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Another year will soon be behind us, and what a year it's been. Economic turmoil, tepid consumer spending, layoffs, wary lenders, clubs closing, club owners delaying purchasing. And that doesn't even include whatever the year held for you personally.
Now is as good a time as any to sit back and think about what you've learned this year—because if you haven't learned anything, then your struggles have been for naught. Here's what I've learned:
Never rest on your laurels. If you think you are doing well and don't need to improve, you're in for a rude awakening. You must stay on top of the future, anticipate what's to come and adapt.
Change is constant—and that's not always a bad thing. As comfortable as the status quo may be, change keeps things from getting stale, and it provides an opportunity for growth.
Fear can trap you. Making decisions—or shying away from making decisions—because of fear often causes you to skip out on challenges that, had you accepted them, would have strengthened you or your business. Worse yet, it can cause you to miss tremendous opportunities.
Keep at least one challenger in your life. Someone who brings a different point of view to your discussions can allow you to expand your view of business and the world. In addition, one good competitor causes you to step up your game, making your business better.
Surround yourself with support. Good friends and staff members are invaluable when times are tough and the workload is heavy. Empower those people to do what they are good at so your life is easier and your business is healthier. In turn, be their support when they need it.
This is the new norm, at least for now. The money you had to cut from your budget and the staff you had to lay off are not coming back anytime soon. You'll need to let go of some of the less important things on your plate. You'll also need to work smarter and as a more cohesive group to get the results you want.
Sometimes, no matter how hard you try and how much you want something, you will fail. Evaluate what went wrong and what you should do differently next time. Then, set another goal and go at it with the same vigor as before.
Offer a kind word and a smile to brighten someone's day. No matter how gloomy you think things are, don't spread around that gloom. Finding something positive to say instead of complaining brightens the gloom a bit for everyone. Mentioning to members that you've noticed their weight loss and encouraging them to keep it up will make them beam because you noticed them and their efforts. Praising staff members for a job well done may not substitute for your inability to offer a raise, but it shows that you notice and appreciate their efforts.
Few things are as bad as they seem. Everything usually works out, even if it's not exactly as you initially planned. Often, surprising solutions present themselves when you keep an open mind and an open ear to those around you.
Keep your moral compass. Even when you are tempted to give in to the easy but suspect option, hold your ground. No one wants to be associated with someone who sells out easily.
Those are just some of the lessons I learned this year. I bet many of them are ones you can relate to as well.
Pamela Kufahl is editor of Club Industry magazine. This is her First Word column from the December 2010 issue.


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Denton - Personal Trainer
Personal Trainer (Self Employed) - Denton
Are you qualified to a minimum REPS level 2 recognised standard and hold a current first aid certificate?
Ready to 'Sweat!' with the best?
Sweat! Union Gym is the new face of friendly fitness, shaking up the fitness industry with our innovative brand of training and member service. From the warm, welcoming reception through to the clean and fully equipped facilities of the gym. We want you to inspire and motivate our members, helping them achieve their goals through all we have to offer including personal training.
Sweat! Buddies (personal trainers) are the heart of our awesome fitness product, helping our members achieve their goals. We are on the lookout for inspirational fitness leaders to take Sweat! to the forefront of the fitness industry and delivering an unrivalled gym experience.
So…Are you fun, fearless (willing to think outside the box!) and, of course, into fitness. Possess a great, outgoing personality with an ability to talk to people from all walks of life? Then we would like to hear from you!
All PT income you generate is 100% yours, we do not take a 'cut'. All we ask is that you provide us with 15 hours of your time to support our gym members. Offering them inductions, classes and support, plus keeping our club looking and running amazing with a some cleaning and maintenance.
- 100% PT income - £36/hour
- £35k per year - Full time
- Only 15 hours of gym floor time (other rent options available)
- Full uniform provided
- Full use of gym facilities including air-conditioned Group Ex studio
- Technogym CV and resistance kit plus free weights and a large range of functional training kit
- Business Starter Pack – all you need to get started and build a successful business.
- Ongoing training – we have a dedicated support system to help you be the best PT you can be, building and retaining a successful business
- Marketing and social media presence – we will promote you and advertise you across all social media networks and online via our dedicated website
You may either fulfill 15 hours of quality Sweat! support to our members each week or pay us rent - choice is yours!
Ready to Sweat!: Sound like your thing or want to know more?
Send your CV along with a brief comment on why you would make a fun & fearless Sweat! Buddy

subset: commoncrawl


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North West Durham
The MP for this constituency is Laura Pidcock (Labour). So far, 245 people have signed up to HearFromYourMP in this constituency. To discover everything you could possibly want to know about what your MP gets up to in Parliament, see their page on our sister site TheyWorkForYou.
- We have sent this MP 0 messages so far in this Parliament, asking them to send an email to their constituents. We will automatically email them when the list in this constituency reaches 300.


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Location : Totescore nr. Uig, Isle of Skye. IV51 9YW
Accomodation : 4 Bedrooms / 8-10 Guests
A substantial architect designed, split-level detached house with panoramic sea views to the Western Isles. Luxury accommodation in quiet secluded surroundings.
AUTUMN/WINTER BREAKS (3 nights and over)... available NOW!
Location : Duntulm, Isle of Skye. IV51 9UF
Accommodation : 3 or 4 Bedrooms / 6-8 or 8-10 Guests
A terrace of three substantial cottages, can be booked individually or together for groups of up to 20 persons.
Magnificent sea views to the Outer Hebrides, the rear overlooks picturesque Loch Cleat.
AUTUMN/WINTER BREAKS (3 nights and over)... available NOW!
Location : Flodigarry, Isle of Skye. IV51 9HZ
Accommodation : 3 Bedrooms / 6-7 Persons
Generous detached house with private garden superbly situated above the crofting township of Flodigarry, near Staffin.
Sheltered by the famous Quiraing mountains, Altavaig enjoys magnificent panoramic sea views across the Minch to Wester Ross.
Newly refurbished to a high standard...available Spring 2018
remote yet accessible...
Family owned and run
our five self-catering holiday cottages on the Isle of Skye are a holiday haven for escapees from the 'real world'
Recently renovated
all the properties are in wonderful coastal locations on the beautiful Trotternish peninsula and have superb sea views.
Get away from it all ~
be active or just relax. Whatever you do you will be drawn by the magic which makes so many visitors come back to stay with us on Skye time after time.
Well behaved pets are welcome.


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The Super Bowl-bound Baltimore Ravens get their name from the poem "The Raven" by Edgar Allan Poe, making them the most literary NFL team. They can thank the people of Baltimore, who chose the name during a poll conducted by the Baltimore Sun.
The radio show "Studio 360" wonders what it might be like if every team were equally inspired by an author. Forget the animal predators and valiant warriors that currently serve as mascots, and instead change every NFL team to something you might find in a library.
Some of the suggestions, so far:
The Detroit Elmores -- for hometown writer Elmore Leonard.
The San Francisco Dharma Bums -- for the novel by Jack Kerouac.
The New Orleans Confederacy of Dunces -- for the novel by John Kennedy Toole, which is set in the city. Perhaps it also expresses frustration at the team's most recent season.
The Oakland White Fangs -- for the book by Jack London.
The Tennessee Williamses -- for the playwright, taking the place of the Tennessee Titans.
The Washington Irvings -- for the novelist, taking the place of the Redskins. Mascot idea: a headless horseman.
Join in with Studio 360's renaming project by tweeting with the hashtag #NFLrenamed.
As for L.A., well, it would be easier to come up with a literary name for our NFL team if we had one.
200 Years of Jane Austen's Pride and Prejudice
What's happening to CalArts' literary journal Black Clock?
Score another one for the ladies: Amy Poehler memoir on the way


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|Example of a form in Slideshare
Now that they're in Eloqua, these leads can be sent a follow up email, entered into a nurturing campaign, scored and/or sent to sales for follow up. This post assumes that you have set up a Pro Slideshare account.
Integrating Eloqua with Slideshare - Step by Step
- To get started, you'll need an Eloqua user account that is API enabled. This is very easy to do, see the post on Cloud Connector Installation instructions and follow the first step only.
- The Slideshare Cloud Connector we'll be looking at here is available on our repository of interesting connectors: cloudconnectors.eloqua.com. They are free to use, just create an account and login. Please note: This account is different from your normal Eloqua login. Under Products > Feeder, select the Slideshare Lead Query option.
- Enter in your credentials: In the first step, enter in your Eloqua login credentials and keep going
- Configuration: Enter in your Slideshare username and password, the Slideshare CampaignID (it's the number at the end of the URL. For example: http://www.slideshare.net/business/lead_campaigns/12928) and the Eloqua Contact Group / Shared List that you want to add the contacts to (you'll want to pop into Eloqua and create a Contact Group / Shared List).
- Field Mappings. Map the fields from your Slideshare form to Eloqua fields. You may want to create some new Eloqua fields that you can pass the Slideshare Campaign ID to. Make sure you click on Save Settings.
- Test it. Fill out the form on Slideshare and then in the Run Step tab, click on "Full Run". Run a few tests to see if it's working. When you're happy with the results, just go to the Credentials tab to click "Enable Step" to enable it to run automatically. That's it!
You can also go into Eloqua and see if a contact has been added to the Contact Group / Shared List. To pass these contacts to your CRM, you can add this Contact Group / Shared List as a feeder into your CRM integration program. You can also create a Program or a Campaign and feed in these contacts to a nurturing program - the sky is the limit.


