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Funding Supports Crowd-Sourced Study of Allergies and Asthma, Development of Sequencing Quality Metrics; and Enhancing the 23andMe Research Engine
MOUNTAIN VIEW, Calif., Dec. 4, 2012 /PRNewswire/ -- 23andMe has received grants totaling $573,000 from the National Institutes of Health (NIH) to support three projects that utilize 23andMe's unique web-based research platform. These include projects to better understand the genetics of allergies; to assess accuracy of new sequencing technologies in clinical applications; and to develop tools that will take advantage of the genotypic and phenotypic information in the 23andMe database to further accelerate the pace of human genetic research.
"These NIH grants recognize the ability of 23andMe's unique, web-based research platform to accelerate our understanding of human genetics," said Anne Wojcicki, co-founder and CEO of 23andMe. "23andMe is pleased to bring public funding to bear on data and research driven by the public - our more than 180,000 customers."
The first of the grants will support genome wide association studies (GWAS) to discover genetic factors affecting allergic disease risk, and to assess gene environment interactions, as well as treatment responses. Asthma and allergies are extremely common, affect one in five Americans, and represent a substantial public health burden. GWAS of complex traits with both genetic and environmental contributions - such as allergies - are most effective when a large cohort is used in the study. The 23andMe research cohort includes more than 25,000 individuals reporting one or more allergies, more than 8,000 reporting an asthma diagnosis and more than 5,000 reporting having eczema. In addition, the 23andMe research cohort includes more than 100,000 individuals serving as controls.
Identifying genetic associations improves understanding of disease mechanisms in the body and can inform work towards improved diagnostics and treatments of allergic conditions.
"This grant will enable 23andMe to effectively partner with leading experts and researchers in the genetics of asthma and allergies," said Principal Scientist at 23andMe, David Hinds, Ph.D. "Top experts will work together and with our data set seeking to discover genetic variants associated with allergies and asthma."
23andMe will also be investigating error rates from next-generation sequencing technologies to help define data-quality metrics and technical specifications to support a sequencing-based Personal Genome Service®. This project was informed by the June 2011 FDA Public Meeting, "Ultra High Throughput Sequencing for Clinical Diagnostic Applications- Approaches to Assess Analytical Validity." In this project, 23andMe will focus on the accuracy of technology used to sequence 150 exomes, including 50 new exomes sequenced for this project, and 100 whole genomes.
"Novel genetic sequencing technologies are emerging rapidly, and before they can be broadly adopted the accuracy of their results must be validated, whether viewed by a clinician or by individual consumers," said 23andMe Founding Scientist Brian T. Naughton, PhD.
Naughton, principal investigator for this project, will oversee sequencing of 50 exomes known to carry disease-associated variants. This project will work toward creating a pipeline for next-generation sequence annotation that combines stringent quality control based on genotyping array and Sanger sequencing data; manually curated data from human genetics literature; and computational analysis of variants of unknown significance.
Principal investigator Nicholas Eriksson, PhD. will lead the development of tools to expand the utility of the 23andMe database, which includes phenotypic and genetic data from more than 180,000 customers. This project will measure and improve the reliability of self-reported data, analyze and organize survey responses for hundreds of new traits, and will extract more robust data to demonstrate the feasibility of the web-based approach to studying a broad range of conditions. This effort will establish the foundation for development of new surveys and data collection tools to support longitudinal studies and prepare for the depth of genetic data associated with whole-genome sequencing.
"A research engine will enhance not only research outcomes from 23andMe efforts," said Dr. Eriksson, "but also the research value of the data for clinical and pharmaceutical partners to identify causes, diagnoses and treatments for genetically based conditions and accelerate the translational process of moving research discoveries to practical applications for patients."
The projects described are supported by NIH Awards 1R43HL115873-01 from the National Heart, Lung, and Blood Institute, and 1R43HG006976-01 and 1R43HG006981-01 from the National Human Genome Research Institute. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Human Genome Research Institute, the National Heart, Lung and Blood Institute or the National Institutes of Health.
About 23andMe
23andMe, Inc. is the leading personal genetics company, dedicated to helping individuals understand their own genetic information through DNA analysis technologies and web-based interactive tools. The company's Personal Genome Service® enables individuals to gain deeper insights into their ancestry and inherited traits. The vision for 23andMe is to personalize healthcare by making and supporting meaningful discoveries through genetic research. 23andMe, Inc., was founded in 2006, and the company is advised by a group of renowned experts in the fields of human genetics, bioinformatics and computer science. More information is available at www.23andme.com.
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text: Hi ! I am back with a problem, I need to simplify the connection to ISPC like in CPanel, I give a link and when they click, They are redirected to the panel and they are connected. Of course it has to pass through a page that creates cookies or something like that. Any idea to how to do with the API or something else ?


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Booking a ticket at FareHawker is very simple, so you have more time for the important things in life. All you have to do when looking for a flight is select route for Bangalore to Guangzhou and on which travel dates. FareHawker does the rest by sorting through the available flights and cheapest fares for those dates. Our results page will then display the available flights, cheapest prices, times and flight duration for your search. At that point, you just have to decide which of those tickets you wish to book, then enter the passenger and payment details, confirm, and pay for your tickets. It's that simple! All the tools and resources you need to make the most of your online booking and planning we guarantee the best pick. From the lowest fare to charter flight or even group booking we have it all round the year, book your next flight for best airfare.
BLR Airport Address
Bengaluru International Airport
KIAL Rd, Devanahalli, Bengaluru, Karnataka 560300, Bangalore
Contact Number:-  1800 425 4425
Country:-  India
Continent:-  Asia
CAN Airport Address
Baiyun, Guangzhou, Guangdong, China, Guangzhou
Contact Number:-  +86 20 3606 6999
Country:-  China
Continent:-  Asia
Formerly known are Bangalore is the capital of state of Karnataka. Knows as the city of garden with benevolent climate makes it a perfect holiday destination. Though there are no world-class sights, you'll find lovely parks and striking Victorian-era architecture. Cosmopolitan Bangalore is one of India most progressive and developed city. The center of India's high-tech industry, the city is also known for its parks and bustling nightlife. Being the third most populous city of India welcome to this Silicon Valley. Bangalore is no doubt the birthplace of Coffee Days. With at least one CCD at every corner of the street, you will never have to look for hangout places in Bangalore. From a long walk in Cubbon Park to hundreds of cafes, from trails of trees everywhere to the amazing weather, you can't help falling in love with the city.
Nice to know - The most number of government organizations and public sectors are located in Bengaluru.
Things to do
Best time to visit - enjoys moderate climate throughout the year and one can visitthis magnificent city at any time of the year. September and February see the highest tourist inflow.


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We are so excited to have so many wonderful organizations involved in the art|DBF. Below you'll find several resources to promote your organization's involvement with art|DBF.
The AJC Decatur Book Festival offers the Decatur Writers Studio: a learning and working resource for writers in the Atlanta area.
Click here to see a full list of past presenting authors at the AJC Decatur Book Festival.
The AJC Decatur Book Festival is the largest independent book festival in the country—but that's not all we do!
The organization behind the festival promotes a year-round literary community by hosting a series of fundraising and literary events.
Are you a fan of the DBF?
The DBF is your year-round guide to the best book events around Atlanta. Join us on Twitter and Facebook and keep up to date with all the great author appearances offered throughout our great city all year long.


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Latest By
"I think crypto will slowly percolate its way up and people will adopt it gradually as user friendly, cheap products, become available."
Compare to the "metallic Marx" from The Robots Strike (1959) by Harry Harrison.
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Datagrid Model Generation Perfect For Eternal Cities Of Science Fiction
'... there was enough flexibility to allow for wide variation.
Kazahk Ironist Protester Arrested For Blank Sign Protest
'...a man carried a white rectangular sign, blank on both sides.'
Bitcoin Surges Again, To $7,000
'... electronic, private cash, unbacked by any government, untraceable, completely anonymous.'
China Develops Taste Testing Robots
'Install taste buds in the end of one tentacle...'
North Sea Stone Age Reconstruction And Philip K Dick
'Your Dip digs back into antiquity. Rome. Greece. Dust and old volumes.'
Tesla Robotaxis Will Automatically Recharge Themselves
'Then it appeared to make up its mind, and trundled over to a wall socket...'
New Lifelike Material Powered By Artificial Metabolism
'... The biological robots were not living creatures.'
Husqvarna Automower 435X AWD
'Gramp Stevens sat in a lawn chair, watching the mower at work...'
Elon Musk Foretells Tesla Sans Steering Wheel
'How about the steering wheel... I don't need one.'
Adversarial Patches Trick Computer Vision
'The surveillance cameras can all see it, but then they forget theyve seen it.'
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WASHINGTON -- The Obama administration announced today it is extending the duration of non-immigrant visas for Cuban travelers from six months to five years, two weeks after officials from the two countries resumed long-stalled migration talks.
WASHINGTON -- The Obama administration announced today it is extending the duration of non-immigrant visas for Cuban travelers from six months to five years, two weeks after officials from the two countries resumed long-stalled migration talks.
The change also means Cubans approved for B-2 visas for family visits or personal travel will be allowed multiple entries, rather than be required to reapply in person each time they seek to travel to the United States. B-1 business and B-1/B-2 combination visas will still be for six months and a single entry.
"The increased visa validity removes procedural and financial burdens on Cuban travelers," State Department spokesman Patrick Ventrell said in an email to The Associated Press.
He added that it will decrease wait times for visa interviews at the U.S. Interests Section in Havana, which Washington maintains instead of an embassy because the historic Cold War foes do not have full diplomatic ties.
Ventrell did not say whether the policy switch was a direct result of the July 17 migration talks in Washington.
The discussions are supposed to take place every six months. However they had been on ice since January 2011, as the two countries butted heads on issues such as the imprisonment of a U.S. government subcontractor sentenced to 15 years in Cuba.
The resumption of the high-level talks, along with renewed discussions on reestablishing direct mail service, is among a number of signs of baby steps toward rapprochement in recent months.
In May, a U.S. judge gave a convicted Cuban intelligence agent the green light to return to the island even though his parole following a long prison term on spy charges had not yet ended. And in June, Cuba said it would allow an American doctor to examine Alan Gross, the jailed subcontractor.
Meanwhile, Cuba has reformed its own migratory rules, ending an exit visa requirement in January that had previously been imposed on all Cubans. Islanders can still be denied passports in some cases, such as for pending legal cases against them, but a number of the most outspoken dissidents have been allowed to travel overseas since the reform.
Ventrell said, however, that the change announced today does not amount to a significant change in Washington's policy toward Havana.
"The Obama administration believes these measures, in addition to others, will increase people-to-people contact; support civil society in Cuba; and enhance the free flow of information to, from, and among the Cuban people," he wrote.


