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Studies Suggest More Flexibility in Treating Advanced Colorectal Cancer
The results of two new large European clinical trials challenge the conventional thinking on the initial treatment of patients with advanced colorectal cancer, particularly those undergoing treatment almost strictly for palliative purposes, the studies' leaders say.
Published in the July 14 Lancet, the trials' results suggest that using either fluorouracil or capecitabine as single agents for first-line treatment in this patient population is no less effective and potentially less toxic than using a combination of two chemotherapy drugs, as is commonly recommended in the United States and Europe. Read more
Tackling Cancer Care Disparities in the Community
The theme of this issue of the NCI Cancer Bulletin is cancer health disparities, in conjunction with NCI's Cancer Health Disparities Summit 2007 held last week.
The summit convened a transdisciplinary cadre of more than 700 cancer health disparities investigators, health care providers, community partners, program managers, project staff, and civic leaders from across the country. NCI grantees from such programs as the Community Networks Program and the Patient Navigation Research Program were at the forefront of the 3-day event, discussing collaborations and partnerships, communications and bioinformatics, community engagement, managing and sustaining programs, and training and education. Read more
Studies Suggest More Flexibility in Treating Advanced Colorectal Cancer
The results of two new large European clinical trials challenge the conventional thinking on the initial treatment of patients with advanced colorectal cancer, particularly those undergoing treatment almost strictly for palliative purposes, the studies' leaders say.
Published in the July 14 Lancet, the trials' results suggest that using either fluorouracil or capecitabine as single agents for first-line treatment in this patient population is no less effective and potentially less toxic than using a combination of two chemotherapy drugs, as is commonly recommended in the United States and Europe.
However, several leading experts on the treatment of colorectal cancer in the U.S. and abroad cautioned against overinterpreting the trials' results, arguing that combination chemotherapy should still be the standard of care for the first-line treatment of most patients with advanced disease.
In both trials, there was no statistically significant difference in overall survival between patients treated with regimens in which either single agent was used as a first-line treatment before moving on to other chemotherapy drugs or combinations that have shown activity in this patient population, which they called a sequential or staged approach.
For patients who are undergoing treatment without curative intent, wrote Dr. Matthew T. Seymour, from Cookridge Hospital in Leeds, United Kingdom, and colleagues who led the larger of the two trials, dubbed FOCUS, the results provide "an important choice, informed by the knowledge that a decision to opt for a staged treatment approach, starting with less toxic therapy and keeping active agents in reserve, entails minimal, if any, compromise in survival."
The trials took somewhat different approaches in the staged-therapy arms, but both had one arm in which patients were randomized to combination chemotherapy for first-line treatment. FOCUS was the larger of the two, with more than 2,100 patients. The other trial, CAIRO, which used capecitabine as its single agent first-line therapy, had 820 patients.
In a commentary accompanying the trial results, Drs. Hans-Joachim Schmoll from Martin Luther University in Germany and Daniel Sargent from the Mayo Clinic cited several factors that support the limited use of a single-agent, first-line approach.
Several other clinical trials have shown that combination chemotherapy is superior to single-agent fluorouracil in improving overall survival, they wrote.
In addition, the first-line combination chemotherapy regimens used in FOCUS and CAIRO were not accepted standard regimens, which they argued was essential for any "trial designed to test a reduction in therapy."
Even in the context of palliative treatment, combination chemotherapy is most often the wisest choice, says Dr. Heinz-Josef Lenz, associate director of the Gastrointestinal Oncology Program at USC/Norris Comprehensive Cancer Center.
"The data are clear: Response rates are higher with first-line combination treatment, and progression-free survival is higher," Dr. Lenz says. That often translates into better palliation, he adds.
Use of a single agent as first-line therapy may be appropriate in some patients, advises Dr. Wasif Saif, director of the Gastrointestinal Cancers Program at Yale Cancer Center, such as those with a poor performance status and less aggressive disease in whom the intent is clearly palliation.
The trials' results "present very important options for certain patients, but," he cautions, "I still believe a lot needs to be done before we change the standard of care."
Dr. Saif stressed that identifying molecular biomarkers indicative of response to certain agents or treatments must be the highest research priority.
Dr. Lenz agreed, but explained that the pursuit of such biomarkers has been hampered by rapidly changing treatment patterns. He is hopeful, however, that there may now be a "window of opportunity" to develop and validate biomarkers for response to chemotherapy and targeted agents, primarily bevacizumab (Avastin) and cetuximab (Erbitux), which have shown a benefit in some patients with advanced colorectal cancer.
By Carmen Phillips
Tackling Cancer Care Disparities in the Community
The theme of this issue of the NCI Cancer Bulletin is cancer health disparities, in conjunction with NCI's Cancer Health Disparities Summit 2007 held last week.
The summit convened a transdisciplinary cadre of more than 700 cancer health disparities investigators, health care providers, community partners, program managers, project staff, and civic leaders from across the country. NCI grantees from such programs as the Community Networks Program and the Patient Navigation Research Program were at the forefront of the 3-day event, discussing collaborations and partnerships, communications and bioinformatics, community engagement, managing and sustaining programs, and training and education.
Cancer health disparities continue to be a tremendous public health challenge. A recent study, led by the American Cancer Society, found that people who are without health insurance or on Medicaid are far more likely to be diagnosed with advanced cancer than those with private insurance. Another study, which documented the underuse of surgery to treat early-stage pancreatic cancer, found that African American patients were far less likely to be offered surgery and more likely to refuse surgery.
Both studies highlight the complex economic, social, educational, and cultural factors that contribute to cancer care disparities - and reinforce the importance of identifying the most effective ways to address this unacceptable deficit in cancer care and outcomes.
A key part of the mission of the recently launched NCI Community Cancer Centers Program (NCCCP) is to research new and enhanced ways to assist, educate, and better treat the needs of underserved populations. The 16 participating sites - community hospital-based cancer centers that already offer a combination of medical, surgical, and radiation oncology care - must use 40 percent of the NCCCP funds they receive from NCI for disparities-related activities.
The cornerstones of these activities are expanded outreach and patient navigation, with the aim of allowing us to better study how to improve access to care and bring the latest scientific advances to all patients.
Expanded outreach will focus on improving primary and secondary prevention, including programs for smoking cessation, mammography, and colorectal cancer screening. Partnerships between NCCCP sites and community-based health and civic organizations will ensure the widest possible reach to at-risk populations.
Expanded prevention and screening programs can only be effective if there is a process in place to get care to those who need it. That is why NCCCP sites must ensure that people who are screened through their programs will receive necessary treatment. This reinforces the need for strong patient navigator systems, so that those who have abnormal findings during a screening and are diagnosed with cancer have the tools available to ensure they gain timely access to quality oncology care. This pilot program will improve our ability to identify barriers to treatment and follow-up and lead to the best models for effectively moving patients from diagnosis to treatment to posttreatment care.
One of the NCCCP pilot's most important goals is to seek broad-based and sustainable models that include public/private partnerships to address the unmet health care needs of their communities. If we are going to make significant progress toward reducing cancer care disparities, public institutions, private industry, and community-based organizations must work together to bring state-of-the-art cancer care to all patients, not just a privileged few.
Dr. John E. Niederhuber
New Metastatic Breast Cancer Treatments Improved Survival Over Time
A Canadian population-based study, published online July 23 in Cancer, found that survival among women diagnosed with metastatic breast cancer (MBC) in British Columbia has improved over the past decade, and that this appeared to be related to the introduction of several new therapeutic agents for MBC during the 1990s.
Researchers from the British Columbia Cancer Agency (BCCA) analyzed data from 2,150 women in the Canadian province who were diagnosed and treated in 1 of 4 "time cohorts" spanning the 1990s. The earliest cohort (1991-1992) was the baseline, while subsequent cohorts were matched against the introduction of new agents for MBC: (1994-1995) paclitaxel and vinorelbine; (1997- 998) aromatase inhibitors and docetaxel; and (1999-2001) trastuzumab and capecitabine.
"There was a significant improvement in survival for women with MBC over time," the scientists reported. "Although there was no difference between the first two cohorts, the later two cohorts had significant improvements in overall survival." The median survival for patients in cohorts 1 through 4 was 436 days, 450 days, 564 days, and 661 days, respectively. "Survival of women who were diagnosed with MBC in [British Columbia] in the later part of the 1990s improved by approximately 30 percent compared with a similar cohort of women who were diagnosed in the early and middle parts of the 1990s," they added.
"Although MBC still is an incurable disease, this study provides optimism for those women who are diagnosed with MBC today and should provide enthusiasm and evidence that continued research to discover better therapies may translate into further improvements in outcome in the future," they concluded.
"Tumor Paint" May Improve Excision of Multiple Tumor Types
Researchers from Fred Hutchinson Cancer Research Center and collaborators in Seattle have developed a fluorescent bioconjugate that targets numerous tumor types with high resolution. The details of their study appeared July 15 in Cancer Research.
The researchers called their molecule "tumor paint," building it from chlorotoxin, a scorpion venom protein that is nontoxic in mammals and has been shown to target glioma cells, and Cy5.5, a molecule that emits fluorescent light without requiring enzymatic cleavage within the cell and with minimal light absorption by water or hemoglobin.
After administering an early version of tumor paint to mice, the researchers found that adding Cy5.5 to chlorotoxin improved its tumor-targeting ability. "The resolution of cancer foci from normal tissue under simulated operating conditions was exquisite," down to the level of a few hundred cells, they wrote.The team tested this conjugate in mouse models of medulloblastoma, sarcoma, and prostate and intestinal cancer, and found that it worked well in elucidating each of these tumors for as long as 15 days after administration.
