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Old-Time Gums (Box of Twenty 5-Stick Packs)
Black Jack Gum, Beemans Gum, and Clove Gum—Only While Supplies Last
Old-Time Gums (Box of Twenty 5-Stick Packs)
Black Jack Gum, Beemans Gum, and Clove Gum—Only While Supplies Last
Black Jack Gum, Beemans Gum, Clove Gum—taste again the delight that comes with every chew of these fondly remembered gums from back in the day when gum came only in a stick and was meant simply to please. Black Jack gum, the first flavored gum in America, has been a black-licorice favorite since 1884. Beemans gum was invented in 1898 to ease heartburn, owing to the pepsin—a digestive aid—it originally contained. Clove gum has been valued as a breath freshener since the Prohibition. All three flavors come in boxes of twenty 5-stick packs.
- Black Jack gum is black licorice-flavored
- Beemans gum was invented in 1898
- Clove gum freshens breath
Old-fashioned candies and gum deliver up as much pleasure from their taste as from the memories they invoke, like Black Jack Gum, Beemans Gum, and Clove Gum. There's a memory in every chew of one of America's original chewing gums.
Old-Time Gums (Box of Twenty 5-Stick Packs)
This is not a Kosher product.
Sugar, gum base, glucose syrup, artificial and natural
flavoring, glycerin, soy lecithin and BHT (to maintain
Black Jack also contains: caramel color, blue 2 lake, red 40
lake and yellow 6 lake.
Shelf Life: 16 Months
|Nutritional Item
|% of Daily
|Serving size: 1 stick (2.5g)
|Calories: 10
|Calories from fat: 0
|Total fat
|Trans fat
|Total Carbohydrate
Manufactured In: Colombia
Material - Country Of Origin: Colombia
What Our Customers Are Saying about Our Old-Time Gums (Box of Twenty 5-Stick Packs) …
"I loved this gum as a child and would find it sometimes in different stores like Cracker Barrell or Bob Evans or Perhaps a Rural King. Then it is gone - so I was happy to find it at your store. I have purchased two and ordering my third box - as my grandson loves it too, and he is 4 - so he is starting out like his Nana did in the 1940's." - Kay White, Lake St. Louis, MO
"My husband, David, passed away in 2003 when my children were 11 and 7. He loved Clove Gum and chewed it all the time. My children have always associated the gum with their dad and to this day love the scent and taste of clove. When the gum is available we buy what we can, unwrap, enjoy, and remember their dad with great love and affection. " - Kathy Wanzer-Carlsen, Ipswich, MA


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Active Ingredients
Phenylephrine HCl (0.125%).
Inactive Ingredients
Benzalkonium Chloride Solution, Edetate Disodium, Glycerine, Polyethylene Glycol, Potassium Phosphate Monobasic, Water (Purified), Sodium Phosphate Dibasic.
Easy to use dropper bottle hold bottle upside down and squeeze lightly.
STORE FEATURES: We stock and ship Genuine, new and manufacturer direct products. We don't sell used, expired, knock offs or copies.

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Customer Reviews for Sidelights Privacy
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Up to 20% of US Kids Have Mental Disorder
(NEWSER) – The CDC is out with its first report on mental disorders and kids, and the bottom line is a pretty heavy one: 13% to 20% of kids between ages 3 and 17 now suffer from a mental disorder, per the AFP. And that has costly implications: The disorders spur $247 billion in medical, special ed, and juvenile justice costs every year, says the report, which defines said disorders as "serious deviations from expected cognitive, social, and emotional development." The report noted such diagnoses are on the rise, a determination made after reviewing data spanning from 1994 to 2011.


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Tanqua (FA8)
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* The Base Rate amount is charged for any number of guests occupying a unit not exceeding the base number for that activity type (in this case 4)}. Any additional Adults and Children exceeding the base capacity are charged in addition to the base rate amount per persons up to the amount of beds or guests allowed in the unit.
- 1 en-suite bedroom with a double bed
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- Fully Equipped
- Kitchen
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- Outside braai facilities
- Restricted 220v power
- Self Catering
- Wc, shower and bath


