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Last updated: September 01, 2006
NIH and Johns Hopkins Establish a New Center to Study - Genetic and Environmental Origins of Common Disorders
NIH and Johns Hopkins Establish a New Center to Study
Genetic and Environmental Origins of Common Disorders
January 1997
BETHESDA, Md. - In a creative government-university partnership, components of the National Institutes of Health (NIH) and the Johns Hopkins University (JHU) School of Medicine have established a new research center to analyze common disorders caused by the actions of multiple genes and interactions with the environment. The new Center for Inherited Disease Research (CIDR, pronounced SY-der) will give scientists a powerful new approach to understanding common but poorly understood modern-day disorders such as cancer, heart disease, diabetes, arthritis, and neurologic and psychiatric disorders.
Operating under a $21.8 million NIH contract over the next five years, CIDR is housed in a 14,000 square-foot facility at the Johns Hopkins Bayview Medical Center in Baltimore. Expected to be fully operational in the spring of 1997, the Center will employ a staff of about 25. CIDR represents a partnership among eight components of the National Institutes of Health, the federal government's largest biomedical research institution, and Hopkins, which is home to a world-renowned medical genetics program. The eight NIH participants are: the National Center for Human Genome Research (NHGRI), which serves as the lead component, the National Cancer Institute (NCI), the National Institute of Child Health and Human Development (NICHHD), the National Institute on Deafness and Communication Disorders (NIDCD), the National Institute on Drug Abuse (NIDA), the National Institute on Environmental Health Sciences (NIEHS), the National Institute of Mental Health (NIMH), and the National Institute of Neurological Disorders and Stroke (NINDS).
The interest of so many of the NIH institutes in pursuing the genetic basis of today's most common and confounding diseases signals a significant transition in our approach to understanding disease and opens the door to exciting new strategies for treatments and prevention, says Harold Varmus, M.D., Director of NIH. "Hopkins' commitment to molecular medicine and gene research is reflected in and strengthened by this Center," said William R. Brody, M.D., Ph.D., president of Johns Hopkins University (JHU).
So far, scientists have been quick to apply new gene-finding tools developed by the Human Genome Project (HGP) to uncover disease genes. These tools now make it possible for an investigator looking for a single gene to isolate it in a matter of months instead of years or even decades. And indeed, the number of single disease genes identified using these tools has increased dramatically over the past few years. Understanding the inheritance of single-gene disorders -- the so-called Mendelian disorders -- is relatively straightforward because their hereditary patterns were well established a century ago and are still reliable today.
But most diseases of modern life -- cancer, heart disease, diabetes, arthritis and a host of neuro-psychiatric disorders -- seem to result from the activities of several genes and the interplay between a human body and its environment. The direct causes of these disorders have been hard to elucidate because they appear to be intertwined in complicated ways that have so far resisted the tools of modern science. Several genes seem to contribute to such disorders, but the effect of each gene is rather weak, making it much more difficult to understand why some members of a family develop chronic disorders while others do not.
New technologies now give us the power to go after the genetic origins of ordinary diseases that are caused by multiple genes, says Robert Nussbaum, M.D., who came to NHGRI three years ago with the aim of developing a center for studying the genetics of complex disorders. As the CIDR mastermind, he will oversee the contract from the NIH side. David Valle, M.D., Hopkins professor of pediatrics, serves as acting director of CIDR while a search is underway to fill the post.
CIDR will specialize in a technique known as genotyping -- sorting through the entire genetic complement, or genome, of disease-prone family members to search for not one, but many gene regions associated with that disease. A person's genotype refers to his or her own arrangement of the DNA letters, A, T, C or G, in a particular region of their genome and may be different from one person to the next. Differences in genotype may point scientists toward DNA regions that are involved in a disease. Whole-genome analysis allows researchers to find lots of possible disease-related changes in a person's DNA.
Though focusing on genotyping, CIDR research will take place across five main components: 1) Statistical Genetics, which applies the power of statistics to the hereditary patterns of genes to determine modes of inheritance from parents to their children; 2) Genetic Epidemiology, which applies genetic analysis gathered from disease-prone families to the general population to determine if the genetic patterns of the research families hold in large, diverse populations; 3) Medical Informatics and Database Management, which uses computer programs to store, manipulate and analyze the research data; 4) Genotyping using state-of-the-art technology to rapidly scan whole genomes for multiple gene regions associated with a particular disorder; and 5) Technology Development, which continues to refine existing and generate new ways to perform high-capacity genotyping efficiently and cost effectively.
Scientists estimate that determining the genotypes at 300 to 400 locations in DNA will give them dense enough sampling to identify places likely to contain disease genes. In studies of large groups, hundreds of thousands of genotypes must be performed to find all the regions that contain genes related to a particular disease.
Under full capacity, CIDR researchers expect to analyze the genetics of six to nine complex disorders per year. CIDR will charge investigators funded by a participating NIH institute a reduced rate of $1.00 per genotype; investigators funded by non-participating sources will pay $3.50 per genotype. To use CIDR, scientists in academic labs, NIH, and industry will submit research proposals to a panel of scientists. The scientists will make recommendations to a CIDR governing board made up of directors of the NIH institutes that fund the center.
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Cisco at Hadoop Summit
Last week we participated in the annual Hadoop Summit held in San Jose, CA. When we first met with Hortonworks about the Summit many months back they mentioned this year's Hadoop Summit would be promoting Reference Architectures from many companies in the Hadoop Ecosystem. This was great to hear as we had previously presented results from a large round of testing on Network and Compute Considerations for Hadoop at Hadoop World 2011 last November and we were looking to do a second round of testing to take our original findings and test/develop a set of best practices around them including failure and connectivity options. Further the set of validation demystifies the one key Enterprise ask "Can we use the same architecture/component for Hadoop deployments?". Since a lot of the value of Hadoop is seen once it is integrated into current enterprise data models the goal of the testing was to not only define a reference architecture, but to define a set of best practices so Hadoop can be integrated into current enterprise architectures.
Below are the results of this new testing effort presented at Hadoop Summit, 2012. Thanks to Hortonworks for their collaboration throughout the testing.
Hadoop Summit 2012 – Validated Network Architecture and Reference Deployment in Enterprise
We started this phase of testing in the lab with Hadoop on 96 Nodes (~768TB of raw disk) in a 3 rack configuration. The next step was to develop a set of tests around the following design considerations:
- Architecture
- Availability
- Capacity, Scale and Oversubscription
- Flexibility
- Management and Visibility
Some of the key findings include:
- Hadoop can fit in a variety of different architectures, but an architecture designed specifically for the Data Center is recommended. While Hadoop can work on a wide range of topologies, job completion times may be negatively impacted if our conclusions regarding design considerations are not taken into account.
- While Hadoop Distributed File System (HDFS) was designed to handle availability concerns through replication, losing connectivity to servers or racks can have a significant impact to performance, especially in small-to-medium sized clusters common in the enterprise. For example: Losing a rack in a 3000+ node cluster is far different than loosing a rack in ~100 node cluster, which is around the average size for an enterprise. This makes availability of the network an important consideration. The loss of a single-homed node due to a port/NIC/cable failure adversely impacted job completion times in our test cluster, thus dual-homing is recommended.
- A non-oversubscribed network, while ideal in theory, typically does not provide performance gain to offset the additional cost, however degree of oversubscription does matter. A more important consideration is buffer. Even the best non-oversubscribed design is still going to cause incast blocking driving buffer demands on the switch during large many-to-one traffic patters in Hadoop.
- A move to 10GE is going to be needed in Hadoop. While it is largely a cost/performance trade-off today keeping many Hadoop deployments at 1GE (or dual 1GE) Hadoop is reaching the limit of 1GE bandwidth. Testing also shows 10GE widening of the available incoming bandwidth to each node dramatically reduces the switch buffer utilization.
- Management and Visibility remain critical in the enterprise. Hadoop job completion needs to be monitored and over the time network characteristics needed to evaluated with tool available for buffer/link/system monitoring.
For more information on Cisco's Hadoop and Big Data solutions please visit www.cisco.com/go/bigdata
In an effort to keep conversations fresh, Cisco Blogs closes comments after 60 days. Please visit the Cisco Blogs hub page for the latest content.