The researchers suspect the specific target of the chlorotoxin on the cell membrane may be matrix metalloproteinase-2 (MMP-2). They transfected cells that failed to bind to tumor paint with plasmids containing MMP-2 and found that this facilitated attraction. Microscopy showed that the tumor paint and the MMP-2 clustered within the transfected cells. However, pull-down assays were unable to show a direct bond between MMP-2 and tumor paint, and other experiments were unable to show an enzymatic relationship between them.
Algorithm Predicts Response to Anticancer Drugs
A team led by researchers from the University of Virginia at Charlottesville has developed an algorithm that uses comparative microarray data and responses of a panel of 60 human cancer cell lines maintained by NCI (NCI-60 panel) to anticancer drugs to predict responses in other cell lines and in human tumors. The study, published in the July 24 Proceedings of the National Academy of Sciences, then used the algorithm to identify experimental compounds with potential activity against bladder cancer.
The algorithm, called COXEN, consists of several steps: determining a drug's molecular activity in a first set of cells (in this case, the NCI-60 panel); measuring the normal molecular characteristics of those cells; identifying which molecular characteristics most accurately predict the drug's activity; measuring those characteristics in a second set of cells; identifying a subset of molecular characteristics that shows a pattern of coexpression between the two cell sets; then predicting the drug's activity in the second set based on its activity in the first set and the molecular characteristics shared between the two.
When tested using a panel of 40 human bladder cancer cell lines (BLA-40) as the second set of cells, COXEN significantly predicted response of BLA-40 to the drugs cisplatin and paclitaxel. The researchers then modified the algorithm to test whether it could predict in vivo response in human tumors from the NCI-60 in vitro data. When comparing NCI-60 molecular characteristics with microarray data from two breast cancer clinical trials, one of docetaxel and one of tamoxifen, COXEN significantly predicted clinical response to both drugs.
Finally, the investigators used COXEN to predict chemosensitivity patterns of BLA-40 cells to 45,545 experimental compounds screened using the NCI-60 panel. They identified eight compounds to which more than 50 percent of BLA-40 cells were predicted to be sensitive, thereby finding possible candidates for early clinical trials.
The investigators, which include John N. Weinstein of NCI's Center for Cancer Research, caution that "our COXEN approach needs to be further validated before it is applied in clinical practice." They will make the algorithm available to the scientific community at http://www.coxen.org in September, 2007. The NCI-60 microarray data are at http://discover.nci.nih.gov.
SPORE Investigators' Meeting Highlights Upcoming Program Changes
On July 7-10, NCI hosted the 15th Annual Investigators' Workshop for the Specialized Programs of Research Excellence (SPOREs) translational research grants which are designed to help participating cancer centers move basic research findings from the laboratory to clinical settings as rapidly as possible. NCI currently funds 57 SPORE grants covering 14 cancer types.
The 2007 investigators' workshop gave SPORE researchers working on the same cancer type a chance to share results and pursue opportunities for collaboration. A special session on Saturday focused on the challenges found in using biomarker evidence in translational research, including tissue acquisition and sample size requirements for clinical trials, methods for quality assurance, and validation of the clinical utility of a potential biomarker.
The theme of collaboration grew in importance this year, as the SPORE program readies itself for a major programmatic shift. Instead of keeping the focus of the SPOREs on the 14 current cancer types, explained Dr. Jorge Gomez, chief of NCI's Organ Systems Branch, beginning in 2008 competition for the grants will be open to any type of cancer.
"The program has been and remains very popular," said Dr. Gomez. "Many groups want to compete and participate." He hopes that the increased competition will encourage collaborators from different institutions to apply together for a single SPORE grant, instead of the majority of applications coming from single institutions as they do now.
Breast Cancer Survivors Test Diet High in Fruits, Veggies
Women who adopted a low-fat diet that was very rich in vegetables, fruit, and fiber after treatment for breast cancer did not reduce their risk of recurrence compared with similar women who consumed 5 or more servings of fruits and vegetables a day. After 7 years, both groups of women had essentially the same risk of recurrence, incidence of new primary breast cancers, and risk of overall mortality.
Even women whose diets at baseline were low in fruits, vegetables, or fiber or high in fat did not appear to benefit from the intervention, according to findings in the July 18 Journal of the American Medical Association (JAMA). The results are from the Women's Healthy Eating and Living (WHEL) study, a randomized controlled trial that included 3,088 women who were treated for early-stage breast cancer.
The researchers caution against applying their findings to populations beyond those in the study, which included women who had completed their initial therapy and excluded women diagnosed after age 70. The findings appear to be at odds with interim results from the Women's Intervention Nutrition Study (WINS), which suggest that a low-fat diet may help prevent breast cancer recurrence in some women.
Different patterns of weight gain and loss between the trials may account for some of the varying results, according to an editorial in JAMA. Women in both arms of the WHEL trial on average gained weight, whereas women in the intervention arm of WINS lost weight. New studies that assess interventions based on physical activity and energy intake for breast cancer survivors are warranted, the editorial concludes.
Dr. Springfield is director of NCI's Center to Reduce Cancer Health Disparities (CRCHD).
Why is the Cancer Health Disparities Summit important?
What did this year's summit achieve?
Why do you think cancer health disparities are getting greater attention these days in the research community?
What are some of the key initiatives of CRCHD?
For example, in our Disparity Research program, we have the Minority Institution/Cancer Center Partnership Program, in addition to the CNP and PNRP initiatives. The objectives of the Minority Institution/Cancer Center Partnership program are to increase the participation of Minority Serving Institutions in the nation's cancer research and research training enterprise; to increase the involvement and effectiveness of the Cancer Centers in research, research training, and career development related to minorities; and to develop more effective research, education, and outreach programs that will have an impact on minority populations.
Our Diversity Training portfolio houses the Continuing Umbrella of Research Experiences (CURE). Through this program, we strategically address each level of the biomedical research and educational pipeline to increase the pool of underrepresented minority candidates, emphasize scientific areas of greatest need, and expand and extend the period of training and career development. Given the increased emphasis of cancer health disparities, we need to attract more minority biomedical scientists into the cancer research field. In that regard, CURE has shown great promise and results over the years.
Cancer Prevention Starts at Home (with a Party)
In Washington State, researchers are sponsoring "home health parties" to raise awareness about cancer and encourage people to take advantage of free screenings. The goal is to reduce health disparities among underserved populations.
"We think of these as Tupperware parties without the sale," says Dr. Beti Thompson of the Fred Hutchinson Cancer Research Center. Her team is testing the experimental strategy in Hispanic communities in the Lower Yakima Valley.
The researchers recruit families to host the gatherings in their homes and then send a trained health educator to lead a discussion on a specific cancer topic. Parties last about an hour and may include 5 to 8 family members and friends (sometimes more). The events are informal with lots of time for questions.
"We talk about how cancer develops and the importance of screening," says Ilda Islas, also of Fred Hutchinson. The information is usually new to the families, and many do not know that they can take steps to prevent cancer, she adds.
The cancer topic changes every 6 months. The researchers plan to cover cervical, colon, prostate, breast, lung, and skin cancers. Six months after a party, the health educators, or promotoras, follow up to see if a family has questions or would like a refresher course.
Preliminary data from the study are encouraging. Nearly a quarter of the 70 individuals who attended recent parties on colon cancer (and were eligible for screening) subsequently underwent screening.
"We think those are pretty good odds," says Dr. Thompson, who is supported by NCI's Community Networks Program. "This is a unique strategy, and it appears to work well."
It works well for some of the same reasons that Tupperware parties do. People learn about cancer among friends, often without having to leave their homes. Parties can occur in the evenings after work, and no babysitters are needed because the whole family is involved.
Children often hear the same discussions as their parents. The family is central in Hispanic culture, and family members can provide social support for individuals who are considering cancer screening, notes Dr. Thompson.
Another important element is the promotoras. These individuals are recruited from the communities they serve. They know the culture and understand how to reach their audiences, which may include friends and acquaintances.
"The parties are a great experience," says Ms. Islas. "People receive us with open arms, and they express their gratitude for the information we have shared with them."
The researchers first experienced this welcoming response several years ago as they went door to door, telling families about the dangers of pesticides. Many families invited them inside to talk, and this led to the current strategy.
Once the home health parties began, the news spread by word of mouth. Ms. Islas initially went to community events and churches to recruit families, but she now handles requests from people wanting to host parties. The researchers plan to publish their results and lessons learned. If the pilot program is a success, they say, the strategy could be adapted for other Hispanic and Latino populations. The primary materials are large flip charts that can be carried from home to home.
"We've been absolutely amazed by how many families have opened their doors to us," says Dr. Thompson. "Most people are very happy to have someone talk to them about health issues."
By Edward R. Winstead
Triple-Negative Breast Cancer Disproportionately Affects African American and Hispanic Women
Triple-negative breast cancer primarily consists of a molecular subtype called the basal-like subtype. Different molecular subtypes of breast cancer can now be identified in patients by gene-expression profiling.
The first hints that molecular subtypes of breast cancer may not be distributed equally among populations in the United States emerged several years ago, and in 2006, results from the Carolina Breast Cancer Study (CBCS) showed that 39 percent of premenopausal African American women diagnosed with breast cancer had basal-like disease, compared with 14 percent of postmenopausal African American women and 16 percent of non-African American women of any age. In early 2007, a study from the California Cancer Registry confirmed the higher incidence of triple-negative breast cancer in young African American women and also identified a smaller but significant increased prevalence in Hispanic women.
