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BSA Approves Nanotechnology Initiative
On July 12, the National Cancer Institute's (NCI's) Board of Scientific Advisors (BSA) approved by unanimous vote the NCI Alliance for Nanotechnology in Cancer concept, a $145 million, 5-year initiative that will explore the potential for integrating nanotechnology platforms into cancer research. The Alliance, including researchers, clinicians, and public and private organizations, will build on existing scientific knowledge and accomplishments to help find ways to apply nanotechnology to cancer prevention, detection, diagnosis, and treatment.
"This new cancer initiative comes at a critical time, given the scientific advances in genomics, proteomics, and molecular imaging; our increased understanding of the mechanisms of cancer; and the rapidly expanding information technology capabilities for handling vast amounts of data," said NCI Director Dr. Andrew C. von Eschenbach. "The NCI Alliance has the potential to be transformational as we work together across all scientific disciplines to develop new preventive, diagnostic, and therapeutic applications." Read more
SPOREs: A Force in Translational Research
One of the central components of NCI's efforts to move new interventions to patients more quickly is the Specialized Programs of Research Excellence (SPOREs). The SPOREs program is a true success story. When the program was launched in 1992, there were 8 SPOREs for 3 cancer sites; there are now 61 SPOREs for 14 cancer sites. In 1995, there were 3 SPORE-operated clinical trials; in 2004, there are 120.
The 12th SPOREs Investigators' Workshop closed today in Baltimore; it demonstrated that SPOREs have become models of collaboration. Nearly every SPORE is part of an inter-SPORE network that is jointly conducting research and clinical trials. The six lung cancer SPOREs, working with some industry groups, for example, are conducting trials investigating EFGR inhibitors and novel Hedgehog pathway inhibitors. The 10 breast cancer SPOREs are working with the American College of Radiology Imaging Network and the Cancer and Leukemia Group B on a phase III, multicenter breast cancer therapy trial using advanced technologies like MRI and genomic and proteomic analyses to develop molecular characterizations of breast cancer tumors and measure tumor response to neoadjuvant therapy. Read more
BSA Approves Nanotechnology Initiative
On July 12, the National Cancer Institute's (NCI's) Board of Scientific Advisors (BSA) approved by unanimous vote the NCI Alliance for Nanotechnology in Cancer concept, a $145 million, 5-year initiative that will explore the potential for integrating nanotechnology platforms into cancer research. The Alliance, including researchers, clinicians, and public and private organizations, will build on existing scientific knowledge and accomplishments to help find ways to apply nanotechnology to cancer prevention, detection, diagnosis, and treatment.
"This new cancer initiative comes at a critical time, given the scientific advances in genomics, proteomics, and molecular imaging; our increased understanding of the mechanisms of cancer; and the rapidly expanding information technology capabilities for handling vast amounts of data," said NCI Director Dr. Andrew C. von Eschenbach. "The NCI Alliance has the potential to be transformational as we work together across all scientific disciplines to develop new preventive, diagnostic, and therapeutic applications."
At its June 24 meeting, the BSA heard about the proposed initiatives for the Alliance. The July 12 follow-up meeting included presentations by researchers, clinicians, and engineers currently engaged in nanotechnology research. Based on feedback from the Board, Dr. Gregory J. Downing, director of NCI's Office of Technology and Industrial Relations, presented a revised concept reflecting BSA input. Specifically, the Board recommended the development of a steering committee, focused training programs for translational research, and emphasized the importance of cancer biology in the development of new technology platforms. The Board also recommended that the Alliance develop ways to involve patient organizations as it goes forward.
"We are grateful to the Board for its critical thinking that has much improved this effort. They have helped us shape our plan and refocus the way in which we are going to achieve our goal of advancing the integration of nanotechnology into cancer research," said Dr. von Eschenbach.
"We are very pleased with the BSA's decision because we are confident that nanotechnology will generate breakthrough advances in the field of cancer research," said Dr. Mauro Ferrari, professor at Ohio State University and special expert in nanotechnology to NCI. "Nanotechnology will not displace other modes of cancer research, but will instead offer new tools to researchers and clinicians.
"NCI has been a leader in funding cancer-related nanotechnology research for the past 5 years. Multiple strategies have been adopted to support efforts that will ensure a comprehensive and strategic cancer nanotechnology research portfolio, including NCI-supported cancer nanotechnology symposia, coordinated research efforts between intramural and extramural research, and implementation of NCI's Cancer Nanotechnology Plan (CNPlan).
The CNPlan includes integrated, milestone-driven, and product-oriented projects, including Centers of Cancer Nanotechnology Excellence, multidisciplinary research teams, and nanotechnology platforms for cancer research.
NCI has devoted the past year to soliciting input and feedback on the CNPlan from a large cross-section of the cancer community. "This effort is about creating translational research teams of the future," said NCI deputy director Dr. Anna Barker. "The Plan will only succeed with widespread participation from multiple scientific disciplines and partners."
For more information, visit: http://otir.cancer.gov.
SPOREs: A Force in Translational Research
One of the central components of NCI's efforts to move new interventions to patients more quickly is the Specialized Programs of Research Excellence (SPOREs). The SPOREs program is a true success story. When the program was launched in 1992, there were 8 SPOREs for 3 cancer sites; there are now 61 SPOREs for 14 cancer sites. In 1995, there were 3 SPORE-operated clinical trials; in 2004, there are 120.
The 12th SPOREs Investigators' Workshop closed today in Baltimore; it demonstrated that SPOREs have become models of collaboration. Nearly every SPORE is part of an inter-SPORE network that is jointly conducting research and clinical trials. The six lung cancer SPOREs, working with some industry groups, for example, are conducting trials investigating EFGR inhibitors and novel Hedgehog pathway inhibitors. The 10 breast cancer SPOREs are working with the American College of Radiology Imaging Network and the Cancer and Leukemia Group B on a phase III, multicenter breast cancer therapy trial using advanced technologies like MRI and genomic and proteomic analyses to develop molecular characterizations of breast cancer tumors and measure tumor response to neoadjuvant therapy.
The SPOREs program also recently completed work on another groundbreaking activity. Two SPORE-member workgroups reviewed the research pipeline for two fertile areas of translational research: molecular targets and biomarkers. This review allowed NCI leaders to assess the status of the research in these two areas and will help us identify the best opportunities for advancing the most promising biomarkers and molecular targets.In another sign of SPOREs' impressive evolution, 70 patient advocates attended this year's workshop as part of an innovative SPOREs initiative, the Patient Advocate/Research Team (PART) program, which has helped build a bridge between SPOREs researchers and patients. In many cases, PART participants go well beyond the traditional patient advocacy role, involving themselves in SPOREs' operational aspects by reviewing small seed grants that SPOREs may wish to fund or facilitating discussions between SPOREs and national organizations or industry on possible collaborations.
"The SPOREs' principal investigators are serious about bringing advocates into the program," says Jim Williams, a 13-year prostate cancer survivor, board member of the Intercultural Cancer Council, and a member of the PART at the Baylor University prostate cancer SPORE. "We can really bring the patient's viewpoint to the trials." Advocates like Jim are to be commended for their commitment to improving cancer care for all patients.
I also came away from the SPOREs workshop with an important reaffirmation of one of my most sincere beliefs: The intellectual capital of the research force we have assembled is unsurpassed in the history of cancer research. There are, of course, still challenges that must be addressed, from intellectual property to regulatory issues. But these are surmountable challenges that we are working to address. In the end, though, with programs like SPOREs, it is clear to me that we are on an ideal trajectory for success, allowing for exponential progress during a time of great promise and hope.
Dr. Andrew C. von Eschenbach
SELECT Recruits African Americans
The final enrollment figures for the Selenium and Vitamin E Cancer Prevention Trial (SELECT), the largest-ever prostate cancer prevention trial, boast 35,534 participants - more than 3,000 above the accrual goal. As reported in the April 20 NCI Cancer Bulletin, enrollment for SELECT - funded by NCI and coordinated by the Southwest Oncology Group - was closed to accrual about 2 years ahead of schedule.
Approximately 15 percent of SELECT participants are African American. "That is a significant accomplishment," said Dr. Lori Minasian, chief of the Community Oncology and Prevention Trials Research Group in the NCI Division of Cancer Prevention. Because African American men frequently develop prostate cancer at an early age, their eligibility age for the study was dropped from 55 to 50. And in fact, one-third of African American SELECT participants are between 50 and 55. "Opening accrual to younger African American men was a key element in recruiting so many participants from this population," Dr. Minasian said.
Both general and targeted recruitment mechanisms proved effective. For one national event, called "SELECT Sunday," SELECT sites worked with predominantly black churches across the country to educate their parish-ioners about prostate cancer and how to enroll in SELECT. Trial leaders also took advantage of local and national media. "It was heartening that so many men volunteered to participate in this study," remarked Dr. Minasian.
COX-2 Inhibitor Studied in Pancreatic Cancer
Patients with advanced pancreatic cancer may receive some benefit with minimal toxicity from a combination regimen that includes a COX-2 inhibitor, according to the results of a small pilot study by Italian researchers. In the study, published in the July 1 Cancer, 17 patients with progressive advanced pancreatic ductal adenocarcinoma (PDAC), who had received gemcitabine-based chemotherapy, were given continuous treatment with the COX-2 inhibitor celecoxib (Celebrex) and protracted intravenous 5-fluorouracil (5-FU). Of the 16 patients for whom there were results that could be evaluated, 2 had partial responses (23 and 68 weeks, respectively) and 2 had stable disease (10 weeks and 13 weeks, respectively). The overall response rate was 12 percent. Median time to disease progression was 8 weeks and median overall survival was 15 weeks.
PDAC has proven to be resistant to chemotherapy, lead author Dr. Michele Millela of the Regina Elena National Cancer Institute in Rome, wrote. Whereas bolus administration of 5-FU in patients with metastatic, advanced pancreatic cancer has shown to be relatively inactive, continuous 5-FU combined with COX-2 inhibition appears to be "feasible and demonstrates encouraging preliminary activity even in a population of chemotherapy- pretreated patients with far-advanced PDAC." In the study, they noted, "treatment-related toxicity was minimal and manageable, making this combination very attractive in an essentially palliative setting."
PSA Velocity and Prostate Cancer Treatment Outcome
PSA velocity - the rate at which prostate-specific antigen (PSA) levels rise - has a direct relationship to mortality from the disease, according to a study published in the July 8 New England Journal of Medicine. The prospective study by researchers at Harvard Medical School, the University of Connecticut, and Washington University School of Medicine in St. Louis followed 1,095 men for a median of 5.1 years and focused on whether men at risk for death from prostate cancer after radical prostatectomy can be identified using information available during the year before diagnosis.
Measuring PSA blood levels is the current standard for monitoring a man's status/risk of prostate cancer. A cutoff point is used to determine whether further screening is necessary; levels between 0 and 4 are considered normal while levels 20 and higher are considered extremely elevated. "The vast majority of men with prostate cancer present with a nonpalpable tumor and come to medical attention because of an elevated or rising level of PSA," the study authors report.
Men followed in this study who had annual PSA velocities greater than 2.0 nanograms per milliliter (ng/ml) had a higher risk of death from prostate cancer than those with scores of 2.0 ng/ml or less. The scientists also found that initial PSA velocities greater than 2.0 ng/ml remained significantly associated with prostate cancer mortality regardless of pathological reports from prostatectomies. However, they caution that although PSA velocity is linked with prostate cancer death, the initial Gleason score, clinical tumor stage, and PSA level must also still be considered important risk factors.
Late Cardiac Effects in Childhood Cancer Survivors
Use of the free-radical scavenger dexrazoxane (Zinecard) may protect children with acute lymphoblastic leukemia (ALL) from cardiac damage associated with doxorubicin (Adriamycin), University of Miami researchers reported in the July 8 New England Journal of Medicine. Doxorubicin is a component of highly effective treatments for children with ALL, the most common malignancy in children. However, it has also been associated with late cardiac effects, including congestive heart failure, as well an increased risk of death from cardiac causes.
