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Mobile Users CLICK HERE To See Slideshow Photos
UPDATE: On Monday we learned more about the couple who passed away in the crash that happened near Big R, a store where the two were regular customers. Friends say Floyd and Margaret Nordhagen were on their way to buy cat food at the store before the accident.
92-year-old Floyd Nordhagen and his 88-year-old wife Margaret have been part of the Elk Community for decades. They were members of the Elk Community Church and cared for several animals. Their son, Marv Nordhagen, says they have cats, dogs, and cattle he is now trying to find a place for.
According to people in the area, the two were always together and often came to Big R, near where the crash happened.
Floyd is described as someone everyone like, a man who would help anyone in need, and a husband who always took great care of his wife, who suffered from Alzheimer's.
A family friend says one day Floyd stopped him and said, make sure you always hug and kiss your wife, that is something I do everyday.
According to Washington State Patrol, Floyd and Margaret were found holding hands in the car after the accident. Their son says he thinks his mom probably grabbed Floyd's hand when the accident happened. Both died at the scene of the crash.
Although it is a very sad situation, many say it is a blessing the two were taken together.
A memorial service has not yet been scheduled.
KHQ.COM - We now know the names of two people killed in a crash Sunday afternoon on Hwy. 2 about 4 miles north of Spokane. They've been identified as 92-year old Floyd Nordhagen and 88-year-old Kathryn Nordhagen of Chattaroy, Washington.
The two were driving out of a store's parking lot when they crashed into a pickup truck that was turning into the parking lot. Both Floyd and Kathryn were trapped inside their car and they died at the scene.
The people in the pickup truck, Kenneth Voss and Pamela Ross, were not injured. A dog was thrown out of the vehicle because of the impact, but he was found and is okay. No charges have been filed.
KHQ.COM - On Sunday two people died in a car crash on U.S. Highway 2 about four miles north of Spokane, the Washington State Patrol said.
It happened about 4:30 p.m. So far we don't not know the identities of the victims. We'll post more details as we get them. Keep checking back to this web channel for updates.


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The marquise gem cut was created at the request of the Sun King, Louis XIV, to evoke the smile of his mistress, the Marquise de Montespan. The sleek tapered shape of this Gemvara Essentials ring echoes the gem perfectly and will make you smile every time you see it. See Details
Gemvara jewelry is truly personal: you design it, choosing gems and metals to celebrate your story, and we craft it just for you. We'd love to help you find your perfect piece! (more)What quality are your gemstones?
They are all-natural and hand selected fine quality. (more)

