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Best Buy Coupons
How to Use Best Buy Coupons
Best Buy offers many category specific coupons and promo codes from 25% off laptops and TVs to 10% off major appliances. You can often find a great deal with weekly and daily offers of up to 60% off original prices. Simply enter Best Buy in the Coupons.com search box and you'll see all available coupons and offers. Select the offer you want and go directly to bestbuy.com to redeem at checkout. For additional savings, you can visit a Best Buy near you to check out their open box and in store only offers for an awesome deal!
How to Save at Best Buy
Best Buy offers deals of the day, week, featured deals and an online outlet where you can save more than $300 on high-ticket items. Visit the site's refurbished section to save up to 45% on items that have been returned and restored to like-new condition. Be sure to join the my Best Buy Rewards program and Gamers Club to start earning points for future discounts and promotions.
Best Buy Free Shipping Policy
Best Buy offers free shipping on almost everything. You have the option to choose free in-store pickup to receive your order faster.
About Best Buy
Best Buy is one of the leading electronic stores in North America, Europe and China. A one-stop shop for all your electronics needs, Best Buy carries computers, cameras, games, mobile phones, TVs, appliances, videos and more.
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Save Up to 60% Off Deals of the Week
Plus Free Shipping
PlayStation 4 Console Available, Plus a Large Selection of Games and Accessories
Check Out this Week's Specials on Laptops and Packages Plus Free Shipping
Free Despicable Me Minion Trick or Treat Bag with Select DVD or Blu-ray Movie Purchase
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Plus $50 Gift Card when you Upgrade! In-store only.
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Persian Kittens!!! Purebred CFA papers, shots certificate, vet visits, deworming and "welcome kitty pac" all included 3 months old!Only 1 left!!! A blue-eyed white girl! Just delicious sweet purrfect healthy sweetpuff. Gorgeous coat and sweetest personalities...More info Email a friend
Sweet loving 2½month cute playful kitten needs a good home pet lovers only (305)993-8295More info Email a friend
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subset: commoncrawl


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Mizuno Kids' 9-Spike Franchise 7 Mid Baseball CleatItem Number: 23177426
Price: $39.99 $44.99*
You save: $5.00 (11%)
You save: $5.00 (11%)
Free Shipping Plus Free Returns on Footwear! (See Promotion Details)
Product Information
Customer Reviews
Buying Guide
Showcase your all-star skills in the 9-Spike® Franchise 7. A synthetic leather upper and padded tongue deliver unmatched lightweight durability and comfort while a full-length midsole keeps your foot locked in and ensures added cushioning. The Mizuno® 9-Spike® Franchise 7 baseball cleat has a 9-Spike® outsole with rubber stud layout that provides superior grip and acceleration to perform at the highest level on any field type.
- Synthetic leather upper and padded tongue offers maximum comfort and durability
- Full-length midsole offers top of the line padding for added comfort and a reduction of cleat pressure
- Mizuno® Wave® Technology combines stability and cushioning to provide the elements of a great running shoe in your cleats
- 9-Spike® Advanced outsole with strategically placed rubber cleats maximize baseballs running, throwing and hitting movements
- Previous Model: 9-Spike Franchise 6
- Weight: 7.15 oz
- Style: 320450
- Mizuno
Country of Origin: Vietnam


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Collection Visual Image Web Sites ArchiveShow Featured Items
McKissack and McKissack - Building to Bring Change
Official Web site of McKissack and McKissack, archived by the Library of Congress between March 30, 2006 and November 29, 2006 Web Site. electronic | Electronic (Form).
- Original Format: Archived Web Sites
- Date: 2006-03-30


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Photographers (General) in Harrogate
32 Wedderburn Close
North Yorkshire
Just off the A59 Harrogate to Knaresborough, approaching Starbeck.
Phone: 01423 8...
Opening Hours
10am - 2:30pm
Tuesday to Wednesday
10am - 5:30pm
10am - 7:30pm
10am - 4:30pm
10am - 2:30pm
Closed on public holidays
Similar nearby businesses
19 Wyvil Crescent, Ilkley, LS29 8ND
21 Chaucer Green, Harrogate, HG1 3LW
13 Oxford Street, Harrogate, HG1 1PY
59 Dragon Avenue, Harrogate, HG1 5DS
Crimple Head House, Harrogate, HG3 1QU
Valley Road, Harrogate, HG2 0JQ
Have a relaxed, fun filled session with your partner, friends or family. Special Summer Offer: FREE one hour session & 25% discount on wall products.
Let us make your special day complete with the best wedding photographs imaginable. Come along and see our wedding portfolio and let us listen to what you want. We will even give you a free engagement portrait session to show you just how good you'll look and feel.
Planning a special event or maybe even a charity function? We offer you an excellent event photography service with instant viewing and printing facilities. Great fun for you and your guests.
Award-winning personal friendly service tailored to your individual needs. Established since 1988 we have become one of the leading professional wedding, portrait & event photographers covering Yorkshire and beyond.
Numerous awards granted by the BIPP & MPA for wedding and event images.
Qualified Members of the MPA
Small pocket album with magnetic closure, contains 10 images.
Cash, MasterCard, Maestro, Visa, Direct Debit
You'll automatically qualify for a FREE pre wedding photo session when you book our Wedding Photography service for 2014/2015.
Terms: One FREE session per wedding booking. Booking must be made before 31 March 2015.
Expires: 31/03/2015
A huge thank you to both of you for producing a superb wedding album of our special day. Looking back we feel extremely lucky in picking you as our photographer. Your professional yet personable and enthusiastic approach is highly commendable. Most of all, we'd like to thank you for listening to what we wanted and for your eagerness to please. We truly appreciate the tremendous amount of time and effort you have dedicated to producing an amazing and unique wedding photo album for us. Your exacting standards and attention to detail are clearly reflected in the outstanding photos. All the photos are absolutely stunning. Every one of them has captured the special atmosphere of the day... sprinkled with the 'Horner' magic! The enhanced photos are simply out of this world! Each time we look through the album the photos bring back wonderful memories of our special day... which we'll be able to treasure forever... thanks to you. We would like to wish you every success in the future. It's no wonder that you were BIPP Yorkshire Wedding Photographer of the Year... may many more awards come your way to further recognise your unique skill and talent.
Testimonial on behalf of Hop & Jeremy
Testimonials are added by the business owner and are not independently verified.


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Posted by Web Staff - email | Facebook | Twitter
CLEVELAND, OH (WOIO) – Suspected serial killer Anthony Sowell is making an outrageous request in the Cleveland Strangler case.
Sowell wants a judge to tell prosecutors that even if he is convicted of murdering eleven women, they can't seek the death penalty.
Anthony Sowell is accused of murdering eleven women at his Imperial Avenue home and attacking several others.
Sowell and his defense team argue that death sentences get carried out in different ways all over the country and other serial killers have plead guilty and received life in prison.
Sowell is still trying to build his argument by asking how many other local death penalty cases have ended with life in prison pleas and how many death cases were later reversed.
Cuyahoga County prosecutors say this issue has been addressed before and "we are moving forward to trial in February and will try it as a death penalty case."
Sowell is already asking the courts for more and more money to build his defense and now wants the death penalty off the table. What's next? Asking if he can get out of jail?
Copyright 2010 WOIO. All rights reserved.
7831 N. Business Park Drive
Tucson, AZ 85743
(520) 744-1313
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Our "tea expert" is having fun during National Hot Tea Month by Playing with Matcha at the Office
January is National Hot Tea Month and although, BUNN® brewers are made for brewing coffee, we have many customers who place tea bags in the carafe or brew funnel to make tea. My Café® pod brewer features a Pulse button to extract more taste from tea pods and tea bags. Since it is National Tea Month we thought of no better way to pay homage to this beverage than to talk with our tea "expert". OK, well, she really isn't an expert, but around BUNN she is getting a reputation for knowing a lot about tea. (Watch out Dr. Brew, you may have some competition.) Read the fun post below on how our very own tea expert, Kris Houser, is celebrating National Hot Tea Month by playing with Matcha in the office.
Playing with Matcha at the Office
No, the headline is not a typo for "Playing with Matches at the Office." January is National Hot Tea month. Actually, I'm interested in celebrating this intriguing beverage every month. After taking the Specialty Tea Institute's Level 1 and 2 certification courses last year at World Tea Expo in Las Vegas, I'm now looking at tea with a laser focus. Working at BUNN, a lot of the time the conversation is centered on coffee. My co-workers now drop their heads and sigh every time I start to roll the tea flag up the pole and begin subtly waving as a reminder that specialty tea is as diverse and, arguably, nipping at the heels of coffee to become the hot beverage of choice in many markets. In fact, at the 2011 Tea Expo I learned that recent statistics show that, for the first time, the United States imported more tea than the UK and Germany.
This time last year, I would have been contemplating different varieties on my grocery store shelf to spotlight. This year, and thanks to my education through World Tea Expo and STI, I played with different preparation methods of Japanese Matcha. Said to be one of the healthiest of all teas, Matcha is the result of grinding the whole leaf into a nutrient-rich superfine powder. It is typically prepared in an elaborate ceremony by whisking the powder into 180 degree water. The premium Matcha is called "Ceremonial Grade".
Of course, my mini-lab gathered the attention of department colleagues who couldn't resist the vibrant green appearance (see photo to the left taken at my desk). Now I feel like the back-alley contact for many of my co-workers who hurry in while looking over their shoulder and say in a hushed tone, "Can you make me some more of that Green Chai?" Or, "Show me how the leaf unfurls again!" As you can see by the other photo of my cupping set, a China Green Tip unfurled magnificently.
I think it is ironic that our Dr. Brew sits at nearly the opposite corner of the building as my office. In some ways, it is like I'm starting my first chess move in the beginnings of a campaign to inch closer in sharing the lab and promoting how equally interesting specialty tea can be. Pawn to e4, Dr. Brew?


