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Results 1 to 9 of 9
#1 Florida Man, 32, Dies Shortly After Winning Pet Store's Roach Eating Contest10-08-2012, 11:57 PM
A Florida man died Friday night after consuming "dozens of roaches and worms" during a contest held by a pet store, police report.
Edward Archbold, 32, collapsed after winning the repulsive contest at Ben Siegel Reptile Store. Archbold, who was competing for a free python, was stricken outside the Deerfield Beach business, according to the Broward County Sheriff's Office.
Investigators reported that Archbold "wasnt feeling well and began to regurgitate" shortly after the contest's conclusion. "He had consumed dozens of roaches and worms," a sheriffs spokesman noted.
Archbold was pronounced dead after being transported to an area hospital. An autopsy was conducted, and the Broward County medical examiner is awaiting test results to determined Archbold's cause of death.
Archbold is pictured above in a mug shot taken in 2004, following his arrest for disorderly conduct and indecent exposure (for which he was convicted).
The roach eating contest was part of the reptile store's October 5 "Midnight Madness" sale. Contestants had four minutes to devour the most discoid roaches, which can grow up to three inches long. "Oh yeah, any vomiting is an automatic DQ," the store cautioned in a Facebook post prior to the revolting competition.
Another promotional piece referred to the upcoming event as "the soon to be infamous 'Eat Bugs For Balls Contest.'" The python for which Archbold competed is known to curl up into a ball as a defensive reaction.
In a Facebook update yesterday, the store stated that, "Although we just met Eddie the night of the sale, we all liked him right away. All of us here at Ben Siegel Reptiles are sad that we will not get to know Eddie better, for in the short time we knew him, he was very well liked by all."
Asked about the python won by Archbold, the store reported on its Facebook page that, "The snake is being held in his name and is full property of his estate."
http://www.thesmokinggun.com/buster/...roaches-587314"If the Bible is true why don't we have any urns or vessels that like say expires 6/15/300 BC on the bottom?"
Alexandria Ocasio Cortez
They weren't deep-fried??It's not how old you are, it's how you got here.
It's been a long road and not all of it was paved.
. If you ain't havin' fun, it's your own damn fault
- Join Date
- Mar 2010
- Posts
- 3,269
Speaking of sick and weird..
Yesterday my son in law gave birth to a botfly maggot. He had what we all thought was a boil or abscess on his arm. But we were all on vacation in Florida, so he just stayed out of the water because it was weeping. Yesterday morning he went to change the dressing and came down to report that a lump had formed and was bulging out of the skin. One of the women is a nurse, so she went over to look.
She didn't know what it was but said she was sure it had to come out so the wound could be cleaned. Paper towel, a little squeeze, and out pops a maggot, which as far as maggots go, was huge. About 1/2 inch long. wiggling around on the counter.
We saved it, looked it up, and identified it as a botfly, which makes sense because he just got back from a trip to Africa about 3 weeks ago. He won't be going back.
- Join Date
- Mar 2010
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- 10,189
I saw a movie once where this girl escapes from someone into the jungle in South America. She has a terrible time, and is then found by some kind of guerilla soldiers who take her to their camp. After resting a bit, she breaks into a screaming fit digging at her back. The guerillas know what they problem is, and one holds her down while the other one washes her back with gasoline, which causes these nasty worms to come up through her skin. The special effects are pretty well done, and the removal of the worms is disgusting.While you were hanging yourself , on someone else's words
Dying to believe in what you heard
I was staring straight into the shining sun
I wondering why someone in south Florida would do all that for a python. All he needed to do was go in to the Everglades and catch one. It probably about as safe as eating roaches.
Last edited by FlaGator; 10-09-2012 at 10:01 AM.Cast your burden on the Lord,
and he will sustain you;
he will never permit
the righteous to be moved.
Psalm 55:22
I know I'm a big government liberal and everything, but there really should be a law against a contest like that. There probably is a law against it in most states.
I wonder if they still get kids to swallow live goldfish at Young Life club meetings, or if that practice has been banned. Although, that is probably safer than eating cockroaches.
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I wonder if the Darwin Awards will get a hold of this.
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Krematorium V
Krematorium V's
gas chambers had four rooms, which are just over the low brick wall and
Scrolling past it you can see in the distance the ruins of Krematorium IV, and to its right, The Sauna. As you continue scrolling, you see a field reaching to the far corner, and four memorial stones. Just to their left and past the shaded area is where the burning pits for the Krematorium were located. The problem for the Nazis was not how many people they could gas, but how to dispose of all the corpses. At peak periods such as the Hungarian "Aktion" (May-June 1944), these pits greatly increased disposal capacity. First, a layer of wood was placed in the pit, next a layer of corpses, finally petrol waste was poured over the bodies, and the layering repeated a second time. Trenches were dug in the sides to catch the fat run-off, as throwing it back on the flames made them even hotter.

subset: commoncrawl


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Accounts Payable – FAQ
Frequently Asked Questions
A: It is College policy to pay only for institutional membership dues. This policy is based on the Attorney General Opinion 68-110. There are some possible exceptions, and include:
– Transferable individual memberships
– Memberships that are required as a condition of employment
– Memberships that are required for accreditation of a department or program
– The membership fee plus a registration fee to an organization's conference is less than the nonmember registration
– The membership results in a discount on beneficial publications that is greater than the cost of the membership
A: All original invoices or credit memos received in any university department need to be IMMEDIATELY forwarded to Accounts Payable in the Office of Fiscal Affairs.
A: The processing time required for all payments is dependent on the time the request is received in Accounts Payable. Check requests (with all appropriate documentation and signatures) will be processed in five working days.
*Please note that payment on check requests submitted without appropriate documentation will be delayed until the requested documents are received. Payments may also be delayed on occasion due to end of year processing, training of new hires, absences or system failure. Be sure to plan accordingly and submit your check request as soon as invoices are received.
*Please remember to advise your vendors of this policy when conveying payment information to them.
A: Checks are normally mailed to vendors. Checks may be picked up in the Accounts Payable Office when a check needs to be hand delivered.
A: Sending checks through campus mail presents a security risk, therefore, all checks are to be mailed or picked up on the Floyd Campus by an employee of GHC.
A: State policies require original, detailed, signed and dated receipts showing the invoice date and amount to be paid.
Note, statements only are not sufficient back up and will not be accepted as sole backup. Please request a copy of the invoice from the vendor even if it is a past due invoice.
A: Yes. When travel expenses are being reimbursed to students or other non-employees, they are expected to remain within the per diem rates.
A: You should submit a sales tax exempt form at the time the order is placed.
A: These numbers allow a more thorough search of the vendor database for existing vendors. For example, if a vendor has a parent company but 'does business as' a subsidiary name. Another example would be if a vendor's name changes due to a life event or sale of the company. This information is also pertinent to the set up of 1099 information within the vendors file. An easy way to request this information is to ask the vendor for a W-9.
A: Employees of GHC receiving monies for services above and beyond their normal salary cannot be paid through AP. They must be paid through payroll. Please contact GHC's Payroll Office for instructions on how to submit this expense for payment.
If the vendor is employed at another unit, that unit must invoice us and we will pay that unit through AP. The invoicing unit will in turn pay their employee through their payroll system.
A: Fill out a check request made payable to the hotel for the exact amount of your lodging. Be sure to obtain a confirmation from the hotel showing your confirmation number and amount. Submit the confirmation, a list of attendees/room assignments and a meeting brochure with your check request. Be sure to retain a copy for your records and to take with you in case of discrepancies.
A: Contact the AP department with as much detailed information about the vendor and payment as possible. This will assist our department in looking up the vendor payment history. We will contact the bank and if the check has cleared a copy of the canceled check (front and back) will be emailed to the requestor along with the date the check cleared.


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Cupcake: I called St. John's today and was informed that my file was being held for possible admission into a Summer Institute that they are offering. She told me that they wouldn't make a decision until the end of the month. Maybe that's the case with your file. I don't know why they didn't let people know that in the first place. Thanks for the advice about Newark. I have heard that it was a bad area from several people. I am looking to stay in Jersey City if I move there. Hoboken is too expensive for me. I still have more options to weigh but I gave myself a deadline of April 30. Are you any closer to a decision?
I also applied to St. John's in December and still haven't heard, so I'm sending in my Seton Hall deposit today. I really liked the feel of the campus, and the improved rankings certainly made me more comfortable with it. I'm from Chicago and know nothing about New Jersey, so I was planning on living in Eleven80 or the Union Building- but anyone who can offer a better idea of where to live would be greatly appreciated (how far are Jersey City/Hoboken from Newark- are they on the PATH?).


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Simply slide this unique product over a mugul base socket on most horizontal burning reflectors to filter & disperse the intense hot spot of light directly under an HID lamp. With the hot spot diffused, you can hang reflectors closer to the plant canopy while reducing the risk of burning the plants directly under the lamp.
The revolutionary shape, size and hole patterns were designed using the latest lighting development software. The Equalizer will aid in improving the uniformity of your fixture by reducing the hot spot below the lamp.
— Ships from H: WA, CA, CO, MI, TN, PA, FL USA.


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The code: http://hastebin.com/fivudaraje.coffee
When trying to run this script - the program crashes. When I ommit the inserting to the 9th child element it works fine. That tells me - that adding new subitem only works on the last created child to the root node. Is that expected behavior and I just missed to realise it? But how can I add a subitem to, let say, the 5th root element or the 9th like in the example?
Please give me a hint what I'm missing here!
greets Charlie!


