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Alendronate to Treat Polyostotic Fibrous Dysplasia and McCune-Albright Syndrome
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
|ClinicalTrials.gov Identifier: NCT00001728
Recruitment Status : Completed
First Posted : November 4, 1999
Last Update Posted : July 2, 2017
- Study Details
- Tabular View
- No Results Posted
- Disclaimer
- How to Read a Study Record
This study will evaluate the effectiveness of alendronate in treating the bone abnormality in polyostotic fibrous dysplasia and McCune-Albright syndrome. In these diseases, areas of normal bone are replaced with a fibrous growth similar to a scar. The weakened bone causes pain and increases patients' risk of bone fractures and bone deformities. Alendronate belongs to a class of drugs called "bisphosphonates," which are approved by the Food and Drug Administration to treat bone weakening, deformity and pain in other medical conditions. It is thought that bisphosphonates might work by slowing the activity of osteoclasts-cells that break down bone.
Patients 12 years of age and older with polyostotic fibrous dysplasia or McCune-Albright syndrome may be eligible for this 3-year study. Candidates must also be enrolled in NIDCR's protocol 98-D-0145 (Screening and Natural History of Patients with Polyostotic Fibrous Dysplasia and McCune-Albright Syndrome).
Participants will be randomly assigned to one of two treatment groups: they will take one capsule a day of either alendronate or placebo (a look-alike capsule that has no active ingredient). They will take the capsules for 6 months, stop for 6 months, then take them for another 6 months and then go off them for 6 months. They will then remain off the drug or placebo for an additional 12 months and complete the study with a final follow-up visit at 36 months. While taking alendronate or placebo, patients will also take calcium and vitamin D to prevent secondary hyperparathyroidism-a side effect of alendronate in which the bone does not release enough calcium.
Patients will come to NIH for a physical examination and blood and urine tests every 6 months and for monitoring of their bone disease, vision, hearing, pain levels, functional evaluation, and photographs every 12 months. Many of the monitoring procedures, including imaging studies and biopsies, are performed for the screening protocol (98-D-0145) and will not be duplicated for this study. During the study periods when patients are taking alendronate or placebo, they will have blood samples drawn by their local physician once every 3 months and sent to NIH to check for secondary hyperparathyroidism.
If at the end of the study alendronate is found to be effective, patients who were in the placebo treatment group will be offered alendronate for a 24-month period.
|Condition or disease
|Polyostotic Fibrous Dysplasia
|Drug: Fosamax (Alendronate)
|Phase 2
Polyostotic fibrous dysplasia (PFD) is a sporadic disorder which affects multiple sites in the skeleton. The bone at these sites is rapidly resorbed and replaced by abnormal fibrous tissue and mechanically abnormal bone. PFD may occur alone or as part of the McCune-Albright Syndrome (MAS), a syndrome originally defined by the triad of PFD, cafe-au-lait pigmentation of the skin, and precocious puberty. The bony lesions are frequently disfiguring and painful, and depending on the location of the lesion, they can cause significant morbidity. Lesions in weight-bearing bones can lead to disabling fractures, while lesions in the skull can lead to compression of vital structures such as cranial nerves.
Currently there are no clearly-defined systemic therapies for this bone disease. Small, uncontrolled trials using the second generation bisphosphonate, pamidronate, suggest that bisphosphonates may be effective. This study is a phase 2, controlled, double blinded trial of the third generation oral bisphosphonate, alendronate for the treatment of fibrous dysplasia. We propose to show that treatment with alendronate will improve bone quality, decrease bone pain, decrease fractures, and, if the patient is referred to the companion bone grafting protocol, will allow for the regeneration of better quality bone.
|Study Type :
|Interventional (Clinical Trial)
|Actual Enrollment :
|40 participants
|Primary Purpose:
|Official Title:
|A Randomized, Placebo-Controlled Trial of Alendronate in the Treatment of Polyostotic Fibrous Dysplasia and the McCune-Albright Syndrome
|Study Start Date :
|August 24, 1998
|Actual Primary Completion Date :
|August 19, 2007
|Actual Study Completion Date :
|May 2, 2011
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
|Ages Eligible for Study:
|6 Years and older (Child, Adult, Older Adult)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
All patients must be concomitantly enrolled in the companion Screening and Natural History protocol.
Any patient with at least 2 active fibrous dysplastic lesions of either the cranial, axial, or appendicular skeleton will be eligible for consideration for inclusion in the study. The diagnosis will be based on evidence typical findings on bone biopsy (performed during the "Screening" protocol). Final consideration for enrollment will depend on diagnosis at the NIH.
Patients must be at least 6 years old.
Patients may be of child-bearing age, but will be expected to be on a nonhormonal form of birth control that gives a 95% protection rate. If a patient becomes pregnant during the course of the study, they must withdraw but will be eligible for re-enrollment upon the completion of pregnancy and lactation.
Patients on previous of concomitant therapy are eligible for enrollment. However, patients who have received previous treatment with a bisphosphonate must wait one year from the completion of the last course before they can be enrolled.
Patient, child or parents unwilling to fully cooperate with the evaluation as outlined in the schedule and consent form and do not give informed consent.
Any sexually active patient that is unwilling to use an appropriate contraceptive associated with a pregnancy-prevention rate of 95% or greater.
Pregnancy is an absolute contraindication to be evaluated or admitted to the study and is grounds for removal from the study. However, patients may be re-enrolled once pregnancy and lactation are completed.
Severe esophageal motility problems may put patients at increased risk for complications from alendronate and are not eligible for the study.
Significant comorbidities such as decompensated heart failure or diabetes mellitus, renal or hepatic failure, or decompensated psychiatric conditions exclude patients from enrollment.