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The Meeker cast of "Alice in Wonderland" is lined up before their Friday and Saturday night performances of the play at Meeker High School.
The Meeker cast of "Alice in Wonderland" is lined up before their Friday and Saturday night performances of the play at Meeker High School.
RANGELY I Fifty-four Rangely elementary, middle and high school students performed Missoula Children's Theater's "Alice in Wonderland" on Friday night, bringing approximately 300 people to the Rangely Junior-Senior High School auditorium.
MEEKER I Downtown Meeker will be abuzz from early morning to mid afternoon on Saturday with the 11th annual Mountain Valley Bank Fall Festival.
RANGELY I Colorado Northwestern Community College dental hygiene faculty Barbara and Mark Patterson are used to adventures. They've shepherded generations of students into an ever-evolving profession. They have been a part of that evolution themselves. They wouldn't have had it any other way.
RBC I First National Bank of the Rockies officially became the Bank of the San Juans last week after the oldest banks in Meeker and Rangely were acquired by Montana-based Glacier Bancorp Inc.
RANGELY I College officials, local dignitaries and the Rector family were on hand Thursday for the dedication of the refurbished and enlarged Rector Science Building on the campus of Colorado Northwestern Community College in Rangely.
MEEKER I Below are the finals and the final results from the 2014 Meeker Classic Sheepdog Championship Trials, held Sept. 3-7 in Ute Park at Meeker, Colo.
RANGELY I Mossie Percifield hit the century mark Aug. 8, 2014, celebrating her 100th birthday. A century of love, laughter, work and devotion to
MEEKER I Trappers Lake was not among the places protected by the Wilderness Act upon its passage in 1964. Rather, the creation of a Flat Tops Wilderness Area that included the lake exemplified how the Wilderness Act guided the wilderness debate during the late 20th century.
Approximately 300 children arrived at Rangely's town square to play games, ride horses, win prizes and consume their fair share of sugar on Aug. 5 at the Rangely Library's annual summer reading carnival.
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Personalized Glass Coasters Set of 4 Style 1158
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Modern and stylish these personalized glass coasters have a classic appeal. They make the perfect gift for treating others or yourself!
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Poptent is an integrated and fully managed suite of video marketing services with video production,
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Michael B. Coleman, Mayor
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9/22/2014 12:00:00 AM - High-tech Recycling and Trash Containers to be Installed in the Short North
The City of Columbus has purchased specialized smart recycling and trash containers for the Short North that can sense a container's capacity and alert city crews to the need for collection.- read more
8/19/2014 12:00:00 AM - Mayor Michael B. Coleman Presents MOMENTUM
Registration is now open for the 12th Mayor's Small Business Conference & Expo. This year's summit of small business enterprises will take place October 8 – 9, 2014 at the Hilton Columbus Downtown and the Greater Columbus Convention Center.- read more
7/23/2014 12:00:00 AM - Create Columbus Announces Funding For Young Professional Initiatives
The Create Columbus Commission (Create Columbus) is pleased to announce the recipients for the organizations 2014 grant cycle. Create Columbus received more than $460,000 in requested support, ultimately awarding a total of $82,000 to 11 programs that advance the interests of young professionals in Columbus.- read more
7/21/2014 12:00:00 AM - State of Ohio Partnership Expands Early Start Columbus
Joined by Gov. John R. Kasich, Mayor Michael B. Coleman today announced a partnership with the State of Ohio to expand early learning programs in Columbus. Through this partnership, funding will be available for quality pre-K providers to serve 160 additional low-income four-year-olds.- read more
07/11/2014 - Mayor Coleman's Twilight Bike Ride
The Rich Street Bridge will be closed for staging of the race from 3 p.m. to about 11 p.m. Friday. The Broad Street Bridge and the Main Street Bridge are good alternates.- read more
03/17/2014 - Mumps Information
Mumps is a viral illness that affects the salivary glands. It is spread when an infected person coughs or sneezes, and a non-infected person inhales respiratory droplets that contain the virus. Symptoms include fever, body aches, headaches and swelling of the salivary glands under the ears or jaw.- read more
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"Do you know someone who needs health coverage? Help them find assistance shopping for coverage at ohioforhealth.org. This video covers four easy ways to find assistance using ohioforhealth.org."- read more
If you have a passion for the arts, Columbus, Ohio is the place to be. The Places Almanac calls Columbus "one of the nation's best metro areas for the arts." You'll find world-class museums, theatre productions and musical performances, ballet, opera and much more.
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Columbus is a leading sports destination and hosts events throughout the year, including professional, collegiate and high school sports, NCAA Championships, PGA Tour events and world-class sports festivals.- read more
Check out the hot spots and happenings around town with the Experience Columbus Facebook photo albums. These artful shots of dining, arts, sports, architecture, events and more reveal Columbus, Ohio like you've never seen it before.- read more
Columbus Art Walks and Landmark TalksThis guided tour series runs June 2 through October 12, 2014. Join a FREE guided tour of all of our art walk districts. A wonderful way to see just how easy it is to walk in Columbus neighborhoods. Tours are totally family friendly too! - learn more
COSICOSI offers extended hours and price reduced admission to families so you can visit, learn, and play late! Includes all of COSI's permanent exhibitions plus a movie on the 7 story Extreme Screen theater. Watch and participate in learning about science in a fun way through hands on activities and demonstrations. Visit
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A significant winter storm is brought snow and rain to the tristate region but was not as bad as anticipated.
The largest snowfall total in the metro region was in Tuxedo Park, N.Y. with 5".
The National Weather Service says Jersey Shore residents were buffeted with winds as high as 74 mph.
In northern and western areas of N.J., some communities got more than six inches of snow.
The Long Island Power Authority says about 5,000 customers are without power, most of them in Nassau County.
Con Edison is reporting about 1,300 customers without electricity in New York City and Westchester County.
In New Jersey, Jersey Central Power & Light reported about 5,200 outages, with the bulk occurring in Monmouth County where the utility serves about 280,000 customers. PSE&G, the state's largest utility, is reporting about 450 outages in central and northern New Jersey, with about half in Mercer County.
Subway, bus and rail service is normal. No delays are reported at the area airports.
A winter storm warning for parts of New York and New Jersey remained in effect until late Thursday morning.
New York Gov. Andrew Cuomo activated the State Emergency Operations Center to monitor the storm and any emergency needs.
"Winter weather has arrived for many parts of the state, so as a precaution we have opened the emergency operation center to coordinate response efforts using all state and local resources," Governor Cuomo said.
Several roads were closed because of storm-related problems. A light pole fell onto the Harlem River Drive near 139th Street, closing the road for a while. The Taconic State Parkway was also closed between SR-6 and I-84 for a few hours.
Clouds increased throughout Wednesday as showers made their way from southern New Jersey to the northeast across the area and into Connecticut.
The snow converted to rain in New York City by evening and intensified overnight.
Up the Hudson Valley and into the interior locations in N.J., N.Y. and Conn. those areas saw snow accumulations in the 3- to 5-inch range. But heading even further north west into western Passaic, Sussex, and Warren counties, those areas could see snow totals of 8 inches or more.
The wind throughout the tristate region will be very strong through Thursday, with sustained winds around 25 to 35MPH, with gusts up to 60MPH. Those winds will be capable of bringing down trees and power lines, leading to power outages.
Also, the persistent northeast winds will pile the waters up in our coastal areas leading to some coastal flooding. Western long Island sound will likely see moderate flooding at times.
The National Weather Service says snowfall totals range from 4 inches at Ogdensburg on the Canadian border in northern New York to 12 inches in Allegany County in the Southern Tier.
The Buffalo area has received up to 11 inches from the storm that featured wind gusts of 30 mph when it hit western New York Wednesday afternoon.
The weather service says up to 16 inches could fall in some upstate areas, with 20 inches possible in higher elevations, by the time the storm begins diminishing later Thursday.
State police report about a dozen accidents on the Thruway system, none of them fatal.
The storm system has been blamed for six deaths and several injuries in the Midwest and South.
Some airlines waived change fees for people trying to change their flights to get out of New York ahead of the storm.
NJ Transit was cross-honoring tickets on trains and buses system wide from 1 p.m. on Wednesday through Thursday.
The Associated Press contributed to this report.
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Jacques Testard, co-founder of The White Review, reveals his new project, Fitzcarraldo Editions, catering for lovers of contemporary literary fiction.
YA blogger Joanne Stapley celebrates the announcement of the new YA Book Prize - and Foyles' involvement in it - and picks out some of the finest YA fiction published this year.
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Tuesday, June 29, 2010
16 comments:
- S said...
It's distressing to be in a country where the police just don't care if you are kidnapped or your apartment is broken into with the purpose of raping you.
It's also distressing that so many people in that thread immediately say, well, that's why women shouldn't drink. Lots of women here can tell you stories about being sober, conservatively dressed, walking around in broad daylight and being physically and verbally harassed by Korean men, because they know they can get away with it.
Being different in Korea is a lot like wearing a "Kick Me" sign on your back; being female just makes it worse. Even when you avoid situations that would damage your credibility, the danger is always there that some ajosshi is going to grab you on your way home or break into your apartment, and there's nothing that you can do about it except kick him in the balls and run as fast as you can.
- June 29, 2010 at 11:06 AM
- arvinsign said...
check the crime rates in other countries even from where you came from, and you will feel safer in Korea.
- June 29, 2010 at 1:04 PM
- lisag_nz said...
All due respect arvinsigm, but I find that a surprisingly lazy argument. Just because it happens in higher rates in other countries doesn't make it acceptable in Korea.
Besides, crime rates don't necessarily equate to real-life experiences, particularly when harassment, which might not reach the level of a reportable crime, is concerned.
I've lived in Korea and now live in New Orleans, which has a notoriously high crime rate. I know where I got harassed more.
- June 29, 2010 at 1:30 PM
- S said...
In Canada, I've gone to the police for help when my house was broken into, and I've called them on my neighbour when he was beating up his girlfriend. In both cases, the police responded quickly and professionally.
I'm aware that there is crime everywhere, but there is certainly more crime when there is no deterrent. The general crime rate in Korea may be low, but we're not the general population.
- June 29, 2010 at 2:08 PM
- arvinsign said...
@ liza
i agree, statistics doesn't equate to real life experiences. But personal experiences of one or 10 or a 100 people who has access to internet to tell the tales (mostly context or situation dependent) is nothing compared to a birds eye view of a country's situation as far as safety on the streets is concerned.
- June 29, 2010 at 2:09 PM
- Mike said...
I have to disagree arvinsign. Having a bird's eye view is often the best way to miss what is actually happening on the ground. Generals have no idea how many bullets are flying at their troops, even if they can tell you the number of reports of being fired on.
It's the same here. I see it DAILY. Women are grabbed, oggled, shoved, stared at, verbally assaulted... foreign women seem to be a bigger target too!
In Korea I flash my money around and walk down alleys at 4am. I'd never do those things in Chicago. But my female friends are afraid to take a bus and dine alone here, among other things, and they'd never feel that way in Chicago.
- June 29, 2010 at 2:35 PM
- arvinsign said...
Fair enough Mike. You have the point there. But maybe one point i missed emphasizing though is about the degree or gravity of crimes. Im not comparing Korea only to US or Canada, what im saying is more of a global comparison how safe it is here as compared to the rest of the world.
Talking about the numbers, yeah i heard constantly that women here are being stared at, verbally assaulted but not so much on rapes or any form of physical assault. Too many under-reported cases, yes its possible.
Im quite confident its not as high as compared to the West or worst in the Middle East and Africa. Relatively, its safe here, even for women. And i feel like some people are too much exaggerating on their description of how unsafe Korea is, or how futile the police force is in here as if they are living or came from a perfect world.
A hundred or a thousand cases of women being stared at, verbally assaulted, oggled, grabbed from behind is nothing compared to a single case of rape or rape with murder which is very common in many countries.
- June 29, 2010 at 3:11 PM
- Hbanana said...
@arvinsign--Good arguments, but I think you're missing the main point which is that the Korean police rarely give a sh** when women are assaulted, especially foreign women. It's great that Korea is *generally* safer than the world at large, but it doesn't take away from what happened in this case and in other cases (both reported and unreported).
- June 29, 2010 at 3:39 PM
- S said...
@ arvinsign
Being grabbed or yelled at is not nothing. Having less rape and murder in the streets than, for example, the Congo does not make me safe here.
I've been followed home. It's creepy and dangerous. I've had scary encounters that other Koreans noticed and ignored, leaving me trying to deal with it myself. I don't walk around my neighbourhood without my husband anymore, and I'm moving this summer to a safer apartment, but I still don't feel safe. I realize that you think I should, but that's just not my reality here, and I don't think (from your avatar) that you have first hand knowledge of being a foreign woman in Korea. I'm not sure what statistics you're looking at (I didn't find any international stats in a quick googling) but rape statistics are deeply unreliable by nature, especially in cultures that discourage reporting.
Please don't think I don't like it here. I try to balance my bad experiences with all my good experiences here and on the whole I genuinely like living and working here. I'm studying Korean and I plan to stay here for several years. I am, however, aware than I am not always safe here - and that knowledge is much better protection than thinking no harm can come to me.
- June 29, 2010 at 4:08 PM
- S said...
Ooh, statistics: http://www.nationmaster.com/graph/cri_rap_percap-crime-rapes-per-capita
According to this page, South Korea is 16th in reported rapes worldwide. (As I noted above, all rape statistics have a wide margin of error, especially in cultures that discourage reporting.)
- June 29, 2010 at 4:17 PM
- Emma said...
While the crime rates may be lower, it doesn't change the fact that rapists and the like have gotten off fairly easy in the recent past and continue on to pillage. While these are mostly just cases involving Koreans, there are cases involving foreign women as well.
As for personal experience, I've heard my friends talk about men getting off with probation for putting women in hospitals from beatings, and I myself have been attacked while walking home, oogled, told I was a 'sexual looking girl' while standing on the subway platform on my way to work (in a wool coat and baggy jeans, mind you), followed to my office (twice, two different occasions), etc.
While I can't say that the US is safer than Korea, I can say that nothing like this ever happened to me while I was living in Oklahoma or southern Florida. I suppose it depends on where you go, but definitely, Korea is not a very safe place for women, especially at night.
- June 29, 2010 at 6:25 PM
- Darth Babaganoosh said...
Stats of low crime rates don't really mean anything here when police are known for not charging people who SHOULD be charged and prosecuted.
A former co-worker had his head bashed in with a pipe in a pre-meditated attempted murder by someone he knew... police not only did nothing, they went out of their way to make sure it looked like HE was the one at fault, and made sure the hospital knew this (thereby rendering his insurance void, forcing him to pay out of pocket for the staples in his head)
Korea IS a safer country... as long as you are Korean and male.
- June 29, 2010 at 6:39 PM
- Puffin Watch said...
"check the crime rates in other countries even from where you came from, and you will feel safer in Korea."
The real meaningful comparison would be crime rates in your demographic class. For example, if you live in a city with a high murder rate but the murders are primarily drug deals shooting each other, you probably don't have to live in fear.
What's the crime rate in Seoul against young white females vs the crime rate against young white females in Toronto? Yes, we only have anecdotes. However, being white and female in Seoul makes you highly visible to predators. That tends to increase your chances of being a victim of sexual assault.
Frankly, arvisign, your statement is meaningless, as is your point.
"Korea IS a safer country... as long as you are Korean and male."
Well said.
- June 29, 2010 at 10:12 PM
- Puffin Watch said...
||According to this page, South Korea is 16th in reported rapes worldwide. (As I noted above, all rape statistics have a wide margin of error, especially in cultures that discourage reporting.)||
Indeed, S. It's a matter of definition, the willingness of victims to report it, and the willingness of cops to lay charges.
Canada is very high in those stats. Does that mean a woman is less likely to be raped in Korea? Or does that mean a woman is more likely to report her husband or a family is more likely to turn in a relative for raping a member of the family. A woman is more likely to report sexual assault by her boss at work. Etc.
- June 29, 2010 at 10:20 PM
- Brian said...
For what it's worth I always felt safer in Korea than I do/did in the US. Maybe being a white male has something to do with it, but I know that I've never been afraid to walk around large cities in Korea alone at night, whereas even in a "most-livable" city like Pittsburgh there are plenty of neighborhoods where doing so would get me robbed or killed.
That said, I've always qualified my feeling of safety with a statement like "Korea is a safe country, until something happens to you." That is, and this doesn't sound that great, you can generally have a very safe experience in Korea---male or female, Korean or foreign---but if something does happen, you have to understand nothing will come of it.
Now, we can give examples of bad policwork from all over the world, and the US is no exception. You might even put the US and South Korea on two different extremes: in South Korea the police hardly do anything, where as in the US they're pushy and obsessed with power and authority.
But, we all have stories or personal experiences to remind us that you really can't count on the police for anything in Korea. We've read in the newspapers and on blogs that this frustration isn't exclusive to foreigners. There are several examples on this blog: remember a couple years ago when a young girl was beaten by an old man in an elevator, on tape, and the police didn't move a muscle until the president of the country paid a visit?
- June 30, 2010 at 12:10 AM
- Chickjin said...
On some level, the "feeling" of safety is completely subjective. Who you think may or may not attack you can depend on your own and the surrounding area's class, race, gender, pop. density. I've always felt safe in cities- and lived in the heart of a few- Philly, Boston, and Seattle.
Some of us can't go into small towns for fear of the, "what doya think you're doing here,____(fill in racial slur)"
As was said by several posters above, you can claim Korea is safer than the U.S. or Canada, all you want, but that don't make it true for everyone, despite quoting "statistics".
Personal experience, I've been groped, grabbed, and sexually harassed more here than any other place I've lived. And not exclusively when drinking or dressing "provocatively". Stories from my peer group (expats) follow similarly, and include assault incidences.
While rape and assault statistics cannot be trusted because of various societal/familial pressures not to consider or report these incidences, we can look at other statistics to see how much women are valued, how much power they have, in our country of residence- employment statistics, for instance.
Its not a far jump to see that a society which devalues women is not "safe", either for women or children. Oh, to be born an adjossi...
- July 1, 2010 at 6:03 AM