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A new SuperPAC backing Gov. Rick Perry's bid for the Republican presidential nomination made plans to spend as much as $55 million, an official of the pro-Perry "Make Us Great Again" said this afternoon.
Early internal planning documents from Make Us Great Again, first obtained by NBC News, highlight the fundamental role that SuperPACs will play in the 2012 presidential election following a 2010 Supreme Court ruling allowing unlimited expenditures by independent political action committees supporting candidates.
Candidates' campaigns cannot legally coordinate with or delegate tasks to SuperPACs allied with them. But several of these organizations are run by their former employees and others with whom they have close ties.
Perry's former chief of staff, Mike Toomey, co-founded Make Us Great Again in late July, nearly a month before the Texas governor officially entered the race. Toomey, also one of Texas' top lobbyists, served under Perry from 2002 until 2004.
The pro-Mitt Romney super PAC, "Restore Our Future," was founded by the campaign attorney for Romney's 2008 presidential nomination bid, Charles Spies.
"Make Us Great Again" spokesman Jason Miller, said the document is an outdated estimate of how much the group plans to spend, but he could not provide an updated figure Tuesday.
"I can confirm that [the figure] did come from us," Miller said. "I wouldn't expect a new estimate soon, but I'd stay tuned."
Miller said the document was authentic, but he did not give it to NBC News.
NBC News reported that Make Us Great Again plans to kick off spending with a $5 million advertising campaign on TV stations in Iowa and on the national-reaching Fox News. The internal document said the super PAC would spend all but $10 million of the total $55 million by March 25, 2012.


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John McAfee's ability to evade capture during his peculiar three week hide and seek with the Belize authorities could have a simple explanation – he has been 'hiding' in neighbouring Guatemala all along.
In a new post on his whoismcafee.com blog, the now world-famous antivirus pioneer reveals that he has left the country after using an earlier report of his arrest as part of an elaborate ruse to deceive police.
According to McAfee, the individual who crossed the Mexican border last Friday was in fact a body double carrying a North Korean passport in his name.
The real McAfee was safe and well and now accompanied by a woman called Sam and two journalists from Vice Magazine, he said, which is where the story has since acquired yet another tangle.
A digital photograph published to accompany Vice Magazine's interview with McAfee turned out to contain embedded GPS latitude and longitude metadata that suggested it had been taken in Guatemala.
The photograph and interview apparently date to 3 December, but might McAfee have been hiding outside Belize for some time? This would explain the inability of anyone to find him in what is a small country.
In the event, after the photograph's location was made public, McAfee added a new entry to his blog claiming that the apparent mistake was also part of his grand and increasingly labyrinthine deception plan.
"I openly apologize to Vice Magazine for manipulating their recently published photo," announced McAfee.
"I, for my own safety, manipulated the xif data on the image taken from my cellphone, and created a fake emrgency [sic] so that the urgency of movement led, as I knew it would, to the hasty posting on their website. I felt that our tenuous situation demanded action, and that was the action that I chose."
So, depending on what you choose to believe, McAfee is hiding in another country and is bluffing or is really still inside Belize and the interview is a double bluff.
Or perhaps he is neither of these locations and is toying with his growing audience as part of a bizarre publicity campaign with obscure motives.
Officially, McAfee is wanted for questioning as a 'person of interest' in the murder three weeks ago of his neighbour, Gregory Viant Faull. It's never been clear whether McAfee is really a suspect but the former antivirus 'king' has said he would not hang around to find out. He believes the Belize authorities want to do him harm.
Update: McAfee's blog has since announced that he is in Guatemala and has plans to hold a press conference.
"I am in Guatemala and will be meeting with Guatemalan officials this morning. If all goes well I will do a press conference tomorrow [5 December]," he said.


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Los Angeles, California - Seeking a BC/BE Psychiatrist. Full-time position. Competitive compensation; comprehensive benefits. One to two years of experience preferred, but new graduates are welcome to apply. This position is a mix of inpatient and outpatient services with responsibilities including providing assessment, consultation and direct clinical care in a 24 bed inpatient unit and in the outpatient ambulatory primary care setting. The behavioral health campus encompasses the inpatient unit, a 25 bed chemical dependency unit and a new state of the art crisis stabilization unit (psychiatric emergency room) for 23 hour stays. Join a well-established, interdisciplinary team at Providence Medical Associates' Psychiatric Services outpatient clinic on the Providence Little Company of Mary campus, a behavioral health center of excellence. Leadership opportunity exists if desired. Enjoy a healthy work / life balance in sunny southern California. Please note: * No visa sponsorships * Must have CA license or have application in process * Must be board-certified or -qualified (within five years of obtaining eligibility) * Strongly prefer local candidates If this sounds like a fit, please send your CV and we will be in touch with more information. Thank you.
Where You'll Work
Providence Medical Associates is a multi-specialty medical group of approximately 200 physicians including ambulatory practices, a hospitalist and post-acute team, and several urgent care centers. Our team provides convenient, personalized care serving the South Bay, mid-Los Angeles, San Fernando and Santa Clarita Valley communities. We are affiliated with Providence Health & Services and our ambulatory sites are near Providence hospitals in the South Bay (Providence Little Company of Mary Medical Center Torrance, and Providence Little Company of Mary Medical Center San Pedro) and the Valley (Providence Saint Joseph Medical Center in Burbank, Providence Tarzana Medical Center and Providence Holy Cross Medical Center in Mission Hills).
Where You'll Live
The South Bay of Los Angeles offers a wonderful quality of life, with family friendly neighborhoods, easy access to great parks, golf courses and beaches, and a colorful population that makes the area one of the most ethnically diverse in the nation. Some of California's most famous beach communities are found in South Bay, including Manhattan Beach and Palos Verdos. Providence operates clinics throughout the region, as well as major hospitals in San Pedro and Torrance.
Who You'll Work For
Providence Health & Services (PH&S) is a not-for-profit system of 34 hospitals, more than 600 clinics and hundreds of locally driven programs across five western states: Alaska, California, Montana, Oregon and Washington. Providence is committed to improving the health of the communities it serves, with a special emphasis on its mission to serve the poor and vulnerable. PH&S is a partner organization of the Providence St. Joseph Health family.
Job ID Number: 8269
Facility Name: Providence Medical Associates
Location Name: South Bay of Los Angeles, CA
Brand Name: Providence Health & Services - CA
Provider Profession: Physician/Surgeon
Medical Specialty: Psychiatry
Job Setting: Medical Clinic
Type of Role: Clinical
Email: firstname.lastname@example.com
Phone Number: 503.203.0858
Schedule: Full Time
CP: Yes
CB: Yes
NP: No
PA: No
HC: Yes
IS: No
YM: Yes
Let's Talk!
You've got questions? I've got answers! Reach out today, and together, we'll find a job that checks all your boxes.
Express Interest
Dirk Foley
Provider Recruiter


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Style Files - Neutrals
27 comments:
lovely links and lovely looks, i love neutrals especially with nice accessories! Have a great weekend Anna xoxoReplyDelete
i so wish i was wearing any of these outfits right now... :)ReplyDelete
I love that top photo, with the bit of color peeking out from the sleeves. Perfect! Great inspiration!!ReplyDelete
Anna that first outfit is GORG! Love the pop of color so classy!ReplyDelete
i love that skirt (or dress) in the first photo!xoxo jcd http://cornflakedreams.blogspot.com/ReplyDelete
though im a fan of color, i'm a fan of neutrals too! so sophisticated!ReplyDelete
and make your own girl scout cookies? are you kidding me!! im in love - *running* to that link now!
That pop of colour is just perfect. Have a great weekend, Anna!ReplyDelete
So pretty - I am lovin the neutrals right now tooo! I'm off to check out all of your links!! :) xoReplyDelete
I think that girl in the second photo is so cute! I love her outfit :)ReplyDelete
I love that first outfit. The pop of colour is fantastic!ReplyDelete
I love a good scarf too... I think they can totally make or break an outfit. Happy Friday!ReplyDelete
Hug from Holland,
Great looks! Hope your weekend is a good one.ReplyDelete
PS. I love olive & a too. Heather is so sweet!
loving that pop of pink in the neutral outfit.ReplyDelete
I just bought some nude pumps and I'm in love :)ReplyDelete
I love neutrals with a punch of colour!ReplyDelete
Have a great weekend!
hellooo...i love that first outfit. hot pink + neutrals = win!ReplyDelete
LOVE neutrals...awesome inspiration, for sure!ReplyDelete
love that first shot....i love layering, i do it mostly in the fall :)))))))ReplyDelete
Your blog is incredible....I love that first outfit so much! xxx to you- Emily from EL VintageReplyDelete
PS- putting your blog on my blog list...must read daily! :-)xReplyDelete
love these outfits, have a great weekend!ReplyDelete
some days i feel like neutrals, but today i'm feeling like hot pink!ReplyDelete
you are always so sweet to comment on my blog. i appreciate the love....and happy weekend to you too!
amateur couture
love the neutrals. love.ReplyDelete
i just took a big sigh of ahhhhh. i love neutrals. im a neutrals gal through and through. lovely. happy weekend, anna!ReplyDelete
I'm obsessed with that first photo - definitely a look I want to recreate this spring!ReplyDelete
I am such a neutral palette addict, and love the pop of color one the first pic.ReplyDelete
great weekend links!
I'm a huge fan of neutrals. It's always what I fall back on when I can't think of anything to wear. The first photo is so pretty and so is that coat!ReplyDelete


