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Thirteen people were shot Thursday night in Back of the Yards when two gunmen opened fire on a group watching a basketball game at Cornell Square Park. A 3-year-old boy was shot in the face.
Chicago Police Superintendent Garry McCarthy said that the gunman fired at least 16 rounds from a 7.65 rifle. Law enforcement sources tell FOX 32 News the casings found would have been fired by an AK-47--either a long barrel assault rifle or a modified pistol version.
On Friday afternoon, just a mile and a half away from the shooting scene, police made a disturbing discovery: an assault rifle dumped in a trash can. Police have not confirmed if the weapon found is in fact the one used in Thursday's shooting.
McCarthy did say, however, the incident was a gang-related shooting.
"There was a basketball game going on," McCarthy said. "The park is open until 11 p.m. We have a policy where the beat officers go into the park and shut it down."
Since the shooting took place at 10:15 p.m. Thursday, park visitors had at least 45 more minutes to enjoy the warm night. When the shots rang out, the group scattered, taking cover wherever they could.
Julian Harris, 22, said his 3-year-old nephew, Deonta "Tay-man" Howard, was shot in the face.
SPECIAL: Chicago at Tipping Point - Violence in Chicago
Deonta was taken in critical condition to Mount Sinai Hospital. Semecha Nunn, the boy's grandmother, said Friday that he's "doing better" and is "very strong" after having plastic surgery.
Harris said dreadlocked gunmen in a gray sedan fired at him at the corner of Wood and 51st before turning north on Wood and shooting up the park. According to other witnesses, two gunmen got out of the car and began shooting.
"They hit the light pole next to me but I ducked down and ran into the house," Harris said. "They've been coming round here looking for people to shoot every night — just gang-banging stuff. It's what they do."
McCarthy also said given the type of weapon used, it is "a miracle there were no fatalities."
The police superintendent said investigators believe several people were involved, but that it wasn't clear yet whether more than one person opened fire. He said based on witness interviews, it appears the attack was gang-related and that several victims are gang members.
"We don't have anybody that I would call in custody at this point," McCarthy said. "We are interviewing people. We're going to come to a quick conclusion on this, as we have with other high profile cases as well."
The young boy's aunt, 18-year-old Lavada Hardeman said her brother was killed on Labor Day.
"I can't catch a break," Hardeman said.
The 3-year-old's uncle, Jerome "J Money" Wood, a rapper who was affiliated with Def Jam artist Durk "Lil Durk" Banks, was shot in the head and died on Sept. 2 in the 6600 block of South Rhodes in the Woodlawn neighborhood.
Corey Brooks, pastor of New Beginnings Church on the South Side, presided over Wood's funeral. He said he was called early Friday to again comfort the family at the hospital.
"They're frustrated, upset and hurt and disappointed that this is just happening over and over and over in our community," Brooks said.
Brooks said the bullet passed through Deonta's face, but did not cause brain damage.
"The family's all here. They're pretty distraught," said Brooks, adding that he does not think the shooting was connected to Wood's death.
"Senseless and brazen acts of violence have no place in Chicago and betray all that we stand for," Mayor Rahm Emanuel said in statement Friday morning.
SEE: Emanuel calls Chicago shooting 'senseless and brazen'
He said the criminals will be brought to justice and prosecuted to the full extent of the law.
"I encourage everyone in the community to step forward with any information and everyone in Chicago to continue their individual efforts to build stronger communities where violence has no place," Emanuel said Friday.
Brooks also urged the gunman to turn himself in. He told FOX 32 News that witnesses got a very good look at the shooter's face, and that they know who he is. Brooks fears that retaliation is a very real possibility and said the suspect will become a shooting victim himself if that happens.
At the scene of the shooting, a woman identified by family as the 3-year-old's grandmother — who is the slain rapper's mother — lashed out at police, yelling, "You . . . . cops can't solve s - - -."
Family eventually persuaded her to climb into an SUV waiting to take her to the hospital.
Harold Hall, a community activist whose own son was killed by gun violence 9-years ago, told FOX 32 News on Friday that his neighborhood hasn't seen the amount of police coverage other neighborhoods have received.
"The fact of the matter is that it appears that they can't help us, the police. People talk about the National Guard… Actually I'm in favor of someone coming here to save our children," Hall said. "People down in Springfield are talking about their checks when they really ought to be out here on ground zero with us to combat this problem."
"This is not a black problem," Hall said. "This is a human problem."
Neighbors around the park marveled at the sight of dozens of police and described how their evenings were interrupted by the staccato sound of gunfire. Neighbors said they dove to the floor for cover in their homes.
A 13-year-old neighbor said she was in her living room across the park when she heard multiple shots. "I got down because I was scared," she said in Spanish.
"Now I'm scared after seeing this," Claudio Patino said in Spanish. "I haven't seen this ever. This is the first time."
Kevin Green, 50, said he saw multiple injured victims being taken away on stretchers.
"The women were crying and screaming," he said. "It was wild."
Francis John, 70, was upstairs in her three-flat near the park when she heard gunfire: "It was a lot of boom, boom, boom."
When she went outside to see what had happened, she said she saw "a lot of youngsters running scared."
John, who said she has lived in the neighborhood since 1983, was surprised by the shootings Thursday night. During her 30 years in the area she has seen the neighborhood go from good to bad, to better in recent years.
"We were surprised. People are watching the community," John said, referring to neighborhood watch efforts. "I thought [the shootings] were over. But despite this incident, it's not as bad as it used to be."
McCarthy said weapons like the one used in the attack belong on a battlefield, not on American streets.
"It's unusual in a civilized society that something like this could happen," McCarthy said.
SEE: McCarthy says assault-style gun used in attack
He adamantly said "real action" on new laws is necessary to restrict such weapons, to require better background checks and make it mandatory for gun transfers to be reported – including those lost or stolen. He said this would help curb the number of illegal weapons in Chicago.
"Illegal guns. Illegal guns. Illegal guns drive violence," McCarthy said.
Chicago's homicide numbers made national headlines once again on Thursday, as FBI crime statistic from 2012 determine the city to be the murder capital of America. Although the number of murders in Chicago are lower for 2013, the battle against violent crime continues.
"Every shooting is a setback in the city's battle against violent crime," McCarthy said. "Every resident of this city should feel the same sense of safety and security."
McCarthy said police will work until this is accomplished.
Police listed the victims as:
The Sun-Times Media Wire and Associated Press contributed to this report.
Follow @fox32news
25 FOX DriveDedham, MA 02026
Phone (781) 467-2525


