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NEW HAVEN, Conn. – For the first time in a long time, the Yale women's swimming and diving team will be led by a diver. Rachel Rosenberg, an art major in Davenport College who hails from Strongsville, Ohio, is the senior-most member of the small but distinguished Bulldog diving squad. Rosenberg will take over leadership duties from outgoing captain Annie Killian.
"I am so honored to have the privilege of leading the team for the next year," said Rosenberg. "The swimmers and divers have always been very close, and now this marks our final unification. Annie has done an incredible job keeping the team positive through last season's full coaching staff overhaul."
When Rosenberg arrived in New Haven in the fall of 2008, Frank Keefe was still at the helm of the Bulldog swimming and diving program. It was announced in the spring of her freshman year that Keefe would step down after the 2009-2010 season, making way for Cristina Teuscher to step in as Robert J.H. Kiphuth Director of Swimming and Diving and for Toni Pullman to come on as assistant coach. Most recently, Chris Bergère was brought on as the team's new diving coach just days before this season's home opener against Columbia. Rosenberg will be working closely with Teuscher, Pullman, Bergère and her fellow seniors in leading the team to a winning season next year.
As a sophomore Rosenberg was conference champion in the three-meter event. She placed first at the 2010 Ivy League Swimming and Diving Championships with a score of 291.60, for which she received first team All-Ivy honors and was named Diver of the Meet.
Rosenberg's best meets this year were at Navy and home against Brown. She broke 300 points on three-meter at both meets, a milestone in diving she had not previously achieved. She also won the one-meter event against Brown, putting up 290.92 points to set a new personal record by 15 points. Two weeks later at the Ivy League Swimming and Diving Championships she placed 10th on three-meter and third on one-meter. She finished her season at the NCAA Zone A Diving Championships where she placed 23rd on one-meter and 14th on three-meter.
"For spring training and next season I hope to continue on the same path toward achieving our goals within the league and beyond," said Rosenberg. "We've got an incredibly talented class of freshmen joining us in the fall and are anticipating an exciting year of fast swims and ripped dives. This team is growing into something great and I'm proud to be able to represent it on campus and abroad."
Report filed by Tom Lynam '13, Yale Sports Publicity


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Ken Salazar's Voting Record in the U.S. Senate By Discover The Networks 2011
Drilling Ken Salazar By Michelle Malkin March 23, 2011
The Interior Department's Culture of Contempt By Michelle Malkin February 4, 2011 Ken Salazar Needs Another A**-Kicking By Michelle Malkin July 16, 2010
Ken Salazar was born in Alamosa, Colorado in March 1955 and was raised, with seven siblings, in nearby Manassa. His parents were ranchers in the San Luis Valley. After earning a bachelor's degree in political science from Colorado College in 1977 and a J.D. from the University of Michigan Law School in 1981, Salazar ran a private law practice for several years. Next, from 1987-1994 he served in the cabinet of Colorado Governor Roy Romer—first as chief legal counsel, then as executive director of the Colorado Department of Natural Resources. In 1994 Salazar resumed his private law practice. Four years later, he ran successfully for the office of state attorney general. In 2002 he was re-elected to that post and served as chairman of the Conference of Western Attorneys General. In 2004 he won the race for a U.S. Senate seat in Colorado; a notable organizational supporter of Salazar's Senate campaign was the Council for a Livable World. That same year, Salazar's older brother John was elected to represent Colorado's 3rd Congressional District in the House of Representatives. In 2005 Ken Salazar co-sponsored the Vehicle and Fuel Choices for American Security Act, which would have required the federal government to develop a strategy to cut U.S. oil consumption by 10 million barrels per day by the year 2031. In 2007 Salazar co-sponsored a bill calling for more research into the possibility that America's arid Western states might be prone to "experience the effects of climate change sooner and more intensely than most other regions." In November 2007 Salazar stressed the need for the U.S. to move away from fossil fuels in order to "improve our energy security and reduce our dependence on foreign oil"; reduce the likelihood that "we will continue to be entrenched in conflicts over resources in every corner of the world"; and "triumph in our fight against oil-funded extremists and terrorists." Throughout his tenure in the U.S. Senate, Salazar strongly opposed the George W. Bush administration's efforts to open land in Colorado and other Western states to oil-shale development, citing concerns about "whether the [oil-shale] technology is commercially viable,... how much carbon would be emitted,... [and] what the effects would be on Western landscapes." Similarly, in 2008 Salazar vowed to reject all new offshore oil-drilling ventures—even if gasoline prices were to reach $10 per gallon. For an overview of Salazar's voting record on key legislative items during his years in the Senate, as well as the performance ratings he received from various special-interest groups, click here. In December 2008, President-elect Barack Obama asked Salazar to head the Interior Department of his forthcoming administration. The Senate confirmed Salazar for the post on Obama's inauguration day, January 20, 2009. As Secretary of the Interior, Salazar has continued to aggressively block efforts to lease oil-shale rights in the Western United States, as well as efforts to initiate offshore oil- and gas-drilling projects -- a position that hardened after the 2010 BP/Deepwater Horizon oil leak into the Gulf of Mexico. In a report which he issued on May 27, 2010, Salazar recommended a six-month moratorium on all deepwater drilling—notwithstanding the fact that five out of seven consulting engineers had stated that such drilling had a strong safety record, and that targeted inspections would be more sensible than a blanket moratorium. In June 2010, federal judge Martin Feldman of Louisiana ordered Salazar and the Obama administration to lift their "arbitrary and capricious, and therefore, unlawful" ban on offshore drilling in the Gulf. The following month, when a U.S. Court of Appeals denied Salazar's bid to put a hold on Feldman's order, the Interior Secretary promptly concocted a second, "revised" moratorium to replace the one Feldman had nullified. Though Salazar officially "lifted" this second ban three months thereafter, he issued no additional drilling permits that year. Rather, in 2010 he actually rescinded 77 oil-lease contracts that had previously been granted—after seven full years of rigorous study and debate—during the final days of the Bush administration. Federal courts repeatedly scolded Salazar and the White House for their "determined disregard" of judicial orders and their "increasingly inexcusable" action on stalled deepwater drilling projects, to no effect. In February 2011, Judge Feldman—complaining that the Obama administration's "time delays at issue here are unreasonable"—ordered Salazar and the President to decide within a month whether they would grant a set of five permits for deepwater drilling projects in the Gulf of Mexico. Obama and Salazar chose not to comply for several weeks, and instead issued yet another request to the 5th Circuit Court of Appeals for a stay of Feldman's order. Finally, in March 2011 Salazar gave the Shell Offshore Company permission to apply for drilling permits for three new exploratory wells off the Louisiana coast. In mid-March 2011, Salazar angered many environmentalists when he characterized coal as "a critical component of America's comprehensive energy portfolio," and announced that nearly 758 million tons of Wyoming coal would go up for sale in the coming months. Soon after Salazar's announcement, three environmental groups—Defenders of Wildlife, the Sierra Club, and WildEarth Guardians—issued a joint statement criticizing the decision.
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I really don't think there's anything wrong or amiss here, but we have noticed that Simo is generally a very silent bird. He does vocalize, most notably he has these silent but distinctive squawks. So far he seems to have learned no words - but he did learn to laugh, which he picked up literally in an hour after I started to go "hahaha" after him. I wonder, could this be a case of the "shy talker bird?" Meaning, he speaks when maybe we're not around to see it?
I'm honestly not bothered weather he'll ever learn to talk "human" or not, but I am curious if he does it when no one hears! I know that Ringnecks are good talkers, and we talk to him reguarly, repeating many words. At times I catch him moving his beak and I hear faint whispery sounds, but not words.
Or could he still be too young? I've heard that the age they properly pick up words can vary an awful lot. Some IRN learn it at only half a year old, some when a bit older. I'm not bothered if he's a silent thinker but it'd be nice to hear some thoughts on this.


