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commandlinefu.com is the place to record those command-line gems that you return to again and again.
Delete that bloated snippets file you've been using and share your personal repository with the world. That way others can gain from your CLI wisdom and you from theirs too. All commands can be commented on, discussed and voted up or down.
If you have a new feature suggestion or find a bug, please get in touch via http://commandlinefu.uservoice.com/
You can sign-in using OpenID credentials, or register a traditional username and password.
First-time OpenID users will be automatically assigned a username which can be changed after signing in.
Every new command is wrapped in a tweet and posted to Twitter. Following the stream is a great way of staying abreast of the latest commands. For the more discerning, there are Twitter accounts for commands that get a minimum of 3 and 10 votes - that way only the great commands get tweeted.
» http://twitter.com/commandlinefu
» http://twitter.com/commandlinefu3
» http://twitter.com/commandlinefu10
Use your favourite RSS aggregator to stay in touch with the latest commands. There are feeds mirroring the 3 Twitter streams as well as for virtually every other subset (users, tags, functions,…):
Subscribe to the feed for:
Site by David Winterbottom (user root).
An alias i made for myself to play music in a faster way.
Works great when you have Guake / Tilda installed (Console that drops down like in the game QUAKE)
I put this in my bash_alias file (I'm on ubuntu, the bash_alias file does autostart with the right config) but it works putting it in bashrc too. Or anything that autostarts when the console is opened.
Needs Mplayer and music files to work. With out music theres nothing to play!
Oh, and also, without modification, this alias will try to play stuff from your ~/Music folder! (case sensitive). Make sure that folder exists and has music OR edit this alias to fit your needs.
For use in scripts this command is very usefull
After typing cd directory [enter] ls [enter] so many times, I figured I'd try to make it into a function. I was surprised how smoothly I was able to integrate it into my work on the command line.
Just use cdls as you would cd. It will automatically list the directory contents after you cd into the directory. To make the command always available, add it to your .bashrc file.
Not quite monumental, but still pretty convenient.
Add z to the flags to enable compression.
Often, the very next command after the cd command is 'ls', so why not combine them?. Tested on a Red Hat derivative and Mac OS X Leopard
Update: changed ${1:-$HOME} to "${@:-$HOME}" to accomodate directories with spaces in the names
Add the functions to the .bashrc to make it work
Example: First go to the iso file directory and type:
user@box:~$ miso file.iso
It will put you into a temporary mounting point directory (ISO_CD) and will show the files
You can umount the iso file whatever the directory you are
user@box:~/ISO_CD$ uiso
It wil umount the iso file and remove the temporary directory in your home
If you use symlinks a lot, especially nested symlinks, this puts you back on the absolute path to command-line-fu-nirvana. (Note the backticks around pwd).
!$ recalls the last argument of the previous command. This is very useful when you have to operate several operations on the same file for example.
only works for freeBSD where ports are installed in /usr/ports
credit to http://wiki.freebsd.org/PortsTasks
uses tar to dump files from /orignl/path to /dst/dir. i find tar's out more readable than cp, and it doesn't mess with modified dates.
cd - would return to the previous directory of your cd command. NB: previous dir is always stored in $OLDPWD variable.
Useful to quickly get back to the Windows root directory of the current drive from a sub-directory within that drive.
Works also without space between 'cd' and backslash: 'cd\' or 'cd \' have the same effect
In the Windows cmd.exe window, you can change the directory using cd, but if you need to go to a directory on another drive, you need to type in the drive letter and colon first (e.g. d:). With the /d on cd, you don't need this intermediate step.
cd /?
Tested on Windows XP
If you are in /begin/path/with/XX/pattern
cd XX YY
will change your current directory to
in ZSH
Please see sample output.
Copy data to the destination using commands such as cpio (recommended), tar, rsync, ufsdump, or ufsrestore.
Let the source directory be /source, and let the destination directory be /destination.
# cd /source
# cd ..
# find ./source -depth -print | cpio -cvo> /destination/source_data.cpio
# cd /destination
# cpio -icvmdI ./source_data.cpio
# rm -rf ./source_data.cpio


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Bayview Street Cardigan
Last fall, I began sketching a collection of works inspired by the landscapes – seascapes, rather – of my childhood on Cape Cod. About ten years ago, as a new knitter, I made a simple, raglan pullover for my grandmother. She would never buy herself a fancy sweater, and I thought it would be nice to make one that fit her very petite, barely 5′ self. For it to be worn at all, it needed to be something she could grab on her way out the door to wear down the street to the beach, where she liked to watch the ferries coming and going into and out of Hyannis Harbor. She loved it, partly because, for once, nothing needed to be altered: it fit perfectly. What made that sweater so perfect? It was simple, easy, it fit, it went with everything, and she could wear it anywhere. My other designs may be knitterly (i.e., with knitting interest like steeks, cables, and lots of color changes), but they are not articles I would wear anytime, anywhere. Last fall, I decided to design a cardigan that would be both knitterly and appropriate to wear every day.
Bayview Street Cardigan is the product of my efforts. I decided to name it after Bayview Street Beach, where I spent a good deal of my childhood. Down the street from my grandparents' home, it may very well have been my first beach. As you can see, Beatrix has spent some time there too.
For this particular project, the yarn holds just as much appeal as the design. I wanted something soft, but I rarely use 100% merino yarns because they often fall apart so much more quickly than woolly wools. I selected Frog Tree Meriboo, which is 70% merino and 30% bamboo, in hopes that the strength of the bamboo would add some durability to the garment. The knitted fabric is both soft and strong as well as a little shimmery. One of the funniest parts of this design story involves the yarn. When chose Meriboo, I noticed Frog Tree was based on Cape Cod. When I spoke to Trish, one of the owners, she explained they were located only a few miles from this beach. Small world, no? In any case, Trish sent me a lovely card and a good deal of yarn to complete this project, for which I am very grateful.
I finished the pattern just after Odysseus was born, creating another problem: how to photograph it? Fortunately, my dear friend Ingrid came to the rescue with the perfect measurements to model the work. I thank her for the impeccable styling, modeling, and photography! Don't they look great? I think it's funny that although I did not tell Ingrid the story of the cardigan, she styled her photos at the beach.
As for the sweater details, the cardigan features tubular cast-ons at the hem and cuffs, tubular cast-offs at the neck and button bands, tapered sleeves, tailored waist shaping, and a very simple, 5-stitch lace repeat over the body. The cardigan and sleeves are each knitted in the round in one piece to the armholes, then worked flat. The only seaming required is to sew the sleeve caps into the armholes. I debated about adding a belt, but decided against it in the end because it would have required too much dull knitting for not enough use.
I am particularly happy with how the tubular edges look. Although it is a terribly fiddly endeavor, the finished product is worth the effort. Plus, it yields a nice and stretchy edge.
The buttons caused me no end of grief, as every kind I tried either looked or photographed poorly. In the end, I bought a fat quarter of coordinating fabric and made fabric-covered buttons myself. My grandmother would definitely approve of that, as she was quite the seamstress in her day! All in all, I will call this project a success. I hope you'll think so too.
For more information about the pattern, please see the Bayview Street Cardigan page. The pattern is also available on Ravelry for $6.50.
**Photo/model credit: Ingrid Deon**
15 comments so far
This is gorgeous! Another lovely pattern from you, thanks!
I love it. It looks like a great design, and the coincidences of locale are cool!
It's so pretty! And something that my grandmother, who lived in Centerville, would have loved. :-)
Such a beautiful cardigan and a lovely story!
Aw, Ingrid is my dear friend too and she makes the cardigan even prettier!
It's stunning as always, Elinor!
What a weird coincidence about the beach! I had NO IDEA! I love the story behind the cardigan — so sweet!
I LOVE it! As a Cape Cod resident, I can personally attest to this sweater's appeal. :)
This is a beautiful cardigan! Love the buttons you came up with! Congratulations!
It's beautiful! And the yarn looks (from the pictures at least) to be a great choice for the pattern. I love the little bit of bamboo sheen with the lace.
[...] become obsessed with the Bayview Street cardigan pattern from Elinor at Exercise Before Knitting. I've been doing so much gift knitting lately, [...]
A lovely design & it looks great.
lovely cardi!
Love that!
Tre bela cardigan!

