text:
Bortezomib in Treating Patients With Relapsed or Refractory AIDS-Related Kaposi Sarcoma
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This clinical trial is studying the side effects and best dose of bortezomib in treating patients with relapsed or refractory AIDS-related Kaposi sarcoma. Bortezomib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.
AIDS-related Kaposi Sarcoma
HIV Infection
Recurrent Kaposi Sarcoma
Drug: bortezomib
Other: laboratory biomarker analysis
|Study Type:
|Study Design:
|Endpoint Classification: Safety Study
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Treatment
|Official Title:
|Single-Arm, Dose-Finding Pilot Trial of Single-Agent Bortezomib in Patients With Relapsed/Refractory AIDS-Associated Kaposi Sarcoma With Correlative Assessments of KSHV and HIV
- Maximum tolerated dose (MTD) based on the National Cancer Institute Common Terminology Criteria for Adverse Events (NCI CTCAE) v4.0 [ Time Frame: Up to 28 days ] [ Designated as safety issue: Yes ]
- Overall KS response rates based on the Response Evaluation Criteria in Solid Tumors (RECIST) [ Time Frame: Up to 1 year ] [ Designated as safety issue: No ]Exact binomial 95% confidence intervals will be computed.
- Changes in bortezomib in Kaposi's sarcoma associated herpesvirus (KSHV) copy number in peripheral blood mononuclear cells (PBMC) and plasma [ Time Frame: Up to day 29 ] [ Designated as safety issue: No ]Analyzed using the Wilcoxon signed rank test. The association between change in KSHV copy number with clinical response of KS tumors will be investigated with exact logistic regression.
- Association between change in lytic gene expression with clinical response of KS tumors [ Time Frame: Up to 1 year ] [ Designated as safety issue: No ]Investigated with exact logistic regression. Hierarchical clustering will be used to explore if gene expression patterns differ according to clinical response.
- Determination whether changes in KSHV viral copy number in PBMC and plasma occur in concert or independently with changes in viral antigen expression in biopsy specimens [ Time Frame: Up to day 29 ] [ Designated as safety issue: No ]Spearman's rank correlations will be calculated.
- Changes in bortezomib in levels of tumor survival and proliferation proteins and nuclear factor kappa-light-chain-enhancer of activated B cells (NFKappaB) gene target messenger ribonucleic acid (mRNA) levels [ Time Frame: Up to 1 year ] [ Designated as safety issue: No ]Analyzed using the Wilcoxon signed rank test.
|Estimated Enrollment:
|Study Start Date:
|January 2010
|Estimated Study Completion Date:
|September 2014
|Estimated Primary Completion Date:
|September 2014 (Final data collection date for primary outcome measure)
|Assigned Interventions
Experimental: Treatment (bortezomib)
Patients receive bortezomib IV on days 1, 8, and 15. Treatment repeats every 28 days for up to 8 courses in the absence of disease progression or unacceptable toxicity.
Patients undergo blood and tumor tissue sample collection periodically for correlative biomarker studies, including measurement of KSHV viral loads, gene expression analysis, measurement of APOBEC3G levels by IHC, and RNA analysis by reverse transcriptase-PCR.
Drug: bortezomib
Given IV
Other Names:Other: laboratory biomarker analysis
Correlative studies
Detailed Description:
I. Estimate the MTD of single agent bortezomib in subjects with AIDS-related KS.
I. Evaluate the clinical response of KS tumors to bortezomib. II. Evaluate the impact of bortezomib on HIV plasma viral loads and peripheral blood mononuclear cells (PBMC) APOBEC3G levels.
III.Determine the impact of bortezomib on KSHV. IV. Assess bortezomib effects on KSHV copy number in PBMC and plasma and whether changes in viral copy number measured in PBMC and plasma are associated with clinical response of KS tumors.
V. Monitor KSHV gene expression in KS biopsy specimens and PBMC pre- and post-bortezomib and assess whether changes in viral gene expression (i.e., to a lytic pattern) in tumor biopsy are associated with clinical response.
VI. Assess whether changes in viral copy number in PBMC and plasma occur in concert with or independently of changes in viral antigen expression in tumor biopsy specimens.
VII. Assess effects of bortezomib on proteins relevant to KS tumor survival and proliferation (i.e., P53, VHL, p27, HIF1-alpha) as well as levels of NFkappaB gene target mRNAs in tumor biopsies.
OUTLINE: This is a multicenter study.
Patients receive bortezomib IV on days 1, 8, and 15. Treatment repeats every 28 days for up to 8 courses in the absence of disease progression or unacceptable toxicity.
Patients undergo blood and tumor tissue sample collection periodically for correlative biomarker studies, including measurement of KSHV viral loads, gene expression analysis, measurement of APOBEC3G levels by IHC, and RNA analysis by reverse transcriptase-PCR.
After completion of study treatment, patients are followed up at 4 weeks and then every 3 months for up to 1 year.
|Ages Eligible for Study:
|18 Years and older
|Genders Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Adult patients with cutaneous AIDS-related biopsy-proven KS relapsed after or refractory to at least one other prior systemic therapy
- Patients must have cutaneous KS lesion(s) amenable to biopsy (either one lesion >= 12 mm or 3 >= 4 mm) in addition to at least 5 lesions measurable for assessment; all of these lesions must not have been previously radiated
- Must have been on stable anti-retroviral therapy for at least 12 weeks with a PI-based or NNRTI-based regimen of at least three drugs, with no intention to change the regimen for the duration of the study; patients who have a high likelihood of better HIV management with a new antiretroviral regimen should defer enrollment until the changes are in place and the new HAART regimen meets the 12 week criteria
- Serologic documentation of HIV infection at any time prior to study entry, as evidenced by positive ELISA, positive western blot, or other FDA-approved licensed HIV test, or a detectable blood level of HIV RNA
- Women of child-bearing potential must have a negative pregnancy test within 72 hours before initiation of study drug dosing; post-menopausal women must be amenorrheic for at least 12 months to be considered of non-childbearing potential; male and female subjects of reproductive potential must agree to employ an effective barrier method of birth control throughout the study and for up to 3 months following discontinuation of study drug; (Note: A woman of childbearing potential is one who is biologically capable of becoming pregnant; this includes women who are using contraceptives or whose sexual partners are either sterile or using contraceptives)
- ANC >= 1,000/mm^3; subjects may be receiving growth factor support to meet these criteria
- Hemoglobin >= 8.0 gm/dL; subjects may be receiving growth factor support to meet these criteria
- Platelets >= 100,000/mm^3; subjects may be receiving growth factor support to meet these criteria
- Total bilirubin =< 1.5 mg/dL; if the elevated bilirubin is felt to be secondary to indinavir or atazanavir therapy, then subjects will be allowed on protocol without any limit on the total bilirubin if the direct bilirubin is normal
- AST(SGOT) and ALT(SGPT) =< 2.5 X institutional upper limit of normal (ULN)
- Serum creatinine =< institutional ULN or creatinine clearance >= 50 mL/min/1.73 m^2 for subjects with creatinine levels above institutional ULN
- Pre-existing grade 3 or 4 peripheral neuropathy
Exclusion Criteria:
- KS that is improving in the 4 weeks prior to enrollment
- Symptomatic visceral KS (oral and lymph node involvement is eligible)
- Symptomatic pulmonary KS; asymptomatic pulmonary KS that is not limiting activities of daily living is allowable
- ECOG performance status greater than 2
- Expected survival < 3 months with standard KS treatments (i.e., radiation, paclitaxel)
- Concurrent active opportunistic infection (OI)
- Herpes zoster (shingles) outbreak within the last 6 months or inability to take herpes zoster prophylaxis
- Patient is ≤ 5 years free of another primary malignancy except if the other primary malignancy is neither currently clinically significant nor requiring active intervention, or if the other primary malignancy is a localized squamous or basal cell skin cancer or cervical/anal carcinoma in situ
- Acute treatment for an infection or other serious medical illness within 14 days prior to study entry
- Patients may not have had anti-neoplastic treatment for Kaposi sarcoma (including chemotherapy, radiation therapy, biological therapy, or investigational therapy) within 4 weeks (6 weeks for nitrosourea or mitomycin-C) of study treatment
- Prior treatment with bortezomib or other investigational proteasome inhibitors
- Previous local therapy of any KS indicator lesion within 60 days, unless the lesion has clearly progressed with enlargement since the local therapy
- Use of any investigational drug or treatment within 4 weeks prior to randomization
- Physical or psychiatric conditions that in the estimation of the investigator place the patient at high risk of toxicity or non-compliance
- Hypersensitivity to boron
- Subjects with grade III/IV cardiac disease as defined by the New York Heart Association criteria. (e.g., congestive heart failure, myocardial infarction within 6 months of study)
- Subject has an acute or known chronic liver disease (e.g., chronic active hepatitis, cirrhosis); subjects with known hepatitis B or C infection may be enrolled if they have either documentation of no or minimal fibrosis on liver biopsy or undetectable hepatitis virus on PCR
- Systemic corticosteroid treatment, other than replacement doses
- Female subjects who are pregnant or breast-feeding
Please refer to this study by its ClinicalTrials.gov identifier: NCT01016730
|United States, California
|University of California at Los Angeles (UCLA )
|Los Angeles, California, United States, 90095
|University of California San Diego
|San Diego, California, United States, 92103
|United States, Maryland
|Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Hospital
|Baltimore, Maryland, United States, 21231
|United States, Massachusetts
|Boston Medical Center
|Boston, Massachusetts, United States, 02118
|United States, New York
|Memorial Sloan-Kettering Cancer Center
|New York, New York, United States, 10065
|United States, Washington
|Virginia Mason Medical Center
|Seattle, Washington, United States, 98101
|Principal Investigator:
|Erin Reid
|AIDS Associated Malignancies Clinical Trials Consortium
No publications provided
|Responsible Party:
|National Cancer Institute (NCI)
|ClinicalTrials.gov Identifier:
|NCT01016730 History of Changes
|Other Study ID Numbers:
|Study First Received:
|November 18, 2009
|Last Updated:
|August 15, 2014
|Health Authority:
|United States: Food and Drug Administration
Additional relevant MeSH terms:
HIV Infections
Acquired Immunodeficiency Syndrome
Sarcoma, Kaposi
AIDS-Related Opportunistic Infections
Neoplasms, Connective and Soft Tissue
Neoplasms by Histologic Type
Lentivirus Infections
Retroviridae Infections
RNA Virus Infections
Virus Diseases
Sexually Transmitted Diseases, Viral
Sexually Transmitted Diseases
Immunologic Deficiency Syndromes
Immune System Diseases
Slow Virus Diseases
Herpesviridae Infections
DNA Virus Infections
Neoplasms, Vascular Tissue
Opportunistic Infections
Parasitic Diseases
Antineoplastic Agents
Therapeutic Uses
Pharmacologic Actions
ClinicalTrials.gov processed this record on September 22, 2014