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Democrat Terry McAuliffe will be the next governor of Virginia after a tight gubernatorial race.
NBC News, Fox News, CNN and the Associated Press called the race for McAuliffe less than three hours after the polls closed statewide.
McAuliffe trailed early before finally taking the lead when 91 percent of the vote was tallied. Republican Ken Cuccinelli lost by less than two percent, despite polls putting him at a substantial deficit heading into election day. Libertarian Robert Sarvis garnered seven percent of the vote, leading many pundits to believe his showing swayed the outcome of the election.
"Despite being outspent by an unprecedented $15 million, this race came down to the wire because of Obamacare," Cuccinelli told supporters during a concession speech around 10:30 p.m. to a crowd at the Downtown Marriott in Richmond.
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An Arkansas State player tried to distract the opposition in an unusual way Saturday - by faking his death.
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Fairfield District Supervisor Thornton to hold meeting at Eastern Henrico Rec Center
September 24 2014 - Topic: update on voting requirements, 7 p.m., Free
Innsbrook After Hours to present Big Head Todd and the Monsters
September 24 2014 - Gates open at 5 p.m., 6 p.m., $15 to $20
Chickahominy YMCA to present the Hot Spot program 'Snappy Grown Ups'
September 24 2014 - Hot Spot events and activities are open to the community for active older adults age 55 and older, 11 a.m.,
Commonwealth Parenting to present 'When Time Out Doesn't Work' for parents of toddlers
September 24 2014 - Children's Museum of Richmond-Short Pump, 6:30 p.m., $30
UR Modlin Center to present Marc Broussard, special guests at Alice Jepson Theatre
September 24 2014 - Mix of funk, blues and passion entwined with distinct Southern roots, 7:30 p.m., $18 to $36
Deep Run Park to host 'Picnic in the Park'
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Build marble runs from recycled materials at Dumbarton Library
September 25 2014 - Suggested for ages 7-10, 3:30 p.m.,
Chickahominy YMCA to offer a Hot Spot program on Tai Chi
September 25 2014 - Hot Spot events and activities are open to the community for active older adults age 55 and older, 10 a.m.,
Wilton House Museum to present 'A Georgian Folly for the 21st Century'
September 25 2014 - Presented by interior designer, architect and preservationist Ralph Harvard, 6 p.m.,
Belmont Golf Course to host the Star Spangled Scramble
September 26 2014 - Benefits the Wounded Warrior Project, ,
Lions Club donates backpacks to elementary school
Above, club members display some of the backpacks prior to their distribution. > Read more.
Glen Allen student to perform at Carnegie Hall
At the first-place winners recital in Weill Hall, Matija will perform Giacomo Puccini's opera aria, "Chi il bel sogna di doretta." She will perform with other vocalists from around the world and have the opportunity to win other awards and scholarships.
Locally, Thomas has performed with Richmond's renowned Glorious Christmas Nights, Christian Youth Theatre, and WEAG's Urban Gospel Youth Choir. > Read more.
Gayton Baptist Church dedicates new outreach center
The John Rolfe YMCA and Gayton Baptist Church have partnered in an effort to bring greater health and wellness opportunities to the community.
Through this partnership, the John Rolfe Y will run Youth Winter Sports programs, including basketball and indoor soccer, in Gayton's newly renovated $5.5 million outreach center that features a new gymnasium, youth and teen space, social space with café, meeting space and full service commercial kitchen. > Read more.
Page 1 of 118 pages 1 2 3 > Last ›
New Henrico biscuit shop thrives with grandmother's recipe
Laxton opened Early Bird Biscuit Co. & Bakery in early July and since then biscuits have been flying out of there.
The self-taught baker draws hungry crowds in with a biscuit of the day like the Old Bay Cheddar, but the buttermilk biscuits are the staple.
"On a Saturday I generally make about 400 biscuits with my two hands," Laxton said. "I'm constantly making biscuits all day long." > Read more.
Restaurant watch
CAT Theatre announces cast of Sherlock Holmes play
The plot follows what seems to be the end of the career of the world's greatest detective as he is confronted with a case far too tempting to ignore. When the King of Bohemia faces blackmail by famed opera singer Irene Adler, Holmes and his faithful companion, Dr. Watson, find themselves falling into the trap of evil genius Professor Moriarty. As Holmes says, "The game is afoot Watson, and it is a dangerous one!" > Read more.
Totty named director of Henrico MH/DS
Moving on up
TSA workforce donates one ton of food to Central Va. Food Bank
Henrico Police make arrest in West End shooting
Glen Allen Day scheduled for Saturday
Sep. 18, 2014Click here to read the print edition.
New Henrico biscuit shop thrives with grandmother's recipe
Restaurant watch
CAT Theatre announces cast of Sherlock Holmes play
Extras sought for AMC's 'TURN'
Weekend Top 10
Obituary – Susie Ann Walker
Obituary – Philip "Al" Cebulski
Obituary – Cecelia Davis Stevens
Lions Club donates backpacks to elementary school
Glen Allen student to perform at Carnegie Hall
Gayton Baptist Church dedicates new outreach center
The Citizen at 13
Peeling off the labels
A messy food fight
Hermitage to host Monday night football events
Down to the wire
Babe Ruth 13U World Series arrives in Glen Allen
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ClassifiedsATTENTION DIABETICS with Medicare. Get a FREE talking meter and diabetic testing supplies at NO COST, plus FREE home delivery! Best of all, this meter eliminates painful finger pricking! Call… Full text
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Delorean Paul says after his cousin was dropped off at a bus stop at West Wilson and Motor Street in Pontiac on Wednesday, he was approached by a man armed with a gun, who tried to kidnap the little boy as he walked to his home less than a block away."I guess he approached him... grabbed him, put his hands on him, and my cousin shook loose, and he got away from him, and he ran home and screamed for help," Paul explained.We're told the boy's father ran out to look for the man, but he was gone.The child told detectives with the Oakland County Sheriff's Department the man flashed his gun, grabbed his arm and told him to come along, but the boy thought fast and was able to slip away from the man's grip and get away.The suspect is described as a thin black man around 20 years old wearing a white sleeveless T-shirt and blue jeans."He's fine. He was a little shook up," Paul said.The child said he did not recognize the suspect, but detectives say after talking to neighbors, two of them said they did see a man matching that description about two hours before this allegedly happened.If you have any information, you are asked to call the Oakland County Sheriff's Department.
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NEK Adventures gives you the opportunity to see Vermont sights that most will miss traveling by car. Sceanic vistas, animals in their natural habitat, and the unspoiled beauty of Vermont's farm land.
If you are looking for a leisurely scenic tour NEK Adventures is for you! Check out our website and find us on Facebook!!!
We also offer snowmobile tours and Rentals in the winter months!
Call or email to book your tour!
2 Hour Private Family Tour: $250
Includes 2 ATV`s & a stop at an ice cream shoppe. Family package consists of Two adults and two children 15 years and under. Additional ATV`s/riders will be an additional fee. Subject to availability.
Two ATV minimum. Children under 10 free. Includes helmet, registration, and trail pass. Does not include tax.
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Shelburne Vineyard Winery and Tasting Room
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Taste! Tour! Enjoy! Visit our Shelburne Vineyard Winery and Tasting Room, in the heart of the Champlain Valley, just minutes from downtown Burlington. Open daily 11-5....
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Scenic Vermont train ride along the majestic Conneticut River in our vintage coaches. 2 hour round trip and option to stop at Montshire Museum. Holiday and family events for all ages and group rates available. Check web for more!...
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Inn at Baldwin Creek & Mary's Restaurant
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1500 feet of beautiful beaches, priceless lakeshore views provide an exceptional setting for 200 campsites both wooded and open. Swim, hike, bike or just relax by the lake, you will find all the amenities you need for great family fun....
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Bollmann Alternative Case with shoulder straps, Blue
- Manufactured in lightweight and tough polymousse
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- Dimensions 40cm L x 36cm H x 24cm W
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Holiday Indoor Hat League 2011
- Details
- Category: Hat Leagues
- Last Updated on 05 December 2011