In the study, 206 children newly diagnosed with high-risk ALL were randomized to treatment with only the standard multiagent protocol for ALL, which includes doxorubicin, or to standard treatment plus an infusion of dexrazoxane 30 minutes before receiving doxorubicin. Patients' troponin T blood levels - a sensitive and specific biomarker for cardiac injury - were measured at the time of diagnosis and at various points until the end of therapy. While 50 percent of the children in the chemotherapy-only arm of the study had elevated troponin T levels, only 21 percent of the children who received dexrazoxane showed an increase. Dexrazoxane appeared to have no impact on the chemotherapy's short-term effectiveness.
Long-term follow-up on dexrazoxane's effects is still needed, cautioned Dr. Malcolm Smith, associate branch chief for pediatrics in NCI's Cancer Therapy Evaluation Program and Dr. Noreen Aziz, program director in NCI's Office of Cancer Survivorship. "Additional data are needed to demonstrate that dexrazoxane has no effect on the antileukemia activity of doxorubicin and can be used in the treatment of children with ALL without fear of compromising their overall survival," Dr. Smith said. Long-term follow-up and a recently completed NCI-sponsored trial that evaluated dexrazoxane in more than 500 children with T-cell ALL, he added, should help determine dexrazoxane's optimal role.
HPV May Play Role in Head and Neck Cancer
Head and neck squamous cell carcinomas (HNSCCs) that harbor human papillomaviruses (HPV) have a different pattern of genetic changes than tumors without HPV. These patterns suggest that HPV may play a role in the development of HNSCC, according to Dr. Boudewijn Braakhuis and colleagues at the VU University Medical Center in Amsterdam in the July 7 Journal of the National Cancer Institute.
Previous studies have suggested that HPV may play a role in the development of HNSCCs, and HPV DNA has been detected in the tumors of 10-20 percent of HNSCC patients. To find a possible mechanism by which HPV might cause HNSCC, researchers looked at HPV DNA and RNA and genetic alterations in the tumors of 143 HNSCC patients. HNSCCs with transcriptionally active and inactive HPV DNA had different genetic patterns that support the idea that HNSCCs can be subdivided into two distinct categories and that HPV infection is involved in the early development of some HNSCCs. "Our results are consistent with the hypothesis that HNSCCs develop by two different etiologies: one driven by exposure to environmental carcinogens (e.g., tobacco and alcohol) without HPV involvement and the other involving infection with transcriptionally active [HPV]," the authors wrote.
In an editorial, researchers from the University of Texas M. D. Anderson Cancer Center noted that "understanding how the [HPV] viral proteins interact with cellular proteins and/or DNA in host cells may allow us to design strategies to block malignant transformation."
Carcinogenic Food Ingredient Studied
Researchers have discovered a possible mechanism by which acrylamide - a chemical by-product of processing common foods, such as breakfast cereals and french fries - causes cancer in mice. They also found a similar mutagenic mechanism at work in human bronchial tissue exposed to the chemical and its metabolite, glycidamide.
In a study in the July 7 Journal of the National Cancer Institute, Dr. Ahmad Besaratinia and his colleagues at the City of Hope National Medical Center in Duarte, Calif., reported on the effects of acrylamide and glycidamide on specific genes in mouse cells and in human bronchial epithelial cells. They found that acrylamide and glycidamide, in particular, bind to the DNA, forming adducts at similar specific locations in each of the genes studied. These DNA adducts, which were more common when the cells were treated with glycidamide, coincided with the locations of specific gene mutations in both the mouse and human cell models.
The authors report, "…glycidamide is largely responsible for the mutagenicity of acrylamide." The doses used in the study "might seem too high to be achieved by human dietary exposure alone," they acknowledged. "However, the ever-presence of human exposure to acrylamide on a daily basis makes these estimates somehow more tangible if not achievable. From a public health standpoint, these findings reiterate the need for reconsidering the presence of acrylamide in the human diet and the environment."
Central Review Board Will Speed Implementation of Pediatric Clinical Trials
The PedCIRB is an expansion of the NCI Central IRB (CIRB) Initiative, begun in 2001, for simplifying the review of Institute-sponsored Cooperative Group treatment studies. The CIRB provides an innovative approach to human subject protection for adults through a "facilitated review" process, which aims to streamline local IRB reviews of national multicenter cancer treatment trials.
"The PedCIRB will ease the administrative burden on institutions that participate in clinical studies involving children and adolescents," said Dr. Barry Anderson of NCI's Cancer Therapy Evaluation Program (CTEP). The PedCIRB will act as the clearing IRB for pilot, phase 2, and phase 3 clinical trials conducted by the Children's Oncology Group (COG). COG currently enrolls approximately 4,000 children and adolescents in treatment studies annually and has 70-80 studies open to patient accrual each year. "Local IRBs at the 238 institutions that comprise COG will decide individually about affiliating with the PedCIRB. Those institutions that join can decide on a case-by-case basis whether to approve the study using the PedCIRB review or to conduct their own assessment of the protocol," said Dr. Vita J. Land, executive director of the PedCIRB.
Every cancer study and its patient consent form must be approved by an IRB that includes physicians, ethicists, patient advocates, and others who help to ensure that any trial that cancer patients enter is ethical, informs them of potential risks, and maintains their confidentiality. A local IRB's consideration of a study can take weeks and involves a large investment of professional and volunteer time. Since most studies sponsored by NCI are conducted at multiple institutions, the same protocol is reviewed by each of the multiple local IRBs.
Jacquelyn Goldberg, who directs the overall initiative for NCI, commented, "The PedCIRB, similar to the adult Board, should reduce the necessity for duplicate reviews." Local IRBs must still ensure, through an abbreviated approval procedure, that the investigators and other staff at the local institution are appropriately qualified. Local IRBs will still monitor protocol compliance. The composition of the central IRBs is similar to that required for local IRBs, except that it has the unique advantage of being able to draw on pediatric oncology expertise from across the whole country.
The 17-person PedCIRB includes 10 physicians with pediatric subspecialty expertise, 2 nurses, 1 bioethicist, 4 patient advocates, 1 pharmacist, and 1 statistician. This diverse membership will ensure that the PedCIRB provides broad clinical and ethical expertise for the review of COG treatment protocols. In view of the special considerations required for the evaluation of research involving children, the board members' extensive experience reviewing pediatric clinical trials is a valuable asset to the PedCIRB.
Easing the difficulties local IRBs face in meeting administrative and regulatory demands should facilitate swifter and more efficient trial start-up and completion. Enhancing the development and delivery of improved therapeutics for pediatric cancer patients will prove crucial to meeting the challenge goal of eliminating the suffering and death due to cancer by 2015. The PedCIRB plans to review its first COG protocols in November.
Combination Biological and Chemotherapy for Advanced Pancreatic Cancer
Name of the Trial
Principal Investigator
Why Is This Trial Important?
The chemotherapy drug gemcitabine (Gemzar) is a commonly used treatment for advanced pancreatic cancer, but its benefits are minimal. Researchers hope that adding cetuximab (Erbitux), a monoclonal antibody, to gemcitabine will result in an improved response.
Early clinical work with cetuximab has shown that it does have some effectiveness against pancreatic cancer. Cetuximab binds to cancer cells and blocks a protein called epidermal growth factor receptor (EGFR). EGFR is found in abnormally high amounts on the surface of many types of cancer cells, causing the cells to divide excessively in the presence of epidermal growth factor proteins.
"Currently there is no satisfactory treatment for pancreatic cancer," said Dr. Philip. "This trial employs a novel targeted therapy that blocks EGFR, hopefully resulting in cancer cells that are less likely to proliferate, more sensitive to chemotherapy, and more prone to apoptosis, or cell death."
Who Can Join This Trial?
Where Is This Trial Taking Place?
Who to Contact
An archive of "Featured Clinical Trial" columns is available at http://cancer.gov/clinicaltrials/ft-all-featured-trials.
Understanding Mechanisms of Health Risk Behavior Change in Children and Adolescents
NCI invites research grant applications that will enhance our understanding of the factors and mechanisms that determine changes in health risk behaviors during childhood and adolescence. The concept of health risk behavior change is used in this PA to encompass the evolution of specific health-impairing behaviors. Of particular interest are factors and processes that influence the initiation, continuation, and/or cessation of one or more of the following health risk behaviors: 1) Substance abuse, 2) inadequate exercise and poor dietary practices as they relate to being overweight or obese, and 3) intentional and unintentional injuries.
The PA will use the R01 and R21 award mechanisms.
For more information see http://cri.nci.nih.gov/4abst.cfm?initiativeparfa_id=2160. Inquiries: Dr. Louise C. Mâsse, email@example.com
Studies of Energy Balance and Cancer in Humans
NCI invites investigator-initiated research applications on the relationships between energy balance, cancer risk, and prognosis energy balance in humans. These studies will focus on research to define factors affecting energy balance and to define mechanisms influencing cancer risk, prognosis, and quality of life. These studies may range from new analyses of existing datasets to additional collection of data and biological specimens in ongoing investigations. Applicants must have previously collected measures from human subjects on two or more of the following exposures: diet, physical activity, body composition, and/or related biomarkers (such as blood, urine, exfoliated cells, and/or tissue samples).
This PA will use the NIH Investigator-Initiated Research Project Grants (R01), NIH Exploratory/Developmental Grants (R21), and Competitive Supplements to existing NCI-funded grants.
For more information see http://cri.nci.nih.gov/4abst.cfm?initiativeparfa_id=2163. Inquiries: Dr. Virginia W. Hartmuller, email@example.com; Dr. Noreen M. Aziz, email@example.com; Dr. Jackie Whitted, firstname.lastname@example.com
Novel Approaches to Enhance Animal Stem Cell Research
The purpose of this PA is to encourage the submission of applications for research to enhance animal stem cells as model biological systems. Innovative approaches to isolate, characterize, and identify totipotent and multipotent stem cells from nonhuman biomedical research animal models, as well as to generate reagents and techniques to characterize and separate those stem cells from other cell types, is encouraged. Studies involving human subjects are not allowed under this PA. This PA supersedes PA-02-147 issued earlier by the National Center for Research Resources.
The PA will use the NIH R01 and R21 award mechanisms.
For more information see http://cri.nci.nih.gov/4abst.cfm?initiativeparfa_id=2162. Inquiries: Dr. Donald Blair, firstname.lastname@example.com
International Team to Evaluate Traditional Chinese Medicine for Cancer
NCI's Office of Cancer Complementary and Alternative Medicine (OCCAM) is supporting the development of an international center that partners the University of Texas M.D. Anderson Cancer Center in Houston with the Cancer Hospital, Fudan University in Shanghai, China. The grant is the first step in developing a center to study the use of traditional Chinese medicine for cancer treatment and symptom management. The research teams will investigate herbal and natural product treatments that target the disease and disease-related symptoms and outcomes, the effectiveness of acupuncture on specific symptoms in cancer patients, and the biobehavioral effects of qigong and other mind/body-based therapies in cancer patients. This is the first NCI grant to support such an international partnership to study an alternative medical system. For more information about OCCAM, go to: http://cancer.gov/cam.
Winn Leads NCI's Genetic Epidemiology Research Branch
Dr. Deborah Winn has been appointed chief of the NCI Epidemiology and Genetics Research Program's (EGRP) Clinical and Genetic Epidemiology Research Branch (CGERB). Dr. Winn had been CGERB's acting chief and was senior epidemiologist for tobacco and cancer control in EGRP. She also served at one time as acting associate director of EGRP. Dr. Winn has been instrumental in guiding the EGRP-funded Cancer Genetics Network and has been very involved in helping CGERB develop initiatives in gene-gene and gene-environment interactions. She is known nationally and internationally for her work and writings on smokeless tobacco and the etiology of oral cancer. She is NCI program coordinator for the Long Island Breast Cancer Study Project, and has been a key member of the Health Disparities Research Coordinating Committee in the Division of Cancer Control and Population Sciences, of which EGRP is a part.
Dr. Sheue-yann Cheng Receives Mentor Award
Dr. Sheue-yann Cheng in the Laboratory of Molecular Biology in NCI's Center for Cancer Research is this year's recipient of the Abbott Thyroid Research Clinical Fellowship Mentor Award from the Endocrine Society. Abstracts on the molecular genetics of thyroid carcinoma by two of her fellows, Drs. Caroline Kim and Yasuhito Kato, were selected from hundreds of submissions to compete at the oral presentation for the mentor award. Dr. Kim won the competition. The mentor award was presented to Dr. Cheng at the June 18 plenary session of the annual meeting of the Endocrine Society. The award provides $30,000 for unrestricted use for Dr. Cheng's research.
This is a list of selected scientific meetings sponsored by NCI and other organizations. For locations and times and a more complete list of scientific meetings, including NCI's weekly seminars and presentations open to the public, see the NCI Calendar of Scientific Meetings at http://calendar.cancer.gov.
NCI Exhibits


