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GREY'S ANATOMY - "Here's to Future Days" - Alex asks Derek what he would do if Meredith were sick and a risky surgery was the only thing that could save her, on "Grey's Anatomy," THURSDAY, MAY 14 (9:00-11:00 p.m., ET) on the ABC Television Network.
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(Reuters) - Delta Air Lines
The order for the 76-seat CRJ900 aircraft comes as Delta, the No. 2 airline behind United Continental
The orders were valued at $1.85 billion, with that rising to $3.29 billion should the options be exercised, Bombardier said.
Shares of rival Brazilian jet maker Embraer SA
Bombardier won its biggest jet deal of $7.8 billion from Swiss charter operator VistaJet for up to 142 global aircraft last month.
Delta's feeder carriers currently fly Bombardier 466 CRJ Series planes.
The Canadian aircraft and train maker's stock is trading at about 8 times analysts' expectations for 2012 earnings, according to Thomson Reuters data. By contrast, Boeing
Bombardier shares were up 2 percent.
Benoit Poirier, a Desjardins analyst, said in a note to clients that the Delta and VistaJet deals were expected to bring Bombardier's regional aircraft backlog to a record level of more than $60 billion by the end of the fourth quarter.
"Additionally, we believe there is further momentum ahead for Bombardier's regional segments as Garuda (of Indonesia) is expected to place a large order for turboprops," Poirier wrote on Thursday. Longer term, he added, there could be opportunities for orders from regional carrier SkyWest
Atlanta-based Delta has taken a number of moves to revamp its fleet used on U.S. routes with an eye to eliminating less-efficient planes and adding more first-class cabins that appeal to business passengers.
Earlier this year, it reached an agreement to add 88 Boeing
Delta said on Thursday it expects to start taking delivery of the Bombardier and Boeing planes in the latter half of 2013.
Shares of Delta were up 2.1 percent at $9.92 on the New York Stock Exchange in late morning trade.
(Reporting by Krithika Krishnamurthy in Bangalore, Brad Haynes and Cesar Bianconi in Sao Paulo and Karen Jacobs in Atlanta; Editing by Joyjeet Das and Leslie Gevirtz)

subset: commoncrawl


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Whoops! Sorry about that. It looks like you found a page that doesn't exist (404)
We make 100's and even 1000's of links on our websites and occasionally one gets lost or broken. The forecast for finding this page is not so good. Take a look at your 7 Day Forecast Instead..


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Every once in a while I engage in an experiment. One that has failed miserably is the aging of some mid-late '90s Gallo of Sonoma Single Vineyard Cabs. In the last year or two I have opened multiple bottles of the '97 Barelli and Frei Cabs to universal disgust.
Last night it was the '97 Gallo of Sonoma Frei Ranch Cabernet Sauvignon that was fatally oxidized (orange at the rim), and smelling/tasting of nothing so much as rotting leaves and stewed fruit. Since this has been pretty universal I chalk it up to wine that couldn't age, but perhaps it was cooked somewhere. I don't know.
So I then opened the 2001 Chateaux Kirwan (Margaux). I was immediately assaulted by a huge dose of dar roast coffee. Initially dismayed I let the glass sit for an hour. Returning to it the coffee has toned down, and red and black cherry emerged with good minerality and still some very toasted oak on the finish. There's a lot of fruit here, but I don't know if it will ever totally integrate the oak. I will leave my other bottles for several years and hope.


