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quick linksCURRENT ISSUE PREVIOUS ISSUES NEWS INDUSTRY NEWS COLUMNISTS BROWSE EDITORIAL TOPICS WEBINARS
resourcesABOUT MT AUTHOR GUIDELINES CLASSIFIEDS EDITORIAL CALENDAR MEDIA GUIDE MASSAGE MART SCHOOLS & EDUCATION FEEDBACK
Overcoming Barriers to Exercise Compliance
One of the most common questions other practitioners ask me is, "How do I get patients to do their exercises?" I am not frustrated by my patient compliance, as many doctors are; in fact, I am actually happy with my patients' involvement and commitment.
Defending With Vitamin D: Helps Prevent Progression to Diabetes
A 2014 clinical trial published in the American Journal of Clinical Nutrition provides additional evidence that optimal vitamin D nutritional status may be important in preventing the progression of prediabetes to diabetes in prediabetic adults.
A Guide for Talking to Doctors about Acupuncture and Brain Chemistry
Before I begin any discussion of how to talk about the effects of acupuncture on brain chemistry, nervous and endocrine function, it is essential to understand just what physicians most need help with.
Peer Points: Always Seeking To Grow
Ellen "Kiki" Geary has spent the last decade honing her craft. As a specialist in integrative holistic care, she went straight from completing her master's degree in acupuncture and chinese herbal medicine from Bastyr University to building a successful and thriving practice in the small community of Anacortes, Washington.
State by State: Comparing Chiropractic Scope of Practice
"The issue of 'scope of practice' has been a bugaboo ever since our early quests for legal recognition for chiropractic," according to Dr. Claire Johnson, editor in chief of JMPT and National's other two chiropractic journals.
Love a Nurse – and They'll Love You Back
According to various sources, there are about 3 million registered nurses in the U.S., and according to the American Nurses Association, they are under serious pressure in today's health care reality.
Are Your Work Orders in Order?
There are times when a patient's occupational duties will delay or prevent them from recovering. These circumstances create the need for the doctor to recommend modified duty or remove the patient from work.
We Get Letters & E-Mail
Not All Evidence Is Equal; An Abundance of Misinformation; A Well-Researched Decision; Far Too Dangerous.
Is the EHR Ship Setting Sail Without Us?
The numbers are in: As of July 2014, 10,253 doctors of chiropractic have received $123,059,868 in EHR stimulus funds – and yet that represents less than 15 percent of our profession.
A Dream Come True for Chiropractic: Funding Prevention and Public Health
Back in 2005, Sen. Tom Harkin (D-Iowa) said: "Let's face it, in America today we don't have a health care system, we have a sick care system.
Women's Health: Herbal Formulas to Help Patients With Dysmenorrhea
Chiropractors have long treated women for menstrual pain (dysmenorrhea). Since roughly 60 percent of all chiropractic patients are women and 30-50 percent of women have a history of menstrual cramps, the vast majority of doctors of chiropractic will inevitably see patients with dysmenorrhea.
A History Worth Telling
The popularity and the use of acupuncture for the treatment of animals in the United States is at its peak.
The Art of Day-to-Day Assessment and Treatment: Clinical Pearls
Let's focus on the day-to-day process of assessing and treating the patient. I am proposing a particular attitude; a way of looking at the patient. This often evolves over a few treatments and then changes as you figure out what is significant.
Billing for Same-Visit Extraspinal and Spinal Manipulation
Q: I have always been under the premise that when billing 98943, extraspinal chiropractic manipulation, on the same visit as spinal manipulation, 98940-98942, that the extraspinal manipulation requires modifier 51.
Finders Keepers: The Secret to Relationship-Based Marketing
Becoming a successful practitioner has less to do with what you learned in school, and more to do with your ability to find new patients and keep them!
Medical Qigong for the Heart: Part III
Part 1 and Part II of this series focused on the physical aspect of the Heart and mental emotional aspects of the Heart respectively. Now, I would like to focus on the spiritual aspect of the Heart.
Image Is Everything: The Power of Branding
Successful businesses use color and design to attract people to their service. They understand how important image is and hire experts to create an attractive package. Starbucks works hard to create an atmosphere that is warm and inviting.
The Wisdom of the Second Office Location (SOL)
There are some things I never want to do again, like riding a motorcycle 100 mph. I call these things my "negative bucket list." Other things I have on that list include water skiing, riding a roller coaster and eating habanero peppers.
A Chinese Medicine Story: An Interview with Mazin Al-Khafaji
Mazin Al-Khafaji's work has interested me for years. In February 2014, we invited him for the second time to speak at the Southwest Symposium in Austin, Texas.
News in Brief
Major Organizations Announce Joint Conference; Fighting for Section 2706; New Vice President of Chiro. Program at Parker; Two Families, One Chiropractic Dynasty.
New Medical Technologies You Need to Know
We're all familiar with how fast computers become obsolete, as well as the rapid pace of development in the field of cell phone technology. The latest smart phones are far more powerful than desktop computers were only a few years ago.
July, 2005, Vol. 05, Issue 07
Spa Ratings: Delano Hotel
Rating: 94 Points
By "The Massage Mice"
This periodic article rates the massage/spa experience using the criteria set forth below. The authors, dubbed the "massage mice," are professionals who do not work in the spa or massage industries; instead, they pay full price for all services and do not disclose their intention to rate the spa's services.The opinions of the massage mice do not necessarily reflect those of Massage Today.
Delano Hotel, Miami Beach, Florida - 94 points:
The massage mice received an outstanding in-room massage at the Delano Hotel in Miami Beach, Florida. (When in-room massages are rated, no rating is assigned to the massage room and changing room/waiting area categories. The remaining categories are weighted more heavily for the final result.) The massage was excellent. The massage therapists asked the proper questions, had excellent technique and time allocation, and made good use of pressure. The therapists responded well to feedback from the clients and the therapeutic effect of the massage was felt for a number of days. Reservations were originally botched and required rescheduling. The massage table was excellent and the massage therapist brought soothing music into the room.
Rating Criteria
Meaning of Overall Grades
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Liability Driven Investing Conference
Pensions & Investments' Liability Driven Investing Conference was a big success with hundreds of eager pension plan professionals eager to learn how to successfully implement and manage a LDI strategy in their plan.
Click below to view video interviews with some of the conference speakers to gain additional insights.
For a brief recap of the conference, please visit the "Webinars" page to access the archive of the web seminar that took place on October 17.
The video you requested cannot be found. Please click here to go back to the main video page.

subset: commoncrawl


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Gain access to your Disney Institute courses, quiz results and alumni content.
Though considered a global leader in creativity and groundbreaking entertainment, Disney continues to seek new ideas that will contribute
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Disney insights and illustrations are beneficial to anyone interested in Disney best practices for inspiring greater creativity and innovation for individual employees and entire organizations.
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Disney's Approach to Creativity & Innovation is available in either 1-Day or Multi-Day durations at the Disneyland Resort or in a Multi-Day duration at the Walt Disney World Resort.
*All 1-day courses starting before Dec.31, 2014 can be booked consecutively at packaged rates.
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Now your organization can save when you pre–pay registration fees for multi-day Disney Institute professional development courses. Purchase 5 or more registrations in advance, and you can save on the non–discounted rate for any course in a multi-day duration.*
Prepaid registrations may be used for any multi-day Disney Institute professional development course held only at the Walt Disney World® Resort or Disneyland® Resort. They can be used up to 12 months from date of purchase, giving you a flexible training option that fits within the schedule and needs of your business and your employees.
For more details or to purchase, please call 321.939.4600
Phone: 321.939.4600
(M-F 8:30 am – 6:00 pm ET)
Email: You can also reach us through our Contact Form.
(No solicitors)


