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Adjuvant Chemotherapy Improves Survival in Advanced Endometrial Cancer
Results from a phase III clinical trial initially presented more than 2 years ago have been published and, according to several experts, represent a new standard of care for treating women with advanced endometrial cancer. In the trial, adjuvant chemotherapy improved overall and disease-free survival compared with whole abdominal irradiation (WAI) in women with advanced disease. The results were released early online by the Journal of Clinical Oncology (JCO) on December 5.
Looking Back on a Year of Success and Hope
As I revisit all that has happened over the past year in cancer research, I reach an inescapable conclusion: We are not only expanding our foundation of knowledge and tools with which rapid advances can be made in understanding the mechanisms of cancer, we are also exponentially increasing the opportunities to manage this lethal disease.
The Clinical Proteomics Technologies Initiative launched this year, for instance, will improve the technologies used in proteomics research - a field that is offering new avenues for early detection and diagnosis. There also is The Cancer Genome Atlas Pilot Project, which will yield information about genetic determinants of susceptibility to cancer while laying the groundwork for a full-scale understanding of the genetic etiology of cancer. And the establishment of the NCI Alliance for Nanotechnology in Cancer, including Centers of Excellence and new training programs, will explore new worlds of diagnosis and treatment.
Technology will undoubtedly accelerate progress, but it is just one piece of our robust National Cancer Program. Read more
Adjuvant Chemotherapy Improves Survival in Advanced Endometrial Cancer
Results from a phase III clinical trial initially presented more than 2 years ago have been published and, according to several experts, represent a new standard of care for treating women with advanced endometrial cancer. In the trial, adjuvant chemotherapy improved overall and disease-free survival compared with whole abdominal irradiation (WAI) in women with advanced disease. The results were released early online by the Journal of Clinical Oncology (JCO) on December 5.
Led by the Gynecologic Oncology Group (GOG), the NCI-funded trial, GOG 122, is the first to show a survival benefit for adjuvant chemotherapy in this patient group. In a commentary in JCO, Dr. Gini F. Fleming of the University of Chicago called the results "a milestone in the treatment of endometrial cancer."
According to the trial's lead investigator, Dr. Marcus Randall of the Brody School of Medicine at East Carolina University, the results should make WAI a relic of the past for most women with advanced disease. "Based on the results of this study, WAI should have no role or close to no role in managing these patients," he said.
The 422 women in the trial had stage III or IV endometrial carcinoma with a maximum of 2 cm of postoperative residual disease: 202 received WAI after surgery and 194 received 7 cycles of doxorubicin and cisplatin, plus a single cisplatin cycle. At 60 months, 55 percent of patients in the chemotherapy arm were alive, compared with 42 percent of patients in the WAI arm; disease-free survival was 50 percent vs. 38 percent, respectively.
The chemotherapy regimen in GOG 122, which began accruing patients in 1992, has fallen out of favor for treating many solid tumors because of toxicity. Not surprisingly, patients in the chemotherapy arm were far more likely to have high-grade hematologic toxicities such as low white blood cell levels and gastrointestinal effects. Only 63 percent of patients completed the full chemotherapy regimen, compared with 84 percent of those treated with WAI.
Surgery is the first-line treatment for endometrial cancer. Because most patients present with stage I disease, hysterectomy can often be curative, according to Dr. Edward Trimble of NCI's Division of Cancer Treatment and Diagnosis (DCTD).
Surgery also helps clinicians stage the disease and make more informed decisions about next treatment steps. Stage I disease, for example, means the tumor is confined to the uterus. Stage III disease indicates the disease has spread, often to the lymph nodes.
According to Dr. Randall, community oncologists are already using adjuvant chemotherapy to treat advanced disease, a trend that began after the initial release of the trial's results at the American Society of Clinical Oncology annual meeting in 2003.
Clearly, though, the toxicity seen with the doxorubicin/cisplatin regimen has affected how adjuvant chemotherapy is being employed.
While there are no data from randomized trials in endometrial cancer to necessarily support it, Dr. Trimble said, "A lot of oncologists are using carboplatin and paclitaxel, which is better tolerated."
GOG is conducting a phase III trial comparing carboplatin and paclitaxel with doxorubicin, cisplatin, and paclitaxel for advanced disease.
The GOG 122 trial is by no means the death knell for radiation, Dr. Trimble continued, particlarly radiation therapy that is more focused on known tumors. "There is room to study radiation because we know it helps with local control," he said. "We think the new paradigm may be a tri-modality therapy, with surgery plus chemotherapy and radiation."
By Carmen Phillips
Looking Back on a Year of Success and Hope
As I revisit all that has happened over the past year in cancer research, I reach an inescapable conclusion: We are not only expanding our foundation of knowledge and tools with which rapid advances can be made in understanding the mechanisms of cancer, we are also exponentially increasing the opportunities to manage this lethal disease.
The Clinical Proteomics Technologies Initiative launched this year, for instance, will improve the technologies used in proteomics research - a field that is offering new avenues for early detection and diagnosis. There also is The Cancer Genome Atlas Pilot Project, which will yield information about genetic determinants of susceptibility to cancer while laying the groundwork for a full-scale understanding of the genetic etiology of cancer. And the establishment of the NCI Alliance for Nanotechnology in Cancer, including Centers of Excellence and new training programs, will explore new worlds of diagnosis and treatment.
Technology will undoubtedly accelerate progress, but it is just one piece of our robust National Cancer Program.
Within the other parts of our portfolio, an important project completed this year was the work of the Clinical Trials Working Group, which produced 22 recommendations for reworking the NCI clinical trials program to make it more effective and efficient. In May, NCI also made an unprecedented commitment to addressing disparities in cancer care with the launch of the Community Networks Program (CNP). The $95 million CNP will help to implement community-based projects aimed at reducing disparities in underserved populations.
Large-scale clinical trials in 2005 yielded results that will have profound effects in preventing and treating many cancers. For example, three different clinical trials showed that adding trastuzumab to chemotherapy significantly reduced the risk of recurrence in women with early-stage, HER-2 positive breast cancer. Results from the Lung Health Study showed that intensive smoking-cessation programs not only can help people stop smoking, but, for those who do quit, can significantly improve long-term survival. Stunning results were seen in an HPV vaccine trial, demonstrating that most cases of cervical cancer can be prevented, which will have important implications in underdeveloped countries. And in September, results from the DMIST trial demonstrated that a subset of women can significantly benefit from digital mammography.
In the laboratory, there were numerous studies that yielded noteworthy results, often using ingenious techniques or novel approaches. Researchers from NCI and the University of Minnesota, for example, published a study demonstrating how employing "jumping DNA" called transposons in mouse models may enable us to identify new cancer genes. In addition, researchers from the University of Michigan studying prostate cancer identified for the first time, the presence of a commonly fused gene in a solid tumor. The researchers believe other solid tumors may also harbor common translocations, which could serve as biomarkers of disease.
These are just samples of the outstanding work being done every day by cancer researchers. Eliminating the suffering and death due to cancer by 2015 is a bold and ambitious goal, but this past year has demonstrated progress that gives us hope.
Certainly there are significant hurdles to overcome, from tough budgetary decisions to the physical limitations of available research tools. But our progress is consistently accelerating and there is ample proof of the principle that the mechanisms of cancer are vulnerable. In 2006, as cancer yields to our determined attack, lives will be saved.
Dr. Andrew C. von Eschenbach
Diabetes and Pancreatic Cancer: Testing the Insulin Hypothesis
As the incidence of diabetes rises around the world, researchers are starting to recognize the possibility that in the coming decades cancers associated with diabetes may become more common as well, particularly in the United States as the population ages.
Cancers of the colon, breast, liver, and pancreas are among those that tend to occur with type 2 diabetes among adults. But the epidemiological studies on the subject are inconsistent, and researchers are only beginning to understand how the diseases might be related and how best to treat patients with both.
"We know what happens to patients with cancer, and we know what happens to patients with diabetes, but we know little about how the two diseases interact in patients who have both," says Dr. Lisa Richardson, a medical oncologist in the Division of Cancer Prevention and Control at the Centers for Disease Control and Prevention.
Surprisingly few studies have been done specifically to understand how the diseases are related, notes Dr. Richardson. Instead, researchers have focused largely on identifying cancers that occur with diabetes (or prediabetic states) and explaining why this happens.
A theory about pancreatic cancer and diabetes, to take one example, says that during the early stages of diabetes the pancreas produces extra insulin, and this insulin may spur the growth of cells, leading to tumors.
The insulin hypothesis is supported by experiments in human cells and in animals. Now more support comes from a study involving 29,000 male smokers in Finland that appears in tomorrow's Journal of the American Medical Association (JAMA).
In the study, men with the highest insulin levels were twice as likely to develop pancreatic cancer as men with the lowest levels, says lead researcher Dr. Rachael Stolzenberg-Solomon of NCI's Division of Cancer Epidemiology and Genetics.
Similarly, men with glucose levels in the range of clinical diabetes were twice as likely to develop the cancer as men with normal levels.
When the men joined the study in the mid-1980s, they had their blood drawn after fasting overnight. This allowed the researchers to know insulin and glucose levels many years before the cancers appeared; over the course of 17 years, 169 men developed the cancer.
"This is a very well done study, and it supports the long-standing hypothesis that insulin is a growth promoter for pancreatic cancer," says Dr. Charles Fuchs of Harvard Medical School, an expert on pancreatic cancer who was not involved in the study.
In their analysis, the researchers excluded men who developed the cancer within 5 years of having their blood drawn. This reduced the likelihood of including men whose elevated insulin levels were caused by undetected pancreatic tumors, as can happen.
Smoking, aging, and perhaps obesity are the only known risk factors for pancreatic cancer, one of the most deadly cancers. There are few treatments, and the cancer is frequently discovered only after a tumor has spread.
"This study of insulin levels gives us another important clue about the various influences that are probably important in the risk of developing pancreatic cancer, particularly in smokers," says Dr. Demetrius Albanes, the senior researcher of the NCI team.
The findings need to be replicated in other groups, including women and nonsmokers, but the results are consistent with other recent studies.
Last January, for instance, a study in JAMA found that diabetes and elevated fasting glucose levels were independent risk factors for several major cancers, including pancreatic cancer, among 1.3 million Koreans.
The participants were "far leaner" than those found in studies involving Westerners. Noting that obesity was not a factor in the results, the researchers suggested that elevated insulin levels may account for the increased cancer risk.
In May, an analysis of 36 studies involving diabetes and pancreatic cancer found a "modest causal association" between type 2 diabetes and the cancer. After obesity and smoking, diabetes may be the third modifiable risk factor for pancreatic cancer, the researchers concluded in the British Journal of Cancer.
"Unless the increasing worldwide prevalence of all three risk factors is halted, the incidence of pancreatic cancer will rise substantially within the next couple of decades," warned Dr. Rachel Huxley of the University of Sydney and her colleagues.
By Edward R. Winstead
Two Breast Cancer Treatments Show Benefit
Results from an NCI-funded, phase III clinical trial comparing the effectiveness of the drugs paclitaxel and docetaxel, delivered over two different dosing schedules, showed that - regardless of the dosing schedule - both drugs provided similar benefits for women with stage II or III operable breast cancer. Study results were presented at the San Antonio Breast Cancer Symposium on December 8.