Registration went active at 5:00PM on Monday, September 26. Links to "Sign up for Holiday Hat League 2011" are available on your Player's Page, linked in the right-hand column.
Teams have already been created, so if you want to get on the short waitlist, contact us using the email at the bottom of this page.
If you do not have a waiver on file for 2011, please print one from your Players Page and either fax or mail it in. (The fax number and address are on the waiver.) In order to register, you must complete the waiver, which can take a few days for BUDA to process.
Players sign up as individuals and get assigned to teams. Players can only sign up with one other partner. Teams should be announced by October 31st.
Natural Disasters
Northborough section
Revere section
|Teamworks Northborough
185 Otis Street, Northborough, MA 01532
Create your own Google Maps directions
|Teamworks Revere
321 Charger St, Revere, MA
Create your own Google Maps directions
|* Wednesdays
* November 9 through February 1 (excludes Nov.23 and Dec.28)
* 11 weeks, one 90 minute game per week, sometime between 8pm and 11pm
* Final 3 weeks are playoff weeks, so those schedules only comes out 5-6 days in advance. All teams participate in all 3 games of playoffs.
* 4 teams
|* Sundays
* November 6 through January 29 (excludes Dec.25 and Jan.1)
* 11 weeks, one 90 minute game per week, sometime between 2pm and 8pm
* Final 3 weeks are playoff weeks, so those schedules only comes out 5-6 days in advance. All teams participate in all 3 games of playoffs.
* 8 teams
|Weather cancellation policy
|Teamworks does not close due to any weather conditions. Therefore, BUDA does not plan to cancel any games. Travel at your own discretion. If there are not enough players and subs on a team because of travel conditions, strongly consider recording the score as 1-1 to be fair.
|Teamworks does not close due to any weather conditions. Therefore, BUDA does not plan to cancel any games. Travel at your own discretion. If there are not enough players and subs on a team because of travel conditions, strongly consider recording the score as 1-1 to be fair.
|Arena and Foorwear
|A 185x85 foot indoor soccer field with high quality turf, meaning you can wear plastic cleats. Metal spikes are not allowed.
Note: Revere Teamworks does not have a lost and found. They throw everything away. So if you see stuff from the previous team, help out by taking it with you and having captains contact each other.
|After-game Restaurants
|Though not a sponsor, Teamworks Northborough has a restaurant and bar on site that overlooks the indoor fields.
Our semi-sponsor is Uno Chicago Grill (mobile link) of Revere, just down the street!
With a minimum of 6 BUDA players, they are offering free mini-appetizers for each player. Just let them know that your group is part of the BUDA Ultimate Snack Hour Party.210 Squire road, Revere, MA 02151
Directions from Teamworks
Indoor ultimate is played just like regular BUDA hat leagues with the following differences. The usual Winter Indoor Hat League rules are basically in effect except for the pulls, substitutions, and an extra timeout.
- To increase play time, games will run continuously in a two-pull game: one at the start and one at the half. After a point is scored by a team, that team puts the disc on the ground. Then, the team that was scored on starts the next point on offense by "putting the disc into play after a point is scored" (defined below). This means that your team will only head for one end zone in the first half and only head for the other end zone in the second half.
- As each point is scored, substitutions on both sides can be "initiated" until the disc is put into play. To be "initiated", substitutions must start heading for the arena door with one arm raised before the disc is allowed to be put into play. While leaving, they cannot participate if the point starts. Replacement players can enter and participate immediately upon initiation of a substitution, even if the person leaving the arena is not off the field yet.
- For the purpose of this league, "putting the disc into play after a point is scored" consists of the following:
- Starting from when the score was made, this whole process should take about 10 seconds to allow for substitutions to be initiated while maximizing the speed of play.
- The handler picks up the disc and brings it to the end zone line nearest to where it was picked up.
- The handler and marker must both verbally agree that their teams are ready to play. Failure to make this agreement is a violation.
- The handler must establish a pivot point at the spot nearest to the end zone line and touch the disc to the ground so that all players can see that the handler and marker agreed that their teams are ready to play.
- Waiting too long to put the disc into play is considered "delay of game" and the usual USAU rules are in effect for starting a stall count. That is, a defender within 10 feet of where the disc is to be put into play can initiate the stall count if audible 10 and 5 second warnings are announced. As an additional rule to prevent the marker from delaying the game, the handler can also give audible 10 and 5 second warnings before declining the marker's privilege to agree that the defense is ready. Also, by initiating a 10 second warning, you are establishing that you are "in agreement" and ready for your opponent to agree.
- Stall count is to 7.
- Contested stalls go back 2 seconds, just like USAU rules.
- Fouls over 5 seconds that USAU rules bring back to 6 seconds should be brought back to 4 seconds instead.
- Male/Female Format is ideally 4/1 or 3/2 offense calls, but historically, this has proven difficult. Therefore, the league is open (no required gender ratio), but teams should make their best effort to field at least 1 woman per point. Of course, captains can always agree to differences.
- Timing: Half time and final score are determined by time instead of score:
- Play time starts exactly on the scheduled hour.
- 5 minutes of warm up. It can be shorter by agreement of the captains.
- Start the game at 5 after the hour.
- First half is 40 minutes (25 minutes for a 1 hour game). At the halftime buzzer, play until the point is scored.
- Halftime is at most 5 minutes. It can be shorter by agreement of the captains.
- Second half plays right to the end of the hour. Tip: for a 90 minute game, set up the scoreboard for 90 minutes and just remember to start at 85, half at 45, game over at 0.
- Game ends at the final buzzer even if the score is tied. That is, just like basketball, the last throw must be made before the buzzer starts (or before the time expires if the buzzer is not enabled). The point can still be caught after the time runs out.
- Recognize that games start and end exactly on time. It's difficult to start the timer at the same time the previous game ended, so be sure to subtract the right number of minutes when setting the timer. All captains have my permission to end a previous game by using the scoreboard buzzer if that game is running over time unless one of the following exceptions applies:
- If the first game starts more than 5 minutes late because a previous league has run over their allowed time, you must receive permission from the front desk for all of our league games to run over the same amount of time. It is the captain's responsibility to pass this information along to captains of subsequent games.
- If there is a foul or violation during the last possession or throw, play can continue for one more throw without a foul or violation.
- During playoffs, if the score is tied, ignore the time and play to the end of the point.
- Each team gets two 60 second timeouts per game.
- Boundaries:
- The walls and net are in bounds, including the soccer goal. Safety reminder: Recognize that the walls are hard surfaces and pose an additional hazard to playing ultimate. Always avoid initiating anyone including yourself from coming into contact with the walls.
- A wall trap is legal since the wall is in play.
- If the disc is trapped against the wall by two opponents at the same time, tie goes to the offense. If there is disagreement about who trapped it first, the disc goes back to the thrower.
- Any disc that comes to rest in the net or between the net and the wall is considered out of bounds. When this happens in an end zone, the disc comes to the goal line.
- The ceiling and/or beams are out of bounds. The disc comes back into play where it landed or at the front of the end zone.
- No foot blocks.
- Endzones are 4 yards unless captains agree to differences.
These rules are the defaults. Captains can always agree to differences.
If you're in need or a ride or want to find a carpool partner, I suggest posting to the HHL forum. If you find a carpool partner, then you'll want to change your HHL application to sign up with that partner to get on the same team. I want to make it clear that changing your application will not effect your chances of getting into the league. However, you must change your application before the registration deadline or else you'll lose the chance to change your partner request.
Visit our HHL forum for questions or to tell us what you think.
If you have questions about the Holiday Hat League, please send e-mail to .
Greg Aloe
BUDA Indoor Commissioner