text: Dr. Sid Hammerback (Robert Joy, left), Dr. Sheldon Hawkes (Hill Harper, center) and Det. Mac Taylor (Gary Sinise, right) investigate a twisted fairy tale when a woman in a ball gown is found at the bottom of the pond outside Belvedere Castle in Central Park. Photo: Ron P. Jaffe/CBS©2012 CBS Broadcasting, Inc. All Rights Reserved.


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Solid Plissé Bedspread
No-Iron Plissé Bedspread Offers Cool Comfort
Solid Plissé Bedspread
No-Iron Plissé Bedspread Offers Cool Comfort
Our puckered plissé bedspread is as cool and comfortable on warm nights as the one you had as a kid. Offered in colors to suit our grownup tastes, this solid bedspread coordinates perfectly with our floral plissé bedspreads. Cotton/polyester. Two bottom rounded corners. Machine wash and dry. Imported.
- Solid bedspread in lightweight, easy-care, cotton-blend plisse
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Find casual classics, like this solid bedspread in cool plissé, in our Bed and Bath department. Our lightweight plissé bedspread looks crisp and neat straight from the washer and dryer and never needs ironing.
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Alex Carrara at bar STRAF!
The atmosphere is always alive in the bar STRAF and becomes particularly compelling in the evening with our DJ sets, to appeal to a wide audience, united by a desire to hear good music in a non-pretentious location.
Alex Carrara play happy music from 19.00 to 22.00.
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They say that age is just a number, but that doesn't mean that birthdays shouldn't be special.
Whether they're turning sweet sixteen or staying stunning at seventy, we have a fantastic selection of unique birthday gifts that are designed to delight all ages.
A traditional coming-of-age, a 21st birthday is a milestone in any person's life. A celebration of all they've achieved and all that lies before them, it's only fitting that you commemorate this remarkable occasion with a truly magnificent birthday gift. We also have a brilliant choice of 18th birthday gift ideas available both for him and for her. So, whether you're preparing them for the road ahead with a thrilling driving experience or giving them a chance to relax with a pamper day, you're sure to find the perfect present to mark such a momentous occasion.
Life begins when you get past 40, so they say, so why not let them celebrate their new lease of life with a delightful day out or an unusual and unique gift? We offer a variety of marvelous ideas for 40th birthday gifts, 50th birthday gifts, 60th birthday gifts AND 70th birthday gifts, with something that is sure to surprise. From brilliant countryside breaks to fascinating steam train journeys, your loved one can celebrate in style with an exciting gift experience - the perfect way to show that you're only as old as you feel!
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Julius Randle (foot) said he will be ready for summer league in July.
The Wizards will sign Paul Pierce on a two-year, $11 million deal, according to ESPN.com.
Nerlens Noel, K.J. McDaniels (ankle) and Casper Ware will not play vs. the Jazz on Saturday.
The Rockets are still "strongly considering" matching Dallas' offer sheet on restricted free agent Chandler Parsons.
Marvin Williams agreed to terms with the Hornets on a two-year, $14 million deal.
Otto Porter was terrific in his Las Vegas Summer League debut, making 11-of-16 from the field for 25 points with seven boards, three assists, one 3-pointer and three turnovers.
Darren Collison signs three-year, $16 million deal for the mid-level exception with the Kings.
LeBron James has finalized his contract with the Cavs and it is for just two years, including an opt-out for next summer, and presumably a maximum amount of $42.1 million.
Trevor Ariza has agreed to sign with the Rockets on a four-year, $32 million deal.
Pau Gasol is finalizing a contract with the Bulls, according to ESPN.com.
Updating a previous item, the Rockets are not involved in a three-team trade centered on Pau Gasol.
The Hornets are expected to aggressively pursue free agent SG Lance Stephenson, but he's also being sought after by the Mavericks and Pacers.