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Newsweek Inc. (The Daily Beast)
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News about Newsweek Inc. (The Daily Beast), including commentary and archival articles published in The New York Times.
Chronology of Coverage
Mar. 18, 2014
California engineer Dorian Nakamoto appears to be laying the groundwork for a lawsuit against Newsweek after the magazine identified him as the mysterious creator of Bitcoin; unconditionally denies having any involvement with the digital currency and says Newsweek's article has harmed him. MORE
Mar. 8, 2014
Newsweek's return to newsstands, after being out of print for 14 months, features explosive claim that it had uncovered mysterious founder of digital currency Bitcoin; story draws wave of attention, much of it negative, as Dorian Satoshi Nakamoto, reclusive train collector from California and man Newsweek identifies as Bitcoin's founder, gives two-hour interview to The Associated Press saying story is wrong. MORE
Mar. 6, 2014
An article about a man in Southern California named Satoshi Nakamoto has prompted many enthusiasts to question whether the right person had been identified as the creator of the virtual currency Bitcoin. MORE
Mar. 3, 2014
IBT Media is posed to resume the printing of Newsweek and place magazine back on newsstands; IBT, which purchased struggling newsweekly for pittance, sees potential path of growth where giants of publishing have failed. MORE
Dec. 4, 2013
Newsweek, which has been sold twice in the last three years and ceased print publication in 2012, expects to begin 64-page weekly edition in January or February. MORE
Aug. 11, 2013
Sales of three giants of the old-media world--The Washington Post, The Boston Globe and Newsweek--were at prices a fraction of the properties' former value; Tumblr's $1.1 billion sale suggests market believes that its model is way of the future. MORE
Aug. 5, 2013
Tina Brown reflects on ill-fated merger of The Daily Beast and Newsweek, following two and a half years of lost opportunity and revenue. MORE
Aug. 4, 2013
Newsweek is bought by International Business Times for undisclosed amount, three years after billionaire investor Sidney Harman purchased weekly magazine from The Washington Post and merged it with The Daily Beast. MORE
May. 3, 2013
Longtime media critic Howard Kurtz will resign as Washington bureau chief of The Daily Beast and Newsweek; announcement comes as Kurtz is embroiled in controversy over blog post concerning basketball player Jason Collins. MORE
Sep. 2, 2012
Anne Eisenberg Off the Shelf column highlights book The Good Girls Revolt by Lynn Povich, about how a small band of women at Newsweek successfully challenged sex discrimination at the magazine and throughout the industry in the late 1960s and early 1970s. MORE
Aug. 13, 2012
David Carr The Media Equation column observes that making a weekly newsmagazine has always been tough, but the problem is that magazines do not work very well in the marketplace anymore; highlights further drop in sales and advertising revenue, especially for Newsweek, and holds that Americans seem more interested in reading content on their phones than in a traditional magazine. MORE
Jun. 4, 2012
Michael Winerip On Education column contends that high school rankings published by Newsweek and other organizations strongly favor elite, selective schools in wealthy communities; argues that lists overlook schools that truly improve the lives of underprivileged students. MORE
Feb. 13, 2012
Spate of vulgarity printed in Newsweek following its merger with the Daily Beast could cost the the news-magazine a valuable partner in the public television stations that offer the magazine as a donation gift. MORE
Nov. 15, 2011
Newsweek is jolted by three high-level departures in a sign that year-old merger with The Daily Beast has left the magazine deeply unsettled; editing and reporting ranks are straining under Tina Brown's high-pressure management style; among those leaving is executive editor Edward Felsenthal. MORE
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What We're Reading
Recommended reads from New York Times reporters and editors, highlighting great stories from around the web.
August 8, 2014, Friday
MORE ON NEWSWEEK INC. AND: Kantor, Jodi , Smith, Dave , Israel , Newsweek , Wall Street Journal , Washington Post , Baseball , Defense and Military Forces , Music , Newspapers
A Novel Lays Bare Media Ills
At first glance, "The Last Magazine: A Novel" by Michael Hastings would appear to lack relevance in the current media age, but even from the grave Mr. Hastings has demonstrated anew an ability to reframe the debate.
June 23, 2014, Monday
MORE ON NEWSWEEK INC. AND: News and News Media , The Last Magazine (Book) , Iraq War (2003-11) , Magazines , Newsweek , Hastings, Michael , Books and Literature
Far From Beijing, Jaded Students Inspired to Protest
The Tiananmen protests of 25 years ago are well documented, but less well known are the protests took place across China, paralyzing cities large and small for nearly two months that spring.
June 3, 2014, Tuesday
MORE ON NEWSWEEK INC. AND: Hu Yaobang , Lim, Louisa , Mao Zedong , Guangzhou (China) , China , Chengdu (China) , Tiananmen Square (Beijing) , Hubei Province (China) , Heilongjiang Province (China) , Harbin (China) , Beijing (China) , Voice of America , Communist Party of China , Newsweek , People (Magazine) , British Broadcasting Corp , Demonstrations, Protests, and Riots
Putative Bitcoin Founder Categorically Denies It
Dorian Nakamoto appeared to be laying the groundwork for a lawsuit against Newsweek, saying its article had harmed him. He stopped short of saying he would sue.
March 18, 2014, Tuesday
MORE ON NEWSWEEK INC. AND: Bitcoin (Currency) , Suits and Litigation (Civil) , Newsweek , Nakamoto, Dorian Satoshi
Will the Real Satoshi Nakamoto Please Stand Up?
Particularly in Japan, those named Satoshi Nakamoto have been garnering a lot of attention as the search continues for the creator of Bitcoin.
March 11, 2014, Tuesday
MORE ON NEWSWEEK INC. AND: Mochizuki, Shinichi , Nakamoto, Dorian Satoshi , Nakamoto, Satoshi , Japan , Newsweek , Names, Personal , Bitcoin (Currency)
Newsweek Returns to Print and Sets Off a Bitcoin Storm
The magazine's story claiming to have uncovered the founder of the digital currency drew a wave of attention, much of it negative.
March 8, 2014, Saturday
MORE ON NEWSWEEK INC. AND: Magazines , Bitcoin (Currency) , Nakamoto, Satoshi , Impoco, Jim , Goodman, Leah McGrath , Newsweek , Nakamoto, Dorian Satoshi
Daily Report: Mystery Swirls Around Unmasking of Bitcoin Inventor
A Newsweek article contends that a man in Southern California named Satoshi Nakamoto was the creator of the virtual currency Bitcoin, but many people say they are unconvinced.
March 7, 2014, Friday
MORE ON NEWSWEEK INC. AND: Nakamoto, Satoshi , Newsweek , Bitcoin (Currency)
Bitcoin's Mysterious Creator Is Said to Be Identified
An article about a man in Southern California named Satoshi Nakamoto has prompted many enthusiasts to question whether the right person had been identified as the creator of the virtual currency Bitcoin.
March 6, 2014, Thursday
MORE ON NEWSWEEK INC. AND: Newsweek , Bitcoin (Currency) , Nakamoto, Dorian Satoshi , Nakamoto, Satoshi , California
Tiny Digital Publisher to Put Newsweek Back in Print
IBT Media, a small digital publishing company that bought Newsweek for a pittance last summer, is poised to place the magazine on newsstands again this Friday.
March 3, 2014, Monday
MORE ON NEWSWEEK INC. AND: Impoco, Jim , Newsweek , IBT Media , Uzac, Etienne , Magazines , Davis, Jonathan (1982- )
Douglas Davis, Newsweek Critic and Internet Artist, Dies at 80
Mr. Davis was a critic, an author and an artist, whose work explored the possibilities of video and the Internet as creative and interactive mediums.
January 23, 2014, Thursday
MORE ON NEWSWEEK INC. AND: Davis, Douglas (1933-2014) , Deaths (Obituaries) , Art , Computers and the Internet , Newsweek
Bitcoin's Purported Founder Speaks Out
Newsweek reported that Dorian Satoshi Nakamoto was the founder of the digital currency Bitcoin. But Mr. Nakamoto denied the claim in an exclusive interview with The Associated Press.
Bitcoin's Purported Founder Speaks Out
Newsweek reported that Dorian Satoshi Nakamoto was the founder of the digital currency Bitcoin. But Mr. Nakamoto denied the claim in an exclusive interview with The Associated Press.
What's the Going Price?
The sales of three giants of the old-media world — the Washington Post, The Boston Globe and Newsweek — in as many days suggest one kind of change, but their prices suggest another.
The Week in Business Photos, Oct. 19
Storm clouds continued to grow over Europe's debt crisis, Vikram S. Pandit stepped down as chief of Citigroup, and Newsweek announced that it would stop printing its magazine at the end of the year.
Newsweek to Adopt a Digital-Only Format
Business Day Live: Christine Haughney reports on Newsweek's announcement that it will cease print publication at the end of the year.
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subset: commoncrawl


