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Dick Tufeld, a longtime radio and TV announcer who intoned
as the voice of the Robot in the 1960s science-fiction TV series "Lost in Space," has died. He was 85.
Tufeld died Sunday at his home in Studio City while watching the NFL playoffs, his family said. He had heart disease and had been in declining health since sustaining a fall last year.
In "Lost in Space," producer Irwin Allen's futuristic retelling of the "Swiss Family Robinson" story that aired on CBS from 1965 to 1968, actor
wore the Robot costume and Tufeld provided the voice.
Besides warning young Will Robinson of impending danger, Tufeld's Robot uttered other lines that became catchphrases for faithful viewers — including "That does not compute" — and needled the antagonistic Dr. Zachary Smith with barbs like "Dr. Smith is a bubble-headed booby."
Tufeld was the announcer for Allen's other TV shows, including "Voyage to the Bottom of the Sea" and "The Time Tunnel," and his narration and other voice-over work could be heard on an array of TV programs. He introduced many Walt Disney productions, notably the 1950s TV series "Zorro" and Disney's long-running prime-time anthology series.
His other TV credits from the '50s through the '90s included "Spider-Man and His Amazing Friends," "The Fantastic Four," "The Gallant Men," "Surfside 6," "Annie Oakley" and variety shows starring Judy Garland and Julie Andrews.
Richard Norton Tufeld was born Dec. 11, 1926, in Los Angeles to Tanya and Bentley Tufeld and raised in Pasadena. He grew up entranced by the radio fiction of "The Shadow" and "The Green Hornet" and rehearsed his own play-by-play accounts of sporting events.
After studying speech at Northwestern University in Evanston, Ill., he returned to Los Angeles and began working in radio. Beginning in 1949 he was the announcer for ABC radio's "The Amazing Mr. Malone" and "Falstaff's Fables" before becoming the narrator for
a science-fiction serial on radio.
"Space Patrol!" Tufeld cried out at the beginning of the show. "High adventure in the wild vast reaches of space ... missions of daring in the name of interplanetary justice. Travel into the future with Buzz Corry ... commander-in-chief of ... the Space Patrol!"
Tufeld also worked as a sports and news announcer for local TV and radio stations and narrated hundreds of
He returned as the voice of the Robot in the 1998 "Lost in Space" feature film. By 2004 he was still playing the Robot, for an episode of "The Simpsons."
Tufeld's wife of 56 years, Adrienne, died in 2004. He is survived by sons Bruce and Craig, daughters Lynn and Melissa, six grandchildren and a brother, Howard "Bud" Tufeld.


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Holly Lee – Babe of the Day
Holly Lee is an international model based in California who makes us yearn to be out in the Golden State.
This girl is fit in every sense of the word and prompts many of us to start going back to the gym just to have a chance with her. Even if we became muscle-bound gods, we'd probably still get tongue-tied around this beauty.
Check out her Facebook, Instagram and her official site for more.

subset: commoncrawl


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Au Pair Gold Coast – The Gold Coast is a metropolitan region south of Brisbane on Australia's east coast. It's famed for its long sandy beaches, surfing spots and elaborate system of inland canals and waterways. It's also home to theme parks such as Dreamworld, Sea World and Wet'n'Wild. Inland, hiking trails crisscross Lamington National Park's mountain ridges and valleys, home to rare birds and rainforest.
An au pair is a domestic assistant from a foreign country working for, and living as part of, a host family. Typically, au pairs take on a share of the family's responsibility for childcare as well as in some instances some light housework, and receive a monetary allowance for personal use as well as board and lodgings. Au pair arrangements are subject to government restrictions, which specify an age range usually from mid-late teens to mid to late twenties; some countries explicitly limit the arrangement to females.
A host family is a family consisting of at least one parent and one child under the age of 18 that invites an au pair from a foreign country for a specified period of time. The au pair lives "on equal terms" with the other members of the family and in return for food, board, and a salary, cares for children and does simple domestic work. Hosting an au pair is considered a program of cultural exchange
Arrangements differ between Europe, where the concept originated, and North America. In Europe, au pairs are only supposed to work part-time, and they often also study part-time, generally focusing on the language of the host country. In the United States, they may provide full-time childcare. In 1969, the European Agreement on Au Pair Placement was signed, and it came into force in 1971.
Why Wait? Sign Up And Start Searching Today!
Au Pairs, Wwoofers and Host Families can create a profile on our easy to use platform by registering at www.aupairhorizon.com.
Once registered and your profile has been completed, your able to begin your search for that perfect match. Please note that even though you may be able to view profile snippets from all of our members, full profiles will be restricted to certain subscriptions and paying members.
Host Families, wwoofers and Au Pairs can favourite other members in order to let them know they are interested. Once you're a member, your also able to private message other members to be able to initiate contact, ask any questions that you may have and then arrange further contact, we'd recommend over Skype where you can see the other person. We'd also recommend that you Skype numerous times to ask as many questions as possible and get a genuine feel and see if they are the best possible match.
Au Pair Horizon does not participate in the matching process. We only offer an easy to use platform.
Why Wait? Sign Up And Start Searching Today!
An online profile is one of the most important steps for any au pair searching for a family or vice versa. Each party uses the profile to get to know the other before scheduling an interview. It is therefore crucial that au pairs and host families have a professional profile that is up to date at all times with working contact details. All members need to be aware that having private information publicly available could have its disadvantages so users need to be vigilant. It is therefore important to have a private working email.
Here are a few important tips on building a successful online profile:
• BE truthful and honest at all times, this is so important.
• Make sure that your information is up to date.
• Upload images! Profiles with images get way more views.
• Be descriptive but give concise answers where possible.
• For a host family, use the Introduction section or further information section to further explain your requirements, provide information about the accommodation, local area and possible local language classes that they could attend.
• For an Au Pair, use the Introduction section or further information section to further explain what you'd like to gain out of the experience, use it to provide further information about experience that you may have or an example of where you've demonstrated responsibility. Families also like to see examples of experience with children as well as any training courses that you may have participated in like first aid courses.
Throughout our site you can find a large amount of useful tips and hints on becoming an au pair, wwoofer or host family.


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Karaoke ~ Trivia ~ Photo Booth ~ Lighting
Prime Time Photo Booths
DJ Trivia
Add Your Title Here
This area can be fully edited
This area can be fully edited and gives you the opportunity to introduce yourself, your website or company, your products or services.
This area is fully editable and you can use it to promote your products, services and facilities. You could also use it to introduce your team, their roles and why they are so important to your business.
Add Your Sub-Title Here
What you write here is totally up to you, there is no right or wrong way to complete your 'About Us' page.
We advise making your language friendly and approachable, while being informative and professional.
You should also consider adding key information such as:
* How many years experience you have
* Your contact details
* Local areas you cover
* Your policies
* Any additional services you offer
* Why people should choose you


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KSP News:
KSP Releases 2013 World Championship Tour Schedule
Maui, Hawaii — February 1, 2013: Following it's second consecutive season, which saw competitive kite surfing being pushed to epic new heights, the KSP is pleased to announce the schedule for it's highly anticipated 2013 Tour.
The 2013 KSP World Championship Tour is set to kick off at Guincho Beach, Portugal, winner of KSP's recent Facebook poll, and will again feature the birthplace of kite surfing, Maui, Hawaii. Two exciting new venues will also be included in the 2013 Kite Surf Pro World Championship Tour - Gran Canaria and Puerto Rico. With these exciting destinations on the map, the 2013 KSP season once again promises nothing short of phenomenal surf conditions for the world's kite surfing elite to battle it out for the coveted IKA-sanctioned World Championship title.
Just as last year, the 2013 KSP Tour will kick off at Europe's premier kitesurfing beach break, Guincho Beach in Cascais, Portugal, from June 27 to July 6. The powerful right-hand beach break and strong side-onshore winds at Guincho are ideal to elevate the level of exciting and progressive aerial surfing to the forefront of competition.
Next up will be another perfect playground for progressive above-the-lip kitesurfing, offering strong side-onshore winds from the left and punchy surf - Jinamar Beach on Gran Canaria. The Canary Island will welcome the KSP to its windy and wave-rich shores for the first time when riders battle it out for the event title from July 25 to August 2, 2013.
Stop three takes the KSP to another new and exciting venue - the beautiful Caribbean island of Puerto Rico. From October 31 to November 9, 2013 Shacks Beach will become the epicenter of the kite surfing world and show why Puerto Rico is widely considered the secret kite surfing jewel of the Caribbean.
Bringing the Kite Surf Pro World Championship tour to a close for the second year in a row, Maui's legendary North Shore will host the 2013 KSP World Tour finals from November 22 to December 1. With near-perfect down-the-line surfing conditions, Ho'okipa will once again offer an ideal stage for the culmination of the dramatic KSP World Title race.
"It's shaping up to be an awesome year," says Tour Manager Terry McKenna. "It's going to be a well-rounded tour with a good variety of venues that will cater to the diversity of styles. Guincho and Gran Canaria will showcase the progressive aerial aspect of the sport whilst Ho'okipa and Puerto Rico will offer the purists a chance to illustrate a more power-based style of on-rail surfing. I'm really looking forward to meeting and working closely with local organizers and to make this a memorable year for the KSP," Mckenna added.
As reigning World Champions Keahi De Aboitiz (AUS/Cabrinha) and Jalou Langeree (NED/Naish) look to defend their titles amidst a field of the top 24 men and 12 women umpired by an International Surfing Association-accredited panel of judges, each KSP event will once again feature live webcast with live scoring, broadcasting the heat-by-heat action in real time.
2013 KSP World Championship Tour Schedule:
June 27 to July 6, 2013 — Guincho, Cascais/Portugal
July 25 to August 2, 2013 — Jinamar, Gran Canaria/Spain
October 31 to November 9, 2013 — Shacks/Puerto Rico
November 22 to December 1, 2013 — Ho'okipa, Maui/USA


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Students experience the thrill of authorship
Album 1
on photos below to enlarge.]
[May 21, 2014]
Send a link to a friend
On Friday, Northwest School in
Lincoln hosted a Book Premiere featuring the fabulous writings its
students created this past school year. Elementary students from
second through fifth grades participated in the writing project that
took student's works and put them into book form.
The program was so popular
with the students last year, that this year it was expanded to
include a public presentation, during which some of the children
were given the opportunity to read their submissions aloud.
Pictures by Jan Youngquist
Click here to go to Album
Back to top