Patients with either a history of sarcoma of the bone or who have a FD lesion that undergoes sarcomatous degeneration while enrolled in either this study or any of the companion protocols.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00001728
|United States, Maryland
|National Institutes of Health Clinical Center, 9000 Rockville Pike
|Bethesda, Maryland, United States, 20892
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
|Responsible Party:
|Pamela G. Robey, Ph.D./National Institute of Dental and Craniofacial Research, National Institutes of Health
|ClinicalTrials.gov Identifier:
|NCT00001728 History of Changes
|Other Study ID Numbers:
|First Posted:
|November 4, 1999 Key Record Dates
|Last Update Posted:
|July 2, 2017
|Last Verified:
|May 2, 2011
Keywords provided by National Institutes of Health Clinical Center (CC):
Bone Marrow Stromal Cells
Bone Turnover
Fibrous Dysplastic Lesion
Polyostotic Fibrous Dysplasia
McCune-Albright Syndrome
Additional relevant MeSH terms:
Fibrous Dysplasia of Bone
Fibrous Dysplasia, Polyostotic
Pathologic Processes
Bone Diseases, Developmental
Bone Diseases
Musculoskeletal Diseases
Bone Density Conservation Agents
Physiological Effects of Drugs


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Harbor Springs
In 1902 Ephraim Shay, famed for inventing the Shay locomotive that revolutionized the logging industry, built an ultra-light rail line – the Hemlock Central – to test his locomotive tinkering and haul lumber to area sawmills. Come summer, resorters climbed aboard in Harbor Springs for 25 cents a ride. Though Shay's "Baby" stopped steaming from forest to shore decades ago, folks still flock to this old-timey town on Little Traverse Bay.
The best way to arrive these days? Pick your pleasure: Motor down from the north through M-119's famed Tunnel of Trees. Bike up the Little Traverse Wheelway (trailscouncil.org). Or drop out of a plane with the parachuting pros at Skydive Harbor Springs (231-330-3483, skydiveharborsprings.com).
Once you're standing downtown, stroll the flowerbox-lined sidewalks and a bevy of chi-chi boutiques – everything from modern art and antiques to furniture, clothes and books. Shop (or covet) till you drop, then aim for great eats: at Cornichon's European Market (248 State St., 213-242-0020), the Gobbler sandwich, and from tiny Tom's Mom's cookies (267 State St., 231-526-6606), a hunk o' homemade Chocolate Chunk. It's time for a woodsy hike and beach picnic at Thorne Swift Nature Preserve (M-119 north 4 miles to Lower Shore Drive, 231-526-6401).
At day's end, sup on a strip at the 1904-established The New York (101 State St., 231-526-1904). Then, when the sun starts sinking into the cobalt-blue bay, do as they've done in Harbor Springs for the last century: head to the shore. – L.T.
Stay the NightBirchwood Inn: Comfortable lodge surrounded by birch trees. Old-type shuffleboard court and heated retro swimming pool. 231-526-2151 or birchwoodinn.com
Highland Hideaway Resort: Bright, contemporary hilltop B&B with on-site winery. Buffet breakfast and afternoon aperitif. 231-526-8100 or highlandhideawayresort.com
Lynda Twardowski is travel editor at Traverse, Northern Michigan's firstname.lastname@example.com
Note: This article was originally published in May 2007 and was updated for the web February 2008.

subset: commoncrawl


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Material Details
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The marchers in Kabul last week were in their teens and early 20s, the kind of zealous, energetic youths Westerners might have hoped would be clamoring for democracy or human rights. Instead, the cause of their protest was caricatures of the Prophet Muhammad, first published last September by a Danish newspaper called Jyllands-Posten, which in the past two weeks have provoked Muslims around the world to denounce not just the offending illustrators but also French newspaper editors, Norwegian diplomats, U.S. troops in Iraq and peddlers of Danish food. In Kabul the protest signs read DEATH TO DENMARK and DEATH TO THOSE WHO...
Fanning the Flames
As the rage over the Muhammad cartoons burns on, TIME explains why the controversy erupted months after the caricatures appeared--and what could have averted the crisis
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we are going to make it count
As in war, chess requires one should preserve what one can, and sacrifice what one cannot.
Even to the sacrifice of the most valuable pieces to win the game."
Rachel Caine
"I'm sick of people telling me it's just a "get over it" situation. Fuck you. You don't know what it's like in my head. "
The Newsroom
"When all the world's a lock, you don't find a key, you become the key."
Rachel Caine
This is about sacrifices and how we manage, or mismanage, the sacrifices we make.
Simplistically … I tend to believe we all know that if you have to give something meaningful up … you should make it count.
We make sacrifices all the time.
Sometimes we don't even want to make a sacrifice … but Life steps in and actually demands we make one <and we have to deal with it>.
The problem is that I would bet <and I am not a betting man> that we squander 90% of our sacrifices. And I suggest that 90% number knowing that this number just doesn't include the small sacrifices … but also some of the larger "life-defining" sacrifices.
Yeah … the larger ones. The larger ones include the kind of sacrifice that can be a defining moment — kind of a crossroads in a way. Now. I purposefully used 'defining' because … well … let's face it … many of us every day schmucks can often lack a certain sureness of our own identity and a sacrifice has a nasty habit of making us face that fact and think about doing something about it.
All of what I just suggested means most of the time we want to make the sacrifice count.
The next problem is with our sacrifice mismanagement.
Almost every one of us has made some personal life changing decision <which included a sacrifice> … and went in 'whole hog' … and failed.
Therefore, we take our sacrifice and then sometimes seek some clarity of self or sometimes seek some collective-type identity by joining some movement or group. We convert our personal sacrifice into some collective 'spirit of shared visions & goals' as a means to not only seek some positive affirmation to our sacrifice but also to … well … hedge our bets.
We know we failed in personal pursuit but believe, if in a group, it will be harder to squander the sacrifice … to not let the sacrifice not count.
I am not going to comment, or criticize, how anyone pursues insuring their sacrifice counts because what matters is insuring that any sacrifice you make doesn't get wasted.