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U.S. Rep. Steve Cohen of Memphis told a national television audience Monday, July 22, that he wants to "get back to doing important work."
Cohen made the comment during a live interview on the MSNBC program "Morning Joe," in which he talked more about the DNA tests results showing he is not the father of Victoria Brink, the woman Cohen said earlier this year was his daughter.
The interview was the first chronology the Memphis Democrat has offered of the personal story that became a national one when Cohen tweeted Brink during the State of the Union address in February.
U.S. Rep. Steve Cohen, D-Memphis, discussed his recent paternity test on MSNBC's "Morning Joe" Monday, July 22.
(Daily News File Photo/Lance Murphey)
He said Brink's mother, Cynthia White Sinatra, told him in 2010 that he was Brink's father and that she had told her daughter a year earlier.
Cohen said the only other person outside of the three to know was entertainer Frank Sinatra Jr., her former husband.
"And she told him in case she passed first, that he would know if Victoria needed any body parts who would be right," Cohen said. "She, I think, thinks I'm the father now."
When the story broke this past February, Cohen said John Brink, who it turned out is Victoria Brink's biological father, wanted the DNA testing. The first test showed John Brink was the father.
"Then the mother didn't believe the test nor did the daughter. So they asked me to do another test. I did the test for her," Cohen said of Victoria Brink. "I had no thought it would come back anything but that I would be the father."
The second test results confirmed again that John Brink is the father and those results were the CNN story that aired last week.
Program host Mika Brzezinski said Cohen helped to make it more of a story with tweets.
–U.S. Rep. Steve Cohen
"Keep it off Twitter, we won't cover it," she told Cohen.
"The press has made this a story. This is a personal tragedy that should be allowed for me and Victoria to deal with independently," Cohen replied. "She's hiding out in Houston. She's hated it. … I'm tired of it."
Several times during the interview, Cohen also dropped in comments on legislation he is working on as he put together the chronology of the personal story.
He also said constituents in the Memphis district "don't look at me as a white person" after Brzezinski showed a tweet from Cohen in which he tweeted that a black tow truck driver told him he is "black."
"It was funny. I had a tough night. I drive an '86 Caddy. A lot of African-Americans drive old cars," Cohen said. "Stereotype? It dies twice in two weeks. Albert King didn't have bad luck, had no luck at all. I'm having no luck."
"I hear it in Memphis all the time," he added. "My constituents don't look at me as a white person."
Copyright 1995 -
by The Daily News Publishing Co. Inc. - All Rights Reserved


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All of your application materials should be submitted directly online to your UW Graduate School Application file.
When applying online, read and follow all instructions carefully. Please plan to attend an information session for detailed information about the program and application process.
* Beginning September 1, 2014, WA state requires NES assessments for English/Language Arts or Mathematics endorsements. (Transition information available.) If you have already take the WEST-E in either of these subjects prior to September 1, 2014, you are not required to take the NES assessment and may submit the WEST-E score report with your application.
Respond to the following questions. Your responses to all the essay questions must be contained within no more than three double-spaced pages. The relative length of each of your responses within these three pages is up to you, but the Admissions Committee will not read responses beyond the third page.
You may submit your essay directly to your UW Graduate School online application as a Word, PDF, or RTF document.
Provide three recommendations.
Recommendations must be submitted electronically by entering the recommenders' names and email addresses into your online application.
Document a minimum of 60 hours of work with secondary and middle level school youth within the past two years. At least 30 of these hours must be in U.S. public middle school or high school classrooms. These hours must be completed prior to the application deadline. Additional hours of observation and experience in public school settings are highly recommended. The documentation of hours form(PDF) is available online and may be duplicated.
All applicants must document their college coursework that meets the requirements for the desired endorsement area(s). For examples of coursework that meet these requirements, refer to the Endorsement Course Requirements.
Document your endorsement area coursework, including the number of credits and grades (a minimum grade of 2.5 in coursework is required), on the Transcript Review Form(s) and save them to your computer. You may upload the saved PDFs to your Graduate School online application file.
If you have questions about the required endorsement area coursework, please contact the Secondary and Middle Level Teacher Certification Program and include your desired endorsement area.
All applicants to Washington-approved teacher preparation programs are required by the state to take the Washington Educator Skills Test-Basic (WEST-B).
The test consists of three separate subtests:
Please read the information carefully on the WEST-B website for test dates and score reporting dates. Score reports are a requirement for the Secondary Certification application.
Candidates entering a Washington approved teaching preparation program may substitute a passing score on one or more sections of the SAT or ACT for the equivalent passing scores on the WEST-B. More information, with specific numeric passing scores are located on the Professional Educator Standards Board (PESB) website. If applicable, SAT/ACT score reports are a requirement at time of application.
All candidates for secondary endorsements in General Science, Biology, Social Studies, and History are required to pass the appropriate WEST-E test. (For more information on the WEST-E tests, please visit the WEST-E Website).
The following is a list of the corresponding WEST-E test numbers:
West-E Preparation Materials at the UW Bothell/Cascadia Campus Library
All candidates for secondary endorsements in English/Language Arts or Mathematics are required to pass the appropriate NES assessment.*
* Beginning September 1, 2014, Washington State requires NES assessments for English/Language Arts or Mathematics endorsements. (Transition information available.) If you have already take the WEST-E in either of these subjects prior to September 1, 2014, you are not required to take the NES assessment and may submit the WEST-E score report with your application.
As of September 1, 2014, Washington State requires NES tests for English Language Arts or Mathematics endorsements. WEST-E scores for test taken prior to September 1, 2014 will still be accepted.


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Sorry gentlemen, but I did have posted description, for some reason they're not shown and I was unable to post a photo I had no idea why, if you need photos I can send directly to your email, just ask. Sorry for this.
For a $3,000 radio, you might want to post some more information. Maybe even a picture?
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I'm ready to discuss. Please sent foto and condition information on email firstname.lastname@example.com
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Nordelle Robinson Kelly — Madame Kelly to her pupils — who taught French for two decades in the schools here, died of complications of colon cancer on Aug. 16 at home in East Hampton.
Mrs. Kelly, who moved to East Hampton with her husband, Raymond F. Kelly, in 1974, held several culinary positions before settling on education. She had a bread-baking business, having convinced the owners of the mill in Water Mill to operate the grinding stone there, turning her sacks of wheat into flour. Her bread was the only bread ground by that mill in many years. She also worked as a private cook and pastry chef at the Royal Fish and the Laundry restaurants.
She was born on March 9, 1937, to Vincenza Lillian Mastropaolo and Frank Robinson and grew up on Staten Island. She enrolled at Wagner College there and became a French major. "She was a true Francophile," said her son, Christopher Kelly of Brooklyn. She taught herself professional cooking techniques and concentrated on all things French — the language, food, music, art, and literature.
For a time she was an assistant in cultural services at the French Embassy in New York City. Upon earning her teaching degree, she embarked on a special program in the French city of Besancon, and later Limoges, where she taught English.
She was later a French instructor at Queensborough Community College, and in the early 1980s Mrs. Kelly began teaching at the Springs School while pursuing a master's degree at the State University at Stony Brook. She traveled to France again to study at university programs in Angers and Poitiers.
In 1986, she started teaching French at East Hampton High School and the middle school, continuing until 1997, when she took early retirement because of complications from Lyme disease.
After retiring, Mrs. Kelly enjoyed a peaceful life at home in East Hampton, spending time with friends and family, gardening, and privately tutoring a handful of students.
Her cancer diagnosis preceded her death by only a few months. In addition to her son, she is survived a daughter, Nina Kelly of Stuyvesant, N.Y., and two granddaughters. A brother, Charles Robinson of Picayune, Miss., and a sister, Ann Despont of Mendham, N.J., also survive.
Memorial contributions can be made in Mrs. Kelly's name to the Retreat, 13 Goodfriend Drive, East Hampton 11937, or to the Animal Rescue Fund of the Hamptons, P.O. Box 901, Wainscott 11975.