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1 Comment
'Meet The Fockers' Star Teri Polo Tells Us She Wants To Pose For 'Playboy' Again!
Senior Entertainment Reporter
You probably recognize Teri from her role as Pam in 'Meet The Parents,' but she's nothing like her uptight character!
Teri Polo loves being naked! The 41-year-old actress posed for Playboy in 2005 when Meet the Parents first hit theaters, and now she wants to do it again! HollywoodLife.com spoke with Teri on Dec. 15 at the NYC premiere of Little Fockers, and she revealed she's ready to strip down if Hugh Hefner gives her the call!
"Absolutely, for sure," Teri told us of getting back in front of the Playboy lens. "It was one of the best experiences of my life. I'm very proud. We shouldn't be ashamed of the human body. The human body is beautiful, and it's a shame we put such a taboo on certain things. Why be ashamed? It's such a beautiful thing."
HollywoodLifers, do YOU want to see Teri in the pages of Playboy again? Tell us!


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Auto major Toyota Kirloskar Motor on Thursday unveiled its first crossover, 'New Etios Cross', targetting young customers.
Available in 1.5 and 1.2 litre petrol engines and a 1.4 litre diesel engine, the crossover would be launched in May this year but the company has already started taking bookings.
The price of the model, which has the design appeal of an SUV, will be revealed in May.
FULL COVERAGE:Auto Expo 2014
Crossover vehicles are built on a car platform but combines some of features of a sports utility vehicle (SUV).
When asked about the likely price of the new model, TKM Deputy Managing Director Sandeep Singh said that it would cost more than the existing Etios Liva series.
Etios Liva models are available in the range of Rs 4.23-Rs 7.12 lakh (ex-showroom, Delhi).
The new model, available in eight colours, will expand the car maker's Etios series with existing models -- the Etios, the Liva and the Liva 1.5 TRD Sportivo.
The crossover is launched targetting consumers in the age segment of 25-35 years, Singh said at the 12th Auto Expo here.
The model is targetting a whole new breed of audience who seek uniqueness and individuality in everything they do, Toyota Motor Company Chief Engineer Akio Nishimura said.


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Consumers are ready to invest in their fitness again, according to the Sporting Goods Manufacturers Association's (SGMA) State of the Industry Report for 2011.
In an online survey of more than 38,000 people conducted for SGMA by Sports Marketing Surveys, 36 percent of respondents said they planned to spend more in joining or rejoining health clubs over the next 12 months. The figure is up 23 percent from last year.
The authors of the SGMA report conjectured that the expected boost could be the result of pent-up demand due to reduced spending on sports, fitness and recreation in 2010. Twenty-two percent of survey respondents said they had reduced their expenditures on things such as health club memberships and fitness or sports instruction in the previous year. Another 15 percent said they had delayed spending in those areas altogether.
The report also gave some insight to what fitness activities could be most popular as more people join and rejoin health clubs. Using a variety of market data, SGMA researchers predicted the growth potential for 20 sports and fitness activities. Of traditional club-centered activities, squash and yoga showed the greatest potential for growth, with projected rises of 52 percent and 42 percent, respectively, by 2015. High impact (35 percent) and step (33 percent) aerobics, running (31 percent), cardio kickboxing (26 percent) and group stationary cycling (22 percent) rounded out the list.
Clubs that want to attract members that are new to exercise may want to invest in their aquatic facilities and programming, according to the report. Responding to a question about what activities in which they would be most likely to participate, swimming ranked in the top three for all age groups of those who described themselves as currently inactive. Other top "aspirational activities" included weight training, working out using machines and cycling.
Sales of fitness equipment show that facilities are preparing for their new and returning members. After a dip from $1.041 billion in 2008 to $970 million in 2009, institutional fitness equipment sales rose to $1.023 billion in 2010.


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This Beverly Boulevard farm to table operation opened last year. I stopped by for brunch on a Saturday, and the pastries alone were worth the trip. The pastry basket isn't actually a basket; it's a tray, but the day I went it came with a fresh jelly doughnut, a blueberry muffin, a cheese biscuit and a ginger scone. These were all excellent, but the scone impressed me the most. Never have I had a scone that was so flaky, so melt in the mouth delicious. The doughnut was slightly larger than a golf ball and stuffed with a thick, nicely tart strawberry rhubarb jam.
The baked goods also shined as part of the breakfast entrees. The baked pancake is a unique and delicious beast, a puffy pancake with crisp edges and a light and fluffy center emphasizing the "cake" in pancake.
The house made bagel was delicious, though a bit hard on the outside, but the smoked trout it was served with was bland.
Overall, the sweet outshined the savory, but most everything was good. I went back for lunch, and definitely enjoyed it, but nothing was quite as great as their various brunch pastries.
Cook's County
8009 Beverly Blvd.
Los Angeles, CA 90048


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Amy Svitak writes:
Aviation Week & Space Technology: When does SpaceX plan to launch the SES-8 mission?
SpaceX President Gwynne Shotwell: Mid next-year. It's July some time, I just don't know the date.
AWST: What is the status of development of Falcon 9 v1.1's payload fairing and when will it fly?
GS: The design is done, the first unit is built and we will start testing in the next month or so. I've got to fly it in at least Q2 next year, for [Canada's] Cassiope.
AWST: Where is SpaceX in terms of testing the more powerful Merlin 1D engine?
GS: We're in qualification testing on Merlin 1D, we'll be testing that engine through the end of the year. Whenever we fly [an] engine, we've got thousands and thousands of seconds on it, and we want to make sure we do the same here. But that engine is doing a qual run right now.
AWST: When do you plan to complete work on modifications to the launch site at the Cape?
GS: The major upgrades are, well, we'll be building a heavy [lift launch vehicle] site there and we are upgrading the launch platform to accommodate the new version of the Falcon 9. So it's more tankage, probably more pumps. We're always innovating to increase our rapidity, our pace of launch as well.
AWST: What about your new payload processing facility there -- are you going to put Astrotech out of business?
GS: I don't have any intention of putting anyone -- well, I don't have any intention of putting Astrotech out of business. They have a loyal following, we just want to make sure we can offer a service for our customers. We are building a facility that can launch our commitments and provide the fueling. They've got more chambers, more spaces than I have, so I don't want to say they're comparable.
AWST: Why the octagonal arrangement on the engines on the upgrade?
GS: As opposed to the tic-tac-toe? You actually want the engines around the perimeter at the tank, otherwise you're carrying that load from those engines that aren't on the skin, you've got to carry them out to the skin, cause that's the primary load path for the launch vehicle. So you really want those engines out on the skin anyhow.
AWST: Why wasn't that done initially?
GS: Well, we learned a lot of stuff [with Falcon 9].
AWST: As a percentage, how much difference is there between Falcon 9 and Falcon 9 v.1.1?
GS: It's the same tank architecture, it's the same fundamental process on the interstage, I believe it's the same evolved subsystem. The engines are largely the same. Even though its more thrust, the chamber geometry is the same. The chamber itself is the same, the difference is instead of plating it, we're brazing on jackets. The nozzle is different. We use a tube wall nozzle on the [Merlin] 1C and we're using the milled copper for the nozzle extension. It's a much higher thrust engine but surprisingly a lot of the infrastructure of that engine is the same.


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Quote from: jack on May 06, 2009, 12:21:36 PMRegistration Hotel 9-6Need to have 3-4 people at all timesPencil me in for a slot at the reg table on Sunday.I'd volunteer at the hotel on Saturday too, but detail work at Wyco may run over from Friday.
Registration Hotel 9-6Need to have 3-4 people at all times
Ag Hall of Fame....
Welcoming committee--Things to do in KC, give ideas of what is fun and directions if needed.
Quote from: Tracy on May 13, 2009, 11:11:03 AMFor the folk who are suggesting things to do in the KC area, are you volunteering for Welcoming Committee duty?It's so nice to know that any ideas outside of the "Committee's" are not welcome. Saves me from trying to help in any way! Thanks for the heads up Jack and Tracy.
For the folk who are suggesting things to do in the KC area, are you volunteering for Welcoming Committee duty?
Please only reply if you plan on helping, I don't what these to turn into what to do threads, you can either help or not. If you want to help, acknowledge and help, don't post in here what you want others to do, that is not what this is for, get with Becky and work on it from there, this is not where the work will be done, but rather who will do the work. So I will put CD and Andy down as helpers for all day Sunday.Thanks,Jack
I will be available both sat and sun.I think Chappie has me at the distance comp but not sure.