What I will suggest is that we let far too many sacrifices lay wasted in our rear view mirrors. I would argue that a sacrifice is like starting the engine and putting everything into gear … but you gotta supply the gas and keep your foot on the gas pedal and your hands on the steering wheel.
If you doubt that we waste them … start by just thinking about all the 'right things' we associate with sacrifices.
We even have sayings to express our desire to make it count once … well … deciding it SHOULD count:
… in for a penny, in for a pound.
… go big or go home.
… all or nothing.
We say all this shit all the time which means, in our heads, that the implication is to 'go for it' despite the potential time investment, potential energy & effort investment and potential costs investment.
Yes … great intentions.
But … we waste it.
Simplistically most of us will run a 100 yard dash in a 5 mile race.
And then we look at the 100 yards and say "whew, I gave it my all … I went big … I was all in." And for a 100 yards you were. The problem is that the finish line, assuming there is a finish line at all, is … well … there is another … uhm … 8700 yards to go.
Another 87 100 yard dashes.
That's why making sacrifices count is so hard.
Almost everyone will go for it for 100 yards having given a meaningful sacrifice.
And will feel like you gave it a good college try.
A smaller percentage maybe will do the 2000 yards in the race … just suck it up and go for 20 100 yard dashes.
And feel like you gave it a good college try.
And a much smaller, much smaller, percentage of people will do the full 88 100 yard dashes and finish the 5 miles and make the sacrifice really count.
I will say that sacrifices really do come down to you. As in the quote I used upfront … if you make a sacrifice you don't look for a key … you become the key that unlocks "making it count."
All that said about investing the energy … we actually fuck up the whole concept of sacrifice. We fuck it up by suggesting making it count relies solely on energy & focus. But many true sacrifices demand … well … real sacrifices. What I mean by that is there are situations where you have to decide that if you want to do something or get somewhere you have to be willing to make whatever sacrifice will get you there – any sacrifice.
This makes me remind everyone what I noted upfront … chess is a great metaphor.
Many times you sacrifice a rook, a knight … maybe even the queen, the most valuable piece, to win the game.
That is 'going for it.'
That is 'go big or go home.'
It's not just running the entire 88 100 yard dashes but also sacrificing something else <sometimes, not always> to get to where it all really counts.
And maybe that is my point.
We sometimes are fairly flippant with regard to 'sacrifice.'
And other times, when big sacrifices are forced upon us, we are not flippant with regard to our intentions to make it count .. but because we did not choose the sacrifice, it was thrust upon us, the internal engine isn't focused on making it count as hard as if we had actually chosen to make the sacrifice.
This all means 90% of the time we do not really make sacrifices count.
That's a shame.


text:
LINCOLN — An investigation by Vermont state game wardens has let to a 25-year-old Starksboro man being charged with taking a moose out of season.
Game Warden Robert Currier and Sgt. George Scribner responded on Oct. 5 to a report of a moose found dead on Guthrie Road in Lincoln. The wardens determined the moose had been illegally shot. Vermont's firearms moose hunting season was Oct. 20-25 this year.
Further investigation led authorities to cite Shaun E. Rublee of Starksboro in the killing of the moose.
MIDDLEBURY — It was almost two years ago that Beth Pearce was appointed to the position of state treasurer.
Now the Barre Democrat wants to earn the job at the polls on Nov. 6, when she faces Republican challenger Wendy Wilton, the Rutland City treasurer (see relates story).
FERRISBURGH — A transient man serving a lifetime driving ban for alcohol-related offenses crashed his car into a trees off Sand Road in Ferrisburgh on Oct. 27, injuring himself in the process.
Vermont State Police cited Kenneth A. Jennings Jr., 49, for driving under the influence and driving with a criminally suspended license. Police said he was driving a 1990 Chevrolet Silverado southbound on Sand Road when he lost control of the vehicle and went off the west side of the road, colliding with a moderate-size tree.
MIDDLEBURY — Rutland City Treasurer Wendy Wilton likes a challenge. So after helping her hometown get its once-disheveled fiscal house in order, the Rutland Republican now has her sights set on the state treasurer's office. On Nov. 6, she hopes to unseat incumbent state Treasurer Beth Pearce, a Barre Democrat (see related story).
"This is the first time the treasurer's office has been a competitive race in 20 years," Wilton said during a recent interview with the Addison Independent. "There are some big issues at stake."
BRISTOL — Just a few years after a recession-induced slump prompted the closure of several Main Street businesses, downtown Bristol is making a comeback.
This summer marked the opening of Lulu's ice cream shop by the owners of Mary's Restaurant, Danielle Smith's Little Babycakes baby clothing store, and Rory Jackson's painting studio and gallery space.
MIDDLEBURY — Porter Medical Center will enlist the help of its more than 600 employees in finding ways to help reduce its annual energy bill of almost $1 million.
At issue is Porter's participation in a new Efficiency Vermont program that will feature some on-site workshops on what workers can do to reduce power consumption. This will culminate in a contest for the Porter employees who submit the most creative and practical energy-savings tips. Those who submit the top three ideas, as judged by Efficiency Vermont, will receive $50 gift cards to local stores.
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MIDDLEBURY — Matt Rigney developed a passion for fishing during many years of solitary angling in a small boat off the coast of Maine.
Along with the thrill of catching some hefty bluefish, striped bass and other species, Rigney learned about what he called the "power of solitude, about what you see when you sit quietly and observe nature."
FERRISBURGH — The Agency of Transportation has pledged within the next several years to put traffic lights at the Ferrisburgh intersection of Route 7 with Little Chicago and Middlebrook roads, which is in the heart of the town's population center and is near Ferrisburgh Central School.
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text:
Use Facebook and other platforms to target customers at a granular level.
It's been about five years since we started dabbling in social media. At first it was all about the social interaction. Facebook, LinkedIn, and Twitter were starting to gain some traction. I remember opening my Facebook account when there were only 100 million users. Now it is 1.1 billion users, and the landscape has fundamentally changed.