text: "And whenever you fast, do not put on a gloomy face as the hypocrites do, for they neglect their appearance in order to be seen fasting by men. Truly I say to you, they have their reward in full. But you, when you fast, anoint your head, and wash your face so that you may not be seen fasting by men, but by your Father who is in secret; and your Father who sees in secret will repay you." Matthew 6:16-18 NASBSubscribe to Read!


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Steam Big Picture Mode to start public beta today
Valve had told us it was coming in early September, but now we supposedly have a date for the public beta of Steam's Big Picture Mode, where players will be able to click a button to have Steam reformatted for the big screen in their living room. Watch for it sometime this afternoon.
Over the weekend, the New York Times revealed the beta launch in a behind closed doors report on Valve, saying the testing on the new mode would begin "on Monday."
Kotaku, however, offered a more in-depth report, saying that all of Steam's fonts, icons and menus are designed to be viewed comfortably in the living room. Greg Coomer, who headed the team at Valve that developed the new mode, said "We're confident in some things that customers want. They want a full-screen experience. They want to be in the living room. They want to use a game controller. They wanna have a social gaming experience. And we have this platform that lets us ship a significant portion of that experience."
Valve is already looking at future upgrades for Big Picture, including auto-correct and context awareness, such as recognizing someone typing a web address in a browser might need '.com', Coomer said.
(images courtesy of Kotaku)
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text:
Baby Doll Bunting
24 comments:
- rachel griffith said...
SUPER cute vickie.
i might have to whip one of these up for miss melanie for christmas.
- December 20, 2009 at 8:09 AM
- whitey said...
What a great gift idea but I am afraid it would take me a day and a half just to get my sewing room organized enough to find everything I would need!
- December 20, 2009 at 8:17 AM
- Barb said...
What a great gift idea (especially with a baby doll thrown in for good measure!) Thanks.
- December 20, 2009 at 8:56 AM
- Shasta said...
Oh I love it! Thanks cute lady!
- December 20, 2009 at 9:05 AM
- Lois Grebowski said...
Oh that is just soooooo darn cute!!!! I can't wait until I get grandbabies!!!!
- December 20, 2009 at 9:30 AM
- PamKittyMorning said...
- December 20, 2009 at 10:56 AM
- Jackie said...
Vickie, Very cute!! Perfect for a little girl's dolly.
- December 20, 2009 at 11:27 AM
- Nancy said...
Well done.... You have a monderfull "chef" .....
Merry Christams
- December 20, 2009 at 12:33 PM
- Mountain Home Quilts said...
I'm making one for my daughter!! Thanks for the tutorial! :)
- December 20, 2009 at 1:14 PM
- PunkiePie said...
Love it! Very cute!!
- December 20, 2009 at 2:07 PM
- Mary on Lake Pulaski said...
Adorable Vickie!
- December 20, 2009 at 8:02 PM
- Lara said...
Dear Moda Bakeshop,
Please stop posting such wonderful items... Just when I think I am getting on top of my to do list, I visit the latest post and add to my list again.
PS - Vicki this is a sweet little gift... I'll pop one on my list of little girl gifts for the birthday round next year! Thank you!
- December 20, 2009 at 8:29 PM
- V and Co. said...
cute vickie!
- December 20, 2009 at 10:14 PM
- Kelly O. said...
LOVE this!
- December 21, 2009 at 6:50 AM
- Emily said...
This will be so great!! Now I'll only have to help my daughter wrap up her baby once instead of every five minutes. She will love it as much as I will.
- December 21, 2009 at 9:19 AM
- eatmoresmores said...
Thanks for this tutorial. I whipped one up last night out of predominantly pink fabrics in my stash. I can testify that it only takes 45 min or so to complete. My little girl will love this for her baby dolls!
- December 21, 2009 at 2:18 PM
- CONNY*MADE said...
hello taht is very sweet,
i love that idee.
greatings conny
- December 24, 2009 at 6:38 AM
- HMG said...
Too cute!! I may have to whip one up right quick :-).
- December 24, 2009 at 1:08 PM
- Bonnie said...
OMG! I just love coming to your blog. There is always something exciting to see and try. I made the doll quilt from your tutorial and it came out pretty cute. Now, I am going to try this...only thing is, I'm not sure what top stitching is. This is too darn cute!
- January 4, 2010 at 5:51 PM
- Marie said...
This is so cute. I wonder if you could use a split zipper and then sew across the bottom once it was sewn in. That would eliminate the issue of difficult to sew because of the narrowness of the tube. Also, how much larger would it have to be for "newborn" size?
- January 20, 2010 at 6:36 PM
- krochet4kids said...
these would be great enlarged for a real baby, I have 2 new grandbabies coming this year and a niece or nephew as well so I will be busy sewing some....
- January 24, 2010 at 2:47 AM
- Sincerely said...
And done. From pressing fabric to quilting, this was completed in one nap for one very happy little girl and her "Sunshine Baby". Thanks for a sweet and easy to follow tutorial.
- January 27, 2010 at 1:51 PM
- Joann said...
I made this for my granddaughter for her birthday. Made the ABC book with the LoveU fabric panel and charm pack. Purchased an extra charm pack and instead of using the layer cake, used 20 charm squares for the top.
- January 31, 2010 at 11:41 AM
- Sarah said...
I'm almost done with this for a present for my daughter however the bulk is so much that I can't fit it under to make the tube under my presser foot. Any advice would be appreciated.
Thank you,
- December 6, 2010 at 10:32 PM