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Wednesday, February 24, 2010
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great beard style!
Loving the Oliver Peoples translucent specs! fleet street personified!
Ok The beard is a tad long and bushy for me and I usually like facial hair on a man. Otherwise I love the colours and isn't his hand pose so genteel!
Isn't is Somerset House??
Well, he certainly has guts and a good self-esteem.
The colour of the shoes is perfect, though.
Cheers, San
I love it! Very "1950's university professor".
hey sart, love the shot, the blazer reminds of luca rubinacci. just a heads up on the title, its called 'somerset' house!
First Pic In The Morning..
Nice Shoes..!!
The boots, the boots! And russet! A slim bit of color is music.
Sorry - hate it. Looks like a hobo. I get the individual look but this doesn't cut it.
Lol fantastic outfit! Love those boots!
what a beard!!! I love it! and those shoes, pants and colours... if i d be a man, i would like to be him!
Love the orange color on this guy !
And the street is sooooo beautiful !
Haha - Go you!! And even I got the spelling wrong being such a smart ass! xxo
I can't be wrong! He must be the reincarnation of JOHN RUSKIN and his "Stones of London" - adorable le look, adorable les couleurs, voilà connoisseurship at its best -
The shot is good but the style does not quite cut it for me. It is too much, he looks like he is trying too hard to be 'fashionable-while-not-looking-fashionable, edgy-but-not-looking-too-edgy, old-style-but with-a-modern-twist'.
Most importantly, everyone needs to dress according to their bodies. If the latest fashion does not suit your body, don't follow it. (The other option is to do like Karl Lagerfeld: adapt your body, but this is extreme.
i love it.
it's so wiliamsburg hipster meets thom browne but hi i am a phD candidate for economics and 19th century russian poetry.
No, not personally attractive -- but can't help but admire it as a piece of self-crafting. We're not all "beautiful", after all--so once you've accepted that, then why not go on to work freely with conventions, colors, bodyhair, etc? This feels like a riff on, oh, Lytton Strachey. (Can I be your Virginia Woolf?)
xo Gyoza
Very Dickensian. Doesn't work for me. He looks too preciously self-conscious with his too-short pants and too-tight jacket. They look as though they belong to his granny. And I detest big thick bushy beards. Give me Mr Crangi in his Barbour with his sexy beard anyday. Now HE looks splendid!!!
Mmmm... well. I like the idea that he walks dressed like this in the street, I mean, it's original and nicely old-fashioned. But, it realy seems like he dressed up as a "50's university professor". Tryed too hard. I like the shoes though. The rolled pants.. no. The beard and the whole look makes him look much older than he must realy be.
Love his individual style. He looks like a proper eccentric. As long as he is as interesting to talk to as he is to look at this guy is ace! Love the beard!
He's between a modern Charles Darwin and an orthodoxian russian priest...so unusal looking nowadays.
I love the plaid set on the diagonal.
Il fait classe, très professeur. Il a l'air d'en savoir des choses.
Bref un look comme je les aimes.
He looks so Hermès, because of the color, love his style, nive one ^.^
So charming!! He looks like he'd buy you a drink before telling you about Jesus.
The gentleman has a very long neck. He needs the beard. And to roll down his trousers. And a cigar. And to unbutton the front of his shirt like an Italian. And a pocket square. And a pinkie ring. And to be in Milano. And yeah... he'd be rocking the Kasbah!
This dude is all about the details. Love it.
i want to live there, maybe it's something about the colors in his outfit, a little pop of color with such beautiful architecture in the background
plaid on the cross ... quirky.
I love this chaps charming and unique style. I think he looks a bit like Alber Elbaz. Nice boots too!
I'm sorry, but that's just complete overkill. It's not a stylization, it's fancy dress.
those shoes are incredible! i wanna hang out with this guy and watch 'russian arc'.
sorry, just cannot understand the "hommeless" style
the cuffing of the pants is interesting
Somerset house is so beautiful!! And this man it's kind of interesntig! :)
he looks fantastic, i adore his kind of style!
So Ginsberg!
Poor last time and even poorer now. London has such a rich tapestry of fashion but this guy is sadly a cast off.
He certainly is a mix of time and fashion. I really enjoy his use of color and pattern. Great looking shoes. Not too sure about the cuffed pants, they seem a tad too short, but I've seen others wearing their pants this way so maybe it's me who is out of the loop? Surely he is a professor or a scientist. He's got that look. I've always found the thinkers to be sexy.
I'm a big fan of the brogue boots (poss Grenson?) but the beard is too much. But I'm sure he'd be a hit in Utah polygamist circles.
english 1950's man
That beard is the truth. Love the shoes with the trousers
I love it! Looks like a hobo! Awesome.
The beard!
He's channelling the Bloomsbury writer Lytton Strachey.
One of my favourite places in London. The Courtauld is a must. Not quite sure if this fellow adds to the place's charm, but if ever there was a manly beard, that is it.
LOVE the rusty orange with grey...yes, that's the way we spell it here in Ontario ;)
I love that shoes are being shown off by men lately - they are just as vain when it comes to their favourite footwear. I would rather see his trousers simply shorter, not deliberately rolled. (see Grey and Red, Pitti Uomo Jan. 25th) Just my preference.
Great photo and setting!
what a fantastic human being! love the layers and textures
nicely done Scott.
Absolutely brilliant!
Perfectly provincial.
This is obviously a man who doesn't care what anybody else thinks and I like that. But for me the fit ruins everything. Hate the high-water pants. Looks a little Amish ... but I'm sure he's a great professor, he has a sweet stance.
this is incredible! from his pose, the combination of colors- in his clothes and the background, the overcast, dispersed lighting; so amazing! I love it! This is truly one of your best.
Not sure I like trousers at half-mast. Looks like they just don't fit....
Good job louise or valentine... you nailed it!
Nice wingtip boots and generally composed look. Very thoughtful
Love the blazer in combination with the rolled up trousers! xo
ha! now that's what I call an "odd jacket."
I'm just not liking his beard.
one of the more awesomer looks for sho.
...boots are radical!
This'd look great if he'd just picked sizes that fit him. I don't get the "too-short, too-tight" thing, I guess.
This does not inspire me at all.Very few people can pull of the shorter pant.The look is contrived.
Mr Banks looks fantastic though.
just add a cone hat for the keebler affect. i'll pass on this look, thanks.
I have mixed feelings about the short pants, otherwise, great.
He sort of looks like he's trying too hard, and I usually like beards more trim, but for some reason, this look really appeals to me. The pose and slightly quizzical expression make me think he would be an interesting person to know.
He looks quirky and well put together. Terrific!
I love the blazer, the cut makes it look contemporary and refined. The color scheme is perfect, I really like how it all looks great with his hair/beard color. And the shoes, please don't overlook the shoes!!
I love the blazer, the cut makes it look contemporary and refined. The color scheme is perfect, I really like how it all looks great with his hair/beard color. And the shoes, please don't overlook the shoes!!
Oh, these pants are so absurd..no to mention the hairstyle&beard... Love the shoes and the cardigan, though!
The neautral palette with pops of orange or red seem to be it for a/f 2010. Peter Pilotto and Issa London did it fabulously at LFW.
I LOVE THIS PHOTO!!!! This is really really a stunning picture, Scott! Wow. I can't get over it. The background, the way he is standing beside the fence. His outfit!!!! (Which I think fits him perfectly, btw....) the way he's cuffed his pants is my favorite part. The colours in the photo. Wow wow wow. I'm saving this. So beautiful.
A bearded man is a manly man! How much more so when he is draped in peeking orange and wonderfully rolled up cuffs. There is much beauty to be found in a rolled cuff. Remember that.
What a fantastic shot!! I wonder how many years of growth went into that beard?!? Wonderfully eccentric.
check out my blog for more:
The pants are too short. His shirt collar size appears to be too large. As a result, he looks ....Pythonesque. "My brain hurts!"
u have some of the most interesting people in ur pictures
Yes and no.
Yes, I love his whole ensemble.
No, I don't like his posture.
Hey, this guy is at The Style Scout as well...
I love everything about this man
I don't like it. An immediate reaction that I've never had to one of your picks before. Style emanates from within (as your London Shine shot of a few days ago beautifully illustrates), and these are merely clothes this man has put on. Or, as a friend of mine likes to say, "The clothes are wearing him".
I also think (in armchair psychologist mode) that the bushy beard strongly suggests that this person's inner essence, whatever it is, is actually being hid under all the layers, not flowing up and out through them into the world.
And - is it just me, or does the jacket simply not fit well? I just don't think it has a nice cut.
I like the top half of this outfit with the fitted plaid jacket and a bit of orange cardigan showing. But I have just never been into the rolled trousers look. I will be so happy when that has run its course.
As a bit of a beard 'amateur', I wouldn't say his beard suits him especially, and I don't particularly like anything he's wearing. But an outfit can be so much more than the sum of it's parts, and whether it was intentional or not, I really enjoy the awkwardness of the whole look. Kinda imagine him as an classical school teacher or librarian or something!
One word: YES!
I love everything about this pic, colors, setting, composition. TIMELESS.
Sorry, but he looks like a Monty Python character. I think it's the 1970 retro haircut and beard.
I do like the olive gray and orange color combination. And I like the jacket pattern, but it's too short. Isn't a blazer supposed to cover your bum?
Love the boots! I'm ambivalent on the roll-ups as a general style, but I will say that he has long enough legs to pull it off.
This is the cutest dude I've ever seen. I want to smooch him. Nay: I WILL smooch him.
Magni is an Icelandic hairdresser and designer/owner of Kron by Kronkron http://kronbykronkron.com/. They make the most beautiful shoes. He's been photographed here before with his wife, fantastic and very colorfol couple:)
I had no idea mormons were in this season.
I want those shoes! Anyone know where to get them? Scott? haha
I bet he has a manifesto and a cabin in Scotland.
Hate the beard, love the clothes. My guess would be that he's a Jacobean scholar.
Dandyesque ;)
Love it Personal Style on a man is Sooooo sexy....and the redheaded fellow .....A plus!!!!!
arrrgh BOOTS! i think we may almost have the same pair...although with so many brands around these days most likely not. though identical from what i can see!
This is a great composition, love the picture. The angle up to the mansard windows grabs the gray London sky and thrusts light into the center; the railings, arch and balustrades define the space; the strong perspective of the stone facades draws the eye to the arch; the cobblestones, also oriented toward the arch, have all the tones of his outfit. His zig-zaggy jacket plays off the close repetition of the iron fence, the shoe laces parallel the iron railings, and the orange in the shoes and vest sing it up.
Wouldn't say Dickensian, but definitely scholarly.
Boots are Grenson Broag High tops i believe, English Made. I have the same Pair. Beauitful outfit, love the orange and plaid mix match.
This picture is truly amazing, don't know what I like best, the clothes or the photo :P
Nice outfit!
@ Josh
this guy is part of KronKron designer team/couple. His name is Magni
you can probably contact them through their onlinestore about those shoes.
Magni is a very talented person.
Here is the picture The Sartorialist took last october of Magni and his wife Hugrún:
They own the Kron shoe store in Iceland selling awesome shoes including their own shoe design: http://kronbykronkron.com/
They also own the Kron Kron store selling designer clothes: http://www.kronkron.com/
Plus they are just really nice people...
I wonder if he is aware of how absolutely wonderful he looks? This is such a great photograph. Well done.
This man is fantastic
WHat shoes..PLEASE...WHAT SHOES!!!!
YES! this is what i call living a personal lifestyle!
nice trickers. agree the beard is good for the long neck / sloped shoulders / receding hairline. good choice of specs too. he looks great
Love this man's personal style. The bias cut plaid jacket, short rolled pants, orange cardigan peeking out, and overall mix of colors all feel so casual yet studied.
Is the spitting image of how my dad looked in the 70's with the really bushy beard and the hair.
Sorry, but that beard gives me the creeps.
Nice boots - shame he got dressed in the dark!!
beautiful colors. the picture just transports one to a bygone era.
I like this picture, especially the combination of old stones against his beard. You also can tell that he is an artistic dresser and has spent time scowering the city for each piece probably on a tight budget. Well done sir