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Brain Cancer Study Explores Multi-Targeted Therapies
Targeted drugs such as imatinib (Gleevec) and erlotinib (Tarceva) have been tested against brain cancer, but few patients have benefited. A new study offers a possible explanation for the disappointing results and suggests that using the drugs in combination may be a more effective strategy against the deadly disease.
On Friday, September 14, 2007, the cancer community lost one of its truly outstanding leaders. Dr. Martin Abeloff, who directed the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University for the last 15 years, died after a year-long battle with leukemia.
He was among the finest clinician/researchers I have ever met. His legacy will be marked by his personal success as a leader in translational research, particularly with regard to the adjuvant treatment of breast cancer. Dr. Abeloff also was a proponent of cancer prevention and control research, establishing a formal program at Kimmel for research in early disease biomarkers and disease surveillance.
Brain Cancer Study Explores Multi-Targeted Therapies
Targeted drugs such as imatinib (Gleevec) and erlotinib (Tarceva) have been tested against brain cancer, but few patients have benefited. A new study offers a possible explanation for the disappointing results and suggests that using the drugs in combination may be a more effective strategy against the deadly disease.
The researchers found that brain cancer cells may simultaneously activate a number of proteins on the cell surface called receptor tyrosine kinases, or RTKs. These proteins relay growth-promoting signals into cells, sustaining their survival. RTKs have become popular drug targets because they are frequently overactive or mutated.
By simultaneously turning on a number of RTKs, cancer cells may reduce their dependence on any one, and thereby improve their chances of survival, the researchers reported online in Science on September 13. They first observed the phenomenon in cells from patients with glioblastoma and then in other major cancers.
"We have found that a number of RTKs are simultaneously activated in virtually all the cancer cells we've examined," says Dr. Ronald DePinho of the Dana-Farber Cancer Institute, who led the study. "When one is blocked another can step in and sustain the survival signal."
What may matter most in treating the disease is to reduce the overall level of these abnormal signals in cells, he adds.
The findings support the growing view that some RTKs are more or less interchangeable, and they may help explain the feeble clinical responses when RTK inhibitors are used against solid tumors, the researchers say. Even when the drugs elicit an initial response, most cancers eventually progress and patients need additional therapies.
Glioblastoma is usually fatal within a year of diagnosis. More than 100 clinical trials over the last decade have not improved survival, with brain cancer, with the notable exception of temozolomide (Temodar) for a subset of glioblastoma patients. The lack of progress stems from not knowing which genes are involved in the disease.
Dr. DePinho and his colleague Dr. Jayne Stommel were searching for RTKs that drive glioblastoma when they uncovered the multiple coactivated RTKs. Some of the kinases, such as EGFR and Met, were known to play a role in the disease, but others were not.
Researchers may need to look more globally at RTKs that work in conjunction with known factors such as EGFR, says Dr. John Laterra, a brain cancer researcher at Johns Hopkins Medical School.
This study is timely because many scientists are looking at the networks of RTKs and the pathways they control," Dr. Laterra continues, "and they are finding evidence of close crosstalk and interplay among the pathways."
In the study, three or more targeted drugs were typically needed to control abnormal cell growth. The researchers used an experimental Met inhibitor in combination with imatinib and erlotinib to block the flow of growth signals into cells and cause them to die. They confirmed the results using RNA interference to inhibit the RTKs.
Like many in the field, the researchers envision an individualized approach to cancer therapy. Patients would have their tumors profiled to see which RTKs are active, and a regimen would be designed based on the results.
A number of RTK inhibitors have been approved for cancer and others are in development. But the first Met inhibitors, for instance, are still in early-stage clinical testing. The costs and toxicities associated with using multiple targeted drugs would need to be addressed before clinical trials could be launched.
Nonetheless, if the basic hypothesis is confirmed by other studies, researchers will have to rethink how trials for glioblastoma and other solid tumors are designed, says Dr. Antonio Omuro of the Hôpital Pitié-Salpêtrière in Paris, who coauthored a recent commentary on targeted therapy for brain cancer.
"We will need to reinforce the policy of molecularly profiling every single patient enrolled in clinical trials," he says. "We have not always done this, but everyone knows that it is essential to move the field forward."
—Edward R. Winstead
In Memory of Dr. Martin Abeloff
He was among the finest clinician/researchers I have ever met. His legacy will be marked by his personal success as a leader in translational research, particularly with regard to the adjuvant treatment of breast cancer. Dr. Abeloff also was a proponent of cancer prevention and control research, establishing a formal program at Kimmel for research in early disease biomarkers and disease surveillance.
The tremendous achievements of the researchers, clinicians, and other staff at Hopkins over the past decade and a half are a tribute to Dr. Abeloff's tremendous abilities as a champion of cancer research and all it can accomplish. It was those strong beliefs that allowed Dr. Abeloff and his colleagues to attract the support needed to build a world-class research and treatment facility that encourages and fosters collaboration and excellence.
Despite his many responsibilities, Dr. Abeloff generously volunteered his considerable expertise, particularly at NCI, where he served for more than 10 years on various advisory boards and panels, including as chair of the Board of Scientific Counselors and as a member of the Advisory Committee to the Director.
In 1994, Dr. Abeloff gave the keynote address at the American College of Surgeon's "Commission on Cancer" meeting, outlining his thoughts on professionalism and cancer care. "Values essential to medical professionalism are honesty and integrity," he said. "The professional physician has an attitude of humility as well as accountability to patients, colleagues, and society."
Rarely do individuals ascend to the lofty standards they discuss in forums such as this. But that could never be said of Dr. Abeloff. His honesty and integrity were unparalleled. Former NIH director and current president of the Memorial Sloan-Kettering Cancer Center Dr. Harold Varmus described him well, calling Dr. Abeloff a man who "knew how to criticize without insult and praise without flattery."
Dr. Abeloff never forgot that patients are people, and that his hospital's responsibility was to treat the whole patient. From that belief arose the Art of Healing program at Kimmel, through which patients get to enjoy original works of art and musical performances, providing moments of serenity during a time often overflowing with anguish.
In a Washington Post article on Dr. Abeloff's death, a former patient recounted how 17 years ago, Dr. Abeloff helped to allay her fears about her pending treatment. He also gave her a small piece of torn paper with his phone number on it - he didn't have a business card - telling her to call him any time. Humble and accountable, indeed.
The remarkable outpouring of kind words and accolades from colleagues, former patients, and friends in the wake of his untimely passing is no surprise. He was a man who touched countless lives.
I'd like to offer the heartfelt condolences - and the eternal gratitude - of the entire NCI to Dr. Abeloff's family. He was a rare person, one who continually gave of himself, who believed in the constant pursuit of knowledge and excellence, and whose impact will continue to be felt for decades to come. As a very close friend and professional colleague, I will dearly miss him.
Dr. John E. Niederhuber
Researchers have identified a small subset of genes whose activity could predict high-risk cases of multiple myeloma and potentially guide therapy decisions in the future. They presented their data recently at the American Association for Cancer Research's second International Conference on Molecular Diagnostics in Cancer Therapeutic Development. NCI provided partial funding for the study.
The investigators, from the Myeloma Institute for Research and Therapy at the University of Arkansas for Medical Sciences, followed 532 multiple myeloma patients for 7 years after a blood stem cell transplant to create a genetic profile to chart the severity of the disease. The team determined that the activity of as few as 17 genes could mean the difference between high or low risk for a poor prognosis. About 30 percent of the genes that predict high risk are found on chromosome 1.
In addition, around 13 percent of all the patients they studied exhibited a genetic pattern that fit into the high-risk category, a frequency that rose to 76 percent among relapsed patients. An increase in the gene-expression risk score among relapsed patients provides evidence that there are likely to be small subsets of high-risk cells even in patients with low-risk disease, and that current therapeutics are suboptimal in that they kill off the low-risk cells, leaving behind cells that exhibit a high-risk genetic profile. "Gene expression profiles have now provided us with signposts that help us risk-stratify patients and tailor therapies accordingly," said lead researcher Dr. John D. Shaughnessy, Jr.
Bortezomib Multiple Myeloma Trial Halted after Analysis Shows Significant Survival Improvements
A phase III trial testing bortezomib (Velcade) plus the combination of two chemotherapy drugs for the first-line treatment of patients with newly diagnosed multiple myeloma has been stopped early based on recommendations of the trial's independent data monitoring committee (IDMC) so patients in the control arm can be switched over to the bortezomib treatment arm.
Millenium Pharmaceuticals, which manufactures bortezomib, announced last week that the IDMC halted the 682-patient trial, dubbed VISTA, after a planned interim analysis showed that the combination of bortezomib with melphalan and prednisone demonstrated a highly statistically significant improvement in overall survival and progression-free survival, as well as time-to-disease progression and complete remission rate compared with melphalan and prednisone alone.
"These results position [bortezomib]-based therapy as a new standard of care for newly diagnosed multiple myeloma patients," Dr. Paul Richardson, clinical director of the Jerome Lipper Multiple Myeloma Center at the Dana-Farber Cancer Institute and one of the trial's lead investigators, said in a statement.
During a conference call with investors and media, Millenium representatives said data from the analysis will be presented in December at the American Society of Hematology annual meeting. Dr. Nancy Simonian, Millenium chief medical officer, did say, however, that the results were consistent with those from a similar phase II trial presented in June at the International Myeloma Workshop in Greece, which showed a 43-percent complete response rate and a 3-year survival rate of 85 percent.
New FOBT Promising for Detection of Colon Cancer
In a large prospective study performed by investigators from three Northern California Kaiser Permanente medical centers, a type of fecal occult blood test (FOBT) called a fecal immunochemical test (FIT) showed high sensitivity and specificity for detecting left-sided colorectal cancer. The results were published in the September 25 Journal of the National Cancer Institute.
The investigators enrolled 7,394 eligible Kaiser Foundation Health Plan members aged 50 or older without a personal or family history of colon cancer into the study. All participants collected stool samples for use on three test cards, and the samples on each test card were used for three tests: a sensitive unrehydrated guaiac test (GT, a more sensitive version of the current standard FOBT), the FIT, and a combination of those two tests. Out of all participants, 5,841 prepared cards correctly and had at least 1 usable test result. Of these, 11 percent had at least 1 positive result.
Investigators recommended that all participants testing positive on the FIT or combination tests undergo colonoscopy, and all participants testing negative undergo sigmoidoscopy. Because most participants tested negative and underwent sigmoidoscopy, which can only visualize the left colon, only detection of left-sided colorectal cancer could be compared between tests. All participants were followed for 2 years, until diagnosis of a colorectal neoplasm, or until death, whichever came first.
The FIT had an 81.8 percent sensitivity for detecting colorectal carcinoma, and a 29.5 percent sensitivity for detecting advanced colorectal adenomas (noncancerous tumors). Specificity was 96.9 percent for carcinomas and 97.3 percent for adenomas, which increased to 98.1 percent and 98.4 percent in the combination test.
Although the investigators did not directly compare the FIT test with the current standard FOBT test, other recent comparisons have shown its superiority, they explain. "The FIT has high sensitivity and specificity for detecting left-sided colorectal cancer," they conclude, "and it may be a useful replacement for the [current standard test]."
FDA Approves Raloxifene for Breast Cancer Prevention
There are now two drugs approved for the prevention of breast cancer, after the U.S. Food and Drug Administration (FDA) last week approved raloxifene (Evista) to reduce the risk of invasive breast cancer in postmenopausal women at high risk of the disease. The new approval also covers raloxifene to reduce the risk of invasive breast cancer in postmenopausal women with osteoporosis.
Leading prevention researchers called the approval an important moment for women at high risk of breast cancer.
"I am excited that postmenopausal women at increased risk for breast cancer now have a choice of drugs to reduce their risk," says Dr. Leslie Ford, associate director for clinical research in NCI's Division of Cancer Prevention. "Women and their doctors are already familiar with raloxifene and should be comfortable using it for both breast cancer and osteoporosis prevention."
The agency's action follows recommendations in August by the FDA's Oncology Drugs Advisory Committee to approve the drug for both indications.
In a statement, Dr. Steven Galson, director of the FDA's Center for Drug Evaluation and Research, advised women at high risk of breast cancer to discuss raloxifene's risks and benefits with their physicians to determine "whether the drug is right for them."
Positive results from four different clinical trials formed the basis for the agency's approval of raloxifene, which was initially approved to prevent and treat osteoporosis in postmenopausal women.
Included among those was a pivotal, NCI-supported trial known as STAR, which demonstrated that raloxifene was as effective as tamoxifen - the first drug approved for breast cancer chemoprevention - at reducing breast cancer risk in postmenopausal women. In the trial, raloxifene was generally less toxic than tamoxifen, but it was not as effective at reducing the risk of a noninvasive condition that can be a precursor to cancer, known as ductal carcinoma in situ, or DCIS.
In the STAR trial, both raloxifene and tamoxifen reduced the risk of invasive breast cancer by approximately 50 percent. Women on raloxifene had a reduced risk of blood clots, endometrial cancer, and cataracts compared with women on tamoxifen, although not all were statistically significant reductions.The three other clinical trial results the FDA took into consideration were the CORE, MORE, and RUTH trials. Although breast cancer risk reduction was not a primary endpoint for any of the trials, all three did demonstrate a significant risk reduction in women given raloxifene.