subset: commoncrawl


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(Palermo, Agrigento, Syracuse)
In every corner of these enchanting islands is an opportunity for transcendent encounters.
Immerse yourself in the mystery and intensity of these two incredibly diverse islands. Explore Sicily's exquisite architecture and artistic monuments, still standing after thousands of years. Experience Greek ruins in lush valleys that are blanketed in oleander and juniper blossoms. Discover megaliths, medieval towers and baroque churches on mythical Malta, which has been referred to as an "open-air" museum. Drive up and down jagged coastlines and stop to stroll through fresh fish markets along the way. At night, relax in charming and distinctive accommodations that suggest a bygone era.
With your guide, wander the wide boulevards of Palermo's Old Quarter and visit the astonishing baroque palaces, 12th century Cathedral and dizzying food market replete with epicurean delights. In Segesta, tour the Doric Temple, one of the best preserved Greek temples in all of Europe. Visit Syracuse and head to the ancient temple of Apollo which was built in 570 B.C. Take a short ferry ride to Malta and explore Valetta, the city's capital and a UNESCO World Heritage site. Stroll the Upper Barracca Gardens and discover the Palace of the Grand Masters and St.John's Co-Cathedral. Another ferry takes you to the tranquil island of Gozo where you can spend the day gazing upon the island's natural wonders.
Enjoy a personalized vacation that best suits your needs, developed by one of our experienced destination experts. Relax during your trip with our 24/7 support and expert local guidance.
Meet your driver for a private Airport (Falcone Borsellino) transfer with a private vehicle and driver. Please note drivers may or may not speak English as their sole responsibility is to transfer clients from one location to another. If you would like to have the presence of an English speaking Assistant or Guide for your transfer this can be pre-arranged upon request and would be subject to an additional supplement.
Meet your guide in your hotel lobby this morning to visit Palermo and Monreale. You'll be enchanted by Palermo's wide boulevards, traditional Sicilian Old Quarter, and baroque palaces. You'll see the city's main sights, including Quattro Canti (the Four Corners), an extravagant baroque square ringed by four buildings with baroque sculptures that depict the Four Seasons, Spanish kings, and the patron saints of Palermo's four old quarters. You'll also see the twelfth-century Cathedral, which houses a pantheon of royal tombs. Afterwards, you will be taken to Palermo's impressive food market Il Capo which is full of color and great epicurean delights. Be sure to sample some typical street food such as pani ca meusa, panelle and arancini while you are there!
Later you'll discover the Arab-Norman splendor of the Monreale Cathedral. This treasure dates from the 12th century and shows the diverse architectural influences of both the Normans and the Arab population. At day's end, you'll be returned to your hotel in Palermo by private vehicle.
Meet your English speaking driver for transfer to Agrigento, with a stop in Segesta. Upon arrival in Segesta enjoy a two hour tour with local expert. Visit the Doric Temple, one of the best preserved Greek temple in Europe. Segesta was one of the major cities of the Elmian people, located on a hill. The temple is simply beautiful situated on a rolling green countryside with views that stretch right down to the sea.
Mandranova Estate has a long tradition of specialized cultivations which has been passed from one generation to the next. Today, after a reclamation and cultivation, 40 hectares are dedicated to olive trees, with extremely innovative cultivation, gathering and processing systems. This morning you will be privy to a private tour of the farm including its olive grove, and oil press. After learning the process of making quality olive oil, taste some of the best Extra virgin Olive Oil made on the island.
Enjoy a private transfer and guided walking tour of Syracuse with your local English speaking guide. Notable for its rich Greek history, culture, amphitheatres, and architecture, this 2,700-year-old city played a key role in ancient times, when it was one of the major powers of the Mediterranean world. Explore the Old Town of Syracuse, with the 14th and 15th century palaces of Piazza Archimede, the ancient Temple of Apollo (built in 570 B.C.), the Foro Italico promenade, and the 17th century Cathedral which incorporates the remains of the ancient Temple of Athena. Afterward, you will get the chance to admire the historical centre of Noto, the Baroque capital of Sicily; a very beautiful town rebuilt as a baroque masterpiece following a 1693 AD earthquake which destroyed the town.
Meet your driver for a private transfer to Pozzallo Port.
Take the ferry for a transfer from Pozzalo to Valletta, Malta. The transfer should take approximately 1 1/2hrs.
Meet your driver and English speaking assistant for an airport transfer.
Enjoy a half day tour of Valletta with private vehicle and an English speaking guide. Valletta, Malta's capital and a World Heritage site, is nothing short of an open-air museum. It is a living experience of Baroque architecture, a monument donated by the Knights of St John nearly five centuries ago. The city owes both its name and its fortifications to Jean de la Valette, Grand Master of the Knights of St. John, who rebuilt the city after the Great Siege of 1565. After a morning at leisure you will go sightseeing in Valletta, visiting the Upper Barracca Gardens and two great buildings erected by the Knights of St. John, the Palace of the Grand Masters and St. John's Co-Cathedral. Entrance fees to St. John`s Co-Cathedral & Caravaggio, State Rooms and Tapestry Chamber included.
Enjoy a private full day tour with vehicle and English speaking guide. In the morning you drive inland to the village of Mosta, whose Church of St. Mary has the third largest unsupported dome in all of Europe. Continue on to Mdina, ancient capital of Malta, and a town of great historical charm, much of it painstakingly rebuilt after a devastating earthquake in 1693. Includes entrance fee to Mdina Cathedral.
Enjoy a private full day tour to Gozo with vehicle and an English speaking guide. You will take the ferry across for a day in Gozo, a tranquil island ringed with beautiful bays. Most of this island is rural but one still finds numerous archeological remains and architectural treasures, including the old Citadel and the Ggantija temples. You`ll visit the capital, Victoria, with its hilltop citadel, then see some of the island`s natural wonders: the Azure Window, an immense limestone arch created by erosion; Fungus Rock, whose plant life was harvested for medicinal purposes by the Knights of S. John and the Inland Sea. Includes English speaking guide, private vehicle, ferry tickets, entrance fees to Ggantija temples, Gozo Cathedral.
The Hotel Plaza Opera (4*) is conveniently located in Palermo close to shopping and business area. It is surrounded by fine restaurants and wine bars. Palermos main historical and artistic attractions are situated within walking distance. The Palermo hotel features a distinctive atmosphere and a warm Sicilian welcome awaits guests at their arrival. There are 47 rooms at the Hotel Plaza Opera including suites, single, double, twin and triple rooms. These rooms are fully equipped with modern amenities, including flat screen TV and broadband wireless internet access.
The Mandranova Estate (4*) holiday resort is set in a garden of palm trees and African plants. We offer a stay of absolute comfort and tranquility in the rustic simplicity of the old farmhouse and renovated rooms in a train station and an old millstone. The "Gebbia, formerly used for agricultural irrigation, has been transformed into a small but lovely pool where guests can go for a refreshing swim in the summer heat. The charming owners are renowned for the warmth of their welcome and wonderful sense of hospitality and the restaurant, which is for the exclusive use of guests, offers excellent food prepared with locally produced ingredients. For beach lovers, there are several nice sandy beaches nearby.
On the edge of the island of Ortigia, the Hotel Des Etrangers et Miramare (5*) is within easy walking distance of the centre of Syracuse. The hotel is made up of 78 guestrooms and 13 suites. The architecture is rather elegant, in a neoclassic Sicilian style. The floors are covered with precious marbles, while the walls and ceilings are enriched with stucco work. Most bedrooms open onto the Porto Grande sea. On the 6th floor, there is a restaurant that offers a panoramic view of the Ortigia rooftops, bell towers and the expansive sea below.
The Grand Hotel Excelsior (5*) is ideally located on the doorstep of a UNESCO World Heritage Site – the Capital City of Valletta, with all its major attractions, culture, art treasures, and historical architectural gems. This acclaimed Valletta Malta hotel prides itself in providing the discerning traveller with magnificent accommodation, breathtaking views of Marsamxett harbour and Manoel Island, and an unforgettable dining experience. Its central position allows for easy travel to all parts of the Maltese islands.
Vanessa Oquendo ,
April 21, 2014
"Melissa Field was extremely helpful! She was courteous, professional, knowledgeable, and friendly! She kept me updated on the status of everything and provided timely correspondence. She took ownership for any problems I had and remedied them. I had the most amazing time of my life in Iceland and Paris! I would not have experienced everything without the help of Kensington Tours."
Marilynn Weaver ,
April 21, 2014
"All of our guides were beyond fabulous! Our time in Dublin was much too short, would have loved to stay there at least one more full day. Would recommend extending this package to 15 days for any future visits. The train to Edinburgh was super! Beautiful scenery and great steak pies!"
Ann Saxon ,
November 06, 2013
"Our trip was fantastic!!! I cannot say enough good things. Lianne worked with our exact dates and time frame beautifully.Our drivers were prompt and friendly. The private guides were so knowledgeable. We left with an appreciation of the history, the culture, and the beauty of Andulasia. We were very pleased and will certainly recommend your company to friends and family."
Coby Scherr ,
November 05, 2013
"Everyone involved in our Portugal trip made it terrific. Exactly as advertised. Every event on time and most pleasant. Guides were well-informed, courteous and friendly. Really made for a great journey every time. Each hotel was clean, upgraded and staffed with knowledgeable and friendly folks. Breakfasts were complete -- almost too much to eat. It will always be a wonderful memory thanks to Kensington Tours."
Couples Dellinger & Hubbell ,
November 06, 2013
"We've been raving to everyone about the food, the friendliness of the people and the amazing history and sites in Turkey. Yes, we want to go back."
John Edstrom ,
October 22, 2013
"Overall, our tour in Spain was very enjoyable, and well planned and executed. Our private tour of the Alhambra was excellent. Virginia, tour guide for royal palace ruins outside of Cordoba, was also excellent. In Seville, we went to the Flamenco Show/dinner, and the Flamenco was outstanding!"
Kevin Wilshere ,
October 19, 2013
"Great trip to Spain! Thanks again for all your help, Lianne. The destinations, hotels, guides and everything were all top notch."
Chery Westlund ,
November 07, 2013
"My husband and I took a 3 week vacation to southern Europe and North Africa and had a great time. All the guides were very knowledgeable and bent over backwards to accommodate us. The arrangements made by Kensington went off without a hitch. This is our second trip with Kensington (we went to Peru in 2009) and we will certainly book with them again."
Randy Gramlich ,
October 07, 2013
"Thank you for your follow up, we both loved our time in Croatia. It's really a beautiful place, especially the coast. Your choice of hotels was great. It was an incredible view from the Bellevue hotel in Dubrovnik and the Vestibule in Split was in the best possible location. We were able to relax in our room listening to the wonderful singers in the courtyard and its central location made it so easy to walk anywhere we wanted to see with ease. "
Jay Steffan ,
September 24, 2013
"We just returned from a 10 day trip to Paris and Normandy. We spent three nights in Paris and then enjoyed a seven night cruise on the Seine to Normandy with AMA Waterways. The time in Paris was well spent and has piqued our interest to return for a more thorough visit. Guide Wafaa Lankey was superb in our visit to Versailles. The Seine cruise was relaxing and beautiful. So many wonderful little towns and we wished we had more time in each one to explore and enjoy.
We traveled to Croatia and Slovenia using Kensington earlier this year which was a fantastic trip."
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Android And Me
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My 30 Day Android Challenge…30 Days Completed
Screen Shot 2012-05-01 at 10.01.13 AM
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My 30 Day Android Challenge…30 Days Completed
Verizon XLTE service now live in 22 new markets
OnePlus One preorder system official, will go live in late October
Motorola, Verizon tipped to intro new Droid next month with fast charging as its focus
Sony isn't doing so hot these days, but it feels like they dug their own grave
Samsung Galaxy Note 4 preorders begin tomorrow, launch scheduled for October 17 [UPDATED]
Google: Android L will have data encryption on by default
Samsung Galaxy Alpha available from online retailer for $699.99
Android And Me
Android L will keep your device more secure by enabling encryption out of the box
Top 10 new Android games this week: Octagon, Hyper Trip
Google's insane new requirement forces app developers to list a physical address
XLTE-enabled Samsung Galaxy Tab S 10.5 now available from Verizon
Got your credit cards ready? Nexus 9 rumor gives us an October launch date
Qualcomm has shipped 1 billion Android devices with its processors inside
The new Moto X will not be available on the Sprint network
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iOS 8 Tips: How to install third-party keyboards like SwiftKey, Swype and Minuum
iOS 8 feature highlight: App Bundles
SwiftKey for iOS 8 surpasses 1 million downloads in 24 hours, hits no. 1 on App Store
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Espresso Machine and Coffee Maker Accessories
Brewing great coffee or pulling that perfect shot of crema starts with a great machine, perfectly roasted beans and pure water, but - as with all great things - the devil's in the details. That's where accessories from Seattle Coffee Gear come in!
Need a cup to hold your cuppa? A tamper to pat down your grounds? Or maybe you just need the collection of canisters it'll take to store your growing caffeine obsession? We have everything you need to complement your style of coffee consumption, right down to the best in cleaning products for whatever machine or system you have.
Bodum Classic Glass Tea Press with Stainless Steel Filter$49.95Loose leaf tea lovers take note! Bodum's Classic Glass teapot press has a patented design that completely stops the brewing process when the plunger is depressed. Learn More
Bodum Assam Tea Press with Handle$34.95The Bodum Assam Tea Press is designed to slowly release the hidden depths of your fine leaf teas. Add to that a removable stainless steel infuser and highly durable, heat-resistant Borosilicate glass and you've got an elegant and extremely functional teapot that has earned a place at the center of your tea table. Learn More
Sowden Penrose SoftBrew Tea Maker$39.95Like it's cousin the Sowden SoftBrew Coffee Maker, the Sowden Penrose SoftBrew Tea Maker uses the same innovative stainless steel filter that traps and contains loose leaf tea from getting into your ideal cup. Steeping the full flavor of your favorite leaves, the Penrose allows loose leaf tea to float within the filter for a full extraction. Once you've reached your desired strength, the micro-filter allows you to remove the leaves easily. Learn More
Frieling Creamer and Sugar Bowl Set
Regular Price: $75.00
Our Price: $70.95Gift giving made easy! The Frieling Creamer and Sugar Bowl Set with Tray makes a thoughtful gift for holidays, birthdays, anniversaries, showers, and as a hostess gift...perhaps bundled with their favorite illy Caffe. Made of mirror finish 18/10 stainless steel this set offers a lifetime of service. The 10 ounce creamer also doubles as a milk frothing pitcher. Mmmmm Breve Caffe anyone? Learn More
Out of Stock
Lino Cup and Saucer - Set of Two$29.95The Lino Cup and Saucer sets of two come in three perfect sizes: Espresso, Cappuccino and Latte! More than just a pretty porcelain mug, the cups were created with great care and attention to the sensory experience of drinking coffee. How the coffee is poured into the cup, how the handle feels in your hand and how your nose takes in the aroma were carefully considered in this collaboration between Seattle coffee lovers and Italian coffee roasters. Learn More
Cremaware Porcelain Cups$9.95Made of high quality porcelain, Cremaware Cups feature a unique curve designed to preserve crema and aid in latte art creation. The classic American diner brown and cream color combination will highlight the warmth of your favorite java beverage. Learn More
Milk to Perfection Latte Art Pitcher$34.95The key to fancy latte art patterns like rosettas or double ferns start with velvety smooth microfoam. It can take months to perfect your steaming technique using standard frothing pitchers, but the Milk to Perfection Latte Art Pitcher will make you a pro from day one. Learn More
Coffee Catcha Dosing Tool$79.00Make a mess when you grind into your portafilter? The Coffee Catcha tool is designed to keep coffee in your portafilter and off your counter top, preventing wastage and ensuring a consistent dose every time. Learn More
Espresso Dosing Tools - 3 Piece Set$36.95Scottie Callaghan, World Latte Art Champion, designed a set of dosing tools indispensable for cafe baristas and home baristas alike. Consistency is something every barista strives for, and now its easier than ever. The Espresso Dosing Tools Set makes grooming fresh fluffy espresso grinds in the portafilter basket easy to replicate time after time. This pairs well with the Coffee Catcha for a preparation with no fuss and no muss (and NO FINGERS in the mounded espresso.) Learn More
Capresso frothTEC Automatic Milk Frother
Regular Price: $130.00
Our Price: $99.99Now that you have your espresso shots pulled, what more do you need? Velvety warm frothy milk for a latte and clouds of fluffy foam for a cappuccino! The Capresso FrothTec Automatic Milk Frother offers easy prep for a variety of drinks. A heating disk warms the milk without the possibility of scalding it. Learn More


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The natural consequences made me laugh and reminded me of that episode of The Big Bang Theory where Sheldon keeps giving Penny chocolate every time she does something that he thinks is good.
We went to see Spider Man last night in 3D; it was strange because it was pretty much like the original Spider Man that Toby Maguire was in and they'd just put new actors in place. We'd gone with the drummer from Rich's band and his wife on a double date. It's the first double date we've ever been on and it was fun. Like Lily and Marshall from How I Met Your Mother, we may have found our double date partners. LOL.