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I just hope its one of the easier carded figures to get, around the 80-100.00 dollar mark and not the 300.00 ones.
Jeff, was this to be carded?
Anybody know how we'll be able to get these in the US (other than eBay?)?
Any opportunity for a group purchase among the MN collectors? I might be in for one or two of these depending on price.
STAR WARS (TM) KUBRICK SNOWTROOPER (TM) (BLUE STARS ver.)About purchase method (By all means please read.)Order important points please be sure to read. Application acceptance period >Up to 2007 December 24th (Monday) 0:00 - 2008 January 10th (Thursday) 23:59 Commodity dispatch period >2008 May schedule While you apply from, with pulling out selection in 2,007 names"STAR WARS (TM) KUBRICK SNOWTROOPER (TM) (BLUE STARS ver.) "You can purchase.Applicationto "per 1 family (1 address 1 address) makes1 body".In addition the separate postage is necessary. As for sending item payment on delivery flight and only application with credit liquidationYou can point, when postage + dispatch expenses payment on delivery flight you are, XXYEN 1,500, in case of credit liquidationXXYEN 840 is added. Please acknowledge beforehand. STAR WARS (TM) KUBRICK SNOWTROOPER (TM) (BLUE STARS ver.) XXYEN 1,575 (including tax) Note *As for announcement of purchase right successful candidate, to 2008 January 31st action pulling out selectionAt the mail you communicate from our company. With input mistake and the like of e-mail addressWhen you cannot send the mail, because election right it becomes invalid, please acknowledge beforehand. *After the being elected, reception number by all means becomes necessary the occasion where it advances to liquidation form.As for this when applying being to be stated in the acceptance refrainment mail which reaches to election announcementThat carefully storage, we ask. Furthermore, when reception number it is lost,When you cancel, no soldier/finishing which is please acknowledge. *When to apply better wooden pail address and the like has mistaken, entry (input) and so on it leaks, with,When you cannot deliver the commodity, election right becomes invalid. Please acknowledge beforehand. *When receipt refusal of the commodity and the delivery of long-term absence and the like it is impossible,When and you do the cancellation procedure with stipulated private cancellation form,Because election right becomes cancellation, please acknowledge beforehand. *When invalidity of election there is right and cancellation and the like, cancellation amountApplication while receiving from, (from midst of one which is not elected) you make re-pulling out selection. *Because application becomes 1 limit, (input mistake and the like of especially e-mail address) after you note whether there is no error in the contents which the register it receives, please be sure to apply. *We can answer to the inquiry regarding the pulling out selection result and the like, altogether and are unable because,Please acknowledge. *Because, procedure of means of settlement is stated in the verification mail, please be sure to refrain. *As for dispatch we plan 2008 May without notice, but depending upon application number of casesThere are times when it delays. Please acknowledge beforehand. *The sending item makes only the Japanese country. We will not accept the order from the outside of Japan and will not deliver this to abroad.
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CORAL GABLES, Fla., May 16 (UPI) -- New York Knicks forward Amare Stoudemire has enrolled at the University of Miami, where he is pursuing a bachelor's degree in general studies, UM said.
Stoudemire, 29, who entered the NBA straight out of Cypress Creek High School in Orlando, has enrolled in summer classes, the South Florida Sun-Sentinel reported Wednesday.
He posted on his Twitter account: "Just enrolled at the University of Miami. Working on continuing my education."
He included a photo of himself making a "U" sign.
Stoudemire missed a playoff game against the Miami Heat after he punched a fire extinguisher enclosure following a recent loss at AmericanAirlines Arena, the Sun-Sentinel said. The Knicks were knocked out of the playoffs by the Heat.


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It is more than frustrating to have an outdated printer which works slowly and produces copies of less than perfect quality. If you think that it is time to get a new device, you have to ensure that you will make the best choice. For this, you must take into account the following important criteria when you go shopping.
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In addition to the standards units, you will also find multi-function printers also known as MFPs. These have one or more functions in addition to printing. The list of extra functions which you can get includes scanning, photo copying and faxing. It is typically less expensive to opt for a multi-function device. It can save you a lot of space and hassle too. You just have to ensure that each of the function is performed excellently.
The portable printers are smaller and lighter than their traditional counterparts. They are equipped with ink jet technology. They work with standard-size paper sheets. They can be easily carried around in a bag. They offer good quality, even though they are not on par with their most advanced stationary counterparts toko komputer online terpercaya. Still, the fact that you can take such a unit with you anywhere and use it whenever the need arises can be a major advantage.
All modern printers are designed to be connected to computers via USB cables. If the device will be set up in an office where a network is used, it should have an outlet for a standard Ethernet cable as well. You should definitely consider a model with Wi-Fi connectivity. This is an important feature for people who want to use mobile printing on a regular basis. If you go for this option, you should check to see whether there is an app which is especially designed to facilitate the process.
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This specification refers to the maximum number of paper sheets which the device can store. It is important to note that it will vary based on the thickness of the sheets which are used. In any case, when selecting a particular unit, you should confirm that the number of sheets which it can store is higher than the number of sheets which you use for printing per day. This will save you time and hassle.
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There have been many reports about a U.S. Marine Wounded Warrior who was recently screened at Phoenix (PHX). Unfortunately, there has been a lot of misreporting.
After reviewing TSA video (CCTV), interviewing and receiving written statements from all Officers involved, we found that the Marine was not asked and did not remove his prosthetic legs. The screening was done by the book and lasted a total of 8 minutes from beginning to end. By chance, the screening was conducted by two TSA Officers who were prior military. One was in the U.S. Air Force for 18 years, and the other was in the U.S. Marine Corps for 13 years.
Nevertheless, we strive to ensure that all veterans and individuals with medical concerns are treated with dignity and respect. 25 percent of TSA employees are prior military. Some are even still serving in the reserves and guard. I'm a veteran as well. We have the greatest respect for our men and women serving in the military and strive to screen them with thedignity they deserve.
Through our Wounded Warrior Screening program, we strive to make the overall experience for wounded service members as simple and trouble-free as possible. In the coming days, we will expand the Wounded Warriors Screening program to offer TSA Pre✓®, or expedited screening, to this group of veterans.
TSA Officers at Phoenix (PHX) alone have screened and assisted 164 Wounded Warriors over the past year.
We value the continued commitment of our veterans and active duty military employees to TSA's mission, and to ensuring the safety of all Americans. See some of TSA's proud servicemen and women here.
Bob Burns
TSA Blog Team
If you have a travel related issue or question that needs an immediate answer, you can contact us by clicking here.