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Krypton Casts Superman's Hot Grandpa
Oct 3, 2016 3:00 PM EDT
Move over Superman: you've just been out-hotted by your own grandfather. Or rather, ancestor, as SyFy and Warner Horizon Television have just revealed that actor Cameron Cuffe will take the lead role in their Superman-prequel pilot, Krypton. Set long… Read more


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ReleasesBack to
Jack Dejohnette
Jackie McLean's Jacknife sessions have had a peculiar and somewhat disjointed history in his discography. Initially issued in 1975 on a vinyl two-fer as part of the Blue Note reissue series, it included separate previously unreleased sessions from 1965 and 1966, the former with trumpeters Lee Morgan and Charles Tolliver, the latter in a quartet with only McLean as the leading horn. In CD form, the five tracks from 1965 were offered on a single CD. Pianist Larry Willis and a young drummer named Jack DeJohnette were on both recordings, with Larry Ridley (1965) or Don Pate (1966) filling the bass chair. As both sessions could not fit on a single CD, it's understandable but a shame that a double CD could not be produced including the fine quartet date. Nonetheless, the 1965 group has many worthwhile and often challenging moments for the then 33-year-old alto saxophonist. Of the five tracks here, "On the Nile" at over 12 and a half minutes should be a favorite, as its modern modal mainstream mystery wafts slowly over time like sands in an hourglass, a steady caravan trip with the deep piano chords of Willis, the evocative trumpet of Tolliver, and McLean richly harmonizing. Tolliver also wrote the title track, a sour-toned hard lemonade bopper on the cutting edge considering this mid-'60s time frame. McLean penned the tuneful, enjoyable "Blue Fable" on the steady swing side, briefly dishing out calypso beats. Morgan's feature is DeJohnette's "Climax" in a chopped-up piano riff with the drummer, as a bop line from the horns takes up the urgent, kinetic charge. The only track with both trumpeters, "Soft Blue" is easy as the title suggests, harmonic and warm, with solid solos showing the stark contrast between the approach of the two brassmen and the ruminating piano of Willis. These recordings do not tell the complete story of this time period -- please explore the Willis composition "High Frequency" and McLean's incredible "Combined Effort" from 1966 for examples of the quartet really cutting loose sans the trumpeters. The Complete Blue Note 1964-1966 Sessions four-CD limited-edition box set on the Mosaic label houses both Jacknife recordings. The single CD is quite worthwhile by itself, but tells only half of the story. ~ Michael G. Nastos


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Firebug 2.0 beta 3Friday, April 25th, 2014
getfirebug.com has Firebug 2.0 beta 3
Firebug 2.0b3 fixes 15 issues
Firebug 2.0b3 is compatible with Firefox 30-31
Highlights from this release
Apart from regular bug fixes and patches one new feature made it into this release. It's now possible to search in the HTML panel using regular expressions (issue 6713)
All you need to do is to check Use Regular Expression option in the search panel options dialog and type a regular expression in the search box.
Code Auto-completion
One of the things improved in Firebug 2 is related to code auto-completion. This feature has been improved on several places in Firebug. First, let's see the Command Editor in the Console panel (issue 55)
You can open the auto-completion popup window by pressing the <tab> key. The screenshot shows a case where the key is pressed after typing:
Another place where auto-completion has been improved is breakpoint condition dialog. It now offers variables in scope. Check out the following screenshot.
You can read about other auto-completion features in previous blog post.
Please post feedback in the newsgroup, thanks.
Jan 'Honza' Odvarko


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Ouch! Woman Finds Pearl In Her Pizza
Of all the things you might expect to happen while eating pizza, finding a pearl definitely isn't one of them. But that's exactly what happened to a South Carolina woman while enjoying a snack last Friday.
Pamela Levi was noshing on an oysters Rockefeller pizza at Goatfeathers restaurant when she bit down on something hard. At first, Levi thought she'd shattered one of her teeth. "I thought, 'I'm suing!'" she laughed. "I thought I had broken a tooth!"
But then, she fished the offending object out of her mouth and realized it was fully-formed pearl. It was a rare fine to be sure, with odds somewhere in the tens of thousands to one.
Unfortunately, however, Levi probably won't be able to cash in on her find. Restaurant oysters generally don't produce high-quality gems. Still, Levi has a heckuva story to tell. And she'll probably be checking her pizza slices for treasure from now on.


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The health IT field is rapidly growing. The march of the microprocessor into the health space may have been slow compared to other areas like finance or engineering, but that's changing, as more and more large IT companies like Microsoft and Google focus their attention on the sector. Intel, chip supplier supreme, has just received market approval from the FDA for its new Health Guide, a device that's designed to be a two-way portal between the user at home and their healthcare provider.
It looks forward to a future of ever-rising healthcare needs from an aging and obese population. Remote monitoring of chronic patients is actually a pretty good idea. Even if it's only utilized by the more technologically proficient subset of patients, these days that's a not-insignificant number. Their adoption of home monitoring would free up the need for more frequent home visits, thereby decreasing healthcare costs.
From the PR photos, the device has more than a hint of Apple about it, but it's married to a helping of hospital. A friendly-looking single box design with a fold-down touchscreen, it contains a 40GB HD and an unspecified processor/motherboard. The Health Guide has a built-in camera (again, very "Apple meets the intensive care unit"-looking), so patients can show their healthcare provider exactly where it hurts, or be observed to make sure they're treating themselves correctly. It also has USB and Bluetooth connectivity to interface with approved healthcare peripherals, which run the gamut from digital scales and thermometers to devices to measure lung function or basic blood work. The data that is gathered is then sent securely to the healthcare professional over the internet.
"Aha!" you say. Those sorts of things sound like they could be performed by any old household computer, but when you consider the target market—the elderly and the infirm—something easy to operate and with good accessibility makes sense. With the US already spending more than twice as much per patient per year on healthcare costs as other developed nations, anything that can help reduce healthcare overheads is going to be a winner.
Telemedicine has been used in the past to provide care to those who are in hard-to-reach places, and I can think of a few instances when telemedicine has also been used to make more efficient use of meager resources, like state healthcare systems where a small number of doctors have to cover a large geographical area. Assuming the days of higher fuel prices are here to stay, remote monitoring of home-care patients makes even more sense.


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- Home
- Mosaic9
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O3FA coated polypropylene mesh
Omega 3 fatty acid (O3FA) coated polypropylene mesh designed for open and laparoscopic hernia repair when a tissue separating layer is needed.
- Built on ProLite monofilament polypropylene mesh
- 25% less coating than previous generation of C-QUR Mesh
- O3FA coating results in minimal tissue attachment to the mesh
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How to order
To place an order or learn more about any of the Maquet products, related accessories, or therapeutic solutions, please contact your local sales representative.
- Contact us @wrappertag>


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79th Texas Legislature, Regular Session, House Bill 495, Chapter 1198
Description: Bill introduced by the Texas House of Representatives relating to the student enrollment required for the operation of Texas A&M University--Central Texas as an independent general academic teaching institution.
Date: June 18, 2005
Creator: Texas. Legislature. House of Representatives.
Partner: UNT Libraries Government Documents Department


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Physical Sciences
Research Highlights
June 2010
Small Particles, Big Impact
Distinguished professor discusses nanoparticles and the environment at PNNL seminar
Unstable nanoparticles can have important consequences on the larger environment, according to Dr. Alexandra Navrotsky, director of nanomaterials research at the University of California, Davis. An energetic scientist and an engaging speaker, Navrotsky leads research into the relative stabilities of common geological materials as a function of particle size, all the way down to nanometer scales. She shared her team's recent results at the Frontiers in Biogeochemistry Seminar Series at Pacific Northwest National Laboratory. The series features academic, government, and industrial leaders who discuss novel ideas and research advances.
In this seminar, the University of California professor discussed nanoparticles and their influences. Specifically, she discussed examples of her recent work in the relative energetics of nanophases and how at small scales, phases that are normally less stable can become dominant. She uses a technique called drop solution calorimetry to measure tiny amounts of heat released when materials are dissolved. The amount of heat is related in part to the atomic structure of the material. "Energetics whisper secrets of the strength of chemical bonds," said Navrotsky.
Water matters. Nanoparticles generally come wrapped in layers of water. The effect of that water must be considered when studying the relative energetics of nanoparticles. If water is ignored, "urban myths" ensue, as was the case with early work on titanium dioxide, which suggested that the atoms in the nanoparticle vibrate more easily than those in more massive material. Navrotsky and her team have disproved this myth, showing that this apparent effect was the result of the large impact of water on the heat capacity, rather than of changes in the lattice vibrations.
Shape matters. Nanoparticles are rarely perfect spheres. They come in configurations ranging from tiny, lumpy snowballs to large, spikey thorns to long rods or wires. The shapes and the water they effect influences how much energy is available inside the particles. By controlling the shape, scientists can create particles with different surface energies, capable of different reactivity and function.
These are just a few examples from the seminar, which attracted an audience of scientists from across Pacific Northwest National Laboratory.
Dr. Alexandra Navrotsky: A noted scientist and professor, Dr. Navrotsky is the director of the Nanomaterials in the Environment, Agriculture and Technology Organized Research Unit and the Peter A. Rock Thermochemistry Laboratory at the University of California, Davis. Her research interests have centered on relating the features of nanomaterials to the behavior of larger materials. Her extensive honors include National Academy of Sciences member, the Roebling Medal of the Mineralogical Society of America, American Geophysical Union Fellow, Geochemical Society Fellow, and the Benjamin Franklin Medal in Earth Science.


