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Cancer Stem Cells May Help Brain Tumors Survive Radiation
Some brain tumors may contain small populations of cancer stem cells that are resistant to radiation therapy, and this may help explain why the disease often recurs after treatment, even when there are no detectable signs of cancer.
Researchers at Duke University Medical Center have found that cancer stem cells isolated from brain tumor tissues can survive radiation treatments. Although their DNA is damaged, these cells make repairs more efficiently than other tumor cells. Read more
NCI Director's Swearing-In Remarks
Following are Dr. John E. Niederhuber's remarks made at his public swearing-in ceremony as NCI Director on October 18, 2006.
Mr. Secretary, Dr. Zerhouni, fellow directors of the institutes and centers of the National Institutes of Health [NIH], honored guests, NCI colleagues, and my many friends: I am deeply indebted to all of you for being here today and for sharing with me this very special occasion in my life.
I want to express my gratitude to President Bush and to [Department of Health and Human Services/HHS] Secretary Leavitt for the privilege and distinct honor of serving as the director of the National Cancer Institute. I am profoundly humbled by your confidence in me and by the fact that you are willing to entrust me with the leadership and the distinguished history of this proud institution. Read more
Cancer Stem Cells May Help Brain Tumors Survive Radiation
Some brain tumors may contain small populations of cancer stem cells that are resistant to radiation therapy, and this may help explain why the disease often recurs after treatment, even when there are no detectable signs of cancer.
Researchers at Duke University Medical Center have found that cancer stem cells isolated from brain tumor tissues can survive radiation treatments. Although their DNA is damaged, these cells make repairs more efficiently than other tumor cells.
"We found that cancer stem cells could deal with DNA damage from both chemotherapy and radiation more readily than other cells and survive better," says lead investigator Dr. Jeremy Rich.
His team used a protein called CD133 to distinguish potential cancer stem cells from other cells in glioblastoma tumors, the most common form of brain cancer. The disease resists all treatments, and most patients survive only a year after diagnosis.
The new findings, published early online October 18 in Nature, point to a role for cancer stem cells in glioblastoma, and they add to growing evidence that these rare cells may be the critical targets for treating cancer.
Cancer stem cells were first reported in the brain in 2004. Dr. Peter Dirks of the Hospital for Sick Children in Toronto led a team that isolated brain tumor cells with some of the properties of stem cells. The cells could divide indefinitely, give rise to various types of cells, and form tumors when transplanted into mice.
The definition of a cancer stem cell has been controversial, and the Duke team did experiments to show that they were working with cancer stem cells or cells with similar properties. In one example, when a few hundred of these cells were transplanted into mice, they formed tumors that resembled the original tumors, even after being irradiated.
"This is an exciting study," says Dr. Dirks. "It's important to show that cancer stem cells are resistant to treatment because that will redouble our efforts to consider those cells as the most crucial for cancer therapy."
The study offers insights into the biology of the tumor that could be relevant to treating patients. Knowing that DNA repair was important, the researchers blocked the DNA-repair response in mice as a potential strategy for overcoming resistance.
It seemed to work - radiation treatments killed cancer stem cells in mice when drugs inhibited their "checkpoint" proteins, which regulate DNA repair.
This study provides the first evidence of a potential mechanism - enhanced DNA repair - that allows cancer stem cells in solid tumors to survive and that could be targeted by therapies, says Dr. Craig Jordan of the University of Rochester. His team has developed ways to selectively target leukemia stem cells while sparing normal cells.
"The efficacy with which the researchers could kill these cells with radiation in the presence of a checkpoint inhibitor was striking," notes Dr. Jordan. "This is proof of concept in the brain cancer field that it is possible to target malignant stem cells."
Whether the results will be clinically useful remains to be seen, but they will likely be welcomed by physicians who treat this deadly disease.
"This study is encouraging," says Dr. Paul Fisher of the Stanford Comprehensive Cancer Center. "It improves our understanding of the biology, and this is the only way we are going to move forward in treating glioblastoma."
By Edward R. Winstead
NCI Director's Swearing-In Remarks
Following are Dr. John E. Niederhuber's remarks made at his public swearing-in ceremony as NCI Director on October 18, 2006.
Mr. Secretary, Dr. Zerhouni, fellow directors of the institutes and centers of the National Institutes of Health [NIH], honored guests, NCI colleagues, and my many friends: I am deeply indebted to all of you for being here today and for sharing with me this very special occasion in my life.
I want to express my gratitude to President Bush and to [Department of Health and Human Services/HHS] Secretary Leavitt for the privilege and distinct honor of serving as the director of the National Cancer Institute. I am profoundly humbled by your confidence in me and by the fact that you are willing to entrust me with the leadership and the distinguished history of this proud institution.
Never, in all the years of sitting on the edge of my patients' beds during late-evening rounds; of making the walk from the operating room to the family waiting area; of working in the lab with my students and fellows (some of whom are here today); of coming to Washington all those times to serve on committees for Vince, Sam, Rick, and, most recently, Andy - never did I picture myself standing at this podium at this time to accept the directorship of the National Cancer Institute.
And while I have been doing this job now for a year, I think it has only been in the past couple of weeks, since my official appointment, that the enormity of the responsibility of this position - the responsibility to our patients suffering with cancer - has really struck home.
On the day he formally proposed the National Cancer Act of 1971, President Nixon said, "The time has now come for us to put our money where our hopes are." But he also made it eminently clear that dollars weren't enough. "Money," Mr. Nixon continued, "can help set the stage for faster progress, but in the end it is our brainpower alone which can lead us to our goals."
President Nixon's words are even more fitting today. The momentum of our progress against cancer, and of biomedical research as a whole for all diseases, is occurring at a pace none of us could have predicted. For the very first time in more than 70 years that our country has kept statistics on cancer incidence and mortality, we have seen an actual, real decline in cancer deaths.
For every one of us here today, that is the hope - the promise - we have so desperately needed. This progress, this pace of discovery, and our nation's leadership position in biomedical research must not be taken for granted.
Today, even more so than in 1971, we face very real challenges, which test our ability to persuade the very brightest, the most visionary of our young people, to see the opportunities and the rewards of a career in biomedical research and patient care.
Our success - the ability to achieve our goals - depends on college students who see and who value the tremendous opportunities of a life immersed in scientific discovery: a life of service, of caring for those less fortunate. These young citizens need to have confidence that this great country will continue its investment in science. They need to be confident that productive careers await them.
NIH has long been the mechanism through which this great nation supports the world's premier biomedical research engine. Through its outstanding intramural laboratories and the support of an unmatched cadre of extramural scientists, we have been blessed with success after success.
There is no other NIH. There is no other place like NCI anywhere in the world. It is imperative that we tell our story, and that we work with the leaders of our country to ensure that the United States continues to lead the world, that we continue to serve the world.
Elias, my friend, I could not be more proud, nor can I think of any greater honor, than to be asked to join my colleagues on the NIH team. To my fellow institute and center directors, I extend a hand of friendship, of collegiality, and - perhaps most important - of collaboration.
While we at NCI are dedicated to lessening the burden of cancer, we also recognize that cancer has been, and will continue to be, a research model for many diseases. An article in the Journal of the National Cancer Institute provides a timely reminder of our importance as a community of scientists. "Progress," the author wrote, "has been most rapid in scientific research when imaginative, talented, technically curious, and, above all, sincerely interested investigators are encouraged to search for new facts, beyond the curtains that limit our knowledge and to pool their specialized resources and skills on a basis of mutual interest and respect."
That's a message we can - and do - embrace. But it is even more profound when you consider that the quote I just read comes from an article written nearly half a century ago, in 1957, by G. Burroughs Mider, NCI's associate director in charge of research. His words remind us that the need for scientific collaboration across disciplines is not a new idea.
It is my great hope that through my leadership at NCI and through the talented NCI scientific community, we can continue, and even fortify, the tradition Dr. Mider so eloquently described.
To the staff of NCI: I am honored and proud to work in your service. Institutions - university or government, private or public - that do great work and make a true difference in this world are always infused with people of enormous talent, commitment, and drive.
The importance of what we do at NCI - on behalf of every man, woman, or child who knows or fears cancer - cannot be underestimated. And, as a cancer research community, we are certainly not exempt from the disease we dedicate our careers to fight. Indeed, for a great many of our colleagues at NCI, cancer is a personal, as well as a professional, issue, because they - or perhaps I should say we - are survivors, patients, caregivers, or loved ones of cancer patients.
Sometimes, in the course of our lives, we talk about being in the right place at the right time. Sometimes we may speak of destiny or fate or direction. However we choose to interpret them, I believe that these important crossroads in life are about recognizing and grasping opportunities, and making all you can of them.
As I said earlier, the rapidity with which we are gaining new knowledge, coupled with the emergence of constantly advancing technologies, is creating greater opportunity to accelerate progress against cancer than any of us dared to dream at the time I began my career. Cancer, we know today, is a disease of alterations in genes, which accumulate over a lifetime. Each day, it seems, our insights grow deeper. We come to a greater understanding of the genetic changes that render a cell malignant. We learn more about the complex interactions of the cancer cell with its microenvironment and host. We learn more about the drivers of metastasis.
In today's post-genomic scientific environment, we are rapidly entering an entirely new era of risk determination, disease prevention, diagnosis, and highly targeted therapies. It is the era of genomically and proteomically characterized disease. As we move into this new era of personalized medicine, ideas, tactics, and techniques are coming from many sectors of science. The physical sciences and engineering are being applied to optimize the discovery, development, and, ultimately, the delivery of interventions to the patient. The once-futuristic tool of nanotechnology is being used to perform molecular classification of tumors to enable high-throughput screening and to predict therapeutic efficacy. Imaging is becoming a tool to ascertain just how much of a small molecule is reaching a targeted receptor and whether the therapeutic molecule changes cellular function. Computational biology - systems biology, if you will - is addressing issues such as information scale, modeling, simulations, and data interpretation.
For certain, new technologies will continue to blossom and multiply.
I know that our time together at NCI will hold moments of great success. I look forward to every exciting advance and discovery.
I also know our time together will bring many challenges. We are in a fiscal period in which management of NCI will involve the careful stewardship of finite resources.
I will do my best to provide you with an open door and a listening ear, with strong leadership skills honed in the operating room and the laboratory, to captain this team in difficult times. It will be up to the leaders of NCI to find and allocate the resources necessary to maintain our scientific momentum.
To this end, NCI will need to consider new partnerships in order to leverage resources and knowledge. We will need to carefully consider each new research program and scientific proposal. We will need to examine all existing programs, to search for ways to be leaner, but at the same time even better, in achieving our mission. Our responsibility is to continue conducting quality research, offering solutions to our challenges. As Albert Einstein said, "In the middle of every difficulty lies opportunity."
It is critical in these times that we communicate effectively across our various constituencies. As a cancer community, we must strive to speak with a more unified voice in order to call others to action on behalf of cancer research.
I believe we must work to find the best ways to bring the latest science to patients in the communities where they live - through our NCI-supported cancer centers, which are always referred to as the "crown jewels" of NCI - and by the building of a new rim of community-based cancer care.
We must make our science, our medical advances, available to all of our citizens, especially those who may lack the financial means, the language capacity, the education, or simply the physical strength to seek out the best care. We must bring our science - our technology - to the patients where they live.
I share the view of my friend and colleague John Seffrin, chief executive officer of the American Cancer Society, who so effectively states his belief that, in the next decade, patient access to our accomplishments - our science - will become a greater determinant of cancer mortality than any currently recognized cause.
In one of the most-quoted lines of American politics, the late Vice President Hubert Humphrey said the moral test of government is how it treats "those who are in the dawn of life, the children; those who are in the twilight of life, the elderly; and those who are in the shadows of life, the sick, the needy, and the handicapped."
It is, after all, our responsibility to continually earn, and always merit, the public's trust. We maintain that bond by being good financial stewards, by letting the best science be our guide, by clearly and plainly communicating what we learn about cancer, and by honestly saying what we have yet to learn. We should convey hope, but always be grounded in facts.
And so it is with an unshakable commitment - to every cancer patient, every survivor, advocate, friend, father, mother, son, daughter, and caregiver - that I sincerely thank you for the opportunity to serve this great institution and this great country, and solemnly pledge to do my very best. May God bless America, and give us the knowledge and wisdom to serve our patients.
Data on Genetic Susceptibility for Prostate Cancer Are Released
NCI recently released data from the Cancer Genetic Markers of Susceptibility (CGEMS) prostate cancer study, which could help identify genetic factors that influence the disease and affect development of new therapies.
"The immediate sharing of the database with the cancer research community will allow researchers to compare existing and developing information with CGEMS data to identify new genes associated with increased prostate cancer risk," said NCI Deputy Director for Advanced Technologies and Strategic Partnerships, Dr. Anna D. Barker.