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Nicholson's breakfast
Gloucester Old Spot sausage, crispy smoked bacon, golden hash brown, roasted mushroom, free-range eggs cooked to your liking, plum tomato, black pudding, baked beans and a freshly toasted muffin
16 Newburgh Street, London, Greater London, W1F 7RY 020 7494 9748
All our food is prepared in a kitchen where nuts, cereals containing gluten and other allergens are present and our menu descriptions do not include all ingredients.
If you have a food allergy or intolerance, please let us know before ordering. Full allergen information for food and drink is available, upon request. Fish dishes may contain small bones.


text:
It's true. It's all true. And I'll validate it for you.
You have no talent.
You're never going to succeed.
Your agent isn't doing shit for you, and you won't find anyone better.
You can't make a living at this.
You're not a real writer.
Your publisher isn't behind you.
Your work-in-progress stinks.
Your peers don't respect you.
The bad reviews are true.
Everyone is doing better than you are.
You're fooling yourself.
You'll never get another contract.
The whole world knows you suck.
Your last book was better.
No one else struggles.
You need to quit, because you don't have what it takes.
You done? Got that out of your system? Good.
Now quit being a whiny little baby and go write.
Saturday, December 02, 2006
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text: [i:Vibes] :: View topic - Pablo Muzi3k - The Wetlands EP [Rezongar Music] Guidelines FAQ Search Memberlist Usergroups Bookmarks Register Profile Log in to check your private messages Log in Main Menu Frontpage News Reviews Interviews Party Reports Artist Profiles Label profiles Diaries Tutorials What is... Links Radio-info Interactive Forum User Stats Info FAQ Crew-info i:Vibes Info Site Updates Pablo Muzi3k - The Wetlands EP [Rezongar Music] [i:Vibes] Forum Index -> Artist and Label News View previous topic :: View next topic Author Message joefisherFeeling The MusicVibes: 33.12Joined: 20 Jul 2009Member #: 40,697Posts: 145 Post subject: Pablo Muzi3k - The Wetlands EP [Rezongar Music] Out Now on Rezongar Music Pablo Muzi3k - The Wetlands EP [RZG133 01. The Wetlands (Original Mix) 02. The Wetlands (Andre Gazolla Remix) Release Date> June 22nd, 2017 Buy @ Beatport> https://www.beatport.com/release/the-wetlands/2040724 Listen @ Soundcloud> https://soundcloud.com/rezongarmusic/sets/pablo-muzi3k-the-wetlands-ep Watch @ YouTube> Gazolla Remix https://youtu.be/keQzDUH3bw0 Original Mix https://youtu.be/oFF9AT-lmzE Selected Feedbacks> Franco Bianco "DL Andre Gazolla Remix for possible radio broadcast" Luis Nieva "Nice release, thanks" Alex Preda "Oh yes, I like these! I'll test them out" Sam Divine "Cool vibe on Andre Gazolla Remix" Alex Nemec "Good stuff, defo playing Andre Gazolla Remix" Alex Young "Andre remix sounds great" Brian Gros "Great Tracks! I love it!" Pedro Mercado "Nice underground track!" Nick Clarke "Cool Andre Gazolla Remix" Raphaël Marionneau "Lovely track The Wetlands (Original Mix)" D'JAMENCY "Solid techno EP, thxx" Demos> We are receiving fresh unsigned music at firstname.lastname@example.com Radio Show> Rezongar Music Radio Show http://www.mixcloud.com/RezongarMusic Links> http://www.facebook.com/pages/Rezongar-Music/154538354596075 http://www.soundcloud.com/rezongarmusic Post rating: 0 Rate this post: Not logged in Posted: Mon Jun 26, 2017 6:51 pm Back to top Display posts from previous: All Posts1 Day7 Days2 Weeks1 Month3 Months6 Months1 Year Oldest FirstNewest First [i:Vibes] Forum Index -> Artist and Label News All times are GMT Page 1 of 1 Jump to: Select a forum Spam----------------Spam posts Music----------------Music discussion (trance, techno, progressive and other genres)EquipmentArtist and Label NewsRadio BroadcastsMusic Production and DJ Mix PromotionClub Listings Non-music related----------------Other discussionBuy & Sell [i:Vibes]----------------Site Feedback and Help Content Discussion----------------News DiscussionReview DiscussionInterview DiscussionTutorial DiscussionWhat is...Party ReportsArtist ProfilesLabel Profiles You cannot post new topics in this forumYou cannot reply to topics in this forumYou cannot edit your posts in this forumYou cannot delete your posts in this forumYou cannot vote in polls in this forumYou cannot attach files in this forumYou can download files in this forum Powered by phpBB © 2001, 2005 phpBB Group


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"Girls Gone Wild" Season 14 Episode 10
Nick Stokes (George Eads, left) and D.B. Russell (Ted Danson, middle) tend to Sara Sidle (Jorja Fox) as she sits in an ambulance wondering how a spa weekend for her, Finlay and Morgan turned into a murder investigation and missing persons report, on CSI: CRIME SCENE INVESTIGATION, Wednesday, Nov. 27 (10:00-11:00 PM, ET/PT) on the CBS Television Network. Photo: Robert Voets/CBS ©2013 CBS Broadcasting, Inc. All Rights Reserved


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|Jepson Flora Project: Jepson Interchange
previous taxon |
next taxon
Jepson Interchange (more information)
©Copyright 1993 by the Regents of the University of California
Annual to tree
Leaves generally compound, alternate, stipuled; leaflets generally entire
Inflorescence: generally raceme, spike, umbel or head; flowers sometime 12 in axils
Flowers generally bisexual, generally bilateral; hypanthium generally flat or cup-like; sepals generally 5, fused; petals generally 5, free, or the 2 lower ± fused; stamens 1many, often 10 with 9 filaments at least partly fused, 1 (uppermost) free; pistil 1, ovary superior, generally 1-chambered, ovules 1many, style, stigma 1
Fruit: legume, sometimes including a stalk-like base above receptacle, dehiscent, or indehiscent and breaking into 1-seeded segments, or indehiscent, 1-seeded, and achene-like
Seeds 1several, often ± reniform, generally hard, smooth
Genera in family: ± 650 genera, 18,000 species: worldwide; with grasses, requisite in agriculture and most natural ecosystems. Many cultivated, most importantly Arachis , peanut; Glycine , soybean; Phaseolus , beans; Medicago ; Trifolium ; and many orns
Reference: [Polhill & Raven (eds) 1981 Advances in legume systematics; Allen & Allen 1981 Leguminosae]
Family description and key to genera by Duane Isely.
Annual or perennial herb from crown, glabrous to hairy; hairs sometimes forked at base, branches parallel with leaf surface, sometimes very unequal
Stem 0 or prostrate to erect
Leaves odd-1-pinnate; leaflets generally jointed to midrib; stipules membranous, sometimes fused around stem at stem base
Inflorescence: raceme, axillary, sometimes head- or umbel-like; flowers 2many
Flower bilateral; calyx 5-lobed; banner outside wings in bud, keel blades with small protrusion at base locking into pit on adjacent wing; 9 filaments fused, 1 free; ovary (and fruit) generally sessile, style slender, stigma minute
Fruit generally 1- or ± 2-chambered, often mottled, generally becoming ± dry; placenta on upper suture
Seeds 2many, smooth, compressed, ± notched at attachment scar
Species in genus: > 2000 species: ± worldwide (380 in North America, 94 in CA including many rare taxa)
Etymology: (Greek: ankle-bone or dice, perhaps from rattling of seeds within fruit)
Reference: [Barneby 1964 Mem NY Bot Gard 20:11188; Isely 1986 Iowa State J Res 61:157289]
Very difficult; both flower and fruit needed for identification; many good species appear similar; some species complexes need study. Taxa near province boundaries may appear in > 1 key. Varieties keyed under species for simplicity; species with vars. so identified in key. Fr length includes beak and any stalk-like base unless fruit body specified.
Perennial, ± cespitose; herbage hairs generally 0.61.3 mm, straight and wavy, entangled, grayishSee the CNPS Inventory for information about endangerment and rarity.
Stem < 7 cm
Leaf 1.59 cm; leaflets 719, 313 mm, ± widely obovate
Inflorescence: flowers 513, ascending
Flower: petals pink-purple, wings barely < banner, banner 1618.5 mm, recurved ± 40°, keel 14.316.8 mm
Fruit ascending, 1325 mm, 58 mm wide, ± incurved, ± strongly compressed top-to-bottom, abruptly bent at tip, leathery; hairs dense, generally 0.71.5 mm, white; chambers ± 2
Ecology: Dry, rocky areas among sagebrush or pines
Elevation: 17502450 m.
Bioregional distribution: San Gabriel Mountains, San Bernardino Mountains, San Jacinto Mountains.Much like vars. of A. purshii (which have wings << banner, fruit hairs > 1.5 mm, or banner 1015 mm).


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|Creamy Pie Holes
Short review: Sit back and admire the end results of the hard screwing that was just given to these young ladies. There is no guessing as to whether he came or not.
Content Amount: There's no slip with the drip here, it's fully intended for you to see how the mighty loads these fillies are filled with, comes leaking back out for the sake of the cam. Long stringing streams of dude dripping in the whitest of white and the clearest of clear will have you blowing your own load. Pictures and movies from Creamy Pie Holes will make you squeal with pleasure once they bend over and let it go


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Builders Publishing necesitaba un nuevo diseño de impreso o envases y lanzó un concurso de diseño en 99designs.
Un ganador ha sido elegido entre 128 diseños de 17 diseñadores freelance.
Builders Publishing Group
Have you ever thought about building your dream home? There are so many options and so many things that can go WRONG! What to do? Well, now there's an experienced builder who's written a book to help people understand and LOVE the process of building their custom dream home. And we need your help to re-design the cover in a fresh new way.
This is a book jacket redesign project for a custom home builder in Orlando, Florida. The builder Dave Konkol has been creating some of the most beautiful and well designed homes in Central Florida for more than 20 years. He is the founder and president of Dave Konkol Homes, Inc., a custom homebuilding and remodeling company specializing in luxury homes.
We are including a copy of the previous cover design so you can get a feel for what we have used in the past. However, we are NOT looking for a design that mimics or matches this design. We are looking for something new. A fresh take on this book jacket design.
This book is targeted to people who are interested in building an upscale custom home. This is a range that might be called "low-to-mid-range luxury homes." These aren't mansions, but certainly large, unique, custom-designed homes.
Because Dave builds custom luxury homes, the book cover re-design needs to appeal to an upscale market. We are looking for a design that is elegant, timeless, and enticing. Of course we prefer the design appeal to BOTH women and men. However, in our experience it is primarily women who read the book.
We have attached several files for the re-design:
- Book Jacket copy for the front and back covers, as well as jacket flaps
- Author photo
- Suggested Cover photo (but we are open to others if you have a better interior OR exterior home photograph)
- Publisher logo
- Builder's logo
- Previous book jacket cover (again, we are attaching this just so you can see what we used in the past. We are NOT looking for you to mimic this design. We want something fresh and new.)
Here are the Design Words that come to our mind when we think of this new cover redesign: Elegant, Timeless, Warm, Enticing
NOTE: For each design, please submit 2 FILES:
1) the front cover alone
2) the whole jacket
Cover Dimensions:
Front & Back Cover: 6.5" x 9.5"
Spine: 0.5"
Front & Back Flaps: 3.75 x 9.5"
Total Trim Size: 20.75" x 9.5"
Have FUN -- we can't wait to see your beautiful designs!
Oh, and we have a place on the back flap where you can put YOUR name if you like. (You'll see we highlighted it in Yellow in the Cover Copy document.) Hey, it's your design and we'd like to help promote your great work! :-)


