE MODEL OF PROSTATE CANCER Authors: Martin, Philip Lloyd Abstract: PTEN and TP53 loss are common molecular alterations in aggressive prostate cancer that progresses to castrate resistant prostate cancer (CRPC). PTEN/TP53 loss contributes to regulation of self-renewal and differentiation in prostate progenitor cells, the presumptive tumor and metastasis initiating cells for prostate cancer. TP53 plays an important role in regulating normal cellular metabolism, and loss of function is responsible for metabolic alterations in tumor cells, including increased aerobic glycolysis. We use a novel model of Pten/Tp53 deleted prostate cancer to investigate properties of tumor and metastasis initiating cells, and metabolic alterations that contribute to the evolution of CRPC. We employed a genetically engineered mouse model of Pten-/-Tp53-/- prostate cancer to develop an orthotopic model derived from a clonal cell line from the parental heterogeneous prostate carcinoma. We used histopathology and immunohistochemistry to characterize the orthotopic primary tumors and metastases. We performed metabolomic screening followed by focused analysis of HK II enzyme levels, activity, and cellular distribution in androgen replete and androgen deprived tumors. We also compared HK II levels in primary and metastatic human prostate cancer. Tumor heterogeneity was due to transformation of tumor and metastasis initiating cells with biphenotypic potential capable of basal and luminal differentiation. There was epithelial-to-mesenchymal transition (EMT) in cells of the luminal lineage. The model was capable of androgen independent growth, which influenced the differentiation of metastasis initiating cells. CRPC had increased reliance on glycolysis with increased cytoplasmic and mitochondrial-associated HK II. These metabolic adaptations afforded CRPC increased ability to withstand metabolic stress. HK II levels in human metastases were markedly increased compared to primary tumors. Pten/Tp53 loss in prostate cancer contributes to lineage plasticity in both tumor and metastasis initiating cells, contributing to heterogeneity observed in primary tumors and metastases. Increased glycolysis due to increased total and mitochondrial HK II is a metabolic adaptation that contributes to the evolution of aggressive disease, with progression to androgen independence, providing increased energy and carbon precursors for anabolic processes. Mitochondrial bound HK II blocks apoptosis and contributes to survival in the androgen deprived environment. Targeting this metabolic adaptation may provide improved treatment for this deadly disease. 2014-01-01T00:00:00Z REGULATION OF MACROAUTOPHAGY BY VITAMIN A/ RETINOIDS Rajawat, Yogendra Singh http://hdl.handle.net/1903/14646 2013-11-19T13:01:00Z 2013-01-01T00:00:00Z Title: REGULATION OF MACROAUTOPHAGY BY VITAMIN A/ RETINOIDS Authors: Rajawat, Yogendra Singh Abstract: Retinoic acids (RAs) have diverse biologic effects and regulate several cellular functions. Here, we investigated the role of RA on autophagy by studying its effects on autophagosome (AUT) maturation, as well as on upstream regulators of autophagosome biogenesis. Our studies, based on the use of pH-sensitive fluorescent reporter markers, suggest that RA promotes AUT acidification and maturation. By using competitive inhibitors and specific agonists, we demonstrated that this effect is not mediated by the classic Retinoic Acid Receptor (RAR) and Retinoid X Receptors (RXR). RA did not affect the protein expression levels of upstream regulators of autophagy, such as Beclin-1, phospho-mTOR, and phospho-Akt1, but induced redistribution of both endogenous cation-independent mannose-6-phosphate receptor CI-MPR and transiently transfected GFP and RFP full-length CI-MPR fusion proteins from the trans-Golgi region to acidified AUT structures. Those structures were found to be amphisomes (acidified AUTs) and not autophagolysosomes. The critical role of CI-MPR in AUT maturation was further demonstrated by siRNA-mediated silencing of endogenous CI-MPR. Transient CI-MPR knockdown resulted in remarkable accumulation of nonacidified AUTs, a process that could not be reversed with RA.These results suggest that RA induces AUT acidification and maturation by regulating CI-MPR subcellular location, a process critical in the cellular autophagic mechanism. 2013-01-01T00:00:00Z IMPROVED INFECTIOUS LARYNGOTRACHEITIS VIRUS VACCINES USING NEWCASTLE DISEASE VIRUS VECTOR Kanabagatte Basavarajappa, Mallikarjuna http://hdl.handle.net/1903/14174 2013-11-19T13:00:04Z 2013-01-01T00:00:00Z Title: IMPROVED INFECTIOUS LARYNGOTRACHEITIS VIRUS VACCINES USING NEWCASTLE DISEASE VIRUS VECTOR Authors: Kanabagatte Basavarajappa, Mallikarjuna Abstract: Infectious laryngotracheitis (ILT) is a highly contagious acute respiratory disease of chickens for which safe and efficacious vaccines are not available currently. In the present study, we have generated three recombinant Newcastle disease viruses (rNDV's) expressing three major envelope glycoproteins gB, gC and gD of ILTV individually. A single oculonasal inoculation of chickens with rNDV's elicited detectable level of systemic antibodies specific to ILTV. Following challenge with virulent strain of ILTV, chickens immunized with the rNDV's displayed partial protection with reduced clinical signs and shorter duration of disease compared to the control group. Our data suggested that NDV vectored ILTV vaccines are useful against ILTV infection, but might require augmentation by a second dose or require modification of ILTV glycoproteins which allow them to incorporate into the mature rNDV virions for better induction of humoral and cell mediated immune responses. 2013-01-01T00:00:00Z Review of the Molecular Biology and Epidemiology of Infectious Laryngotracheitis (Gallid Herpesvirus-1) Menendez, Kimberly Rae http://hdl.handle.net/1903/13577 2013-11-19T12:59:04Z 2012-01-01T00:00:00Z Title: Review of the Molecular Biology and Epidemiology of Infectious Laryngotracheitis (Gallid Herpesvirus-1) Authors: Menendez, Kimberly Rae Abstract: A review of the molecular biology and epidemiology of avian infectious laryngotracheitis (ILT) is conducted due to the outdated state of current ILT review material. The objective of this review is to include updated information on the molecular biology of Gallid herpesvirus 1 (GaHV-1), the causative agent of ILT, and to present the latest information on the molecular epidemiology of ILT. Recent developments in molecular biology specific to GaHV-1 have been made and are highlighted in this review, and the role of current and historical use of live-attenuated vaccines is associated with the global and molecular epidemiology of ILT. Also, target genes for detection and strain differentiation are compiled by region of the world, and the global distribution of ILT is illustrated. Additionally, the field of epigenetics related to virus-host interactions is reviewed, and the molecular, epidemiologic, and epigenetic factors investigated are related to prospects for future eradication of ILT. 2012-01-01T00:00:00Z


text:
Halloween is just
around the corner!
Every Friday and Saturday Night
in October from 7:00 PM to 11:00 PM
Brew City Fire Brigade will entertain the line each Friday Night from 8:00PM to 10:00PM
Admission cost is $14.00 per person.
Sorry, but we do not accept Debit or Credit.
For weather updates go to: facebook.com/thehauntedwoodswi.

subset: commoncrawl


text:
LiveSTAGE 1 LIVE BLOG: Tour de France riders race through the district as hundreds of thousands line Grand Depart route
This live event has finished
- The sun shone as Tour de France riders thrilled thousands of cycling fans lining the route of Stage 1 of the Yorkshire Grand Depart.
- 198 riders in 22 teams are raced from Leeds to Harrogate via Harewood, Pool-in-Wharfedale, Otley, Ilkley, Addingham, Skipton and the Dales
- Marcel Kittel wins Stage 1 of the 101st Tour de France in Harrogate
- Disappointment for British hope Mark Cavendish, who was injured in a crash close to the finish line
What a day! The spectators turned out in their thousands, the sun was shining, the eyes of the world were on our district's wonderful towns, villages and countryside, and there was a dramatic finish to Stage 1 of the Tour de France Yorkshire Grand Depart.
Join us tomorrow as we do it all again for Stage 2!
The riders return to the district on their way from York to Sheffield, passing through Silsden, Keighley, Haworth, Stanbury and Oxenhope.
Will you be there to cheer them on?
Ilkley #TDF #tdyorkshire pic.twitter.com/Lyi0CuWKRE— Robin Ghosh (@RobinNGhosh) July 5, 2014
Team Giant Shimano's Marcel Kittel puts on the leaders yellow jersey with help from the Duchess of Cambridge after stage one of the Tour de France in Harrogate
5:28pm Sat 5 Jul 14
JAtkinson says
Thoroughly enjoyed watching Yorkshire's beautiful countryside and its famous welcome. Well done all involved.
Ilkley and Addingham looked great. I'm excited about being there in person at Keighley tomorrow, though maybe Cote de Oxenhope Moor (one of the King of the Mountain stages) is the place to be in Bradford.
Looks like Leeds-Shipley trains increased in frequency but not BradfordFSQ-Shipley so, if you're going, get to Shipley and change.
Hundreds of people have streamed into Ilkley Tourist Information Centre in the past few days for advice on what to do beyond watching today's tour.
Friday and Saturday saw huge numbers of visitors stream into the centre, based at Ilkley Town Hall.
Peter Bailey, visitor centre supervisor, said: "A lot of people are staying the weekend.