In 2003, finasteride became the first drug to prevent prostate cancer in a large, prospective study, the Prostate Cancer Prevention Trial (PCPT). Finasteride reduced the overall occurrence of prostate cancer by 25 percent, but concerns were raised because men taking the drug had a slightly higher number of high-grade prostate cancers, which tend to be aggressive. Two studies in the September 19 Journal of the National Cancer Institute provide reassurance that the drug was probably not causing the high-grade cancers. Rather, finasteride may have simply made it easier to detect high-grade cancers. Dr. M. Scott Lucia of the University of Colorado Health Sciences Center, who coauthored the PCPT results and led one of the new studies, discusses the findings.
What did you learn from your study?
Have the new findings changed your view of the PCPT results?
Are the results good news for men?
Targeting Blood Cancers at the Source
Recent identification of cells with stem cell-like properties in solid tumors including breast, brain, lung, and prostate cancer has generated considerable excitement in the cancer research community. Scientists now believe that these cells - which can both self renew to maintain the population of stem cells and produce more differentiated progenitor cells which make up the bulk of a tumor - may play a role in the formation, recurrence, and metastasis of many solid cancer types and present a target that must be eradicated to potentially produce a cure.
This research in solid tumors is only now beginning to accelerate, but investigators studying cancers of the blood have known about the existence of cancer stem cells in these malignancies for over a decade, and tactics for destroying stem cells in hematologic cancers have begun to make their way into early human trials.
Cancer stem cells are thought to be at the root of therapeutic resistance for many hematologic cancers. For example, chronic myelogenous leukemia (CML) responds to treatment with the targeted drug imatinib, but patients inevitably relapse when they stop taking the drug, and many patients' cancers progress even during treatment.
Researchers speculate that resistance of CML stem cells to imatinib is due to their quiescence, a state of relative dormancy where the cells do not divide, protecting them from both traditional chemotherapy, which targets rapidly dividing cells, and therapies such as imatinib that target cell-signaling pathways.
"Slow cycling [of cancer stem cells] is probably one of the biggest challenges that we face in terms of targeting for therapy," says Dr. John Dick, director of the Program in Stem Cell Biology at the University of Toronto, whose laboratory first identified cancer stem cells in acute myeloid leukemia in 1994.
One approach to addressing this challenge has been to "wake up" the cancer stem cells - to force them to divide and enter the cell cycle. This idea is being tested by the United Kingdom's National Cancer Research Network, whose GIMI trial is based on the observation that granulocyte-colony stimulating factor applied intermittently to leukemia stem cells in vitro could stimulate them to proliferate, thus increasing their sensitivity to imatinib.
This approach is also being tested at Johns Hopkins University. "We're trying to bring the immature stem cells to maturity, to induce them to differentiate into mature cells," explains Dr. Carol Ann Huff, assistant professor of oncology at Johns Hopkins, whose group is working with granulocyte-macrophage colony stimulating factor in conjunction with cell cycle inhibitors in both myelodysplasia and leukemia.
But Dr. Huff's clinical trials group is also looking at another tactic - taking advantage of the differences between cancer stem cells and "normal" cancer cells, "to actually eradicate the quiescent cancer cells" rather than bring them into the cell cycle, she explains.
"One of the things we've learned in leukemia and multiple myeloma is that agents that are active against the differentiated cells have little effect on leukemia or myeloma stem cells and vice versa," she says. "We believe that's part of the reason why we haven't been able to eradicate the stem cells with the current drugs that we have." Dr. Huff and her colleagues are now testing combination therapies with drugs known to reduce the bulk of circulating tumor cells - such as imatinib in CML or cyclophosphamide in multiple myeloma - and drugs with particular affinity for cancer stem cells, such as rituximab in multiple myeloma, which targets a protein expressed on the surface of the stem cells but not the bulk of the cancer cells.
Additional research into the unique molecular properties of cancer stem cells is needed, explains Dr. Dick, to advance such targeted treatment regimens. "We need to understand their properties," he says. "We need to understand what the mechanisms are that make them resistant to therapy, and...we need to understand the self-renewal mechanisms in these cells, because in the end that's the one property I think everyone would accept that a cancer stem cell has - the ability to renew itself in perpetuity. That's what makes the cancer stem cell so potent and really so different from the other cells in the tumor."
—Sharon Reynolds
New Chemo Agents Travel Winding Road
At a time when there is no shortage of studies that identify potential molecular targets for new cancer therapies and many pharmaceutical and biotechnology companies are banking on targeted cancer agents to ensure future success, cytotoxic chemotherapy still represents the foundation of treatment for the vast majority of cancers.
In fact, a number of pharmaceutical companies are busily developing new chemotherapeutic agents.
Among those under development, a class of drugs known as epothilones has generated intense interest because of promising results from preclinical studies and early-phase clinical trials, and because they work similarly to a class of highly effective chemotherapy drugs, the taxanes, but don't require premedication with steroids to fend off allergic reactions. In June, the U.S. Food and Drug Administration (FDA) granted priority review to Bristol Myers Squibb's application to market ixabepilone, the epothilone furthest along in clinical testing, for the treatment of metastatic breast cancer. Priority review means FDA intends to complete the review within 6 months.
In August, results of five phase II clinical trials testing ixabepilone were published in the Journal of Clinical Oncology (JCO) - four trials in metastatic breast cancer and one in advanced non-small-cell lung cancer (NSCLC). In all five trials, the drug showed comparable efficacy to what has historically been seen with the standard-of-care drugs, including taxanes such as paclitaxel and docetaxel, that are the cornerstones of treatment for metastatic breast cancer.
And, as important, it had what's considered an "acceptable" toxicity profile - one that produced toxicities that, although not negligible, were manageable and didn't prohibit the drug's use in most patients for long enough to provide a clinical benefit.
"The evidence to date on ixabepilone [to treat metastatic breast cancer] suggests that it is extremely effective either as a first-line therapy or after patients have undergone multiple treatments, especially with an anthracycline or after taxanes," explains Dr. Sandra Swain, medical director of the Washington Cancer Institute in Washington, DC, who has led several phase II trials involving ixabepilone.
Ixabepilone also produced favorable results in one of two ongoing phase III breast cancer trials in which it is being investigated, comparing it plus capecitabine to capecitabine alone in patients with metastatic breast cancer who have progressed after standard treatments. Presented at the American Society of Clinical Oncology annual meeting in June, the results of the trial were not staggering - a 1.5 month improvement in progression-free survival and a 2.5-fold increase in overall response rate - but the improvements compared favorably enough with the current standard to secure an FDA priority review.
Although they are not generally considered "targeted" drugs, most chemotherapeutic agents do have a target: rapidly dividing cells. In the epothilones' case, just like the taxanes and the vinca alkaloids, another class of chemotherapy agents, they target a component of cells' cytoskeleton known as microtubules, which are critical to cell division. All three types of agents work by stabilizing microtubules; this disrupts the process of cell division (and thus, further proliferation) and eventually leads to cancer cell death.
"We know the tubulins have been a good target," says Dr. Edith Perez, director of the Breast Cancer Program at the Mayo Clinic Jacksonville and investigator on one of the JCO-published ixabepilone trials.
But the epothilones, of which there are four being tested in phase II or III trials (see table), "appear to bind in a different location compared with other tubulin-targeting agents," she adds. That may explain why these drugs have shown activity in patients who have developed resistance to other tubulin-targeting agents like the taxanes.
That was the case in four of the five trials published last month in JCO (the fifth used ixabepilone as a first-line treatment). In the advanced NSCLC trial, ixabepilone demonstrated results comparable to those seen with three other drugs already FDA-approved for patients whose tumors are no longer responding to the first-line treatment.
And therein lies part of the difficulty for any new chemotherapeutic agent, notes Dr. Alan Sandler, medical director of Thoracic Oncology at Vanderbilt University and co-investigator on the trial.
"It's not like the old days where you didn't have anything for these patients," he says. "We now have three agents for second line, two chemotherapeutic and one targeted agent."
In the case of ixabepilone for the treatment of NSCLC, he says, it's still unclear where it can or will go from here. For example, there is potential in the second-line arena because
If approved by the FDA, Dr. Perez says, it appears as if ixabepilone at least would present new options. In the case of the phase II trial in which she was involved, for example, there is no approved therapy for the type of patients it enrolled, all of whom were resistant to anthracyclines, taxanes, and capecitabine.
"These patients are now treated with unapproved drugs," she notes, "so it was nice to demonstrate that ixabepilone has clear activity, thus addressing an unmet patient need."
Information from NCI's PDQ Cancer Clinical Trials Registry about epothilone clinical trials can be found at: Ixabepilone clinical trials, Patupilone clinical trials, and ZK-EPO clinical trials.
—Carmen Phillips
Pomegranate Juice for PSA-Only Prostate Cancer Recurrence
Name of the Trial
Principal Investigators
Why This Trial Is Important
Currently, there is no standard treatment for men who have recurrent prostate cancer detected by an increase in PSA level only. Consequently, doctors want to develop treatments that can slow down or reverse increases in PSA without causing serious side effects.
In this trial, researchers are exploring the potential of pomegranate juice to slow or reverse increasing PSA levels in men who have undergone treatment for localized prostate cancer. Pomegranate juice is rich in phytochemicals, substances that have been shown in laboratory studies to inhibit cancer growth and spread. Men in this trial will be randomly assigned to drink a special preparation of pomegranate juice or a placebo drink daily for up to 1 year.
"In a phase II trial we conducted, daily consumption of pomegranate juice resulted in a significant lengthening of PSA doubling time and disease stabilization," said Dr. Pantuck. "We hope to verify those results in a phase III, double-blinded, placebo-controlled study."
Who Can Join This Trial
Study Site and Contact Information
An archive of "Featured Clinical Trial" columns is available at http://cancer.gov/clinicaltrials/ft-all-featured-trials.
Following are newly released NCI research funding opportunities:
The Cooperative Human Tissue Network
This is a renewal of RFA-CA-01-009 and will use the U01 award mechanism. For more information, see http://cri.nci.nih.gov/4abst.cfm?initiativeparfa_id=3772. Inquiries: Dr. Yaffa Rubinstein - firstname.lastname@example.com
Multidisciplinary Fellowships in Cancer Nanotechnology Research
This is a renewal of RFA-CA-05-025 and will use the F32 and F33 award mechanisms. For more information, see http://cri.nci.nih.gov/4abst.cfm?initiativeparfa_id=3771. Inquiries: Dr. Jerry S. H. Lee - email@example.com; Dr. Piotr Grodzinski - email@example.com
Research on Malignancies in the Context of HIV/AIDS
This is a renewal of PA-07-173 and will use the R01 and R21 award mechanisms. For more information, see http://cri.nci.nih.gov/4abst.cfm?initiativeparfa_id=3770. Inquiries: Dr. Geraldina Dominguez - firstname.lastname@example.com
If Memory Serves...
In 1937, little was known about the origins of cancer. Some doubted that the cause of the disease would ever be understood and discouraged investment in this research. But scientists already understood that environmental exposures could cause tumors and that there may be a genetic component to certain types of cancer. (Read more)
For more information about the birth of NCI, go to http://www.cancer.gov/
On September 19, NIH Director Dr. Elias Zerhouni announced the recipients of the 2007 NIH Director's Pioneer Awards and the New Innovators Awards. This is the first group of New Innovator Awards and the fourth group of Pioneer Awards. Both programs are part of an NIH Roadmap for Medical Research initiative that tests new approaches to supporting research.
Pioneer Awards support scientists at any career stage, while New Innovator Awards are for new investigators who have not received an NIH regular research (R01) or similar grant. The 12 new Pioneer Award recipients will each receive $2.5 million in direct costs over 5 years. The 29 New Innovator Award recipients will each receive $1.5 million in direct costs over the same period.More information about these awards can be found at http://nihroadmap.nih.gov/.
Four New Members Appointed to DCLG
Marie Dahlstrom, of Portland, OR, represents De La Mano Frente Al Cancer: Latino Cancer Coalition. She is also a member of the Komen Breast Foundation National Hispanic/Latina Advisory Council and conducts research in cancer prevention, access to care, and domestic violence in the Latino community.
Everett Dodson, of Silver Spring, MD, represents Prostate NET. He is also a clinical research associate at the Howard University Cancer Center, where he serves as the director of prostate cancer screening.
Joyce Wilcox Graff, of Brookline, MA, is the Executive Director of the VHL Family Alliance, a nonprofit support organization that serves more than 15,000 patients and their family members dealing with von Hippel-Lindau (VHL) disease.
Arlene Wahwasuck, of Horton, KS, represents the Four Tribes Women's Wellness Coalition. She is a nurse and retired U.S. Public Health Service officer.
Teleconference Playback Available
The next teleconference will take place on October 31 from 1:00-2:00 p.m., ET. It will feature a discussion of the President's Cancer Panel report on cancer risk reduction. The call can be accessed toll free at 1-800-857-6584; the pass code is PCP. More information about the teleconference series is available at http://ola.cancer.gov/activities/teleconferences.
NCI Releases New Tool for Finding Cancer-Related Proteins
LabKey Software, in collaboration with the Fred Hutchinson Cancer Research Center, developed CPAS with funding from the NCI Clinical Proteomic Technologies Initiative for Cancer, which was launched in 2006 to help build the foundation of analytical systems, technologies, data, reagents, standards, and infrastructure to advance the understanding of protein biology in cancer and accelerate discovery research and clinical applications.
Researchers can obtain the CPAS software at https://cabig.nci.nih.gov/tools.
The Cancer Institute of New Jersey
Interim Director: Dr. Joseph R. Bertino • 195 Little Albany Street, New Brunswick, NJ 08903 • Phone: 732-235-2465 • Web site: http://www.cinj.org/
Research Activities
Patient Care Specialties
Other Notable Programs