In the beginning, Facebook was just a bunch of college kids posting pictures of their frat parties and other personal shenanigans. It was just fun and games. Over the next few years, as their meteoric user base kept climbing and climbing, the business community woke up and began to take notice. They immediately started to market in the old-school ways by abusing the users with constant pitches, sales, promos, etc. That's still happening to a large degree, and the results are predictably bad. Consequently, businesses will tell you they've tried using social media, but their results were poor to dismal. They are absolutely wrong.
The revolution in social media isn't about posting what you ate for lunch, or where you went on your vacation, or checking in at a certain restaurant. It has much deeper meaning for your business if you use it correctly. Let's talk about realizing the full, revolutionary potential of social media and the steps you need to take to reap the associated benefits.
Social signals and social proof
We'll start with the end in mind. Our goals are two-fold. The first is to maintain a Top of Mind presence with our customer base. This means building out your fan page and connecting with your customers and your potential customers. These are the people with whom you will be conversing. It's helpful to realize that most of your customers won't be ready to buy anything from you when they see your posts. But they will probably know someone who they can recommend you to that does. This is where the Top of Mind comes into play. You want your services to be at the forefront of their thoughts.
This is pretty straightforward. What's less obvious is what we're looking to do. You never want to engage in blatant, in-your-face selling. Your goal is to present yourself as the pre-eminent expert or authority in your market. You want to be the one everyone goes to. To achieve this, you need to understand social signals and social proof.
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text:
The All Blacks squad to tour Europe has been named and will leave on Thursday, but Sky Television has yet to confirm whether they will be broadcasting the match.
Sky TV and an international brokerage company negotiating on behalf of the Italy Rugby Union have yet to agree on a price for the rights, Sky spokeswoman Kirsty Way said.
Next month's Skywatch magazine cover features cartoons representing an All Black and players from Scotland, England and Wales, but an Italian is conspicuous by his absence. That also applies to the listings - there is no mention of the match against Italy in Rome which kicks off at 3am on Sunday, November 18 (NZT).
On the Rugby Channel that morning there is a scheduled live screening of England v Australia at 3.20 and later the France v Argentina test at 8.50am.
"We're in negotiations, Sky has put a bid for the match, we're very keen to show it, but we have not received confirmation that we have been successful," Way said.
"It's not particularly unusual. We can still get sports rights right up to the last week, last day, even hours before. It's not our preference because it limits the amount of time you've got to finalise production and promotion of the match."
The All Blacks last played in Italy in 2009, a 20-6 victory in Milan, but Way said she couldn't recall rights negotiations being an issue then.
She said she was struggling to recall a test involving the All Blacks in the professional era not screened by Sky.
"We know that Sky Sports fans and most New Zealanders would be very keen to see the match.
"It's certainly not [an] insignificant [cost] for All Blacks rights. Although the match is on at three in the morning, it's not the best time for our subscribers but it's the All Blacks," she said.
Dan Coles and Tawera Kerr-Barlow were the only uncapped players named in the All Blacks squad of 32 today, with coach Steve Hansen suggesting he will mix up his team for the first test against Scotland on Monday, November 12 (NZT) and Italy six days later.
The All Blacks finish their tour with matches against Wales in Cardiff and England at Twickenham.


text:
Gallery: 2014 IRONMAN 70.3 Auckland Asia-Pacific Championship
Photo credit: Delly Carr
A blistering run by Jan Frodeno propelled the 2008 Olympic champion to his first endurance-distance victory as the tall German destroyed a world-class field to clinch the IRONMAN 70.3 Auckland Asia-Pacific Championship title.
In the final 100 m he milked the applause of the fans in a sun-drenched Auckland Viaduct Harbour.
A sensational 21.1 km run by former world duathlon champion Catriona Morrison helped overturn the healthy lead of defending champion Annabel Luxford after the bike to clinch the women's title.
Morrison crossed the line in 4:14:41, 46-secons clear of Luxford, a former ITU world U23 champion.


text:
I drove the over 250 miles from my home in Edwardsville, IL, to attend the SQL Server 87 in Louisville, KY. Even though I am not a fan of driving, the beautiful fall day with lots of colorful trees made the drive more of a pleasure than it might have been another time of the year.
I arrived in plenty of time to attend the speaker dinner and hang out with some of the speakers after the dinner. Even though I had just enjoyed spending time with my SQL friends at the PASS Summit, it was wonderful getting to see a few of them once again in Louisville.
Every SQL Saturday is unique. This particular one struck me as being a very warm, friendly event with a sense of humor. Many of the attendees, volunteers and speakers were in costume and there were also a few kilts. Like many other SQL Saturdays, this event had no shortage of MVPs, including Tim Ford, Tom LaRock, Allen White, Rodney Landrum, William Pearson III, Kevin Boles, Kevin Kline, Karen Lopez, and John Magnabosco. I hope I am not missing anyone here, but you get the idea: This was a star-studded line up.
Once again, I organized a Women in Technology Panel at lunch. Continuing the theme from the Summit by including a man on the panel, we made a last minute substitute adding Kevin Kline in the place of Karla Landrum. Karla was in attendance, in her Wonder Woman costume, but stepped aside to let Kevin join. We had almost an almost 50/50 split in the room, and I think that always makes for the best discussion.
I was the moderator, and the panel consisted of Sarah Barela, Karen Lopez, and, of course, Kevin Kline. Our topic was "Encouraging the Next Generation," and the panel made some fantastic points. Karen brought her Techno-Barbie and explained how her Barbies are conversation starters, but even Computer Engineer Barbie lives an isolated life in a cube. Television shows are starting to show better technical female characters, but there is a long way to go.
Much of the discussion focused on what makes women interested in technology. Sara mentioned that many women want to work on something that very visibly makes a difference, that helps people, or even changes the world. Women seem to be more interested in database administration than jobs like SAN administrator. All of these careers are important to the business, but it is much easier to see how the DBA job directly affects others.