subset: commoncrawl


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The Oklahoma Partnership Initiative (OPI),
is to increase the well‐being of, and to improve the permanency outcomes for children affected by substance abuse. The goal of OPI is to intervene effectively and early to prevent and reduce the risks for children associated with parental substance abuse.
The four (4) objectives of OPI will allow for early identification of risk, and timely referral for services, which will help improve long term permanency outcomes for children.
Universal Alcohol and Drug Screening for All Child Welfare Clients
*UNCOPE Screening Tool
Expand accessibility of services to newborns with prenatal exposure through enhanced identification & intervention
*ABC Community Education
Dr. Robin Gurwitch
Early intervention and prevention services for children of substance abusing parents through evidence based programs
*Strengthening Families Program
*New Directions
Improvements in cross‐system information sharing mechanisms to ensure consistent data collection across both systems
*Data Work GroupScreening will allow child welfare workers to identify potential substance abuse issues early and refer parents for assessment and treatment options.
OKDHS Child Welfare utilize UNCOPE substance use screening tool;
Child Welfare fax these forms, and OKDHS Child welfare referral for substance abuse assessment and treatment services to Immediate Access;
Immediate Access will complete assessment, and refer client to substance abuse treatment provider. The substance abuse provider furnishes the CW worker with a copy of the assessment
UNCOPE Screening Tool currently embedded within
OKDHS Family Functioning Assessment
Universal Alcohol and Drug Screening for All Child Welfare ClientsThe primary activity under this objective will be the training of health care professionals on substance‐exposed newborns and related issues. Outcomes under this objective would be indicated by:
* Increased reporting rate for infants with prenatal drug
* Increased assessments of the needs of parents and
* Increased referrals of parents and newborns for services;
* Decreased time from birth of child to receipt of services;
Prenatal drug exposure and parental substance abuse trainings to health professionals by Dr. Robin Gurwitch and OUHSC Staff;
450 health professionals trained to date;
Expand accessibility of services to newborns with prenatal exposure through enhanced identification & interventionNew Directions(ND), targets families in foster care, and designed to reduce the risks to children ages 3‐12, who have entered the foster care system, due in part, to parental substance abuse;
Strengthening Families Program(SFP)‐is a 14 session, evidenced based parenting skills, children's life skills, and family life skills training program specifically designed for high‐risk families. SFP has been demonstrated to impact family functioning in immediate and intermediated ways that are directly applicable to AOD abusing families in the child welfare system. (Expanding to Tulsa County 09/2010)
ADULTS:80 served
CHILDREN:92 served
FAMILIES:55 served
Early intervention and prevention services for children of substance abusing parents through evidence based programsUnder this objective, an Interagency Data Sharing Study Group will be formed composed of staff from both ODMHSAS and OKDHS, including representative from the OKDHS Technology and Governance Unit, Permanency Planning Programs and the Data Services Division; and the ODMHSAS Information and Decision Support services Division and Prevention Services.
Form Interagency Data Sharing Study Group; goal of group is to develop and implement a data sharing agreement between the two agencies that easily permit timely and routine interagency data sharing for evaluation and research purposes, while abiding by all state and federal regulations regarding client confidentiality;
Data collection & processing; rely heavily on the existing data systems within OKDHS and ODMHSAS;
Improvements in cross‐system information sharing mechanisms to ensure consistent data collection across both systems
Click tabs to swap between content that is broken into logical sections.


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VIDEO: Free Agency: Lowry Remains a Raptor
HANG TIME NEW JERSEY — The Toronto Raptors have taken care of the important business, agreeing to terms with Kyle Lowry on a new four-year, $48 million contract. After winning their division for the second time in franchise history and returning to the postseason after a five-year absence, they're bringing back their best player. Lowry is a bulldog on both ends of the floor, and if he wasn't the best point guard in the Eastern Conference last season, he was right there with John Wall.
The Raptors had one the conference's best benches as well. Greivis Vasquez and Patrick Patterson arrived in the Rudy Gay trade in December and made big impacts. Patterson spaced the floor at the power forward position, while Vasquez's passing was infectious. Toronto recorded assists on just 49 percent of its baskets before the trade and 60 percent after it.
The numbers spell out how important Patterson and Vasquez are. They had the two best on-court NetRtg marks on the team, with the Raptors outscoring their opponents by 9.9 points per 100 possessions with Patterson on the floor and by 8.5 with Vasquez on the floor. In the playoffs, Toronto outscored Brooklyn by 53 points with Vasquez on the floor and was outscored by 64 with him on the bench. Patterson was a plus-30. As it was in the regular season, they were at their best with those two guys on the floor.
If the Raptors want to build on last season's success, they need to keep the bench together. If Lou Williams (acquired in a trade for John Salmons) is healthy, it could be even better than it was last season.
On Friday, Toronto reportedly agreed to terms with Patterson, a restricted free agent, on a three-year, $18 million contract. That's Step 2.
Vasquez is another restricted free agent, meaning the Raptors can match any offer sheet he receives from another team. But with the new contracts for Lowry and Patterson, the addition of Williams, and the possibility of adding rookies Bruno Caboclo and Lucas Nogueira, Toronto is approaching the luxury tax line. And they want to make one more move.
After Joe Johnson beat them up in that playoff series, the Raps acknowledged that they need more size on the wing. Even if Caboclo is less than "two years away from being two years away," that size would have to come in free agency, perhaps from an Al-Farouq Aminu, Alan Anderson, Jordan Hamilton or Richard Jefferson. The Raptors have the mid-level exception (or a portion of it) to spend on an outside free agent.
Adding one of those guys, keeping Vasquez, and staying under the tax line will be a challenge. If Darren Collison can get the full mid-level exception (from Vasquez's former team) in Sacramento, Vasquez should surely be worth that much. Complicating matters is that Toronto is already paying small forwards Landry Fields and Steve Novak almost $10 million to ride the pine.
Back in January, SportsNet's Michael Grange reported that the Raptors would be willing to go over the line "at the right time." But if they bring everybody back, they're still a team that lost in the first round. Even if they add a piece, they still have a ceiling, especially if LeBron James remains in Miami. And if Jonas Valanciunas gets a lucrative contract extension next summer, it will overlap with the last two seasons of Lowry's deal (and the last of DeMar DeRozan's), which may be the time to think about paying the tax.
So Raptors GM Masai Ujiri has his work cut out for him over the next couple of weeks. He got the most important deal done. But his team's depth is just as critical to its success as its best player.


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YORK, Pa. – York College freshman Jasmine Smith has been named the Capital Athletic Conference Field Athlete of the Week in women's track & field. This marks Smith's first league honor and the third CAC weekly award for the Spartans during the 2011-2012 campaign (Laura Rowlands, Dec. 14 and Jan. 24).
Smith captured her first two collegiate triumphs on Friday evening, competing at the Crusader Indoor Invitational at Susquehanna University. The rookie garners this week's award courtesy of a first-place leap in the long jump with a leap of 5.17 meters (16-11 1/2). In addition to her victory in that event, that mark also proves a new Spartan record.
Smith also took top honors at the Crusader Indoor in the 60-meter dash, registering a time of 8.26 in the preliminaries (8.27 in the finals), and added a fourth-place finish in the 200-meter dash (28.15).
The Spartans return to action on Sunday, February 12, as they travel back to Susquehanna for an indoor meet beginning at 10:00 am.