text:
Leakey replacement named
Wednesday 30 March 1994
Newcastle winger is in Argentina having chemotherapy
Returning to the stage after 20 years makes actress feel 'nauseous'
Man's attempt to avoid being impounded heavily criticised
- 1 Scottish independence: Ireland since 1919 is a lesson for Scotland in what a Yes vote means
- 2 A bottle of wine a day is not bad for you and abstaining is worse than drinking, scientist claims
- 3 Grandmas keep accidentally tagging themselves as Grandmaster Flash on Facebook
- 4 Daniele Watts: Django Unchained actress detained by Los Angeles police after being mistaken for a prostitute
- 5 Kanye West halts concert after two fans don't stand up - doesn't realise one is in wheelchair and the other disabled
Islamic State: Pope is 'being targeted by Isis', Iraqi ambassador to the Holy See warns
Jennifer Lawrence and Kate Upton nude pictures exhibition cancelled after artist concedes photos were 'stolen property'
Scottish independence referendum: A nation divided against itself
John Travolta addresses former pilot's gay romance allegations publicly for the first time: 'That was the lowest I'd ever felt'
Richard III: Two years after his body was found scientists discover how he died
Daniele Watts: Django Unchained actress detained by Los Angeles police after being mistaken for a prostitute
The political class is doing what Hitler couldn't – destroying Britain
Scottish independence: Nationalist leader Jim Sillars threatens pro-union companies with 'day of reckoning' after independence
Scottish independence: Yes campaign feels the heat as Alex Salmond's NHS claims come under furious attack
Portuguese academic says British are 'filthy, violent and drunk'
£23m Birmingham cycle scheme is attacked by Tory councillor for not catering to the elderly
i100: A single mother on benefits who became one of the world's most successful authors
11 rags-to-riches underdog success stories
Forget top summer reads
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Brogues vs trainers. The great winter coat debate. Shape-shifting silhouette PLUS win the edit
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Jake Bugg: "I'm the one I have to answer to…"
Fresh out of his teenage years, singer-songwriter Jake Bugg has achieved the kind of success that most aspiring musicians can merely dream of.
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subset: commoncrawl


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Located halfway between Toronto and Niagara Falls, Hamilton, Ontario is the third largest city in Ontario. Hamilton International Airport (YHM) is just ten kilometres from our Crowne Plaza hotel in Hamilton.
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text:
Ol' Fred had been a faithful Christian and was in the hospital near death. The family called their preacher to stand with them.
As the preacher stood next to the bed, Ol' Fred's condition appeared to deteriorate and he motioned frantically for something to write on.
The pastor lovingly handed him a pen and a piece of paper, and Ol' Fred used his last bit of energy to scribble a note, then suddenly died.
The preacher thought it best not to look at the note at that time, so he placed it in his jacket pocket.
At the funeral, as he was finishing the message, he realized that he was wearing the same jacket that he was wearing when Ol' Fred died. He said, "You know, Ol' Fred handed me a note just before he died. I haven't looked at it, but knowing Fred, I'm sure there's a word of inspiration there for us all."
He opened the note, and read, "Please step to your left - you're standing on my oxygen tube!"
You'll always find something to laugh with your friend Smokin' Joe Cassady
By Foodstories (Own work) [CC-BY-SA-3.0 (http://creativecommons.org/licenses/by-sa/3.0)], via Wikimedia Commons