Researchers are now attempting to answer the complex question of why this unequal distribution among various racial and ethnic groups exists. "The obvious question, if you recognize that there are subtypes of breast cancer," said Dr. Lisa Carey, medical director of the University of North Carolina Breast Center and lead author of the CBCS paper, "is to stop saying 'what causes breast cancer?' and say 'what causes different subtypes?'"
Intriguing data from the Nurses Health Study, the Women's Health Initiative, and smaller studies suggest that risk factors might be different for different subtypes of breast cancer. Follow-up results from the CBCS and from a large, population-based breast cancer case-control study conducted in Poland identified elevated waist-to-height ratio, excess weight gain since childhood, lack of breast-feeding after pregnancy and use of lactation suppressants, and several other variables as potential risk factors for basal-like breast cancer.
Now researchers led by Dr. Sarah Gehlert, director of the Center for Interdisciplinary Health Disparities Research (CIHDR) at the University of Chicago, have begun a unique, multidisciplinary study looking at the social environment (including crime) and other community factors that contribute to social isolation, reported perceptions of stress, and levels of salivary cortisol - a hormone involved in the response to stress - in a group of African American women in Chicago to determine if stress and social isolation contribute to breast carcinogenesis. "It's a completely integrated model," explained Dr. Gehlert.
"We realized from our animal work that social isolation was a very significant feature" in tumor development, said Dr. Gehlert. Their study hypothesis, she explained, is that "women who live in areas with…a lot of violent crime, and who live in unsafe housing, without a lot of community support to make it easier to deal with that stress, will be more likely to have sporadic mutations and will have [worse outcomes] with breast cancer."
An important part of this integrated model is the collection of tumor tissue from participants. Interim results from the study have already found glucocorticoid receptors in tumors of women who reported high stress levels, indicating that an altered stress response may contribute to failure of apoptosis and lead to tumor growth.
The tissue collected will be analyzed by Dr. Olufunmilayo Olopade, professor of medicine and human genetics at the University of Chicago and one of four project leaders in CIHDR. Dr. Olopade's previous work with African women in Nigeria and Senegal has shown an even higher incidence of estrogen-negative breast cancer than that found in African American women. Her laboratory is now deeply involved in determining if genetic mutations similar to BRCA1 and BRCA2 may contribute to the disparity in triple-negative disease under study by CIHDR.
Work is also now beginning across the U.S. to better understand the impact of triple-negative breast cancer in the Hispanic population. "We're concerned about this triple-negative phenomenon and whether Mexican Americans are also facing a similar [disparity]," explained Dr. Melissa Bondy, professor of epidemiology at the University of Texas M.D. Anderson Cancer Center. Dr. Bondy and her colleagues are starting a study to examine risk factors for triple-negative breast cancer in Mexican American women living in Texas and Arizona, and Mexican women from Northern Mexico and from the city of Guadalajara.
The next steps for researchers will be to figure out ways to help these populations reduce their risk and to develop new treatment options for triple-negative breast cancer, which are limited to traditional surgery, radiation therapy, and chemotherapy.
"The whole point [of the Carolina Breast Cancer Study] was…to figure out what the population frequencies were of these different subtypes and what some of the clinical associations were so that we could design trials for them," said Dr. Carey.
Dr. Carey's group and others around the country are now involved in large, multi-institution clinical trials testing therapies for triple-negative breast cancer. Drug regimens being examined in these trials include the antiangiogenesis agent bevacizumab given before surgery; new, targeted drugs that interfere with cell-signaling pathways other than those triggered by the estrogen, progesterone, and HER2 receptors; and platinum-based chemotherapy drugs, which may be effective in triple-negative disease.
By Sharon Reynolds
Education and Exercise to Prevent Lymphedema
Name of the Trial
Principal Investigator
Why This Trial Is Important
There is no known cure for lymphedema, but some measures can make it easier to live with or possibly prevent it. Women who undergo axillary node dissection should receive education about how to recognize and possibly prevent lymphedema.
This study compares a lymphedema-prevention education program to the same education program supplemented with an exercise regimen and counseling in women who have been newly diagnosed with breast cancer and who will undergo axillary node dissection. Researchers want to see if education, exercise, and counseling will help prevent lymphedema or limit its severity if it develops.
"As many as one-third of women who undergo full axillary node dissection will experience lymphedema," said Dr. Paskett. "These women may suffer serious physical, social, and psychological effects because of this condition. We hope these interventions will help breast cancer survivors enjoy a better quality of life."
Who Can Join This Trial
Study Sites and Contact Information
An archive of "Featured Clinical Trial" columns is available at http://cancer.gov/clinicaltrials/ft-all-featured-trials.
If Memory Serves...
The link between smoking and cancer was first noted in scientific literature in the 1930s, at a time when the smoking prevalence in the United States was rising, particularly among soldiers who received cigarette rations during World War I. The first large epidemiological study proving this link, however, wasn't published until 1950. (Read more)
For more information about the birth of NCI, go to http://www.cancer.gov/
Russian Federation Holds First Meeting on Tobacco Control
The idea for this conference came from Dr. Nikolay Gerasimenko, deputy chairman of the Health Care Committee of the State Duma of the Russian Federation, who attended the 13th World Conference on Tobacco OR Health in Washington, DC, in 2006. NCI, through the American-Russian Cancer Alliance (ARCA), and in partnership with the American Cancer Society (ACS), had hosted Dr. Gerasimenko's visit.
Rep. Steny Hoyer (D-MD) conveyed greetings and praised NCI, ACS, and ARCA for their participation in the forum. The forum was followed by a number of related activities including a congress of Russian physicians against tobacco, conferences, and public campaigns devoted to World No Tobacco Day on May 31 in all regions of the Russian Federation.
The forum also issued what was termed the "Moscow Statement on Tobacco Control." In response to the forum, the Russian Anti-Tobacco League has been formed to serve as the combined voice of anti-tobacco forces in the Russian Federation. During the forum, the Duma gave tentative approval to legislation that would restrict smoking in restaurants and several other public places, and in July the foreign ministry announced that Russia will join the Framework Convention on Tobacco Control.
The forum is likely to be repeated in 2009 and become a regular event in Russia. More information about the forum can be found at http://www.antitabak.ru/eng/index.php.
NCI Develops Cancer Risk Prediction Resources Web Site
The Web site was designed for investigators developing, evaluating, and applying risk prediction models for cancer risk and susceptibility. It includes citations and links for all the risk prediction models published to date, categorized by cancer site. It also includes links to the 2004 NCI workshop on Cancer Risk Prediction Models, funding opportunities, other relevant publications, and Web sites related to risk prediction.
When used by scientific experts who understand the strengths and limitations of the various models available, risk prediction models provide an important approach to assessing risk and susceptibility by identifying individuals at high risk, facilitating the design and planning of intervention trials, and enabling the development of benefit-risk indices and estimates of population burden and cost of cancer.
Health Behavior Constructs Web Site Launched
Media Panel Invites Summit Researchers to Get to Know Them
What did journalists have to offer a gathering of cancer researchers and advocates at NCI's Cancer Health Disparities Summit? Plenty. That's what summit participants found out on July 18 during the plenary session, "Health Disparities in the News: Getting the Word Out."
Providing insight into how they work, the journalists left a clear and direct message with summit attendees: The ethnic media needs to be taken more seriously; they deserve to be viewed as a legitimate "go-to" source for audiences interested in health disparities and other news. In addition, the journalists encouraged researchers and community-based advocates to learn more about the ethnic media in their own communities and establish relationships with those media outlets.
"You really can call reporters. It's okay," said George Strait, former chief medical correspondent for ABC News and more recently the communications director for NIH's National Center on Minority Health and Health Disparities. Mr. Strait, who covered NIH as a reporter, moderated the panel, which included Sandra Basu, American Indian health beat writer for U.S. Medicine; Stella Choi, writer for the monthly Asian Fortune magazine; Hazel Edney, editor-in-chief of the National Newspaper Publishers Association/Black Press USA; Dr. Elmer Huerta, radio and TV host and founder of the Cancer Preventorium in Washington, DC, for the Hispanic community; and Viji Sundaram, health editor of the country's only major nationwide news service for ethnic media, New America Media.
"What best gets the attention of our editors and readers is when we give them the 'what to do.' Not just the statistics, but what can you do?" said Ms. Edney. "You've done a great job telling us the wheres and the whys and the statistics."
Ms. Sundaram talked about how her calls to other federal agencies and corporations are often met with dismissive attitudes, simply because she is not calling from a major media outlet. She cautioned that this is a mistake.
Many people will remember Dr. Huerta's presentation. He began with a series of graphic displays of the ravages of breast cancer. He used that as his prop to discuss what drives him in his work, both as a member of the media and as a practicing oncologist. Dr. Huerta said that too many Hispanics have more access to the latest soccer scores and happenings on soap operas than to reliable cancer information. As a result, he works to get the word out through five radio shows and three television programs. "I'm always asking myself, 'What can we do?'"
That seemed to be the prominent question on everyone's mind during the summit: "What can we do?" It appears that the panel of journalists may have helped open up some new avenues in answering that question.
By James Alexander
Following are newly released NCI research funding opportunities:
U.S.-India Bilateral Collaborative Research Partnerships on the Prevention of HIV/AIDS
This funding opportunity will use the R21 award mechanism. For more information, see http://cri.nci.nih.gov/4abst.cfm?initiativeparfa_id=3744. Inquiries: Dr. Kishor Bhatia - email@example.com
Nutrition and Alcohol-Related Health Outcomes
This funding opportunity will use the R01, R03, and R21 award mechanisms. For more information, see http://cri.nci.nih.gov/4abst.cfm?initiativeparfa_id=3743. Inquiries: Dr. Sharon Ross - email@example.com
Mechanisms of Immune Modulation
This is a renewal of RFA-AT-06-004 and RFA-AT-06-005 and will use the R01 and R21 award mechanisms. For more information, see http://cri.nci.nih.gov/4abst.cfm?initiativeparfa_id=3745. Inquiries: Dr. Young S. Kim - email@example.com