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The Grant's Office outcomes-assessment process is documented and described below. For more details, view the rest of our department website.
General process currently followed:
- Annually we collect data on productivity including relevant statistics such as number of proposals submitted, number of grants awarded, amount of grant funding awarded, and number of projects receiving post-award support. We also look at the number of departments and personnel involved. Feedback on the process is gathered through the annual evaluation of the Dean of Grants and Resource Development. In addition, we plan to use evaluation surveys to gather more specific data on how to improve our services and processes.
- Gathered data are reviewed by Dean of Grants and Resource Development and staff as well as with supervisor (Associate Vice Chancellor of Institutional Development). These data are analyzed for areas of improvement. Summaries are reported in biannual assessment reports and annually in program review.
- Improvements are implemented in as timely and effective a manner as possible. These improvements are then re-evaluated in the next assessment cycle to ensure they are working and we are continuing to meet our goals.
Administrative Unit Outcomes
These programs areas are on a regular cycle of review, during which outcomes are updated and revised.
Faculty and staff who receive services from us will be able to:
- Recognize opportunities for grant-funded program development and improvement.
- Identify relevant funding sources.
- Secure internal approval for grants and program development.
- Successfully apply for and receive grants.
- Manage active grants including obtaining board approval and managing budgets.


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British Columbia,
Our most popular tours include: Victoria, Tofino, Whistler & the Rocky Mountains.
Our goal is to provide unforgettable experiences at affordable prices & our specialty is delivering the best value. All of our tours include deluxe transportation, an experienced tour guide, sightseeing in each area you visit, discounts on optional activities & more. Check our website for more details.
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News & Blogs
Weather Blogs
Featured Articles
Satellite loops show that a tropical wave (Invest 95L) off the coast of Africa, a few hundred miles southeast of the Cape Verde Islands, has a moderate degree of spin and heavy thunderstorm activity. The wave is under light wind shear and over warm waters of 28°C (82°F), conditions that favor development, but shear will rise to the moderate range, ocean temperatures will cool, and the air surrounding the storm will grow drier by Sunday, making development unlikely.
A unique way that universities can influence the public and political discourse is to develop professional problem solvers, translators who are prepared to break down the barriers created by disciplines and competing interests. These professionals need to take their places in the workforce and in political entities and work to bridge divides.
Meteorology Blogs
Torrential rainfall Tuesday through Thursday morning (September 16-18) in the Languedoc Region of southern France has resulted in flooding that has killed at least four people with two others still missing. The rainfall rates during the storm were phenomenal.
Looks like that wind I warned people about in my Fantasy Fishing post earlier this week came a day early, postponing things for a day. So what impact will that have on the event, and what of the days to come?
INVEST 95L in the far eastern Atlantic is only significant system in the Tropical Atlantic at this time. More flooding likely in NM & TX as remnants of ODILE continue to impact the SW US.
I often see inaccurate weather information and myths propagating through my Facebook Newsfeed. In the spirit of the "Hail No" segment of Weather Geeks, the show that I host each Sunday at Noon on the ...
This two-day workshop will provide a forum to review and establish procedures for accessibility challenges during relief and evacuation efforts.
Seasonable weather will continue and finish off the climatological summer.
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Monday, June 09, 2008
Weight Loss Update and a check in
Dessert was a green smoothie, pina colada flavored. Just coconut extract, baby spinach, frozen pineapple, frozen banana, stevia and flax meal.
Now, onto weight loss.. I weighed in June 1st and I had lost 4 lbs last month.. not too bad, especially considering I lost 12 the month before. I am hoping to really step it up this month because I'm adding more exercise to my life.
I've been sporadically checking in with all of you, but I am pretty behind.
I ordered my dehydrator! I got the apartment sized 4 tray. I am so lucky I work in a restaurant that is also in a healthfood store. I'll be able to buy large bulk organic produce for cost. I'm really excited about my raw challenge!
22 comments:
You love your new apartment? Yay! I'm so happy for you, Melody. :)ReplyDelete
Welcome back!! So glad that you're loving your new apartment and made progress with your weight loss efforts - fabulous!!ReplyDelete
Mmm, that green smoothie looks so refreshing - yum!
I have one of those huge Excalibur dehydrators - it's great!! Takes up a lot of space, but great, haha :0)
Congratulations on the new place! I've been on a mostly raw week just by default, I think--and it IS too hot to cook! If you're into raw foods you'll love your dehydrator. (I recently sold mine as I just wasn't using it enough and, as VeggieGirl said, it took up a lot of space!).ReplyDelete
- Anonymous9:34 PM
I'm glad that you are enjoying your new apt.ReplyDelete
As for the beet dish, I really and sincerely think it probably tasted good, but when I was a kid, my mother used to make us eat those canned purple beets and I couldn't stand them. In fact, I haven't eaten a beet in probably 30 or more years. :))
Traci Lynn
Welcome back Melody! Congrats on the new apartment, and being so close to your kids.ReplyDelete
Your dinner looks so good! That cashew sauce over the beet shreds looks divine.
Enjoy your new dehydrator and fresh produce.
That raw dish looks incredible! And a green piña colada smoothie for dessert? Sounds perrrfect.ReplyDelete
Your dinner looks beautiful! And congrats on both the weight loss (yippie) and the dehydrator- jealous!ReplyDelete
Congrats on your move--and your weight loss. They say slow n steady is the way to go!ReplyDelete
Your raw food looks raw-some--especially in the middle of this heat wave.
let's see a pictuuuuuure! :)ReplyDelete
loved your cashew sauce. sounds delish..anything with braggs is phenomenal to me.
Congratulations on the weight-loss, and it's great to hear that you're settling in to your new place, since moving is STRESSFUL!ReplyDelete
Your smoothie looks like so much fun! I love the bright green hue!
Congrats on both your new apartment and the weight loss. You're doing great!ReplyDelete
So glad you're liking the new place!!ReplyDelete
And what a refreshing dinner.. I can't wait for your raw challenge either, just so I can see all the food!
Weight loss truths keeps you updated with latest information on weight loss tips, exercises, books and diets apart from enhancing your acumen with in-depth knowledge of traditional weight loss stuff and issues.For more information visit http://www.weight-loss-truths.comReplyDelete


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Evergreen shrubs give depth to your garden even in Winter! Because they keep their leaves, they form 'blocks'. Your garden then appears larger because your field of vision is broken up by these blocks of greenery! (Conifer or Box can also be used to this end). Many of our evergreen shrubs give beautiful flowers too: Your green 'blocks' in the garden switch from colour to colour meaning it is never boring with these evergreen shrubs. Evergreen shrubs are a jewel in your garden the whole year round! Choose the shrubs for your garden, below!
£ 13.85
£ 16.99
£ 17.50
£ 8.95
£ 18.95
£ 19.95
£ 10.95


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Long A-Line Wool Skirt - Women's Sizes: This simply beautiful riding skirt is made in a soft wool blend and has a flattering, A-line silhouette that falls into a subtle swing.
Read what customers are saying about this product:
Rating: 4.67 out of 3 votes cast
Nice Material
I ordered the black and red plaid and I loved the material and the color. As other reviewers have mentioned, it does run big. I ordered the petite size 2 and had to have it hemmed. I wear it to work with a black sweater and black suede boots. It looks very professional so I didn't mind having to pay to have it hemmed.
Blackwood, NJ
Great purchase
I ordered the plaid in 10P and it fits great. I'm an apple shape, no waist, but this A-line skirt is flattering. Nice quality material and well made. It should be noted that if I followed the Chadwick size chart I should have ordered a 16 or 18 because my waist is 36". That would have been HUGE. 10P fits perfect, not tight. (The V-neck pullover, 67756, in Heather Smoke is a nice lightweight, washable sweater and a good match for the plaid wool skirt.)
Crofton, MD
Runs large, and longer than pic
I ordered this in my usual size but had to return it because it was just too big in the waist, and also too long. But I really like the fabric and colors, so I reordered it in the next smaller size, in petite.
Madison WI
Click here to read all of this product's reviews


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You will see a watermark in the bottom right corner of all our images, however, that will not appear on your product when you order it.
Pelons are extremely rare "practice pieces" for the early t-shirt designs. Before production was initiated, the image or design was tested on cotton cloth or burlap to determine the color and line accuracy of the piece. The earlier examples, those dating from the '70s, are generally the only pelons run on burlap. Few of these "tests" were preserved once the design was deemed acceptable and the shirt went into production.


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Habitat for Humanity is a non-profit that helps thousands of valley families get into homes they otherwise couldn't afford.
Now the organization is taking things one step further and helping those new homeowners save money.
The work started bright and early Saturday morning.
A group of volunteers and employees from Harmon Solar installed panels on their own time.
Harmon Solar is teaming up with Habitat for Humanity to make the homes the non-profit builds more energy efficient.
Owner Dan King says this project has been a group effort. Suppliers, for example, donated items.
"We felt that Habitat is a great organization offering the people that they serve a hand up, not a hand out and we like to be affiliated with an organization like that," said Dan Kind.
One home in particular received 12 panels, a system that could potentially save the homeowner up to $600 a year.
"They've been amazing. It's defiantly been a lot of savings and it's allowed me to be able to use money that I would have spent on so much electric bills like other things like say the mortgage, groceries," said Fatima Martinez, a Habitat for Humanity home owner.
Martinez lives two doors down from the house being constructed. Martinez moved into her habitat home about a year ago.
She has received bills as low as $40 a month and is hopeful her neighbor will have the same results.
"It's amazing, it's great to be able to see that another family is going to be able to benefit from something--that's just going to help her out, so much for her and her kids," said Martinez.
"I think that it sends a message just to everybody, everybody is more conscious being energy conscious," said King.
This is the company's fourth home with Habitat and by no means the last.
Harmon Solar hopes to install panels in several more homes in the year to come, saving even more people more money.
The house worked on Saturday will go to a single mom of four. She happened to be moving Saturday and wasn't able to share her excitement about the new home.
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The Under 30 night is a great opportunity to connect with other young people in the New York City area who are interested in meditation. The evening features meditation practice, with instruction provided for anyone coming for the first time or who would like a review. Meditation is followed by a discussion exploring an aspect of bringing the practice of meditation, or the Shambhala Buddhist teachings, into everyday life. The evening concludes with refreshments and mindful socializing.
Shambhala Online Teleclasses
Intro Meditation Programs
Find a Meditation Centre
Quick View of Programs by Center


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Ranges in price (i.e. $98-$550) means there are multiple printings and/or sizes available. Click on an item to view a list of printings and prices.
The Vault's retro and vintage pin collection ranges from round, metal, campaign-style mementos of specific concerts, events and political statements to square tokens of promotional album imagery. Many bear the likeness of a performer, album cover or the salient graphic from a poster that advertised an event. Vintage pins from as early as 1966 tout the coolest shows and hottest rockers, while our retro designs bring the greatest icons of image and sound to the lapel and knapsack.
Bruce Hornsby,
Phil Lesh,
Bob Weir,
Vince Welnick


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New Zealand Embassy Madrid, Spain
Marriage in New Zealand
The Marriages section of the Department of Internal Affairs website will tell you what you need to know about legal requirements when getting married in New Zealand.
Of interest
United Nations Handbook
The UN Handbook is a comprehensive guide to the UN system and how it works. Read more
Elections for the United Nations Security Council
New Zealand is a candidate for election to the UNSC for the two-year term 2015-16. Read more
Registering your overseas travel made easier
New Zealanders travelling or living overseas, registering your travel online now made easier. Read more
The Christchurch Earthquake Appeal
News about how the donations are contributing to the rebuild, ways to donate and more.