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Table of Contents
Alternative Modalities
> Nasal irrigation
Nasal irrigation
Related terms
Related Terms
Antral lavage, antral washout, bulb syringe, endonasal mucosa care, hyperthermia, hypertonic Dead Sea salt, hypertonic saline, inhaler humidified warm air, intranasal douche, Jala Neti, jet lavage, nasal douche, nasal hyperthermia, nasal lavage, nasal saline solution lavage, nasal sprayer, nasal washing, nebulization, neti (irrigation) pot, power irrigation, respiratory hydrotherapy, Rhinomer®, saline lavage, saline nasal irrigation, Smiegelof's irrigation, steam inhalation.
Not included in this review
: Proetz displacement (saline irrigation combined with suctioning).
Yoga enthusiasts have used nasal irrigation for thousands of years to clear the sinuses and the mind. Today, nasal irrigation is becoming more widely accepted as a home remedy for allergies, colds, and sinus infections. Nasal irrigation can be performed up to twice daily at home or in a doctor's office, as long as it does not irritate the mucous membranes.
Saline lavage is a type of nasal irrigation that uses a warm liquid solution. Humidified warm air lavage (hyperthermia) uses heated mist, steam, or humidified air. Large-particle nebulized aerosol therapy uses a saline solution nasal spray. Occasionally, antibiotics are added to the solution.
There is variability in nasal irrigation techniques. Differences include the method of saline delivery, the strength of the saline solution, and the use of other additives. Delivery methods include the traditional neti (irrigation) pot, nasal sprayer, bulb syringe, cupped hand, and commercially available devices. The strength of the saline solution depends on the amount of salt added to the water. Additives have included antibiotics, substances that narrow the blood vessels (called vasoconstrictors), and buffers, which reduce acidity. Some practitioners recommend buffered hypersaline solution, although this may irritate the nasal tissues. Gravity-fed normal saline is often used in Jali Neti, one form of nasal irrigation.
There is growing evidence to support nasal irrigation because it is more natural, soothing, generally safe, and less expensive than many over-the-counter medications. It also does not cause side effects often associated with these medications, such as drowsiness and nausea.
The International Consensus Report on the Diagnosis and Treatment of Rhinitis recommends nasal irrigation for the treatment of swollen nasal airways (called rhinitis). There is good evidence for the use of nasal irrigation in allergic rhinitis and sinusitis. There is also promising early evidence that nasal irrigation may help treat the common cold, respiratory symptoms from occupational exposure, and wounds after sinus or nasal surgeries. Nasal saline irrigation is still the main treatment for acute rhinitis in infants because excessive use of nasal drops that narrow blood vessels is unsafe in early childhood.
It is unclear how saline nasal irrigation may work. It has been suggested that nasal irrigation may clear mucus, improve the function of the tiny hairs that move mucus through the nasal passages, reduce the number of particles that stick to the inside of the nasal passages, decrease swelling, and/or decrease levels of chemicals that cause swelling. It has also been suggested that heat from nasal irrigation may directly interfere with allergens. Vapor may stabilize the mucosal surface and reduce symptoms of congestion and a runny nose.
In traditional systems of healing, nasal irrigation is believed to help prevent against disease and improve symptoms of a variety of nasal and sinus conditions.
Evidence Table
These uses have been tested in humans or animals. Safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider.
Several studies suggest that nasal irrigation with normal or hypertonic saline may effectively treat allergic rhinitis in adults and children. Better studies are needed before a strong recommendation can be made.
Early research suggests that nasal irrigation may help treat chronic sinusitis, with improvements in sinus-related quality of life, decreases in symptoms, and decreases in medication use. Further study is needed before a strong recommendation can be made.
Early research suggests that hypertonic saline aerosol may enhance the clearance of lung secretions. More studies are needed.
Early human studies found that nasal steam inhalation may not improve common cold symptoms. Well-conducted research is needed to make a more compelling case.
There is some evidence that saline nasal irrigation or inhaled steam may improve mucus clearance in people with cystic fibrosis. Some studies have added antibiotics or drugs that affect cellular sodium channels. Further study is needed.
Studies have examined whether the amount of bacteria in the nasal passages before and after nasal surgery can be reduced by nasal washing (with or without added antibiotics or corticosteroids). Although some evidence suggests that bacteria are reduced, it is unclear if this therapy reduces the risk of infections after surgery.
Early evidence supports the use of nasal irrigation for respiratory symptoms or diseases caused by occupational exposure to dust or air pollutants. In addition, several studies suggest that nasal irrigation may be used to examine the inhalation effects of acute occupational exposure, especially to pollutants. More research is needed in this area.
* Key to grades
: Strong scientific evidence for this use
: Good scientific evidence for this use
: Unclear scientific evidence for this use
: Fair scientific evidence for this use (it may not work)
: Strong scientific evidence against this use (it likley does not work)
Tradition / Theory
The below uses are based on tradition, scientific theories, or limited research. They often have not been thoroughly tested in humans, and safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider. There may be other proposed uses that are not listed below.
Asthma, dizziness, multidrug resistance (antibiotics), nasal septal deviation, swollen mucous membranes.
Many complementary techniques are practiced by healthcare professionals with formal training, in accordance with the standards of national organizations. However, this is not universally the case, and adverse effects are possible. Due to limited research, in some cases only limited safety information is available.
Nasal irrigation is likely safe for the general population when used daily with proper technique. There are some reports of nasal irritation, nasal discomfort, itchiness, earache, cough, sneezing, nosebleeds, increased allergy symptoms, dizziness, and pooling of saline in the paranasal sinuses.
Some preparations include drugs that may cause side effects. Studies using saline plus ephedrine added have noted brief episodes of irregular heartbeat, lightheadedness, and nasal burning in a few people. Cystic fibrosis patients have experienced increased cough (that sometimes included blood), throat irritation, and chest tightness.
Nasal irrigation should be used cautiously in people with frequent nosebleeds.
After nasal surgery, nasal irrigation should be discussed with the surgeon.
People with impaired gag reflexes, such as patients with chronic illnesses or recovering from surgery, may be at risk of fluid entering the windpipe or lungs (aspiration). A healthcare provider should be consulted before starting therapy.
Irritation or burning of the nasal passage may occur if the irrigation solution is too hot.
Bacterial infections from dirty equipment are possible.
In children, nasal irrigation is sometimes performed by healthcare providers. Limited research suggests that nasal irrigation is safe in children older than seven years. However, the safety in children is unclear when nasal irrigation is performed outside of a doctor's office.
To prevent bacterial infections, disinfection treatment is effective if associated with carefully selected materials, good circuit design, and good maintenance practices.
Nasal irrigation may affect the action of other drugs, herbs, and supplements, such as antibiotics, antihistamines, anti-inflammatories, antivirals, cough suppressants, and nasal sprays.
This information is based on a systematic review of scientific literature edited and peer-reviewed by contributors to the Natural Standard Research Collaboration (
Berger ME, Jones OW, Ricks RC, et al. Decontaminating the nasal passages. Health Phys 2003;84(5 Suppl):S80-S82.
Cordray S, Harjo JB, Miner L. Comparison of intranasal hypertonic dead sea saline spray and intranasal aqueous triamcinolone spray in seasonal allergic rhinitis. Ear Nose Throat J 2005;84(7):426-30.
Desrosiers MY, Salas-Prato M. Treatment of chronic rhinosinusitis refractory to other treatments with topical antibiotic therapy delivered by means of a large-particle nebulizer: results of a controlled trial. Otolaryngol Head Neck Surg 2001;125(3):265-269.
Friedman M, Vidyasagar R, Joseph N. A randomized, prospective, double-blind study on the efficacy of dead sea salt nasal irrigations. Laryngoscope 2006;116(6):878-82.
Garavello W, Di Berardino F, Romagnoli M, et al. Nasal rinsing with hypertonic solution: an adjunctive treatment for pediatric seasonal allergic rhinoconjunctivitis. Int Arch Allergy Immunol 2005;137(4):310-314.
Garavello W, Romagnoli M, Sordo L, et al. Hypersaline nasal irrigation in children with symptomatic seasonal allergic rhinitis: a randomized study. Pediatr Allergy Immunol 2003;14(2):140-143.
Greiff L, Anderson M, Wollmer P, et al. Hypertonic saline increases secretory and exudative responsiveness of human nasal airway in vivo. Eur Respir J 2003;Feb, 21:308-312.
Heatley DG, McConnell KE, Kille TL, et al. Nasal irrigation for the alleviation of sinonasal symptoms. Otolaryngol Head Neck Surg 2001;125(1):44-48.
Passali D, Damiani V, Passali FM, et al. Atomized nasal douche vs nasal lavage in acute viral rhinitis. Arch Otolaryngol Head Neck Surg 2005;131(9):788-790.
Rabago G, Manito N, Palomo J, et al. Improvement of chronic renal failure after introduction of mycophenolate mofetil and reduction of cyclosporine dose. J Heart Lung Transplant 2001;20(2):193.
Rabago D, Zgierska A, Mundt M, et al. Efficacy of daily hypertonic saline nasal irrigation among patients with sinusitis: a randomized controlled trial. J Fam Pract 2002;Dec, 51(12):1049-1055.
Ricchetti A, Landis BN, Maffioli A, et al. Effect of anti-fungal nasal lavage with amphotericin B on nasal polyposis. J Laryngol Otol 2002;116(4):261-263.
Shin SH, Ye MK. Effects of topical amphotericin B on expression of cytokines in nasal polyps. Acta Otolaryngol 2004;124(10):1174-1177.
Tano L, Tano K. A daily nasal spray with saline prevents symptoms of rhinitis. Acta Otolaryngol 2004;124(9):1059-1062.
Wormald PJ, Cain T, Oates L, et al. A comparative study of three methods of nasal irrigation. Laryngoscope 2004;114(12):2224-2227.
Copyright © 2011 Natural Standard (
The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.
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Our fleece jacket has the college crest embroidered on the left chest with college name above and "OXFORD" below.
This item is embroidered to order, so please allow an extra two weeks in addition to standard delivery time. We regret that we are unable to offer a full refund for special order items except in the case of faulty goods, so please refer to the size guide 'Men's / unisex chest sizes'. Exchanges are possible for another size of the same product.
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April 15, 2005
Now you can find out by participating in the world's most ambitious project tracing the genetic and migratory history of the human race.
Members of the general public from all over the world can supply their DNA to the Genographic Project, and scientists at The University of Arizona in Tucson will do the genetic analysis. The public DNA sampling is part of a larger undertaking to unravel the origins and migratory history of mankind thousands of years back in time by analyzing genetic samples from at least 200,000 people all over the world.
National Geographic and IBM are embarking on the Genographic Project, a landmark, five-year global study of human migratory history. The project will reveal how our ancestors diversified into different groups and what routes they took as they spread out over the Earth.
One major aspect of the project is doing field research and collecting DNA samples from indigenous peoples throughout the world. The field component of the project is underwritten by the Waitt Family Foundation.
UA is participating in a different aspect of the project, analyzing samples submitted by the public. Individuals can become part of the project and learn about their own ancestors by buying a participation kit and submitting their DNA sample.
"As more people provide their genetic information to the project, researchers will be able to fill in the local details of how people migrated across the Earth," said Michael Cusanovich, director of UA's Arizona Research Laboratories. Cusanovich added that this is the first time members of the general public can join a genetics project of this scale.
Michael F. Hammer, a research scientist at UA's Arizona Research Laboratories and UA's BIO5 Institute, will analyze the general public's DNA samples. His team will trace people's lineages using markers encoded into DNA. The DNA samples will be analyzed in UA's Genomic Analysis and Technology Core (GATC), a facility providing genomic research services to public and private research institutions. GATC has the capacity to process up to 10,000 samples each month. The actual work load will depend on how many people join in the multi-national effort.
"For the first time people all around the world can learn about their genetic ancestry," said Hammer, a population geneticist. One of his specialties is deciphering prehistoric human relationships using genetics.
By comparing the genetic markers, the UA scientists' work will unveil new aspects of people's family trees, ones that are almost impossible to discover through traditional genealogical methods. In contrast to written historical records that can be lost or oral histories that can fall into disuse, the information stored in people's genes persists.
Cusanovich had his own DNA analyzed, which helped him trace his family to a time "when the crusaders were rolling through the Middle East." Many people conduct genealogical research, said Cusanovich, a UA professor of biochemistry and molecular biophysics and a professor in BIO5. "If you ask around here, you find that every tenth person is building a little family tree at home. They go to all the records and they're using Web sites to trace back their history."
The UA scientists will analyze a tiny fraction of the participants' genetic material: the y-chromosome, which is passed on from father to son, and mitochondrial DNA, which is passed on from mothers to their sons and daughters. This enables the researchers to decipher the characteristic genetic markers of both parental lineages.
UA is collaborating in a joint venture with Family Tree DNA, a company specializing in tracing ancestry using genetics. The company has been contracted to process the samples in the Genographic Project. Hammer is a consultant for and holds stock in the company. UA will not generate profits from the project.
People who wish to participate in the Genographic Project can buy a kit at $99.95 (plus shipping and handling) from National Geographic. The kit contains a swab to collect cells from the inside of the mouth and a tube to ship the sample to Family Tree DNA. The company then registers the sample and sends it to The University of Arizona for analysis. All samples are analyzed anonymously to protect individuals' privacy, and the information will be used only for the project. Participants can obtain their personal results on a Web site.
Participants who want to find out about a whole new set of relatives can do so by disclosing their names to Family Tree DNA and then plan their biggest family reunion ever.
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I'm an intermediate player looking for others who are also looking to improve their game, getting outdoors and having fun at the same time. I'm not concerned about your gender, age or playing level but hopefully you'll have a good attitude. My schedule is fairly flexible at the moment but I prefer afternoons and weekends.
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i am in a similar situation. I just want to get out and play again as i have not played in about 8 years but played extensively when i did. I live near Joyce station. I am looking to simply get back into it and enjoy some sunshine and excersise
hey man.
I can play tomorow Saturday 9-4-11 sometime around 3 or so if that is ok with you. The only problem i have is that i dont have a tennis racket as i must get mine mailed to me from back home. If you could give me a racket for the game i would be grateful. If not saturday i can play on sunday also! What tennis courts do you wish to play on? there are 2 courts near me at joyce station.
Call me on 604-512-6785 if that is ok.
Hi there Anthony!!
I have just arrived in Vancouver for a 2 months study period and cannot wait to have my first hit here (if rain allows it :)
I think I can consider myself an intermediate player as I've been practising for 3 years. When the subject is tennis, my time becomes very flexible and I play anytime after 4pm on weekdays. Weekends anytime!
I love havin fun on court.
If you or someone reading this get interested, please drop a line!!
Cheers guys!
Hey Joao,
Welcome to Vancouver! I'm sure you'll love it here, there are courts all over the city. I'll send you a pm so we can set up a time and place.
Thanks to those who have sent me a private message or added me as a friend. However, for some reason the site won't allow me to reply to or send a message. So, it might be helpful if you can include a number or email address where I can reach you.
© 2019 Created by Mark / The Mayor. Powered by