subset: commoncrawl


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Download the WQOW Weather App for your Android, iPhone, iPad and iPod Touch.
Want weather on the go?
Get the new WQOW Weather app on your phone or tablet!
The WQOW Weather app features interactive radar, hourly and daily forecasts, current and future temperatures, weather alerts, video forecasts from the Hometown Weather Team and top headlines from WQOW.com. You can even submit your own photos and videos of how the storm's affecting your town!
WQOW Weather App for Android (cell phones or tablets)
WQOW Weather App for iPhone and iPod Touch
WQOW Weather App for iPad
At this time, the WQOW Weather app only works for Android and Apple systems.
Frequently asked questions:
Q. It keeps showing the weather for Eau Claire, but I don't live in Eau Claire. How do I show my city?
A. The default city for the app is Eau Claire, but you can change this easily. Just make sure you delete Eau Claire.
1) Click the button that looks like a house (next to the (i) button on the top right hand corner).2) Click the plus symbol on the top left hand corner to add another location by city, zip code, coordinates or airport code.3) Once you've found your location and are back to the "Locations" screen, click the gray star next to your location to change it from gray to gold. Then click the pencil icon next to Eau Claire and delete Eau Claire.
Q. I'm getting too many alerts/not enough alerts. How do I change these?
A. Click on the (i) button in the top right hand corner, then click the "Other" tab under "Settings." You can find all of your options under "Notifications," including the types of alerts you want ("Critical" or "All") and how you want to be alerted "LED lights," "Sounds" and/or "Vibration." You can also choose to not get weather alerts in your status bar.
Q. How do I submit my photos or videos?
A. At the very bottom, scroll to the right until you see a "Submit" tab. Clicking there will take you to a screen where you can either submit a previously-shot photo or video from your phone's gallery, or take a new photo or video immediately and submit it automatically. Submitted photos and videos show up in WQOW's NEWSFROMU and may be used online or on air.
Q. How can I get the app to not run in the background?
A. The WQOW Weather app will automatically provide the current temperature and notify you when a storm alert has been issued. If you'd rather not have this feature running in the background, complete the following steps:
1) Go to the app and click on the (i) on the top right hand corner.2) Click the "Other" tab under "Settings."3) Uncheck "Status bar notifications." Click "Done."


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David Yurman uses color fearlessly, combining gemstones in unconventional ways to create truly distinctive and captivating palettes. "Fashion has color moments," he says, "but the reality for me is it's not about trends. There are moments when you want something soft and muted, and moments when you want something deep and rich. I like the idea of mixing colors that you don't often see together, that might feel a bit odd, yet the result is refreshing."
This motif takes its minimalist cue from the self-aligning ball bearing, which is used in modern machinery to ensure precision. Its deceptively simple design is captured in this collection, which also features subtle sculpted Cable accents.


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Getting The Most Out of Your Pharmacy Visit
Medical Author: Omudhome Ogbru, Pharm.D.
Although most people have visited a pharmacy, very few people are aware of all of the services that pharmacists can provide. What goes on behind the pharmacy's glass partition? Why does it take so long to get a prescription filled? This article discusses the role of the community pharmacist in providing healthcare and provides advice on getting the most out of each visit to the pharmacy.
The community pharmacist is primarily responsible for accurately filling prescriptions and ensuring that patients have enough information to effectively and safely use medications. Before a patient leaves the pharmacy with a medication, the pharmacist must be certain that the patient has the right medication, correct dose, and directions for use.
The pharmacist also provides information about how the drug works and its potential side effects and ensures that there are no contraindications to the medication (medical reasons for a patient to avoid the medication) and no potentially harmful interactions with other drugs the patient may take, foods the patient may eat, or diseases that the patient may have. The pharmacist does this by transcribing the doctor's prescription accurately, interviewing and counseling the patient, and using his or her knowledge of the condition that is being treated and the effects of the prescribed drug.
Since the pharmacist is usually the last healthcare professional to have contact with patients before they receive their medications, they are the final step in a system of checks and balances designed to ensure that medications are used safely and effectively. If the pharmacist believes that there is a problem with the prescription, he or she calls the prescribing doctor in order to review the prescription. For example, the wrong drug or dose may have been prescribed or the pharmacist may determine that there is a safer or more effective medication than the one that has been prescribed.
Apart from ensuring that patients leave the pharmacy with the right medication, pharmacists also provide drug information to healthcare professionals and the public. They assist physicians in appropriate drug selection, advise patients on appropriate over-the-counter remedies, and counsel the public on preventative therapies. Some community pharmacists offer monitoring services for cholesterol, blood pressure, and blood glucose. They also may run smoking cessation and weight-loss programs.
This description of what pharmacists do seems straightforward. So why does it take so long to fill a prescription? There are a number of reasons.
Now that I have shed some light on what pharmacists do, here are some tips on how to save time and get the most out of your pharmacy visit.


text:
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I'm a fan of The Blazers getting my heart racing and my blood pumping! RIP CITY!!!
This photo: Batum Jumper Vs LA /
put this photo on your page
© 2004-2011 by the Portland Trail Blazers. All Rights Reserved.
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Posted by Web Staff - email | Facebook | Twitter
UPDATE: CLEVELAND, OH (WOIO) - New details in the case of the Cleveland Strangler.
A pretrial hearing was held Wednesday afternoon for accused serial killer Anthony Sowell.
Sowell is asking for more money to pay a paralegal and to review more than 2,000 hours of surveillance tapes frpm cameras in the neighborhood, one of which was on the corner.
The judge did not issue a ruling on Wednesday. No word on when he may do so.
Sowell is facing death row for allegedly killing eleven women attacking at least four others. The bodies were found in and around his Imperial Avenue home last November.
He's due back in court on November 10th.
Copyright 2010 WOIO. All rights reserved.
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EEO Report
Closed Captioning


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User Tip: If you're unsure of your vehicle type, you may skip the machine type selection box.
Select type, make, model and year above
"Customer service is priority #1 at Rocky Mountain ATV/MC. We value our customers and strive to be the best shopping experience- when you buy from us, you are buying lifetime service."
-Dan Thomas, CEO and Founder
We take pride in offering no hassle returns. In the event of a return, please call, email or chat with us to receive a solution to the problem. For apparel that doesn't fit quite right, Click here to see our Fit Guaranteed Program.
We will stand behind all products we sell with regards to manufacturing defects in workmanship and material. Most products are limited to the manufacturer's warranty. However, we will do everything in our power to take care of the problem.
Live chat: Click here
(Leave email if after hours)
Call us: 1 800 336-5437
7am-7pm Mon-Fri 8am-4pm Sat (Mountain Standard Time)
Each review submitted enters you into a $100 gift card monthly drawing, and a $500 gift card quarterly drawing!
Comments On Jul 29, 2014:excellent fit and finish, seals are tight, finished assembly works great
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Comments On May 28, 2014:Seem to be of good quality. I pop the seals out and pack some waterproof grease in them just for extra insurance.
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Comments On Apr 26, 2014:good price, quality product
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Comments On Jun 05, 2013:I haven't put any time on this kit yet, but the parts looked to be of decent quality and everything went together as it should. I liked the caps that were used to hold the needle bearings in the races during shipping as they also helped keep the bearings clean during installation. If kept greased I can't see why these won't work fine.
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Join the Conversation—Share the Experience inNASP Communities!
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NASP membership helps keep me up to date on everything related to the field from research to apps to books!Tina Guerra Miller, New Jersey
Get students talking about mental health, now through October 31 with the Text, Talk Act program
Learn about K-12 online learning and the training needs of school psychologists in this informative podcast
Share this handout on response to intervention (pdf) with students' parents in your district
Get counseling guidance specifically for school psychologists
Best Practice in Crisis Prevention
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From Michael Phelps winning eight gold medals at the 2008 Beijing Olympics to Nadia Comăneci receiving the first perfect 10 in 1976, there have been several unforgettable moments in Olympic history.
As hundreds of world-class athletes prepare to compete in the 2012 Summer Olympic Games beginning July 27, Patch is celebrating the start of the games by posting Olympic trivia questions all this week.
Post your answers in the comment section, and we'll post the correct answers in the comments by 4 p.m. today.
- Which author of the seminal book on baby and child care was also a gold medalist.
- Dr. Benjamin Spock
- Dr. Michael Cohen
- C. R. Partridge
- Jane Mattes
2. How long is the route for the marathon event in the 2012 Olympics?
- 8 miles
- 11.2 miles
- 26.3 miles
- 40.6 miles
3. Who lit the torch to start the Games in Atlanta?
- Wayne Gretzky
- Cathy Freeman
- Muhammad Ali
- Ken Henry
4. What is the name of the mascot of the 2012 Games?
- Misha
- Sam
- Izzy
- Wenlock
Looking for a way to celebrate the Olympics locally? You can find local events for Olympic Fun Day on July 28 on the Let's Move website, which has a page about how to set up your own local Olympics.
Also check out our Directory and Events Calendar for listings of places where you can learn and participate in Olympic sports ranging from basketball to karate, gymnastics, swimming and more.