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As you know, I'm obsessed with figuring out the future of digital media. And to do that, there's nothing better than putting stakes in the ground – based on the best available information and sharpest analysis I can muster – and then checking back to see how they held up.
In the last couple of weeks, two of the calls I made have come true; and that offers us a great opportunity to re-visit them, and see what we can learn from them.
Hulu Plus: Great Experiences Worth Paying For
First, Hulu Plus, which is thriving with over 1 million consumer subscriptions.
A year ago, when success seemed far from likely, I went out on a limb and estimated that Hulu Plus would have huge traction with consumers, surpassing $100 million in revenue in 2011. As it turns out, Hulu's growth with its subscription product has been even faster than I expected – albeit with lower revenue per customer, given to CEO Jason Kilar's smartly aggressive pricing, and the resulting much higher consumer adoption. The result has been substantial corporate revenues that have helped make Hulu market itself, enticing suitors to break it free of its complicated parent-company structure.
Content licensing agreements may still represent the greatest complexity of Hulu's business under any ownership scenario, but what's been a fascinating expectation exceeder is that by delivering the most desirable content and consumer experience, Hulu has gotten consumers to open their wallets in droves. That's something that we can all learn from.
PayPal Acquires Zong: Making Payments Easier
And second, EBay's PayPal, which recently bought mobile payment company Zong for $240 million.
Back in June 2010, I strongly recommended this deal and pointed out its many advantages. Indeed, Zong's payment system makes it easy for consumers to pay – leveraging the addictive relationships people have with their mobile phones.
As my newsletter readers know, I recently updated my formula for consumer spending on digital media.
The Consumer Media Spending Formula:
(Desire + Relationship + Ease) X Scarcity = Spend
Now both of these transactions are reinforcing it for me.
The Future of Consumer Paid Media
Beyond that, these two announcements also tell us something important about the rapidly approaching future of digital media: increasingly, the industry will be relying on consumers to contribute toward its profitability.
Now it's up to us to create great content and meaningful experiences that are worthy.
A Bonus Prediction: Apple Versus Facebook in 2012
And that's why I'll take this opportunity to make a bonus prediction.
By this time next year, we will be in the early stages of what will later become an all-out war over who will be the master payment and currency provider for digital media. Even as Paypal has made significant upgrades with the Zong acquisition, they won't be enough to ignite Paypal as the leader in the key venues: on the social networks and in mobile applications. Instead, this online conflagration will, I believe, be waged primarily between Apple and Facebook Credits.
What do you think? And what's your favorite digital media prediction for 2012?


text: I was quite surprised to find out that BProc lives at: http://bproc.sourceforge.net and is active and maintained and has docs and maillist etc. On the other hand, assumption that Scyld website will be the first place which will point me to BProc news was quite false. BProc seemes to be mostly one-man-show by Erik Arjan Hendriks and he is not working for Scyld anymore and might not be on good terms with Scyld management. Sorry to touch these personal things but I think they have large technical implications and therefore should be known to cluster developers. BProc is GPL project and is used by several independent groups now. Good. Please help me to make the picture clear by completing the list. So far I know these projects using BProc: 1) Scyld Beowulf, of course http://www.scyld.com 2) LANL Clustermatic (where Erik's most recent email is) http://www.clustermatic.org/ 3) Clubmask and Maui http://clubmask.sourceforge.net/ http://www.supercluster.org/maui/body.html If you know others, please let me know. My apologies to anybody offended by this message, especially to Scyld and Erik Hendriks. Please correct any false statements I made - Internet was my only information source. The picture I made from various small pieces was quite big surprise for me, so I had to post this. (Sorry for this non-technical entry on bproc-users, I hope I'll be less off-topic next time.) Best Regards Vaclav Hanzl


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Biological Sciences
Research Highlights
May 2005
A fluorescent probe finds a second use in a resin for protein pull-downs
With the ready availability of genomic information, the focus of biology is shifting toward the study of protein complexes and protein-protein interactions. Researchers at Pacific Northwest National Laboratory (PNNL) have shown that FlAsH, a Fluorescein Arsenical Helix binder, can be used to find a protein's binding partners (1). This probe was previously used to label genetically tagged proteins in vivo, allowing monitoring of the protein's location within the cell (2,3), and it permits structural analysis and validation of isolated complexes (4,5). Advantages are that 1) the same protein has to then be genetically modified only once for several very different purposes, and 2) researchers do not have to perform the laborious purification process to raise antibodies for protein pull-downs or imaging experiments.
Requirements for the perfect protein tag/affinity reagent system are 1) a small genetic tag size, 2) an uncharged tag, 3) tight tag/probe binding with minimal background interactions, and 4) a mild elution methodology orthogonal to the wash methods. The FlAsH approach fulfills all of these requirements. The protein of interest is tagged genetically with a tetracysteine motif, which allows it to bind to the FlAsH resin. The protein complex can then be released in a mild, non-denaturing, one-step procedure with a competing dithiol. The small tag size enables ease of cloning, as the genetic tag can be added directly on the primers and thus be incorporated easily into either terminus of any protein expressed in an organism of choice. The PNNL team chose the bacterial RNA polymerase (Rpo) from Shewanella oneidensis as the first model system, with the alpha subunit as bait. The core enzyme is a stable complex of two alpha (A) subunits, the beta (B) subunit, and the beta prime (C) subunit.
PNNL researchers synthesized a new FlAsH resin with a longer linker on a glass support. For the pull-down, the tetracysteine-tagged RNA polymerase A subunit was overexpressed in S. oneidensis, and the lysed cells were exposed to the affinity resin. After washing, the complex was eluted, and the eluted protein was run on sodium dodecyl-sulfate polyacrylamide gel electrophoresis (SDS-PAGE). As shown in Figure 1A, the main protein bands above background are the correct sizes for RpoA (36 kDa), RpoB (150 kDa), and RpoC (155 kDa). Protein identity was further verified by capillary liquid chromatograph-tandem mass spectrometry with methods established at PNNL. Analysis using conservative filters gave good sequence coverage for the core enzyme in the bait experiments (Figure 1B) with no background for the target proteins RpoB and RpoC and a low background for RpoA.
This work is published in the inaugural issue of Molecular Biosystems, a new journal directed at research on the interface of chemistry and systems biology. It is sponsored by the U.S. Department of Energy's Genomics: Genomes to Life program through DOE's Office of Science. PNNL team members are M. Uljana Mayer, Liang Shi, and Thomas C. Squier. The researchers, joined by Baowei Chen, Haishi Cao, Ping Yan, Seema Verma and Yijia Xiong, are currently refining the tags and probes and extending the range of applications.
Figure 1. A) SDS-PAGE gel of combined elutions: 1) lysate only and 2) 4Cys-RpoA bait; B) Schematic showing sequence coverage for the holoenzyme subunits (3 runs): top bar 4Cys-RpoA bait, bottom bar control. Red: one or two peptides; yellow: 3 to 5 peptides; green: 6 to 9 peptides; blue: 10+ peptides. Full Image
- Mayer MU, L Shi, and TC Squier. 2005. "One-Step, Non-Denaturing Isolation of an RNA Polymerase Enzyme Complex using an Improved Multi-Use Affinity Probe Resin." Molecular BioSystems 1(1):53-56. DOI:10.1039/b500950b.
- Griffin BA, SR Adams, and RY Tsien. 1998. "Specific Covalent Labeling of Recombinant Protein Molecules Inside Live Cells." Science 281(5374):269-272. DOI:10.1126/science.281.5374.269.
- Gaietta G, TJ Deerinck, SR Adams, J Bouwer, O Tour, DW Laird, GE Sosinsky, RY Tsien, and MH Ellisman. 2002. "Multicolor and Electron Microscopic Imaging of Connexin Trafficking." Science 296(5567):503-507. DOI:10.1126/science.1068793.
- Chen B, MU Mayer, and TC Squier. 2005. "Structural Uncoupling Between Opposing Domains of Oxidized Calmodulin Underlies Enhanced Binding Affinity and Inhibition of the Plasma Membrane Ca-ATPase." Biochemistry 44(12):4737-4747. DOI:10.1021/bi0474113.
- Chen B, MU Mayer, LM Markillie, DL Stenoien, and TC Squier. 2005. "Dynamic Motion of Helix A in the Amino-Terminal Domain of Calmodulin is Stabilized upon Calcium Activation." Biochemistry 44(3):905-914. DOI:10.1021/bi048332u.


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Deskjet Printer Install and Setup:
Drag your printer from its package and get your power cords ready to fix it to your printer. Fix your power cord to the rear of your printer. Connect the other end of the power cord to the external power source. Once the connection process is over. Power up your printer setup. Press and Hold the Home button to Turn ON your HP Deskjet 3655 printer setup. The HP printer driver can be downloaded from 123.hp.com/dj3655
How To Fix Your Printer?
- You could find the home screen on your printer.
- By using the arrow keys on your control panel, enter the credentials.
- Credentials are required to initialize your printer.
- Then insert your printer cartridges.
- Open the ink cartridge door using the the cutouts on the sides of your printer.
- Now install the ink cartridges according to the respective colors.
- Once you install, close the access doors.
- Load stack of paper in the input tray, Print an alignment page.
- Once your alignment page is printed scan it by placing the document on your scanner glass.
- Now scan the document, while you do so a message box appears with "alignment successful" message pops up.
- Until you complete all these initializations the printer, make sure you dont connect your printer to a wireless network.
This is how you need to do the basic initialization. Once you have finished you can install the printer setup to your computer or any of your personal devices. To install the software you can download the file from 123.hp.com/setup. Now install the setup to your device. You can also make use of the CD Disc, insert the disc and follow the on-screen instructions to complete the setup.