Both paclitaxel and docetaxel are approved for the treatment of breast cancer that has spread to lymph nodes. Although these drugs have been shown to be beneficial in treating breast cancer, this is the first time they have been directly compared in a weekly versus 3-week dosing schedule to treat early-stage breast cancer.
"Although both drugs are used as adjuvant breast cancer treatments, which drug and which schedule are most effective has been a question for many years," said Dr. JoAnne Zujewski, who oversees breast cancer trials for NCI's Cancer Therapy Evaluation Program. "Now doctors and patients will be able to consider side effects, convenience, and cost in determining treatment without concern that effectiveness will be compromised."
A total of 4,988 women were enrolled in the trial between 1999 and 2002 and were followed for a median of about 4 years. All of the women had axillary lymph node-positive or high-risk node-negative breast cancer. All women were first treated with a standard treatment protocol and were then randomly assigned to groups that received either paclitaxel or docetaxel, administered weekly for 12 weeks or every third week over a 12-week period.
Adjuvant Chemo for Stage III Colon Cancer Increasing,
The use of adjuvant chemotherapy in patients with late-stage colon cancer has increased significantly since recommendations from a 1990 NIH consensus conference advised clinicians to implement the practice, a new study has found. But, the study authors report, nearly one-third of patients with stage III colon cancer still receive surgery only for treatment, particularly female and elderly patients.
In the study, Dr. John Jessup, from Georgetown University Medical Center and temporarily on assignment with NCI's DCTD, and colleagues reviewed prospective data from the National Cancer Data Base on nearly 86,000 patients treated for stage III colon cancer between 1990 and 2002. Overall, they reported in the December 7 Journal of the American Medical Association, the use of adjuvant chemotherapy increased from 39 percent in 1991 to 64 percent in 2002. When compared with surgery alone, this increase was associated with a 16-percent improvement in 5-year survival.
The 1990 recommendations were based on two large, randomized clinical trials that demonstrated significant improvements in disease recurrence and overall survival with a 12-month postsurgery chemotherapy regimen. After the recommendations' release, adjuvant chemotherapy use increased and then stabilized by the mid- to late-1990s. A second increase followed results in clinical trials that demonstrated an adjuvant regimen of 6 months of 5-fluorouracil (5-FU) and leucovorin was as effective and less toxic as the standard regimen of 12 months of 5-FU and levamisole.
With recent studies using newer agents showing increased efficacy and less toxicity than 5-FU/leucovorin, noted Drs. Eric Van Cutsem and Frederico Costa in an accompanying commentary, use of adjuvant chemotherapy should continue to expand. "Shorter and more effective therapies are easier to incorporate in daily practice," they wrote, "and might overcome…reluctance of the patient or the physician to be treated with adjuvant chemotherapy."
Breast Cancer Cluster Not Linked to Environment
Long Island has been the focus of intensive investigation to uncover reasons for the high rates of breast cancer in its Nassau and Suffolk Counties. NCI and the National Institute of Environmental Health Sciences (NIEHS) have supported research to evaluate whether environmental exposures may be responsible through the series of studies in the Long Island Breast Cancer Study Project (LIBCSP). In the December issue of Nature Reviews Cancer, Dr. Deborah Winn, of NCI's Division of Cancer Control and Population Sciences, reviewed the results of LIBCSP, as well as studies of other regions with high breast cancer rates.
In case-control studies, researchers focused on participants' exposure to organochlorines (a class of chemicals that includes pesticides and other industrial chemicals), polycyclic aromatic hydrocarbons (a pollutant caused by incomplete combustion of various chemicals including diesel fuel and cigarette smoke), and electromagnetic fields in and near participants' residences as possible causes. In general, the researchers found no significant association between the regional environment and high breast cancer incidence.
Similar results were seen in a study of women in affluent Marin County, California, where breast cancer incidence also is high. What that study did show was that heavy alcohol consumption was linked with the disease. Higher regional breast cancer rates may also be due to reproductive patterns that are correlated with affluence, including late age at first birth and fewer children.
"In the view of some, findings of no environmental association indicate failure of the research," notes Dr. Winn. "However, findings of no association that are obtained through rigorous research are important. If the evidence shows that there are no credible associations between the suspected risk factors and the disease, then research can be directed toward other potential carcinogens." She points to improved understanding of gene-environment interactions and measurement of environmental exposures as important contributions from the LIBCSP.
NIEHS and NCI are currently exploring these issues further by supporting the Breast Cancer and the Environment Research Centers (www.bcerc.org).
Application Receipt Dates: April 1, Aug. 1, and Dec. 1, 2006; April 1 and Aug. 1, 2007.
This is a renewal of PA-04-156. This funding opportunity will use the R43 and R44 award mechanisms. For more information see http://cri.nci.nih.gov/4abst.cfm?initiativeparfa_id=3296. Inquiries: Dr. Sharon Ross - firstname.lastname@example.com; Connie Dresser - firstname.lastname@example.com; Dr. Audie A. Atienza - email@example.com.
Bioengineering Approaches to Energy Balance and Obesity (STTR [R41/R42])
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Research on Social Work Practice and Concepts in Health (R01)
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Research on Social Work Practice and Concepts in Health (R03)
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Research on Social Work Practice and Concepts in Health (R21)
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Mentored Quantitative Research Development Award (K25)
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Treatment for Castleman Disease
Name of the Trial
Principal Investigator
Why Is This Trial Important?
In this trial, symptomatic patients will be treated with high-dose zidovudine (HDAZT) and valganciclovir. These antiviral drugs are converted into toxic compounds by KSHV-encoded proteins. These toxic compounds may lead to specific killing of KSHV-infected cells (MCD tumor cells). Patients who do not respond to this treatment will also receive the drug bortezomib to see if it can increase the ability of KSHV to activate HDAZT and valganciclovir and increase tumor cell death.
Patients with no symptoms will be monitored without therapy for MCD. HIV-infected patients will receive treatment for HIV, called highly active antiretroviral therapy or HAART, if appropriate. Patients who develop life-threatening disease will be treated with conventional chemotherapy (EPOCH-R) to try to bring their disease and symptoms into remission.
"Laboratory research indicates that certain KSHV genes can activate HDAZT and valganciclovir to kill tumor cells," said Dr. Little. "If this approach works in patients with MCD, it may provide the basis for exploring similar strategies for other viral-associated tumors."
Who Can Join This Trial?
Where Is This Trial Taking Place?
Contact Information
An archive of "Featured Clinical Trial" columns is available at http://cancer.gov/clinicaltrials/ft-all-featured-trials.
The 5th International Conference of the African Organization for Research and Training in Cancer (AORTIC), "Cancer in Africa: A Call to Action," took place in Dakar, Senegal, on November 14-17.
The conference was attended by 406 people from 37 countries. Senegal President Abdoulaye Wade opened the meeting with a pledge of personal support for the development of cancer programs in Africa. The keynote addresses were delivered by Dr. Simon Schraub of the Centre Paul Strauss in Strasbourg, France, and Dr. Joe Harford of NCI. For more information about AORTIC, go to www.aortic.org.
Roberts and Sporn Win Komen Brinker Award
Drs. Roberts and Sporn have collaborated for more than 30 years on research on transforming growth factor beta, a messenger molecule integral to the activities of the cell cycle. Their work is now forming the basis of new therapeutic approaches in breast cancer.
The award was established by the Susan G. Komen Breast Cancer Foundation in 1992 to recognize extraordinary achievement in breast cancer-related basic and clinical scientific research. Dr. Trevor J. Powles of Parkside Hospital in London received the award for clinical research.
Seminar Describes Cancer Disparities
Several media outlets reported stories based on the event. HealthDay News published a story about the fatalism of some cancer patients, including those affected by poverty and lack of education, which also appeared on Forbes.com. The largest weekly newspaper serving Native Americans, Indian Country Today, is planning an article about cancer in the Native American community that will highlight NCI's Community Networks and Patient Navigator programs. A number of radio interviews with NCI staff also resulted from the seminar.
Software for Proteomics Analysis Available
The new software platform is the first comprehensive, freely available resource for proteomics researchers. A paper describing the base system was published early online December 8 in the Journal of Proteome Research.
The software version 1.1, an analytical platform supported by NCI's cancer Biomedical Informatics Grid™, was developed at the Seattle-based Hutchinson Center as part of a large NCI-funded research consortium to develop basic platforms for research into proteomics. Members of the Hutchinson Center-led consortium include the Institute for Systems Biology, Pacific Northwest National Laboratory, and the Plasma Proteome Institute.
CPAS will provide researchers with open-source tools for organizing, managing, processing, and interpreting the vast amounts of data generated by proteomics and other biological experiments.
For more information, go to https://cabig.nci.nih.gov/workspaces/ICR/CPAS/document_view.
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The Cancer Genome Atlas Begins with 3-Year, $100 Million Pilot
Leaders from NCI and the National Human Genome Research Institute (NHGRI) today launched the Cancer Genome Atlas (TCGA) Pilot Project, a comprehensive effort to accelerate understanding of the molecular basis of cancer.
The TCGA Pilot Project will be monitored using specific milestones for certain components of the project and the overall project will be evaluated on the basis of key success factors. A pilot project is required to establish processes and determine feasibility; a decision to scale up TCGA at the completion of this 3-year period will be based on achieving these success factors. At a news conference in Washington, D.C., NCI and NHGRI each pledged $50 million over 3 years to the pilot.
NCI Deputy Director Dr. Anna Barker said, "TCGA is a revolutionary program which capitalizes on so much of what we've accomplished in the last 30-plus years of biomedical and cancer research. The Human Genome Project produced an amazing product, and we are now positioned to leverage the human genome sequence for TCGA. This is the first attempt to use large-scale gene sequencing for human health - and I am glad that cancer patients and their families will be the beneficiaries. The project will enable a new generation of discovery and empower translational and clinical research across all sectors. Our intent is that all of the data move quickly into the public domain for everyone's use."
Cancer includes more than 200 different diseases, each with a set of genetic changes that results in uncontrolled cell growth. The TCGA Pilot Project will develop and test the science and technology needed to systematically identify the genetic changes in a small number of cancers.
Such an exploration of the genetic origins of the many diseases called cancer would not have been possible a decade ago. But new technologies and genome analysis tools, especially large-scale genome sequencing, have led scientists to a better understanding of how and why genetic changes cause cancer.
Many of these insights and technologies evolved during the Human Genome Project (HGP), an international effort led in the United States by NHGRI and the Department of Energy, and completed in April 2003, which provided a reference DNA sequence of the human genome. Just as HGP enhanced the availability of genomic tools, TCGA is expected to lead to new technologies for high-throughput, cost-effective analysis of the cancer genomes.
The TCGA Pilot Project will consist of: a Core Human Biospecimen Resource to collect, quality-assure, and distribute biomolecules from the samples; Genome Characterization Centers that will employ genome analysis technologies to identify key genomic and epigenomic changes; Genome Sequencing Centers to resequence candidate genes identified through data integration from all program components; a Bioinformatics Core Resource which will develop the bioinformatics and analysis tools needed to integrate and deploy TCGA's database through NCI's cancer Biomedical Informatics Grid™ and NIH's Center for Bioinformatics; and a Technology Development Program that will focus on driving new genome analysis technologies through individual investigator grants and NCI's SBIR program. For more information, go to http://cancergenome.nih.gov.