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Fingers crossed for you, Bridget!
Fingers crossed for you, Bridget!
D-Mama (37) D-Dada (43) and D-Baby (11/02/2011)
So of my adoption group, three couples dropped out due to getting pg. One brought home a little boy in the spring. I just heard that another has just gotten a little boy! I am so excited for them....they are the ones we went out of town for last month to visit. So that just leaves one couple and DH and I. I have always believed that we would be the last in our group to be matched and am ok with that. Now our group has two boys....wonder if the two of us left will have girls? I'm kind of hoping for a girl....slight preference most of the time. But OMG it is so exciting to see the process is working.
Pooh, I got the chills for you Jen. Looking so hopeful.
Bridget, let's hope the doctors find answers for Kai.
I'm at the DMV now for my license. I had an appointment, and the line for appts is as long as the non-appts. The other line is moving faster too. If I could bottle up the discontent of everyone
in this line to one day unleash it all on one of my enemies, I'd have one powerful weapon. KILL. ME. NOW.
I actually have happy DMV stories. Yesterday, I took my parents there to get an ID for mom (who wants to walk around with a passport all the time?), and to replace dad's lost license. The plan was for me to go grocery shopping while they waited. Well, the whole thing, for both of them took 20 minutes. Heck, they hadn't even finished filling out their paperwork by the time they were called. Impressed with service, which just about never happens.
Jen, I hope it happens for you really really soon.
Bridget, I hope you get some answers at the doctor today!
Jennifer, I'm always hopeful that you'll get your baby soon!
Ugh....DMV. Ours changed the requirement for a license and if I lose mine or don't move out of state before mine expires in 2016, I probably won't even be able to get one lol.
They want you to bring a passport, SS card, marriage license, birth certificate, 2 proof of residencies, which can be invoices or a mortgage or lease, and some thing else. I do not have anything in regards to proof of residency and when I called to ask about it, they said it has to be a water bill or electric bill since those are the only ones here that are considered proof of residency as they have to be in the payee's name. DH's name is on both of those, as well as the mortgage as he bought the house, for me, before we got married. I am on the deed but not the mortgage statement. So basically they said, I would have to add myself on a bill, which will cost $80 to $150 in deposits at the water and/or electric company AND since I have a bankruptcy on my record from 2006, I will have additional deposit fees of another $100-$200 dollars. And I refuse to get that done.
These were new rules in regards to the threat of identity theft. I don't see how that is even an issue when they keep your picture on file at the DMV. So if someone comes to get a license they should be able to tell immediately that it isn't you.
Myles, even funnier is I read it as ooh and didn't notice the autocorrect to Pooh until you said something. LOL
Chrissy, oh yeah I would love a little boy too. But like many, we have always had a slight preference for a girl....though the boy name one is the one we have been set on for years and years and years.
I'm cool too if it takes a while longer. Gives me time to try to save up a bit more PTO and money and get things together. Plus I know DH and I were the last of our group to finished with the home study. We all did classes together but I know others were done with the portfolios and home visits in April or May. We were August.
Buying little things here or there really helps. I mean I already have the nursery decor in the closet, paint colors matched, a pack n play, up to 6 diapers, 6 cloth wipes, got a wet bag arriving probably today in the mail. A few toys, a puzzle. Just a little thing here or there....especially if I need a bit more to get free shipping at amazon. I have done a ton of window shopping online and have stuff in carts just waiting to be bought. So if I needed to move suddenly, I could.
Don't think that our DMV was bad last time we were there....but when you are in a smaller town, I think that helps.
Oh, I've been pleasantly surprised by DMV too on occasion, and an old family friend works at ours so if she can bend the rules she will...but only in things like ID because she knows us. In fact, she babysat me & my brother. But most the time it's a huge PITA. My biggest beef with them is they will often write in to the local paper whining that we shouldn't ever do any of our DMV business online because (in NY at least) if you do the transaction locally, the local DMV gets a portion of the fee, whereas doing it online 100% of the transaction goes to Albany. Well, I'm sorry. You're closed at 4:30 and not open on weekends. I refuse to take off work to renew my license. If you want my business, have later hours or be open till noon (at least) on Saturday.
Actually, the DMV wasn't all that terrible. I was just being poopy because of the whole lining up even if you had an appointment thing. My appt was 10:20. I got there at 10:14, and waited until 10:45. Once I got to the front, I had to fill out paperwork, return it to the lady who checked you in for appointments, and I was issued a number. I got my # around 10:55. They called my # at around 11:10. I spent 5 mins with the clerk, paid my fee, got fingerprinted, then sent to the photo line. It took another 5 minutes to get my picture taken and I was out of there. The most interesting thing was listening to the conversations that the strangers struck up with one another in line. There was a strong show of solidarity between all those people who were stuck in the queues.
Jennifer, do you ever look at baby stuff on Etsy? There are so many crazy adorable things on there.
Erin, that is ridiculous! There are probably a lot of households that are now in your shoes due to the proof of residency requirement. I don't think the bureaucrats thought the process through for everybody.
Or DMVs around here are hit or miss. On a good day, you're in, you're out, boom, done. But on a bad day, OMG. Standing in line forever, no this line isn't doing that type of transaction, you need that line, waiting, sorry, this line is closing, go back to that other line, yes, the one you just left, they'll do it now since this one is closing.....
It doesn't help that I, by state law, have to connect the names from my birth cert to my social security card. Which means showing my birth certificate (LName1), my adoption papers (LName2), first marriage cert (LName3), divorce cert, and then second marriage cert (current LName on my SSN). For this most recent renewal, we had moved house since the last time, and I couldn't find most of my paperwork. I put it off for 5 months, got a ticket for driving on an expired license, finally tore the house apart to find the paperwork, and when I took it all in for the renewal...they didn't even look at a single piece of it. Not. One. Piece. I asked (twice!) and they assured me I would need to show it next time but did not offer any satisfactory explanation as to why this time was exempt. I was really mad, even though I knew it was stupid to be mad about. At least now I know where all my paperwork is.
D-Mama (37) D-Dada (43) and D-Baby (11/02/2011)
Geez that is overkill Erin. I think in WI you just need your SSI card for proof of citizenship and one proof of residency. They will accept a huge number of things for that, insurance bills that are current, hunting license, pretty much any bill with your name and address on it, work pay stubs, bank statements, college stuff...basically anything less than 90 days old with name and address on it. You only need proof of name and birth if it's the first license. If you have one that has current or expired less than 8 years ago, that works just fine.
Just home. Everything on ultrasound looked normal. But his blood test showed his glucose level to be 139. She said normal for children is 90(?)-126.
I'm confused that the other dr said his urine glucose was normal and that I asked her twice if we had ruled out diabetes with that test and she said yes.
This urologist has referred us to a new pedi in our town since I'm not going back to our old one. She wants this pedi to check his blood glucose again since they never rely on one test and then take it from there.
So now I'm not less worried but more worried.
No I haven't actually spent any time at etsy or really know much about it.
Dana, I didn't know you were adopted! so you have two birth certificates? We were told to make sure to request one for the baby before the adoption was final. Once we finalize in court, they will issue us a birth certificate for the baby listing us as the parents and the first one basically disappears and is impossible to get....which is why they say to request it as later many kids like to have that first one.
My MIL is going through that all with paperwork. She going to be divorcing #3 this spring. Though I think that after #2, she went back to her first married name....which is the one DH and I have. So she was MIL G, than MIL S, than MIL F, back to MIL S and I think that she never officially changed to her current husband's name.
Right now she is looking for paperwork from husband #2 who is dead now as we are pretty sure that she can collect some SSI from him soon as divorce from #3 happens. Hopefully he was getting enough that she can collect that and work part-time and be semi-retired and put off collecting her own a few years. Once the divorce happens, we would like to get her out of Chicago and either back in Milwaukee with her family or up by us. She will be 62 in the early spring.
Could there be another culprit besides error in test results or diabetes? It really makes you wonder how much you can trust a lab if the 1st one was so confident that he was fine.
Well the first one was urine and the second was blood. The urologist said that he's have to be extremely high for it to spill over into his urine. So that has me wondering why she was so confident to rule it out? (the first dr, that is.)
I'm calling the new pedi right now.
Last edited by Bridget; 10-18-2012 at 01:31 PM.
Bridget, I'm sorry this has raised more questions instead of solving the questions you already have.
Someone mentioned Montessori methods as an alternative to usual public school methods. Do any of you have any favorite Montessori websites with some activities I can try out at home?
I looked up that book, Raising Your Spirited Child, on amazon. You know they have that feature where you can read part of the book. They have a good bit of it on there and it did seem to hit the mark with a lot of Josh's behaviors. Except, it did keep referring to behaviors from infancy and really it seemed like he wasn't that unusual until he was 2.5 or 3. It does a lot of reassuring that you're not a bad parent, your child is not crazy, etc. I know Josh and I and DH butt heads a lot so I am definitely looking for a different approach.
I know. And this is the homeopathic dr we paid for out of pocket. Grrrr.
She said children don't fast for them.
I just called and they got me in tomorrow. Kai is pissed that he has to have another skin prick. Imagine if we have to do insulin every day????
That info is from this book...one of the ones I use the most. http://www.amazon.com/Mosbys-Diagnos...e+10th+edition
I can copy and send you the pages if you want.
Tests and diagnosis
In June 2009, an international committee of experts from the American Diabetes Association, the European Association for the Study of Diabetes and the International Diabetes Federation recommended that type 1 diabetes testing include the:
If the A1C test isn't available, or if you have certain conditions that can make the A1C test inaccurate — such as if you're pregnant or have an uncommon form of hemoglobin (known as a hemoglobin variant) — your doctor may use the following tests to diagnose diabetes:
- Glycated hemoglobin (A1C) test. This blood test indicates your average blood sugar level for the past two to three months. It works by measuring the percentage of blood sugar attached to hemoglobin, the oxygen-carrying protein in red blood cells. The higher your blood sugar levels, the more hemoglobin you'll have with sugar attached. An A1C level of 6.5 percent or higher on two separate tests indicates you have diabetes. A result between 5.7 and 6.4 percent is considered prediabetes, which indicates a high risk of developing diabetes.
If you're diagnosed with diabetes, your doctor will also run blood tests to check for autoantibodies that are common in type 1 diabetes. These tests help your doctor distinguish between type 1 and type 2 diabetes. The presence of ketones - byproducts from the breakdown of fat — in your urine also suggests type 1 diabetes, rather than type 2.
- Random blood sugar test. A blood sample will be taken at a random time. Blood sugar values are expressed in milligrams per deciliter (mg/dL) or millimoles per liter (mmol/L). Regardless of when you last ate, a random blood sugar level of 200 mg/dL (11.1 mmol/L) or higher suggests diabetes, especially when coupled with any of the signs and symptoms of diabetes, such as frequent urination and extreme thirst. A level between 140 mg/dL (7.8 mmol/L) and 199 mg/dL (11.0 mmol/L) is considered prediabetes, which puts you at greater risk of developing diabetes.
- Fasting blood sugar test. A blood sample will be taken after an overnight fast. A fasting blood sugar level less than 100 mg/dL (5.6 mmol/L) is normal. A fasting blood sugar level from 100 to 125 mg/dL (5.6 to 6.9 mmol/L) is considered prediabetes. If it's 126 mg/dL (7 mmol/L) or higher on two separate tests, you have diabetes. A level from 100 mg/dL (5.6 mmol/L) to 125 mg/dL (6.9 mmol/L) is considered prediabetes.
Honestly I am shocked that they didn't have him fast and I don't know why they said children don't fast.....when checking for type 1....they are pretty much almost always children...most common age tends to be 4-6 yrs old and another spike in early teen years.
Last edited by Cosmosmom; 10-18-2012 at 02:34 PM.