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ASCO Cancer Treatment Summaries and Survivorship Care Plans
These downloadable forms help breast and colon cancer survivors assemble a care plan; forms for additional types of cancer are coming soon. ASCO also provides summary forms for doctors to record treatments, which can be shared with others involved in follow-up care.
Lance Armstrong Foundation Survivorship Worksheets
Several tools can help cancer patients organize information about their care, including a Cancer Survivor's Medical Treatment Summary (PDF - 842KB), which contains sections for suggested follow-up care.
OncoLife Survivorship Care Plan
This online tool helps patients and their healthcare teams keep track of cancer treatments received. The tool then generates a list of potential late side effects of treatment that patients and their doctors should monitor.
National Coalition for Cancer Survivorship
Elements of a successful survivorship care plan are listed here. The coalition's Web site also includes the Cancer Survival Toolbox® module, an audio teaching program that includes survivorship issues.
Institute of Medicine Survivorship Care Fact Sheet (PDF - 88KB)
This document outlines the elements that should be included in a survivorship care plan, as well as questions that patients should ask their health care providers.


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Bass Player Needed, International Shows Booked (Watford, Herts)Post reply
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Products >
Cell_Biology_and_Epigenetics >
Apoptosis_Kits >
The ApoAlert Caspase Assay Kits provide a simple and convenient way to detect caspase protease activity using fluorometric or colorimetric methods. We offer caspase detection assays in two formats: assay kits and 96-well plates. The assay kits detect caspase activation by assaying for the cleavage of a fluorescent or a colorimetric substrate. The entire protocol—from collection of cells to fluorometric or colorimetric results—takes only 90 minutes.
The Caspase-3 Colorimetric Assays measure the proteolytic cleavage of the chromophore p-nitroanilide (pNA) by caspase-3. Liberated pNA can be monitored colorimetrically by absorbance at 405 nm.
The Caspase-9/6 Fluorescent Assay detects the shift in fluorescence of 7- amino-4-methoxy coumarin (AMC). Upon cleavage, AMC fluorescence can be measured using a 380-nm excitation filter and a 460-nm emission filter. Fluorescence detection is highly sensitive and can be used to measure even very small amounts of active caspase.
The Caspase-3 Fluorescent Assays detect the shift in fluorescence emission of 7-amino-4-trifluoromethyl coumarin (AFC). After the substrate is cleaved by the protease, AFC emits a yellow-green fluorescence at 505 nm if excited at 400 nm.
Oftentimes, depending upon the specific cell type as well as the apoptotic stimuli used, one or more caspases will become activated. The ApoAlert Caspase Profiling Assay Plate can be used to simultaneously analyze several different caspases in your sample, with up to 24 wells available for each caspase.
The ApoAlert Caspase Profiling Plate measures the activation of four different caspases (caspase-2, -3, -8, and -9) using a fluorometric method in a convenient 96-well format. Caspase profiling plates make it easy to profile caspase activities in a variety of cell lines after treatment with different apoptotic stimuli.
The ApoAlert Caspase-3 Assay Plate provides a convenient way to monitor caspase-3 activity in up to 96 samples at once. No handling of caspase substrates is required, allowing for easy detection of caspase-3 activity in a variety of samples. Caspase-specific inhibitors are included for your control needs.
Testing samples is easy because the fluorogenic substrates specific for particular caspases are already immobilized in the wells of our 96-well plates—eliminating the need for additional handling of caspase substrates. When cell lysate containing activated caspase is added to a well, the immobilized fluorogenic substrate is cleaved by the corresponding activated caspase, releasing a fluorescent product that can be easily detected using a standard fluorescence plate reader.
These kits measure one of the earliest indicators of apoptosis—caspase proteolytic activity
Please see the product's Certificate of Analysis for information about storage conditions, product components, and technical specifications. Please see the Kit Components List to determine kit components. Certificates of Analysis and Kit Components Lists are located under the Documents tab.


text:
WISCONSIN DELLS, WI (UWSP) - The UW-Stevens Point women's basketball team forced Ripon into 28 turnovers on their way to a 55-44 victory over the Red Hawks.
Sam Barber (Schofield, WI/D.C. Everest/Winona St.) knocked down a three-pointer six minutes into the game, putting the Pointers up 9-8, and they never trailed again. UWSP led by as many as 16 points in the game, which came midway through the second half.
Liz Althoff (Darien, WI/Clinton) came up big for UWSP posting 17 points, going 8-for-10 from the charity stripe and pulling down seven rebounds.
Barber came up just shy of a double-double, posting 16 points and eight rebounds on the evening.
Sophomore Kailtyn Jacobs tied for a game-high eight rebounds, a career-high for her.
Jill Can Eperen and Erin Lind both tallied 14 points for the Red Hawks.
UWSP returns to action Saturday night as it returns home to host Edgewood College in a non-conference match-up. Tip-off set for 6 p.m.
This link takes you to UWSP Pointer Athletics web page: Pointers go 2-0 in the Dells


text:
Elephant Ears
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- Elephant Ears
- Upright Elephant Ears
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- Elephant Ear Purple Giant


text:
Allison, do you have a link to your story? I'm sure many of us haven't read it.
Laurie, I'll give your business name some thought, too,
Remember Lou Giglio who hosts the Passion Conference every year in Atlanta? This January 60,000 college students attended. (Tim went last year as a counselor) Anyway, because Lou's church in Atlanta had raised 2 or 3 million dollars to fight human trafficking, he was invited to offer to pray the benediction at the president's inauguration. Then someone dug up a sermon that Lou preached 15 or 20 years ago in which he talked about the gay lifestyle and how it threatened our families. Lou said he knew that's all the media would report about his benediction prayer so he has withdrawn his name from the inauguration. Here is the link from the Washington Post. I knew Carol, Laurie and some others on the Porch have listened to Lou.
http://www.washingtonpost.com/blogs/pos ... -comments/


text:
Motor: Two "Balanced" Centrifugal Blowers. 1270 CFM @ 4.6 Sones.
Controls: Variable for full control of both Power & Light. Can be ordered with Remote Wall switch capability.
Lighting: Uses 50 Watt Halogen Spot lights in the Center Panel (Par-20) and four 75 Incandescent bulbs behind the filters. Bulbs not included.
Heat Sensor: Includes Fire Safety Thermostat that will turn unit on when temperature reaches 130 degrees.
Electrical: 115 AC, 60 Hz, 15 amps. Suggested use with a 15 amp circuit.
Filters: Full bottom coverage Aluminum Mesh Filters for easy cleaning.
Finish: 304 Stainless Steel, Powder Coating in Black or White.
Duct: Two 7" round or 8" round to vents.
Damper: Built-in Back Draft damper standard.
Install: Suggested distance between the cooking surface and the bottom of the hood is 30" to 36"/
Duct Coverings: Custom size stack and wood frame made to fit each installation. To determine the size of the stack the ceiling and mounting heights are needed.
Frame: Wooden Support structure is included with the stack for a strong, safe installation.
Warranty: Limited Seven Year In Home Warranty covering Parts & Labor.
Grill: No performance warranty when used over a Bar-B-Que Grill.
Stack Includedup to 48 High
Optional Power Booster
Increase Performance by 20% with Power Booster on all blower models. Takes a 7 vent to 8 vent.
Optional Power Booster
Increase Performance by 20% with Power Booster on all blower models. Takes a 7 vent to 8 vent.
Shipping Weight: 65 lbs
Shipping Method: UPS