"There have been a lot of people come in who wanted to make a mini break out of the weekend. We've been really busy and have been selling a lot of merchandise."
Police said a woman who fell through a roof near the Tour de France route in Skipton today was not believed to have suffered serious injuries.
The woman, who fell at High Corn Mill, Chapel Hill, was taken by air ambulance to Leeds General Infirmary.
Though initial reporters suggested she suffered head injuries, North Yorkshire Police said later her injuries were not believed to be serious and were described as cuts and bruises.
Officers were called at around 12.30pm to reports that a woman had fallen through a roof.
The woman, believed to be in her forties, was treated at the scene by ambulance staff before being airlifted to hospital.
It is believed the woman had climbed on the roof via a first-floor window.
The route of the Tour de France was not affected by the incident.
An amazing day of racing in Yorkshire but gutted for @MarkCavendish. #TDF— Le Tour Yorkshire (@letouryorkshire) July 5, 2014
The Harrogate finish line from above our Cafe Tea Room. @letouryorkshire #tdf pic.twitter.com/btYhE5KK5f— Bettys (@Bettys1919) July 5, 2014
Big disappointment for sprinter Mark Cavendish as he collides with another rider close to the finish line in Harrogate, missing a rare chance to claim the yellow jersey.
There are fears the British hope may have broken his collar bone, putting his future in the race in doubt.
German Giant-Shimano rider Marcel Kittel takes the first stage win.
Marcel Kittel wins Stage 1 of the 101st Tour de France!
Mark Cavendish crashes out at the last second.
Huge crowds await the riders' arrival in Harrogate
Le Tour in Harrogate http://t.co/52BUdamOtL pic.twitter.com/OI82TZdIeB— Adam Piplica (@AdamPiplica) July 5, 2014
To say I wasn't bother about the Tour De France the atmosphere in Harrogate is amazing! #happy pic.twitter.com/GPvV9TmIdl— Beth Marsh (@beth_marsh) July 5, 2014
Just over 10 miles of the race left, and the riders are heading towards Ripon.
Lotto Belisol and Mark Cavendish's Omega Pharma Quick-Step teams are setting the pace.
Cavendish could still be on track to realise his dream of winning this first stage at the finish line in his mum's home town of Harrogate.
Here's leading Otley businessman James Barber outside his famous tobacco and cigar shop with knitted bike made by his wife.
"We've never seen so many smiling faces in Otley - it's such a lovely atmosphere and nothing like this will happen in our lifetimes again. Tremendous," Mr Barber said.
One local business made the most of the massive crowds in Ilkley today by mixing bikes and Yorkshire staples. The Travelling Tea Ladies, a vintage tea company, took to antique bikes to travel around the town and supply spectators with traditional Yorkshire tea and cakes.
Becky Mears, from Guiseley helped found the company, and said: "There has been a lovely atmosphere today and we've had quite a few people gawping at us as we've gone past. The Yorkshire Tea has gone down very well."
They will be in Keighley when the race passes through tomorrow.
Becky Mears and Melvyn Newton of the Travelling Tea Ladies
The race may have passed through Ilkley hours ago, but the town is still making the most of the momentous day.
The Ilkley Hub at Riverside Gardens is currently packed with families enjoying food, drink and a funfair, as well as a giant cinema screen, which will be showing The LEGO Movie at 5pm.
The Hub Festival, which began yesterday, is raising money for the town's Outside The Box cafe, which supports people with learning disabilities.
Police have revealed that a boy was injured when he was hit by one of the Tour De France convoy vehicles in Ilkley this afternoon.
At 12.39pm police were called to reports of a teenage boy being injured after he was in collision with one of the team vehicles.
He was treated at the scene, and then airlifted to hospital with suspected leg injuries.
His condition has been described as stable, and police are currently investigating how the incident happened.
The peloton passes through the Dales village of Muker
The Duke and Duchess of Cambridge and Prince Harry have travelled by helicopter to meet spectators and see the Riders pass through the village of West Tanfield, near Ripon
Gutted to miss @letouryorkshire but got the best seat in the house thanks @rafredarrows @TeamSky pic.twitter.com/rIgQ4UluV2— Ian Stannard (@IStannard) July 5, 2014
It's been a long wait for some...
Riders on the B6265 between Cracoe and Threshfield
Hands up if you spotted these jazzy little fellas. #TDF pic.twitter.com/pPkHdm0Oqz— Le Tour Yorkshire (@letouryorkshire) July 5, 2014
1:18pm Sat 5 Jul 14
JAtkinson says
Brilliant to see world's biggest annual sporting event coming to Yorkshire and fab it's in Bradford District both days - helicopters and TV really showing off our finest assets.
A bird's-eye view of the riders weaving through Otley
And a prime spot for these spectators...
Spectators in Ilkley
The peloton as it passed through Skipton
Prime viewing spots were in demand as the Tour de France set off from Leeds earlier
#GrandDepart #Leeds pic.twitter.com/Bjm1gsuNWw— jonlaws (@jonalaws1) July 5, 2014
The Duke and Duchess of Cambridge, along with Prince Harry, posed for a picture in front of the Peloton at Harewood House
...before cutting the ribbon to officially start the 101st Tour de France's Yorkshire Grand Depart.
The riders leaving Harewood House earlier
The race is in the heart of the @yorkshire_dales at the moment, With views such as this! http://t.co/OPYhZmOqXW http://t.co/BIaUK4XXEA— Welcome to Yorkshire (@Welcome2Yorks) July 5, 2014
- The Tour de France is the world's largest annual sporting event, and lasts 3 weeks
- The entire race covers approximately 3,500 kms
- A worldwide television audience of 3.5billion people watch the Tour de France annually
- Over 188 countries and 121 different television channels around the world broadcast the Tour de France
- Bradley Wiggins became the first British rider to win the Tour de France in 2012, this was followed up by a second British winner, Chris Froome, last year.
Spectacular sights and support await the cyclists as they make their way through the Dales
This Yorkshire Dales National Park logo is made up of hundreds of fleeces laid out on a hillside above the route
Tour leaders as they passed through Skipton
...followed by the peloton
Helicopters arrived overhead to herald the arrival of the main body of riders in Skipton.
Sustained cheering greeted the riders as the Tour de France swept through the centre of Skipton, before heading north into Upper Wharfedale and the first climbing challenge at Kidstones – or Cote de Cray, as it is now known.
A roar went up as the crowds in Skipton heard the riders were on the outskirts of the town.
But it was nothing to the reaction when the three leaders headed up the High Street.
The leaders were three minutes and seven seconds ahead of the chasing pack, who are now on the outskirts of Skipton.
What could only be described as a royal send off! @ClarenceHouse #TDF (image via @BIGYH) pic.twitter.com/RDyWO1Vpw4— Le Tour Yorkshire (@letouryorkshire) July 5, 2014
Terrific scenes in Skipton as the leaders of the Tour de France get acquainted with the wonders of Yorkshire. pic.twitter.com/bMubCVzwvZ— Mark Reynolds (@MarkReynolds007) July 5, 2014
As swiftly as the race came through a mass exodus occured in Otley.
"We're off to Harrogate to catch the end," said keen cyclist Sally Clarker of Gargrave as she hopped onto her bike and headed off at speed.
By 12.45pm the team of imported security men were removing crash barriers and the pavements were clear.
Hundreds gathered in the spectator hub to watch the race tear through the Dales on a giant screen.
The cyclists have reached Skipton
The ducks have landed on the Tour de France route in Addingham @LeTourAddingham #TdFBD pic.twitter.com/dV9aDIRPf1— Bradford Council (@bradfordmdc) July 2, 2014
Tour riders as they passed through Ilkley
Le Tour been and gone ! Now for shopping !!! #ilkley #harrogate #TDF2014 pic.twitter.com/VnNAb08vOz— The Ilkley Shoe Co. (@TheIlkleyShoeCo) July 5, 2014
Helicopters fly over the route filming the throngs of spectators
Tour riders as they passed through Otley
The crowds in the centre of Skipton went a little quiet, maybe a sign of expectation, as the public address system told them the race was only 10 minutes away from the town....
Welcome to Yorkshire chief executive Gary Verity and Tour de France director Christian Prudhomme during the ceremonial start of the race.
The Tour de France makes its way through #Otley #TDF pic.twitter.com/8YKMBunZdO— Tom Featherstone (@tomfev) July 5, 2014
The riders are almost at Ilkley
After the flash of bikes through Otley, comes the convoy of 20 cars with hundreds of bikes on their roofs and a parade of French and British police including a van with the words Fin de Course on its doors.
"Encore, encore!" Cried the crowd.
Then came a lone cyclist in a mini-wheeled folding bike - the first sign of a fast returning normality.
The anticipation is building in Ilkley
Blue sky, yellow T-shirts and thousands of people in Ilkley for Le Tour #TDF #YorkshireGrandDepart pic.twitter.com/dusXDt3ZKM— Simon Blakeley (@BlakeleyLegal) July 5, 2014
At 12.16 a shockwave of cheering ripped through Otley as the Tour de France tore past the famous maypole and on through the town.
The shouts and whistles of delighted residents and visitors greeted and followed the elite riders on their way to Ilkley and the Dales.
Back home from work just in time to catch the Tour De France pass through Otley. Beautiful. #TDF2014— Colin Burrill (@colinburrill) July 5, 2014
Tour fans in Skipton raised a cheer as the race started from Harewood House.