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Mennonite transportation
It's still interesting, even after 15 years here, to live in a neighborhood with a large number of Mennonite families.
In fact, our two nearest neighbors are Mennonite families. One family shares our lane -- they live about 1/4 mile from us. Our other Mennonite neighbors bought the farmland that originally went with our house. They live nearer to us, but we don't share a road so we don't see them quite as often.
The Mennonites around Hopkinsville often hire a car if they are going to town, and it has become a small industry around here to "haul Mennonites", as people say. It seems to be a good part-time job for retired people. Dennis has been doing some driving for our two neighbors. This brings in about enough money to keep gas in the cars.
I saw the horse and buggy in the photo above at a little Mennonite store near Fairview, KY -- the Pennysaver Market. Here's a bit of wisdom that is posted near their cash register: "The best way to double your money is to fold it in half and put it in your wallet."
This buggy is not too spiffy. It looks like it has seen some hard use. Our Mennonite neighbor boy who is Keely's age (21) has a really good-looking new buggy with a fancy polished wooden console inside it.
This young man has been dating a girl from the local Mennonite church for several years. Not long ago, his dad mentioned buying a little piece of land nearby and said that a house would be built there soon. We didn't ask any questions, but we are guessing that there will be a wedding after the house is built.
One final thing about buggies -- I believe that the Mennonites would call the vehicle in the photo a "carriage", not a buggy, but we English (non-Mennonite) people carelessly call them all "buggies".
Related posts:
Seen at Lowes
View Across the Field
One year ago today, I posted an old-time story about crossing the creek that our neighbor lady told me.


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Sorting through the juvenile fiction
We have come to the point in our house where we need another bookcase -- or fewer books. Unless I happen to find a cheap, good-quality, used bookcase, I always feel morally obligated to build one. So I decided to spare myself that task (and the challenge of finding a place in the house for another bookcase, once built.)
I sorted through most of our juvenile fiction, discarding duplicate titles, lesser works, extremely worn books, etc., and now I have a large, very heavy box of kid books sitting on the kitchen floor, waiting to go to the Salvation Army thrift shop.
But before I take it, I will let both Keely and Isaac see if they want to keep anything from it. These are books that accumulated during their childhood years.
I also made a list of the books I decided to keep. I have quite a habit of looking through any used books I find. If I have a list with me on my tablet as I'm looking, at least maybe I won't buy a duplicate book.
Here are the keepers. Note: this is not a list of all the great books I think kids should read. It's just a list of what's on my bookshelves tonight. I notice a sad deficiency in Mary Poppins and Little House books. Keely says that's because she and Isaac wore them out so thoroughly when they were kids. Also, no Little Women!
Well, I can't own them all. Not without more bookcases...
- Allen, Philip Schuyler: King Arthur and His Knights, A Noble and Joyous History
- Bowman, James Cloyd: Pecos Bill
- Cameron, Eleanor: Stowaway to the Mushroom Planet
- Cleary, Beverly: Beezus and Ramona
- Colder, Soon: Artemis Fowl
- Dahl, Ronald: Charlie and the Chocolate Factory
- Dahl, Ronald: James and the Giant Peach
- Dodge, Mary Mapes: Hans Brinker and the Silver Skates
- Estes, Eleanor: The Middle Moffat
- Estes, Eleanor: The Moffats
- Forbes, Esther: Johnny Tremain
- Graham, Kenneth: The Wind in the Willows
- Hale, Shannon: The Princess Academy
- Krumgold, Joseph: Onion John
- L'Engle, Madeleine: A Swiftly Tilting Planet
- L'Engle, Madeleine: A Wind in the Door
- L'Engle, Madeleine: A Wrinkle in Time
- Lawson, Robert: Rabbit Hill
- Lear, Edward: Nonsense Book
- Lofting, Hugh: Doctor Doolittle
- Lovelace, Maud: Betsy and Tacy
- Lovelace, Maud: Betsy and Tacy Go Over the Big Hill
- Maclachlan, Patricia: Sarah, Plain and Tall
- McCloskey, Roberta: Henry Reed, Inc.
- McCormick, Dell J.: Paul Bunyan Swings His Ax
- Neville, Emily: It's Like This, Cat
- Norton, Mary: The Borrowers
- Norton, Mary: The Borrowers Afloat
- Norton, Mary: The Borrowers Aloft
- O'Brien, Robert C.: Mrs. Frisby and the Rats of Nimh
- O'Dell, Scott: Island of the Blue Dolphins
- Paterson, Katherine: Bridge to Terabithia
- Rawlings, Marjorie Kinnan: The Yearling
- Rawls, Wilson: Where the Red Fern Grows
- Sachar, Louis: Holes
- Sachar, Louis: Wayside School is Falling Down
- Sachar, Louis: Sideways Stories from Wayside School
- Sachar, Louis: Wayside School Gets a Little Stranger
- Scott, Dr. Jonathan (translator): The Arabian Nights Entertainments
- Sewell, Anna: Black Beauty
- Shelley, Mary: Frankenstein
- Spyri, Johanna: Heidi
- Stevenson, Robert Louis: Treasure Island
- Twain, Mark: The Adventures of Huckleberry Finn
- Twain, Mark: Tom Sawyer
- Verne, Jules: Around the World In Eighty Days
- Verne, Jules: 20,000 Leagues Under the Sea
- Wells, H. G.: The Island of Dr. Moreau
- Wells,H. G.: The Time Machine
- White, E. B.: Stuart Little
- White, E. B.: The Trumpet of the Swans
- Wyss, Johann Rudolf: The Swiss Family Robinson
I have been typing this on the Nexus tablet that the family gave me for Christmas. Now I am going to attempt to take a photo with this little machine and add it to this post. After the post reaches the internet, I guess I will have to edit it with my desktop computer, so I can italicize the titles. I'm not seeing how to do that with the Blogger app I'm using. (And that's what I did.)
Edited 1/6, 10:55 p.m.
Retrieved by Isaac from the give-away box:
- Winthrop, Elizabeth: The Castle In the Attic
- Finger, Charles J.: Tales From Silver Lands
- Juster, Norton: The Phantom Tollbooth
- Selden, George: The Cricket in Times Square


text: Champions Together builds inclusive school communities by engaging students with and without disabilities in unified sports.Download Program Fact SheetIt's at the local level--right here--where interested volunteers meet the athletes. That's where the perceptions start to change and where the miracle of transformation takes place. Special Olympics Virginia provides year-round sports training and athletic competition in a variety of Olympic-type sports for children and adults with intellectual disabilities. Those activities give them continuing opportunities to develop physical fitness, demonstrate courage, experience joy and participate in a sharing of gifts, skills and friendship.


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The sixth edition of Gulf Film Festival, which kicks off on April 11, made Saudi Arabian drama Wadjda the opening gala feature as the perfect "homecoming" for the celebrated film.
"The wheel of that bicycle has moved perfectly. Wadjda is really the story of a Gulf film which broke all records and shows us what a Gulf film can do outside the GCC," said Abdulhamid Juma, the GFF festival Chairman in an interview on Tuesday. He added that this film, shot entirely in Saudi Arabia by the country's first female filmmaker, Haifaa Al Mansour, was symbolic of what his festival stood for and the potential that it held.
"In 2007, the script was with us and in 2009 it got a grant from Dubai Film Connection. Then there was this boom. It won top prizes at the Venice Film Festival and it's now playing in 12 countries. It was the third most watched film in France. It's exciting and comforting to see its achievements. Wadjda is coming home now," said Juma.
While the opening gala night is an invites-only event, the public can watch the film on April 16 at 9pm at Grand Cinemas in Dubai Festival City. Apart from winning three awards at Venice Film Festival, the feature won the Muhr Arab Feature and Best Actress Award at the Dubai International Film Festival in December 2012.
In the week-long festival, 169 films from 45 countries, subtitled in English and Arabic, will be showcased for the public for free. Out of the total number of films, 93 projects are helmed by filmmakers from the Gulf.
"This festival gives you an opportunity to see films that you were never going to see. These are films that will not be shown in theatres. There's 119 nationalities living in Dubai. My tip? Go see what the locals think. Don't make up your mind about them, thinking they drive in tinted cars or drive fast or wear something funny. You live here and you need to know how they think. Get inside their heads. You will be surprised because you may know something you never knew about them or you will find out that they are not very different from you," said Juma, when asked about why residents should participate in GFF.
The spotlight will not be solely on Wadjda, a tale of a girl coveting a forbidden green bicycle. GFF will also honour Kuwaiti playwright, actor and screenwriter Mohammad Jaber.
An array of short films, animated features and films for children will roll out during the GFF week. While Dutch filmmaker Sandra Welte brings Lift Off, a tale of a clumsy bird named Joey, France's Jeremy Clapin brings his quirky Palmipedarium, a tale about Simon who goes duck hunting with his father. Dubbed as an ideal platform for regional filmmakers to display their talents, more than Dh500,000 in funds are also up for grabs during the festival.
By Manjusha Radhakrishnan
Via SyndiGate.info
© Al Nisr Publishing LLC 2019. All rights reserved.