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Regular readers will remember me mentioning a design brief that my company Hyde Definition fulfilled last summer. It was to reduce the visual impact of a domestic wind turbine erected on private property in the UK, and the client wanted to be able to apply the design himself, in situ. Our website has recently been updated to include photographs of the turbine's camouflage scheme, kindly supplied by our client.
Realising that it is practically impossibly to conceal an object as large and obvious as a wind turbine against the constantly changing skyscape behind it, we chose to break up the shape and use different tones that will blend in some, but not all, conditions.
The bespoke design uses two shades of grey, plus white, applied over the black polycarbonate gearbox nacelle and triangular fin in a pixellated quadrilateral symmetry-axis disruption pattern. In plain speak, picture a flat image of the turbine head, with a line running along the centre of the nacelle, and a line running down the middle of the fin. Imagine that lines also extend inward from all the corners and join the central lines near their ends. These are the axes of internal symmetry, which is not a name for the next James Bond film, but is the central mass that needs to be broken up in order to deceive the eye, which we achieved by using square and rectangular serrated shapes in different sizes and orientations.


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As if the earlier remarks of LeSean McCoy were not indication enough, it's now clear that Eagles coach Chip Kelly has a serious and perhaps defining situation on his hands thanks to Riley Cooper's racist remark.
Via to Jeff McLane of the Philadelphia Inquirer, the anonymous players are beginning to sing, and they're not signing "Kum ba yah."
"I'll tell you one thing, if it was Andy Reid, he would have gotten more than a fine," one player said without using his name.
"The coaches are saying we should think team first, but this is just crazy," another said. "Was he thinking about the team when he said that?"
"If he's on the team, he's on the team," a player said. "Don't mean I have to like him."
The simple fact of the matter is, not every player on the roster is going to be as forgiving as quarterback Michael Vick, who is inclined to offer second chances having received a considerable one himself.
Kelly admitted concern with how the situation was going to play out, and whether his locker room would be divided.
"Yeah, there is a concern with that," Kelly said, via CSNPhilly.com. "Obviously, it's a very hot topic and that's why I encouraged our team [that] we've got to have some open communication so everybody knows what went on and what Riley is doing to atone for it."
The easy choice for Kelly to make would be to deem Cooper more trouble than he's worth, especially in light of the immediate anonymous backlash. If two or three guys are already chirping, more are in the background waiting to join the chorus, especially if they have no background with the third-year wideout.
And the question of value is a real one. Even with Jeremy Maclin out for the year, Cooper's a guy who has caught 46 passes in three seasons. There are players on the street who could offer that, if not more.
But keeping him, managing the situation, and reeling in the strong emotions could also strengthen Kelly's hold over the team.
That's worth more, especially for a first year coach, than any single player. But Kelly's going to have to handle this one delicately, because feelings are obviously raw, and they're not going to be smoothed over today or tomorrow.


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Diablo III is this week's long-anticipated release, but it is not the only one. Max Payne 3 also arrives on consoles, as does the Game of Thrones adaptation. It's a busy mid-May for both physical releases and downloadable titles.
• Diablo III (PC, Mac)
• Max Payne 3 (360, PS3)
• Game of Thrones (PS3, PC, 360)
• Hitman: Sniper Challenge (PC, XBLA, PSN)
• PixelJunk 4am (PSN)
• Sonic the Hedgehog 4: Episode II (PC, PS3)
• Asura's Wrath: Lost Episode 2 - The Strongest vs. the Angriest (PSN, XBLA)
• Dungeon Defenders: Quest for the Lost Eternia Shards - Part 3: Aquanos (PSN)
• JAM Live Music Arcade (PSN)
• Akai Katana Shin (360)
• Battleship (PS3, 360, 3DS, DS, Wii)
• Sonic the Hedgehog 4: Episode II (XBLA)
• JAM Live Music Arcade (XBLA)
• Dragon's Lair (XBLA)
• Resident Evil: Operation Raccoon City (PC)


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Featured News - Current News - Archived News - News Categories
WWE pay-per-view is returning to First Niagara Center for the first time in two years with a brand new landmark event. "WWE Battleground" will happen live in Buffalo on Sunday, Oct. 6, at 7:30 p.m.
See all your favorite WWE superstars, including:
John Cena
CM Punk
Randy Orton
Daniel Bryan
Dolph Ziggler
Rob Van Dam
The Shield
Tickets go on sale Saturday, Aug. 3, at 10 a.m., and are priced at $402.50, $302.50, $97.50, $72.50, $47.50 and $27.50, which include $2.50 facility fee. There will be a random handbill policy in effect. A limited number of handbills are available now.
Tickets can be purchased at the First Niagara Center Box Office and online at www.tickets.com. All dates, acts and ticket prices are subject to change without notice. For more information, or to charge by phone, call toll free at 888-223-6000.
Tickets are subject to applicable service charges (no service charge applies at First Niagara Center Box Office).
•NBC to air 'WrestleMania 29: The World Television Premiere' on Aug. 3
Event to feature epic rematch between the Rock and John Cena for the WWE Championship
For the fifth year in a row, WWE and NBC are joining forces to bring "WrestleMania" to network television. "WrestleMania 29: The World Television Premiere" will air on Saturday, Aug. 3, at 9 p.m., allowing fans to relive moments from the greatest sports entertainment spectacle in history.
The one-hour broadcast will feature the highly anticipated rematch between box office mega-star The Rock and WWE Superstar John Cena for the WWE Championship. "WrestleMania 29: The World Television Premiere" will feature this epic main event in its entirety for the first time on broadcast television.
On April 7 inside MetLife Stadium in East Rutherford, N.J., WWE's annual pop-culture extravaganza grossed more than $72 million as 80,676 fans from all 50 states and 34 countries were in attendance. "WrestleMania 29" broke the record for MetLife Stadium's highest-grossing entertainment event, which was broadcast around the world on pay-per-view in more than 100 countries and 20 languages.
For more information on "WrestleMania 29: The World Television Premiere," visit NBC.com's "Movies & Specials" site: http://www.nbc.com/movies-specials-more/.