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Cinco de Mayo Festival
IL IN WI Regional Catastrophic Planning Team
Sunday, May 5, 2013 from 12:30 PM to 9:00 PM (CDT)
Sycamore, IL
Who's Going
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3 of your friends are going. Share it to get more people on board! Share
Sara Haughty
San Francisco, California
San Francisco, California
Luke Picard
London, United Kingdom
London, United Kingdom
Rick Vespucio
Florence, Italy
Florence, Italy
Event Details
The Citizen Preparedness Campaign (Gear Up Get Ready) is seeking community volunteers to join us at local events to promote emergency preparedness through fun and engaging outreach activities.
WE NEED VOLUNTEERS to help enhance our impact into the community.
Volunteers will receive on-site training a half hour before the event and a Gear Up Get Ready T-shirt.
We are seeking individuals who possess some or all of the following qualities:
- sees the importance of individuals and families being prepared for emergencies
- willing to share preparedness information with individuals and groups in a public setting
- have basic knowledge of local emergency response resources
- able to work in a high energy, team setting toward a common goal
- comfortable with rallying others to take one emergency preparedness enhancing action such as completing an emergency contact card
Have questions about Cinco de Mayo Festival? Contact IL IN WI Regional Catastrophic Planning Team
When & Where
Taxco Restaurant
223 W State St
Sunday, May 5, 2013 from 12:30 PM to 9:00 PM (CDT)
Add to my calendar


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(reposting this here b/c I didn't get too many responses in other forum)
So we had unprotected sex this month. Not really TTC right now - but fine if it happens.
Anyway, having all the symptoms - sore boobs, hunger, tired, cramps, etc.
So I POS this morning even though I'm still 9-10 days away from my period.
I couldn't stand not knowing anymore.
And I could see the faintest of faint lines in the positive window. So I put it away to show my boyfriend later. When I took it back out it was positive!!?!?!
So we just had a big talk about another baby!
And then I POS - a new one. And it's totally negative.
How can that happen?
I mean - what would have made it turn to a blue line if I'm not preggo?


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Celebrate Spring with the Angels at Tempe Diablo Stadium
The Angels take on Cactus League opponents at intimate Tempe Diablo Stadium and you can be there to see them! The travel packages presented here take the true Angels fan into the heat of the action with great game tickets and an exclusive post-game dinner with select Angels players and team personnel. Packages also include your choice of accommodations, rental car with unlimited mileage, and a custom Angels sports merchandise package. So join us this spring in Tempe, Arizona and catch the beginning of what's sure to be another exciting season of Angels baseball!
|March 7 - March 9, 2014
|March 15 - March 17, 2014*
|*This departure does not include the post-game dinner with Angels players and personnel.
|March 21 - March 23, 2014


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Showing 1 - 4 of 4 Products
Model: DLS315 |
Catalog #: 55041141
Always know what's coming with the DLS315 from Kat.
Model: ESD7570 |
Catalog #: 55059021
The ESD 7570 is an affordable radar/laser detector with reliable and proven performance. The unit de...
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Model: LRM-360 |
Catalog #: 55044641
This Laser Module for Whistler's PRO-3600 is the perfect add-on to your high-performance laser/radar...
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Model: INTELLI-CABLE |
Catalog #: 55029965
Control it all at the touch of a button.
Online prices and product selection may vary from our retail stores. All prices and offers are subject to change. Copyright RadioShack Corporation 2014. All rights reserved.


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Showing 1 - 2 of 2 Products
Model: RMR-C475 |
Catalog #: 55041148
Always know what's coming with the RMR-C475 from Rocky Mountain Radar.
Model: RMR-C435 |
Catalog #: 55041145
Always know what's coming with the RMR-C435 from Rocky Mountain Radar.
Online prices and product selection may vary from our retail stores. All prices and offers are subject to change. Copyright RadioShack Corporation 2014. All rights reserved.


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Meet Up With Some Of The Best Looking Local Singles On WEB DATE Mobile At This Moment
Are you not having the time to date due to consistently being on the road? Do you think your social life has become a thing of the past because you clearly do not have any more time to make room in your private life? At this moment is the time for you to go ahead hooking up again and stop being a bitter single. With WebDate Dating Site you will be able to put together a dating profile, share photo galleries, send emails, instant message and filter through thousands of other users pages. This adult dating mobile site is sure to have what you are searching for in a potential date. What you have to do is sign up and become an active member.
Signing up is effortless and you can do it on your mobile device at any time. Once you have completed your profile you will be able to link up with thousands of other users in your location. You are the only one in charge of your social life and you can no longer use the excuse of being overwhelmed with a career, going to school or children any longer. There is no reason why you should feel that you can't have a personal life and mainly if you have access to WEB DATE Mobile at your finger tips. Mingle with the person of your dreams tonight on WEB DATE Mobile!


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This regal design highlights the center gemstone in an intricate elevated crown setting. This ring is particularly stunning from the side. See Details
Gemvara jewelry is truly personal: you design it, choosing gems and metals to celebrate your story, and we craft it just for you. We'd love to help you find your perfect piece! (more)What quality are your gemstones?
They are all-natural and hand selected fine quality. (more)


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Women's adidas Originals
mi adilette Custom Slides
Product Information
Men's sizing. We recommend women order one size down. Why mess with history? The adilette has been styling and chilling since 1972 and is the world's most famous sport slide. Keep your feet laid-back and happy with comfortable slip-on style, synthetic upper, quick-drying textile lining, and contoured footbed.
- Synthetic upper for durability and quick drying
- Comfortable contoured footbed
- Textile lining for comfort
- Imported


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This modern, sleek solitaire ring has a large round brilliant cut gem center stage in crisscrossed four prong setting. A contemporary take on a classic style, this ring design is available in different band width and gemstone sizes. See Details
Gemvara jewelry is truly personal: you design it, choosing gems and metals to celebrate your story, and we craft it just for you. We'd love to help you find your perfect piece! (more)What quality are your gemstones?
They are all-natural and hand selected fine quality. (more)


text: Warning: mysql_result(): Unable to jump to row 0 on MySQL result index 19 in /usr/local/wwwdocs/motorbase-production/libs/Classifieds.php on line 345 - Motorbase Make/Model of Car Classified Picture Car Club Shop Home Car Profiles There are 1463 manufacturers and 6749 models of car within Motorbase Car Profiles Search Browse Manufacturers Search for make/model Latest Updates Ford (USA) V8-91 Ford (USA) V8-81 Ford (USA) V8-78 Most Popular Makes Abarth AC Alfa Romeo American Motors Corporation - AMC Aston Martin Audi Austin BMW Buick Cadillac Chevrolet Chrysler USA Citroen Daimler Dodge Ferrari Fiat Ford Ford (USA) Hillman Honda Humber Jaguar Lancia Land Rover Lotus Mazda Mercedes-Benz MG Mitsubishi Morris Nissan Opel Packard Peugeot Pontiac Porsche Renault Rover Singer Standard Studebaker Sunbeam Toyota Triumph TVR Vauxhall Volkswagen Volvo Wolseley Browse... Photo Gallery There are 110480 pictures in the Motorbase archive Photo Gallery Search for picture Submit a picture Latest Pictures Directory Directory Clubs and Places of Interest Car Clubs Museums Shows & Exhibitions Travel & Tours Dealers and Suppliers Automobilia/Book publishers Breakdown Services Breakers/Salvage Car Hire Dealers Garage Services Insurance/Finance Parking Services Parts and Supplies Search the Net Transportation/Storage Market-place Help to support Motorbase, shop from our sister site Bookbase. Market-place Cars for Sale Classifieds Auctions Forthcoming Sales Results From Past Sales Search for auction lot Auction Houses Bookbase - The Motoring Bookshop Search by manufacturer Engines Tuning & Performance Restoration Offroading American Autos Hot Rods & Custom Cars Motorsport Magazines Posters & Prints Motorcycles Commercials Tractors Military Railways Aviation Personalities Other Titles More... More Goodies Books & Magazines Search book archive Search magazine archive Readers Gallery Browse readers cars Add your car Contact Us Sign in Price POA Contact Click here for full advert [Return to listings] Motorbase.com Contact US Terms and Conditions Privacy Policy Research News Archive RSS Feed Site developed by: Coreware ©1998-2010 Classic Vehicles Limited Company Registration No.3840299 Reg. office: 20 Havelock Road, Hastings, TN34 1BP, United Kingdom


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Welcome to the January Scraplift Challenge.
This beautiful page "Granada" by Chrysettellevandyk is our model.
Stop by her gallery and leave her some love by clicking on the image above.
Remember, you can turn it, twist it, or do whatever it takes to make the scraplift your own creation.
The rules for the challenge
(1) Your layout must be unique, and can only be used for this challenge.
(2) Your layout also counts as one entry towards the January Scrappin' 7 Challenge.
(3) Use of GDS products is strongly encouraged and greatly appreciated.
(4) Please post your layout in the Scraplift Challenge Gallery HERE
(5) Come back here and post an image of what you created, and link it to the gallery, so we can all leave you some love!
I will have a bonus for all who particiapte in this challenge by posting and linking their creations here. Please be sure to credit the designer's kit/s when you post to the gallery.
This challenge runs through January 31.
Do you all know how to link your images back to the gallery? .. If not, have a look HERE
Also... here's how to assign keywords to your layouts to give the credit back to the designer.


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I am excited to announce that Josh and I are expecting our 2nd baby in late October/early November.
I'm 13 weeks along and feeling good. Started out a little rougher than when I was pregnant with Mia, but I'm starting to get some energy back and I'm over the nausea. Unfortunately I've been getting headaches a lot lately. I have suffered from migraines since I was a teenager, but when I got pregnant with Mia they went away and I hardly had headaches since, but they're back! I had a migraine so bad a couple weekends ago that I almost couldn't get up and around. My doctor said it's pretty common for women at the beginning of the 2nd trimester to get headaches so he gave me a prescription to take if they get really bad otherwise just Tylenol.
So far so good. As you can see I'm showing already so my wardrobe is shrinking quickly. Too small for maternity clothes and too big for many of my regular clothes. It's not real obvious yet so people just think you're fat. This stage is a bummer, but it won't last long. Everyone keeps telling me you get so much bigger so much faster with baby number 2.