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Cabinet approves Annual Disarmament Report
On 29 February, the Federal Cabinet approved the Annual Disarmament Report for 2011. It comprehensively presents the main developments as well as the policies of the Federal Government in the fields of disarmament, arms control, and prevention of the spread of weapons of mass destruction and means of delivery.
Germany supported the inspection of chemical weapons depots in Libya.
© BMVg
Together, disarmament, arms control, and non‑proliferation form a pillar of the Federal Government's foreign and security policy. In 2011, it was above all Germany's efforts in the areas of post-conflict scenarios and preventative crisis policy that were in demand. Through concrete projects in Libya, Germany helped counter the dangers arising from unsecured weapons.
The threats to the global non‑proliferation regime and regional stability posed by countries such as Iran and North Korea remain serious. Syria is also a challenge to the international community's efforts to ensure regional stability.
For a world free from nuclear weapons
The Federal Government also supports the vision of a world free from nuclear weapons. It welcomes the New START Treaty between the United States and Russia, which came into force in February 2011. Together with its partners in the Non‑Proliferation and Disarmament Initiative (NPDI), Germany advocates quickly starting negotiations on a production ban on fissile material for nuclear weapons and implementation of the Comprehensive Nuclear-Test-Ban Treaty.
In a mine victim centre in Cambodia
© picture-alliance/ZB
Conventional arms are also a threat to security
The Federal Government is also emphatically committed to effective conventional arms control in Europe. Here it is mostly a question of ensuring verifiable transparency of arsenals in this field. Another important topic in 2011 was making the scope of the conventions on cluster munitions and land mines universal. The Federal Government has agreed to increase funding for humanitarian mine clearance and victim care for 2012.
The German Bundestag has called on the Federal Government to present an annual Report on Progress on Arms Control, Disarmament and Non‑Proliferation and the Development of the Capabilities of the Armed Forces by 30 April of the year following the period in question. The year 2011 is covered in the report just published, the 29th of its kind. In addition to the Federal Foreign Office, the Federal Ministry of Defence, the Federal Ministry of Economics and Technology, as well as the Federal Ministry for Economic Cooperation and Development all contributed to the report.
Last updated 29.02.2012


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John Piper Teaches Through The Book Desiring God - Chapter ten - Ministry Videos
Press the button below if you liked this video! Thank you! =D
237 views
Posted By waterbrookmultnomah 2011-03-28T17:27:33
Satisfaction...Happiness...Joy. According to John Piper, the pursuit of pleasure in God is not only permissible, it's essential.
Desiring God is a paradigm-shattering work that dramatically alters common perspectives on relating to God. Piper reveals that there really is no need to choose between duty and delight in the Christian life. In fact, for the follower of Jesus, delight is the duty as Christ is most magnified in His people when they are most satisfied in Him.
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- Pastor
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text:
Search for our wines in your area
Browse our great selection of wines
Limited Production
Only 875 cases!
2012 Phantom Ranch Pinot Noir
Intense violet red color with complex aromas… Read more
We're excited
to see what
the 2013 vintage
will have in store
for us with the
fruitful harvest of
great quality grapes.
Stay tuned!
© 2014 Laird Family. All Rights Reserved.Website by designthis!


text:
Jeff Tuel threw for 285 yards and two touchdowns, as Mike Leach's Air Raid offense put on a show at Saturday's Crimson & Gray scrimmage at Joe Albi Stadium in Spokane.
The defense was credited with 9 sacks while hauling in two interceptions. The scrimmage was the Cougars' final one of the spring. It marked the second time in a row the team has traveled to Spokane to play a final scrimmage.
Washington State's season kicks off September 1 on the road against BYU.


text:
11 U.S. Code § 728 - Repealed.
prev | next
Section, Pub. L. 95–598, Nov. 6, 1978, 92 Stat. 2611; Pub. L. 98–353, title III, § 481,July 10, 1984, 98 Stat. 382; Pub. L. 99–554, title II, § 257(t),Oct. 27, 1986, 100 Stat. 3116, related to special tax provisions.
Effective Date of Repeal
Repeal effective 180 days after Apr. 20, 2005, and not applicable with respect to cases commenced under this title before such effective date, except as otherwise provided, see section 1501 ofPub. L. 109–8, set out as an Effective Date of 2005 Amendment note under section 101 of this title.
The table below lists the classification updates, since Jan. 3, 2012, for this section. Updates to a broader range of sections may be found at the update page for containing chapter, title, etc.
The most recent Classification Table update that we have noticed was Tuesday, August 13, 2013
An empty table indicates that we see no relevant changes listed in the classification tables. If you suspect that our system may be missing something, please double-check with the Office of the Law Revision Counsel.
|Description of Change
|Session Year
|Public Law
|Statutes at Large
LII has no control over and does not endorse any external Internet site that contains links to or references LII.


text:
Eclipse shower enclosures are a dramatic design statement waiting to revolutionise your bathroom. Striking exposed rollers provide a smooth shower door sliding motion. Low profile trays and ultra low level trays arent suitable for installation on all floor types. Installation on a wooden floor is fine as you can inset the waste and pipe into the void between the joists. If you are fitting on concrete floor or wish to run the waste over the wooden floor, you will need to use the easy plumb kit.
*Free delivery over £50 refers to home delivery orders placed on diy.com only. Charges refer to the value of goods being delivered and excludes delivery from stores or services. Excludes bulk delivery.
B&Q accepts the above cards and also offers a range of in-store financial services. Learn more
Buy online, return in store. Terms and conditions apply
Have a question or a problem, chat to our support team now.contact B&Q
© B&Q 2014 - Terms & Conditions


text:
I apologize in advance for this being a cross-post with my PIH saga post that is much longer. I thought that more people might see/respond to this than a question buried in my original post.
I got on some BP meds last night after my BP's had been staying around the 160s over 100-110s. I don't know the dose but he said he was starting it at a low dose. After an hour, my BP dropped from 165/100 to 132 over 72. I was not feeling good. Everything was shaking/jittery, even my lips! They made me drink juice and milk and eat peanut butter and crackers and that sort of helped.
Are you supposed to eat with this stuff when you take it? I asked the nurses but they said no. Does my body just have to get used to it?
But, I slept until 6 am when they checked me again and it was up again to 160 something over 105. I am due for another dose of BP medicine at 8 am. I know I just started it...does it eventually work for the full 12 hrs?
Dr said it would take a day or two to really start working...is that what he means? That it will eventually cover me for 12 hrs? Thanks for your advice and insight.


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Lateral Files feature drawer extension restraint; mechanical interlock inhibits the extension of more than one drawer at a time. Offers four adjustable leveling glides, baked enamel finish over rust-inhibiting phosphate pretreatment. Two adjustable hangrails per drawer for side-to-side filing. Three-part, telescoping, slide suspension operates on 40 steel ball bearings per slide. Equipped with HON "One Key" interchangeable core removable locks. Keyed alike cores must be ordered separately. Reinforced case construction. Full-width integral drawer pulls. Magnetic labels standard (one per drawer). Meets or exceeds ANSI/BIFMA and ISTA performance standards.
Shipping Weight: 163 lbs.


text:
Bench - Gray - 36"
Item #: 869203 |Model #: SPPB36-G | (2) |
This versatile bench is stylish, lightweight and durable.
This versatile bench is great for the deck, pool area, spa area, in your garden, on the front porch, along a walking path and for your business. It is lightweight, and durable, made of high-density polyethylene plastic with UV inhibitors. It will retain its color and is maintenance free. With a snap-together design, it requires no tools to assemble.
Assembled Country
Assembled Size
36"L x 20"H x 12"D
Component Country
Ask & Answer
Warranty Information1 year limited
There is no additional information available for this item.