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Time has run out to arrest a serial bank robber in the Chicago suburbs who has earned the nickname "Wheaton Bandit" after the statue of limitations on the last crime expired .
The statute of limitations expired Wednesday at midnight despite a $50,000 reward.
The thief is accused of stealing about $150,000 from as many as 16 suburban Chicago banks since 2002, seven of them in Wheaton. He last struck Dec. 7, 2006 at the Glen Ellyn Bank and Trust.
The statute of limitations on bank robbery is five years. The expiration means the thief cannot be charged for any of the crimes.
Authorities said the "Wheaton Bandit" often wore a dark ski mask or hood. No one was injured in any of the robberies.
There is logic behind the statute of limitations.
In part, it's to protect people accused of crimes who are actually innocent.
If you're charged with a crime that happened ten or twenty years ago, your ability to mount a defense is compromised -- witnesses have moved or even died, memories have faded, and physical evidence has deteriorated.
The statute also keeps prosecutors moving ahead.
"Focus your energies. See what you have. And if you can move forward in two years, three years, four years, whatever the statute of limitations is, go forward. Turn your attention to something else," IIT Chicago – Kent College of Law's Harold Kent said. "Again I think society in the long run benefits from such limitations so from time to time there's a case that seems to fall in the cracks that seems to be totally unfair."
Another case that's been in the news also involves the statute of limitations.
Local prosecutors in upstate New York say they have strong evidence that former Syracuse University basketball coach Bernie Fine sexually abused two boys.
But they're not charging him because the statute of limitations expired.
In Pennsylvania, the law allows for an extension of the statute of limitations in cases of child molestation.
That's why Jerry Sandusky -- the coach from Penn State -- has been charged.
Illinois has a similar extension.
Didn't find what you were looking for?
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Details Emerge on Forza 4's Development, Kinect FeaturesForza Motorsport 4 is attempting a greater degree of racing fidelity than previous installments, according to a new details reported by MSN (via Eurogamer).
Turn 10 reportedly worked with the tire manufacturer Pirelli to study properties like weight transfer, and rented out every track that appears in the game so they could study it. Spending days at each track, the developers took "terabytes" of video and photos and traced each section of the road with a GPS system.
The developer is apparently planning to capture its own audio to capture the sounds of each vehicle. The report also states that Kinect users will be able to shift perspective by leaning, similar to head-tracking technology.
Forza 4 is due for release later this year. We haven't had a public hands-on, but it seems like Turn 10 is aiming to take the simulation racing crown from its long-term rival Gran Turismo 5.


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without your permission.
We will send you an email with an invite soon.
Hi kids, Happy Wednesday! @miriamgomberg @ImMarkBernhardt @CinziaRolling @dabarlow @SuzeInk @JennGHanford @sandyhubbard @A_P_Goodman
Kids are going hungry everyday, some will have their only meal at school. Then this happens. #nokidhungry
Hi Kids, how's the day? Having fun Mim? @miriamgomberg @Nickyhants @SuzeInk @A_P_Goodman @sandyhubbard
Hi kids! Happy Sunday. @miriamgomberg @ImMarkBernhardt @GailZahtz @CinziaRolling @sandyhubbard @Nickyhants @JennGHanford @dabarlow
25 Women in Marketing & NPOs You Should Know ~~ Do you know any of these women on @margieclayman's list?
Follow @Sherree_W on Twitter


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Simple but dazzling: a streamlined band with channel set gems is crowed with a round brilliant gem in a six-prong setting. See Details
Gemvara jewelry is truly personal: you design it, choosing gems and metals to celebrate your story, and we craft it just for you. We'd love to help you find your perfect piece! (more)What quality are your gemstones?
They are all-natural and hand selected fine quality. (more)


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Ascot Convertible Backpack
best complemented withPrevious Page
Super Léger International Carry-On
Medium Auto Close Umbrella
Sumatra Crossbody
- Voyageur
- Ascot Convertible Backpack
- Style #: 481759
- Free Shipping! See Details
The best-selling Voyageur collection offers streamlined and sophisticated feminine styling with smart details in lightweight designs. This versatile design that is ideal for travel, commuting or around-town use. It works as backpack or a tote with top carry handles and features a collapsible laptop compartment (holds 15" laptop). Made from lightweight nylon with leather trim, it offers numerous accessory pockets.
- Monogramming Available: No
- External Dimensions (wheeled items include handles and wheels) H x W x D: 14.25" x 12.5" x 4.5"
- Laptop Compartment Dimensions: 10.5" x 12.75" x 1"
- Fits Screen Size: Up to 15"
- Construction Material: Fabric
- External Features:
- Zip pocket
- Open pocket
- Side pocket
- Padded backpack straps
- Leather carry handles
- Detachable tag with mirror
- Internal Features:
- Collapsible laptop section
- Zip pocket
- Media pocket
- Open pocket
- Key ring
Everyday Free Returns
We want you to be fully satisfied with every product that you purchase from www.tumi.com. If you are not satisfied with a product that you have purchased, you may return the product within 30 days of delivery for a full refund of the purchase price, minus the shipping, handling, gift box, and other charges. Please note, however, that monogrammed and personalized items, including Accent Your Alpha, cannot be returned. Return shipping is free. You will be provided with a pre-paid UPS domestic label to return your purchase. If you cannot find the prepaid shipping label, please call our Customer Service Department at 1-800-299-TUMI (8864) or contact us by email.
We ask that the product be unused, in original boxes (whenever possible), and with all paperwork, parts and accessories in order to ensure credit. Sale merchandise will be issued a credit at the current selling price. Unused items purchased on www.tumi.com can also be returned to a US Tumi full price location. Please make sure to have all paperwork, parts and accessories to ensure credit. Store credit will be issued for items without documentation.
Welcome to the world of Tumi – the finest international brand of travel, business and lifestyle accessories. Since our founding in 1975, Tumi has been dedicated to providing our customers with an outstanding ownership experience.
Specifically, we make three commitments to our customers:
1. You will enjoy using our innovative products that are designed and manufactured to be the best;
2. You will experience world-class, after-sales customer service;
3. For a limited time after you purchase a Tumi product from an authorized Tumi store or dealer, you will be covered by our Limited Warranty.
Tumi's warranty extends to the original owner; it is straightforward and comprehensive, and just part of the total Tumi ownership experience.
Please click here to learn more about the Tumi Warranty.


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Outdoor Research
Longitude Hoody (Women's)
In Stock Product Number: 31378
A longer Longhouse - our soft and comfy sweater-knit fleece sweater - throwing on the stylish Longitude brings a touch of style to the backyard bonfire.
* This product does not qualify for shipping to all countries.
- Wicking
- Oversized hood with drawcord adjustments
- Internal front-zip stormflap
- Two handwarmer pockets with snap closures
- Flatlock seams Fabric- 100% polyester sweater-knit heathered fleece
Gender: Women's
Weight: Avg. Weight (oz./g): 13.5 / 382 M
Material: 100% polyester sweater-knit fleece
Season: F13
Vendor ProductId: 90955
Review ProductId: 31378


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posted by Colm Hanratty | 0 Comments
Our photo of the day is of dusk settling over Shark Pier in Port Elizabeth, South Africa.
>> Book hostels in Port Elizabeth
Have you been to Port Elizabeth? What did you think of it?
In our hostelworld.com travel blog we bring you all the latest company news and information on new additions to the site including podcasts, videos and more. You'll also get inside information on a variety of destinations across the globe as they're visited by our travel editor and writers.
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As the draft continues I will give my guess on each selection, plus the actual pick and my thoughts of each selection
1. Cleveland:
My Guess: Nerlens Noel
Actual Pick: Anthony Bennett - Wow, not one mock draft had Bennett going number 1, but the pick makes sense. Many scouts had Bennett has the most talented prospect in the draft. He'll fit in nicely with the Cavs.
2. Orlando
My Guess: Nerlens Noel
Actual Pick: Victor Oladipo - 0-2 so far. Best defender in basketball and will fit in nicely with the Magic. His leadership in the locker room is needed for a team that is clearly in rebuilding mode.
3. Washington
My Guess: Otto Porter
Actual Pick: Otto Porter - Finally got one right, but so did everyone else. Pretty much the only consensus of the draft. He's exactly what the Wiz need, a wing to play off of Wall and Beal. Good Pick Washington
4. Charlotte
My Guess: Nerlens Noel...one time!!
Actual Pick: Cody Zeller - This pick had been rumored over the last few days. I think he might be a little soft for the NBA but runs up and down the floor like a gazelle and should be solid player for the Bobcats, soon to be Hornets.
5. Phoenix:
My Guess: Noel...can't picture him slipping any further than this. If he does there must be huge concerns over his knee.
Actual Pick: Alex Len - This is why I don't work for ESPN. I really think Len will be a bust. He's big, raw, and is soft. I still think Noel would have been a better pick, but like I said before there must be tons of red flags over Noel's knee.
6. New Orleans
My Guess: Noel
Actual Pick: Noel - Finally he gets picked! Going to make a fearsome front court with him and Anthony Davis. ***Noel has been traded to Philadelphia***
7. Sacramento
My Guess: CJ McCollum
Actual Pick: Ben McLemore - Rumors all week were that the Kings were going to take McCollum but with McLemore on the board they had to take the former Jayhawk. He is going to be an All-Star for years.
8. Detroit
My Guess: Trey Burke
Actual Pick: Kentavious Caldwell-Pope - Thought Burke had to be the pick here but Caldwell can shoot. Looks like Knight will stay at the point.
9. Minnesota
My Guess: CJ McCollum
Actual Pick: Trey Burke - Don't see how he fits with Minnesota with Rubio at the point but I trust in Flip Saunders. Could be traded as well. ***Traded to Utah for the #14 and 21 picks****
10. Portland
My Guess: McCollum
Actual Pick: McCollum - Trailblazers go small school for the second straight year. Will play the two with Lillard at the point. Steph Curry clone.
11. Philadelphia
My Guess: Michael Carter-Williams
Actual Pick: MCW - Look at that two right in a row! Really good play maker but needs to work on his shooting. His height 6'6 makes him unique but will be a project for the Sixers.
12. Oklahoma City
My Guess: Steven Adams
Actual Pick: Adams - Three in a row, now that's a streak! OKC is going to run into cap issues in a few years and with the pick of Adams now they can make either Serge Ibaka or Kendrick Perkins tradable.
13. Dallas
My Guess: Dennis Schroeder
Actual Pick: Kelly Olynyk - According to Chad Ford this pick is going to Boston for the 16th pick and other pieces. Olynyk will take over at PF once KG is traded which could happen very soon
14. Utah (Going to Minnesota)
My Guess: Shabazz Muhammad
Actual Pick: Muhammad - If this pick goes to Minny as expected the Timberwolves in my opinion got a steal. Questions about his work ethic and a report coming out that he is a year older than thought dropped his stock. But he can score and will play well with Rubio and Love. Going to work his butt off to prove all the doubters wrong.
15. Milwaukee
My Guess: Schroeder
Actual Pick: Giannis Anteokounmpo - Who? A big unknown and this kid will probably not play in the NBA this year but seems to have a high upside.
16. Celtics (Going to Dallas)
My Guess: Schroeder
Actual Pick: Lucas Nogueira - From Brazil and will stay overseas for a year or two. Good pick by Dallas who are trying to free up as much cap space as possible to sign either Dwight Howard or Chris Paul
17. & 18. Atlanta
My Guesses: Mason Plumlee & Shane Larkin
Actual Picks: Schroeder & Larkin - Hawks take two point guards, signaling the Jeff Teague era in Atlanta is over. But it looks like Larkin is about to be traded to Dallas. Trade is still being put together.
19. Cleveland
My Guess: Jamaal Franklin
Actual Pick: Sergey Karasev - Russian guard who plans on playing in the US next year
20. Chicago
My Guess: Plumlee
Actual Pick: Tony Snell - Not a fan of this pick unless the Bulls are looking to trade Deng, which there have been plenty of rumors that they are
21. Utah (Pick going to Minnesota)
My Guess: Franklin
Actual Pick: Gorgui Dieng - Assuming this pick goes to Minny Dieng provides depth behind Love and Pekovic. All defense not much offense
22. Brooklyn
My Guess: Tony Mitchell
Actual Pick: Plumlee - He was my second guess behind Mitchell but was the best player left and will be solid presences backing up Brook Lopez.
23. Indiana
My Guess: Tim Hardaway Jr.
Actual Pick: Solomon Hill - If Danny Grainger doesn't resign after next season or if the Pacers look to trade him, Hill will be able to fill in nicely. NBA ready after spending four years at 'Zona
24. New York
My Guess: Franklin
Actual Pick: Hardaway Jr. - Very versatile player who I think should have gone much higher. Great athlete and scorer. Will replace JR Smith who will leave the Knicks via free agency.
25. Clippers
My guess: Franklin...hopefully fourth times a charm!
Actual Pick: Reggie Bullock - Not picking Franklin again...Bullock is a great shooter, something the Clippers need. Bold prediction Bullock starts at least 20 games this year.
26. Minnesota
My Guess: Alex Abrines
Actual Pick: Roberson - Looks like he will be dealt to Golden State. My guess was based on Minny taking the best European and stashing him overseas for a year or two and Abrines was the best still on the board. Roberson has a huge wingspan and for a guy only 6'7 averaged over 11 boards in the last two seasons.
27. Denver
My Guess: Franklin!
Actual Pick: Rudy Gobert - Gobert was projected to go higher and is a great pickup for the Nuggets. His 7'9 wingspan is one of the longest in NBA history.
28. San Antonio
My Guess: Franklin!
Actual Pick: Livio Jean-Charles - Done picking Franklin for real this time. Can't believe he's slipped this far. Spurs going international again. Jean-Charles will be stashed overseas for a few years.
29. Oklahoma City
My Guess: Isaiah Caanan
Actual Pick: Archie Goodwin - This pick is going to Phoenix. Goodwin has a lot of athletic ability but was out of position at Kentucky and a great value pick for Goodwin. He was one of the most highly recruited high school players just a year ago.
30. Phoenix
My Guess: Mitchell
Actual Pick: Nemanja Nedovic - This pick will go down in history as they last 1st round selection David Stern ever announced.
6 out of 30 correct...I'll stick to my day job.