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The CT520-64 wireless traffic generator is an excellent choice for testing Access Points and other WiFi networks. The CT520-64 uses a modified Wireless driver for WiFi NICs based on the Atheros chipset. It can support up to 64 Virtual Stations. Each of the Virtual Stations has its own IP address, IP port space, MAC address and routing table. The Virtual Stations can be assigned to communicate to a particular Access Point, use a particular SSID, and have optional WPA2 key assigned. More advanced 802.1X authentication is also included. There is a single WiFi radio per CT520-64 but multiple LANforge systems can be clustered together for more realistic radio interference patterns and increased traffic generation capability. The radio supports 802.11 a, b, g or n mode. Transmit power and channel/frequency is configured on a per-radio basis. Most other settings are configurable per virtual station.
All virtual stations must be on the same frequency, but as long as the protocol supports that frequency, the multiple protocols can be used concurrently. For instance, if the radio is configured for a 2.4Ghz channel, the stations can be b, g, or n. If the radio is on a 5Ghz channel, the stations can be a or n. The bandwidth can be configured for all protocols. For 802.11n and 802.11AC, configuring the MCS rates also determines the number of spatial streams (1x1, 2x2, 3x3, 4x4 etc).
The Virtual Stations may be configured with all of the virtual interfaces on the same subnet, or different subnets, depending on the testing requirements. When used with something like VoIP, it allows all of the VoIP calls to use the standard IP ports (with one call per virtual interface).
The CT520-64 has no moving parts (other than the three removable external antenna on swivel mounts)
and will fit into a small travel bag or briefcase for easy portability.
It is also completely silent, so you can include it in your customer demos and presentations.
No additional hardware or software is required, but it is suggested
that you manage the system using the LANforge-GUI on a separate
machine. The CT520-64 can also be managed over a serial console
in text mode or through a directly connected monitor, mouse and keyboard.
|NOTE: This product may have a different hardware
configuration than the system pictured above.
Refer to your official quote for details.
|NOTE: This product may have a different hardware
configuration than the system pictured above.
Refer to your official quote for details.
List Price: $8,995 List Price with 1 Year support (17%): $10,524
Unless otherwise noted in the product description, these features usually cost extra:


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Irish funny man Chris O'Dowd upset his new wife, Dawn Porter, by taking a photograph of the TV star in her wedding lingerie and sharing the picture with fans.
The "Bridesmaids" star, who married TV host-journalist Porter in August, gave his thousands of Twitter.com followers a glimpse into his honeymoon by posting a snap of the brunette beauty in her underwear.
O'Dowd has now revealed his partner was "shocked" when she found out what he had done, but insists he only published the intimate picture because he was so proud of his sexy bride.
He tells Britain's Marie Claire magazine, "It wasn't a very 'me' thing to do, and she was a bit shocked, but I thought she looked amazing and I was so proud.
"You don't realize how many people will pick up on it; sometimes I treat Twitter like it's a bunch of people I know."
O'Dowd captioned the saucy shot, "There are times for restraint and there are times to boast about your sexy new wife! Look what I got!" while Porter tweeted, "That wasn't the wedding photo I was planning to release."


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Cops: Teens argue; one injured by dumbbell
Patricia Reyes, 19, of Carthage Street, struck a 15-year-old teen in the head with a dumbbell during an argument at the Carthage Street residence Monday afternoon, police said.
Police were alerted by staff at the emergency room at Bridgeport Hospital around 4 p.m., where the 15-year-old boy had top have stitches to treat a one-inch cut on his forehead.
Reyes told police said she and the teen were arguing and claimed he shoved her in the face, while he said she hit him in the head with a dumbbell.
She was charged with second-degree assault, risk of injury to a minor and disorderly conduct, while the 15-year-old was issued a juvenile summons for disorderly conduct.
Reyes was released on a $5,000 and was scheduled to have appeared Tuesday in Bridgeport Superior Court. The juvenile was released to his mother's custody and was scheduled to appear Tuesday in juvenile court.


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NEW HAVEN — Seated around circular cafeteria tables in the frigid basement of Beeman Elementary School, the New Haven Planning Commission on Monday evening debated changing the town plan to assert more local control over how energy projects, particularly solar arrays, are sited within the town.
MIDDLEBURY — In addition to making their decision on using option tax reserves for a utility project, members at their Tuesday meeting also approved several moves that came before the board earlier this summer.
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MIDDLEBURY — Middlebury residents on Tuesday offered their input on a number of proposed town plan and zoning bylaw revisions, some of which would pave the way for the construction of the new municipal building at 77 Main St.
Are you one of the 915 Middlebury residents who voted "yes" on the March town meeting bond vote for the municipal building project?
Would it have influenced your vote at the time if the selectboard (instead of repeatedly assuring voters that the proposed project was compatible with the vision and spirit of the town plan) had revealed instead that altering the town plan to accommodate the project would be part of the process?
MIDDLEBURY — The Middlebury selectboard on Tuesday formally adopted the community's updated town plan, a weighty document that local officials and residents expanded, tweaked and sometimes heatedly debated over the course of more than two years.
The board voted 6-0 in favor of the document, with Selectman Travis Forbes unable to be present. The town plan describes the community's assets and its growth priorities for the next five years.
MIDDLEBURY — The Middlebury selectboard on Tuesday made its revisions to the draft town plan and warned it for a Tuesday, Nov. 13, public hearing during the board's regularly scheduled meeting. That meeting begins at 7 p.m.
At issue with the five-year update of Middlebury's town plan is a crucial question: should the town keep a cap limiting retail stores to 50,000 square feet.
The measure has been part of the town plan for several years now, and was initially adopted to prevent the location of a Wal-Mart, or any other big-box store, to locate on the town's outskirts or become the anchor of another strip-type mall on the town's periphery. If past surveys are an accurate reflection of the public mood, most residents do not want the town to become a haven for big box stores.
MIDDLEBURY — The Middlebury selectboard on Sept. 18 will hold its first of two public hearings on a proposed updated town plan that now bears many of the suggested changes offered by citizens at two planning commission hearings held this past spring.
BRISTOL — After making three small changes to Bristol's proposed town plan on Monday, the selectboard OK'd the document. The plan will be presented to the public at two public hearings on Aug. 27 and Sept. 10.
The selectboard's approval of the proposed plan comes after the Bristol Planning Commission supported the previous 42 changes the selectboard made to the document over a revision period that spanned several months. The planning commission issued its approval of the board's changes on July 17.
BRISTOL — After almost a decade of helping shape a proposed town plan, the Bristol Planning Commission may have considered the document for the last time on Tuesday.
At its monthly meeting, the planning commission unanimously OK'd the 42 revisions proposed by the selectboard.
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The holiday season still sparkles at Newport's Ritz Restaurant. Stopped in for lunch Tuesday to celebrate our 36th wedding anniversary and found that the Christmas lights were still ablaze as Ritz restaurateur Ray Jacobi greeted the arriving crush, wishing his patrons a happy and healthy New Year.
As we settled in to our black, tufted-leather booth, surrounded by all the tradition we have come to know as familiar in a world where the old standards have vanished, I thought for a moment about the legacy of Ritz founder Hans Prager. It is interesting how one life can impact so many people, even in a relatively small community. Prager, a child of war-torn Europe in the early part of the 20th century whose family somehow made it to China, escaping persecution and certain death in Germany, would eventually create an amazing reputation in Southern California as one of the preeminent restaurateurs, first in Los Angeles and then in Newport Beach.
In the early days, Prager's clients and friends formed an association known as the Noble Vikings, which originated in pre-Ritz days when Prager worked in Los Angeles at the legendary Scandia Restaurant on Sunset Boulevard. This group would band together over decades for both social and business connections with the underlying purpose of giving back to the community, which has afforded them the opportunity to prosper and flourish in their own lives.
Today, some years after Prager's passing, the Noble Vikings continue in the spirit of giving back and over the holidays produced their annual Christmas gift- and food-box drive, supplying nearly 1,500 50-pound boxes created by Viking volunteers. The boxes were then distributed by 14 participating charities in Orange County assisting needy people. It is estimated that each food box supplied holiday nourishment for approximately eight people, which means that nearly 12,000 people enjoyed Christmas dinner, thanks to the Noble Vikings.
Major donors to the cause include Simple Green, Sunshine Makers Inc., the Hausman Family Foundation, Mike Knapp, Stacy and Aleks Renshaw, the Bartlett Foundation and Bill Piercey. Financial support from these folks brought in close to $50,000, making the 2012 event a win-win for the community. Among the charitable recipients were Civic Center Barrio Housing, Homefront America, Pio Pico Elementary School in Santa Ana, and Boys and Girls Clubs of Santa Ana, Tustin and the Harbor Area. Also supported by the Noble Vikings were Orangewood Children's Foundation, St. Michael's Society and Latino Health Access, to name only a few.
The Ritz Restaurant will join a long list of participating restaurants as Newport's official Restaurant Week kicks off Jan. 18 and runs through Jan. 27. The seventh annual citywide culinary celebration will offer special three-course prix fixe menus at prices of $10, $15 or $20 for lunch and $20, $30 or $40 for dinner. For a list of the 70 participating dining rooms and more information regarding the 10-day event, visit http://www.newportbeachdining.com.
Celebrating the New Year in grand traditional style was the Balboa Bay Club & Resort, where I am editor of the Bay Window, the club's official publication. General Manager Dieter Hissin welcomed a crowd of some 300 revelers for a New Year's Eve celebration in the ballroom festooned in shimmering gold, silver and white décor. The evening was produced by Malcolm Smith, director of club operations, working with hotelier Richard Szilagyi and special event coordinator Aaron Trent. The crowd was in awe over the digital special effects, which produced spectacular images on the ballroom walls throughout the evening. Creative floral designs by Karri Selvaggi featured verdant white roses mixed with both silver steams and golden succulents centering tables topped with shimmering gold sequined overlays.
As much of the West Coast was celebrating the New York New Year at 9 p.m., the formal dinner dance was just getting started on the bay. Champagne flowed in the foyer as the ballroom doors were opened to reveal a massive, high-polished white dance floor fronted by the band Rembrandt. More than 1,000 gold, silver and white balloons were suspended high above the floor as the New Year's Eve crowd, including Kyle and Danielle Shotwell, George Morris and Jann Williams, Diane and Doug Overbee, Shawn and Jay Rowerdink, Howard Lieberman, Traute Huycke, Rex O'Day, Courtney Neils and Leah and Casey Hannegan danced the night away. Also spotted in the crowd enjoying Executive Chef Josef Lageder's holiday dinner, featuring saffron lobster risotto, seared diver sea scallops and roasted Colorado veal rib-eye, were Malcolm and Maria Elan, Josephine and Victoria DiGiorgio, Kara and Marty Everin, Ron and Gail Soderling and Anthony and Ginger Jordan.
THE CROWD runs Fridays. B.W. Cook is editor of the Bay Window, the official publication of the Balboa Bay Club in Newport Beach.