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Check your reservation, flight class details and so on; change your seat number.
Check in online or by phone within 24 hours of your departure
Track flight online or via SMS
Order an invoice for ticket purchased on lot.com or in Call Center.
When you organise a meeting with a minimum of 50 participants coming from at least 3 foreign countries, you will have the opportunity of availing yourselves of the Meetings Plus programme. Thanks entirely to our presence within STAR ALLIANCE, the world's largest alliance of airlines, we are able to offer this programme, with its attendant discounts and access to the schedules of the twenty-seven member airlines.
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If you are interested in taking part in the Star Alliance Meeting Plus programme, please complete the following form:
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Say "Thank You" with the ultimate chocolate gift, a Mrs. Prindable's Gourmet Caramel Apple! Each apple is tied with a satin Thank You ribbon. Available in Milk Chocolate Walnut Pecan or Triple Chocolate (shown). Net Wt. Approx. 1.25-1.5 lbs. Serves 8-10.Just how big are these Jumbo apples?
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Kichler Lighting: Whatever your vision or budget may be, Kichler Lighting's leadership in residential lighting design has the indoor light fixtures and outdoor light fixtures for your application. From outdoor lanterns to dazzling chandeliers, Kichler Lighting's trend-setting reputation promises sophisticated world class style and quality. The value to bring your dreams to light and make your house into a home.
Kichler Indoor Light Fixtures
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Kichler Outdoor Light Fixtures
Kichler Lighting outdoor lighting collections consist of lanterns, wall brackets, post mount lanterns, pier mount lanterns and other outdoor light fixtures. A wall-mounted lantern light from the Tularosa outdoor collection is shown at left. Kichler's incredible breadth of styles, finishes and sizes offer multiple aesthetic and functional choices for every application on your property.
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Kichler Landscape lighting including low voltage garden, path and ornamental lighting. Kichler has quality lighting to enhance your outdoor living.
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I've been fine with him going to vegas for the weekend to meet his dad. I was encouraging him to go meet a friend he'd spoken fondly of at a music festival in the fall. If he happened to be in India and wanted to spend some extra time soaking up the culture, I could understand that while being a little jealous.
I am not a controlling person. I have no desire to be in charge of a grown man's decisions.
It is just this particular scenario with this particular person. Someone he's at a tumultuous and sordid relationship with.
And now he's come home with a chip on his shoulder after spending the morning with a local friend. I'm sure his friend has told him how wrong I am to be upset about this and given dbf a little victim treatment. I'm also sure dbf left out a few important details when describing the situation to him.


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Digitisation activities
Recent work examples include:
- 19C British Pamphlets BOPCRIS Ford Collection
- EPPI - Enhanced Parliamentary Papers on Ireland
- From History to Her Story
- Hidden Lives Revealed
- Marandet Plays - University of Warwick
- National Oceanographic Library Digital collections
- Plymouth Medical Society historic collection
- Supporting Assistive Technology
- The Baring Archive
- Thesis digitisation
- University of Southampton - Special Collections Virtual Reading Room
- Winchester School of Art
- The Warburg Institute
Early site of the University of Southampton
Hampshire Sheet LXV N.E. Revision of 1931-32 with additions in 1938
Bartlett music manuscript
The Rev. Bartlett (1788-1841) rector of Swanage - selection from the autograph manuscript
Sung by the Sullivan Singers
19C British Pamphlets
Some of the most significant collections of 19th century pamphlets are held in UK research libraries. 23,000 paper copy pamphlets from seven university libraries were digitised by BOPCRIS (JISC Digitisation Call 2007-2009) and focus on political, economic and social issues. These provide an immensely rich and coherent corpus of primary sources with which to study the socio-political and economic landscape of 19th century Britain. The materials are provided by JSTOR and accessed from the website 19C British Pamphlets Online.
More about
- University of Southampton News Release
- Launch Brochure
- RSLP 19C pamphlets online
- Liverpool launch presentation
EPPI - Enhanced Parliamentary Papers on Ireland
Enhanced Parliamentary Papers on Ireland 1801 - 1922 involved the cataloguing and full-text digitisation of a selection of British Parliamentary papers taken from the University of Southampton's unique Ford Collection of Official Publications. Funding was provided by the Arts and Humanities Research Board (AHRB).
The bibliographic records and searchable PDFs are now available for a large majority of the collection through the University of Southampton Library WebCat. No login is required. We recommend you limit your search by typing 'EPPI' into the keywords plus any other search term(s).
18C British Official Parliamentary Publications
Over 1 million 18th century parliamentary publications were digitised by BOPCRIS under a JISC funded project 2005-2007. The comprehensive collection has been drawn from the University libraries at Southampton and Cambridge and the British Library. Coverage includes the Journals of the House of Commons and Lords, Parliamentary Registers, Sessional Papers of the House of Commons, Acts, Bills and Local and Personal Acts.
Click for web access to the 18th century British Official Parliamentary Publications. Under a JISC agreement, these papers are available free to the UK HE academic community.
More about
BOPCRIS Ford Collection
The Ford selections of British Parliamentary Papers 1801 - 1995 is a finding aid to British Official Publications using a series of printed indexes created by Professor Percy (Peter) Ford (1894-1983) and Dr Grace Ford (1896-1981). The contents of the indexes were integrated into a bibliographic database with additional detailed abstracting and indexing with funding provided by New Opportunities Fund (NOF), Joint Information Systems Committee (JISC). This database has now been incorporated into the University of Southampton Library OPAC.
Plymouth Medical Society historic collection
The Unit undertook the digitisation of original texts for the Plymouth Medical Society and included notes taken by John Clarke in 1781 from Mr Hunter's lectures on surgery.
From History to Her Story
One of the earliest of our digitising projects was created in partnership with West Yorkshire Archive Service. A large paper based resource was compiled into an online site detailing Yorkshire women's lives from 1100 to the present day. The site contains digitised full text documents and teaching materials.
Hidden Lives Revealed
Another project under the NOF programme in association with the Children's Society crated a virtual archive about children in care 1881-1918. The site contains photographs, a database of children's homes with links to related full-text case file documents about children in those homes, activities, articles and learning materials.
Supporting Assistive Technology
Assistive Technology is a new and growing area for us and we are able to offer scans for text readers and braille under the sanction of the CLA.