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Software Map
Tag cloud | Project Tree | Project List
Project tree
Now limiting view to projects in the following categories:
Programming Language :: C++ [Remove This Filter]
Intended Audience :: Database Administrators [Remove This Filter]
Topic :: PostgreSQL Enhancements :: Data Types [Remove This Filter]
Development Status > 4 - Beta
Browse By:
1 project in result set.
|0. SparseGraph: a fast graph data structure - SparseGraph implements an efficient data type and related functions for storing and querying large, sparse directed or undirected graphs. Its focus is on making graph queries efficient, so it is not optimized for the case of frequently-changing graphs.
|Activity Percentile: 0.00
Activity Ranking: 0.00
Registered: 2007-03-16 03:24


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Customer Testimonial
Baby & Kids department
Celebrate your little ones with personalized Christmas ornaments for babies and kids!
Personalized Baby OrnamentsWelcoming a new baby this Christmas? There are plenty of unique Christmas gifts that you can get for infants and babies. Personalization Mall offers you the opportunity to customize baby ornaments and make them your own. Choose any one of our amazing items and personalize it to make it extra special. Spread the joy of Christmas with beautiful gifts from Personalization Mall.


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The CEO of Metra has resigned and is set to get a more than $442,000 buyout.
The Chicago Sun-Times reports Alex Clifford stepped down Friday during a board meeting. A separation agreement from the suburban Chicago commuter rail says he's leaving the post immediately.
Metra Chairman Brad O'Halloran said Clifford was departing because of a "difference in opinion" on the direction of the rail network.
Clifford joined Metra from a California transit agency three years ago. His contract was set to expire this coming February.
He replaced long-time executive director Phil Pagano, who committed suicide.
Copyright 2013 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
Follow @fox32news
KTTV FOX 111999 S. Bundy Dr.Los Angeles CA 90025Main: (310) 584-2000News Tips? (310) 584-2025


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SIBLEY — The Lakeside Lady Warriors will host their 4th Annual Alumni Game on Saturday, May 14 at Lakeside High School.
The games get started at 5 p.m. with the seventh grade boys vs. the eighth grade boys. At 6:15 p.m., the Woman's Alumni Game tips off, followed by the Men's Alumni Game at approximately 7:15 p.m.
There will be a $3 entry fee for these games.


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The Top 10 In Action Sports
01Rachel Atherton Leads The Biggest All-Female MTB Event Ever Held… And She's Still Looking Higher
02'I'm A Pro Surfer And A... Golfer?' The Secret Lives Of Surfers When They're Not Riding Waves
03World Renowned Freeskiers Confirmed Dead After Tragic Avalanche
04So, What's New With The GoPro HERO4? We Tried It Out With Danny MacAskill And Jason Paul...
05Whips, Flips And Broken Curses: The Red Bull Rampage Epic Blew The Doors Off Again
06GoPro Just Launched The New HERO4 Range. We Got A Chance To Have A First Look...
07Win Tickets To The European Outdoor Film Tour 2014
08What Happens When You Mix Neon Lights With Night Skiing? The Result Is Pretty Incredible...
0936 Hikers Feared Dead After Japan's Second Biggest Volcano Erupts
10One Day You May Be Forced To Quit Surfing. Here's How To Spot The Signs Early
Squaw Valley Update 3/4/09
A Snowboarding video by Mpora - 675 views
Over six feet of snow has fallen on Squaw Valley in recent days and conditions are epic.
squaw valley usa ski snowboard events events restaurants new snow fresh deep powder squallywood
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The Video Game Release List of 2/3 - 2/9
This week has a little bit of something for everyone, especially for those that own a PC, PlayStation 2, PlayStation 3, Xbox 360, Wii, Nintendo DS, or PSP. Highlights, as pictured below, include Devil May Cry 4 (preview), Twisted Metal: Head-On: Extra Twisted Edition (details), and Sins of a Solar Empire (interview). For more on Devil May Cry 4, be sure to scope out our full review.
Barring any unforeseen delays, most stores should have this week's games by Wednesday, February 6.
In case you just can't wait until then to get your hands on the equestrian lifestyle simulator glory that is My Horse & Me (PC, Wii, DS), we have a demo of the PC version up on FileShack.
Note: Though some retailers are already selling the PlayStation 3 and Xbox 360 editions of Propaganda Games' Turok (preview), its official release date is Tuesday, February 5.
PC 20 Questions, Dance! Online, First Battalion Gold Edition, Forgotten Riddles: The Mayan Princess, Medieval II Total War Gold Edition, Merv Griffin's Crosswords, My Horse & Me, Sins of a Solar Empire, Spaceforce Captains, The Spiderwick Chronicles
PlayStation 2 Karaoke Revolution Presents American Idol Encore, Karaoke Revolution Presents American Idol Encore Microphone Bundle, Nobunaga's Ambition: Rise to Power, The Spiderwick Chronicles, Twisted Metal: Head-On: Extra Twisted Edition
PlayStation 3 Devil May Cry 4, Devil May Cry 4 Collector's Edition, Turok
Xbox 360 Culdcept Saga, Devil May Cry 4, Devil May Cry 4 Collector's Edition, Karaoke Revolution Presents American Idol Encore Microphone Bundle, The Spiderwick Chronicles, Turok
Wii Karaoke Revolution Presents American Idol Encore Microphone Bundle, My Horse & Me, The Spiderwick Chronicles
DS Assassin's Creed: Altair's Chronicles, My Horse & Me, Pets & Claws Pet Resort, Puppy Palace, Real Soccer 2008 (GameStop Exclusive), The Spiderwick Chronicles, Zoo Tycoon 2 DS
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Dr. Norman Geisler,
PhD, is a prolific author, veteran professor, speaker, lecturer,
traveler, philosopher, apologist, evangelist, and theologian. To
those who ask, "Who is Norm Geisler?" some have suggested,
"Well, imagine
a cross between Thomas Aquinas and Billy Graham and you're not
too far off."
Norm has authored/coauthored over 80 books and hundreds of articles. He has taught theology, philosophy, and apologetics on the college or graduate level for over 50 years. He has served as a professor at some of the finest Seminaries in the United States, including Trinity Evangelical Seminary, Dallas Seminary, and Southern Evangelical Seminary. He now lends his talents to Veritas Evangelical Seminary in Murrieta, California, as the Distinguished Professor of Apologetics. (Read more)
|Available Now!
The Jesus Quest:
The Danger from Within
(Click the picture below for more details)
Former President of the Evangelical Theological Society speaks out on its founding Principle
Review of Five Views of Biblical Inerrancy
New Articles by Dr. Geisler:
Who Muddied Which Waters?
A Response to Craig Blomberg's Can We Still Believe in the Bible?
Is Genre Criticism of the Gospels Contrary to the Inerrancy of Scripture?
A Response to Ken Ham and Answers In Genesis On Does Inerrancy Require Believe in a Young Earth?
A Critical Review of Donald Hagner's "Ten Guidelines for Evangelical Scholarship." by Dr. F. David Farnell and Dr. Norman Geisler
The ETS Vote on Robert Gundry at their Annual Meeting in December 1983
Does believing in Inerrancy require one to believe in Young Earth Creationism?
Does Thomism Lead to Catholicism?
Dr. Geisler's
When Skeptics Ask has been revised, updated, and
The wait is over!
The Popular Handbook of Archaeology and the Bible
by Dr. Holden and Dr. Geisler is available!
Interested in training
on evangelism and pre-evangelism?
Please check out Dr. David Geisler's
CPE training here!
Explaining Biblical Inerrancy
What does the Chicago Statement on Biblical Inerrancy *really* mean? We're excited to announce that the newest e-book at Bastion Books, titled Explaining Biblical Inerrancy, is a combination of two classic, priceless, hard-to-find, strategic, profound, must-have resources! In it we've got forty pages by Dr. R.C. Sproul explaining the Chicago Statement on Biblical Inerrancy, twenty-two pages by Dr. Norman Geisler explaining the articles of the Chicago Statement on Biblical Hermeneutics, and ten pages by Dr. Geisler outlining the challenges to and misunderstandings of the ICBI standards of inerrancy that have been common in the last thirty years. Please spread the word and help us get this e-book onto the computers and e-readers of every seminary professor, Bible teacher, and Bible student.
Check out http://BastionBooks.com
to get Dr. Geisler's latest eBooks!
The Big Book of Christian Apologetics is available!
(Details here)