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Long-term use of osteoporosis drugs seems to change bones in a way that could lead to unusual leg fractures, according to two reports presented earlier this month at a meeting of orthopedic surgeons. Doctors have reported seeing the unusual fractures in some patients on bisphosphonate drugs such as Fosamax.
It seems paradoxical that a medicine designed to protect against bone fractures in fact might be the cause of broken legs. Adding to the confusion, the U.S. Food and Drug Administration released a statement in the same week as the medical conference that said there is no clear connection, based on available evidence, between the bisphosphonates — including Actonel, Boniva and Reclast in addition to Fosamax — and atypical femur fractures.
The unusual bone breaks — called atypical subtrochanteric femur fractures — were first documented in small clinical reports and through the FDA's MedWatch system, which monitors side effects of drugs after they've been approved. Such reports do not necessarily mean the drug is the cause of the problem, but multiple reports of the same side effect with the same drug can spur additional investigation. Other potential side effects of bisphosphonate drugs have been identified through the FDA's reporting system, including serious jaw deterioration and esophageal cancer.
Here's a closer look at what's known about the safety and effectiveness of bisphosphonates.
What is osteoporosis?
Osteoporosis is a weakening of bones that results from bone loss occurring with age or because of disease. People with osteoporosis can suffer pain, lose inches from their height and are at high risk of fractures in their wrists, hips and vertebrae. Ten million Americans, men and women, have osteoporosis, and the disease causes about 1.5 million fractures every year, according to the National Institute of Arthritis and Musculoskeletal and Skin Diseases.
Doctors use bone density measurements to diagnose the condition, and recommend screening in women over age 65 and men over age 70. Earlier screening should be done in people with certain risk factors, such as those with a family history of osteoporosis or who have broken a bone after age 50; women who went through early menopause or recently stopped hormone therapy; and people taking medications such as prednisone, aromatase inhibitors or anti-seizure drugs.
How do bisphosphonates work?
Normal healthy bone is constantly being renewed through a cycle of dismantling and replacement of bone cells and minerals. Bisphosphonates get incorporated into newly formed bone in place of naturally occurring phosphate, along with calcium. They inhibit the breakdown of bone, thereby favoring the building-up side of the cycle.
The bisphosphonates are extremely effective at reducing the bone loss that occurs in osteoporosis. Clinical trials have shown that drugs such as Fosamax reduce the risk of fractures by 30% to 50% in people with osteoporosis, according to Dr. Daniel Solomon, a professor of medicine at Harvard Medical School, who studies the drugs.
How might bisphosphonates make bones brittle?
Since the drugs interfere with normal bone turnover, it's not hard to imagine that bisphosphonate drugs may affect bone structure.
The atypical fractures in people taking Fosamax — the first of the drug class to be approved, in 1995 — now being noticed by orthopedic surgeons across the country are happening in the thigh bone below the hip rather than within the joint, which is the more normal pattern seen for bones with osteoporosis. And they're straight across the bone, unlike most osteoporotic breaks. They occur among people who have been taking the drug for five years or more.
The reports at the meeting of the American Academy of Orthopaedic Surgeons were detailed studies of bone structure in osteoporosis, in which bones of patients taking bisphosphonates were compared with those of patients receiving other osteoporosis treatments. In one of the reports, a research team led by Dr. Joseph Lane at New York's Hospital for Special Surgery did bone biopsies and found qualitative differences in bone that might explain the atypical fractures. A second study, by a group at New York Presbyterian Hospital, used sophisticated bone density scans and found that bisphosphonate drugs initially increased structural integrity of the femur but that the effect tapered off over four years of treatment.
What's the risk for people taking the drugs?
Although the new studies describe possible ways that the drugs could cause atypical leg breaks, they cannot say how often this might happen or who is at risk. Solomon says the best evidence to date is a 2009 study published in the Journal of Bone and Mineral Research — the same paper, as it happens, on which the FDA based its announcement that not enough evidence exists to make a connection. Using medical records from nearly 12,000 patients in a Danish registry, it found similarly low rates of atypical fractures in patients taking bisphosphonates and patients not taking the drugs.
"We know these drugs reduce the risk of fracture," Solomon says — over a time span of three years, which was how long the clinical trials that proved the drugs' effectiveness ran. But, he adds, "we don't really know their risk-benefit ratio after five years."
To better address the question, scientists would need to conduct a large-scale study following tens of thousands of patients for at least five years — a very expensive and unlikely prospect.
Current estimates put the rate of atypical fractures at fewer than 1 in 10,000 patients who take bisphosphonates, according to the American Society for Bone and Mineral Research, a specialist group of scientists and doctors. (The group has assembled a task force to study the issue in detail and will present its findings in October.) "That's a very small number compared to the people on the drug who have benefited from its fracture protection," says Dr. John Adams, who directs UCLA's Orthopaedic Hospital Research Center, a number that is likely in the tens of millions.
But Lane says the types of fractures he's seen in patients are truly different from others. And though published studies are sparse, when he asked a conference room full of orthopedic surgeons how many had seen one of these atypical fractures, more than half the doctors raised their hands, he says. And this, he adds, is something new. "Twenty years ago, we never saw this kind of fracture. Maybe the drug forces you to get this kind of fracture instead of the more traditional … fractures." He thinks that interrupting drug treatment for a period of time — putting patients on what's called a "drug holiday" — might be the answer, noting that he and others at his hospital do just that.
How about those other scary-sounding side effects?
As with atypical fractures, other serious conditions have occurred in people taking bisphosphonates. Studies support an association between the drugs and osteonecrosis of the jaw, a bone-killing infection often triggered by dental work. The condition is rare — rates of osteonecrosis of the jaw have been estimated at between 1 in 10,000 and 1 in 100,000 — although Solomon, for one, thinks the rate may be significantly higher than that. In addition, the risks of these side effects can be minimized by taking some precautions, such as getting dental work done before starting on bisphosphonate therapy.
Closer investigation has not found any evidence for a connection between the bisphosphonates and atrial fibrillation (an abnormal heart rhythm that causes poor blood flow through the body), according to the FDA. The jury is still out on esophageal cancer, a condition so rare it may be impossible to establish a link to the drugs — only 23 cases of esophageal cancer in patients on Fosamax, the bisphosphonate that has been on the market longest, were reported in the U.S. over a decade.
In spite of the known or suspected risks, doctors say the benefits of bisphosphonate drugs — reducing fractures in people with osteoporosis — far outweigh the low risk of the potential adverse events. "Unequivocally, these are wonderful drugs," Lane says.


text:
Sir Paul Smith has created an exclusive collection of clothes for MR PORTER. The tightly edited range consists of nine styles and is, according to Sir Paul, "Ivy inspired". Specifically, it's inspired by Take Ivy, a book of photographs shot on US Ivy League campuses in the 1960s and originally published in Japan in 1965. "I've always liked Ivy style," says Sir Paul. "It's a good timeless look and I've just given it the Paul Smith twist. So the blazer is quite short, which is of now, where previously it would have been longer."
Sir Paul, London, May 2009
Sir Paul, who has been at the forefront of British fashion for five decades, is well placed to explain how Ivy style first came to the UK from the US. "In London the Ivy look was brought in by a lot of the GIs who were stationed out in places such as Cambridgeshire. They came into London at the weekends and went to clubs such as The Scene, in Soho. There was quite an interest in the way these guys dressed, because they looked so cool and slick." In Sir Paul's opinion, "The clothes are quite timeless, and there's always been a hard core of fans." That classic appeal brings a practical advantage: "It's a look you can easily wear with your existing wardrobe," he says.
As Ivy League style spread from US campuses - as illustrated in this shot from Take Ivy - its hip practicality gained the attention of young British men
For the designer, the Kennedy clan - "all of them" - are the icons of the Ivy look. "There are lovely pictures of Jack wearing Converse All-Stars, regular trousers and a pale-coloured sweater with patch elbows. It's the whole Hamptons look." However, Sir Paul's other source of Ivy inspiration comes from the music scene. "For me it was very much about the jazz era; Blue Note [a US jazz label] album covers always had these very cool-looking guys, with a very sharp look," he remembers. "Herbie Hancock and John Coltrane were the guys who stood out as being very well dressed."
The exclusive Paul Smith collection for MR PORTER will be available in the US from 8 May