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HIV Drugs Show Promise Fighting Cancer in Preclinical Studies
Results published in the September 1 Clinical Cancer Research showed that three of six drugs used to treat HIV/AIDS also inhibit an important target in cancer, Akt, stopping the growth of cancer cells, not only in vitro, but also when those cells are transplanted into mice. Read more
Creating a Bridge to Success
Improving the translation of promising laboratory findings into the clinic is a top NCI priority. One of the most important mechanisms by which NCI helps bring new interventions to patients and clinicians is the Small Business Innovation Research (SBIR) program, which was created by Congress to strengthen the role of small, innovative companies in federally supported research and development.
Traditionally, venture capital firms, larger pharmaceutical and biotechnology companies, and other private investors have provided the investments that these small businesses needed to advance a product through the stages of commercial development. Over the past decade, however, small businesses have struggled to secure such funding. It has been reported that last year only 5 to 6 percent of biomedical deals into which U.S. venture capital firms entered were with companies in the formative stages. Read more
HIV Drugs Show Promise Fighting Cancer in Preclinical Studies
NCI investigators have shown that nelfinavir (Viracept) and two other protease inhibitors, drugs developed and approved to fight HIV infection, may have a role in treating cancer. The research illustrates the promising strategy of broadening the use of these inhibitors that have already shown efficacy against HIV/AIDS to include cancer treatment.
Results published in the September 1 Clinical Cancer Research showed that three of six drugs used to treat HIV/AIDS also inhibit an important target in cancer, Akt, stopping the growth of cancer cells, not only in vitro, but also when those cells are transplanted into mice.
These results have encouraged Dr. Phillip Dennis, whose laboratory in the Medical Oncology Branch of NCI's Center for Cancer Research (CCR) conducted the study, to begin a phase I trial, testing nelfinavir in people with a wide range of solid tumors that have progressed after treatment with standard therapies.
"Based on the in vitro work, we're hopeful that giving patients larger doses of nelfinavir than are used to treat HIV will be effective against their cancers," said Dr. Dennis. In phase I trials, researchers are determining how much of the drug can be safely given - the maximum tolerated dose - and how the drug actually works in the body.
At the same time, a phase I/II study testing nelfinavir in patients with liposarcoma is also underway.
To determine whether a group of protease inhibitors presently FDA-approved for treating HIV/AIDS also might be applicable to cancer, Dr. Dennis' team performed a number of experiments with cell cultures and tumor-bearing mice. First, the researchers found that nelfinavir was most potent against a panel of non-small-cell lung cancer lines. Second, in the NCI60 panel of cell lines drawn from nine different types of cancer, three HIV protease inhibitors inhibited cell growth. Nelfinavir was again most potent, showing activity against all cancer types tested. In mice, nelfinavir inhibited the growth of two types of lung cancers.
"We're not convinced that Akt is the critical target of nelfinavir therapy because the effect on that pathway is transient," said Dr. Dennis. "But we were able to show with biomarkers that this treatment impacts tumor growth, in part by inducing apoptosis," the normal process of programmed cell death to eliminate old or damaged cells.
The scientists made an interesting discovery about nelfinavir. When tumor cells in mice were treated with this protease inhibitor, some cells that did not die by apoptosis still died by a nonapoptotic process. Drug treatment put stress on the endoplasmic reticulum (ER), the part of a cell where proteins are made, which triggered a process known as autophagy in which cells under stress digest themselves.
ER stress and autophagy are cellular processes that are gaining importance in cancer research because researchers suspect that impaired autophagy may contribute to cancer development. Markers of ER stress and autophagy will be useful for studying nelfinavir in clinical trials for cancer patients.
"The need for expedited development of effective cancer therapies is critical," said Dr. Dennis. "Repositioning drugs that are already FDA-approved for use in patients could greatly accelerate the development of new cancer therapies. Our data suggest that, given its wide spectrum of activity, nelfinavir could be successfully repositioned as a cancer therapeutic."
— Addison Greenwood
Creating a Bridge to Success
Improving the translation of promising laboratory findings into the clinic is a top NCI priority. One of the most important mechanisms by which NCI helps bring new interventions to patients and clinicians is the Small Business Innovation Research (SBIR) program, which was created by Congress to strengthen the role of small, innovative companies in federally supported research and development.
Traditionally, venture capital firms, larger pharmaceutical and biotechnology companies, and other private investors have provided the investments that these small businesses needed to advance a product through the stages of commercial development. Over the past decade, however, small businesses have struggled to secure such funding. It has been reported that last year only 5 to 6 percent of biomedical deals into which U.S. venture capital firms entered were with companies in the formative stages.
This reluctance has only exacerbated the difficulty small businesses have in bridging what has come to be known as the "valley of death": the period between the basic and preclinical work that produces a potentially promising new intervention and the later-stage research and development, including phase I and II clinical trials, that will determine whether that intervention reaches the market.
This dearth of funding and support has stalled or greatly delayed development of many potentially important new products. Recognizing the negative impact of this trend on patients, NCI is implementing a targeted strategy to help small businesses through the valley of death.
First, we are creating new "SBIR Phase II Bridge Awards" intended to both provide and attract funding to help companies during this transition period.
To qualify for these awards, which are modeled on a National Science Foundation (NSF) program, the small business must secure matching private funds. Because NCI will be sharing in the financial risks of the technology development, we believe these awards will attract both private investors and strategic partners - relationships critical to the ultimate success of the small business. In fact, in a recent NSF study of their program, the commercialization success rate for SBIR Phase IIB awardees was more than double that of those firms who had only received a Phase II award.
NIH Director Dr. Elias Zerhouni asked NCI to lead an effort to find ways to optimize the NIH SBIR program. As a result of this evaluation, we are continuing to lead an implementation plan by consolidating management of all NCI SBIR grants and contracts into a new organization called the SBIR Development Center. This organization also will function as a service center to other ICs, providing support in the areas of business development, market research and analysis, and targeted outreach to small businesses eligible to participate in the SBIR program. Through these services, NCI will continue to provide leadership and generate trans-NIH support in driving important new initiatives that will enhance the success of the NIH SBIR program. Development Center project managers will work with small businesses receiving SBIR funds to assist with commercialization strategies, establish milestones, and identify strategic partners. We are recruiting staff with both scientific expertise and experience in the private sector managing technology development through different research phases and planning for commercialization. Michael Weingarten from my staff, who has led the effort to develop new strategies for enhancing the SBIR program, will head this new center.
Third, we are relying more on contracts to spur the development of technologies or interventions in high-priority areas. Historically, more than 90 percent of SBIR funds have been awarded as grants. Over the last 2 years, however, SBIR has been transitioning toward more contracts for technologies NCI would like to see developed that are specifically relevant to cancer research. This year, we have identified 16 technology areas for which contract solicitations were just announced - contracts that will have specific deliverables and milestones to ensure we are getting the most from our investment.
We have implemented an aggressive effort to market the SBIR program at industry, technology, and drug development meetings and events. By reaching out to leaders in the small business community, we will encourage them to compete for these contracts and increase the quality of applicants.
These changes to the SBIR program are intended to enhance innovation and address the gaps in the development pipeline, and it's our belief that patients will be the ultimate benefactors.
Dr. John E. Niederhuber
Finasteride Not Linked to High-Grade Prostate Cancers
In 2003, the NCI-sponsored Prostate Cancer Prevention Trial (PCPT) found that finasteride reduced the overall incidence of prostate cancer by 25 percent, but was associated with a small increase in the number of high-grade cancers, which are often aggressive. It was not known whether the drug caused more high-grade prostate cancers or merely facilitated their detection. The new studies suggest the latter.
In the first study, Dr. Yael Cohen of Gamida Cell in Jerusalem and colleagues determined that finasteride reduces the volume of the prostate and therefore increases the likelihood of finding high-grade cancer cells in a biopsy. Finasteride accelerates the detection of high-grade cancer yet may not promote its development, they conclude.
The second study analyzed prostatectomies from the PCPT and found that the relative increase in high-grade tumors in the finasteride group was less than originally believed. The findings further suggest that enhanced detection may have contributed to the increase in high-grade disease in the finasteride group, reported a team led by Dr. M. Scott Lucia of the University of Colorado Health Sciences Center.
More Americans Getting Cancer Information from the Internet
For a growing number of Americans seeking information about cancer, the Internet remains a frequent first source, even though the public's trust in online material may be on the decline, reports a government study.
The report, Cancer Communication: Health Information National Trends Survey 2003 and 2005, is based on data from the Health Information National Trends Survey (HINTS), a biennial survey sponsored by NCI's Division of Cancer Control and Population Sciences (DCCPS). First conducted in 2003, HINTS surveys the U.S. civilian adult population to assess trends in the use of health information over time and to study the links between cancer-related communication, knowledge, attitudes, and behavior.
In 2003, 44.9 percent of HINTS respondents reported looking for cancer information for themselves on the Internet; in 2005, 48.7 percent of respondents reported looking for cancer information for themselves online. In addition, in 2003, 23.9 percent of respondents reported "a lot" of trust in health information from the Internet, while this number was somewhat lower in 2005 (18.9 percent). Health care professionals were most frequently identified as a trusted source of information in both 2003 (62.4 percent) and 2005 (67.2 percent).
"The survey is not only a surveillance tool, but can be used to study relationships of how knowledge about health care is dependent on channels of communication," said NCI researcher Dr. Bradford Hesse. The researchers also looked at population estimates of cancer knowledge and beliefs, and worked with statisticians and geographic information systems specialists to create maps to portray regional geographic variation, much like weather maps.
The HINTS report is available at: http://hints.cancer.gov/hints/.
Racial Differences in Breast Tumors May Reflect Biology
A large study confirms recent reports that African American women are more likely than white women to have breast tumors that are estrogen receptor (ER)-negative, which are often aggressive and do not respond to antiestrogen therapies such as tamoxifen. A primary reason for the racial differences may be biological, researchers reported at the 2007 Breast Cancer Symposium in San Francisco.
African American women are more likely to die of breast cancer than white women, even though they are less likely to develop the disease. Lack of access to care and other factors are thought to contribute to the disparity. The new study suggests a role for biology: More aggressive tumors were found to be more common in black women than white women in all stages of disease and in each age category, even among women over age 80.
This study differs from previous reports mainly in its larger scale. Dr. M. Catherine Lee of the University of Michigan Comprehensive Cancer Center and her colleagues analyzed 170,000 cases of breast cancer in the National Cancer Data Base, a tumor registry that collects cancer data from more than 1,400 hospitals in all 50 states and Puerto Rico.
For women with invasive cancers, ER-negative tumors were significantly more common in African American women: 39 percent of black women had ER-negative tumors, compared with 22 percent of white women. Black women were also diagnosed at a younger average age (57 for black women vs. 62 for white women) and at a later stage than white women.
Hypnosis before Breast Cancer Surgery Reduces Pain, Cost
Women who received a brief hypnosis intervention before breast cancer surgery spent less time in the operating room and reported significantly less pain and discomfort after surgery than women who did not undergo hypnosis, reports a study published in the September 5 JNCI.
Investigators at Mount Sinai School of Medicine randomly assigned 200 women scheduled to undergo surgical breast biopsy or lumpectomy to either a hypnosis group or a control group. Women in the hypnosis group received a scripted 15-minute hypnosis session within 1 hour of surgery from psychologists trained in the use of hypnosis in the medical setting. Women in the control group spent an equal amount of time with the psychologists within an hour of surgery to talk and receive emotional support.
Because the women knew their group assignment, the investigators took several precautions to reduce potential bias, including blinding anesthesiologists and surgeons to the group assignments and using research assistants unaware of the group assignments to collect the women's perception of pain and discomfort.
Women in the hypnosis group required significantly less of the anesthetic propofol and the analgesic lidocaine, the doses of which are adjusted for individual patients during surgery. Although use of pain medication after surgery did not differ between groups, women in the hypnosis group reported significantly less pain intensity, pain unpleasantness, nausea, fatigue, discomfort, and emotional upset.
Women in the hypnosis group also spent about 10 and a half fewer minutes in surgery. On average, the surgical procedures cost about $770 less per patient in the hypnosis group, mostly due to reduced time in surgery.
Another Role for microRNAs: Suppressing Tumors
A number of recent studies have suggested that microRNAs are involved in suppressing tumors. These small RNA molecules, which regulate the activity of multiple genes, are increasingly recognized as important players in cell signaling.
The studies found that a family of three microRNA genes - the miR-34 family - is switched on by the tumor-suppressor gene p53 in response to DNA damage and cellular stress. The studies come to the same conclusion: microRNAs are an important component of the p53 network, and their loss may contribute to some cancers.
The most recent study, in the August 7 Current Biology, reported that the activity of two miR-34 genes was often compromised in human lung cancer. The genes were much less active than normal in 6 of 14 non-small-cell lung cancers that the researchers examined. Experiments in cells and mice showed that restoring the missing gene activity prevented some abnormal cell growth.
"These findings add one more piece to the p53 puzzle," says lead researcher Dr. Guido Bommer of the University of Michigan School of Medicine. "p53 is the major player in responding to DNA damage or other potentially harmful cellular stress, and we believe these microRNAs mediate a significant part of p53's function."
The results confirm other recent studies, including two in the June 8 Molecular Cell. One team reported that miR-34a is commonly deleted in human cancers and frequently absent in pancreatic cancer cells, while another found that in the absence of miR-34a, cells may not initiate p53-mediated cell death and thereby avoid progressing to cancer.
Finally, a report in the June 28 Nature found that miR-34 genes may play a role in causing cell death as well as inducing a state of growth arrest that normally occurs when cancer genes are activated accidentally.
Ovary Removal Linked to Cognitive Problems, Dementia
Women who had one or both ovaries removed before menopause for noncancer reasons faced an increased risk of developing cognitive problems or dementia later in life, according to a new study. But women who underwent estrogen replacement therapy until at least age 50 after having their ovaries removed were not at increased risk. The study supports the hypothesis that there may be a "critical age window for the protective effects of estrogen on the brain," the researchers write in the September 11 issue of Neurology.
The study included nearly 3,000 women, who were followed for more than 25 years. Dr. Walter Rocca of the Mayo Clinic and his colleagues studied 813 women who had 1 ovary removed, 676 women who had both ovaries removed, and a comparison group of women who did not have their ovaries removed when the study began. About half the women had their ovaries removed because of a benign condition, such as cysts or inflammation; the others had their ovaries removed prophylactically to prevent ovarian cancer. Women who had the procedure for ovarian cancer or another estrogen-related cancer (usually breast cancer) were excluded because of their high risk of death shortly after surgery.
The researchers suggest three possible mechanisms to explain the association they observed. First, ovary removal may cause an estrogen deficiency that initiates biological changes leading to the elevated risk. Second, the association may involve a deficit of progesterone or testosterone rather than estrogen secreted by the ovaries. Third, the association may be caused by susceptibility genes that independently increase both the risk of ovary removal and cognitive impairment or dementia.
The study's strengths include the long follow-up and the fact that the women were representative of the general population. Its limitations include the use of telephone interviews to assess cognitive abilities and an overall interview participation rate of 62 percent. In addition, the surgeries were done between 1950 and 1987, when surgical practices and estrogen use may have differed from today.
Nevertheless, the findings should lead to a reassessment of prophylactic removal of the ovaries in premenopausal women and of the use of estrogen treatment following ovary removal, the researchers say. "The results of this study are important for the majority of women who do not have an increased risk of ovarian cancer," says Dr. Rocca. "Women should consult with their physicians when considering the risks and benefits of prophylactic removal of the ovaries, and when considering treatment afterwards."
Genes and Environment Initiative Announces First Grants
NIH has selected the first projects to be funded as part of the Genes, Environment and Health Initiative (GEI), a unique collaboration between geneticists and environmental scientists. To identify genetic risks, researchers will use the rapidly evolving technologies used in genome-wide association studies to focus on common conditions, such as tooth decay, heart disease, cancer, and diabetes. The environmental component will begin by developing new technologies that accurately measure personal exposures with small, wearable sensors that can be used to assess environmental agents. The final component of the research strategy is to determine whether the effect of genetic variants that increase disease risk is different in the presence of environmental exposures.
In the first year, NIH will fund 8 genome-wide association studies, 2 genotyping centers, a coordinating center, and more than 30 environmental technology projects. NCI's DCCPS is the lead agency for the "Improved Measures of Diet and Physical Activity" component of the initiative.
Decision Aids Give Patients More Say in their Cancer Care
Recently, interactive programs have become available in print and online to help patients take a more active role in their health care, from choosing a treatment plan with their physician, to identifying late effects and follow-up care after treatment ends.
Tools such as these are an attempt to address shortfalls of the U.S. health care system, many of which were outlined in a recent Institute of Medicine report. By enabling patients to communicate effectively with their providers about the benefits and risks of cancer treatment, as well as the possible consequences that should be monitored, these tools could be a helpful cancer care supplement.
One such tool published online this past July, called OncoLife, was developed by a team of oncology nurses and physicians from OncoLink.org, the Web-based cancer resource of the Abramson Cancer Center of the University of Pennsylvania. Using a computer, patients or clinicians can check boxes and select options from drop-down menus according to type of cancer and treatments received. The program generates a summary of the possible treatment side effects - secondary cancers, bone-density loss, infertility, and cognitive problems, for example - which is called a Survivorship Care Plan.
OncoLife tracks information about its users so that the system can evolve according to their needs, as well as with the latest updates to treatment information, explains Dr. Metz, who notes that the first update to OncoLife is expected in the next few months.
"We are seeing a 'perfect storm' in health care that is going to drive increased demand for these technologies," says Dr. Brad Hesse, chief of NCI's Health Communications and Informatics Research Branch. The advent of widespread electronic health records and a predicted surge toward direct-to-consumer marketing of health care are all moving Americans toward a do-it-yourself attitude, he explains.
Research also supports the concept of patients becoming more actively involved in decisions about their cancer care. Several studies with breast cancer patients, for example, have shown that when a woman was involved in the decisions surrounding her treatment plan, she was more likely to be satisfied with the result and with her life than if she had not been involved in the decision. This was regardless of the treatment she received or her outcome in the years that followed.
There are some concerns, though, with a possible lack of human interaction when patients begin to rely upon decision tools. The most recent data from NCI's Health Information National Trends Survey (HINTS) show an increasing preference for health information that comes directly from a person, rather than from an inanimate source such as online or on paper.
"We are living in a new world where patients and survivors are expected to take greater responsibility for their health, and we're not all comfortable with that," says Dr. Julia Rowland of NCI's Office of Cancer Survivorship. "Some older cancer survivors, and those from different cultural backgrounds, for example, are more comfortable with a more paternalistic model of care; they expect their doctors to be the key decision makers when it comes to choices in their cancer care," she explains.
Low literacy and low numeracy - that is, what numbers associated with risk, such as percentages and "chances," really mean - are other factors that could render otherwise helpful information useless, or possibly alarming, in unattended hands. For this reason, the IOM report recommends that health care professionals review survivorship care plans with patients during a formal discharge consultation.
Dr. Wendy Nelson, a program director in NCI's Basic and Biobehavioral Research Program, notes that NCI is funding several projects to examine how technology can help patients access and understand health information. "Decision aids are not a panacea," she says. "They have the potential to be useful adjuncts for patient-physician decision making. However, we still have a lot to learn about how decision aids work and how they are being used, even as we develop them."
— Brittany Moya del Pino
HIV Protease Inhibitor Therapy for Liposarcoma
Name of the Trial
Principal Investigator
Why This Trial Is Important
Nelfinavir, a drug used in the treatment of human immunodeficiency virus (HIV) infection, may be able to help stop the growth of liposarcoma. Nelfinavir is a protease inhibitor, a type of drug that interferes with the ability of certain enzymes (proteases) to break down proteins, which is a process that is necessary for some cells and viruses to reproduce.
In HIV-infected patients, nelfinavir often interferes with the growth of fat cells. This characteristic led researchers to test the drug on liposarcoma cells in the laboratory. The research showed that nelfinavir slowed the growth of liposarcoma cells and caused them to undergo apoptosis (programmed cell death).
In this trial, researchers will test nelfinavir in patients with advanced liposarcoma to see if it helps shrink their tumors. They will also seek to establish the drug's maximum tolerated dose and its pharmacokinetics (fate of the drug in the body) in these patients.
"Currently, we don't have very many options available to treat liposarcoma that recurs or metastasizes," said Dr. Chow. "We need to develop a new therapy that targets the key molecular pathways of this cancer. Nelfinavir is a drug that is already FDA approved and has shown promise in laboratory tests, and so we hope to see evidence of clinical activity in this trial."
Who Can Join This Trial
Study Site and Contact Information
An archive of "Featured Clinical Trial" columns is available at http://cancer.gov/clinicaltrials/ft-all-featured-trials.
Following are newly released NCI research funding opportunities:
Bioengineering Approaches to Energy Balance and Obesity
Application Receipt Dates: Non-AIDS Applications (new): Feb. 5, June 5, and Oct. 5, 2008; Feb. 5, June 5, and Oct. 5, 2009; Feb. 5 and June 5, 2010.
This is a renewal of PA-06-055 and PA-06-056 and will use the R43/44 and R41/42 award mechanisms. For more information, see http://cri.nci.nih.gov/4abst.cfm?initiativeparfa_id=3765. Inquiries: Dr. Sharon Ross - firstname.lastname@example.com.
International Cooperative Biodiversity Groups (ICBG)
Letter of Intent Receipt Date: Nov. 6, 2007.
This is a continuation of RFA-TW-04-004 and will use the U01 award mechanism. For more information, see http://cri.nci.nih.gov/4abst.cfm?initiativeparfa_id=3769. Inquiries: Dr. Yali Fu - firstname.lastname@example.com.
Advanced Genomic Data Analysis and Visualization Methods for the Cancer Genome Atlas Data
Letter of Intent Receipt Date: Nov. 10, 2007.
This funding opportunity will use the R21 award mechanism. For more information, see http://cri.nci.nih.gov/4abst.cfm?initiativeparfa_id=3768. Inquiries: Dr. Daniela S. Gerhard - email@example.com
If Memory Serves...
When the United States entered World War II, many laboratory and animal technicians enlisted or were drafted into the Armed Forces. Many of these technicians had originally obtained their jobs through the Works Progress Administration. (Read more)
For more information about the birth of NCI, go to http://www.cancer.gov/
The NIH Director's Pioneer Awards Symposium will be held on September 19 in the Natcher Conference Center on the NIH campus in Bethesda, MD. The meeting will feature the announcements of the 2007 Pioneer Award recipients and presentations by the 2006 winners.
Part of the NIH Roadmap for Medical Research, the NIH Director's Pioneer Award (NDPA) Program is a high-risk research initiative of the Research Teams of the Future theme. First announced in FY 2004, 9 awards were made in September 2004, and 13 awards each were made in 2005 and 2006. NDPA is designed to support individual scientists of exceptional creativity who propose pioneering approaches to major challenges in biomedical and behavioral research. The term "pioneering" is used to describe highly innovative and potentially transformative approaches with the potential to produce an unusually high impact, and the term "award" refers to a grant for conducting research, rather than a reward for past achievements. Additional information about the Pioneer Awards and the symposium is available at http://nihroadmap.nih.gov/pioneer/index.aspx.
NCAB Meeting Slated for September 17 & 18
HIV/AIDS Research Symposium Set for November
Biomarkers Meeting in Brussels
The purposes of this meeting are to accelerate progress in the fight against cancer and to improve international scientific collaboration between Europe and the United States in the rapidly advancing field of cancer markers.
This meeting will bring together clinicians, pathologists, laboratory scientists, statisticians, and representatives from the pharmaceutical industry as well as regulatory agencies. A tutorial open to selected young oncologists and representatives from the pharmaceutical industry will take place before the meeting, on November 14. Additional information is available at http://www.eortc.be/seminar/enasco2007/default.htm.
Online Resource To Help Medical Responders During Radiation Emergencies
Six years ago today, the terrorist attacks on America triggered a mobilization of national defense, preparedness, and resources that has no historical blueprint to follow. Plans to counter one of the most menacing threats - radiation contamination by nuclear explosion, "dirty" bomb, or some other device - have been developed with the help of NCI experts in radiation medicine.
The medical community around the globe has learned a great deal about how best to respond when people are exposed to radiation, based on decades of clinical experience with mass casualty radiation events: the atomic bombs dropped on Hiroshima and Nagasaki, nuclear reactor accidents such as Three Mile Island and Chernobyl, and accidental exposures during the transport of radioactive material.
The dilemma is that such knowledge resides primarily among experts and specialists, of which there are a limited number, and these experts may be especially scarce if the emergency were catastrophic and widespread. Also, the rarity of such an event means that up-to-date information is the optimal solution for health care providers.
This potential disconnect is addressed by Radiation Event Medical Management (REMM), a new Web site developed by planners, physicians, radiation specialists, and other subject matter experts working with the Office of the Assistant Secretary for Preparedness and Response (ASPR) in the U.S. Department of Health and Human Services (HHS) in collaboration with the National Library of Medicine (NLM). The Web site was originally conceptualized by experts from NCI, ASPR, and NLM and the unique system was created by Dr. Judith Bader of NCI and a team from NLM (led by Florence Chang and colleagues).
Several of the key personnel on this project are on detail from NCI, including team leader Dr. Norman Coleman of NCI's Radiation Research Program in the Division of Cancer Treatment and Diagnosis.
"REMM was established to provide just-in-time information and guidance on diagnosis and treatment to health care providers - primarily physicians - who do not have formal radiation medicine expertise," explains Dr. Coleman.
He emphasizes that REMM is just one piece of the large government network being assembled by HHS and the Department of Homeland Security. Dr. Coleman and the REMM team are part of the Office of Preparedness and Emergency Operations (OPEO). Rear Admiral W. Craig Vanderwagen is the assistant secretary for preparedness and response; the OPEO team is led by Drs. Kevin Yeskey and Ann Knebel. In OPEO, they plan for the unthinkable regarding chemical, biological, radiological, and nuclear events and scenarios, as well as planning for natural disasters.
Part of REMM's solution to this challenge is a series of decision-tree algorithms for the nonexpert physician to follow at the scene. Because access to the Internet may be compromised during an emergency, the core of REMM also comes in the form of a diagnostic and treatment toolkit that can be downloaded in advance and stored on a local computer or storage device.
For REMM, the expert NLM content team gathered guidelines, protocols, procedures, and background from scores of sources, inside and outside of the federal government, and from scientific sources abroad. The initial Web site was reviewed by some 50 subject specialists from around the world and continues to be enhanced.
— Addison Greenwood