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Cave and Karst Institute Sets Ground-Breaking Ceremony, Nov. 17, 2008
By Thomas Guengerich
CARLSBAD, N.M., Nov. 17, 2008 – The National Cave and Karst Research Institute is one step closer to having a home of its own.
Carlsbad city councilors awarded a $5.2 million bid for the construction of the National Cave and Karst Research Institute to Greer Construction, a Carlsbad firm, in September. On Monday, Nov. 24, the partner agencies will gather for an official ground-breaking ceremony to mark the beginning of a new era for the Institute.
"All the partners are really excited," said Carlsbad city administrator Harry Burgess.
Burgess, who is also a member of the Institute's board of directors, said the ground-breaking ceremony represents an important milestone.
"The city has been supportive of the Institute every since it was designated by Congress and the city is very interested in seeing it have a permanent home in Carlsbad," Burgess said.
The Institute is a non-profit corporation, collaboratively created and supported by a partnership between the National Park Service, New Mexico Tech and the City of Carlsbad.
Dr. George Veni, director of the Institute, said he's excited about the building.
"Having a facility will make us fully functional," he said. "Money we could use to hire additional staff is being set aside to outfit the building. The building is a huge hurdle. Once we're past that, we can hire more people and really fly."
The 17,315 square-foot building will be one-of-a-kind. In addition to exhibits, offices, a lab, library and bookstore, the Institute is the world's first building designed to include a roost for a popular denizen of caves – bats.
The building is planned as an example of efficiency and low environmental-impact. Caves and karst landscapes contain some of the most fragile and vulnerable aquifers and ecosystems on Earth.
"It's important for us to use a building that can serve as a model for living gently on the landscape," Veni said. "While we'll have our main exhibits focus on caves and karst, we'll have many subtle exhibits notifying visitors about the features that are energy efficient or water efficient."
"Karst" is a term that refers to a type of landscape formed mostly by the dissolving away of the bedrock over millennia. Fractures in bedrock, enlarged by natural slightly acidic water, become conduits for groundwater and habitat for a wide range of lifeforms.
"Karst is a landscape characterized by caves, sinkholes and underground streams," Veni said. "You'll find the largest springs in the world in karst because karst springs are fed by caves, which are essentially natural pipelines that can move a lot of water."
Carlsbad was founded on its current site because of the availability of water.
"Without the Carlsbad Springs along the Pecos River, the city wouldn't exist where it is," Veni said.
Understanding karst is vital for hydrologic studies across about 25 percent of the U.S; however, karst is not well understood, even among many geologists, engineers, and land managers.
"I got my bachelor's degree from a university built on top of a karst aquifer," Veni said. "In all my classes, we spent maybe 30 to 45 minutes discussing karst and much of it was wrong. For my master's and doctorate, I had to chase experts all over the country. Many people doing karst management and cave research don't really understand it."
Hence, the creation of the National Cave and Karst Research Institute. And where better to put such an institute than in the city most famous for caves – Carlsbad, New Mexico.
The Institute's long-range mission is to conduct karst research and education, and develop sound management practices that have national and global implications – and to share that knowledge with anyone interested.
Initially, the two main areas of research are geology and biology – or, to be more specific, hydrogeology and geomicrobiology.
Dr. Lewis Land is the Institute's hydrogeologist. His work focuses on underground water resources. Dr. Penny Boston, an Earth Science professor at New Mexico Tech specializing in geomicrobiology, is the Institute's associate director of academics and focuses her research on microbial life found in caves. Along with a host of Tech students supported by the Institute, she examines how microbes affect cave development, potential pharmaceutical applications and the how life in caves might serve as an analog for life on Mars or other planets.
As the Institute develops and grows, Veni expects to form more partnerships with universities, government agencies and research institutes around the world.
"Some people might have worried about having too many cooks in the building's design," Veni said. "Quite the opposite. We had a lot of cooks refining this building into a real fine product."
The Institute suffered several setbacks since receiving funds for the building in 2003, but all of the partners are relieved to finally be moving dirt.
"We're just about there," Veni said. "And I'm glad."


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Virginia embodies GOP's woes
RICHMOND, Va. — Look no further than Virginia to catch a glimpse of the GOP's national dilemma.
As the Old Dominion becomes a firmly centrist state, more closely resembling the rest of the country demographically and politically, Virginia Republicans are shifting rightward.
Story Continued Below
After President Barack Obama carried the state twice, it's plausible that the party will nominate a slate of three movement conservative white males for governor, lieutenant governor and attorney general next year.
( Also on POLITICO: Right up in arms on paper's gun map)
At a traditional party gathering earlier this month called "The Advance," Virginia GOP leaders said there was no need to retreat — or even accommodate.
Attorney General Ken Cuccinelli, the GOP's presumptive gubernatorial nominee, was defiant at the gathering, citing Virginia Republican revivals in past years following Democratic presidential wins.
Cuccinelli scorned what he said were "media" calls for GOP "change, re-evaluation, remake, retreat."
But that's precisely how Gov. Bob McDonnell won so convincingly in 2009, one year after Obama carried Virginia by 7 percentage points, and it's the same path many Republicans expect Cuccinelli, a tea party favorite, to embrace next year if he's serious about keeping the governor's mansion in GOP hands.
McDonnell surely wouldn't cotton to calling his repackaging from anti-abortion crusader and Pat Robertson acolyte to a "Bobs for Jobs," son-of-northern-Virginia pragmatist as any sort of retreat. As he often notes, he remains an unapologetic social conservative.
( Also on POLITICO: 13 people to watch in politics in 2013)
But in an interview here, the governor, who just finished a stint as Republican Governor's Association chairman and will consider 2016 presidential run, was abundantly clear about what sort of campaign he expected Cuccinelli to run.
"After you convince all of your conservative Republican allies and voters in the state that you're right on those issues, you then have to find a way to capture the majority of the independent vote that represent 30 percent or 40 percent of the electorate," McDonnell said, speaking generally and careful to avoid mentioning the attorney general by name. "And many times that's as much a matter of tone and style."
By that logic, wouldn't nominating Cuccinelli, a hard-charging conservative who has sought a national profile, be a risk?
"No," McDonnell shot back. "Because people grow into the office, and they grow into being a candidate."
Whether Cuccinelli, who admits his own blunt style can be "cold-blooded," is willing or able to pull off such a McDonnell-like reinvention is on the minds of demoralized Republicans on both sides of the Potomac.
Some Republicans who attended an Alexandria fundraiser for Cuccinelli earlier this month came away less than impressed, saying he rambled and sounded more like an overly earnest pundit than a candidate.