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No. 6 Gonzaga (21-2, 8-0) hosts Pepperine (10-12, 2-7) Thursday at 8:00 p.m. in the McCarthey Athletic Center. The game will be televised on Root Sports.
The Stats - When these teams met in their WCC opener on January 3rd Pepperdine's inability to knock down three-pointers and take care of the ball ultimately cost them. The Waves held an eight-point lead in the first half, but Gonzaga rallied for a four-point advantage at the break, before leaving Pepperdine in their wake to the tune of a 78-62 victory. Mark Few's club held Pepperdine to 2-for-12 shooting from deep, which even for a team that averages just 4.8 made threes in WCC play is a poor outing. They also have a habit of committing turnovers, averaging 2.89 more than their opponents in 11 league contests. Against Gonzaga they coughed it up 14 times (compared to 12 assists), which turned into 21 points for GU. Also, Pepperdine is 0-10 when allowing 67 points or more. That's proven to be a very reachable number for the Zags.
The Stars - Lorne Jackson still paces the Waves offensively, as he did with 16 points off the bench on January 3rd. In that game he also turned it over on four occasions. The senior guard has claimed at least a share of top-scoring honors for Pepperdine in 10 of their 22 games, and is now averaging 14.3 points per game. Jordan Baker is second at 11.7, including a 15-point outing against the Zags. In that game Elias Harris and Kelly Olynyk tallied 34 of the Zags 78 points. It will be interesting to see how teams defend GU the second time around. If their focus is on limiting the interior guys, Gary Bell Jr. could continue his hot streak. He used five threes to hang 15 on LMU, before posting an efficient 13 points at USD. It's pick your poison with the Zags. Last week no one put up any gaudy numbers. Instead it was their variety that caused fits. Any number of players could set the tone, but it wouldn't be a shock to see Harris and Bell lead the charge again.
The Storylines - Pepperdine's last win in Spokane came back in 1998. Since then they've suffered 14 straight losses in road games against the Bulldogs. In total, Gonzaga has bested the Waves on 23 consecutive occasions, with wins in 38 of the last 43. The Waves did give GU some fits in the first half of their first meeting. It will be interesting to see which team that experience favors. Will Pepperdine be better prepared to hang with GU down the stretch? Or will the Zags be clued in on how to take charge against the Waves, and do so right out of the gates?


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The leather-look impala is a luxurious vinyl for modern and classical living. It's high-quality faux leather texture with a rich mix of natural shades and highly-detailed stitch squares. The authentic acanthus leaves enhance an opulent classical surrounding, while adding an ambiance of sophisticated elegance. Impala is manufactured on very easy-hang, non-woven base. It's seamless, shadeless and scratchfree; qualities for which Grandeco is renowned.
Please note - To ensure consistent colours, it is important that every roll of wallpaper has the same batch number. At diy.com we do this for you for all home delivered orders, however be sure to double check when reserve & collecting your order in store.
Request a free sample
*Free delivery over £50 refers to home delivery orders placed on diy.com only. Charges refer to the value of goods being delivered and excludes delivery from stores or services. Excludes bulk delivery.
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|Calangute Beach,
|750 meters
|February 2013
|Includes breakfast
|March 2013
|Includes Breakfast
|April 2013
|Includes Breakfast
Pool Side Holiday Rentals in Goa(Near Beach)
North, India Vacation Rentals
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75 Per Night
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This modern 4 air conditioned bedroom/4 full bath accommodation offers panoramic views of the ocean and valley. If you are looking for a restful vacation in tranquil surroundings with gorgeous views this is the place for you....
Starting at $150 Per Night
Garden View Apartment in beach side resort
North, India Vacation Rentals
Our apartments are located in a beautifully landscaped and upscale seaside resort on the world famous Candolim beach, which has been rated by visitors as the best beach in Goa....
Starting at $75 Per Night
fully furnished apartment in North Goa, Calangute
North, India Vacation Rentals
fully furnished apartment with 1 bedroom with attached bathroom, 1 living room with sofa cum bed and open kitchen. both rooms have AC's. walking distance from main markets, pubs, entertainment and beach...
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Fully furnished 1 bedroom apartment with attached toilet and seperate living cum dining cum kitchen. new residential complex with swimming pool near main market and beach. 2 ac's, refrigerator, microwave, washing machine, tv, 24 hr hot cold water etc...
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Goa Casitas Serviced Vacation Villa and Apartment
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Goa Casitas offers exquisite villas and serviced apartments situated in the prime locations offering peace and tranquility of the goan culture and ambiance and at the same time in the midst of the vibrant city....
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Idyllic Beaches In South Goa
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We have some lovely properties on complex in south goa 5 mins from beach air coditioned sky tv balconies etc , very quiet deserted lovely beaches ...
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I'm searching for clues on a mustard and butter-based steak sauce I used to love when I lived in Paris. It was served at a restaurant in the 8th, as I recall, and was the only item on their menu. Steak Frites with this sauce. It certainly consisted of Dijon Mustard and butter and possibly very finely minced shallots...maybe Brandy but it certainly didn't taste of it...but everything I've tried to make either isn't mustardy enough or the wrong consistency.
Any thoughts?