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Viz wrote:
With that said, I still think this is all unlikely, but hey, stranger things have happened. If the Lakers can get Gasol and the Clippers can get Camby why can't we get Josh Smith?
yea i would look at it that way... i mean all the impossible seemed possible this offseason haha, plus the lakers addition of gasol. If the clips can get camby for a 2nd rnd pick and lakers getting gasol for kwame and 1st rounders why cant we get a player like smith for say a shitty return for the hawks
haha its not even a second round pick... its the option to swiitch second round picks. they still have to possibly send one back or just keep it the way it is.


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UK's Most Borrowed Authors -The Top Ten
More from the BBC and the Public Lending Right. This time it's a list of authors most borrowed from UK libraries. Again the stats cover June 2007-June 2008. Most Borrowed Authors in the UK James Patterson Dame Jacqueline Wilson Daisy Meadows Nora Roberts Francesca Simon Mick Inkpen Josephine Cox Danielle Steel Janet & Allan Ahlberg […]Read more


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Welcome to MY Consulting Group
Most companies will tell you they value long-term client relationships. We actually believe that. Our goal is to be the consultant of choice in the markets we serve, and every part of our philosophy is derived from our complete commitment to our clients.
First, we value our integrity above all else. Our company was founded on the belief that the only way to maintain our credibility is to be in a position to give our word without reservation. Ask for names of clients who have worked with us for years. We want them to tell you how seriously we honor our reputation.
Second, we understand that you seek outside assistance to either access expertise not currently available within your organization or supplement in-house resources to best achieve your goals and timelines. We hold ourselves to the highest standards of providing value-added services and solutions to our clients. We aren't interested in being all things to you or wasting your time – we're interested in partnering with you to accomplish more for your organization.
Finally, we consider our employees to be clients as well. Why is this important? Because we hire and retain the very best. Companies plagued with turnover and poor morale are distracted and unable to give you their best effort. We hold our employees accountable to the client and we hold ourselves accountable to our employees.
Are you getting what you need from your current consulting team? MY Consulting Group wants to be YOUR next solutions partner.


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A 15-foot tall, pink, er, ah, well, what's been dubbed a pink penis has sprouted from the edge of the cliff in the Montauk moorlands. Neighbors say they feel violated, aesthetically speaking.
The few oceanfront homeowners in one of Montauk's most exclusive neighborhoods say the work of art has ruined the dramatic panorama that stretches down the hoodoo-sculpted bluffs out onto the Atlantic Ocean to the horizon. To make matters worse, the pink piece is illuminated at night.
The art is a work by the Austrian sculptor Franz West, who died on July 25 in Vienna. He was 65.
The neighbors have politely suggested to Adam Lindenmann, an art collector and critic for The New York Observer, that if he must erect the thing he could kindly move it back from the cliff to a less exposed location. There has been no response, they say.
Mr. Lindenmann caused a stir several years ago when he installed "Bear/Lamp," a sculpture by Urs Fischer of a giant yellow teddy bear leaning against a reading lamp, on his Montauk moorland property. It was installed closer to Mr. Lindemann's house, but the yellow bear raised Montauk eyebrows nonetheless. It continues to serve as a range marker for surfers and fishermen.
Art is one thing, but the East Hampton Town Code would likely describe Mr. Lindemann's new sculpture as a structure and as such, it would likely require a variance in order to be placed in its present location. The thing could also be in violation of the town's lighting regulations.


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UW Starts Fall Semester on Aug. 26th
LARAMIE, Wyo. (AP) — The University of Wyoming will welcome back students this week before fall semester classes start next week.
UW residence halls open to students on Thursday. Freshmen students living in the residence halls and their parents are invited to the Washakie Center's Welcome to Wyoming dinner Thursday from 3:30-6 p.m.
UW President Bob Sternberg will welcome freshmen on Thursday night in the College of Arts and Sciences auditorium as part of the Summit Transitions Program. Sternberg also will host a free welcome barbecue next Monday evening in Fraternity Mall.
Students can listen to motivational speaker Anthony Robles, a one-legged NCAA wrestling champion for Arizona State, on Friday afternoon.
UW football coach Dave Christensen and basketball coach Larry Shyatt also be on hand to welcome students.


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Refreshing our look, our services, and our salon is a great way to get ready for the busy coming season. It is a great reminder, Jill, that we need to periodically look at our ourselves and
Read more
It's spring and everything around us is changing and in bloom. For a lot of us the snow is starting to melt and we can actually see the grass again. The grass is starting to turn
We as a salon started going through the book "Over the Top" by Michael Cole this January. We had our monthly staff meeting yesterday morning and we are doing one chapter a month as a full
I am so excited to see all of the comments. Thank you AthenA, Annette, Heather, and Judy! We love seeing your comments and hope that more people will post. As I started responding to the comments,
I agree Jill, writing for NAILS has been an amazing experience. It has been an honor and a dream come true to be a part of the Coaching Chronicles. Thank you NAILS Magazine for the opportunity and
Wow! Thank you for your kind words and comments Sandy, Samaima, and AthenA. My faith, my friends, and family have all helped me through these tough times. 2012 was a tough year. I am, however, excited
It has been quite a year for you, Jill. I know it must have been difficult to write honestly about how your highs and lows for last year. I am humbled and reminded how easily we can
Happy New Year! Are you so glad to be done with 2012? I am! I have never had a worse year than 2012. So, since it's a new year, I want to remind you of what
I hope that all of our readers had a wonderful holiday both personally and professionally, and that you were all as busy as you could be. My wish for all of you is that you all
Our "Practice Now, Shine Later" series continues with another business building idea: host a holiday open house. It's not too late. Really you can pull it together in a week. One of my employees Kimberly suggested
This week I am going to respond to both of Jill's last posts. First I will talk about how a referral program during the holiday season has helped us to stay busy during January and February.
We're about halfway through our "Practice Now, Shine Later" series. So far, I have given you two techniques to help you make your clients sparkle and shine this holiday season. We introduced "Foil Nails" and "Glitter Toes." Those
Last week I mentioned that I was off to help with the makeup for our benefit fashion show. I have to say it was a great experience. Myself and about five of the other employees at the
This is my friend Nicole before her wedding. This is her "something blue." We used royal blue, silver, and turquoise glitter. We're continuing our "Practice Now, Shine Later" series. Last week, I introduced you to Foil Nails for
That is a cool look, Jill. This look can be done in a variety of ways. It can be done with Gelish by following the steps below. 1. Sanitize your hands and the guest's. 2. Push back
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(Reuters) - Herbalife Ltd
The company's China sales rose more than 120 percent in the fourth quarter of 2013, the fastest of any region worldwide, prompting the firm to estimate adjusted profit of $1.25 to $1.29 per share in the first quarter this year. It had earlier forecast $1.24 to $1.28 per share.
Direct sales models have recently come under fire in China. Authorities launched a probe into Herbalife rival NU Skin Enterprises Inc
"Direct sales groups are well organized and can have a lot in common with other social and political organizations, which is why China is rather wary of them," said Torsten Stocker, Hong Kong-based partner at consultancy firm A.T. Kearney.
Herbalife, which took around 10 percent of its global sales from China last year, has 200,000 sales representatives in the country using a "unique marketing program" to meet Chinese regulations, it said in its latest annual report.
Growth in China helped boost fourth-quarter net profit 10 percent to $123.5 million, while revenue rose 20 percent to $1.3 billion, in line with the company's estimate.
The U.S. firm has also had to fend off criticism about its sales model after activist investor Ackman accused it in December 2012 of running a "pyramid scheme" and took a $1 billion short position in the firm. Short-sellers make money when the stock price of a company drops.
The U.S. firm has always vehemently denied that it operates a pyramid scheme, which is an unsustainable business that typically makes most of its money by recruiting distributors rather than selling products to real customers.
Herbalife, which sells products through a network of independent distributors, reported an adjusted profit of $1.28 per share for the fourth quarter ended December 31, above an expected $1.25 per share according to Thomson Reuters I/B/E/S.
(Reporting by Aditi Shrivastava and Adam Jourdan in SHANGHAI; Editing by Don Sebastian and Matt Driskill)