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Chris Paul pulled his right hand out of his pocket and looked intently at his thumb, almost as if he were trying to see beneath the skin.
The Clippers' point guard sprained his thumb Feb. 21, adding to what has become a maddening succession of injuries. The sprain came after he separated his right shoulder Jan. 3 and sat out 18 games, but before the groin tweak he felt March 10 and the left ankle he rolled last Monday.
"It's all right," he said of the thumb, though it probably isn't, at least not entirely.
Between the thumb, sore groin and ankle, Paul is taking a long time to get taped up before games these days.
"Feels like it," he said Thursday, "but I'm going to get through it, I guarantee you that."
Paul will push through it because that's his nature and because he knows the Clippers need him to lead them in perseverance even as he leads the NBA in assists, with an average of 10.9 per game. He's also a breath from leading the league in steals with an average of 2.44 through Wednesday's games, behind only Minnesota's Ricky Rubio's 2.45. He has led the NBA in assists twice and in steals five of the last six seasons.
While Blake Griffin has elevated his game and Coach Doc Rivers has brought credibility, calm and championship experience to a franchise that urgently needed all of those qualities, the Clippers' playoff fate still rests heavily on Paul and his ability to effectively overcome those nagging injuries.
Rivers joked that during games it's often tough to get Paul off the floor, "which is good," but that Paul might not feel quite so fine the next day in practice. Clearly, Rivers is keeping an eye on him.
"I worry sometimes that he's not forthright in his injuries, so you have to be careful with him," Rivers said. "I'm still learning the guys and he's one of those guys that you've just got to watch to make sure he's telling you the truth.
"You just worry about him because he plays a very physical guard game. He's not a finesse guard. He's a tough, physical guard. But he's not that big, and so you do worry about him."
Rivers' biggest worry?
"His hands," Rivers said. "It's funny. I worry about his hands more than anything, which haven't been hurt. But he's a reacher.… I look at him and worry about his hands, because without those you're not very good. He's always in there and reaching so you have some concern."
Maybe Paul hasn't been quite so forthright about the thumb. Or maybe he's simply determined to manage whatever discomfort he feels because that's what leaders do when they're most needed.
Jamal Crawford paid tribute to Paul's resolve by invoking some heavy hitters, including Kobe Bryant, Michael Jordan and Isiah Thomas.
"He's tough," Crawford said of Paul. "I guess in our game we all make comparisons and I don't want to jump too far but I think he's this generation's Isiah Thomas when it comes to toughness and leadership and doing whatever it takes to win, and moxie in that point guard position. There are so many similarities there.
"Isiah was one of a kind. Just like Kobe and MJ, I think there's not another MJ, but for this generation, Kobe is the closest we'll see. And I feel like that with CP and Isiah as well."
Paul was flattered by the comparison to Thomas.
"Isiah's one of the best to ever play and Isiah won a championship, so I'll take that one," he said.
Thomas actually won two championships, in 1988-89 and 1989-90. Paul hasn't gotten past the second round of the playoffs, nor have the Clippers since the franchise moved to the West Coast.
This season might be his and the Clippers' best shot to reach the promised land of the conference final — or beyond. They were 12-6 while his shoulder healed, a testament to their depth. And they made an impressive statement by reeling off 11 straight wins — before losing Monday at Denver — and regaining their grip on home-court advantage in the first round, which they were in danger of letting slip away.
"No time like the present," Paul said. "We know what we have, you know what I mean? I think at times, in years past, you may question this or question that. I think right now we know who we are. We know what type of team we are and we've just got to be that.
"We're a team, we have our principles. We don't fight. We're going to defend every night. Never settle for less."
Thumbs up to that, taped or otherwise.
Twitter: @helenenothelen


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Call type: Scam
Rating: -5
International clicking then lady with Indian accent claimed to be from talk talk and that my internet line was insecure. Even went to the extent of claiming an engineer would be out on Monday (Bank Holiday!) before wanting me to go online on a computer. No doubt that would have been to enter a website allowing remote access but we didn't get that far.
Bestway, 2019-05-25 12:26:24
Number: 0116 0083957
Call type: Telemarket
Rating: -5
Called 'about the accident you had'. Name sounded like 'Bestway'. They hung up when I asked to repeat their name.
Monika, 2019-05-25 11:04:47
Number: 07944 491995
Call type: Unknown
Rating: 0
Didn't get to landline phone in time - did not leave message.
Martina, 2019-05-25 05:48:20
Number: 07545 211613
Call type: Harassment
Rating: -5
Keeps calling me being rude and getting filthy over the phone even after informing him I'm married
simon, 2019-05-24 18:40:54
Number: 07941 345454
Call type: Harassment
Rating: -5
this number keeps calling me on landline and being weird and becomes aggressive on the phone .. will be reported to the police
Jjklmn, 2019-05-24 17:56:09
Number: 07802 295542
Call type: Harassment
Rating: -5
Called me asking if I was chantelle, a 14 year old girl he'd been texting.
Trying to find out who he is so I can report to authorities as phone number is now going straight to answer phone.
Sick individual who needs stopping asap
Nigel, 2019-05-24 16:27:52
Number: 07866 204849
Call type: Positive
Rating: 5
Decent Gentleman who doesn't accept any sales or marketing calls.


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text: Connect with an International Connections Academy Parent Only a parent knows the profound difference International Connections Academy makes in a child's life, so we make it easy for you to communicate directly with experienced Connections Academy parents. Choose a parent to contact based upon location, student age, or any number of interests listed under the specific parent's "Ask Me About" section. Click on Contact This Parent, to fill out the short request form, and you'll be contacted directly by the parent within a week.* * Please keep in mind that this service is provided by International Connections Academy parent volunteers and that their Learning Coach activities may prevent them from replying immediately to your request.


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Did you know that Mom's cat, Uncle Gene's dog, even your elderly neighbor's fish offer significant health benefits for their owners? It's true. Pets enhance health in oh-so-many ways.
Fifteen to 30 minutes with a pet – even watching fish – decreases cortisol, a hormone associated with stress, and increases serotonin, a chemical associated with well-being. These physical changes actually improve mood and reduce stress.
But that's not all. Compared to people without pets, pet owners have other advantages, including:
• Lower blood pressure and heart rates
• Lower levels of cholesterol and triglycerides
• Cat owners have fewer strokes.
• Heart attack patients have longer survival rates.
• Those with Alzheimers have fewer anxious outbursts.
• Those with AIDS are less likely to be depressed.
• Male pet owners have fewer signs of heart disease.
Why? Dogs need to be walked which leads to weight-bearing exercise for strong bones, heart health and contact with others along the way. Taking care of a pet creates a routine, distracts from personal aches and pains, and provides companionship. Plus pets are a great way to meet people and provide stories to swap. Pets amuse us, soothe us, make us laugh and love us unconditionally.
Given the health benefits, it's important to make every effort to keep an older adult and their pet together. If they must be separated due to hospitalization or nursing home placement, arrange for the pet's care and bring the pet to visit as often as possible. Other things to consider include:
• Ask if your loved one can still walk her dog safely. If needed, arrange for a dog walker.
• If his pet is a tripping hazard, help him know where his pet is by putting a bell on the collar.
• If her pet is too rambunctious or has bad habits, look into obedience training rather than removing the pet.
• If he has memory problems, have his pet checked by a vet. Chances are if he's forgetting his own care, he's also forgetting to care for his pet. You may need to supervise care for both.
If your loved one loses a pet, give them support and take their grieving seriously. They have just lost their companion and best friend. On the other hand, if your loved one is looking to adopt a pet:
• Select an adult animal. Their size and personality are known, they tend to be calmer, and are more likely to be content cuddling. (The local shelter is an ideal place to find a pet.)
• If she has problems with balance or stamina, consider a small dog. They need shorter walks, won't knock her over, or pull her off her feet.
• If walking is problematic, consider a cat or a very small dog that uses "puppy-pads."
• Check out assisted living homes in the area to see if they accept pets and what type. They may have weight limits that should be considered when adopting to save heartache later.
• Be sure family and friends can step in and care for the pet when needed. If not, can your loved one afford to board their pet if he is hospitalized?
• Remember when adopting that cats and small dogs live an average of 14 years. Large dogs around 8 or 9 years.
The moral is, if your loved one has a pet, don't underestimate its importance.