Young women are usually very social. How can we get middle or high school girls interested in science and technology when they are often the only girl in the class? Kevin mentioned a blog he recently wrote about how many successful women in IT were not as social as kids and considered themselves unique. I can relate to that as did the other panel members.
Overall, it was a fantastic panel and a fantastic day. Mal did a great job, and I look forward to attending the next Louisville SQL Saturday.
Here are some resources for kids programming:


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Common Core Roundtable Slated For Casper And Cheyenne [AUDIO]
State House Representative Tom Reeder started looking in to Common Core standards and their effect on Natrona County and State schools in March. He found more questions than answers and decided to do something about it. Teaming up with Amy Edmonds in Cheyenne and The Wyoming Liberty Group, they are bringing a roundtable discussion to Casper and Cheyenne next week.
Representative Reeder joined Brian Scott to talk about the events,
Casper's meeting on Tuesday August 20th, will take place at the Parkway Plaza from 6-8 PM. It will be moderated by Representative Reeder. Cheyenne's roundtable will be at the Little America Hotel from 6-8 PM on Wednesday August 21st and will be moderated by Amy Edmonds.
Both discussions will include experts from around the country and Wyoming.
Dr Sandra Stotsky will be on hand and is credited with developing one of the country's strongest sets of academic standards for K-12 students as well as the strongest academic standards and licensure tests for prospective teachers while serving as Senior Associate Commissioner in the Massachusetts Department of Education from 1999-2003. She is also known nation-wide for her in-depth analyses of the problems in Common Core's English language arts standards.
Joy Pullman is a research fellow of The Heartland Institute and managing editor of School Reform News, a national monthly publication. She previously was the assistant editor for American Magazine at the American Enterprise Institute. She is also the 2013 recipient of a Robert Novak journalism fellowship for in-depth reporting on Common Core national education standards.
Also Christy Hooley, a Wyoming educator brings her experience and expertise to the discussion.
For those that would like to attend you are asked to preregister by calling 307-632-7020. There is no cost but organizers are looking to get a head count to assure ample space in the meeting rooms.


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Day three of the Dakhla Kiteboarding World Cup brought the continuation of consistent wind matched with the area's favorable flat water and wide-open beach. Motivating riders to push the limits at every opportunity, the new judging system provided an interesting day of learning adapted to the fresh way of competing.
Competitors, therefore, attempted and executed their very best tricks and most powered maneuvers. With Robinson Hilario, Liam Whaley, and Stefan Spiessberger initially advancing in the early afternoon's first heats, others such as Marc Jacobs and Kevin Langeree competed in especially close encounters.
As the day progressed, the competitors continued to execute memorable maneuvers, from a Front 15 and a Double S-1 to a rare Slim 7. On average, riders completed 10 tricks, with the highest single score of the day earned by Pastor, who executed a 315 rated at 9.1. In the day's final heat, with the sun nearly departed and the wind holding on, Youri Zoon and Alex Pastor battled it out – Pastor attained an impressive average of 7.8 points per trick, which translated into the eventual win. Zoon averaged 7.0 per trick. Marc Jacobs and Alberto Rondina also competed in the loser's final heat with a difference in scores of only 0.5.
The women finally had their first chance to compete on this day in the later hours of the afternoon. Bruna Kajiya won the final single elimination, while Karolina Winkowska executed the highest scoring women's trick of the day – an 8.8 Back Mobe. One of the biggest upsets of the Dakhla tour stop so far played out between World Champion Gisela Pulido against newcomer Manuela Jungo. Pulido lost the heat to Jungo, who displayed incredible determination and skill in a challenging 7 minutes of competition. Reflecting on the heat, Manuela commented that she had come well-prepared and made a point to complete the full 7 maneuvers for the best chance of winning.
The first stop of the 2012 PKRA will continue tomorrow with similar conditions expected. Spectators look forward to the highest possible level of skill, with competitors spending the 4th day in Dakhla in full competition mode.


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Patrick Cockburn reporting from Damascus:
It is one of the most horrifying videos of the war in Syria. It shows two men being beheaded by Syrian rebels, one of them by a child. He hacks with a machete at the neck of a middle-aged man who has been forced to lie in the street with his head on a concrete block. At the end of the film, a soldier, apparently from the Free Syrian Army, holds up the severed heads by their hair in triumph.
The film is being widely watched on YouTube by Syrians, reinforcing their fears that Syria is imitating Iraq's descent into murderous warfare in the years after the US invasion in 2003. It fosters a belief among Syria's non-Sunni Muslim minorities, and Sunnis associated with the government as soldiers or civil servants, that there will be no safe future for them in Syria if the rebels win. In one version of the video, several of which are circulating, the men who are beheaded are identified as officers belonging to the 2.5 million-strong Alawite community. This is the Shia sect to which President Bashar al-Assad and core members of his regime belong. The beheadings, so proudly filmed by the perpetrators, may well convince them that they have no alternative but to fight to the end.
The video underlines a startling contradiction in the policy of the US and its allies. In the past week, 130 countries have recognised the National Coalition of Syrian Revolutionary and Opposition Forces as the legitimate representatives of the Syrian people. But, at the same time, the US has denounced the al-Nusra Front, the most effective fighting force of the rebels, as being terrorists and an al-Qa'ida affiliate. Paradoxically, the US makes almost exactly same allegations of terrorism against al-Nusra as does the Syrian government. Even more bizarrely, though so many states now recognise the National Coalition as the legitimate representative of the Syrian people, it is unclear if the rebels inside Syria do so. Angry crowds in rebel-held areas of northern Syria on Friday chanted "we are all al-Nusra" as they demonstrated against the US decision.
More on that video:
I have not met a Syrian in Damascus who has not seen it. It is having great influence on how Syrians judge their future, but the mainstream media outside Syria has scarcely mentioned it. Some may be repulsed by its casual savagery, but more probably it is not shown because it contradicts so much of what foreign leaders and reporters claim is happening here.