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Helsinki Commission on Opening of Europe's Largest Human Rights Meeting
WASHINGTON U.S. Senator Ben Cardin (MD), Chairman of the Commission on Security and Cooperation in Europe (U.S. Helsinki Commission) and Representative Chris Smith (NJ-04), Co-Chairman of the Commission, released the following statement ahead of the Organization for Security and Cooperation in Europe (OSCE) annual high-level meeting on human rights. From September 22-October 3, civil society and government representatives of OSCE participating States will gather in Warsaw, Poland, for the annual Human Dimension Implementation Meeting to discuss compliance with the full range of OSCE human dimension commitments, with special focus on migrant rights, minority issues, and combating violence against women and children.
"The Human Dimension Implementation Meeting takes place while Russian aggression in Ukraine continues to threaten basic OSCE principles. I expect this will be a major focus of the meeting, as well as Russian actions at home that are cynically rolling back the ability of civil society to comment on or contribute to how that country functions," said Chairman Cardin. "I am pleased that Professor Brian Atwood will head the U.S. Delegation at this critical time. The promises OSCE states made to one another almost 25 years ago, that respect for human rights within any country is a matter of concern for all states, has guided us and must continue to do so. I also welcome the leadership of the U.S. Ambassador to the OSCE, Daniel Baer, who will be taking a high-level study group to the Auschwitz-Birkenau death camp."
Co-Chairman Smith said, "The Russian government's gross human rights violations in Ukraine must be a central topic of discussion at the Human Dimension meeting. HDIM is an indispensable tool for holding states accountable to OSCE commitments and most effective when both government and civil society representatives have equal opportunity to debate each state's human rights record. One issue that states and civil society must discuss this year in Warsaw, and at the OSCE "Berlin Plus 10" anti-Semitism conference in November, is the alarming rise of anti-Semitic incidents in the OSCE region. The OSCE must also continue to combat trafficking in human beings, including through fulfilling commitments taken last year to train transportation workers to identify possible victims and to improve law enforcement information sharing internationally on potential sex tourists. Commitments are made to be kept."
The Commission on Security and Cooperation in Europe, also known as the U.S. Helsinki Commission, is an independent agency of the Federal Government charged with monitoring compliance with the Helsinki Accords and advancing comprehensive security through promotion of human rights, democracy, and economic, environmental and military cooperation in 57 countries. The Commission consists of nine members from the U.S. Senate, nine from the House of Representatives, and one member each from the Departments of State, Defense, and Commerce.
Click here for more Statements
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I ask because - did anyone read the book Outliers? There's a bit in there about the age of children and their ability to learn math. Statistically speaking, those of us who were young for our class have issues.
I *shouldn't* be hanging out here, but needed a break. And you are all being TOO INTERESTING!
I was four when I started kindergarten (turned 5 that October) and I'm pretty good at math. Okay, I'm very good at math. Actually, I always got higher grades in math classes than my physics courses, eventhough I got all my degrees in physics. BUT: I was crappy at math until about fifth grade. An AWESOME teacher saw that I didn't suck, but was, in fact, bored to death. If it hadn't been for her, I probably would have thought I didn't like math and wasn't good at it. So it took a lucky break.
And I did read and LOVED Outliers. So interesting. Can't wait until I submit this thesis and I can read for fun again!
Alright. Back to work for me.
I see with my girls they're generally either really good at math or reading/writing. Bobbie is an excellent student, but English does come easier to her than math. Although she does take an advanced level math, so it's not like she's struggling to learn it. Jessica is the only one who started Kindergarten at 4, which she repeated.
I think I'm about half analytical and half artistic, not that they're totally separate. I paint, draw, write, play instruments, and also love the crisp logic of science (and can admire math even if I'm not intuitively successful at it).
My sister (born in November) has always been bad at math. I think it is partially psychological, and partially dyslexia. To this day, she cannot divide 600 by 6 without a calculator (she was trying to figure out her monthly insurance costs based on a twice-yearly bill).
I turned 5 in June and started K late August, so I guess on the younger side. I don't remember having any problems with math in early grade school (but DO remember having issues with writing and especially with cursive). I was also in part of the group that got a head start in 7th grade to take Algebra. Awesome teacher. He made it fun and interesting and got me the early year jump so I finished with AP Calculus my senior year.
I love the math classes (though I hated proofs in Geometry) and hated stuff like English and history. I was really thankful that my senior English class was AP, so that that C counted as a B. And my B in AP History counted as an A.
I confess I'm trying not to cry at work.
Jonathan reconnected with a high school buddy in OH about 5 years ago, Ron. He stayed overnight at our house in KC on his way to CA. One visit in the 16 years since HS. He's really been keeping in touch with him lately and they will talk on the phone or email and such. Ron was in a motorcycle accident a few weeks ago. Lost control in loose gravel and was thrown into a light pole. They put him in a medically induced coma for a week to give him time to heal. Both arms are broken (and J says they had to drain blood from one with a needle because of swelling) and he has pneumonia. They took him off the coma meds and said it may take him a while to come out because of his size (over 300 lb). It's been over a week and he's still not out. He has no insurance. They're not sure he's going to make and are talking about taking him off the machines next week.
Jonathan is devastated. We were making plans to go see him sometime and he was going to come to KC too. He has a 9 year old son. I am so sad. I liked him the first time I talked to him on the phone and the visit with him only solidified that.
In my case, though, I know it wasn't just being young for my grade because I went through psych/academic testing to qualify for special ed and performance is based on comparison to same age (year and month) peers, rather than grade level.
Lauren, CONGRATS! I'm so glad you got in.
Ashley, your girls are ADORABLE!
Me (40) DH (47) & furbabies * m/c 7/08 4/12 11/12
Interesting. I am an August kid, and so yes young for my class, and I was very bad at math. I think if I were to relearn everything now, I'd be excellent at it, because I have way better focus than I used to...I don't have any number issues...I like certain numbers more than others - but I think that's true of everyone, isn't it?
Just Midge
Oh, I'm sorry to see that Krista. How sad for your dh, and his friend's family and all.
Just Midge
And thank you for the congrats!
Bridget and Krista, hugs.
Me (40) DH (47) & furbabies * m/c 7/08 4/12 11/12
Krista, I'm so sorry for you and your DH, and your friend.
Am I just too sensitive lately?
I posted on FB that I got accepted to school, and was getting tons of congrats and all that, and then one person who I've known was just like "Congratulations."
That was it. No excitement, no nothing. Now, I'm not really a fan of her, but I get along with her for the sake of convenience, but seriously, could you just fake excitement with an exclamation point?
I guess I just feel if you're not really that enthused with someone's status, don't respond at all. It brought everything kind of down in my opinion, but I didn't say anything. What do ya'll think?
Ashley, I love, love, LOVE Charlie's face in your siggy. The look of shock just makes me giggle.
Lauren, I wouldn't read much into that - I never used exclamation points much before APA. I realized that I came off sounding abrupt or rude without meaning too. I don't think she would bother to say Congratulations unless she meant it.
Oh, and I forgot to say...
CONGRATULATIONS!!!! Way to go!
Last edited by girlwonder; 04-07-2010 at 08:58 PM.
"Any idiot can face a crisis; it is this day-to-day living that wears you out." -Anton Chekhov
I confess I just started KICKBOX again!!!
I love kickboxing so much, and I haven't really done it since I was pregnant. I am doing a 5 week course and am feeling so great to get back into it again. And it is so much fun because it is an impact course, so we are actually sparring, punching and kicking other people (and I get punched and kicked back ). We are all wearing pads so it doesn't hurt too much.
I love punching and kicking people! It is really fun to be stronger than you look. I've got a quick jab and a mean roundhouse. Look out!
"Any idiot can face a crisis; it is this day-to-day living that wears you out." -Anton Chekhov
And yeah, I'm sure she meant it sincerely.. I was just kind of like It must be just me, haha.
I wouldn't read too much into the lack of an exclamation mark either. I totally agree that it looks weird, but I bet it's just her writing style.
It sort of reminds me of a friend of mine. She's extremely polite and well-spoken IRL, but her writing style is so sloppy that I would probably think she was a bit rude/uneducated if I hadn't met her in person.


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- 1 Cities reel from ballooning Pima Animal Care costs
- 2 UA football: Should Arizona schedule harder nonconference games?
- 3 Gay marriage undermines traditional nuptials, state argues
- 4 As coach, Dykes still trying to find his way
- 5 Cats hope to end drought in Pac-12 openers
- 6 Estate gives $50 million for UA scholarships, research
- 7 Athlon Sports ranks Wildcats No. 3
- 8 Syphilis cases rise sharply in Pima County
- 9 Man arrested in car break-ins
- 10 Sahuarita town attorney cited for DUI
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Moderators: Jenise, David M. Bueker, Robin Garr
Dale Williams wrote:Nice note. I've really enjoyed the 2010, just drinking them to fast.
Anyone had the 2011 Lapierre yet? I'm enjoying the Beaujolais vintage (more like 2009 in style than 2010) but haven't had Lapierre yet.
David M. Bueker wrote:
We need them both.
Rahsaan wrote:David M. Bueker wrote:
We need them both.
Fine point, but in all fairness different people have different levels of interests in different regions. So some people will be more vintage-sensitive for certain wines.
ChaimShraga wrote:Just had the Thevent Morogon VV 2010. An amazing wine.
Bob Parsons Alberta wrote:Lapierre just posted>
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I thought this was pretty cool. I had never heard of anyone singing the same song to their pet every day. I guess it's similar to a parent singing a familiar lullaby to calm a child.
YouTube Description: "Rev's song I've sang this to him since he was a pup....his response to it is
pretty adorable. The city noise at the beginning of the song wakes him up from
his sleep and..."
I like it.
If you're curious, the song is 'Make You Feel My Love' by Adele.