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Numi's vision is to inspire well-being of mind, body and spirit through the simple art of tea. Numi elevates the tea experience through quality, creativity, and authenticity. We are grateful to those who contribute to our tea journey, and we hope to have a positive impact on all members of our community - from farmer to packer to our fellow tea drinker. Conscientious of the impact of our actions, we aspire to be environmentally responsible and globally sustainable by using recyclable and biodegradable packaging and sustainable bamboo in our merchandising.
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Numi Organic - Herbal Tea Moroccan Mint - 18 Non-GMO Biodegradable Tea Bags (1.40 oz. / 39.6 g)
Numi Organic Moroccan Mint Herbal Tea (formerly Numi Moroccan Mint, Organic Simply Mint) contains refreshing sweet mint leaves. Numi's organic Moroccan Mint, known as "nana mint," flourishes in North Africa. With a flavor as light and lively as a newly picked leaf, it has a sweet spearmint taste that is refreshing and soothing any time of day.
Herbal TeasansTea is a misnomer for anything steeped in hot water. Teas come from the tea plant. "Teasans" is Numi's term, from the French tisanes, for brewed herbal beverages brewed from herbs, fruits or flowers. Strictly speaking, Teasans contain no tea leaves. They have a variety of flavors from minty, to sweet chamomile to tart lemon. They contain no caffeine and have an abundant and varied health benefits depending on the herb, flower or fruit.
Numi Organic Tea - The Purest Tea on the Planet
Why OrganicAs with all intensively farmed crops, conventional tea is routinely treated with a broad range of agricultural chemicals that are potentially harmful to farmers, farm workers and the environment. As opposed to most produce that is washed prior to consumption, most teas are air-dried without first being washed. The first time tea comes into contact with water is in our own cups, right before we drink it. This means that any harmful chemicals used at the gardens are released in our cups along with the tea flavor.
At Numi, they are committed to supporting organic tea cultivation to protect the health of farmers, the planet and you. Beyond delivering the highest quality of product, organic teas are cultivated without the use of chemical fertilizers, herbicides or pesticides. Choosing organic not only preserves the Earth's resources and protects the health of the farmers, but ensures that what is going into our bodies is 100% natural, made the way nature intended.
Heatlth Benefits of TeaMore than 200-300 independent health studies have been conducted related to the benefits of tea. Most have been on green and black teas. Tea is rich in polyphenols, tannin, and flavonols (often termed catechins), fluoride, and vitamin C, P, K, and B. Although tea contains caffeine, the amounts are far less than those in coffee and produce a softer, beneficial effect. Studies suggest that as few as four servings of tea a day may have a positive impact on your health.
Antioxidant PowerhouseAntioxidants in tea are able to neutralize the damaging effects of oxygen and free radicals that are present in the body. Antioxidants slow or prevent cell damage from exposure to oxygen by creating a barrier around cell tissue. Recent studies show that polyphenols found in green tea appear in greater concentrations in white tea, helping to destroy bacteria and other organisms that cause disease. Recent studies show that polyphenols found in green tea appear in greater concentrations in white tea, helping to destroy bacteria and other organisms that cause disease.
Skin ProtectionThe EGCG rich polyphenols in green tea protect skin from ultraviolet radiation damage, preventing skin tumor formation. The same compound is found to inhibit enzymatic reactions that break down collagen and elastin in skin.
Cancer PreventionGreen Tea has been found to inhibit the growth of esophageal and stomach tumors in mice. Green and black tea could inhibit the development of pre-cancerous lesions as well. A recent study showed that a compound in black tea called TF-2 caused colorectal cancer cells to "commit suicide"; normal cells were unaffected. Present at higher quantities in green tea, the antioxidant epigallocatechin gallate (EGCG) is the focus of cancer research worldwide and identified by scientists as a cancer-fighting compound. One Japanese study highlighted a reduction in the growth of human lung cancer cells after the consumption of two to three cups of green tea.
Improved Cardiovascular Health and Reduced Risk of StrokeA study undertaken found that of 340 men and women who had suffered from heart attacks, those who drank a cup or more of black tea daily had a 44% lower risk of repeated heart attacks compared to non-tea drinkers. Flavonoids in tea are theorized to improve the lining of blood vessels, which may account for the decreased risk. Studies show that drinking black tea helps to prevent narrowed or clogged arteries that lead to ischemic heart disease, heart attack, or stroke.
Reduces "bad" CholesterolOne study suggests black tea to reduce LDL-cholesterol ("bad cholesterol"). Tea polyphenols may limit the absorption of cholesterol in the intestine, thus reducing the cholesterol levels in the blood. Reducing "bad" cholesterol LDL deposits, tea elevates HDL, or "good" cholesterol. Green tea, particularly oolong, may prevent arteriosclerosis.
Oral Health and Prevention of Tooth Decay and Bad BreathFlavonoids (mainly catechins) found in green tea, have exhibited inhibitory effects on the growth of cariogenic bacteria by inhibiting the adherence and growth of plaque bacteria at the tooth surface. Polyphenols found in both green and black tea can block bacteria from producing foul-smelling compounds such as hydrogen sulfide in the mouth. Studies show the tannin and fluoride content present in tea prevents tooth decay.
Arthritis PreventionGreen tea may inhibit the development of arthritis. In one study, mice given green tea polyphenols were significantly less likely to develop arthritis. The study was conducted on 36 mice. Of the 18 mice that received the green tea, only eight (44%) developed arthritis. Among the 18 mice that did not receive the green tea, all but one, or 94% developed arthritis.
Burns CaloriesGreen tea's antioxidant EGCG may stimulate the body to burn calories, notably fat. In a recent study, a daily dose of 270 mg EGCG (the amount 2-3 cups of green tea) caused men to burn 4% more energy – about 80 extra calories a day.
Green tea extract has been shown to significantly increase energy expenditure (a measure of metabolism) and may have a significant effect on fat oxidation. Efficacy of a green tea extract rich in catechin polyphenols and caffeine in increasing 24-h energy expenditure and fat oxidation in humans.
Reduced Risk of Kidney StonesIn a study of more than 81,000 women 40 to 65 years of age, it was concluded that 8 fluid ounces of tea consumed daily actually lowers the risk of developing kidney stones by 8%. Furthermore, tea acts as a diuretic, stimulating the flow of urine), promoting better kidney function and aids digestion.
Slows the Aging ProcessIt has been shown that Green tea reduces infection and the stresses of bacteria on the system thus significantly retarding the aging process.
Immune BoosterBlood cells from tea drinkers respond 5 times faster to germs than those of coffee drinkers. One way to measure the strength of an immune system is to measure the production of antibacterial proteins in the body. Higher levels of these proteins are associated with healthier immune systems that are better at warding off illness and disease than a weak one. A study comparing the production of these proteins in coffee and tea drinkers found that the group drinking 2.5 cups of black tea per-day exhibited production levels that were five times higher than those of the coffee drinkers. "Antigens in tea-beverage prime human Vgamma 2Vdelta 2 T cells in vitro and in vivo for memory and nonmemory antibacterial cytokine responses"
Holds Promise as HIV TherapyEpigallocatechin gallate (EGGG), an active ingredient in tea, has antiviral, antioxidant and antibacterial properties that are now being studied in hopes that it helps inhibit the HIV virus.
Experience the Numi Difference Quality & AuthenticityYou'll find Organic Full Leaf Teas, Fresh Herbs, and Real Fruits in our tea bags for an authentic rich natural taste. We don't believe in the common practice of adding oils or flavorings to bolster flavor.Communitea Your purchase of this Fair Trade Certified tea guarentees that workers are provided a fair wage leading to an improved quality of life.SustainabilityNumi is committed to environmental responsibility. This carton is made of 100% recycled material and the tea bags are made of.
Numi's ValuesCelebrating PeopleNumi is eclectic individuals who encourage each other to be ourselves while celebrating their differences and similarities. They have a generous spirit and infuse kindness and respect into all of their interactions.Nurturing GrowthNumi provides a learning culture and supportive environment that encourages personal enrichment and expects professional growth as they collectively strive for excellence.Embracing PossibilitiesSteeped in innovation, they are forward-thinking, open-minded and willing to take risks. Entrepreneurial in their approach, Numi embraces promising ideas and creatively realize them as a tea'm. Each of them has the responsibility to share our ideas and ask, "What if?"Be the ChangeNumi are obligated to create a positive impact on the planet and the communi'tea. Positive change is achieved through inspiration, transparency and consistency of words and actions. They focus their energies on finding solutions.
Choice of WaterThe perfect cup of tea begins with fresh and clean water. To preserve the delicate nuances of tea's flavor and aroma, it is best to avoid using tap water which can contain chlorine and fluoride. Instead, opt for filtered water and spring water for the perfect brew.
Method of SteepingIf you are brewing tea from loose leaves, we recommend using two grams of tea per six ounces of water, or one heaping teaspoon per cup. If you are using a lighter, bulkier tea like a spring white or tippy black, a larger amount by volume should be used. Try a tablespoon per cup. While steeping loose leaf it is important for the water to flow freely through the tea. Tea balls can constrict and break the leaves, resulting in a weaker cup. Try using a basket-filter, tea sac, or even letting your leaves free in the bottom of the pot and filtering the infusion when the steeping is complete.
Water Temperature and Brewing TimeThese general recommendations for water temperature and steeping times provide a good starting point for brewing an unfamiliar tea. Over time, you may find that you like to use warmer temperatures times for one varietal, while cooler water and a longer steeping works best for another. Only experimentation and tasting will determine what you need for your perfect cup.
Water Temperature:White Tea: Just under boiling (170-185 F)Green Tea: Just under boiling (170-185 F)Oolong Tea: Just under boiling (170-190 F)Black Tea: Boiling (200-212 F)Pu-erh Tea: Boiling (200-212 F)Herbal Teasan: Boiling (212 F)
Steeping Time:White Tea: 2-3 minutesGreen Tea: 2-3 minutesOolong Tea: 2-3 minutesBlack Tea: 3-5 minutesPu-erh Tea: 2-3 minutesHerbal Teasan: 4-5 minutes
Iced Tea made from Numi Tea Bags
1 GLASS (16 oz.) ICED TEA:Steep 2 teabags of your choice of Numi Tea in a heat resistant glass/cup in 8 oz. hot water for 5 minutes.Fill separate glass with ice. Pour hot tea over ice and top off with more ice. Enjoy!
1 PITCHER (32 oz.) ICED TEA:Steep 4 teabags of your choice of Numi Tea in a heat resistant glass/cup in 16 oz. hot water for 8 minutes.Fill separate pitcher with ice. Pour hot tea over ice and top off with more ice.
Fair Trade Certified organic Mint.
All tea is gluten-free.
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These are definitely cute boots, and about what I anticipated for the price. The quality isn't the best, but again, what I expected. The material is nice, pretty thin, but the upper part is lined, so they have a nice shape. From the picture, I expected the buckles to be gaudy gold, and was planning on painting or replacing them, but they're actually brushed metal, and not bad looking at all. I have average-width feet, and wear a 7.5 to 8 in sandals and 8 to 8.5 in shoes/boots, so I ordered the 8.5 in these. They definitely run SMALL; my toe is touching the end. I'm wearing them around inside for a while before I decide if I'll keep them--most likely I will, because returning is such a hassle--but I definitely will never be able to wear thick socks with them. I would recommend ordering a size up from what you normally wear! In other news, these boots have ZERO support. I mean *none*. They are absolutely flat, and the sole is really thin. I've been wearing them inside for about a half hour, and my feet already hurt a lot. Plan on buying good arch support inserts for these. Overall, very cute looking boot, average quality, disappointing comfort level, great price...and again, they run small. Buy a size up and some inserts, and you'll be all set!!
The boots are quite a bit shorter than I was expecting, but only because they slouch A LOT more than the picture shows. When pulled all the way up, they do look like the picture, but they will not stay up on my leg. The fabric used for the boots is thin so its not sturdy enough to stay up on its own. I still do like the boots for what they are, but its just not what I was expecting from the picture.
These boots are very cute and stylish. I wear them with jeans to look casual and they also look great with tights and a dress. Two drawbacks, they are cheap so they're not the best quality and the soles are fairly slippery. If you live someplace with snow and ice, you may want to consider having the soles replaced - pretty cheap thing to do. Overall - great purchase, I'm VERY satisfied with them!
They look even bettter in person than on the screen. I get compliments every time I wear these!!
I actually returned this item because I didn't like the quality of them. The material appeared cheap.
Comfortable nice looking flat sole boots. Not sure about how they might hold up with frequent wear, will see, but I do like them and actually got two pair,
The product would've been fine, if they were the same boot. One boot was about 5 inches taller and the throat had 2 to 3 more inches of girth. These are almost two entirely different boots and look ridiculous as a pair. I'll definitely warn my friends and coworkers away from this site. A low price for an unusable item is wasted money.
These boots are very casual, yet dressy. They are a good fit and nice size/width. They are a great buy!
Runs a little small so up your size by one Beautiful boot waterproof needed
I love these boots, I just ordered another pair. They are very contoforable
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Dear Lauri,
Last night I dreamed I was part of a group of people sent to a lady's home because she was being harassed by "ghosts". Turns out the "ghosts" were neighbors dressed up in wool ghost costumes trying to scare her out of her house. We had fun driving the people in ghost costumes out. It was all very Scooby-Doo. After we got rid of the "ghosts" the lady of the house was able to return to her garden, which is where I woke up. – Chris 38, Salem, MA
Lauri: Is there anything that has been bothering or "haunting you" lately, something that turned out to be not what you thought, and in fact not as bad as you thought? Since you were in a group in the dream, this may be connected to a waking issue that involves several people rather than just you. Also, the ghost's costumes were made of wool. That's a significant detail. Has anyone been trying to pull the wool over your eyes lately? Or have you gone in to some issue or project "blind" so to speak? In the dream you were able to get rid of the ghost imposters, which suggests in real life you have been able to rid yourself of this bothersome issue. And the lady being able to get back to her garden may really be the way your dreaming mind is telling you, now that this issue is over with, it's time to get back to more productive and fruitful things in your life.
Chris replies: I had a big project at work that wrapped this past weekend. I did go in somewhat blind and with a "who knows" attitude. It all could have been a wreck but it turned out smoothly and yes, I do have other projects I can now and should focus on. Thanks!
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Alfred Angelo
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My Ear-Trumpet Has Been Struck By Lightning
Common-place Book
of the
Mercurius Aulicus
, a Reactionary Tory Gentleman, who armed only with a Steampowered Babbage Engine and Pure Intentions, wanders the Time Streams and Aetheric Plane gathering an Eccentric Hodgepodge of Curiousities, Frivolities, Whimsicalities and Nonsense.
Q. Why is your Tumblelog called "My Ear-Trumpet Has Been Struck by Lightning"?
A. Because "My Grandmother's Ear-Trumpet Has Been Struck by Lightning" wouldn't fit in the available space.
Enquire Within
Enquire Within