text:
By Jon Matonis
American Banker
Wednesday, February 27, 2013
Last weekend at the Free State Project's annual Liberty Forum
in New Hampshire, entrepreneurs Zach Harvey and Matt Whitlock advanced
the anonymous purchasing of bitcoin with their new Bitcoin ATM. The little machine, about 24"H x 12"W x 12"D, exchanged and dispensed over $5,500 worth of bitcoin in one weekend.
to the way a vending machine operates, the orange prototype accepts
cash bills and reads a QR code containing the depositor's Bitcoin
address. After subtracting a 1% transaction fee, it delivers bitcoin to
the address in about five seconds. The Bitcoin Machine can accommodate
paper note denominations up to $100.
Previously, individuals who
wanted to purchase bitcoin privately without revealing personal details
had to arrange face-to-face meetings through LocalBitcoins.com; make use of bitcoin-otc,
an online marketplace where participants take counterparty risk and
rely on user reputations measured by an e-Bay-like ratings system; or
make a cash deposit at a bank or retail location, under the watchful eye of security cameras.
with a device that directly converts paper cash to bitcoin anonymously,
the interaction is between human and machine. The value of that subtle
difference should not be underestimated. No longer does the buyer of
bitcoins have to show his or her face, or trust counterparties to make
good on their end of a deal. Depending on how many bills each bitcoin
ATM can hold and how much bitcoin it can digitally store, users can now
enter the bitcoin blockchain in a very significant and private way.
The New Hampshire-based startup, Lamassu Bitcoin Ventures,
hopes to commercialize the technology and get the countertop ATMs
placed in restaurants, bars and other retail businesses. Harvey told CNET's Declan McCullagh.
"If we made these machines somewhere around $1,000 to $1,500 each,
depending on the commission, they could be able to buy [the machine] and
make it back within a reasonable period of time."
This could
prove to be very profitable for the establishments hosting the machines
if their bitcoin inventory gains dollar value prior to sale.
Additionally, Lamassu Bitcoin Ventures could be the exclusive provider
of bitcoin for the ATMs or partner with an existing exchange to provide
greater risk management.
Even people who have been in the Bitcoin
world for a while and have used every type of exchange are blown away by
the simplicity of this machine," Harvey said. "I'm just putting in a
dollar. Before they really know what's going on, their phone tells them,
'You have Bitcoin.'"
Despite media reports claiming this to be the world's first Bitcoin ATM, that notable distinction belongs to Todd Bethall of BitcoinATM.com, which dispenses plastic BitBills and sends bitcoin to a Bitcoin address.
in 2011, Bethall's beta ATM comes equipped with a Genmega GK1000 Kiosk
running Windows XP Pro with ActiveX drivers for the bill acceptor,
printer and card reader. The California corporation that owns the
original Bitcoin ATM was recently put up for for sale
at the price of 1,500 bitcoin, but that was before bitcoin's recent
price appreciation. At the current exchange levels, the asking price now
works out to about $45,000.
Monday, March 4, 2013
Tabletop Bitcoin ATM Is Huge for Payment Privacy
Posted by Jon Matonis at 3:33 PM
Labels: anonymous, bitcoin, digital bearer instrument, privacy
1 comment:
Subscribe to: Post Comments (Atom)


text:
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|2008-10-25, 11:32
|Link #1
♪~ Daydreaming ~♪
Graphic Designer
Join Date: Dec 2005
Location: Italy
Kannagi - Character Discussion - Jin Mikuriya
The purpose of this thread is to provide a place to discuss all things Jin Mikuriya related.
To keep the discussion enjoyable for all Kannagi fans, please follow the guidelines below and stay on-topic!
Note: Please don't use this for the specifics (i.e. episode, chapter, game, etc. discussion) there are other threads for that stuff.Thread Guidelines
|2008-10-27, 20:00
|Link #4
Senior Member
Join Date: May 2007
no love for Jin?
I wonder why this guy is so lucky to have three girls around him and he doesnt seem interested in any of them, which makes matters worse
After watching the opening sequence for the nth time, and noticing that all characters have a mini role within the idol story, I found it strange that Jin was missing, or not exactly missing. He was always thereto be more precise, as Nagis manager. It makes sense now... but geez how the heck did I miss it?
Following the logic that he prefers big oranges, its sort of weird that he doesnt seem to be interested in Tsugumi at all, given that she is his childhood friend, and thus lives very close to him (and dont forget that she has just the right size as well). I have no doubts that he is a pervert, or a bit too self-conscious of his own situation, with special regards to Nagi and Zange-chanbut he lacks the same "kind of perversion" with Tsugumi. Is it because they have known each other for too long? or that he really doesn't have anything going on for her... Hopefully that conversation he had with Zange would make sense later on... or at least explained in full details...
|2008-10-27, 20:38
|Link #5
Seishu's Ace
Join Date: Dec 2005
Location: Kobe, Japan
As for Tsugumi, I just don't think Jin has reached a level of emotional sophistication yet where he can separate his feelings of friendship from possible romantic ones. That sort of lets her out as an object of affection, for now. Clearly he's aware of the opposite sex in the physical sense, but he doesn't seem to have much of a clue what to do about it.
|2008-10-27, 20:46
|Link #6
Obey the Darkly Cute ...
Join Date: Dec 2005
Location: On the whole, I'd rather be in Kyoto ...
Age: 61
He does mention to Zange that he has some unresolved matter with his childhood friend but it'd be better if he just said it to her directly....
... but I'd be lying if I said I had any idea which way THAT foreshadowing flies.
|2008-10-28, 02:21
|Link #7
Join Date: Mar 2008
|2008-10-28, 03:42
|Link #9
Senior Member
Join Date: Jun 2007
and there's one chapter in the manga where they're...
|2008-10-28, 03:53
|Link #10
Senior Member
Join Date: Jan 2007
Here are some of my observation and thoughts about Jin and how rapidly his character has changed in just 4 episodes:
Episode One:
+Jin getting aroused by staring at Nagi's ass.
+Jin trying to grope Nagi when she was half asleep.
+Jin getting aroused by staring at Nagi's pantsu and offered to wash it for her.
Typical male harem like-character personality traits.
Episode Two:
-Jin is suprisingly a different person in this episode; as in a bit more mature and in control of his senses and feelings. Actually I might've think that Jin has completely given up on having any romantic relationship with Nagi at some point in this episode, period. As he no longer shows any type of affection in this episode at all and the later episodes to come.
-Jin's male harem-like behavior vanished in just one episode, amazing!
-Jin didn't show any type of affection toward Nagi at all.
-Jin didn't show any type of affection toward Tsugumi either.
Notable scenes in this episodes were:
+Nagi's pantsu he was holding without showing any embarassing thoughts.
+Jin giving Nagi a piggyback on their way back home. Especially the way he was carrying her. His hands were getting a very good "grasp" on her tights, yet he didn't think much about what his hand is feeling at all.
Episode Three:
-Jin much like episode two, pretty much very in control of his senses and feelings for the opposite gender around him.
-Jin dodged Nagi's HUG ! 'nuff said.
Only notable scene are:
+Jin accidently almost saw Nagi's pantsu under the table.*
*Special note: This scene is a bit different from how it happened in the manga.
+Jin being cautious about his oppai perference around Tsugumi.
Still no sign of who Jin may be interested in...
Episode Four:
-At this point, it seems Jin is treating Nagi almost as if she is his real imouto. Just their interaction with each other is evident enough in this episode and from the previous episodes.
Only notable scene are:
+Jin getting a lick on the cheek by Zange.
+Jin's ecchi thoughts 'bout Zange.
What we know is:
~Tsugumi openly likes Jin. As in she's aware of it, but haven't shown her feelings for him yet.
~We also know Hakua appears to have some type of crush for Jin as well, but what we don't know is why and how that crush on him was developed from, yet.
Zange and Nagi are pretty much in netural terms with Jin, more so with Nagi than Zange. As Zange most likely have a different type of agenda for wanting Jin.
That's what I've gathered for now, might add more if anything else pop up.
|2008-10-28, 23:58
|Link #12
Senior Member
Join Date: Dec 2006
Location: Galactic Fairy Fanclub
Supporter of sisterly love supports TsugumiXJin as well.
|2008-10-29, 00:12
|Link #13
Obey the Darkly Cute ...
Join Date: Dec 2005
Location: On the whole, I'd rather be in Kyoto ...
Age: 61
Aye, Jin solves Nagi's and Zange's problems, they go back to their deity duties, and Jin will couple up with Tsugumi .... thats my speculative prediction if we get an ending. My cynic bet is on a non-ending 'reset'. Anything else would be quite unusual for a story.... though welcomed over a non-ending.
Don't see how they could explore some of the complexities of the manga within the short time budget they have in the anime.
|2008-10-29, 00:40
|Link #14
Senior Member
Join Date: Dec 2006
Location: Galactic Fairy Fanclub
Anna, Hakua and Nagi needless to say are must-be-there members; the club president and Tsugumi (if she gets tired of Jin) are also welcome.
Thinking if good to be JinXDaitetsu. Boys' love, anyone?
|2008-11-01, 12:25
|Link #15
Senior Member
Join Date: Mar 2008
Location: So Cal
Just because Jin showed attraction to Nagi in episode one doesn't necessarily mean he was developing romantic feelings for her. And it would be hard to find a guy who's not a little turned on from a hot nun licking their face. Heh.
On the other hand, until Jin starts showing some physical attraction to Tsugumi, their relationship is not gonna go anywhere.
|2008-11-04, 19:05
|Link #18
Son of God
Join Date: Aug 2006
The sticking plaster thing is an annoying motif that keeps cropping up recenty, especially on the nose. I first noticed it in Moyashimon where it randomly appeared and disappeared in place of Aoi Mutou's nose, I presume it's some idiom like the sweatdrop thing.
As for who Jin will end up with, my money is on Hakua - she fancies him and he clearly liked her body, so if Nagi gets Zange out of there and they go back to being sacred trees then it would be a neat ending. Maybe she could do a Hotaru and expel Zange from herself?
|2008-11-04, 20:44
|Link #20
Join Date: Mar 2008
Location: CH aka Chocaholic Heaven
Age: 35
For the plaster, after re-reading the manga I noticed it was used for a pun at the end of chapter 1:
|Thread Tools