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This page displays only a select list of music events.
Want to add Luther College Music Department events to your google calendar? Add this address: firstname.lastname@example.com and follow these instructions.
Sponsored by Music
Luther College Jazz Orchestra performs at the Homecoming Distinguided Services Award Night in the Center for Faith and Life.
Questions? Contact Kate Haller, 563-387-1737


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awesome!!!I finally formulated and posted a response to my SIL's comment on my Fb wall:
Considering this country was founded on prayer and that schools have "gone to hell in a hand basket" since they took prayer out of school, I'd have to disagree. Love ya anyway
My response was:
1) If anything this country was founded on freedom from religious persecution, so that individuals were and are free to practice the religion of their choice, or none at all. 2) Theres nothing preventing prayer from being in schools now. If you check the law, the only thing not allowed is TEACHER led prayer that is required of all students. Any student is free to pray on their own, or in groups, so long as it is not during class time. If you want the teacher led prayer brought back, be careful what you wish for. If theyre going to require ALL students to, for example, recite the Lords Prayer, that means they could also require ALL students to kneel East and pray to Mecca or require ALL students to sing from the Torah. 3) if you think schools have gone to hell in a hand basket, maybe its because class sizes are getting bigger while teaching staff is stagnant or decreasing, funding for existing and new programs is no longer there, and teaching is no longer respected as it once was not because teachers arent leading prayers during class time. And I love you anyways, too.
Thank you all!


text:
A Hamshire man has been indicted on one count of murder in the shooting death of the mother of his children.
The Jefferson County Grand Jury Thursday announced the one-count indictment charging James Martin Chaney, 44, of Hamshire, in the May 23 shooting death of Tina Gail Aubey, 42, of Hamshire.
Investigators say Chaney shot and killed Aubey at a home located in the 15600 block of Heckaman Loop in Hamshire.
The day of the shooting Deputy Rod Carroll told 12News a man who lives next to the house on Heckaman told investigators that Chaney walked to his house and asked if he could watch the kids because he had just shot the children's mother. He said Chaney then fled the scene with the kids.
A deputy constable from Jefferson County Precinct 4 Constable's Office saw a vehicle leaving the house. He followed it; giving out the direction of travel undetected by the driver. The vehicle stopped at the gas station at 24740 IH-10 (near Hamshire Rd). Deputies from the Constable's Office and Sheriff's Office approached the driver, later identified as Chaney, as he got out of the vehicle. Chaney was arrested without incident.
The two children were found inside the vehicle. A Sheriff's Office spokesperson said they were unharmed.
Newsroom: (409) 838-1212
Front Desk: (409) 833-7512
News Fax: (409) 981-1564
News Email: email@example.com


text:
Thinking about a career change? What about a career in beer? Beer Week kicks off this weekend, highlighting a growing industry in our state -- craft brewing.
Microbreweries are popping up all over Arizona and we got a look inside one of the biggest.
We went to Four Peaks in Tempe. Many of the people getting into this industry have turned a hobby into a legitimate career, and it seems consumers' thirst for local, unique beers keep growing.
Before the beer comes pouring out of the tap, it lives here and it is tended to by a team of schooled pros.
"It is a 6 hour day to make a batch a beer and then it sits in the fermenter for 2 weeks and people don't realize how long it ages," says Melissa Osborne, brewer with Four Peaks Brewery.
Osborne went to school for brewing beer, giving up a career in marketing.
"I don't have to be in a cubicle every day. I can come in here and chat with the guests and give tours and make great beers," says Osborne.
"It is so exciting for people sit here at our bar and say I love that beer can you make it again. That is why we do it really. To help please the customer."
And the customers keep coming back. In 2011, the Arizona craft brewing industry had an economic impact of more than quarter billion dollars. Ten breweries popped up statewide last year and at least ten more are expected this year.
"I am really pleased to see that it has. I have been at Four Peaks 8 years and I have just seen our growth and development and products and beers."
The beers are bottled on site too. So why the increase in breweries? Osborne thinks consumers' tastes are evolving.
"I think there is a lot of foodies or something too. They are actually developing more of a palate. The consumer doesn't want the same old Bud Light or something like that."
The craft brewing industry employs more than 1,500 people and that numbers is expected to grow.
In case this story got you a little thirsty, beer week begins on Saturday.
Online: arizonabeerweek.com
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Photo: myrecipes.com
BLT Sandwiches are great in a pinch. My favorite is the Italian BLT. I found this recipe in the October 2002 edition of Southern Living. I thought you might enjoy it, too.
Be sure to have on hand the following ingredients:
1/2 (16-ounce) Italian bread loaf
1/4 cup Italian dressing
1/3 cup shredded Parmesan cheese
1/2 cup mayonnaise
1/2 cup mustard
1/2 pound thinly sliced Genoa salami
1/2 pound thinly sliced mortadella or bologna
4 (1-ounce) provolone cheese slices
Romaine lettuce leaves
3 plum tomatoes, sliced
8 bacon slices, cooked and cut in half
Garnish: pimiento-stuffed green olives
Preheat your oven to 375°
To prepare your Italian BLT Sandwiches, cut the bread diagonally into 8 slices; arrange them a baking sheet. Brush the slices evenly with Italian dressing, and sprinkle with Parmesan cheese.
Bake for 5 to 6 minutes until lightly toasted.
Stir together mayonnaise and mustard; spread the untoasted side of the bread evenly with mayonnaise mixture.
Layer 4 bread slices, mayonnaise mixture side up, with salami and the next 5 ingredients. Top with the remaining 4 bread slices, mayonnaise side down. Secure with wooden picks. Garnish if you desire.
There are more food & drink receipes @ http://929wlmi.com/latest-updates/authors/34/