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Find A Murder
Mystery Company In Another State
Murder Shows, Murder
Mystery, Murder Mystery Dinner Show
Order Your Own Do-It-Yourself Murder
Mystery Kit, Games & Scripts
Murder Mystery Players
A murder mystery party in Texas is a unique new way to entertain guests. Invite six to eight close friends or family members to your house for a night of role playing and mystery solving fun.
There are several options in which to obtain your murder mystery from. Look online for several different printable versions. You can also choose to buy the mystery in game from or write your own mystery.
Each guest is assigned a role to play. From the start nobody knows how the game will turn out. During the first part of the game each guest is given a fact sheet of clues about their character and the characters around them. When all of the information for that round is revealed and all of the facts are known, the guests move on to the next round. Guests read another sheet of facts pertaining to the mystery. As the conversation goes on and fingers are pointed, more and more of the mystery is unraveled. By the end of the game, after all of the rounds are played, guests should be able to give a few guesses to who the murderer is.
Ask guests to dress up for the occasion. Send each one a few notes about who their character is and a little bit about the era the party is going to take place in. Decorate your home with in the decade of the mystery.
The game can be played at a dinner party. Serve an elegant dinner with several courses in which the game is played around. If the game has to do with a large Italian family, serve a large Italian feast. Be creative with your menu but, make the courses small so nobody fills up on one thing. There is nothing more thrilling and fun to take part in then solving your very own murder mystery.
Texas Event Planning Services
Corporate Event Planners - Events Over $100K
Event Planner - Events between $20K - $100K
Event Planner - Events Under $20K
Entertainment Producers - Top Celebrities, Concerts, Professional Speakers, MC's
Team Builders - Company Picnics, Motivation Games
Texas Audio & Visual
TexasCatering / Food Service
Bar & Wait Staff, Caterers, Picnics and BBQ's,
Private Chefs, Ice & Food Carving
Texas Concert & Game Tickets
TexasConference Call Services
Conference Calling Services, Cheap Conference, Calling Services, Conference Calls
Texas Corporate Gifts
Gift Baskets, Flowers, Custom Chocolate Logos, Corporate Gifts, Golf Gifts/Tee Prizes
Entertainment Producers
Live Bands & Entertainment
Acrobats, MC's Astrology/Palm Readers/Psychics, Bands / Live Entertainment, Boats & Yacht Charters, Caricature Artists, Carnival Games, Casino Night Party, Celebrities, Children's Entertainment, Clowns / Face Painters, Circus Acts, Comedians, Comedy Roasts & Tributes, DJ's Ensembles, Entertainment Producers, Entertainment Agencies, Face Painters, Fortune Tellers, Harpists, Impressionists, Interactive Acts, Interactive Games Jugglers, Look-A-Likes Master of Ceremonies, Misc. Performers, Murder Mystery Show, Murder Mystery Themes, Murder Mystery Scripts Games, Rock Climbing Walls Sailing Lessons & Charters, Trains & Unique Locations, Scavenger Hunts,
TexasGraphic Artists
Graphic Artists, Website Designers
Home Services
Insurance - Auto, Health, Life, Home,
Texas Party Supplies
Party Supplies, Balloons
TexasParty Decorations
Balloon Decorations, Event Decor


text:
Jan. 9, 2005
Orono, Maine - Joe Mack and Hugh Sullivan each won two individual events and one relay event as Yale won 182-109 at Maine Sunday afternoon. Mack took the 100-yard breaststroke (1:02.17) and the 200-yard breaststroke (2:18.37, edging teammate Cameron Hendrick by .26 seconds), while Sullivan won the 100-yard backstroke (55.55) and the 200-yard backstroke (1:57.99). Both were part of Yale's victorious 200-yard medley relay team (1:41.43) as well, along with Alexander Goldsmith and Dave Lange. Yale's Douglas Scott won two individual events as well, taking the one-meter diving (277.50) and three-meter diving (247.88) competitions. Scott, Jeffrey Lichtenstein and Pat Hayden helped Yale sweep the top three spots in both diving competitions.
Other winners for Yale included Kevin Pudas in the 1000-yard freestyle (9:56.04), Gjorgji Gjeorgjievski in the 200-yard freestyle (1:45.83), Reid Madden in the 200-yard butterfly (1:58.09), Lange in the 50-yard freestyle (22.73, just .03 ahead of Hendrick) and Morgan Locke in the 100-yard freestyle (48.70).
Yale is back in action Saturday at Navy with Cornell.