They were watching on a big screen at the town's main spectator hub in the town hall car park, while crowds on the nearby High Street were treated to the sight of the Tour "caravan" driving past.
Crowds in Otley
Crowds in Otley
Crowds in Otley
Ooh exciting @letouryorkshire nearly at Otley. I'm about to see Tour de France peleton live! Lovely sunny day too.— Tracy Griffen (@tracygriffen) July 5, 2014
The riders are just arriving at Pool-in-Wharfedale. Here are the crowds in Otley eagerly awaiting their arrival...
In Otley the french love of fine wine being copied in Otley as boxes of Chardonnay emerging from back packs.
Meanwhile, the health benefits of Yorshire beers being enjoyed from hundreds of plastic cups.
And they're off!! The Red Arrows fly overhead as the ribbon is cut! The cyclists ride through the grounds of Harewood House towards the official starting flag.
The French and British national anthems are played in true Yorkshire style by a brass band at Harewood House as the riders wait for the ribbon to be cut to start the race.
British sprinter Mark Cavendish, left, talks to Team Sky favourite Chris Froome prior to the start of the race.
The riders are now arriving at Harewood House
Food stalls packed with Yorkshire fare are ready for the hungry hoards after the race in Otley
Skipton's High Street was declared "full" of spectators just after 11.10am, shortly before the Tour de France "caravan" of sponsor vehicles starting coming through, the mounting excitement of the crowds.
As the Tour cavalcade heads into the Dales, late arrivals in the centre of Skipton are being directed to the spectator hubs in the town hall car park and in the canal basin.
Coats are off and the suncream is going on as excitement and temperatures rise in Otley.
Otley's Lizzie Armitstead is at Harewood House awaiting the teams' arrival
Nice to see @L_ArmiTstead here in Yorkshire to see @letour. Hope you enjoy it! #TDF pic.twitter.com/bsZAGWSggy— Le Tour Yorkshire (@letouryorkshire) July 5, 2014
Great atmosphere at the start in Leeds. @GeraintThomas86 meets the public #TourFever pic.twitter.com/sClWOaisqk— Team Sky (@TeamSky) July 5, 2014
Good Luck! "@letour: Outstanding crowd on the way to the official start #TDF pic.twitter.com/p6Lyv0mQ7D"— NHSOrganDonation (@NHSOrganDonor) July 5, 2014
@letouryorkshire @letour Go! CAV Go! Blink and you'll miss him! good luck Mark! we are with you all the way.— Steven King (@captain_king_uk) July 5, 2014
Amazing caravanne going through #ilkley for #tourdefrance pic.twitter.com/34Kwo8GNLn— Stuart Hyde QPM (@StuartHydeQPM) July 5, 2014
Stuart Moore, from York, and Carolyn Richards, of Doncaster, arrived in Skipton at around 7am.
Stuart said: "This is a once in a lifetime thing. It's all about the atmosphere, and is not so much the cycling because the cyclists go past so quickly."
Carolyn said Skipton is "decked out" for the occasion, saying: "It's fabulous. I always watch it on TV, and now I can watch it in person. It's also good to see all the amateurs cycling the route so early in the morning."
Cyclists Tim, Helen and Michael Trew came from Bristol, Leeds and London, respectively, to watch the event.
Tim said it took him seven hours to drive up from Bristol and he admitted he saw a lot of cars carrying bikes on the way.
Speaking from outside Skipton Train Station, the trio were cycling into the Dales to see how they could get before the roads were shut to cyclists. Helen anticipated they would be stopping in Grassington.
She said the Tour was great for Yorkshire. "Leeds doesn't have much of an identity, so it gives them a sense owning something. It's good for tourism."
"It's amazingly well organised, I thought it was going to be chaos."
Cyclists Phil Knights and his son Ed came all the way from Devon to enjoy the world's largest cycling race.
Speaking on Skipton's High Street at 7.30am, Phil said: "It's brilliant and there's a great atmosphere, even at this time of the morning."
A member of Yogi Cycling Club in Plymouth, Phil added: "There are some decent climbs and the narrow roads of the Dales will present a big challenge to the cyclists."
The anticipation builds for the crowds in Skipton...
Sean and Jayne Steele came from Preston with their four children, Grace, Frankie, Archie and Harvey, and the children's grandparents Margaret and Alan Steele.
Staying in a caravan at Paythorne, near Gisburn, the family of eight, along with their Boxer dog Roxy, arrived on at 6am and set up chairs along the barriers on Skipton's High Street.
Alan said: "It's good for Yorkshire. Skipton has been terrific, and I can't praise the people and the shops enough. I'm looking forward to seeing the riders flying through."
After the parade starts coming through Skipton at around 10.50am, it is anticipated the first of the Tour riders will arrive on the High Street at 12.49pm.
Sean appreciated the hard work and early opening of Skipton's local businesses.
He said: "I'm glad the shops have made the effort to accommodate us."
Many local businesses, like Hettie's cafe on the High Street, opened early for Tour-goers.
Owner David Roberts said he has a thousand bacon baps and picnics to sell on the day.
Although he said trade had been slow to start with, he said: "It's a lovely atmosphere. We want people to have a good time and remember this event."
Chris and Susan James came from Longridge, near Preston, to see the riders pass through Skipton.
They arrived on the High Street at 5.30am and also said it was very quiet early on.
"We go on holiday to France a lot but never actually see the event itself ," said avid cyclist Chris. "So to get the chance to see it in England is fantastic."
The couple believe that Chris Froome could win the Tour de France, but they think Mark Cavendish is favourite to win the first stage.
The caravan of around 180 promotional vehicles is on its way through the district, and the competitors are on their way to Harewood House to begin the 101st Tour de France race.
The Duke and Duchess of Cambridge will see the race start at Harewood House
The caravan is making it's way along the route of Tour de France. Huge crowds cheering in Leeds @letouryorkshire pic.twitter.com/iZz9uBIo3V— Stuart Andrew MP (@StuartAndrewMP) July 5, 2014
The ceremonial procession has just from Leeds city centre, with Mark Cavendish leading the way. The ribbon was cut and the riders now head towards Harewood House, where the race proper will begin.
The sun has come out as the crowds in Otley pack the pavement
#skipton is buzzing! Crowds getting ready for the #tdf2014 #tourdefrance #granddepart #cycling pic.twitter.com/0c4vWsQkGX— Craven Museum (@CravenMuseum) July 5, 2014
Young Tour fans in Skipton await the arrival of their favourite rider Chris Froome
The caravan has just ended in Otley, so the excitement is building for the arrival of the bikes themselves.
Thousands of smiling faces of all ages now pack the pavements the whole length of the route through Otley.
The Dales gears up for the Grand Depart's arrival
"@janetrewhella: #TDFyorkshire Ey up. Reet warm. #otley pic.twitter.com/DKjI6aSqkc" the best pic representing Yorkshire tour de france— NYP Helmsley (@NYPHelmsKirkby) July 5, 2014
Fancy french floats are being greeted with cheers and laughter in Otley.
Motorbike gendarmes ride amongst glamorous fast floats advertising unknown french foods - but there goes one for the taste of home - oven chips!
A quick parade of pink Land Rovers from Sheffield Hallam university passed by.
A broad band of blue sky now over Otley Chevin. More than enough to make a gendarme's trousers.
View @skipton #skipton #tourdefrance pic.twitter.com/p6eMnzRbMC— Nicky (@nickycooper) July 5, 2014
So many people in ilkley #tourdefrance pic.twitter.com/gO3PrfFOqC— Vicki O'Connell (@vocster) July 5, 2014
The sun has finally broken through to give Otley a yellow glow as anticipation.
The Tour promotional caravan has arrived in Otley with great shouts of "It's TODAY!"
The vanguard is speeding through Otley with French cries of "'Allo Yorksheer! And the Haribo cars are hurling sweets at 40mph.
Souvenir boxes of Yorkshire Tea are flying out from passing vans.
French safety staff are asking people to stand well back - in the nicest gallic accents.
Weather for today's stage looks more promising than for tomorrow. Showers should clear as the riders make their way towards the Bradford district, with even some sunny spells anticipated, with higns of 17C.
#Otley is heaving with anticipation #tourdefrance pic.twitter.com/w2JCdCnhrQ— Washburn Heritage (@Fewstonchurch) July 5, 2014
It's getting busy in Otley!! #letouryorkshire #tourdefrance #tourdeyorkshire pic.twitter.com/d6YBuFcdyf— Helen Gregory (@Hellyg100) July 5, 2014
Scenes from Leeds city centre Grand Depart start line
Four of the riders taking to the start line in Leeds this morning are British Chris Froome, Mark Cavendish, Geraint Thomas and Simon Yates will all begin the three-week event.
Cavendish is targeting a 26th Tour stage win of his career, but a first yellow jersey, in his mother Adele's home town at the end of Saturday's 190.5-kilometre route from Leeds, but defending champion Chris Froome (Team Sky) carries overall hopes.
Just arrived at the start. Massive crowds. Cheers for all the messages of support!!— Chris Froome (@chrisfroome) July 5, 2014
Wayzgoose Morris dancers perform in Otley beside the Tour route.
Anita Simpson of Otley Wayzgoose morris dancers says "it's great!".