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Yohji Yamamoto Inc. and Yohji Yamamoto Group companies (herafter the "Company") regard customers trust as a foremost priority. In accordance with the act concerning the protection of personal information ("personal information protection act") and with the Company's privacy policy, the Company enforces strict management of customers personal informations, handles them according to each customer's preferences, and makes efforts to preserve the accuracy and confidentiality of those informations.
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Allegations against Smith are dropped
copyright the Chronicle February 10, 2016
by Joseph Gresser
MONTPELIER — The 80 or so supporters of Annette Smith who filled the Cedar Creek Room at the State House here Monday arrived spoiling for a fight.
Their emotion changed from anger to jubilation when Ms. Smith's lawyer, David Sleigh, announced that the state Attorney General's office had found no merit to allegations that she has been practicing law without a license.
Ms. Smith, who heads Vermonters for a Clean Environment (VCE), has worked with a number of individuals and towns opposing big wind and solar projects, including some in Orleans County. Although she does not speak on their behalf in proceedings before the Public Service Board (PSB), she does provide advice on the process, and she helps with documents and… To read the rest of this article, and all the Chronicle's stories, subscribe:
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Sunspace Modular Enclosures began modestly in 1991. In those early start-up days, the owners went to the client's project site, measured their deck and drew the design of the Sunroom by hand. They would cut and assemble all the parts and install the Sunrooms themselves.
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STEUBENVILLE, Ohio (AP) -- Police say they believe a man found dead at an industrial site in far eastern Ohio was trying to steal copper electrical lines from the former steel plant.
The body was found Monday by an employee of the company that now owns the former RG Steel plant in Steubenville (STOO'-behn-vihl).
Acting police Chief Joel Walker tells the Steubenville Herald-Star (http://bit.ly/18XFdjL ) authorities believe the man had been on an electrical tower over the weekend and died either from an electrical shock or a fall.
The 51-year-old local resident previously had been charged with trying to steal copper from the same property.
Walker says police have seen signs that others might be trying to do that, and he hopes the tragedy serves as a warning.
Information from: Herald-Star, http://www.hsconnect.com


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Having a college where doctors can train, clinics for the sick to find healing, and a pharmacy to provide the medicines is Chagpori's basic requirement. Chagpori provides Tibetan medical health care regardless of colour, creed, caste, religion
In November 1992 with the blessings of HH the Dalai Lama, the new Chagpori Medical College - now known as Chagpori Tibetan Medical Institute (CTMI) - was inaugurated at Darjeeling, India, in commemoration of Chagpori, Lhasa, Tibet.
Dr. Trogawa Rinpoche had spent many years waiting for this day.
He had originally hoped to establish the new Chagpori in Nepal, but despite the expenditure of considerable time and money it was impossible to achieve. In 1989 his brother Tashi resigned from his job in order to help. Rinpoche took students into the family house in Darjeeling in 1990, and in 1992 the school came a step closer when it moved for three years into Hawk's Nest, a property of one of the Board members, also in Darjeeling. Even after the CTMI was officially established and formally recognised, Rinpoche continued looking in Darjeeling, Kalimpong, Siliguri and Sikkim and finally, after consultation with other high lamas, the present location at Takdah was chosen.
Chagpori Tibetan Medical College is at this moment located at Takdah Cantonment, about twenty-seven kilometres from Darjeeling.
The College has been training students since 1992. The students have to complete five years of studies after which they have one year of internship. During the first five years they study the theory and basics of Tibetan medicine and also Tibetan grammar and English.
During the internship period the students are given the opportunity to learn the different aspects of clinical practice and medicine-making. Throughout the entire period emphasis is also on the study and practice of the Medicine Buddha rituals and dharma teachings related to healing. These are the important aspects which characterise the Chagpori system of medicine.
In the present fourth intake (or batch as it is usually known in India) there are nine students, mainly nuns. As there are only a few lady doctors in our community, we sincerely hope that they will be of benefit to all. They completed their medical studies in December 2009. From March 2008 we admitted fifteen new students for the fifth intake. We are still looking for sponsors for the students who are not able to cover the expenses of their studies.
In 2011 Admission for the sixth intake of students is scheduled in June .
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ExPatriatePen wrote:npv708 wrote:Are you trying to tell me there weren't security concerns in Beirut in 1983 that weren't fully addressed? Really? Beirut 1983 is far more dangerous than Libya in September 2012.
Bengahzi didn't even have the security that the Beruit barracks had. Almost 20 years later. And no, Beruit didn't ask for additional security and yes, they at lest had US marines guarding the barracks, not local militia forces.
My father-in-law was deployed to Beirut in '58, and my uncle helped clean up the mess there in '82.
You are both quite right..... what happened in Benghazi this past year bears no resemblance whatsoever to Beirut. And I invite you both to stop making comparisons between the two.
DelPen wrote:For every $1 raised in taxes they need to cut $2 in spending at minimum.
And yet, at one of the debates during the GOP primary this past year when a field of 8 or 9 presidential contenders were given the following scenario: "Raise your hands if you would accept a deal that included $10 in revenue cuts for every $1 in increased tax revenue," not a single one of them raised there hands. All hail, his highness Sir Grover. Or something.
The country is at an impasse in terms of the type of government people want, versus the amount of money they are willing to pay (via taxes) to fund it. Income taxation is at a level that's lower than nearly all of us on this board have known in our lifetimes. Shoot, Mitt Romney took a punch on the nose for saying something that's essentially true: nearly half of this country pays no income tax whatsoever. (Okay, he phrased in a way that was entirely unpalatable, but that's a side issue.) Yet we still manage to spend 40% more than we collect in tax revenue. That's a bit of a wonky construct.
Where to cut? Reps refuse to even countenance cuts in defense spending, and Dems clam up and shut down if you suggest entitlement reform. Guess what? Excluding Defense and entitlements means you are left addressing about 12% of the non-discretionary budget. All the cuts are going to come from there? Really?!?
ExPatriatePen wrote:It's completely dysfunctional right now. Hell, I was able to 'retire' for nearly two years and collect unemployment benefits. (thanks uncle Sam). Not one time did anyone check my situation. They just sent me two years of unemployment checks. That's two years of me collecting and them not getting taxes.
Then you no longer get to complain about the situation.
If you are so happy to sit back and claim your benefit and then get all huffy about the government actually paying you (without even checking!) then you, sir, are part of the problem.
I come here and post that I am willing to pay more taxes (temporarily) to help dig out from the deficit and debt albatross around this country's neck. You come here and boast that you've quite happily mooched government benefits that you didn't really deserve for two years. And yet I'm the one that gets chastised.
I no longer want my tax dollars subsidizing ExPat's faux 'retirement'. Is there a form I can check on my return to prevent that happening?


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(CNN) -- Malky Mackay was "relieved of his duties" as manager of Cardiff City Friday just 11 days after being told by the English Premier League club's Malaysian owner Vincent Tan he must resign or be sacked.
A statement on the club's official website confirmed the fate of the 41-year-old Scotsman, adding that a new first team manager would be appointed in due course.
The departure of Mackay was widely expected after his very public falling out with billionaire businessman Tan, who has had a controlling share in the Welsh club since 2010.
Tan sent Mackay an email on December 16, with the resign or be sacked ultimatum.
Read: Promoted Cardiff shock Man City
He criticized Mackay's signings and the team's style of play and said he would be given no further funds in the next transfer window.
Tan's intervention infuriated Cardiff fans, who were out in force in matches against Liverpool and Southampton during the Christmas period to protest over their manager's treatment.
After the 4-1 defeat to Liverpool, Mackay was given a brief reprieve when club chairman Mehmet Dalman said he would remain the manager for the "forseeable future."
But the 3-0 home defeat to Southampton proved his final match in charge as he becomes the sixth EPL manager to depart this season.
Mackay was appointed by Tan in the summer of 2011, a year after the Malaysian took control and success came on the pitch with an appearance in the 2012 English League Cup final at Wembley.
Read: Cardiff fan deserts club over club colors change
Cardiff narrowly missed out in the playoffs to secure promotion, but made no mistake last season by winning the second-flight Championship.
Off the field, while the Cardiff fans welcomed Tan's investment into the club, there were protests when he changed the club's traditional blue strip -- they are nicknamed the Bluebirds -- to red.
The majority appear to have been behind Mackay during the recent saga and there were several "Tan Out" banners unfurled at the Southampton game.
The defeat left Cardiff in 16th place, one point above the relegation zone and the new manager -- former Manchester United star Ole Gunnar Solksjaer is the early favorite -- will be judged on their ability to avoid the drop.


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Physical Sciences
Research Highlights
May 2009
The Curious World of Water and Ions
Noted chemist shares insights with packed auditorium at Pacific Northwest National Laboratory
Dr. Rich Saykally
The success or failure of solar cells, fuel cells and other alternative forms of energy relies on understanding interactions between ions and water. Researchers such as Dr. Richard Saykally and his colleagues at the University of California, Berkeley are applying new techniques to learn more about these interactions. Saykally recently spoke to scientists at the Pacific Northwest National Laboratory's Frontiers in Chemical Physics & Analysis Seminar Series. The series features academic, government, and industrial leaders who discuss novel ideas and advancements in science.
"Having Richard here was both informative and entertaining," said Dr. Wayne Hess, leader of PNNL's Chemical Physics & Analysis Group and organizer of the seminar series. In his talk, Saykally discussed Hofmeister effects and the ionization of water.
Handling Hofmeister. In the early 1900s, Franz Hofmeister observed that different ions have different strengths in their interactions (e.g., unfolding) with proteins. With careful study and observation, he ranked these strengths, creating the now infamous Hofmeister series, and this same ranking is observed for many different phenomena. The series is infamous because the mechanism behind it is unknown.
Saykally and his team are working to determine the mechanism behind the series. While some theories point to polarizability and ion size, Saykally and his colleagues used femtosecond laser spectroscopy to examine water molecules around simple ions. Based on the experiments, the team believes that the Hofmeister series can be explained by short-range perturbations of the waters of hydration as the ions approach an interface.
Turning Water into Lightning? In studying the Hofmeister series, the team used jets of water that emitted only a few molecules of water. Using these jets led to additional experiments when the team inadvertently turned a jet of water into a bolt of lightning. They found that when water comes through a nozzle, the liquid contains more positive ions (H3O+) than negative ones (OH-) because the OH- attaches to the metal of the nozzle, while the positive ions come through. "You can get enough charge separation to create lightning bolts, which was unfortunate for some of our experiments!" said Saykally.
About Dr. Saykally: Dr. Saykally is a chemistry professor at the University of California, Berkeley. His research focuses on laser spectroscopy of liquids, surfaces, and clusters. Recipient of the Berkeley Distinguished Teaching Award, he has advised 57 Ph.D. and 7 M.S. students as well as 39 post-doctoral fellows. He is co-author of more than 360 scientific articles and recipient of many awards and honors.