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Kimberley's Q & A
Who's your favorite sports team, and why?
I Love my hometown baseball team the Rays!!
What's your favorite video game, and could you kick our butts at it?
I played Super Mario when I was younger! I could pick right back up where I left off!
Piercings/Tattoos (How many? Where?)
My ears and my belly button
What's your best party trick?
A Champagne Glass Fountain! It's great if you want to poor everyone a glass at the same time!
What's the worst job you've ever had?
I Haven't really had a bad Job! They have all been Pretty Fun!
What's the most dangerous thing you've ever done?
It definitely would be cliff jumping in Jamaica from 40ft up! What a rush!
It's 4AM after a crazy night out – what are we eating?
Pizza or Finding a 24hour Breakfast place! Nothing like early breakfast after a fun night!
What's the naughtiest thing you've ever done in public?
Hmm. I think that one should stay a secret....
What do you feel sexiest wearing?
A T-shirt and boy shorts! Nothing like being comfortable!


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-Dan Thomas, CEO and Founder
We take pride in offering no hassle returns. In the event of a return, please call, email or chat with us to receive a solution to the problem. For apparel that doesn't fit quite right, Click here to see our Fit Guaranteed Program.
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Comments On Jul 08, 2014:This item has saved my knees and shins some many times!! Way cheaper than going to hospital.
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Comments On May 12, 2014:These knee guards are on par with the standard knee guards supplied with mx pants. If you require a brace or extensive protection look else where.
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Comments On Apr 17, 2014:Good knee guard for trail riding, however they are MUCH larger than they appear in the photo. The Knee Cup is HUGE. The Venting is very nice, gave 4-stars only because they will not fit in some of my pants.
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Comments On Mar 26, 2014:These are great. One star for how they don't pinch the back of my knee, because they strap around your shin. Another star for the full protection One for the price and 2 for RM I'd buy them again but I only got 2 legs.
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Comments On Mar 05, 2014:Excellent price excellent product
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Comments On Feb 23, 2014:for the money, these are a good back up and work as expected.
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Comments On Jan 11, 2014:I've had these for a few years now and they still feel great, besides the fact that they have saved my knees from rocks and trees quite a few times!
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Comments On Dec 31, 2013:Excellent value... low priced and a good product
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Comments On Dec 07, 2013:Product worked as intended. Would buy again. Nothing ground breaking here.
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Comments On Sep 23, 2013:Fell apart already only road 3 times with them, Buy something better.
Additional Comments On Sep 23, 2013:Right side fell apart called rockymountain, they replaced the set without any issue, hopfully the old set was just defective, however this is why I like this web site because customer service is awesome!
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Other items of interest


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Thief 4 Officially AnnouncedAs expected, Deus Ex 3 developer Eidos Montreal today announced its second title, Thief 4, referring to the oft-rumored project as "the worst kept secret in the industry."
Few details on the stealth-action sequel were given--no word on specific platforms or a release estimate--with Eidos Montreal general manager Stephane D'Astous stating that it is "in the early development stages."
While today's announcement referred to the title as "Thief 4," the game's official website uses the "THI4F" graphic displayed above.
"It's too early for us to offer any specific game details, right now we are focused on recruiting the very best talent to join the core team at the studio and help us make what we believe will be one of the most exciting games on the market," D'Astous continued.
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text:
Mohair, Joni Mitchell, Kate Moss, collage on a photo from Pop, Marc Jacobs FW10, vintage JPG ad, cat, Sam Falls.
And a repost of a collage I made in the summer while desperately wanting winter (credits here.)
nice.. the first sweater is amazing ;)
like the colored sweater^^
ahahha cute kitten!
Great collage, and aha, check out that awesome kitty :D
Day By Diva
Day By Diva
Day By Diva
The JPG ads were fantastic! Some of my favourites.
Also Christmas jumpers! Classic.
Pretty Much Penniless
Nice work!
Oh, hello, Tavi. I gotta say you are incredible, amazing, awesome... Wow.
Can I ask something? Do you make the collages on your own? And, you make them on PC or just on a paper?
Hoping your anwser
Love: Raquel
Love the collage, and the first jumper is UH-MAZING x
Ah, tis that sweatery time of year again.
i'm in love with that mohair sweater, perfect!
and the young and stunning kate moss.
Sweet! Grace Coddington, I just love her.
Tavi, you're on vacation already? Lucky duck! I don't get out till Christmas Eve. That Sam Falls sweater is amazing. I think ima need to take an embroidery needle to one of my preexisting sweaters now.
"Boys don't make passes at girl who wear glasses" = genius.
sweater weather is the BEST. have you seen this tumblr? it's awesome.
Love that sweeater it looks great!
Snow came early and I am already in my winter woollies. I'm also on my winter break and definitely feeling those christmas vibes.
I Want A Thick Black & White Jumper This Seaaason, Or Something Khakhi/Grey.
mm everything looks so snuggly! And I know how you feel about winter break...desperately needed these two weeks of chillin'
I'm loving the Nordic knits right now. They'll never be out of style. Give me a Norway sweater, or a classic Aran knit, and I'm a happy, warm girl.
winter break is definitely a bliss! i love the sweater in the first picture
love the post
Le Kiss Kiss-Click Here!
Fantastic inspirational photographs! Especially the collage! Love it!
nice things ... ;)
yay to winter and the ability to layer.
kate moss looks so little.
that first sweater is killing Me.
Tavi Dear,
a HELOOOO from.......... BRASIL!!
I loved this Winter Post (you know: here in Brasil it is Spring, almost Summer. So hot!)
Girl: you have a great taste for puting things together. A natural and personal talent OR have you followed the steps of someone special in your family??
For example: I love to write and I've got this insane and sweet inclination from my Grampa.
Stay in the Peace of God!!
You, Your Family and All Your Fans!!
I sure do love a good sweater/jumper
I'm loving the "boys don't make passes at girls who wear glasses" quote on the collage. Brilliant!!
Nice choices... The collage that you did is amazing... Love the Grace Coddington photo in it.
wow i've never seen that joni picture before, thank you for sharing this! xxxx
Yay for winter break! tee hee i like the cat in the sweater :)
I really adore the collage :) Nice work!
What a great collage!
And the sweater is amazing!
Start dreaming on www.dreamingthedayawaywithluca.blogspot.com
Sweet jesus, Tavi, that sweater is amazing. Now I want it. And every single other one on the blog. They are like the northern lights in sweater form; pure magic. Also, the writing on that blog is how I wish everyone talked all the time.
sam falls is the shit!
Love that little cat.
Can't wait to see what you pull together.
the first sweater is great, and I love the last collage :)
I saw someone wearing a Coogi sweater last week!
love the colours of the first sweater and the texture too. it looks like mohair
Is Grace Coddington talking on her cat-phone?
And for some reason that "Gee, Thanks" reminds me of Andy Warhol :-)
I miss having winter break, I loved it when I was in school.
My Heart Blogged
Hey Tavi,
Love you blog. I just started one and I think you would really like it. Please if you can, tell me what you think. I think everyone try to be relevant but I am really trying to. www.thingsbecomthings.blogspot.com
Have a good holiday
Oh GAWSH, I adore you and your sweaters. My momma just finished knitting me a very special sweater, purple-y blue with a little orange...
I'm obsessed with the recycled looking sweaters, such interesting shapes!
Once you start high school is the moment you realize the reason there are break. So dang stressful.
Ps my dadbowned a few Cosby-isque sweaters. Beat things in the world.
I'm so with you on the winter break bit. Everyone, let's do whatever the f*ck we want, yay!
love the collage...
Sweater is always gonna be my Favorite. the first sweater picture, is that yours?
visit my Blog : www.nowluthfisturn.blogspot.com
Ugh, 3 more days of sleepless studying for me... but the picture with the scribbled-out faces? Fantastic. Particularly that neon-yellow shirt...
Do you ever feel like a Twiggy? Or do you feel like you were born in the wrong decade because seriously you are truly a 70's girl.
Great post! Definitely a little more stylish than a Cosby sweater, love the reference LOL. Cute kitten!
That bird sweater! I NEED that bird sweater!!
In the early 90s, Bjork would crop her sweaters to be above the navel, and layer them over maxi dresses.
This trend is overdue for a comeback.
*stares in Tavi's direction*
your post is always great! and also for this one:D i really love the soft feeling of the colorful sweater and pictures!!!♡
Loving the scrapbookie thing, the colours are fab!
love this your handwriting is adorable :]
I love your collage, winter is so much fun!
xoxo Sootjeelina <3
AAAH, if only my country has four season! I should have a collection of a sweet sweater.. always love your random thought.
All those sweaters in the picture in the second row on the right are amazing. I want them xxx
hi Tavi!love the collage.and Grace Coddington,i love her<3
Voilà un petit mot pour dire que j'adore ton blog, il est magnifique et respire ta personnalité !!!
J'aime beaucoup la photo en noire et blanc de Grace Goddington !!!
Viens faire un tour sur mon blog
Would you like to do my survey, to help my blog get further?
would love your help and support!
such a statement for fall.
My favorite is the cerulean from prada, the one Anne is wearing on the movie, and the one from the last collection!
Exactly the same!
i love the second photo! i love you tavi! kisses from spain
since u're lovin the cosby sweater thing, I think you'll be interested in this post on cosby sweaters and some findings on Etsy
Yay winter break! I was excited about sweaters and furry hats..but silly Texas wants it to be in the 70's this week..oh but it'll dip down to 49 on Christmas! Brr! Pshnot..I'm from St. Louis..I miss the snow! Um but I digress..
Sweaters are awesome :] I've been stalking Urban Outfitters like everyday since October for sweaters :O Great post!
-Bailey Faye, To The 9's
the marc jacobs look is so beautiful
Wow, I love Kate Moss. She was kind of an idol when I was in my teens, I wanted to be as thin as her. I guess I succeeded...
* Adorable gray tabby by the way!
a big YUM for wooly cosy jumpers xx
Love the photos, very inspiring post love. xx
lilyfm said...
love this your handwriting is adorable :]
See!!!! ;-))
I just finished writing one of the longest and best post I have ever written befor. Sweaters are my favorite Clothing peices ever! I need to get more. Maybe a goodwill sweater shopping spree is in my futcher?
Aww, I don't like the quote "boys don't make passes at girls who wear glasses." I wear glasses. T^T
I like the coat in the collage though! ^^
mmm, sweaters. I'm partial to oversized men's sweaters, either thrifted or hand-me-down. And your post awhile back on Black Swan was great. I saw the movie and was so creeped out and tense the whole time but it was SO GOOD.
You're awesome :-)
Love the collage.
Since you're so tiny, you could get some large vintage wool sweaters and wash them in hot water for a boiled sweater look... Even if they have holes, cause they should shrink right up!
thats one cosy looking sweater.
Ice Castles 1978
galaxie !
Sweaters are the lifeblood that fuels the dreams of champions.
Especially when said champion gets hugs all day because their "sweater looks cozy."
Sweter is amazing .
And .. Kate <3
the collage you made is amazing. so inspirational!
Boys love girls who wear glasses, let me tell you...
And mhm mhm cosby sweaters!
Thanks for the very nice post. All the outfits are amazing. The use of colour is really great.