Just a little bit excited about today's @letouryorkshire stage. This weekend is the culmination of years of hard work - can't wait! #TDF— Welcome to Yorkshire (@Welcome2Yorks) July 5, 2014
We're on the road. It's a long way to Paris! #TDF #TourFever pic.twitter.com/TFzpyKeqoD— Team Sky (@TeamSky) July 5, 2014
Rescued chihuaha Rosie stayed safe in the arms of RSPCA shop managers Ann Holey (Right) and Margaret Kay as numbers swelled on Boroughgate Otley.
"We spent the night here in sleeping bags - it's fantastic for the town and the county.
"Everyone around the world will see how lovely it is in Yorkshire," Ann said.
Thousands of cycling fans are now lining the streets of Leeds city centre in anticipation of the big event
The parish church bells in Otley rang out an early morning welcome to thousands of Tour de France fans gathering in the town as local butcher did brisk trade in bacon butties.
Zoe Lamming (left) husband James and beret-wearing baby Bobbie sported french style with friends visiting from London.
They were some of the hundreds already lining the route through Otley by 9am.
"We live in Otley and are having a great time with mes amies!" Zoe said.
The centre of Skipton has an unfamiliar look to it this morning. With the Grand Depart of the Tour de France due to pass through at around 10.45am, final preparations are being put in place during the early morning rain.
Skipton's High Street's setts are bounded by steel barriers for the thousands of people expected to watch the world's top cyclists ride through the town before heading into the Dales.
Most of the barriers were put in place on Friday evening and some people had already claimed prime viewing spots by about 6am this morning.
Smaller communities have been making their own preparations, as villages take on a carnival appearance and fields are thrown open as temporary car parks and viewing points. Less welcoming was the morning rain.
It later stopped, though the skies remained grey. Forecasts suggest they may clear by the middle of the day.
Tourmakers Mary Cooper (left) and Ann Wellings have been greeting race fans in Otley from first light.
"Numbers are building now and the the sky is brightening," said Ann, from Leeds.
"People are well prepared and it's going to be a brilliant day!"
With several hours to go, Ilkley is already filling up with spectators for the race.
The town has been counting down the days to the Grande Depart since it was first announced as being on the route way back in January 2013, so anticipation is high.
Each train arriving in Ilkley is packed with hundreds of cycle fans dressed in Yellow jerseys, berets and carrying Tricolours and Union Jacks.
The Bradford to Ilkley train was packed, so the Grande Depart has obviously captured the imaginations of people across the district.
Welcome to our live Grand Depart blog. Follow us as we follow the Tour de France riders from Leeds through the Bradford district and out into the Dales.
The caravan of around 180 promotional vehicles will set off from Leeds at 10am, and the competitors are expected to set off around two hours later.


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What We're Up To
We invited 90 special guests to roll up their sleeves, channel their inner brewer, and create a one of a kind cask! Enjoy a plethora of Real Ale created by our Retailers, a few Celebrities, some Media Folks, Local Breweries & our favorite Charities under the watchful eye of SweetWater's brewers. Pre-Sale $35 online or $40 day of for unlimited Cask samples. Of Course SweetWater's award winning lineup will be flowing as well and the brewery will be open for tours throughout the event.
The Skinny
What: "Brew Your Cask Off" Cask Ale Festival
When: November 8, 2014. 6:30 PM - 10:30 PM
Where: Under the tents in front of SweetWater Brewery
Price: $35 Online Pre-sale ($40 Day Of)
2013's Winners
2013 Judges Panel Awards
1st Place: #67 The Giving Kitchen - "Second Helping IPA"
2nd Place: #73 Manuel's Tavern - "Basil Slap"
3rd Place: #48 Universal Joint - "Shive-R Me Timbers"
People's Choice Award
#9 Cypress Street Pint & Plate - "The Musketeer Beer"
Biggest Loser
#44 Brickstore Pub- "Coffee IPA"
2012's Winners
2012 Judges Panel Awards
1st Place: #62 The Charleston Beer Exchange - "Nuttin Butter"
2nd Place: #11 The Fred Bar - "Fred Juice"
3rd Place: #12 Taco Mac - "The Chubby Chocolate Bunny"
People's Choice Awards
#22 Cypress Street Pint & Plate - "The Elvis Peanut Butter and Banana Porter"
Biggest Loser
#31 Bhojanic- "Manali Gold"
A Portion of Proceeds from the Event to Benefit


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Our mission is to help people manage the risks of everyday life, recover from the unexpected and realize ... more
For more than 80 years, we've made it our business to give our customers peace of mind by making their in... more
Local Premium Listings
© 2014 Local Corporation - US Patent 7,231,405
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Need Help With Starting A Blog? Worry No More!
When starting a blog, it is important to decide first what category or field you want your blog site to be about. Let us say for example, you want your site to be all about the latest gadgets and technologies. Actually, that will not be a bad idea since the technology is what everyone waits for. Since everyone wants to be updated in every new gadget that becomes trending in the public, writing blogs about technology will not be a bad idea after all. A good idea would be writing about the latest innovations, possible things that can be invented, and innovations that inventors are currently working on.
Starting a blog is not as easy as it looks like. Before you can actually go to the site where you want to start writing, you have to make a thorough planning. Some plans may include designing your preferred layout from a scratch and figuring out how you will make your design possible in terms of HTML codes or mixing colors. Although you can actually pay people to create designs for you, it is still better if you do it yourself so you can attain what you really want your blog site to look like.
Inspiration Will Keep You Motivated To Endlessly Create A Blog!
There are many things around us that can serve as your inspiration. Researching can be one hard task but at the same time, it is fun for a passionate person – a person that has passion for writing articles and exposing them to the public as a blog. In order for you to create a blog, you will need to possess skills and passion. How important are these two?
Why do you need to have passion in writing? Why is passion so important in order for you to create a blog? Well, it is simply because if you have passion in writing, your mind is set that you are born to write. If so, this kind of mentality will keep you interested and motivated in everything you do or write. Including research, you will never feel tired when researching about things that you are not even interested in.
Talent or skills are required as well. Why? How can you be passionate about something you are not good at? It is very simple to write but it takes talent or skills to write about something really good and to talk to people in an engaging way or in a way that people will be invited and convinced. Some great ideas for beginning bloggers can be found here.
Snoring: Hereditary Or Not?
There is no known evidence that snoring is hereditary; a number of people start snoring as they get older. Gaining extra weight could also cause snoring; regular exercises are important to keep neck muscles toned to prevent snoring. Colds, flu and other allergies could create temporal snoring. Most people who snore may wake up frequently in the night due to thirst caused by a dry mouth as the airways get obstructed forcing them to breathe through the mouth. Nose strips used could fall out resulting to snoring; a number of snoring mouthpiece reviews given recommended this piece because it is comfortable to use and it remains in position all night long.
A family member who smokes and abuses alcohol could keep home residents awake due to their loud snoring. A snoring mouthpiece will eradicate this problem immediately; you need to talk to this person gently so that they can use this piece. Snoring can occur to everyone due to several factors; it is important to obtain professional help if you wake up frequently in the night with a racing heartbeat. Using a snoring mouthpiece will ensure a good night rest as recommended by those who have written mouthpiece reviews.
A Study On The Best Snoring Pillow
Snoring is the worst nightmare that happens to some people. This could cause problems in families where one person is giving another a hell of time while they are asleep. This matter is far detrimental to even marriages where some could even separate because one spouse snores all night and the other is irritated not to sleep. A snoring pillow would be helpful in such situations as it not only reduces this disorder but could eventually eliminate it. It supports the head and neck in a good position to keep the nasal passages open because its obstruction by either relaxing of jaws or tongue would make one to snore.
Which is the best snoring pillow? The best choice of this item should be based on its efficiency and effectiveness. A good one should be augmented to fit the head and neck and hold them in an elevating manner to keep nasal passages open to allow free flow of air in and out of the body. Foam material should be the most effective as it gives extra comfort to the user. Above all, the right item of this kind should be able to give other advantages like reducing back pains and also headaches as one relaxes comfortably on them.
Cross-Docking Takes Some Getting Used To
Warehouse-management systems make cross docking possible. But in most cases, these packages require customization to do the job.
Cross-docking has become the rage in retailing and other industries as companies seek to convert their warehouses from storage facilities to flow-through distribution centers. What's the attraction of cross-docking – the practice of breaking out individual lots from an inbound shipment and reassigning them to another shipment for outbound delivery? The technique saves both time and money. Businesses find that cross-docking allows them to reduce inventory and get product into the hands of customers and consumers quickly.
Successful cross-docking, however, requires sophisticated information technology. It's important to manage the flow of information as adeptly as the flow of cartons. Each carton or pallet from an incoming truck must be accurately identified at receipt, allocated instantaneously to a purchase order, and then routed to an outbound door for delivery.
If done properly, units are never placed in storage or left waiting in a staging area. "Cross-docking sounds fundamentally simple," says Ken Walker, a consultant with Kurt Salmon Associates in Atlanta. "But it's more information-intensive than facility-intensive if executed well."
What does a company interested in cross-docking need in the way of information technology? Most warehouse-management systems (WMS) packages on the market claim to offer a module to facilitate the practice. But many WMS packages fail to make the grade. As Moe Trebuchon in the Systecon division of the Atlanta-based consulting firm Coopers and Lybrand notes: "Not all packages have what it takes for cross-docking."