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Low Cost!
Our cost is one fifth than any First World Country while serving the same quality Globally.
1st ISO 9001:2008 certified Clipping Path company in this Industry. Try us to find what benefits you can have by outsourcing your needs.
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Are you looking to outsource your imaging editing, animation, multimedia and Graphic Design Tasks? Now you can concentrate on your core business or creative activities by outsourcing your diverse photo editing, high end photo retouching, multimedia, graphic design, Animation and other creative tasks to us. Clippingimages.com is an International Graphic Design Outsource provider and established in June 2004. Located at Victoria, Australia & Dallas, USA, you will be benefitted greatly by getting low cost service as our in house production is located in low labor cost region Dhaka, the capital of Bangladesh with availability of skilled graphic artists.
Our retouching agency can help you out with any form of retouching such as advertising retouching, fashion & jewelry retouching as well as wedding photo retouching with advanced photo enhancement & photos restoration apart from cost-effective Photoshop masking service online from Indian Sub Continent. Till date, we have been recommended by more than 500 Industry specialists to save cost and time! Get quality service at fast turnaround time with state-of-the-art infrastructure and cost-effective production in one place here.Read more about us
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DOUGLAS, Ariz. (AP) - A port of entry in southwestern Arizona was briefly closed Sunday morning in response to a report of a bomb that turned out to be a false alarm.
The Cochise County Sheriff's Office says a woman making an anonymous call told authorities that a vehicle that was going to travel into the United States through the port of entry at the Arizona city of Douglas would have a bomb in its back seat.
The sheriff's office says port workers later stopped a sedan that was headed northbound through the port and was carrying a man, woman and children.
The agency says no suspicious items were found in the car.
The sheriff's office says it was notified of the situation before 2:30 a.m. Sunday.
The port was reopened at 4:30 a.m.
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text:
Deftones will play a secret MTV show in London at ULU on May 12. Pre-order Diamond Eyes from UKU now to receive a ticket!
Check out the official trailer for Diamond Eyes, available everywhere this Tuesday!
Check out Part 2 of Deftones discussing the creation of Diamond Eyes. The second installment focuses on bassist Sergio Vega's impact on the creative process.
Check out Part 1 of an interview with Deftones taken by 13th Witness about the creation of Diamond Eyes. In the first installment, the guys talk about their philosophy and intent during the writing process.
Click Here for the official Diamond Eyes album countdown widget... 6 days and counting!
Grab, Share and spread the word!
Due to overwhelming demand, some more tickets have been made available for the April 29 show at Concrete Street Amphitheater in Corpus Christi. Click here to buy yours while they last.
Deftones' new single "Diamond Eyes" is now available in the UK!
Download the single on iTunes now.
Keep your eyes peeled for a very special Deftones show to be announced soon with tickets available exclusively through UKU. Also, if you missed out on the limited "Rocket Skates" 7-inch on Record Store Day, you can grab one for a limited time through the UKU store here.


text:
Weekend readers' pictures: Feast
The next topic is Run (to appear 28 July). Email a hi-res image (one per entry), plus a sentence or two about what inspired you to take your photo, to email@example.com by noon on Wednesday 18 July; please supply a daytime telephone number. Conditions apply – go to guardian.co.uk/theguardian/weekend/in-pictures-terms-and-conditions for full terms and conditions


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- My Account
- Tell a Friend and Save
- Order Toll Free 1.800.727.9077
Virtual Wall®Item Number: 4960
A Virtual Wall prevents your home robot from entering off-limit areas. Each emits an adjustable infrared beam (up to 8 feet) that the robot will not cross. Requires 2 D batteries (not included). Compatible with iRobot Dirt Dog®, iRobot Roomba® 400 Series (excluding SKUs 43501 and 44001), Discovery Series and Original Series.
In-Stock, usually ships in 1 - 2 full bus. days (Details)
In-Stock, usually ships in 1 - 2 full bus. days (Details)
Order Toll Free: 1.800.727.9077
Virtual Wall® Full Specifications
- Sends an infrared signal to create a 'virtual wall' of up to 8 feet
- Blocks off-limit areas
- Create a barrier that the robot will not cross
- 1 Virtual Wall (requires 2 D batteries, not included)
- Documentation
The iRobot limited warranty shall not apply to failures or problems which are caused by products or equipment not authorized by iRobot Corporation.
Country of Origin:China


text:
DOJ's Stimulus Reporting Scofflaws
The new list is out on Recovery Act recipients that failed to file quarterly spending reports as required by law and it's a bit surprising.
Nearly 46 percent of the Recovery scofflaws, it turns out, received grants from the Department of Justice, the nation's principal law enforcement agency. For the most recent quarter, 303 reports were listed on the Recovery Board's Wall of Shame, our nickname for the list of non-compliers compiled on Recovery.gov. Of those, 139 involve grants issued by the Justice Department to cities, counties, police departments, sheriff's offices and others.
Some of these law enforcement agencies received grants under the federal COPS program, which promotes community policing in state, local, territory and tribal law enforcement agencies. The reasons for non-compliance varied, according to the Justice Department. Some recipients said they did not have the personnel available to fill out reports and submit them to the Recovery Board. Others experienced technical difficulties, and some simply said their failure was unintentional.
Big and small law enforcement agencies failed to report, including the City of Pittsburgh's police department. It blamed technical problems and failed to submit reports for the last two quarters on its use of a $144,000 COPS grant.
There was some good news, however: Fewer and fewer recipients of Recovery Act funds want to be featured on the Wall of Shame. For the quarter ending March 31, recipients submitted 138,814 spending reports to the Board. Of the 303 reports not filed—the lowest number in the history of the program—most were one-time offenders. The missing reports involve nearly $1.2 billion in Recovery awards.
Here's a glimpse at some recipients that failed to report to various agencies:
- The City of Richmond, CA, failed to report in three consecutive quarters on its use of a $4.3 million grant from the Department of Homeland Security. Its explanation, according to DHS: "None given.''
- Stephentown Regulation Services LLC, Stephentown, NY, did not submit a report for two quarters on a $43.1 million loan guarantee from the Department of Energy. The reason, according to DOE: "Recipient declared bankruptcy.''
- The office of the Arizona Attorney General did not submit a report on a $2.9 million grant from the Justice Department. The recipient said its failure was unintentional.
- The City of Fairfield, CA, failed to report on $4 million in grants from the Federal Transit Administration. The FTA said it will suspend the grant payments if the city does not submit a report in the next quarter.
- The Milwaukee County Transit System said it forgot to submit a report on its use of a $25,682,975, grant, according to the FTA, which plans to suspend the grant payments if the transit system fails to file a report in the next quarter.
- Northrop Grumman Systems Corporation failed to submit a report on a $3.1 million contract issued by the Social Security Administration. The SSA said that "the individual [in Northrop Grumman] responsible for reporting on behalf of the recipient indicated he forgot the due date for the report."
– Michael Wood, Executive Director, Recovery Board
2 Responses
Thanks for releasing the reply. Not sure why I didn't see it yesterday when I was here. None the less, it's good that some of the administrative tasks are getting resolved.
[...] While missed reports are a phenomenon likely as old as government grants, what is new is that in the age of transparency, violators are much more publicly shamed. The Recovery Accountability and Transparency Board, which was created by the American Recovery and Reinvestment Act of 2009, runs a blog and a website which periodically posts the names of organizations who have failed to live up to the high expectations taxpayers have for stewardship of public funding. The most recent list, and an insightful post about these transgressions, can be viewed here. [...]


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There's debate about how a school in Georgia -- and the local police department -- handled a 6- year- old who apparently threw a violent temper tantrum. The school called police and kindergartner Salecia Johnson ended up taken away in handcuffs like any other crime suspect.
The school says she was pushing other students and running away from staff before the trouble escalated into slamming chairs around an office, and throwing over a shelf which then hit the school's principal in the leg. A police report says the girl also jumped on top of a paper shredder, tried to break a glass picture frame above it, and was biting a door knob.
An officer says he tried to calm the girl down but she resisted and started fighting with him. So he handcuffed her, put her in the back of his squad car and brought her to the police station.
The police department says its officer acted within the rules. Its policy for arresting suspects makes no distinction about age. Or, as the police chief put it, there is no age discrimination. Johnson's parents say in this case there should have been. They admit Salecia suffers from mood swings, but say the harshness of an arrest could cause long-term psychological damage. Johnson was originally charged with assault, and damage to property, but those charges are now being dropped because she's so young. There was also talk about her being expelled from school, but we've learned she's expected to be back in class next week
WTXF-TV330 Market StreetPhiladelphia, PA 19106-2796Phone: (215) 925-2929Fax: (215) 982-5494


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Starbucks® Stainless Steel & Ceramic Tumbler, 12 fl oz
A tumbler with an insulating stainless steel exterior and a ceramic inner lining.
- Product Details
Starbucks® Stainless Steel & Ceramic Tumbler, 12 fl oz
Enjoy the best of both worlds with this Stainless & Ceramic Tumbler. The stainless steel exterior helps keep hot beverages warm while hands stay cool, and the ceramic inner liner offers the satisfying experience of sipping coffee from your favorite coffee mug. The coffee tumbler's press-in lid features a silicone seal to help minimize spills and a purple accent color to rival spring flowers in bloom. Starbucks name on side. Holds up to 16 fl oz. Hand wash only. Do not microwave.