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Deborah Milner
Deborah Milner is a British fashion designer. Originally from London, Milner began her fashion career at Saint Martin's School of Art, where she graduated with a degree in Fashion Design in 1987. Milner's talent and thirst for knowledge led her to continue her studies at the Royal College of Art, where she graduated with an additional Fashion degree in 1990.
With a strong educational foundation as her launch pad, Milner established her own couture atelier in 1991, creating original pieces in collaboration with leading names in the fashion industry, including London's Philip Treacy. From fashion shows and editorial work to music album covers, Milner soon became known as 'London's best kept secret for extraordinarily beautiful designs' and unconventional sculptural shapes.'
From 2004, Milner worked with the late Alexander McQueen as a senior pattern cutter—using her talent for creating beautiful, architectural shapes to prepare show pieces in Paris. In 2003, Deborah traveled to Brazil, where she spent a year developing environmental sustainability initiatives to help preserve the country's vast natural resources. In 2005, Milner partnered with the Aveda Corporation to create eight original couture dresses under the label 'Ecocouture'.
Milner's work has been featured in top publications including: American and British Elle, Harper's Bazaar, American, British, Italian and Brazilian Vogue, L'Officiel, Russian Playboy, Tatler, The Face, The New Yorker, International Herald Tribune, The Guardian, The Independent, The Evening Standard, The Financial Times, The Telegraph, The Times, The Sunday Times, The New York Times and Women's Wear Daily.
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Sixteen Little Giants Earn All-NCAC Honorsby Brent Harris • November 22, 2005 Share:
Sixteen Wabash football players have been named to the 2005 All-North Coast Athletic Conference football team.
Senior quarterback Russ Harbaugh (Evansville, IN/Bosse), in addition to being named the NCAC Offensive Player of the Year, was a First Team selection at quarterback. Joining Harbaugh on the All-NCAC First Team is his roommate and fellow senior Eric Summers (WR/Indianapolis, IN/Cathedral). Also selected to the First Team on offense were linemen Jake Koeneman (Indianapolis, IN/Brebeuf) and Patrick Millikan (Newburgh, IN/Castle).
Wabash players earning First Team All-NCAC honors on defense are Jared Lange (SO/DL/Terre Haute, IN/North), Tamarco White (SR/DL/Flora, MS/Madison Central), Aaron Selby (SR/LB/Crawfordsville, IN/Southmont), Tim Parker (SR/LB/Indianapolis, IN/Warren Central), Adrian Pynenberg (SO/LB/Montgomery, IL/Oswego Community), and Josh Foster (SR/DB/Indianapolis, IN/Ben Davis).
Second Team All-NCAC selections included Geoff Walker (JR/WR/Schererville, IN/Lake Central), Brandon Barkley (SR/OL/Darlington, IN/North Montgomery), and Will Certain (JR/OL/Prescott Valley, AZ/Paradise Valley). Walker earned Second Team honors as both a wide receiver and a return specialist.
Senior running backs Brandon Roop (Newburgh, IN/Castle) and Chris Ogden (Schererville, IN/Lake Central) and junior defensive lineman TJ Schaffer (Odon, IN/North Daviess) earned Honorable Mention All-NCAC honors.
Harbaugh earned his first All-Conference honors after leading the league in nearly every passing category. He became the first Wabash quarterback to throw for more than 3,000 yards in a season and is closing in on the NCAC records for passing yards and completions in a season.
Summers led the NCAC in receiving yards per game with an average of 78.0 and was second in receptions per game with 58 in 11 contests. This is his first All-NCAC selection.
Koeneman (left) earned his first All-NCAC honors, while Millikan (right) picked up his second All-NCAC award after being selected to the 2004 Second Team. Both are part of a Wabash offensive line that has produced the 18th-best mark for total offense in the nation (463.2 ypg), 10th-best passing offense (316.8 ypg), and 30th-best scoring offense (35.6 ppg).
Lange is fourth on the Little Giants' team in tackles with 44, helping Wabash to become the fourth-best scoring defense in Division III (9.4 ppg allowed), fifth in rushing defense (67.8 ypg allowed), and 12th in total defense (249.2 ypg allowed). Lange is also second on the squad in tackles for losses with 12 totaling 40 yards.
White, a senior defensive lineman, was a First Team selection last year, as well. This season he has compiled 25 tackles, 8-1/2 tackles for losses totaling 33 yards, and 2-1/2 sacks for 18 yards.
The linebacker corps of Selby, Pynenberg, Parker, and Foster has been one of the strengths of the Wabash defense all season. Selby (top left) earns his first All-NCAC honors after recording 43 tackles, 7-1/2 tackles for losses of 30 yards, two sacks, and one interceptions despite missing the Ohio Wesleyan game and a portion of the Oberlin game with a broken foot. Pynenberg (top right) leads the Wabash defense for the second consecutive season with 88 total tackles, 20 tackles for losses of 70 yards, seven sacks for 37 yards, and three interceptions. Parker (bottom left) was a First Team All-NCAC selection last season. This year he is second on the team in tackles with 54. He has also recorded 5-1/2 tackles for losses of 165 yards, and two sacks for nine yards. Foster (bottom right), a 2003 and 2004 First Team honoree who split time at linebacker and defensive back for Wabash, is third on
the team with 46 tackles. He also has six tackles for losses of 20 yards, two interceptions, and one sack.
Barkley Certain Ogden Roop
Schaffer Walker
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- Commencement 2019: 'You Are Possibilities'
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How to Upgrade / Downgrade a cPanel account using WHM
This article pertains to WHM, a feature only available to VPS Hosting, Dedicated Hosting, and Reseller Hosting users. Shared Hosting users do not have WHM access. If you are looking or more information on how to upgrade your InMotion Hosting account, most likely you're looking for this article: How to Upgrade / Downgrade your Hosting Plan within AMP
If you setup packages within WHM and used them when creating cPanel accounts, you can easily use those same packages when upgrading / downgrading accounts. For example, if you have one package that offers 1 addon domain while another offers 10, instead of manually adjusting this number, you can upgrade the cPanel account to the new package. This is very helpful when other values (not just addon domains, but maybe mysql databases or diskspace) will be adjusted as well.