subset: commoncrawl


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Are you getting a flu shot, and if so, when?
I'm leaning toward yes, because I don't want to get the flu and confuse it with HELLP symptoms. I'm just not sure how late to get it..I don't want the benefit of it to run out before the flu season is over. (And yet I don't want to wait too long because who knows when I'll end up delivering!)


text:
John Sununu, a top advisor to Mitt Romney, is facing criticism for saying that former Army General and Secretary of State Colin Powell endorsed President Barack Obama because of race.
"Frankly, when you take a look at Colin Powell, you have to wonder whether that's an endorsement based on issues or whether he's got a slightly different reason for preferring President Obama," Sununu said on CNN's Piers Morgan Tonight.
When asked what that reason would be, Sununu said it was race.
"Well, I think when you have somebody of your own race that you're proud of being president of the United States, I applaud Colin for standing with him," Sununu replied.
Soon after the response, "John Sununu" began trending on Twitter, with most responses criticizing the former governor of New Hampshire for his response.
"If John Sununu thinks Colin Powell endorsed Obama because of he is black, is it fair to assume Sununu endorsed Romney because he is white?," tweeted @WillMcAvoyACN, a parody account of the popular character from HBO's The Newsroom.
Touré , the co-host of MSNBC's The Cycle, tweeted, "John Sununu supports Romney. Is this because he wants to see a President of his own race? Why's it sound absurd that way but not for Blacks?"
And comedian Eugene Mirman also weighed in.
"Criticize John Sununu all you want, but the same thing was said about Wesley Clark's racially motivated endorsement of Kerry in 2004," he tweeted.
After the backlash, Sununu took back his statement.
"Colin Powell is a friend and I respect the endorsement decision he made and I do not doubt that it was based on anything but his support of the president's policies," Sununu said, according to Politico. "Piers Morgan's question was whether Colin Powell should leave the party, and I don't think he should."
This is not the first time Sununu has been criticized for allegedly racist remarks this election season.
On Oct. 3, Sununu appeared on MSNBC's Andrea Mitchell Reports to discuss the first presidential debate between Obama and Romney.
When asked about the president's much-derided performance, Sununu said the president was "lazy."
Mitchell asked if he would like to take back the comment, but Sununu refused and reiterated his comment.
"[Obama] didn't want to prepare for this debate. He is lazy and disengaged," Sununu said.
Later that day on Fox News, Sununu was asked if he thought the president would give a better performance in the second debate.
"When you're not that bright, you can't get better prepared," Sununu said.
And in July, Sununu was criticized for telling reporters, "I wish this president would learn how to be an American."
He apologized for those remarks, as well.
"Frankly, I made a mistake. I shouldn't have used those words, and I apologize for using those words," he said on CNN.
Sununu serves as the co-chair of Romney's campaign.
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When it comes to getting in shape, losing the weight is only half the battle. You still have to figure out how to tone and tighten up what's left behind, and the answer may be as simple as changing up your workout.Personal fitness trainer Liane Horne says think about the big picture and work as many muscle groups as you can.At The Wellness Center at DeKalb Medical Center, Horne takes a whole-body approach, challenging her client Margaret -- who's a very fit 69 -- to work as many of her muscles as possible."I try to work large muscle groups first, and so with Margaret, I worked with her legs a lot," said Horne.Horne says it's a mistake to try to tone up one problem area, like your belly, with tons of crunches and sit ups. She says you'll get better results if you focus on building up your overall strength."Where your bending knees, hips, elbows, shoulders, a lot going on," Horne said. "Because, you're going to burn a lot of calories when you're using more muscles at one time."For more defined arms, Horne says work everything from your core up."Chest, shoulders, biceps, triceps, I'll hit forearms. I'll hit every part of the upper body."You don't need to powerlift. Find a weight that's comfortable, but challenging, and do three sets of about 8 to 12 repetitions.If your belly is your problem, you need to focus on burning calories to get your heart rate up. You also need to watch what, and how much, you're eating when you're not at the gym."It's exercise, but it's also diet, being healthy overall," Horne said.If you're trying to lose weight, Horne says the most important thing to remember is you need to burn more calories than you're taking in. The more muscle you have, the easier it is to burn those calories. It's why she recommends a combination of strength training to build muscle and cardio to burn calories.
The FOX Medical Team's Beth Galvin shows us new tactics doctors are trying, to help patients tackle anxiety.
WJBK-TV | Fox 2 16550 West Nine Mile Rd.Southfield, MI 48075Main Station: (248) 557-2000Newsroom: (248) 552-5103


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Ten Things We Learned at the California International Marathon December 08 2011
Soooo....we were responsible for creating the official California International Marathon merchandise this year (This shirt is my favorite). In light of that, the Greenlight team headed to Sacramento over the weekend to man the CIM merchandise booth at the two-day race expo and at the race finish on Sunday morning.
Here's what we learned from the experience...
Mannequins Are Awkward
There is absolutely no way to appropriately wrestle a mannequin into its position on the stand. No matter what you do, your coworker will turn around and lock eyes with you just as you're awkwardly wrangling a pair of running tights onto the damn thing or struggling to lift it up onto its stand, your hands inappropriately placed. Those things are heavy and expensive. Collapsing into a fit of laughter while carrying one can turn disastrous very quickly. I wish I could say we refrained from all manner of juvenile jokes, but I can't because we didn't.
Mirror, Mirror, on the Wall or…You Know, Not at All
So it turns out that when people are trying on shirts, they want to see what they look like. Well, at least prior to running 26.2 miles. After running 26.2 miles, they don't really care about anything other than sitting down. Either way, we totally forgot to bring the mirror. Oops. Sorry, guys, but thanks for taking our word for it when we told you that you looked fabulous. You did, but next time, we'll have a mirror. Promise.
It's Possible to Valet a U-Haul Van
When we finally finish breaking down the merchandise booth at the expo and relocating it to our spot near the finish line, it's close to 9 p.m. on Saturday and everyone is seriously ready for dinner. Circling around downtown Sacramento as we look for parking, Perry and I are in the U-Haul van and Sonny and Monika are driving just ahead of us when they pull to the side of the road.
"Guys, let's just valet the U-Haul," suggests Sonny.
I start laughing because I think he's kidding, but as we pull up to the restaurant and Sonny jumps out to ask the valet guys if they can valet a U-Haul, I realize he's serious which just makes me laugh harder. I'm now pretty much certain that Sonny can convince anyone to do anything because 30 seconds later, we're handing over the keys and walking into the restaurant. What can I say? We like to shake things up.
Sacramento is Cold
We're from the Bay Area. We do fog and drizzle very well, but when it gets below 60, we have problems. Sacramento was "cold." I know all of you who actually live in places where winter isn't just some vague concept are scoffing at the poor Californian who thinks Sacramento is cold, so I'm putting the word in air quotes. Just for you. Seriously though. I actually had to put on a fleece jacket. Can you imagine? It was even colder early Sunday morning while trying to coax race t-shirts onto ice cold hangers with stiff, frozen fingers.
The CIM is Badass
Eight men and twenty-five women qualified for the Olympic Trials, numerous qualifiers for Boston, a marriage proposal at the finish line, and a fireman running with all of his equipment (including the oxygen tank)? That would seal the deal for me right there, but aside from fast runners, superhuman feats, cool costumes, and just being incredibly well organized, the race had a great laid-back feel for such a huge event. They even got the weather gods to cooperate with a perfectly clear and crisp day. Not sure how they swung that one. Sacrifices?
Square is Also Pretty Badass
We've been using the Square application for iPhone. I'm not plugging anything, but that application is pretty awesome and really easy to use. After using it a few times (Apparently, I'm a slow learner), I start getting excited when customers pay with card rather than cash (I'm also a simple soul, easily delighted by new things, cookies, and sparkly objects). When people say, "Wow, that is so cool," I can't help responding, "I know, right?!" Because it totally is.
All Marathon Finish Lines Need Couches
The next booth we have at a marathon, I vote for couches and not just so I can take a nap, although that is a primary factor. After an hour or two of us hopping around trying to keep warm, runners start to trickle in, hobbling unsteadily with tired, but triumphant expressions. It's painful to watch them teetering on spent legs as they try to reach up and grab a t-shirt in their size. I know that despite their enormous grins, their legs are throbbing and every movement elicits protest from trembling muscles. I know this because the last time I ran a marathon, my body was pissed. A couch directly after would have been a nice peace offering.
Grilled Cheese for Breakfast
…is a genius idea. We were conveniently placed next to Drewski's Hot Rod Kitchen food truck (I had nothing to do with that. Honest). Think 9 a.m. is too early for grilled cheese? Think again. That's my new go-to breakfast food.
We're Kind of Hilarious
I laughed a lot this weekend. Not to pat ourselves on the back too much, but in addition to creating awesome racewear, we're also pretty much hilarious. Between the mannequins, the U-Haul valet incident, and trying to figure out how to set up (and break down) Container Store organizers, there was ample opportunity to illustrate how ridiculous and insanely funny we are.
Next year. Hats.
I have no idea how many times runners asked us if we had hats, but it was a lot. Point taken. Next year, we need hats. I'm going to push for the ones with beer can holsters. I'll let you know how that goes.