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6832 RIDGE ROYALE Drive, Wrightstown WI 54126-9115 $69,000
Features of 6832 RIDGE ROYALE Drive, Wrightstown, WI 54126-9115
- Lots for Sale
- Status: Active
- Mailing City: Greenleaf
- County: Brown
- School Dist: Wrightstown Community
- High School: Wrightstown
- Property Taxes: $7
- Property Tax Year: 2018
- Listing Company: Coldwell Banker The Real Estate Group
Property Description for 6832 RIDGE ROYALE Drive, Wrightstown, WI 54126-9115
6832 RIDGE ROYALE Drive, Wrightstown, WI 54126-9115 - Fantastic Bargain for these Amazing home sites in Diamond View Estates located high on top of the Niagara Escarpment overlooking the Valley & Countryside. Parcels accommodate many different home styles and perk for Mound type septics p/seller. Restrictive Covenants on file. Wrightstown Schools and easy access to Green Bay & Appleton.
Land Features
- Waterfront/Access: N
|MLS Number
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|Sold Price
|Jul 27 2016 11:24AM
Estimated Monthly Payment
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Community Homes Near 6832 RIDGE ROYALE Drive
|Wrightstown Real Estate
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The information which is contained on pages with property data is obtained from a number of different sources and which has not been independently verified or confirmed by the various real estate brokers and agents who have been and are involved in this transaction. If any particular measurement or data element is important or material to buyer, Buyer assumes all responsibility and liability to research, verify and confirm said data element and measurement. Shorewest Realtors is not making any warranties or representations concerning any of these properties. Shorewest Realtors shall not be held responsible for any discrepancy and will not be liable for any damages of any kind arising from the use of this site.
REALTOR *MLS* Equal Housing Opportunity


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Let's be realistic. In a column like this I can only give you a hint of what you as a buyer need to do when it comes to outsourcing software development projects. However, it is amazing how many outsourcing agreements would benefit from the basic advice I present here. But note that "basic" means that there may be exceptions.
- Split the work into smaller, separately defined pieces that potentially can be given to different vendors.
- Separate work that is exploratory in nature from work that is mere production. Production can be calculated at a fixed price, whereas exploratory work can't reasonably be calculated in advance. For instance, don't ask for a fixed price until you know the key requirements (say 60-80 percent of all requirements), and until you know how you want it to be built (you must have an architecture that is implementable).
- It is beyond human ability to specify all requirements for software upfront. Don't accept a contractual model where all requirements have to be specified and agreed upon early. Even worse is to agree on requirements upfront and then pay an unspecified amount for each change. This is nothing less than horse dealer contracts.
- Outsourcing software development without an architecture is like asking someone to build a house without an architecture. You would never do that. However, for software, drawings are not enough. You need to make sure that the architecture can be realized. All important risks (performance, etc.) must have been eliminated. That requires you need some executable code - usually 5-10 percent of the final code must be in place before someone can calculate a fixed price.
- As for a house, you need to inspect at certain points to make sure that the work is on track. Inspection in our case must include executable code to be meaningful.
Now, this is not easy to do. Still, this is just the basics. For large outsourcing projects such as building an enterprise wide SOA system, the required competencies are much higher.
- You need to be able to split the work among several subcontractors. Thus, you need to set a building standard. Otherwise different vendors will deliver non-compatible software. It is not enough to specify what platform to use, but you need to specify how to make drawings (UML for example), what design practices to use (use cases for example), when inspection needs to happen and more.
The general advice is to split the work in smaller manageable pieces with fast deliveries. Think big, but buy small! Western companies outsourced big M$ projects to India. Japanese companies are not giving up control that easily. Their outsourcing contracts to China are in the order of $100k. Many western companies are now taking back (insourcing) their software to maintain and develop it at home. The new strategy is to insource the business critical applications, but outsource less critical software. Reflecting on this, it seems we are going back to where we were before the outsourcing frenzy started.
Again, if you don't have this competence or you cannot get it, don't even bother to outsource your software development. And, competency is not enough. You need to be smart!


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Washington D.C., Jan 23, 2013 / 05:02 pm ().- Pro-life politicians from across the country reflected on four decades of legal abortion in America, offering prayers and the promise of renewed efforts to build a culture of life.
Newly-elected Rep. Ann Wagner (R-Mo.) said that she is "heartbroken" by all the lives that have been devastated by abortion, but also "hopeful and inspired" by the young people who represent the future of the pro-life movement.
Wagner spoke on the House floor on Jan. 22, the 40th anniversary of the Roe v. Wade Supreme Court decision that effectively legalized abortion throughout America.
She lamented the 1973 ruling as "a decision that has done so much harm to the moral landscape of our nation."
Wagner explained that as a mother, "the sanctity of life is very cherished and personal to me." She recalled traveling to Washington, D.C. 23 years ago to participate in the March for Life, while pregnant with her second son.
"I knew that it was not enough to simply say that I was pro-life," she said. "I literally had to walk the walk."
Wagner was one of numerous legislators from both major political parties who spoke out in support of life on Jan. 22, voicing sorrow over four decades of legalized abortion and pledging continued action to foster respect for all human life.
"While we mourn for the babies and their mothers, we in the pro-life movement must rededicate ourselves to prayer and action to protect life," said Rep. Dan Lipinski (D-Ill.).
In a statement provided to CNA, he explained that defenders of life must "not only focus on changing our nation's laws, but also changing hearts and minds, and caring for expectant mothers and their babies."
The congressman said that he is "uplifted by the participation of so many young people" in the March for Life each year. This year's march, scheduled for Jan. 25, is expected to draw hundreds of thousands of participants, including a strong youth presence.
"With God's help, they are key to moving our nation away from the culture of death to embracing a culture of life," Lipinski stressed.
Dozens of pro-life lawmakers observed the anniversary of Roe v. Wade on social media sites.
"America knows the collective pain of abortion is a heavy burden no free and prosperous nation can carry forever," wrote Rep. Marsha Blackburn (R-Tenn.) on Twitter.
"My belief in the sanctity of human life has deepened through my experiences as a mother, a Christian, and a nurse," Rep. Renee Ellmers (R-N.C.) posted on Facebook. She added that the anniversary of Roe v. Wade is a reminder "that every life is a precious gift from God."
Multiple legislators quoted former President Ronald Reagan, who reflected on the 10th anniversary of Roe v. Wade that "(w)e cannot diminish the value of one category of human life – the unborn – without diminishing the value of all human life."
Senator Marco Rubio (R-Fla.) called the 1973 decision "one of America's most blatant instances of judicial activism."
In an online statement, he mourned the loss of the millions of children who "have been denied the chance to celebrate a birthday, begin kindergarten or go on to contribute their God-given talents to our world."
Rubio pledged to continue fighting for the unborn in the U.S. Senate.
"As with many of our nation's most important debates," he added, "the battlefield of this issue is in the hearts and minds of the American electorate, and I pray that we can one day live in a society that fully cherishes every life from conception until death."
Rep. Diane Black (R-Tenn.), a former nurse, noted all the progress that women have made in modern society.
Black is one of several pro-life legislators who will address the crowds gathered for the March for Life.
Speaking at a Jan. 22 press conference marking the 40th anniversary of Roe v. Wade, she observed that millions of unborn women "are not here to benefit from the progress we have made and share in our hopes and dreams for the future."
"We press on with the hope that one day we will live in a country where each and every life – both born and unborn – is respected, valued and given the opportunity to pursue his or her dreams," she said.
Tags: Abortion, Roe v. Wade
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US Common Core State Standard Math HSS-ID.A.4
Demonstrations 1 - 12 of 12
Description of Standard: Use the mean and standard deviation of a data set to fit it to a normal distribution and to estimate population percentages. Recognize that there are data sets for which such a procedure is not appropriate. Use calculators, spreadsheets, and tables to estimate areas under the normal curve.