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Next, you'll be asked to connect with Twitter. Rest assured, we will never send a tweet from your account
without your permission.
We will send you an email with an invite soon.
RT @steve4good: Thrilled to have led the development of a new #spiritof2012 Legacy project @BritainsPB supported by @BigLotteryFund:
RT @DCMS: .@sebcoe "The #inspiredby2012 brand is a great way to give projects a link to each other and the Games' legacy."
RT @DCMS: The new #inspiredby2012 mark will celebrate the projects that make up the #London2012 legacy:
We're now tweeting as Inspired by 2012 - for all the latest on the legacy of the 2012 Olympics
RT @DCMS: Olympic champ @JoannaRowsell joins @Maria_MillerMP to launch the #inspiredby2012 mark. @sportivate_se 1st recipient.
RT @DCMS: Pro basketball team @London_Lions visit their new home at the CopperBox in the #Olympic Pk. Full story and pic on FB
RT @DCMS: .@JoannaRowsell: "It's fantastic that @Sportivate_se is helping so many young people to discover a new sport." #inspiredby2012
RT @MinisterDisPpl: Tomorrow marks 6 months since #Paralympics closing ceremony. #Disabledpeople can try a sport at #Sportfest next month
RT @DCMS: Women playing more sport than ever, but still not enough female reps on nat'l gov bodies, says @Maria_MillerMP #IWD
Follow @2012govuk on Twitter


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Kleer-Guard - Stretch-Pro - 10" x 1000' - 4 rolls
by Kleer-Guard | Item #: 729668 |Model #: PRO10SAMS |
This 10" eco stretch film includes 2 sets of tension control handles.
Stretch-Pro® is an Eco-friendly 5-layer cast micron film. Compared to conventional 80 gauge film Stretch-Pro® is a stronger, thinner film that produces 40% less waste, a 25% higher load capacity, requiring fewer wraps and has 50% higher tear resistance.
Stretch-Pro® comes with reusable tension controlled handles, making it the easiest way to wrap or bundle items for moving and storage. This film clings only to itself and leaves no adhesive residue behind after unwrapping. Whether you are using Stretch-Pro in the office or at home, just a few wraps with our film will make bundling a breeze.
Assembled Country
Component Country
USA And Imported
Ask & Answer
Warranty Information1 year
There is no additional information available for this item.


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Don't Have an Account? Join the IHG® Rewards Club
Redeem when you want, for what you want. Your points never expire and there are no blackout dates.
Reward Nights
When redeeming points for a Reward Night, you may only book one room at a time.
Once you complete your Reward Night reservation you will be given the option to duplicate this reservation.
* Requires affiliation in the respective organization.
** Best Available Rate Search does not include affiliation rates.
To book more than 9 rooms for one stay or request a quote, please use our Easy Meetings tool or call 1-800-MEETING (in United States, Mexico and Canada).
Centrally located in the heart of New Jersey, the Crowne Plaza Monroe South Brunswick offers great accommodations off the New Jersey Turnpike. We are minutes from Princeton and New Brunswick and situated between New York City and Philadelphia.
Business travelers in the know choose the Crowne Plaza Monroe South Brunswick when visiting NJ. Our hotel's location is near top companies, including Canon, Hyundai, Audi and Home
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Business travelers in the know choose the Crowne Plaza Monroe South Brunswick when visiting NJ. Our hotel's location is near top companies, including Canon, Hyundai, Audi and Home Depot. As "the Place to Meet," we have more than 14,000 sq ft of space and everything you need for a perfect meeting, from a 2 hour RFP response guarantee to a Daily Meeting Debrief. Free WiFi access throughout the hotel and a Business Center help you stay productive.
There are plenty of things to see and do in the surrounding towns of Cranbury, Princeton and New Brunswick, NJ. Our hotel is minutes from Englishtown Raceway Park, historic Rutgers and Princeton universities and Six Flags Great Adventure. Since we are conveniently located off I 95, day trips to New York City and Philadelphia are only an hour away.
Our New Brunswick, NJ area hotel aims to make your stay as comfortable as possible by offering exquisite amenities, including a heated, indoor pool and a Fitness Center. Enjoy a delicious meal at Yogi's All American Grill and Sports Bar. With the Crowne Plaza Sleep Advantage Program, featuring comfortable beds, you can wake up refreshed each morning.
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We promise you access to the guaranteed best available prices, or your first night is free.
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We do not charge any booking fees for making reservations directly with us.
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IHG takes your privacy seriously and works to protect you. All personal information you provide is encrypted and secure.
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Tag Archives: www.woolworths.com
Top Employers in Australia
If you are immigrant migrating to Australia as a skilled migrant, this blog is for you. It is better that you get to know about the top employers and companies in Australia. This would help you to better understand the significance of your industry in the new country. In addition, you would also know of your chances with reference to the job market.
Below is the list of the top 10 employers in Australia.
- Woolworths – http://www.woolworths.com.au/
- Coles Myer – http://www.colesgroup.com.au/Home/
- Queensland Health – http://www.health.qld.gov.au/
- Telstra – http://www.telstra.com.au/
- National Australia Bank – http://www.nab.com.au/
- ANZ Banking Group – http://www.anz.com/personal/
- Australia Post – http://www.auspost.com.au/
- Qantas – www.qantas.com.au/
- BHP Billiton – http://www.bhpbilliton.com/bb/home.jsp
- Commonwealth Bank – http://www.commbank.com.au/
The above information has been taken from MyCareer. To know more on the recruiting trends and other top employers in Australia, visit http://newsletter.mycareer.com.au/general/nov2006/job-update/section/thomson.aspx.
These recruitment trends would help you design an appropriate resume as desired by the Australian employers. In addition, you would be better prepared to attend a job interview over there.
Above all, it is best to contact an Immigration and Visa Consultant who is equipped with the latest in this regard.


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Red Meat, Energy Drinks Share Heart-Disease Culprit
(NEWSER) – Bad news for steak and energy-drink lovers: A new study published in Nature Medicine finds they share a common ingredient that leads to heart disease, the Wall Street Journal reports. Carnitine, a compound that helps the body metabolize fatty acids, is plentiful in red meat and is often found in energy drinks and dietary supplements. Researchers believe that bodies may be converting carnitine into TMAO, a compound that can thicken the walls of arteries. They found that the more TMAO in a person's bloodstream, the more likely they were to suffer heart disease, a heart attack, stroke, and death.


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I'm enjoying your challenge. Here's the link to my LO:
Thank you for hosting,
I'm enjoying your challenge. Here's the link to my LO:
Thank you for hosting,
Here is my Step 1
I proudly help create for: Angelique's Scraps , Bee creations, Desclics, Ilonka's Scrapbook designs, JuliEnriquez Designs ,Kastagnette , kittyscrap , Krysty Scrap Designs, Laitha's Designs, Le petit Scrap, lins creations, Lady R designs, Marta van Eck, Pat's Scrap, S Designs, Sarayane, Scrap'Angie, Stephy Scrap, E-scape and scrap, and Pickleberry pop
pinterst: http://pinterest.com/zanthia5/ scrap stacks : http://scrapstacks.com/zanthia
Hopefully I just squeezed in. I lost track of my days!
Step Two:
2. Select a very lightly textured paper with a very slight pattern that compliments your background. If your paper is 12 x 12, reduce it to 11 x 11 and center it. Now use your warp tool to skew the edges so that the entire page looks like it's got a slight "S" shape. Now poke 3 to 5 varying sizes of shape holes of your choice along the center line keeping the "S" shape in mind. Use the tutorial I posted last month to help you poke the holes and add shadows if you like.
Post your layout by Wednesday, September 12 2012 The next step will be posted Thursday, September 13 2012
OK, Help!!!!
I use PSE 7. I see nothing named a Warp Tool. I also checked my CS3, and there is no Warp tool there.
Tuts or more info is definitely needed here! PLEASE!
No warp tool in PSE, in CS, if you use your move tool to transform, reduce the size to 11" x 11", don't accept the move yet... right click inside the paper, and one of the choices is warp. Click somewhere inside the grid and drag it, this will warp the paper. If you don't like what you did, just click the circle with the line through it, up by the checkmark so it will go back to the original state. I'm not sure if this is available in CS3 or not. I have CS5.1.
Store | Gallery | Facebook Fan Page | Blog
Thanks Patty. You are always coming to my resuce!
I will go see if I can figure it out!
Store | Gallery | Facebook Fan Page | Blog