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But regardless of how well they play, the Broncos won't be able to dislodge the San Diego Chargers from first place this week in the AFC West, the NFL's most competitive division.
For the first time in his long career, rookie San Diego Coach Marty Schottenheimer, who draws a bye Sunday, has a complete team that can pass, run and play defense well enough — without its best player, linebacker Junior Seau — to upset the Oakland Raiders.
The pass plays that San Diego used in Week 7 to win, 27-21, were as well thought out as they were brightly polished.
One such, called at the Oakland three-yard line, was a slow-developing play that required San Diego's linemen to hold their blocks while running back LaDainian Tomlinson faked a block until he could sneak into the end zone for quarterback Drew Brees' touchdown pass. For a team that might be en route to a new home in entertainment-capital Los Angeles, that was sufficiently sophisticated.
Schottenheimer Sees the Light
FEW FOOTBALL FANS expect the 6-1 Chargers to hold first place forever against the 4-2 Raiders or the 5-2 Broncos, who, still favored in the AFC West, defeated the 3-4 Kansas City Chiefs Sunday on Griese's passes to tight end Shannon Sharpe, 37-34.
As Schottenheimer knows, he's in a respectable division. In his Kansas City days, he coached the Chiefs into the playoffs seven times. At 59, he's been in the playoffs 11 winters in all, more than any other active coach. The difference at San Diego is that with Brees pitching, he has a pass offense now. His other teams were all locked out of every Super Bowl and into every conservative's dream world. As those people invariably say — and Schottenheimer was once one of them — their life's goal is to run the ball and stop the run.
His change of philosophy came too late in Kansas City to drive the Chiefs into the NFL championship game, which Schottenheimer has never seen. His old associates said it was in Schottenheimer's 10th and final year in Missouri that he finally identified passing as — in Super Bowl terms — the weapon of decision. You can run your way into the playoffs, they said he said then, but not into the Super Bowl. Having proved this in his first 16 NFL seasons, he's throwing a lot now with Brees. And still running, of course. With Tomlinson now. Not long ago, Tomlinson had everything but the will to mix it up with the big guys in the closeness of contact. Or so it looked. But he's changed too, along with his coach. It's a new day in San Diego.
Fines Hurt Players, Suspensions Hurt Team
ONE REASON DENVER struggled in Kansas City is that it was minus its strong safety, the player who on any NFL team is most instrumental in defensing pass plays and running plays both. A high Denver draft choice three years ago, Kenoy Kennedy was benched that day by the NFL, which ruled that while serving the Broncos as their strong safety, he has been making too many head-to-head hits. Those are not only illegal in pro football but unquestionably unsporting.
Kennedy was also fined $25,000 — not enough — and suspended for one game, too much.
Despite the predictable reaction in Denver, strong NFL action was necessary. The first game-time responsibility of the league, as Commissioner Paul Tagliabue acknowledges, is to keep its artists alive and playing football. And that can be properly done only with heavy fines that discourage scofflaws.
The problem with a suspension is that it penalizes the team as well as the player. A number of innocent people go down with the one convict. Nor, to maintain order, are suspensions required. Fines accomplish the same thing — if they're large enough.
The only reason I can think of that Kennedy keeps hitting people illegally — when he knows it will cost him a bunch of money — is that it doesn't cost him enough. He should have been fined $50,000, or more, whatever it takes. He was the one at fault, not his team, and not the football fans of Denver.
Nebraska Hangs Onto Quarterback
A COLLEGE COACH, Frank Solich of Nebraska, also faced a disciplinary problem last week, when he handled it with greater wisdom, which, perhaps, is more than can be said for his approach to Xs and Os.
In the Oklahoma State game Saturday, Solich started his first-string quarterback, Jammal Lord, despite calls for Lord's suspension after he and girlfriend Greichaly Cepero — a Nebraska volleyball player — were cited for disturbing the peace in his apartment one early morning. Solich decision was made more difficult when the volleyball coach suspended Cepero, the team's best player.
There are better ways than suspensions to discipline college athletes, so long as their infractions — parking in handicapped parking spaces or whatever — don't land them in jail. All college players have, for example, privileges that can be restricted, particularly on road trips. For some infractions, a coach can refuse to award the guilty letter-winner a letter. And there are other measures.
The Cornhuskers, true, didn't need Lord to help them lose to Oklahoma State, but if he's the best they have he gave them their best shot in a game they lost, 24-21. Suspensions are unfair to the other players on the team and to the college itself as well as to the team's fans. And they are unnecessary — in either college or pro ball.
NFL Officiating Beats MLB Umpiring
THE NFL IS continuing to do almost everything else right. For one thing, at this time of year when the football and baseball seasons overlap, sports fans can see that there are a larger number of serious officiating problems in major league baseball than in NFL games. In nearly every baseball playoff game this fall, there has been at least one obvious umpiring mistake.
Sports fans notice occasional officiating errors in NFL games as well, but surprisingly few of them are game-deciding errors despite the plain fact that football officials have it tougher than baseball umpires.
In any baseball game, a typical umpire has not much more than one thing at a time to keep track of. Thus the plate umpire spends his night watching a pitched ball. Only if it's in the strike zone is it a strike, theoretically, even though in too many instances instant replay helps television fans see that it's something else.
Base umpires on close plays are basically required to keep track of at most two players, one of whom is often stationary, or close to it. More exactly, the umps are usually obliged to watch only two feet or one foot and one hand.
By contrast, NFL officials are repeatedly confronted by 22 very large, speeding bodies flying around on every play, all bent on damaging opposing players, one way or another, every way they can.
In both large and small things, the NFL remains ahead of the curve. When coaches or players call the NFL's New York office these days, for example, one of Commissioner Tagliabue's associates still answers the phone in person. A live voice. Where else, today, do you get that?
Does 2-5 Keep Rams Out of Playoffs?
THE RAMS KEEP cutting into the 49ers' lead in the NFC West, where after starting 0-5 they are 2-0 in their last two and 2-5 in the standings behind co-leaders San Francisco and Arizona. The 49ers and Cardinals, both 4-2, are headed for an early-season showdown in the NFC's Game of the Week Sunday at Phoenix. So the question for the Rams suddenly is whether they're too far out to catch up.
They have the tools to get back, and stranger things have happened, if not lately. Their most important tool is new quarterback Marc Bulger, who in Week 7 won his second game in a row, leading the Rams past Seattle, 37-20.
One play in the Seattle game tells Ram fans most of that they most want to know about Bulger. At a key moment, he hit wide receiver Terry Holt with a deep corner throw that measured more than half the field, at least 52 yards. Setting up a touchdown, the ball was in the air a good 65 yards on a pass that was as perfectly thrown as any last year by injured starter Kurt Warner.
What's more, during a critical series in the Seattle red zone, Ram Coach Mike Martz showed that he hasn't lost his touch, whatever his critics like to say about him. With his calls in that series, Martz provided a clinic look at how to run the ball on goal-line plays when passing seems inadvisable. In a two-play sequence:
First, the Ram coach put Bulger in an empty-backfield formation, faking pass, and had him hand off to the motion man, Marshall Faulk, who ran the ball to the three-yard line.
Next, faking pass again, Martz sent Faulk racing into the end zone on a draw play.
The playoffs need the excitement that Martz brings to the game. It's a longshot that might even happen.
Quarterback's Immobility Bothers Bucs
AT TAMPA BAY the new coach, Jon Gruden, doesn't seem to be getting the most out of his talent — a crucial aspect of the job that helped make him a winner at Oakland. In Week 7, as the Philadelphia Eagles put down Tampa without an offensive touchdown by the Buccaneers, 20-10, it was obvious again that immobility in the quarterback position inhibits their chance to win.
Gruden's starter, Brad Johnson, though as accurate with a passed ball as some of the league's best quarterbacks, is a pocket passer strictly who, under a rush, is more statue than quarterback. The Eagle rush is pretty stout but not as stout as it looked. If Johnson can't move, backup Rob Johnson apparently can't impress Gruden.
Overall, the Buccaneers' best quarterback has always been Shaun King since they drafted him four years ago. As a passer, King yields to the Johnsons, most critics believe, but in today's football it doesn't help much if a quarterback can pass but can't move — and King moves with distinction.
In training camp last summer, beyond any doubt, the Johnsons appealed to Gruden because they both looked better than King on pass plays in dummy scrimmage. Still, in live competition, which is where the Buccaneers are now, there are few NFL dummies.
Though King wasn't enough passer for his last coach, Tony Dungy, that was because in a conservative organization the passer must complete mostly third-down passes, which takes a picture passer, which King isn't. But he's more likely than Brad Johnson to move around and win close games for Gruden.
Mr. 5 by 5: Five Guesses on Five Big Ones
BEST OF WEEK 8: An Latimes.com reader says that when everyone's through talking about what's happened, she'd like a message on what's ahead. That's easy for her to say. As a disbeliever in inside information, I'd rather infer or conjecture, even if, in a very good week, it leads to fewer wins than losses. So here are five guesses on the NFL's five most interesting games of the week:
Denver by 3 over New England at Foxboro: Although at quarterback the Patriots' Tom Brady might be No. 1 in the NFL, his support network isn't as strong as Bronco quarterback Brian Griese's. And now that they've lost three in a row, the defending champions' confidence may be as shaky as their defense. If, however, they beat Denver, they'll win most of the rest.
San Francisco by 10 over Arizona at 3Com Park: The surprise team of the National Conference — tied now with the 49ers for first in the NFC West — the Arizona Cardinals lack the defense to contain the 49ers' Big Four: Jeff Garcia, Terrell Owens, Garrison Hearst and Kevan Barlow.
Oakland by 5 over Kansas City at Arrowhead Stadium: Will we see the Oakland that beat Buffalo, 49-31, and Tennessee, 52-25, or the Oakland that lost its last two? That is the question. Next year, the Chiefs will be a title-game contender. Not yet. Nor am I ready yet to give up on Rich Gannon or Jerry Rice.
Baltimore by 3 over Pittsburgh at Ravens Stadium: Do you believe in Chris Redman or Tommy Maddox? That is the question. Since taking over the AFC North's co-first place teams, Raven quarterback Redman and Steeler quarterback Maddox have helped straighten them both out, or rather up. The difference here could be the Steeler defense, which doesn't yet look quite right.
New Orleans by 7 over Atlanta at the Louisiana Superdome: Now that Atlanta's young quarterback Michael Vick has warmed up against a couple of teams the Falcons could beat, it will be of interest to see how far he can extend himself against a team they can't beat. The Saints were lucky to turn back the 49ers last week, but they do have more resources (starting with underrated quarterback Aaron Brooks) than most of the NFL's other title contenders.