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A high school community is in shock after a popular coach was gunned down in cold blood. Students and staff at Cody High said Coach Charles Knott was dedicated to helping young people succeed. So why would anyone want to kill him?"Basically everything I know, I learned from Coach Knott," said Shatona Clark."He just gave that automatic love for the kids," said Calvin Norman, Cody High School's football coach.When you find someone who has a true passion, a calling to help young people reach their potential, you never want to let them go. That is how so many people feel about 54-year-old Charles Knott."A father, he was a coach, role model," Clark said."The girls really walked around school with a lot of pride. That's something that I didn't see before until he came along," Norman said.Knott was the girl's basketball coach at Cody and called the school his second home for more than 20 years."The tone was real intense. The kids [were] very emotional today," Norman said.Late Tuesday night, we're told Coach Knott was parked outside his apartment complex on the city's west side when he was approached by someone in a Jeep who pointed a gun at him and then pulled the trigger."He was gunned down, shot multiple times to death, left there to die," Clark said.Friends said Knott had also been robbed."They say time heals all wounds. At this point, I don't even know how because I don't even know how I can move on because it's so devastating," Clark said. "He was like a dad to me."His compassion extended well beyond his players."Players' families and players' neighbors and neighborhoods and everything," Clark said."A real quiet, smooth, subdued guy. Even when he spoke, he spoke in a calm, humble-type voice. I never really [saw] him get upset. He had integrity," Norman said. "He was a great guy, and I miss him already."Grief counselors were on hand for anyone who needed to talk. Coach Knott had recently retired, and everyone knew things would never be the same, but they did know they would see him around again helping people like he always did. It's sad to know now that won't be the case.
WJBK-TV | Fox 2 16550 West Nine Mile Rd.Southfield, MI 48075Main Station: (248) 557-2000Newsroom: (248) 552-5103


