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Fracture Reduction -- Open
- Home
- Health Info
- Fracture Reduction -- Open
(Setting a Fracture)
Reasons for Procedure
- So that the bone can heal properly and more quickly
- To decrease pain and prevent later deformity
- To regain use of the bone and limb
Possible Complications
- Nerve damage
- Infection
- Bleeding
- Fat particles from the bone marrow or blood clots from veins that may dislodge and travel to the lungs
- Need for additional surgery if the bone does not heal properly
- Reaction to anesthesia
- Advanced age
- Preexisting medical condition
- An open fracture (broken bone is sticking out of skin)
- Diabetes
- Use of steroid medicine
- Smoking
- Obesity
What to Expect
Prior to Procedure
- Physical exam
- X-ray —to look for the location and type of fracture
- Provide a splint for the broken bone to decrease the risk of additional injury until it can be reduced
Talk to your doctor about your medicines. You may be asked to stop taking some medicines up to one week before the procedure, like:
- Anti-inflammatory drugs (such as, aspirin )
- Blood thinners, like warfarin (Coumadin)
- Clopidogrel (Plavix)
- You may need to take antibiotics, if advised by your doctor.
- If you are at home arrange for a ride to and from the procedure. Also, arrange for help at home.
- Eat a light meal the night before. Do not eat or drink anything after midnight.
- General anesthesia —blocks pain and keeps you asleep through the surgery
- Local anesthesia—numbs the area; given as an injection (You may also be given a sedative.)
Description of the Procedure
|Open Reduction of Tibia
|Copyright © Nucleus Medical Media, Inc.
Immediately After Procedure
How Long Will It Take?
How Much Will It Hurt?
Average Hospital Stay
Post-procedure Care
- Rest your injured arm or leg on pillows. Elevate it above the level of your heart.
- Gently move uninjured joints and toes.
- Keep the cast, splint, and dressing clean and dry.
- Wait until a "walking cast" is dry before walking on it.
- Do not pull out the cast's padding. Do not break off any part of the cast.
- Keep objects, dirt, and powder out of the cast.
- Do not try to scratch under the cast.
- Do not drive until told it is safe.
- Change the dressing as directed.
- Ask your doctor about when it is safe to shower, bathe, or soak in water.
- Be sure to follow your doctor's instructions.
Call Your Doctor
- Severe or unusual pain that is not relieved by pain medicine
- Signs of infection, including fever and chills
- Redness, swelling, increasing pain, excessive bleeding, or discharge from the incision site
- Cough, shortness of breath, or chest pain
- Numbness and/or tingling in the injured extremity
- Loss of movement in the fingers or toes of the injured arm or leg
- The cast feels too tight
- Burning or stinging sensations under the cast
- Redness of the skin around the cast
- Persistent itching under the cast
- Cracks or soft spots develop in the cast
- Chalky white, blue, or black discoloration of fingers, toes, arm, or leg
American Academy of Orthopaedic Surgeons http://www.aaos.org
American Orthopedic Society http://www.sportsmed.org
Canadian Orthopaedic Association http://www.coa-aco.org
Canadian Orthopaedic Foundation http://www.canorth.org
American Academy of Orthopaedic Surgeons website. Available at: http://www.aaos.org . Accessed September 2, 2009.
Setting a broken bone without surgery (closed reduction). University of Michigan Health System website. Available at: http://www.med.umich.edu/1libr/aha/aha%5Fclored%5Fcrs.htm. Updated January 2008. Accessed September 2, 2009.
10/30/2009 DynaMed's Systematic Literature Surveillance https://dynamed.ebscohost.com/about/about-us : Gosselin RA, Roberts I, Gillespie WJ. Antibiotics for preventing infection in open limb fractures. Cochrane Database Syst Rev. 2009;(4):CD003764.
Revision Information
- Reviewer: Michael Woods, MD
- Review Date: 09/2013 -
- Update Date: 09/30/2013 -


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The Indiana State Bar Association recently announced the 2014 class of its Leadership Development Academy. The lawyers are accomplished legal practitioners who have been admitted to practice for less than 15 years. The Academy is a statewide leadership program established to empower and develop lawyers to be informed, committed and involved so that they may fill significant leadership roles in local and state bar associations, local communities and organizations and to serve as role models in matters of ethics and professionalism.
The 25 members will participate in five sessions featuring professional facilitators and prominent speakers from various disciplines to inform participants about leadership principles and techniques, the importance of effective leaders in organizations to maximize efficiency and effectiveness, and the challenges and rewards of leadership in action.
Members of the 2014 Leadership Development Academy are as follows: Daniel L. Askren, Attica; Gary T. Banet, New Albany; James R. Blaufuss, Indianapolis; Brent R. Borg, Fishers; Rebecca L. Buitendorp, Valparaiso; Cynthia V. Carrasco, Indianapolis; Laura B. Conway, Indianapolis; Daniel P. Cory, South Bend; Sarah B. Dauer, Evansville; J. Beau Dial, Evansville; Erica K. Drew, Indianapolis; Noah L. Gambill, Terre Haute; Aimee M. Gong, Indianapolis; Angka E. Hinshaw, Indianapolis; Brandon M. Kimura, Indianapolis; Robert W. Kistler, Fort Wayne; Andrea N. Kochert, Indianapolis; Nicolette E. Mendenhall, Indianapolis; Laura Paul, Indianapolis; Brianna J. Schroeder, Indianapolis; Andrew L. Teel, Fort Wayne; Edward D. Thomas Sr., Indianapolis; LaKesha D. Triggs, Indianapolis; Victoria R. Wolf, South Bend; and Elizabeth J. Wysong Berg, Indianapolis.

subset: commoncrawl


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Nicole's Q & A
Who's your favorite sports team, and why?
Basketball- Warriors Baseball- Giants Football- 49ers I love my Bay Area teams. It helps that they're all Championship teams. Well we are still working on the Warriors but at least all my teams go to the playoffs.
What's your favorite movie quote?
"No, I like to rock n' roll all night and *part* of every day. I usually have errands... I can only rock from like 1-3." -Role Models
What's your favorite video game, and could you kick our butts at it?
I love fighting games like, Tekken, Street Fighter, and Marvel Vs. Capcom. Could I kick your butt at it? Why yes I can! I got a little nerd in me.
Piercings/Tattoos (How many? Where?)
No tattoos and I only have my ears pierced. I'm different, I know.
What's the most embarrassing song on your iPod?
Depends on what you consider embarrassing lol. But it would have to be "Call me Maybe" and "Party in the USA" only reason why its embarrassing is because I can't help but to embarrass myself by singing and dancing to those songs. I get down!
What's your best party trick?
I know almost all the words to like every song. It's impressive.
What's the most memorable pick-up line you've ever heard?
"Do you know how much a polar bear weighs? Enough to break the ice." or "Wow we should have babies" That one freaks me out!!! Who wants to breed as soon as you meet them?
What's the worst job you've ever had?
I would have to say that my worst job would have to have been when I was a referee for youth basketball games back in high school. It was hilarious but those parents could get pretty intense! They would yell at me for bad calls and for laughing on the court. But that job was not that bad, but it's the worst out of my other jobs.
What's the most dangerous thing you've ever done?
Jump off a cliff in Hawaii (where I was born) into the ocean. I missed the wave and when I jumped I hit the bottom of the ocean! That sh*t hurt so bad!!! I would do it again though.
It's 4AM after a crazy night out – what are we eating?
PHO' ! I love noodles and the perfect thing to eat after a night of drinking is Pho'. It's Vietnamese noodle soup. The best thing ever for preventing or curing a hangover.
What's the strangest thing in your fridge right now?
Probably that old milk I need to throw out. Besides that I love Asian food (I'm part Chinese) so I have a bunch of random items that my roommate thinks is weird but I think it's normal.
What's the naughtiest thing you've ever done in public?
I used to sneak off before my games (volleyball, softball) and mess around a bit with this guy I was seeing. It was good luck so I would do that before every game. I had a pretty high batting average.
What do you feel sexiest wearing?
Thigh high stockings, and booty shorts, with a bra that matches. It's one of those "I'm sexy and I know it" outfits and when you look in the mirror you just have to scream "I work out" because you know you look good.
Tell us a joke.
My nick name is Giraffe Booty... Now that's pretty funny.
Special thanks to Hyde Beach in Miami, FL


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Ezstay Taipei 2 @ Nanyang
Located only 3 minutes away from the Taipei Main Station,
Just an easy direct bus from the Taiwan Tao-Yuan International Airport, our hostel is easily accessible and it is centralized location makes it easy to explore.and there are many cheap restaurant and stores around here.
Ezstay Taipei 2 @ Nanyang St. is located only 3 minutes away from the Taipei Main Station. we have 4rooms (2private rooms , female dorm and Mix dorm).our private room is Japanese style 'Tatami' room, and our dorm rooms have curtain on every beds, keep your private space. All of our rooms are equipped with FREE Wi-Fi, air-conditioning.
*we promise our public area feel confortable , reclining area, working area, discussion area.
safety,cleanliness and comfort and friendly staff .
* Free Public Computer
* 24-hour hot shower and Air condition
* No Curfew
Availability & RatesTo view availability and prices please select dates and click 'Update Dates'
Hostel Facilities & Policies
- Adaptors
- Air Conditioning
- Credit Cards Not Accepted
- Free City Maps
- Free Internet Access
- Free Wifi
- Hot Showers
- Internet Access
- Laundry Facilities
- Linen Included
- Lockers
- Luggage Storage
- Meeting Room
- Taxes included
- Tea/Coffee Making Facilities
- Towels Included
- Washing Machine
Cancellation PolicyThis property has a 1 day cancellation policy. Failure to cancel within this time will result in a cancellation charge equal to the first night of your stay.
Must-Read Hostel InfoThis property has specific Terms & Conditions.
* Check-in time 12:00
* Check-out time 12:00
* reception open time 10:00-22:00
* If you arrive earlier our open time, please leave luggage at the reception and come back after noon .
* If you arrive later our open time, please ask us in advance. we can tell you how to check in .
DirectionsShow MapHide Map
From Taoyuan airport: take a shuttle bus to Taipei Main St. - tai bei che zhan. It costs about 130 TWD and takes 50 minutes.
From Songshan airport, take the MRT to Taipei Main Station (25 TWD, 15 minutes)
Taipei Main Station exit M8, turn left on Gong Yuan Road and walk straight. When you see Macdonalds, turn right at Xin Yang Street. Walk 50m, you can find 'Family Mart', 'Watsons' and Post Office on the corner. Turn left and walk 30m, the bright green entrance of our hostel is at the left side, push the glass door and go up to 4th floor.
Located Near
We are located just near the Main Station. It's very convenient to take MRT, Local Train and High Speed Railway. You can access any place in the city, including night markets, several museums and suburbs.
There are many cheap restaurants, stores and food/drink stalls around our hostel. Its Taiwan food is all around.
National Museum is just at the end of the street, busy Ximen area is within a walking distance, Contemporary art museum is on the other side of the Train Station.