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Six schools sit within a quarter-mile radius of 66 Park Avenue in Brooklyn. Shortly before 2 p.m. Tuesday, Fox 5 -- with the aid of a speed gun -- witnessed vehicles passing that address at speeds 15, 16 and 17 mph faster than the legal limit.
"In order to save lives we should be paying closer attention to our speedometers," said Juan Martinez, the general counsel for Transportation Alternatives, which has advocated for speed cameras on New York City streets for the past decade. That crusade is set to finally come to an end, thanks to new legislation later this year.
"It would be wonderful if we never ticketed anyone," Mayor Michael Bloomberg said at a news conference Tuesday. "And in that sense, the speed cameras will have paid for themselves, maybe not in dollars but in lives saved."
The city plans to install 20 cameras, all near schools. Radar will track speed, lenses will capture license plates, and $50 tickets will punish offenders.
"Too many drivers try to pull a fast one on streets near New York City schools," Transportation Commissioner Janette Sadik-Khan said.
According to the mayor's office, even driving 40 mph instead of the posted 30 mph lowers a child's chance of survival if struck by 50 percent.
The speed limit on Park Avenue in Brooklyn is 30 mph. But in just 10 minutes on Tuesday afternoon, Fox 5 recorded speeds of 43, 40 and 47 mph.
"You can't put speed bumps on this avenue," Martinez said. "You can't narrow this street."
But now the city can install those speed cameras and then move them around as it sees fit, in hopes of deterring would-be speeders no matter where they're driving.
"[Drivers] have to assume there's a camera there," Bloomberg said.
New York City traffic fatalities reached all-time lows in the last five years, but speeding still remains the single greatest factor in traffic deaths.
State lawmakers have passed a bill allowing cameras near 20 city schools with documented speeding issues.
Speeding is cited as the single greatest contributing factor in city traffic fatalities.
The bill authorizes $50 fines for "dangerous"speeding along with existing red-light cameras and continuing aggressive enforcement of traffic laws, will help maintain the record traffic safety gains in the city.
"Over the past decade, traffic fatalities in New York City have fallen by more than 30 percent, reaching all-time record lows," said Mayor Michael Bloomberg. "But speeding remains the single greatest contributing factor in traffic fatalities in New York City."
New York City has recorded historic low traffic fatalities in the last five years and has fatality rates less than one-third of the national average and half that of other big cities, but speeding remains the greatest single factor in traffic deaths, contributing to 81 fatal traffic crashes in 2012 -- approximately 30 percent of all traffic fatalities.
The city is currently authorized to use re-light cameras at 150 locations.


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find a physician
Whether you need a new physician or you want more information on a recommended or current physician, St. Francis can help. Fill in information or select from the search fields below to discover the physician that is right for you. Note: you do not have to complete all fields to return search results.


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If you have any feedback or suggestions for our Editorial Team, please contact us at Editorial
Posted by yaz 1 year ago
Top Response
Posted by yaz
1 year ago
"Strong info. Love the perspective on new coach's."
"The Real Deal" Bryan Power is on an UNBELIEVABLE 25-6 MLB Run, including 6-1 his last 7! Overall, he's gone 50-25 (+$19,000) L20 days! It was a 2-0 Thursday Football SWEEP last week! What are you waiting for? The time to subscribe is NOW!
1* Georgia Tech: There's been a change in favorite here, and I'm not sure I understand why. It probably has something to do w/ the fact that Georgia Tech is 0-5 both SU and ATS its last five meetings vs. Miami, but the Yellow Jackets come into this year's matchup as the better team and w/ the homefield advantage. Clearly, others are putting more stock in the 'Canes' 22-10 win over Duke than I am.
Two years ago, as a 13-point dog, Miami trailed Georgia Tech 36-19 here in Atlanta before rallying for an overtime win. "The U" has not made significant strides since then, so the wild swing in the line is not justified in my opinion. In fact, I would argue that Miami is as overrated as any program in the country. The whole "The U is back" narrative is played out almost every year as Florida State has clearly surpassed them in terms of recruiting and being the "glamour" program in the state. The team has lost both of its road games so far, at Louisville and Nebraska, two programs fairly comparable in overall skill level to Georgia Tech. Thus, I don't understand why bettors are now willing to lay points with the Hurricanes.
Georgia Tech is unbeaten at 4-0 and off a bye week, which is another advantage for them. In their last game, they beat Virginia Tech 27-24 as eight-point underdogs. Look for them to have tremendous success running the ball here against a Miami defense that was gashed for 343 yards over land by Nebraska two weeks ago. Thanks to Paul Johnson's triple option offense, the Yellow Jackets come in averaging almost 300 YPG on the ground. Take the points. 1* Georgia Tech.
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Oceana's executive chef Ben Pollinger, shows you how to cook salmon to perfection from his new book 'School of Fish'. Learn how to sear salmon.
Oceana's executive chef Ben Pollinger, shows you how to properly crack lobster, from his new book 'School of Fish'.
Chef Pedro Rodriguez of the New York City Rescue Mission shares his top cutting tips.
If you're trashing the peel of your oranges, you're missing out on the opportunity to make candied orange peels.
Boxed wines get a bad rap. Franzia, Paper Boy Winery, and Black Box boxed wine are reviewed by The Savory's Ross Gardiner. Does he like them? Thumbs up or down? Watch and see.