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Symptoms of Valley Fever in Dogs
Symptoms of this fungal disease are not always easy to recognize
Please note comments are moderated. After being approved your comment will appear below.
Submitted by Janice Arenofsky | April 19 2010 | Permalink
Although Shannon Fitzgerald got most of her information right, she should have spoken to Lisa Shubitz, DVM, at the Valley Fever Center for Excellence in Tucson. Lisa probably would have told her that many more dogs than people wind up with the disseminated version of Valley Fever. Many dogs die of Valley Fever or complications from it, so the scenario is not quite as cheery as Ms. Fitzgerald indicates. Her story of Hunter while inspiring, is far from typical. Many dogs cannot tolerate fluconazole, which merely remits the disease at best, and others wind up with kidney disease as a result of the antifungal drugs. As Ms. Fitzgerald correctly asserted, there is no cure yet for the disease, and it can come back at any time. Also, the test is far from accurate, often yielding false negatives.
I've lived in Phoenix for 30 years, and Arizona, where 80 percent of cases of coccidioidomycosis occur each year, has yet to invest any great sums of money on a curative pharmaceutical agent, much less a vaccine. A vaccine is easily 10 years and millions of dollars away--Valley Fever is an orphan disease that triggers no interest from pharmaceutical companies who know there won't be enough of a market for them to make a sizeable profit. Our best hope, at this point, is nikkomycin Z, which is in the midst of FDA testing. But even if that succeeds in curing the disease, it's at least five years away from being on your medicine shelf.
If Shannon lived in Arizona, she'd worry 100 times more about dogs getting Valley Fever than about dogs getting substandard food content.
Submitted by magicmutts | August 26 2011 | Permalink
What Shannon had to say was informative, however, I also believe she did not go far enough.
Submitted by Lew | August 22 2012 | Permalink
For all of you who are desperate to see your canines well again please read my story.
Submitted by Debo | May 29 2013 | Permalink
I need to know what kind of fungus or disease you are referring too when you say there is a similar disease too V.F in the black soil in ontario. I have a press canario who is very sick and has all the xtreme symptoms of vally fever . We coincidenty live on 8 acres of black loam soil in southern ontario . Please reply
Submitted by Michele | September 3 2013 | Permalink
What is the name of the disease your dog had from Ontario Canada? Our dog visited Canada and shortly after came down with Valley Fever. Am having a hard time believing it is Valley Fever since none of our other dogs came down with it only the one who went to Canada. We visited Alberta not Ontario but worth asking you. Thank you
Submitted by Lori | December 30 2012 | Permalink
My dog has valley fever, I believe that she and I contracted it at the same time. I used to run in the canals in Tempe. Before she was a year old, she started walking as if she had paid in her hips, as if she were 10 years old. My vet confirmed with a blood test. I put her on valley fever medication, together with asprin and glucosomine. After 6 years, she has finally beat it, with a level of 0 - 4. My mistake was not seeing the doctor after the first round of meds ran out. I did not take her back right away and her symptoms reappeared. So, this is not something to take lightly, it is serious and may require long term care. My dog is a brindle pit mix and very healthy and happy now. I still give her glucosomine and sometimes asprin as her hips still get sore. She is able to run and play and jumps to catch the ball, but I try not to over do it... best of luck with your dog. Oh, in me, I broke out in hives... felt like it hurt to breathe for a while.. then slowly it went away. I thought I had an allergy. My dr tested me and I am positive for valley fever.
Submitted by may | June 3 2013 | Permalink
I just want to let everyone know there is an all natural formula called Desert Defense please google it. it saved my dog from valley fever. she was on the fluconazol for a few days then only the desert defense and the vet was amazing at how fast her numbers droped i also reccomended this to several friends whos dogs had VF and all of them where amazed at how great desert defense is. please look into it. you can usually get it from a feed store or pet specialty store or vet but dont need a perscription.
Submitted by Amanda | June 13 2014 | Permalink
I hope you get this message, since it is a year after you posted. My 11 month old Husky male has VF, (diseminated, I believe) he is on 200mg of Fluconazole and has very little appetite. His titre was 1:32, I started him on Desert Defense a few days ago. What was your dogs titre and how much fluconazole was he on before you discontinued it? Any helpful info you have would be much appreciated! Gotta save my boy.
Submitted by carlena | November 26 2013 | Permalink
Coccidioidomycosis (/kɒkˌsɪdiɔɪdoʊmaɪˈkoʊsɪs/, kok-sid-ee-oy-doh-my-KOH-sis), commonly known as cocci,[1] "valley fever",[2] as well as "California fever",[2] "desert rheumatism",[2] and "San Joaquin Valley fever",[2] is a fungal disease caused by Coccidioides immitis or Coccidioides posadasii.[3] It is endemic in certain parts of Arizona, California, Nevada, New Mexico, Texas, Utah and northern Mexico.[4] in the River Valley Areas it is Blastiomycosis....(sp?) It can be found anywhere in the US and bordering countries....
Submitted by Jeanie | July 31 2014 | Permalink
My dog, possibly a lab/weimaraner mix, is now on 315 mg capsules, up from 200, fluconasole twice a day. The vet's medicine was expensive but they told me about Roadrunner Pharmacy in Phoenix so I now pay $58 for 90 (45 days). He has had it, diagnosed in April 2013, and is now 2 1/2 years old. I recently had to change vets and the test was not as much, but they don't give me a years worth of medicine. He seems good, except that he sleeps a lot, but runs around the yard and then sleeps. I am looking for an alternative supplement. Anyone have any helpful knowledge for me? Thanks!
Submitted by Linda | August 21 2014 | Permalink
I don't know of a natural remedy. I going to ask my vet.
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NBC announced yesterday that they are developing a miniseries based on the life of "Tonight Show" host Johnny Carson.
They said the project will work of the upcoming biography called "Carson the Magnificent: An Intimate Portrait" from author and biographer Bill Zeheme. The book is said to encompass Johnny's childhood in Nebrasha, his private live behind the camera, and the friendships he made during his 30 years as host of "The Tonight Show".
What NBC didn't tell us...who will play the legendary late night host?
Casting for the role has yet to be announced and there is not a speciified airdate yet.
Johnny Carson passed away in January of 2005 at the age of 79.