text:
Texas Gov. Rick Perry has officially notified the federal government that the state will not set up an exchange to help people buy health insurance.
Perry sent a letter to Health and Human Services Commissioner Kathleen Sebelius on Thursday that Washington will have to set up the exchange instead.
The health insurance exchanges are required under the Affordable Care Act. They give people without insurance an online market place to buy health insurance that suits them. People with low incomes and special needs will get subsidized insurance when the exchanges begin operating in October 2013.
The Obama Administration gave states the option of setting up their own exchanges, partnering with the federal government or letting Washington do it.
Perry calls the health care law federal overreach.
- Obama Administration Extends State Deadline on Affordable Care Act
- Obama Admin. Partners with Health Insurers to Prevent Fraud
- Gov. Rick Perry Calls For Affordable College Rates
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Bass Guitar, Guitar, Music Performance, Music Recording, Music Theory, Songwriting
I have 15 years of musical experience studying jazz and classical composition with Grammy nominated recording artists as well as a brief stint with the University of Miami Youth Guitar Orchestra. I am currently a working performer that plays around the South Florida Area in various musical projects (Nixa) and cover bands (Franklin's Wheel). In addition to my guitar and bass playing skills, I am an experienced music producer who holds a certificate of completion as an Electronic Music Producer at the SAE Audio Engineering Institute in North Miami Beach, FL.
Currently, I am an active recording, writing, and producing musician within the South Florida area in various bands and other production projects as well as providing lessons to students throughout the South Florida area.
*** Lesson Details ***
Student's can expect a very laid back and relaxed disposition from my self as I try to focus on my student's specific goals and aspirations. The curriculum is dependent on the student's specific needs but we will always initially focus on technique, articulation, and basic music theory (depending on one's level) as to help bridge the gap between learning the technique of playing the instrument and knowing what to do with that technique. Other focal points of my lessons include: Different styles/genres of music (Rock, Jazz, Country), notational/site reading skills, and more. Once a base is set and these particular skills continued to be honed it sets the groundwork and base where they can improve upon their technique and performance skills at their own rate. Taking guitar lessons with me, we will try and cover all of these aspects of playing to ultimately to help you achieve the goal of being the guitar/bass player YOU want to be.
*** Studio Equipment ***
The In-Studio lessons take place in a separate room which has been converted into a music studio including 3 amps, several types of guitars, two basses and a computer work station. If you can not bring your own instrument you may use one of mine, but it is highly recommended that you do own your own for practice purposes.
*** Travel Equipment ***
I will bring my own guitar to lessons I travel to, and students are required to have their own instrument as I will not provide one for out of studio lessons. Thank you for understanding.
*** Specialties ***
I listen to a wide range of music and feel anyone that wants to play music should try to as well, as to establish a wide palate of inspiration where they can draw upon it and apply it to their own work in progress. In addition to my guitar and bass playing, I'm an experienced music producer who holds a certificate of completion as an Electronic Music Producer at the SAE Audio Engineering Institute in North Miami Beach, FL. Currently I am an active recording, writing, and producing musician playing guitar and bass within the South Florida area in various bands while keeping busy with other production projects and providing lessons to the south Florida area.
ACT, Algebra, Arithmetic, Basic Math, Cello, Elementary Math, English, ESL, Fiddle, Flute, Geometry, GRE, History, Language, Math, Music Performance, Music Theory, Piano, Polish, Pre Algebra, Reading, SAT, Science, Test Prep, Trigonometry, Viola, Violin
For my tutoring sessions I use skills that include goal-directedness, I teach how to organize learning in small steps and how to set them up; I always strive to motivate and engage my students to make the learning interesting and fun; I also use self-control skills to teach how to avoid distractions and I use different focusing strategies. I use positive mind set skills to teach how to use failures as a learning opportunities.
I have a Master's Degree (2012) in teaching English to speakers of other languages, and Bachelors in Music Education (2010), both from Florida Atlantic University, as well as degree in violin performance from Poland.
I studied piano in Poland for 10 years & taught both piano & violin for over 20 years. I also teach flute & cello for the past 5 years, as I studied them during my Music Education program.
I teach music for over 24 years using the traditional and Suzuki methods. I am a fan of the Essential Elements 2000 for string instruments, and the Alfred's Piano Library for piano. Alfred's piano library can be used for any age as they also have books especially made for adult learners. I also like their music flash cards.
For teaching music theory I mostly used Master Theory.
I personalize every lesson, and always set goals for my students. Most of my violin students are members of the Florida Youth Orchestra as well as Gold Coast Youth Orchestra and my piano students participate in Pompano Beach competition and the annual Piano Guild auditions.
I teach any age and any level, and always stress that learning a new instrument is very similar to learning a new language, it needs a lot of patience, persistence and repetitions. My lessons are customized to my students needs, and are work in progress as they needs may change over time. I always remind my students that music can give them instant gratification when they learn to play favorite songs.
I always encourage my students to tell me about their music preferences, so I can incorporate them in their music lessons.
*** Lesson Details ***
All my tutoring sessions include reviews of previously learned material and if possible the use of technology. I use students books but often bring extra study materials if necessary.
All my lessons include: technique: I like to use the Finger Power for piano students and Essential Elements for my string students, and scales for both.
music theory: I use Master Theory or other books such as Hal Leonard's Piano Note spellers & Piano Music Theory books for younger ages, music flash cards to support learning notes and musical terminology, and of course the fun part performance.
Besides Essential Elements 2000 for strings I also use String Tunes and Fiddle Runners to add more fun to the lessons. For piano students I use Holiday Treats book, which comes in 2 different levels: Beginner & Intermediate, so my students have a new songs for a specific holiday.
*** Studio Equipment ***
I always bring violin with me to be able to show what I teach.
*** Travel Equipment ***
The students needs to have their books and assigned material ready for tutoring. Instrumental students needs to have their music books & instrument available as well as a pencil. I always stress with my students to be organized and prepared for their lesson, this way they will be able to focus better during the lesson. I bring my violin with me. I also ask that the room where the lesson takes place to be free of any distractions, such other siblings or any other noise. The quiet environment helps in faster learning.
*** Specialties ***
I tutor most K-12 subjects and prepare students to take ACT, SAT, GRE tests.
Music genres: Classical, traditional, Suzuki, Popular, Celtic, fiddle, Blues
Classical Voice, Country Singing, Ear Training, Gospel Singing, Jazz Voice, Music Performance, Music Theory, Opera Voice, Singing, Speaking Voice, Vocal Training
My name is Nicole but you can call me Nikki! Here's a little about me and what I've accomplished.
My Background:
I have been singing since the age of four! I am a native of Miami Beach Florida. I started performing in church and school where my passion for performing were developed. Having come from such a background I was privileged with a well rounded musical tastes, from Gospel in church Classical in school, and Reggae, Pop, Rock, and R&B from her parents. In performing in contests and local shows I learned a lot about stage presence and can share that with my students as well. I earned my bachelor's in Studio Music and Jazz Voice at the University of Miami and Minored in Music Business. At UM I had the opportunity to study with critically acclaimed Jazz musicians and artists such as Kevin Mahogany, Kurt Elling and John Secada. Since earning my degree I've worked with the Florida Grand Opera in their production of Aida, also sang background vocals for Gloria Estefan and Michael Buble. I currently perform around South Florida at various hot spots with my self titled band! So those who teach can do too!
My main objective as a performer is to effectively and skillfully entertain a variety of audiences to the best of my ability using the knowledge that I have attained from my experiences as a student and as an entertainer, and in turn work for an established business in the music industry and become a successful artist.
My objective as an educator is to not only teach my students about music but allowing them to grow and flourish as performers and as musicians, with proper technique the skies the limit!
*** Lesson Details ***
My teaching style is pretty laid back and fun, it will take work and dedication on the part of my students to work on the new skills and techniques they will be learning under my direction. In the first 2 months we will focus on technique, meaning breathing exercises, vowel placements, warm ups, and execution of a song of the students choice, by the third month these exercises would have improved your vocals ability tremendously we can then work on stylizing for the particular genre your interested in singing in. Each student will have a personally tailored lesson plan to better help them in their goals to be a better singer and performer. I do prefer students in the age ranges 12 and up, only because the voice hasn't fully developed yet to do extensive vocalizing but with younger students we can focus on breathing, warming up properly and theory, which is so important at a young age and will better assist you especially when it comes to developing your ears. If you're wanting to learn to sing in different styles without losing your voice or hurting yourself I'm the teacher for you!
*** Studio Equipment ***
Keyboard in living Room: couches and chairs, parents can sit in on lesson
*** Travel Equipment ***
Keyboard should be provided by student, I will provide mic and amp
*** Specialties ***
Pop, Rock, R&B, Jazz Styles are my specialties.
Acting, Classical Voice, Finnish, German, Italian, Jazz Voice, Musical Theater, Music Performance, Music Theory, Opera Voice, Singing, Swedish, Vocal Training
I am passionate about music and singing. I have sung professionally on stages all over the world for 30 years, singing 70 roles in 10 different languages. I was the Principal Mezzo Soprano at the Finnish National Opera, a European A-house in Helsinki, Finland, (over 500 employees) for 25 years. My American Debut was at the Dorothy Chandler Pavilion in Los Angeles. My other great passion is teaching voice. It is wonderful to experience the joy that a student feels after finding his/her voice and starting to improve his/her performance.
By now I've worked as a voice teacher for 15 years, well familiar with both European and American voices.
I have a Master's degree in Music, including performance and teaching. I have had additional education in Complete Vocal Technique, which familiarizes me with Pop-, rock,- jazz-, and country singing techniques.My students include both beginners and professionals. I can teach you both to sing like an opera diva, and to belt and sound like a pop diva. For me, the basics are important. I want you to learn proper breathing, support, relaxation and interpretation. With a good foundation, you have a technique that lasts a lifetime.
I am very serious about what I do, and I expect my students to be equally serious in their work. With all this said, expect to learn a lot with me, but also expect to have lots of fun doing it.
You will have better singing for a better life!
Acoustic Guitar, ACT Science, Anatomy, AP Biology, Arabic, Bible Studies, Biochemistry, Biology, Blues Guitar, Cell Biology, English, Genetics, Guitar, Microbiology, Microsoft Office, Molecular Biology, Nutrition, Physiology, Science, Soccer, Sports Nutrition, Squash, Study Skills, Swimming
An American Board Certified Dentist, Head and Neck surgical resident.
I am an overseas trained Dentist and Surgeon. After I graduated from Dental School I started residency specializing in Oral and Maxillofacial Surgery. Now I just cleared my Board Exams in the US to become a licensed specialist here.
I have been giving private lessons since I was in dental school. I have experience for more than 7 years now with a wealth of resources and experiences at my disposal. I have been involved in teaching Immunology, Pathology, and Human Anatomy to undergraduates and capable of teaching both clinical & basic medical sciences in both English and Arabic.
Teaching has always been a passion of mine, I have taught Biology and Arabic to people of all ages, and I have efficient teaching methods and mnemonics to simplify difficult topics so they can be better understood.
I have helped teenagers prepare for their GCSE and A-Level exams as I have graduated with an IGCSE diploma from high school. I have worked with high ability students to ensure A grades, and borderline students to ensure a good pass. I firmly believe that with the right guidance and the right effort, any student can achieve the grade they need to succeed.
Currently living in Plantation, but I am flexible with traveling.
Accent Reduction, Acoustic Guitar, ACT, ACT English, Acting, ACT Math, ACT Reading, ACT Science, ACT Test Prep, Algebra, Algebra 1, Algebra 2, Anatomy, Anatomy and Physiology, AP Biology, AP English, AP English Literature, AP Exam Prep, Arabic, Arithmetic, Arrangement and Composition, Art History, Audition Prep, Baking, Baseball, Basic Math, Basketball, Biochemistry, Biology, Bowling, Business, Cell Biology, Chemistry, Child Acting, College Admissions, Composition, Country Singing, Creative Writing, Cross Country, Curling, Drawing, DSLR Video, Earth Science, Ear Training, Economics, Elementary Math, English, English Literature, Essay Writing, Figure Skating, Film Acting, Film and TV Acting, Filmmaking, Film Production, Film Studies, Fishing, Fitness, Football, GED Test Prep, Genetics, Geography, Grammar, GRE, Guitar, Hula Hoop, Humanities, Knife Skills, Language, Life Coaching, Linear Algebra, Literature, Makeup, Math, Meditation, Microbiology, Microeconomics, Microsoft Excel, Microsoft Office, Microsoft PowerPoint, Microsoft Windows, Microsoft Word, Modeling, Molecular Biology, Music Performance, Music Recording, Music Theory, Organic Chemistry, Paper Crafts, Pasta Making, Philosophy, Phonics, Photography, Physical and Earth Sciences, Physical Science, Physics, Physiology, Poetry, Pottery, Pre Algebra, Psychology, Public Speaking, Reading, Religious Studies, Rollerskating, Running, SAT, Science, Scrapbooking, Screenwriting, Shot Put, Singing, Skateboarding, Soccer, Social Sciences, Social Studies, Sociology, Softball, Songwriting, Speaking Voice, Speech, Spelling, Stage Performance, Stretching, Study Skills, Surfing, Swimming, Test Prep, Theater Acting, Theater Acting, Track and Field, Video Production, Vocabulary, Vocal Training, Voice Acting, Wakeboarding, Writing
I graduated from Nova Southeastern University in Ft. Lauderdale, FL.
I have a Master's Degree (2013) in Education teaching various subjects and Masters in Biology (2013), both from Nova Southeastern University.
I teach various subjects for over 6 years using the traditional a methods.
I personalize every lesson, and always set goals for my students.
I teach any age and any level, and always stress that learning a new information needs a lot of patience, persistence and repetitions. My lessons are customized to my students needs, and are work in progress as they needs may change over time. I always encourage my students to tell me about their preferences, so I can incorporate them in their lessons.
*** Travel Equipment ***
The students needs to have their books & materials available as well as a pencil. I always stress with my students to be organized and prepared for their lesson, this way they will be able to focus better during the lesson. I also ask that the room where the lesson takes place to be free of any distractions, such other siblings or any other noise. The quiet environment helps in faster learning.
*** Lesson Details ***
30 minute lesson - Typically do 10 to 12 minutes of warm-up and the rest of the time is devoted to practical application of technique to your songs, as well as, performance aspects. I also offer hour lessons.
*** Specialties ***
Types of Style:
Musical Theater
Heavy Metal
Science-based courses
Types of Instruction Available:
Individual Private Study
Group Study
TakeLessons is the nation's leading private lessons provider, offering customized one-on-one lessons in hundreds of subjects in over 2,800 U.S. cities, including Hollywood and surrounding areas.
Whether you are a beginner, intermediate, or experienced musician, you can benefit from working with a TakeLessons Instructor in Hollywood to make your dreams a reality. Choose from a variety of music lessons taught in the Hollywood area, including guitar lessons, voice lessons, drum lessons, piano lessons, violin lessons and many more! Explore our Hollywood teacher profiles to compare each teacher's teaching style, background, student feedback, hourly availability, and more.
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Get started with music lessons in Hollywood today! TakeLessons student counselors are standing by and ready to help; simply give us a call at 800-252-1508. You also have the option of selecting your teacher and signing up for private classes online. Get ready to learn, grow, challenge yourself, and open your life to the advantages of ongoing education through lessons.
"Steven is very professional and extremely helpful. He always has a smile on and is serious about helping you phrase the music. I would highly recommend him to anyone."
"It's been really exciting so far! Jordan has been so helpful, so knowledgeable. I could not have found a better instructor and I'm getting better and better every day."
"My daughter's wedding was weeks away and I had never been able to dance a step. With Jenny's help, I came further than ever before in such short time in any subject."