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From WENN.com
The Hollywood star was due to begin working on Queen of the Desert, starring as writer Gertrude Bell alongside Robert Pattinson as British Army officer T.E. Lawrence.
However, Watts reveals the project is currently on hold, as she wants to be around more for her two young sons with actor partner Liev Schreiber.
She tells EOnline.com, ""(Queen of the Desert) is still a way's off. I don't know yet. Hopefully, it will happen. I just can't travel again right now because I did a lot of travelling last year. It's been a big year and it's time for me to be home with the kids.""
Watts admits her schedule will be hectic as she prepares for the upcoming Academy Awards ceremony, where she is nominated for Best Performance by an Actress in a Motion Picture (Drama) for her turn in disaster epic The Impossible.
Talking about her Oscars gown, she adds, ""It's kind of endless hours that you have to put into it, in terms of fittings and second fittings and more.""


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The Fort Douglas Living History Detachment Civil War Re-Enactors
Main Library
1,839 people like this -Like
Before Will Bagley's lecture, A Terror to Evil-Doers, in the Main Library Auditorium, Civil War re-enactors from The Fort Douglas Living History Detachment will be on Library Square from noon to 3pm. Immediately preceding the lecture (2:45pm), participate in an Abraham Lincoln look-alike contest with a prize for the best Lincoln!
This program is part of the American Histories series at The City Library, preceding the arrival of the American Library Association's traveling exhibit Lincoln: The Constitution and the Civil War, highlighting important historical elements from one of the most significant periods in our nation's history.
Location: Library Square
Contact Information: (801) 524-8200


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Narrow your search
Create and print a monthly calendar by choosing a year and month, and schedule your activities.
An intuitive interface makes Sunrise Calendar one of the best free calendar apps that's available on multiple platforms.
Pricing not available
While it's currently iPhone-only, Tempo Smart Calendar is a worthwhile calendar app that integrates well with other services.
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Peek Calendar has a great-looking interface, but too many missing features make it a download worth skipping for now.
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While the official Google Calendar app is decidedly basic, it is likely still an upgrade over the stock calendar app on your device.
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Fantastical 2 has replaced the Calendar app on my iPhone, and I don't see that ever changing. Managing my schedule, along with Reminders integration have made it a "must have" app.
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Download Cal for its unique, photo-focused design, and solid event planning features.
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Download Cal for its unique, photo-focused design, and solid event-planning features, but skip it if you need more control over your calendar.
Typical price: $0.00
You can view between one and seven days in the week view of Apple's Calendar application, but this can only be accessed using a hidden hotkey.
Let's face it, the calendar app that came with your phone isn't always the best choice for managing your schedule. Replace it with one of these pretty and helpful alternatives.
Sunrise adopted the look and feel of iOS 7 early on, and did it well.


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FDP ContactsMailing Address:500 Fifth Street, NWWashington, D.C. 20001Tel: (202)334-3994Fax: (202)334-1369E-mail: email@example.com
FDP Brochure 2012
"The University community has a crucial role to play in support of the President's goals for stimulating innovation and competitiveness in science and technology and developing the next generation of scientists and engineers. The Federal Demonstration Partnership provides a valuable forum through which Federal science and technology agencies can work creatively with University partners to reduce administrative burdens while advancing scientific discoveries and increasing transparency and accountability."
- Dr. John Holdren, Director, Office of Science and Technology Policy
The Federal Demonstration Partnership is a cooperative initiative among 10 federal agencies and 119 institutional recipients of federal funds for Phase V. Our Chair and Vice-Chair are Dr. Susan Sedwick from the University of Texas at Austin and Dr. Sandra Schneider from the University of South Florida. The FDP is a program sponsored by the Government, University, Industry Research Roundtable of the National Academies. Its purpose is to reduce the administrative burdens associated with research grants and contracts. The interaction between FDP's 300 or so university and federal representatives takes place in FDP's 3 annual meetings and, more extensively, in the many collaborative working groups and task forces that meet often by conference calls in order to develop specific work products.
The FDP is a unique forum for individuals from universities and nonprofits to work collaboratively with federal agency officials to improve the national research enterprise.Learn more... The Government-University-Industry Research Roundtable (GUIRR) provides a platform for leaders in science and technology from government, academia, and business to discuss and take action on scientific matters of national importance. These include issues facing partnerships between government, universities, and industry, the academic research enterprise, training of the scientific workforce, the effects of globalization on U.S. research, and others. More about GUIRR...
Evolution of the FDP1985—Pre-FDPHearings convened by the Government-University-Industry Research Roundtable (GUIRR) on "Reducing Bureaucratic Accretion" in government and university sponsored research systems.
1986—FDPCreation of the Florida Demonstration Project to develop and test new grants management procedures. Founding members are five major federal research and development agencies (DOE, NSF, NIH, ONR, USDA), the Florida State University System, and the University of Miami.
1988—FDP IIExpansion through a competitive process to include 45 institutions in 14 states and 10 federal agencies; renamed the Federal Demonstration Project, Phase II.
1996—FDP IIIDesignated the Federal Demonstration Partnership, Phase III, membership broadens to include an additional 20 institutions, one federal agency, and seven professional associations. Increased faculty participation is realized, bringing an exciting new dimension to the partnership.
2002—FDP IVFederal Demonstration Partnership, Phase IV, target efforts are being undertaken to increase the participation of minority serving institutions and emerging research institutions. On the institutional side, the activities of the faculty representatives have become more focused and more closely interwoven into the fabric of the FDP. On the federal side, more federal auditors and costing officials are involved in task forces and committees working to reduce administrative burden.2008—FDP VFederal Demonstration Partnership, Phase V, current projects include the STAR metrics pilot, A-133 subrecipient monitoring, effort reporting pilot, Grants.gov, JAD team, second faculty burden survey, and administrative burden reduction.
Congressional Hearing on Administrative Workload in Federally Sponsored ResearchCLICK HERE to view FDP Chair, Dr. Susan Wyatt Sedwick and Dr. Arthur Bienenstock's Congressional Testimony, Thursday, June 12, 2014. Click here to download the written testimony of Dr. Sedwick and here to download the summary of the written testimony.Uniform Guidance White PapersThe FDP has published a set of white papers investigating areas of concern in the implementation of the new uniform guidance on administrative requirements. Click here to download the white papers.Faculty Workload Survey Report IssuedThe final report from the Faculty Workload Survey has been published. Click here to download a copy of the full report or here to download a copy of the Executive Summary..
September 10-12, 2014 The Grand Hyatt Washington 1000 H Street, NWWashington, DC 20001CLICK HERE to Register and Book HotelDRAFT Agenda 2015 Meeting Dates:January 11-13, 2015, Hyatt Capitol HillMay 10-12, 2015, Hyatt Capitol HillSeptember 2-4, 2015, Hyatt Capitol Hill2016 Meeting Dates:January 10-12, 2016, Hyatt Capitol HillMay 4-6-, 2016, Hyatt Capitol HillSeptember 21-23, 2016, Hyatt Capitol Hill


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Dennise's Q & A
Who's your favorite sports team, and why?
Longhorns of course. I lived in Austin, Tx for a few years and loved everything about it. I have to represent UT!
What's your favorite movie quote?
"Life moves pretty fast. If you don't stop to look around once in a while, you could miss it."
What's your favorite video game, and could you kick our butts at it?
I'm such a nerd when it comes to video games. My all time favorite video game would have to be any of the Tekken series which are a fighting/arcade genre. I am invincible and will kick anyone's butt at it any day!
Piercings/Tattoos (How many? Where?)
Two piercings on each ear and one in my belly button. I formerly had my tongue pierced but removed it due to how uncomfortable it became to consume food. As far as tattoos go, I love the way they look but naked skin is more my style.
What's the most embarrassing song on your iPod?
In between all the rock songs on my iPod the silliest song lingering is Wannabe by Spice Girls. I wouldn't call it embarrassing just silly. It's a classic. Haha.
What's your best party trick?
Having fun all the while keeping classy not trashy.
What's the most memorable pick-up line you've ever heard?
"My phone seems to be missing your number." I laughed. Pick-up lines are so lame.
What's the worst job you've ever had?
As a receptionist at a hair salon. That's where I learned people are difficult to please. Not to mention the screaming children who would get their hair cut would yell so loud it would practically make my ears bleed.
What's the most dangerous thing you've ever done?
As a child I jumped from the roof of a second floor, over a gap separating the houses on to the roof of the house next door just for fun.
It's 4AM after a crazy night out – what are we eating?
Whataburger. It's ritual.
What's the strangest thing in your fridge right now?
Bread. I'm not sure why it's in there.
What's the naughtiest thing you've ever done in public?
Too naughty to say. Lets just say it involved a stairway and almost getting caught by teachers.
What do you feel sexiest wearing?
Definitely my workout clothes.
Tell us a joke.
Knock knock.


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You will see a watermark in the bottom right corner of all our images, however, that will not appear on your product when you order it.
Crawdaddy! was the first U.S. magazine of rock music criticism. Dawning before the rise of both Rolling Stone and Creem magazines, Crawdaddy! was conceived by a 17-year-old Paul Williams in his dorm room at Swarthmore College. Crawdaddy! caught on quickly and grew from a fanzine to a full-fledged magazine with newsstand distribution. It is remembered by many as the true voice of rock 'n' roll.