Smart software buyers, therefore, will investigate the features of any WMS package under consideration. They should keep in mind that off-the-shelf packages do not yet exist to enable high-volume cross-docking. True flow-through receiving and shipping requires software customization, especially if the warehouse uses automated materials-handling equipment. "Each package has its own pros and cons, and will require some kind of retrofitting or customization," warns Jim Seber of Seber Logistics Consulting Inc. in North Brunswick, N.J.
Getting a Custom Fit
When it comes to purchasing software for cross-docking, a manager first must give some thought to the degree of flow-through replenishment required for the facility. Cross-docking, after all, can assume many forms. In its simplest form, a worker operating a pallet jack removes a load from an inbound trailer and then hauls it across the warehouse floor to the out-bound trailer on the shipping dock.
More complex versions of cross-docking use automated materials-handling equipment to mix and match hundreds of boxes at a time. "The way Wal-Mart cross-docks is different from the way a specialty store does it," notes Michael Wagner, a manager with Deloitte & Touche Consulting Group.
As a fundamental requirement for cross-docking, any WMS package has to have some type of inbound-scheduling capability that can note the arrival of inbound goods and then assign those goods to meet outbound orders. "You need the ability to pre-allocate incoming receipts to outbound demand," explains Trebuchon. If it has that ability, a WMS package can facilitate what's known as "opportunistic cross-docking." This means the software can separate the load into lots and designate those lots for an order. "Material that's received will be directed to the staging area [for consolidation into outbound trailer loads] instead of storage," explains Ron Reimink, manager of marketing and sales for Ann Arbor Computer, a WMS software maker.
But cross-docking in its most complex form eliminates the need for a staging area, where some product waits a short period for remaining product required to fill an order. Flow-through receiving and shipping, as it's known, requires automated materials-handling equipment such as sortation conveyors. "In the mechanized environment, you can be almost certain that any WMS package would have to be tweaked to handle communications with the sortation controller," says John M. Hill, a consultant with Cypress Associates in Watsonville, Calif.
Unlike, say, word-processing software, whose packages now come standard with a module for printer configuration, WMS packages cannot be "flag-driven" to suit the individual designs for automated cross-docking. "Few packages interface with the automation," says Wagner, "so companies must buy the WMS package and then modify it to work with the materials-handling equipment."
That equipment usually is controlled by special software called Warehouse Control Systems (WCS). In particular, this software governs the programmable logic controllers (PLCs) that direct carton flows along conveyor paths to specific shipping docks. "What the WMS typically does is the planning," says Wagner, "while the WCS executes the plan."
Because up-to-the-minute records on inventory are required, the communication between WMS and WCS must be instantaneous or in real time. Wagner notes that the typical integration with materials-handling systems has been batch-oriented, processing information in lots at specific intervals. The higher-end packages tend to be real time, he explains. As the materials-handling system makes a change to the inventory, the WCS tells the WMS that a change has been made.
Costly Code Changes
Because each WMS product must be tailored to a specific materials-handling operation, automation of cross-docking operations requires extensive modification of the underlying software code. As a result, the software vendor, a systems integrator, or consultant must be retained to make code changes in the program. "This is complex software," explains Thomas Ryan, research director in the integrated logistics strategies services at Gartner Group, "WMS programs have 100,000 to 200,000 lines of 'C' code."
Wagner reports that customization can be handled in one of three ways. If it's simple, the vendor may be paid extra to do the modifications. But because the software business is booming, vendors often lack the resources to handle the job. In this case, the vendor hires a consulting firm for the software deployment and oversees the project installation or outsources the entire project to a consulting firm.
Not surprisingly, this customization jacks up project costs. If a company is willing to change its warehousing practices to accommodate the operational restraints imposed by a software package, Wagner says, it might only have to pay between $100,000 and $1 million for a cross-dock solution. But companies seeking real-time inventory control and operating complex materials-handling systems should be prepared to spend anywhere from $250,000 to $2 million for the software package and the concomitant integration with existing computer systems. "You pay more for customization," says Wagner. "But you get it the way you want it."
Wagner adds that companies also should be aware that the amount and type of materials-handling equipment can complicate the task of installing software for cross-docking. The more materials-handling equipment you have, he notes, the tougher it will be to implement a WMS system.
In part because of the cost and extra work required for implementation, cross-dock functionality has not been a standard feature in WMS packages. But that's changing fast, say those in the software business. "Rarely in the past did [cross-dock functionality] show up on a [request for a proposal]," says Jim Coker, a vice president at WMS software maker Acacia Technologies. "But I'm starting to see more of it as a requirement. In the near future, it will become a minimal business requirement."
Lessons Learned
What do you believe are some of the key lessons to be learned from the airplane crash in the Everglades in May 1996?
After evaluating a host of documents and interviews, I believe there are two important lessons that shippers of dangerous goods should learn from this unfortunate incident. Although in that case the shipper was an aircraft-repair facility, the lessons can apply to everyone.
First, all companies should pay much greater attention to the OSHA provisions on hazard communication and to the more recent obligation under 29 CFR 1910.1201 to maintain Department of Transportation-mandated labeling on packages that come into the workplace bearing DOT warnings. Several years ago, after a disastrous explosion in a truck trailer parked at a construction site, investigators found that DOT "Explosives" placards had been on the trailer when it was delivered but had been removed because the trailer no longer was used in transportation.
That led to a congressionally mandated change at OSHA, compelling anyone receiving packages with DOT warning labels or placards on them to maintain the warnings that were affixed to those packages when they were delivered. Even if the incoming materials no longer are in transportation, the receiving employer is obligated to maintain the DOT warnings or replace them with equivalent OSHA hazard-communication warnings.
At too many distribution, maintenance, service, and similar facilities that receive DOT-labeled cartons of hazardous materials, employees immediately discard the outer packaging and place the hazardous parts on a shelf, from which they are consumed or reshipped one at a time. If the DOT warnings or OSHA hazard-communication warnings are not maintained on individual units while they are in storage, the employee who later reships one of those units cannot tell by looking at it that it is DOT-regulated. As a result, the units may end up being shipped without a hazard declaration. Meeting OSHA's mandate to keep hazard warnings on packages after receipt will minimize the probability of incurring such a serious DOT violation.
The second major lesson is that many individuals who have not previously been identified within their organizations as "hazmat employees" – and therefore have not been certified as having been trained and tested under the DOT hazmat rules – are in fact offering DOT-regulated hazardous materials for transportation. This problem is more common than you may think: The majority of the cases now being pursued by the Federal Aviation Administration against shippers of undeclared hazardous materials involve violations by non-transportation types, including mechanics; service representatives; and sales, R&D, and secretarial staff.
In my view, any employee authorized to use a company account to ship products by FedEx, UPS, the U.S. Postal Service, or other express carriers must be considered a hazmat employee and therefore must receive appropriate training, unless the company has put a mechanism in place to limit his or her actions. A brief hazmat-awareness session for all employees, while not guaranteeing compliance, at least can reduce the potential for a non-transportation person to ship hazardous materials in
ignorance. I usually recommend that a short awareness session be included in general orientation training for all new hires and that it be associated with OSHA hazard-communication training concerning employees' awareness of the OSHA provisions in 29 CFR 1910.1200 and .1201. Limiting employees' access to express carriers and the Postal Service also helps.
If preventive measures like these result in the avoidance of even one FAA penalty or – worse yet – a hazmat incident, your company will be far ahead of the game.
Off The Record Negotiating Proves Valuable
Contrary to what some bargainers think, private talks are a necessary part of negotiation. Off-the-record talks often are the rule, not the exception. They bridge the gap between what is wanted and what is possible. Not everything that must be said can be said at the table. A good negotiator knows that.
The North Vietnamese and American peace-talk delegations met but once a week in Paris. The sessions were vitriolic. Yet, not far away, our top negotiator attended tea after tea with their top negotiator. The teas were cordial, even while the delegations were shouting at one another at the table. Formal discussion often serves a public or propaganda role. Off-the record talks permit things to be said that give both sides a glimpse of the real issues and problems. Such discussions best set the stage for later compromises.
In her 10-year labor-relations study, Ann Douglas discovered that formal meetings in the last phase of labor bargaining were shorter, caucuses longer, and private talks frequent. Business negotiations are no different. It's good to have a drinking buddy throughout negotiations. At the last stage, it's almost essential.
Social or off-the-record discussions are a form of legitimate communication between buyer and seller. In an informal setting, they can let their hair down and discuss problems person to person. They can gripe about constraints imposed by unreasonable people back home. They can share those things that unite humans no matter what their cause – children, spouses, and high taxes. These discussions act as a safety valve. They permit problems to be solved, assumptions to be tested, and assessments of integrity to be made under non-structured conditions.
Off-the-record discussions serve another function not always recognized. They permit the informal and unofficial leaders of a negotiation to express themselves on a sub-rosa basis. For example, it is common procedure to designate the buyer as official leader of the purchasing team, but often it is the engineer who really leads the team because he or she has superior product knowledge and may, in some cases, know more about negotiating as well. Off-the record discussions on a person-to-person
basis permit these realities to surface without disturbing formal status relationships.