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New images of the future Falcons stadium have just been released. More>>
Anybody worried about how Bruno Mars would do on one of the world's largest stages had obviously never seen the young star perform live. That all changed Sunday night when tens of millions got their first chance to see why he's one of the most exciting live acts of his generation. More>>
Check out pictures from Super Bowl XLVIII where the Seattle Seahawks took on the Denver Broncos for the NFL championship. More>>
If you want to see a good college football game, don't expect it to be cheap. Each of the top 10 most expensive tickets in college football costs more than $150. More>>
Check out these photos of Atlanta Braves fans showing off their team spirit. More>>
Check out these photos from The Masters in Augusta, GA. More>>
The teams from Syracuse, Michigan, Louisville and Wichita State practiced at the Georgia Dome on Friday to get ready for the Final Four. More>>
Bill Halstead, the father of Tripp Halstead, got the chance to meet his favorite team on Wednesday as they practiced in Atlanta for the Final Four - the Syracuse University men's basketball team. More>>
While the crowd, his teammates and coaches looked on in horror, Louisville guard Kevin Ware, a metro Atlanta native, suffered a serious leg injury during the Duke-Louisiana game on Sunday. More>>
The Braves will open their season against the Philadelphia Phillies at home Monday at 7:10 p.m. More>>
As the nation gets ready to crown an NFL champ, some fans continue to wait - some for generations - for their favorite team to bring home its first Lombardi trophy. More>>
The Braves Country Caravan provides the opportunity to engage fans with players, coaches and broadcasters to create lasting memories in each of its stops. More>>
Falcons fans rise up! Check out these BIGGEST fans in the Atlanta area.
A Luthersville man considers himself one of the biggest Atlanta Falcons fans in metro Atlanta and he has a decked out man cave to prove it. More>>
The Alabama Crimson Tide and the Notre Dame Fighting Irish meet Monday to determine the winner of the 2012 season BCS National Championship. More>>
Check out these images from the Georgia Dome where the SEC Championship is being played. More>>
Dawgs fans and Gator fans alike came out to tailgate before the Georgia-Florida game in Jacksonville on Oct. 27. More>>
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Women's New Balance 792 Casual Walking Shoes
Add some comfort to your regular walking routine with the New Balance 792 Casual Walking Shoes. Perfect for your everyday workout, these sneakers are designed to offer durability and support as you enjoy the great outdoors.
Ditch the weight of traditional bulky walking and running shoes with these innovative sneakers from New Balance. Designed with a revolutionary REVlite midsole that offers responsiveness and shock absorption, these shoes feature a 30% reduction in weight over sneakers that use other midsole materials. A solid rubber outsole keeps these shoes in shape mile after mile, while the synthetic and mesh upper ensures the support you need without any added weight.
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Curved V-Shape Crystal Necklace and Earring Set Style TL-0434
Final sale. This item cannot be exchanged or returned.
This item is available in stores and online.*
Curved V-shape crystal necklace and earring set is sophisticated and refined.
Sheer netting or veiling that extends the length of a cathedral gown.
customers bought with this dress
*Color & Style representation may vary by monitor. Not responsible for typographical or pictorial errors. Product availability varies by store and online. Some in-store purchases require special order and markdown styles cannot be special ordered. Contact your local store for details.