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In the near future, the online world decides the fate for reality. He who controls the digital controls all of humanity. In this battle for information enter Aiva, a hacking program that does battle on the information super highway, whose task is to access the enemy's mainframe and shut it down. Sp. AI is a 3rd person puzzle platformer where the player takes control of an Artificially Intelligent infiltration program called Aiva, whose abilities range from hacking systems, cracking fire walls and toying with security protocols. Game-play Pillars: 1. Seamlessly fitting puzzle that flow smoothly from on to another. 2. Real time problems that make you think on the spot. 3. Turn based strategy that makes you think 3 steps ahead. Sp.A.I Is a third year project for 5 students at the Queensland University of Technology.
Final version of the demo presented at Epic Games studio is released for download. Demo puzzles and brief game instructions included within level
sp.a.i epic demo full version
Final version 1.0 is released for download. Release includes: - minor bug fixes on level - game camera fixed
sp.a.i full version
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Performing the test is easy. After first cleaning with the supplied alcohol prep pad, the finger is lanced with the sterile disposable lancet. The hand is then turned downward and a drop of blood is placed on top of each of the four collection sticks. The sticks are then applied to the card, mixed with water, and stirred for two minutes. The results are then read from the card. Total time to results is less than six minutes.
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Drink BPA free drinks on CamelBak water bottles
Discard your temporary P.E.T. bottles and use CamelBak reusable water bottles. Now you can drink safe and pure water with CamelBak.
CamelBak was the first water-bottle company to remove BPA*** from all its water bottles, offering consumers a worry-free option in plastic water bottles. This will help people stay healthy by allowing them a convenient way to consume plenty of water.
It is important to have adequate hydration during summer and during strenuous activities; the typical CamelBak user is attuned to this and the company seeks to meet their needs.
CamelBak will continue to focus on delivering the most innovative hydration products. Until last year, polycarbonate, of which BPA is an ingredient, was included in all CamelBak bottles. CamelBak opted to eliminate polycarbonate from its bottles in response to customer demand for BPA-free products, and as of April 2008 all of CamelBak water bottle products have been made BPA-free. CamelBak's customers appreciate how the company anticipates their needs and respond quickly.
Reusable bottles are environmentally preferable to temporary plastic bottles. Temporary or disposable plastic water bottles (PET plastics) fill up landfills. CamelBak's 'Choose to Reuse' program highlights this.
Here are some tips on Hydration. For more detailed information, access Hydration 101.
- Drink early and often
- Freeze some water in your reservoir
- Keep the water out of your drinking tube
- Replace your electrolytes
- Recognize the symptoms of heat illness and get out of the sun
- Always keep water with you to all day events
Also mentioned below are some guidelines for easy cleaning and maintaining CamelBak bottles. This will keep it germ free and can use any number of time.
- Fill reservoir with warm water and mild soap.
- Clean with Reservoir Brush and Delivery Tube Brush.
- Re-fill reservoir with 1 litre of water.
- Add one cleaning tabler.
- Shake reservoir until tablet is dissolved.
- Let stand 5 minutes
- Remove water from reservoir
- Rinse reservoir thoroughly
- Re-fill for drinking or dry completely before storage
By following these above disinfecting guidelines you can reduce common micro organisms and build up over 99.99%. In an emergency, you can also add a table spoon of bleach after Step 3. Be sure to rinse thoroughly.
To know more about CamelBak products, click here.
***Polycarbonate contains a manmade chemical called bisphenol A (BPA), which leaches from the plastic at levels dramatically higher than previously thought. The chemical has been linked to breast and prostrate cancer, brain damage, and disruptions of the endocrine system. While there have been worries over BPA in water bottles for years, the evidence is now clear and compelling: You should ditch your polycarbonate bottles and use something free of BPA, such as stainless steel or a new, BPA-safe plastic called Tritan.
Dave Carr
Global Category Manager
CamelBak Products LLC
Dave Carr – A biography
Dave Carr is the Product Manager for the Bottle Category at CamelBak. He has been with the company for 3 years. Prior to holding this position, Dave was a senior engineer at CamelBak whose focus was on the full line of hydration products, including bottles and reservoirs. Dave comes from a previous position at San Diego-based Sola International Inc., a company that designs, manufactures and distributes a broad range of high-performance spectacle lenses.
Dave is a 1991 graduate of the Yale University School of Engineering and Applied Science, and lives in Napa, California. with his wife and daughter.
About CamelBak:
CamelBak has spent over a decade helping people to maximize their performance, comfort, and health by providing the highest quality drink delivery systems available. Originator of the hands-free hydration category, we focus on technically innovative, high-performance systems that fit your active lifestyle.
CamelBak is the originator and world leader in hands-free hydration system. The first CamelBak products proved to be very popular among mountain bikers and motocross riders, because it allowed them to drink without taking their hands off of the handlebars in technical terrain. The product began to cross over into other sports when scientific studies showed athletes drank more fluids and performed better when they were a CamelBak.
Since then, athletes from an ever-growing list of sports and activities use CamelBak hydration systems for their convenience and performance benefits. In addition to cycling, CamelBak has Hands-Free Hydration Systems for hiking, running, snowboarding and skiing. CamelBak's state-of-the-art packs and hydration systems have benefited athletes, outdoors men and soldiers around the world.
While CamelBak has grown tremendously since the early days, one thing hasn't changed. CamelBak still believes in the performance advantage that proper hydration delivers for just about any activity.


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PARADISE ISLAND, Bahamas (AP) Laurence Bowers had 14 points and 11 rebounds and Phil Pressey had 11 points and eight assists, leading No. 13 Missouri to a 68-65 victory over VCU on Saturday in the third-place game of the Battle 4 Atlantis.
Pressey gave the Tigers (5-1) the lead for good with a 3-pointer with 1:17 to play. That capped a run of five straight possessions where the teams exchanged the lead.
The Rams (3-3) turned the ball over with 57 seconds left. The Tigers called a timeout with 10 seconds left on the shot clock. Pressey took the inbounds, dribbled off a few seconds then made a move to the basket where he ducked under a VCU player and hit a flip shot as the shot clock hit zero.


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California Department of TransportationDate: December 15, 2011
District: 10 - Stockton
Contact: Chantel Miller
Phone: 209-941-6562
Stockton – The California Transportation Commission (CTC) today allocated $401 million in new funding to 39 projects that will help strengthen the state's economy by creating jobs and providing congestion relief for travelers statewide.
"The benefits these projects bring to California are a huge boon to the economy today," said Acting Caltrans Director Malcolm Dougherty, "and the investment in our transportation system will continue to serve travelers for generations to come."
Proposition 1B, the 2006 voter-approved transportation bond, will supply $327 million in funds to 10 projects, including $42 million toward the purchase of 42 new passenger rail cars. They will be put into service on all three state-supported Amtrak California routes – the Capitol Corridor, San Joaquin and Pacific Surfliner. This supplements $168 million from other sources, including $68 million from the American Recovery and Reinvestment Act of 2009.
To date, the state has allocated more than $11 billion in Proposition 1B funds for transportation purposes statewide.
Highlight of the funding allocations include:
- San Joaquin County: $50 million - widening 8.3 miles of State Route 99 in Manteca and San Joaquin County from four to six lanes (16.6 lane miles) between Arch Road and State Route 120. (Phase I of the project)
- Stanislaus County: $23.7 million widening of State Route 219 between Morrow Road and State Route 108. (Phase II of the project)
- Merced County: $139 million widening of State Route 99 from four to six lanes from Buchanan Hollow Road to Miles Creek overflow. Project also includes a new interchange at Arboleda Road.
Please see the attached file for more information about all projects that received allocations today.
# # # #


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...days 'til Christmas - and a just a few more Santas by Haddon Sundblom that I came across in recent days. Its kind of neat to see them chronologically like this: first from the 40's......then from the mid-50's......and finally from 1966, just ten years before Sundblom passed away.Apparently Sundblom used himself as the model for Santa in his later years, so we may be looking at a self-portrait of sorts in this piece.
Finally, an important note about a new "picture blog dedicated to Golden Age comics/pulps/classic illustration art" as David Pardee, the "curator" of Golden Age Comic Book Stories describes it. Right now David is showcasing some incredible, rare, Christmas-themed illustration including early Country Gentleman covers by N.C. Wyeth, obscure King Features booklet illustrations by Frank Godwin, Milton Caniff and Alex Raymond, beautiful Walt Disney Comics Christmas covers, and an astounding Mac Raboy Green Lama story - among many others.
Do yourself a favour and go enjoy David's generous gift - and let him know how much you appreciate his efforts!