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23 Customer Review
Availability: In stock | Usually dispatched within 24 hours
Vittoria Rubino Pro Clincher Road Tyre offers durability, comfort and safety. It features 150 TPI nylon casing, technical tread pattern, long wearing tread compound and excellent puncture protection. Rubino Pro is perfect as a training, racing or commuting tyre. - A.D.
Key Features:
If ordered before 8pm, delivered by courier next working day. Available on orders placed before 8pm (2pm weekends and Bank Holidays) for delivery next business day. Applies to most delivery addresses within mainland UK.
Please check the stock availability notice on your item when placing your order. This item is: In stock | Usually dispatched within 24 hours
Please remember to add postal time (2-3 working days) to obtain a complete estimate of delivery to your door.
You will receive an email to confirm when your item has been sent.
You can also check the status of your order and individual items by accessing your account details and following the prompts.
Please allow 10 working days from dispatch of your order before notifying us of any late deliveries.
It may be advisable to check with your neighbours to see if a parcel has been left with them, check any outhouses you might have where it may be left if it cannot fit through your letterbox and contact your local sorting office to see if the item has been returned to the depot as undelivered and awaiting collection.
Please see our returns policy.
If you have any technical queries please visit the PBK Forum where our experts are waiting to answer your questions.
No more then 1000 characters long please.
Vittoria Diamante Pro III Radiale Clincher Road Tyre
Save: 44%
Vittoria Ultralite Road Inner Tube - 650 x 19-23mm
Save: 34%
Vittoria Rubino Pro Slick Clincher Road Tyre
Save: 31%
(23 Reviews)
Write a review to be in with the chance to win a $130 voucher to spend on ProBikeKit
Reviewed on 22/07/2014 by Bill S.
I've had excellent luck with Rubino Pros, regular and "slicks". Fairly light, long wearing, handle well. Current ones I'm running have the blue sidewalls, and they're going strong after well over 1200 miles (not a single flat, knock on carbon). No complaints with these tires at all!
Reviewed on 30/06/2014 by Ruly
This are the best tires for training. I'm bee using 700x25mm and love it.
Reviewed on 30/01/2014 by Thor Buddox, Road Cyclist
Solid performing, reasonably priced tire... a bit of traction on wet roads... a good choice for all but flat out racing.
Reviewed on 06/01/2014 by Swordsal
These tires are fantastic. They have held up through 5,000 miles and not one flat from a puncture. The color options are awesome, and it's a great all around tire. I had a set that I used for racing and a set I used for training, you can't go wrong with a set of these tires. I highly recommend them.
Reviewed on 05/01/2014 by Gerry
1 out of
1 customer
found this review helpful
This is an outstanding tire at a great price that offers cyclists durability, dependability and Italian tradition. While not the lightest clincher tire on the market, its few extra ounces make little difference when one considers the tire's overall performance and longevity. I have been especially impressed with the tire's cornering ability in all types of weather. A great buy. A great ride.
Reviewed on 05/01/2014 by Avionics
Great tire at a great price. Tires came in the manufactures box and arrived in the state in about two weeks. Great buying experience and will by from again.
Reviewed on 20/12/2013 by ScottyCycles
I've been riding on these tires for many years. I've always found them to be very durable (puncture resistant) and with a low rolling resistance. They corner well at high speed and even on wet roads. If you are looking for the best "bang for the buck" go with the Rubino Pro's.
Reviewed on 23/11/2013 by Kirk
Solid training tires.
Reviewed on 15/11/2013 by andrei
Great tires, highly recommended, hardly any flats, biggest bang for your buck
Reviewed on 12/11/2013 by Joeban1
The Vittoria Rubino Pro tires are good quailty and easy to change.
Vittoria Rubino Pro Clincher Road Tyre
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Book a flight from country A to country B, while you are in country C? On KLM.com, you can!
This year, Holland's capital will be host to many venues' milestones and celebrations, and KLM is proud to be part of it all. Don't miss the festivities — it starts on board with us!
For another 25 years may KLM may continue to carry its Royal Crown.
Sit back and relax… and relax some more with our stress-free destination inspiration and more in KLM's interactive e-magazine iFly.
Find out who will be on board on any KLM flight to and from Amsterdam.


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Narrow your search
Back up and restore photos, music, videos, documents, hard disk and partition.
The devices on this page represent the best among their respective categories.
Fast and affordable, the Seagate Backup Plus Slim is one of the best deals on the market for those who want lots of storage space on the go.
The Backup Plus Fast is an excellent choice for anyone, especially those for those needing lots of storage space or the ability to edit videos on the go.
Fast and massive, the Seagate Backup Plus Desktop is an excellent backup drive for any USB 3.0-enabled computer or server.
Seagate Backup Plus carries the flexibility of the GoFlex portable drive while adding performance and style to portable storage. The new drive makes an excellent buy.
Provided you can afford it and it's compatible with your gadgets, the PowerMat Dual 1850 Rechargeable Backup Battery is a fresh, efficient, and convenient way to charge multiple devices when at home and on the go.
If you're willing to dig a hole in your wallet, the Lexar Echo MX could be a great option for quick backups and on-the-go storage.
The Backup-Pal offers a convenient and user-friendly way to back up your cell phone contacts.
Pricing not available
The affordable Seagate Central delivers as a fast and easy-to-use network storage device for home backup and entertainment purposes.
Small business and personal users with large amounts of data will appreciate the Clickfree's painless backup drive that practically automates all the work through the embedded software. People running older Windows operating systems are out of luck, but the lightning-fast transfer speeds and excellent performance scores secure the Clickfree a solid recommendation for up-to-date Windows and Mac users.
Thanks to its compact physical size and bundled software, the WD My Passport Edge is a very good companion for mobile users.