Informal talks are mandatory when official positions have hardened and deadlock is imminent. Though it may be difficult to say anything conciliatory at the table, a few well-chosen words after dinner can indicate unofficial willingness to compromise. A series of social meetings may be necessary to elaborate on details so that public and private positions on both sides can be coordinated without loss of face.
The effective negotiator knows how important off-the-record negotiations are. However, like almost everything, there are two sides to these sessions. The dangers should be understood and precautions taken as follows:
* Be wary of confessional sessions. They may be one-sided. You can easily give away more than you get back.
* Drinking-buddy setups are common, especially if one party can control his liquor better than most.
* Informal discussions may be used to present false pictures. It is easier to plant phony information in an informal setting because people lower their guard.
* Some negotiators have an intense need to be loved. They become generous in a "loving" social climate.
* People with "little-shot" complexes exhibit greater deference in a social setting than under formal conditions.
Killing It With Outsourcing
A study of how businesses are using third-party logistics services and whether they are satisfied with them indicates that outsourcing continues to gain ground, albeit slowly, and that most users are satisfied with the service they are receiving.
The study, conducted by the University of Tennessee's Center for Logistics Research through a grant from Exel Logistics, is the second in what is expected to become an annual series of surveys. The author of the study, UT Professor of Logistics and Transportation C. John Langley, presented the results at the Council of Logistics Management's annual conference in Chicago earlier this month.
The results of the study show that 73 percent of respondents in the five industries examined (automotive, chemicals, computers and peripherals, consumer products, and medical supplies and devices) are using third-party logistics services or considering using them for at least some functions [ILLUSTRATION FOR FIGURE 1 OMITTED]. That's up only one percentage point from the 1996 study. In certain industries, however, the gains are more dramatic. For instance, 87.5 percent of the respondents from consumer-products firms said they were using or were considering using third-party services. That's up from 74.6 percent a year earlier. On the other hand, respondents from medical-supplies firms showed a drop in third-party use, to 56.8 percent from 63.6 percent in 1996.
What bodes well for the third-party industry is that 89 percent of third-party users said they expected to maintain or increase the use of those services. That's up from 81 percent in 1996. And those that do use third parties spread the wealth: Respondents said that on average they used 14 providers of third-party services.
The functions they outsource will be familiar to most logistics managers. Freight-bill auditing and payment was the most frequently outsourced activity, used by 63.8 percent of the respondents that already use third parties. That's followed by outbound transportation (58.8 percent), warehousing (58.1 percent), inbound transportation (43.8 percent), and freight consolidation and distribution (42.5 percent).
Most buyers of third-party services choose their providers through a formal bid process. Seventy-five percent said they used the bid process to develop a short list and then negotiated with a limited number of providers. Another 15 percent chose a provider through the bid process, while the balance of those using third parties negotiated with a single supplier on a sole-source basis.
As for compensation, transaction-based fees are most common, used by 64.4 percent of third-party users. Slightly more than half also said they used flat-rate pricing. Only 21.9 percent cited cost-plus payments, and just 16.8 percent said they based compensation on a percentage of savings.
Overall, users of third-party services were satisfied with their providers' performance, with 83.3 percent indicating that their outsourcing efforts were either extremely or somewhat successful [ILLUSTRATION FOR FIGURE 2 OMITTED]. Only a single respondent replied that efforts had been extremely unsuccessful.
That's not to say that third-party relationships are without problems. More than one-third (36.9 percent) of respondents said that service-level commitments had not been realized. In addition, 31.8 percent reported that the quality of third-party employees did not live up to expectations.
Respondents who do not use third parties most frequently cited loss of control as their reason for not using them. The second-most common factor cited was the concern that using third parties would lead to increased costs.
Yet shippers that actually use third-party services apparently do not share those fears. Although more than half of the users said they regarded logistics as a core competency of their firms and 80 percent said they believed logistics provided a key competitive advantage, they still were willing to outsource some of those activities. Langley concludes, "While this issue also may have much to do with how one defines core competency, the study results document the fact that many firms [that] use third-party logistics services also view logistics as an area of strategic and competitive advantage.
Highway Bills Change The Game
Bud Shuster, chairman of the House Transportation and Infrastructure Committee, has talked for years about taking the Highway Trust Fund off-budget and increasing spending on the nation's highways by billions of dollars. Late last month, though, the Republican from Pennsylvania found his way barred by an agreement between Congress and the White House to balance the federal budget.
In September, the House Subcommittee on Surface Transportation had unanimously approved Shuster's plan for a three-year spending bill, which would have authorized $102 billion for highway and transit programs. But when Shuster scheduled a "markup" – a vote by a full committee approving the bill for the entire House's consideration – the House Republican leadership pressed committee members to back off. Bowing to that pressure, the full committee instead proposed a six-month extension of the current highway bill, the Intermodal Surface Transportation Efficiency Act (ISTEA). The full House adopted that proposal on Oct. 1.
At the center of the disagreement between Shuster and Republican House leaders is how to handle income in the Highway Trust Fund. Although on paper, the trust fund annually accumulates large surpluses, those funds in fact have been used to reduce the federal deficit. That makes the Highway Trust Fund and similar programs an essential part of the balanced-budget deal that Congress and the Clinton administration hammered out earlier this year.
Shuster's bill would have taken the funds off-budget and used them to increase spending on infrastructure projects. The House leadership feared that if Shuster were allowed to present his committee's costly three-year plan to the full House, other committee chairmen would follow his lead and introduce expensive spending projects. That could very well cause the entire budget agreement to collapse.
The six-month extension approved by the House buys Shuster some time. He apparently hopes that by delaying action now, he can wait until a strong economy boosts highway receipts beyond the estimates used in forging the balanced-budget agreement. That would give his committee room to push for greater spending on highway projects.
And push it will: After abandoning its original three-year bill, the committee now has endorsed a six-year bill called the Building Efficient Surface Transportation and Equity Act, or BESTEA, which would authorize $218 billion in spending. To prevent the full House from taking control of it, the committee has not yet formally adopted the six-year plan. The committee plans to introduce BESTEA in the spring, when the six-month ISTEA extension expires.
Senate Bill Advanced
The Senate Environment and Public Works Committee, meanwhile, has forwarded its own bill to the full chamber. That proposal would authorize $145 billion in highway and transit spending over six years – $73 billion less than BESTEA. The Senate was expected to act on that bill early this month, after ISTEA expired on Sept. 30.
Passage of the Senate bill is far from certain, though. One key issue is the proposal's formula for allocating funding to individual states. Legislators from so-called donor states – those whose drivers pay more in fuel taxes than the state receives back from the government in highway funds – have pushed hard for a formula that assures their states would get most of that money back. But opponents scoff at the donor-state argument, saying that it ignores total federal taxation and spending, which often makes net donors of the states that appear to benefit most from highway spending.
Under the current Senate committee proposal, a number of states would lose funding they enjoyed under ISTEA. Sen. Edward Kennedy, a Massachusetts Democrat, called it "an outrageous and unfair proposal that would devastate Massachusetts and the important ongoing transportation projects in our state. … This is a raid on Massachusetts by other states, and I am determined that it will not succeed." Other senators whose states would lose funds under the proposal are likely to join forces with Kennedy.
If the Senate manages to approve its bill rather than agreeing to the extension, the next step would be to reconcile the two versions in a conference committee. At press time, it appeared unlikely that the House and Senate would reach agreement before Congress adjourns, probably in early November.
In fact, House transportation committee members are not expected to meet with their Senate counterparts, even if the Senate should pass the six-year bill. Not only is the committee chairman opposed to the Senate's lower spending proposal, but he also wants to control the process and protect his committee's own six-year plan. A Shuster spokesman was blunt. "It's our turn to call a conference," he said. "If the Senate passes a six-year bill, there will be no conference."
The House Transportation and Infrastructure Committee is betting that BESTEA will have better prospects of passage in the spring than its previous proposal. The committee insists that the six-year spending plan is consistent with the budget agreement because it would increase funding for transportation only if there are offsetting revenue increases and budget targets are being met.
But Shuster's chances of winning approval for the level of spending his committee seeks and for taking the highway funds off-budget appear slim. Says Kathy Luhn, director of government affairs for the National Industrial Transportation League, "We agree that the highway funds should be off-budget, but it's not going to happen." Still, she commended Shuster for his efforts. "He stuck to his guns," she says, "but political reality is against him."


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Dad, discover how you can affirm your daughter for her inner beauty. She needs that from you. read more
Charisma Magazine
Page 41 of 77
How to Live as Sons and Daughters of God
Are you still living your life as an orphan or slave to the enemy? Or are you living as Christ's adopted child? read more
What You Don't Know About 'Duck Dynasty'
Duck Dynasty has become a national phenomenon. It's about the power of family, the power of forgiveness, the power of faith—and a whole lot of humor, to boot. read more
3 Maturity Lessons for Young Men
Discover how "thinking different" can make a difference in every man's life. read more
7 Traits of Kids With Good Character
As parents, we want to see our kids develop strong character. Discover what we need to show them in our lives to make that happen. read more
Do You Possess Self-Esteem or God-Esteem?