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Switching Adjuvant Breast Cancer Therapy from Tamoxifen to Exemestane Proves Beneficial
A new study has found a strong benefit of an aromatase inhibitor (AI) as adjuvant therapy in postmenopausal breast cancer patients. Published last week in the New England Journal of Medicine, the study found that switching adjuvant therapy after two to three years from tamoxifen to the AI exemestane significantly improved disease-free survival at approximately two and a half years' follow-up. Conducted under the auspices of the Intergroup Exemestane Study (IES), the results were made available at the recommendation of the study's data and safety monitoring board following the second interim data analysis review.
More than 4,700 patients - all of whom had primary, estrogen-receptor-positive breast cancer - were enrolled in the double-blind, randomized trial, with slightly less than half assigned to undergo the midstream switch in adjuvant therapy from tamoxifen to exemestane. After a median follow-up of nearly 31 months, there were 266 first events (defined as breast cancer recurrence, contralateral breast cancer, or death) in the tamoxifen group and 183 in the exemestane group, leading to a 32 percent relative reduction in the risk of an event and an overall benefit of disease-free survival of 4.7 percent. Because these are early release results, the authors explained, it is too soon to expect a statistically significant difference in overall survival. Patients in the exemestane group also had a reduced risk of contralateral breast cancer, endometrial cancer, and other primary cancers. Read more
Annual Cancer Center Directors' Retreat
On Monday, March 8, National Cancer Institute (NCI) convened a cancer centers directors' retreat in which 59 of 61 NCI-designated cancer centers participated. The purpose of the retreat was to discuss future opportunities and challenges and the critically important role that the cancer centers play in the National Cancer Program. New technology initiatives and ongoing implementation of the report of the NCAB P30/P50 Ad Hoc Working Group (chaired by Drs. Joe Simone and Art Nienhuis) were central themes. The retreat included the cancer center directors in strategic discussions to facilitate the discovery, development, delivery continuum.
In the late 1960s, 12 cancer centers were NCI-funded. With the enactment of the National Cancer Act in 1971, the Cancer Centers Program formally established and funded 15 additional cancer centers. "The National Cancer Institute should closely study the use of cancer research centers," the legislation stated, "for it is here that many impressive research findings are being and will be uncovered. It is also here that the effectiveness of these findings can be proved." In fact, our cancer centers have become extraordinary gravitational forces attracting intellectual capital, financial resources, and programmatic opportunities. Read more
Switching Adjuvant Breast Cancer Therapy from Tamoxifen to Exemestane Proves Beneficial
A new study has found a strong benefit of an aromatase inhibitor (AI) as adjuvant therapy in postmenopausal breast cancer patients. Published last week in the New England Journal of Medicine, the study found that switching adjuvant therapy after two to three years from tamoxifen to the AI exemestane significantly improved disease-free survival at approximately two and a half years' follow-up. Conducted under the auspices of the Intergroup Exemestane Study (IES), the results were made available at the recommendation of the study's data and safety monitoring board following the second interim data analysis review.
More than 4,700 patients - all of whom had primary, estrogen-receptor-positive breast cancer - were enrolled in the double-blind, randomized trial, with slightly less than half assigned to undergo the midstream switch in adjuvant therapy from tamoxifen to exemestane. After a median follow-up of nearly 31 months, there were 266 first events (defined as breast cancer recurrence, contralateral breast cancer, or death) in the tamoxifen group and 183 in the exemestane group, leading to a 32 percent relative reduction in the risk of an event and an overall benefit of disease-free survival of 4.7 percent. Because these are early release results, the authors explained, it is too soon to expect a statistically significant difference in overall survival. Patients in the exemestane group also had a reduced risk of contralateral breast cancer, endometrial cancer, and other primary cancers.
"These findings are consistent with results from two other large, adjuvant trials testing AIs, some smaller adjuvant trials, and trials comparing AIs to tamoxifen for metastatic disease," said Dr. Jeff Abrams, associate chief of medicine in the NCI Cancer Therapy Evaluation Program. The extent and early appearance of the benefit "is impressive," he added.
The two large trials Dr. Abrams referred to had different designs than the IES. In the ATAC trial, published in The Lancet in June 2002, there was a statistically significant improvement in disease-free survival for postmenopausal women who received adjuvant monotherapy with the AI anastrozole compared to tamoxifen. The Food and Drug Administration has since approved anastrozole for monotherapy in this patient population. In a study published last November in the New England Journal of Medicine, use of the AI letrozole in postmenopausal women who successfully underwent five years of monotherapy with tamoxifen yielded a statistically significant reduction in breast-cancer-related events compared to placebo.
As a result of these trials, the most effective role of AIs and tamoxifen in adjuvant therapy in postmenopausal women has been hotly debated. An American Society of Clinical Oncology working group has recommended five years of monotherapy with tamoxifen as the preferred adjuvant therapy. But the results of the IES study, the trial's authors argued, challenge "the concept of five years of monotherapy with endocrine agents after the surgical treatment of primary breast cancer."
Data are still lacking for AIs on overall survival, however, and there are unanswered questions about long-term toxicity, Dr. Abrams explained, including whether long-term estrogen deprivation (AIs work by decreasing the blood levels of estrogen) causes other symptoms.
Despite these lingering questions, AIs definitely have an important role in the treatment of breast cancer, he added. "AIs are a good choice for women with hormone-sensitive breast cancer, either as first-line treatment or as a switch-over after some period of time," he said. "Whether switching or going with an AI from the start is best will have to be decided by future research." A number of such studies are under way, including a European trial testing both letrozole and tamoxifen in monotherapy and midstream-switching regimens.
"Future trial results should help us resolve the question of whether AIs should totally replace tamoxifen or whether they should both be used in sequence," Dr. Abrams said. "And with more time, the ATAC trial will provide information on AI long-term side effects."
Annual Cancer Center Directors' Retreat
In the late 1960s, 12 cancer centers were NCI-funded. With the enactment of the National Cancer Act in 1971, the Cancer Centers Program formally established and funded 15 additional cancer centers. "The National Cancer Institute should closely study the use of cancer research centers," the legislation stated, "for it is here that many impressive research findings are being and will be uncovered. It is also here that the effectiveness of these findings can be proved." In fact, our cancer centers have become extraordinary gravitational forces attracting intellectual capital, financial resources, and programmatic opportunities.
A significant portion of NCI's funding portfolio is vested in these cancer centers. To their great credit, the centers have leveraged this investment with contributions from academic institutions and private philanthropy to build programs in cancer research, nanotechnology, prevention, care, and education that receive world-wide acclaim. How are we then going to optimally utilize this enormous resource? By greater integration among cancer centers and greater coordination with NCI and health delivery systems. To assist in this integration and coordination among the cancer centers, a significant outcome of the retreat was enthusiastic agreement to immediately begin to adopt the cancer Biomedical Informatics Grid (caBIG) for clinical research. caBIG can immediately offer the cancer centers Web-based clinical trials protocol sharing, clinical trials data capture tools, and participant registry based on common vocabularies and data elements. Additionally, retreat participants discussed how to manage planned technology development to maximize capabilities across the cancer community. NCI continues to foster more integration among the intramural and extramural clinical research enterprises and state and regional cancer programs. We need to encourage geographic associations of groups that will increase their impact by affiliation - particularly in underserved areas.
Guidelines for the cancer centers are undergoing revision to simplify and provide for a more streamlined review process. Other priority areas:
The chance to share ideas among NCI leadership and the cancer center directors provided a valuable opportunity to synergize and integrate this important resource of the National Cancer Program; I plan to repeat it annually. I also reported on the retreat at the joint Board of Scientific Advisors/Board of Scientific Counselors meeting yesterday. For additional information on the cancer centers and a list of the directors, see http://cancercenters.cancer.gov/
Dr. Andrew C. von Eschenbach
Symposium Celebrates 30 Years of U.S.-Japan Cooperation on Cancer Research
The two keynote speakers at the March 1-2 Molecular Cancer Therapeutics Symposium, sponsored by NCI and the Japan Society for the Promotion of Science, had different topics but similar messages: Cancer researchers must reconsider old assumptions. The symposium was held to celebrate 30 years of cooperation between the United States and Japan in cancer research and included presentations from Japanese and U.S. researchers on a wide range of research related to molecular therapeutics.
Mounds of genomics data on the 110 identified human cancers will be collected and analyzed in the coming years, said Dr. Robert Weinberg, of the Whitehead Institute and Massachusetts Institute of Technology, in his address. "This provokes the question of whether…any fundamental laws [will] be developed that will help us understand all of these various kinds of human cancer," he said. An essential part of developing such laws, he added, is to look more closely at the tumor microenvironment. For example, mounting evidence suggests that stromal cells play an important role in tumor pathogenesis. A number of studies conducted in the United States and Japan have shown how, in mice, stromal fibroblasts interact with cancer cells to significantly accelerate tumor growth and cancer progression. Dr. Weinberg also cited laboratory studies that have pointed to other important elements in the microenvironment, such as specific transcription factors that may help cancer cells acquire attributes that help to promote their proliferation and metastasis.
In terms of future research, such elements, he said, "take the focus away from disrupting autonomous circuits within cancer cells to an additional consideration of how the cancer cells…are recruiting and subverting normal cells [around them] in order to accelerate their own agenda of tumorigenesis."
In her keynote speech, Dr. Julie Buring, of Brigham and Women's Hospital in Boston, discussed some of the controversy surrounding instances where observational studies have appeared to conflict with randomized clinical trials that addressed the same issue. Although such inconsistencies are to be expected, she said, divergent findings can also be a symptom of trials that aren't necessarily attempting to answer the same question.
Observational and randomized trials that looked at the effect of beta-carotene on cancer risk, for example, yielded discrepant findings. The observational studies found a benefit, while randomized trials did not, and in some cases even revealed adverse effects. But the design of the randomized trials, Dr. Buring noted, may very well have been the telling factor. The observational studies, for instance, included people who had a long-term diet high in fruits and vegetables, whereas the randomized trials involved giving high-dose beta-carotene supplements to participants.
The discrepant findings could have meant that the randomized trials were doing what they are supposed to do: confirm or disprove an observational finding. "But maybe [the randomized trial investigators] made the wrong leap," she said. Perhaps the observed benefit in fruits and vegetables came from more than just beta-carotene, she added, and the synergy of the nutrients from the fruits and vegetables was lost.