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Appearing in a pre-taped interview on Good Morning America August 14, Sylvester Stallone, 66, spoke for the first time about his son Sage's death. The action star's filmmaker and actor son, 36, was found dead in his California home July 13.
"It's tough. It's very very tough," Sylvester said while promoting The Expendables 2. "It's a horrible situation but, time, hopefully will heal and you try to get through it. It's something that's a reality in life."
Focusing on work has helped Sylvester heal, the movie star added. "It's important to get back and try to start re-living your life. Otherwise you can go into a spiral."
Sage, who made his movie debut alongside his father in Rocky V, was one of two sons from Sylvester's first marriage to Sasha Czack. He was laid to rest July 21 at St. Martin of Tours Catholic Church in the upscale Brentwood area of Los Angeles. The cause of Sage's death is not yet known.
On August 13, Sylvester and his family — including wife Jennifer Flavin, 44, and daughters Sophia, 15, Sistine, 14, and Scarlet, 10 — attended the London premiere of The Expendables 2 sponsored by Netflix. Sylvester's son, Seargeoh, 33, was not present.
The Expendables 2 is in theaters August 17. It also stars Liam Hemsworth, 22, Jason Statham, 44, Jet Li, 49, Jean-Claude Van Damme, 51, Bruce Willis, 57, Arnold Schwarzenegger, 65, Chuck Norris, 72, Terry Crews, 44, and Dolph Lundgren, 54.
Sign up now for the Us Weekly newsletter to get breaking celebrity news, hot pics and more delivered straight to your inbox!
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Table of Contents
> Cancer chemotherapy
Cancer chemotherapy
Also listed as:
Related terms
Future research
Author information
Related Terms
Azathioprine, 5-fluorouracil, 5-FU, 6-mercaptopurine, azathriopine, cancer, chemotherapy, dihydropyrimidine dehydrogenase, irinotecan, metabolism, personalized medicine, pharmacodynamics, pharmacogenomics, pharmacokinetics, polymorphism, pharmacokinetics, SN-38, thioguanine, thiopurine S-methyltransferase, thiopurines, TPMT, UGT1A1.
Chemotherapy is the use of drugs to treat cancer. These drugs are designed to kill cancer cells by interfering with their ability to grow and reproduce. Many cancer drugs used today do not specifically attack cancer cells. This means that they not only affect cancer cells but also normal cells in the patients who take them, which is why chemotherapy drugs often produce severe side effects, including nausea, vomiting, diarrhea, hair loss, skin problems, and damage to blood and immune cells. Other types of side effects may also occur, depending upon the specific drug used.
Chemotherapy drugs, like other drugs, are absorbed by, broken down by, and eliminated from the body through a process called metabolism. Metabolism is the processing by the body of materials from outside the body. Metabolism may make a drug inactive or more active or may turn the drug into a form that can be eliminated from the body in the urine or stool. Metabolism occurs primarily in the liver and is performed by proteins called enzymes. After metabolizing a molecule, proteins in the liver then break down the molecule or attach it to "carrier" proteins that allow it to be eliminated from the body.
Proteins have many different functions within the body, including the metabolism of drugs. All proteins in the body are created based on instructions from genes. A gene is made of deoxyribonucleic acid (DNA) and serves as a map for the creation of proteins. Some parts of DNA are not genes, and do not give instructions for making proteins. These parts of the DNA control the genes and determine how active it is. A more active gene will create a more active protein, whereas a less active gene will create a less active protein. If this occurs in a gene that makes a protein involved in drug metabolism, a person may metabolize a drug more slowly or quickly than normal. This means that the drug may stay in the body for a longer or shorter period of time.
The DNA found in any two individuals is 99.9% identical, which leaves 0.1% for genetic individuality. Differences present in a gene are called alleles, or polymorphisms. These differences may result in genes that create proteins with more or less activity than others. If this happens in a gene that codes for a protein involved in drug metabolism, an individual may not be able to process a drug normally.
Differences in parts of the DNA that do not code for proteins may affect the activity of a gene. For instance, one individual may have a small difference in a part of their DNA that causes a nearby gene to become inactive. Thus, this individual will not have the protein that is created by that gene.
Proteins that metabolize drugs are called enzymes, and are created from genes. Two individuals with different alleles for the same gene may produce metabolizing proteins with different levels of activity. This means one individual may produce a protein that metabolizes drugs very quickly, while another individual may produce a protein that metabolizes drugs very slowly.
Differences in the proteins that metabolize chemotherapy drugs affect how an individual responds to the drug. They may have more or less active drug in their body depending upon what alleles they have. This means that some patients will have more effect from a drug, whereas some patients may not have any effect at all. It also means that some patients may experience more side effects than others because they have more active drug in their body. Chemotherapy drugs act on proteins within the tumor cells. Variations in genes that code for these proteins may make patients respond more or less strongly to a particular drug.
Pharmacogenomics is the study of how an individual's genes affect his or her response to drugs. This field is a combination of the study of pharmacology (drugs) and genetics and is based on the ability of researchers to identify gene variants. Gene variants can cause an individual to metabolize some types of drugs differently. This means that they may have higher levels of the drug in their body, which may allow it to be more effective or may cause serious side effects. Gene variants can be detected by several different methods, including polymerase chain reaction (PCR), fluorescence
in situ
hybridization (FISH), staining of tumor cells, and DNA microarray.
Polymerase chain reaction (PCR)
: Polymerase chain reaction (PCR) is the most commonly used method for pharmacogenomic testing because it requires a very small sample of tissue and can be performed rapidly. A small sample of cells is taken from a tumor that has been surgically removed, a blood sample, or a swab of the inside of the cheek. The genetic material is copied hundreds of times to create a larger sample. Molecules called "probes," which are DNA segments specifically designed to attach to a specific allele, are then used to tag the gene and identify it. Probes can be used to identify gene variants and to determine the amount of variant gene present in the cell. Patients with more than two gene variants may have more significant effects than patients with one gene variant. This method can be used to detect variations in genes that process and inactivate drugs in the liver.
in situ
hybridization (FISH)
: Fluorescence
in situ
hybridization (FISH) is a method that is used to determine whether a specific part of a chromosome is present in a cell. This is useful because in some types of genetic variations there are additional copies of a certain chromosome or there are gene variants on a chromosome that are abnormal. To perform FISH, researchers first identify a specific region of a chromosome (for example, a region that contains a specific gene). They then generate a probe or a sequence of DNA that can recognize and bind to the chromosomal region of interest. In FISH, the probes that researchers use fluoresce, that is, they glow under ultraviolet light if the labeled chromosomal region is present.
In some diseases, such as cancer, genetic mutations occur that can cause part of a chromosome to be deleted, repeated, or reversed in orientation. By looking for differences in how chromosomes from different cells stain with a probe, researchers may be able to observe these changes under the microscope and learn more about the genetic mutations that cause a particular disease.
Tissue staining
: Tissue staining is an indirect method of detecting gene variants and is usually used on tissue that has been surgically removed, such as a tumor. Stains are created that specifically attach to one gene variant or to the protein it produces. The stain is applied to a sample of tumor and is examined under the microscope. If the gene variant is present, then the protein will also be present and the stain will be positive. This method is used to detect the presence of gene variants in some types of cancers.
DNA microarray
: DNA microarray is a method of studying multiple genes at a single time. Microarrays are used to detect changes in dozens, hundreds, or thousands of genes and can therefore provide more information about a person's specific genetic makeup. As a result of microarrays being a relatively new technology, they are primarily used in research. Microarrays use probes that detect a specific gene variant, and determine the amount of variant gene present in the cell.
: Pharmacogenomics is the study of how an individual's genes affect his or her response to drugs. It is a combination of the study of pharmacology (drugs) and genetics. Pharmacogenomics is based on the ability of researchers to identify gene variants. If scientists know that a gene variant causes a patient to respond to a drug in a certain way, doctors may decide not to prescribe that drug to the patient.
Application of pharmacogenomics to chemotherapy includes testing patients to determine whether they have gene alleles that may cause them to benefit from the anticancer effects of the drug or that may cause them to have severe side effects. Chemotherapy drugs affected by genetic variations include thiopurines, 5-fluorouracil, and irinotecan.
: Thiopurines are a type of drug that prevents cells from reproducing by inhibiting DNA synthesis. This class of drug includes 6-mercaptopurine, thioguanine, and azathioprine. 6-Mercaptopurine and thioguanine are used to treat some types of leukemia. Azathioprine is used to treat rheumatoid arthritis and patients who have had a kidney transplant. These drugs are in an inactive state when they enter the body. They are activated by the metabolic process involving several enzymes, including hypoxanthine phosphoribosyl transferase. Thiopurines are inactivated in the body by two enzymes: xanthine oxidase and thiopurine S-methyltransferase (TPMT).
Polymorphisms in the gene for TPMT cause some people to metabolize thiopurines slower than others. About 90% of Caucasians have high activity of TPMT, 10% have intermediate activity, and 0.3% have little or no activity. The rates of allele variations in other racial groups are uncertain.
Patients with one variant allele have intermediate activity of TPMT, and they are at an increased risk of having severe side effects when treated with thiopurines. The most common side effects are nausea, vomiting, and fatigue. Serious possible side effects include liver damage, bone marrow suppression, infection, and a secondary cancer. Patients with two variant alleles have very little or no activity of TPMT, and they are at a very high risk of having severe, life-threatening side effects with thiopurines. Testing for TPMT variant alleles can detect these patients and allow doctors to adjust the drug dosing or not use the drug at all.
5-Fluorouracil (5-FU)
: 5-Fluorouracil (5-FU) is used to treat colon, breast, and head and neck cancers. It is inactive when injected, and must be metabolized in the liver to its active form in order to kill tumor cells. 5-FU kills tumor cells by blocking a protein called thymidylate synthase, which helps tumor cells divide and reproduce. It is inactivated by a protein in the liver and blood called dihydropyrimidine dehydrogenase (DPD).
A region of DNA that controls the action of the thymidylate synthase gene, called a promotor, has polymorphisms that are seen in different people. Some polymorphisms cause the thymidylate synthase gene to be more or less active and to produce more or less protein.
Patients who have a gene variant that causes the gene to be less active, and therefore to produce less protein, metabolize 5-FU more slowly than normal. This means they have higher activity of the drug in their body and that 5-FU is more effective in controlling their cancer. However, patients with this gene variant are also more likely to have severe side effects from 5-FU, such as bone marrow suppression and heart and liver damage. Testing for variants in the thymidylate synthase gene promoter is not performed regularly in patients receiving 5-FU because this testing has not been studied in large human trials.
Dihydropyrimidine dehydrogenase (DPD), the protein responsible for inactivating 5-FU, is present in varying amounts in the blood. Some people have very low levels, which results in an inability to adequately inactivate 5-FU. These patients have a high risk of serious and potentially fatal side effects, including heart and liver damage and bone marrow suppression.
The gene variants that cause differences in the amount of DPD activity are not well understood. Many different variants exist, and the effect of each variant on DPD is not yet known. It is therefore not currently possible to test for DPD gene variants.
: Irinotecan is used in the treatment of colon cancer. Irinotecan is inactive when it is administered to the patient but is converted to its active form, called SN-38, within the body. It is inactivated by a protein in the liver called UDP-glucuronosyltransferase 1A1 (UGT1A1).
The activity of the gene that produces UGT1A1 is controlled by a part of DNA called a promoter. Polymorphisms in this promoter result in less activity of the gene and less UGT1A1 protein. With less of this protein, patients have higher levels of the active drug SN-38 and are at a higher risk of having severe side effects, including diarrhea and suppression of the immune system.
A test for UGT1A1 gene variants is available and allows doctors to detect patients who are at high risk of severe side effects. Doctors may choose to use a lower dose of irinotecan or a different drug in these patients.
Safer, more effective chemotherapy
: By determining gene variants that affect the way patients respond to chemotherapy, it may be possible to test patients prior to beginning therapy to determine whether they will benefit from the drug or are at high risk of severe side effects. Patients with genetic variants that cause them to receive no benefit from a drug, or to have severe side effects, can be given a different chemotherapy drug that will be safer and more effective.
Targeted therapies
: Drug companies have recently started to develop drugs that act on a single gene or protein. These drugs are called targeted therapies because they are designed to act on a specific target within the cell. Pharmacogenomic testing is used to identify patients who will benefit from the drug. For instance, Herceptin®, a drug used to treat breast cancer, acts on a specific gene variant that occurs when tumor cells produce too much of a gene called Her2/neu. Herceptin® works only in patients who are positive for this variant. Genetic tests are performed on patients before Herceptin® is prescribed.
The genes involved in the metabolism and action of many chemotherapy drugs are unknown. Much research is required to detect these genes and their variants before clinical tests can be developed. This requires significant time, human resources, and financial investments.
Future research
Research is being done on currently available chemotherapy drugs to determine whether gene variants are responsible for the differences in effects observed among patients. If genetic variants are responsible for the different responses, pharmacogenomic tests may be used before using chemotherapy to determine who will actually benefit from the drug.
Author information
This information has been edited and peer-reviewed by contributors to the Natural Standard Research Collaboration (www.naturalstandard.com).
Abraham J, Earl HM, Pharoah PD, et al. Pharmacogenetics of cancer chemotherapy. Biochimica et Biophysica Acta. 1766(2):168-83, 2006.
American Medical Association. Pharmacogenomics. .
Candelaria M, Taja-Chayeb L, Arce-Salinas C, et al. Genetic determinants of cancer drug efficacy and toxicity: practical considerations and perspectives. Anti-Cancer Drugs. 16(9):923-33, 2005.
Damaraju VL, Damaraju S, Young JD, et al. Nucleoside anticancer drugs: the role of nucleoside transporters in resistance to cancer chemotherapy. Oncogene. 22(47):7524-36, 2003.
Gusella M, Padrini R. G>C SNP of thymidylate synthase with respect to colorectal cancer. Pharmacogenomics. 8(8):985-96, 2007.
Marsh S. Thymidylate synthase pharmacogenetics. Investigational New Drugs. 23(6):533-7, 2005.
Miller CR, McLeod HL. Pharmacogenomics of chemotherapy-induced toxicity. J Support Oncol. 2007 Jan;5(1):9-14.
National Center for Biotechnology Information. One Size Does Not Fit All: The Promise of Pharmacogenomics. .
Natural Standard: The Authority on Integrative Medicine. .
Weinshilboum R, Wang L. Pharmacogenetics and pharmacogenomics: development, science and translation. Annu Rev Genomics Hum Genet. 2006;7:223-45.
Xia CQ, Yang JJ, Gan LS. Breast cancer resistance protein in pharmacokinetics and drug-drug interactions. Expert Opinion On Drug Metabolism & Toxicology. 1(4):595-611, 2005.
Zhang X, Diasio, RB. Regulation of human dihydropyrimidine dehydrogenase: implications in the pharmacogenetics of 5-FU-based chemotherapy. Pharmacogenomics. 8(3):257-65, 2007.
Copyright © 2011 Natural Standard (
The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.
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text:
Until recently, Internet service providers (ISPs) were just that: a bare-bones channel through which the Web flowed to customers.
They were stuck manning the Internet spigot as Google and Microsoft lapped up the profits from incredibly successful targeted ads. Every time users type in search terms or read letters in Gmail, the company learns a little more about what ads might appeal to them. Online social networks such as Facebook have also cashed in on direct marketing by picking up keywords in user profiles.
But now, many ISPs want in on targeted advertisements. From their perspective, they are the best source for user data. Google can only track what users do on its sites. But since ISPs control the flow, they can monitor everything a customer does online.
It's the marketing mother lode, but this shift in business practices worries some privacy advocates.
"There is a definite push for more data collection," says Alissa Cooper, chief computer scientist at the Center for Democracy and Technology. "[ISPs can also] collect your search terms. They claim they limit that. We haven't done independent research, but if you look at the capabilities of their devices, they're certainly capable of looking at other types of traffic."
Ms. Cooper's colleagues take up this issue in a Senate Commerce Committee hearing this week. After a recent scandal where British Telecom reportedly tracked user data without alerting its customers, Congress wants to iron out what American ISPs are allowed to monitor and how much they need to disclose.
Already, 70 percent of Web users are aware that their Internet footsteps may be tracked for advertising, according to a TrustE survey cited by CNET. Yet just 23 percent are comfortable with such online tracking, even if companies agree not to share the information.
Even if Web users accept some online snooping, few expect ISPs to be the culprits, says Wendy Seltzer, a follow at Harvard University's Berkman Center for Internet and Society.
"There is a difference between going to a site that you know will be including advertising and going to an ISP who you expect to be a simple carrier," she says. People can easily choose whether or not to use Google sites, but it's much more difficult to switch ISPs.
In many cases, these ISP targeted ad initiatives are "opt-out," meaning that the company automatically enrolls users. If people want out, they have to ask to be removed.
While European activists and legislators are up in arms about British Telecom's questionable definition of user rights, legal professionals say laws in the United States are much less restrictive.
The European Union explicitly requires an "opt-in" on the part of users, so British Telecom likely will have to change their policy. Not so for American ISPs.
The US has "a very market-driven, capitalistic approach," says Leslie Reis of the Center for Internet Technology and Privacy Law at the John Marshal Law School in Chicago. "The US takes a mishmash approach to privacy. There are a lot of interests and a lot of lobbyists on the commercial side involved."
Part of the reason the rules are so murky is that the Privacy Act of 1984, the go-to law for Internet users' privacy, has not adapted to the rapidly changing face of the Internet, according to Professor Reis.
"Other than one amendment that dealt with data mining, there have been no changes to this law," she says. "This is a huge problem. The legislation was created when the Internet was a gleam in certain scientists' eyes."
One solution: Companies can explain their privacy policies, usually as part of an "end user license agreement," which are those long blocks of text that people often see when they install a new computer program. While this is legally kosher, few actually read the fine print. That's not always a good thing for companies. In some circumstances, websites have found it to be in their own interests to be transparent.
Last year, Facebook created a stir with Beacon, the part of its ad system that delivered social-network features to nonsocial sites. This allows a user to share her Web activity with friends across the Internet – and possibly with advertisers as well.
In November, several online privacy groups banded together to demand that Facebook not share any Beacon information without the user's explicit consent. The company quickly reached out, explained how the new feature works, and retooled Beacon to ease privacy concerns.
Unfortunately, ISPs don't necessarily have the same incentive to educate their customers. There's far more competition between social-network sites than there is in the ISP market, says Ms. Seltzer. Signing up for a new service provider can take days, and some communities only have one ISP.
While the disincentive of restricting the market for targeted ads is present, Seltzer argues that regulation and the strength of the market are not diametrically opposed.
"Regulation creates a framework for the targeted advertising business model to operate in," she says. "Regulation that preserves the Internet's openness allows the many Web markets to flourish. It's not regulation versus market, it's regulation for the market."