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The days of having to finish your call before heading through the turnstile or down on to the platform may be slowly coming to an end.
The MTA and Transit Wireless, the company that owns and operates the city's wireless subway service, says cell phone and Wi-Fi wiring is complete in 36 stations on the west side including Times Square, Columbus Circle and Lincoln Center. You'll be able to make and take calls, but only if you have AT&T, T-Mobile and Verizon. Transit Wireless still needs to work out contracts with the other carriers.
We found service was online in the Times Square station a couple flights down on the 7 train platform. One woman who has T-Mobile was able to get a full signal.
While for some people the subway has been the last bastion of solitude from the 21st Century wireless world, many agree some service is better than none at all.
The MTA and Transit Wireless plan to hook up some Midtown and Queens stations in December. Stations in the Bronx, Harlem and Upper East Side will follow next year.
All 277 subway stations should be wireless by April 2017, according to Transit Wireless. Service will not be available in the tunnels.
Keep in mind that NYPD has warned riders about thieves going after cell phones and iPads, so keep an eye out.
One final point, when you take or make a call, just remember to use your inside voice.
KSAZ-TV & KUTP511 W. Adams St.Phoenix, AZ 85003Phone: (602) 257-1234Fax: (602) 262-0177


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What could be more thrilling than exploring a cave 180 ft. below the Earth's surface? Spending the morning with sea lions at SeaWorld San Antonio? Screaming at the top of your lungs 100 feet above the ground at Six Flags Fiesta Texas? These are special adventures your child will be talking about for years to come... See ideas