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| Subject to Credit Approval
"Customer service is priority #1 at Rocky Mountain ATV/MC. We value our customers and strive to be the best shopping experience- when you buy from us, you are buying lifetime service."
-Dan Thomas, CEO and Founder
We take pride in offering no hassle returns. In the event of a return, please call, email or chat with us to receive a solution to the problem. For apparel that doesn't fit quite right, Click here to see our Fit Guaranteed Program.
We will stand behind all products we sell with regards to manufacturing defects in workmanship and material. Most products are limited to the manufacturer's warranty. However, we will do everything in our power to take care of the problem.
Live chat: Click here
(Leave email if after hours)
Call us: 1 800 336-5437
7am-7pm Mon-Fri 8am-4pm Sat (Mountain Standard Time)
Each review submitted enters you into a $100 gift card monthly drawing, and a $500 gift card quarterly drawing!
Comments On Jun 09, 2014:Nice look goods
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Comments On Jan 27, 2014:works fine and it was free
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Comments On Dec 27, 2013:Excellent flag to have as a backup in the event you lose your main flag. Love to advertise for the company as well!!
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Comments On May 31, 2013:cheap and easy to install
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Comments On Jan 29, 2013:If you can't get a freebie from your dealer as you should so you can advertise for them for free........you might as well buy one from your favorite parts supplier and advertise for them. After all you do save a lot of money buying from Rocky Mountain and their flags are inexpensive so if you have to buy one you might as well buy and fly theirs.
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Comments On May 01, 2012:Poor design save your money.
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Comments On Dec 28, 2010:the flag worked very well, & it served its purpose
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Comments On Oct 26, 2010:Great idea to be able to break it down into two pieces. Dont do it. The coupling that mates the two pieces together is steel which adds weight. If you go over any kinds of whoops, the flagpole swings frontward and backward beating you in the helmet. The metal coupling acts as a pendulum.
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Comments On Sep 22, 2010:I really like the two piece design of this product, it allows ease of transportation because you don't have a 6 or 7 foot flag tucked away or hanging out. However, the actual flag has difficulty staying on. If you buy this put some tape or a zip-tie above the flag otherwise you may lose it in the dunes. Other than that minor inconvenience it's a great product at a fair price!
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Comments On Jun 23, 2010:Broke after about 7 minutes and 0 crashes. Had it mounted in bracket and everything and it busted at the mounting nut. Save your money and get a big diameter pole and a spring mount. Spent the whole weekend fighting with broken flags.
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Have questions about what it's like to go through the Founder Institute? Then join us for an upcoming Online Graduate Q&A Panel, where you can learn about the program from entrepreneurs who launched their companies through the Founder Institute program.
The next Online Graduate Q&A Panel is scheduled for Wednesday, March 19th, at 5pm PDT (see local time).
The Founder Institute has over 1,000 graduate companies, and they have gone on to create over 10,000 new jobs across the globe. On this interactive webinar, you can ask graduates any questions you have. For example, how hard is it to get through the program? What are some insights on how to be successful in the program? What are some tactics to build a successful company once you graduate?This webinar will be hosted by Adeo Ressi (Founder & CEO of the Founder Institute), and include the following Founder Institute Graduates;
- Mike Galarza, Founder & CEO of Entryless, and Silicon Valley Founder Institute Graduate
- Neil Smith, Founder of Slidefish, and Sydney Founder Institute Graduate
- Suzanne Wouk, Founder & CEO of SnapPost, and Silicon Valley Founder Institute Graduate
Who should Attend?
- Anyone interested in the learning about Founder Institute program
- Anyone who wants to understand the experience of going through a top global incubator
- Anyone interested in understanding how an accelerator can help with the idea or business
What is the Agenda?
- Welcome
- Graduate Overview
- Questions and Answer with Graduates
- Final Remarks


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Fire crews say a woman's car burst into flames overnight in her east Toledo home, destroying her car and garage.
The fire started just after midnight in the 600 block of Reineck Drive. The homeowner says she woke up to the sound of an explosion coming from her garage. Another woman inside the home says she woke up to her small dog barking when she too heard an explosion coming from the garage.
By the time firefighters arrived, the entire garage door was completely burned through, as well as the woman's 2012 Jeep Compass. The 2012 Jeep Compass was recalled due to faulty fuel tank vales because they increase the risk of fire.
Flames from the fire traveled up portions of the home's roof, but fire crews were able to put out the fire before it could destroy the entire home.
An investigator was called out to the scene by officials to try and figure out what caused the woman's car to explode.
Mobile users, click on the "Video" button in the app to watch this story. Download our app here.
Copyright 2013 Toledo News Now. All rights reserved.
730 North Summit Street
Toledo, OH 43604
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Things to see and do - London
Leaving for Great Britain
London :
Unmissable tourist sites
Where to sleep?
London Hotel tips
London Marriott Hotel County Hall from221 £Book
Park Plaza Westminster Bridge London from144 £Book
Premier Inn London County Hall from106 £Book
London Leisure tips
- 61.0 €
- Book
The Original London Sightseeing Tour: Hop-on Hop-off
- 33.0 €
- Book
Paris Rail Day Trip from London
- 212.0 €
- Book
London Travel guide
London : Michelin's recommendations
For London to give up its deepest secrets, it is vital to understand its constant intermingling of past and present. Always known as a lively and dynamic capital city, there has been a renewal of vitality to accompany its entry into the 21st century: the new Tate Gallery; the renovation of the Thames South Bank yet still the Changing of the Guard. Crossing the town from East to west on the Jubilee Line or going up in the London Eye and you will see that London is a town that really moves.
Tourist attractions London : Things to see and do
Palace of Westminster
st. Abingdon GB - London SW1
With Big Ben soaring above it, the Palace of Westminster bewitched Monet, who was inspired to paint one of his most famous series of paintings by the combination of monumental stonework, river and sky. Cradle of British democracy, it is composed of t..
Westminster Abbey: Henry VII Chapel
Westminster Abbey GB - London SW1P 3PA
Built at Henry VII's behest in the early 16C, this magnificent chapel is a fine example of the Perpendicular style. The pillars support magnificent fan vaulting on projecting keystones separated by a network of slender ribs. The entrance has bronze g..
Westminster Abbey
20 Dean's Yard GB - London SW1P 3PA
Necropolis of sovereigns, pantheon of national glories, masterpiece of Gothic art, Westminster Abbey's twin towers push up into the London sky and have looked down for centuries on the setting of great royal ceremonies. Its dimensions are impressive ..
Hotels London
The Sanctuary House Hotel
33 Tothill Street GB - London SW1H 9LA
Prix Prices from : 150 £
The Sanctuary House is a fine hotel in one of London's oldest and most fashionable areas. It is a short walk from Westminster Abbey and Houses of Parliament. The Fuller's pub on the ground floor is traditional, smart and modern. The food is home-coo..
Park Plaza Westminster Bridge London
Westminster Bridge Road GB - London SE1 7UT
Park Plaza Westminster Bridge London is set opposite the Houses of Parliament and Big Ben, on the South Bank. It is close to the London Eye, the Aquarium, restaurants and theatres. The large, contemporary air-conditioned rooms have modern luxuries, ..
London Marriott Hotel County Hall
London County Hall, Westminster Bridge Road GB - London SE1 7PB
With fantastic views of Big Ben and the River Thames, this historic 5-star Marriott hotel boasts a swimming pool and relaxing spa. Its spacious rooms include luxurious bathrobes and Egyptian cotton sheets. Guests get 1 hour of free Wi-Fi in the publ..
Leisure activities London
Experience the essential introduction to London aboard the original hop-on hop-off sightseeing tour. You'll see all the magical sights of London in a comfortable and secure environment, above the crowds at street level aboard our open top buses. Get ..
Prices from : 103 €
Don't leave London without taking this best-selling tour to Windsor Castle, Stonehenge and Bath, England's most beautiful Georgian city. Your day trip includes entrance to Windsor Castle, Stonehenge and Bath's Roman Baths and Pump Rooms. Pop in yo..
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Restaurants London
Anchor & Hope
36 The Cut GB - Southwark SE1 8LP
As popular as ever thanks to its congenial feel and lived-in looks but mostly because of the appealingly seasonal menu and the gutsy, bold cooking that delivers on flavour. No reservations so be prepared to wait at the bar.
Princess of Shoreditch
76-78 Paul St GB - Shoreditch EC2A 4NE
There has been a pub on this corner site since 1742 but it is doubtful many of the previous incarnations were as busy or as pleasant as the Princess is today. The best dishes are those with a rustic edge, such as goose rillettes or chicken pie.
130 Lauriston Rd, Victoria Park GB - Hackney E9 7LH
Sourdough is from the local baker; the butcher and fishmonger are within walking distance. Dishes like pearl barley and feta risotto demonstrate the kitchen's confidence and ability; prices are good and Sunday lunch a languid affair.
Fox and Grapes
9 Camp Rd GB - Wimbledon SW19 4UN
Owned by Claude Bosi, chef-owner of Hibiscus, and run by Cedric, his brother. They may be French but they know about 'proper' pub food, from Cumberland sausages and prawn cocktail to wild boar scotch egg. Three cosy bedrooms also available.
Drapers Arms
44 Barnsbury St GB - Islington N1 1ER
Anyone unfamiliar with Britain's bounteous larder should get along to this down-to-earth Georgian pub to enjoy ingredients like lamb's tongues, smoked eel, blade steak and rabbit in dishes that are satisfying, gutsy and affordable.
Canton Arms
177 South Lambeth Rd GB - Stockwell SW8 1XP
An appreciative crowd of all ages come for the earthy, robust and seasonal British dishes which suit the relaxed environment of this pub so well. Staff are attentive and knowledgeable.