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NHL™ Folding Insta-Set® Goal, Stick, and Ball Set
6 years & up. Make every goal with this official NHL™ folding hockey set! Great for indoor or outdoor use. Set includes 2 goals, 4 player sticks, 2 goalie sticks, and 4 soft EVA foam 2" mini balls. Fully assembled, goal sets ups in seconds, and comes packed in a durable polyester carry bag for storage and transport.


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Mada, that so sucks for them............ and you, you must be run off your feet.
I understand the thing about the shots. Both the pediatrician and I had promised Finn no more shots after his 4 year old ones (always a horrible shock to the system) until he was much older (except if he was sick)! This of course predated the availability of flu shots for kids. So I asked her what she was going to do about her promise (also made to her own son, Finn's age). She said, "apologise for breaking my promise and bribe my way out of this". So we went the same route. He was very reasonable about it, particularly when we asked him if he'd rather be sick in bed and not playing with his friends, or a prick like a little bee sting. He chose the sting. We also took him to see mom and dad getting theirs. He really, really enjoyed that!! It is really hard to see them getting stuck, but an efficacious vaccine over the real disease is always the best route. I know that Children's hospital here is full of kids with flu and even has kids in the PICU. Previously fully healthy kids too, not kids with asthma or some other predisposing factor. Heck, if a shot will prevent that, then I'll be a meanie mommie!!
Catherine (37)
DH, Dave (40)
Finn (6)
Lucy (2)
Chloe (7/2/03)