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Insurance 3 - Ministry Videos
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We've never seen anything like this before!
Roger Triantafilo from Bakersfield, CA posted a video on YouTube of their family cat coming to the rescue.
The video shows his son riding his bike in front of the familys home when a stray dog started attacking the boy.
Within seconds, the familys cat jumped on the dog to get it off the boy. The cat then chased off the dog.
Thankfully the boy is fine after receiving some serious injuries you see at the very end of the footage.
~BS and Vanessa


text:
The Tyler City Council is closer to bringing a new conference center hotel to Tyler.
Back in June, KLTV told you about the proposed project that developers said would attract thousands of conferences a year, money Tyler has missed out on in the past.
Copyright 2013 KLTV. All rights reserved.
A pet goldfish is off-the-hook and alive after a micro-surgery removes a tumor from his brain.
105 West Ferguson Street
Tyler, TX 75702
FCC Public File
EEO Report
Closed Captioning


text:
It was all caught on camera as three men set their sights on a brand new 2013 Buick Regal on Rossini on Detroit's east side."The camera alarms triggered that somebody was entering the driveway," said Joe Bragg.That alert showed up on his cell phone."The person that's in the house, she was actually in there dialing 911 at the same time and had them on the phone while the guys were actually doing everything," Bragg said."She hollered at them. The first guy looked up and ran, and then the second guy told him no, come back.""They end up breaking the water spout on the side of the house, and once they broke that out, they had real guts and went and got their van, pushed the car off the house, backed it back out the driveway and then turned the car at an angle that they couldn't get to, so they drove on the neighbor's grass to back the car up, pushed it backwards," Bragg further explained.
"Then he went across the street on other neighbor's grass, turned his van around, came back behind her car and just jammed it and just pushed the car all the way around the block."
Watch Andrea Isom's video report to see the surveillance footage.The car was found stripped 30 minutes after police showed up.
205 N. Michigan AvenueGround FloorChicago, IL 60601Station Operator: (312) 565-5532Newsroom: (312)565-5533


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|# Of Rooms
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Hotel Plaza Florencia is located in Mexico Citys Zona Rosa (Pink Zone), half a block from The Angel de la Independencia, is surrounded by entertainment ...
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Baja Expeditions is the world's leader in eco-adventures in Baja California, Mexico. Swim, kayak or scuba dive on live-aboard boats in the Sea of Cortez. Or, go whale watching in San Ignacio Lagoon and Magdalena Bay on the Pacific side....
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Qi Gong Spiritual Retreat in Puerto Vallarta, MX
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Study Spanish in the heart of the historic Unesco world heritage city of Querétaro, Mexico. Our small Spanish school focuses on giving personalized attention to Spanish students from all over the world. QLS is an Official DELE examination centre!...
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Central America Explorer with MARVELUS TRAVEL
Mexico City, Mexico Sight-Seeing Tours
We are an expert service destination management organization, based in Mexico & Central America, specializing in the design, promotion and operation of adventures and independent travel services....
Starting at $1,200 Per Person
|Link Code


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Like us on Facebook for inter-esting movie poster-related stuff:
Superman posterCopyright by respective production studio and/or distributor. Intended for editorial use only.
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Cast: Marlon Brando, Gene Hackman, Glenn Ford, Margot Kidder, Ned Beatty, Jeff East, Marc McClure, Valerie Perrine
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text:
By Kelsea Stahler, Hollywood.com Staff
Let's start by clarifying one important fact: I love South Park. Its crass, disgusting humor is a thing of beauty, wrapped in the careful, intelligent, and dare I say thoughtful comedy that serves as a framework for the whole affair. Creators Trey Parker and Matt Stone are smart guys. And in most cases, it shows in almost every episode of the 15-year-old show. But, as their musical, The Book of Mormon, gained traction and the duo became busier, fans have complained that the quality of their claim to fame has suffered. And in some cases (sorry, ""Human Cen-iPad"") they have misstepped, but for the most part, they're still delivering the same level of absurd commentary we've come to expect. Unless of course, they're taking a stab at reality television stars.
The latest starlet to get the South Park treatment is pint-sized pageant queen Honey Boo Boo Child, and unfortunately, Parker and Stone's cartoon darling didn't quite live up to its reputation. The episode included Honey Boo Boo and her mother, as seen on Toddlers & Tiaras and Here Comes Honey Boo Boo, as the inspiration for Cartman accepting his own obesity and eventually landing his own show as Fatty Doo Doo. Now, this seems like a perfectly good set up to launch into a thoughtful parody helped along by the series' signature bathroom humor aimed at television networks, like Honey Boo Boo's TLC and the Real Housewives hub, Bravo. It seemed like the perfect opportunity to skewer them for promoting unhealthy behavior, and we almost got there.
Token, the boys' friend from school, sets up Cartman's show, but that storyline is quickly hijacked by James Cameron, Michelle Obama, and Honey Boo Boo's pig heart transplant. As a result of Cartman's new show and Honey Boo Boo's fame, Cameron goes on a misguided mission to move The Bar (a big taste-making device somewhere in the ocean), signaling that we, as a society, have decided we don't want anything above pig slop on our televisions. We witness Honey Boo Boo get a pig's heart (and act like a little oinker as a result) and as a way of mocking her mother's "Sketti" recipe (ketchup, butter, and the integral "sketti" noodles, of course), the episode ends with a wrestling match in the high calorie stuff.
The result is little more than Cartman seated in a Rascal scooter while running over the small, pageant-loving child. Finally, it all comes to a close when Michelle Obama pummels Cartman as a way of taking out childhood obesity. And we're all left to sit and wonder why we switched over from the admittedly boring Presidential debates to watch this regurgitation of every Honey Boo Boo joke we've ever heard.
But it's not an isolated incident. Take for example, "It's a Jersey Thing," which took aim at The Real Housewives of New Jersey and (probably more pointedly) Snooki and her Jersey Shore cohorts. The town of South Park is threatened by a scourge of Jerseyites who excuse all bad behavior with the phrase "It's a Jersey thing." Finally, the invasion becomes so horrible - marked by the growling cries for "smush, smush" by the Snooki troll - that the town calls in Al Qaeda to take out the Jerseyites. That's right. Al Qaeda is preferable to fist-pumping, table-throwing, outrageous people from Jersey. It was a knee-jerk response, and nothing better than a conglomerate of all the chatter already surrounding reality TV's Jersey obsession.
The same thing happened when they tackled reality star and pop culture phenom Paris Hilton, whose South Park character was an idiot whose clothing line was called "Stupid Spoiled Whore" and included the tagline "Remember to party and be super lame to everyone" and touted a kit for making sex tapes. Sure, it was funny because we all needed a rest from Hilton's fame monster, but was it clever? Not really. Later, the series didn't even do anything special with Caesar Milan of The Dog Whisperer, who was brought in to train Cartman to behave. We were treated to an episode of Cartman voicing the things that we assume every dog on that show is probably thinking. Not quite as brilliant as most of South Park's other fare.
So, why bring up this issue now? Why not criticize the series for its portrayal of Snooki as a sniveling little monster who'll hump anything? Why not get mad at the lazy joke on Paris Hilton? Well, this time around, the target is a little girl. And while the series could have taken aim at the industry, it took down a child who's simply having fun doing what she was raised to do. And it took her down harshly.
But it's not just that the joke was mean. South Park is always ruthless and always mean to everyone, even if it might offend an entire religious population. (And, heck, the series has been killing children specifically Kenny since its inception.) While everyone else is joining in on the Honey Boo Boo bashing, of course South Park is going to get into the fray. But after witnessing what South Park can do with every political topic under the sun, movies, celebrity relationships, Scientology, and its cartoon series competitors, it's no wonder we'd expect some innovative take on the TLC phenomenon.
These are the folks who took Queer Eye for the Straight Guy and turned it into a front for an alien race of crab people who were trying to take over the world. The people who gave us an episode about the entire planet being one giant reality show run by an alien who could become anyone, even a taco that poops ice cream. These are the creative people we look to when something mockable makes its way into the pop culture realm. We expect excellence and taco-flavored kisses, not two overweight kids fighting in a glorified slop bucket.
Did you enjoy the Honey Boo Boo episode?
Follow Kelsea on Twitter @KelseaStahler
[Photo Credit: TLC]
Honey Boo Boo Ratings Beat Republican National Convention
'Here Comes Honey Boo Boo' For a Second Season: The Internet Implodes
What Happens When Reality Bites Back at Honey Boo Boo?