text:
A-Z Health Topics
Return to Index
(ED; Erectile Dysfunction; Male Erectile Disorder)
Venous Leak
Neurovascular Function
- Nerve dysfunction—can reduce feeling in the penis, resulting in impotence
- Diabetes —interferes with nerve signals
- Hardening of the arteries —can cause reduced blood flow
- Peripheral neuropathy , spinal cord injury, and surgery—can damage nerves
- Side-effects from medications
|Blood Vessels and Nerves of Male Pelvis
|Copyright © Nucleus Medical Media, Inc.
Psychological Factors
Risk Factors
- Age: 65 and older
- Race: Hispanic
- Obesity
Medical conditions:
- Diabetes
- Hardening of arteries
- Chronic kidney disease
- Liver failure
- Peyronie's disease—bending of the penis caused by scar tissue
- Endocrine disorders
- Neurological disorders such as multiple sclerosis , peripheral neuropathy , and stroke
- Hypertension
- Psychiatric disorders, such as anxiety and depression
Traumatic conditions:
- Vascular surgery
- Pelvic surgeries, particularly for prostate cancer
- Spinal cord injury
- Alcohol use
- Illegal drug use
- Anabolic steroid use
- Heavy smoking
- Interpersonal conflicts with a sexual partner
- Antihypertensives—for high blood pressure
- Antihistamines—common as allergy medication
- Antidepressants
- Tranquilizers
- Antipsychotics
Nocturnal Penile Tumescence Testing
Phosphodiesterase inhibitors
- Do not take these medications if you are also taking nitrates.
- Oral testosterone , if you have low testosterone levels
- Alprostadil , either injected into the penis or inserted into the urethra as a suppository
Vacuum Devices
- Plastic cylinder for the penis
- Hand pump for pumping air out of the cylinder
- Elastic band for holding the erection after removal of the cylinder
Vascular Surgery
Penile Implants
|Penile Implant
|Copyright © Nucleus Medical Media, Inc.
Sex Therapy
- Ineffective sexual techniques
- Relationship problems
- Anxiety
- Depression
- Take medications to manage blood pressure , diabetes, or depression.
- Ask your doctor about changing medications.
- Maintain a healthy weight .
- Eat a healthful diet .
- If you smoke, quit . Smoking is significantly associated with impotence in older men.
- Talk to a therapist or counselor.
American Academy of Family Physicians http://familydoctor.org
Urology Care Foundation http://www.urologyhealth.org
Canadian Urological Association http://www.cua.org
SexualityandU http://www.sexualityandu.ca
Erectile dysfunction. EBSCO DynaMed website. Available at: http://www.ebscohost.com/dynamed/what.php . Updated August 8, 2013. Accessed August 22, 2013.
Erectile dysfunction. National Institute of Diabetes & Digestive & Kidney Diseases website. Available at: http://kidney.niddk.nih.gov/kudiseases/pubs/ED/index.aspx . Updated March 28, 2012. Accessed August 22, 2013.
Erectile dysfunction. Urology Care Foundation website. Available at: http://www.urologyhealth.org/content/moreinfo/ed-factsheet.pdf . Updated 2009. Accessed August 22, 2013.
Viera A, Shenenberger D, Green G. Am Fam Physician. 199 Sep 15;60(4):1159-66. Available at: http://www.aafp.org/afp/1999/0915/p1159.html . Updated December 2006. Accessed September 17, 2012.
Revision Information
- Reviewer: Adrienne Carmack, MD
- Review Date: 09/2013
- Update Date: 09/30/2013


text:
Cheap ski holidays in hundreds of ski resorts worldwide.
Nb: infants must be under the age of 2 and
children must be under the age of 12 at the time of
The family-run Marmore has been welcoming British guests for many years. It is right in the centre of Cervinia, 150 metres from the Cretaz lifts and close to the ski school meeting place. It offers comfortable accommodation and relaxed service.
37 Rooms:
Iglu acts as a travel agent for disclosed principals/tour operators, further details
of which will be made available at the time of booking. Your holiday contract will
be bound by the tour operators terms and conditions.
Prices are shown for a basic room or unit, can be subject to change and are indicative
until time of booking. Please call on 0208 544 7114 for prices for other travel
and room options for this property.
Prices shown are per person per week based on maximum occupancy. Descriptions and
quality ratings are provided by the Tour Operator (or one of the Tour Operators
where similar holidays are offered by more than one supplier). We reserve the right
to make minor adjustments to the description or rating based on staff and customer
feedback. For payments by credit card, a 2.5% credit card charge (4% for AMEX) will
be added to your invoice. If you pay by a UK issued debit card, there is no charge.
All bookings are subject to a £5 per person Passenger Admin Fee charged by Iglu.com.


text:
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The Modern System of Healthcare is For The Animals
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And The Greatest Tag Team Was Born
They Just Might Have Chosen the Wrong Drummer for the Job
Pick Your Site Name
Tell me more