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Deftones are pleased to announce they will be performing at Chiemsee Rocks! Festival in Ubersee am Chiemsee, Germany on Wednesday, August 21. Tickets are now on-sale and can be purchased, HERE.
Deftones will be performing at The Orion Festival in June at Belle Isle, in Detroit, Michigan. Pre-sales will begin tomorrow, February 26 at 10am local time and general on-sale is Friday, March 1 at 10am local time. For full details click, HERE.
Deftones will be performing at Two Days A Week Festival in Wiesen, Austria in August, as well as Rock Altitude Festival in Le Locle, Switzerland on August 16. Tickets can be purchased for these festivals at the links below:
Rock Altitude Festival: http://www.rockaltitude.ch/tickets.html
Two Days A Week Festival: http://www.wiesen-festivals.at/two_days_a_week
Deftones will return to Paris, France on Friday, September 6 for a headlining performance at Le Zenith. Tickets will go on-sale this Friday, February 22 at 10am local time, HERE.
Tickets are now available to purchase for this year's Carolina Rebellion festival on 5/4. Tickets are also now on-sale for the recently added Deftones headline shows in in Oklahoma City, OK on 4/28, Springfield, MO on 4/29 and St. Louis, MO on 5/1. For full details and to purchase tickets, click HERE.
Deftones will be performing at this years Carolina Rebellion festival on Saturday, May 4 in Rockingham, NC. Full line up can be found HERE. Additionally, the band will be playing headline shows in Oklahoma City, OK on April 28, Springfield, MO on April 29 and St. Louis, MO on May 1. Pre-sale tickets for these headline shows are now available to purchase HERE. General on-sale is Friday, February 8 at 10am EST.
4/28 Oklahoma City, OK Diamond Ballroom
4/29 Springfield, MO Gillioz Theater
5/1 St. Louis, MO The Pageant
Deftones will be performing at the first ever Ozzfest Japan on May 11. Tickets are now on-sale to purchase HERE.


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Win "Martha's Entertaining: A Year of Celebrations" on the Ehell blog! Entries close May 11th.
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Florida here, and about a 10-15 minut drive from the Atlantic ocean. We run the AC from about March to November. It's *just* getting cold enough to need the heat at night. And we have to run it too-the amout of humidity in the air in summer is horrible. I give up doing hair/makeup if I'm doing more than going home-car-school-car-home because it would be ruined in 2 minutes...
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For the second post in a row, I can't compose a clever headline.
[Photo: courtesy of East Central University athletics]
Chris Lane grew up in Melbourne, Australia. He came to the States to play baseball, first at Redlands Junior College, then at East Central University in Ada, Okla. He started 14 games behind the plate last season and was entering his senior year. He wasn't a spectacular player -- he hit .280 with five doubles and four HRs, according to the team website -- and may never have played professionally at all, certainly not at a high level. His coach, Dino Rosato, described him as "an absolute joy" to coach, a well-respected student-athlete who was a great supporter, adviser and example to his teammates.
While he may not have found a lifetime career in baseball here, Lane found an education and may have found a life beyond it. Sarah Harper was Lane's girlfriend They had just returned from a visit to Australia and Harper took him home to Duncan, Okla. Lane went out for a run.
He jogged past a home where three teenage boys were staying. At least one would tell Stephens County authorities that the teens were "bored" and decided to kill someone. One proclaimed "There's our target" when Lane passed by.
They followed him in a car. They shot him in the back. They drove off.
Lane staggered and fell to the ground. Those who heard the gunshot tried to help, even administering CPR. Chris Lane died on the scene. He would have turned 23 on Labor Day.
[Photo: Lane and Harper, via Twitter]
I consider myself a smart man, but there is no understanding this. They murdered a stranger -- someone who never even had a chance to wrong them -- in cold blood. I know I'm supposed to use words like "allegedly" here, but they've admitted to it, according to all accounts. They shot a defenseless man in the back because they were "bored."
Is there anything more cowardly than shooting someone in the back?
Is there anything more evil than doing it just for fun?
I so want to make sense of this, but I know I never will. I am profoundly saddened by this loss of someone I never would have even met. I could only hope to someday take this as well as the victim's father, Peter Lane.
"It is heartless and to try to understand it is a short way to insanity."
God bless Chris Lane.