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Item 1 of 19
William Haley letter to son in Sebago, 1864Item 63410 info
Sebago Historical Society
William Haley writes from the hospital in Camp Keyes in Augusta where he is recovering from the illness he contracted in Louisana.
In this letter to his son John, age 12, his concern about his farm and family are evident. He talks about weaning the colt and cutting the wheat and includes messages for John to give to his sisters.
He asks John to "kiss billy (his younger brother) for me."


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The Other Side, one of the last gay bars in Silver Lake and one of the city's last remaining piano bars, is closing and will be replaced with a sports bar. The new Hyperion Public will also be taking over the Flying Leap Cafe, which is next door on Hyperion Avenue and shares a common owner with The Other Side. A notice on the door of the Flying Leap by owner Paul Hargis says:
It is with warm reflection that I pass along the bittersweet news of the closing of The Other Side and Flying Leap Cafe on June 24, 2012. Both have achieved landmark status in their own right, and each has had a real impact on the exciting Silver Lake food and entertainment scene over the past fifteen years. It also marks the end of an era for one of the longest continuously open piano bars in Los Angeles, with its original roots back to the late 1960s.
The Other Side and its regulars of older gay men were featured in a 2006 documentary – "The Other Side: A Queer History" – made by Jane Cantillon. "We are all so sad it's closing down," said Cantillon, who will be updating her film to include the bar's upcoming closure.
The Other Side becomes the most recent Silver Lake gay bar to close as the neighborhood's once vibrant gay bar scene and nightlife fades away.
Click on the link below to view a film trailer of "The Other Side."
Related Link:
- Silver Lake celebrates it's gay past but what about its future? The Eastsider


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HSCT for High Risk Inherited Inborn Errors
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
|ClinicalTrials.gov Identifier: NCT00383448
Recruitment Status : Completed
First Posted : October 3, 2006
Last Update Posted : April 24, 2015
- Study Details
- Tabular View
- Results Submitted
- Disclaimer
- How to Read a Study Record
Hematopoietic stem cell transplantation has proven effective therapy for individuals with adrenoleukodystrophy (ALD), metachromatic leukodystrophy (MLD) or globoid cell leukodystrophy (GLD, or Krabbe disease). This protocol also considers other inherited metabolic diseases such as, but not limited to, GM1 gangliosidosis, Tay Sachs disease, Sanfilippo syndrome or Sandhoff disease, I-cell disease (mucolipidosis II).
For patients with advanced or rapidly progressive disease, the morbidity and mortality with transplantation is unacceptably high. Unfortunately, there are no viable alternative therapeutic options for these patients; if transplantation is not performed the patients are sent home to die. Our group at Minnesota has developed a new protocol incorporating transplantation using a reduced intensity conditioning regimen designed to decrease toxicity associated with the transplant procedure. This regimen will make use of the drug clofarabine, which has lympholytic and immune suppressive properties without the neurologic toxicity observed in the related compound, fludarabine, commonly used for transplantation. In addition, several agents providing anti-oxidant and anti-inflammatory properties will be used to assist in the stabilization of the disease processes. This revised transplant protocol will test the following: 1) the ability to achieve engraftment with the reduced intensity protocol, 2) the mortality associated with transplant by day 100, 3) patient outcomes, based on differential neurologic, neuropsychologic, imaging and biologic evaluations prior to transplantation and at designated points after transplantation (day 100, 6 months, 1, 2 and 5 years). Additional biologic studies will include pharmacokinetics of clofarabine and mycophenolate mofetil (MMF). In addition, for patients undergoing lumbar puncture studies, cerebrospinal fluid (CSF) will be requested for determinations of biologic parameters.
|Condition or disease
|Adrenoleukodystrophy Metachromatic Leukodystrophy Globoid Cell Leukodystrophy Tay Sachs Disease Sandhoffs Disease Wolman Disease I-Cell Disease Sanfilippo Syndrome GM1 Gangliosidosis
|Drug: Clofarabine Procedure: Total body Irradiation Drug: Melphalan Biological: Hematopoietic Stem Cell Transplantation Drug: Alemtuzumab Drug: mycophenylate mofetil Device: Cyclosporine A Drug: Hydroxyurea
|Phase 2
|Study Type :
|Interventional (Clinical Trial)
|Actual Enrollment :
|39 participants
|Intervention Model:
|Single Group Assignment
|None (Open Label)
|Primary Purpose:
|Official Title:
|Treatment of High Risk, Inherited Lysosomal And Peroxisomal Disorders by Reduced Intensity Hematopoietic Stem Cell Transplantation
|Study Start Date :
|September 2006
|Actual Primary Completion Date :
|September 2014
|Actual Study Completion Date :
|September 2014
Experimental: Treated Patients
Patients receiving chemotherapy (Hydroxyurea, Alemtuzumab, Clofarabine, Melphalan), Hematopoietic Stem Cell Transplantation and radiation therapy (Total body Irradiation) mycophenylate mofetil and cyclosporine A.
Drug: Clofarabine
days -7 through -3: 40 mg/m^2 intravenously over 2 hours
Other Name: Clolar
Procedure: Total body Irradiation
Administration of TBI: The dose of TBI will be 200 cGy given in a single fraction on day -1. The dose rate will be between 10-19 cGy/minute prescribed to the midplane of the patient at the level of the umbilicus.
Other Name: TLI
Drug: Melphalan
day -2: 140 mg/m^2 intravenously over 30 minutes
Other Name: Alkeran
Biological: Hematopoietic Stem Cell Transplantation
receives infusion of stem cells on day 0
Drug: Alemtuzumab
0.3 mg/kg intravenously (IV) days -12 through -8
Other Name: Campath 1-H
Drug: mycophenylate mofetil
Day -3 through Day 30: 1 gram three times daily (total daily dose 3 grams/day) if the recipient is >50 kg, or 15 mg/kg three times daily if the recipient is ≤50 kg. The same dosage is used orally or intravenously. Consider dose modification if renal impairment (GFR<25 mL/minute corrected)
Other Name: MMF
Device: Cyclosporine A
Patients will receive CsA therapy beginning on day -3. Dosing of CsA will be 2.5 mg/kg/dose intravenously (IV); if the recipient body weight is <40 kg, dosing will be 3 times daily, and if > 40 kg twice daily. An attempt will be made to maintain a trough cyclosporine level of 250 mg/L to 350 mg/L. Once the patient can tolerate oral medications and has a normal gastrointestinal transit time, CsA will be converted to an oral form at a dose 2.5 x the current IV dose (maximum 12.5 mg/kg/day as initial oral dose).
CsA taper begins at day +100.
Other Name: CsA
Drug: Hydroxyurea
hydroxyurea (HU) beginning day -28 and continuing through alemtuzumab administration
Other Names:
- Donor Cell Engraftment [ Time Frame: Day 42 ]The process of transplanted stem cells reproducing new cells.
- Transplant Related Mortality [ Time Frame: Day 100 ]In the field of transplantation, toxicity is high and all deaths without previous relapse or progression are usually considered as related to transplantation.
- Concentrations of mycophenylate mofetil (MMF) [ Time Frame: Day 3 ]MMF levels are to be sent on day +3 to the main laboratory for determinations of MMF kinetics.
- Changes in Magnetic Resonance Imaging (MRI) [ Time Frame: Day 30, 60, 100 and 1 and 2 Years ]
- Changes in Neuropsychometric Function [ Time Frame: 6 Months, 1 Year, 2 Years, 3 Years ]
- Incidence of Acute Graft Versus Host Disease [ Time Frame: Day 100 ]Acute Graft-Versus-Host Disease is a severe short-term complication created by infusion of donor cells into a foreign host.
- Incidence of Chronic Graft Versus Host Disease [ Time Frame: 1 Year ]Chronic Graft-Versus-Host Disease is a severe long-term complication created by infusion of donor cells into a foreign host.
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
|Ages Eligible for Study:
|up to 70 Years (Child, Adult, Older Adult)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
Adrenoleukodystrophy: Patients from 0-55 years of age diagnosed with ALD as determined by very long chain fatty acid testing will be eligible for this protocol if they have evidence of cerebral or cerebellar disease based on MRI testing, AND they are determined high risk for any of the following reasons:
- Age >18 years
- MRI score >10
- Evidence of aggressive disease that in the judgment of the Inherited Metabolic and Storage Disease group is sufficiently concerning to consider transplantation with a reduced intensity regimen instead of a standard full preparative regimen.
Metachromatic Leukodystrophy: Patients from 0-55 years of age diagnosed with MLD as determined by determinations of arylsulfatase A testing will be eligible for this protocol IF they are determined high risk for any of the following reasons:
- Age >18 years
- Symptomatic disease, as based on neurologic examination, or evidence of deterioration based on subsequent neuropsychologic evaluations.
- Evidence of aggressive disease such as rapidly changing MRI determinations that in the judgment of the Inherited Metabolic and Storage Disease group is sufficiently concerning to consider transplantation with a reduced intensity regimen instead of a standard full preparative regimen.
Globoid Cell Leukodystrophy: Patients from 0-55 years of age diagnosed with GLD as determined by determinations of galactocerebrosidase testing will be eligible for this protocol IF they are determined high risk for any of the following reasons:
- Age >18 years
- Symptomatic disease, as based on neurologic examination, or evidence of deterioration based on subsequent neuropsychologic evaluations.
- Evidence of aggressive disease such as rapidly changing MRI determinations that in the judgment of the Inherited Metabolic and Storage Disease group is sufficiently concerning to consider transplantation with a reduced intensity regimen instead of a standard full preparative regimen.
Patients with GM1 gangliosidosis, Tay Sachs disease, Sanfilippo syndrome, Wolman disease or Sandhoff disease or other inherited metabolic diseases including but not limited to I-cell disease (mucolipidosis II) who are determined to be sufficiently advanced or high risk based on the following reasons:
- Symptomatic disease, as based on neurologic examination, or evidence of deterioration based on subsequent neuropsychologic evaluations.
- Evidence of an expected poor outcome based on genetic testing or a prior family history of aggressive disease.
- Other metabolic disorders, including but not limited to I-cell disease, that are deemed to be high-risk for a poor outcome with a standard transplant regimen due to anticipated toxicity based on experience gained at the University of Minnesota or other centers.
Exclusion criteria:
- Major organ dysfunction.
- Advanced Disease Exclusion: Following evaluation, if a consensus of the members of the Inherited Metabolic and Storage Disease Program is that a patient is too advanced to benefit in a measurable and meaningful way from transplant, this will be communicated to the family, and transplant will not be offered. Measures to assist in those determinations may include: neurologic/neurocognitive functions such as activities of daily living, motor function, vision, hearing, interaction with environment, toileting, swallowing, or other standardized measures
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00383448
|United States, Minnesota
|Masonic Cancer Center, University of Minnesota
|Minneapolis, Minnesota, United States, 55455
|Principal Investigator:
|Paul Orchard, MD
|Masonic Cancer Center, University of Minnesota
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
|Responsible Party:
|Masonic Cancer Center, University of Minnesota
|ClinicalTrials.gov Identifier:
|NCT00383448 History of Changes
|Other Study ID Numbers:
0606M87246 ( Other Identifier: IRB, University of Minnesota )
|First Posted:
|October 3, 2006 Key Record Dates
|Last Update Posted:
|April 24, 2015
|Last Verified:
|April 2015
Keywords provided by Masonic Cancer Center, University of Minnesota:
Stem cell transplantation
Inborn errors of metabolism
Adrenoleukodystrophy (ALD)
Metachromatic leukodystrophy (MLD)
Globoid cell leukodystrophy (GLD or Krabbe)
Tay Sachs
Sanfilippo syndrome
Mucopolysaccharidosis III (MPS-III)
GM1 gangliosidosis
Additional relevant MeSH terms:
Leukodystrophy, Metachromatic
Mucopolysaccharidosis III
Tay-Sachs Disease
Wolman Disease
Sandhoff Disease
Leukodystrophy, Globoid Cell
Gangliosidosis, GM1
Brain Diseases, Metabolic, Inborn
Brain Diseases, Metabolic
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Hereditary Central Nervous System Demyelinating Diseases
Demyelinating Diseases
Mental Retardation, X-Linked
Intellectual Disability
Neurobehavioral Manifestations
Neurologic Manifestations
Genetic Diseases, X-Linked
Genetic Diseases, Inborn
Heredodegenerative Disorders, Nervous System
Metabolism, Inborn Errors
Peroxisomal Disorders
Metabolic Diseases
Adrenal Insufficiency
Adrenal Gland Diseases