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Anonymous User wrote:Anonymous User wrote:Just checking to see if you still look at this site. If so, I have a few questions. Thank you. Ed
I'm the anon you quoted above, so ask away.
(FWIW, a lot of that is still the same, but I have more investigative stuff going on now that I'm not a newbie, and my hours, well, they've gotten worse. )
Can you PM me please so I can ask a few questions? Thanks


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North Carolina tax lists – definition of white and black "polls"
The poll tax was imposed on males and slaves in every household.
It was started in 1715 by the General Assembly and applied to all males over the age of 16 "white poll" and all slaves, male and female, over the age of 12 "black poll", were also taxed at this time.
This tax was modified in 1777 and 1784 to include property owned.
In 1784, the black poll was changed to include freeman and male servants over the age of 21 (with males over 45 being exempt after 1835) and male and female slaves between the ages of 12 and 50.
In 1801, the poll tax was changed to exempt males over the age of 50 and in 1817, the age was dropped to 45.
After the abolition of slavery in 1868, the tax was changed to all males between the ages of 21 and 50 until the poll tax was ended in 1970.
Source: "North Carolina Research: Genealogy and Local History, 1996", by Helen Leary, pages 231-232.
Filed under: North Carolina | Tagged: North Carolina, Tax | Leave a comment »


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Entertainment can be distinguished from other activities such as education and marketing even though they have learned how to use the appeal of entertainment to achieve their different goals.Although, every individuals have different preferences in entertainment, most forms are recognisable and familiar.So,if your having a hard time for yourself.The following list here are some example of entertainment that can help and entertain you.
Rockin' Baja Lobster - Coastal Cantina Gaslamp Quarter
Societe Brewing Company
Bub's At The Ballpark
Cuban Cigar Factory
Noel-Baza Fine Art
Adam's Steak 'n' Eggs
San Diego Art Institute
London's West End
Kearny Mesa Recreation Center
Morley Field Playground
Sky High Sports
SeaWorld San Diego
Mentalist and Magician Kevin Viner
Military Press
The Westin San Diego Gaslamp Quarter
Cafe Sevilla of San Diego
Sanchez Taekwondo Academy
Maritime Museum of San Diego
Martinis Above Fourth | Table + Stage
Corvette Diner
Belmont Park
Sheraton San Diego Hotel & Marina
Lestat's Coffee House
Balboa Theatre
Reuben H. Fleet Science Center
Pro Motion Entertainment
The Field Irish Pub
Nickel City
Hotel del Coronado
360 Motorcycle Adventures
The Shout! House
USS Midway Museum
Paradise Point Resort & Spa, A Destination Hotel
The San Diego Museum of Art
Lamb's Players Theatre
Gallagher's Irish Pub
Dave & Buster's
Whaley House Museum
San Diego Natural History Museum
San Diego Museum of Man
Kansas City Barbeque
The Casbah
House of Blues San Diego
San Diego Symphony
Museum of Photographic Arts
Timken Museum of Art
San Diego Hall of Champions
Spreckels Theatre
Lips Restaurant
Cygnet Theatre
W San Diego
Mingei International Museum
San Diego Model Railroad Museum
The Old Globe
San Diego Zoo
Viejas Arena
Marston House Museum & Gardens
For more results of Entertainment in San Diego,California click here: http://us.wowcity.com/california/sandiego/?what=Entertainment
Entertainment is a form of activity that holds the attention and interest of an audience, or gives pleasure and delight. It can be an idea or a task, but is more likely to be one of the activities or events that have developed over thousands of years specifically for the purpose of keeping an audience's attention.However,the list here are mostly some events and places that can help you in your life if your seraching for fun and pleasures..


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Friday, January 27, 2012
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PHOENIX (Friday, January 27, 2012)--Arizona Attorney General Tom Horne today announced the arrests of 14 of 15 suspected members of a large-scale marijuana and cocaine trafficking organization. This organization has smuggled over 19.1 kilograms of cocaine and 2,952 pounds of marijuana into the United States since December of 2010 with a Tucson, Arizona street value estimated to be between $2,631,600 and $2,126,400.
This criminal enterprise has been active for more than ten years in smuggling large amounts of marijuana and cocaine into the United States through the Nogales Port of Entry. The organization was utilizing tracker trailer dump trucks with scrap metal as cover, backpackers, and vehicles with hidden compartments to smuggle the marijuana and cocaine multiple times per week, and smuggle large amounts of US currency back into Mexico. Once in the United States, the marijuana and cocaine were being stored at various Nogales, Rio Rico, Tucson, and Phoenix area stash houses.
"This is yet another in a growing list of examples why the Arizona border with Mexico is not secure," Horne said. "For this criminal operation to exist for the better part of a decade trafficking millions of dollars worth of poison into Arizona is outrageous and helps to define the critical nature of this problem. The level of violent criminal activity near the border and throughout much of Arizona at large is a direct result of the drug trade, and it simply cannot continue. In the meantime, the policy of the federal government remains to peddle the fiction that the border is as secure as it has ever been. It clearly is not, and I reiterate my call to the administration to do more to address this crisis."
On December 10, 2010, law enforcement seized 2,873 pounds of marijuana in a belly-dump trailer pulled by a tractor. On May 14, 2011, law enforcement seized 77.7 pounds of marijuana hidden in the tires of a truck. On May 31, 2011, law enforcement seized $15,300 in U.S. currency of illegal drug proceeds hiding in a vehicle during a traffic stop. On June 11, 2011, law enforcement seized 10 kilograms of cocaine hidden in a car. On June 15, 2011, law enforcement seized of 9.1 kilograms of cocaine hidden in a false compartment in a car. On July 21, 2011, law enforcement seized 5 total packages of cocaine, weighing 5.644 oz (1/3 lbs). On September 29, 2011, law enforcement seized 6 pounds of marijuana believed to be a sample of a 300 pound load.
On January 26, 2012, simultaneous search and arrest warrants were executed on suspected members of the drug trafficking organization and their stash houses.
The 15 suspected members were indicted on charges ranging from Illegally Conducting an Enterprise, Conspiracy, Transportation of Marijuana for Sale; Transportation of Cocaine for Sale; Money Laundering; Use of a Wire Communication or Electronic Communication in a Drug Related Transaction or to Facilitate the Violation of any Felony Provision; and Weapons Misconduct. The remaining defendants are not being identified at this time, because grand jury secrecy requires their names be withheld until they have been served.
Agencies working in cooperation with the Drug Enforcement Administration and U.S. Immigration and Customs Enforcement's Homeland Security Investigations Strike Force are the U.S. Border Patrol, U.S. Marshal's Service, Nogales Police Department, Tucson Police Department, Department of Public Safety, and the Arizona Attorney General's Office. The case is being prosecuted by Assistant Attorney General Nanette Morrow. These charges are merely allegations, and the defendants are presumed innocent until and unless proven guilty.Indictment charges include:


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Israel News - Stay Informed, Pray Informed
It would seem counterproductive to achieving a genuine peace to set free those who had so brutally done all they could to ensure peace found no footing.
And yet, the Palestinian Authority last week was adamant it would not rejoin US-backed peace talks with Israel until the latter agreed to loose 104 terrorists jailed for either murdering or attempting to murder Israeli Jews.
Under normal circumstances, such a demand would leave those on the losing end of that equation scratching their heads.
"It's hard for many Israelis to grasp why their partners for peace demand that the murderers of children be freed," wrote Avi Mayer, the Jewish Agency's director of new media, on his Twitter account.
But after nearly two decades of a failed peace process, most Israelis know better. They know the Palestinian leadership isn't looking for a genuine peace. They know that Mahmoud Abbas and his PLO remain dedicated to the movement's founding principles of never accepting Israel and working continuously, through any means, to bring about the eventual demise of the "Zionist entity."
So, why does Israel continue to play this game? Why is it that every few years Israel repeats what it knows is the wasted gesture of setting free blood-soaked killers?
Israeli Interior Minister Gideon Saar had the answer at Sunday's cabinet meeting, where he passionately argued in favor of the prisoner release despite admitting nothing good could come of it.
"I don't believe we can get a peace agreement with the Palestinians, but I want to preserve Israel's international standing," Saar was quoted as saying by Ha'aretz reporter Barak Ravid. The minister continued: "If we don't vote for the prisoner release our last few friends around the world might not support us anymore in the UN."
Sadly, this is the kind of groveling to which Israel's leaders have been reduced.
As with every previous release of jailed terrorists, this will send a clear message that even the most savage acts of violence against even the most innocent of Israelis will not earn one lasting punishment, but rather a hero's status. And terrorists will be emboldened to continue on their destructive path. And peace will remain elusive.
Want more news from Israel?
Click Here to sign up for our FREE daily email updates
For Information & Reservations:
E-Mail: email@example.com
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We are happy to announce that we have just launched our first certified organic crib bedding collection. Certified to be grown without the use of petroleum based fertilizers or harsh chemicals, our natural organic collection is down to earth and comes in the sweet earthy shade of "raw sugar".
The organic crib sheets are offered at the nice price of $24 and have been integrated into our new Modern Fern collection. The organic changing pad cover is offered at $29.00.
Whether you are wishing to ensure that only the highest quality fabrics touch your baby's skin or you want to have a completely green household, we now have a comprehensive offering of organic crib bedding, portable crib bedding, toddler bedding and nursery decor to complete your nursery.
Stay tuned for the introduction of new organic colors in the future.