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I purchased my first font today! Normally I just gaze longingly at them, as they're usually too expensive to justify buying for personal use – but this one was on sale for $9! Take a gander at Thirsty Rough:
I love the old-school, retro style of it. I can see this used in many a project.


text: The use of indoor ceiling fans can reduce prices on your energy costs up to 40% in the summer and 10% in the winter, using only as much as energy as a 100 watt light bulb. During the summer ceiling fans create a "cooling effect" lowering temperatures as much as 7 degrees and recirculating the heat in the winter to the living area. Ceiling Fans are being used now not only in the main rooms in your home but also in kitchens and bathrooms where dampness may be an issue.


text:
A: When you're drinking these... who cares?
Dinner at Schloss Bueker last night, with his homemade chili, cornbread and roast turnips. A lovely, hearty meal and fine company augmented by a couple of lovely reds.
We started with leftovers of a 2001 Selbach-Oster Zeltinger Sonnenuhr Riesling Kabinett that David had opened the prior evening. Absolutely lovely; a core of pure, mineral-tinged citrus, apple and pear fruit that's still very youthful, and just barely accented by the start of developing savoury notes. There's wonderful cut and focus to the flavours, restrained sweetness and stunning balance, and each glass of this disappears all too quickly as this shows a remarkable sense of drinkability and refreshment that I find too rarely in modern Kabinett.
Onto the reds.
1986 Château Beychevelle
First impressions after pulling the cork are of an incredibly tannic, unyielding wine. Four hours after double decanting, this transforms into something much more accessible and fragrant; a combination of dark fruit, tobacco and leathery notes with a savoury earthiness beneath all conveyed on a frame that's surprisingly elegant and finessed for an '86. It's not a big wine - medium weight, polished and initially a little thin on the palate (though it seems to pick up depth and weight with time in the decanter), but really lovely to drink over a few hours.
2007 Pierre Gonon St. Joseph Vieilles Vignes
This still comes across very, very young, but it's nowhere near as impenetrable and unyielding as a bottle I had six months ago. Initially it's rather tight but after about an hour in the decanter it really starts to open out, developing vividly floral and peppery scents around a core of pure dark fruited flavours and faint meaty accents. It's still incredibly primary, but there's a sense of real purity and finesse to the flavours and striking persistence. Beautiful, classical Syrah.
A fun evening as always - thanks again.


text:
Search for
additional physicians or researchers:
- The Johns Hopkins Hospital
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Or find a doctor at another Johns Hopkins Medicine member:
Jonathan Kahn Marx, MD
Appointment Phone
Main Location
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Out of State Patients
Call 410-464-6641 (8a.m. to 6p.m., EST, Mon-Fri)
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Call +1-410-502-0773 (7a.m. to 6p.m., EST, Mon-Fri)
- Assistant Professor of Radiology and Radiological Science
Centers & Institutes
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Chronic Total Occlusions, Claudication, Interventional Radiology, Lower Extremity Angioplasty, Lower Extremity Stenting, Peripheral Arterial Disease, Peripheral Vascular Disease, Renal Artery Disease, Renal Vascular Disease, Varicocele, Vascular and Interventional Radiology, Vascular Malformations, Venous Thromboembolism, Visceral Angioplasty, Visceral Stenting
Research Interests
Interventional radiology; Vascular radiology
Dr. Jonathan K. Marx is an Assistant Professor in the Johns Hopkins Medicine Division of Interventional Radiology within the Department of Radiology and Radiological Science. He is a specialist in vascular and interventional radiology.
Dr. Marx received his medical degree from UMDNJ - Robert Wood Johnson Medical School. He performed a residency in general surgery at Thomas Jefferson University Hospital and another in diagnostic radiology from Morristown Medical Center. He completed a fellowship in interventional radiology at The Johns Hopkins Hospital.
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LocationsThe Johns Hopkins Hospital600 N. Wolfe StreetHospital Main Entrance - Sheikh Zayed TowerBaltimore, MD 21287Appointment Phone: 410-955-6500Location MapJohns Hopkins Outpatient Center601 N. Caroline StreetBaltimore, MD 21287Appointment Phone: 410-955-6500Location MapJohns Hopkins Bayview Medical Center4940 Eastern AvenueBaltimore, MD 21224Phone: 410-550-0214Appointment Phone: 410-550-5731Location Map
- Radiology and Radiological Science - Vascular & Interventional Radiology


text:
|Gaint's Causeway.
|Carrick-a-Rede rope bridge
|Royal Portrush Golf Club
|Bushmills distillery.
|Portstewart Golf Club
|Glens of Antrim
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This modern 'Bed & Breakfast' is just 200 yards from the A8 Larne to Belfast road in a scenic rural situation. It is set in a pleasant garden of over an acre and is just 6 miles from the ferry port of Larne with its many daily crossings to Scotland...
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A beautiful country house close to Bushmills, Giant's Causeway, Carrick-a-rede rope bridge, Dunluce Castle. Spacious rooms with TV, tea/coffee, hairdryers and mini cooler. Warm welcome with tea and home baked bread and jam. Help with information....
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Champagne hot air balloon flights
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Floating Sensations Ltd is one of the longest established Hot Air Balloon Operators in the United Kingdom and the only operator based in Wales. We fly in and around the beautiful Towy valley in Carmarthenshire....
Enjoy the magic of this ancient medieval farmstead
Kent, United Kingdom Birdwatching
Enjoy some peace and quiet in this beautiful farmstead. Explore Darling Buds of May country, with bridleways, fields and hop gardens, then relax in our new contemporary bathrooms. A magical ancient setting, with all the comforts of home....
$137 Per Night/Room
Cooking Tours in Italy
Stoneywood, United Kingdom Cooking Schools
Cooking, painting and pilates holidays in stunning Italian regions offered by Flavours of Italy - delivered by one of the UK's leading specialist tour operators since 1998....
$369 Per Night
Romantic Bronte Country Cottage
York, United Kingdom Health Spas & Retreats
Set in the beautiful Bronte country with stunning views over Haworth and the moors. This 5 Star, White Rose Award finalist, is a wonderful retreat, enjoy the covered hot tub, four poster bed, roll top bath, bespoke kitchen, and log fire....
$100 Per Night
Skye in Focus - photographic holidays on Skye
Isle of Skye, United Kingdom Photography Tours & Workshops
Photography holidays on the Isle of Skye, Scotland. Courses and workshops providing tuition and instruction in the art of landscape photography. Full-board accommodation and darkroom/digital facilities available....
$600 Per Week
Ibiza Holiday
Manchester, United Kingdom Sight-Seeing Tours
Ibiza invasion is responsible to organize holiday and job trips to Ibiza. They are admired and trusted by thousands of their clients all over the world. Based on their contracts and relations in Ibiza, they successfully manage to offer the world's....
Trafalgar Tours, Europe/Egypt from $145 Day!
London, United Kingdom Sight-Seeing Tours
The best of Europe and Egypt from $145 a day, including transportation, daily sightseeing, breakfast, and selected dinners, and the personal concierge services of our professional Tour Directors. Many itineraries available. Call Frosch Travel today!...
Luxury chauffeur-driven tours of the UK
Heart of England, United Kingdom Sight-Seeing Tours
Discover England on a personal chauffeur-driven 7 day tour. Visit The Lake District, The Yorkshire Dales, York, Cambridge, Stratford-upon-Avon, The Cotswolds, Oxford, Stonehenge, Windsor Castle, Perfect for the more discerning traveller....
Starting at 2,050 Per Week
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text: It was a Saturday and I was moping around the house. I had plenty to do but not in the mood to do any of it. I use to say I have never been lonely but lately I have learned what loneliness feels like. I asked myself, "Self, are you having a pity party?"


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In this exclusive new TV ad for Broadway's Annie, see young stars Lilla Crawford, Emily Rosenfeld, Madi Rae DiPietro and more break it down to "It's the Hard Knock Life." Thanks to ad agency Serino/Coyne for the fun video.
Broadway.com is premiering a hilarious new series from the maniacs at Rock of Ages: Drunk Broadway, featuring the cast getting plastered at a bar and talking up your fave shows. First up is The Lion King!September 16, 2014
Talking up Keke Palmer, Sherri Shepherd and Judy Kaye about joining the ball at the Broadway smash Cinderella.September 11, 2014
This week is full of goodbyes, interviews, super fast snack eating and more treats from overseas for James Snyder and the If/Then gang.September 17, 2014
The Book of Mormon Tony Award nominee Andrew Rannells talks about his latest adventure in drag as the star of Hedwig and the Angry Inch.September 12, 2014
James Monroe Iglehart finds himself backstage with a bunch of fellow Broadway stars and they can't help but sing! James also answers your "Ask a Genie" questions backstage at Aladdin.September 11, 2014
Disney has done it again with their new stage adaptation of the animation hit Aladdin! Hear all about the new family favorite from the stars and creators in this video trailer.July 15, 2014
Get ready for an NYC adventure! Check out the stars of the upcoming Broadway revival of On the Town. Find out why this is a classic that sings, dances and can cook too!September 9, 2014
James Monroe Iglehart takes us backstage at Aladdin and asks the cast members to name their favorite Disney movie and song.September 18, 2014
James Snyder helps out with the If/Then ticket lottery and gets a special treat from a very kind German fan.September 9, 2014
The original creators of the Broadway production of Disney's Beauty and the Beast are together again for this new touring production! Get to know the sprightly stars of this enchanting musical, which is making its way across North America!September 16, 2014
September 16, 2014
The Lion KingSeptember 25, 2008