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Mad game this. Like watching summat from the 70s.
Gueye isn't quite Kante level of awesomesauce, but he does a good impression.
I'm more trusting of fellas when they have my cock in their mouth
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Saint Leon has long been considered one of the best sprinters on the grounds at Arlington International Racecourse, but after Saturday's gutsy victory in the Listed $100,000 Arlington Sprint, the 8-year-old speed demon could be mentioned as one of the best in the country. Sprinting wire-to-wire in a race turned inside-out by a bad break, the son of Stravinsky dueled the length of the stretch with Hogy, eventually turning back the highly regarded graded stakes winner to win by a head under E. T. Baird.
Coming into the Arlington Sprint on one race in 52 weeks was not by design. Boyce had hoped to get a race into the gelding between his seasonal debut and Saturday, but the race didn't go. "I was able to get two works into him, and that seemed to do the trick," she reported.
Being so lightly raced over the last few seasons can be attributed to why he is running his best at age eight, according to the trainer. "We've taken very good care of him. And, a lengthy winter vacation really helps. He goes up to a farm near the Wisconsin border and just spends time being a horse," Boyce said.
Sunday morning, the speedy gelding looked like a happy horse in the Boyce barn on the Arlington backstretch. "He's just perfect, today. I couldn't be happier," the trainer stated. "He's just a remarkable horse."
As far as what's in the future for the Margaret Burlingham-owned local star, a freshening and a focus on the fall season are prominent. "I'll sit down with Marge and see what's available. There's something at Keeneland we will take a look at. He seems to run best fresh, so we'll space it out," Boyce said.
With the manner in which Saint Leon has won his last two races, that fall season could include the biggest race of all for turf sprinters – the Grade I $1,000,000 Breeders' Cup Turf Sprint. "It's certainly within the realm of consideration," the trainer mentioned candidly. "I think he could be competitive. The downhill turf (on Santa Anita Park's downhill turf course) is a bit of a concern. The local horses have a pretty big advantage."
The Breeders' Cup Turf Sprint is held at Santa Anita this year and is on an about 6½-furlong course (one furlong farther than the Arlington Sprint) that involves a slight right-hand turn in the first quarter-mile while on a downhill slope. "I'm not worried about the distance. He's won going a mile, so it wouldn't be a problem. He can place himself very well and if he gets any quarter where he can relax, he goes at least 7/8 (when sprinting)," Boyce stated.
The possibility of Arlington's top sprinter racing competitively against the best in the nation is not too far fetched of an idea considering his performance on Saturday. In a race that saw his final 3/16 clocked in a blistering :16.84 (.80 or approximately four lengths faster than last year), Saint Leon earned a 120 Equibase Speed Figure – the third-highest turf sprint figure of 2013. By comparison, in the other two similar turf stakes in the nation this weekend, the Grade III $200,000 Parx Dash Handicap at Parx Racing and the Listed $100,000 Bob Umphrey Turf Sprint at Calder Race Course (each with similar fields in terms of quality), produced winners with Equibase Speed Figures of 112 and 117.
Earning a 120 for his runner-up finish, Hogy exited the race very well, according to assistant trainer John Pool. "He bounced back and is feeling good. He was snapping (biting) this morning – so that's good. He has a little attitude – that's him. Everything looks good," Pool reported. "He just had a little bad luck at the start and then down the stretch. He ran a good race. The winner made him drift out and he lost his momentum a little. I think with a little more distance he would have worn him down and won."
Hogy, a 4-year-old gelding, will now be pointed toward the fall, but no race has been decided yet by owner William Stiritz and trainer Scott Becker. With a win in a graded stakes on the main course at a one-turn mile and a head-loss in a listed stakes in a turf sprint, he has the versatility to keep his options open. "You can't complain because he showed up two big races in a row. He has a bright future," Pool concluded.
Carl Moore's Chamberlain Bridge, who was moved up to third after Global Power was disqualified to last for his gate incident, came out of the race in good order, according to trainer Bret Calhoun on Sunday morning. "He came back good and I thought he ran well," stated the trainer. "I just think he was outrun at the end. There wasn't a lot of speed to begin with and we had to be forwardly placed, which isn't his usual style. He probably wants to sit back off and make a run."
A previous winner of both the Arlington Sprint and Breeders' Cup Turf Sprint (both in 2010), Chamberlain Bridge was sent off as one of the favorites. As far as his future, the trainer has no immediate plans. "I am not sure. He's got a little age on him. We might need to dodge the top couple," Calhoun said in regard to Saint Leon and Hogy.
Fourth-placed Cherokee Lord, who was finishing fastest of all at the wire, also exited the race well. "He ran a really nice race. He got in a little trouble, that's all," said trainer Charlie Livesay. "The jockey was really getting him going at the end and he made up about six or seven lengths. Had he not been knocked around at the beginning, I think he would have run even better."


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The Phobos-Grunt Mars Moon spacecraft has hit water! According to Russian defense ministry reports, the re-entering satellite fragmented and fell into the Pacific Ocean about 1,250 km west of Wellington Island, an island to the west of the Patagonian Ice Field, Chile. The crash took place at 18:45 CET, say several sources.
More details from our previous report: http://techie-buzz.com/science/phobos-grunt-crash.html
The craft…
There was initial panic and both Roskosmos and NASA played crucial roles in assuring the public that the fears were unfounded. The fears of a toxic nuclear fuel spill were allayed by statements by NASA on their website.
Initial reports indicate that no spill has taken place. There have also been no reports of any debris falling on habited areas.
… And the dreams surrounding it.
The spacecraft was supposed to land on Mars' moon, Phobos, in order to study the satellite. It was supposed to collect soil samples and return to Earth. Unfortunately for the $170 billion craft, it failed right during the launch and was stuck in orbit for a long time. It had even gone off the radar. After several unsuccessful attempts at locating and communicating with the craft, it was finally found. Several attempts were made by both Russian and American scientists to bring the craft safely back to Earth or to steer it to its original mission. All efforts failed. Left with no options and a potentially dangerous craft hanging mid-air, Roscosmos, the Russian Space Agency, along with NASA, decided to send the craft to a watery grave.


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I was thinking the other day what tiny little project could I made with my fall fabric scraps. I was also burning my favorite candle at the time, (yankee candle autumn leaves scent) and this is what I came up with!
1. Using pinking shears cut out 2 circles about 4" with a flat bottom for front and back of pumpkin.
2. Cut out 1 from quilt batting and trim around the quilt batting another 1/4" so that it is smaller than the fabric pumpkin pieces.
3. Sandwich the quilt batting between the 2 pumpkin pieces.
4. Make a stem in the same manner from green fabric.
5. Pin the stem to the top of the pumpkin. Stitch around the outside of the pumpkin and stem 1/4".
6. Using pinking shears cut out 3 straight moon shaped pieces from a different orange fabric. Pin in place and stitch down center through all layers.
7. Place little pieces of raffia, and hand-sew a button catching the raffia and all 3 layers of fabric.
Now, you can turn it into a magnet, lapel pin, Autumn ornament, or a fabric candle ring!
To turn it into a candle ring, measure around the candle jar and cut the elastic. If you are using a large Yankee Candle jar like I did, I cut my elastic 12.5". Overlap the elastic by 1". Pin. Stitch in place. Attach the elastic to the back of the pumpkin and stitch in place.
Have fun!


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News Room
We strive to provide Southern Kentuckians with information to keep them abreast of the many activities and endeavors of The Medical Center. Here you will find previous and current news releases as well as recent stories in the news featuring The Medical Center, its programs, employees and community activities.
For members of the media, please utilize this section of the website as a reference for information on The Medical Center. Also, please take the time to familiarize yourself with our policies concerning release of information and whom you should contact for media inquiries. Our marketing and public relations staff is here to assist you in any way possible.


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Deploying the Application on the Toolstick
Deploying the application on the Toolstick requires only providing the board-specific initialization and the time-tick interrupt, which must call the QP-nano function
QF_tick() to generate the
TIMEOUT events. The PELICAN example contains a small board support package (bsp.c) for the Toolstick, which has been modeled largely after the standard PWM_demo application that comes on the Toolstick CD.
The code accompanying this article contains an extensive README file explaining all the examples included and the usual workarounds for minor bugs in the demo tools and their incompatibilities. I just wanted to mention here that I ended up using the 4-KB KickStart(tm) 8051 compiler from IAR Systems, instead of the 2-KB demo version of the Keil 8051 compiler that comes with the Toolstick. Finally, because the memory footprint is of primary interest in this article, here are the numbers I've obtained with the IAR 8051 compiler optimized for size: QP-nano: 1254 bytes of CODE, 1 byte of DATA; application totals: 2712 bytes of CODE, 16 bytes of DATA, 88 bytes of IDATA (including 64 bytes of stack), 1 byte of BIT memory.
Reuse of Behavior in UML Statecharts
Statecharts achieve reuse of actions and transitions through a combination of hierarchy and "programming-by-difference" semantics. States may have substates that inherit the actions and transitions of their superstates, just as classes have subclasses that inherit the attributes and operations of their superclasses.
For example, a state diagram of a pocket calculator can be vastly simplified by introducing an abstract superstate "on" that contains most of the calculator states inside (see Figure 4).
To understand how the high-level transitions apply, assume that the user presses the
CANCEL button while the calculator state machine is in the
result state. The state
result does not pre-scribe how to handle the
CANCEL event. However, the
CANCEL event is not silently discarded, as it would be the case in the traditional FSM. Rather, because
result is now nested inside the
on superstate, the state machine attempts to handle the event at the higher level of state hierarchy of the
on state. Because UML statecharts support entry and exit actions on states, the self-transition
CANCEL in the
on state requires in this case exiting the
result state, exiting the
on state, en-tering the
on state again, taking the initial transition within the
on state, and finally entering the
begin state.
In summary, the transition
CANCEL took the state machine from state
result to state
begin, properly exiting and entering all the states on the way. Identical argumentation can be made for every substate of the
on superstate, so the single
CANCEL transition in the
on superstate replaces all low-level transitions that would be necessary in the traditional "flat" FSM without hierarchy.
As you can see, the semantics of hierarchical state nesting is based on the "programming-by-difference" principle. All substates of the
on superstate need only define the differences from the superstate, and otherwise can reuse the behavior by simply ignoring the commonly handled events, such as
CANCEL or
UML-style state machines can help you produce efficient, maintainable, testable systems with well understood behavior, rather than creating the usual "spaghetti" code littered with convoluted ifs and elses. In this article I've demonstrated that the technique is applicable to quite small systems, starting from about 4KB of ROM, and some 128 bytes of RAM.
Contrary to widespread misconceptions, you don't need big UML tools to take full advantage of the hierarchical state nesting and the guaranteed initialization and cleanup of states, which are the most important features of UML statecharts. In fact, manual coding of a nontrivial PELICAN crossing statechart turned out to be a rather simple exercise in following just a few straightforward rules. The implementation technique based on an "event processor", such as QP-nano, results in concise, highly maintainable code that truly reflects the statechart structure without any repetitions. The resulting state machine representation in C is flexible, allowing even sweeping changes in the state machine structure to be accomplished quite easily, at any stage of the project.
Once you design a system with UML statecharts, you will not want to go back to the "spaghetti" code or even to the traditional RTOS. Welcome to the 21st century.
IAR Embedded Workbench for 8051: KickStart Version.
Miro Samek is the Founder and President of Quantum Leaps, a provider of real-time, state machine-based application frameworks for embedded real-time systems, and author of "Practical Statecharts in C/C++" (CMP Books, 2002).