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I will give you 1000 DA pointsHey!
I have some extra points and I would like to give them away because why not? I hope I will make someone happy with this giveaway.
The main prize of this giveaway is 1000
How can you get them? Here are the rules:
1. You need to be my watcher.
2. You need to fave this journal (You'll get a number, which I will use to determine the winner, via http://www.random.org/ )
3. You need to link this giveaway in your journal
4. You need to comment here, and insert the link to your journal, containing info of this giveaway.
That's all
The deadline for this giveaway is
27st of September
Good luck
[OPEN] Adopt Raffle 09 - Memories
Waaah such a long time we didn't make a raffle >///v///<
We really love doing that so this time we try with our new project "Memories" , Little Owl/penguin ( x°D )
We hope you like them \;///v///;/ thanks again for the support
What can you win?
One adoptables at your choice between those shown , they are a species called "Memories" they are little pet/character like a owl(or penguin x°D at your choice x°D ) , they write people's memories , they never forget about you
Only one winners , after raffles end the 7 adoptables left will be put for sale ;v;
Required to win
Fav this Journal
Watch it's not necessary to win , but really appreciated it if you like our works enough to wish one of them ;//////v/////; <3 ( thanks ;v; )
You don't have to ask if you can partecipate , just fav this journal an
7 tips for the 21 year old me
7 TIPS FOR THE 21-YEAR-OLD ME by Bobby Chiu
When I was a student in college working on my skills as a character designer, I'd had periods where I would sit at my desk working as hard as I could but having little to show for my efforts at the end of the day. I remember sitting there surrounded by blank pieces of paper, trying to come up with an amazing style that nobody had ever seen before. I would do one drawing and not be satisfied, so I would lay a new piece of paper over it, re-draw it with slight changes to features here and there. This would still not be good enough so I would put another piece of paper over my revision, make more minor adjustments trying to perfect this new style I was searching for.
I did this for weeks on end, tweaking and polishing over and over, working hard every day. But in the end, did I come up with a brand new style, something amazing that
1500 Points Raffle Giveaway[OPEN]I decided to do this giveaway because I have some spare points and I wanted to help other deviants.
To enter:
Fav this journal (1 entry)
This will be your number ( I'll choose the winners with Random.org.)
Make a journal/pool about this giveaway (2 entries)
If you want to increase your chances of winning
donate 5 : 5 more entries
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donate 20 : 45
2500 Point Giveaway [OPEN] #5
Hi guys!
Just for anyone interested and/or that is really needed points, simply follow info.
*and if you want help, please contribute a small or big donation, would be a great value! ♥
Enter in my profile page: ~~Help-donate-points~~
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Your character in Missing Halloween! (RESULTS)MISSING HALLOWEEN
In August 21, "Your character in Missing Halloween!" mini-contest was announce.
In September 1, a total of 313 character designs were submitted. Judging has begun.
As the judge, there were 313 submissions, and only 32 to choose from. Trust me, it was haaaarrd! It still pains me that so many great designs didn't get in. (It's just that many) But I still did my best to judge them carefully.
So here goes, the results!!!
As mentioned, there will be 5 characters who will be featured as candy givers! (And their owners to be in the credits as "Additional Character Design")
And here they are!!!
:iconAndrea4You: Andrea4You's character: Akai
:iconSkunkyfly: Skunkyfly's character: Amber
:iconShiroXIX: ShiroXIX's character: Pydur
:iconinkstainkat15: :d
Nsio's Four Tools for a Successful DrawingNsio's Four Tools for a Successful Drawing
Let's face it, drawing is hard. Especially for a beginner, learning to draw seem dauntingly challenging. Even more experienced artists have it hard and I'm not anyway different from that. At the same time, weirdly enough, drawing is surprisingly simple and straightforward thing to do. But that's when you know what you are doing.
In fact, drawing is probably hard for you just because you don't know how it's done. And if you ask an artist how it's done, you will likely get rather vague answer. They know how to do it, but they don't know how to explain it for you. Drawing is full of concepts that simply don't translate well for an average Joe. Also, even if a great artists gives you a tip how to draw something, you probably still have troubles at executing it. You just don't see things the way the artist does., so you might even end up using the tip wrong, but believing in it so hard that you can't correct yourself. Not to mention the actu
RAFFLE - TWO WINNERS.Hello~ /O/
First, sorry for the inactivity. _(:'3_
I haven't been at my house these months and I had trouble getting internet.
But now I'm back and I hope that everything returns to normal.
So I wanted to make a raffle to celebrate it. xD
- Only watchers. u/v/u
- Fav this journal to get a number.
- Make a new journal entry linking to this raffle or make a poll about it!
- Leave a comment here linking me to your journal entry/poll.
THE RAFFLE ENDS SEPTEMBER 20th.
Winners will be selected with ramdon.org.
Thigh-up or Chibi.
halloween art exchange! since the holidays are coming up slowly but surely, and since a lot of exchange groups/ secret santas only
accept "high quality art" or "only digital" and etc....
i decided to do an exchange, and all art levels, mediums, and styles are accepted!
and the theme of course is HALLOWEEN!
how to enter (all steps are necessary)
1. add this journal to your favorites, and if you want you can spread the word out with a journal or poll~!
2. add secret-exchange-2014 to your watchlist and join the group for updates on when you will be able to make your wishlist, and to submit your exchange gift!
3. fill out this form in the comments section of this journal:
username: *insert your username here*
are you a digital, traditional, or mixed (you can do both) artist? :
what skill
Vacation!Leaving in a couple of hours for my vacation in Croatia! So I'll be gone for about 2 weeks, thus will likely not comment on anything during this time. I'll have my tablet with me, but I don't know how much wifi I'll have available.
See you all in 2 weeks, and I look forward to a couple hundred updates when I get back, lol!
The TrundlerThe waste land behind the fire station is always silent. No birds sing there, and even the wild rabbits and feral cats avoid it. Weedy wildflowers nod their seasonal heads in the breeze. Lying fallow in the midst of housing developments, shopping malls, the new movie theater — the vacant lot stands out like a knife wound on a woman's placid face, shocking, brazen, ugly.
It is always empty. Except for one thing: a ragged heap of old trash, all nasty black tar paper and vicious snarls of rusted wire, car parts and broken glass and other junkyard jetsam. The embodiment of injury waiting to happen, an invitation to a tetanus shot... the city never hauled it away. No one ever wants anywhere near it; it radiates an eerie sense of calculating watchfulness.
And at night, it wanders.
When darkness falls, and the last cars heading into the hives of tract housing stop illuminating the asphalt with moving-picture shadows, it… unfolds. Bitter, broken tangles, grotesquely mov
Inspector Wolf The old lady was dead. I could smell it before I even got into the house. The whole place reeked of adrenaline, sweat, fear, copper and steel. He'd dropped her right in her living room. Chopped and chopped until she stopped moving. But I could tell I was getting close. This had been done in a hurry, and the killer didn't have the time to clean up after himself like he usually did.
Across the room, the phone rang. The shrill sound set my teeth to grinding, but I ignored it. Instead I followed the killer's bloody footprints into the back bedroom. He'd climbed out the window. If I hurried, I could catch up to him and end this disgusting spree he was on.
Then the answering machine kicked in. "Hi, Gramma! It's Red. Sorry I'm running late. I kind of lost track of time. But don't worry. I packed the picnic and I'm heading out the door right now. Love you."
She'd been expec
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scheinbar is a much-loved and well-known deviant. Just one look at her gallery, filled with enchanting photography, will have you mesmerized. A deviant for over 7 years, Christiane can always be found posting inspirational features as well as regularly commenting on other deviations and encouraging and empowering her fellow deviants. We are inspired and insist that you too stop by and congratulate ... Read More
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Osteoarthritis is the most common form of arthritis, affecting millions of people around the world. Often called wear-and-tear arthritis, osteoarthritis occurs when the protective cartilage on the ends of your bones wears down over time.
While osteoarthritis can damage any joint in your body, the disorder most commonly affects joints in your hands, neck, lower back, knees and hips.
Osteoarthritis gradually worsens with time, and no cure exists. But osteoarthritis treatments can slow the progression of the disease, relieve pain and improve joint function.
Osteoarthritis symptoms often develop slowly and worsen over time. Signs and symptoms of osteoarthritis include:
If you have joint pain or stiffness that lasts for more than a few weeks, make an appointment with your doctor.
Factors that increase your risk of osteoarthritis include:
Osteoarthritis is a degenerative disease that worsens over time. Joint pain and stiffness may become severe enough to make daily tasks difficult. Some people are no longer able to work. When joint pain is this severe, doctors may suggest joint replacement surgery.
While you may initially bring your concerns to your family doctor, he or she may refer you to a doctor who specializes in joint disorders (rheumatologist) or orthopedic surgery.
You may want to write a list that includes:
Your doctor may ask some of the following questions:
During the physical exam, your doctor will closely examine your affected joint, checking for tenderness, swelling or redness. He or she will also check the joint's range of motion. Your doctor may also recommend imaging and lab tests.
Pictures of the affected joint can be obtained during imaging tests. Examples include:
Analyzing your blood or joint fluid can help pinpoint the diagnosis.
There's no known cure for osteoarthritis, but treatments can help to reduce pain and maintain joint movement.
Osteoarthritis symptoms can be relieved by a variety of medications, including:
A combination approach to treatment often works best. Your doctor may suggest:
If conservative treatments don't help, you may want to consider procedures such as:
Lifestyle changes and home treatments also can help reduce osteoarthritis symptoms. You might want to try some of the following tips:
People who aren't helped by medications for osteoarthritis pain sometimes turn to complementary and alternative medicine practices for relief. Common treatments that have shown some promise for osteoarthritis include:
Medications and other treatments are key to managing pain and disability, but another major component to treatment is your own outlook on life. Your ability to cope despite pain and disability caused by osteoarthritis often determines how much of an impact osteoarthritis will have on your everyday life. Talk to your doctor if you're feeling frustrated. He or she may have ideas about how to cope or refer you to someone who can help.
Original article: http://www.mayoclinic.org/diseases-conditions/osteoarthritis/basics/preparing-for-your-appointment/CON-20014749
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Willa Mae Odom Cato was born to loving parents, Rev. Willie Odom and Carrie Theus Odom in Minden on Oct. 1, 1929. She was welcomed by her older brother, W.D. Odom.
She began piano lessons from Mr. Emerson at the age of three. Her family did not own a piano, so she drew the keys on a formica table top and diligently practiced; imagining the music as she touched the hand-drawn keys.Subscribe to Read!