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FDA Advisory Committee Suggests Changes to ESA Use
An advisory committee to the Food and Drug Administration (FDA) has recommended that the agency consider adding new restrictions on the use of antianemia drugs in cancer patients with chemotherapy-induced anemia. The advisory committee's May 10 meeting was the most recent stage for debate about what has become a matter of significant concern: whether use of a blockbuster class of drugs that reduces the need for blood transfusions in the estimated 450,000 cancer patients who receive them annually could be putting them at a greater risk of death.
None of the recommendations offered by the agency's Oncologic Drugs Advisory Committee (ODAC) were highly specific. The committee did, however, advise FDA to evaluate all available and forthcoming data to determine if the use of these drugs, often called erythropoiesis-stimulating agents (ESAs), should be limited in patients with certain tumor types; whether a specific hemoglobin level to trigger the drugs' use in asymptomatic patients should be established; and whether limits should be placed on their use within a certain time frame after chemotherapy is completed. Read more
Celebrating Women's Health
As we are all aware, last Sunday was Mother's Day. Fittingly, it was also the first day of National Women's Health Week, an annual opportunity to educate women about important health screenings and to encourage them to take advantage of every opportunity to prevent diseases like cancer.
Now in its eighth year, this federally sponsored event particularly emphasizes mammography, which - along with adjuvant chemotherapy - was responsible for a 24-percent reduction in breast cancer mortality between 1990 and 2000, according to an NCI-funded study published in 2005. Read more
FDA Advisory Committee Suggests Changes to ESA Use
An advisory committee to the Food and Drug Administration (FDA) has recommended that the agency consider adding new restrictions on the use of antianemia drugs in cancer patients with chemotherapy-induced anemia. The advisory committee's May 10 meeting was the most recent stage for debate about what has become a matter of significant concern: whether use of a blockbuster class of drugs that reduces the need for blood transfusions in the estimated 450,000 cancer patients who receive them annually could be putting them at a greater risk of death.
None of the recommendations offered by the agency's Oncologic Drugs Advisory Committee (ODAC) were highly specific. The committee did, however, advise FDA to evaluate all available and forthcoming data to determine if the use of these drugs, often called erythropoiesis-stimulating agents (ESAs), should be limited in patients with certain tumor types; whether a specific hemoglobin level to trigger the drugs' use in asymptomatic patients should be established; and whether limits should be placed on their use within a certain time frame after chemotherapy is completed.
ODAC Chair Dr. S. Gail Eckhardt, from the University of Colorado Health Sciences Center, stressed that the committee should not be looking to return to the "dark ages" when transfusions of red blood cells were the primary supportive care options for anemic cancer patients. Rather, she said, the goal was to determine how to "move forward" given the safety concerns about ESAs prompted by several clinical trials completed over the last 4 years.
The results of one of those trials were presented just 3 weeks ago at the American Association of Cancer Research (AACR) annual meeting. The nearly 1,000-patient phase III, double-blind, randomized, placebo-controlled clinical trial - called the "103 study" - showed an increased mortality risk in cancer patients with a variety of tumor types who were given the ESA darbepoetin alfa (Aranesp), one of two FDA-approved ESAs manufactured by Amgen.
In early March, based largely on the 103 study results and some preliminary data from a Danish trial called DAHANCA 10 that suggested safety concerns, the FDA, among other measures, issued a public health advisory and added a new "black-box" warning to the ESAs marketed in the United States.
Of the clinical trials that have shown an increased mortality risk, only the 103 study's protocol called for using ESAs to achieve the hemoglobin level called for on the drugs' labels, 12 g/dl, explains the trial's lead investigator, Dr. John Glaspy from the UCLA Jonsson Comprehensive Cancer Center. The other ESA clinical trials that have shown a mortality risk were all designed to achieve hemoglobin levels in the 13 to 15 g/dl range - what Amgen representatives referred to as "beyond anemia correction" studies; in two of the trials, patients did not even have to be anemic to enroll.
The 103 study, which did not have survival as its primary endpoint, was also different from the other trials because it involved patients whose anemia was associated with their underlying cancer, for which no benefit of an ESA has been established.
"It's very appropriate to be cautious and do the additional work to run this down, because it's a patient safety issue," says Dr. Glaspy, who also spoke during the meeting on Amgen's behalf. "But I believe that at the end of the day, when used the way we've been using these drugs in oncology, they will be safe."
Amgen representatives also presented preliminary data from the recently completed, 600-patient "145 study," a randomized, double-blind trial in which patients with small-cell lung cancer were treated to a hemoglobin target of 13 g/dl. Patients treated with darbepoetin alfa had equivalent overall and progression-free survival compared with those given placebo.
Although the design and conduct of most of the trials that have exhibited a safety concern have come under intense criticism, says Dr. David P. Steensma from the Division of Hematology at the Mayo Clinic, "I think we have enough evidence now to suggest there is a problem."
During the meeting, ODAC members expressed dismay at the lack of simple trials involving ESAs with a progression-free or overall survival endpoint and the lack of data on ESAs' effects on tumors. They also criticized the direct-to-consumer TV ads for ESAs that suggest they improve problems like fatigue and quality of life, which are unapproved indications in the United States.
By Carmen Phillips
Celebrating Women's Health
As we are all aware, last Sunday was Mother's Day. Fittingly, it was also the first day of National Women's Health Week, an annual opportunity to educate women about important health screenings and to encourage them to take advantage of every opportunity to prevent diseases like cancer.
As the recently released NCI Women's Health Report demonstrated, NCI and the cancer community have much to be proud of in breast cancer research and beyond. Yet we also have a tremendous amount of work to do. Articles in this week's issue touch on both accomplishments and needs.
We are continually striving to bolster the effectiveness of breast screenings. An NCI-funded study, for example, demonstrated that digital mammography may be superior to standard film mammography for women with dense breasts. More recently, it was shown that adding an MRI scan to the standard diagnostic workup following a diagnosis of breast cancer can detect nearly all contralateral breast cancers missed by mammography.
Unfortunately, as the results of an NCI-led study released just yesterday reveal, progress does not preclude the need for continued diligence. The study showed a recent decrease in mammography rates, a drop that includes women most likely to benefit. National Women's Health Week provides an ideal opportunity to remind women about the potentially life-saving importance of regular cancer screenings including colonoscopy, skin exams, and Pap tests.
We are also well aware that the leading cause of cancer deaths in women is lung cancer - a source of significant concern and a high-priority issue for NCI. The NCI lung cancer Specialized Program of Research Excellence at the University of Pittsburgh, for instance, is investigating whether estrogen receptors may play a role in women being more prone than men to getting a more aggressive form of lung cancer.
One of the most exciting advances in women's health was the approval last year of the HPV vaccine Gardasil. Recently released data suggest that Gardasil and another investigational HPV vaccine are safe and confer long-term protection against these HPV types. Meanwhile, the NCI researchers whose work led to the development of these first-generation vaccines are collaborating with researchers from Johns Hopkins University on a second-generation vaccine intended to protect against more HPV types.
Along those lines, a study published last week demonstrated that HPV-16 infection was an independent risk factor for oropharyngeal cancer, suggesting the strides being made toward preventing cervical cancer could offer unexpected benefits in another area of cancer prevention - a hallmark of quality research.
Findings from another NCI-supported study led the institute last year to take the rare step of issuing a clinical announcement, advising oncologists about the superiority of intraperitoneal chemotherapy in the treatment of advanced ovarian cancer.
Far too often, though, ovarian cancer isn't detected until it has reached an advanced stage and is far more difficult to treat. In response, NCI has launched the Ovarian Cancer Early Detection Program genetics and screening study to, among other things, identify women at increased risk for developing ovarian cancer and identify and develop highly sensitive and specific tumor markers for the detection of early-stage ovarian cancer.
These are just some examples of how NCI is helping to improve women's health. I'd like to congratulate the NCI Office of Women's Health for its guidance and leadership in helping to advance research on cancers in women. I'd also like to encourage all women who haven't done so recently to use the interactive check-up wizard on the Women's Health Week Web site and make an appointment with their physician to discuss the appropriate screenings they should receive.
Dr. John E. Niederhuber
Recent Drop in Mammography Rates Causes Concern
The drop in mammography rates in the United States in recent years is cause for concern because it could contribute to a future rise in breast cancer deaths, according to an analysis of data from representative national surveys published early online in Cancer.
Scientists from NCI's Division of Cancer Control and Population Sciences (DCCPS), led by Dr. Nancy Breen, examined data from the Centers for Disease Control and Prevention's National Health Interview Surveys (NHIS) and found a decline in mammography screening in 2005 compared with 2000 - from 70 percent to 66 percent. After many years of increases in mammography use, "[t]his report establishes for the nation what has already been observed in some local data. It confirms that use of mammography may be falling. Although small, this decline is cause for concern, as it signals a change in direction."
Mammography screening rates were lower in 2005 than in 2000 for nearly all the groups of women examined. "The largest significant declines were among women who have traditionally used mammography at high rates, including the 50-64 age group, those with higher incomes, and women aged 40-64 with private, non-HMO insurance coverage," the DCCPS investigators noted.
When screening rates drop, women with breast cancer will be diagnosed later, resulting in a short-term drop in incidence, they add. "Consequently, we are concerned that some of the observed decline in incidence may be due in part to the leveling off and reduction in mammography rates." The trend "may presage a future increase in mortality from breast cancer" from later detection of more advanced disease. "If future NHIS data continue to show a decline in mammography use, then we as a nation need to be prepared to address it," the NCI scientists concluded.
The recent decline in breast cancer incidence rates was examined in a separate study published May 3 in Breast Cancer Research. Scientists from the American Cancer Society, led by Dr. Ahmedin Jemal, examined data from NCI's Surveillance, Epidemiology, and End Results (SEER) program.
"Two distinct patterns are observed in breast cancer trends," they reported. The downturn in incidence rates in all age groups above 45 years coincides with a plateau in mammography use, which typically reduces incidence rates "due to a reduced pool of undiagnosed cases." The sharp decrease in incidence from 2002 to 2003 that occurred in women 50 to 69 years old who predominantly, but not exclusively, had ER-positive tumors may reflect the early benefit of the reduced use of hormone replacement therapy. A number of investigators within NCI-funded initiatives are now examining the contribution of recent changes in screening and hormone therapy to breast cancer trends.
HPV a Risk Factor for Oropharyngeal Cancer
A new epidemiological study led by researchers from Johns Hopkins University implicates human papillomavirus (HPV) exposure and infection as strong risk factors for oropharyngeal cancer. The results from the case-control study, published in the May 10 New England Journal of Medicine, show that HPV exposure and infection increase the risk of oropharyngeal squamous cell cancer independently of tobacco and alcohol use, two other important risk factors for the disease.
The investigators enrolled 100 patients with newly diagnosed oropharyngeal squamous cell carcinoma and 200 control patients in the study. Oral-mucosal and serum samples were colleted from all patients. Tumor samples were also collected from case patients. The investigators analyzed all collected samples for presence of HPV DNA or antibodies that would indicate prior exposure. Personal and medical history information collected included oral hygiene history, sexual history, and lifetime use of marijuana, tobacco, and alcohol.
Researchers found that "the presence of an oral HPV 16 infection was strongly associated with oropharyngeal cancer." HPV 16 is one of the two strains of HPV most often associated with cervical cancer. Past exposure to HPV 16, as measured by presence of antibodies to the virus in serum samples, was also strongly associated with oropharyngeal cancer. Antibodies against HPV 16 were found in 64 percent of case patients but only 4 percent of control patients. Data collected on sexual history "suggest that oral HPV infection is sexually acquired…but we cannot rule out transmission through direct mouth-to-mouth contact or other means," said the authors.
A history of heavy tobacco and alcohol use remained a strong risk factor, but "combined exposure to HPV and heavy tobacco and alcohol use was not additive," they explained. "It is important for health care providers to know that people without the traditional risk factors of tobacco and alcohol use can nevertheless be at risk for oropharyngeal cancer," stated first author Dr. Gypsyamber D'Souza in an accompanying press release.
New Data from HPV Vaccine Trials Available
Results from an average of 3 years of follow-up from the FUTURE I and FUTURE II clinical trials of Gardasil, a vaccine that protects against the two types of human papillomavirus (HPV) that are responsible for 70 percent of all cases of cervical cancer, have been published in the May 10 New England Journal of Medicine. Earlier data from the FUTURE II trial led to the FDA approval of Gardasil in June of 2006.
The FUTURE I study randomly assigned 5,455 women between the ages of 16 and 24 to receive either a 3-injection course of Gardasil vaccine or placebo. For women who had not previously been exposed to HPV 16 or 18, the efficacy of the vaccine was 100 percent in "preventing vaginal, vulvar, perineal, and perianal intraepithelial lesions or warts associated with the vaccine-type HPV."
In an intention-to-treat analysis, which included women who had previously been exposed to HPV 16 or 18, the vaccine efficacy was 73 percent against all grades of external anogenital or vaginal lesions and 55 percent against all grades of cervical lesions related to those HPV types.
The FUTURE II study randomly assigned 12,167 women between the ages of 15 and 26 to receive either a 3-injection course of Gardasil vaccine or placebo. For women who had not previously been exposed to HPV 16 or 18, the vaccine prevented 98 percent of high-grade cervical intraepithelial neoplasia related to those HPV types.
In an intention-to-treat analysis, which included women who had previously been exposed to HPV 16 or 18, vaccine efficacy was 44 percent against high-grade cervical disease caused by HPV types 16 or 18. As in the FUTURE I trial, "[v]accination did not appear to alter the course of cervical lesions related to HPV 16 or HPV 18 or of infection present at the time of randomization," explained the authors.
The vaccine reduced the rate of all cervical lesions in all patients regardless of prior HPV exposure, including lesions caused by HPV types not included in the vaccine, by 17 percent. "An interim analysis of vaccine trial data submitted to the FDA showed a disproportionate, but not statistically significant, number of cases of grade 2 or 3 cervical intraepithelial neoplasia related to nonvaccine HPV types among vaccinated women," stated Drs. George Sawaya and Karen Smith-McCune from the University of California, San Francisco, in an accompanying editorial. "Updated analyses of data from these ongoing trials will be important to determine the effect of vaccination on rates of preinvasive lesions caused by nonvaccine HPV types."
Additional reliable information from NCI about HPV vaccines and cervical cancer can be found at http://www.cancer.gov/cancertopics/hpv-vaccines.
Hepatitis C Increases Risk of NHL
A large, retrospective cohort study found that U.S. veterans infected with the hepatitis C virus (HCV) have an increased risk of developing certain lymphomas, according to study results published in the May 8 Journal of the American Medical Association.
Dr. Eric Engels of NCI's Division of Cancer Epidemiology and Genetics and colleagues looked at patient records collected from U.S. Veterans Affairs hospitals between 1997 and 2004. Researchers selected 146,394 patients who were diagnosed with HCV infection and 572,293 patients who were not. Researchers matched the two cohorts on age, sex, and baseline visit date and type - inpatient or outpatient.
Patients with HCV infection had a 20- to 30-percent increased risk of developing non-Hodgkin lymphoma (NHL) and a nearly threefold increased risk of developing Waldenström macroglobulinemia - a rare type of NHL. Patients with HCV infection also had an elevated risk of developing cryoglobulinemia - a condition marked by abnormal levels of certain proteins in the blood.
The researchers noted, "Although the clinical significance of these findings is unknown, it is possible that screening of individuals infected with HCV could identify early-stage lymphoproliferative conditions suitable for early intervention strategies, including chemoprevention trials on premalignant disease. Future epidemiological and pathophysiological studies are needed to further explore the relationship between HCV and NHL."
Study Measures Support Group Use by California Cancer Patients
Nearly one in four people diagnosed with cancer have participated in a support group at some time in their lives, NCI researchers report, though only about half of those did so for problems related to cancer. Nonetheless, cancer survivors' 23.7 percent participation rate was much higher than the 14.5 percent of patients with another chronic illness using a support group.
These results come from an NCI study appearing online May 14 in Cancer. Dr. Julia Rowland of NCI's Office of Cancer Survivorship and colleagues say they were surprised to find that only 10.2 percent of cancer patients using a support group were recommended by their physician to do so, given that 78.4 percent of those using such support reported receiving clear and positive benefits.
Both the use of support groups and their perceived benefit varied widely by cancer site. About 26 percent of breast cancer patients had group experience, 78 percent of whom perceived benefit. The highest rate of support group use, 41 percent, was by leukemia and Hodgkin lymphoma patients, with 93 percent of these patients perceiving benefit. Less than 1 percent of lung cancer patients used a group, and those with skin cancer reported the lowest rate of perceived benefit, 35 percent.
The study was conducted using telephone surveys with 9,187 people enrolled in the California Health Interview Survey Complementary and Alternative Medicine. There were 1,844 cancer patients in the survey and 4,951 participants with other chronic health problems.
Do Rare Cancer Cells Have a Tale to Tell?
A somewhat different randomized clinical trial was launched earlier this year in women undergoing their first treatment for metastatic breast cancer. It won't pit a standard therapy against an experimental therapy or a new combination of existing agents, or even an experimental therapy against placebo.
Instead, after a single chemotherapy treatment cycle, participants will undergo a blood test that may help predict whether the chemotherapy is working. Women with test results indicating ineffective therapy will then be randomized to either continue on their current therapy until evidence of progression, which is the current standard of care, or to switch immediately to a different chemotherapy regimen.
"Our goal is to study a strategy of treatment, not the drugs themselves," explains the study's lead investigator, Dr. Jeffrey Smerage from the University of Michigan Comprehensive Cancer Center. "We want to identify early on those patients who will benefit before they suffer significant side effects and toxicity, and increase the likelihood that they'll receive a drug that's active."
The test being used in the NCI-funded clinical trial, which is being led by the Southwest Oncology Group (SWOG), measures the number of tumor cells floating freely among the billions of other cells in the blood, typically called circulating tumor cells (CTCs). Studies in patients with metastatic disease, mostly breast cancer, have found that patients whose CTC count just prior to treatment and in the first few weeks following treatment exceeds a particular threshold - 5 CTCs per 7.5 mL of blood - have far shorter progression-free and overall survival than those who have low or no detectable CTCs at those times.
Although the majority and largest of these studies have been conducted in breast cancer, smaller studies involving patients with melanoma, prostate, and colorectal cancer have yielded similar results.
As the SWOG trial demonstrates, researchers are now trying to determine just how much clinically relevant information can be wrenched from these rare cells, including whether they can point the way to more tailored therapies, serve as surrogate markers for response to treatment in clinical trials, or provide new insights into the cause of more than 90 percent of cancer deaths - metastasis.
What exactly are they saying?
Although several companies have developed tests and investigators around the world continue to refine and improve the CTC detection process, in the United States, Immunicon Corporation's CellSearch assay is the only CTC test to receive FDA clearance to monitor patients with metastatic breast cancer; several studies described in this article used the CellSearch system and were funded at least in part by Immunicon.
Even with some of the optimism surrounding CTCs, says Dr. George Sledge, from the Breast Care and Research Center at the Indiana University School of Medicine, there currently are serious limits to what measuring CTCs can help accomplish.
"My concerns are not over technology itself, but rather what to do with the result once you have it," he says.
Even though measuring CTCs can predict that a treatment isn't working, Dr. Sledge continues, it doesn't tell oncologists which therapy would do better - a critical need in caring for women with metastatic disease, for which there is no current standard first-line regimen.
The SWOG-led trial is a partial step toward determining whether measuring CTCs can, at least, improve the process by which treatment decisions are made. It is based largely on the results of a prospective clinical trial led by Dr. Massimo Cristofanilli at the University of Texas M.D. Anderson Cancer Center. Initial results from the study, published in 2004 in the New England Journal of Medicine, showed that in women with either recurrent or newly diagnosed metastatic breast cancer, CTC levels at baseline and 3 weeks follow-up were the most significant predictors of progression-free and overall survival. When a 2005 analysis was confined only to women undergoing first-line treatment, the results were the same.
The available data - including a pivotal study of women treated for metastatic breast cancer published last year - also suggest that CTCs may be a quicker, more accurate predictor of therapeutic effectiveness than the current gold standard, imaging studies typically performed 10 to 12 weeks after treatment to measure whether tumors have grown or shrunk.
The CTC assay was highly reproducible and reliably predicted disease progression, the study found, both of which have been problems in clinical trials that rely on more standard techniques, says Dr. Sledge.
It's unclear whether CTCs may offer the same prognostic insight in patients with operable, early-stage disease. To date, only a handful of studies have been done in this setting, with some promising results reported.
Writing the next chapter
Dr. Weiner points to a study in which he was involved that focused on patients with metastatic colorectal cancer, one of only a few studies that have attempted to perform gene expression profiling of CTCs.
"There were very few CTCs in most patients," he notes. "It's beginning to appear that measuring CTCs will be most beneficial in cancer types associated with bone marrow involvement, where you would expect to find more CTCs in the peripheral blood and thus be more accessible to the technology."
So far, CTC-related findings have generated more questions than answers. For example, Dr. Weiner notes, it hasn't been resolved whether CTCs are representative of what's happening at the tumor site, are "adventurous metastasis-prone cells, or…have been kicked out of the tumor neighborhood and are preparing to undergo cell death."
It's questions like these that researchers are now trying to answer, undertaking the task of molecularly characterizing CTCs to determine just what their fate may be or how they differ from cells in the primary tumor. For example, in a small German study of 35 women with stage I to III breast cancer, 12 patients with HER2-positive CTCs had HER2-negative primary tumors.
Other evidence suggests that such HER2 "conversions" aren't uncommon. Such information, says Dr. Sledge, "could potentially be useful in guiding treatment decisions or following the fate of a cell population after completing a form of therapy."
Several studies have suggested that some CTCs have properties associated with chemotherapy resistance and could even be another type of rare cell, a cancer stem cell, which a growing body of evidence indicates may fuel several cancers and be responsible for recurrent disease.
Although there is still much work to do, concludes Dr. Cristofanilli, he is hopeful that CTCs may represent a way "to divide cancer into two different types of disease: more aggressive disease and more indolent disease, so we can start to think about how to develop treatments in a different way."
By Carmen Phillips
Resistance to Lung Cancer Drug Linked to MET Gene
A new cause of drug resistance in patients taking the lung cancer drug gefitinib (Iressa) has been discovered along with a strategy for reversing the resistance.
Researchers have found extra copies of a gene called MET in the tumors of some lung cancer patients who stopped responding to gefitinib. Experiments with resistant cells showed that this genetic change - an amplification - can cause the drug to stop working.
Dr. Pasi Jänne of the Dana-Farber Cancer Institute and his colleagues also found that the resistance could be reversed, at least in a cell model. They did this by treating resistant cells with a combination of gefitinib and a compound that inhibits MET.
It is not yet clear whether such a combination therapy will work in patients, but an answer should come in the next few years. Many companies are developing agents that target MET or its partners, and the first such drugs are in early-stage clinical trials.
The MET gene was discovered at NCI in 1984 in the laboratory of Dr. George Vande Woude. It has since been implicated in two dozen cancers.
At least for now, the new results are relevant only to a small subset of lung cancer patients who have mutations in the gene EGFR. (About 10 percent of lung tumors have EGFR mutations.)
Since the findings were announced last month (and reported online in Science on April 26), lung cancer patients have been contacting physicians about the research.
"Patients with cancers involving EGFR mutations should be aggressive in searching out clinical trials with novel approaches to treatment if the initial therapies stop working," says Dr. Jeffrey Engelman of Massachusetts General Hospital, the study's first author.
Most lung cancer patients with EGFR mutations respond well to gefitinib and a related drug, erlotinib (Tarceva), but resistance usually occurs within 2 years. In half the cases, this happens because of new mutations in EGFR or in the genes it controls.
The MET gene, however, is not controlled by EGFR, nor does it normally interact with gefitinib. So before this study, researchers did not suspect that MET played a role in gefitinib resistance.
It now appears that MET and EGFR may be interchangeable members of the same family of kinase genes. Both produce protein receptors that sit on the cell surface and relay messages to the interior, including signals about growth and proliferation.
"The MET receptor plugs into the same signaling network that the lung cancer cells were using," says Dr. Jänne. In effect, MET restores the flow of cancer-promoting signals into the cell.
The question now is how often and under what circumstances the MET amplification occurs, says Dr. John Minna of the University of Texas Southwestern Medical Center, who developed the lung cancer cells used in the study.
He agrees that patients whose tumors progress while they are taking gefitinib or erlotinib should be evaluated for participation in one of the clinical trials testing the new inhibitors.
"We need to bring some MET-targeted drugs into the clinic and see whether or not they are going to work on these tumors with MET amplifications," says Dr. Minna.
Without a cell model of resistance, this research might not have been possible, because tissue samples from patients who develop resistance are extremely rare. After a drug fails, patients rarely have biopsies to determine what caused the failure, yet researchers need these tissue samples to understand how resistance occurs.
"Fortunately, we were able to figure out what was going on in the laboratory and then test the hypothesis on the precious few clinical samples we had," says Dr. Engelman. He obtained 18 samples from patients around the world.
In the future, patients may elect to have biopsies after a drug fails if the resulting information is likely to improve treatment, Dr. Engelman notes. He believes cancer physicians are moving toward an approach to drug resistance pioneered for treating HIV and tuberculosis.
"That means you attack the cancer based on how it would likely become resistant and by doing so you delay resistance and achieve longer term remissions," he says.
By Edward R. Winstead
Dr. Vivian Pinn is associate director for Research on Women's Health and director of the Office of Research on Women's Health at NIH. In 2006, the National Academies Press released a report, Beyond Bias and Barriers, Fulfilling the Potential of Women in Academic Science and Engineering, which showed that women are underrepresented in these academic fields. In January 2007, NIH Director Dr. Elias Zerhouni convened the NIH Working Group on Women in Biomedical Careers to promote the advancement of women in research both at NIH and in the extramural research community. Dr. Pinn co-chairs the Working Group with Dr. Zerhouni.
How can the NIH Working Group on Women in Biomedical Careers address concerns raised in the National Academies report?
What are the immediate goals of the Working Group?
How is your office participating in National Women's Health Week on the NIH campus?
To learn more about the Office of Research on Women's Health, go to http://orwh.od.nih.gov/. Under the section ORWH Presents: Pinn Point on Women's Health, click on Listen to hear what Dr. Pinn and her guest NIH researchers have to say about current topics in women's health. If you need further assistance on how to use podcasts, go to http://www.nih.gov/news/radio/nihpodcast.htm.
Adjuvant Bisphosphonates for Breast Cancer
Name of the Trial
Principal Investigators
Why This Trial Is Important
Drugs called bisphosphonates have been shown to slow the progression of bone metastases and reduce skeletal complications in women with metastatic breast cancer. Bisphosphonates may also prevent the development of bone metastases in newly diagnosed patients with no evidence of metastasis.
"Breast cancer cells stimulate bone cells called osteoclasts, and these osteoclasts in turn stimulate the growth of breast cancer cells," said Dr. Gralow. "A bisphosphonate called clodronate has been shown to interrupt the relationship between osteoclasts and breast cancer cells in early-stage breast cancer. With this trial, we're comparing clodronate with two newer, more potent bisphosphonates - zoledronate and ibandronate.
"If we can eliminate bone as a safe harbor for breast cancer cells in women who would have experienced bone metastases as the first site of metastasis, we may be able to prevent the spread of breast cancer in these women altogether and save lives. Additionally, we hope to determine which types of breast cancer preferentially metastasize to bone," Dr. Gralow added.
Who Can Join This Trial
Study Sites and Contact Information
An archive of "Featured Clinical Trial" columns is available at http://cancer.gov/clinicaltrials/ft-all-featured-trials.
If Memory Serves...
The year before the National Cancer Institute Act of 1937, Marjorie G. Illig of the American Society for the Control of Cancer (predecessor of the American Cancer Society) suggested the creation of a legion of female volunteers. The goal of the Women's Field Army was to raise money for cancer research and to educate the public about cancer. Her recruits wore khaki uniforms with insignia for rank and achievement. In less than 3 years, they helped increase the number of volunteers who were active in cancer control by tenfold. Read more)
For more information about the birth of NCI, go to http://www.cancer.gov/
OWH Updates Web Site
The site highlights NCI-supported research to understand, prevent, diagnose, and treat cancers that affect women only or cancers with a high impact on women. In addition to disease-specific sections, the site features special topics on AIDS-associated malignancies, cancer health disparities, tobacco prevention and control, and a new section addressing cancer survivorship.
Users can subscribe online to the NCI Women's Cancers listserv to receive notices when new content is posted on the site at http://women.cancer.gov/subscribe.shtml. Users can also help improve the site by providing comments at http://women.cancer.gov/survey.cfm.
Vitamin D Conference Held
LCBG Announces Availability of Samples to Validate Lung Cancer Biomarkers
When complete, four reference sets will be available. Two sets will contain retrospectively collected blood samples with clinical annotation, and the other two will contain prospectively collected samples.
The reference sets will be assembled and stored at the NCI facility in Frederick, MD. Any investigator studying promising lung cancer biomarkers can submit an application to the internal LCBG review committee for consideration. The detailed protocol for requesting access to these samples is available at http://edrn.nci.nih.gov/resources/sample-reference-sets.
May is Melanoma Awareness Month
Photographer Wins Pulitzer for Cancer Story
This year Renee C. Byer, a senior photojournalist for the Sacramento Bee, won a Pulitzer Prize for her photo essay, "A Mother's Journey," capturing the story of single mother Cyndie French and her son Derek Madsen's fatal battle with cancer in 2006. The photos can be viewed at http://www.pulitzer.org/year/2007/feature-photography/works/.
For Byer, this was an important story to tell. "Billions of dollars go to cancer research, but very little is available to help families struggling emotionally and financially throughout this medical crisis. I wanted to bring awareness to that fact and also compassion to other families struggling in the same situation."
Byer first met French while on a photo assignment at the Susan G. Komen Race for the Cure on May 7, 2005. French's 11-year-old son Derek had neuroblastoma, a cancer that arises in immature nerve cells and primarily affects infants and children. French described her emotional and financial hardships and invited Byer to meet her son.
Initially, Byer wasn't sure she could photograph their story. "As a journalist, you have to let scenes unfold, especially in this kind of situation where lifeline decision making is taking place. You don't want to interrupt the family's normal pattern of life or alter their state of mind." She was uncertain whether Derek would let his guard down enough for her to do this, and she was afraid of how emotionally invested she might become in their lives.
"It's a tough balancing act between stepping back and being compassionate as a person. But what this family endured is tenfold what I endured, so that is how I could document their story."
For a year, Byer captured their visits to the doctor, grocery store trips, and moments of joy, anger, and sorrow. Now Byer hopes that the photos and Pulitzer Prize will draw attention to Derek's Wish, a foundation that French has started in memory of her son to assist other families who are going through treatment for terminal cancer.
The Pulitzer Prizes were created by journalist and newspaper magnate Joseph Pulitzer through an endowment to Columbia University. Pulitzer regarded journalism as a noble and important profession for its influence on the "minds and morals of the people."
The awards are now funded through a foundation and are awarded each April by the president of Columbia University for outstanding achievements in journalism, upon the recommendations of a voting board. Submissions total more than 2,400 each year for 21 categories. The winners receive $10,000 at a ceremony in May.
Information about financial resources for cancer patients can be found at http://www.cancer.gov/cancertopics/factsheet/Support/financial-resources. NCI's Office of Cancer Survivorship has additional information for cancer patients and their families.
Following are newly released NCI research funding opportunities:
Preapplication for the Molecular Libraries Probe Production Centers Network
This funding opportunity will use the X02 award mechanism. For more information, see http://www.grants.nih.gov/grants/guide/pa-files/PAR-07-368.html. Inquiries: Dr. Ingrid Li - firstname.lastname@example.com; Dr. Carson Loomis - firstname.lastname@example.com
Framework Programs for Global Health
This is a renewal of PAR-06-067 and will use the R25 award mechanism. For more information, see http://www.grants.nih.gov/grants/guide/rfa-files/RFA-TW-08-001.html. Inquiries: Dr. Flora Katz - email@example.com