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Gefitinib Use Plummets Following ISEL Trial Results
More than 85 percent of clinical oncologists who treat lung cancer patients have modified their care patterns based on the results of a clinical trial that showed the targeted agent gefitinib (Iressa) failed to improve survival compared with placebo. At a meeting of the Food and Drug Administration (FDA) Oncology Drugs Advisory Committee last week, officials from the drug's manufacturer, AstraZeneca PLC, reported the data, along with additional market research on gefitinib use since the company issued a "Dear Doctor" letter on Dec. 17, 2004 and other communications describing the trial's overall survival results.
"Physicians are aware of the [trial] results and are no longer selecting Iressa as their EGFR inhibitor of choice," said Carolyn Fitzsimons, an executive director with AstraZeneca. "They are choosing erlotinib (Tarceva)."
In the Iressa Survival Evaluation in Lung cancer (ISEL) trial, gefitinib was tested as a second- or third-line therapy in nearly 1,700 patients with advanced non-small-cell lung cancer (NSCLC). AstraZeneca officials presented further data from ISEL during the advisory committee meeting, including subset analyses revealing a significant survival advantage with gefitinib in never smokers and patients of "Asian ethnicity." Read more
Clinical Proteomics: Developing Standardized Tools
for Cancer Research
Diagnosing cancer as early in its course as possible and developing targeted drugs for treatment result in better clinical outcomes for patients. However, the development of effective tools that enable early diagnosis and targeted therapies has been an elusive endgame. Using proteins as biomarkers has long been considered a promising clinical diagnostics approach for drug discovery and development. Some biomarkers, such as prostate-specific antigen, have been in use for many years. Many other potential biomarkers are being reported in the literature almost weekly, although few have been translated into the diagnostic arena.
In short, our progress has not been as rapid as we would like, especially given the advances in our understanding of the process by which cancer develops and becomes lethal. I believe this is about to change. This morning, in fact, during a meeting of the NCI Board of Scientific Advisors (BSA), there was rich discussion about improving both the efficiency and effectiveness of proteomic biomarker research in the United States. Specifically discussed were the need to develop animal correlates, to integrate and align existing resources such as biorepositories, and to leverage knowledge gained from work with tumors where the biology is known and apply this to the complex proteomics of serum and other body fluids. Read more
Gefitinib Use Plummets Following ISEL Trial Results
More than 85 percent of clinical oncologists who treat lung cancer patients have modified their care patterns based on the results of a clinical trial that showed the targeted agent gefitinib (Iressa) failed to improve survival compared with placebo. At a meeting of the Food and Drug Administration (FDA) Oncology Drugs Advisory Committee last week, officials from the drug's manufacturer, AstraZeneca PLC, reported the data, along with additional market research on gefitinib use since the company issued a "Dear Doctor" letter on Dec. 17, 2004 and other communications describing the trial's overall survival results.
"Physicians are aware of the [trial] results and are no longer selecting Iressa as their EGFR inhibitor of choice," said Carolyn Fitzsimons, an executive director with AstraZeneca. "They are choosing erlotinib (Tarceva)."
In the Iressa Survival Evaluation in Lung cancer (ISEL) trial, gefitinib was tested as a second- or third-line therapy in nearly 1,700 patients with advanced non-small-cell lung cancer (NSCLC). AstraZeneca officials presented further data from ISEL during the advisory committee meeting, including subset analyses revealing a significant survival advantage with gefitinib in never smokers and patients of "Asian ethnicity."
These latter findings are consistent with previous studies of gefitinib, and represent a "real effect of the drug," argued AstraZeneca's Dr. Kevin Carroll. Many committee members agreed that some patients clearly benefit from gefitinib. Several others commented that the trial, while it did not meet its primary endpoint, was, as one member put it, "as close to a positive trial as you can get."
As for the subset analyses - which were not a prespecified component of the trial - a negative result in the overall population can cloud the accuracy of subsequent subset analyses, said Dr. Janet Dancey, a senior investigator in the NCI Cancer Therapy Evaluation Program. "The more subset analyses that are done, the more likely is the chance that positive results will be seen," she said. "However," she continued, "there are data from other studies which also show benefit in these subgroups, raising the probability that the beneficial effects seen in never smokers and patients with East Asian ethnicity are true."
The ISEL trial was one of several post-market trials required of AstraZeneca under the accelerated approval mechanism used by FDA to approve gefitinib in May 2003 - an approval granted solely based on the agent's ability to shrink tumors in a small percentage of patients. The follow-up studies - one has been abandoned; the other, which is pitting gefitinib against docetaxel, is ongoing - were required to show whether gefitinib could extend survival. Although gefitinib fell short in ISEL, both erlotinib and pemetrexed (Alimta) have proven in clinical trials to improve survival in patients with advanced lung cancer who have previously received chemotherapy.
The committee generally agreed that AstraZeneca had done a good job of communicating the preliminary ISEL results to the oncology community, including the "Dear Doctor" letter, which advised clinicians "to consider other treatment options in the recurrent [NSCLC] patient population." According to AstraZeneca's market research, 78 percent of clinical oncologists were familiar with the letter and 86 percent said they had modified their treatment practice as a result.
Dr. Richard Pazdur, director of FDA's Division of Oncology Drug Products, said the agency will not make a decision on gefitinib's fate in the marketplace until the final ISEL data are reviewed. The final trial data, including an analysis of survival in relation to EGFR expression and mutation status - potential indicators of patient response to the drug - will be available by June, AstraZeneca officials said.
By Carmen Phillips
Clinical Proteomics: Developing Standardized Tools
for Cancer Research
Diagnosing cancer as early in its course as possible and developing targeted drugs for treatment result in better clinical outcomes for patients. However, the development of effective tools that enable early diagnosis and targeted therapies has been an elusive endgame. Using proteins as biomarkers has long been considered a promising clinical diagnostics approach for drug discovery and development. Some biomarkers, such as prostate-specific antigen, have been in use for many years. Many other potential biomarkers are being reported in the literature almost weekly, although few have been translated into the diagnostic arena.
In short, our progress has not been as rapid as we would like, especially given the advances in our understanding of the process by which cancer develops and becomes lethal. I believe this is about to change. This morning, in fact, during a meeting of the NCI Board of Scientific Advisors (BSA), there was rich discussion about improving both the efficiency and effectiveness of proteomic biomarker research in the United States. Specifically discussed were the need to develop animal correlates, to integrate and align existing resources such as biorepositories, and to leverage knowledge gained from work with tumors where the biology is known and apply this to the complex proteomics of serum and other body fluids.
Over the past 2 years, we have conducted an extensive planning process, analyzing U.S. and international proteomics programs, resources, and capabilities; conducting symposia with thought leaders; and seeking other disease models as possible guides for future NCI activities.
What has emerged is a consensus that, while proteins are critical to future progress in cancer biology, we will not realize clinical applications unless we take action. There is clearly the opportunity to apply biomarkers to support a host of clinical tools and capabilities, from early detection to molecular imaging probe and sensor development, to drug discovery, to rationally developed and conducted clinical trials.
As many researchers have pointed out, the field has been handicapped by barriers related to technology, reagents, bioinformatics, and systems. In particular, there is a lack of standard protocols and internal standards for current technologies to enable reproducibility of researchers' work. We also are faced with the enormous biological diversity, range, and dynamic nature of the proteins that we are attempting to measure. Other issues, like the insufficient supply of biospecimens specifically collected for protein analysis and variable approaches for data capture, analysis, and management also have slowed progress. Overall, we have heard repeatedly that what's needed is a coordinated system that no single academic or commercial entity is in a position to develop and operate.
Today, the BSA deferred action in order to further refine and develop the proposal. NCI is committed to removing barriers to success. We will continue to develop and integrate our proteomic initiatives. We plan to develop a coordinated proteomics technology development system that will provide the cancer research community with the technologies, reagents, standards, bioinformatics platforms, databases, and other resources necessary to systematically discover cancer biomarkers - in effect, to build the "base of a pyramid" that will be the foundation of the clinical development of biomarkers for early detection and diagnosis. This system will be managed with specific program milestones to ensure the best use of resources and progress.
This has been a true team effort, coupling the work of NCI staff and some of the cancer's community most eminent researchers. We look forward to continued discussions with experts and advisors around the country as we further develop this vision.
Dr. Andrew C. von Eschenbach
Rapid Advances in Overcoming Drug Resistance to Molecularly Targeted Therapies
Virtually every oncologist has been faced with a patient who developed resistance to a chemotherapy treatment that had been working - this is called acquired drug resistance. Targeted therapies are not immune to this phenomenon, including the most successful targeted agent, imatinib (Gleevec).
The FDA's approval of imatinib for the treatment of chronic myeloid leukemia (CML) in 2001 launched the era of targeted therapy for cancer treatment. The drug directly inhibits an abnormal protein tyrosine kinase on white blood cells called BCR-ABL that, instead of regulating cell growth, remains continually active, fueling uncontrolled cancer cell growth in this form of leukemia.
"Many patients who initially respond well to imatinib therapy are at risk of developing resistance to the drug and suffering relapse - even those whose disease may appear to be in complete remission," explains Dr. R. Allan Mufson, chief of the Cancer Immunology and Hematology Branch in NCI's Division of Cancer Biology. Resistance comes on, Dr. Mufson adds, as the leukemia cells begin to derive mutations in BCR-ABL that prevent the drug from binding, rendering it impotent.
"We now know of over 30 different mutations that can cause BCR-ABL to become resistant to imatinib," says Dr. Charles Sawyers of UCLA's Jonsson Cancer Center. "In patients with newly diagnosed disease, we are seeing resistance to imatinib in about 4 percent of patients per year. The further the disease has progressed before initiating imatinib treatment, the greater the chances are that resistance will arise."
In many cases, practicing oncologists whose patients become resistant to chemotherapy have few, if any, options to combat the problem. But that's beginning to change. Recent advances in understanding the molecular basis of many cancers are allowing researchers to reverse engineer therapeutics by identifying the source of resistance and developing agents to combat it. The rapid development and testing of several second-generation therapies aimed at overcoming imatinib resistance is a case in point.
Studies on two new compounds - BMS354825 and AMN107 - have generated excitement. Like imatinib, both agents inhibit the aberrant function of the BCR-ABL kinase. Bristol-Myers Squibb (BMS) was already developing BMS354825 to inhibit a closely related kinase in solid tumors. Following Dr. Sawyers' presentation at a scientific conference on potential methods to combat imatinib resistance, BMS officials contacted him to see if their agent might fit the bill. AMN107, on the other hand, was specifically designed by Novartis to overcome imatinib resistance based on their studies of the molecular interactions between BCR-ABL and imatinib. Both new drugs are less specific than imatinib, which allows them to bind and inhibit many imatinib-resistant mutants. They are also more potent than imatinib, meaning less of the drug is needed to cause the same biological effect.
"Preclinical studies show BMS354825 is about 300 times more potent than imatinib, and AMN107 is about 20 times more potent than imatinib," says Dr. Sawyers.
Last summer, Dr. Sawyers and colleagues published a report in Science on their preclinical studies with BMS354825. The drug, they reported, was effective against 14 of the 15 different imatinib-resistant mutations tested, and significantly prolonged the survival of mice with CML.
Based on these studies, BMS began a phase I clinical trial in conjunction with Dr. Sawyers and Dr. Moshe Talpaz at M.D. Anderson Cancer Center. Preliminary trial results, reported in December 2004 at the American Society of Hematology Annual Meeting, showed that BMS354825 overcame imatinib resistance in 31 of 36 patients.
"We have seen outstanding responses with no side effects in patients with all phases of the disease," comments Dr. Hagop Kantarjian, another clinician involved in the clinical trial and principal investigator of the leukemia-focused NCI Specialized Program of Research Excellence at M.D. Anderson.