text:
|Albumin is a protein that circulates in the blood. By testing levels of Albumin, your doctor can determine whether your kidneys and liver are functioning properly.
|Alternate-day Treatment
|Treatment where the medication is given every other day, with no medication on alternate days. Some doctors like to give prednisone in this fashion.
|A drug that relieves pain.
|When your body doesn't have the normal amount of red blood cells, you have anemia. It can be caused by very many things, including lupus.
|Specific proteins made by your body's white blood cells. They are for defense of the body against foreign enemies. In certain diseases such as lupus, they attack the patients body.
|Anticardiolipin antibody
|A type of antibody in the antiphospholipid antibody family.
|Anti-DNA (also Anti-dsDNA)
|Antibodies to DNA. Between one-half and 75 percent of the patients with SLE have or will have this antibody. It can indicate activity of the disease. Although there is no "one test" that confirms lupus, the diagnosis is nearly certain if such antibodies are present.
|The substance that triggers the formation of antibodies. In lupus it may be a foreign substance or a product of the persons own body.
|An agent designed to counteract or suppress inflammation. Nonsteroid anti-inflammatory drugs usually refer to "aspirin-like" drugs such as ibuprofen or naproxen.
|Drugs, such as Chloroquine or Hydroxychloroquine (Plaquenil), originally developed to treat Malaria that have beneficial effects in the treatment of Lupus.
|Antinuclear antibodies (ANA)
|Proteins in the blood that react with the cell nuclei. Nearly all SLE patients have this antibody. However, it can be found in healthy people and in most people with autoimmune disease.
|Antiphospholipid antibody
|Antibodies directed against substance in cell membranes. In the presence of a co-factor, can alter clotting and lead to strokes, blood clots, miscarriages and low platelet counts
|Antibody to ribonucleoprotein. Seen in SLE and patients with Mixed Connective Tissue Disease.
|This antibody is found only in lupus. The "Sm" stands for Smith– the patient whose blood was used to identify this antibody.
|Anti-SSA (or Anti-Ro)
|This antibody is associated with Sjogren's Syndrome, sun-sensitivity, neonatal lupus and congenital heart block.
|Anti-SSB (or Anti-La)
|This antibody is related to and almost always seen with Anti-Ro.
|Pain in a joint or joints.
|Inflammation of a joint or joints.
|An antibody to one's own tissues or cells.
|The reactivity of one's own immune system to one's own tissues.
|B Cell
|A B cell is a type of white blood cell (alymphocyte) that makes antibodies.
|Butterfly rash
|Red facial rash over the cheeks and the bridge of the nose. Also known as the malar rash.
|CBC (Complete Blood Count)
|A blood test that measures the amount of red blood cells, white blood cells and platelets in the body.
|Central Nervous System.
|Collagen is a protein found in cartilage, bone and skin.
|Collagen vascular disease (Connective tissue disease)
|An old term that incorporates those rheumatic diseases that are characterized by dysfunction of the immune system.
|Connective tissue
|The "glue" that holds the body together.
|A group of proteins found in the body that regulate inflammation. A low or falling levels suggest inflammation (lupus activity).
|A natural anti-inflammatory hormone made by the adrenal glands. it is now made synthetically. A common type used in lupus is prednisone.
|Synthetic or man-made corticosteroid.
|A blood test that measures kidney function
|Creatinine Clearance
|A 24-hour urine collection test to determine kidney function.
|Cutaneous lesions
|Visible changes in the skin: rashes, scarring and/or sores
|Discoid lupus
|A type of skin disease seen in SLE; it can also exist by itself.
|Female hormones produced by the ovaries.
|Fibrositis (Fibromyalgia)
|A condition that is characterized by muscular pain, weakness, sleep disorders, fatigue, and tender points on the body. Often mistaken for lupus although 20% of SLE patients have fibromyalgia
|Symptoms of the disease reappear or increase, an exacerbation.
|Another term for ANA; stands for fluorescent ANA.
|Inflammation of the glomerulus of the kidneys; seen in some SLE patients.
|Hemolytic Anemia
|Anemia caused by the destruction of red blood cells by the body's own antibodies. Also called Autoimmune Hemolytic Anemia.
|Immune Complex
|An antibody and an antigen that are bound together.
|A method that uses a fluorescent stain to detect autoantibodies.
|A medication such as Cytoxan or Imuran, that treats lupus by suppressing the immune system.
|A characteristic reaction of tissues to injury or disease resulting in swelling, redness, heat and pain.
|LE Cell
|A specific cell found in the blood specimens of most lupus patients. This test served as a diagnostic test for lupus in the past but is no longer performed since the introduction of better blood tests.
|Mixed Connective Tissue Disease (MCTD)
|MCTD refers to an overlap of several conditions, including lupus, scleroderma, an polymyositis. Most patients have antibodies to RNP.
|Inflammation of the kidneys.
|Nonsteroidal Anti-inflammatory Drugs (NSAID)
|A group of drugs, such as aspirin, ibuprofen and naproxen, used to reduce inflammation that causes pain, redness, heat and swelling.
|Pericardial Effusion
|Fluid around the sac (pericardium) of the heart.
|Inflammation of the sac (pericardium) around the heart.
|Sensitivity of the skin to ultraviolet light (sun, fluorescent lighting, plant lighting).
|Filtration of blood plasma through a machine to remove proteins that may aggravate lupus.
|Cells of the blood that are responsible for forming blood clots.
|Pleural Effusion
|Fluid collects in the sac lining (pleura) the lungs.
|Pleuritis (Pleurisy)
|Inflammation of the Pleura.
|Synthetic steroid.
|Excessive protein levels found in the urine, also called albuminuria. This is often the result of glomerulonephritis.
|Raynaud's Phenomenon
|Discoloration (red, white and blue) and sometimes pain or numbness in the hands and/or feet usually induced by cold temperature or stress.
|Rheumatic Disease
|Any one of the 150 disorders that affects the immune or musculoskeletal systems.
|Sedimentation Rate (Sed-rate)
|A non-specific test that correlates with degrees of inflammation.
|Sjogren's syndrome
|A disease characterized by dryness: dry eyes and dry mouth; the condition can occur by itself or accompany another rheumatic disease, especially rheumatoid arthiritis.
|Steroid generally refers to corticosteroids. They are not to be confused with anabolic steroids.
|Serologic Test for Syphillis; false positive tests can occur in people with lupus.
|Affecting the whole body.
|A low platelet count.
|An expression of antibody levels. A high titer of antinuclear antibodies may be seen in lupus.
|Undifferentiated Connective Tissue Disease (UCTD)
|Signs and symptoms of autoimmunity in a person who does not meet established criteria for lupus, rheumatoid arthritis, Sjogren's Syndrome or any other autoimmune disease.
|Inflammation of blood vessels.


text:
Q:My company now requires an annual health checkup to assess our weight, height, body fat and blood pressure, or we end up paying $50 more a month for health insurance. They say they won't penalize us for "bad" results, as long as we get the checkup. What do you think? -- Mike P., Ocala
A:We'll tell you what we think, but first, here's what we know. In the U.S., adults are twice as likely to have heart problems, arthritis, cancer and diabetes as those in Europe and Canada; and four to six times as likely (at the same ages) as folks in Japan, Mexico and China. It's because of tobacco use, food choices and portion sizes, physical inactivity and unmanaged stress -- all self-inflicted reasons that rates of chronic illness and health-care costs (public and private) are so much higher in the U.S. than elsewhere.
Telling employees to chip in another $600 a year for health insurance if they don't get a physical may not be the optimal way to improve workers' health or lower insurance costs, but we sympathize. (There's a lot of evidence that a carrot works better than a stick, but more on that later.)
When you get an annual physical, if you find out you have high cholesterol and start taking a statin, for example, you'll lower your risk of heart disease and lower long-term health-care costs for you and your company. Win-win.
Now, about that carrot (so good for you): Dr. Mike's Wellness Center advises many companies on wellness issues for their employees. And when companies offer incentives and rewards (cash) instead of penalties for losing weight, quitting smoking and reducing high blood pressure and lousy LDL cholesterol, employees see lasting improvements in their health, and companies see huge savings.
Even though your company isn't that progressive, you should take advantage of the annual health checkup to launch your own health-improvement campaign. You'll gain a lot more than $600 -- a longer life, happier outlook, less stress, better sex and more self-confidence, for starters.
Q:I heard most fish-oil supplements don't deliver the health benefits they claim. If that is true, what's a good alternative? -- Anon.
A:Fish-oil supplements are just that, supplements, and therefore not tightly regulated by the U.S. Food and Drug Administration. Most of the omega-3 fish-oil supplements that are on the market today are EPA and DHA EE (ethyl ester) concentrates, or what we call resynthesized fish oil. The problem is that resynthesized ethyl ester fish oil contains a form of DHA that keeps natural DHA from doing its job on a molecular and cellular level. And the EE concentrates only have about 50 percent of the bioavailability of the true omega-3s (EPA and DHA) that come straight from fish or algae (which is where the fish get theirs). This matters, because many people take fish oil to help lower their blood pressure, reduce body-wide inflammation, prevent heart disease and cancer, and manage type 2 diabetes.
Be vigilant about reading the labels and double-check that your fish oil is not an ethyl ester or EE; it should be a triglyceride (TG). If it doesn't say it's TG, look for another source. When you do, there are some easy options:
1. Get your omega-3 DHA from algal oil supplements. We do; microalgae are what fish eat to make their omega-3s.
2. Get DHA two or three times a week from a 3- to 4-ounce serving of salmon or ocean trout. These are the only two fish commonly available in the U.S. that are sure to have enough DHA.
3. Or be super-safe and go for options 1 AND 2. We take 900 IU of algal-oil DHA a day as an insurance policy, in case we miss our serving of salmon.
Dr. Mehmet Oz is host of "The Dr. Oz Show," and Dr. Mike Roizen is chief medical officer at the Cleveland Clinic Wellness Institute. Submit your health questions at www.doctoroz.com.
Company uses 'stick' to promote good health habits
Q:My company now requires an annual health checkup to assess our weight, height, body fat and blood pressure, or we end up paying $50 more a month for health insurance. They say they won't penalize us for "bad" results, as long as we get the checkup. What do you think? -- Mike P., Ocala