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Apple today shipped iOS 7.1, the first major update since its newest mobile operating system launched in September 2013.
The update, which was made available Monday morning, includes support for CarPlay, the in-car, hands-free user interface (UI) for the iPhone, which debuted last week.
According to Apple's release note, other enhancements in iOS 7.1 ranged from several for Siri, the voice-activated and voiced personal assistant, to additions within iTunes Radio, Apple's free, ad-supported music streaming service that kicked off with iOS 7 last fall.
Several stability and reliability bugs were addressed in the update, including one that improved Touch ID fingerprint recognition on iPhone 5S smartphones, and a vague pledge of "improved performance for iPhone 4," the oldest of Apple's handsets able to run the operating system.
Customers with the iPhone 4 -- the model that launched in June 2010 -- have griped on Apple's support forum and elsewhere that iOS 7 was sluggish, or worse, on their devices, a common complaint for all Apple's mobile OSes on the oldest hardware.
iOS 7.1 also fixed the bug that caused crashes of the home screen, Apple said. That bug has plagued users since September, and in January the Cupertino, Calif. company promised a fix was coming.
Apple also expanded the list of supported countries for iCloud Keychain, the password management and synchronization service; gave users a by-month view in the Calendar; and continued to tweak the iOS 7 UI, which was Apple's first visual overhaul since the 2007 iPhone debut.
With 172 days between iOS 7 and 7.1, the update arrived later than those for previous editions of the operating system. For iOS 3 through iOS 6, the average length of time between the initial release and the first major update was 117 days, while the median was 109 days.
Apple patched 41 vulnerabilities in iOS 7 with Monday's update, including 19 in WebKit, the open-source browser engine used by Safari. Of those 19 WebKit flaws, 8 were found by Google security engineers working on the Chrome team.
iOS 7.1 can be downloaded over the air or through iTunes. From an iPhone, for instance, users must tap the "Settings" icon, then the "General" button on the resulting screen. Tapping "Software Update" will kick off the update process. The operating system runs on iPhone 4 and later, iPad 2 or later, iPad mini or later, and the fifth-generation iPod Touch, which went on sale in October 2012 (32GB and 64GB models) and May 2013 (16GB).
Gregg Keizer covers Microsoft, security issues, Apple, Web browsers and general technology breaking news for Computerworld. Follow Gregg on Twitter at @gkeizer, or subscribe to Gregg's RSS feed. His email address is [email protected]


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Difference between revisions of "Spatial Ecology 2009"
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Sarah Treanor
Sarah Treanor
Revision as of 21:50, 8 September 2009
Seminar in Spatial Ecology (Fall 2009)
Professor John Silander
A forum to present and discuss a variety of issues related to modeling or quantifying spatial and temporal patterns of species distributions and ecological or evolutionary processes. We will meet once a week. Graduate students will present and discuss some of their on-going research or provide an opportunity to present research plans, ideas, or results, and to get feedback from the group. Other meetings may be devoted to reading current or classic papers on spatial-temporal patterns and processes in ecology and evolution.
We meet Tuesdays from 2:30 to 3:30 or so in the Bamford Room (TLS 171b)
September 1
Professor Sheng Qiang, Nanjing Agricultural University in China will talk briefly about his research on the distribution of Solidago canadensis species complex (which is invasvie in China), and genotypic variation therein, and what he hopes to accomplish during his visit here.
September 8
Cory Merow (CA Models)
September 15
John Silander discussing two papers by Catherine Graham (Stony Brook)
September 22
Sarah Treanor
September 29
October 6
October 13
October 20
October 27
Adam Wilson ~ Post-fire biomass accumulation and climate
November 3
Jeb Stevens
November 10
Brian K
November 17
Jenica Allen
November 24
Thanksgiving Break (no meeting)
December 1
Erin Fox


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This is standard for North, compare 2011 vs 2012 bars as well - prize went up a lot (30-40eu at least I think) and the only thing that changed on the bar was the color, nothing more.
I wonder if the kites will go up 50-70eu as well as they did this year.
Guess it's time to switch to Ozone or Slingshot.


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Spartanburg, SC-- Ashley Arff and Alaina Smith led the Valkyries to thier first win of the season. Converse improves to 1-12 on the season (1-8 in Conference Carolinas). Coker falls to 4-7 for the season (3-3 in conference play).
Arff grabbed a total of 14 points, 5 rebounds, 1 assist, 1 block, and 2 steals. Smith along with Brandy Williams and Sydney Brown all contributed 12 additional points apiece. Smith also pulled down 10 total rebounds for the night and Williams grabbed 4 steals.
Converse established an early 10 point lead that eventually fell to traded shots withplenty of fouls. The exciting half was marked with the largest lead of 16 points and 2 ties. Although Coker fought to keep up, the half ended with Converse leading by 12 (37-25). The second half showcased some cautious play by both teams as the majority of players found themselves in trouble of fouling-out.
The Valkyries held the edge from layup points (34-12) and points-in-the-paint (40-14) which largely contributed to the win as Coker edged out Converse at the charity stripe (75%-74%), 3-point shooting (18% - 14%), and rebounding (54%-46%). "We finally found a way to take advantage of opportunities such as putbacks, easy layups, and safe shooting. If we continue to play this hard, I have no doubt we'll see the same results," said Joanna Tincher, head coach for the Valkyries.
The Cobras were led by Kiesha Beavers who contributed 18 total points. Jessica Hayes managed to pull down 9 total rebounds. The Valkyries play again on Saturday at 2:00pm at Erskine, while Coker travels to Belmont Abbey.


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10 reviews
Haus Sun Valley Lodge Zermatt
Welcome to the Sun Valley Lodge, which has been run by our family for two generations! Ideally located: 200 m to the Matterhorn Glacier Paradise and bus stop, 5 min. to a grocery store and a bakery, and 10 min. to the village centre. 7 flats and 6 studios equipped with kitchens, living rooms with TV, radio, wireless network and phone, bedrooms and bathrooms. Balconies offering breath-taking views of the famous Matterhorn. Other facilities: storage for skis and shoes, lift. Enjoy some of the best Swiss dishes in our restaurant LA TAVERNE. The Sun Valley Lodge is eco-friendly! (pellet fuel, solar panels)
Check in: from midday on Check out: 9 - 9.30 a.m. house can be reached by the public taxi
Haus Sun Valley Lodge
Schluhmattstrasse 97, 3920 Zermatt
Phone +41 27 966 39 50
lift not-smoking free-wifi