While the phase I trial with BMS354825 is almost complete, Dr. Sawyers explains, "Our results to date are so promising that we have already begun the phase II portion."
Preliminary results from the phase I trial testing AMN107 in patients with imatinib-resistant disease show no adverse effects in any of the 95 patients treated, says Dr. Kantarjian, who also is involved in trials developing that agent. "Most of our patients are in later stages of the disease, and we are getting an early response rate of about 50-60 percent." Currently researchers are correlating responses with particular BCR-ABL mutations and trying to determine the optimal dose for the phase II portion of the study.
"Both BMS354825 and AMN 107 seem to have similar clinical potency. These new drugs pave the way for designer cancer treatments that could be used as second-line therapies for those who develop resistance to imatinib," says Dr. Kantarjian. "Alternatively, these drugs could be administered as an initial kinase inhibitor cocktail to prevent the development of resistance to any of the particular drugs - akin to how protease inhibitor cocktails are used to treat HIV."
By Sunil Jani
Adjuvant Chemo Works Equally Well in Older Women
Women over the age of 65 who have lymph node-positive breast cancer but are otherwise in good health can benefit from adjuvant chemotherapy just as much as younger women, according to a study published in the March 2 Journal of the American Medical Association.
The research team reviewed data from 4 clinical trials that collectively enrolled more than 6,000 women. They found that women over age 65 had more lymph nodes positive for cancer and a higher rate of treatment-related mortality than did younger women, but that age had no relationship to the positive effects of chemotherapy and tamoxifen on disease-free and overall survival.
The authors stress that elderly cancer patients may experience age discrimination from health care providers and family members who fear that they are too frail for the toxic effects of chemotherapy. This is underscored by the fact that only 8 percent of patients enrolled in the 4 studies analyzed were aged 65 or older, though about half of new breast cancer diagnoses occur in women in this age group.
The authors caution that not all older patients are good candidates for chemotherapy, and cite www.adjuvantonline.com as a model for healthcare providers to use in estimating the benefit of adjuvant chemotherapy for these women.
High Blood Levels of Vitamin E Linked to a Lower
Men with higher levels of vitamin E in their blood were found to have a lower risk of developing prostate cancer, according to a report in the March 2 Journal of the National Cancer Institute.
The study was led by Drs. Stephanie J. Weinstein and Demetrius Albanes of NCI's Division of Cancer Epidemiology and Genetics. They conducted a case-control analysis of 300 men from the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) trial of nearly 30,000 Finnish participants. The ATBC trial had previously shown that men who took vitamin E supplements had a 32 percent lower incidence of prostate cancer than those who did not.
For the current report, the scientists measured for the two principal forms of vitamin E - alpha-tocopherol and gamma-tocopherol - in the baseline serum before the men took vitamin E pills. Men with the highest baseline levels of alpha-tocopherol had a 53 percent reduction in risk and those with the highest levels of gamma-tocopherol had a 39 percent reduction in risk.
"These data reinforce the protective relationship seen in the ATBC trial for alpha-tocopherol," said Dr. Weinstein. "They also suggest that the other major form of vitamin E - gamma-tocopherol - may also inhibit prostate carcinogenesis."
Dr. Albanes noted that the findings "should be reassuring" for the SELECT trial, which is testing the effects of alpha-tocopherol and selenium supplements in prostate cancer prevention, because "we saw stronger inverse associations between prostate cancer and serum concentrations of both tocopherols in the men who were receiving the trial alpha-tocopherol supplements."
Gene Mutations Associated with Lung Cancer in Nonsmokers
A new study confirms previous reports that mutations in the EGFR (epidermal growth factor receptor) gene, which are associated with responsiveness to the lung cancer drug gefitinib (Iressa), occur preferentially in four subsets of patients: women, patients who have never smoked, Asians, and patients with adenocarcinoma.
The reason the mutations appear among these groups is not clear, but they can lead to the development of non-small-cell lung cancer, according to research in the March 2 Journal of the National Cancer Institute. In the largest such study to date, researchers profiled more than 600 lung tumors from patients in Japan, Taiwan, the United States, and Australia.
EGFR mutations were more common in females than males (42 percent vs. 14 percent), in never-smokers than in smokers (51 percent vs. 10 percent), in adenocarcinomas than in other types of lung cancer (40 percent vs. 3 percent), and in patients of East Asian ancestry than in other ethnicities (30 percent vs. 8 percent).
EGFR mutations are the first known to occur in nonsmokers with lung cancer, according to Dr. Adi F. Gazdar of the University of Texas Southwestern Medical Center at Dallas, who led the study. "We always believed that lung cancer in nonsmokers was due to exposure to second-hand smoke, but here we're seeing very different changes at the molecular level in nonsmokers and smokers," said Dr. Gazdar. "The implication is that there may well be factors that lead to cancer in nonsmokers other than second-hand smoke."
Intervention for Rural Residents Improves Dietary Behavior
The first physician-endorsed, low-intensity dietary intervention to target a rural, low-income population made up of poorly educated, minority individuals demonstrated the feasibility of effectively changing dietary behavior in rural residents. Results of the NCI-funded Rural Physician Cancer Prevention Project, published in the February American Journal of Preventive Medicine, demonstrate significant improvement in dietary fat and fiber consumption in this population.
Dr. Elizabeth Fries, of Virginia Commonwealth University, and her colleagues enrolled patients from three physician practices in rural Virginia and randomly assigned them to an intervention (tailored feedback on eating habits, brief counseling, and dietary self-help booklets) or control group. Intervention materials were written at or below a sixth-grade reading level and mailed along with letters from participants' physicians. Investigators conducted follow-up phone interviews 1, 6, and 12 months after the intervention. Individuals in the intervention group significantly reduced their dietary fat intake, increased dietary fiber consumption, and expressed an intention to reduce dietary fat and eat more fiber, fruits, and vegetables.
Efforts to improve health in rural areas may be compromised due to reduced access to health care and lack of appropriate nutrition education. The authors note that rural primary care providers may be viewed by community members as the only legitimate source of health information; however, many are overburdened with a large patient load. This study shows that a low-intensity dietary intervention can net significant changes without increasing time constraints on physicians.
The following are newly-released NCI research funding opportunities:
In Utero Exposure to Bioactive Food Components and Mammary Cancer Risk
This funding opportunity will use the NIH investigator-initiated research project grants (R01) and Exploratory/Developmental (R21) award mechanism(s). For more information see http://cri.nci.nih.gov/4abst.cfm?initiativeparfa_id=2620. Inquiries: Dr. Cindy D. Davis - email@example.com.
Continued Development and Maintenance of Software
Correlative Studies with Specimens from Multi-Site Trials
For comprehensive information about NCI funding priorities and opportunities, go to http://www.cancer.gov/researchandfunding.
The NIH Roadmap for Medical Research Funding provides a framework of the priorities NIH must address to optimize its research portfolio. It identifies the most compelling opportunities in three main areas: new pathways to discovery, research teams of the future, and re-engineering the clinical research enterprise. Newly released Roadmap funding opportunities are listed below. For information on additional Roadmap funding opportunities, go to http://nihroadmap.nih.gov.
Comparing Treatment for Women with DCIS
Name of the Trial
Principal Investigators
Why Is This Trial Important?
Recent studies indicate that anastrazole, which belongs to a class of drugs called aromatase inhibitors, is more effective than tamoxifen in preventing breast cancer recurrence in postmenopausal women treated with surgery for invasive breast cancer. In this trial, researchers are investigating whether anastrazole is more effective than tamoxifen in preventing DCIS recurrence and invasive breast cancer development in postmenopausal women treated with lumpectomy and radiation therapy for DCIS.
"Anastrazole has shown significant improvements over tamoxifen in terms of safety and efficacy," said Dr. Margolese. "We believe it has the potential to be an important treatment option for women with DCIS."
Who Can Join This Trial?
Where Is This Trial Taking Place?
Contact Information
An archive of "Featured Clinical Trial" columns is available at http://cancer.gov/clinicaltrials/ft-all-featured-trials.
Los Angeles Science Writers Seminar
The NCI Press Office conducted two special events in Los Angeles last month. On February 23, NCI sponsored its first Science Writers' Seminar outside of the D.C. area, partnering with local Comprehensive Cancer Centers in presenting a seminar on cancer and genetics. Dr. Steve Libutti of the CCR Surgery Branch of NCI and researchers from UCLA's Jonsson Cancer Center, USC/Norris Cancer Center, and City of Hope presented information to reporters from National Public Radio, the L.A. Times, N.Y. Times, Pasadena Star-News, Santa Monica Daily Breeze, and a number of major publications that target Hispanic and Asian populations in the L.A. basin. The archived webcast of the seminar can be viewed at http://videocast.nih.gov/PastEvents.asp?c=4.
On February 24, Dr. Libutti joined staff from the Centers for Disease Control and Prevention (CDC) in visiting head writers and producers from such TV shows as Medical Investigations, ER, and Grey's Anatomy to discuss potential stories related to cancer and how NCI and CDC can assist them in developing factual and informative dramas. That evening Dr. Libutti, along with five other prominent spokespersons, addressed a well-attended symposium at the Writers Guild of America on areas of interest and concern in genetic testing for cancer and other diseases.
Roberts Wins Leopold Griffuel Prize
Dr. Roberts was recognized for her seminal work in the purification, characterization, and further analysis of transforming growth factor-ß (TGF-ß), which she began almost 20 years ago in the NCI laboratory of Dr. Michael Sporn. TGF-ß is a protein with properties and functions common to many growth factors. TGF-ß has emerged as a growth factor with unique signaling paradigms and plays key roles in wound healing, as well as in autoimmune disease, fibrosis, and cancer.
Past winners of the Leopold Griffuel Prize include Drs. C. Everett Koop, Samuel Broder, Steven Rosenberg, Robert Gallo, and Vincent DeVita. The award ceremony will take place in Paris on October 15.
Prostate Cancer Endpoints Discussed at FDA Advisory Meeting
The discussion focused primarily on the utility of endpoints based on prostate-specific antigen (PSA) levels and other indicators such as quality-of-life measures. No clear consensus emerged about endpoints, but part of the discussion focused on a proposal to use a reduction in PSA by 50 to 75 percent over 3 months as the primary indicator of efficacy in a prospective clinical trial for advanced prostate cancer.
Liotta to Leave NCI
How Will New Ethics Guidelines Affect NCI's
Relationships with the Cancer Community?
"As a dynamic research institution, we will continue the tradition of supporting and encouraging collaborative research," commented Dr. Robert Wiltrout, director of NCI's Center for Cancer Research (CCR). "Although there have been new policies relating to conflict-of-interest review, CCR is committed to using all of the available official duty mechanisms to ensure that our researchers maintain their traditional research interactions with industry and academia.
"Our researchers remain ready to fully participate in collaborations through a variety of well-established collaborative mechanisms such as Cooperative Research and Development Agreements (CRADAs), Clinical Trial Agreements (CTAs), and Material Transfer Agreements, while continuing to look for additional mechanisms to facilitate research interactions," Dr. Wiltrout continued. "The new rules and regulations retained most of the existing flexibility in regard to maintaining and engaging in official duty activities outlined in the February 22 NIH Catalyst. CCR will continue to use these mechanisms to ensure future collaborative research successes."
The partnerships NCI pursues as official duty activities are designed to take the comparatively early findings coming out of NCI, help them mature, move forward, and eventually become commercial treatments and products that benefit the public health. As long as an activity is consistent with their official duties, NIH researchers can continue to participate in collaborations with pharmaceutical and biotech companies and academic research centers. With the appropriate clearances, NIH researchers will also be able to maintain memberships on committees and boards of professional associations.
In addition, as part of official duties, NIH researchers will still be able to:
A tighter standard applies to some activities - such as writing or editing a peer-reviewed scientific publication and teaching Continuing Medical Education courses - for which scientists can still be paid to perform in a personal capacity, subject to funding source.
"Clearly these regulations are bringing about some significant changes at NCI and NIH," acknowledged Dr. Wiltrout. "But as far as our researchers' official interactions with others who are affected by what we do here, NCI researchers will continue to be active collaborators and participants."