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Dark red paved stone border earrings
Item No.0600108947
From Martine Wester, these small dark red stone earrings are detailed with paved silver stones to the outer border and have a stud fastening.
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Bath Accessories
Bath Accessories
You probably spend more time in your bath than you realize – so it deserves to have the most up-to-date accessories. Experts say that updating or remodeling a bathroom is one of the best ways to add value to your home. And that means not overlooking things like tissue paper holders and towel bars.
The collections we carry cover everything from decorative hooks and bathroom shelves to mirrors and vanities. Revitalize your space by updating these important elements and you'll see immediate results for your effort
We carry complete collections from the top brands, or you can mix-and-match to complement your décor. Our quality finishes include oil rubbed bronze, satin nickel, polished brass and many more.
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Rusticware Riverside Oil Rubbed Bronze Standard TissueSKU# : RW-8108-ORBMSRP$37.50Discount Price$31.88
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It was nine years ago this month when a far-fetched dream of mine became reality as I squeezed the trigger on a Merriam's gobbler in the Badlands of South Dakota.
The 21 pound gobbler completed my quest for a coveted Grand Slam. The fans of an Eastern, Rio Grande, Osceola and Merriam's along with a plaque from the National Wild Turkey Federation commemorating the event grace my office wall.Subscribe to Read!


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Argosy University offers a variety of degree programs in flexible learning formats including blended or campus learning.
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Bausch and Lomb Advanced Eye Relief Rejuvenation Eye Drop (1 fl. oz.)


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Earn 1 hr. CLE/1 hr. Ethics | Video Replay | Bring a sack lunch
ISBA members can take this course for free to obtain the 3 hours of Ethics credit included in your ISBA member benefits. Once you have accumulated 3 hours of free Ethics credit, the usual ISBA member rate applies. Please note: Registration is required.
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The Wonderful World of Color
- Details
- Created on June 18, 2013
- Written by Kim Groseclose
The color forecast for 2013-2014 is out, and once again is a reflection of our ever-changing times. For example, Emerald Green has been declared the top color for 2013 by Pantone. A color that has long represented newness and growth, green represents moving forward in the difficult economic times we live in. A quick look around any furniture or home goods store in 2013 will most likely turn up a host of accessories and home décor items done in shades of emerald. That said, blue has also been predicted to be a major player in the world of color for 2013-2014. Again, difficult times make the soothing hues of blue attractive to consumers.
2013 PDRA Scholarship Awarded at Las Vegas Show
- Details
- Created on May 21, 2013
- Written by Kim Groseclose
This year's PDRA Scholarship was awarded to Christina Haberny of Little Falls, New Jersey after being sponsored by member Bernard Rossi, owner of Rossi Decorating Center Of Little Falls. Rossi nominated Christina for the $5000 award, which is very generously sponsored by the National Hardware Show®.
Modest Gains for Independents in First Quarter 2013
- Details
- Created on April 30, 2013
- Written by Kim Groseclose
Paint and decorating stores posted modest gains overall for the first quarter of 2013 over the first quarter of the previous year. Not all regions fared well, however, with the Midwest posting losses of 5.9% from the first quarter of 2012. Canadian paint and decorating retailers also posted a loss compared to last year's first quarter figures.
On a positive note, the Consumer Confidence index has been above 50 since November of 2011, settling back to just below 60 in March of 3013. New home starts have been showing solid growth trends from a low 18 months ago of 600,000 units to just over 1,000,000 units.
Excitement Builds as PDRA Paint & Accessories Show Nears
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- Created on April 24, 2013
- Written by PDRA
This year's PDRA sponsored Paint & Accessories Show at the 2013 National Hardware Show® is fast approaching with its return May 7-9 at the Las Vegas Convention Center in Las Vegas, Nevada.
The most comprehensive single-largest buying opportunity in the U.S. for the independent paint dealer makes this a "must attend" event! It is shaping up to be an exciting and informative showcase for the industry's top brands and trends, where over 250 manufacturers plan to display their wares in many new and expanded categories.
Join the PDRA in the Central Hall Lobby on the Main Stage with the National Hardware Show® and the NRHA – National American Retail Hardware Association for the Grand Opening Ceremony of the 68th National Hardware Show® and All-Industry Conference May 7th, 8:45 a.m. – 9:00 a.m.