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"The key to a happier and more successful world is the growth of compassion."—His Holiness the Dalai Lama
Giving and receiving affection is the key to happiness, and compassion is the key that opens our hearts to affection. Illuminating themes touched upon in The Good Heart and
Collected here for the first time are four of the Dalai Lama's most accessible and inspiring teachings on compassion. The purpose of life is to be happy, His Holiness reminds us. To be happy, we should devote ourselves to developing our own peace of mind; the more we care for the happiness of others, the greater our own peace of mind. Therefore, we must develop compassion for others in order to be truly happy.
In these four teachings—imbued with the gentle humor and extraordinary kindness of this incomparable teacher—His Holiness explores altruism and the need for compassion on an individual as well as a global scale. He offers specific practices for developing loving-kindness and compassion in even the most difficult situations.


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Bontrager Foray Shorts
This item is currently not available.
Save the lycra for road rides and reach for the Foray Short when you hit the dirt for its minimalist, lightweight and durable design.
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• One zippered hand pocket
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• Semi-fitted - Follows the curves of your body with room for movement


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Brewed by Bear Republic Brewing Co.
American Wheat Beer4.2% ABV
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Heads up! Bear Republic American Wheat may not be available near you. Follow this beer to get notified when it's available nearby, try searching in a different area, or discover some similar beer.
Witbier4.8% ABV10 IBU
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Allagash Brewing CompanyPortland, ME
Brewed with a generous portion of wheat and spiced with coriander and Curacao orange peel, this beer is fruity, refreshing and slightly cloudy in appearance.


text:
Hi! I'm Lorenzo.
Benvenuto nel mio blog!
Qui descriverò le mie esperienze in Australia, darò consigli a chi vuole partire come me e parlerò di curiosità e argomenti interessanti. (:
Hi! I'm Lorenzo.
Welcome to my blog!
Here I will describe what I am up to, give advice for people who would like to leave for Australia and discuss about interesting topic. (:
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10 tips – how to learn English
Nowadays, English is becoming fundamental for our life. In the era of Internet people need a global language to communicate and the most widely used language is English, which has over 1.8 billion users world wide. The first thing you … Continue reading
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What is Cloning?
"The terms recombinant DNA technology, DNA cloning, molecular cloning, or gene cloning all refer to the same process: the transfer of a DNA fragment of interest from one organism to a self-replicating genetic element such as a bacterial plasmid (cloning vector). The DNA of interest can then be propagated in a foreign host cell. This technology has been around since the 1970s, and it has become a common practice in molecular biology labs today." (from the Cloning Fact Sheet more info.)
Cloning is frequently employed to amplify DNA fragments containing genes, an essential step in their subsequent analysis.
How Does Molecular Cloning Work?
Cloning of any DNA sequence involves the introduction of a foreign piece of DNA into an extrachromosomal element (cloning vector) of an organism which then produces copies of the vector as it replicates itself, thereby amplifying the DNA of interest. The whole process can be summarized in the following steps: fragmentation, ligation, transfection, screening/selection, and conformation of insert.
Cloning Vectors:
A cloning vector is simply a DNA molecule that can be inserted into a host cell and replicates inside the host (bacteria or yeast), producing many copies of itself and the insert DNA. All cloning vectors contain -
- A sequence that allows for the propagation of itself in the host.
- An insertion site for the foreign DNA - also called a multiple cloning site that can be cut by several restriction enzymes.
- A method for selection of the host cells that contain the insert DNA of interest. This is most often done through the use of selectable markers for drug resistance.
Types of Cloning Vectors:
- Plasmids - extrachromosomal circular DNA that autonomously replicates itself in a bacterial cell. Plasmids can be high or low copy numbers with an insert limit of about 10,000 base pairs (10 Kb)
- Phage - viruses that infect bacteria (usually derivatives of lambda bacteriophage). They are normally linear DNA molecules with regions that can be replaced without disrupting their ability to direct their replication by their bacterial hosts - insert limit of about 20 Kb
- Cosmids - circular extrachromosomal elements that combine elements of plasmids and phage - insert limit of 35-50 Kb.
- Bacterial Artificial Chromosomes (BAC's) based on mini-F plasmids - insert limits of 75-300 Kb.
- Yeast Artificial Chromosomes (YAC's) - artificial yeast chromosomes that contain telomeres, an origin of replication, a yeast centromere, and a selectable marker for identification in yeast cells - insert limits of 100-1000 kb.
Applications -
- amplifying 16s RNA genes to identify individual microbial species
- create cDNA libraries to determine what genes are being expressed at a particular time
- create genomic libraries in order to sequence organisms
- create multiple clone libraries in order to conduct metagenomic studies
How to Clone DNA Fragments -
- Fragmentation - Initially, the DNA of interest needs to be fragmented to provide a relevant DNA segment of suitable size. Preparation of DNA fragments for cloning is frequently achieved by means of PCR, but it may also be accomplished by restriction enzyme digestion and sometimes fractionation by gel electrophoresis.
- Ligation - Subsequently, a ligation procedure is employed whereby the amplified fragment is inserted into a vector. The vector (which is frequently circular) is linearised by means of restriction enzymes, and incubated with the fragment of interest under appropriate conditions with an enzyme called DNA ligase.
- Transfection - Following ligation the vector with the insert of interest is transfected into cells. Most commonly electroporation is employed, although a number of alternative techniques are available, such as chemical sensitization of cells.
- Screening and Selection - Finally, the transfected cells are cultured. As the aforementioned procedures are of particularly low efficiency, there is need to identify the cell colonies that have been successfully transfected with the vector construct containing the desired insertion sequence. Modern cloning vectors include selectable antibiotic resistance markers, which allow only cells in which the vector has been transfected, to grow. Additionally, the cloning vectors may contain color selection markers which provide blue/white screening on X-gal medium.
- Conformation - Nevertheless, these selection steps do not absolutely guarantee that the DNA insert is present in the cells obtained. Further investigation of the resulting colonies is required to confirm that cloning was successful. This may be accomplished by means of PCR, restriction fragment analysis and DNA sequencing.


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UNIVERSITY PARK, Pa. -- It is said that the good teacher informs, but the great teacher inspires. Eric Silver, professor of sociology and crime, law and justice, combines a talent for teaching with a passion to enrich students' experiences at Penn State, leading to his selection as the inaugural recipient of The Malvin and Lea Bank Outstanding Teaching Award for the College of the Liberal Arts.
The $5,000 annual award was established with a generous gift by Mal and Lea Bank, who are alumni and longtime benefactors of the College of the Liberal Arts and Penn State. Mal Bank is 1952 Penn State graduate with a degree in arts and letters, and an accomplished tax law attorney with Thompson Hine LLP, headquartered in Cleveland. He served as general counsel for the Cleveland Foundation, one of the nation's largest community foundations, from 1965 to 2003. He also has been a trustee for more than 30 charitable and educational institutions, and a director for more than 50 for-profit businesses.
"I really believe that teaching is very important. All higher education institutions should help all their faculty to achieve the highest quality of teaching and should reward the best teachers," said Bank, a 2006 Penn State Alumni Fellow. "Sixty years after my graduation from Penn State, I still remember history professor Kent Forster and how wonderful he was. His classrooms were always full. I started to take any course he taught because he was such an outstanding teacher. I would like students to feel as I did with Kent and be inspired to come to classes and learn."
Eric Silver joined Penn State in 1999 as assistant professor and was named associate professor in 2003 and professor in 2010. His teaching focuses on the sociology of deviance, social control and morality, and he conducts research on violence and the mentally ill.
Susan Welch, the Susan Welch Dean of the College of the Liberal Arts, noted, "Eric strives not only to impart facts to students, but rather, he teaches students to think sociologically about the world around them. He helps to provide a new lens to see social structures that we typically take for granted in everyday life."
One of Silver's most impressive classes is the upper-level Sociology of Deviance course, which has a larger than normal enrollment of 170 students. He goes beyond the lecture format and multiple-choice tests by adding facilitated group discussions and guest presenters to spark students' interest and learning. He also uses technology such as a Facebook forum and cellphone texting during class discussions in response to his questions. He also requires weekly written assignments in which students analyze class concepts.
His student evaluations are consistently near perfect with a mean rating of 6.5 to 6.8, out of a possible 7.0 rating. Additional student comments include "Dr. Silver is an incredible teacher. His teaching style makes this one of the most interesting courses I have ever taken here at Penn State." Silver also is is an excellent mentor of undergraduates and employs a number of undergraduate assistants to provide valuable experiences in teaching. The College of the Liberal Arts recognized him with an outstanding teaching award in 2005.
As a recipient of the Bank Outstanding Teaching Award, Silver will give a public lecture on undergraduate teaching this coming academic year and take part in a discussion in the new faculty workshop sponsored by the College of the Liberal Arts. Three years ago, he initiated a Teaching Forum with expert speakers sharing their best practices with the faculty and instructors in the department. In his additional role as associate head of the department, he also mentors faculty and instructors who are experiencing problems with their teaching. One example of his teaching innovation can be seen on his blog at http://www.nonjudgmentday.org/.
"To be recognized publically for doing something one absolutely loves is a true blessing," said Silver. "The generous resources that come with the Bank award will help me greatly in my ongoing efforts to make my classes rigorous, relevant and remembered by students. I will use the award to further integrate innovative technologies into my teaching and to bring new and exciting guest speakers into the classroom to share their experiences with students in a way that brings the sociological study of deviant behavior to life."