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Molecular Profiling Informs Ovarian Cancer Therapy
NCI researchers are reporting that ovarian cancer cells with diminished ability to produce asparagine may be susceptible to the drug L-asparaginase (L-ASP), which has been used for more than 30 years to treat acute lymphoblastic leukemia. L-ASP metabolizes asparagine in the blood, selectively starving some types of cancer cells that cannot produce enough of the amino acid for their own needs.
Since recent studies have suggested a link between L-ASP activity and asparagine synthetase (ASNS) expression, the research team, led by Dr. John Weinstein, head of the Genomics & Bioinformatics Group (GBG) in NCI's Center for Cancer Research (CCR), analyzed expression of the ASNS gene in the NCI-60 panel of human cancer cell lines. The NCI-60 panel, used by NCI's Developmental Therapeutics Program to screen more than 100,000 compounds and natural products since 1990, is the most extensively profiled set of cancer cells in existence. Five different microarray platforms that GBG and their collaborators used for molecular profiling of the NCI-60 panel revealed a strong relationship between the anticancer activity of L-ASP and low expression of ASNS in ovarian cancer cell lines. Read more
NCCCP Increases Patient Access to Quality Cancer Care
NCI has created an infrastructure of clinical cancer research and cancer care that is unmatched anywhere in the world. The foundation of this successful system is the 61 NCI-designated Cancer Centers, which have been the bedrock of the continual improvements made in prevention, screening, treatment, and palliative care. However, the fact still remains that 85 percent of cancer patients receive their care at the local community level. Given this, if we are to bring the latest scientific advances to the patient, we must continue to develop programs to reach them in the communities where they live.
Cancer is a disease of the aging. This rapidly growing patient population, as well as underserved or disadvantaged populations, need more support in order to access quality care. I agree with Dr. John Seffrin, CEO of the American Cancer Society, who has said that access by patients with cancer to state-of-the-art care - to the latest advances in genomics and proteomics - will be a bigger determinant to mortality than any risk factors identified today. It is for this reason that I believe NCI needs to create a new rim of clinical cancer research and care beyond the NCI-designated Cancer Centers Program to build on the superb efforts of these Centers. By virtue of their ability to directly address issues of delivery, many Centers have invested in creating networks of affiliated community cancer programs. Read more
Molecular Profiling Informs Ovarian Cancer Therapy
NCI researchers are reporting that ovarian cancer cells with diminished ability to produce asparagine may be susceptible to the drug L-asparaginase (L-ASP), which has been used for more than 30 years to treat acute lymphoblastic leukemia. L-ASP metabolizes asparagine in the blood, selectively starving some types of cancer cells that cannot produce enough of the amino acid for their own needs.
Since recent studies have suggested a link between L-ASP activity and asparagine synthetase (ASNS) expression, the research team, led by Dr. John Weinstein, head of the Genomics & Bioinformatics Group (GBG) in NCI's Center for Cancer Research (CCR), analyzed expression of the ASNS gene in the NCI-60 panel of human cancer cell lines. The NCI-60 panel, used by NCI's Developmental Therapeutics Program to screen more than 100,000 compounds and natural products since 1990, is the most extensively profiled set of cancer cells in existence. Five different microarray platforms that GBG and their collaborators used for molecular profiling of the NCI-60 panel revealed a strong relationship between the anticancer activity of L-ASP and low expression of ASNS in ovarian cancer cell lines.
When the researchers and their collaborators then used RNA interference to reduce the expression of ASNS fivefold in three of those cell lines, L-ASP became much more active. With the cell type that expressed the least ASNS, the activity of L-ASP increased more than 500-fold, and that enhanced killing was maintained in a classically multidrug resistance cell line.
"We hope the level of ASNS gene activation will one day be a useful tool for identifying ovarian cancer patients who will benefit from L-ASP treatment," said lead author Dr. Philip Lorenzi, a Pharmacology Research Associate Program fellow in GBG. "However, it should be remembered that results in cell lines don't necessarily reflect what will happen in clinical tumors."
The group's collaborators have opened a phase I clinical trial to test the safety of L-ASP in patients with solid tumors and non-Hodgkin's lymphoma and to begin assessment of ASNS as a biomarker.
The ASNS study, published online November 7 in Molecular Cancer Therapeutics, launches a new "Spotlight on Molecular Profiling" series of articles, which will highlight high-quality molecular profiling research and provide genomic and proteomic data for many types of cancer.
According to their interests and expertise, researchers around the world will be able to mine the molecular profiles published in the series with the ultimate goal of developing personal molecular profiles and improving cancer detection, treatment, and prevention. To facilitate those uses of the data, GBG has developed an interactive database and set of query tools called "CellMiner."
"If cancer research in the pregenomic era was a cottage industry dedicated to the study of individual molecules and processes, then the postgenomic era is an industrial revolution defined by technological advances that allow for large-scale screening of thousands of genes at once," Dr. Weinstein concluded. "This new spotlight on molecular profiling is important because it will emphasize that not all genetic changes are the same and not all cancers are the same, and they should not be treated as such."
By Heather Maisey
NCCCP Increases Patient Access to Quality Cancer Care
NCI has created an infrastructure of clinical cancer research and cancer care that is unmatched anywhere in the world. The foundation of this successful system is the 61 NCI-designated Cancer Centers, which have been the bedrock of the continual improvements made in prevention, screening, treatment, and palliative care. However, the fact still remains that 85 percent of cancer patients receive their care at the local community level. Given this, if we are to bring the latest scientific advances to the patient, we must continue to develop programs to reach them in the communities where they live.
Cancer is a disease of the aging. This rapidly growing patient population, as well as underserved or disadvantaged populations, need more support in order to access quality care. I agree with Dr. John Seffrin, CEO of the American Cancer Society, who has said that access by patients with cancer to state-of-the-art care - to the latest advances in genomics and proteomics - will be a bigger determinant to mortality than any risk factors identified today. It is for this reason that I believe NCI needs to create a new rim of clinical cancer research and care beyond the NCI-designated Cancer Centers Program to build on the superb efforts of these Centers. By virtue of their ability to directly address issues of delivery, many Centers have invested in creating networks of affiliated community cancer programs.
One of the missions of NCI, however, is to conduct research on how to meet the health care access crisis sitting on our doorstep, and to determine the best ways to bring prevention, early diagnosis, treatment, and new science to all of those affected with cancer. Therefore, NCI has launched a new initiative, the NCI Community Cancer Centers Program (NCCCP), which is being tested as a pilot project - not in competition with programs that do community outreach, but as a complementary program to the existing network of NCI-designated Cancer Centers, Community Clinical Oncology Program (CCOP) sites, and other academic medical center cancer programs.
NCCCP seeks to broaden and magnify the impact of our research advances and create a more comprehensive National Cancer Program that builds on our strengths. NCI's mission is to fund and perform research, not to deliver care. As a pilot, the program, which will cost $9 million over its 3-year span, is intended to help answer some of the most pressing clinical cancer-related issues, including one of the most serious problems - disparities in care.
When the NCI-designated Cancer Centers Program was being created during the 1970s, there was a need for special care units in large hospital settings to manage the side effects associated with highly toxic chemotherapeutic treatment regimens. Today, it is possible to propose this next sphere of clinical research and outreach because the new generation of drugs are targeted and less toxic, and will be able to be administered in early-phase clinical studies in a community practice setting.
To qualify for the NCCCP pilot, Centers will need to have established systems able to support clinical trials and a substantial patient base to be able to accrue patients to clinical trials, as well as effective means of serving the underinsured and uninsured. The Centers will also need to be able to apply resources effectively to build information technology capability, including electronic patient medical records, as well as support biospecimen collection. Sites must be unconditionally accredited by the American College of Surgeons Commission on Cancer, the Joint Commission on Accreditation of Healthcare Organizations (JCAHO), and the College of American Pathologists or JCAHO for laboratory services. There also is a preference for sites to be participating in national or state programs for screening and treatment to incorporate other efforts to improve cancer care.
A major goal of NCCCP will be to create a cohort of oncology patients linked through electronic records and common bioinformatic databases. If we hope to accelerate the timeline to drug approval, we need to establish linked multisite clinical trial networks. NCCCP offers the infrastructure that reaches deeper into the community to bring together these patient cohorts.
The interplay of the NCCCP pilot will be an important step in transferring the rigors of clinical cancer care to local hospitals and clinics. I believe that by introducing clinical research standards to the local setting, it will raise the quality of care and acquaint community physicians with state-of-the-art cancer care management.
Through this pilot, we hope to identify effective ways to increase accrual to clinical trials, assess programs to bridge the disparities gap, develop standardized tissue banks that will enable future research in carcinogenesis, and bring community-based oncology into the era of electronic medical record keeping and information technology networks.
Like any well-designed project of this nature, evaluation metrics will be established for NCCCP, and independent assessments will help us determine whether it is something that, approximately 3 years from now, we need to revisit, revise, or even expand.
With NCCCP, we are trying to answer some ambitious questions for which there are no easy answers. But I am a firm believer that if we make the effort to identify the parameters and imperatives behind delivering high-quality care to people in communities across the country, we will reap the benefits - as measured by many cancers prevented and lives saved.
Dr. John E. Niederhuber
PSA Velocity Distinguishes More Lethal Prostate Cancer
Screening for prostate specific antigen (PSA) can detect early stage prostate cancer, but evidence is mixed about whether this knowledge improves health outcomes, according to the U.S. Preventive Services Task Force. However, new findings in the November 1 Journal of the National Cancer Institute (JNCI) indicate that the change in PSA over time (PSA velocity) is a better marker for more aggressive prostate cancers (see related article); thus, the authors concluded that PSA screening should begin earlier to capture a more dynamic view of prostate carcinogenesis.
Dr. H. Ballantine Carter and colleagues of Johns Hopkins University and the National Institute on Aging (NIA) showed that men whose PSA rises less than 0.35 ng/mL per year have only an 8 percent chance of prostate cancer death 25 years after their velocity was determined. This risk is nearly five times lower than men whose PSA velocity rises more quickly than 0.35 ng/mL per year, 46 percent of whom will succumb to their disease in that same time frame.
The researchers were able to look back at data from a large, ongoing prospective cohort study begun by NIA in 1958 and test blood samples for PSA in 980 men - 124 of whom were eventually diagnosed with prostate cancer. In a related editorial, Dr. Timothy R. Church of the University of Minnesota said the study encourages optimism about the value of PSA velocity, though it had "weaknesses…and the implication of the results is not straightforward."
And while the study did not examine whether men with high PSA velocity might have benefited from early treatment, the authors concluded that "as much as 10 to 15 years before diagnosis, it would appear that PSA velocity is an indicator of disease that is destined to progress and threaten life."
Tobacco Use Decline Has Stalled, CDC Report Shows
The overall prevalence of smoking among U.S. adults was the same as in the previous year, in contrast to a steady decline seen over the last 8 years. This news, based on data from the Centers for Disease Control and Prevention's (CDC) annual National Health Interview Survey (NHIS), was reported in the October 27 Morbidity and Mortality Weekly Report.
The NHIS questionnaire was administered to a nationally representative sample of 31,428 people aged 18 years or older. The survey found that, in 2005, an estimated 20.9 percent of U.S. adults - 45 million people - were current cigarette smokers (people who had smoked at least 100 cigarettes during their lifetimes, and were now smoking every day or on some days); 80.8 percent smoked every day, and 19.2 percent smoked some days. As in past years, there were striking differences between population groups. For example, smoking prevalence among highly educated Americans (those with graduate degrees) fell to 7.1 percent, while prevalence among those with a GED was 43.2 percent. Prevalence was also higher among people living below the poverty level than among those at or above the poverty level (29.9 percent vs. 20.6 percent).
The authors cite smaller annual increases in the price of cigarettes, increased tobacco industry expenditures on price discounts, and a significant drop in state tobacco control program funding as possible contributors to their findings. "The huge differences in smoking rates associated with income, education, and other factors are of great concern to tobacco control researchers and practitioners," said Dr. Cathy Backinger, acting chief of NCI's Tobacco Control Research Branch in the Division of Cancer Control and Population Sciences (DCCPS).
More information about tobacco use and cancer can be found at http://www.cancer.gov/cancertopics/smoking.
New Therapeutic Target Identified in Retinal Tumors
A new study published in the November 2 Nature has shown that overexpression of a protein in the p53 cell-signaling pathway called MDMX allows retinoblastoma cells to survive and proliferate. While previous studies have implicated mutations in the tumor-suppressor gene RB1 as necessary for the formation of retinoblastoma, researchers had thought that these tumors developed independently of mutations in the p53 pathway.
The investigators from St. Jude Children's Research Hospital in Memphis first determined that MDMX was overexpressed in retinoblastoma tissue samples and that the p53 pathway downstream of MDMX was fully functional in several retinoblastoma cell lines. They next induced MDMX expression in a mouse model of retinoblastoma. Expression of the protein promoted both proliferation and survival in cells that were genetically susceptible to malignant transformation.
When the investigators introduced MDMX into cultured human retinas, cell death was suppressed even if RB1 was inhibited at the same time. When a mutant form of MDMX that cannot bind to p53 was introduced in place of normal MDMX, cells underwent apoptosis (cell death).
The investigators next tested a small-molecule inhibitor called nutlin-3 on retinoblastoma in vitro and in vivo. Nutlin-3 was able to inhibit MDMX from binding to p53 in vivo, and a subconjunctival injection of nutlin-3 plus the chemotherapy drug topotican synergistically killed retinoblastoma cells in a mouse model, with no systemic or eye complications.
The authors encourage further clinical examination of this drug combination: "On the basis of our preclinical studies, we propose that subconjunctival administration of these two drugs could achieve the same synergistic effect in individuals with retinoblastoma without causing the side effects associated with prolonged systemic exposure to broad-spectrum chemotherapeutic drugs."
Epirubicin Improves Standard Breast Cancer Chemotherapy
The addition of several treatment cycles with the anthracycline drug epirubicin (Ellence) to the standard adjuvant chemotherapy regimen for early breast cancer significantly increased relapse-free and overall survival rates compared with patients using the standard therapy alone, according to an analysis of two studies in the November 2 New England Journal of Medicine.
The National Epirubicin Adjuvant Trial (NEAT) and the BR9601 trial included 2,391 women who received either the combination of four cycles of epirubicin and the standard CMF regimen (cyclophosphamide, methotrexate, and fluorouracil) or CMF alone. At a median follow-up of 48 months, the relapse-free and overall survival rates were significantly higher in the epirubicin-CMF groups than in the CMF-alone groups - the 2-year relapse-free survival was 91 percent vs. 85 percent, and the 2-year overall survival was 95 percent vs. 92 percent.
"The overall incidence of adverse effects was significantly higher with epirubicin plus CMF than with CMF alone but did not significantly affect the delivered-dose intensity or the quality of life," reported the researchers, led by Dr. Christopher J. Poole of the Cancer Research U.K. Clinical Trials Unit in the United Kingdom.
In an accompanying editorial, Dr. Mark N. Levine and Timothy Whelan noted as background that the 2000 NIH Consensus Conference recommended anthracycline-containing regimens for the adjuvant treatment of breast cancer. Although the analysis of the two studies showed modest benefit from adding epirubicin to the standard CMF regimen, the editorial cautioned that the considerable toxic effects and costs require that physicians "tailor the aggressiveness of the chemotherapy to the risk of recurrence" in each patient.
Helping Radiologists Improve Breast Cancer Screening
The radiologists who read mammograms in the United States face the daunting task of finding 3 to 6 cancers in every 1,000 mammograms. But despite the challenge, a recent study reported that most radiologists exceed performance levels set in the early 1990s.
The study, which appeared in the October Radiology, used data from the NCI-sponsored Breast Cancer Surveillance Consortium (BCSC) to evaluate how well 807 radiologists around the country were performing different aspects of breast cancer screening.
"We now have a baseline of where physicians are practicing," says lead author Dr. Robert Rosenberg of the Radiology Department at the University of New Mexico in Albuquerque. "If you look at cancer outcomes, the radiologists are doing a good job."
The performance levels set back in the early 1990s were basically educated guesses about how well a radiologist could do. Today, thanks to the BCSC, a wealth of data exists, and researchers are using the information to improve breast cancer screening.
The findings by Dr. Rosenberg's team provide performance "benchmarks" that may help radiologists identify which areas of their practices could be improved, says Dr. Stephen Taplin of NCI's DCCPS.
"Until you know where you stand, you can't figure out what you need to do to improve your performance," adds Dr. Taplin, who oversees the BCSC program.
Dr. Rosenberg's team analyzed 2.5 million mammography screening exams done between 1996 and 2002 involving 1.1 million women. They compared screening exam results with each woman's clinical outcome in the 12 months following her initial exam.
After follow-up work, cancer was diagnosed in 4.8 per 1,000 women. When a radiologist advised that a biopsy be performed immediately, 34 percent of the results indicated cancer.
The 807 radiologists came from nearly 200 different facilities that provide information on screening mammography to the BCSC.
The consortium, launched in 1994, includes five research sites currently gathering information on mammography through partnerships with facilities in their geographic areas. The facilities range in type from traditional radiology practices and hospital-based services to mobile mammography vans and pathology laboratories.
More than 225 published studies have used data collected by the BCSC.
"You could not do this particular study without the BCSC," notes Dr. Taplin. "It's very complicated to standardize data collection and definitions."
The findings suggest the need for more research on the recall rate - the proportion of women called back by radiologists for more evaluation based on a finding in a mammogram.
The recall rate should be less than 10 percent, and it has been higher in the United States than in Europe. The study reports a wide range, with some radiologists recalling 4 to 5 percent of women while others recall 20 percent or more.
"The question is whether we can narrow the range down," says Dr. Rosenberg, noting that the challenge will be to do so while detecting cancer at the same level.
A second study in the October Radiology used BCSC data to explore another aspect of screening mammography: whether radiologists are making the appropriate recommendations for follow-up care after assessing a mammogram.
This question is related to performance benchmarks because if the assessments are not properly linked to recommendations, then the benchmarks will be inaccurate and so will the audits that radiologists do to compare themselves to the benchmarks.
To answer the question, Dr. Berta Geller of the University of Vermont and colleagues analyzed several years of data before and after the final rules of the Mammography Quality Standards Act (MQSA) went into effect in April 1999.
These rules dictate the terminology that radiologists should use when making recommendations based on a finding in a mammogram. Previous studies found that assessments do not always match recommendations; the new study reports progress.
For example, in 1996 only 51 percent of the screening mammograms appropriately recommended a short-interval follow-up (usually 6 months) for women with lesions classified as "probably benign." By 2001, the number was up to 76 percent.
"The surprise is how quickly people adopted the new terminology," says Dr. Taplin.
Dr. Geller attributes the improvement to several factors, including greater familiarity with the terminology among radiologists due to the American College of Radiology's Breast Imaging Reporting And Data Systems (BI-RADS) and to the MQSA regulations.
More radiologists also are using computer software that automatically suggests recommendations when findings are entered on the computer. "This is a teaching tool, and radiologists who have difficulty with the terminology may find it useful," says Dr. Geller.
"Because breast cancer affects so many women and because mammography is the best current screening method, we're always trying to find ways to improve mammography," she says.
By Edward R. Winstead
Following are newly released NCI research funding opportunities:
Development, Application, and Evaluation of Prediction Models for Cancer Risk and Prognosis
This funding opportunity will use the R21 award mechanism. See http://cri.nci.nih.gov/4abst.cfm?initiativeparfa_id=3552. Inquiries: Dr. Andrew N. Freedman - firstname.lastname@example.com; Dr. Isis S. Mikhail - email@example.com; Dr. J. Milburn Jessup - email@example.com
Facilitating Interdisciplinary Research via Methodological and Technological Innovation in the Behavioral and Social Sciences
This funding opportunity will use the R21 award mechanism. See http://cri.nci.nih.gov/4abst.cfm?initiativeparfa_id=3549. Inquiries: Dr. Patricia L. Mabry - email@example.com; Dr. Lisa Onken - firstname.lastname@example.com
Understanding and Promoting Health Literacy
This funding opportunity will use the R21 award mechanism. See http://cri.nci.nih.gov/4abst.cfm?initiativeparfa_id=3550. Inquiries: Dr. Sabra F. Woolley - firstname.lastname@example.com
Treating Adult T-Cell Leukemia/Lymphoma
Name of the Trial
Principal Investigators
Why This Trial Is Important
In ATLL, HTLV-1 causes abnormal and uncontrolled growth of T cells (immune system cells that normally fight infections and disease). These malignant T cells often express high amounts of a protein called Tac, which is a receptor protein for the immune system hormone interleukin-2.
Denileukin diftitox (Ontak) is a genetically engineered protein that combines segments of interleukin-2 and diphtheria toxin. Diphtheria toxin is a poison made by the same bacterium that causes the disease diphtheria, which can be fatal.
Denileukin diftitox binds to the Tac protein on ATLL cells and is subsequently absorbed by them, causing the cells to die. Researchers hope that administering denileukin diftitox to patients with ATLL will help these patients survive longer.
"Denileukin diftitox is approved by the Food and Drug Administration to treat cutaneous T-cell lymphoma, and it is fairly well tolerated by patients," said Dr. O'Mahony. "We hope that this drug will prove to be a more effective treatment than traditional chemotherapy for patients with ATLL, a rare disease that is usually associated with a poor outcome."
Who Can Join This Trial
Study Site and Contact Information
An archive of "Featured Clinical Trial" columns is available at http://cancer.gov/clinicaltrials/ft-all-featured-trials.
Conference Moves Transdisciplinary Science Forward
OSPA Releases 21 Disease-Specific Snapshots
Nanotech Investigators Meeting Embraces Team Science
Challenges in translation of technologies to the clinic, as well as featured experts from industry and the FDA who defined key steps toward commercialization, were highlighted. Various Alliance work groups presented progress on bioinformatics tools development, data and research tools sharing, and multifunctional nanoscale drug delivery systems. Several poster sessions fostered connectivity among Alliance investigators and encouraged the development of new ideas for research collaborations. Students and postdoctoral candidates currently working within their Alliance programs also attended.
New Ovarian Cancer Booklet Available
Science Offers Online Alerts and Research Summaries
NCI-FDA Training Program Focuses on Translation
These days, however, he's spending most of his time in training sessions and meetings at the Food and Drug Administration (FDA) learning how to review applications from drug companies seeking approval to market a new drug or conduct a clinical trial of an investigational agent.
"It's a hard thing to train for," he says. "But it's just like anything else. You have to jump in and do it."
Dr. Lechleider is one of the first fellows in a novel training program developed by NCI and FDA's Interagency Oncology Task Force (IOTF). Its goal: To develop a cadre of basic and clinical researchers who also understand the legal and regulatory aspects of delivering new drugs or diagnostics to the clinic.
"It's definitely a unique program," says Dr. Jonathan Wiest, associate director for training and education in NCI's CCR. "It's especially rare to have two agencies within HHS working together on a program like this." Dr. Wiest, along with Drs. Mary Poos and David Brown of the FDA, oversee the training program.
The IOTF Joint Fellowship Program is composed of four different programs, each with curricula that are tailored somewhat differently depending on a fellow's education, training, and interest. For Dr. Lechleider, the program offered him an opportunity to move in a new direction.
"I was a basic scientist, with no clinical involvement," he says. "I wanted to be more directly involved in drug development."
The first year of Dr. Lechleider's 3-year program was dedicated to clinical training at the Bethesda Naval Medical Hospital and at the NIH Clinical Center with patients enrolled in NCI clinical trials.
Now more than a month into the regulatory training, he admits it's quite a change.
"It's a different way of thinking," he says. "The clinical training has been great because when I start to look at trial designs, having seen patients treated on clinical trials makes it easier to interpret applications and evaluate them for risk and benefit."
Another fellow in the program, Dr. M. Stacey Ricci, agrees that the program has given her a different mindset.
"Coming from a background in basic research, it has been a great way to learn what it takes to get a promising cancer drug into clinical trials," says Dr. Ricci, who came to the program after completing her postdoctoral training at the University of Pennsylvania. "Training at the FDA has provided an opportunity to understand, in great detail, what the critical safety and manufacturing issues are for successful drug development." Much of Dr. Ricci's training at the FDA has focused on biologics, particularly monoclonal antibodies.
In addition to their regulatory training, both Drs. Ricci and Lechleider will continue conducting research in FDA and NCI laboratories, respectively.
Established as a 3- to 5-year pilot, the program definitely addresses a pressing need.
"When you look at the cost of getting a drug through to the market, one of the most expensive and time-consuming aspects is meeting the requirements for gaining regulatory approval," says Dr. Wiest. "This program is about training world-class scientists who understand how to make that happen."