Discover why Christians sometimes find it difficult to receive God's unbelievable gift of grace. read more
How to Overcome Negative Thinking
Proverbs 23:7 says, "As a man thinketh in his heart, so is he." Discover how your thought patterns ring true in your life. read more
4 Ways to Overcome a Spirit of Terror
Your heart races, your muscles are clinched and regrets are probably running through your mind. That's not God. Find out how to put an end to the terror. read more
Do Your Actions Show That You Care?
Discover how one simple act of love and compassion can make a lifetime impact. read more
How to Repel an Attack of Lust From the Enemy
Discover how Jesus' temptation wasn't any different from our own and how He fought off the enemy. read more
6 Things Your Friends in Crisis Wish You Knew
Whether you have a friend who just lost a job, went through a divorce, or is dealing with a chronic ...
4 Ways to Test if God Is Calling You
Here are 4 tests to determine if God is calling you to a certain task or ministry.
When Church Becomes a Soap Opera
How do you respond when you find yourself in the middle of church drama?
The Osteen Predicament: Mere Happiness Cannot Bear the Weight of the Gospel
Is Al Mohler being too harsh with the Osteens, or is he dead on?
Discerning the Progressive Applications of Your Prophetic Revelations
Sometimes you have to grow into your prophecies, while your prophecies grow in you.
5 Things You Need to Know About Speaking in Tongues
The truth behind one of the church's greatest controversies is boldly stated throughout ...
4 Wicked Ways the Enemy Puts You to Sleep
Paul clearly warned us not to be ignorant of the devil's devices. Jennifer LeClaire unveils ...
Where True Intimacy Starts in Marriage
Teresa Shields-Parker thought her issues with intimacy were caused by her weight. The Holy Spirit ...
Prophetic Prayers for the Middle East Crisis
As conflicts in Iraq, Syria, Iran and Israel heat up, James W. Goll says we're in the final ...
Spiritual Adultery and Fornication in the 21st-Century Church
What some were calling "deeper truths" in the early church, Jesus said were the depths of ...
How to Legally Study the Bible in Public School
Despite an onslaught of threatening lawsuits attacking the most benign of personal religious ...
Why Pastors' Wives Misbehave
We may forget that our pastor's wife is human. Here's why we need to let her be who God ...
Should Christians Celebrate the Feasts of the Lord?
What's the relationship between Christ's new covenant and the Old Testament Jewish ...
Franklin Graham: Are We in the Last Hours Before Christ's Return?
There appears to be no end to the bad news.
The Islamic Ghost That Haunts Obama
Is the U.S. president's Muslim background getting in the way of his duties to protect the ...
7 Points to Help John Kerry Defend Islam
John Kerry's recent news-conference speech supporting Islam has raised some really poignant ...
Keeping the Shemitah Produces Supernatural Results
When a banana farmer in Israel finally resolved to observe the Shemitah, the miraculous happened.
Are You Easy to Offend?
In Luke 17, Jesus warned that offenses will come. Here's how to handle offenses in a ...
5 Unfair Expectations of Your Husband
It's the ladies' turn. What are some of the unreal expectations you've had with your ...
In 3 Months, This Man Became Cancer Free
Here's what Russell Pyle did immediately after being diagnosed with bladder cancer and what you ...


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Sierra backpacking: Ansel Adams Wilderness
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Jeff Winter, his brother EJ and L.A. Times photographer Ken Hively head to the Ansel Adams Wilderness in California for a backpacking adventure. They've been taking backpacking trips nearly every year for the last 35 years.
Formerly the Minarets Wilderness, it was expanded and renamed the Ansel Adams Wilderness as a result of the Wilderness Act in 1984.
|Reporters and editors involved in creating and writing these cruise articles are in no way affiliated with any links that are placed on the pages. Read our full editorial policy.


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On the first anniversary of President Barack Obama's climate change speech, the White House hosted a billionaire environmental activist on Wednesday. Read more
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Sept. 2005 in Berkeley. Displaced by Hurricane Katrina, brundlefly was welcomed to California with the requisite amount of Metafilter snarkiness. He has stayed in the Bay Area since then as an independent filmmaker.To me it's the most Metafilter-ish photo I have: one part important/interesting occurance, one part community, and one part snark. Alas, the NYT wouldn't print the word "fuck". C'est la vie.
"I think that, when given a chance to use one's real name (or some close version thereof) or to rename oneself, the natural inclination of humans is to do the latter."posted by grouse at 1:47 AM on September 30, 2007
Really? Why do you think this?
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Andre de Guisti is an energetic 2-year-old with a new hope for walking. Doctors told his parents the little boy may not ever be able to walk and they wanted to amputate his legs.
But a remarkable journey brought the family more than 8,500 miles from South Africa to Saginaw, Mich. to seek treatment for their son's legs.
Nearly two years after an operation, Andre is back for a check-up.
Little Andre was born with dislocated hips and problems with the tendons in his legs. Doctors in South Africa never even gave him an X-ray -- they told his parents there wasn't much hope.
"Every doctor you went to had kind of the same story or a worse scenario," said de Guisti.
The family met a doctor from Saginaw while he was on a safari. That doctor put them in touch with Covenant Healthcare and ultimately a doctor who could perform the necessary operation.
Dr. Anthony Debari performed the operation on then-6-month-old Andre.
"It's very cool, you know he's not perfect but at least he's up walking with a walker now, probably with some crutches when he gets older," said Debari.
Part of Andre's therapy includes swimming and horseback riding. He turns 3 in February.
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Lewiston, ME—The Portland Pirates host the St. John's IceCaps for the second time this week in a matinee at the Androscoggin Bank Colisee in Lewiston. Puck drop is set for 4 PM for the 8th of 12 meeting between the two teams. St. John's leads the season series 6-1.
The Pirates dropped Game 8 of the VIP Cup Series, presented by VIP Tires & Service, last night in Manchester 5-4. Portland had a leads of 2-0, 3-1, and 4-2, but were unable to hold on as the Monarchs scored three unanswered goals in the third period. Andy Miele registered his 100th career assist in the first period, while Brandon McMillan tallied 2 goals and an assist in the loss. Manchester leads the VIP Cup series 6-2 and clinched at least a share of this year's title with their win last night. For more information on the VIP Cup, please visit www.vip-cup.com.
St. John's is undefeated in regulation in their last 4 games, including two straight victories over the Worcester Sharks this weekend. The IceCaps defeated the Sharks 5-1 on Friday night and 3-1 last night, with Michael Hutchinson making 49 saves for the win. St. John's' Kyle MacKinnon had a three point Saturday for the IceCaps, who currently sit in 6th place in the Eastern Conference with 66 points.
The Pirates and IceCaps last played Tuesday, a 7-5 win for St. John's. The Pirates jumped out to a 2-0 lead but the IceCaps stuck back with 6 goals in the second period, the most goals that the Pirates have allowed in a period in team history. The Pirates made the game interesting in the third as Lucas Lessio and Brett Hextall both scored, but they were unable to overcome the deficit. Lessio scored twice in the game and added an assist, while Andy Miele scored his 20th goal of the year, setting a career high.
KeyBank Key to the Game
60 Minutes: The Pirates have allowed comebacks of 2 goals in each of their last two games and need to play a full 60 minutes this afternoon to get the win. The Pirates' defensemen will need to step up to help with this effort, as Pirates opponents have put 86 shots on net over the past two games, with 24 of those coming in the third period.
Tonight is Androscoggin Bank Mobile Banking night – make sure to stop by their table in the Colisee lobby and check out their display!
The first 500 fans through the doors at tonight's game will receive an Electricity Maine winter hat! For more information about the Electricity Maine Hat giveaway, click here.
This afternoon's game can be heard on the Pirates flagship stations WPEI 95.5/95.9 FM as well as WEZR FM 105.5/AM 1240 in the Lewiston/Auburn area and WTME AM 780/1450 in Oxford County. The game can also be heard online at portlandpirates.com by clicking "Listen Live" and can be seen live on AHL Live at ahllive.com. The pregame show starts at 3:40 with Jeff Mannix. Tickets are available at the Androscoggin Bank Colisee by calling 783-2009 ext. 525 or online at thecolisee.com.
Follow all the action on the Pirates official Facebook page and Twitter account (@PortlandPirates) with the hashtag #PiratesHome.
Season tickets for the 2014-15 season are now on sale as the Pirates return to the Cumberland County Civic Center! Choose the 5 on the Fly, Salty's 16, or Captain's Full Plan, all with great benefits! For more information on season ticket plans, visit www.portlandpirates.com/tickets/season or call 207-828-4665.


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Patients with melanoma often require specialty services during the course of treating and managing the disease. The Melanoma and Pigmented Lesion Clinic at Rush University Medical Center in Chicago involves physicians and specialists from divisions that are integrated in the care of melanoma patients. Practitioners from surgical oncology, medical oncology, radiation oncology, dermatology, radiology, pathology and integrative medicine work collaboratively to provide the best individualized care for patients and their families.
Dermatologists, medical oncologists and surgeons at Rush examine patients for early signs of malignancy or premalignant lesions. Moles and other suspicious lesions are photographed by a medical photographer for further comparison and for patients to use in self-examination.
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Snowflakes 'falling' for Sandy Hook
Local children and adults are invited to make paper snowflakes from noon-4 p.m. Sunday, Dec. 30, on behalf of the surviving children and teachers at Sandy Hook Elementary School in Newtown, Conn.