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Table of Contents
> Severe combined immunodeficiency
Severe combined immunodeficiency
Also listed as:
Combined immunodeficiency, SCID
Related Terms
Author information
Integrative therapies
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Blessed thistle
Related Terms
Antibody, antigen, autosomal recessive, B-cell lymphocytes, B-cells, bacterial infection, bone marrow, bone marrow transplant, combined immune deficiency, combined immunodeficiency, cytotoxic, cytotoxic T-cells, foreign antigen, fungal infection, genetic disease, genetic disorder, graft versus host disease, IgA, IgM, immune defense system, immune system, immunoglobulin, immunoglobulin A, immunoglobulin M, infections, lymphocyte dysfunction, lymphocytes, natural killer cells, neutropenia, NK-lymphocytes, phagocytes, primary immunodeficiency, T-cell lymphocytes, T-helper cells, thymus gland, viral infection, white blood cells, X-linked inheritance, X-linked SCID.
Severe combined immunodeficiency (SCID) is a genetic disorder of the immune system that occurs when the T-lymphocyte system does not function properly. SCID is the most severe type of primary immune deficiency diseases. Primary immunodeficiencies are disorders that occur because part of the body's immune system does not function properly. Unlike secondary immunodeficiencies, which are caused by external factors like viruses or chemotherapy, primary immunodeficiencies are caused by problems that originate within the patient's own body. SCID is usually diagnosed during childhood. A milder form of T-lymphocyte dysfunction causes combined immunodeficiency, which is typically diagnosed in adults.
The immune system protects the body from harmful antigens (foreign substances that enter the body) like bacteria, viruses, fungi, or parasites. A specialized tissue inside bones called marrow produces immune system cells, which are also called stem cells. These stem cells then develop into B-lymphocytes, T-lymphocytes and natural killer (NK)-lymphocytes and phagocytes. All of these cells produce proteins that help them detect antigens that enter the body. The cells and proteins are spread throughout the body to protect the body from diseases and infections.
There are three types of T-lymphocytes: T-helper cells, cytotoxic T-cells, and regulatory (T-reg or T-suppressor) T-cells. When an antigen enters the body, T-helper cells direct B-lymphocytes (B-cells) to make antibodies against it. These antibodies then bind to the foreign substance, which is called an antigen. This binding tells the T-cytotoxic cells to destroy the unwanted antigen. T-reg cells direct the resolution of the immune system response, which means they "turn off" the immune response.
The defining characteristic of SCID is always a severe defect in T-cell production and function. Patients also have dysfunctional B-lymphocytes, which may or may not be caused by the dysfunctional T-cells. Some genetic types of SCID also cause a shortage of NK-cell production as well. Consequently, SCID patients produce little or no antibodies, and they are extremely vulnerable to developing opportunistic infections (infections that occur in individuals with weakened immune systems).
Unless these problems in the immune system are corrected, the child will die from severe opportunistic infections by the age of one or two. Most patients are diagnosed when they are six and a half months old.
There are several types of SCID, including autosomal recessive severe combined immunodeficiency, X-linked recessive severe combined immunodeficiency, adenosine deaminase deficiency (ADA), bare lymphocyte syndrome, severe combined immunodeficiency with leukopenia (reticular dysgenesis), and Swiss-type agammaglobulinemia.
SCID is genetically inherited as either an X-linked (gene on the X chromosome) or autosomal recessive (two copies of a single mutated gene) trait. Each type is caused by a different genetic defect in the patient's DNA. However, the genetic defect has not been discovered for all forms of the disease. Since SCID patients have impaired immune systems, they are vulnerable to diseases and infections. Patients commonly suffer from pneumonia, meningitis, and/or blood system infections.
Without a bone marrow transplant, a child with SCID is at risk of developing a severe or deadly infection. While waiting for a bone marrow transplant, patients are treated with intravenous immune globulin (IVIG), which helps the immune system fight off illness. Antibiotics, antifungals and antivirals are given to treat infections associated with SCID. Without treatment, most patients do not live beyond one year from birth.
SCID is considered a rare disorder, but the exact incidence of SCID is unknown. Researchers estimate that about 1 out of 1,000,000 people have the disease. Overall, the male-to-female ratio is 3:1 because some forms of SCID are X-linked, while other forms of SCID are autosomal recessive.
Author information
This information has been edited and peer-reviewed by contributors to the Natural Standard Research Collaboration (www.naturalstandard.com).
National Jewish Medical and Research Center. .
National Primary Immunodeficiency Resource Center. .
National Organization for Rare Disorders. .
Natural Standard: The Authority on Integrative Medicine. .
SCID.net. Severe Combined Immunodeficiency. .
: Severe combined immunodeficiency (SCID) is genetically inherited as either an X-linked or autosomal recessive in trait. Each type is caused by a different genetic defect. However, the genetic defect has not been discovered for all forms of the disease.
Autosomal recessive inheritance
: Autosomal (chromosome that is not involved in sex determination) recessive forms of SCID occur when a child inherits two defective copies of the same autosomal gene. Each parent must carry at least one abnormal copy of the gene. If each parent has one defective and one normal gene, there is a 25% chance that each of their children will inherit the disease.
One form of SCID is called adenosine deaminase (ADA) deficiency. This condition results from the lack of an enzyme that helps cells to get rid of toxic byproducts that are created from normal bodily processes like breathing and digestion. Without ADA, toxins accumulate in the body and kill the body's lymphocytes. ADA deficiency has an autosomal recessive inheritance pattern that affects males and females equally.
X-linked inheritance or X-SCID
: X-linked SCID accounts for about 45% of all cases of SCID. This form of the disease is inherited as an X-linked recessive trait. This means the gene that causes the disorder is located on the X chromosome. Women have two X chromosomes, while men have one X chromosome and one Y chromosome. Therefore, this form of the disease affects males almost exclusively. If a male inherits the mutated gene that causes the specific type of SCID, he will develop the disease because he has only one X chromosome.
Females, on the other hand, have two X chromosomes. Even if a female inherits the mutated gene, chances are the other gene will be healthy because the disease is rare. The female would need to inherit two mutated X chromosomes in order to develop the disease. If the female inherits one mutated gene she is a carrier for the disease, and there is a 50% chance she will pass the gene to each of her children. Carriers do not express symptoms of the disease.
: Infants who have severe combined immunodeficiency (SCID) experience an unusual number of bacterial, viral, fungal, and/or protozoan infections that are much more serious and less responsive to medical treatment, such as antibiotics, than would normally be expected because they have weakened immune systems. Patients commonly suffer from pneumonia, meningitis, and/or infections of the blood. Skin problems, including chronic (ongoing) bacterial and fungal infections, may also occur.
Symptoms suggestive of graft-versus-host disease (when the immune cells of a transplant from a donor attack the tissues of the transplant recipient) may appear in newborns up to six weeks old. These symptoms include dermatitis (skin rash), hepatitis (liver inflammation), difficulty breathing (due to stiffening of lungs), diarrhea (sometimes containing blood), jaundice (yellowing of the skin and eyes), and enteritis (inflammation of the intestine). This occurs because the maternal cells that circulate in the baby's blood until he/she reaches six months old cannot be destroyed by the neonate's immune system.
Viral infections
: Exposure to the chicken pox virus, either through a vaccination or in the environment, can be life threatening for SCID patients. Exposure may cause infection of the lungs and brain. The relatively common and harmless cytomegalovirus (a common type of herpes virus) found in the salivary glands of many people can cause fatal pneumonia in children with SCID. Pregnant women with cytomegalovirus can transmit the infection to their fetus. It can also be transmitted through bodily fluids, including breast milk, saliva, blood, urine, semen, and vaginal discharge. Even the herpes simplex virus (that causes the common cold sore) and the measles virus can pose serious health risks in SCID patients. In children without SCID, these diseases are not usually life threatening.
Fungal infections
: Fungal infections, including mouth thrush (Candida albicans) or yeast infections may be less resistant to treatment that would be effective for infants with healthy immune systems.
Pulmonary infections
: Common pulmonary (lung) infections that occur in SCID patients include staphylococci, pneumococcus or hemophilus,
Pneumocystis jiroveci
pneumonia (previously called
Pneumocystis carinii
pneumonia), cytomegalovirus (type of herpes virus), or the measles virus. Symptoms often include a cough without mucous and low levels of oxygen in the blood. These patients may also have chronic (ongoing) inflammation around the bronchial tubes, which are the airway passages that carry oxygen from the mouth to the lungs. There may be no symptoms of this bronchial inflammation, or there may be symptoms such as prominent bronchospasm (involuntary muscle contraction involving the bronchus ), which may cause difficulty breathing. Some patients may have interstitial (spaces within an organ or a tissue) or alveolar (within the air cells of the lungs) pneumonia on both sides. Other symptoms may include may include shortness of breath, cough, fever, chest discomfort, weight loss, chills, spitting up blood (rare), tachypnea (rapid breathing), tachycardia (fast heart rate), mild crackles (bubbling, or rattling sounds that occur when air moves through fluid-filled airways), cyanosis (bluish discoloration of the skin), nasal flaring, and intercostals retractions (visible use of muscles between the ribs that indicates labored breathing).
: Persistent diarrhea is common among SCID patients, and it may be fatal in young children because it can lead to dehydration and prevent the absorption of important nutrients. Diarrhea may also cause severe weight loss. Chronic hepatitis (inflammation of the liver) caused by cytomegalovirus or other bacteria or viruses may also occur. If the liver is affected by this disorder, the bile ducts (small passage that carries bile, a digestive aid, from the liver into the stomach) are likely to be damaged.
Blood abnormalities
: SCID patients often experience abnormalities of the blood, including neutropenia (low levels of white blood cells called neutrophils), red cell aplasia (bone marrow does not produce enough red blood cells), or megaloblastic anemia (anemia with abnormally large red blood cells) that is resistant to the usual medical treatment of vitamin B12 or folic acid. Eosinophilia (high levels of a white blood cell called eosinophils) and monocytosis (high levels of white blood cells called monocytes) may signal an infection like
Pneumocystis jiroveci
pneumonia (previously called
Pneumocystis carinii
pneumonia or PCP).
: Severe combined immunodeficiency (SCID) is generally suspected in infants younger than one year old who suffer from frequent and/or serious infections (especially fungal infections that are resistant to treatment), persistent diarrhea, weight loss, and chronic (ongoing) skin infections. These patients may have an enlarged liver, spleen, and/or lymph nodes, which indicate that the body is fighting off an infection. A series of tests (listed below) are necessary to confirm a diagnosis.
Complete blood count (CBC)
: A complete blood count (CBC) can be conducted to determine the number of lymphocytes in the blood. Lymphocytes are special cells in the bloodstream that support the immune system and keep a patient healthy. The blood count can also show if other immune cells in the blood are absent or out of balance. During the procedure, a small sample of blood is taken and analyzed under the microscope. Decreased levels of lymphocytes may indicate the presence of SCID.
Blood smear
: A blood smear is often used to measure the number of lymphocytes (a kind of white blood cell in the patient's blood). The white blood cells, which are part of the body's immune system, help fight against diseases and infections. Healthy patients typically have more than 1,500 lymphocytes per cubic millimeter of blood. Infants who have SCID usually have significantly decreased numbers of white blood cells.
Mitogen stimulation assay
: Lymphocyte function can be tested by its reaction to specific stimulation with plant extracts called mitogens. Mitogens are added to a sample of the patient's blood to stimulate mitosis (cell division) of lymphocytes. This allows the healthcare provider to observe the lymphocytes during mitosis. This test can detect abnormal or dysfunctional lymphocytes that cause SCID.
Immunoglobulin test
: An immunoglobulin test measures the levels of antibodies (glycoprotein that detects and binds to foreign substances that enter the body) in the blood. Patients who have SCID will have extremely low levels of immunoglobulin, especially two types called immunoglobulin A (IgA) and immunoglobulin (IgM). However, soon after birth, immunoglobulin G (IgG) levels may still be high because the newborn still has healthy maternal IgG that it received through the umbilical cord before birth.
: An X-ray may detect an absent or abnormally small thymus gland, which is associated with SCID. Some T-cells are produced in the thymus gland. If the thymus gland is abnormally small, an insufficient amount of T-cells may be produced causing SCID. An X-ray may also detect inflammation of the lung caused by pulmonary infections like interstitial pneumonitis or pneumonia.
Prenatal testing
: Amniocentesis, chorionic villous sampling, or cord blood can be used to diagnose a fetus with SCID. These procedures are most often conducted in patients who have a family history of SCID. Amniocentesis is performed at about 15-18 weeks of gestation. During the procedure, a long, thin needle is inserted into the pregnant woman's abdominal wall to the uterus. A small amount of fluid is removed from the sac that surrounds the fetus. The fluid is then analyzed for genetic abnormalities. There is a risk of infection or injury to the fetus, and a chance of miscarriage.
During chronionic villus sampling (CVS), a small piece of tissue (chorionic villi) is removed from the uterus during early pregnancy to screen the fetus for genetic defects. Depending on where the placenta is located, CVS can be performed through the cervix (transcervical) or through the abdomen (transabdominal). The risks of infections or fetal damage are slightly higher than the risks of amniocentesis. Fetal loss occurs about two percent of the time.
During a cord blood test, a sample of blood is taken from the umbilical cord at the time of birth. The sample is then analyzed in a laboratory to determine whether the newborn has genetic abnormalities that indicate SCID.
: The only cure for severe combined immunodeficiency (SCID) is a bone marrow transplant. Antibiotics, antifungals, and antivirals are used to treat infections that are commonly associated with SCID. Intravenous immune globulin (IVIG) can help prevent infections. Gene therapy (inserting new, healthy genes into a cell) may be a possible treatment option in the future. However, further research is necessary before it is a standard treatment option for SCID patients.
: Antibiotics, such as erythromycin (ERYC®), azithromycin (Zithromax®), and clarithromycin (Biaxin® Filmtab, Biaxin® Granules, Biaxin® XL Filmtab, or Biaxin® XL Pac), are used to treat bacterial infections that are often associated with SCID.
: Antifungals, such as trimethoprim and sulfamethoxazole (Bactrim® or Septra®), pentamidine (NebuPent®, Pentam®, Pentacarinat®), amphotericin B (Abelcet®), fluconazole (Diflucan®), ketoconazole (Nizoral®), nystatin (Mycostatin®), and atovaquone (Mepron®), are used to treat fungal infections that are commonly associated with SCID.
: Antivirals, such asganciclovir (Cytovene®), foscarnet (Foscavir®) and acyclovir (Zovirax®), are used to treat viral infections that are often associated with SCID.
Bone marrow transplant
: A bone marrow transplant can cure SCID if the patient is diagnosed within the first three months of life. HLA-identical donor bone marrow transplantation is optimal, followed by HLA-mismatched unrelated donor transplantation.
However, not everyone is a candidate for a bone marrow transplant. The transplant must come from a donor whose body tissues are a close biological match to the recipient. Serious health risks are also associated with the procedure, as with any major surgery. Individuals who have weakened immune systems are at risk of developing graft-versus-host disease after surgery. This condition occurs when the transplanted bone marrow attacks the recipient's weakened immune system. Other recipients may experience transplant rejection, which occurs when the body's immune system attacks the donated organ.
In addition, patients who undergo organ transplants must take immunosuppressive medications for the rest of their lives in order to prevent their bodies from attacking the transplanted organs. The most common oral immunosuppressants prescribed in the United States include tacrolimus (Prograf®), mycophenolate mofetil (CellCept®), sirolimus (Rapamune®), prednisone (Prednisone Intensol®), cyclosoporine (Neoral®, Sandimmune®, or Gengraf®), and azathioprine (Imuran®).
HLA-mismatched related donor transplantation is an alternative treatment that is often successful if an HLA-matched donor cannot be identified.
Intravenous immune globulin therapy (IVIG)
: Intravenous immune globulin (IVIG) consists of the antibodies extracted from pooled blood donations from 3,000-10,000 of healthy donors. In some instances, blood from as many as 100,000 donors is used. The beneficial effects of IVIG for the preventative treatment of patients with primary immunodeficiency syndromes are well established. IVIG has been shown to prevent severe lower respiratory tract infections, but not upper respiratory tract and non-respiratory infections in patients with common variable immune deficiency (CVID).
Immune globulin products contain sterile, purified immunoglobulin G (IgG). The products typically contain more than 95% unmodified IgG. The IgG antibodies are the smallest but most abundant antibodies in the body, making up 75-80% of all the antibodies in the body. Most IVIG preparations contain trace amounts of IgA, which can sensitize an IgA-deficient person during long-term treatment. Patients who suffer from severe recurrent viral or bacterial respiratory tract infections or have isolated IgA deficiency (and additional IgG2 and IgG4 deficiency) may develop a severe allergic reaction called anaphylaxis after an IVIG infusion. These patients should receive the first infusion in the hospital under medical supervision.
The immune globulin is typically administered intravenously for about two to four hours a day for two to seven days. The patient usually receives another single dose every 10-21 days, or every three to four weeks depending on the condition. Patients typically start responding to treatment after eight days.
IVIG is available in different concentrations (strengths). The U.S. Food and Drug Administration (FDA) has approved Gammagard S/D®, Gammar-P IV®, Gamimune-N®, Iveegam®, Polygam® S/D, Sandoglobulin® Venoglobulin-I®, Venoglobulin-S®, Carimune/Panglobulin®, Gamunex®, and Baxter AG®.
Gene therapy
: Gene therapy involves inserting genes into an individual's cells and tissues to treat a hereditary (passed down from parents to children) disease. Several gene therapy clinical trials based on gene transfer to hematopoietic cells (blood-forming cells in the bone marrow) have been performed. However, further research is necessary before gene therapy can be recommended. Recently, two fetuses were successfully treated with gene therapy
in utero
with an injection of haploidentical CD34+ cells for a type of SCID called gamma chain deficiency.
Integrative therapies
Blessed thistle
: Laboratory studies report that the herb blessed thistle and chemicals in blessed thistle, such as cnicin and polyacetylene, have activity against several types of bacteria and no effects on other types. Reliable human study is lacking. Further evidence is necessary in this area before a firm conclusion can be drawn.
Avoid if allergic to blessed thistle, mugwort, bitter weed, blanket flower, chrysanthemum, coltsfoot, daisy, dandelion, dwarf sunflower, goldenrod, marigold, prairie sage, ragweed,
, or any plants of the Asteraceae or Compositae families. Avoid in patients with a history of bleeding diseases or gastroesophageal reflux disease (GERD), or if taking drugs for blood disorders, stroke, stomach diseases, or to control stomach acid. Avoid if pregnant or breastfeeding. Stop use two weeks before surgery/dental/diagnostic procedures with bleeding risk and do not use immediately after these procedures.
: Laboratory study suggests antifungal and antibacterial activity of bladderwrack. However, there are no reliable human studies to support its use as an antibacterial or antifungal agent.
Avoid if allergic or hypersensitive to
Fucus vesiculosus
and iodine. Avoid with a history of thyroid disease, bleeding, acne, kidney disease, blood clots, nerve disorders, high blood pressure, stroke, or diabetes. Avoid if pregnant or breastfeeding.
: Study results of cranberry as an antibacterial in other conditions show conflicting results. Further research is needed before a conclusion can be drawn.
Avoid if allergic to cranberries, blueberries or other plants of the
genus. Sweetened cranberry juice can affect blood sugar levels. Use cautiously with a history of kidney stones. Avoid more than the amount usually found in foods if pregnant or breastfeeding.
: Iodine is commonly applied to the skin's surface to clean wounds, sterilize the skin before surgical/invasive procedures, or sterilize the place for catheters before they are put in to collect urine. Betadine solution (topical disinfectant), for example, contains povidone-iodine. Other topical disinfectants include alcohol and antibiotics; iodine is sometimes used in combination with these. Commercially prepared iodine products are recommended in order to assure appropriate concentrations (strengths).
Reactions can be severe and deaths have occurred with exposure to iodine. Avoid iodine-based products if allergic or hypersensitive to iodine. Do no use for more than 14 days. Avoid Lugol solution and saturated solution of potassium iodide (SSKI, PIMA) with medical conditions including hyperkalemia (high amounts of potassium in the blood), pulmonary edema (fluid in the lungs), bronchitis, or tuberculosis. Use cautiously when applying to the skin because it may irritate/burn tissues. Use sodium iodide cautiously with kidney failure. Avoid sodium iodide with blockage of the stomach or large intestine.
: An increasing number of studies support the use of probiotics as a supplement to antibiotic therapy. Probiotic supplementation during a treatment of antibiotics may reduce the side effects of antibiotics in the digestive tract. This includes reducing growth of
Clostridium difficile
bacteria, which can lead to colitis, a common complication of antibiotics, especially in the elderly. Some probiotics may also help prevent the development of antibiotic resistance. In acutely ill children, synbiotics (nutritional supplements containing probiotics and prebiotics) have been linked to greater weight gain and fewer bacterial illnesses after antibiotics are ended. The evidence consistently supports supplementation of antibiotics.
Limited evidence with day care children suggests that supplementation with a type of good bacteria,
GG, may reduce number of sick days, frequency of respiratory tract infections, and frequency of related antibiotic treatments.
Fermented milk (with yogurt cultures and a type of probiotics called
DN-114001) may reduce the duration of winter infections (digestive and respiratory), as well as average body temperature, in elderly people.
There are many different types of potentially disease-causing bacteria in the nose. There is limited evidence that probiotic supplementation may reduce the presence of harmful bacteria in the upper respiratory tract. More studies are needed to establish this relationship and its implications for health.
Results are mixed regarding the ability of probiotics to reduce infective complications of medical treatment. Reduced incidence of infection has been seen in patients treated for brain injury, abdominal surgery, and liver transplantation. Other studies have shown no such reduction in patients who get an infection after elective abdominal surgery and critical care patients.
Probiotics are generally considered safe and well tolerated. Avoid if allergic or hypersensitive to probiotics. Lactose-sensitive people may develop abdominal discomfort from dairy products containing probiotics.
: Animal and laboratory studies suggest that propolis may be able to treat various types of infections. Initial human research reports possible benefits against oral/dental bacteria, genital herpes, urine bacteria, intestinal giardia infections (infection that causes diarrhea), or
Helicobacter pylori
(bacteria that causes a digestive disease). Additional research is needed before a firm conclusion can be made.
Avoid if allergic or hypersensitive to propolis, black poplar (
Populas nigra
), poplar bud, bee stings, bee products, honey, and Balsam of Peru. Severe allergic reactions have been reported. There has been one report of kidney failure with the ingestion of propolis that improved upon discontinuing therapy and deteriorated with re-exposure. Avoid if pregnant or breastfeeding because of the high alcohol content in some products.
: Preliminary research reports that selenium may be beneficial in the prevention of several types of infection, including recurrence of erysipelas (bacterial skin infection associated with lymphedema that causes swelling in the arms and legs) or
pneumonia. Further research is needed to confirm these results.
Avoid if allergic or sensitive to products containing selenium. Avoid with history of nonmelanoma skin cancer. Selenium is generally regarded as safe for pregnant or breastfeeding women. However, animal research reports that large doses of selenium may lead to birth defects.
: There are no well-conducted published studies that demonstrate sorrel to possess activity against viruses or bacteria that are important human pathogens. In an
in vitro
(test tube) study, sorrel did not demonstrate activity against herpes simplex virus-1, herpes simplex virus-2, HIV,
Proteus morganii
Pseudomonas aeruginosa
Serratia marcescens
Staphylococcus aureus
Avoid if allergic or hypersensitive to sorrel or any member of the Rumex acetosa or Polygonaceae plant families. Avoid large doses of sorrel because there have been reports of toxicity and death, possibly caused by oxalate found in sorrel. Fatal oxalic acid poisoning has been reported from sorrel soup. Be aware that many tinctures contain high levels of alcohol and should be avoided when driving or operating heavy machinery. These sorrel formulations may cause nausea or vomiting when taken with the prescription drugs metronidazole (Flagyl®) or disulfiram (Antabuse®). Avoid if pregnant or breastfeeding.
Because severe combined immunodeficiency (SCID) is a genetic disorder, there is currently no known method of prevention. However, individuals can be tested to determine whether they are carriers of the disease.
Preventative treatment against
Pneumocystis jiroveci
pneumonia (previously called
Pneumocystis carinii
pneumonia) is recommended for patients who are older than two months, until their T-cell function returns to normal after a bone marrow transplant. Trimethoprim-Sulfamethoxazole (Bactrim®, Bactrim® DS, Septra®, Septra® DS) is the standard drug of choice. Patients receive intravenous (IV) injections into their bloodstream three times a week.
Copyright © 2011 Natural Standard (
The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.
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text:
Is there such a thing as the Goat Police?
I started making cheese about two years ago when a former coworker introduced me to his newest hobby: homemade feta cheese. I made the feta and realized I no longer needed a grocery store to buy feta cheese. I so love my homemade feta. Sublime.
In turn, I introduced a dear friend to the making of feta and she took it a step further: chevre. Oh my. I can't stop making it. I've been buying my goat milk at the grocery store, but have tried to buy it from local goat farmers. The problem is that they can not sell the milk for human consumption, only baby goat consumption. Baaaa (my whine-aware it's a sheep sound—how does one bleat?). Apparently there are different methods/rules of sanitation for processing to allow for the milk to be sold for humans. Blah, blah. However, I'm really tempted to buy some for "my baby goat" (some kids have imaginary friends, mine just happens to be a goat) and try it. I mean, seriously, in the "olden days" didn't people drink fresh goat milk? What, are the Goat Police going to arrest me? I'd love to hear from some goat "professionals" on this.
Regardless, I adore my goat cheese. Better Half and I eat it plain, with roasted garlic, sprinkled with various herbs and spices, etc. Visit Fias Co Farm for the recipe I use.
Baaa Baaa.