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So you have your suitcases laid out for everyone in the family, now the question is what to bring? You already know that your whole house won't fit in the car. But no need to worry, follow these helpful hints and packing should be a breeze.
Stay organized, lists are a perfect way to keep control. Keep lists for each member of the family, this will prevent any confusion in what you have packed and what you need to pack.
For the Children:
You may think that you need everything but if you are really crunched for space, don't pack anything that you can buy at your destination. Maybe you really don't need that 100 pack of diapers, 24 might suffice for the beginning of your travel.
Before You Go > Packing for Children > First Aid & Emergency Numbers
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text:
Pamela's Q & A
If you could do a shot of Jose Cuervo with anyone -- dead or alive -- who would it be?
Jimmy Buffet
Favorite Sport/Team
Alabama Crimson Tide
Favorite Movie/Actor
Office Space
Go-to karaoke song
Don't Speak- Gwen Stefani
My first job
Piercings/Tattoos (How many? Where?)
Mac or PC?
Nintendo, Xbox 360, PS3, or don't game?
don't game
What fun fact, talent or superpower of yours should guys know about?
I was voted "Most Talented" in highschool.
What's the most memorable pick up line you've ever heard?
How about when you get off of work, I take you to the bar & we can finish this conversation.
What's the craziest thing you've ever done?
Believe it or not, a hot girl drugged me. Next thing you know, I Woke up on a bed of hot girls and the rest is history.
What's the most unusual place you've ever hooked up? How'd it go?
On a church trip, in the middle of the woods. Yes, one of the bible study women saw & no words were ever said, but it was mind boggling.
What's in your purse or pocket right now?
A million lipglosses, money, cell phone, gum, candy
What do you feel most comfortable wearing?
short shorts or skirts. I have amazing legs!
Would you rather have boring sex all the time or an amazing romp once a year?
Probably boring sex because I can get off in other ways when I have "me" time.
What is your Axe personality?
Without a shadow of doubt, most definitely the party girl one! I have this wild side to me that I just can't escape no matter how hard I try! I truly will be a good girl for as long as I possibly can stand. I seem to acquire many hot girl phone numbers thinking I made yet another best friend. Of course this never turns out good because my real friends are super annoyed when we end up with tag-a-longs. Did I mention there is nothing that is going to get me off that dance floor?!?! Sorry DJ, but the dreadful slow song you are playing at closing time doesn't work on me! Oh, and thank you boyfriend for dealing with me again. I know it was soooo worth it :).


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This stylish petticoat is made of peach coloured rayon, an artificial silk which first became popular for underwear and dresses in the 1920s, and which was a cheaper alternative for more luxury fabrics. However, rayon was also used for expensive lingerie such as this slip, retailed by the department store, Bourne & Hollingworth Ltd, on Oxford Street in London, or by D H Evans, as in the advertisement below, where an art silk slip cost 9 shillings and 11 pence, and a silk one 15 shillings and 11 pence.
The fawn lace, which trims the neckline, is designed with a pattern of concentric semi-circles, influenced by the Art Deco style promoting the "moderne" fashion for geometric, angular and dramatic shapes and colours. This petticoat combines the twin novelties of the newly available rayon with the deco geometric decoration, and it would have been absolutely up-to-the-minute in fashionable terms, very different to the heavy white cotton underwear worn by most women previous to the First World War.
Full item descriptions:
"petticoat" [1957.142], Bourne & Hollingsworth Ltd
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YPSILANTI, Mich. (WJBK) -- The Ypsilanti police department is asking for information following the death of Demarius Reed, a well known player on the Eastern Michigan University football team.
According to the university's website, investigators are looking for anyone who attended the 'after party' on the night of October 17th, through the morning of October 18th. The party was held at 773 Green Road, Apartment 104 in Ypsilanti in the University Green Apartment complex.
Anyone with information is asked to call Ypsilanti police detectives at 734-368-8780 or the information tipline at 734-483-9510.
Demarius Reed was discovered around 7:15 a.m. in an off-campus apartment in the 700 block of West Clark Road. Ypsilanti Police tell the Ann Arbor News the victim was discovered by his roommate and appeared to have been shot to death.
An auditorium at EMU was filled Friday afternoon during a question-and-answer session with faculty, staff and university police.The circumstances leading up to the suspected homicide were not made available. However, the university's chief of police, Bob Heighes, told students that police have suggested a possible motive for the crime may have been robbery.Reed, a junior wide receiver from Chicago, had 15 catches for 185 yards and a touchdown in six games this season.
In what some are calling a "haunting tweet," Reed tweeted out on Tuesday: "Blessed ta see another 24 [hours] please help me to make good decisions my lord". (See right.)Reed was taken out of a football game last week after sustaining a blow to the head that caused a concussion. "I loved him. Demarius was my best friend, and he was my son at the same time. It's really unfortunate what's happened. I'm honestly at a loss for words right now. I'm hurt, but, I loved him and I appreciate him. I appreciate the time we have together," his father, Carl Reed, says. In addition to the Ypsilanti police department anyone with information may call Crime Stoppers at 1-800-SPEAK-UP.
The Associated Press contributed to this report.
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Study: Inhaling Auto Emissions Turns Good Cholesterol Bad
A new study suggests that inhaling motor vehicle emissions is bad for a person's cholesterol. Researchers at the University of Washington and UCLA say it may transform good, protective cholesterol into a bad, artery-clogging kind. That increases the risk of heart disease and stroke. The study adds to a field of evidence linking air pollution with heart disease. Researchers used mice to come up with their findings. They say further study in humans will be required in the future.