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US: Cott secures credit facility
Cott Corporation has completed a new senior secured global credit facility jointly led by Wachovia Capital Markets, LLC and BMO Nesbitt Burns, and an asset securitization facility with JPMorgan Chase Bank, N.A.
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If you've ever been unable to stop yourself from eating too many Oreo cookies it may not be your fault--a new college study says one of America's favorite desserts is just as addictive as drugs in lab rats.
The study by students at Connecticut College found that when the rats ate Oreos they formed an equally strong association with the cookies as when other rats were injected with cocaine or morphine.
Additionally, researchers found eating the cookies activated even more neurons in the rats' brain "pleasure centers" than the addictive drugs.
"Our research supports the theory that high-fat/ high-sugar foods stimulate the brain in the same way that drugs do," Neuroscience Professor Joseph Schroeder said in a school press release. "It may explain why some people can't resist these foods despite the fact that they know they are bad for them."
The student behind the study says she wanted to explore how foods with high fat and sugar content contribute to obesity in low-income communities, and that the results are troubling.
"Even though we associate significant health hazards in taking drugs like cocaine and morphine, high-fat/ high-sugar foods may present even more of a danger because of their accessibility and affordability," Jamie Honohun said.
On a lighter note, Honohun says they also got a surprise when watching the rats eat the Oreos.
"They would break it open and eat the middle first," she said.
Original Report: http://www.foxnews.com/health/2013/10/15/college-study-finds-oreo-cookies-are-as-addictive-as-drugs/?intcmp=features
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The three-day Electric Zoo music festival on Randall's Island was unexpectedly cut short after two people died.
Sunday was supposed to be the last day of the Electric Zoo Music Festival but after the two drug deaths and others got so sick they're in critical condition, the plug was pulled.
20-year-old Olivia Rotundo from Providence, RI was one of thousands who attended the weekend music festival that featured electronic music acts, but Saturday night the University of New Hampshire student was pronounced dead after being rushed to Metropolitan Hospital.
Police say 23-year-old Jeffrey Russ of Rochester, who graduated last year from Syracuse University, died early Sunday morning.
City officials say both deaths appear to be related to the drug "molly'—a supposedly pure form of ecstasy or MDMA.
"You've got a big problem if you're taking this drug on a hot day, you're going to become dehydrated, your heart is going to start racing. You may have convulsions, you may have a heart attack and you may get a stroke," said Dr. Steven Garner, Emergency Medicine Specialist at Methodist Hospital.
Festival promoters extended condolence to the victims' families on their website. City officials say at least four other people are critically ill and in intensive care from suspected drug overdoses. But it's difficult to know how many concert goers became ill and needed medical attention.
The promoters used a private ambulance service that bypasses the 911 reporting system. Dr. Garner says many users mistakenly think if the drug is pure, it won't do damage.
"There is no safety level for casual users. Those who are taking it are running the risk of having dementia, brain problems, depression later on in life because this alters the normal structure of the brain – there's no doubt about it."
The NYPD says more than 30 people were arrested, mostly on drug related charges.
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Family tobogganing (Canadian Tourism Commission photo)
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What if Edward loved someone when he was human? Her name is Marie, but on the morning of their wedding, Edward disappeared. The reason? He was bitten by a vampire. The sad thing is, Marie was left in the church,
and pitied by everyone because everybody thought her own groom ran away from
her. Now, Marie was broken-hearted. She does not know what to do with her life
Edward. And she believed them, she believed that her love really left her.
After several months, she disappears too and was never heard of again. When
heard this, as a vampire ofcourse, he searched for ways to kill himself, but Carlisle found him and as all of you know, the Cullen
family started. But Edward yearned for his Marie, and pledged never to love
someone else except Marie.
Chapter 1 is on page 5..link doesn't work sorry.
Chapter 2 http://www.thetwilightsaga.com/forum/topics/anonymous-1?groupUrl=fa...Chapter 3 is on page 19..link doesn't work sorry.
Please COMMENT
But please don't if you're just going to criticize.
you have to add the updater if you want updates.
the first banner was done by me, I used www.fotoflexer.com lol
the banners here are done by mrs.sky cullen, ash blackwood-strigoi, celia, myself(lol) and kelsi anne. Thanks for spending time creating them and they're all very beautiful!
and I should warn you, if you don't know yet, I am a master of giving cliffhangers. and twists.Never try reading at night..okay? lol.
Please try reading my other fanfics?
*Golden Eyes-What if Carlisle was Bella's father?
this story's begginign chapters suck. really really suck. There are ohso many grmmar errors, but what can I do? I started writing this since I was 11. Now I'm 13. Maybe I might edit it all. I don't know, but the chapters gets good once you read until the middle.
*Love's Wounds-Bella loves another vampire, a vampire who broke her heart in Phoenix, and when in Forks, she knows EXACTLY what the Cullens are. And she hates
them.Who wouldn't? Vampires are all liars..right?
head writer: Ѽlittlemisswriter-rexanne♥
editor: julia cullen
fashion designer: annabeth chase
Views: 763
© 2014 Created by Hachette Book Group.
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WinCraft Die-Cut D.C. United MagnetItem Number: 17961956
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Display your team spirit with this WinCraft® Die-Cut D.C. United Magnet. Featuring a team logo, there will be no doubt where your allegiance lies. Made of heavy duty material, this magnet is the perfect way to stick on your team pride. Root for your favorite team with this Wincraft® Die-Cut D.C. United Magnet.
- Die-cut magnet
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Wild Friends - All Natural Almond Butter Vanilla Espresso - 16 oz. (454 g)Wild Friends All Natural Almond Butter Vanilla Espresso is your morning cup of coffee: now in almond butter form. When they first started their company in college, they decided to try swirling their freshly roasted almond butter with espresso and pure vanilla. Ever since, this wild combination has been the perfect 'morning blend.' Enjoy!
Frequently Asked QuestionsDo their nut butters have to be refrigerated?That is a great question. The answer? It's up to you! Nut butters technically do not need to be refrigerated. The reason it is often recommended is to prevent oil separation. They have a lot of customers who prefer their nut butters refrigerated, especially after they have been sent in the mail. If you live somewhere where it is hot, the nut butters can arrive thinner than you would like. Putting them in the fridge and giving them a good stir produces a thicker texture and stronger flavor. Do what feels right to you and your nut butter spreading needs.
What is the shelf life on their nut butters?Their peanut butter is good for a year sealed on shelf. Once opened, they recommend eating within 3 months of being opened if stored on the shelf or within 6 months if kept in the fridge.
Where did their chocolate espresso peanut butter (Bright Eyed and Bushy Tailed flavor?They will no longer be making their Bright Eyed and Bushy Tailed flavor. When they were experimenting with almond butters, they decided that the coffee flavor was even better with almonds! So for those of you who were loyal Bright Eyed and Bushy Tailed fans, they encourage you to try their new Vanilla Espresso Almond Butter.
Does their nut butter have sugar in it?They prefer to use less processed versions of sugar in their nuts butters. In their Honey Pretzel Peanut Butter, they use high quality clover honey as a sweetener, while their other four flavors are sweetened only with agave nectar. For more info on these ingredients, check out their ingredients page!
What's the most delicious way to eat their nut butters?They're so glad you asked! They have tons of ideas. They suggest spreading it on your morning toast or bagel, stirring it into a hot bowl of oatmeal, with your fruit or celery sticks, on top of your morning pancakes/waffles, baked into brownies or cookies, as a frosting for yummy baked goods, in a smoothie, milkshake or ice cream, and their favorite…with a spoon! For recipes using their nut butters, check out their recipe page.
Are their products Dairy-Free? Vegan?All of their products are dairy free. Besides Honey Pretzel, which has honey, all their other 5 flavors are vegan.
Are their products gluten free?Their only flavor that contains an ingredient with gluten is their Honey Pretzel, which has bits of pretzels swirled into it! That being said, their facility is not gluten free certified, so they do not recommend consuming their nut butters if you are acutely allergic to gluten
WILD FLAVORS: Their wild flavors are unique and delicious, without confusing or misleading nutrition facts. They are naturally and minimally sweetened to create flavors that please the palate, while keeping a clean nutrition profile to fuel your body and mind.
AGAVEAgave nectar or syrup is a natural sweetener that has a flavor similar to honey, made from the natural juices of the agave plant. Unlike cane sugar, agave has a low-glycemic index, meaning agave does not cause a sharp spike in blood sugar levels after consumption. Another benefit to using agave is that it is generally around 1.5 times sweeter than sugar, which means they can use less and still achieve optimal sweetness.
ALMONDSRich in fiber, protein, healthy fats, potassium, calcium, iron and antioxidants, almonds are said to have the most nutrients out of any other nut! These perfectly sweet and savory nuts are a healthy addition to any diet, as they help to regulate cholesterol and blood pressure, improve brain function, boost energy levels, control weight and prevent cancer. What's not to love?
CHOCOLATEThe world would be a far less enjoyable place without the existence of chocolate! Deeply rooted in Aztec and Mayan culture, chocolate was first enjoyed by mixing ground cacao seeds with a variety of spices to make a frothy drink. Eventually, these cacao seeds were discovered by the Spanish conquistadors, who brought them back to Europe. Over time, new recipes and technologies were created to transform the cacao seeds into the many varieties of chocolate they love today. They are committed to using only dairy free, unsweetened dark chocolate. Dairy-free dark chocolate allows those with dairy intolerances the freedom to enjoy their nut butters as well as creating a richer flavor overall.
CINNAMONPrized for its bold aromatic flavor and versatility in both cooking and medicinal purpose, cinnamon is one of the oldest spices known to man. Available in either stick form or as a ground powder, cinnamon comes from the inner brown bark of cinnamon trees grown primarily in Southeast Asia. Cinnamon has unique healing abilities that are rooted in three essential oils found in the bark. These oils are highly nutritious and contain anti-inflammatory properties while helping to regulate blood sugar levels, boost brain function, improve colon health, and prevent heart disease.
COCONUTCoconut is the seed of a tropical palm that has been highly valued for thousands of years as both food and medicine, earning the name "The Tree of Life." Coconut is highly nutritious and offers incredible health benefits. It is rich in fiber, vitamins minerals and is a very good source of healthy saturated fat. Unlike other sources of saturated fat, coconut is a medium chain saturated fat, meaning human bodies utilize it more efficiently as it converts into energy rather than stored fat. Coconut is found to lower cholesterol and protect against heart disease while also improving digestion, reducing inflammation and increasing metabolic rate.
COFFEEWith flavor as rich as its history, coffee is one of the most universally known crops in the world today. Coffee beans come from the berries of coffee plants that are grown in tropical regions close to the equator. Coffee is highly prized for its distinctive characteristics such as flavor, caffeine content, acidity and body, which reflect the growing region. Coffee is not only beneficial as an energy booster, it can also provide surprisingly positive health benefits. The coffee bean is filled with anti-cancer properties and antioxidants that are thought to protect against common cancers, it can lower blood sugar, fight type 2 diabetes, and even regulate high blood pressure. They use coffee beans in their Vanilla Espresso almond butter.
HONEYHoney is known as a miracle food for many reasons! Number one - it never goes bad. Number two - it is the only food eaten by man that is produced by insects. Number three - honey is the only food that is known to contain all substances necessary to sustain life: enzymes, vitamins, minerals, and water. That being said, not all honey is created equally. Today, there are many commercially produced honeys that are overly treated and filtered with improper balances in sugar and water. This industrial processing causes honey to lose its incredible health benefits. High quality minimally processed honey, like they use in their peanut butter, keeps all the nutrition! Honey is a natural energy booster, and its antioxidant and anti-bacterial properties boost immunity and improve digestion. Also, honey has been used throughout history as a natural home remedy to cure everything from burns to arthritis pain.
PEANUTSSaid to be first cultivated in the valleys of Peru, the peanut is not actually a nut, but rather a part of the legume, or bean, family. Peanuts have also been known as earth nuts or ground nuts because after its flower has been pollinated, the weight of the plant bends it until it touches the ground. Further growth pushes it underground where the fruit develops into a pod, which they know as the peanut! Peanuts are rich in many nutrients, providing over 30 essential nutrients and phytonutrients, including niacin, folate, fiber, magnesium and vitamin E. Peanuts are naturally rich in antioxidants, free of trans-fat and sodium, and they contain about 25% more protein then any other nut!
PRETZELSThese crunchy, salty sticks that are known today as a classic American snack have their origins in the state of Pennsylvania. Many stories have been told about the origin of the hard pretzel. But the most commonly told version concerns an apprentice baker who fell asleep while baking soft pretzels. Thinking the pretzels had not been baked long enough, he turned the oven temperature higher and cooked them twice as long as intended. One of the best mistakes in history! Pretzels are free of trans fat and have fewer calories then many products in the snack aisle. They only use the right amount of pretzels to get all the crunchy goodness without adding too many extra calories! Their motto: everything can be enjoyed in moderation!
RAISINSThese plump juicy little dried fruits hold a special place in their heart. They were the first ingredients that they added after making their first batch of homemade peanut butter in their college apartment. They are also the reason Sneaky Cinnamon exists today! Raisins, which of course are dried grapes, are produced and enjoyed all over the world. They are highly versatile, you can enjoy them raw, or you can cook and bake them in your favorite recipes. Raisins are high in antioxidants, provide a high dose of fiber, and are rich in natural sugars for a healthy energy boost! These super fruits have an incredible list of other health benefits: they support healthy digestion, improve eyesight, fight bacteria that cause cavities and gum disease, and much more.
SUNFLOWER SEEDSAs one of the first plants to ever be cultivated in the United States, the sunflower is deeply rooted in people's agriculture and diet. Their seeds have been cultivated for thousands of years and were part of the Native American diet long before staple crops like corn, squash and beans. This plant loves the sun so much, it retains all of the sun's nutrients and even takes its appearance! They have an incredible amount of Vitamin E which aids in neutralizing free radicals, magnesium which supports bone health, and selenium which is strongly correlated with cancer prevention.
VANILLAPure vanilla is the second most popular spice in the world next to saffron, and for good reason. With its unique sweet n' spicy yet delicate flavor, vanilla is an ingredient unlike any other! Vanilla comes from the fruit of a thick green orchid vine that grows wild on the edge of rainforests found primarily in Mexico and Madagascar. The long green pods are picked before they're ripe, and undergo a fermentation process that lasts up to 6 months. The result: rich, brown, aromatic vanilla beans! They use vanilla in the form of powder, which is produced by grinding whole dried vanilla beans into a powdery substance. Vanilla adds rich flavor and nutrients to any food. It contains B vitamins that help in enzyme creation, nervous system function, and body metabolism regulation. It also contains minerals such as calcium, magnesium, potassium and iron. So much power inside that little pod!
DRIED CRANBERRIESKnown for their jewel toned hue and tangy flavor; dried cranberries are the 2nd most popular dried fruit after raisins. The antioxidants and Vitamin E in dried cranberries help reduce inflammation, cutting the risk of chronic health problems, such as heart disease and cancer. A serving of dried cranberries also contains iron, potassium, and vitamin C.
SESAME SEEDSThese deliciously crunchy and nutty little seeds are one of the first seeds known to man! Sesame seeds are rich in mono-unsaturated fatty acid oleic acid, which lowers LDL ("bad cholesterol") and increases HDL ("good cholesterol") in the blood. Sesame seeds are also rich in protein and several essential vitamins and minerals such as B-vitamins, calcium, magnesium, iron, and zinc.
Mission Statement:
About Wild FriendsWild Friends began by happy accident one dreary Sunday at the University of Oregon. The two of them were in their college apartment, scraping the bottom of yet another jar of peanut butter. With no more peanut butter and a surplus of celery, they were faced with a familiar conundrum. However, neither of us wanted to ride a bike out in the pouring rain to buy more.
Luckily, they had a bag of raw peanuts, a brand new food processor, and two squirrelly little minds. It didn't take long before they had created their first batch of homemade peanut butter. However, as creative chefs, they were not content with leaving their freshly made peanut butter to be just plain or crunchy. So they began adding every conceivable ingredient from their pantry. They sprinkled in cinnamon, raisins, chocolate chips, coffee, coconut...the list went on and on.
After extensive sampling, they decided their product was simply too good to keep to theirselves, so they brought a few jars over to their friends. They loved it, and encouraged us to make a website to sell their tasty creations.
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Yeah, a good blender helps! I was using a crappy one for a while and I basically had to chew my smoothies. bleah.
I did find that using the stiffer lacinato kale helped it get chopped up a lot better than when I used the softer, more lettucey kales like red russian.