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Emanual Ringelblum
Inside the Ringelblum Archive
A guided tour of Polish Jewry's greatest treasure, once buried in the rubble of Warsaw
Another 'Boardwalk' Casualty: Waxey Gordon11:32 AM —
This season's time jump bypasses much of the bootlegger's criminal career
Ring in the New Year With a Manischewitz Fizz10:27 AM —
Celebrate Rosh Hashanah with a clever—and kosher—holiday cocktail
Israel Kills Two Suspects in June Kidnappings9:56 AM —
Hamas identified the men as members of the militant group's armed wing
Jury: Arab Bank Supported Hamas Operations6:41 PM —
Jordanian bank found liable for knowingly transferring terrorism funds
Despite Unrest, Hasidim Head to Ukraine5:07 PM —
Security concerns won't derail annual Breslover pilgrimage to Uman
Jack's Wife Freda's Rosh Hashanah Specialty1:51 PM —
The NYC restaurant will be serving honey and red wine-braised short ribs
Meet the Syrian Sugihara12:52 PM —
Rogue diplomat secured passports for rebels fleeing Assad's bloody regime
The Road to the New Jerusalem, Part 311:20 AM —
The story behind a story about a young woman's search for a new kind of Jewish community
High Holiday Reading from Tablet10:35 AM —
A preview of what's to come over the next few weeks
Facebook, Unchain Me!By Adam Janofsky — 'Chained wives,' refused Jewish divorces by their husbands, take to social media
How Peace Negotiator Martin Indyk Cashed a Big, Fat $14.8 Million Check From QatarBy Lee Smith — One Middle Eastern nation does indeed pay to influence U.S. foreign policy. Hint: It's not Israel.
Love Syndrome: Israel Story, Episode 2By Israel Story — Chaya Ben Baruch's sixth child was born with Down syndrome. Then she did what every good mother does—set out to find him a mate.
15 American Rabbis You Haven't Heard Of, But Should
How To Make Gefilte Fish That Your Guests Will Actually Want To Eat
Breaking the Jewish Community's Silence Around Suicide
An Insider's Guide to the Most Important Story on Earth
Former AP Reporter Confirms Matti Friedman Account
A Rosh Hashanah Meal With Meaning
Twitter: tabletmag
- RT @shdeen: Agree w/ it or not, @sovietsonja's piece about shul politics/hipster Hasids/Jewishness is a stunningly terrific read. http://t.…
Love Syndrome: Israel Story, Episode 2
Chaya Ben Baruch's sixth child was born with Down syndrome. Then she did what every good mother does—set out to find him a mate.
Leonard Bernstein: A New Look at His Rise, His Foibles, and His Impact on Music History
The dynamic conductor and genius behind 'West Side Story' also wrote classical works. Allen Shawn explores what they reveal.
How a Reporter Dispelled Myths About Ultra-Orthodox Jews Gaming the System
Batya Ungar-Sargon discusses her exposé on the tax rolls and funding cuts that fueled an ethnic rift in East Ramapo, N.Y.
- Easy Rosh Hashanah Recipe for Kids: Honey Joys!
- Watch Shimon Peres Look For a Job Post-Presidency
- Not Your Bubbe's Rosh Hashanah Dessert: Salted-Caramel Apple Galette
- Jewish College Student Survey: Israel is Most "Crucial Issue" For Young Jews Today
- Real Housewives of New Jersey: the Losers are Back
- A Conversation with Amber Marchese of Real Housewives of New Jersey
- Jonathan Tropper?s ?This is Where I Leave You? finds humor during shivah
- Local artist tackles Jews and sex in ?Transparent? with Jeffrey Tambor