CGEMS procured genetic samples of prostate cancer from more than 1,100 men with the disease and 1,100 men without it. The samples included over 680 million individual genotypes and 310,000 genetic variants. Finding genetic variations that differ in frequency between patient and control groups will help identify the location of multiple inherited genes that affect the risk of prostate cancer.
"CGEMS represents one of the first of a new generation of studies made possible by the Human Genome Project," added Dr. Gilles Thomas of NCI's Division of Cancer Epidemiology and Genetics and lead scientist of the project. "Through immediate data sharing, we hope to encourage other teams to make similar studies in cancer and other diseases rapidly accessible to speed progress in understanding the inherited causes of cancer."
Launched in February 2006, CGEMS is the largest comprehensive initiative to identify genetic risk factors for breast and prostate cancers, two of the most frequently diagnosed cancers in the United States. Similar data on breast cancer are now being generated and anticipated for release in early 2007.
CGEMS study data are available through NCI's cancer Biomedical Informatics Grid™) at http://caIntegrator.nci.nih.gov/cgems/.
Recommended Colorectal Cancer Surgery May Be Underused
A new population-based study suggests that multivisceral resection - a surgical procedure recommended for patients with colorectal cancer that has not metastasized but that has affected organs adjacent to the colon or rectum - is drastically underused. Failure to use the procedure was associated with poorer overall survival rates, the study found.
Published in the October 18 Journal of the National Cancer Institute (JNCI), the study used NCI's Surveillance, Epidemiology, and End Results (SEER) registry to review the care and outcomes of 8,400 patients who underwent surgery to remove colon or rectal tumors that had expanded into nearby organs. The study authors, led by Dr. Calvin H. L. Law of Toronto Sunnybrook Regional Cancer Center in Canada, noted that clinical guidelines recommend that such patients undergo multivisceral resection, which involves the removal of the tumor and the adjacent organs.
They found, however, that only one-third of patients included in the study - all of whom were treated between January 1998 and December 2002 - underwent multivisceral resection. The remaining patients had only the tumor removed, which the authors noted is a far less complicated procedure with fewer related morbidities. Patients who underwent multivisceral resection, however, had significantly greater 5-year survival rates (35.1 percent vs. 27.7 percent), and treatment with a multivisceral resection was independently associated with improved overall survival.
Several factors were associated with a greater likelihood of receiving multivisceral resection, the authors found, including being under age 80 and being female. There was also a significant variation in the likelihood of receiving the procedure based on the region of the country in which patients were treated.
Additional studies are needed, they concluded, "to elucidate factors related to the structures and processes of care that contribute to deficiencies in surgical care and to determine future interventions to improve the quality of care delivered to this patient population."
Viral Protein Promotes Kaposi's Sarcoma Lesion Formation
Researchers at the University of North Carolina (UNC) at Chapel Hill have discovered that Kaposi's sarcoma-associated herpesvirus (KSHV) may promote the development of malignant lesions in Kaposi's sarcoma (KS) patients by extending the lifespan of virally infected endothelial cells.
In KS lesions, expression levels of a KSHV protein, K1, vary widely. In order to determine the contribution of K1 to KS tumor progression, the investigators expressed K1 in primary human umbilical vein endothelial cells. They found that the K1-expressing cells survived for more than 200 days in culture, whereas cells expressing a control protein stopped dividing after about 130 days.
Lengthier endothelial cell survival was attributed to a fourfold increase in the secretion of vascular endothelial growth factor (VEGF) following K1-induced activation of gene transcription. VEGF stimulates proliferation of infected endothelial cells, as well as healthy neighboring cells, and fuels the growth of new blood vessels.
Two cell-signaling pathways, VEGF/VEGFR-2 and PI3K/Akt, which enhance cell survival by promoting growth and inhibiting apoptosis, were also highly activated in K1-expressing endothelial cells. In mouse models, the researchers observed that K1 enhances epithelial tumor vasculature and size.
Protein expression changes that affect cell growth control or the ability of cells to invade deeper tissues, such as those provoked by K1, can lead to the development of cancer.
"Understanding how K1 functions may help us understand the pathogenesis of KSHV-associated malignancies and how KSHV functions as a tumor virus in the human population," noted Dr. Blossom Damania, who presented the findings October 16 at the NCI-sponsored 10th International Conference on Malignancies in AIDS and Other Acquired Immunodeficiencies, held in Bethesda, Md.
Radiotherapy Threatens Babies Born to Childhood Cancer Survivors
Radiation exposure has been linked with the occurrence of some childhood cancers, and radiotherapy treatments for children with certain cancers may also cause a second primary malignancy. New findings published in the October 18 JNCI suggest that women who were exposed to radiotherapy during treatment for childhood cancer - especially pelvic radiation - are more likely to deliver infants who are born prematurely (defined as less than 37 weeks gestation) and who have a low birthweight (less than 5.5 pounds).
The data resulted from a new analysis of the ongoing, long-term Childhood Cancer Survivors Study, an NCI-funded longitudinal cohort study of some 20,000 survivors of childhood cancer, with more than 4,000 of their siblings used as controls. Dr. Lisa B. Signorello of the International Epidemiology Institute of Rockville, Md., and colleagues looked at the live children born to 1,264 survivors and 601 controls between 1972 and 2002.
When the cumulative radiation their mothers had received exceeded 500 centigrays (cGY), babies were 3.5 times more likely to be born preterm than were babies born to women who received no radiation. Irrespective of treatment, survivors' risk of giving birth preterm was 21 percent, 1.9 times that for controls. Kidney cancer was the original disease most likely to be associated with preterm birth. There was little or no risk associated with chemotherapy.
While conceding that "the etiology of preterm birth is largely unknown...[and] the mechanism is likely multifactorial," the authors concluded that "the adverse association between uterine irradiation and the risk of future preterm birth might be especially important for girls who receive such treatment before menarche."
In an accompanying editorial, Dr. Leslie R. Schover of the University of Texas M.D. Anderson Cancer Center added that "we should design professional education materials that map out the paths to making informed decisions."
FDA Approves Vorinostat for Cutaneous T-Cell Lymphoma
The Food and Drug Administration (FDA) has approved vorinostat (Zolinza) capsules for the treatment of cutaneous T-cell lymphoma (CTCL), a type of non-Hodgkin's lymphoma. The disease is a cancer of T cells, which are part of the lymph system. In CTCL, which affects an estimated 20,000 Americans each year, malignant T cells migrate to the skin and may be deposited there.
Vorinostat was approved for patients who have tried and failed other therapies. The drug is to be used when the disease persists, gets worse, or recurs during or after treatment with other medicines, according to the FDA.
Approval was based on two clinical trials involving 107 CTCL patients who received vorinostat after their disease had recurred following treatment. About 30 percent of patients responded to the drug, defined by measurable improvement in skin lesions; the response lasted 168 days on average.
Vorinostat is manufactured by Pantheon, Inc., of Mississauga, Ontario, for Merck.
Translational Breast Cancer Research Gets Personal
In recent decades, revolutionary advances in our knowledge of the molecular and cellular biology of cancer have emerged from the laboratory. The resulting challenge has been how to turn these advances in knowledge into advances in the clinic as rapidly and practically as possible.
The idea of using translational research teams - multidisciplinary groups of investigators who work together to move an idea from "bench to bedside" - to achieve this goal has been gaining momentum. In 1992, NCI funded the first eight Specialized Programs of Research Excellence (SPOREs) translational research grants awarded to institutions and designed to promote such interactions between basic, clinical, and applied scientists. Since then, the program has expanded to include 59 grants focusing on 14 cancer types.
The success of this program is evident in the output, explained Dr. Jorge Gomez, chief of NCI's Organ Systems Branch, which oversees the SPORE grants. "Back in 1998, there were maybe 15 to 17 clinical trials in the SPORE program. As of 2005, we had 255 clinical studies, all based on molecular pathways of cancer. The SPORE program has created an environment that is very conducive to translational research, whether the clinical application is in the area of detection, diagnosis, treatment, or prevention."
One area of research that has proven particularly amenable to the translational approach is applying the knowledge of differential gene expression within a specific cancer type to customize treatment for different patients, with the ultimate goal of "personalized medicine" - treatment selected to match the unique molecular characteristics of each patient's tumor.
In a promising recent example in this field, work from the breast cancer SPORE at UNC-Chapel Hill has shown that several experimental gene-expression-based predictors for breast cancer outcome show strong concordance in their predictions, even though there was little overlap in the gene sets used to create the different predictive models.
The UNC SPORE paper, published in the August 10 New England Journal of Medicine, provides an important step in validating these models for future clinical use, explained Dr. Charles M. Perou, assistant professor of Genetics and Pathology at UNC. "There are a dizzying number of prognostic and predictive profiles for breast cancer," said Dr. Perou. "We kept saying to ourselves, 'They can't all be saying different things,' and they're not. They do tend to point to the same results."
Two of the models used in the North Carolina study are currently being tested in large-scale clinical trials: the European Organization for Research and Treatment of Cancer's Microarray in Node-Negative Disease May Avoid Chemotherapy (MINDACT) trial and the Eastern Cooperative Oncology Group's Trial Assigning Individualized Options for Treatment (TAILORx) study. These trials will test if these predictive models can be used prospectively to determine which women will benefit from adjuvant chemotherapy and which can be spared unnecessary treatment.
The SPORE investigators examined a total of five well-known gene-expression-based models, all based on different sets of genes and developed in different laboratories. The 5 models were each tested in tissue samples taken from 295 women with breast cancer and known relapse-free and overall survival times.
Patients were classified using each model, and the assignments of good or bad prognosis, or low or high recurrence probability were compared. The investigators also performed analyses that included the models and variables currently used to make treatment decisions in the clinic, such as estrogen-receptor status, tumor grade, and whether or not tumor cells had spread to the lymph nodes.
For all 295 patients, 4 out of 5 models "were significant predictors of relapse-free survival and overall survival," and "added new and important prognostic information beyond that provided by the standard clinical predictors," stated the authors, led by Cheng Fan and Dr. Daniel Oh of UNC. In addition, they explained, three of the models - including those being tested in the MINDACT and TAILORx trials - were more predictive of outcome than traditional pathological data, such as tumor size and grade.
A greater understanding of the molecular subtypes of breast cancer may lead not only to more targeted use of available treatments, explained Dr. Perou, but also to the development of new therapies specifically aimed at certain subtypes.
"I think one of the exciting things about identifying these subtypes is that it's not just prognostic information," said Dr. Perou. "Going along with the subtypes are all these potential therapeutic targets, present in some tumors and absent in others. We know the importance of [the] ER and HER2 [proteins], but there are others embedded in our profiles."
The investigators are further using their translational research relationships and have initiated an inter-SPORE clinical trial to test a targeted therapy against the protein HER1, which was found to be overexpressed in the basal-like breast cancer subtype.
Greenwald Promoted Within PHS
Looking Ahead: NCI's Plan and Budget for FY 2008
NCI is mandated by legislation to prepare and submit an annual budget estimate directly to the President for review and transmittal to Congress. The actual FY 2008 budget will be determined by Congress during the spring and fall of 2007.
This document can be found at http://plan.cancer.gov. Hard copies can be ordered via e-mail at email@example.com, phone at 1-800-4-CANCER, fax at 301-339-7968, or online at www.cancer.gov.
Deadline for Comments on Translational Research
TRWG is currently seeking public input to improve translational research at NCI and is welcoming comments on the proposed initiatives and their associated implementation concepts. This input will be considered as TRWG develops final recommendations, which will be offered to the National Cancer Advisory Board in early 2007.
To comment, visit http://www.cancer.gov/trwg. The deadline for feedback is November 3.
Two More TCGA Pilot Project Components Are Announced
Awards have been made to seven institutions in five states to establish Cancer Genome Characterization Centers (CGCCs). CGCCs will work as a network, with each center using advanced genome analysis technologies to identify major changes in the genomes of the cancers chosen for the TCGA Pilot Project. NCI awarded a total of $11.7 million per year to support the CGCCs.
Additionally, a Data Coordinating Center (DCC) for the TCGA Pilot Project will be developed. The DCC will track data produced by components of TCGA and make TCGA data publicly accessible through databases supported by NCI's caBIG™ and the National Library of Medicine's National Center for Biotechnology Information.
Scientists to Compete for 2007 NIH Director's Pioneer Awards
"We hope this opportunity stimulates even more investigators to send us their boldest, most imaginative concepts," said NIH Director Dr. Elias A. Zerhouni.
Scientists from all career levels and research disciplines may apply for the Pioneer Award with the provision that they are interested in exploring biomedical issues. The application period is December 1, 2006, to January 16, 2007.
More information on the Pioneer Awards, including application instructions, can be found at http://nihroadmap.nih.gov/pioneer.
Following are newly released NCI research funding opportunities:
NCI Limited Competition Supplements for Pilot Projects for Community Networks Program to Reduce Cancer Health Disparities
This is a renewal of RFA-CA-06-504 and will use the U01 award mechanism. For more information, see http://cri.nci.nih.gov/4abst.cfm?initiativeparfa_id=3544. Inquiries: Dr. Kenneth Chu - firstname.lastname@example.com
Advanced Technology Radiation Therapy Clinical Trials Support (ATC)
This is a renewal of RFA-CA-02-505. This funding opportunity will use the U24 award mechanism. For more information, see http://cri.nci.nih.gov/4abst.cfm?initiativeparfa_id=3548. Inquiries: Dr. James A. Deye - email@example.com
2007 NIH Director's Pioneer Award Program
This is a renewal of RFA-RM-06-005 and will use the DP1 award mechanism. For more information, see http://cri.nci.nih.gov/4abst.cfm?initiativeparfa_id=3545. Inquiries: Dr. Judith H. Greenberg - firstname.lastname@example.com
Biobehavioral Methods to Improve Outcomes Research
This is a renewal of PA-05-142. This funding opportunity will use the R21 award mechanism. For more information, see http://cri.nci.nih.gov/4abst.cfm?initiativeparfa_id=3546. Inquiries: Dr. Paige A.
Symptom Clusters in Cancer and Immune Disorders
This is a renewal of PA-05-004. This funding opportunity will use the R21 award mechanism. For more information, see http://cri.nci.nih.gov/4abst.cfm?initiativeparfa_id=3547. Inquiries: Dr. Ann O'Mara - firstname.lastname@example.com