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Slide 1
Normal Cell Communication
Crucial to all normal cell growth is a communication network that functions properly. This network is an intricate collection of pathways built with interactive proteins. Along these pathways, precise protein-to-protein signaling enables a very carefully guarded regulation of growth. Here are some examples of cellular pathways.
Slide 2
Cancer: A Communication Failure
The genetic changes involved in cancer result in altered proteins that disrupt the cell's communication network. In cancer, altered proteins along many different pathways cause signals to be garbled, intercepted, amplified, or misdirected. These changes hijack what was once normal communication and use it to achieve uncontrolled tumor growth. Here are some examples of how cancer disrupts normal cellular pathways.
Slide 3
Detecting the Troublemakers
The challenge for cancer detection and diagnosis is to locate the renegade genes and proteins--the deranged, defective, and dominating molecules--that hijack communication in once-normal cells. This requires opening the cell and analyzing the biomolecules inside. The earlier this detection and diagnosis can occur, the better.
Slide 4
Molecular Diagnostics
Before molecular diagnostics, clinicians categorized cancer cells according to their pathology, that is, according to their appearance under a microscope.
Borrowing from two new disciplines, genomics (gee-no-micks) and proteomics (proh-tee-oh-mics), molecular diagnostics categorizes cancer using technology such as mass spectrometry and gene chips. Genomics is the study of all the genes in a cell or organism, while proteomics is the study of all the proteins. Molecular diagnostics determines how these genes and proteins are interacting in a cell. It focuses upon patterns--gene and protein activity patterns--in different types of cancerous or precancerous cells. Molecular diagnostics uncovers these sets of changes and captures this information as expression patterns. Also called "molecular signatures," these expression patterns are improving the clinicians' ability to diagnose cancer. Soon all cancers may be diagnosed this way.
Slide 5
Gene Expression Patterns
A major emphasis in molecular diagnostics is placed upon the expression patterns of genes. The challenge is to find the genes active in cancer and separate them from all of the others in a cell. Fortunately, new technology makes success possible. DNA microarrays, sometimes called "gene chips," allow researchers to "see" the expression of hundreds or thousands of genes all at once.
Slide 6
Pause For a Science Lesson
To appreciate how molecular diagnostics uses DNA microarrays to measure gene activity, you first must understand a little about the human genome, genomic DNA, and messenger RNA's link to its expression. You should also remember that gene expression patterns will vary with cell type throughout the human body.
Slide 7
Lesson 1: Genomic DNA and Genes
The human genome is the complete set of genetic "instructions" for human life. This information resides in genes within very large molecules of deoxyribonucleic acid (DNA). The DNA in the human genome that is passed on to offspring as information necessary for survival is called genomic DNA.
The large DNA molecules are composed of two strands twisted around each other to form a "double helix." Each strand is constructed from millions of chemical building blocks called "bases." DNA contains only four different bases (abbreviated A, T, G, C), but they can be arranged in any sequence. The order of the bases determines the message the gene contains, just as the letters of the alphabet can recombine to form new words. The base sequences of the two strands of each DNA molecule are related to each other by the following rule: A only matches with T, and C only with G. Therefore, the base sequence on one strand dictates the order of the bases on the other strand. This is called "base pairing" and enables the genome to copy itself and pass genomic DNA to the next generation.
Slide 8
Lesson 2: Genes Express mRNA
When a gene expresses itself, it "switches on" to produce a protein. The gene does so by first directing the synthesis of an intermediary molecule called messenger ribonucleic acid (mRNA). To transfer a gene's information from DNA to mRNA, base pairing is used. However, there is one change. RNA uses a new rule: A matches only with U, and C only with G. So the base sequence of an mRNA molecule resembles that of the DNA molecule from which it was copied, except the base U appears anywhere the base T would appear in DNA.
Slide 9
Lesson 3: Expression Changes With Cell Type
Different cell types express a distinct set of mRNAs from their genomes. For example, while a muscle cell (myocyte) and an immune cell (lymphocyte) both possess the same inherited genomic DNA, regulatory networks inside each cell type cause different subsets of these genes to be expressed as mRNA. And sometimes different cell types express the same mRNAs, but one cell type will produce more copies than the other.
Slide 10
Finding Genes With Microarrays
At any given time in each cell in the body, thousands of different genes are active. Until recently, it has not been possible to capture and compare the patterns of gene expression present in different cells in any systematic way. DNA microarrays allow the comparison of thousands of genes that can be measured simultaneously, and the information gained using these arrays is dramatically changing cancer-treatment decisions.
Slide 11
Finding Genes With Microarrays (cont.)
A DNA microarray is a thin-sized chip that has been spotted at fixed locations with thousands of single-stranded DNA fragments corresponding to various genes of interest. A single microarray may contain 10,000 or more spots, each containing pieces of DNA from a different gene. A single gene chip can even hold representative fragments from the entire human genome.
Slide 12
Using DNA Microarrays to Measure Gene Expression
To determine which genes are being expressed in any given cell population, mRNA molecules, which are produced by active genes as they assemble proteins, are isolated from the cells and copied with a special enzyme called "reverse transcriptase." The enzyme copies the mRNA strand by using the DNA rule (see 8), and the copy is called a cDNA. Thus, each cDNA made using reverse transcriptase corresponds directly to a specific mRNA that was coming from an active gene in the cell.
All the cDNAs are then attached to a fluorescent dye. When a DNA microarray is bathed with the fluorescent cDNAs, each cDNA molecule will bind by base-pairing to the spot where pieces of its specific matching gene are located. Therefore, each fluorescent spot in the microarray corresponds to a gene that was actively being transcribed into mRNA in the original cell.
Slide 13
Using DNA to Compare Cancer Cells to Normal Cells
Besides being used to assess the activity of genes being expressed in a single sample, DNA microarrays can also be used to compare the patterns of gene expression in two different cell populations, such as a population of cancer cells with a population of normal cells. In this case, two different fluorescent dyes are used. For example, a red dye can label cDNAs derived from corresponding normal cells, and a green dye, those derived from cancer cells. When the red and green cDNAs are mixed together and placed on a DNA microarray, the green cDNAs will bind to genes expressed in cancer cells and the red cDNAs will bind to genes expressed in normal cells. Green spots represent more copies of a gene being made in a cancer cell, and red spots mean more copies are being made in the normal cell. Yellow spots, caused by mixing red and green fluorescence, represent genes whose expression is roughly the same in both cell types, and black spots, or absence of fluorescence, represent genes expressed in neither cell type.
Slide 14
Making Sense of the Data
Microarrays make it possible to compare the relative expression of thousands of genes in cancer and normal cells by measuring the intensity and color of the fluorescence of each spot. A computer program can then analyze the data and make precise measurements of genes expressed at high levels and low levels. Most microarray studies now include "cluster analysis," which groups together genes that have similar levels of expression.
Slide 15
Microarrays Come In Many Models
There are some standard microarrays for use in cancer research, such as the Lymphochip. Standard arrays include genes that have been reported as important in a certain type of cancer. Other arrays contain strands of DNA called single nucleotide polymorphisms, or SNPs ("snips"), which are common variations in DNA. Researchers also can create their own microarrays using whatever genes (or gene fragments) they think might be important to the questions they are trying to answer.
Slide 16
Cancer-Specific Gene Expression
Microarrays are being used in cancer research with incredible results. For example, researchers used microarrays to compare gene activity patterns in normal stomach tissue and tissue from stomach tumors. They found that the tumor tissue, but not the normal tissue, expressed a gene called PLA2G2A. But they also found that cancer patients with high expression levels of PLA2G2A were more likely to survive for 5 years, compared with patients whose tumors produced lower levels.
Slide 17
Potential Markers for Metastasis
Gene expression patterns are also being used as a tool for improving the diagnosis of breast cancer. Microarrays have been used to examine the expression patterns of some 25,000 genes in tissues from breast cancer patients. Computer cluster analysis of the patterns led to the identification of about 17 marker genes that can correctly identify about 90 percent of the women who would eventually develop metastases. While still experimental, such studies bring hope that clinicians will be able to act much sooner and use new technology to better monitor the women more likely to experience aggressive progression of their breast cancer.
Slide 18
Subtyping Cancer
Researchers also use microarrays to detect differences in patterns of gene activity even within the same tumor type. In many cases, researchers have discovered that what had been considered a single type of cancer--based on how the cells looked under a microscope--was really two, three, or even more subtypes, each with a distinct gene expression pattern. For example, using microarrays, researchers have identified new types of leukemia and discovered that the most common type of lung cancer (lung adenocarcinoma) is actually four distinct types of cancer, each with its own gene expression pattern.
Slide 19
Lymphomas and Microarray Research
One of the first discoveries of cancer subtypes was in a blood cancer called diffuse large B cell lymphoma (the most common subtype of non-Hodgkin's lymphoma). Using a chip that contained fragments of 18,000 genes, researchers found two distinct cancer subtypes. These cancers looked the same under the microscope, but had different patterns of gene activity.
The subtypes were different in other ways, too. For one thing, they arose from different types of cells. Tumor cells of one cancer subtype arose from less differentiated ("younger") lymphocytes, while the other subtype arose from more differentiated ("older") lymphocytes.
There was also a survival difference between the two types. About 75 percent of the people with the "younger" subtype responded to chemotherapy, compared with only 25 percent of the people with the "older" subtype.
Slide 20
Microarray Predicts Survival
Two years later, another gene chip analysis yielded a third subtype of diffuse large B cell lymphoma. It also yielded another advance: Researchers found 17 genes that were strongly related to survival. The scientists created a formula to predict response to chemotherapy based on the expression patterns of these 17 genes. This formula divided B cell lymphoma patients into four groups. Two of the groups had about 72 percent survival rates 5 years after diagnosis. The third group had a 34 percent survival rate, and the fourth had a 15 percent survival rate. The 17-gene predictor formula was better than any current methods at identifying patients with the poorest prognosis. Identification like this is important because if patients predicted to have poor outcomes can be identified correctly early in treatment, they can receive more aggressive therapies right away instead of waiting until standard therapies fail.
Slide 21
Finding New Drugs With Microarrays
Another important use of microarrays occurs in pharmacogenomics, an area of research that studies why certain drugs work in combination with particular genetic expression patterns, but not with others. This information is being used to design new drugs that target cancer cells without affecting normal ones.
Slide 22
HER-2/NEU Protein as Target
Herceptin is a good example of a pharmacogenomics success story. In the 1980s, researchers discovered that some women who had particularly fast-growing breast cancers expressed extra copies of a gene called Her-2/neu. The genes were producing many copies of a protein that appeared to be driving the growth of the cancer cells.
Slide 23
An Antibody Called Herceptin
In the early 1990s, an antibody was developed that latches onto the her-2/neu proteins on the surface of a cancer cell. It stops the proteins from spurring on cancer-cell growth, and through this "stop signal" can also stop propagation of survival signals within the cancer cell. Some women who were given the experimental antibody saw their cancer growth slow or stop altogether when their Herceptin treatment was combined with cytotoxic chemotherapy.
Herceptin was approved by the Food and Drug Administration in late 1998 as therapy for women who test positive for high levels of the her-2/neu protein (about 25 to 30 percent of all breast cancer patients).
Slide 24
Using Expression Patterns to Choose Treatments
With the advent of microarrays, pharmacogenomics research has entered a whole new level of sophistication. This technology allows researchers to study patient populations, collecting expression patterns of tumors before any treatment is given.
By analyzing treatment outcomes, scientists hope to identify expression patterns that can accurately predict a good response to treatment. In the future, before any treatment is given, doctors may be able to predict a patient's response to chemotherapy or radiation based on this research. This could eliminate much clinical "guesswork." One day, simply by looking at expression patterns found in a single blood sample or a small tissue biopsy, doctors may be able to tell a patient which of the available drugs or radiation treatments will work best and which will not. Clinicians will be better able to plan effective therapies at the proper doses for individual cancers.
Slide 25
SNPs Microarrays Check Drug Metabolism
Microarrays will also be useful in studying drug metabolism. Drugs are broken down in the body by proteins, and not all of these proteins are identical from person to person. Genetic variations, called single nucleotide polymorphisms (SNPs), can result in subtle differences in proteins that translate to major differences in how the protein functions. For example, as many as 40 percent of people have a SNP that causes a deficiency in a protein called cytochrome P450 CYP2C9, which is important to drug metabolism. Deficiencies in this protein can impair the metabolism of as many as 1 in 5 medications currently on the market.
Slide 26
Molecular Diagnostics and Proteomics
Another major focus of molecular diagnostics looks beyond genes to an investigation of the proteome. The term "proteome" refers to all the proteins produced by a cell, and the study of these proteins is proteomics. Cancer proteomics is enabling mapping of the patterns of proteins involved when normal cellular pathways are hijacked in support of malignant growth. In cancerous tissue, some of the proteins critical for normal communication are damaged, inactive, overactive, or missing entirely. The full set of deranged and dominating proteins at work disrupting cellular communications may vary from one cancer type to another. They may also vary somewhat from one patient to another within a cancer type.
Slide 27
Proteomics Maps Protein Patterns
Cancer researchers are devising clever ways to capture data on each cancer's characteristic unruly sets of proteins. Biopsy or blood samples from cancer patients are the starting point. Many different methods are being used to extract and analyze the various sets of interactive proteins.
Slide 28
Proteomics Maps Protein Patterns (cont.)
For many proteins in the cell, the addition of a small molecule called phosphate acts as a switch that activates the protein. This process is called phosphorylation. To preserve a cell's phosphorylation state and capture an accurate pattern of proteins interacting in a cancer cell, proteomics researchers must handle the biopsy or blood specimens carefully. They do this by seeing that samples are quickly treated with enzymes to block the removal of phosphates from proteins. This enables researchers to identify a protein pattern almost identical to what was in the cell at the time of collection.
Slide 29
Laser Capture Microdissection
One method being used to minimize cellular damage and capture accurate protein patterns in cancer and normal cells is laser capture microdissection. Researchers use a low-energy laser beam and special transfer film to lift a desired cell out of the tissue section, leaving all unwanted cells behind. They can then collect all the proteins that were present in the selected cells, map the protein pattern, and store the information in a computer database.
Laser capture microdissection offers several advantages for studying proteins. For example, with this technique researchers are able to capture separate sets of cells from normal, precancerous, cancerous, and even stromal tissue, all from the same patient's biopsy sample.
Slide 30
Finding Subsets
After laser capture microdissection, scientists can extract the proteins and use 2-D gels, protein lysate microarrays, and/or mass spectrometry to separate and identify subsets of proteins that may then serve as unique markers for a particular cancer cell type.
Slide 31
Protein Patterns and Diagnosis
Scientists have learned that it is not necessary to identify every protein active in cancer and captured by laser microdissection. To accomplish a molecular diagnosis, all that may be needed is to separate and preserve a unique subset, a pattern of proteins shared by all patients with the same cancer type.
For example, researchers collected blood samples from a group of patients with diagnosed ovarian cancer. They used mass spectrometry to collect all the protein profiles that appeared in the patients' serum samples. While there was some variation from patient to patient, pooling enough samples of confirmed ovarian cancer enabled clinicians to use cluster analysis to determine what subset of proteins consistently served as markers for the presence of cancer. Identification of this subset was successful, and today we are on our way to completing a method of molecular diagnosis for ovarian cancer.
Slide 32
Importance of Diagnostic Test Sensitivity
Molecular diagnostics for ovarian cancer must correctly detect all the women who have this cancer without incorrectly identifying people who do not have the disease.
Slide 33
Importance of Diagnostic Test Sensitivity (cont.)
The first hurdle is a test's sensitivity. Sensitivity answers this question: What percentage of people with a given type of cancer will have their cancer detected when a given screening test is used? If a test is not very sensitive, there will be many "false negative" results, and persons with cancer will go undetected. A test that yields many false negatives will obviously not be very good at reducing cancer deaths, giving a false sense of security to people who actually have the disease.
Slide 34
Importance of Diagnostic Test Specificity
High specificity is important for an ovarian cancer test because this cancer is a relatively rare disease, occurring only in about 1 of 2500 postmenopausal women.
The ovarian cancer diagnostic test is being developed and tested first among women at risk of recurrence for ovarian cancer. If this use is successful, the test will next be extended to women at high risk for developing the disease.
Slide 35
Importance of Diagnostic Test Specificity (cont.)
The next hurdle is a test's specificity. Specificity answers this question: What percentage of the people who do not have cancer are correctly identified as being free of disease? If a cancer test is not very specific, it will yield many "false positive" results; that is, a person will test positive even though they are cancer free. Such error can lead to unnecessary and costly follow-up procedures and cause anxiety in the person misdiagnosed.
Slide 36
From Patterns to Screening Tool
Researchers used the protein patterns they had collected from the ovarian cancer patients along with an artificial intelligence computer program to create and train a new bioinformatics-based screening tool. The program was designed to recognize the presence or absence of ovarian cancer in blood samples of unknown cancer status.
Slide 37
From Known Samples to Serum Proteins
Scientists next asked if a new bioinformatics-based screening tool for ovarian cancer could be created using low-molecular-weight proteins in blood serum as the biomarkers. Could this tool accurately handle specimens of unknown cancer status? If so, researchers could devise a minimally invasive test for the detection of early-stage ovarian cancer. If so, their bioinformatics-based technology might also have broad application to the early diagnosis of many other cancers as well.
Slide 38
Molecular Mop
A major problem in the identification of cancer biomarkers is the very low concentrations of markers coming from tissues with small, early-stage cancer lesions. Fortunately, investigators have found a new way to amplify and concentrate these biomarkers in the blood. When scientists searched for protein patterns in the serum of ovarian cancer patients, they came upon an interesting discovery. The albumin molecule and other long-lived carrier proteins that circulate in the bloodstream act as molecular mops, grabbing a lot of low-molecular-weight proteins as they are degraded and prepared for elimination from the blood. The "mop" actually helped them collect and amplify, more than 100-fold, the low-abundance serum protein patterns needed for analysis.
Slide 39
Serum Proteins Can Serve as Markers
The researchers succeeded in showing that a subset of low-molecular-weight proteins from the serum of patients formed predictive patterns that could be used experimentally to mark the presence of ovarian cancer.
They detected a diagnostic pattern of five proteins in the blood of women with ovarian cancer that is not found in the blood of other women. Experimentally, in a limited subset of test patients, the test has had a sensitivity of 100 percent and a specificity of 100 percent.
Slide 40
Molecular Diagnostics Has Many Uses
Clinicians have discovered that molecular diagnostics has many uses beyond the creation of new screening and diagnostic tools. Expression patterns also can provide information for the design of new cancer treatments, monitor the treatment's effectiveness as it is studied in a clinical trial, and even predict the patient's response to a new treatment.
Slide 41
In the Future
Picture this: A cancer patient visits her oncologist, gives a few drops of blood or a biopsy specimen, and is told that her genetic expression pattern shows she has a certain subtype of disease. Meanwhile, another expression pattern predicts that her genetic profile should respond well to chemotherapy regimens A and B (with minimal side effects). During her treatments, protein expression patterns are used to make sure that her treatment is effectively disrupting the targeted cellular pathway in her tumor. After treatment, more gene and protein expression patterns verify that the cancer is in remission.
Slide 42
Clinical Trials: Making the Future the Present
Molecular diagnostics and its newly developed techniques for examining the molecular signatures of cancer cells--protein as well as gene patterns--offer great promise for revolutionizing our approaches to screening, diagnosis, and classification for many different kinds of cancer. Participation in the clinical trials that will validate these new approaches will lead to significant improvements in care for cancer patients in the not-too-distant future.