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George is a typical 17-year-old. He likes sports, action movies and spending time with friends. However, there is something else that really revs his engine.George has a need for speed and really loves being active. That is why we brought him to JD Indoor Karting in Novi.He likes all sports, including basketball, football and baseball, as well as things like skating and travel. He is fun and easy going, the kind of person people like to spend time with."I've been working with George for almost a year, and every time I've been with him, he's always making me laugh. He's always smiling. He's an absolute joy to be around," said Amanda Pasionek, an adoption resource consultant.George is one of a hundred children featured in a special traveling exhibit called the Michigan Heart Gallery. It features photographs of the many kids in our state waiting to be adopted by a loving family."It's amazing when you look at the exhibit how you can see little pieces of the personality that come through these photographs," said Michelle Parra from the Michigan Adoption Resource Exchange.George is a terrific young man with a great personality. He has a lot to offer, and he is still hoping to find a loving family so they can share life's adventures together."I will be there for people, and they will be there for me, so I like to help people out and care for them," George said."George hundred percent wants a family. He hasn't given up yet, so I just really want to find a family for him and complete his dream," Pasionek said.To learn more about George, call 1-800-589-6273.The 2013 Michigan Heart Gallery grand opening is Saturday, April 20 from 11:00 a.m. until 2:00 p.m. at Jamison Temple Baptist Church in Detroit. Representatives from local adoption agencies will be on hand to answer any questions you might have about adopting a child.RELATED LINKS:Michigan Adoption Resource Exchangewww.mare.orgMichigan Heart Gallerywww.miheart.org
KSAZ-TV & KUTP511 W. Adams St.Phoenix, AZ 85003Phone: (602) 257-1234Fax: (602) 262-0177


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I wandered on over to Bouchaine Vineyards today. Actually, I had wanted to go and finally take a picture of that big old winemaker statue on the outskirts of Napa, but I blew right by it. Guess I should have taken the righthand fork toward Lake Berryessa. Anyway, I decided to head to Bouchaine Vineyards instead because their '97 Pinot Noir was one of my vinous epiphanies. I know, Thomas Wolfe, but it was really a pleasant ride all the same.
I pretty much tasted through their whole line-up (what was left of it this late in the season), i.e. Buchli Station label, Chards, Pinot Noir, Syrah, Rosé of Syrah, and a funky dessert wine called Bouche d'Or which was a really tasty blend of Chardonnay and, of all things, Riesling. That was a truly unctuous event with a heavy-fruit-syrup-like mouthfeel and a spritely, exotic fruit flavor I couldn't put my finger on, pear-ish or kiwi-ish. It was, however, unique and I would have bought a bottle were I not such a skinflint.

Then I had a pre-release drop of their '05 Chêne d'Argent, an unoaked Carneros Chardonnay. I asked and believed to hear that no ML was involved either. Bright, crisp, light and lively, full of fruit with bouncy acid. Geez, I might even start drinking Chardonnay again. The folks at Bouchaine like to translate that French name into "Silvery Oak" in reference to the stainless steel fermentation and ageing. I, cynic that I am, kind of leaned toward a looser translation, "Money Tree."
In all, I have to say that winemaker Michael Richmond had a wonderfully light hand. Only the '04 Carneros Pinot Noir seemed too oaky for my taste, but it doesn't take too much oak to turn me off. Otherwise these were real dinner wines, subtle and none too pushy. Even the Syrah was on the light side. All that bacon and all those "lardons" were left in the fridge. OK, blind one might not have recognized it as Syrah, but it was good. The pourer said it was a Syrah made in a Pinot Noir style. He might have been right.

Lastly, get there soon. The tastings are still complimentary. They'll be charging soon ... just to keep the riff raff out. Guess they meant me!


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Posts published by Simon Johnson
22 Results
A Few Good Chairmen
Short-Seller Shows a Knack for Deals
Nationalize? Hey, Not So Fast
BNP's New Offer for Fortis Faces Same Opponents
An influential adviser urged shareholders on Sunday not to support the latest offer for Fortis, the Belgian financial services company, by the French bank BNP Paribas, even as executives at the two companies expressed confidence that the deal would succeed. Read more…


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Northern Ohio Violent Fugitive Task Force is offering a reward for information
which would lead to the capture of fugitive Basim Barnes.
is wanted by the U.S. Marshals and Bureau of Alcohol, Tobacco, Firearms and
Explosives for being a
felon in possession of a firearm. The
firearm was discovered by the Cleveland Police following a traffic stop.
is described as a 28-year-old black male standing approximately 6 feet tall and weighing 176 pounds. He has black hair and brown eyes.
He is believed to be hiding somewhere in
Cleveland and also has a previous
address near the 1300 block of Crestline Avenue in Cleveland.
Anyone with information regarding the whereabouts of Basim Barnes is encouraged to contact the NOVFTF at 1-866-4WANTED or text keyword "WANTED" with the tip to TIP411. Tipsters may remain anonymous. A cash reward may be available.
Copyright 2013 Toledo News Now. All rights reserved.
P.O. Box 3130
Albany, GA 31706
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(229) 446-4005
EEO Report
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Major changes to Renewables Obligation scheme deliver huge boost to marine and offshore wind energy
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A discussion of the "risk perception gap", its implications and how it can be closed
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Quick Links
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Use Oriana alphabet letter beads to create coded messages or simply spell out a name on your bead bracelet! Once you've spelled out the name or word you're interested in, try adding other style beads to add your own touch to your bead collection!
Spell out just how you feel with our Oriana bead alphabet bead collection! Our Oriana beads are Pandora bracelet compatible, so you can add them to your existing collection. With almost every letter, from A to Z, you can spell out just about anything you'd like (as long as its not too long for your bead bracelet or bead necklace)! These letter beads will spell out your heart's desires, or your favorite nickname.
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Governor Jan Brewer is back in Arizona after attending the Super Bowl. She flew on a private jet with an Arizona Cardinal and an actor who has been an outspoken critic of SB 1070.
We've learned the man who funded that flight may have some questionable business practices.
Larry Fitzgerald tweeted a photo of all of them, and that's how we found out about this trip.
Governor Brewer says she paid for her own Super Bowl ticket, but her flight on a private jet was a gift. A gift from valley businessman, Jason Hope.
Two years ago, Hope was sued by Verizon after he was accused of misleading cell phone customers.
In the photo, you can see Governor Jan Brewer, with actor Edward James Olmos and athlete Larry Fitzgerald to her left. To her right is Scottsdale businessman Jason Hope.
"He is a pretty prominent individual in Republican circles, he's become an acquaintance of the governor and I believe that how they came into contact," says Matt Benson, Governor Brewer's spokesperson.
Hope's business practices have been questioned in recent years. Hope owns a cell phone marketing company which has been accused of a complex business scam. Hope was sued in federal court by Verizon. That suit was settled last year.
"I don't know what level of awareness she has of that," says Benson.
Hope was also sued by the Texas attorney general. He settled that suit for $2 million. A business associate of Hope's told us she's surprised to see Governor Brewer accepting a gift from Hope.
"He is not a lobbyist so there's no problem here, now if the expense is in excess of $500, she does need to report it," says Benson.
Actor Edward James Olmos was also invited on the jet. A few years ago, he was critical of the state and spoke out against SB 1070.
"They had a great time. I know the governor told me she enjoyed spending that time with him I don't believe that they had met previously. You know, this trip was more about football than politics."
Hope has never faced any criminal charges. He calls himself a philanthropist and has donated to various charities around the country. We're told that Hope invited Olmos because they've done some charity work together.
A private jet to New Orleans costs at least $10,000 each way. She's required by law to disclose the jet ride.
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Emma's Q & A
Favorite Sport/Team
Anything New York!! But favorites Mets & Ny Giants
Favorite Movie/Actor
Ryan Gosling
Go-to karaoke song
"Call me" Pat Benatar
My first job
Ice cream scooper
Piercings/Tattoos (How many? Where?)
Piercings: Nose and Belly Tattoo: 1 on rib cage (hidden, and only shown to a lucky few;)
Mac or PC?
Nintendo, Xbox 360, PS3, or don't game?
Nintendo Duck Hunt...best game ever:)
What fun fact, talent or superpower of yours should guys know about?
hmmm...not too talented (besides being a dancer/actress/model), but I can shoot whisky better than any girl/most guys
What's the most memorable pick up line you've ever heard?
You look a lot like my nEXt girlfriend. Com'on guys you can do better than that...
What's the craziest thing you've ever done?
Probably an impulse sky diving trip. So very worth it!
What's the most unusual place you've ever hooked up? How'd it go?
Probably a balcony in Mexico. Tequila induced :)
What's in your purse or pocket right now?
Wallet (with lots of money:), perfume (gotta always smell delicious!), and gum!
What do you feel most comfortable wearing?
Sweats, especially when they are boys sweats:) They feel so much more comfortable!
Would you rather have boring sex all the time or an amazing romp once a year?
Neither! But if I really have to choose amazing once a year.
If you could do a shot of Jose Cuervo with anyone -- dead or alive -- who would it be?
I wouldn't mind seeing what drunk Marilyn Monroe was like.