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Keatyn's Q & A
Who's your favorite sports team, and why?
I am an NFL fan along with a College Basketball Fan. So the Tennessee Titans are my NFL Team (I was an NFL cheerleader one season for them) Then as far as college basketball goes I bleed KY BLUE all the way! Go Wildcats!!
What's your favorite movie quote?
"There's no place like home" - Dorothy/THE WIZARD OF OZ
What's your favorite video game, and could you kick our butts at it?
Nintendo Wii: JUST DANCE or TENNIS
Piercings/Tattoos (How many? Where?)
No tattoos, only my ears pierced.
What's the most embarrassing song on your iPod?
Vanilla Ice - "Ice Ice Baby"
What's your best party trick?
Tying a knot in the cherry stem? LOL
What's the most memorable pick-up line you've ever heard?
BEST: "There are hundreds of people in this place yet I have never in my life been more focused on one person than I am you" WORST: "Were you raised on a farm, because you sure know how to raise a cock"
What's the worst job you've ever had?
I've been very fortunate. I've liked all my jobs honestly.
What's the most dangerous thing you've ever done?
Bungee jumping, EEEK! But I want to SKYDIVE.
It's 4AM after a crazy night out – what are we eating?
A combination style tostino's pizza at home.
What's the strangest thing in your fridge right now?
I have like 8 jars of different types of pickles. I was raised as a small town country girl, and I still crave them just as much as I did as a child.
What's the naughtiest thing you've ever done in public?
I don't kiss and tell.
What do you feel sexiest wearing?
Swimsuit or Dukes/Boots/and Tanktop (Cutoff short-shorts are the best!)
Tell us a joke.
If you were a triangle you'd be acute one.


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When you choose to vacation in Alligator Point Florida, you are choosing to get away from it all on Florida's "Forgotten Coast." Less than an hour from Tallahassee, Alligator Point Fla is located on an isolated cape and is less developed than other beach vacation spots.
Rent Alligator Point beach rentals on the Gulf of Mexico for great views of the Alligator Point tides rolling in and out and direct access to the normally warm water. Alligator Point rentals are available with nightly, weekly and monthly rates. Stay at an Alligator Point vacation rental in the off-season for the lowest rates.
The weather in Alligator Point Fl is ideal for fishing and boating. Swimming might be a little too chilly for most in the late fall and winter, but it's good in spring and summer. Normal temperatures are in the mid-70s to low 90s in the summer.
If you brought your own boat, you may be able to tie it up at the Alligator Point marina, though you might need reservations.
Expand your search for Florida vacation rentals to include Miami vacation rentals and Ft. Lauderdale rentals in South Florida, Destin vacation rentals and Siesta Key rentals on the Gulf Coast, or Orlando vacation home rentals near Disney.


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- 100% Leather
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Order By Phone: 00800 6255 3985
Upgrade your look on the course with this sleek Premium Belt Strap, made with 100% genuine leather for durability and style for 18 holes.
Your satisfaction is guaranteed. If you are not satisfied with your purchase, please contact Customer Care for a Return Authorization (RA) number within 14 days of receipt of product. Customized product or product that has been damaged/abused may not be returned under any circumstances. For all other products, if the item is returned in the original packaging, we will provide you a refund based on your original method of payment. The product must be returned to us within 30 calendar days of the issuance of the Return Authorization Number. All products must be packed in the original, unmarked packaging including any accessories, manuals, documentation and registration that was included with the product. Returns that do not meet these conditions may be subject to a restocking fee.
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Spain & Portugal – OEDC, c/o UPS SCS (Spain) SL, Avenida del Sistema Solar, 17, 28830 San Fernando de Henares, Espana
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As Switzerland and Norway are outside of the EU there may be a small delay due to customs import before your return is processed by our central facility in the Netherlands. Please do NOT send returns to the Norwegian or Switzerland address unless you are a resident of that country or it will be returned at your expense, if your country is not listed above please forward directly to our central returns hub in the Netherlands.
Customized products are not returnable or refundable under any circumstances. Your statutory rights are not affected.
All products being returned must have a Return Authorization number in order process a refund. Goods returned without an authorized number may be delayed and/or returned to sender. Product must be returned within 30 days of issuance of Return Authorization number. Original freight charges are not refundable.
You must request a Return Authorization number within 14 days of the date of original invoice. Securely package items as we are not responsible for any items lost or damaged in transit.
The following 'per unit' restocking fees are applied for unauthorized returns or returns outside of the conditions mentioned above; EURO=€5, UK=£5, CHF=SFr 7.50, NOK=45 kr, SEK=50 kr and DKK=40 kr.
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Additional fees will be charged for any product missing the original box, packaging material, contents, accessories, and/or manuals (i.e. any product not in "sellable" condition).
Note: Items purchased from an Authorized Oakley retailer must be returned to the place of purchase.


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Here's everything you need to know about the 2014 World Cup live draw.
Article Comments
(Steve Nehf, The Denver Post)
NFLJacob Tamme ready for call of duty for Broncos
At week's end, Broncos tight end Jacob Tamme wasn't sure of his assignment Sunday, but he'll be ready for whatever duty he's assigned.
Leaking lime juice sends responders to cargo jet
KETCHIKAN, Alaska (AP) — A mysterious liquid leaking on a cargo jet sent emergency responders to the island that is home to the Ketchikan, Alaska, airport.
(Markus Schreiber/AP)
Oculus unveils new prototype VR headset
LOS ANGELES (AP) — Oculus has unveiled a new prototype of its virtual reality headset. However, the VR company still isn't ready to release a consumer edition. Full Story