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Big Muddy Monster Brewfest
The Big Muddy Monster Brewfest at Riverside Park in Murphysboro, is a Craft beer lovers dream. Taste from over 25 craft breweries, there's a sanctioned home brew contest, live music, local food & much much more! Come join us for excellent craft brews, live music, and great food.
CITY: Murphysboro
Civil War Weekend
The Shawnee Hills Art Council of Anna Arts Center and P.A.S.T. of Union County are co-sponsoring a Civil War Weekend in Anna, IL. A quick snapshot of the planned events include: Historical bus tour: "Lincoln's Footsteps and Friends in Anna-Jonesboro"; exhibits which include guns and quilts; re-enactors and encampment; storytelling; and Civil War era food and music. So mark your calendars and plan on coming to Anna Arts Center for a journey back in time.
CITY: Anna
Great Carbondale Pumpkin Race
The Great Carbondale Pumpkin Race is a simple concept---take a carved pumpkin, decorate it and insert two independent axles through it and attach wheels, then race your pumpkin down a hill to victory! This event is great family fun and a safe, enjoyable way to celebrate fall. Plus, if you craft a winning pumpkin you get to advance to the championship where you can win prizes!
CITY: Carbondale
Great Carbondale Pumpkin Race
Folks from all over literally take pumpkins and creatively engineer them into race cars. Participants race their pumpkins down the streets of downtown Carbondale, competing with one another, and hope theirs crosses the finish line first! Pumpkins race in a series of categories (largest, fastest, most creative, etc.), and must travel unassisted on wheels inserted onto axles that penetrate completely through the melon (no caster wheels and no support frame or chassis will be allowed). This family-friendly competition is both challenging and fun.
CITY: Carbondale
HalloWine at StarView Vineyards
Live music by local artist Eli Tellor, wine tasting, nacho & chili bar & other goodies. Come dressed to impress in your best costume for a chance to win prizes. We'll be judging individual, couple & group costumes. Pets & children are invited too!
CITY: Cobden
HerrinFesta Italiana
"Ciao" on delicious Italian food and delight in a grand parade. There will be midway rides and games, live music, a bocce tournament, a grape stomp, a pasta cook-off, a kids pet and bike parade, a road race and an art contest.
CITY: Herrin
John A. Logan College Autumn Fest
This annual event features over 100 original, handmade arts and crafts, great food, free admission, and free parking. For more information call 1-800-851-4720, extension 8287.
CITY: Carterville
SIU Saluki Football
Cheer on the SIU Saluki Football team at the state-of-the-art Saluki Stadium. Tailgate before the game with thousands of fans and see why everyone is proud to be a Saluki!
CITY: Carbondale
Veterans Day Parade
Parade begins at 2pm from the Anna City Park entrance on Davie St. and follows Main St. to Jefferson St. and back to the park. The Anna VFW post invites everyone back to the lodge for hot dogs and chili.
CITY: Anna
Vulture Fest
Visit downtown Makanda, Gateway to Giant City State Park, where black vultures and turkey vultures fly and swoop in the skies each fall. This event is a celebration or the vulture's annual migration with live music and displays by local artists for purchase.
CITY: Makanda
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The state's General Assembly will tackle several important matters when it convenes later this week for the new session, including a slew of gun control proposals filed in the wake of the Newtown shootings and a $1.2 billion budget deficit projected for July 1.
While Gov. Dannel P. Malloy has empowered a new study commission to make recommendations on what the state should do following the Dec. 14 shootings at Sandy Hook Elementary School in Newtown, several legislators have also filed their own porposals on gun control ahead of the start of the new session.
Some of the proposals include a bill that would make public the names and addresses of anyone in the state who owns a gun and another that would limit access to ammunition, including high-capacity gun magazines. Malloy's commission is expected to file recommendations in mid-March.
Connecticut's pro-gun lobby has already begun gearing up for what is expected to be a major fight in Hartford this winter and spring over gun control measures.
Besides the debate on guns, the legislature must balance the state budget, which some are projecting will see a $1.2 billion deficit by the start of the new fiscal year on July 1. In addition, state lawmakers must pass a new two-year budget this year.