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- Adult Adventure
- Some Body Parts
- Tools and Tapers
- Straight Barbells
- Accessories
- Curved Barbells
- Replacement Parts
- Captive Bead Rings
- Earlets & Tunnels
- 14k Gold Only
- Ear Plugs
- Segment & Seamless Rings
- Spirals & Claws
- Organics
- Charms
- Hide Your Piercing
- Circular Barbells
- Genuine Diamond Jewelry
- Screwball Rings
- Fixed Bead Rings
High Quality G23 Surgical Titanium High Polish Curved Barbell, with two threaded Synthetic Pearls in place of the regular ball. The top Pearl is 5mm and the bottom pearl is 9mm in size.
Customer Reviews
- Quality Review by Jamie
This piece was great and lasted a couple months, until it fell out one day. It's very beautiful, just make sure it is always tight!
(Posted on 5/24/13)
- Untitled Review by Grey Sadler
Cute, cute, cute!! I purchased a very similar item from another website, but the top pearl wasn't threaded with metal, so it stripped...this one looks to be more durable!! I just wish the bell portion was a little shorter...thanks!
(Posted on 2/29/12)
- Untitled Review by Guest
Great piece of jewelry for my VCH. Its cute and it did definitely enhanced things. The downside is when I was shaving it got caught and chip is snippet off of it.
(Posted on 2/29/12)
- Untitled Review by Guest
I was excited to find this piece and would recommend.
(Posted on 2/29/12)
- Untitled Review by Guest
very pleased would recommend
(Posted on 2/29/12)
- Untitled Review by Katie
This is exactly what I was looking for and when I received it in the mail I was pleasantly surpirsed to see it was even better quality than I had imagined. Its a beautiful piece of jewelry and Russ gives fantastic customer service. He updated me every step of the way of my order and replied very quickly to my emails. I will be using The Chain Gang from now on for all my body jewelry needs.
(Posted on 2/29/12)