When school resumes for Sandy Hook, it will be in a new building. Parents and volunteers are working to ensure that the students are welcomed back by "a winter wonderland" with the entire school decorated with as many unique snowflakes as possible.
Sequim's snowflake making project will be at 135 Fairway Drive in Sunland (door on left next to parking lot).
Bring left over food goodies, scissors and any craft supplies such as paper, glue, glitter, sequins, etc. Organizers will have a selection of scrapbook paper and adhesive spray.
RSVP to Virginia Johnson at 582-9177 or firstname.lastname@example.com or Lynn Bender at 360-797-1540 email@example.com if you are interested in attending or helping with this project.
Donations also will be accepted to the Sandy Hook Elementary School PTA.
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D.C. students could learn how to be taxi drivers or repair streetcars through programs proposed for Spingarn High School, which is scheduled to be closed as a traditional school in June.
These two programs are part of a career and technical education center that DC Public Schools plans for the Ward 5 high school after it closes. The center will focus primarily on preparing students for careers in transportation and health care, officials say.
"We're currently working toward the goal of training students for high-demand industries," said DCPS spokeswoman Melissa Salmanowitz. "We continue to work closely with other agencies, like DDOT, to ensure we're serving our students and helping prepare them for future careers."
One of the more developed programs will teach mechanical and electrical repair skills in partnership with the under-construction
D.C. streetcar line, said Pedro Ribeiro, spokesman for Mayor Vincent Gray. Since the line's car barn will be just south of Spingarn, students will be able to gain practical experience.
Students who complete a proposed taxi course would be able to get certified to drive taxis in the District immediately after graduating, said DC Taxicab Commission Chairman Ron Linton, who said he has been in discussions with DCPS Chancellor Kaya Henderson about the program.
In addition to the taxi and streetcar courses, DCPS also hopes to offer an information technology course, Salmanowitz said. She said she did not have any details on the courses since they are still being developed.
These kinds of "career academies" are becoming more popular across the country as more evidence shows they can lead to student success, said Russ Whitehurst, director of the Brookings Institution's Brown Center on Education Policy. "There's really a renewed interest in providing students who probably are not going to go to college with something that's worthwhile."
The good programs teach students the skills they will need to succeed in careers that really exist in the cities where the courses are offered, he said. "It's not just preparation for a permanently low-end job," but something that leads to a middle-class income, like experience working as an aide in a health care setting.


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With the high tourist season almost upon us, South Florida is gearing up for the international visitors and big events that have lifted Miami's reputation from a sleepy retirement town to a world-class gem that attracts billionaires from as far away as Japan to come view the latest exquisite pieces at Art Basel or to take a cruise to the Caribbean.
But those visitors still have to navigate Miami International Airport and PortMiami, and it is those first impressions that can make or break our future as word spreads about lousy cab rides — no air conditioning, no ability to pay with a credit card, in essence, bad service.
On Tuesday, Miami-Dade County commissioners have an opportunity to end the old ways and usher the taxi industry into the 21st century — and to send a signal to international investors that Miami is serious about improving urban mobility, whether it's Car2Go, where you can rent a car by the hour, or services like Uber or Hailo, which offer a computer app for cell phones to order a Town Car.
Commissioners will have four proposals before them:
• The Ambassador Cabs Program, proposed by Miami-Dade Mayor Carlos Gimenez and sponsored by Commissioner Jose "Pepe" Diaz, would raise the bar for those cab drivers who want to pick up passengers at the airport or seaport. They would have to carry credit-card, GPS and SunPass devices and digital security cameras. It would fine cabs that refuse to pick up visitors or their bags or who overcharge. It also would have a dress code for drivers — a shirt with a collar, not a T-shirt, please — and require that vehicles not be outdated jalopies.
• A credit-card or debit-card requirement, proposed by Commissioner Juan Zapata, also is on the agenda. It would offer a cash discount to passengers who prefer to use cash, which gives drivers who complain about paying a credit-card transaction fee some wiggle room. But be warned, cabbies, the payment method has to change to catch up to every other major city where taxis offer credit-card payment. Besides, it's safer for drivers to carry card receipts than cash.
• Commissioner Dennis Moss is proposing a fine for cab drivers who overcharge — a common complaint by visitors and residents alike. The airport's new director Emilio Gonzalez says his office often gets those complaints.
• The expansion of sedan service, the so-called "black cars" or Town Cars would be welcome news for visitors who right now have to wait an hour after hailing such a high-end car because rules require the wait. It's time to bust up that monopoly. Commissioner Audrey Edmonson wants the county to offer passengers a quick service at their finger tips through the Uber app. She's right. The county simply has too few Town Cars. Instead of setting a cap on licenses, the county should require quality standards for the cars (already regulated for safety) and let the market — and not government — dictate demand.
Many taxi drivers argue they can't afford to offer credit cards, and that expanding the sedan service would be "unfair." Those arguments fall flat. Any business person understands that to grow you have to invest.
As Miami's reputation as a world-class destination takes root, commissioners must embrace the type of innovations that will help attract high-tech start-ups to the region. Instead of falling into the monopoly trap and continuing to erect regulatory barriers to innovation, it's time for Miami-Dade to move forward — and quickly.


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Parents pay sitters directly.
But drawing sitters to these sites may have been the easy part. The largest roadblock to success has been user confidence.
"Since finding child care is an extremely trust-based decision, some parents had reservations going online because they were accessing a network of 'strangers,' " said Melissa Marchwick, a spokeswoman for Sittercity, created in 2001. But she said through background checks, bios and a recommended screening, "parents often end up with much more information about who they are hiring through Sittercity than if they had found the individual through their personal network."
Together, the two sites attract about 2.6 million unique visitors each month, according to the website analytics firm Compete.
Still, there have been a few disasters. A California man who advertised on both Sittercity and Care.com was charged in 2011 with molesting two boys he was paid to babysit.
"It's not foolproof," said Adam Koopersmith, a partner with New World Ventures, which has invested millions in Sittercity. "We're playing a matchmaking service. You still have to do your references and your work. We help provide guidelines and questions to ask and how to try and prevent some of this stuff from happening. And I think the vast majority of folks who work with Sittercity have great outcomes."
It's the idea of being in the unfortunate minority that can be mortifying.
"It's a little terrifying at first," said Silvia Zavala Garcia-Serra, a 35-year-old stay-at-home mom who lives on Key Biscayne with her attorney husband and daughter, 2.
Garcia-Serra said she used a local franchise of Seeking Sitters for the first time a year ago after the sitter she trusted with her baby moved back to Mexico. A friend told her she knew a company representative and said that the service screens and backgrounds its sitters. Longing for a night out, and with her lone South Florida family member living in Doral, she gave it a shot.
"I think I called the owner like five times when I was having dinner," she said. "Are you sure she's not going to kidnap my daughter? You know where she lives right? You have a current picture?"
Now she uses the site regularly.
As more parents are willing to consider the Internet to source sitters, and more are won over, local options are increasing. In Miami, that includes TLC for Kids, which came to Miami in January after 20-plus years operating in St. Louis, and MiamiBabysitters.net. Parents can also turn to Just Ask Boo, and Florida Atlantic University, to name a few sources.
Some of these services go by the marketplace model. Others, like TLC for Kids, are more like nanny services that have adapted to the Internet.
Co-president Sharon Graff-Radell argues that a service that sends its own employees is the better model, because companies like hers are liable for damages and therefore are sending employed sitters who have been vetted more thoroughly. She said sites that register millions of sitters may not catch everyone who has a red flag in their background, or who isn't qualified to watch kids.
"The problem with these online sites is people have a false sense of security," she said. "They're Internet companies. They're not child-care companies. They're the Amazon.com of child care."


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Jeff Guin
Jeff Guin is currently Manager of Emerging Media at Chemical Heritage Foundation. At NCPTT he managed public affairs and marketing until October of 2011. In 2006, he initiated the National Center's social media efforts, making NCPTT one of the first preservation organizations to use these tools to connect to its audience. Jeff received his Master's degree at Northwestern State University in 2002.
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Fulton County District Attorney Paul Howard says his life has been threatened. He made the revelation on Friday to explain why he decided to use public funds to pay for security upgrades to his property.In a press conference on Friday, Howard displayed threatening letters and talked about warnings from the FBI that detailed assassination attempts. Howard said he revealed details of the threats to answer questions about his decision to use a forfeiture account collected from criminal assets to pay for an iron door at his home. He said that he ordered the purchase for security rather than ask for a law enforcement officer to be at his property around the clock for protection. "These security measures were not only provided to me, but to two other employees within my office whose assignments often bring them in to real danger," Howard said. "As you know, a district attorney and his wife were brutally murdered in Texas, and the murder took place in the district attorney's home."William Perry of the government watchdog group Common Cause Georgia said that forfeiture cash, while not taxpayer dollars, are public funds. He questioned Howard's use of the account, not as much for the security purpose, but instead the fact that Howard also ordered that thousands be spent in donations to non-profits. "I think donations to charities and things like that certainly do benefit the charity with funds, but it also benefits the individual in terms of publicity and things like that," Perry said. That sounds more like it should be a campaign expense, not a public dollars expense. "Howard, who took no questions from reporters, said that his goal with the donations is provide help for people through organizations that do good things for the community, instead of just locking people up.
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