text:
Thursday, September 2, 2010
I've been thinking.
So Adam has gone back to school and is gone a lot! Then when he is home, he is studying. Although both of us knew that this was the way it was going to be, and we both knew it would be hard ... it kinda hit me over the head one night this week. I didn't have a whole lot of motivation to do much, so I thought I would look at blogs. Now just FYI, I don't follow a lot of blogs. I don't really have a whole lot of extra time between my little ones and work, so on occasion while watching a movie I will "catch up" if you will.
I got to reading all of these amazing blogs about these super women, and I started to get down, thinking ... MAN I am nothing like them. I am not very creative. My kid's PB&J sandwich isn't in the shape of a star, nor have I had even a moment to do either boy's scrapbook. I think I forgot to put deodorant on today. I would love all the funds in the world to re-decorate my room, finish a few projects (like pillows for my couch), or machine quilt the quilt that I finished piecing 2 years ago, not to mention visit every grocery store in the county to get the best deals.
I had one of those girl moments ... you know ... where you cry yourself to sleep, thinking man ... life really could be better, and I could be better. But then it occurred to me ... the readers of my blog probably think that I am a super woman. I usually only post the projects I finish, and the things that "CHANGE MY LIFE". Very seldom do I put things that I did wrong, or screwed up, or even cried about. So for just a minute, I want to explain that I am just as normal as you!
1. I had acne in high school and took acutane. And was wondering today why it is at 29 years old I am getting acne like a teenager again!
2. My office desk is ALWAYS a disaster. I always have an unfinished project and my desk gets so stacked up that it takes me days to clean it off!
3. I hit my head at least once a day because I forget that I am blind in one eye. And then I cry because I am reminded that I have a handicap!
4. I do get extremely impatient with my kids and often times find myself in the laundry room when they are whining themselves to sleep at nap time, because I can't hear them in there.
5. I really just don't feel like cooking all the time. In fact, Pizza is my escape at least once a week.
6. I have an addiction to snow cones ... Pina Colada with cream on it, and found my self getting one almost every day this summer. (hummm maybe that is why I have gained a few pounds?)
7. I HATE TO READ! I really do! Unless it is a good magazine about cooking, or scrapbooking, or an occasional Real Simple magazine, I can't stand it. I fall asleep every time I try to read for longer than 15 minutes.
8. I have a led foot. That is right folks ... I have lost track of how many times I have been to traffic school.
9. I sometimes get tired of creating ... and sometimes comes more often than you think.
10. I constantly feel my love handles and shake my head, pop my zits, think my cloths are out of style, and wish I magically won an extreme makeover contest where they fly me to NYC and visit one of those day spa's like on the movie "One Fine Day".
Those are just 10 of many. See! I am just like you. But I realized today that I am good at a lot of things AND SO ARE YOU!!! Maybe different things than I am good at! I like to try and uplift and inspire women ... not to make them feel like they are worthless if they don't feel crafty all the time. Craftiness is in my blood. I was born with it. As my sister's who all used to call me Martha Stewart as a little girl. But that is one talent that the Lord has given me, and he has given all of you great talents too. So lets INSPIRE each other ... not put guilt trips on one another. Please email me if you have some wonderful ideas too! I would love to invite guests to my blog to write about something that has CHANGED YOUR LIFE!
GREAT BIG Hugs from me!
15 comments:
- Chocolate Mousie said...
This was a breath of fresh air...lol. Yeah, we are all a mess, but many people don't want to own up to it for fear that someone won't like them. Women tend to be afraid to let people see their guard down. You dropped it like a bar of soap in the shower! Thanks for sharing and thanks for the smiles. :)
- September 2, 2010 at 8:39 PM
- Megan P said...
Everyone needs this kind of thing every once in awhile! you're a normal human being and no one is perfect! but at least we own up too it! you're doing great too! just keep on trucking through!
Megan P
PS im on accutane right now and i dont know how im going to get through it!!! i hope it is worth it! because these dry lips are driving me crazy! i can't tell you how many lip chaps i have!
- September 2, 2010 at 9:09 PM
- sarahw said...
Mandy, You Rock! That's it, that's all I have to say. :)
- September 3, 2010 at 5:10 AM
- Kirsten Krason said...
I am always struggling with acne so you are not the only one! Plus if it makes you feel any better I have always thought you have amazing skin. I am so serious. I feel the same way as you all the time. I read about 100 blogs a day and I have to always remind myself that life is not a competition. I don't need to be the best at something to be good at something. I know the feeling of not feeling good enough. And I TOTALLY know the feeling of missing your husband. As we speak Josh is gone on a 4 day trip. I get lonely and depressed sometimes. But that is normal. It's okay to be sad and then I move on.
You are an amazing person. Seriously one in a million. You are way creative and not only that you have one of the best personalities I have ever witnessed. You have amazing things ahead of you in life. Just think of all that is to come for you and your family. I love you!
- September 3, 2010 at 9:19 AM
- angie ulseth said...
I would say that other talents the Lord has given you are the ability to be honest, the ability to see things from a different perspective, the courage to face what you've gone through with losing your vision in one eye, and an extreme amount of patience. It's okay to have a good cry now and then - goodness knows I have! - but the important part is to do just what you did, turn it around and realize you're you and that's all you need to be. Your husband didn't fall in love with or marry any of those other bloggers. He picked you. You can make it through this busy phase of your life, especially because you already know it won't be easy, but it'll be worth it.
- September 3, 2010 at 10:47 AM
- The Hunters said...
While I completely understand what you are saying and it is easy to criticize yourself based upon what you see others doing on their blogs I ask you to keep in mind two things.
1. Most people don't do blog posts about what is really going on in their lives such as their husband never picking up after themselves, their kids being little monsters, their lack of sleep or the growing credit card debt. Most people only write about the "good" things in life so you aren't seeing the whole story.
2. Maybe you aren't superwoman and there are things you want to do but can't right now for one reason or the other. But you get to use your creative talents to inspire others such as myself and you are in a career that some of us dream of and are insanely jealous of you for :) So maybe you aren't superwoman but you are an inspiration to others, how many of the people on those blogs can say that?
- September 3, 2010 at 3:03 PM
I was feeling down and out tonight about my unfinished projects,messy house and everything else that's not right. Then my 8 year old in the middle of movie night says I just love this family!Then I read your post and it just but the biggest smile on my face,that I am not alone. I do follow some blogs and their life seem so perfect. I love your blog and look everyday for a new post.
- September 3, 2010 at 9:20 PM
- Binxcat1 said...
Ahhhh... I KNEW I loved your scrapping... must be that we have MUCH in common! ;) Yep, I just love the tell it like it is approach... I try to do it as much as I can too... THANKS for sharing your REAL life! ;)
- September 6, 2010 at 8:27 PM
Love your honesty!
- September 7, 2010 at 12:13 PM
- amyp said...
Hi! I enjoy reading your blog and thanks for sharing part of your life. Its hard being a mom and yet so rewarding at the same time. All of us moms go through the same issues at some point or another, we are human. Love your honesty, maybe I will that on my blog soon!
- September 8, 2010 at 7:28 PM
- Sophia said...
Awesome to ready a little bit more about you...
Love your blog, always so inspiring!!!
- September 9, 2010 at 2:49 AM
- Kelsey said...
Thanks for sharing this. I think most everyone feels so inadequate at times (or all the time for me;), so it's good to see that everyone has their weaknesses and struggles. And while it's good to vent, it's so much better to find ways to lift ourselves up. Not to compare, but to find what we're good at and go with it.
- September 17, 2010 at 9:35 AM
- Katie said...
Thanks so much for sending me a link, sorry it took so long to read it. You are awesome! Thanks so much, I laughed and felt a lot like you and I appreciate your honesty. You are wonderful. Love you
- September 21, 2010 at 10:12 AM
I don't know if you remember me from the Page 3rd ward. We moved in about 6 months before you moved out. Anyway, I was in tears after I read this post because I feel exactly that way sometimes and I think you are amazing, incredible, oh so talented, shall I go on. I needed to hear that someone like you feels that way sometimes too. Thanks for your honesty and sharing your trials with us. It is such a strength to me, and hopefully others. You rock!!!! :)
- September 22, 2010 at 4:46 PM
- Natasha said...
Thank you for being REAL!!! I have been known to get down about all of the exceptional blogging women too.
- September 25, 2010 at 8:25 PM