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MODERN FAMILY - "Under Pressure" - The high school open house puts the parents in a bit of a time warp when Claire finds herself stressed out by all the pressure, Gloria encounters a "mean girl" mom (guest star Jane Krakowski) and Jay teaches Phil how to play a little hookie. Elsewhere, Mitchell gets defensive when he encounters his judgemental, environmentalist neighbor (guest star Jesse Eisenberg) and Alex goes to see a therapist (guest star John Benjamin Hickey), on "Modern Family," WEDNESDAY, JANUARY 15 (9:00-9:31 p.m., ET), on the ABC Television Network. (ABC/Richard Cartwright) RICO RODRIGUEZ, CHELSEA SUMMER, BROOKE STAR, NOLAN GOULD
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{mosimage}The computer is a pretty big power drain. But it could be a lot worse. Right now, mine cranks on the juice required to power two lightbulbs, and I consider that to be pretty effiecient. But it could be better.
Computer power drain is becomming a bigger deal, especially as prices continue (and will continue) to rise. At least utntil we get that cold fusion thing worked out. Those of vignovin.com us who are concerned about that kind of thing should definitely check out Power Consumption and the Modern Geek, a report from the the best place viagra free pills folks at Extreme Tech. They've done a pretty comprehensive survey of the most significant power drains geeks are most likely to levitra online pharmacy face, and what can be done to limit these juice-hungry boxes without limiting heir power.
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Comments (4)
written by Kurosaki Ichigo, April 01, 2007
true, true. We really should start getting better and more efficient computers.
power supply )
written by diamond rings, January 11, 2008
good idea
efficient computer
written by Tim, August 06, 2009
I took power consumption into account during my last computer build. I was able to come out of it with a computer that uses Nvidia's hybrid SLI. In normal energy saving mode, the computer uses 58W. When I want to do any 3d work/gaming, I enable performance mode and it kicks my power consumption to around 100W+. You pay a lot for fancy graphics! Also note, this is only the power consumption of the computer itself, it does not include monitor, speakers, router, etc.
written by vanzare apartamente, February 12, 2010
It will be a challenge to save energy because the bigets consumer are the processors
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802.11b/g/n In-wall Wireless Access Point. PoE-enabled.
Now with dual jacks for both data and phone.
The EW28650 802.11b/g/n wireless access point is designed to fit into a standard single gang box. Finally a solution to fixing WiFi range problems.
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Publisher Information
|University of Bergen
|Browse books by this publisher.
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Presents a new theoretical framework for the origins of human language and sets key issues in language evolution in their wider context within biological and cultural evolution
This is the first study that empirically investigates preposition placement across all clause types. The study compares first-language (British English) and second-language (Kenyan English) data and will therefore appeal to readers interested in world Englishes. Over 100 authentic corpus examples are discussed in the text, which will appeal to those who want to see 'real data'
Free access to several Brill linguistics journals, such as Journal of Jewish Languages, Language Dynamics and Change, and Brill's Annual of Afroasiatic Languages and Linguistics.
|University of Bergen
|Browse books by this publisher.
|Main URL


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POWER BALANCE Game Day Silicone Wristband
|Eligible for Free Shipping on Orders $49 or More! (see promotion details)
|Members of The League get 5% back when you spend $100! (see promotion details)
Product Details
Whether you're on your home turf or traveling, you can still show your favorite team some love with this POWER BALANCE® Game Day wristband! This 100% non-toxic silicone wristband is reversible, with both sides featuring your squad's colors. Holograms on each side complete the band's eye-catching look.
Get your new POWER BALANCE® wristband today from Sports Authority.
- 100% non-toxic silicone wristband
- Reversible design
- Opposite-colored holograms
- Made in China
Product Recommendations
Product Reviews
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Comments about POWER BALANCE INC POWER BALANCE Game Day Silicone Wristband:
Just for the fun of wearing it
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Dongbang Incense Sticks - Classically Scented (DB210B)
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It's ironic to me that a network that has morphed into so much that is wrong, can get something so incredibly right. I'm talking about ESPN and their Saturday morning must-see: College Gameday.
ESPN shot to the top by recognizing the changing landscape of sports reporting and delivering (better than anyone…and before anyone) on the promise to balance information with entertainment. Along the way, the network decided to advance itself as the conscience of the information they supply – that's a problem. Couple that with lucrative broadcast contracts that have influenced how and on what they report, and now you've got a real mess.
Regardless, I am not one of those "Four Letter Network" bashers that fails to recognize the complexity of today's broadcast media and the pressures to remain on-top.
With more credible suitors than ever for the same slice of ratings real estate, it is more difficult than ever to achieve a responsible balance. Too often, that difficulty results in a guy in a suit overthinking something and messing with a product that needs no tinkering. That's precisely why I cannot believe College Gameday has been permitted to proceed as is for so long. I'm ecstatic, for it is fantastic – a true weekly must-see.
Check out how they handled this dude this past weekend. This is what I mean – they get it. Information: check. Entertainment: check. Willingness to embrace the lunacy of your environment: check. College Gameday is the perfect execution of the sports broadcasting formula for success.