text:
0.CO klah p:: ~w
Hedge Fund Overview
August 2003
Duane Hess CFA Partner ! I
Allan Martin, Senior Consultant
Bryan Schneider, Senior Analyst
''Advancing Your Investments"
One Main Street, Cambridge, Massachusetts 02142-1524
Where do Hedge Funds fit?
• Within a Broad range of "Non-Traditional" strategies
- Private Equity
• Venture, buyouts, restructurings, special situations
• Subordinated (mezzanine) debt
- Hedge Funds
• Merger arbitrage, convertible arbitrage, long/short
- Real Estate
- Natural Resources
• Oil & gas, timber, agriculture
- Managed Futures and Commodities
- "Other"
2 L:Clients:Okfahoma:Research:Asset Class: Hedge Funds
Financial Assets vs. Alternative Assets
Early Stage Venture
Post Venture
Macro & Short Seller
Index ARB Emerging Markets
International Stocks
Domestic Stocks
Expected Vo~atUity High
3 L:Clients:Oklahoma:Research:Asset Class: Hedge Funds
Why bather?
• Managers have a chance to generate higher rates of return
in these more Inefficient Markets
- Fewer market participants
- Absence of timely information
- Dramatic supply/demand imbalances
- Increased opportunity set
- Ability to short securities
4 L:Clients:OkJahoma:Research:Asset Class: Hedge Funds
Challenging Features
• Fees are typically much higher than for traditional mgrs.
- Fee structures have improved over past ten years, and now better
align interests of manager with investors
• Fees often include
- Base fee
- Performance fee
- Clawback provision
• Excess performance fees paid during high return years are returned
("clawed back") to the investor during low return years
5 L:Clients:Oklahoma:Research:Asset Class: Hedge Funds
Ho Alternative AdvisinQ)Differs
Traditional Assets Alternative Assets
Traditional tools (mean-variance optimization) and The lack of readily available and reliable data makes
Creating Program reliable inputs (historical data is readily available) allow modeling difficult and requires different, more time-for
easy oroaram modelina and construction consumina methods of oroaram construction.
Performance Data is readily available from manager and
Performance data is NOT readily available and indexes
Evaluating Performance useful indexes have been constructed to assist with
are either non-existent or not especially useful which
makes modeling and benchmarking much more difficult
modeling and benchmarking and time consuminq
Alternative managers have vast differences in their limited
Evaluating Legal Documents Most traditional manager documents are fairly boiler-plate partnership or other legal agreements with their investors;
and routine, with few differences between managers certain provisions can severely negatively impact
investors who fail to understand the legal agreement
Alternative Managers require significant back office
structures, employee compensation and retention
Traditional Managers have understandable and tested packages, client services and sound investment
Evaluating Organizational Structure structures in place to deal with all phases of their processes; though some firms can succeed while being
business from deal execution to marketing deficient in a few areas, few can thrive while being
deficient in all; Evaluating all these aspects is time
consuminq and costly
Alternative Managers' products may be available to the
public for only brief windows of time; and sometimes, they
Traditional Managers' products stay on the market will not accept new investors at all (meaning they open
Evaluating Available Products (though some Small Cap managers may close to new their funds only to existing investors); knowing who is or
investors periodically) for indefinite periods of time who soon shall be in the market is critical in terms of
knowing against whom evaluations of products should be
Evaluating Traditional Managers has become more Alternative Managers have traditionally catered to high net
routinized over the years with many managers adhering worth investors and have not yet fully adapted to
Due Diligence Required to AIMR PPS which allow more meaningful performance institutional needs in terms of procurement; further, few
comparisons; and such managers have simultaneously
adapted their RFP procedures to be more amenable to
have adopted AIMR PPS which makes performance
institutional investors
evaluation more difficult and time-consuming
Performance data is neither transparent nor readily
Monitoring Performance Data is transparent and readily available available; additionally, there is a lag in peformance data
and permits monitoring ease which makes monitoring more time consuming and
~ 6 LCfients:Oklahoma:Research:Asset Class: Hedge Funds
Hedge Fund Overview
• What are Hedge Funds?
- Private investment vehicles
• Usually a limited partnership format
• Can be domiciled in the U.S. or offshore
• Usually (but not always) involves leverage
• Usually (but not always) involves short selling
• Why do we like Hedge Funds?
- Attractive Returns
- Diversification Benefits
• What concerns us about Hedge Funds?
- Investment Risk (reality)
- Career Risk (perception)
7 L:Clients:Oklahoma:Research:Asset Class: Hedge Funds
Hedge Fund Overview
Hedge Fund Style
I Relative Value I I Event-Driven I l Opportunistic 1
- Equity Market Neutral f0- Risk Arbitrage r- Macro
- Convertible Arbitrage '-- Distressed Securities - Short Sellers
- Fixed Income Arbitrage - Long Region,
Industry, or Style
- Emerging Markets
- Long/Short Equity
Low .~------------- Market Exposure ------ .~.• High
8 L:Clients:Oklahoma:Research:Asset Class: Hedge Funds
Hedge Funds - Correlation to S&P 500
Annual Correlation to S&P 500 by Hedge Fund
Style Indices
(through 12/31/02)
1 Year 3 Years 5 Years 7 Years
Hedge Fund lndex ' 0.83 0.62 0.65 0.69
Market Neutral1 (0.48) (0.26) (0.14 ) 0.02
Event Driven" 0.51 0.49 0.52 0.54
Merger Arbitrage 1 0.62 0.41 0.56 0.55
Convertible Arbitrage 1 0.27 0.29 0.32 0.30
Macro Index2 (0.35) (0.02) 0.24 0.36
Equity Hedge (Long/Short)2 0.80 0.61 0.71 0.68
Fund of Funds2 0.47 0.38 0.47 0.53
1 Data from the Hennessee Hedge Index
2 Data from the HFRI Data Base
9 LClients:Oklahoma:Research:Asset Class; Hedge Funds
Relative Value Event Driven opportunistic
.................................................................................................................................................................................................................................................................................................................... c-- . .
- -
........................ ~
qJs.~ ...............'0..s.....................................
s~ 'V
Source: Hedge Fund Research, Inc., January 1990 - March 2000; Returns reflect the average for the strategy;
individual funds variability will be greater
LClients:OkJahoma:Research:Asset Class: Hedge Funds
Hedge Fund Overview
• Benefits
- Potentially high returns
• Depends on strategy
• Wide difference from manager to manager
- Potentially low correlations
• Depends on strategy
• Wide difference from manager to manager
11 L:Cfients:OkJahoma:Rese(¥ch:Asset Class: Hedge Funds
Hedge Fund Overview
• Challenges
- Potentially opaque
• Many hedge fund managers refuse to divulge
- Holdings
- Transactions
- Portfolio characteristics
- Investment methodology
• Can be difficult to value
- Some strategies use lots of derivatives
- Some strategies use very illiquid securities
- Very difficult to monitor
• Often unregulated
• Instances of fraud
12 L:Cfients:Oklahoma:Research:Asset Class: Hedge Funds
Hedge Fund Overview
• The Transparency Issue
Many (but not all) hedge fund managers resist providing necessary
levels of transparency
• However, the number of transparent funds is growing
• Institutions are increasingly successful in demanding transparency
- But what is transparency?
• The ability to evaluate the manager
• The ability to evaluate the strategy
• The ability to evaluate portfolio exposures
- Transparency does not need to involve
• Automatic distribution of manager information
• Freely disseminating sensitive information
13 LClients:Oklahoma:Research:Asset Class: Hedge Funds
Hedge Fund Overview
• The Transparency Issue
- A legitimate fear from hedge fund managers is that competitors will
see their portfolio
• A reasonable concern for portfolios with short positions
• However, this can be mitigated by having clients sign Non-Disclosure
- Unfortunately, this concern still does not obviate a fiduciary's need for
unbiased information regarding their portfolio
14 L:Clien(s:Oklahoma:Research:Asset Class: Hedge Funds
Hedge Fund Overview
• The Transparency Tradeoff
- If investors rigidly demand full transparency
• There will be fewer managers to invest with
• The opportunity set might not yield as good performance
- If investors ignore the transparency issue, they risk
• Something blowing up in their face
• Explaining to outsiders (e.g. reporters) why the hedge fund manager
wouldn't disclose information
• Personal liability
- A balance needs to be struck, and both the hedge fund manager and
plan sponsor communities needs to adjust in order to make
alternatives work
15 L:Clients:Oklahoma:Research:Asset Class: Hedge Funds
Hedge Fund Overview
• The Leverage Issue
- Leverage is the ultimate two-edge sword
• Can help boost return, but only by boosting risk
• Magnifies the potential outcomes
- Leverage means different things to different people
• Our concern is the cumulative exposure that an invested dollar generates
• Other measures involve looking at borrowing (if present), or long minus
short positions
- In general, NEPC is uncomfortable with
• Net leverage (longs - shorts) over 100%
• Gross leverage (longs only) over 200%
- If a manager's return comes predominantly from leverage, NEPC
would recommend against it
16 L:Cfients:Oklahoma:Research:Asset Class: Hedge Funds
Hedge Fund Overview
• The Leverage Issue - an Example
If you invest in a manager that sells short, you could get up to $3
invested for every dollar you commit
• Here's how
- The dollar pledged to the manager is invested long
- The long position is used for collateral for a short sale
- The proceeds from the short sale are then invested elsewhere
(usually cash, but can also be stock futures, etc.)
• This example does not involve borrowing or using derivatives
Many (but not all) managers make use of borrowing, as well
• Here's how
- The manager borrows money to invest alongside your assets (a
margin account)
- Depending on the arrangements, managers can borrow multiples of
their collateral
17 LClients:OkJahoma:Research:Asset Class: Hedge Funds
Hedge Fund Overview
• The Leverage Issue
- Derivatives (futures, options, swaps, structured notes, etc.)
• Can allow managers to obtain considerable market exposure by investing
only a fraction of the assets
• The good news is that this can offer the manager a cheap and easy way
to get market exposure
• The bad news is that it can allow managers to have market exposure far
greater than their collateral (think of Long-Term Capital)
- Derivatives use is very difficult to monitor and evaluate (again, think
of Long-Term Capital)
- In general, NEPC has shied away from derivatives-based hedge fund
• These tend to be the strategies that "blow up"
18 L:Clients:Oklahoma:Research:Asset Class: Hedge Funds
Hedge Fund Overview
• Hedge strategies that NEPC has recommended
- Long/short
- Event Driven/Merger Arbitrage
- Convertible Arbitrage
- Market Neutral
- Fund-of-Funds
• NEPC has NOT recommended strategies with
- Excessive leverage
- Lack of transparency
- Short or inconsistent track records
- Unproven strategies
19 L:Clien(s:Oklahoma:Research:Asset Class: Hedge Funds
• Hedge funds are growing rapidly
- NEPC suggests investments in strategies with
• Reasonably long, proven track records
• Stable organizations with qualified, reputable professionals
• In asset classes that have at least some existing institutional participation
• In strategies that best complement existing asset classes
• In ways that are consistent with industry best practices and all applicable
laws and regulations
20 L:Clients:Oklahoma:Research:Asset Class: Hedge Funds
JUN fl1 1011
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text:
Notre Dame enjoys the support of a distinguished Board of Trustees, council group, and deans. These individuals collaborate to provide excellent leadership for the University. This partnership will be more important than ever in the years just ahead, as we strive to achieve our goal of making Notre Dame a preeminent research university with a distinctive Catholic character and an unsurpassed commitment to undergraduate education.
Rev. John I. Jenkins, C.S.C.
Elected in 2005 as the University of Notre Dame's 17th president, Rev. John I. Jenkins, C.S.C., has devoted himself to fostering the University's unique place in academia, the Church, our nation, and the world. A philosopher trained in theology and a member of Notre Dame's Department of Philosophy since 1990, Fr. Jenkins earned undergraduate and advanced degrees from Notre Dame, a doctorate of philosophy from Oxford University, and a master of divinity and licentiate in sacred theology from the Jesuit School of Theology.
As president, Fr. Jenkins has been committed to combining teaching and research excellence with a cultivation of the deeper purposes of Catholic higher education. While pursuing academic distinction, he has brought renewed emphasis to Notre Dame's distinctive mission, rooted in the tradition of the Congregation of Holy Cross, the University's founding community, to educate the whole person—mind, body, and spirit—to do good in the world.
If we are clear in our purpose, we will excel in our ideals. This will be my priority and my passion as president of Notre Dame.
Inaugural Speech, 2005
Thomas G. Burish
Charles and Jill Fischer Provost
Thomas G. Burish was elected the fourth provost of the University of Notre Dame on July 21, 2005. Dr. Burish served as president of Washington and Lee University from 2002 to 2005 and was Vanderbilt University's provost from 1993 to 2002. After his graduation from Notre Dame in 1972, Dr. Burish received master's and doctoral degrees in psychology and clinical psychology from the University of Kansas.
The challenge of wrapping together our faith-based heritage while further strengthening our academic excellence is a rare opportunity and, for me, a special dream.
Appointment Acceptance, 2005
John F. Affleck-Graves
Executive Vice President
John F. Affleck-Graves was elected executive vice president April 30, 2004, by the Board of Trustees. Dr. Affleck-Graves holds the Notre Dame Chair in Finance and served for three years as vice president and associate provost. He earned his bachelor's, master's, and doctoral degrees at the University of Cape Town, where he taught from 1975 to 1986.
Through sound financial stewardship, visionary leadership, and continued commitment to core values, Notre Dame is poised to become the preeminent faith-based research university of the 21st century.
University Annual Report, 2006
The University of Notre Dame is governed by a two-tiered structure (Fellows of the University and the Board of Trustees), in which lay men and women have joined with religious of the Indiana Province of Holy Cross in the governance of the University. The Fellows of the University are a "self-perpetuating body," consisting of six members who at all times must be "members of the Priests Society of the Congregation of Holy Cross, Indiana Province, and six of whom shall be lay persons." The Fellows are the associates in office of the original founders of the University and, among other responsibilities, determine powers to be delegated to the Board of Trustees.
Read more about the responsibilities of both the Fellows and Board of Trustees.