text:
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text:
The MTA said repairing the damage caused by Hurricane Sandy to its transit systems will cost $5 billion. And preparing for the next superstorm could cost another $4 billion.
The money will come from the federal government and insurance, not fare hikes other than the March 1 increase, the MTA said.
At a City Council hearing on Tuesday about the MTA's Sandy response, New York City Transit President Tom Prendergast said his agency needs to be ready for more monster storms.
MTA officials said the authority has learned from each monster storm to hit the city in the last three years.
The December 2010 blizzard was a debacle where buses were sent out in deep snow without chains, got stuck, and blocked streets. The predicted flooding of Irene in 2011 prompted the MTA to shut down for the first time. That lesson was applied during Sandy last year.
The council members then gently inquired about future plans like coverings for subway station ventilation grids and giant rubber bubbles to cover the entrances of tunnels.
The chair of Community Board 1 said the Lower Manhattan economy needs the South Ferry station returned as soon as possible and even better preparation for the next super storm. The MTA said that in two to three months it will announce a timetable for when the station will be repaired. The MTA expects that timetable will be in less than the original two- to three-year estimate.
During the hearing, environmentalists and businessmen called for, respectively, more bicycle and ferry use.


text:
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text:
The decision to cast an 18 year old high school girl to appear in a collection of sexually-suggestive photographs has caused a dispute on the Internet over the suitability of using a teenager in these images.
Applemilk Communications (www.hellokind.co.kr), a publisher well-known for collections of photos of amateur models, announced Monday that it has selected Choi Eun-jung, a high school junior, as one of two models who will be featured in the third edition of its ``Kind Glamour'' photo series.
I checked and Naver lists her date of birth as 1991; often in Korean papers the age listed will be two years higher---18 in Choi's case---because of the Asian age-reckoning system. The HelloKind page doesn't seem to be working now and instead just has these two pictures (Choi is on the right).
Googling around shows its specialty is busty women in bikinis and lingerie, and I wonder if it's any coincidence that "Kind"---in addition to being an English adjective" also means child in German. The article continues:
``The domestic photo collection market has been growing fast but the quality of models has been sliding, failing to meet public expectations,'' said Shim Young-gyu, president of Applemilk Communications. ``We focused on young models this time.''
It is the first time in three years that a high school girl has been picked as a model for the collection of photos in which models pose in revealing attire. In 2006, Lee Ji-yeon modeled for a collection of sexually-suggestive photos at the age of then 17.
The selection of Choi is drawing criticism from some netizens on Web sites. ``It's not right to pick a teenager for these types of pictures,'' said a netizen with the username ``muse.''
However, Shim said current laws do not ban high school girls from appearing in these shoots.
Well, in spite of the headline "Selection of Highschooler for Glamour Model Causes Stir," it looks like the Korea Times is merely advertising for the site. After all, the "stir" comes from one lone netizen, expressing a fairly generic opinion.
James Turnbull of The Grand Narrative last night on Twitter reminded me of the story from January of semi-nude photographs of a 14-year-old model and the controversy it caused in Korea. As a language aside, "glamour" (글래머) in Korean means busty, but has a different meaning in English.
And on Chosun.com last week, pictures of Chinese high school girls in bikinis.


text:
MONROE — The Glenbrook Apaches broke a scoreless tie with a six-run third inning and went on to beat the River Oaks Mustangs, 11-2, Tuesday night in Game 1 of the MAIS North State Finals in Monroe.
"I thought we played pretty well," Glenbrook head coach Jonathan Hardy said. "We didn't walk anybody, didn't make any errors and we had 15 hits, which is one of our highest hit totals of the year."


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text:
Charming Hearts Quilt
Hi all! : ) This is Jera from http://www.quiltingintherain.com/ and I'm excited to be posting my 2nd MBS tutorial! I just LOVE the simplicity of this quilt.
The main heart blocks are made up of 4 charm squares. Easy peasy! For the other blocks, I cut out hearts from leftover charm squares and appliquéd them onto a solid white layer cake. To appliqué, I simply used fusible interfacing (e.g. steam-a-seam) and then stitched a ¼ inch seam around the perimeter of the heart. After a few washes, a cute little fringe will develop around the heart. It's my favorite and fastest way to appliqué. Check out my 7-step tutorial below. =)
2 charm packs, Bliss
1 layer cake, Bliss
1 layer cake, solid white
½ yard inner border
4 yards backing
(Note for newbie's: when I refer to "sewing," always sew with right sides of fabric facing together, align the corners, pin the fabric so it stays in place, sew a ¼" seam, and then press open.)
Step 1 – Prep fabrics for the main heart blocks
Sort the charm squares by color and create 20 piles with 3 matching charm squares in each pile. Next, take 5 white layer cakes and cut (4) 5" squares from each. This will give you 20 white 5" squares. Distribute one white 5" square to each of the 20 piles you previously sorted.
Step 2 – Sew the main heart blocks
To make one main heart block, take one pile of charm squares (sorted from Step 1), and arrange them like the following picture. As shown below, sew the squares together to create 2 units.
Then, sew both units together to create one block. Repeat until you have all 20 blocks sewn.
Step 3 – Prep the white background for the appliqué blocks
Take 12 white layer cakes. Trim each one so they measure 9.5"x9.5". Layer the fabric for faster cutting.
Step 4 –Follow steps A-G below to appliqué the hearts using steam-a-seam. Use leftover charm squares for the hearts. Repeat until you have a total of 12 appliquéd blocks.
A. From a 5"x5" piece of scrap paper, draw and cutout a heart as shown below. You will use this paper heart as a stencil for all the fabric hearts.
B. Next, cut out steam-a-seam to ~ 4.5" squares. As shown below, iron the steam-a-seam to the wrong side of a charm square.
C. Use a marker to trace the paper heart (cut from step A) on the wrong side of the charm square (onto the steam-a-seam layer).
D. Using fabric scissors, cut out the heart.
E. Peel off the steam-a-seam layer from the fabric heart.
F. Place the heart on the white 9.5" square (from step 3) and press in place.
You can arrange the hearts any way you like. Below is another fun idea…
G. Stitch a ¼" seam around the perimeter of the heart.
Step 5 – From your white layer cakes, cut the following (for faster cutting, stack your fabrics):
- Take 7 layer cakes and trim each one to measure a 9 7/8" square. As shown below, cut each 9 7/8" square in half diagonally to form 2 half square triangles. These will be the sides of your main quilt top.
-Take 2 layer cake squares and trim each one to measure a 7 5/8" square. As shown below, cut each 7 5/8" square in half diagonally to form 2 half square triangles each. These will be the corners of your main quilt top.
Step 6 – Arrange all your main blocks and half square triangles cut from the previous step as shown below. Sew the blocks/half square triangles together in diagonal rows, as designated in red. Start by sewing all the blocks/half square triangles in each row together, and then sew all the rows together.
Step 7 – Sew the inner borders and outer borders to the main quilt top:
-Inner border: From the ½ yard of fabric, cut (7) 2.5" strips. These will be for your inner border. First sew the left and right inner borders to the main quilt top. Trim excess fabric.
-Outer borders: From your non-white layer cakes, choose 14 squares. Sew 2 rows of 7 squares together. Cut each row in half lengthwise to form 2 border strips, as shown below.
Start by sewing the left and right inner borders onto the main quilt top, and then the left and right outer borders. Trim excess fabric so the borders are flush with the quilt top and bottom. Repeat, but for the top and bottom inner and outer borders.
Quilt and bind! Click HERE for easy, Quick Quilt Binding.
77" x 62" quilt
20 comments:
- Carrie said...
this is beautiful!
- August 16, 2010 at 7:22 AM
- Sherry said...
Love it. Charming, indeed!
- August 16, 2010 at 7:36 AM
- eatmoresmores said...
This is so pretty! I hope to make one like it.
- August 16, 2010 at 7:54 AM
- Karen said...
What a sweet quilt! Love it! It's going on my to-do list. Thanks!
- August 16, 2010 at 10:08 AM
- Peggy said...
I wish this had been out a few months ago when I was making my grand-daughters quilt. It is really cute. Oh well, maybe next time.
- August 16, 2010 at 6:55 PM
- Jackie said...
I am shocked by the simplicity of the quilt - yet it's beautiful outcome! This is the perfect pattern for young and old alike.
- August 16, 2010 at 8:26 PM
- lidia said...
I just LOVE this whimsy quilt, everything from the fabrics to the pattern. Perfection! The step by step instructions along with photos make a novice like me believe I could make one. Keep the tutorials coming. Feeling inspired!
- August 16, 2010 at 9:17 PM
- Joy said...
the colours are always so beautiful wish I had such a good eye for colour
- August 17, 2010 at 1:42 AM
- Joy said...
the colours are always so beautiful wish I had such a good eye for colour
- August 17, 2010 at 1:43 AM
- Karyli said...
How very sweet! I love your blog too.
- August 17, 2010 at 3:14 PM
- Clara said...
I think this is a really sweet quilt!
- August 17, 2010 at 5:11 PM
- Lisa A said...
So pretty and so easy! I might have to make this one.
- August 17, 2010 at 5:52 PM
- NaomiG said...
This quilt is precious! I love it, and I love the fabric choices!
- August 20, 2010 at 10:30 AM
- Jen T said...
This quilt is so cute! I have a ton of pink and red scraps and now I've found the perfect pattern.
- September 10, 2010 at 10:56 PM
- Diane H said...
-Take 2 layer cake squares and trim each one to measure a 7 5/8" square. As shown below, cut each 5 5/8" square in half diagonally to form 2 half square triangles each. These will be the corners of your main quilt top.
The above step appears to be an error - can you please clarify?
Thank you.
- November 21, 2010 at 11:31 AM
- Quilting In The Rain said...
Hi Diane - thanks so much for bringing this to my attention! It should read 7 5/8", NOT 5 5/8. I corrected this on the tutorial so everything should read correctly now. Thanks again! -jera
- November 22, 2010 at 2:59 PM
- Janine said...
Can you tell me how much fabric is needed for the binding? Or is it calculated into the backing? Thanks.
- August 24, 2011 at 2:13 PM
- Quilting In The Rain said...
Hi Janine - there's enough backing to do the quick quilt binding (where you fold the backing fabric over and onto the quilt top to create the binding). Howevever, if you choose to do your own binding, you'll need 1/2 yard. Hope this helps! Thanks for checking out my tutorial :)
Happy Quilting!
- August 25, 2011 at 4:16 PM
- Richard Healey said...
I am working on a heart quilt similar to this. My wife loves hearts will have to send her here to get more ideas.
- January 9, 2012 at 4:00 PM
- Angela9772 said...
The steam a seam that you use, how does that stand up to washing?
- January 28, 2014 at 10:40 AM