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Classes are taught by experienced yoga instructors who also share the passion of climbing. This allows them to focus on strengthening and stretching core muscles used in the sport. Yoga practice will help you increase flexibility, strength and mental focus; all vital elements to improve your climbing abilities! Monday - Thursday 7:30-8:30pm


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Visitation began Saturday for Brian Woehlke, the 29-year-old Wayne-Westland
firefighter killed while battling a blaze at a Westland strip
mall. He died from smoke inhalation. His body was found in a burned out section of the building where the roof collapsed.
Click on the video player to watch Ryan Ermanni's report.
Visitation continues Sunday at the Harry J. Will Funeral Home,
34567 Michigan Ave. in Wayne. A funeral mass will take place at 11 a.m.
Monday at Divine Child Catholic Church, 1055 N. Silvery Lane in
Dearborn. A formal firefighter procession to St.
Hedwigs Cemetery, 23755 Military in Dearborn Heights will follow.
Contributions to the Brian Woehlke Charity can be mailed
to the Westland Fire Fighters Charity, P.O. Box 851320, Westland, MI
48185 or delivered to any of the five Wayne-Westland fire stations.
For information, call Kevin Tomaszewski at (313) 505-8130, Fire Station #1 at (734)721-2001 or visit www.local1279.org
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People who suffer from panic disorder often do not feel like going out and hanging with people. In some cases, they just lay in bed and sit in front of TV. Social contacts are often harmed and the person finds difficult to leave the home. But the key for solving problems with panic lays in hanging with people and physical activity. If you do not know how to deal with panic attacks, try to be more physically active and talk with people about your problems sometimes.
You are probably scared to tell them, but if you have at least one friend you can talk to, then you are a happy person and you should use the chance to talk about your panic disorder. Also, if you have a friend who is willing to help you, invite that person to keep you company while you are exercising. It does not have to be serious sport, but some physical activity that will keep your circulation flow. You can go for jogging or trekking. Even gardening can do you good, so consider growing tomatoes in your backyard if you can. In addition, you can get yourself a bike and go for a ride sometimes.
Types Of Exercises When Treating Panic Disorder
Panic attacks may make a person to feel fatigue, but the truth is that being physically active will do that person more good than just laying in bed all the time. If you are coping with panic disorder and would like to know how to deal with panic attacks, follow these steps. Every day try to walk. Even when the panic attack occurs, try to walk slowly. Find a nice place near your home where you can walk like park or a forest. It would be good to find a friend who will walk with you.
Remember this is all mental. There are programs like Panic Away that were created to help panic attacks, which tackle the source of these issues. Putting these ideas to work have shown to be effective.
Meanwhile, walking is good for your anxiety. When you are moving your muscles, your body is producing endorphins; hormones that will make you feel happier. Also, sun and fresh air will affect your body positively and start the natural healing process. Maybe it seems to you that it is better for you to stay inside, but even if it is raining, you should spend some time outdoor every day because nature will help you in curing your condition. The good weather will make you feel better.