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Berkeley Township Is Throwing a Big Thank You Football Party
Berkeley Township is hosting a big football party to show appreciation to first responders, public works and sanitation staffers who served during and after the super storm.
The event billed as "A Day to Say Thank You", is being held this Sunday at the Moorage Baseball Complex in the RJE JR Volunteer Community Center and is being hosted by both Berkeley Township and the township little league. Little League President Bob Everett says he and the Mayor came up with the idea during a recent meeting.
"Just started hearing all of the stories about the extreme amount of work all of our public works employees were doing, our firefighters with long 16 hour days, clearly going above and beyond their normal call of duty. You know, a lot of our first responders, anyway are volunteers."
Everett says the "football party" will feature several large screen HDTV's, kids activities and food donated by local restaurants from 12:30 to 6 p.m.
In a press release, Mayor Carmen Amato says "the last few weeks have been unlike anything our township has faced in the past. The council and I, as well as our residents, are very appreciative of the hard work all of our employees and volunteers have done."
Officials say all proceeds and food are being donated and no public funds are being used. They are accepting monetary donations, pot luck dishes and supplies for the event. They can be made to the Berkeley Little League, PO Box 172 Bayville, NJ 08721. Excess funds are to be donated to storm relief.


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Star athletes on major-market teams make a lot of money. That's not new.
Lesser-known players on struggling or small-market teams, on the other hand, can't quite command the big bucks. That's not new either.
But the disparity between the haves and the have-nots, or in this case, the paids and the paid-nots, has never seemed wider than the 2013 season, which opens Sunday.
Yankees third baseman Alex Rodriguez won't be hitting the field Sunday, or probably any day for the first half of the season, but he'll still get paid his incredible $30 million salary.
A-Rod, the highest-paid player in major league baseball in 2012, makes more in a year than the entire roster of the Houston Astros.
And he's not the only one: the Astros' $25 million payroll is also smaller than Johan Santana of the Mets ($25.5 million) and Cliff Lee of the Phillies ($25 million).
Major League Baseball imposes a luxury tax on teams whose payrolls substantially overrun the rest of the league, first implemented in 2003.
In 2011-2013, the threshold was $178 million, which the Yankees overpaid by $20 million in 2012. In fact, in the 10 years since the MLB began collecting the luxury tax, the Yankees have paid more than 90 percent of all fines imposed.
"The goal of the team every year is to do what's necessary to field a championship team," Yankees President Randy Levine said. "That goes for this year and, as Hal Steinbrenner has said, next year and every year going forward."
Coming off a season in which they lost a league-worst 107 games, the Astros are in a rebuilding year. But Forbes assesses the Houston franchise's value at $626 million, with the team turning a profit.
"Payrolls under $50 million is just a slap in the face to their fan base," said Julie Wechter Beddow, on ESPN. "All teams make more then that from the private and shared TV contracts. Teams like the Marlins and Astros just field cheap teams to pocket the extra money."
New York is projected to have an opening day roster salary of $228 million in 2013, likely leading the league for the 15th consecutive season.
More than $90 million of that -- Rodriguez's, Mark Texeira's, Derek Jeter's, Curtis Granderson's and Phil Hughes's salaries combines -- will start the season on the disabled list.


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Saturday, May 17, 2008
Polka Dot Jumbo Yo-Yo Bliss
I'm sure by now you have figured out that my stylemark and passion has everything to do with fabric yo-yo's. This quilt consists entirely of all that I adore.
I know that many of you have made rag quilts before. If you are willing to deal with the massive amount of clipping that is required and the piles of dust that it creates, this is a quick and easy quilt to produce.
I have chosen to include my hallmark jumbo yo-yo flowers to highlight this bright and cheery quilt. I'm sure you already know that I have a passion for polka dots by the title of my blog. I thought that combining both of my loves into one quilt would take me to seventh heaven and I was right. In my opinion, it cannot get any better.
I plan to share more polka dot jumbo yo-yo flower projects in the coming week so please stop by if you can.
If you haven't been able to read far enough into my blog, you may have missed several yo-yo ideas. Have you seen my jumbo yo-yo quilt and tutorial before?
I hope that it inspires you to start a quilt of your own.
Another tutorial that I have put together is one that shows you how to attach a fabric yo-yo to your project by sewing machine. I will be bringing portions of it back to this page directly under this post for those of you who may have missed it. This method was used to attach the jumbo yo-yo flowers to my quilt and is something that I know you will find very useful in your projects too.
I would like to thank everyone who has visited my blog and especially to those that leave comments. I'm really sorry that I haven't been able to get back to you individually but please know that I love hearing from you. You really are a bright spot in my crazy hectic world. Thank you, thank you, thank you!
Have a great weekend.
***This tutorial is intended for personal use only.***
I would like to show you how I have been attaching fabric yo-yo's to my projects with this tutorial. I have been doing it this way for over 25 years. When I first started attaching yo-yo's to projects, it was always difficult to keep the ends from flipping up or if I tacked them down, the stitches would always show. Instead of hand-tacking a completed yo-yo to a project, I use the sewing machine to do the initial anchoring prior to gathering the yo-yo.
This tutorial is designed to show you how to create a 2-1/4-inch completed yo-yo. You can increase the size and make them the size of a bowling ball or larger if you wish.
Here goes...
The first step is to cut a 5-inch fabric circle.
Please note that a 5-inch fabric circle will make a 2-1/4-inch yo-yo.
Since the yo-yo will end up being 2-1/4 inches, trace a 2-1/4-inch circle in the middle of the fabric yo-yo on the wrong side. It should look like this:
Place the right side of your yo-yo circle to the right side of your project with the yo-yo side facing up. Pin in place. It should look like this:
Use your sewing machine to stitch completely around the circle you just drew. You may also hand stitch around the circle if you prefer.