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Availability: Usually Ships Within 24-48 Hours
Incredibrace - Low Back Support Brace XX-Large 38-44 Inches
Made for everyday wear or with the athlete or medical patient in mind. Incrediwear patented braces can bring comfort to your ankle within minutes of putting them on, energizing individuals who need extra joint support. Incredibraces ankle brace can significantly enhance comfort and mobility, outcomes that occur due to increased blood flow, regulation of temperature, and delivery of a greater supply of oxygen to the targeted area. Most ankle supports simply support the injury; Incredibraces use the addition of a patented organic germanium bamboo charcoal blend making this brace ideal for anyone experiencing discomfort related to circulatory issues or anyone who has suffered a sports related injury, sprains, or injury from repetitive use. Increased blood can help to decrease swelling and increase mobility leading to a reduction in pain. Incredibraces are antimicrobial, odor absorbing and moisture wicking for supreme long wearing comfort. Incredibraces are the ideal choice for the active or inactive, sports enthusiasts, or those just seeking the best comfort available in a medically designed brace. Try it - you won't be disappointed!
Incredibrace Low Back Support Brace:
Miracles can happen by simply trying on an Incredibrace!Results have shown that most people experiencing pain who try Incredibraces begin feeling better within 20 minutes, sometimes even sooner! Incredibraces have provided relief to those suffering pain from sprains, meniscus tears, arthritis, rheumatoid arthritis, inflammation, cramps and fatigue. From world class athletes to those who have trouble even walking, Incredibrace wearers have experienced pain reduction and a greater range of motion while walking, working, running, biking, dancing, competing in martial arts, lifting weights and even sleeping.
Therapy without a prescription and accelerated recovery!Incredibraces are constant therapy. Yes, therapy. Infrared therapy has been used for years at Medical clinics to treat vascular and circulatory conditions. Physical Therapists and Chiropractors have used infrared therapy to accelerate recovery. Incredibraces are made with a special material that cannot be washed out. This material, when heated by the body, releases infrared anions (negatively charged, there are no electric shocks). The anions vibrate tissue and create an increase in blood flow. The increased blood flow carries fresh oxygenated blood into areas that are swollen, due to injured tissue, and flushes away the deoxygenated blood, chemicals, and debris. This process results in a decrease in swelling and pain and an increase in range of motion!
Frequently Asked Questions
Are there any side effects?None, except that you feel better faster and recovery is accelerated.
How should Incredibrace be worn?Daily, and as many hours per day that you can! Sleeping with the Incredibrace is ideal as the body heals while at rest! 24/7 is great! Wear the Incredibrace for 6-8 weeks minimum, even after the pain has subsided. Just because pain is gone does not mean the body is finished healing! Arthritis sufferers should wear the Incredibrace constantly, and after several weeks will notice an increase in range of motion and reduction of pain. These people should try wearing the Incredibrace for years to see if their arthritis reverses itself.....that would be an excellant endorsement!
What happens if I put it on an area that has no pain while I am exercising?They have heard from bikers, runners, backpackers, and karate gurus, who have worn the knee brace on their thighs, and report that their legs don't seem get as tired! they do not make any claims regarding increased endurance, but it is logical to ponder the benefits of increased oxygen to tissue and the potential to reduce lactic acid build up in muscles during exercise.
Will Incredibraces help with cramps?Yes, the primary treatment for cramps is motion to stimulate increased circulation.
Do you have other Incredibraces?Yes, of course, the successes of the braces are nothing short of incredible........so they've invented braces for the wrist, elbow , ankle and back! And more are coming soon.
Can I wash the Incredibrace?Yes, and you can put it in the dryer too, but it may shrink.....the effectiveness of the Incredibrace can not be washed out. For best results machine wash in cold water and hang dry.
About Incrediwear/IncredibraceIncrediwear was created to improve the lives of our customers through the use of our products. Our goal is to design lifestyle enhancement products that offer significant results for our loyal customers on an ongoing basis. We continually strive to create innovative products of the highest quality, like nothing else in the marketplace. Star Nutrition prides itself on providing innovative, all natural nutritional supplements, vitamins and other over the counter health care products. We believe that taking care of your body should be your number one priority. Incrediwear tm is a way of life, so join the Incredi-movement in your journey to better health!
Mission:To continually enrich the quality of life of our customers.
Core Focuses:
About Star NutritionStar Nutrition prides itself on providing innovative, all natural nutritional supplements, vitamins and other over the counter health care products. Creating safe and effective alternatives to potentially hazardous prescription medication is Star Nutrition's goal. Star Nutrition's mission is to enhance the quality of life of our customers through our products. Star Nutrition is committed to your sustained health. Star Nutrition believes that taking care of your body should be your number one priority. Star Nutrition is a way of life, so join Star Nutrition in your journey to better health.
Quality and SafetyWhat separates Star Nutrition Inc. from other companies is that Star Nutrition is committed to safety and quality. All Star Nutrition products are manufactured with ingredients that are certified for Good Manufacturing Practices (GMP). GMP are determined by various aspects of manufacturing including cleanliness, strict employee regulation, quality control, etc. Only the purest, finest quality, all-natural ingredients are used in all of Star Nutrition's products.
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Aliesha's Q & A
Who's your favorite sports team, and why?
Welllll I have to admit, I do not have a favorite sports team. I enjoy playing sports rather than sitting and watching them on TV. So I would have to say my softball team is my favorite sports team, and why, because we kill it. I am a tomboy who knows how to play, bait her own hook, and shoot a target in front of her. Then, I am also a classy lady who puts on her pearls and stilettos with a glass of wine at dinner.
What's your favorite movie quote?
"Don't take life too seriously, you'll never get out alive." I think that quote sums it up! You have to live life every day like its your last regardless of what you are doing. No regrets!
What's your favorite video game, and could you kick our butts at it?
Mortal Combat, Super Nintendo style!!!! I could epically kick your butt! I'd blow your mind.
Piercings/Tattoos (How many? Where?)
I have my nose and my belly pierced. I love the way a belly ring looks on a female, when you wear a classy one. The story behind my nose is; I was in Italy with my dad for my 18th bday, and we say the culture there. Everyone had their nose pierced so we thought it would be a nice birthday gift and would "fit in" to the crowed if I got it done.
What's the most embarrassing song on your iPod?
Hahahaha wellllll, I'd have to say a Justin Beiber song (No offense beebs). I think it is amazing what talent he has however, I am not a teen heartthrob lover. I had no idea it was Justin Beiber until I saw the title during my workout. I thought to myself wow, I guess he reached puberty - good for him!
What's your best party trick?
My best party trick is being completely cocked and no one being able to tell...
What's the most memorable pick-up line you've ever heard?
Mine are more subtle; I seem to always get, "I seem to be thinking about you a lot lately, that must be a good thing, lets go grab lunch." The main line is I've been thinking about you a lot lately..
What's the worst job you've ever had?
Oh gosh, I am 26 and between the ages of 16-21, I had 17 or 20 different jobs. I think every retail one I ever had SUCKED. If I had to pick one, I would have to pick.....Tropical Beauties in Naples, FL. The owner was named Conchita - yes, that is her name. She had a harsh European accent and her deal in the store was always, "Buy one at full price, get the second half off". Great deal, surely. BUTTTT if you saw how insanely busy this store was, you'd never even want to step foot in it because you wouldn't know where to start looking. I actually still have pictures of what that store looked like. She was 6ft. tall, her husband was short and pervey...It was just an odd place to work and I couldn't WAIT to get out of there!
What's the most dangerous thing you've ever done?
The most dangerous thing I have ever done was on accident. I was in Italy, snowboarding the mountains of Courmayeur. Apparently you have to be careful and stay on the trails because if you go down the wrong side you are in another country, Switzerland I believe it was. Of course, that exact thing happened to me: I went the wrong way. By the time I found out, I had to take off my snowboard and hike my booty back up the mountain to the right place. That was so dangerous because I could have been so lost, never found, or not had a way to get back to any country since I didn't have any identification on me whatsoever!
It's 4AM after a crazy night out – what are we eating?
I am sure I can speak for almost everyone who is out at 4AM and all they want is fast food. I crave double cheeseburgers, large fry, and a small Dr. Pepper from McDonalds. Or two jr. bacon cheeseburgers with a med fry, with ranch and BBQ mixed together from Wendy's. Oh ya, my mouth just watered right now. I am a very tiny girl, but I can outeat ya any day.
What's the strangest thing in your fridge right now?
Depends on what you call strange.....If you think a stock pile of polynesian and Chick Fil-A sauce from Chick Fil-A is strange then there ya go lol. Their sauces are....yummmmmm.
What's the naughtiest thing you've ever done in public?
I am very modest, and a bit shy. So lol, honestly the naughtiest thing I have ever done would probably be, be sexual with my bf in public.
What do you feel sexiest wearing?
I feel sexy wearing a nice pair of fitted jeans with a very comfy fashionable tank. Nothing beats comfort.
Tell us a joke.
Hahaha, I think you'll laugh...Not at my joke, but how bad my jokes are. I can tell you a blonde moment....I have PLENTY of those!!!! My bf, gf, and I were all relaxing watching a movie - a movie that I had been itching to see for over a year!!! My Best Friend's Girlfriend was the movie, and it was accidentally bought as a blu-ray, and we don't have a blu-ray. Well, needless to say the movie goes on and I pass out.....I wake up and blurt out "I don't want to fall asleep because then it will be tomorrow." My gf Jordan busted out laughing because I just came out of sleep and the reality of if I go to sleep tomorrow will come...I guess you had to be there in order to get it lol.


text:
Cheap ski holidays in hundreds of ski resorts worldwide.
Nb: infants must be under the age of 2 and
children must be under the age of 12 at the time of
This charming chalet, set in a quiet residential area in the attractive Morel area above Méribel Centre was the former private home of the owner, so great care has gone into its style and upkeep. The spacious bedrooms all have en suite facilities and are tastefully furnished. The cosy living/dining-room makes a beautiful centrepiece to the whole chalet, with a log fire adding to the overall atmosphere. The Morel chair lift is only three minutes walk away, which takes you to the Altiport for excellent links to the Three Valleys. On your return at the end of the day, a blue run from the Altiport brings you within 150m of the chalet. Alternatively there is a ski-bus stop 200m from the chalet for the short bus ride to and from the lifts.
Ground Floor:
Entrance, Sauna, Ski room with heated boot rack
Room 1: Twin with bath/wc Room 2: Twin with shower/wc
First Floor:
Room 3: Twin and child triple with bath/wc Room 4: Twin with bath/wc and balcony
Second Floor:
Kitchen, lounge/dining room with fireplace and balcony, separate wcThird Floor (under eaves)
Room 5: Large twin/child triple (under eaves) with shower
For six days of the week the staff prepares all your meals.
Breakfast: We pride ourselves on giving you a great breakfast to start your day, with a choice of cereals, fresh fruit and juices, yoghurts, plentiful English tea and good filter coffee, bread freshly baked in our chalets each morning, cold meats, cheeses and preserves, and boiled eggs. This is normally presented buffet-style for you to help yourself. And to cap it all, we also cook a hot dish of the day for you six days per week, such as sausage and bacon or pancakes with fresh fruit, individually served.
On the chalet hosts' day off, they will prepare a Continental style breakfast for you, which will be left for you to help yourselves, and that evening you have the chance to eat out in one of the local cafés or restaurants – our resort team will be happy to provide some suggestions. In our Chalet Hotels, a full buffet breakfast (including hot option) is also served on the staff's day off.
Afternoon Tea: The traditional 'welcome home' after a day on the slopes will be laid out for you in your chalet or Chalet Hotel, ready for your return, every day except on the staff's one day off per week. A good cup of tea or coffee is the perfect accompaniment to a delicious slice of freshly home-baked cake and keeps hungry skiers happy until dinner is ready.Children's High Tea: In Chalets and Chalet Hotels with family guests, High Tea provides children under 13 years with a healthy menu, tailored more towards children's tastes and puréed food is available for infants on request. High Tea is at 5.30pm, and children do not join the main adult-only dinner. Families staying in one of our Chalet Hotels may choose to eat separately (High Tea at 5:30pm) or all dine together at the later adult dinner time if children who have received a child discount pay the meal upgrade charge at the time of booking only.
Dinner: A tasty and innovative, freshly cooked dinner will be prepared for you six nights per week by your Chalet Host - or by an experienced and professional chef in our larger chalets - and served with a choice of wines. Our four-course adult-only chalet dinners start with canapés and an apéritif, followed by an appetiser, main course and dessert, and completed by coffee with chocolates to round off your evening. Your choice of complimentary quality wines is unlimited during the meal service, and freshly chilled water is also of course always available.A special feature of our Chalet Hotels is a more extensive culinary experience for our guests. With the greater kitchen facilities of a hotel, our professional chefs are able to offer choices of menu at dinner, generally including lighter as well as more hearty options, and always a vegetarian choice for each course. Guests will be asked to choose their evening meals at breakfast for that evening from a varied daily selection. Vegetarian options are always on our 'Culinary Choice' menu in our Chalet Hotels, and are available in our chalets if you advise us in advance.
Iglu acts as a travel agent for disclosed principals/tour operators, further details
of which will be made available at the time of booking. Your holiday contract will
be bound by the tour operators terms and conditions.
Prices are shown for a basic room or unit, can be subject to change and are indicative
until time of booking. Please call on 0208 544 7114 for prices for other travel
and room options for this property.
The price shown includes 7 nights accommodation,
with flights from Southampton.
Prices shown are per person per week based on maximum occupancy. Descriptions and
quality ratings are provided by the Tour Operator (or one of the Tour Operators
where similar holidays are offered by more than one supplier). We reserve the right
to make minor adjustments to the description or rating based on staff and customer
feedback. For payments by credit card, a 2.5% credit card charge (4% for AMEX) will
be added to your invoice. If you pay by a UK issued debit card, there is no charge.
All bookings are subject to a £5 per person Passenger Admin Fee charged by Iglu.com.


text:
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