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William Woods University Athletics Department is excited to announce that varsity men's and women's tennis will return to WWU, and competitive play will begin in the fall of 2015.
William Woods had women's tennis teams from 1976 to 1999, but 2015 will be the inaugural season for men.
"We are eager to add two additional varsity sports to the William Woods athletics department," said Director of Athletics Jason Vittone. "We are confident the sport of tennis is a great fit for our university and department. We are eager to start a search for our tennis coach and begin the recruiting process."
One coach will be in charge of both the men's and women's tennis programs, starting in August 2014. During the 2014-15 academic year, the coach will recruit and the tennis courts will be resurfaced in preparation for the fall 2015 season.
In the American Midwest Conference (AMC), Missouri Baptist, Lindenwood-Belleville, St. Louis College of Pharmacy and Stephens College sponsor women's teams. Of those, all but Stephens have men's tennis teams.
"Currently the AMC competes in an unaffiliated grouping to qualify for the national tournament," said Vittone. "The conference needs six member institutions to receive an automatic bid. With William Woods adding tennis, it gets our conference one step closer to that goal."
WWU athletics is coming off an outstanding 2013-14 season, with the university collecting 10 AMC Championships; qualifying six teams and eight individuals for Nationals; achieving an athletic department grade-point average above a 3 point; and recognizing 27 NAIA Scholar-Athletes, eight NAIA Scholar-Teams, 109 AMC Academic All-Conference recipients, 83 All-AMC honorees and 19 NAIA All-Americans.