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Madison Heights detectives are beginning to investigate the criminal complaint against Charles Pugh filed over the weekend by a mother and her teenage son.Police would not talk on camera or release copies of the complaint, but we were told it accuses Pugh of inappropriate contact with the teen on a day when he took him out of school and shopping without his mother's permission."I feel that he was luring my son with gifts, money and promising him things, and that's luring, that seducing," the mother told Fox 2's Charlie LeDuff late last week before the complain was filed.Investigators told us there are no specifics, and so far the information does not meet the criteria of a crime.Police told us the complaint involves an alleged incident that took place in Madison Heights in a parking lot between May 29 and May 31. At that time, the student was 18 years old. Police said they have a lot of questions before they can determine whether a crime took place.Next they will want to bring the teen in for questioning and talk to Pugh, who was last spotted in a Seattle coffee shop on Friday. It is not known where he is now or when he will return to Detroit."It appears to me like something is just not right here, but yet I still don't understand why Mr. Pugh felt like he had to leave. That part I don't understand," said Mary Williams.She said her 13-year-old son had a positive mentoring experience with Pugh. Williams is one of several people who have contracted Fox 2 to vouch for the City Council president and his behavior with students."When Mr. Pugh mentored my son, he was appropriate with him. Anytime he wanted to do something with my son, he contacted me," Williams explained.She said she never had any reason to worry, but the mother making the allegations against Pugh tells a different story. Sources said the family is in the process of changing lawyers.Police said once the investigation is complete, they will forward the report to the Oakland County prosecutor.
On June 29th, 2013 an 18 year-old male, accompanied by his mother, filed a complaint at the Madison Heights Police Department. The complaint alleges that Charles Pugh had inappropriate contact with the 18 year-old male while in the City of Madison Heights. The incident reported is alleged to have occurred between May 29th, 2013 and May 31st, 2013. The complaint has been assigned to the Detective Bureau. The investigation is in the preliminary stages and due to this we cannot comment on any details contained in the complaint. We will issue an updated press release as the investigation progresses.
WTTG FOX 5 & myfoxdc5151 Wisconsin Ave. NWWashington, DC 20016Main Number: (202) 244-5151Newsroom: (202) email@example.com


text: October 18, 1976 Mr. Thomas R. Wilcox Chairman of the Board Crocker National bank One Montgomery Street San Francisco, California 94104 Dear Tom, Many thanks for your kind letter of October 13. Your sentiments are very much appreciated. The work that remains to be done is the holding of shareholder meetings by G. E. and Utah International on December 15 and the closing of the transaction on December 20. This is not too generous a time schedule and the role that the bank might play in facilitating it is primarily to be sure that its Trust Department gets its proxies in diligent fashion. In this respect Crocker is relatively more important than most of the other banks because of the Utah stock that is in the bank. On some of this I am a co-trustee but in other instances it is the bank that must contact the beneficial owners. With best personal regards, EWL/nf P.S. You might also have your secretary correct her record of company name and title.


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Fast-n-cheap or four-course finery? Your dining style on the road ...
Always on the go and ready to rush off to the next big thing, the Ram will most likely grab some fast food en route. When dining in a restaurant, try a variety of appetizers, which will suit your investigative nature.
The Epicurean Bull will most likely be found savoring succulent three-course meals at posh five-star restaurants. Surely dessert will be one of the three courses -- or will it be the fourth? -- as you have quite a sweet tooth.
The intellectual and airy Twins like to keep dinner light. While fast food will do, you're also willing to broaden your horizons by trying different types of food.
A homebody at heart, the Crab enjoys a good home-cooked meal or take-out. Due to your delicate tummy, you may not be too inclined or advised to try different cuisines.
As the King or Queen of the Jungle, the Lion opts to dine in the sort of restaurants that befit royalty -- those of the five-star variety. Three-course meals in the best restaurants in the world are right up your alley.
The picky Virgo is equally picky in all aspects of life, including food and dining. A finicky eater, you'll insist upon eating well-balanced, healthy meals that won't pollute your body.
The well-mannered Libra brings refinement and charm to an equally sophisticated eating establishment. Five-star dining in the best restaurant around is right in style with your tastes.
The tenacious Scorpio prefers to keep a routine and not be bothered with big meals, which might take them off course and off their itinerary. Your strong constitution will enable you to try a wide variety of dishes.
Adventurous and enthusiastic, Sagittarius will satisfy their appetite not only for food but also for excitement by dining on foreign cuisine. The more exotic the cuisine, the better; you'd get bored with a meat-and-potatoes type of routine.
The hard-working Goat will be cautious when it comes to parting with their hard-earned pennies. A five-star restaurant that has great food at a great value is your dream dining experience; whether it exists or not is another question altogether.
Original and inventive, the Water Bearer seeks out new and different foods if they're not cooking up some new creation on their own. Your eccentric and intellectual nature will lead you to sample exotic foods from the world over.
Dreamy and romantic, the Fish will please their palate with an assortment of cuisines. If you can't actually go to Tuscany, at least your mind can travel there, given the proper, fantastical dining experience.
Learn to analyze your astrological identity with a free sample Astro Analysis Reading from Astrology.com.
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22 April 2012
Posted in Earth Day
Sometimes, it's easy to think that it takes a huge effort to change the environment. In reality, it only takes a few small steps from everyone. Here are ten things you can do today to help conserve the air around you!
- Combine errands to reduce "cold starts" of your car and avoid extended idling.
- Shop by phone, mail or Internet.
- Avoid waiting in long drive-thru lines, for example, at fast-food restaurants or banks. Park your car and go in.
- Accelerate gradually, maintain speed limit and use cruise control on the highway.
- Keep your tires properly inflated and aligned.
- Fill gas tank during cooler evening hours to cut down on evaporation.
- Avoid spilling gas and don't "top off" the tank. Replace gas tank cap tightly.
- Don't ignore the "check engine" or "service engine soon" light if it comes on. Make an appointment with your repair technician for diagnosis soon.
- Replace your car's oil regularly. Use an energy-conserving (E.C.) grade of motor oil.
- Replace your car's air filter and oil regularly.


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Contact our free concierge and we'll make a vacation work for you. (877) 372-5877 | Email Concierge
Book it now, and be on your way! With Room + Perks, your reservation is made with the hotel the moment you complete your purchase.
You tell us when you want to travel, and the length of your stay, and we'll only charge your credit card if we can confirm your requested dates.
Chalet Package for 2 TravelersOnly available through Luxury Link...
- Roundtrip transfers between Mkuze Falls private airstrip and the lodge
- Breakfast, lunch and dinner for two each day, including afternoon tea and game drive beverages
- Morning and evening game drives each day
- Bush walks by request in the Private Big Five Reserve
- Taxes
- 1 king bed or 2 twin beds
- En-suite bathroom and full air conditioning
- Private plunge pool and outdoor shower
- Private deck with river and bush view
Amenities, Activities, & Attractions
- Fishing
- Hiking
- Wildlife Viewing
- Bird Watching
- Game Drives
In-Room Amenities
- Air Conditioning
- Ceiling Fans
- In-Room Safes
- Mini Bar
- Coffee & Tea Facilities
- Outdoor Showers
- Private Pools
- Private Decks
On-Site Amenities
- Pool
- Laundry Service
- Heliport
- Live Entertainment
- Lounge
General Information
- 15 Guest Rooms
- Meeting Rooms
- Outdoor Dining
- Dining Room
- Active & Adventure
- Food & Wine
- Summer Getaways
Mkuze Falls Private Game Reserve MapPO Box 238 Pongola 3170, KwaZulu-Natal, South Africa 27-34-414-1018 Nearest Airport: JNB Display Map
Alert Me
Email me when a new vacation package becomes available for this property.
Contact Mkuze Falls Private Game Reserve
Book Direct: Mkuze Falls Private Game Reserve