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Supply Chain Management Of Temperature-Sensitive Products At Novartis: Advice From An Expert
Gone are the days when pharma can depend on blockbuster drugs to carry them to financial heights; instead, successful pharmaceutical companies are taking a different approach and looking to demand to determine their next step in drug development and supply chain management. For Novartis' Michael Trocchia, this demand has resulted in a new role as the Global Supply Chain Lead for Cell Therapy Products. In this article, he discusses the challenges associated with managing the supply chain for a temperature-sensitive product and what best practices he applies in order to contribute to Novartis' ability to maintain a top spot in big pharma.
- An Exciting Change On The Horizon
- Meet The Board: Pfizer's Dr. Firelli Alonso-Caplen Discusses Outsourcing Challenges And The Future Of Single Use
- FDA's First Draft Guidance Under DSCSA – What It Tells Us And What It Doesn't
- FDA Approval Pushes Novartis Into 21st Century Vaccine Development
A Witness To The History of Outsourcing
Joe Guiles seems too young and mild-mannered to have been at the outbreak of a revolution that began many years ago. But he witnessed firsthand the inception of what would become the complete penetrability of outsourcing throughout the drug industry.
- Big Pharma Veteran, Peter Bigelow, Will Help "Tell It Like It Is" At Outsourced Pharma West
- When To Invest In Protein Production: The Risk-Reward Calculation
- Why We Took A Different Approach To Planning A Conference
- Are You Properly Selecting Your CMO Partners?
How To Reduce The Complexity And Mitigate Risk In Qualifying Active Temperature Controlled Systems
Every shipment of life science products is precious cargo, not only to the shipper, but to the patient at the end of the chain. That transportation process must be strictly qualified to ensure that the product is not lost to damage or spoilage.
Facilitating Production Of Cell Banks Using An Automated Cryovial Dispenser
The rapid aseptic preparation of cryovials is vital for the generation of high quality cell banks. By Stephen Guy, Dave Thomas, and Miriam Foster
Future of the Cold Chain Industry Survey Results
Previewing the results of Sonoco Thermosafe's Future of the Cold Chain Industry survey, which will be fully released at the 12th Annual Cold Chain Global Forum in Boston, September 29-October 3.
Continuous Biomanufacturing: 10 Reasons Sponsors Hesitate
By William Whitford, Sr. Manager, HyClone Cell Culture, GE Healthcare
The industry is abuzz with talk about continuous biomanufacturing (CB), and it virtues have been well described. Here we will look at some of the barriers or concerns perceived to limit its value to the industry. Justified or not, quite a few concerns have been expressed regarding the implementation of this new, rather disruptive technology.
Live Cell Hypoxia Determination In A 3D Spheroid Model
Cell-based assays provide a wealth of drug screening information compared to their biochemical counterparts, and at a fraction of the cost and time seen with traditional animal models.
ONO Pharmaceutical Strives For Global Sales
Gyo Sagara, president, representative director and CEO, challenges his company to enter the cancer field and gain big-pharma relevance.
QCanywhere™ Cloud-Based Quality Control
QCanywhere™ is a revolutionary new cloud-based bundle of quality control applications (QCapps™) that are simple to deploy on any PC or Mac without the need to purchase any hardware.
New Brunswick™ BioFlo® 415, Sterilizable-In-Place, Benchtop Fermentor
The New Brunswick BioFlo 415 sterilizable-in-place fermentor, with advanced touchscreen interface, provides an unprecedented level of convenience and control for research through production applications.
Bio-STAR Technology: Clinical Trial Logistics Management
World Courier pioneered the development of an advanced technology to streamline the management of clinical trial logistics. Unparalleled within the industry, World Courier's cutting edge technological innovations provide you with logistical tools to effectively manage your study – from the pre-trial phase right through to your last shipment.
Aseptic Filling Technologies
ASI's Aseptic Single-Use Filling System is easy to integrate and will quickly streamline your filling process—saving you time and money.
From Premium Logistics To A True Partner In Global Life Science Supply Chain Management
Part one of Marken CEO Wes Wheeler's ten part blog series about the changing face of Life Science Logistics in today's fast-paced pharmaceutical industry. By Wesley Wheeler, CEO, Marken
Temperature Monitoring Technology for Healthcare Shipments
Logistics expert Kevin O'Donnell, Senior Partner, Exelsius Cold Chain Management, presents the basics of temperature monitoring for healthcare shipments. From simple temperature indicators to more sophisticated electronic systems that include intervention protocols, you have more options than you may think. Kevin Etter, Product Manager, UPS Global Healthcare Logistics Strategy Group, explains why it's so important to know what's going on during high value shipments.
How To Assess Total Logistics Cost
Watch this new video to learn new ways to calculate total logistics costs. Susan Li of the Healthcare Strategy Group at UPS reveals the true costs of packaging and shipping.
Biobanking And The Future Of Translational Medicine: Dr Gyorgy Marko-Varga Interview 2 Of 3 Dr Gyorgy Marko-Varga highlights how biobanking will be critical to realize the promise of Translational Medicine and what challenges we need to overcome quality hurdles going forward.
That's Nice LLC
That's Nice is a full-service agency providing research-driven brand management and marketing that enable businesses to achieve their goals. Our integrated services reflect 18 years of knowledge in life science and materials science markets, a passion for strategic thinking, and a comprehensive approach that meets the needs of global companies.
Grace is a global provider of process manufacturing solutions supporting pharmaceutical and biotech industries. Our range of solutions includes peptide building blocks for API synthesis, chromatographic media and packing equipment for process purification, and multifunctional silica excipients for pharmaceutical formulation.
GE Healthcare Life Sciences
GE Healthcare Life Sciences provides the expertise and tools spanning a wide range of applications from basic research of proteins and cells to large-scale purification of biopharmaceuticals.
Welcome to BioProcess Online, the premier Internet source of useful and timely information for the worldwide BioProcess and life sciences industries. This site is designed to serve the needs of laboratory directors, laboratory managers, researchers, scientists, university faculty members, business executives, and other industry professionals. BioProcess Online provides daily news updates and in-depth feature stories about drug discovery, research and development advancements, university-industry collaborations, and regulatory issues.
On this site, industry professionals will find information about new products and technology, bioanalytics, bioreactors, biopurification, bioproduction products, bioprocess sensors, cell culture media, biopharm contract manufacturing, chromatography, lab informatics, lab automation, laboratory systems and equipment, molecular and cell biology, pipettors, assay instruments, genetic sequencing, immunochemicals, enzymes, hardware and software systems, and more.
BioProcess Online is part of the Life Science Connect media group. The vision of Life Science Leader and Life Science Connect is to help facilitate connections and foster collaborations in pharmaceutical and medical device development to find ways to get more life-saving and life-improving therapies to market in an efficient manner. Connect, Collaborate, Contribute.
Please take a moment to join our community and discover the benefits of your free membership.
BIOPROCESS ONLINE TWITTERBioresearch
It's Ten O'Clock. Do You Know Where Your Trial Master File Is?September 24, 2014
1pm-2:30pm EDT, Online Training
Partnership Strategies with CRO/Vendors: Create Relationships that Create ResultsSeptember 25, 2014
1pm-2:30pm EDT, Online Training
Qualifying Your Trainers – What Do They Need For Your Training To Be Effective?September 30, 2014
1pm-2:30pm EDT, Online Training
Authoring and Implementing Standard Operating Procedures (SOPs): Best Practices for SuccessOctober 1, 2014
1pm-2:30pm EDT, Online Training
Surviving a FDA GCP Inspection – Preparation Techniques for SuccessOctober 2, 2014
1pm-2:30pm EDT, Online Training
Delivering Biologics With A Difference
In this webinar you will learn about delivering intravenous-dosed biologics in an aseptically-filled intravenous bag and increase your understanding of the business drivers and potential value added with this strategy.
MAb Manufacturing: Where Are We Headed, Cost Or Capabilities?
Following the discussion on monoclonal antibody (MAb) processing, partly conflicting observations can be made: some push costs in the foreground of process technology discussion, while others emphasize robustness and peace of mind (low risk).
Digital Signatures: Enabling Compliant Collaboration and Streamlined Corporate Governance
In this webinar, we'll focus on the middle office where life sciences organizations can achieve tangible operational improvements and cost savings.
It's Ten O'Clock. Do You Know Where Your Trial Master File Is?September 24, 2014
1pm-2:30pm EDT, Online Training
Partnership Strategies with CRO/Vendors: Create Relationships that Create ResultsSeptember 25, 2014
1pm-2:30pm EDT, Online Training
Qualifying Your Trainers – What Do They Need For Your Training To Be Effective?September 30, 2014
1pm-2:30pm EDT, Online Training
The HireLifeScience.com Career Fair 2014September 30, 2014
Edison, NJ
Authoring and Implementing Standard Operating Procedures (SOPs): Best Practices for SuccessOctober 1, 2014
1pm-2:30pm EDT, Online Training
NORTHERN CALIFORNIA'S LIFE SCIENCE ASSOCIATIONmore BayBio events...
- 09.22.14 -- Best Practices In Biomanufacturing Supplier Relations: Reducing Raw Materials Risks
- 09.18.14 -- Genmab And Seattle Genetics Expand ADC Collaboration; When To Invest In Protein Production
- 09.15.14 -- GSK Discusses The Transformation Of Biopharmaceutical Manufacturing: Single-Use Is Only Part Of The Strategy
- 09.10.14 -- AstraZeneca And Redx Ink R&D Deal On Tumor Genetics; QbD at Genentech
- 09.08.14 -- Merck And Advaxis Partner; FDA Fast Tracks VentiRx's Immunotherapy For Ovarian Cancer


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Forget finding your soul mate, now you can find your long lost style mate thanks to sites like Poshmark. Users can buy and sell fashion from their closets, straight from their mobile phone.
"What we wanted to do was make it super simple for women to be able to realize the value of the treasures that sit in their closet," said Manish Chandra, Poshmark founder and CEO.
"When you're about to list something on Poshmark you take four photos, upload them, write down what it is, describe what you are selling," said Rosalie Yu, a Poshmark user.
"Women are uploading more than a million dollars of inventory every day," Chandra said.
As soon as a sale is made, Poshmark will email the seller a shipping label and the item can be sent out right away. Poshers can take it one step further, by attending a posh party.
"Posh parties are teamed events that happen within the app women across the country can buy and sell at the same time together," Chandra said.
Note that Poshmark does take 20 percent of the sale.
Whitney Spinelli and Michelle Epstein, two self-proclaimed fashionistas, have created their own version of a Poshmark through the social media site Instagram. They snap pictures of their gently worn clothes and put them on the Instagram page called "Whitney's Closet 1," appropriately named after its creator.
"I love fashion, clothes, love how it's an expression of yourself," Spinelli said. "But I am a bit impulsive and indecisive so I go through clothes more quickly than other people so that's where it comes in that I sell them."
In just a few months, the Closet has gained thousands of followers. Everything is deeply discounted: from tops, to designer jeans, and accessories.
Interested buyers write "sold" under the comments and leave their PayPal email address. Once the transaction goes through, the girls pack up the piece and ship it out.
"A lot of time we will find a great sale and find out the piece won't work for us, and it's final sale, so we can't return so we give that sale to someone else who it might work for," Epstein said.
Now every woman can have a revolving closet at the click of a button.
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A rib fracture is a break in a rib bone. Bruised muscles and ligaments often happen with a rib fracture. With a rib fracture, the lungs and other organs can be injured. More than one rib fracture after a trauma can indicate serious internal injury.
Rib fractures are caused by:
- A direct blow to the rib
- Crushing of the chest, such as in contact sports or a car accident
- Severe coughing incidents that can occur with lung problems or at high altitude
- Rib fractures in young children are often a sign of abuse
Risk Factors
Factors that may increase your risk of breaking a rib include:
- Age: 65 years and older
- Difficulty doing activities of daily living
- Playing contact sports
- Having weak bones
- Having a chronic cough
Extreme repetitive upper body activity, such as in:
- Throwing athletes
- Basketball players
- Golfers
- Rowers
- Weight lifters
- Having an occupation involving a lot of overhead lifting
- Having a history of rib or chest fracture
Symptoms include:
- Pain in the ribs or upper chest area
- Pain when coughing
- Swelling and bruising in the fracture area
- Severe local tenderness in the fracture area
- Internal bleeding
- Pain while breathing
The doctor will ask about your symptoms and how the injury occurred. Your chest, lungs, and back will be examined.
Images may be taken of your bodily structures. This can be done with:
Treatment includes:
Rest and do not do physical activity until the pain has gone away.
Your doctor may suggest wearing a chest binder around your ribs to protect them. The binder will also help you breathe properly. It is important to take some good breaths so that the lungs remain clear. Pneumonia can develop after rib fractures if you are not breathing deeply enough. If you play contact sports, you may need to wear a rib cage protector for 6-8 weeks when you return to playing.
Your doctor may recommend that you take over-the-counter medication to help reduce inflammation and pain, such as ibuprofen.
Physical Therapy
As your ribs heal, a physical therapist can teach you breathing exercises. The therapist can also help you maintain range of motion in arm and shoulder joints.
Intercostal Nerve Blocks
Special injections with local anesthetic can temporarily relieve pain.
Epidural Anesthesia
Sometimes, a temporary epidural catheter is used to place anesthetic near the spinal cord and nerves. This can help severe cases where the injury requires hospitalization.
Hospitalization is usually only needed if there are complications such as damage to organs in the chest.
Sometimes rib fractures cannot be prevented. To reduce your chance of fracturing a rib:
- Wear protective equipment, such as rib pads, when playing contact sports.
- Avoid over-training.
- Learn the proper technique for exercise and sporting activities.
Maintain strong bones by:
- Getting plenty of calcium in your diet
- Doing weight-bearing exercise
- Not smoking
Revision Information
- Reviewer: Michael Woods, MD
- Review Date: 09/2013 -
- Update Date: 09/30/2013 -