Looking forward, Dr. Buring said, investigators must thoroughly consider factors like patient characteristics, agent characteristics, and underlying biology up front when designing clinical trials on the basis of observational study results.
Breast Cancer Sister Study Going Nationwide
The National Institute of Environmental Health Sciences (NIEHS) is rolling out a nationwide research effort to uncover possible environmental and genetic causes of breast cancer. The NIEHS "Sister Study," now running in four states - Arizona, Florida, Missouri, and Rhode Island - is recruiting the sisters of women diagnosed with breast cancer to study shared cancer risks. Recruitment throughout the United States will begin later this year, with an eventual goal of 50,000 volunteers.
NIEHS researchers are enrolling women, aged 35 to 74, who have not had breast cancer themselves but have a sister diagnosed with the disease. During the Sister Study - the only long-term study of its kind - participants will be followed for 10 or more years in hopes of finding why sisters are more likely to develop breast cancer. Scientists speculate that this higher risk could be caused by shared genes, a common diet, a common environment in youth, or even common gene-environment interactions.
There will also be increased efforts to enroll minority women as they, too, are known to be at greater risk for developing breast cancer. For example, African American women aged 30-59 have the highest breast cancer death rate. Dr. Dale Sandler, NIEHS Epidemiology Branch chief and principal study investigator, said, "We hope that a long-term study with many racially and ethnically diverse women will yield new results that will benefit future generations."
For more information about the Sister Study or to enroll, go to http://www.sisterstudy.org or call toll free 1-877-474-7837.
Freezing Ovarian Tissue for Later Transplantation May Restore Fertility
Researchers in New York reported an intriguing finding last week that may offer hope for women who become infertile as a result of cancer treatments like chemotherapy or radiotherapy. In a brief paper published in the March 13 issue of The Lancet, a team from the NewYork-Presbyterian Hospital/Weill Cornell Medical Center reported on a case in which they cryopreserved ovarian tissue from a 30-year-old woman with breast cancer before she underwent chemotherapy. Six years later, after the woman had undergone successful treatment for cancer, the tissue was thawed and transplanted beneath the skin of her abdomen. The patient's ovarian function returned after three months.
Over the next eight months, the team was able to retrieve eight viable oocytes for use in in-vitro fertilization with her husband's sperm. From this, one four-cell embryo was produced and transferred to the patient's uterus. She did not, however, become pregnant. In a news release, the lead investigator, Dr. Kutluk Oktay, said the research "represents a potentially significant reproductive advancement in two respects: first, women can preserve their fertility by freezing their ovarian tissue, and second, pregnancy may be possible even after the tissue remains frozen for a long time."
In an editorial that accompanied the study, Prof. Johan Smitz from the Centre for Reproductive Medicine, University Hospital of the Vrije Universiteit Brussels, Belgium, offered words of caution. Because of many unknowns related to cryopreservation and screening tissue for transplant, he wrote, this option "should still be presented as experimental to patients."
Earlier this month, cancer biologists, engineers, chemists, and clinicians convened at two cancer nanotechology symposia to develop a vision for integrating nanotechnology into cancer research. Several leading investigators from the public and private sectors participated in these meetings, which were held at the Salk Institute for Biological Studies in La Jolla, Calif., and the Fred Hutchinson Cancer Research Center (FHCRC) in Seattle, Wash. In addition to promoting new types of multidisciplinary teamwork, these symposia allowed NCI to obtain input on its Cancer Nanotechnology Plan (CNP), a strategic approach for developing new nanotechnology tools to accelerate clinical and research advances. Complete agendas for both meetings are available from NCI's Office of Technology and Industrial Relations Web site.
At these symposia, Dr. Mauro Ferrari, professor of biomedical engineering and internal medicine at Ohio State University, presented seven key strategic challenges to be addressed in the CNP: fundamental science, prevention and control, early detection, imaging diagnostics, multifunctional therapeutics, nanosystems for quality of life, and training. He also described NCI's plan for a laboratory focusing on biological characterization of nanoparticles. This laboratory will catalyze a confluence of nanotechnology and cancer research by developing protocols for validation, comparison, and objective evaluation of nanodevices for cancer and by creating a public database for research dissemination.
Several presentations at both meetings elaborated on CNP's seven strategic challenges. At the La Jolla symposium, the keynote speakers highlighted the need for multifunctional nanoparticles. Dr. Leroy Hood, president of the Institute for Systems Biology, spoke about how a diverse panel of interventions is required to address the multiple malfunctions that lead to cancer. The second keynote speaker, Dr. James R. Baker, Jr., director of the Center for Biologic Nanotechnology at the University of Michigan Medical School, described how a single type of nanoparticle can be engineered to have diverse capabilities for detecting cancer, delivering therapies, and monitoring the efficacy of treatments.
In Seattle, the keynote talks focused on the need to develop nanodevices to enable cancer imaging. Dr. Douglas Hanahan, professor in the Department of Biochemistry and Biophysics at the University of California, San Francisco, described the use of imaging techniques in mouse models to identify molecular targets and to monitor the ability of drugs to influence these targets. Dr. Samuel Wickline, professor of medicine, physics, and biomedical engineering at Washington University in St. Louis, discussed the functionality of multivalent lipid-based nanoparticles to target angiogenesis for imaging and therapy.
At the conclusion of the Seattle symposium, Dr. Ferrari and FHCRC Director Dr. Lee Hartwell led a roundtable discussion that identified several scientific priorities that should be considered within the framework of the CNP, including monitoring modifications of biological response during therapy to help shorten the pathway to regulatory approval, developing new models for studying cancer, detecting cancer earlier in its natural history through imaging or serum-based methods, providing new approaches for contrasting tumor tissue to normal tissue at important stages of tumor development, and accelerating the detection of therapeutic efficacy.
Building on the success of the La Jolla and Seattle meetings, NCI plans to convene additional cancer nanotechnology symposia over the next several months. In addition to promoting new cross-disciplinary dialogue, these symposia will help engage the extramural scientific community in NCI's planning efforts to ultimately bring a new nanotechnology toolkit to the nation's cancer researchers.
Dr. Mauro Ferrari, professor of biomedical engineering and internal medicine, Ohio State University, is a leader in the field of biomedical nanotechnology. Dr. Ferrari is currently working as an expert consultant at NCI's Office of Technology and Industrial Relations to help develop a strategy for incorporating nanotechnology tools into cancer research.
How would you describe the relevance of nanotechnology to cancer researchers?
How did you become interested in applying nanotechnology specifically to cancer?
What is the most promising near-term application of nanotechnology to cancer?
Ovarian Cancer Prevention and Early Detection Study
Name of the Trial
Principal Investigator
Why Is This Trial Important?
Neither the impact of preventive surgery on quality of life, nor the consequences of premature menopause, have been carefully studied in women at high risk. At present, there is no proven screening strategy shown to decrease mortality due to ovarian cancer.
This national trial, conducted with the Gynecologic Oncology Group and the Cancer Genetics Network, will more precisely quantify the extent of cancer risk reduction after preventive surgery, assess both quality of life and incidence of non-cancer diseases related to premature menopause, and evaluate a novel approach to ovarian cancer screening based on quantitative assessment of changes in CA-125 over time.
"About 30 percent of women with ovarian cancer survive longer than five years," said Dr. Greene. "But, if diagnosed and treated before the cancer spreads beyond the ovaries, 90-95 percent of patients live longer than five years. Developing effective prevention and early detection methods is crucial in fighting this disease, particularly for women who are at much greater risk."
Who Can Join This Trial?
Where Is This Trial Taking Place?
Who to Contact
An archive of "Featured Clinical Trial" columns is available at http://cancer.gov/clinicaltrials/ft-all-featured-trials.
NCI Meetings on Real-Time Health Research Using e-Technology
The Health Promotion Research Branch of NCI has sponsored two meetings with nationally recognized researchers to discuss the topic of real-time health research using e-technology. The first conference, entitled "The Science of Real-Time Data Capture: Self-Reports in Health Research," was held Sept. 5-7, 2003, and brought together researchers from a variety of disciplines to discuss the theory, methodology, and application of real-time research in self-reported health. A summary, meeting presentations, and speaker biographies are highlighted at http://dccps.cancer.gov/hprb/real-time/index.html. A follow-up working group meeting, entitled "Capturing Physical Activity and Diet in Real-Time," was held Jan. 22 to focus specifically on real-time research with these two key health behaviors, which are central to cancer prevention and control.
Information garnered from these meetings has been used in the development of the NIH Roadmap initiatives "Meetings and Networks for Methodological Development in Interdisciplinary Research" and "Dynamic Assessment of Patient-Reported Chronic Disease Outcomes." In addition, ideas and recommendations from the meetings are informing the development of the NCI energy balance initiatives. For further information about these meeting and activities, visit the above Web sites or contact Dr. Audie Atienza at (301) 402-8246 or firstname.lastname@example.com.
NCI Sponsors Breast Cancer and the Environment Research Centers Meeting
The centers and principal investigators are the Fox Chase Cancer Center, Philadelphia, Dr. Jose Russo; Michigan State University, East Lansing, Dr. Sandra Z. Haslam; the University of Cincinnati, Dr. Sue C. Heffelfinger; and the University of California, San Francisco ("Bay Area Center"), Dr. Robert A. Hiatt.
Functioning as a consortium of basic scientists, epidemiologists, research translational units, and community advocates within and across centers, BCERC will investigate mammary gland development in animals and young girls to determine vulnerability to environmental agents that may influence breast cancer development in adulthood. NCI program support, to parallel the multidisciplinary breadth of BCERC, is being provided by DCCPS and the Division of Cancer Biology.
Feigal Leaving NCI
A medical oncologist with a background in AIDS research, Dr. Feigal joined the Cancer Therapy Evaluation Program 12 years ago. She oversaw clinical trials on lung cancer and head and neck cancers and created the NCI AIDS malignancy clinical trials program. She has continued to head the program, which directs the national AIDS and Cancer Specimen Resource and sponsors the premier annual, international meeting in this field.
Dr. Feigal became DCTD deputy director in 1997 and acting director in 2001. Under her leadership, the division has focused on revamping clinical trials and fostering public-private partnerships; enhancing and expanding the cancer imaging program; and using genomic, gene expression, and other data to develop molecularly targeted drugs.
PDQ® Clinical Trials Database Grows
PDQ has been the source of most of the cancer clinical trials in ClinicalTrials.gov since that database's inception. However, ClinicalTrials.gov obtains trial information from other sources, including the pharmaceutical and biotech industries. This exchange of information between NCI and NLM will provide a closely matched set of cancer clinical trials on the cancer.gov and ClinicalTrials.gov Web sites.
This is a list of selected scientific meetings sponsored by NCI and other organizations. For locations and times and a more complete list of scientific meetings, including NCI's weekly seminars and presentations open to the public, see the NCI Calendar of Scientific Meetings at http://calendar.cancer.gov.
NCI Exhibits