text:
The Peugeot Fidji Pepper and Salt Mill Set is a sleek design, combining rich wood and stainless steel. Peugeot mills have a unique two-stage grinding process, designed to get the most flavor from every peppercorn. First, the Peugeot pepper grinder cracks the peppercorn. Then it grinds it to the to the size you select. The Peugeot Madras salt grinder resists corrosion because the salt grinding mechanism is made with specially treated stainless steel. The Peugeot pepper mill and salt mill come filled with black peppercorns and sea salt.
Peugeot Fidji 8 inch Black Matte Salt/Pepper Mill Set - SAVE 15% when you buy the set!
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At MetroKitchen.com, you'll find only premium brands of cookware, cutlery, small appliances, wine tools and kitchen accessories.
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Lord's Resistance Army
Stuart Price/AFP Photo
News about Lord's Resistance Army, including commentary and archival articles published in The New York Times.
Chronology of Coverage
Nov. 22, 2013
Speculation has increased that Joseph Kony, elusive Lord's Resistance Army commander, may negotiate his surrender, ending a long, murderous rampage; Kony has been indicted on war crimes and has been hiding in jungles in the Central African Republican. MORE
Apr. 4, 2013
United States offers reward of up to $5 million each for fugitive Ugandan warlord Joseph Kony and some of his top aides in Lord's Resistance Army rebel group; Kony is wanted by International Criminal Court. MORE
Jan. 22, 2013
Ugandan Army announces that its troops in Central African Republic have killed chief bodyguard of Joseph Kony, fugitive leader of Lord's Resistance Army. MORE
May. 14, 2012
Ugandan forces capture Caesar Acellam, senior commander of Joseph Kony's Lord's Resistance Army, after brief fight with rebels near the border between Democratic Republic of Congo and the Central African Republic. MORE
Apr. 30, 2012
One hundred of America's elite Special Operations troops, aided by night vision scopes and satellite imagery, are helping African forces find a wig-wearing, gibberish-speaking fugitive rebel commander named Joseph Kony; he has been hiding out in the jungle for years with a band of child soldiers and a harem of dozens of child brides; no one knows exactly where he is, but over the past few months the American forces, who play an advise and assist role, have helped diminish his ability to direct his 300 or so fighters. MORE
Mar. 24, 2012
African Union plans to launch new operation against the Lord's Resistance Army, Ugandan rebel group led by Joseph Kony that has been terrorizing parts of central Africa for more than 20 years. MORE
Mar. 20, 2012
Ugandan government is scrambling to react to the worldwide attention it has received from the Kony 2012 video, which focuses on the brutality of rebel leader Joseph Kony; officials are mobilizing diplomatic staff members around the world, fearing the video could damage the country's investment climate, but are aware that it could also present investment and tourism opportunities. MORE
Mar. 15, 2012
Nicholas D Kristof Op-Ed column attempts to address some of the criticisms of the 'Kony 2012' YouTube video, which documents the atrocities committed by Lord's Resistance Army leader Joseph Kony; announces the winner of his 2012 win-a-trip contest. MORE
Mar. 10, 2012
Invisible Children's YouTube video Kony 2012 about Ugandan warlord Joseph Kony and his Lord's Resistance Army spurs debate; critics say movie misleads viewers by suggesting that the LRA is still present in Uganda and that the rebel group counts up to 30,000 child soldiers in its ranks. MORE
Mar. 9, 2012
Jason Russell, using social media, has drawn enormous amount of attention to the abuses of Joseph Kony and his Lord's Resistance Army in Uganda; since being posted, Russell's video, KONY 2012, has attracted more than 50 million views and has generated hundreds of thousands of dollars in donations; critics point out that it is not until halfway through the video that it is noted that the war he describes is no longer happening in Uganda, but that it has moved to other, more fragile countries. MORE
Oct. 18, 2011
American officials say most military advisers being sent to Uganda to help track down brutal guerrilla group Lord's Resistance Army will stay in Uganda, which group has not attacked in years. MORE
Oct. 15, 2011
Pres Obama announces the deployment of 100 armed military advisers to central Africa to help regional forces combat the Lord's Resistance Army, notorious renegade group that originated as a Ugandan rebel group in the 1980s and has morphed into a marauding cultlike group of killers and rapists. MORE
There are no additional abstracts to display.
Highlights From the Archives
Foreign Desk
Christian Rebels Wage a War of Terror in Uganda
The Lord's Resistance Army strolled into the village of Palabek one recent morning, a ragged bunch of teen-age boys with machine-guns and machetes.March 5, 1997 worldNews
Under Cover: Photographing Frontline Operations in Africa
The June 15 cover story about confronting terrorism in Africa is accompanied by photographs from Michael Christopher Brown. Here, he discusses his recent assignment for the magazine.
June 13, 2014, Friday
MORE ON LORD'S RESISTANCE ARMY AND: Brown, Michael Christopher , Griswold, Eliza , Congo, Democratic Republic of (Congo-Kinshasa) , Africa , Sudan People's Liberation Army , United States Special Operations Command , Lord's Resistance Army , United States Defense and Military Forces , Photography
African Rebel Leader Said to Be Considering Surrender
There are reports that Joseph Kony, who has been indicted by the International Criminal Court, might be ill and ready to turn himself in.
November 22, 2013, Friday
MORE ON LORD'S RESISTANCE ARMY AND: Child Soldiers , Kony, Joseph , Central African Republic , Uganda , War Crimes, Genocide and Crimes Against Humanity , Lord's Resistance Army , International Criminal Court
Reward Offered for Information on Kony
The United States on Wednesday offered a reward of up to $5 million each for the fugitive Ugandan warlord Joseph Kony and some of his top aides in the Lord's Resistance Army.
April 4, 2013, Thursday
MORE ON LORD'S RESISTANCE ARMY AND: Uganda , Kony, Joseph , State Department , Lord's Resistance Army , War Crimes, Genocide and Crimes Against Humanity
Central African Republic: Troops Kill Rebel Leader's Bodyguard
Ugandan troops in the Central African Republic have killed the chief bodyguard of Joseph Kony, the fugitive leader of the Lord's Resistance Army, a Ugandan Army officer said Monday.
January 22, 2013, Tuesday
MORE ON LORD'S RESISTANCE ARMY AND: Defense and Military Forces , Kony, Joseph , Lord's Resistance Army , Central African Republic , War Crimes, Genocide and Crimes Against Humanity , Uganda
Rebels Are Advancing Toward Capital of Central African Republic
Thousands of civilians fled cities and towns into dense forest as embassies and humanitarian aid organizations evacuated many of their staff members from Bangui.
December 28, 2012, Friday
MORE ON LORD'S RESISTANCE ARMY AND: Bozize, Francois , Central African Republic , Diplomatic Service, Embassies and Consulates , Politics and Government , France , Doctors Without Borders , Lord's Resistance Army , Bokassa, Jean-Bedel
Immense Cache of Smuggled Ivory Is Seized in Malaysia
The authorities found more than 1,000 smuggled tusks hidden in mahogany shipments, in one of the biggest seizures in history.
December 12, 2012, Wednesday
Rebel Officer is Captured by Uganda
A senior commander in Joseph Kony's Lord's Resistance Army was captured in what an analyst called an "intelligence coup" for forces hunting for Mr. Kony.
May 14, 2012, Monday
MORE ON LORD'S RESISTANCE ARMY AND: Uganda , Kony, Joseph , Child Soldiers , Invisible Children , Civil War and Guerrilla Warfare , Lord's Resistance Army , Coups D'Etat and Attempted Coups D'Etat , Acellam, Caesar
In Vast Jungle, U.S. Troops Aid in Search for Kony
A hundred of America's elite Special Operations troops are helping African forces find a wig-wearing, gibberish-speaking rebel commander named Joseph Kony.
April 30, 2012, Monday
MORE ON LORD'S RESISTANCE ARMY AND: Kony, Joseph , United States Defense and Military Forces , Lord's Resistance Army , Fugitives , Central African Republic , Africa , Uganda
From Flash to Fizzle
Today's news culture explodes like fireworks, with each topic a burst of light that appears out of nowhere and disappears just as fast.
April 15, 2012, Sunday
MORE ON LORD'S RESISTANCE ARMY AND: Social Networking (Internet) , Computers and the Internet , Facebook Inc , YouTube.com , News and News Media , Lord's Resistance Army , Google Inc , Komen, Susan G, for the Cure , Kony, Joseph , Web-Original Programming
Sequel to 'Kony 2012' Video Addresses Critics and Outlines Call for Action
Invisible Children released a sequel to its "Kony 2012" viral video on Thursday as part of its campaign calling for the arrest and capture of the African warlord Joseph Kony.
April 5, 2012, Thursday
MORE ON LORD'S RESISTANCE ARMY AND: Invisible Children , Russell, Jason , Kony, Joseph , Lord's Resistance Army , News , Africa , Central African Republic , Uganda
Hope in Uganda
Two weeks after a cease-fire agreement, villagers in Gulu, Uganda, remain scarred but hopeful for peace.
After the Acholi War
The victims of Uganda's Acholi war are desperate to put the nightmarish days behind them.
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Gellar herself or her agent, it a fansite created for
her fans. Please aknowledge the fact that the pictures
available and videos available here are owned by their
respective owners, I do not claim any copyright. Please
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if you want me to remove something.


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Tennis elbow sleeve. 10 long, slip-on style with tapered fit. Features loop-lock tension strap which applies pressure to muscles of the forearm. Blue nylon exterior, black interior, 1/8 neoprene. For size measure elbow joint.
STORE FEATURES: We stock and ship Genuine, new and manufacturer direct products. We don't sell used, expired, knock offs or copies.


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Tony winner Mary Louise Wilson, Gabriel Ebert & more preview Amy Herzog's touching new play 4000 Miles at Lincoln Center Theater's Mitzi E. Newhouse Theatre, where the drama opens April 2.
David Byrne and Fatboy Slim's new musical Here Lies Love is earning acclaim for its world premiere run at the Public Theater—and star Jose Llana dropped by to tell us why audiences are going crazy for it!May 21, 2013
In the final Lion King character study video, South African actor Andile Gumbi brings us behind the scenes as he transforms into the "energetic" Simba. Find out what similarities Prince Simba has to an African warrior.November 13, 2012
Newsies star Corey Cott and the cast reflect on their awesome run at the Nederlander Theatre and give big love to all the Fansies!August 21, 2014
In a very special look at life backstage at If/Then, James Snyder hangs out in the pit, does some work as a Broadway dresser and interviews Idina Menzel. Now that is one awesome vlog!June 6, 2014
Adam Jacobs and Courtney Reed of Aladdin answer a whole new world of questions about their favorite Disney princes and princesses, where they shop and how they stay so buff!July 4, 2014
The Lion King Character Study series kicks off with Patrick R. Brown. Watch how he describes Scar's evil actions, and how his costume and makeup design work to make Scar sharp and unlovable.November 8, 2012
The Fantasticks tells the story of a young boy and girl who fall madly in love at the hands of their meddling fathers, but soon grow restless and stray from one another.July 28, 2009
Melody Yang, one of the stars of off-Broadway's Gazillion Bubble Show, explains how the show transports audiences and the fun ways kids interact with the bubbles.August 13, 2013
This week James Snyder restrings a guitar, does about 7,000 pushups and almost misses his call to places at If/Then.August 8, 2014
The Tony-winning musical The Lion King celebrated 15 years on Broadway with a triumphant performance and lavish celebration. Hear from the award-winning creators and current cast about why The Lion King is unlike any other show on Broadway.November 19, 2012
Before he began performances in The Book of Mormon, Matt Doyle took the stage at Rockwood Music Hall for a one-night-only concert featuring songs from his soulful new album—and we caught all the music from the rock star performance!November 27, 2012
Here, friends, grab a tissue. You'll need it. This is the final episode of The Princess Diary. Get ready to laugh, cry and say goodbye to Laura Osnes, Santino Fontana, dear Herman and everyone at Cinderella on Broadway.January 29, 2014


text: GREETINGS ADMIN ! This site has been Hacked By Best Cracker ! Admin Did you see the protection of your server is low ... Make sure that the protection is created for hackers ' Remember Best Cracker Is here ' "RESPECT OUR RIGHTS, RESPECT OUR FREEDOM" "RESPECT OUR PRIVACY, PROTECT DEMOCRACY" WE are : Best Cracker , HiLl MaN , Golden Boy , Mr Demo = STAR HACKERS TEAM We do it for SYRIA and Palestine We are Muslims And Proud of it We Hate Israel To: Admin patch ur site as soon as possible :) Contact : email@example.com


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Rolex Rankings #5
Rolex Rankings #94
Will Stacy Lewis defend her 2012 title?
Will Shanshan Feng defend her title?
Ernst's victory another big step in her career
The Social Scene for September, 2014
Izzy, a member of the LPGA-USGA Girls Golf, walked around the RR Donnelley LPGA Founders Cup and interviewed players.


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I've heard of Batmanning (hanging precariously from different places by your feet), planking, and Tebowing. But now that just seems boring, right?
I don't necessarily agree with this, but some people thought there needed to be another trend. Enter "Unicorning".
My first question is "What?????" Stick a colored horn on your forehead? Walk around on all fours?? Well, to answer your question, there is an entire website dedicated to just that. Here ya go ... in case you are interested, or just want to observe the craziness.
By Yamavu [GFDL (http://www.gnu.org/copyleft/fdl.html) or CC-BY-2.5 (http://creativecommons.org/licenses/by/2.5)], via Wikimedia Commons


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$29.99 - $39.99
|The Under Armour Translucent Running Jacket leaves heat and sweat in its dust. Signature Fly-By mesh back vents allow for cooling, drying airflow while including stretch elements that won't limit your movement. The super-light woven body is shaped for a semi-fitted look that includes a dropped back hem for extra coverage. The three-piece hood is a low-profile design for sun protection that doesn't distract from your run. HeatGear� fabrics in this jacket perform best from 75-100�. Includes zippered pockets for secure storage and 360� reflective elements. 100% nylon. Mesh insert: 84% polyester/16% spandex. Imported.