text:
by Mark Jagord, sports information assistant
SAVANNAH, Ga. – The No. 21 Georgia College men's tennis team (11-5, 4-3 PBC) had their three-game winning streak snapped at No. 5 Armstrong Atlantic State University (11-6, 7-1 PBC) Tuesday at Bacon Park. The Pirates were coming off their first Peach Belt Conference (PBC) loss since 2009 and rebounded with a 9-0 win over the Bobcats.
The men's team lost each doubles match by an identical 8-5 score. The Bobcats' top pair, the No. 16 doubles team of sophomore Yannick Hass (Troisdorf, Germany) and senior Alex Schubert (Frankfurt, Germany) fell to Pedro Scocuglia and Jaan Kononov in first doubles.
Sophomore Taylor Powell (Martinez, Ga.) and freshman Anton Waern (Taby, Sweden) were defeated by Ignacio Hernandez and Damian Okrutny, while freshman Kyle Kinsler (Suwanee, Ga.) and sophomore Mattia Campus (Concorezzo, Italy) were bested by Pablo Gor and Juca Cerin, in second and third doubles respectively.
The Pirates took all the singles matches in straight sets. No. 33 Hass lost to No. 10 Scocuglia 6-0, 6-4 in the first spot. Schubert dropped to No. 25 Kononov in second singles, while Waern dropped a pair of sets to Hernandez at the third spot. Both Schubert and Waern went down 7-5, 6-3.
At fourth singles, Campus was bested by No. 13 Gor 6-0, 6-2. Powell lost to Cerin 6-3, 6-4 in the fifth spot; and Kinsler dropped to Okrutny 7-6, 6-0 at sixth singles.
The men's tennis team next returns to the Centennial Center Tennis Facility for matches Thursday, Saturday and Sunday against No. 46 Young Harris College, No. 15 USC Aiken and No. 7 Lander University, respectively. Thursday's match against YHC starts at 2 p.m.
The Georgia College Department of Athletics, two-time winners of the PBC Commissioner's Cup, sponsors 11 varsity athletic programs at the NCAA Division II level. As a Division II program, Bobcat Athletics prides itself on balancing the life of the student-athlete, evidenced by the teams' multiple appearances in post-season competition as well as documented academic success and community-service involvement. Sign up at @GCBobcats on Twitter and Facebook for up-to-the-minute reports, and visit GCBobcats.PhotoReflect.com to purchase photo prints from home athletic contests.


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News & Events
For the Media
As Obama Announces Higher Ed Proposals, Clarkson University Again Takes Stake in Student Businesses in Lieu of Tuition
As President Obama this week announced proposals to make higher education more affordable, including a focus on cutting-edge college practices for providing high value at low costs, Clarkson University is at the forefront for taking innovative approaches to helping students finance their education -- particularly those students who are already in business with a product or service, or getting ready to commercialize new technology.
Today, Clarkson announced its annual competition in which up to five young entrepreneurs or innovators will have an opportunity to attend Clarkson through a combination of merit-based financial aid (after accounting for other aid for which the student may be eligible) and the acquisition by the University of an ownership interest in their business ventures in lieu of tuition payments.
Applications for Clarkson's 2014 Young Innovators and Entrepreneurs Program will be accepted beginning today at http://www.clarkson.edu/equity .
"Clarkson continues to be an innovative leader in entrepreneurship education," said incoming School of Business Dean Dayle M. Smith. "This will be the fourth year of this pioneering program in which students can earn their degree and run their company at the same time."
This week, Evan Jennings, a home-schooled high school student from Lowville N.Y., who won a 2013 Clarkson Young Entrepreneurs Award, and Honeoye Falls-Lima High School student Briar Bonadonna of Honeoye Falls, N.Y., who won a Clarkson Young Innovators Award, arrive on campus to begin their college careers.
Jennings won his award for his business the E3cubestore Rubik's Cube and Puzzle Shop, an e-commerce site that sells puzzle cubes designed for speed solving and competition.
Bonadonna was named the winner of her award for her business idea the PodBottle. She has a provisional patent on the innovation, which is a bottle that can store your keys, phone, etc.
Both students will receive specialized guidance and support from faculty and alumni mentors. They will also operate their businesses in Clarkson business incubator office space, while pursuing their undergraduate degrees.
For consideration, prospective or current Clarkson students who either are operating a business or have a commercializable innovation must apply by Jan. 15, 2014. Anyone not already enrolled at Clarkson must also apply for admission to the University. Up to 10 finalists will be selected to present their business or patentable idea to a panel of expert innovators and entrepreneurs at Clarkson.
Of those 10, up to five students will be chosen as Young Entrepreneurs or Young Innovators. These students will remain responsible for other costs incurred in connection with attendance, including expenses such as housing, meals, books and supplies.
In addition, these students' businesses will receive the services of the Reh Center for Entrepreneurship and/or the Shipley Center for Innovation, advice from alumni mentors, and will be offered space at no charge in the Peyton Hall incubator. The remaining finalists will also receive services from the Reh and/or Shipley Centers and be offered space in the incubator.
Applicants must submit a completed business plan, a 90-second-or-less video that answers the question "Who am I, outside of my business?", and a brief description of their business. Entrants will be reviewed by the staff of the Reh and Shipley Centers and/or faculty with expertise related to the proposals as necessary.
Potential applicants should be prepared to discuss a vision for their business or innovation and its feasibility.
The first recipient of the Young Entrepreneur Award, senior Matthew Turcotte, is both a successful student and a successful entrepreneur with a New York state-based Web and e-commerce company, which recently bought its first building in a nearby city. Turcotte was recognized in the spring with the U.S. Small Business Administration Young Entrepreneur of the Year Award. Read more about his success at http://www.clarkson.edu/entrepreneur/profile/turcotte.html .
Sponsored by Clarkson's Reh Center for Entrepreneurship and Shipley Center for Innovation, the competition is aligned with the educational mission of Clarkson, which has a long-standing tradition of creating entrepreneurially minded business leaders who understand how to develop a successful business, harness innovative technologies and build opportunities for commercialization in the marketplace.
The innovative program was established in 2010 and featured in Money magazine as a strategy for paying for college.
Students interested in learning more about the Young Innovators and Entrepreneurs Program or applying can go to http://www.clarkson.edu/equity .
Clarkson University launches leaders into the global economy. One in five alumni already leads as a CEO, VP or equivalent senior executive of a company. Located just outside the Adirondack Park in Potsdam, N.Y., Clarkson is a nationally recognized research university for undergraduates with select graduate programs in signature areas of academic excellence directed toward the world's pressing issues. Through 50 rigorous programs of study in engineering, business, arts, sciences and health sciences, the entire learning-living community spans boundaries across disciplines, nations and cultures to build powers of observation, challenge the status quo, and connect discovery and engineering innovation with enterprise.