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Home-Prepared Dog and Cat Diets Book Available Free
Rather than a pricey new addition, Donald R. Strombeck puts his book online
Photograph by Richard Seagraves.
Please note comments are moderated. After being approved your comment will appear below.
Thanks Lisa! I've just spent an informative half hour skimming through Dr. Stombeck's diets. We adopted Maggie as an adult, and long story short, she simply did not do well on commercial kibbles (skin and urinary tract issues to name two). So I transitioned her to home-cooked (Dr. Pitcairn's diets) and she has been very healthy for the past 8 years. Now though, as a senior, it seems her heart murmur is growing more worrisome. This link is very timely as I have been investigating dietary changes and supplementation for her. So I was particularly delighted to see that Dr. Stombeck offers specialized heart diets for dogs (and cats!)with a detailed explanation of what nutrients are necessary and why. Thank you! This information couldn't have come at a better time.
Submitted by Ann | January 19 2011 | Permalink
Thank you Dr. Strombeck for caring more about our pets than the bottom line!
Many pages in my copy of his book (have had it for years) has serious dog ears (pun intended). I refer to it's excellent content regularly. Great to know I now have an internet source for the material at my fingertips.
Submitted by Linda | January 23 2011 | Permalink
Thanks Dr. Strombeck. This comes at a perfect time for my dog. She's been developing crystals, and I've been wanting exactly this information so I can create a diet for her. It's very good of you to post this information online for us.
Submitted by Danielle WASHI... | February 14 2011 | Permalink
Dr. Strombeck
Submitted by Heather Dent | August 13 2013 | Permalink
I can't seem to find where this book is offered free online. Can you tell me please. My dog has kidney stones and I believe there is a diet and recipes for this condition in his book. I can't really afford this book on my budget and would really like to find it free online.
Submitted by Sue Morgan | May 16 2012 | Permalink
I have the book and it's excellent. With a dog with digestive bowel disease who can't eat kibble this is a wonderful reference and very readable. Thank you, Dr. Strombeck, for making this available.
By the way, there is a reference on line at http://dogloverstoolbox.com/?p=11at that came up on my Goggle search that was not written by Dr. Strombeck. Dr. Strombeck doesn't recommend raw food diets.
Submitted by Elizabeth Lytle | June 2 2012 | Permalink
I am so Grateful and Thankful for this on line book I have been trying to purchase this book however it is so exspensive I was not financially able. So Thank You Thank You Dr. Donald Strombeck for your willingness to share all your widom as well as all the medical information with so many.. I only wish there was way to correspond with questions regarding some of the recipes and exact mounts for larger mounts for a few days of feeding and a weight chart with the recipes.Elizabeth Lytle
Submitted by Lola,Gracie and... | December 20 2012 | Permalink
Thank you from all of us. You have saved our Lola from pain and such horrible kidney disease. We will be forever grateful for your dedication to all of the family pets of the families far and wide.
Submitted by patti | August 3 2013 | Permalink
I am not sure what diet to make, apparently my pup has amorphous cystals with ph of 7 no infections and was put on royal canin so which i hate
Submitted by Jean Hofve DVM | September 12 2013 | Permalink
My much-beloved and well-worn copy of this book has been one of my staples since it was published! I am thrilled and grateful that Dr. Strombeck has chosen to make this crucial information available to all pet lovers. Kudos to him!
Submitted by Mrs. Little | December 28 2013 | Permalink
THANK YOU, Dr. Strombeck for your most helpful information. My dog of 8 yrs is in the early stages of experiencing some kidney failure along with high blood pressure. He's taking medication for the BP. But on this diet you've provided for renal complications in older dogs, it does not indicate if this is a "lifetime" change or if this is just a temporary diet. You do mention the following: "With normal blood levels dietary mineral levels can be modified. It may not be necessary to continue feeding a very low phosphorus diet; doing so may result in deficiency. To increase dietary phosphorus substitute bone meal powder or tablets for calcium carbonate tablets. For example, to one of these diets providing 45 percent of the phosphorus needs, adding bone meal powder in place of 1 1/2 calcium carbonate tablets increases dietary phosphate to meet NRC requirements." So would I substitute the bone meal supplement once a week? I'm understanding it's a "permanent" lifetime change and not temporal. You're the DOC, can you please help? Thank you kindly.
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Placebo Medication North Haven CT
Hamden, CT
Hamden, CT
Hamden Chiropractic Health and Spine Center L
Chiropractic, Auto Accident Care, Workers Comp, Slip and Fall, Family Care, Nutrition, and Muscle Theraphy
Insurance Plans Accepted: Most Plans Accepted
Medicare Accepted: Yes
Workmens Comp Accepted: Yes
Accepts Uninsured Patients: Yes
Emergency Care: Yes
Doctor Information
Medical School: Life University , 01
Additional Information
Languages Spoken: English,Spanish
New Haven, CT
New Haven, CT
Medicare Accepted: No
Workmens Comp Accepted: No
Accepts Uninsured Patients: No
Emergency Care: No
New Haven, CT
Asis Medical Associates
Obstetrics & Gynecology
Hamden, CT
N Branford, CT
New Haven, CT
Asis Medical Associates
Obstetrics & Gynecology
New Haven, CT
Medicare Accepted: No
Workmens Comp Accepted: No
Accepts Uninsured Patients: No
Emergency Care: No
New Haven, CT
Beyond the Sugar Pill
By Stephan Bodian
Every time my friend Emily starts coming down with a cold, she immediately brews up an herbal concoction prescribed for her by a healer in her native New Zealand. Although some medical doctors might argue that no hard-core evidence exists for the therapeutic value of her tea, she usually feels better within a few hours after taking it, and her colds disappear far more quickly than those of anyone else I know.
Another friend, Jason, had reconstructive knee surgery recently and deliberately chose a doctor he trusted not only for his expertise with the scalpel but also for his empathy and communication skills. Jason was out hiking weeks earlier than his prognosis had predicted.
Then there's my friend Linda, who has managed to thrive for five years with metastasized breast cancer. She's undergone conventional treatments like radiation and chemo, but the approach she believes has helped her the most is her daily regiment of meditation, prayer, and inspirational reading.
At first glance, Emily might not seem to have much in common with Jason and Linda. Emily uses alternative remedies exclusively and avoids conventional doctors like the plague, while the other two have embraced mainstream medicine as a significant part of their treatment regime. But a common thread does unite them—they've all benefited from the mysterious phenomenon known as the placebo response.
The Secret of Placebo
Placebos have developed a bad rap over the years as the dummy sugar pills researchers give to the control group in studies to demonstrate the efficacy of the real medication. As a result, the term "placebo" has become synonymous in everyday parlance with harmless but ineffective. The fact is, however, that placebos—although chemically inert—are often just as potent as the drugs to which they're compared. At one point, pharmaceutical companies even tried to suppress the use of placebo-controlled studies because the placebos threatened to upstage the performance of prescription antidepressants.
As it turns out, the placebo response involves far more than just placebo medication—it encompasses a range of mind-body healing effects. The healing modality you choose, the care and concern of your healthcare practitioner, your emotional associations with the medication or intervention you receive, the sounds and sights that greet you in your hospital room or sickbed—any or all of these factors may enhance (or undermine) your healing by eliciting a placebo response.
Howard Brody, MD, coauthor of The Placebo Response: How You can Release the Body's Inner Pharmacy for Better Health (HarperCollins, 2000), has studied the placebo phenomenon for more than 30 years. "Placebo is a change in health caused by the emotional or symbolic effect of the healing context, which includes the actual treatment, the environment, and the actions of others," explains Brody. "Every time a healer administers a treatment or an individual treats herself for an illness, the indivi...
Copyright 1999-2009 Natural Solutions: Vibrant Health, Balanced Living/Alternative Medicine/InnoVisi...