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Dorothy E. Roberts
George A. Weiss University Professor of Law and Sociology and the Raymond Pace and Sadie Tanner Mossell Alexander Professor of Civil Rights
Dorothy Roberts, an acclaimed scholar of race, gender and the law, joined the University of Pennsylvania as its 14th Penn Integrates Knowledge Professor with joint appointments in the Departments of Africana Studies and Sociology and the Law School where she holds the inaugural Raymond Pace and Sadie Tanner Mossell Alexander chair. She is also founding director of the Penn Program on Race, Science & Society in the Center for Africana Studies.
Her pathbreaking work in law and public policy focuses on urgent contemporary issues in health, social justice, and bioethics, especially as they impact the lives of women, children and African-Americans.
- Family Law
- Criminal Law
- Bioethics
- Civil Rights Law
- Juvenile Justice
FATAL INVENTION: HOW SCIENCE, POLITICS, AND BIG BUSINESS RE-CREATE RACE IN THE TWENTY-FIRST CENTURY (The
New Press, 2011).
[Available Here]
SEX, POWER, AND TABOO: GENDER AND HIV IN THE CARIBBEAN AND BEYOND (with Rhoda Reddock, Dianne
Douglas & Sandra Reid, Ian Randle Publishers, 2009)
[Available Here]
FRUG'S WOMEN AND THE LAW (with Libby Adler et al., Foundation Press, 4th ed., 2008; 3rd ed., 2004; 2nd ed., 1998).
KILLING THE BLACK BODY: RACE, REPRODUCTION AND THE MEANING OF LIBERTY (Random House/Pantheon, 1997; Vintage paperback, 1999).
Articles and Book Chapters
Race, Care Work, and the Private Law of Inheritance, 40 LAW & SOC. INQUIRY 511 (2015).
Reconciling Equal Protection Law in the Public and in the Family: The Role of Racial Politics, 162 U. PA. L. REV. ONLINE 283 (2014).
Law, Race, and Biotechnology: Toward a Biopolitical and Transdisciplinary Paradigm, 18 ANN. REV. L. & SOC. SCI. 149 (2013)
Movement Intersectionality: The Case of Race, Gender, Disability, and Genetic Technologies, 10 DUBOIS REV. 313 (2013) (with Sujatha Jesudason).
Prison, Foster Care, and the Systematic Punishment of Black Mothers, 59 UCLA L. REV. 1474 (2012).
Debating the Cause of Health Disparities -- Implications for Bioethics and Racial Equality, 21 CAMBRIDGE Q. HEALTHCARE ETHICS 332 (2012).
Race, Gender, and the Conflation of Biological and Social Issues, 9 DUBOIS REV. 235 (2012) (book review).
The Social Context of Oncofertility, 61 DEPAUL L. REV. 777 (2012).
What's Wrong with Race-Based Medicine? Genes, Drugs, and Health Disparities, 12 MINN. J. L. SCI. & TECH. 1-21 (2011) (2010 Dienard Memorial Lecture in Law & Medicine).
Collateral Consequences, Genetics Surveillance, and the New Biopolitics of Race, 54 HOW. L.J. 567 (2011).
The Paradox of Silence and Display: Sexual Violation of Enslaved Women and Contemporary Contradictions in Black Female Sexuality, in BEYOND SLAVERY: OVERCOMING ITS RELIGIOUS AND SEXUAL LEGACIES 41 (Bernadette J. Brooten, ed., Praeger Press 2010).
[Available Here]
Race and the New Biocitizen, in WHAT'S THE USE OF RACE 259 (Ian Whitmarsh & David Jones, eds., MIT Press, 2010).
[Available Here]
The Social Immorality of Health in the Gene Age: Race, Disability, and Inequality, in AGAINST HEALTH 61 (Jonathan Metzl & Anna Kirkland, eds., NYU Press, 2010).
[Available Here]
Race, Gender, and Genetic Technologies: A New Reproductive Dystopia?, 34 SIGNS 783 (2009).
Margaret Sanger and the Racial Origins of the Birth Control Movement, in RACIALLY WRITING THE REPUBLIC: RACISTS, RACE REBELS, AND TRANSFORMATIONS OF AMERICAN IDENTITY 196 (Bruce Baum & Duchess Harris, eds., Duke University Press, 2009).
[Available Here]
Sick and Tired: Working Women and Their Health, in THE SHRIVER REPORT: A WOMAN'S NATION CHANGES EVERYTHING 122 (Heather Boushey & Ann O'Leary, eds., The Center for American Progress, 2009). (with Jessica Arons)
[Available Here]
Is Race-Based Medicine Good for Us?: African-American Approaches to Race, Biotechnology, and Equality, 36 J.L. MED. & ETHICS 537 (2008).
Torture and the Biopolitics of Race, 62 U. MIAMI L. REV. 229 (2008).
The Social and Moral Cost of Mass Incarceration in African American Communities, 56 STAN. L. REV. 1271 (2004).
The Genetic Tie, 62 U. CHI. L. REV. 209 (1995).
Punishing Drug Addicts Who Have Babies: Women of Color, Equality, and The Right of Privacy, 104 HARV. L. REV. 1419 (1991).
More publications can be found here.
Penn Law – George A. Weiss University Professor of Law and Sociology and the Raymond Pace and Sadie Tanner Mossell Alexander Professor of Civil Rights (2012- )
Northwestern – Kirkland & Ellis Professor of Law (2002-12); professor (1998-02). Joint appointments: Institute for Policy Research, Weinberg College of Arts and Sciences in African American Studies and Sociology
Visiting Faculty/Fellow – Harvard, Stanford, Fordham, Northwestern, Penn Law
Fulbright Fellow, Center for Gender and Development Studies, University of West Indies, Trinidad & Tobago (2002-03)
- Critical Race Theory
- Criminal Law
- Current Controversies in Child Welfare Policy
- Family Law
- Race, Biotechnology and Law in the Gene Age


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Lufthansa Systems renewed its contract with XL Airways France covering use of its flight management system database for another three years.
Subscribe to Access this Entire Article
"Other News - 05/28/2009" is part of ATW Plus, our online premium membership. Subscribing will provide you access to exclusive news, carefully researched airline financial, fleet and traffic data, plus the option to receive our popular, award-winning print magazine. To learn more, click here. If viewing via ATW Mobile, please login and click "Read web article" to view fully. Questions? firstname.lastname@example.com.


text: (ISPConfig Version: 188.8.131.52 on Ubuntu 10.04) I need to make a MySQL database accessible to a remote server on the LAN. ISPConfig is running on 192.168.108.129. I check the "Remote Access" checkbox and enter the IP of the remote server, 192.168.108.140, in the "Remote Access IP" textbox. I set the bind address in /etc/mysql/my.cnf Code: bind-address = 0.0.0.0 I open port 3306 on the firewall for the remote server. Port 3306 appears open if I test it with nmap on the remote server. So far so good. However I can't access the database from the remote server. Code: mysql -h 192.168.108.129 c3songs -u c3songs -p Enter password: ERROR 1130 (HY000): Host '192.168.108.140' is not allowed to connect to this MySQL server If I log into mysql as root on the ISPConfig server then there doesn't appear to be a c3songs user created for the 192.168.108.140 address. Code: mysql> select Host,User from mysql.user; +--------------------+------------------+ | Host | User | +--------------------+------------------+ | 127.0.0.1 | root | | ispconfig.example.com | root | ...(abbreviated, other users listed here) | localhost | c3songs | ... (abbreviated, other users listed here) | localhost | ispconfig | | localhost | root | +--------------------+------------------+ 19 rows in set (0.00 sec) Is ISPConfig doing anything to enable remote access? I can't see any evidence of it in the database unless I am missing something. If I set the logging level to debug and run server.sh at the command line I see the following related output when I enable external dB access... Code: 03.11.2012-09:35 - DEBUG - Found 1 changes, starting update process. /usr/bin/fail2ban-client /sbin/iptables /sbin/ip6tables 03.11.2012-09:35 - DEBUG - Calling function 'db_update' from plugin 'mysql_clientdb_plugin' raised by event 'database_update'. 03.11.2012-09:35 - DEBUG - Changing MySQL remote access privileges for database: c3songs 03.11.2012-09:35 - DEBUG - Processed datalog_id 254 If I add permissions manually then I can access the database from the remote server. But shouldn't ISPConfig be doing that for me? This works... Code: GRANT ALL PRIVILEGES ON c3songs.* To 'c3songs'@'192.168.108.140' IDENTIFIED BY '*****';


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License: Permission is granted to copy, distribute and/or modify this document under the terms of the GNU Free Documentation License, Version 1.3 or any later version published by the Free Software Foundation; with no Invariant Sections, no Front-Cover Texts, and no Back-Cover Texts. A copy of the license is included in the source of this documentation, and is available here online: http://www.gnu.org/licenses/fdl.html.
|Revision History
|Revision HEAD@0c7d1fb3
|2018-11-05 10:29:13
|Version 2.31
Table of Contents
List of Figures
List of Tables
List of Examples


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Išplėstinė statistika
Pilna informacija apie pelną ir pritrauktus klientus realaus laiko režimu
Types of partnership
InstaForex offers its partners various forms of cooperation.
The types of partnership with InstaForex vary in the way of attracting clients. At the beginning, the standard affiliate commission is the same with all types of the affiliate program; it amounts to 1.5 pips from a trade of a referred customer. A partner should choose a type of the affiliate program depending on his business. Every partner can use different methods to attract new clients with one affiliate account
If you are interested in any form of cooperation with the international broker InstaForex, please contact a manager of InstaForex Partner Relations Department in a preferable way:
Partner Relations Department
Operating hours: 7:00-16:00 (GTM 00)
Reklaminė medžiaga
Kodėl InstaForex


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Which version of IIS am I using?
Our Web & Classic Windows shared hosting accounts offer multiple versions of IIS, so you might need to know which version your account is set up to use.
To find your version of IIS
- Log in to your GoDaddy account.
- Click Web Hosting.
- Next to the account you want to use, click Manage.
- In the Server Details area, click Show Details.
Your IIS Version displays.


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How I Met Your Mother: Season 7 Photo Gallery
The multi-award-winning How I Met Your Mother returns for its seventh season on DVD on October 15, 2012. Starring Jason Segel (Forgetting Sarah Marshall, The Muppets), 2012 People's Choice Award-winner Neil Patrick Harris and Alyson Hannigan (American Pie), How I Met Your Mother is a comedy about Ted (Josh Radnor) and how he fell in love. Narrated by Ted's future self as he tells his children the story of how he met their mother, How I Met Your Mother has garnered praise from critics and fans alike throughout its incredible 7-year history. View photos from Season 7…
Roll your mouse over the left and right-hand sides of the image and then click to view more pictures.
Recent Galleries:
- Bright (Will Smith/Joel Edgerton) - First-look Photo Gallery
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- Sexiest TV Actresses of 2013
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- Peaky Blinders (Cillian Murphy/Helen McRory) Character Posters
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