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New Video Series from NOAA Now in ARC
Archives Specialist Marcia Kolko reports that descriptions for nine small series of video recordings from Record Group 370, National Oceanographic and Atmospheric Administration (NOAA) have recently been uploaded to our online catalog, the Archival Research Catalog, ARC. The series document a range of NOAA surveys and projects, including documentation of an emergency response drill in the Florida Keys […]
Posted by Carol on April 2, 2013, under Preservation, Reference, Video Recordings.
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BBC has put together a great page featuring video from all thirteen regenerations of the Doctor. It may take you a little time to watch them all, but this is a wonderful stroll down memory lane for fans of Doctor Who.
BBC Video: Watch the Doctor's 13 regenerations
Matt Smith was the most recent to regenerate during "Time of the Doctor", which aired on Christmas Day. Peter Capaldi has taken over the role with new episodes scheduled to begin airing later this year.
Here are my cheers and jeers...
Worst Regeneration
The Fourth Doctor (Tom Baker). I'm a big fan of the classic Tom Baker episodes. However, the Baker regeneration sequence features some kind of weird death shroud that absolutely ruins the transformation.
Most Touching Regeneration
The Ninth Doctor (Christopher Eccleston). Eccleston is perhaps one of my least favorite actors to play the Doctor. However, the goodbye between Rose and the Doctor is very memorable. His last words to Rose are quite touching. "You were fantastic. Absolutely fantastic. And you know what? So was I."
Best Entrance by a new Doctor
The Twelfth Doctor (Peter Capaldi). "Kidneys! I've got new kidneys!"
"Let's Get it Over With" Regeneration
The Second Doctor (Patrick Troughton). The regeneration sequence is so long that's you're almost cheering when the Doctor finally transforms.
Best Regeneration
The Tenth Doctor (David Tennant). Tennant is hands down my favorite of the Doctors. My eyes welled up as he looked around the Tardis for the last time and said tearfully, "I don't want to go."
Greg Belfrage is a lifelong Star Trek fan, Batman toy collector, sci-fi movie maniac and hopeless geek. He can be contacted at firstname.lastname@example.com.