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All great affairs begin somewhere. For us, it all started at Le Méridien Etoile, located in the charming 17th arrondissement of Paris.
Located in the city's first skyscraper built in 1952, the hotel blends timeless chic design with Southern hospitality.
Nestled on a dazzling islet surrounded by a private lagoon, this hotel sets the stage for an unforgettable tropical getaway.
Toast tradition at Le Méridien with Au Soleil: A Summer Soirée by Le Méridien, a series of Sparkling soirées celebrating classic Parisian pastimes.
When it comes to a great meeting of the minds, Le Méridien has everything you need. Discover Creative Meetings and unlock innovation.
With +100 hotels around the world, Le Méridien invites you to discover the world in style, savour the moment and enjoy experiences that offer something more than meets the eye.


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Pablo Martinez Monsivais / AP
President Barack Obama greets supporters Friday during a campaign event at Strawbery Banke Museum in Portsmouth, N.H.
President Barack Obama traveled to Portsmouth, N.H., looking to maintain the momentum from his Thursday night Democratic convention address despite a disappointing jobs report released Friday morning.
Trying not to put too much of a damper on the event – his first since his convention prime-time acceptance speech -- the president sought to put a positive light on the jobs report, which showed a lower-than-expected 96,000 jobs created in August and an 8.1 percent unemployment rate.
"Today we learned that after losing around 800,000 jobs a month when I took office, business once again added jobs for the 30th month in a row," he told the 6,000-person crowd at the Strawbery Banke Museum.
"But that's not good enough," he continued. "We need to create more jobs faster. We need to fill the hole left by this recession faster. We need to come out of this crisis stronger than when we went in."
He spent much of the rest of his speech hitting similar notes as he did Thursday night – explaining in broad, aspirational language his goals for a second term, including adding a million jobs over the next four years; cutting oil imports in half by 2020; improving access to education and overhauling the tax code.
He also, as he did Thursday night, ridiculed Republicans for what he said was a plan that relied solely on tax cuts for the wealthy intended to encourage economic growth among lower-income people.
"All they've got to offer is the same prescriptions that they've had for the last 30 years: tax cuts, tax cuts, gut some regulations -- oh, and more tax cuts," he said. "Tax cuts when times are good, tax cuts when times are bad, tax cuts to help you lose a few extra pounds -- (laughter) – tax cuts to improve your love life -- I -- it'll cure anything, according to them," he joked.
It was a similar line to one he used Thursday night, when he also characterized Republicans as depending on tax cuts as a cure-all.
"Feel a cold coming on? Take two tax cuts, roll back some regulations and call me in the morning," he joked at the Time Warner Cable arena in Charlotte, N.C., at the convention.
On the flight from Charlotte to Portsmouth, White House senior adviser David Plouffe downplayed any sort of positive effect the convention would have on the president's standing in the polls.
"We come out of the convention with momentum. That doesn't mean the race is going to change significantly. But we think that we come out of here with some momentum in terms of putting together the electoral picture," he told reporters traveling on the president's plane.
Obama went on to Iowa City, Iowa, where he was to address students at the University of Iowa. He will then travel to St. Petersburg, Fla., where on Saturday he will kick off a two-day bus tour.


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? Embedded software Engineer
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? Automotive software Engineer
This course contains Automotive electronics, deals with applications of ECUs. In-vehicle networks description and working, automotive standards in the industry.
? AUTOSAR: need of autosar, layered architecture in an automobile, Methodology of implementation, application layer, simulation of various modules in simulation tools like CANoe etc
Automotive Engine controls Training (In Class)
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Target area of training:
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The course is Intended for Car Enthusiasts & who are seeking Job in Automotive industry. The course is developed for the engineers/technicians who thrust to support OEM manufacturers to meet Performance, Fuel consumption, Emissions, & other customer demands.
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NRIS.COM is one of the premier NRI website that provides a range of resourceful services to Indian expats residing in the USA. Visiting the site you will find comprehensive information related to restaurants, casinos, pubs, temples, carpool, movies, education, real estate, and forums. The simple and easy to navigate format allows NRIs to gain information within a fraction of a second. Moreover, advertising through its column of Indian free classifieds in USA allow businesses to improve visibility of their brand.


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N M Tech President Lopez Named to Power Broker Alumni List, Sept. 26, 2006
SOCORRO, N.M., Sept. 26, 2006 – New Mexico Tech President Daniel H. López has been named again as one of the state's top "power brokers" by New Mexico Business Weekly in its recently published 2007POWER Book. This marks the fifth year in a row the university president has been included in the annual directory of "who's who" among the state's education, business and political communities.
In particular, López was cited as one of five "POWER Alumni" listed in the education section of the recently published Power Book. The New Mexico Tech President is featured alongside fellow higher education administrators from New Mexico State University and the University of New Mexico.


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CHIPPEWA TWP. � Gravy was still warm. Dallas Cowboys were still in uniform. Thanks were still being given across the country as the pilgrimages to the stores began, heralding a new era of American consumerism.
Lured by earlier-than-ever Black Friday sales, people left Grandma and Grandpa in search of Samsung and Toshiba. They did not go blindly: In dozens of interviews, people acknowledged how spending has become inseparable from the holidays. Older folks pined for the days of Erector Sets and Thumbelinas while in line to pay iPad prices. Even some younger shoppers said it felt wrong to be spending money instead of quality time on Thanksgiving.
�But we�re still out here,� said Kelly Jackson, a paralegal who was standing inside a Best Buy store in the Pittsburgh suburbs, a 32-inch television ($189) in her cart. It was a consolation prize: Despite four hours in line, she missed the cheaper 40-inchers ($179) that she had heard about while listening to Internet radio.
Jackson�s resignation was common among those who flocked to capitalism�s temples for the consumer equivalent of genuflecting. Many said that this Black Friday bled into Thursday crossed a line, that merchants should not intrude like this. Christmas is about the message of Jesus, the feeling went � not about the gold, frankincense and myrrh.
Yet amid these protests, people still talked about feeling powerless beneath the moment � as if they had no choice but to shop.
�You have to have these things to enjoy your children and your family,� said Jackson�s friend Ebony Jones, who had secured two laptops ($187.99 each) for her 7 and 11 year olds.
Why must we buy? To demonstrate our love for others? To add a few more inches to our televisions? To help America recover from a vicious recession that itself was born of the desire for more?
Such questions make Jones wince. �It shouldn�t be that way, but in a sense there�s no way around it,� said Jones, a nurse. �Everything ends up with a dollar amount. Even your happiness.�
Retailers have long capitalized on the holiday season�s perfect storm of emotion and tradition. �We all want to be loved, we all like to give love,� says Roger Beahme, director of the Center for Retail Innovation at the Wake Forest Schools of Business. Through a flood of advertising on TV, radio and newspapers, he says, retailers can create emotions.
�Will Rogers said it�s the art of convincing people to spend money they don�t have on something they don�t need,� Beahme says. Although advertising can serve useful purposes, he says, �there�s some truth to that.�
Many embrace the feeling � and have, in accelerating ways, for a generation and more. Without legions of believers, Black Friday never would have gotten this bold. Despite a surge of resistance as the sales drew near, with scolding editorials and protests by retail employees and reminders of frantic tramplings past, Black Friday�s grip on America may have been proven stronger than ever this year.
�It�s all part of the holiday � part of the tradition,� said Dennis River, a truck driver who was in line for a television at the Walmart in Chippewa Township. Last year, he went out alone at midnight Thursday. This year, he brought his wife and daughter. They were in place by 7 p.m.
�You get up in the morning, cook, do your dinner and your football, then you go shopping,� River said. �It�s the new thing now. Everyone�s afraid of change.�
�If they wanna have sales today,� he said, �I�m gonna go shopping today.�
Walmart�s cavernous store is always open, but the deals began at 8 p.m. As with most big retail stores, a police car was parked near the Chippewa store entrance. A uniformed officer was at the door, near a stand holding maps to �featured products� such as bikes, cookware, sheets, video game consoles, and eight different TVs.
The witching hour approached. Yellow CAUTION tape cordoned off the bargains and funneled a few thousand supplicants through aisles of ignored items � yarn, shower curtains, party hats, clocks. Balloons printed with dollar signs followed by low numbers floated above the treasures.
As the cell phones struck eight, a din arose. Excited voices mixed with the sound of boxes dropping into metal shopping carts. The balloons danced as people dug into stacks of leather ottomans ($29) and 5-by-5 foot bins of $5 DVDs.
The temperature climbed. An old man inched through the throng using a folding chair ($11.88) as a crutch. Traffic jammed. Complaints and a few curses echoed.
�I�m not an angry person, but I was angry for the 20 minutes I was in there,� Danyel Coyne, a college student, said as she loaded a child booster seat ($12.98) into her trunk.
She and her boyfriend, Mike Yanke, had not come to shop. They needed a spare car seat to take Yanke�s daughter back to Pittsburgh. Yet Yanke still had bought a red, battery-powered convertible ($129) at his dad�s request.
�I wouldn�t say Black Friday has taken over,� said Dave Davies, a music producer who was part of the national parade of TVs (his was 50 inches and $399). �Shopping IS the holiday. That�s all people care about � what are you gonna get?�
For some, the items themselves can even take a back seat to the simple act of shopping.
Childhood friends Jesse Bredholt, Ryan Seech and a few other buddies have camped out at Best Buy for four years straight. This year, they arrived a full week early, with a tent, sleeping bags, deodorizing mist sprayer, propane heater and battery power for their gadgets.
They had no idea what they would buy. That was not the point.
For this group of single men in their early 20s, part of a generation who mark the passage of time by their first cell phones and video games, the point is spending time with each other at the source of the products that have always defined their lives.
�Our family is here,� said Bredholt, who works for a health-care company. �With five guys on one mattress, you gotta be family.�
Karen Jefferson, 49, also has found family on line at Best Buy, beyond her husband and three children. She was there Wednesday, seated on a folding chair, clutching a rolled-up circular.
�I�m missing Thanksgiving, and my husband thinks I�m crazy,� said Jefferson, who works at a mortgage insurance company. �But I do this every year . because I enjoy meeting people and the people that come when I do. I mean, you see the same people year after year. And I do get some very good deals.�
What about studies that have shown better deals are available at other times of the year?
�Oh, really?� Jefferson said. �You just think, Black Friday! Oh, my gosh, that�s the deal of the year.�
�Maybe that�s something I need to look into,� she continued. �Because, I mean, if these aren�t good deals, then what are we DOING then?�


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December 06, 2006
Approval of and request for public comment on interim rule that would implement section 601 of the Financial Services Regulatory Relief Act of 2006, amending Regulation O
For immediate release
The Federal Reserve Board on Wednesday announced the approval of, and invited public comment on, an interim rule that would implement section 601 of the Financial Services Regulatory Relief Act of 2006, which eliminated several statutory reporting and disclosure requirements relating to insider lending by insured depository institutions. The Board proposed and supported eliminating these statutory reporting and disclosure provisions because the federal banking agencies have not found them particularly useful in monitoring insider lending or preventing insider abuse.
The interim rule would amend the Board's Regulation O (12 CFR part 215) to reflect the elimination of these reporting and disclosure requirements. Regulation O implements statutory restrictions on the ability of insured depository institutions to extend credit to their executive officers, directors, principal shareholders, and to related interests of such persons (insiders). The interim rule does not alter the substantive restrictions on loans by insured depository institutions to their insiders or to insiders of their correspondent banks.
Because section 601 of the act became effective on October 13, 2006, the interim rule would be effective immediately upon publication in the Federal Register. The Board is, however, seeking public comment on the rule for a 30-day period.
The Board's notice is attached.


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Custom AMC Theatres Gift Cards
AMC Theatres offers custom gift cards for sale in their online store. You can choose between a traditional design or add a photo to create your own custom AMC Theatres gift card. With the traditional AMC designs you are unable to add your own photo but the gift card can still be customized by writing a personal message. The personal message will appear at the bottom of the gift card. The second type of personalized AMC Theatres gift card allows you to upload any photo which is then integrated with an AMC Design, for example you can upload a photo of your friend and it will appear on a movie theater screen within the gift card. In addition to uploading a photo the personalized AMC Theatre gift card can also include a short message.
The traditional AMC gift card with a personal message does not have any additional fees. The personalized AMC gift cards costs $4.50 which includes the card processing, printing and card carrier fees.
Tags: AMC, AMC Gift Card, AMC Gift Certificate, AMC Theatres, Custom AMC Theatres Gift Card, Custom Gift Card, Customized Gift Card, Entertainment Gift Cards, Gift Certificates, Movie Gift Cards, Movie Gift Certificate, Movie Theater, Movie Theatre


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Canon EF 14mm f/2.8L II USM Lens
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The Canon EF 14mm f/2.8L II USM Lens sports one of the widest focal lengths in Canon's L-series lens lineup. The 114º angle of view is ideal for vistas and interiors alike without the distorted quality of fisheye lenses. It can be paired with both full frame sensor cameras, such as the Canon 5D Mark III, and with crop frame sensor cameras, such as the Canon 7D Mark II. The focal length equivalent on crop frame sensors is 22.4, which is still very wide for most small space or landscape shooting applications. It features moisture and dust sealing for use in variable conditions and has near-silent AF. For a similarly performing lens with more range, we recommend the Canon 11-24mm f/4L. The Canon 14mm f/2.8L is ideal for low light shooting, thanks to its wide maximum aperture, and for landscapes, vistas, cityscapes, interiors, and real estate photography.


text:
by l M Jones
(Holyhead )
Biodiversity Under Threat - Penrhos, Holyhead
Dear Wil
Comments for Red squirrels of Penrhos Nature Reserve Holyhead Under Threat!
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Make Your Anglesey Holidays Really Special
Anglesey Hidden Gem and Appalling Lies & Inspiring Missives
Create more wonderful memories and experiences for you and your family and friends when you visit Anglesey.
It is a simple and obvious thing to say, that any view or place is improved significantly when you have stories and knowledge attached to what you are viewing.
May I therefore invite you to have a look at my book 'Anglesey Hidden Gem'.
This book is full of the known and unexpected places off the beaten path you might wish to visit and offers you stories that will bring to life the distant and recent past.
Please click on the image above for more information.
By the way, Anglesey Hidden Gem is currently part of my Easter Book Sale with greatly reduced prices for this week.
You may also like to learn of who we are on Anglesey, of our history, character and especially our humour.
In 'Appalling Lies & Inspiring Missives from Anglesey' I offer you the opportunity to learn about us.
It is available in both Kindle and Paperback versions.
Also part of my Easter Book Sale with greatly reduced prices for this week.
Books by William Gerwyn, author of
this web site.
Now in Paperback
Winning Beaches
May 10, 19 09:04 AM
Hi I have been wanting to bring my horse to newbrough forest but where do you park and What route do you take xxx Thank you Rhian McFadden
Apr 24, 19 05:26 AM
Anglesey Book Store for those interesting books and MUST HAVE reading and Planning for your Anglesey holiday and education
Apr 16, 19 06:04 PM
Hello Wil The Devil Stone.is said to be now inside the church according to Wiki.p I would love to see inside the church. Do you know how we could get


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OHL: Menard leads Battalion past Wolves 4-1; Brampton leads playoff series 1-0NHL.com @NHLdotcom
Francis Menard scored and added two assists as the Brampton Battalion defeated the Sudbury Wolves 4-1 on Thursday to take a 1-0 series lead in their Ontario Hockey League first-round playoff series.
Barclay Goodrow scored the game-winning goal 41 seconds into the second period for Brampton, while Matt MacLeod and Dylan Blujus had its other goals. Patrik Machac chipped in with a pair of helpers for the home side.
Matt Schmalz had Sudbury's only goal.
MacLeod opened the scoring on the power play a little over three minutes into the game. That score held until Goodrow's goal early in the second period. Blujus scored with the man advantage to give the Battalion a 3-0 lead with less than two minutes to play in the second.
After Schmalz gave Sudbury some life two minutes into the third, Menard rounded out the scoring at the 8:30 mark of the final period, providing some added insurance.
Matej Machovsky stopped 17 of 18 shots for Brampton while Franky Palazzese allowed four goals on 27 shots.
Brampton went 2 for 3 on the power play, while Sudbury failed to capitalize on their two chances with the man advantage.
Game 2 goes Sunday afternoon in Brampton.
Elsewhere in the OHL it was: Sault Ste. Marie 1 Owen Sound 2 (OT); Mississauga 1 Belleville 8 and Kingston 1 Barrie 3.
Attack 2 Greyhounds 1 (OT)
(Owen Sound leads series 1-0)
At Owen Sound, Ont., Daniel Milne scored in overtime to give the Attack a 2-1 victory over Sault Ste. Marie. Game 2 is in Owen Sound on Saturday.
Bulls 8 Steelheads 1
(Belleville leads series 1-0)
At Belleville, Ont., Brendan Gaunce scored twice to lead the Bulls to an 8-1 victory over Mississauga. Game 2 of the series goes Saturday in Belleville.
Colts 3 Frotnenacs 1
(Barrie leads series 1-0)
At Barrie, Ont., Mathias Niederberger made 33 saves as the Colts defeated Kingston 3-1. Game 2 of the series is Saturday night in Barrie.


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- 22h
- Event Facebook
Drawing inspiration from the work of the legendary Fela Kuti, these nine stellar musicians use their jazz experience to expand on the foundation sound with a modern urban touch. Afrodizz knows how to make you move and make you think. Their live performances are bonafide dance floor burners.


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Coded Arms Contagion thrusts players into a new cybernetic crisis. Use your hacking abilities and an arsenal of high-powered weaponry to survive A.I.D.A., a virtual reality military training program. Cyber-terrorists are taking control of the program and gaining access to classified military information. You`ll have to disinfect AIDA from the hacker-introduced virus to escape the system. Take on original enemies with an all-new selection of firearms and explosives that counters the terrorist menace with more firepower than ever before.
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