text:
I will give you 1,000 acres of land on Planet Orgy for your people if you aid us in this military conflict.
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Zahru II wrote:I presume she was banned and not banned at the same time; it was Schröedinger's ban.
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Tzan wrote:Semaj Nagirrac wrote:Well, I took some land without checking if it was owned by a faction or not. I'm not going to be banned, am I? I can destroy everything if need be.
That's what Hitler said,
in 1938.
The Shadowscythe wrote:I would try to be annoying right now, but I can pull that shit off anyway it seems.
1 day doesn't equal four Mrs goderator.
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ROLAND in UT
First of all, Rocky Mountain KNOWS how to pack an expensive seat. Thank You for taking pride in the packaging. This seat is very comfortable and works far better than any original seat I've used. It only feels expensive until you ride with it, then the cost becomes quite reasonable. I woudl give this seat 6-7 stars if the rating system allowed it. Really, its that good.Read All Reviews


text:
LOS ANGELES (AP) - He already has a Super Bowl ring, and now football star Donald Driver can add the "Dancing With the Stars" mirrorball trophy to his awards collection.
The Green Bay Packers receiver won the ABC dance show Tuesday after wowing audiences and judges with his kickin' country-themed freestyle routine. He and partner Peta Murgatroyd hoisted the glittery prize above their heads after being named the new "Dancing" champs.
Streamers and confetti rained down from the ceiling, filling the ballroom as they celebrated. Driver's wife and children joined him on the dance floor.
With just one point separating the three finalists, it was up to the viewers to pick the winner.
He and his fellow finalists, Welsh singer Katherine Jenkins and Cuban actor William Levy, each earned perfect scores for their last performances Tuesday. Jenkins came into the final contest with a perfect 60 points; Driver and Levy each had 59.
Judges' scores combined with viewer votes determined the result.
Contestants eliminated throughout the show's 10-week season reunited for the two-hour finale. Martina Navratilova, Gavin DeGraw, Jack Wagner, Jaleel White, Sherri Shepherd, Melissa Gilbert, Roshon Fegan, Maria Menounos and Gladys Knight all donned costumes Tuesday for one last dance.
Knight did double performance duty, also singing "The Way We Were." Kelly Clarkson also performed on the show.
The next round of "Dancing With the Stars" will feature contestants from past seasons.
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Mention the romantic city of Venice, and immediately, scenes of Romeo and Juliet come to mind, as well as canals and gondolas. Whilst there is certainly an aspect of this in the Italian city, there is also so much more besides. By staying in an apartment in Venice city centre, you will be right in the heart of things, and be easily able to explore this fascinating and unique place. All self catering accommodation in Castello, Venice, is of a wonderful standard, meaning that you will have all the creature comforts of home whilst you are on vacation.
Holidays in Castello, Venice, have so much to offer that it is almost hard to know where you should begin. Probably the area that is most visited, is the San Marco piazza. This area, dedicated to San Marco, or Saint Mark in English is surrounded by amazing buildings such as the San Marco basilica, and amazing clock tower and much more besides. Leading off from the piazza, or square, are many streets which have enough shops to keep even the most frenzied of shoppers in a state of ecstasy! A trip to Venice is not complete without a gondola ride on one of the canals of course, and many a tourist has been tempted to sing "Just one Cornetto" whilst doing so!
Being a city centred on a series of islands and connected by canals, water transport is all important here. Nowadays, there is a very good water bus service that can provide an easy way to get around, and enables you to see the city in greater detail. You will be able to take a trip out to specialist glass making areas (e.g. Murano), as well as visit the many museums which will add to your knowledge of this fascinating place. Catching a concert in Venice is highly recommended, and there are normally various performances going on, from the amateur to the professional recitals of composers such as Vivaldi. Although your self catering accommodation in Castello will have everything that you need in order to cater for yourself, a visit to one of the quality restaurants will be an experience in itself.
Holidays in Castello can be taken at any time of year, but some months are undoubtedly better than others. From spring to early summer is probably the most pleasant time of year to visit, with the humidity and heat of July and August not being present. The autumn can be a time of seasonal thunderstorms, which can cause some of the canals to rise quite dramatically in height. Winter time can see the temperatures drop almost to zero at times, but in a way, adds to the romance, especially on a gondola!
Travellers on their holidays in Castello, Venice, will more likely than not arrive by air. The Marco Polo airport (VCE) is located just 12 km outside of the city, and most of the major airlines fly into here from cities around the world. Alitalia, British Airways, Jet2, easyJet and Ryan Air fly into Venice from airports such as London Gatwick (LGW), East Midlands (EMA), Bristol (BRS), Birmingham (BHX) and Newcastle(NCL).


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By CHARLES ODUMAP Sports Writer
FLOWERY BRANCH, Ga. (AP) - The bottom line doesn't look good for the Falcons' red-zone production.
After failing to score touchdowns in five of six possessions inside New England's 20 last week in a 30-23 loss, the Falcons rank near the bottom of the league in red-zone production.
Offensive coordinator Dirk Koetter says the numbers are "frustrating and encouraging at the same time."
Koetter said Wednesday the good news is the offense is providing so many opportunities inside the 20. But he says the Falcons must do a better job of taking advantage of those scoring chances in Monday night's game against the New York Jets.
The red-zone woes have helped drop the Falcons to 1-3 for the first time since 2007.
Copyright 2013 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
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August 30, 2012
We offer e-newsletters that deliver targeted news and information for the entire fleet industry.
The expert, Mark Betner from Citgo will answer your questions Ask a question
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TMW Products Adds Integration with ALK Software
Rand McNally Products now Integrate with TMT Fleet Maintenance Software
New Book Details History of Fruehauf Trailers
Thermo King TracKing Integrated with McLeod's LoadMaster Symphony