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Funeral services for Mrs. Evelyn Townsend Barham,92, will be held Wednesday, April 20, 2011 at 10 a.m. in Sacred Heart Catholic Church with Father Mark Franklin officiating. Interment will follow in Springhill Cemetery under the direction of Bailey Funeral Home, Springhill.
Visitation will be held today from 5 until 7 p.m. with Rosary to follow at 7 p.m. in Bailey Funeral Home Chapel.
Mrs. Barham was born Sept. 21, 1918 in Minden to Edward F. and Barbara Eardhart Townsend and passed away April 17, 2011 in Springhill, following a short illness.
She was a native of Minden and resident of Springhill. Mrs. Barham was a member of Sacred Heart Catholic Church, a member of the Ladies Altar Society and American Legion Auxiliary. She retired from Webster Parish School Board after teaching many years in the Springhill Elementary School System.
She is survived by her daughters, Kay Hughes and husband, Charles and Ruth Barham, all of Springhill; sons, Grey G. Barham and wife, Carol of Tomball, Texas and Michael R. Barham and wife, Barbara of Pineville; grandchildren, Greg Hughes of Lewisville, Texas, Staci Vaughan and husband, Jess of Sarepta, Justin G. Barham and wife, Heather of Dallas, Texas, Lindsay B. Smith and husband, Chad of Tomball, Texas and Michael Hare and wife, Jamie of Silver Spring, Maryland; and nine great-grandchildren.
Mrs. Barham was preceded in death by her parents; her husband of 56 years, Greg Sullivan Barham; and her brother, Bernard Townsend.
Pallbearers will be Anthony Manuel, Greg Hughes, Jess Vaughan, Justin Barham, Bill Grimes, Floyd Sterling and Joe Townsend. Honorary pallbearer will be William F. "Billy" Smith, Sr.
In lieu of flowers the family requests memorials to be made to Sacred Heart Catholic Church, P.O. Box 799, Minden, LA. 71058
Sign the online guestbook at www.baileyfuneralhome.net.


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Palo Alto Medical Foundation
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Pediatrics Physician Status: Open Spanish Santa Cruz Aptos Office
Pediatrics Physician Status: Open Spanish Santa Cruz Aptos Office
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Susan E. Borba, M.D.Palo Alto Medical Foundation
Main Clinic (Santa Cruz)
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(831) 458-5555
Location(s): Aptos Office, Main Clinic (Santa Cruz)www.pamf.org/dr-susan-e-borba.html
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Offers My Health Online This provider offers Sutter Health's electronic health record with the following online services: Email your doctor's office, Prescription refills, View test results, Proxy access for caregivers, Track immunizations, Secure mobile access, Schedule an appointment*, Pay bills online*. * Services with an asterisk vary by doctor.
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Assassin's Creed Brotherhood Coming to PC in MarchThe long-awaited PC edition of Assassin's Creed Brotherhood will finally be released on March 17 in North America, Ubisoft has quietly announced on the open-world murder simulator's official forums.
Assassin's Creed Brotherhood was released for Xbox 360 and PlayStation 3 back in November 2010. The PC edition was initially expected to launch alongside the console versions, until Ubisoft revealed otherwise in September. Hopefully it'll be one of the PC games Ubisoft tones its DRM down for.
Ubisoft confirmed yesterday that a mysterious, new, "packaged" Assassin's Creed game will be released some time this year. Not a Facebook game then, at least.


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A man was discovered shot to death inside his own home on Old Homestead in Harper Woods just blocks away from the police department.
"Why would somebody want to do something to a great guy like him?" said Nathaniel Davis, Junior.
Davis just can't believe it. He and Joe Tate have known 60-year-old Johnny Buckner for 40 years. They grew up together, worked at General Motors together and retired together.
Tate just spoke to him on the phone Wednesday afternoon. He was driving home.
"He said, 'I'm on my way to the house.' And that was it. He said, 'I'll talk to you tomorrow.' End of conversation," Tate explained.
The last conversation. The two men would not talk the following day. At 11:25 p.m. Wednesday, Buckner's grandson found him in the home murdered, shot multiple times.
"We believe that whoever was responsible for the shooting stole the victim's car. It's a 2001 Cadillac DeVille four door. It's cream in color with a dark tan roof," Harper Woods Police Chief Jim Burke told me.
Burke said finding that car is key. It has a Michigan license plate 8JW A60.
Did the gunman force his way into the house or was he perhaps let inside? Did the victim know his attacker? Those are things that Harper Woods police are not yet saying.
"It's a very safe, secure, solid neighborhood and it's very unusual that something like this would happen, but obviously the neighbors are quite shaken up and we're doing everything we can to track down who did it," Burke said.
Frightening for neighbors and so sad for Buckner's family and friends. His wife had passed away a couple of years ago and his friends say he was just starting to smile again.
"We had been worried about him because he lost his wife, but he seemed to be getting it back together and start laughing and start living life again. It's just so tragic," said Davis.
Anyone with information is asked to contact Harper Woods police or Crime Stoppers at 1-800-SPEAK-UP.
KDFW FOX 4400 N. Griffin StreetDallas, Texas 75202
Main Station Directory:(214) 720-4444News Fax:(214) 720-3263 or (214) 720-3333


text: Be aware of a new virus in Michigan killing dogs! It seems similar to a virus we talked about a few weeks ago called Circovirus. It's not yet known how the disease is being transmitted and the SCARY part is, pet owners who are sick with flu-like symptoms appear to be the ones making their dogs sick. Passing viruses on to our pets is unusual, but possible. So far, the virus has only effected dogs, but some dogs have died within 24 hours after getting sick. DON'T WAIT if your dog begins experiencing flu-like symptoms (vomiting, lethargy, abdominal pain, bloody diarrhea) Contact your vet immediately. http://www.wxyz.com/dpp/news/region/washtenaw_county/a-deadly-virus-getting-dogs-sick-in-metro-detroit-is-being-seen-in-michigan-for-the-first-time