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Surprising politicians who made a splash
Published On: Oct 25 2011 09:06:06 AM PDT Updated On: Feb 05 2014 07:19:26 AM PST
Former "American Idol" star and singer Clay Aiken (D) recently announced his candidacy for Congress. Take a look at political figures with the most unusual resumes.
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Kevin Ware's New Dog
"Scar" will help him heal
Please note comments are moderated. After being approved your comment will appear below.
Submitted by Momma Suzzi | April 5 2013 | Permalink
I have had a loving companion Lucy (Border collie mix, adopted from the pound in 2003) she has been a constant companion of my families. Our relationship was taken to a whole other level of protection and security in 2005. Lucy was in our home when my son and his girlfriend died tragically. when I returned home , and was able to retrieve my beloved pets they were constantly at my side. Throughout the coming years as I navigated enormous grief, my companion Lucy has been by my side, walking with me, nuzzling my hand when she knew I was suffering emotionally, giving me kisses and clearing the tears from my tear streaked face. She is a faithful copilot and companion. She Loves me and we navigated a messy grieving process together. She too had lost her loved ones.
my husband passed away 9 years ago in his sleep, he was only 47, if I hadnt had my 2 chihuahua's I would have been in a very bad place in my life. I love my babies like they were my own
I think this is great. A pet always helps one to feel better. My concern is what is going to happen to Scar, when Kevin get's back on his feet and starts to play basketball again? Is the dog going to be forgotten about, have no time for, or what? I pray that that does not happen.
Submitted by Tanice | April 5 2013 | Permalink
I injured myself in a ATV accident, and was down for months. My dog helped me keep my sanity!
Submitted by Paula Walker | April 5 2013 | Permalink
Good for you Kevin! Hope this animal helps you heal - I think you will be surprised how much it will help! Speedy Recovery!
Submitted by Ellie | April 5 2013 | Permalink
What kind of a dog? Who else is in the home to care for the dog? All the best to them both.
My dogs have helped me thru many crisis' some health, some when I moved to a new location by myself for the first time and others when I was just stressed out. Of course my dogs have caused alot of my crisis' too lol. I love them more than life itself and wouldn't have it any other way!!!
When I was down and out with panic attacks and depression, my dog was always there for me, kissing my tears and lying with her head in my lap. I'd have been lost without her. Dogs are simply the best.
Submitted by renee | April 5 2013 | Permalink
welcome to the dog loving family. the puppy will help you. i hope you heal and go back to your sport.
Submitted by joan hart | April 5 2013 | Permalink
You have picked the best companion ever, not only through your healing process but forever. When I broke my neck in a car accident my Jack Russell Ivan knew to come to me on the couch and say okay I know you need to heal but perhaps you could take me for a walk in the park and get fresh air and you will heal much quicker. He was right it was the best thing. I fell into a deep depression as the injury changed my whole life and he made me realize that I could not stay in such a dark place wallowing in my own misery.
Submitted by Jackie | April 5 2013 | Permalink
I have severe anxiety that leads to seizures. My dog, Jenna, the was rescued from a puppy mill can tell when my anxiety is at it's worst and calm me down. One thing she does is lick my hands and arms to get the blood to return to them, like she would a puppy. Sometimes she knows I'm at the point of seizing before I do. I am so glad I have her to comfort me.
Submitted by J Newfeld | April 5 2013 | Permalink
Prayers for a speedy recovery, and YES, a resounding YES, animals can help a person heal faster. Thank you for adopting Scar. I know you will become good friends in your recovery of injury and afterwards.
Submitted by Anonymous | April 6 2013 | Permalink
I just had knee surgery; my 95lb, 9-year-old-greyhound/lab mix would not leave my side. When my son tried to take him for a walk, he broke the leash ands ran back to me. Over the 9 years Ive had Elvis he's helped me through many a hard time-I would say Kevin is lucky to have Scar by his side (although he looks like a puppy, so that sounds harder to me) get well kevin...
Submitted by Anne Ridderhoff | April 6 2013 | Permalink
Nothing will keep his spirits up like an dog will. Being away from basketball for a guy who's used to doing it everyday will be difficult but he will have his dog Scar to tell his feelings to. I have a cat and for the better part of her life I leaned on her to get me through the loss of my 25 year job, the illness of my husband and the illness and death of my mother. Believe me she has been my rock. And Scar will be Mr. Wares rock. Good for you Kevin Ware for giving this dog a loving home.
Submitted by Terry | April 6 2013 | Permalink
YEAH!!! I have been laid up since Nov 2012 with a broken ankle. I am just learning to walk. I have 2 beagles who have been a God send to me. I know if I did not have them here at home making my day better, the depression would have been a TON worse! They have been an inspiring part of my everyday of being housebound. I hope his dog gives him the same inspiration! That dog is lucky to have a buddy!
Submitted by Judy L | April 7 2013 | Permalink
oh yes . . . my dogs were my companions when I was home from work and going through cancer treatments. they are the BEST companions ever!!!
Submitted by Lil I. | April 9 2013 | Permalink
When I was going through chemo for ovarian cancer, the dog we had at the time (a Sheltie) stayed close to me all the time, especially when I would would home from a treatment. Animals seem to sense when you are not well. Right now my husband is not doing well and the Cavalier King CharlesSpaniel/Dachs mix (whom we adopted a few months ago), jumps up in his lap periodically as if to say, "I'm here if you need some loving".....
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WASHINGTON | Tue Jul 16, 2013 9:06am EDT
(Reuters) - U.S. consumer prices rose more than expected in June as gasoline prices jumped and underlying inflation pressures stabilized, keeping on track expectations the Federal Reserve will start scaling back its bond purchases later this year.
The Labor Department said on Tuesday its Consumer Price Index increased 0.5 percent, the largest increase since February, after nudging up 0.1 percent in May. Gasoline prices accounted for about two thirds of the increase in the CPI.
Economists polled by Reuters had expected consumer inflation to increase 0.3 percent last month.
In the 12-months through June, consumer prices advanced 1.8 percent after rising 1.4 percent in May. It was also the largest increase since February.
Stripping out volatile energy and food, consumer prices increased 0.2 percent for a second straight month. That took the increase over the 12 months to June to 1.6 percent, the smallest increase since June 2011. The so-called core CPI had increased 1.7 percent in May.
While both inflation measures remain below the Federal Reserve's 2 percent target, details of the report suggested the recent disinflation trend had probably run its course, with medical care costs rising.
Fed Chairman Ben Bernanke, who last month said the central bank would start cutting back the $85 billion in bonds it is purchasing each month to keep borrowing costs low, has viewed the low inflation as temporary and expects prices to push higher.
Alan Ruskin, an analyst at Deutsche Bank in New York, said the report should "counter arguments that there is a material deflation risk."
"The data does not provide much support for Bernanke making too much of low inflation in again asserting the dovish outlook he provided last week," he said.
There were also increases in the prices for new motor vehicles, apparel and household furnishings. That could keep on track expectations the U.S. central bank will start scaling back its massive monetary stimulus in September.
Last month, gasoline prices soared 6.3 percent after being flat in May. June's increase in the cost of gasoline was the largest since February. When unadjusted for seasonal fluctuations, gasoline prices rose only 0.6 percent.
Food prices increased 0.2 percent after slipping 0.1 percent the prior month.
Overall housing costs maintained their steady rise, with owners' equivalent rent - which accounts for about a third of the core CPI - increasing 0.2 percent after a similar gain in May.
Medical care services rose 0.4 percent after being flat in May, while medical care commodities rebounded 0.5 percent as the cost of prescription drugs increased. Medical care commodities had dropped 0.5 percent the previous month.
Weak medical care costs have been the one of the key contributors to the low inflation rate.
Economists cite a host of reasons for the low health costs, ranging from the expiration of patents on a number of popular prescription drugs to government spending cuts that are reducing payments to doctors and hospitals for Medicare.
"It's unclear we have seen all the medical care softness or we might see softness later this year from the effect of sequester," said Laura Rosner, an economist at BNP Paribas in New York.
Apparel prices pushed up 0.9 percent, the largest increase since August 2011, after edging up 0.2 percent in May.
New motor vehicle prices increased 0.3 percent. They had been flat in May. Prices for used cars and trucks fell for a second straight month.
(Reporting by Lucia Mutikani; Additional reporting by Richard Leong in New York; Editing by Andrea Ricci)