text:
SARATOGA SPRINGS, N.Y. – With three goals in the first 12 minutes of the second period, Skidmore College was able to edge men's hockey by the final score of 3-2 Saturday evening in the first round of the ECAC East tournament.
Saturday's win advances the fourth seeded Thoroughbreds (12-12-2) to next week's semi-final round where they will face top-seeded Norwich University. Norwich will host both semi-final games on Friday and the championship game on Saturday. The Beacons closed out the 2011-12 season with an overall record 13-10-3.
UMass Boston would strike first in Saturday's first-round game with John Hubbard (Arlington, Texas) scoring his first goal of the season just four minutes into the period. Assisting on the play was Anthony Fitti (Havertown, Pa.) and Mike DeGrazia (Novi, Mich.). The Beacons would maintain the one goal lead and would outshoot Skidmore 15-9.
After the first intermission, Skidmore quickly tied the game at 1-1 just 64 seconds into the second frame. Eight minutes later, the Thoroughbreds took their first lead of the night on the power-play with a Phil Buonocore score. Just moments later Skidmore made it a two-goal game, once again on the power-play with the eventual game-winning score going to Chris Powers.
Now down by two the Beacons needed to get back into the game as soon as possible. Less than two minutes after falling into the score hole, Tim Richter (Naugatuck, Conn.) made it just a one-goal game on his even strength tally.
The period would end with both teams even in the shots column as they each got off a combined 13 shots each. In the final frame there was just one penalty called over the course of the final 20 minutes of play. Skidmore would hold onto their lead and led the period with an 8-7 advantage in shots.
Between the pipes Kevin Bendel (Denville, N.J.) posted 27 saves, while his Skidmore counterpart Colin Bessey made 33 saves to improve to 11-10-0 on the year. On the power-play the Thoroughbreds finished the night 2-for-4, while UMass was 0-for-3 on the man-up chances.
Saturday's contest marked the final game in the college careers of nine senior members in Bendel, Fitti, Hubbard, Bill Baker (Vancouver, B.C.), Bryan Albert (Redlands, Calif.), Kyle Tejchma (Fruitport, Mich.), Chris Wyman (Bartlett, Ill.), Jim Ennis (Roslindale, Mass.), and Andrew Burke (Southampton, Pa.). Despite the loss the Beacons can skate away from this season know that it was perhaps one of the most memorable years in the programs history as they toppled two top-5 teams, which included handing the first-seeded Cadets of Norwich University their first loss of the season.