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PayPal + Samsung
Stepping Up
Great article by @kevinmccull about the design thinking trend, its promise and failures, and requirements for design leadership success in business environments.
For all its failings, Design Thinking uncovered real opportunities for design managers aiming to play a more strategic role in business. The problem stemmed from a naive combination of overreach and a lack of ambition to learn.
Things I Have Learned
Original post on Medium.
So I have two kids ages 2.5 & 4, lead a team of designers at Google, and have practiced design for many years now. What do I know? The following is a short collection of things learned during the course of my life. The contents of this list will change and grow, I hope, as life progresses.
- Be concise. Say more with less.
- Learn from your mistakes. The only failure is to make the same mistake twice.
- Be authentic. If you feel fake, it's because you don't trust yourself.
- Find a mentor. Find someone better than you, who you admire. Observe them in context, ask questions, do what they say, then question them.
- Be a mentor. Through the process of advising others you will codify your practice.
- Be humble and appreciative. Let your actions speak louder than words. Otherwise, you'll be defined as a braggart. Not an effective leadership technique.
- Be open to learning. The minute you stop learning, you grow crufty, old and outdated. Not good in tech.
- Challenge yourself. Related to learning. Put yourself in new situations that require you to swim.
- Make decisions. Seems obvious. Too many people let others decide for them.
- Empathize. Think about the world from the perspective of those around you. Read Jung. Understand archetypes. You will develop a sixth sense.
- Network. It's easy, and it pays off. If you too are shy, get over it.
- Collaborate. Power in numbers. But be sure to pick your team wisely.
- Set goals. Three months, one year, five years, and retirement. Even when the horizon is too far to realistically visualize, you will at least define a path.
The Thumb Zone
A year old article, but timelessly relevant.
In the past year or so, there have been many discussions about how users hold their mobile devices—most notably Josh Clark's. [2] But I suspect that some of what we've been reading may not be on track. First, we see a lot of assumptions—for example, that all people hold mobile devices with one hand because they're the right size for that—well, at least the iPhone is. [3] Many of these discussions have assumed that people are all the same and do not adapt to different situations, which is not my experience in any area involving real people—much less with the unexpected ways in which people use mobile devices. - See more at: http://www.uxmatters.com/mt/archives/2013/02/how-do-users-really-hold-mobile-devices.php?#sthash.reeG2OpD.dpuf
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Practice Empathy
Useful article by Chad Fowler on the power and practice of empathy. Great read for designers working with clients, cross-functional teams of Product Managers and Engineers, etc.