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A necropsy and rabies testing are being performed on a bobcat after the animal was seen acting aggressively near the site of an attack in Show Low.
A woman was scratched and bitten on her thigh by a bobcat Sunday at about 10:30 p.m. behind a Lowe's store, the Arizona Game and Fish Department said in a press release.
She was given rabies vaccines and anti-rabies serum as a precaution. A bobcat was spotted nearby by a Navajo County deputy sheriff, who killed it.
"Bobcats rarely attack people, but when they do, the animal is often rabid," said Bruce Sitko, department spokesman. "While we don't expect a larger outbreak of the virus in the local area, we want to err on the side of caution in alerting residents to watch and report any abnormal behaviors in other wild or domestic animals, as this bobcat may have had contact with them."
Rabies is a viral disease that attacks the central nervous system and is always fatal once symptoms appear. The virus can be transmitted to people or animals through bites from infected animals or exposure to infected saliva through open wounds or mucous membranes, the department said.
The department said the last case of a bobcat testing positive for rabies anywhere in Arizona was a single incident in 2011.
Health Services and department officials recommend the following to protect individuals and pets from rabies:
Copyright 2013 Associated Press. All rights reserved. CBS 5 (KPHO Broadcasting Corporation) contributed to this report.
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Currently discussing Cutting Through Spiritual Materialsm by Chögyam Trungpa Rimpoche
Free open house where new students can receive meditation instruction. Sitting meditation begins at 7 o'clock. Snacks, book study and discussion begin at 8 o'clock.
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For more details or if you have questions, please contact Scott Kamilar at firstname.lastname@example.com
Chögyam Trungpa Rimpoche (1939-1987)—meditation master, scholar, and artist—was the founder of Shambhala. After escaping the Chinese invasion of Tibet, he came to the west to teach Shambhala Buddhism. This book is a collection of some of his most important and influential teachings.
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Tanning Study Suggests Strategies for Preventing Skin Cancer
Researchers have identified a drug that bypasses a genetic predisposition and induces tanning in mice prone to sunburns and skin cancer. The result is "sunless" tanning that offers mice some protection against skin damage from ultraviolet (UV) light.
The drug, called forskolin, supplies a signal that's weak or missing in the skin cells of fair-skinned mice. Without this signal, the cells make red or blond pigment rather than brown or black.
By rubbing forskolin cream on fair-skinned mice once a day for several weeks, researchers at the Dana-Farber Cancer Institute caused the mice to produce dark pigment that was largely indistinguishable from that of brown or black mice. Read more
Guest Update by Dr. James Doroshow
Workshop Helps RAID Program Adapt, Evolve
Launched in 1998, NCI's Rapid Access to Intervention Development (RAID) program has become an important resource for investigators engaged in anticancer therapeutics development. In July 2005, a workshop was held to comprehensively review the RAID program, and determine ways to improve its effectiveness and overall operation.
The report from that workshop - which was chaired by Dr. John Mendelsohn of the University of Texas M.D. Anderson Cancer Center, and involved experts in cancer research and drug development from the country's top academic centers and industry - includes important recommendations that should greatly strengthen NCI's drug development capabilities.
As Dr. Niederhuber explained earlier this year in the NCI Cancer Bulletin, RAID provides a bridge between discovery and the introduction of an agent into phase 0 or phase I human clinical trials by offering invaluable support - including bulk drug production, formulation, pharmacokinetics, and toxicity testing, among others - to principal investigators (PIs) working on the development of small-molecule drugs and biologics. Read more
Tanning Study Suggests Strategies for Preventing Skin Cancer
Researchers have identified a drug that bypasses a genetic predisposition and induces tanning in mice prone to sunburns and skin cancer. The result is "sunless" tanning that offers mice some protection against skin damage from ultraviolet (UV) light.
The drug, called forskolin, supplies a signal that's weak or missing in the skin cells of fair-skinned mice. Without this signal, the cells make red or blond pigment rather than brown or black.
By rubbing forskolin cream on fair-skinned mice once a day for several weeks, researchers at the Dana-Farber Cancer Institute caused the mice to produce dark pigment that was largely indistinguishable from that of brown or black mice.
The forskolin-induced tans offered protection against UV rays, even among mice predisposed to develop skin cancer, the researchers reported in the September 21 Nature.
"Many mice still got tumors, but darkening their skin significantly delayed the tumors and reduced their number," says Dr. David Fisher, who directs Dana-Farber's Melanoma Program and led the study.
The work was done completely in mice, Dr. Fisher adds, and more research is needed to understand the tanning "pathway" in humans and to assess potential treatments.
"The importance of this study is to show that you may be able to bypass genetic deficiencies in tanning that exist in people through topical agents," says Dr. Glenn Merlino, chief of Laboratory of Cell Regulation and Carcinogenesis in NCI's Center for Cancer Research (CCR), and a melanoma researcher.
"This study provides proof of principle that this concept could work, and its application to humans will depend on safety and other factors," adds Dr. Merlino.
Dr. Fisher's team began by characterizing the tanning pathway in mice. They reasoned that the pathways are similar in light- and dark-skinned mice except for a single protein, the melanocortin 1 receptor.
When dark-skinned mice are exposed to UV light, the melanocortin 1 receptors produce a strong signal that activates the chemical cAMP. This is essential for producing dark pigment.
But under the same conditions, the melanocortin 1 receptors of fair-skinned mice do not generate a strong signal. To bypass this "block" in the tanning pathway, the researchers gave the mice forskolin, one of several drugs that activates cAMP.
Forskolin effectively introduced a tanning response in mice that had never had one.
The melanocortin 1 receptor functions differently in light-skinned mice compared with other mice because of an alteration in the melanocortin 1 receptor (mc1r) gene.
Many fair-skinned people, particularly redheads, have inherited this variant gene, and the gene is associated with an increased risk of UV-induced skin cancers.
For people who live in Nordic regions with limited sunlight, a tanning response may block out UV rays that are needed to help process Vitamin D, leading to a deficiency or even death, notes Dr. Fisher.
But in sunny climates, tanning evolved as a response to UV light. "Tanning prepares the body for more UV exposure and protects against damage," says first author Dr. John D'Orazio, who is now at the University of Kentucky.
Forskolin protected mice against a form of squamous cell carcinoma, the most common skin cancer in humans. The researchers will investigate whether it protects against melanoma, an aggressive and often deadly skin cancer that is increasing in incidence worldwide."I think this research is a great example of how mouse models can be successfully used to gain novel insights into human disease and its prevention," says Dr. Merlino.
By Edward R. Winstead
Guest Update by Dr. James Doroshow
Workshop Helps RAID Program Adapt, Evolve
Launched in 1998, NCI's Rapid Access to Intervention Development (RAID) program has become an important resource for investigators engaged in anticancer therapeutics development. In July 2005, a workshop was held to comprehensively review the RAID program, and determine ways to improve its effectiveness and overall operation.
The report from that workshop - which was chaired by Dr. John Mendelsohn of the University of Texas M.D. Anderson Cancer Center, and involved experts in cancer research and drug development from the country's top academic centers and industry - includes important recommendations that should greatly strengthen NCI's drug development capabilities.
As Dr. Niederhuber explained earlier this year in the NCI Cancer Bulletin, RAID provides a bridge between discovery and the introduction of an agent into phase 0 or phase I human clinical trials by offering invaluable support - including bulk drug production, formulation, pharmacokinetics, and toxicity testing, among others - to principal investigators (PIs) working on the development of small-molecule drugs and biologics.
While drug company scientists have such services at their disposal, many academic researchers do not, so RAID offers access to crucial drug development resources to the research community. In addition, RAID fills an important niche because it supports PIs who are working on rare diseases and pediatric malignancies, and attempting to validate new therapeutic targets.
Overall, the recommendations from this new report call for NCI to actively monitor individual project milestones and achievement of timelines, and to intercede with changes or "go/no-go" decisions. This will ensure that RAID resources are being used in the most efficient manner possible.
NCI will immediately begin to implement a recommendation for the establishment of a two-tiered review system to optimize the prioritization and use of RAID resources. This will entail the creation of a standing committee of extramural experts to oversee the overall operation and function of the RAID program - the RAID Oversight Committee - and two subcommittees, one for biologics and one for small molecules, to aid in the review of specific applications, feasibility, and project management plans.
In response to another recommendation, NCI will also establish teams to advance RAID-approved projects. Project managers with expertise in both science and managing therapeutic development teams will work with PIs and NCI staff to formulate and implement comprehensive development plans for the RAID agents, including timelines, milestones, and resource requirements.
Other changes that will be made in response to this report include:
A number of other changes to the RAID program also will be implemented over the coming year. Our goal is to ensure that we are getting the maximum return on our investment.
As some of the exciting results from early-stage trials involving RAID-supported agents suggest, this program has the potential to make a substantial difference in the lives of many patients. We believe the reviewers' recommendations will make the RAID program stronger and lead to many new effective cancer treatments.
Common Prostate Cancer Treatment May Increase Diabetes Risk
Even for just a few months, the use of androgen deprivation therapy to treat men with prostate cancer that hasn't metastasized may significantly increase the risk of diabetes and cardiac-related effects, including heart attack, according to a study in the September 20 Journal of Clinical Oncology (JCO).
Conducted by Dr. Nancy L. Keating and colleagues of Harvard Medical School and Brigham and Women's Hospital, the observational study followed more than 73,000 men 66 years of age or older who were diagnosed with locoregional prostate cancer between 1992 and 1999. More than one-third of the men in the study received a gonadotropin-releasing hormone (GnRH) agonist, while approximately 7 percent of the men underwent a complete orchiectomy (surgical removal of the testicles).
GnRH agonist use was associated with a 44-percent increased risk of patients developing diabetes, with smaller - yet still statistically significant - increases in the risk of heart attack, coronary heart disease, and sudden cardiac death. Although diabetes risk also was significantly increased with orchiectomy, it did not appear to have the same cardiac effects. Because so few men underwent this procedure, the authors cautioned, the study may have been underpowered to detect such a risk.
The increased diabetes and cardiac risks associated with GnRH agonist use appeared as early as 1 to 4 months after treatment initiation.
"Our findings suggest that, for men who require GnRH agonist therapy, strategies to mitigate modifiable risk factors for diabetes and coronary heart disease may be warranted," they concluded.
Dr. Lori Minasian of NCI's Division of Cancer Prevention (DCP) cautioned that the study may have been unable to account for preexisting comorbidities in the study population. "So it's too soon to say from this study alone that there is a clear increase in risk," she said.
Gemcitabine Plus Carboplatin Benefits Women with Recurrent Ovarian Cancer
A phase III randomized trial has shown a statistically significant improvement in progression-free survival for women with platinum-sensitive recurrent ovarian cancer given gemcitabine with carboplatin compared with carboplatin alone, without any significant differences in quality of life. The results, published early online September 18 in JCO, come from an international collaborative trial comprising investigators from Europe, Canada, and the United States.