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The new video from Neon Trees is awesome! It's like a trip to the 1980's :)
A Pearl Jam fan had his nose broken by PJ's bass man Jeff Ament last week. It was not some on stage scuffle, or even a back stage rock and roll incident though.. It was actually a what the fan describes as a rough game of basketball. Well that's.. Still.. Kind of exciting. Right?
Sherif Hassan tells Australia's Triple J that Ament actually broke his nose during the pick-up game in New Zealand, which also included Arcade Fire frontman Win Butler. Hassan says Ament made up for the broken nose by giving him and some friends tickets to the event and backstage passes. He says the injury didn't bother him as much after he spent some time hanging out with New Zealand singer Lorde between shows and got a shout out from Eddie Vedder during Pearl Jam's performance.
Kids down unda are tough!
We love the new song "I Believe" by Basic Vacation. We love it so much that we want to give you a free download!
Love, X96.
As the resident punk/ska nerd, not to mention the 90's at Noon guy.. It's officially my job to let the kids know when a ska show rolls through town. Reel Big Fish will be stopping in SLC tomorrow night on their "Don't Stop Skankin'!" tour. It will be nice to see them do a full set since they were only allowed the standard 30 minutes when they were here for Warped in the summer.
Also, I'm stoked to see my friends from Suburban Legends open up the show! If you've been to Disneyland in the last few years, you might have caught SL in Tomorrowland. They're one of the bands that gets to rise up on the Tomorrowland Terrace stage and rock the kids with punk versions of Disney songs, and mad choreography :) All of which we'll see tomorrow night at The Murray Theater. Oh! and our local pals The Anchorage will be there! We saw them at the X96 Nightmare Before Xmas last month!
I can't wait to skank with the kids! And by "skank" I mean "Stand in the back and eat nachos"
See you there!
Tyler Glenn for Neon Trees talks about the brand new song, the new album, and why he was almost ready to quit!
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6 Super-Cute St. Patrick's Day Crafts
We know you don't need an excuse to break out the rainbow glitter, but these creative craft ideas will definitely make you reach for your scissors and glue.
By Christine Kopaczewski
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Hang a Banner
Your mantel deserves some decor year-round (not just at Christmas). This bright green banner rings in St. Paddy's Day — and welcomes spring.


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Don't fret! Check out these suggested similar and related items below. Happy shopping!
BHI/Heel Bleeding 100 Tablets
BHI/Heel Bleeding is a homeopathic medication for the temporary relief of nosebleeds, excessive mentruation, and minor injuries. Bleeding is a safe, effective, natural remedy ideal for all ages, including children and seniors. The inclusion of multiple active ingredients represents the modern approach to homeopathic treatment employed worldwide by Heel. The all-natural ingredients in Bleeding help to relieve:
The human body is one of nature's works of art. When it is healthy, it is perfectly in tune with itself and the environment. But sometimes that balance is disturbed and people become ill. That is where BHI/Heel comes in. Their medications gently promote the body's processes of self-healing, helping it combat illness and recover its biological balance.
Homeopathic combination medications are made of several different natural substances are easy to use fulfill high quality standards. But what exactly are homeopathic combination medications? In classical homeopathy, a single medication is prescribed based on the patient's physical and mental symptoms. BHI/Heel approaches homeopathy in a new way.
These combination medications are made up of several different natural substances, mostly homeopathically prepared. These have been carefully chosen and blended to stimulate various biological functions. They are then used, just like conventional medications are, to treat one particular condition like the common cold or dizziness.
Active ingredients: Thlaspi bursa pastoris 4X, Aceticum acidum 6X, Crocus sativus 6X, Ipecacuanha 6X, Arnica montana, radix 8X, Erigeron canadensis 8X, Hamamelis virginiana 8X, Millefolium 8X, Bovista 12X, Phosphorus 12X, Crotalus horridus 15X.
Inactive ingredients: Lactose, Magnesium stearate.
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Colorblock Layer Peplum Top
Style # 212758
AVAILABILITY: Unavailable for immediate shipment.
Give your new-season style a bold color pop with this flirty little bebe peplum top, featuring a waist-cinching flare and a layered hemline exposing a hint of pink. Try it with a black pencil skirt and a pair of studded sandals.
- 60% rayon, 35% nylon, 5% spandex
- Center back to hem: 23" (58 cm)
- Imported


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The Weekday diet.
A study suggests... People should focus on eating healthier during the week because we gain the most weight on the weekends.
Researchers studied several people and found they weighed more on Sundays and Mondays, with their weight steadily decreasing during the weekdays reaching the lowest point on Friday.
CONCLUSION: This shows we gain most of the weight on the weekends, and to offset that, people should focus on eating healthy lunches and dinners during the week.
Get the full story at dailymail.co.uk


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Interchange News
Perl::Dancer Conference 2014
Posted on 22-Aug-2014 by Jon Jensen
Building on the success of last year's Ecommerce Innovations conference, another conference is being held this year from October 6-9 at West Branch Resort in Hancock, New York. The focus has been broa...
Read more...
Interchange 5.8.2 stable release
Posted on 07-Jul-2014 by David Christensen
We're pleased to announce the immediate release of Interchange 5.8.2, the latest stable version of Interchange. It includes all known bug and security fixes, as well as feature enhancements including ...
Read more...
About Interchange
- Roadmap
- Online demo
- Hall of Fame (sites running Interchange)
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- Interchange history
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- Endorsements
- Contact
What Interchange users are saying:
"We have used Interchange since 1997 to run a very high traffic e-commerce site. Over the years interchange has become extremely stable and very fast. I would never consider using anything else. "
Tony Beaumont, DRS Inc.
Tony Beaumont, DRS Inc.
Users & Developers
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- Issues, tracked on GitHub


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Slide 1
Proper biospecimen handling is the first essential element in the drive toward personalized medicine for cancer. The molecular changes trapped in cancer biospecimens provide insightful clues about what went wrong in a patient's cells. It is critically important to understand how to collect cancer biospecimens properly, so that the information obtained from analyses, using approaches such as genome-wide profiling, are correct and not artifacts of mishandling.
Slide 2
Get Patient Consent
Health professionals explain to the patient that their tissue donation is very important to accelerating progress in cancer research. When permission is given, the consent form is archived carefully and uniquely linked to the sample.
Slide 3
Procure and Stabilize Sample
A biospecimen is removed from the patient, taking great care to keep the sample biologically viable.
Slide 4
Attach Unique Identifier
A unique identifier is associated with the biospecimen. Unique identifiers link the tissue sample with its relevant annotated records, so future results from studies using this sample can again be associated with the original patient donor.
Slide 5
Store Carefully
A biospecimen is carefully stored in a location that monitors temperature and conditions to properly support the integrity of the tissue.
Slide 6
Retrieve and Re-store Carefully
When needed for analysis, a biospecimen is carefully retrieved, and if any sample remains afterward, it is re-stored with care.
Slide 7
Best Practices
By properly labeling the tissue sample, fully recording discoveries associated with the tissue, and following the National Cancer Institute's best practices guidelines for handling the material, health professionals can ensure that a cancer biospecimen is of the highest quality when it is used for genome-wide profiling or other research studies.
For more details on the best practices in biospecimen collection please see: http://biospecimens.cancer.gov