text:
Tim Howard to retire after current deal
Tim Howard's new contract will be his last.
The longtime U.S. national team goalkeeper, who last week signed a two-year extension with Everton that will take him past his 39th birthday, says there is no chance he will play professionally into his forties -- despite Toffees manager Roberto Martinez's belief that he is capable.
"He is a fit man and at the peak of his powers," Martinez said when the deal, which runs through the 2017-18 English Premier League season, was announced on April 17. "I know he will play on beyond 40."
Not so, according to Howard.
"I'll be on a beach somewhere when I'm 40," Howard told ESPNFC.com in a phone interview on Friday. "I would pretty much take that to the bank that I won't be playing past 40. There are other things I want to achieve in life, other things that I want to do."
Howard has spoken often about his desire to move into a front office role -- either in England or in MLS -- after his playing days are over. Television work could be another option; he's already provided color commentary on several of NBC's Premier League broadcasts this season.
But Howard has also expressed a desire to finish his career where it started. He left MLS in 2003 when he was transferred from the MetroStars -- now the New York Red Bulls -- to Manchester United. His new pact with Everton all but ended those ambitions.
"Up until last week it was a possibility," Howard said. "But I think that ship has sailed for me now. I think MLS had its chance, if I'm being honest, but now I'll finish my career with Everton and be a happy man."
Howard is expected to man the U.S. nets at his third World Cup this summer in Brazil. He originally joined Everton in 2006 on loan from United, securing a permanent transfer the following year.
His first seven years at Everton were spent under manager David Moyes.
Moyes, who replaced the legendary Sir Alex Ferguson at Manchester United before this season, was fired on Tuesday, two days after losing to his former team at Goodison Park. The win kept Everton in the hunt for a Champions League spot, but Howard admitted to mixed emotions after learning Moyes had been sacked.
"I was disappointed because I love the man," Howard said. "He was brilliant to me and for me. He was brilliant for the club that I love, so you feel for him.
"I think there's a lot of things that need fixing at Manchester United apart from David Moyes, but in this business you also realize the head coach is always going to be the first to go, unfortunately. But he'll survive, he'll move on, and I think he'll be brilliant. We'll all see that in due time."
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text:
BostonUrbEx wrote:But what do you do with the platform for the Danvers/Peabody Branch? Eliminate the parking area on the inside of the curve and put it there? Seems to be the only way that fits. But then trains/gates will block the entrance road to get into the area and to the garage.
The MBTA offered a contract to a Milford-based company this week to oversee the construction of Salem's new train station and parking garage.
Consigli Construction Company will be paid up to $32.5 million and will be in charge of subcontracting with builders to complete the project.
This was the final go-ahead on a project that's been decades in the making.
The $44.5 million station project will include a new five-level parking facility holding approximately 700 vehicles and facilitate future Transit-Oriented Development opportunities on nearby MBTA and City of Salem sites. The MBTA has made a commitment to the City to open the new garage by October 1, 2014.
The project will provide a fully accessible intermodal Commuter Rail Station along with a new garage with accessible parking on all five levels and electric car parking, Zip Car parking, motorcycle parking, and bicycle parking.
The new station and parking facility will support higher-frequency MBTA Commuter Rail service. The Salem Station is currently the second busiest on the Commuter Rail system with 2,400 boardings per day. The project design promotes future Transit-Oriented Development opportunities by providing for future development on the nearby City of Salem site and over the bus and vehicle driveways to the riverfront.
Elcamo wrote:Traffic between Peabody/Danvers and Salem is just going to get that much worse with the inclusion of a new garage, the T better be fully prepared to do CR out there in the next 10-15 years, or that end of 114 is going to become a parking lot during rush hour.
Wasn't/isn't there still an option to add a second track at a later date if the T decided to?/Is there enough room to excavate space for another track and platform without affecting the condo complex parking lot? From looking at Google Maps it doesn't appear so unless the existing track were to get shifted a bit more to the west.F-line to Dudley via Park wrote:Except it doesn't increase schedule capacity much at all beyond the modestly easier level boarding dwell times because they shot their whole wad on that white elephant parking garage instead of adding a second outbound platform outside the portal and making train meets stageable at both ends of the tunnel instead of way the hell back at Beverly. That's going to bite them in the butt in a few years.
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