Investigators randomly assigned 356 women with recurrent ovarian cancer whose tumors had previously responded to first-line therapy with a platinum-based regimen to receive either carboplatin alone or carboplatin plus gemcitabine, and compared progression-free survival, side effects, and overall quality of life.
Though more high-grade hematologic side effects and a greater incidence of alopecia (hair loss) were seen in patients taking carboplatin and gemcitabine, few patients in either arm discontinued treatment. The median progression-free survival was 8.6 months for patients taking carboplatin and gemcitabine, and 5.8 months for patients taking carboplatin alone. The benefit provided by the addition of gemcitabine persisted even after adjusting the data for other factors that could affect progression-free survival. Quality-of-life questionnaires showed no statistically significant differences between the two groups of patients.
"Gemcitabine plus carboplatin represents a new treatment option for patients with platinum-sensitive recurrent ovarian cancer," stated the authors. Such new therapeutic regimens are badly needed, they explained, because cumulative neurotoxicity limits the reuse of taxane and platinum combinations often used as first-line therapy in the disease.
Advanced Cancer Patients Benefit More from Aromatase Inhibitors than Tamoxifen
Aromatase inhibitors (AIs) have proven superior to tamoxifen as a hormonal treatment for early-stage breast cancer in women with estrogen-sensitive tumors. The third generation of these agents - letrozole, anastrozole, and exemestane - is also widely used to treat advanced or metastatic breast cancer, though clinical results about their value in that setting have been mixed. Researchers from Greece analyzed published trials and found that third-generation AIs provide a definite, if small, overall survival advantage.
"Our results may represent a departure from the standard management of advanced breast cancer with hormonal therapy that has been used for the last two decades," wrote Dr. John P.A. Ioannidis of the University of Ioannina School of Medicine and colleagues in the September 20 Journal of the National Cancer Institute (JNCI). "The standard of care may need to be reconsidered."
The AIs reduced the risk of death by 13 percent - about 5 months more life in women whose median survival is projected to be 40 months. Though they may produce more hot flashes, the AIs are generally more tolerable than tamoxifen and also improve quality of life.
In an accompanying editorial, Drs. Catherine H. Van Poznak and Daniel F. Hayes of the University of Michigan agree that AIs are the drug of choice for women with endocrine-responsive metastatic breast cancer, without ruling out some use of tamoxifen. They cite surveys of oncology practice patterns which show that only about half of these women will receive AIs as adjuvant therapy, despite a recent recommendation by the American Society of Clinical Oncology (ASCO).
Rising Kidney Cancer Mortality Challenges Treatment Standards
Although rates of surgery for renal cancer have increased with the rising incidence of this malignancy over the last 20 years, a new study published in the September 20 JNCI suggests that a corresponding increase in survival has not been realized.
Investigators from the University of Michigan collected data from 34,503 patients with kidney cancer recorded in the Surveillance, Epidemiology, and End Results (SEER) registries from 1983 to 2002, and compared yearly incidence of the disease, incidence of renal surgery, pretreatment tumor size, and demographic data.
Their results showed an increase in the incidence of kidney cancer from 7.1 per 100,000 U.S. population to 10.8 per 100,000 - an increase of 52 percent. This was attributed largely to an increase in small (≤4 cm) renal tumors, which are now often found incidentally during newer, more powerful diagnostic procedures for other conditions. "This increase in incidence of the small renal mass has been paralleled by an increase in surgical treatment," explained the authors. However, despite the increased incidence of surgery, kidney-cancer-specific and overall mortality for patients still rose by 155 percent and 323 percent, respectively.
"Despite increased detection and treatment of small masses, mortality rates for kidney cancer have continued to rise. Collectively, these trends raise questions about the effectiveness of the current treatment paradigm for kidney cancer," stated the authors. They suggest that a proportion of small kidney tumors may be a more indolent form of renal cell carcinoma that "may not merit surgical removal."
Age Associated with Type of Breast Cancer Treatment
Women 75 or older with early-stage breast cancer are more likely to receive nonstandard primary tumor therapy in an integrated health care setting, reported a study in the September 18 JCO.
Dr. Rebecca Silliman of Boston University Medical Center and colleagues identified 1,859 women 65 years of age or older with stage I and II breast cancer between 1990 and 1994 from 6 geographically diverse integrated health systems of the Cancer Research Network. Using SEER cancer registries, as well as clinical and administrative databases, researchers collected data on demographics, tumor characteristics, breast cancer treatment, and comorbid conditions prior to diagnosis.
Researchers then compared women who received standard primary tumor therapy, defined as axillary lymph node dissection and radiation therapy after breast-conserving surgery (BCS), with women who received nonstandard primary tumor therapy. They also compared women who received a tamoxifen prescription or chemotherapy with women who did not.
Women with higher comorbidity index scores, and women 75 or older, were more likely to receive nonstandard primary tumor therapy. While risk of recurrence was also associated with receipt of nonstandard primary tumor therapy, no link exists for standard primary tumor therapy. Additionally, researchers found that African American women were less likely to be prescribed tamoxifen and Asian women were more likely to undergo BCS than were white women.
The study's authors concluded that "Age is an independent risk factor for nonreceipt of effective therapies, even when comorbidity and risk of recurrence are considered."An accompanying editorial by Dr. Jeanne Mandelblatt of the Lombardi Comprehensive Cancer Center in Washington, D.C., noted that, "What we need is an understanding of the biology of cancer in this population [women 65 or older with breast cancer], tools that can help clinicians identify physiological reserve and ability to withstand the rigors of more aggressive treatment, and more consistent elicitation of women's informed preferences."
Combining Targeted Therapies for Thoracic Cancers
Name of the Trial
Principal Investigators
Why This Trial Is Important
The drug flavopiridol has been shown to have a weak anticancer effect. However, when administered to cancer cells treated with romidepsin, it suppresses the expression of the p21 gene and increases the anticancer effect of romidepsin. Laboratory studies that combined romidepsin and flavopiridol demonstrated that the combination was up to 10 times better at inducing apoptosis in lung and esophageal tumor cells than either agent alone.
In this trial, patients with advanced thoracic cancers (cancers of the chest) or other cancers that have spread to the chest will be treated with romidepsin and flavopiridol. Researchers will study the safety of this combination, and how these agents affect gene and protein expression in these patients.
"Based on our preclinical studies, we believe that combining these agents will dramatically improve the cancer cell killing power of romidepsin in thoracic cancers and potentially in a broad range of solid tumors," said Dr. Nguyen.
Who Can Join This Trial
Study Site and Contact Information
An archive of "Featured Clinical Trial" columns is available at http://cancer.gov/clinicaltrials/ft-all-featured-trials.
NCI Director's Awards Ceremony Scheduled in October
Awardees will be announced in the following categories: NIH merit (group and individual); leading diversity (group and individual); length of service (30 and 40 years); outstanding mentor; mentors of merit; and Commissioned Corps' Public Health Service citation, outstanding service medal, and commendation medal.
The ceremony will be videocast at http://videocast.nih.gov.
Save the Date for AIDS Malignancy Program Conference
The conference will bring together scientists, physicians, health care workers, and community and patient advocates to focus on the viral oncology, immunology, genetics, epidemiology, pathogenesis, early diagnosis, and clinical investigation of malignant diseases associated with AIDS and other acquired immune-deficiency states. The event's objective is to facilitate the exchange of information between laboratory and clinical researchers to accelerate the translation of basic scientific discoveries into clinical applications.
The conference is free, but registration is required by October 9. For more information, go to http://www.palladianpartners.com/aidsmalignancy/index.htm.
FARE 2007 Winners Are Awarded
The annual NIH-wide FARE competition - sponsored by the NIH Fellows Committee, the Scientific Directors, the NIH Office of Research on Women's Health, and the NIH Office of Intramural Training and Education - provides recognition for outstanding scientific research performed by intramural postdoctoral fellows.
This year's FARE awardees include 91 fellows from NCI's CCR, Division of Cancer Control and Population Sciences, Division of Cancer Epidemiology and Genetics, and DCP. They also receive a certificate and $1,000 in support to attend a scientific conference of their choice, and are asked to serve as judges for the following year's competition.
To apply, each April, fellows submit abstracts of their research, which are then peer reviewed by a jury of scientists whose work received awards in previous years. Visit http://felcom.nih.gov/FARE for more details.
SBIR Program Announces New Contract Funding Opportunities
NCI Cooperative Groups Celebrate 50th Anniversary on Capitol Hill
Representatives from ASCO and the Coalition of Cancer Cooperative Groups (CCCG) hosted a September 19 congressional briefing to celebrate the 50th anniversary of NCI's Clinical Trials Cooperative Group Program. Research leaders from the two groups used it as an opportunity to highlight the tremendous advances in cancer research achieved by the cooperative groups, and to stress the need to maintain federal funding and support.
Since its founding in the mid-1950s, the Cooperative Group Program has completed more than 4,000 clinical trials and treated more than 500,000 patients. The program currently involves more than 1,700 institutions that contribute patients to group-conducted clinical trials. Cooperative groups place more than 25,000 new patients into cancer treatment clinical trials each year.
"Clinical trials are the vital link between laboratory discoveries and improved patient outcomes," explained Dr. Joseph Bailes, ASCO's CEO and interim executive vice president. "The cooperative groups' research through these clinical trials has brought improved outcomes to millions of people with cancer."
Dr. Bailes and CCCG President Dr. Robert Comis noted examples where research led by the cooperative trial groups has contributed to long-term survival and cures for the majority of pediatric cancers; proven that breast-conserving lumpectomy is often a better surgical option than radical mastectomy; developed paclitaxel as a premier treatment for ovarian and metastatic non-small-cell lung cancers; and defined the role of targeted therapies, such as trastuzimab and bevacizumab, in the major solid tumors.
"A significant portion of the cooperative groups' budgets - about $150 million per year - comes from NCI," Dr. Comis explained. "Unfortunately, declining funding has caused the institute to decrease cooperative group funding over the past 2 years, and we cannot hope to continue to provide the types of treatment advances that help people with cancer unless we reverse the trend of decreasing NCI funding."
When a congressional aide asked about the impact of the doubling of the NIH budget in previous years, Dr. Comis expressed appreciation for Congress' support, but noted that cooperative group funding is currently at the same level as in 2001. NCI funding has never covered the entire cost for each enrollee in a trial, he explained, so a lot of cooperative group efforts are on a volunteer basis, which is becoming harder to sustain, particularly among community-based clinicians and hospitals.Dr. Norman Wolmark, chair of the National Surgical Adjuvant Breast and Bowel Project Cooperative Group, said, "The Cooperative Groups received a $3 million decrease in 2006 compared to the previous year, and the projected decrease for next fiscal year is in the range of 10 to 15 percent. We really are at a crossroads and a crisis." For example, he added, the initiation of promising follow-up research on chemopreventive agents for breast cancer is in serious question due to the current budget uncertainties.