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2 Plate Multidish $182
Maxime Ansiau has squashed the conventions of traditional Delftware in the most graceful way. Her Multidish available at Seletti depicts classic Dutch scenery like countryscapes dotted with windmills on plates linked together in rows of two or more with new functional and decorative implications.
Jacobsen Salt Co
Artisan Sea Salt Slide Tin $3
Harvested from the cold waters off the coast of Oregon, Jacobsen Salt Co's beautifully flakey crystals strike the perfect balance between earthy minerality and full on salty ocean flavor. Loved by chefs like Thomas Keller (Per Se) and April Bloomfield (The Spotted Pig), Jacobsen's salt has the refinement of centuries-old fleur de sel with the zing of new American enthusiasm.
Chiaverini Cherries Jam $10
With packaging as sweet as its contents, Chiaverini's canned jam makes for a pleasant little foodstuff gift. Available at the equally adorable and sophisticated London shop, The Hambledon, the brand's Florentine origins date back to 1928.
Bairro Alto
AltoAir $58
The AltoAir pour-over coffee filter combines form and function, Made in the UK from 100% stainless steel, AltoAir overcomes the problem of paper filters sticking to the brewer, resulting in inconsistent extraction.
Glass Food Storage $15+
These BPA-, BPS- and phthalate-free glass containers come in a variety of sizes and with its own colorful silicone sleeve that uses button tabs to secure on the lid. They're safe to use in the oven, microwave, freezer and dishwasher, making lunches and leftovers easier and more attractive than ever before.
Hands Baggu $9
Baggu's ingenious design makes for the most functional and stylish eco-bag out there. Joining their line of of reusable shopping bags this season is a new "hands" print, which with peace signs and shaka signs, spreads the good vibes while on the move.
Jackson Pollock Chocolates $32
Chocolate and art might be two of life's most enduring superfluous pleasures, and Mexican design group Unelefante marries the two impeccably. The Pollock Chocolates come in a set of three bars of 54% Colombian cacao, handpainted with Jackson Pollock-inspired strokes of vibrant color.
Crispin Finn
Cocktail Tea Towel $19
Drink devotees will never reach for the recipe book again when they have these Cocktail Tea Towels from our friends at Crispin Finn. Each screen-printed, 100% cotton towel includes the recipe and history for a concoction of choice, and perhaps most importantly, an enlightening quote reminding us of the health benefits of any given spirit. All leaving no doubt in our slightly buzzing brains that we should most definitely mix up another one.
Suck UK
Frozen Peas Ice Cube Mould $15
Suck UK smartly looked at nature to devise the perfect ice ball-maker. Crafting a jumbo-sized pea-in-a-pod design, the designer's Frozen Peas make it easy to squeeze out a giant ball of ice, which melts 80% slower than cubed ice, for cold, strong drinks.
Shaw Sisters
Wood Trio $38
Shaw Sisters worked with artisans in Kwazulu-Natal, South Africa, to create this kitchen set that consists of a spatula, and a large and small spoon. The wooden pieces are blasted with a catalyzed laquer to give a shiny, durable finish, and a dash of color.
Maldon Sea Salt Flakes $11
Make your tastebuds really sing with the decadence of Maldon Sea Salt. Derived the same way since the company started raking underwater salt beds in 1882, the unprocessed crystals retain natural trace elements that make the compound more flavorful—therefore requiring less. If a sprinkle of the white stuff is one of life's little pleasures, ramping up your salt game in the kitchen will pay dividends to your daily satisfactions.
Tim Love for Sur La Table
Himalayan Salt Tequila Shot Glasses $40
No need to salt the rim when your glass is hand-carved from a single piece of pink Himalayan salt! Just add lime and enjoy!
Crate and Barrel
Awning Stripe Paper Beverage Caddy $8
Pack up your home brews or an assortment of your favorite craft beers in this paper drinks caddy. The "awning stripe" adds an element of refinement any time of year.
Saikai Toki
Crane Grater $46
The Saikai Toki Crane Grater elevates a kitchen tool to extraordinary elegance. The small plate features micro ridges in 100% copper across the bird's belly for precise fine grating while cooking.
Sebastien Guenard + Marion Billet
Big Meals for Little Hands $18
Kids get equal access to the healthy, gourmet recipes of Michelin-starred French chef Sebastien Guenard in a colorful cookbook. Illustrations by Marion Billet help young cooks learn about sustainable and environmentally conscious cuisine, so they end up having fun with food while learning best practices at an early age.
Authentic New York Hot Dog Vendor Cart $5,500
Ever since 1936 when Oscar Mayer rolled out the Wienermobile, the first mobile hot dog cart, sausage vendors have become an inextricable part of America's urban centers. This high-quality vendor cart is modeled after the same found on the streets of New York City and is perfect for backyards or business opportunities.


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Experienced runners know that quality active wear and dedicated running tights improve the experience and extend the comfortable range of weather that you can call suitable for running. Stretch sport tights and loose fit tights keep your muscles warm and improve your performance.
As running shoe companies, it is natural for Pearl Izumi and Saucony to lead the category with running specific tights. Next-to-skin comfort is a distinct advantage of tights. Their 4-way stretch fabrics offer superior mobility and moisture management. Add reflective elements and you get a running wear for all conditions.
Loose-fit styles also serve you well for running and all-around active use. Breathable fabric and mesh panels keep them comfortable and functional. These running pants offer full mobility and range of motion with stretch fabrics. Ibex even makes a women's loose tight with a wool, nylon and Lycra® blend designed for all natural warmth and comfort. Loose fitting styles also make great post workout wear - throw them on after your workout to run errands or to enjoy the sunset. Loose styles also offer more pockets for the essentials and added warmth when worn over shorts or tights before or after your workout.
Regardless of your preferred style, running pants and tights offer added warmth and UPF protection. Perform at your best by keeping your muscles warm and ready for action with the style of your choice.
We're Available:
Mon-Fri: 7:30am-4:00pm PST
Sat-Sun: CLOSED


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On the 60th anniversary of Joseph Stalin's death last week, the Associated Press reported that admirers of the Soviet dictator, one of history's bloodiest tyrants, were flocking to the Kremlin to venerate him as a great leader despite his ghastly record of repression. With polls showing a rise in Russians' admiration and nostalgia for Stalin, observed the Associated Press, "experts and politicians puzzled and despaired over his enduring popularity."
That some Russians express approval for a despot who has been dead since 1953 is distressing, though perhaps not surprising given the ongoing campaign to burnish Stalin's image by Russia's autocratic president, Vladimir Putin. But even more of a reason for puzzlement and despair is the enthusiastic applause for Stalin by influential American liberals when he was at the height of his bloody reign — and the willingness of similar propagandists, naifs, and true believers today to sing the praises of other thugs and dictators.


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text: Five-year-old Ricardo is recovering. He has a lot of stitches after being bitten by a really big dog. We're told a neighbor's Rottweiler had its way with Ricardo, and it's a Monday this sweetie pie and his parents won't forget."As my son was leaving out of the yard to get in his grandmother's truck, the dog grabbed my son's leg and was shaking his leg to where he fell and hit the ground. The dog [dragged] my son to the other dogs and had my son's face in his mouth and was shaking his face," said Lucinda Gavin. "All I'm hearing is my son [saying] 'Mommy, help me. Please, mommy, get him off me. Mommy, get him off me. Help me,'" she added. "Blood just rushing everywhere, I instantly paniked."As soon as he heard what happened, DePaul Simmons rushed to the scene in southwest Detroit."My wife was in the middle of the street hysterical. He was sitting in the back of the truck. He just started screaming, "Daddy," and I made them take him to the hospital, and from there I took over. [The] police never came," he said."If it wasn't for me and his grandmother and his father, my son, God knows, would not be here breathing right now," Gavin said.It was not over then, and it's still not over now because Simmons said he waited several hours to see what was going to be done with the dog that did this to his autistic son. When he didn't see the law, he took the law into his own hands."I beat him with an axe," Simmons said, and hit the dog with his car, killing it in its own yard. There were witnesses, and he didn't care."People [are] getting attacked by dogs every day, and to just let the dog still live and roam around to do it to another person, the next person might die," Simmons said.Someone who watched him must have called the Michigan Humane Society. They showed up and left a card on his door."They [were] looking for me because they [were] going to arrest me for killing a dog and nobody showed up to save my son," Simmons said.Detroit Police are also investigating this father's fury."If they wanted some justice, they would have pulled up, they would've shot the dog [themselves]. I wouldn't have had to make it there first and do what I had to do," Simmons said."Any real parent would've done the same thing that he did. Nobody else took the justice to take care of it, so he took it, and I love him to death for it," Gavin said."For them to be looking for me and not looking for the owner of this dog, and they know who it is, it's unjust. If they want to take me to jail, take me to jail, but justice will be served on behalf of my son. I promise you that," Simmons said.Dad told us over and over that he did not see police officers or an ambulance, but I was told they both came within 24 minutes of the 911 call.A warrant has not been signed.


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By Andrea IsomFOX 2 News
DETROIT (WJBK) -- Michigan's economic development arm is being criticized for buying a newspaper ad touting the state's new right-to-work law with the "Pure Michigan" tourism logo.In the full-page ad in Tuesday's Wall Street Journal, the Michigan Economic Development Corp. said the law has Michigan poised to be a preferred place to do business. Pure Michigan is mentioned in ad, and the logo also is shown.Critics say the state's popular tourism campaign shouldn't be tied to the contentious law prohibiting requirements that workers pay union dues or fees. "It's Snyder trying to cover up what he did in a lame duck session," said Brad Manely from the ASCFME. "Passing legislation without the voter's input."Liberal advocacy group Progress Michigan said it's an inappropriate and partisan misuse of taxpayers' money.The law takes effect in late March. It's expected to face legal challenges from labor unions.- The Associated Press contributed to this report
WTXF-TV330 Market StreetPhiladelphia, PA 19106-2796Phone: (215) 925-2929Fax: (215) 982-5494