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TURIN (Reuters) - Fiat
The scheme will kick off on February 11 and last until the end of 2014. It will allow the company to stop one line at a time out of two at the plant, Fiat said.
Melfi, one of Fiat's most important facilities in Italy, currently manufactures the Punto model.
Back in December, Fiat said it will invest 1 billion euros ($1.3 billion) to produce a new Jeep and a new Fiat 500 in Melfi, southern Italy, from 2014.
Like other car makers, Fiat, which controls U.S. carmaker Chrysler, has been hard hit by Europe's debt crisis. Last year car sales in Italy slumped to their lowest level since 1979.
Government spending cuts and high unemployment have hit consumer budgets and sent demand for cars plunging in an industry that suffers from overcapacity.
(Reporting By Gianni Montani)


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Austin Keough throws complete game victory
NATCHITOCHES — The Minden Crimson Tide scored three runs in the top of the third inning and then held on for a 3-1 win over Natchitoches-Central (NC) on Thursday.
Austin Keough pitched an outstanding game, taking the win for the Tide. He threw a seven-inning complete game allowing just three hits and one earned run while striking out six.Subscribe to Read!


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If I owned a chainsaw, this is the only way I would ever want to open a beer. When I read the caption for this video, I thought for sure that it was just going to be some idiot running a chainsaw through the glass top of the bottle... possibly ending in a complete disaster.
THIS ... this is much more impressive.
Nice party trick! Although, unless you are a real pro with one of these bad boys, I would have to advise you not to try this at home.
Now, off to find me one of them Angry Orchard beers I love so much.


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Justin Bieber's Believe drops
Justin Bieber released his record Believe on Tuesday, which was immediately followed by an outbreak of Bieber fever. No one was safe, including Manhattan borough president Scott M. Stringer, who announced that Tuesday was to be known as "Justin Bieber Appreciation Day." The ladies of The View and their teenage audience became faint when Biebs performed, and even Jimmy Fallon hallucinated a bit. Just in case you haven't been infected, here's the Biebs performing "Boyfriend" on The View.
Ryan Gosling sweats till he bleeds
Ermahgerd … Ryan Gosling in hammer pants thrusting his 10-year-old pelvis out to C + C Music Factory's "Gonna Make You Sweat (Everybody Dance Now)" … with his sister. Enjoy.


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7 U.S. Code § 4610a - Investigations and power to subpoena
(a) In general
The Secretary may make such investigations as the Secretary determines necessary—
(b) Power to subpoena
(1) Investigations
For the purpose of an investigation made under subsection (a) of this section, the Secretary is authorized to administer oaths and affirmations and to issue a subpoena to require the production of any records that are relevant to the inquiry. The production of any such records may be required from any place in the United States.
(2) Administrative hearings
For the purpose of an administrative hearing held under section 4609 or 4610 of this title, the presiding officer is authorized to administer oaths and affirmations, subpoena witnesses, compel their attendance, take evidence, and require the production of any records that are relevant to the inquiry. Such attendance of witnesses and the production of any such records may be required from any place in the United States.
(c) Aid of courts
In case of contumacy by, or refusal to obey a subpoena issued to, any person, the Secretary may invoke the aid of any court of the United States within the jurisdiction of which such investigation or proceeding is carried on, or where such person resides or carries on business, in order to enforce a subpoena issued by the Secretary under subsection (b) of this section. The court may issue an order requiring such person to comply with such a subpoena.
(d) Contempt
Any failure to obey such order of the court may be punished by such court as a contempt thereof.
(e) Process
Process in any such case may be served in the judicial district in which such person resides or conducts business or wherever such person may be found.
Source(Pub. L. 98–590, § 11A, as added Pub. L. 101–624, title XIX, § 1986,Nov. 28, 1990, 104 Stat. 3908; amended Pub. L. 102–237, title VIII, § 807(2),Dec. 13, 1991, 105 Stat. 1883.)
1991—Subsec. (b)(2). Pub. L. 102–237struck out "section" after "4609 or".
The table below lists the classification updates, since Jan. 3, 2012, for this section. Updates to a broader range of sections may be found at the update page for containing chapter, title, etc.
The most recent Classification Table update that we have noticed was Tuesday, August 13, 2013
An empty table indicates that we see no relevant changes listed in the classification tables. If you suspect that our system may be missing something, please double-check with the Office of the Law Revision Counsel.
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Frank Dandy
W.Cloud Camo Boxer
Boxer briefs by FRANK DANDY. Wide elastic waistband with logo. Lined crotch. Machine wash 40 degrees.
Made of 95% Cotton and 5% Elastane.
Item no.: 111791-0029
Colour: Blue
Size reviewsSmall in size
More about the brandFrank Dandy is one of Scandinavia's leading underwear brands. They make underwear in fun prints created by illustrators and print designers. They focus on high quality design at an affordable price. Get your Frank Dandy underwear at Nelly.com.
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The Mukherjee cousins, Kajol, Tanisha and Rani Mukherjee are soon going to be neighbours. Kajol will see her cousin sister Rani as her neighbours soon as Rani's would-to-be sasural Aditya Chopra's father Yash Chopra's bungalow is at Juhu who is very close to Ajay Devgn's bungalow. Rani wi
Himesh, Tanisha & Armaan snapped at Bandra
tanisha mukherjee News
This time, it is not only rumours that are making rounds in B-town, but pictures, too, show 'Bigg Boss 7' lovebirds Tanishaa Mukerji and Armaan Kohli at a mall in Dubai recently. They were seen at some high-end stores, happily splurging. Tanishaa Mukherji and Armaan Kohli, who reportedly e
The weekend buzz around the tinsel town was that Armaan Kohli and Tanishaa Mukherjee are engaged. Following this, Armaan took his lady-love Tanishaa home to get her introduced to his parents on the occasion of Holi. If the rumours are to be believed, the couple is engaged and is likely to


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Ergonomic keyboard tray systems from all of the leading names in ergonomics. Featuring WorkRite Keyboard Trays and Humanscale Keyboard Trays.
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