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Monday, 16 Aug 2010 06:10 PM
By David Limbaugh
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Tuesday, 30 Sep 2014 09:49 AM
We mention President Obama's narcissism not as an exercise in name-calling but because it continues to be relevant to ho . . .
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Republicans and other lovers of the rule of law have little reason for optimism as to the character of Holder's eventual . . .
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It's one thing to insist, for example, that English be the official language; it's one thing to forbid American students . . .
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It would have been easy for the Minden High Crimson Tide to lose Monday night.
After all, the boys were riding an emotional high following a sweep in last week's Holiday Classic. They were tired, drained physically and emotionally. And Airline, their 5A opponent Monday, wasn't a bunch of slouches on the hard court.Subscribe to Read!


text: ArticleRelated DiseasesImages & Quizzes smallermediumlarger 1 2 3 Next Angiotensin II Receptor Blockers (ARBs) High Blood Pressure (Hypertension) Slideshow Take the Salt Quiz! Lowering Blood Pressure Exercise Tips Pictures Pharmacy Author: Omudhome Ogbru, PharmD Omudhome Ogbru, PharmD Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99. View Full Profile Medical and Pharmacy Editor: Jay W. Marks, MD Jay W. Marks, MD Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles. View Full Profile What are angiotensin receptor blockers (ARBs), and how do they work? For what conditions are ARBs used? Are there any differences among the different types of ARBs? What are the side effects of ARBs? With which drugs do ARBs interact? What are the available ARBs? What are angiotensin receptor blockers, and how do they work? Angiotensin II is a very potent chemical that causes muscles surrounding blood vessels to contract, thereby narrowing blood vessels. This narrowing increases the pressure within the vessels and can cause high blood pressure (hypertension). Angiotensin II receptor blockers (ARBs) are medications that block the action of angiotensin II by preventing angiotensin II from binding to angiotensin II receptors on blood vessels. As a result, blood vessels enlarge (dilate) and blood pressure is reduced. Reduced blood pressure makes it easier for the heart to pump blood and can improve heart failure. In addition, the progression of kidney disease due to high blood pressure or diabetes is slowed. ARBs have effects that are similar to angiotensin converting enzyme (ACE) inhibitors, but ACE inhibitors act by preventing the formation of angiotensin II rather than by blocking the binding of angiotensin II to muscles on blood vessels. For what conditions are ARBs used? ARBs are used for controlling high blood pressure, treating heart failure, and preventing kidney failure in people with diabetes or high blood pressure. They may also prevent diabetes and reduce the risk of stroke in patients with high blood pressure and an enlarged heart. ARBs may also prevent the recurrence of atrial fibrillation. Since these medications have effects that are similar to those of ACE inhibitors, they often are used when ACE inhibitors are not tolerated by patients (for example, due to excessive coughing). Are there any differences among the different types of ARBs? ARBs are similar in actions and side effects. They differ in how they are eliminated from the body and the extent to which they are distributed throughout the body. Some ARBs need to be converted to an active form in the body before they can lower blood pressure. In addition, some ARBs are better at lowering blood pressure. In some studies, irbesartan (Avapro) and candesartan (Atacand) reduced blood pressure better than losartan (Cozaar). What are the side effects of ARBs? ARBs are well tolerated by most individuals. The most common side effects are cough, elevated potassium levels in the blood (hyperkalemia), low blood pressure, dizziness, headache, drowsiness, diarrhea, abnormal taste sensation (metallic or salty taste), and rash. Compared to ACE inhibitors, cough occurs less often with ARBs. The most serious, but rare, side effects are kidney failure, liver failure, allergic reactions, a decrease in white blood cells, and swelling of tissues (angioedema). ARBs usually are not prescribed for pregnant patients because they may cause birth defects. Individuals who have narrowing of both kidney arteries or have had a severe reaction to ARBs should avoid them. Like other antihypertensives, ARBs have been associated with sexual dysfunction. Next: With which drugs do ARBs interact?1 2 3 Next Angiotensin II Receptor Blockers Index Report Problems to the Food and Drug Administration You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088. Need help identifying pills and medications?Use the pill identifier tool on RxList. Back to Medications Index Share this Article: Facebook Twitter Email Print Article Suggested Reading on Angiotensin II Receptor Blockers (ARBs) by Our Doctors Related Diseases & Conditions 17 articles Kidney Failure Kidney failure can occur from an acute event or a chronic condition or disease. Prerenal kidney failure is caused by blood loss, dehydration, medication. Diabetes (Type 1 and Type 2) Diabetes mellitus is a chronic condition characterized by high levels of sugar (glucose) in the blood. The two types of diabetes are referred to as type High Blood Pressure High blood pressure is defined as a pressure of 140/90 mmHg or higher in the arteries. Genetic factors, high salt intake, and increased arterial stiffness Congestive Heart Failure (CHF) Congestive heart failure (CHF) refers to a condition in which the heart loses the ability to function properly. Heart disease, high blood pressure, diabetes, Cough Chronic cough is a cough that does not go away and is generally a symptom of another disorder such as asthma, allergic rhinitis, sinus infection, cigarette Angina Angina is chest pain due to inadequate blood supply to the heart. Angina symptoms may include chest tightness, burning, squeezing, and aching. Coronary Atrial Fibrillation Atrial fibrillation is an abnormality in the heart rhythm which involves irregular and often rapid beating of the heart. Symptoms may include palpitations, Abnormal Heart Rhythms (Heart Rhythm Disorders) Heart rhythm disorders vary from minor palpitations, premature atrial contractions (PACs), premature ventricular contractions (PVCs), sinus tachycardia, Stroke A stroke is an interruption of the blood supply to part of the brain caused by either a blood clot (ischemic) or bleeding (hemorrhagic). Symptoms of a Heart Failure Heart failure is caused by many conditions including coronary artery disease, heart attack, cardiomyopathy, and conditions that overwork the heart. Symptoms High Blood Pressure Treatment High blood pressure (hypertension) means high pressure (tension) in the arteries. Treatment for high blood pressure include lifestyle modifications (alcohol, Renal Artery Stenosis Renal artery stenosis is a narrowing of the diameter of the renal arteries. When the renal arteries narrow, the result is restricted blood flow to the Hypertensive Kidney Disease High blood pressure can damage the kidneys and is one of the leading causes of kidney failure (end-stage renal kidney disease). Kidney damage, like hypertension, Diabetes and Kidney Disease In the United States diabetes is the most common cause of kidney failure. High blood pressure and high levels of blood glucose increase the risk that a Cardiomyopathy (Dilated) Dilated Cardiomyopathy is a condition where the heart's ability to pump blood is decreased because the heart's main pumping chamber is enlarged and weakened. Kidney Dysplasia Kidney dysplasia is a condition in which one or both of a baby's kidneys do not develop normally. In kidney dysplasia, cysts replace normal kidney tissue. Cardiomyopathy (Restrictive) Restrictive cardiomyopathy, the rarest form of cardiomyopathy, is a condition in which the walls of the lower chambers of the heart (the ventricles) are Medications 7 articles Procedures & Tests 1 articles Pictures, Images & Quizzes 5 articles Doctor's & Expert's Views 8 articles Health News 5 articles Health Features 3 articles Privacy Policy Hypertension Get tips on handling your hypertension. By clicking submit I agree to WebMD's Privacy Policy


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Those having the passing by reference issue can use this simple hack.
I´m really not sure WHY this works, but it does, and it does not make use of EVAL or other questionable functions.
function executeHook($name, $type='hooks'){
$args = func_get_args();
//Rather stupid Hack for the call_user_func_array();
$Args = array();
foreach($args as $k => &$arg){
$Args[$k] = &$arg;
//End Hack
$hooks = &$this->$type;
if(!isset($hooks[$name])) return false;
$hook = $hooks[$name];
call_user_func_array($hook, $Args);
All it´s doing is copying the args ($args) into a new array ($Args) by reference, which i would think would be identical to the original array in every way (that matters).
Note the code here is an example of usage. The actual hack is denoted by comments.
If someone knows a better alternative, by all means, i would love to see it.


text:
All Over the Map
About All Over the Map
Leslie Kehmeier is a Colorado-based mountain bike nerd. When she's not making maps and creating GPS routes for the International Mountain Bicycling Association, she's on the road searching for good coffee, great food and amazing trails.
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In Memory of Reverend Dr. Ronald Coleman
April 5, 1943- August 29, 2012 You are forever missed Love Linda, Julia, Sabrina, Shawta, & Aleeyah
In Loving Memory Of Reverend Dr. Ronald Coleman
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Leather Dog Leash
A leash built for heavy wear in and out of the field
To order by phone, please call 1-866-860-8906
Our dog lead is made from the same Genuine Bridle Leather as our famous belts. Cut from the strongest part of the hide, this leather will stand up to the worst abuse. Features brass hardware and riveted construction. Lead is 5' long and 1" wide. Made in USA.
- Formerly style #2201
Hunting, Field, Shooting, Casual
Made in USA.
New Filson Dog Products
Thank you, With every fine Filson item I have purchased I have taken the time to fill out the warranty card, including the "items I would like to see" section and both my wife and I were extremely excited to see the latest issue, containing the "Filson Dog" section. I do not think my dogs are the definitive "Filson Dogs," they are not the great hunters that their lineage has produced in the past, but when I take them hunting they stay out of the other dogs ways so are always a welcomed group. I find the luxury and practibilty I enjoy in Filson garments, luggage and gear is something my two labs deserve. You made their Christmas shopping (if I can wait that long) easy.
P.S.: Now just put out the purses for my wife, You put out a line of purses (keep it small please) and at least my wife won't be so quick to ban me from looking at the latest issue due to budget concerns.
Stuart J. McNally


text: The Americas Destinations Country Destinations Etihad Destinations in The Americas Travel through the Americas by booking a flight with Etihad Airways. The Americas offer travel destinations to fit any style: bustling metropolises in New York and São Paulo, windswept mountainsides along the towering Rockies, and the hot, thick wilds of the Amazon Rainforest. Top 5 Things to Do in the Americas New York is known as the Big Apple. With museums like the Metropolitan Museum of Art and MoMA, glittering plazas like Time Square, and the song & dance of Broadway, a trip to New York City will create a lifetime of memories. Fly through 2 billion years of the Earth's history by traveling to the Grand Canyon. Carved by the Colorado River, the Grand Canyon is 18 miles wide and 6,000 feet deep at its widest and deepest points. Book your tickets for the Museu de Arte de São Paulo in Brazil, which boasts Latin America's biggest collection of Western art, including a world-renowned Impressionist collection. The museum itself is considered a classic of modernist architecture. Straddling New York State and the Canadian Province of Ontario, more water flows over the roaring Niagara Falls than at any other waterfall on Earth: a staggering 6,500 cubic meters per second. Travel to the Amazon Rainforest. The largest, most bio-diverse rainforest in the world covers land in Brazil, Peru, Columbia, Venezuela, Ecuador and more, and is territory for a truly adventurous vacation. Plan Your Holiday in the Americas The two continents that make up the Americas span the Globe almost from North to South Pole. Travelers in the Americas can fly from some of the busiest cities to the most desolate wildernesses on the planet. Booking your flight to the Americas with Etihad Airways is a sure way to create a fun-filled, educational and unforgettable trip for the whole family. Country Destinations Brazil Canada United States


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The most famous eyes in MMA.
As the sport of Mixed Martial Arts grew and continued its worldwide domination, Bad Boy was there the entire time. Join the Bad Boy family with the Bad Boy Walk In 2 shirt!
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I would buy this product again and again
By PAYOT
from Glun FRANCE
About Me Career, Classic
Comments about Bad Boy International Walkout Shirt:
For me, it's the best mma shirt !
Bottom Line Yes, I would recommend this to a friend
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By Rico
from Los Angeles
About Me Athletic
Used for Martial Arts and Spinning classes
Great Product!
By Michael
from Sunnyvale, CA
About Me Bargain Shopper
This shirt is great! I love the fit which is perfect for slim-fit people. The color is nice and the material soft. I would definitely recommend it!
Bad boy international walkout shirt
By bob
from Brisbane Australia
Great shirt just as expected washes well well made shirt. Would buy this shirt again.
Very Nice Shirt
By Cyndi
from Albuquerque, NM
About Me Career, Casual, Classic
Conversation starter. UFC is getting very popular.
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Designed to give you the best possible tow sports experience. With the largest engine in the Sea-Doo Tow Sport watercraft lineup, plus our exclusive S3 Hull for added stability when towing wakeskaters and wakeboarders. And there's a host of other tow-sport-specific features. All of them make it easier to say "Yes" each time you get asked, "Can we go again?"
Have a question about the 2014 Sea-Doo Tow Sports Wake Pro 215?


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Changes related to "DTP PMC Meeting from 2009, July through September"
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