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Princeton, NJ – September 19, 2013 – Soligenix, Inc. (OTCQB: SNGX) (Soligenix or the Company), a clinical stage biopharmaceutical company focused on developing products to treat inflammatory diseases and biodefense medical countermeasures (MCMs) where there remains an unmet medical need, announced today that it has been awarded a contract valued at up to $26.3 million by the US Department of Health and Human Service's Biomedical Advanced Research and Development Authority (BARDA). The contract is for the advanced preclinical and manufacturing development of OrbeShield™ (oral beclomethasone 17,21-dipropionate or oral BDP) as a MCM for the treatment of gastrointestinal acute radiation syndrome (GI ARS).
The potential five year contract contains a two year base period, with two contract options that would extend the contract an additional three years. The total award will support the preclinical and manufacturing development activities necessary to successfully navigate and complete the FDA approval process for use of OrbeShield™ to treat GI ARS.
"Securing a highly competitive BARDA contract provides important recognition as to the innovative quality and potential therapeutic impact of our technology," stated Christopher J. Schaber, PhD, President & Chief Executive Officer of Soligenix. "This contract award provides the comprehensive funding necessary to continue development of OrbeShield™ while building upon the growing body of compelling scientific evidence supporting its use as a potential MCM for GI ARS. We thank BARDA for their support and look forward to collaborating closely with them as we advance this technology."
About GI ARS
ARS occurs after toxic radiation exposure and involves several organ systems, notably the bone marrow the GI tract and later the lungs. In the event of a nuclear disaster or terrorist detonation of a nuclear bomb, casualties exposed to >2 Gy are at high risk for development of clinically significant ARS. Exposure to high doses of radiation exceeding 10-12 Gy causes acute GI injury which can result in death in 5-15 days. The GI tract is highly sensitive due to the requirement for incessant proliferation of crypt stem cells and production of mucosal epithelium. The extent of injury to the bone marrow and the GI tract are the principal determinants of survival after exposure to TBI. Although the hematopoietic syndrome can be rescued by bone marrow transplantation or growth factor administration, there is no established treatment or preventive measure for the GI damage that occurs after high-dose radiation. Therefore, there is an urgent need to develop specific MCMs against the lethal pathophysiological manifestations of radiation-induced GI injury.
About OrbeShield™
OrbeShield™ is formulated for oral administration in GI ARS patients as a single product consisting of two tablets; one tablet releases BDP in the proximal portions of the GI tract and the other tablet releases BDP in the distal portions of the GI tract. BDP has been marketed in the US and worldwide since the early 1970s as the active pharmaceutical ingredient in inhalation products for the treatment of patients with allergic rhinitis and asthma. To date, oral BDP has been safely administered to more than 350 human subjects in multiple clinical studies. Oral BDP is also being developed in other GI disorders characterized by severe inflammation such as pediatric Crohn's disease, radiation enteritis and chronic Graft-versus-Host disease (cGVHD).
The FDA has cleared the Investigational New Drug (IND) application for OrbeShield™ for the mitigation of morbidity and mortality associated with GI ARS. OrbeShield™ has also been granted Orphan Drug and Fast Track designations by the FDA for the prevention of death following a potentially lethal dose of total body irradiation during or after a radiation disaster.
About BARDA
The Biomedical Advanced Research and Development Authority within the Office of the Assistant Secretary for Preparedness and Response in the US Department of Health and Human Services, provides an integrated, systematic approach to the development and procurement of critical products needed for public health emergencies. In collaboration with the National Institutes of Health, Department of Homeland Security, and other federal agencies, BARDA plays a key role in the government's efforts to develop MCMs needed to prevent or mitigate potential health effects from exposure to chemical, biological, radiological and nuclear (CBRN) agents and other terrorist threats. Support for OrbeShield™ product development is being provided under a CBRN program to advance technologies and products to treat acute radiation syndrome (ARS). Funding for BARDA's MCM development programs is authorized under the Pandemic and All Hazards Preparedness Act of 2006 (PAHPA) and reauthorized under the Pandemic and All Hazards Preparedness Reauthorization Act of 2013 (PAHPRA). Additional MCM programs are funded by BARDA under the Project BioShield Act of 2004.
About Soligenix, Inc.
Soligenix is a clinical stage biopharmaceutical company developing products to treat serious inflammatory diseases where there remains an unmet medical need, as well as developing several biodefense vaccines and therapeutics. Soligenix is developing proprietary formulations of oral BDP (beclomethasone 17,21-dipropionate) for the prevention/treatment of gastrointestinal disorders characterized by severe inflammation, including pediatric Crohn's disease (SGX203), acute radiation enteritis (SGX201) and chronic Graft-versus-Host disease (orBec®), as well as developing its novel innate defense regulator (IDR) technology SGX942 for the treatment of oral mucositis.
Through its BioDefense Division, Soligenix is developing countermeasures pursuant to the Biomedical Advanced Research and Development Authority (BARDA) Strategic Plan of 2011-2016 for inclusion in the US government's Strategic National Stockpile. Soligenix's lead biodefense products in development are a recombinant subunit vaccine called RiVax™, which is designed to protect against the lethal effects of exposure to ricin toxin and VeloThrax™, a vaccine against anthrax exposure. RiVax™ has been shown to be well tolerated and immunogenic in two Phase 1 clinical trials in healthy volunteers. Both RiVax™ and VeloThrax™ are currently the subject of a $9.4 million National Institute of Allergy and Infectious Diseases (NIAID) grant supporting development of Soligenix's new vaccine heat stabilization technology known as ThermoVax™. Soligenix is also developing OrbeShield™ for the treatment of gastrointestinal acute radiation syndrome (GI ARS) under a $600,000 NIAID Small Business Innovation Research (SBIR) grant. OrbeShield™ has previously demonstrated statistically significant preclinical survival results in two separate canine GI ARS studies funded by the NIAID. Recently, Soligenix announced a worldwide exclusive collaboration with Intrexon Corporation that will focus on the joint development of a treatment for Melioidosis, a high priority biothreat and an area of unmet medical need.
For further information regarding Soligenix, Inc., please visit the Company's Website at www.soligenix.com.
This press release contains forward-looking statements that reflect Soligenix, Inc.'s current expectations about its future results, performance, prospects and opportunities, including but not limited to, potential market sizes, patient populations and clinical trial enrollment. Statements that are not historical facts, such as "anticipates," "estimates," "believes," "intends," "potential," or similar expressions, are forward-looking statements. These statements are subject to a number of risks, uncertainties and other factors that could cause actual events or results in future periods to differ materially from what is expressed in, or implied by, these statements. Soligenix cannot assure you that it will be able to successfully develop, achieve regulatory approval for or commercialize products based on its technologies, particularly in light of the significant uncertainty inherent in developing vaccines against bioterror threats conducting preclinical and clinical trials of vaccines, obtaining regulatory approvals and manufacturing vaccines, that product development and commercialization efforts will not be reduced or discontinued due to difficulties or delays in clinical trials or due to lack of progress or positive results from research and development efforts, that it will be able to successfully obtain any further funding to support product development and commercialization efforts, including grants and awards, maintain its existing grants which are subject to performance, enter into any biodefense procurement contracts with the US Government or other countries, that it will be able to compete with larger and better financed competitors in the biotechnology industry, that changes in health care practice, third party reimbursement limitations and Federal and/or state health care reform initiatives will not negatively affect its business, or that the US Congress may not pass any legislation that would provide additional funding for the Project BioShield program. These and other risk factors are described from time to time in filings with the Securities and Exchange Commission, including, but not limited to, Soligenix's reports on Forms 10-Q and 10-K. Unless required by law, Soligenix assumes no obligation to update or revise any forward-looking statements as a result of new information or future events.


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Nickelback frontman Chad Kroeger is convinced his upcoming nuptials will be "the most unique wedding the planet has ever seen" as his fiancee Avril Lavign is putting a rock 'n' roll spin on the event.
The rocker had a traditional ceremony in mind, but he admits Lavigne has taken control of the wedding plans and wants an unforgettable celebration for her second trip down the aisle.
He tells Men's Health magazine, "We (grooms) get such an incredibly small chunk in terms of what we can actually participate in… I get control over nothing. I just show up. But I'm glad, because she has… traversed these territories before. These are unchartered waters for me. So it's nice to have her to guide me through this.
"She's got great ideas. I would have gone a little too traditional, I think, and she's giving it a real rock 'n' roll edge. The groomsmen won't be wearing piano neckties (but) let's just say she's taking the bull by the horns and steering the ship towards what is going to be the most unique wedding that the planet has probably ever seen."
Kroeger, who announced his engagement to Lavigne in August, insists he never envisioned himself settling down, adding, "There was a time in my life that I thought I would never get married. But this definitely took me by storm. Honestly, it was more my idea than hers to get married. I'm just lucky she said yes."
Lavigne was previously married to Sum 41 frontman Deryck Whibley, and also dated reality TV star Brody Jenner before they split earlier this year.


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Believe it or not, the holidays are almost upon us, which means that the holiday shopping season is also here. With the majority of holiday shopping now taking place online – last year's online gift buying increased 7 percent - shoppers hold the power for whether or not your website has a successful holiday season. The best thing to do to ensure your e-commerce site is ready for the holiday shopping season is to test website performance automatically and frequently. In this slideshow, BlazeMeter's Michael Sage has identified five performance testing tips that will help you meet the holiday rush.
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