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Baby Onesies & Shirts
Baby onesies, lap tees and rompers. From celebrities to silly little squirrels, we've got a onesie or shirt for every one-of-a-kind baby. Choose from several colors of 100% cotton American Apparel onesies and lap tees to create your perfect shirt! Check out our hilarious "That's What She Said" and other funny baby shirts by checking out our Funny Theme!
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Regular Price: $22.00
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Rock Star One Piece by Stella Blu
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Kohl's department stores in Clearwater, Florida are stocked with everything you need for yourself and your home - apparel, shoes & accessories for women, children and men, plus home products like small electrics, bedding, luggage and more. At Kohl's department stores Clearwater, we not only offer the best merchandise at the best prices, but we're always working to make your shopping experience enjoyable.
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Engineering An Empire DVD
Sale Price: $39.98
To Order by Phone Call 1-800-933-6249
- Additional Details
- Format: DVD
- Rating: Not Rated
- Number of Discs: 4
- Run Time: 564 Minutes
- Region: Region 1
- Aspect Ratio: Fullscreen
- Language: English
- Studio: A&E Home Video
- DVD Release Date: February 27, 2007
- Audio: ENGLISH: Dolby Digital Stereo
- Cast: Peter Weller
- Genre: Documentary
- Color: Color
- Includes:
Behind The Scenes Featurette
- Release Date: 2006
- GREECE: The cradle of Western civilization sustained remarkable technological advancement for over 1,000 years, including such masterpieces as the Tunnel of Samos and the Parthenon.
- GREECE: AGE OF ALEXANDER: After a century of tremendous accomplishment, Greece's territorial ambitions were stymied by constant warfare - until Alexander ventured abroad and initiated the Hellenistic era.
- THE AZTECS: The Aztecs became one of the greatest civilizations in history through brilliant military campaigns and technological mastery of their harsh environment.
- CARTHAGE: Find out how Carthaginian engineers harnessed their extensive resources and manpower to develop some of the ancient world's most groundbreaking technology.
- CHINA: Century after century, China's regal emperors mobilized immense peasant armies to accomplish unfathomable feats - including the most ambitious construction project ever accomplished.
- RUSSIA: From the Moscow Kremlin to St. Petersburg to the Trans-Siberian railroad, examine the architecture and infrastructure that led to the rise and fall of the Russian Empire.
- GREAT BRITAIN: Through the centuries, the British Empire used extraordinary engineering technology to become an industrial and military titan, giving rise to such inventions as the first locomotive.
- THE PERSIANS: The engineering feats of the mysterious Persian Empire include a water management system, a paved cross-continent roadway, and one of the Seven Wonders of the Ancient World.
- THE MAYA: By 900 AD, the once-glorious Mayan cities disappeared. Unravel the mystery surrounding this mythic civilization through its spectacular infrastructure and architecture.
- ENGINEERING AN EMPIRE culminates with volume 4 as it follows the rise of one of the greatest military strategists in history, one who spurred on some of the worlds most iconic masterpieces, and uncovers the brilliant gem of the Dark Ages: the Byzantine Empire. Finally, watch Italy magnificently reawaken and build on a scale not witnessed since the ascent of Rome.
- NAPOLEON: STEEL MONSTER: When France stood on the precipice of disaster, one of the most legendary military strategists in history arose from its ashes: Napoleon.
- THE BYZANTINES: As much of the world descended into the Dark Ages, the Byzantine Empire emerged with ruthless might and supreme ingenuity, ruling over vast swaths of Europe and Asia.
- DA VINCIS WORLD: After the deep sleep of the Dark Ages, it wasnt until the 11th-century that autonomous city-states emerged in Italy, revitalizing metropolises and paving the way for the Renaissance.
Governments may be established, countries may be born, but empires are built.
Leaving the dusty history books behind, ENGINEERING AN EMPIRE takes to the streets -as well as the sewers, mountaintops, jungles and beyond- to trace the magnificent physical achievements and technologies of past societies. Host Peter Weller travels around the world and, assisted by cutting-edge computer renderings and note-perfect dramatizations, far back in time to chronicle the innovation and architectural brilliance that gave birth to modern civilization.
Experience street-level life in ancient Greece and China; track the expansion of history's most ambitious cultures like Rome and Byzantium; and marvel at the touchstone achievements -the Parthenon, Tenochtitlan, the Great Wall, Chichen Itza, and many more- that defined the past and awe us to this day. Computer enhancements and location filming transport you to the very sites where empires thrived and collapsed.
ENGINEERING AN EMPIRE breathes life into the past, reanimates the achievements of the history's greatest civilizations, and illuminates the ingenuity and boldness of our forebears. This magnificent DVD collection of the entire series will leave you stunned and amazed.
DVD Features: Season 1 Behind-the-Scenes Featurette