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Letters to the Editor - Dec. 28, 2012
Dec 28, 2012 | 14 Comments
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":The importance of this article will scarcely be doubted by any persons, who have duly reflected upon the subject. The militia is the natural defence of a free country against sudden foreign invasions, domestic insurrections, and domestic upsurpations of power by rulers. It is against sound policy for a free people to keep up large military establishments and standing armies in time of peace, both from the enormous expenses, with which they are attended, and the facile means, which they afford to ambitious and unprincipled rulers, to subvert the government, or trample upon the rights of the people. The right of the citizens to keep and bear arms has justly been considered as the palladium of the liberties of a republic; since it offers a strong moral check against the usurpation and arbitrary power of rulers; and will generally, even if these are successful in the first instance, enable the people to resist and triumph over them."
--Joseph Story
Supreme Court Justice
And the much ballyhooed 'Arab Spring' ... does come to mind..
Excluding yourself, and the children of course, just about how many does the term 'everyone' constitute? 5, 10, 15, 20 people?
Heck, David, our very own government hands out free for the taking...fully automatic high capacity weaponry to GROUPS OF POORLY TRAINED CIVILIANS in other countrys so that they may defend themselves.
Take the country of Switzerland for instance, did you know that most (if not all) adult male citizens keep a fully automatic weapon stored in their homes for emergency use. I dunno, maybe it's because they spend more time yodeling than they do watching Bruce Willis and his Die Hard films ... why do you think that is?
On the other hand, it seems that those who have the position to use the bully pulpit to oppose ideas (such as armed guards in schools) don't even attempt to walk the walk -- President Obama's daughters attend a school that employs 11 armed guards (similar to the children of many other high ranking government officials).
Under those circumstances, it's rather obvious our elected leaders use a different set of values when proposing (or opposing) legislation for the general population when compared to their personal choices. It appears that the more important the position, the less chance of a conscience getting in the way.
Gotta wonder which of those two guys prefers to own his very own Bushmaster semi-auto over the government issued and maintained version?
Why do you think that is, David? My only question would be...does our ex-president prefer to have 30 round magazines ..or.. the standard issued 20 round version when it boils down to defending their own hearth's & home's?
Now...if you will, try to imagine just how inconvenient it would have been for a deputy requesting the same help in a more rural area.. Any thoughts?
Not having 'a spectacular difference' would include nearly half of Congress, who send their kids to protected private schools, as does NYC Mayor Bloomberg. In fact, 39% of Chicago public school teachers opt for private education for their children. One shouldn't believe that is a simple coincidence.
The message can polished and shined until the glossy finish is gone, but it stills comes down to being truthful on all accounts.
I just read an interesting article about the Norovirus that concerns me, and should concern everyone. The virus is highly contagious and kills 800 Americans a year, yet, nobody is calling for those having been diagnosed with the illness to be involuntarily committed ..or.. taken off the streets for the safety of their surrounding community.
From my perspective, allowing diagnosed carriers of the Norovirus to walk freely about the communty is no different than allowing loaded firearms in the hands of children. Yet, you don't notice anybody advocating for suspension of any Norovirus carrier's Constitutional rights.
Why do you think that is?
Because the government needs and wants (and availability to them) do not necessarily coincide with those of the general public. Besides, didn't you know that people don't kill people, Norovirus does!
Obviously, that's not going to happen.
• Amity man reported missing (7364)
• Pro and Con on Measure 88 — Alternative driver's license for undocumented immigrants (2652)
• County's economic development efforts questioned (2584)
• Highway 99W through Dundee has reopened (2055)
• Leaping ability (2053)
• Heavy rain on the way as fall's arrival brings first storm (1941)
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• Amity runs past Sheridan (1751)
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• Pain summit to address opioid abuse (6)
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• Not guilty plea in Oregon work-release homicide (3)
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Police in Sterling Heights say a woman suffered minor injuries after she was struck with bullets that hit the vehicle she was driving. The woman's husband says the shooting happened while she was out shopping. The gunshots are said to have struck the woman twice. Police say they are having trouble determining exactly what happened because the couple is Serbian and speaks little English. What they have established is the woman's vehicle has six bullet holes, she was struck twice and hospitalized with minor injuries. Police believe she may have left work in the area of Mound and Hall roads around 3 p.m. Monday and then stopped at several stores before returning home around 9 p.m.Lt. Kevin Reese tells Fox 2's Amy Lange, "We feel that this is an isolated incident." He maintains Sterling Heights is one of the safest communities in southeast Michigan. VIDEO: Click on the video player above to hear more from police and neighbors in Lange's reportIf anyone has information contact Sterling Heights Police Department at (586) 446-2800.
205 N. Michigan AvenueGround FloorChicago, IL 60601Station Operator: (312) 565-5532Newsroom: (312)565-5533


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What Does A Severe Storm Watch Or Warning Mean?
Date Jul 02
Often times, we may see the phrase "Severe Storm Watch" or "Severe Storm Warning" flash across the news screen. Although these two sayings have similarities, they do not mean the same thing. Severe Storm Watch A severe storm watch means that there is a strong potential for a severe storm to develop. Strong winds and [...]
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I might be alone on this one, because I haven't heard anyone talking about it today, but I think this was my favorite commercial of the evening.
Or at least, the commercial that I gave the biggest unexpected laugh to, if that makes sense.
But keep in mind I had already watched the Doritos commercials, the Full House yogurt commercial and a few others before last night...
That was the part that got me.
And at the gathering I was at, it seemed like that moment completely went by unnoticed by everyone else.
Not me, though. "LOOK, IT'S RUDY! AND HE'S SLOW CLAPPING! RUDY! RUDY!"
And after searching for the commercial on The YouTube, I was delighted to see they've created an all puppy version!
YouTube Description: If the Big Game has a puppy version, why don't the Big Game's commercials have puppy versions? Well, now one does. #slowclap #slowbark


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Q&A with Regina Belle at the 2008 GMA'S - Today's Christian Videos
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This compact turbo whisk can handle everything from morning lattes to pancake or waffle batter. Pick your job, pick your attachment—innovative engineering provides customized mixing speeds. For whipping meringues and mousses or heavy batters, select the whisk attachment. For making omelets or frothing milk, opt for the frother attachment. Stainless steel attachments are dishwasher safe. Uses 6 AA batteries, not included. (1¾"W x 7"L x 4"D)
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Ahmedabad - Sarovar Portico - 1 Night Stay Offer
- 1 N / 2 D for INR 4599 (Single / Double Occupancy)
- Business Package
- 15% discount on food and soft beverage
- Breakfast, wifi, one way airport or railway station transfer, 2 pcs laundry, Fruit and cookies platter, Taxes.
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- Breakfast, that is part of the package, is a buffet / fixed menu. Breakfast ordered in the room will be charged extra.
- For airport / railway station pickup where applicable, arrival details are required at the time of booking.
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hotel special offer:
12-Sarovar Portico, Ahmedabad


text:
Hungry for something pot-roasty, I went looking for a recipe that would inspire me to do something outside of my usual ouvre of Provencal French cooking. Of course, I found something instantly attractive to me because it was perfectly within my usual ouvre but nonetheless slightly different than what I would have reflexively done (figs!), so it qualifies. It's on the menu for tomorrow: thought I'd share the recipe. I'll report back.
Braised Pork Loin Roast With Rosemary and Figs
2 cups dry white wine
1 8-ounce package dried Calimyrna figs, stemmed, halved lengthwise
1 tablespoon olive oil
1 6-rib blade-end or center-cut pork loin roast, chine bone removed, ribs cracked
1 medium onion, chopped
1 medium carrot, peeled, chopped
1 tablespoon chopped fresh rosemary
2 garlic cloves, chopped
1 14-ounce can low-salt chicken broth
1 tablespoon butter, room temperature
1 tablespoon all purpose flour
2 tablespoons Dijon mustard
PreparationPreheat oven to 300°F. Bring wine and figs to boil in small saucepan. Remove from heat and let stand until figs soften, about 15 minutes. Drain figs, reserving wine and figs separately.
Meanwhile, heat oil in heavy large ovenproof pot over medium-high heat. Sprinkle pork with salt and pepper. Add pork to pot and cook until browned on all sides, about 8 minutes total. Transfer pork to platter.
Add onion and carrot to same pot. Cover and reduce heat to medium-low. Cook until onion is golden brown, stirring occasionally, about 8 minutes. Stir in rosemary and garlic; sauté 1 minute. Add broth and reserved wine.
Return pork to pot, meat side down. Bring to boil. Cover and transfer to oven. Bake until thermometer inserted into center of roast registers 150°F, adding figs during last 10 minutes of roasting, about 1 1/2 hours.
Transfer pork to cutting board. Using slotted spoon, transfer figs to small bowl. Tent pork and figs with foil to keep warm. Spoon fat from surface of sauce. Bring sauce to boil. Stir butter and flour in medium bowl to blend. Whisk 1 cup sauce and mustard into butter mixture. Whisk mustard-butter mixture into sauce in pot. Boil sauce until thickened and slightly reduced, about 8 minutes. Season to taste with salt and pepper.
Transfer pork to platter, surround with figs, and pour sauce over. Carve pork between rib bones.