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Instructional Technology Program (Post Master's)
Fran Zilonis
Fran Zilonis
Professor of Practice and Director, School Library Teacher Program
Fran Zilonis brings more than 30 years of experience in school libraries and instructional technology to Simmons SLIS. From 2000-2006, Zilonis was director of information technology for the Newton Public Schools, and from 1994-2000 was full professor and the chair of Secondary Education and Professional Programs (consisting of Counseling, Educational Leadership, High School and Middle School Education, Library Media Studies, and Instructional Technology) at Bridgewater State College. From 1985-1994, she was the director of Educational Media Services for the Cambridge Public Schools, where she obtained and administered one of the first eight DeWitt Wallace-Reader's Digest Fund Library Power grants. Zilonis began her career in the Randolph Public Schools, where she was a library media specialist and subsequently became chairperson of media services K-12. Most recently, she served as the vice principal of academic affairs at Bishop Feehan High School. Zilonis received her M.Ed. in school librarianship from Bridgewater State College in 1973, and her Ed.D. in educational media and technology from Boston University in 1979. In 2005, School Library Journal named her one of the library field's most innovative and influential thinkers. Zilonis joined SLIS as a visiting professor in Fall 2009; she became director of the School Library Teacher Program in July 2010. In July 2012, she became a professor of practice.
Courses Taught
LIS 404: Principles of Management
LIS 406: Management of School Library Programs
LIS 431: Instructional Strategies for the School Library Teacher
Practica Supervision