Now, to close the yo-yo, take needle and thread and hand sew using a 1/4-inch running stitch. Make sure to turn the raw edges in 1/4-inch as you sew. It will look like this:
Pull the thread tight and knot off. This is your completed yo-yo attached to your project. This yo-yo isn't going anywhere. It won't lift up on the edges or shift and become lopsided.
Quick, easy and no dealing with the dreaded hand tacking left to do at the very end of your project.
18 comments:
- Pat said...
What a great idea. Thanks for sharing.
- Sat May 17, 08:50:00 PM 2008
- Pat said...
Thanks for stopping by. I will enter you in the drawing. I have been to HI only one time. It is beautiful. I have a friend that lives in Mililanitown. Is that anywhere near you?
- Sat May 17, 10:50:00 PM 2008
- Marit said...
I love all the beautiful flowers and yo-yos you are making. They are so cute, and so many! I think I willl try your tutorial one day.
- Sun May 18, 01:59:00 AM 2008
- Elly D said...
This is a great idea! I just wish I'd seen it sooner, lol. Before I tried hamfistedly to re stitch the yoyos on my Rabbit Patch quilt. I will know for another project. thank you for sharing..
I love your blog and glad I stumbled on it... Elly
- Sun May 18, 02:31:00 AM 2008
- Jackie said...
Hi Lettie, Wow! I am just getting caught up on all my blog reading and my oh my you have been extremely busy. Thanks for sharing your yo-yo's and the quilt you made with them. Beautiful!! Also, I love the flowers that you have made, they are wonderful. Thanks for the tutorials!
Have a great weekend!
- Sun May 18, 04:41:00 AM 2008
- annemarie said...
Lettie - Your quilt is to die for - simply out of this world - so cheery and fun!!! I still have my eye on your owl - is it your own pattern or one available to buy by mailorder? Your talent still amazes me.
- Sun May 18, 05:07:00 AM 2008
- sweetiepie said...
Lettie - I love the quilt! You do such beautiful work! Thanks for including the neat tutorial. I can't wait to see your new yo yo projects! Thanks for sharing. Joyce in Iowa
- Sun May 18, 05:29:00 AM 2008
- MouseChirpy said...
Hi Everyone!!! (waving madly)
I hope your weekend is going great. Thanks for stopping by my blog today.
Anne, I found a tutorial for you on how to create an owl. It's similar to the one that I use.
Have a fabulous Sunday.
- Sun May 18, 12:25:00 PM 2008
- MouseChirpy said...
For some reason that link didn't work. Try this one...
- Sun May 18, 12:28:00 PM 2008
Lettie, thanks so much for the tutorial and the great quilt! You are definitely an inspiration.
- Sun May 18, 08:28:00 PM 2008
- rowena said...
Coming from an amateur's point of view, that rag quilt actually looks difficult (and time-consuming)! You never fail to amaze Lettie...what talent!
- Mon May 19, 12:56:00 AM 2008
- Mom2fur said...
Oh, my gosh, that just jumps right out at you. It's gorgeous! I can't imagine the hours of work that go into something so beautiful.
Hey, I'm doing an ABCs of creative blogs and I wrote about you this morning--you are my "P" blog! Hope you can stop by for a visit.
- Mon May 19, 05:33:00 AM 2008
- Darlene said...
That's the cutest rag quilt I've ever seen. It's absolutely adorable.
- Mon May 19, 08:07:00 PM 2008
- Marilyn R said...
What a fantastic way to stitch a yo yo down! Thanks for sharing it!
- Tue May 20, 08:48:00 AM 2008
- Stephanie said...
Love the bright colors and the scattered yo-yos on it! Great idea. I haven't tackled a ragged edge quilt yet, but am thinking about it. Was this one flannel?
- Tue May 20, 09:14:00 AM 2008
- Netter said...
You know, its because of your yo-yo tutorial that I found your blog and all the pretty things you make!
I just want to wrap myself up in that rag quilt and sink into a peaceful slumber. ZzzzZzzzZzzz.
- Thu May 22, 09:16:00 PM 2008
- Goodlikeamedicine said...
I just found this tutorial after googling, and I'm all into the "twirly skirts" now and sewing them for my daughters... these will be great embellishments for them! Thanks for the great practical "stay in place" tip!
- Mon Sep 08, 11:33:00 AM 2008
- Kathy I said...
How did you create the yo-yo flowers with the leaves, i.e. the ones you attached to your rag quilt? Did you attach the yo-yo's on the quilt via machine or by hand? Thank you!
- Mon Aug 29, 09:10:00 AM 2011


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text:
iGotWork necesitaba un nuevo diseño de página web y lanzó un concurso de diseño en 99designs.
Un ganador ha sido elegido entre 28 diseños de 10 diseñadores freelance.
I'll select THE BEST illustration image of the new front-page as THE WINNER.
Hi my name is Andreas. I represent a high-class retailer of Persian carpets and furniture. My job is to create new web pages for the company and find the best alternative design.
Persian carpets and antique furniture for the private market. The products are stylish, with a distinct character such as the Persian geometrical design and colors.
The consumer has a taste for elegance, with a clear sense of quality and an interest in furniture and interior design.
REQ #1: Create an illustration of a webpage design that represents the unique quality and character of the products.
A calm "wow-effect", where the quality and texture of the product is in focus..
The designer of the chosen mockup will get the full company details and illustration graphics + link to the current website.
The designer of the chosen mockup must create the full web page-design, including:
- Final front-page design
- Product category level design
- Specific product design (last level)
- General page design for other pages, such as contact page, about us page and others.
- Remember: USABILITY - USABILITY - USABILITY
Ps. the $750 is not just for the mockup... It's for the REQs listed above.
NB! We also have some photos from their shop, please use some of these as active elements in the design. The photos can be downloaded at this url: http://baggy.no/stash/Teppebutikk.zip (151mb!)