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Rated 4.6 out of 5Â by 66 reviewers.
adidas Basketball Accessories
Adizero Speedwrap Ankle Brace Right Foot
Medium Lead (P82145)
Size Chart
+ Save To Wishlist
Rated 2 out of 5Â by Nelsonation Eh... Not good at all, I wear a size 11 the brace does not prevent a ankle roll. If your ankle rolls out the material just streches. The medal plate is ver uncomfortable on the ball of your ankle. For $30 you can get a very nice ankle brace that will prevent ankle rolls. If you to the a store and try them on stand on the back of your heal and roll your ankle you will feel exactly were the brace does not support your ankle. If your a shooter with no vertical there nice for style. If you plan on jumping, crossing and rebounding these are not the product for you. Find a footlocker that has them so you can try them on before you order them online. Trust me. April 2, 2012
Rated 5 out of 5Â by StepZ Super light and protective ankle brace Friend bought these for me for my birthday and loved them ! Best ankle brace I have ! About 5-6 weeks ago, I tore a ligament in my right ankle part then bruised it. It still hurts now but after wearing this brace for about 3-4 hours for basketball practice, some of the pain is gone. Whether it's in the head, to be honest, I don't really care ! It temporarily eased my pain which helped me A TON. They fit nicely in my adidas Crazy Light and I don't need to lace it all the way up to feel secure in the collar part. I also liked how the hard plate is only on the outside of the ankle to prevent rolling which was a great plus for me. The elephant print-like also seems to have more grip for a more secure, lockdown feel in the shoe. Thanks adidas for creating this product ! July 20, 2011
Rated 5 out of 5Â by jbhaloed Best in-Game Ankle Brace on the market I really didn't think that this brace would be supportive enough for my ankles before I bought them but they are light, easy to put on and have great support. Honestly you can hardly feel that you have them on. Another thing is that you should definitely abide by the sizing conventions regardless of what size ankle brace you wear normally. For example I wear a sz 13 shoe so I bought the XL but i had originally bought the Medium because thats the size i wear on ASO braces b/c of how narrow and slim my foot is. February 19, 2011
Rated 5 out of 5 by Terrance Best Accessory For A Scoring Style Point Guard I gotta admit it's great, I fit this with my adidas TS Supernatural Creator and adidas adiZero⢠Rose 2.5. It's fits me well and giving me a good performance on the court. For better performance make sure you equip with both side of the adiZero⢠Speedwrap. adiZero⢠Speedwrap increases my quickness, penetration, speed and stability of my crossovers with fancy lay-ups finishing at the rim. It's really great for Scoring Point Guard like me. I am 178 cm at 17. I can't dunk but I can do fancy lay-ups. I have good vertical leap. Thank you for reading my review. August 31, 2012
Rated 5 out of 5Â by AdiZeroAP Every basketball player should have this When I first got myself a pair of the Adidas Speedwrap ankle braces I thought to myself, these are so light and they feel so snuggly. I love the strap because the 3 stripes are very noticable even when wearing a high top basketball shoe. There were many times I should have easily rolled or sprain my ankle but I didn't because I was wearing these ankle braces, the support they provide is top level protection! I am not over exaggerating. The Speedwraps fit perfect in my Adidas basketball shoes and I couldn't see it anyother way. January 20, 2012
Rated 5 out of 5Â by stat Ultralight Protection Adidas would do well to offer these wraps in black and white to blend in with a greater variety of shoes. Having said that, they don't look bad at all. Having suffered many ankle injuries in the past, I've probably tested about 90% of the braces on the market. While others have offered superior protection and durability, they were always pretty constrictive and bulky. This product feels like a second sock. Remarkably light and comfortable! Regarding the sizing, I'm a 10.5-11 and the large fits like a glove. The fit is essential here, as the strategic protection will surely lose its efficiency should you purchase the wrong size. These are easy to slip on and off, very comfortable, relatively well constructed and nearly weightless. I cannot emphasize that last point enough. You completely forget that you're wearing a protective device once you get moving. Suggestions for Adidas: -More colors (at the minimum black) -A bit more reinforced stitching on the Velcro lock system March 30, 2011
Rated 5 out of 5Â by Chestie adiZero SpeedWrap Ankle Brace Breathability: 8.5/10 The breathability of this ankle wrap really surprised me. Most ankle braces make my ankle sweat and hot, but with the adiZero construction it made my ankle cooler. And the coolness leading to better performance on the court. Ankle Support: 9.5/10 These ankle brace's ankle support are outstanding. Not just some fabric that you throw together and call a ankle brace, but this brace is built tough. A hard shell on the outside bone of your ankle prevents any hyperextension. I would say this ankle support is more of a preventer that a healing brace. Fit: 8/10 The fit of this ankle wrap, to me, was a little more on the tighter side. I wear a size 10.5 and thought I would get a size M brace, that might be my mistake. But the tightness turned out to my advantage a bit. Material: 8.5/10 The adiZero material is great, one of my all time favorites of adidas shoes. The brace feels like it would stand up to a lot of abuse. However, once worn a lot, it could develop visible fold creases which might not look that attractive. Longevity: 8.5/10 This brace would definitely last me a long time build on it's construction. adidas products have always been a first for me. Hope this review helped some of you! September 12, 2012
Rated 5 out of 5Â by Suh jr. Speedwrap So how about you just buy the wrap ... Seriously this is a great wrap and its not just for Basketball players. I'm a defensive tackle in high school and i sometimes tweak my right ankle when i tackle. So i bought the wrap. My ankle had been swollen, but when i put it on the swelling went down and i could cut better. I have not put it on in my Derrick rose 2.5's but i have in the crazy lights and it feels like nothings there. Being the fact that it saved me from serious injury i highly recommend this product...ps ADIDAS RULE!!! March 21, 2012
Rated 5 out of 5Â by SwooshSensei Impressive protection and impeccable performance My only concern is putting them in the washer. I know they built this brace with machine washable materials but I hope the TPU chassis stays intact and holds its strength in longevity. Ever since I've rolled my ankles cutting through the lane and rapidly changing directions, I knew how important sprain prevention would play a role in maintaining my crossover. Now with this speedwrap ankle brace I have more confidence to cut hard and finish at the rim. Overall great product, I'm very pleased with the performance. Happy Hoopin'! June 22, 2012
Rated 5 out of 5Â by Teagle McTeag These ankle braces are the bomb I generally play point guard and I'm very active in the paint. These ankle braces are the best braces that i've ever worn, and i've tried a good amount of other ankle braces in a range of different style. I wouldn't recommend these for anyone that is currently suffering from an ankle injury, otherwise I think that these braces are easily the best on the market especially at the price. I've suffered from many sprained ankles and despite wearing other braces as well as high top sneakers I still managed to roll my ankle. I decided to get these because I figured, if they're good enough for D.Rose they should definitely be good enough for me. It didn't take long after I got these on my feet and started playing that I soon forgot I was even wearing them, however I felt much more support on my ankles exactly where I needed it and nowhere that I didn't allowing for optimal mobility, a problem that plagues a majority of other braces. Another thing the Speedwrap has on most braces is their thin profile, they fit snug and close to the ankle unlike many other bulky braces that restrict movement. Right now I'm wearing these with Jordan 7's but I'm thinking about picking up a pair of the Rose 2.5's. Regardless. you need these ankle braces. End of story. March 13, 2012