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Moderators: Jenise, David M. Bueker, Robin Garr
Good crisp lettuce, quality mayo (if not homemade) and for me, always rye toast.
Karen/NoCA wrote:Anyone know that good rye bread that is marbled into a beautiful swirl pattern with dark and light rye? I love that bread not only for the rye taste but the beauty of it.
Jenise wrote:No mayo! Just butter the toast.
Frank Deis wrote:Karen/NoCA wrote:Anyone know that good rye bread that is marbled into a beautiful swirl pattern with dark and light rye? I love that bread not only for the rye taste but the beauty of it.
If you watched Seinfeld (which I kinda doubt) you would know that there was an entire show about exactly that kind of rye. There was a hilarious scene where George had a fishing pole stuck out of the window, reeling up the loaf of marble rye... But you probably had to be there.
GeoCWeyer wrote:Sliced cracked wheat bread, toasted. Fresh home grown or farmers market tomato, peeled and thickly sliced, Hellmans or Best mayo, spread on the top slice of toasted bread. The mayo has to be spread right up to the crust and not too thick! Then, instead of lettuce, leaves of freshly picked Italian basil. Thick sliced bacon fried to almost crisp and to complete the ingredients, some freshly ground pepper. The basil is placed on the bottom piece of toasted bread, then the bacon topped with the tomato and a little black pepper, covered by the mayo covered 2nd piece of toast.
Jeff Grossman/NYC wrote:What is the right knife to use to spread the mayo? Or, is it all good so long as I'm working under a pyramid oriented to true North?
GeoCWeyer wrote:It is not something that is just throw[n] together.
In many operations the waitstaff will also put together the standard side salad. You actually have to patiently teach them exactly the correct amount of dressing to be used. It is all part of a successful operation. It is these small things that make a great difference.
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The ancient method of hair removal through eyebrow threading is attributed most commonly to Indian origins, but has also been used for centuries throughout the Middle East and parts of East Asia. Threading in the United States is becoming more prevalent and readily accessible, and some people are starting to turn to eyebrow threading as their preferred method of hair removal. MODERN talked to Vas and Sonal Maniatis, owners of Seva Salon in Highland Park, who specialize in the art of brow-shaping and facial hair removal by threading and waxing.
MS: What are the benefits of eyebrow threading?
The Maniatis: Eyebrow threading allows for a finer and more polished brow line than waxing, as each row of hairs are removed one at a time with a precise motion. Threading is much less painful on sensitive areas of the skin, and many people typically experience less swelling, redness or irritation from threading than from waxing, an no chemicals are used. Threading is a much faster method than tweezing, because many hairs are pulled simultaneously.
MS: Why should a client choose eyebrow threading over waxing?
The Maniatis: Waxing typically removes the top layer of skin, resulting in a more painful experience than eyebrow threading. Women tend to prefer the precision of threading.
MS: For someone who wants to get involved in learning how to eyebrow thread, what are the steps? Do you need to be certified?
The Maniatis: Eyebrow threading is not traditionally taught in cosmetology school, so people that are interested in learning should seek out a class that teaches the art of threading. Things to be aware of are the instructor's credentials and the mission statement of the class. Find out if the class is associated with any retail threading establishments. Ideally the instructor should be a Master level threader, and it is beneficial if they also possess an esthetician or cosmetologist license, which means they have been properly trained in general hair removal techniques, sanitation, etc. It is always a plus if the instructor or threading school can help with job placement and career advancement.
MS: Why in your opinion is eyebrow threading growing in popularity?
The Maniatis: Threading really is a superior technique in all aspects than the traditional forms of brow shaping and facial hair removal such as waxing and tweezing. I think the popularity of threading is still in its infancy and we're only at the beginning stages of its growth curve.
MS: How can you attract customers to try the service?


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I have typed this post at least a half dozen times in the past few months, and then deleted it thinking things will get better. Girls, Im in need of some serious advice!
First, I want to say that DS2 can be one of the sweetest, loving little guys ever. I love him to pieces, but he has me stumped on how to correct this behavior.
Levi has always been a physically aggressive (major biter from early age, although now he just hits, kicks, and recently picked up spitting), destructive child. Lately, things have gotten so bad that our sitter refuses to watch him except for 2 days a week, and after the first of the year shes not going to watch him at all. (Her Dad is very sick, and watching him stresses her out.) This means that I am/will be splitting my kids up for childcare.
I have tried just about everything regarding his discipline. Timeouts are basically a joke to him, and now, instead of him sitting in his naughty chair (that he completely disassembled into a million pieces), I have to put his nose in the corner. Yesterday, he peeled a ginormous piece of paneling off of my wall like a banana peel while he was in TO. At that point, I was so frustrated that I didnt even know what to do with him, so I made him sit there until I could calm down. He was in TO to begin with for coloring all over the walls in his bedroom (for the 1,102,123,163, 235th time) at naptime with his brothers dry erase markers that were specifically for his studies. I find this out as soon as I walk in the door, so of course I feel like our entire evening together is me trying to discipline him for various things. I feel like Im on him all of the time, and we dont even get to enjoy each other.
So far today, hes kicked the little girl at the sitters and deliberately shut her fingers in the toy box (all right in front of her Mom, btw). He had to be separated from DS1 and little girl until lunch time, and hes napping now. When hes told hes going to TO, he stick his tongue out with a persistent NO and runs away. Its awful.
Okay, so, I guess Im just looking for ways to correct my childs behavior. DS1 was not this difficult for me. I can just look at him with my look, and he stops what hes doing. Levi laughs and keeps doing what hes doing. Its like theres no getting through to him, but here has to be a way!


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Açai oilClose
(Euterpe oleracea) It is a species of palm tree in the genus Euterpe cultivated for their fruit and superior hearts of palm, it is rich in polyphenols and do have a strong antioxidant action.
Alfalfa extractClose
(Medicago sativa) It is a perennial flowering plant in the pea family Fabaceae cultivated as an important forage crop in the US, Canada, Argentina, France, Australia, the Middle East, South Africa, and many other countries:it is rich in vitamin D and has a stenghtening and antiaging action.
it is a diureide of glyoxylic acid. it has soothing action on scalp.Can be found in:
Ammonium thioglicolateClose
also known as perm salt and reduces the disulfide cystine bonds in the cortex of the hair.
Anti-flaking factorClose
The formulas have been carefully calibrated to minimize the content of resins in order to reduce "flaking" but without losing the effectiveness of the product.
Apricot butterClose
(Prunus Armeniaca): originally from China, now the plant is spread in Europe and marica too. It is rich in vitamin A and C with hydrating and emmolient properties.
Apricot oilClose
(Prunus Armeniaca) originally from China, now the plant is spread in Europe and marica too. It is rich in vitamin A and C with hydrating and emmolient properties.
Argan oilClose
(Argania spinosa) is an oil produced from the kernels of the argan tree, endemic to Morocco, that is valued for its nutritive, cosmetic and numerous medicinal properties. its seeds are strong antioxidants
Artichoke phytoceuticalsClose
Artichoke (Cynara cardunculus var. scolymus) is a perennial thistle of the genus Cynara originating in Southern Europe around the Mediterranean it is antioxidant and detoxyfying.
Avocado oilClose
(Persea americana) is a tree native to Central Mexico, it is rich in potassium, vitamin B, E and K, fibres and monoinsaturated fats: it has an emmillient action.
Barly extractClose
(Hordeum vulgare) it is a major cereal grain, a member of the grass family: it provides body to the hair.
They are polysaccharides of D-glucose monomers linked by β-glycosidic bonds and do have a protective action on the cells.
marine derivative that intervenes on hair structure replenishing it with all the elements lost: mineral salts (calcium, magnesium, iron, silicon, zinc and copper) proteins and vitamins.
Black cohoshClose
Or Actaea racemosa is plant extract that block the 5-αreductase enzyme, responsible for androgenetic alopecia and hypersebaceus production.
Blend of biodegradable surfactantsClose
Respect the skin and hair structure leaving them soft and silky. The biodegradable surfactants chosen by Davines are Eco-friendly
Blue pigmentClose
Anti-yellow action;Can be found in:
Blueberry phytoceuticalClose
(vaccinium) It is a genus of shrubs or dwarf shrubs in the plant Family Ericaceae, is rich in polyphenols and sugars with a strong anti-oxidant action.
Borage seed oilClose
(bot: borago officinalis L.):also known as a starflower, is an annual herb originating in Syria. The seed oil is desired as source of gamma-linolenic acid. It provide protection to the hair
Breathable siliconsClose
Mix of last generation breathable silicone oils that create a protective film on the hair structure without affecting the performance of subsequent treatments. These ensure product versatility that respects the structure of all hair types.
Burnet extractClose
Hardy, perennial, herbaceous (i.e., nonwoody) plant of the genus Sanguisorba (also called Poterium), within the rose family (Rosaceae), it normalize the sebum production.
Caffeine phytoceuticalsClose
Caffeine is a bitter, white crystalline xanthine alkaloid that acts as a stimulant drug. It is most commonly consumed by humans in infusions extracted from the seed of the coffee plant and the leaves of the tea bush, as well as from various foods and drinks containing products derived from the kola nut: it has a stimulating activity
Extracted from tomatoes have a strong anti age action because fight against free radicals , responsible of aging;
Carrot extractClose
(daucus carota L):is a root vegetable, usually orange in colour, though purple, red, white, and yellow varieties exist, It is a domesticated form of the wild carrot Daucus carota, native to Europe and southwestern Asia.The carrot gets its characteristic and bright orange colour from β-carotene, which is metabolised into vitamin A in humans when bile salts are present in the intestines. Massive overconsumption of carrots can cause carotenosis, a benign condition in which the skin turns orange. Carrots are also rich in dietary fibre, antioxidants, and minerals.
Cashemere proteinsClose
Is a fiber obtained from Cashmere and other types of goats. The word cashmere derives from an old spelling of Kashmir. Cashmere is fine in texture, and strong, light, and soft. Garments made from it provide excellent insulation. it ha restructuring action.
Chelating agentsClose
Used to link heavy metals and avoids them to attach the hair structure.
Cherry oilClose
(bot Cerasa) the oli that is extracted is rich in vitamins A,B and C with nourishing and repairing properties.
Chestnut milkClose
(Castanea) It is a genus of eight or nine species of deciduous trees and shrubs in the beech family Fagaceae, native to temperate regions of the Northern Hemisphere. Provides depp nourishment and hydration.
Cinnamon extractClose
It is a spice obtained from the inner bark of several trees from the genus Cinnamomum that is used in both sweet and savoury foods. While native only to the island of Sri Lanka, cinnamon trees are now naturalized in South East Asia:it normalize the sebum production.
Row material comes from north of Italy; it absorbs all the impurities on scalp and hair.
Conditioning agentsClose
give hair silkiness and softness hair;
Corn StarchClose
Active ingredient of natural origin used for its antistatic and thickening properties.
Creamy emulsionClose
To garantee perfect colour application.
(Cucumis sativus) is a widely cultivated plant in the gourd family Cucurbitaceae, which includes squash, and in the same genus as the muskmelon.it has depurative and detoxifying action.
Cyamopsis TetragonolobaClose
This guar bean offer a strong moisturizing actio. It is principally grown in India and Pakistan, with smaller crops grown in the U.S., Australia, China, and Africa. In India, Rajasthan and Gujarat are the main producing regions, while Jodhpur in Rajasthan is a major Guar trading market.Can be found in:
Is an amine that has a reductive action, tend to break down the disulphide bonds.
Dandelion phytoceuticalsClose
(Taraxacum) It is a large genus of flowering plants in the family Asteraceae. They are native to Eurasia and North America, and two species, T. officinale and T. erythrospermum, are found as weeds worldwide, is rich in polyphenols and sugars with anti-oxidant action, and anti-inflammatory action.
Direct pigmentsClose
Pigments that colour directly without the help of the activator, simply staying in contact with the cuticle and do not penetrate the cortex. They are used either to intensify the natural or cosmetic colour of the hair or to contrast natural reflection;Download PDF for more information