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|9 Отзывы :
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Life is short; we sometimes forget to fully live it. If your lifestyle
and workload is causing you stress and the fast pace of the modern world
makes you weary, come and stay with us to recharge your personal battery,
feel energized and experience this delightful hideaway in the mountains
of the north of Thailand.
All 60 bungalows were built in the style of Lanna architecture using
local materials. All bungalows have level floors and teak shingles or
earthen tiles are used on the roofs. The bungalows' outer walls are
made of wood while the inner walls are white cement. Wooden furniture
is used to decorate the rooms in order to soften the effects of the
cement walls.
|Standard Room
|Superior Room
|Deluxe Room
Concept : Wake up to a riverside buffet of Thai and intercontinental food at Sala Rim Wang, where you can see the winding currents and the mist of Wang River sparkling in the sun.
Operation hours : 06:00 - 14:00 hrs
Breakfast : 06:00 - 10:00 hrs
Lunch : 11:00 - 14:00 hrs
Seating capacity : 40
Concept : Enjoy dinner at a traditional Thai-Lanna house, encircled by lush rain forest. Buatong restaurant is arranged in style of "Kad Mua" - a local market, where you can walk around and pick your favourite local cuisine.
Operation hours : 18:00 - 22:00 hrs.
Seating capacity : 120
The resort provides 60 bungalows for accommodation, numerous relaxation
corners both indoors and out, a standard swimming pool, a three-rai
wide pond, boat paddling activities and a 4.5 kilometres walk or jogging
path. Cycling is a popular activity with our guests and a cycle in the
village will give you a glimpse of the traditional way of life such
as the small village kiln industry and paddy fields. Wat Prathat Lampang
Luang temple is only 7 kilometres from the resort.
|Hotel Location Map
|Bicycle Trip Map


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York University
Oh, Canada
Why anti-Zionism festers in a country otherwise known for its friendliness
'Exodus: Gods and Kings' is a shoddy imitation of 'Price of Egypt'5:17 PM —
Who needs Christian Bale as Moses when Val Kilmer did a brilliant job in the 90s?
Brooklyn Cantor Leaves Rikers Early3:20 PM —
Baruch Lebovits, who pleaded guilty to child molestation in May, served less than three months
Hitler's Deputy Thought He Was Being Poisoned3:13 PM —
Rudolf Hess' prison food is being photographed for the first time.
'Ghostbusters' for Libertarians1:30 PM —
How the 1984 paranormal comedy ended up in the conservative film canon
'Transparent' is the Most Jewish TV Show in a While—and it's Great12:29 PM —
Jill Soloway's latest offering is absorbing, sincere, and tender
My Husband Wanted to Break the Fast Early and I Didn't11:15 AM —
A case of how doing what seems wrong can also be what's right
Is Baseball's Rod Carew Jewish?10:30 AM —
Setting the record straight on the Hall of Famer's 69th birthday
A Brief History of a Fowl Custom9:50 AM —
Talmudic scholars have never agreed on the pre-Yom Kippur chicken sacrifice
Watch Israeli President Reuven Rivlin's Moving Anti-Racism Message9:13 AM —
Rivlin joins 11-year-old George Amira, whose anti-bullying video went viral
Orthodox Man Refuses To Sit Next to Feminist Activist on AirplaneBy Elana Sztokman — Elana Sztokman flies the not-so friendly skies home to Israel
It's Never Too Late To AtoneBy Etgar Keret — Even if the person you wronged doesn't remember what you did, it can still make a difference to ask for forgiveness. Maybe.
How To Say You're SorryBy Marjorie Ingall — As Yom Kippur approaches, I'll share what I've learned about how to apologize—and how not to
The Most Important Thing Netanyahu Did in New York Wasn't at the U.N.
Facebook, Unchain Me!
My Jewish Feminism: A Memoir
El Al Petition Seeks to End Gender Discrimination
The Truth About Israel and Dissent
How Time's Arrow and the Phrygian Half-Step Make Jewish Music Holy
Twitter: tabletmag
- RT @NinaBadzin: "How to Say Sorry" by @MarjorieIngall is a great Yom Kippur read. Always love her work via @tabletmag http://t.co/RafljfK1Sa
Basya Schechter Mixes Prayer Songs With Brass, Oud, and Radiohead
On a new album, the captivating leader of the band Pharaoh's Daughter reclaims the music that dominated her religious childhood
Love Syndrome: Israel Story, Episode 2
Chaya Ben Baruch's sixth child was born with Down syndrome. Then she did what every good mother does—set out to find him a mate.
Leonard Bernstein: A New Look at His Rise, His Foibles, and His Impact on Music History
The dynamic conductor and genius behind 'West Side Story' also wrote classical works. Allen Shawn explores what they reveal.
- Debut Novelist Yelena Akhtiorskaya on Misery, Writing, and Brighton Beach
- Review: "This Is Where I Leave You"
- Buzzfeed Hipsters Sample Jewish Food For the First Time
- Brooklyn's Best Vintage Store Also Supports Jewish Kids With Serious Illnesses
- Playwright Jessica Goldberg?s ?Better?: When misery begets art
- My Evening with LeAnn Rimes & the LA County Sherriff
- A Conversation with Jim Marchese of Real Housewives of New Jersey
- Edge of Tomorrow: At 91, Grandma reflects on the state of the world and her soul for Rosh Hashanah


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Welcome to Samy's Camera Photo Camp
Samy's Camera Photo Camp is a fun, hands-on after school enrichment class that gives the students an overview of different fields of photography, including macro photography, and photojournalism. Students are taught the basics of perspective, framing, and composition. Students are able to engage in a full hands-on photo taking experience.
Samy's Camera Photo Camp began in 2009 as a great idea by Mike Wood—a way to promote Samy's Camera as a positive influence in the community, and bring photography education to Los Angeles schools where arts programs have fallen prey to budget cuts.
With Samy's approval and support, Mike teamed up with Deborah Cloyed and Samy's Camera Photo Camp was born.
Two and half years later, the program is a huge success! Photo Camp has taught over THREE HUNDRED students at NINE different elementary schools across the Los Angeles area, from Eagle Rock to Marina del Rey.
There are three 8 or 9-week semesters of Photo Camp a year. We teach at each school, one day a week, allowing for up to five schools each semester.
Samy's Camera Photo Camp has been such a blessing, in addition to being such a feel-good success with the parents, teachers, and local leaders of Los Angeles. The reach of this program is mind-boggling. We are infinitely proud of our students and love watching them grow and evolve each time. We are inspired by the unique and creative way kids look at the world and amazed at the complicated concepts (composition, lighting, perspective, framing, tone, and much more) they master.
We truly believe what we tell our students—that photography can and does change the world. Photography enriches our individual lives, while holding the power to transform world perception and history. Photography alone can record slivers of time while allowing the artist to mold the meaning and emotion his/her photo conveys. What better way to share our singular love and knowledge of the art of photography here at Samy's Camera, than by educating and inspiring the next generation of photographers?!


text: Office provides simple and cost-effective solutions for multilingual individuals, families, and small businesses. Simply select a language in the list below to learn what option is available to you. Additional languages will become available in the future, so check this page again soon if you don't see the language you want now.


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- Flat Rate Shipping. Any Size Order! -
- A Portion of Proceeds Benefit Baltimore Ravens Athletics -
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It's never too early to teach your little lady how to dress for the Ravens! This two-pack of pink onesies will get your itty bitty girl ready for the Baltimore football games. The long sleeve creeper features a distressed team name, logo and pink hearts printed on the chest and a sewn-on team label at the left wrist, so everyone will know who her heart belongs to. The short sleeve creeper reads "I'm cute and a Ravens fan. Gotta love me!" accented by pink flowers on the chest and another team label sewn on the left sleeve, making her quite the attraction at any Baltimore event. Also featuring scalloped trim along the necklines and ruffle details at the cuffs, these one-pieces will give your teeny tiny chicka a fabulous look to flaunt in the stands!
- 100% Cotton fabric
- Imported
- Lap shoulder necklines
- Officially licensed NFL product
- Screen print graphics
- Three snaps at bottoms
- Woven labels
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Customized items can be personalized with options such as your name, your favorite number, and/or designs. Some options may be limited by league rules.