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Rap-metal duo Insane Clown Posse is known for its scary clown make-up and elaborate, theatrical con...
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Once Warner Bros. announced that the sequel to this
Summer's "Man Of Steel" would feature Batman, a lot
of names were being thrown out as possibilities to play the Dark Knight.
You can stop the speculation 'cause Ben Affleck is officially
on board for the film, scheduled for release July 17th, 2015.
Warner Bros. had said they wanted a "mature" actor for the movie.
The film's director, Zack Snyder, said in a press release..."He
has the acting chops to create a layered portrayal of a man who is older and
wiser than Clark Kent and bears the scars of a seasoned crime fighter, but
retain the charm that the world sees in billionaire Bruce Wayne. I can't wait
to work with him."
Ironic point of interest #1: Affleck's been down the Super Hero road before. He played Daredevil back in 2003. That particular adaptation didn't exactly sit well with critics, or audiences, or me. It was pretty bad.
Ironic point of
interest #2: Affleck played George Reeves, TV's Superman, in
"Hollywoodland" in 2006. His co-star in that movie was Diane
Lane, who...wait for it...will return in the "Man Of Steel" sequel as
Clark Kent's Mom.
Here's my 2 cents..I don't think Ben Affleck is the right choice, he just doesn't have enough darkness in him to play the Dark Knight. Let's be honest, he always comes off a little smug, and Batman isn't smug.
Which leads me to the question: Who SHOULD play Batman? I have 2 front runners.
Josh Brolin - His name was popping up on message boards and I thought "I could see that". He could easily play the gruff, older version of the caped crusader.
Liev Schreiber - Yes, I know...he was Victor Creed/Sabretooth in Marvel's "X-Men Origins: Wolverine" BUT look at the guy. He's the right age to play an elder Batman (45), he's pretty physically imposing at 6'3". Most importantly, he's got the right level of gravitas needed for what will be Batman's role in the film. If you don't agree with me, maybe this will help. Who would win in a fight: Ben or Liev?