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Catholic universities across the United States say they would tell student groups distributing condoms on campus to stop and would potentially threaten disciplinary action, just as Boston College did earlier this month.
At BC, officials sent a letter to a student group that organized condom pickup spots on campus, citing the university's mission as a Catholic institution and demanding that they cease or face possible discipline. The letter provoked angry reaction from some students and the local chapter of the American Civil Liberties Union, which said it might pursue legal action.


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photo 1 of 80
Brian Ebersole
TRAINING: There's no such thing as a typical day. Some days, I'm on fire and feel unstoppable. Other days, my partners make me feel like I should retire!!! But that back and forth is what keeps me evolving, keeps me working, and helps me prepare for the adversity and opportunities that are present in each fight.
Getty Images reserves the right to pursue unauthorized users of this image or clip. If you violate our intellectual property you may be liable for: actual damages, loss of income, and profits you derive from the use of this image or clip, and, where appropriate, the costs of collection and/or statutory damages up to $150,000 (USD).


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photo courtesy of dreamstime.com
Hitting Irons straight has always been an issue with me. One day they go straight, next day everywhere but straight. We've all been there. I'm always looking for tips that could maybe help solve that problem. Check out this little video tip.....I'm gonna try it, let you know how it works.


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Proforged developed these sway bar end links to meet the demands of today's performance enthusiast. Proforged sway bar end links are lab-tested and real-world proven to be durable and reliable, even in the most demanding conditions.
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Bible Blocks 12 x 8 feet 4 inches
$464.50/ piece
Based on Old Testament stories, Bible Blocks can be an excellent teaching tool when kids are learning moral stories in the Bible or Torah. This is a beautiful ruth also has the letters of the alphabet and numbers 1-9. Includes a teaching manual with learning games. Shipping costs obtained online are only valid for orders shipping to the lower 48 states.
This Product Ships UPS Ground, FedEx Ground and/or Freight.
Please review our shipping disclaimer.
NOTE: This item is a custom order and is not returnable.
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The AccuCision™ method of endoscopic hand surgery uses the newest developments in micro-invasive medicine to operate through the smallest incision port possible. Conventional "open" methods of hand surgery can leave the patient with scars several inches long – AccuCision™ carpal tunnel surgery leaves two tiny incisions, neither greater than 4mm-7mm in length. Learn why patients choose AccuCision™ with Renova Doctors.
Our orthopedic surgeons use a micro-invasive Carpal Tunnel Release procedure get patients back to life faster.
Stitchless Trigger Finger Release that avoids large incisions and extensive scarring.
Effective Cubital Tunnel Rlease that releases pressure on the ulnar nerve with minimal scarring.
PRP treatment is the cutting edge in hand rejuvenation therapy, delivering natural and safe results with no downtime.
A common hand condition that causes numbness in fingers, wrist pain and aching palms.
A benign lump that forms near the joints of the hand and wrist.
Tendon swelling that can force the fingers into a locked or bend position.
Pressure on the elbow's ulnar nerve that results in tingling and numbness throughout the arm.
Gradual or sudden swelling, pain and numbness that extends from the wrist into the fingers.
Diseased hand tissue that hardens and forces the fingers to contract toward the palm.
With so many anti-aging treatments on the market, it can be hard for consumers to find what really works. What's ...
Platelet Rich Plasma Therapy, or PRP is a procedure that uses the healing power of platelets and growth factors ...
When it comes to concealing signs of aging, most people focus on their faces, necks and hair. But did you know your ...
If your kids plan on using fireworks this Fourth of July, make sure to watch this video first. Dr. Loredo tells NBC ...


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THREE LAKES, WI (WSAU) - At least 19 people have died in Wisconsin snowmobile crashes this winter. The latest reported death was on Saturday. Oneida County authorities said 31-year-old Dean Katsaros Junior of Willow Springs Illinois lost control of his machine and slammed into a tree near Three Lakes. He died at the scene, and the crash is still being investigated.
According to the D-N-R's Web site, Wisconsin has not officially recorded a snowmobile death since March third – although there's been plenty of snow on the ground in most places.
There was a report of a snowmobile death on March 16th in Langlade County, but sheriff's investigators said they found no immediate evidence of a crash at the time. They said it's possible the rider may have died from exposure before going onto a lake.


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My beloved Minnesota Twins are terrible again this year. I still try to catch as many games as I can, regardless of their record. I suppose I'm a glutton for punishment.
At least a few times each year all teams take a trip to the west coast to face teams like L.A. and Seattle. Because of the time difference, a first pitch set for 7:05pm locally is after 9pm in our neck of the woods. Considering a game lasts close to three hours, that means a bedtime of around midnight.
I can deal with the lack of sleep. What really gets me is when I fall asleep and wake up the next morning only to realize that I missed a great game.
As I drifted off to dreamland last night, Minnesota was down a few runs to the Angels. Little did I know, Minnesota tied the game at 3-3 going into extra innings. That's when it got really good!
Third-string catcher Chris Hermann blasted his first career grand slam en route to a 10-3 Twins victory.
Of all the games I consume throughout the year, chances are that I won't see many grand slams to win it for the good guys in extra innings.
On the bright side, the Twins wrap up their series in Anaheim this afternoon. And, it's tough to beat late afternoon baseball during the week.
*image courtesy of: Pixabay.com


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Starting Position: Lie on your back with your knees bent and both feet flat on floor. Your arms are out to your sides in a "T" position palms facing up.
Downward Phase: Exhale. Using your abdominal muscles, press your low back into the floor. Do not lift your hips or let your tailbone roll up off the floor. Hold this position briefly.
Upward Phase: Inhale. Tip your pelvis in the opposite direction creating an arch in your low back/increasing the space between the low back and the mat. Do not lift your hips or let your tailbone roll up off the floor Hold this position briefly before returning to your starting position.
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Canadian geese are known to fly in a "V" shape pattern as they migrate across the country. The lead goose in the "V" cuts through the air making it easier for the rest of the geese behind him. As that lead goose becomes tired, he will drop off and join one of the sides and a new lead goose will take over. This is done several times as they are flying long distances.
Q: So if you look up in the sky and see a "V" shape pattern of geese flying overhead and one side is longer than the other, do you know what that means?
A: There are more geese on that side.
Q: And if you see a family of geese crossing the street, do you know what that means?
A: They have just landed and they are taxiing back.


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Is your family split between the Green Bay Packers and Minnesota Vikings? KELO Ben Dunsmoor, and his wife Trista, are rooting for either during Thursday Night Football at Lambeau Field.
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|0. PostgreSQL/EnterpriseDB Stack Builder - The Stack Builder is a download and installation wizard combined with a set of pre-configured packages to complement PostgreSQL's one-click installers on Windows, Mac and Linux.
|Activity Percentile: 75.20
Activity Ranking: 32.00
Registered: 2007-02-15 19:56
|1. gm2pgsql - This is a command-line tool for exporting Intergraph
Geomedia Warehouse to Postgis SQL file. It works
like the famous shp2pgsql.
The tools works only in win32 and and uses odb32lib to read
mdb file and do not required to install Microsoft Access.
|Activity Percentile: 16.80
Activity Ranking: 105.00
Registered: 2009-04-02 08:27
|2. psqlODBC - psqlODBC is the official PostgreSQL ODBC Driver.
Downloads are available on the PostgreSQL Mirror network at http://www.postgresql.org/ftp/odbc/, and support from the firstname.lastname@example.com mailing list (http://archives.postgresql.org/pgsql-odbc/).
|Activity Percentile: 0.00
Activity Ranking: 0.00
Registered: 2005-07-14 07:59
|3. Open Business Accounting (OBA) - OBA is a web based business accounting software modified from sql-ledger to suit accountants ,auditors and who required massive data entry. it comes with some new modules such as quick-entry, sales summary, unique transaction number...
|Activity Percentile: 0.00
Activity Ranking: 0.00
Registered: 2004-05-18 16:44
|4. PostgreSQL installer - This is the MSI installer for the PostgreSQL database server. As of PostgreSQL 8.4, this installer is no longer being maintained.
Download from the mirror network at http://www.postgresql.org/ftp/binary/
|Activity Percentile: 0.00
Activity Ranking: 0.00
Registered: 2004-05-04 21:12