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If you're lucky enough to get any snowfall, go through the Carmel tunnel and check out the eastside. It's easy to wander around there and a completely different landscape than the canyon. The petrified dunes are very pretty covered in ice and snow.Phillip
I turned back from the final slope to Angel's Landing - it was downright scary without crampons and I'm surprised that only 6 people have died there since 2001.
The classic shot down the Virgin River from the bridge looks quite good with snow in the winter.It is shown below in the first week of November.


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Summer Flora 2011
Summer Session I
June 1st to July 8th
M/W/F 1:00 pm to 5:00 pm
Nicholas Tippery (email@example.com)
Contact me for a permission number
Course description
New England is home to a diverse and thriving selection of plants, many of which reach their peak exuberance during the summer. Proper identification of plants and an understanding of their interactions with the environment are important facets that aid in the appreciation of our natural resources. In this course, students will:
- Learn to recognize by sight some of the more common plant species
- Develop a skill set for identifying unknown plant species
- Gain experience in plant census, collection and curation techniques
- Learn the system of classifying plant diversity and of naming plant species
- Learn about the diversity of plant habitats in New England
The course focuses primarily on plant identification and classification, but students also will acquire skills that would serve them in any number of careers dealing with natural resource management.
Required equipment (all available from UConn Co-op)
- 10x hand lens
- field notebook
- pencils
Texts under consideration
- L. Newcomb. 1989. Newcomb's Wildflower Guide. ISBN: 0316604429.
- H. A. Gleason and A. Cronquist. 1991. Manual of Vascular Plants of Northeastern America and Adjacent Canada. ISBN: 0893273651
(**illustrations are a separate book:
N. H. Holmgren, P. K. Holmgren, and H. A. Gleason. 1998. Illustrated Companion to Gleason and Cronquist's Manual: Illustrations of the Vascular Plants of Northeastern United States and Adjacent Canada. ISBN: 0893273996)
- J. G. Harris and M. W. Harris. 2001. Plant Identification Terminology. ISBN: 0964022168
- D. W. Magee and H. E. Ahles. 2007. Flora of the Northeast. ISBN: 1558495770
(1999 edition ISBN: 1558491899)
Student plant collection: 25%
Exam 1: 30%
Exam 2: 35%
Assignments and Quizzes: 10%
Tentative schedule
|Week 1
|Wed., June 1st
|Introduction to course
|Reproductive features
|Campus walk
|Fri., June 3rd
|Plant identification using keys and other resources
|Vegetative features
|Campus walk
|Week 2
|Mon., June 6th
|Plant nomenclature and taxonomy
|Fern terminology
|Wolf Rock
|**Last date to add/drop
|Wed., June 8th
|Fern identification
|Webster Fern Garden, Pink Ravine
|Fri., June 10th
|Phylogenetics and Systematics
|Gymnosperm identification
|Mansfield Hollow S.P.
|Week 3
|Mon., June 13th
|Trees and shrubs
|Brassicaceae / Ranunculaceae / Rosaceae
|Boston Hollow
|Wed., June 15th
|Moss identification
|Room available for review after class
|Fri., June 17th
|Lamiaceae / Plantaginaceae / Scrophulariaceae
|UConn Forest - student collection 1
|Week 4
|Mon., June 20th
|Natural History collections
|Tour UConn Herbarium
|Identification of student collection 1
|Wed., June 22th
|Plant and animal interactions
|Goodwin S.F.
|Fri., June 24th
|Invasive species and species of conservation concern
|Apiaceae / Asteraceae / Fabaceae
|UConn Forest - student collection 2
|Week 5
|Mon., June 27th
|Graminoid (grass / sedge / rush) identification
|Cyperaceae / Juncaceae / Poaceae
|Identification of student collection 2
|Wed., June 29th
|Ecological survey techniques
|Fenton River
|Fri., July 1st
|Aquatic plants
|Amaranthaceae (incl. Chenopodiaceae) / Ericaceae / Polygonaceae
|Bigelow Hollow S.P.
|Week 6
|Mon., July 4th
|NO CLASS - Independence Day
|Wed., July 6th
|Collection notebook due
| Student collections due (dry!) /
Collection labels due (electronic document)
|Hammonasset S.P.
|Room available for review after class
|Fri., July 8th
|Specimen mounting