text:
Sheep & Goat Research Journal
Volume 29, 2014
High Frequencies of the αS1-Casein Zero Variant in Milk from Swedish Dairy Goats
Effects of Sex, Breed, Callipyge Phenotype, and Docked Tail Length on Rectal Prolapse in Lambs
Volume 28, 2013
Efficacy of Pregnancy-Specific Protein B Assay to Detect Pregnancy and Lambing Rates in Sheep
Growth and Performance of Meat Goat Kids from Two Seasons of Birth in Kentucky
Tail Length at Docking and Weaning of Lambs
Accuracy of Ultrasonographic Diagnosis of Sex and Effect of Sex and Birth Type on Biparietal Diameter of Saanen Goat Fetuses
Technical Note: Effects of Supplementation of Expired Human Foodstuffs on Intake and Digestion of Wethers Fed a Base...
Volume 27, 2012
Post-Natal Skin Follicle Development in The Raieni Cashmere Goat
Effectiveness of Theobromine and Caffeine Mixtures in Coyote Lure Operative Devices as a Predacide: A Simulated Field Study
Efficacy Of Garlic Juice, Copper Oxide Wire Particles, And Anthelmintics To Control Gastrointestinal Nematodes In Goates
Research Symposium Utilization of Genomic Information for the Sheep Industry
Performance of Meat Goats Control-Grazed on Winter Annual Grasses
Effects of Supplemental Dried Distillers Grains or Soybean Hulls on Growth and Internal Parasites Status of Grazing Lambs
Volume 26, 2011
Mixed Grazing Goats With Cattle on Reclaimed Coal Mined Lands in the Appalachian Region: Effects on Forage Standing Biomass,
Effects of Season of Kidding on Doe Performance in Commercial Boer Cross Does
Sulfur Intake, Excretion, and Ruminal Hydrogen Sulfide Concentrations in Lambs Fed Increasing ...
Growth and Carcass Characteristics of Conventionally Raised Lambs Versus Naturally Raised Lambs
Effects of Rumen-Protected Arginine Supplementation on Ewe Serum-Amino-Acid Concentration...
Volume 25, 2010
A Review: The Use of Livestock Protection Dogs in Association with Large Carnivores in the Rocky Mountains
Effect of Feeding System on Meat Goat Growth Performance and Carcass Traits
Effects of Supplemental Cobalt on Nutrient Digestion and Nitrogen Balance in Lambs Fed Forage-based Diets
Evaluation of Ultrasonography to Measure Fetal Size and Heart Rate as Predictors of Fetal Age in Hair Sheep
Effects of Human Chorionic Gonadotropin on Serum Progesterone Concentration During the First Weeks After Mating, Components of Pre-implantation Complete Blood Counts, and Number of Offspring...
Effect of Finishing Crossbred Meat Goats with a Similar Total Quantity of Finisher Ration Over Variable Duration
Protein Supplementation of Low-quality Forage: Influence of Frequency of Supplementation on Ewe Performance and Lamb Nutrient Utilization
Can Sheep and Cattle Rumen Microorganisms be Conditioned to Invasive Weeds?
Substituting Corn Dried Distillers Grains for Cottonseed Meal in Lamb Finishing Diets: Carcass Characteristics, Meat Fatty Acid Profiles, and Sensory Panel Traits
Feedlot Performance, Carcass Characteristics, and Muscle CLA Concentration of Lambs Fed Diets Supplemented with Safflower Seeds and Vitamin E
Pregnancy rates after ewes were treated with estradiol-17β and oxytocin
Manipulating Sheep Browsing Levels on Coyote Willow (Salix exigua) with Supplements
Effects of Physical Isolation on Serum and Salivary Cortisol and Components of Complete Blood Counts in Yearling Ewes
Research Note: Sheep Antiserum as an Antibody Supplement in Newborn Lambs
Volume 24, 2009
Effect of Expected Peripheral Concentrations of Progesterone on Ovulation Rate and Litter Size in Barbados Blackbelly Ewes
Post-weaning Management of Lambs Alters Subsequent Feedlot Performance and Tissue Deposition
Substituting distillers dried grains for cottonseed meal in lamb-finishing diets: growth, wool characteristics, and serum NEFA, urea N, and IGF-1 concentrations
Wool Price Differences by Preparation in the United States
Evaluating Nutritional Status of Dorper and Rembouillet Ewes in Range Sheep Production
Volume 23, 2008
Feeding of DDGS in Lamb Rations
Nutrient Utilization in Polypay and Percentage White Dorper Lambs Fed a High-Roughage and a High-Concentrate Diet
PRNP Genotype and Sale Price - Associations of prion protein genotype with sale price in a flock of purebred Polled Dorsets
The Yellowing Propensity of Rambouillet Wool
Volume 22, 2007
Winter Grazing Systems for Gestating Ewes
Cash Versus Contract Marketing in the U.S. Lamb Industry
Superovulation in Sheep: Number and Weight of the Corpora Lutea and Serum Progesterone
Western Snowberry Response to Fire and Goat Browsing
Growth and Carcass Characteristics in Goat Kids Fed Grass- and Alfalfa-Hay-Based Diets with Limited Concentrate Supplementation
Peanut Stover and Bermudagrass Hay for Wethers on Summer Hardwood Rangeland in North Central Texas
Weaning Weights in a Range Purebred Merino and Crossbred Merino x Rambouillet Flock
Volume 21, 2006
Corn Supplement for Goats on Summer Rangeland or Improved Pasture
Development and Consumer Acceptance of Pre-cooked Goat Roasts
Efficacy of Dried Distiller's Grains with Solubles as a Replacement for Soybean Meal and a Portion of the Corn in a Finishing Lamb Diet
Development and Consumer Acceptance of Pre-cooked Lamb Leg Roasts
The Color of Scoured and Carded Wools: A Comparison of U.S., Australian and New Zealand Wools
Sexual Performance and Reproductive Characteristics of Young Adult Awassi, Charollais-Awassi and Romanov-Awassi Rams
Stocking Rates on Cultivated Winter Pastures for Meat Goats
Browsing of Western Snowberry by Goats and Sheep
Volume 20, 2005
Seasonal Acceptance of Fourwing Saltbush by Sheep When Crested Wheatgrass is the Alternative
Feedlot Performance and Carcass Characteristics of Lambs Sired by Texel, Romanov, St. Croix or Dorset Rams from Polypay and St. Croix Ewes
Cost of a Maedi Visna Flock Certification Program and the Changes in Productivity and Economic Return
Post-weaning Growth and Carcass Traits of St. Croix White and Dorper X St. Croix White Lambs Grazing Pasture During the Dry and Wet Seasons in the U.S. VI
Post-weaning Growth and Carcass Traits of St. Croix White and Dorper X St. Croix White Lambs Fed a Concentrate Diet in the U.S. Virgin Islands
Growth Performance of Barbados Blackbelly, Katahdin and St. Croix Hair Sheep Lambs Fed Pasture- or Hay-based Diets
Gastrointestinal Parasitism in Hair Sheep and Meat Goat Breeds Grazing Naturally Infected Pasture
Carcass and Growth Characteristics of Wethers Sired by Percentage White Dorper or Hampshire Rams 1
Postweaning Performance of Hair and Wool Sheep and Reciprocal-crosses on Pasture and in Feedlot
Lamb Production of Dorper, Katahdin, and St. Croix Bred in Summer, Winter, or Spring in the Southeastern United States
Volume 19, 2004 -Special Edition: Predation
Review of Canid Management in Australia for the Protection of Livestock and Wildlife - Potential Application to Coyote Management
The Coyote in the Edwards Plateau of Texas -- an Update
Predation and Livestock Production Perspective and Overview
Economic Impact of Sheep Predation in the United States
The History of Federal and Cooperative Animal Damage Control
Status and Management of Coyote Depredations in the Eastern United States
Coyote Predation Management: An Economic Analysis of Increased Antelope Recruitment and Cattle Production in South Central Wyoming
Feral Swine Impacts on Agriculture and the Environment
Managing Wolf Depredation in the United States: Past, Present, and Future
Compensation Programs in Wyoming for Livestock Depredation by Large Carnivores
Direct, Spillover, and Intangible Benefits of Predation Management
Livestock Depredations by Black Vultures
Indirect Effects of Carnivores on Livestock Foraging Behavior and Production
Non-lethal Alternatives for Predation Management
Use of Livestock Guarding Animals to Reduce Predation on Livestock
Predacides for Canid Predation Management
Selective Targeting of Alpha Coyotes to Stop Sheep Depredation
Economic Impact of Protected Large Carnivores on Sheep Farming in Norway
Using Genetic Analyses to Identify Predators
Volume 18: 2003
Case Report - Monensin Poisoning in a Sheep Flock
Research Note - Repeated Injections of Pregnant Mare Serum Gonadotrophin (PMSG) Failed to Induce Antibody Production in Fall Lambing Ewes
Effects of Supplementing Ewes with d-a-Tocopherolon Serum and Colostrum Immunoglobulin G Titers and Preweaning Lamb Performance
Effects of the FecB Gene in Half-sib Families of Rambouillet-cross Ewes
Potential Associative Effects of Increasing Dietary Forage in Limit-fed Ewes Fed a 6% Fat Diet
Interrelationships of Traits Measured on Fine-wool Rams During a Central Performance Test
Effects of Supplementing Polyethylene Glycol to Goat Kids Grazing Sericea Lespedeza and Early Post-weaning Nutritive Plane Upon Subsequent Growth
Use of DNA Markers to Determine Paternity in a Multiple-Sire Mating Flock
Use of the Lamb Vision System to Predict Carcass Value
Quebracho Tannin Influence on Nitrogen Balance in Small Ruminants and In-Vitro Parameters when Utilizing Alfalfa Forage
An Investigation into the Risk Factors Associated with Clinical Mastitis in Colorado Sheep
Weight Changes in Fall and Spring Lambing Ewes Grazing Fallow Wheat Fields During the Summer
Effect of Ethanol Supplementation on In Vitro Digestion and VFA Production and Growth Performance of Newly Weaned
Growth and Reproductive Performance of Ewe Lambs Implanted with Zeranol after Weaning, but before Sexual Maturation
Consumer Evaluation of Pre-Cooked Lamb
Caprine Arthritis-Encephalitis: An Update
An Evaluation of Different Energy Supplements for Lambs Consuming Endophyte-free Tall Fescue
The Effects of Energy Source and Ionophore Supplementation on Lamb Growth, Carcass Characteristics and Tenderness
Comparing Indicators of Sheep Grazing Leafy Spurge and Perennial Grasses
Volume 17, No. 3: 2002 -- Special Issue: Breeding for Meat Production
Fundamental Aspects of Crossbreeding of Sheep: Use of Breed Diversity to Improve Efficiency of Meat Production
Use of Finnsheep Crosses in a Western Commercial Sheep Operation
Composite Trait Selection for Improving Lamb Production
Relationships Among Traits: Growth Rate, Mature Size, Carcass Composition and Reproduction
Strategies for Genetic Improvement of Carcass Value in Lambs
Opportunities to Reduce Seasonality of Breeding in Sheep by Selection
Genetic and Environmental Impacts on Prenatal Lamb Loss
Selection for Reproductive Efficiency
Volume 17, No. 2: 2002
Research Note - Influence of Supplement Form on Ewe Performance and Reproduction
Technical Note - Genetic Control of Color in Dorper Sheep and Their Crosses
Adipose Tissue Lipogenic Enzyme Activity, Serum IGF-I, and IGF-Binding Proteins in the Callipyge Lamb
Effect of Colostrum Intake on Serum Hormone Concentrations and Immunoglobulin G Absorption in Neonatal Lambs
Scrapie in Sheep: A Transmissible Spongiform Encephalopathy
Fall and Winter Grazing of Brassicas - a Value-Added Opportunity for Lamb Producers
Effects of Prenatal Shearing of Ewes on Birth Weight and Neonatal Survivability of Lambs
Volume 17, No. 1, 2001
Special Issue: 1994 -- The Role of Sheep Grazing in Natural Resource Management
The Role of Sheep and Sheep Products in Waste Management
Sheep: A Method For Controlling Rangeland Weeds
Sheep as a Silvicultural Management Tool in Temperate Conifer Forest
Sheep Grazing as a Brush and Fine Fire Fuel Management Tool
Prescribed Sheep Grazing to Enhance Wildlife Habitat on North American Rangelands
Sheep Grazing as a Range Improvement Tool
Sheep Grazing and Riparian and Watershed Management
Multispecies Grazing: The Ecological Advantage


text:
Adams Papers Indexes | Adams Papers, Cumulative Index to volumes published through 2006 | B | Bingham, Hon. Lavinia (Countess Spencer)
23d. [Diary of John Quincy Adams 1:255]+
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When you imagine a hospital room, a blow-up pool probably doesn't come to mind. But that's exactly what you'll find inside some of the labor and delivery rooms at Atlanta Medical Center. That's where a small but growing number of women are choosing to give birth in water.Kristen Ritter-Rivera spent months getting ready for her baby Diego's birth last November, she wanted his arrival to be warm and natural.She didn't want to give birth in a hospital bed; she wanted to do it in water."We're water beings, we live on a water planet. It's just seemed natural to be in the water," Ritter-Rivera said. Nurses and midwives at Atlanta Medical Center delivered on Ritter-Rivera's birth plan.As she moved through the first stages of labor, they set up a "birth pool in a box"in her hospital room, filling it with hot water that was close to 100 degrees.Certified Nurse Midwife Marsha Ford says it feels like it does when you take a hot bath at home, and this is how about 10 percent of her patients want to deliver their babies."A lot of women do not want to lay in the bed. They do not want to stay connected to monitors. They want to be up and moving. They do not want IVs," Ford said. Ritter-Rivera was 9 centimeters dilated before she actually climbed into the pool. A woman usually starts pushing at 10."And I tell you, as soon as I sat in that water, it was just like -- everything relaxed," Ritter-Rivera said.
The nurses use waterproof monitors and equipment to make sure Diego's heartbeat was stable.""If you see that you have a problem, then you can get the woman out of the pool. If you need a physician, you can call a physician for your backup," Ford said. Ritter-Rivera had no complications. "I was finally like, 'Ah, relief,'" said Ritter-Rivera. She only pushed for about 40 minutes."And when he finally came out, I felt the ring of fire, I felt all my bones, you know, push out of the way. And it was like one last push and got his head through and his body just ejected out," Ritter-Rivera said.Because Diego went from a warm womb to warm water, he was calm when he was born."He was just so wide-eyed and alert and looking around," Ritter-Rivera said. "They don't come out screaming and hollering. You will not see a screaming hollering water baby. You will not," Ford said. Kristen says Diego's birth turned out to be like her baby -- better than she could have ever imagined."It was beautiful; it was a perfect, perfect, perfect birth. I highly recommend it. I would do it over again in a minute. Hopefully I will be able to do it again," Ritter-Rivera said.Atlanta Medical Center and North Fulton Medical Center are the only hospitals offering water birth deliveries. You have to take a class at Atlanta Medical Center before you can deliver via water birth.Ford says there's no additional charge and the deliveries are covered by Medicaid and most health insurance providers.So, would you try it? Weigh in on Beth Galvin's Facebook page.
The FOX Medical Team's Beth Galvin shows us new tactics doctors are trying, to help patients tackle anxiety.
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