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Early Years
Smith was born in Lincolnshire, England, the son of George Smith, a farmer, and Alice Rickard Smith. The eldest of five boys and a girl, he was baptized at Saint Helen's Church in Willoughby, Lincolnshire, on January 9, 1580. John Smith may have been a student of the Puritan reformer Francis Marbury (father of Anne Hutchinson) before attending the King Edward VI Grammar School in Louth. In 1595 Smith was apprenticed to the wealthy merchant Thomas Sendall in King's Lynn. This seems to have been an amicable arrangement, but after Smith's father died in April 1596 and his mother remarried, Smith terminated his apprenticeship and left England.
Looking to travel, he served as a soldier in the Low Countries under Captain Joseph Duxbury until about 1599; he then joined a company of English volunteers as an attendant to Peregrine Bertie, thirteenth baron Willoughby of Eresby, and traveled to France as part of forces allied with Henri IV, the Huguenot (Protestant) claimant to the throne. After returning to England, Smith became acquainted with an Italian nobleman of Greek descent who taught Smith much about horsemanship. Late in 1600, he returned to mainland Europe, traveling to the south of France and then through the eastern Mediterranean on a merchant ship whose captain had a penchant for piracy. After an encounter with a large Venetian merchant ship, Smith landed in Italy with a share of prize money.
Smith Travels to Virginia
On December 20, 1606, three ships carrying 104 settlers set sail for Virginia from London. Christopher Newport captained the Susan Constant, Gosnold the Godspeed, and John Ratcliffe the Discovery. Smith, aboard Newport's flagship, was arrested en route on February 13, 1607, accused of, in his own words, plotting to "usurpe the governement, murder the Councell, and make himselfe kinge." By Smith's reckoning, the gentlemen he traveled with were envious of his military experience and seamanship, and if they looked down on his yeoman upbringing, then he looked up at them in contempt. He was kept in irons throughout the rest of the transatlantic crossing and when the fleet reached Nevis, in the West Indies, on March 28, 1607, Newport ordered a gallows erected. Only the intercessions of Gosnold and a chaplain prevented Smith's execution.
The new colony was to be governed on the ground by a seven-man council whose members had been chosen by the Virginia Council in London prior to the settlers' departure. The company insisted on placing the names of those chosen in a sealed box, which was to be opened when the colonists reached their destination. After dropping anchor in the Chesapeake on April 26, Newport opened the box only to find that the hated Smith was among the chosen councilors. Wingfield, who was elected president of the colony, refused to administer the oath of office to Smith. He was not admitted to the council until June 10.
Exploring the Chesapeake
On September 10, 1607, Smith, Ratcliffe, and John Martin voted to remove Wingfield from office, with Ratcliffe taking over as colony president. Ratcliffe appointed Smith cape merchant, making him responsible for, among other things, trading with the region's Indians. It was this role that would shape Smith's perspective on the new world. Smith had already undertaken three exploratory voyages of the Chesapeake in June, July, and August of 1607; in December, he and two other men ventured up the Chickahominy River, where they encountered a hunting party of Pamunkey Indians. His companions were killed, but Smith, whom the Indians initially presumed to be a weroance, or chief, was captured. The Indians escorted him up the York River to Werowocomoco, the principal residence of their mamanotowick, or paramount chief, Powhatan (Wahunsonacock).
At Werowocomoco, Smith participated in a ceremony that many historians now interpret as an adoption ritual. Exactly what happened during this ceremony is unclear; Smith himself gave varying accounts of the event. In his Generall Historie , published in 1624, Smith wrote that "two great stones were brought before Powhatan: then as many as could laid hands on him, dragged him to them, and thereon laid his head, and being ready with their clubs, to beat out his brains … Pocahontas the King's dearest daughter, when no entreaty would prevail, got his head in her arms, and laid her own upon his to save him from death." But in a letter written just a few months after his visit to Werowocomoco, he describes being feasted and interviewed by Powhatan only. Some historians argue that this earlier, less dramatic version of events is the more likely; the anthropologist Helen C. Rountree suggests that Pocahontas, about eleven at the time, may not even have been present at the ceremony; her role as a young girl was to prepare for and clean up after the feast.
Two days later, Smith was taken to a remote location in the woods. There, Powhatan told him (in Smith's words) that "now they were friends," and ordered him to send two "great gunnes [cannon], and a grindstone" from Jamestown; in exchange, Powhatan would give him the Indian village Capahosic and hold him in esteem as his son, bestowing upon him the name Nantaquoud. Smith may not have fully understood that Powhatan was trying to draw him (and, therefore, the other colonists) into his paramount chiefdom, thereby neutralizing a threat, gaining an ally, and expanding his empire—but he was aware that the savvy leader was trying to gain control of some very powerful weapons.
Smith returned to Jamestown on January 2, 1608, to find that he had been replaced on the council and blamed for the deaths of his two companions. That day he was tried, convicted, and sentenced to hang—but later that night, Newport and some one hundred new settlers arrived from England, and the charges against Smith were lost in the celebration.
The Smith Presidency
On September 10, 1608, Smith became president of the council at Jamestown. He immediately set about rebuilding and strengthening the colony's defenses. His efforts included enlarging the triangular fort into a five-sided structure and requiring all colonists to work to support the settlement: "the labours of thirtie or fortie honest and industrious men shall not be consumed to maintaine a hundred and fiftie idle loyterers." Smith forced them to grow crops, catch fish, and perform military drills, declaring, "He that will not work shall not eat." He later claimed that as a result of his policies thirty or forty acres of ground were planted, a well of sweet water was dug in the fort, and some twenty houses, a blockhouse, and a separate fort were constructed. He also said that the number of livestock increased under his watch. But his policies were unpopular, and the colonists still failed to produce an adequate supply of food, leaving them dependent on Indian trade.
In October 1608, Newport returned from England with the so-called Second Supply of settlers and instructions from the company to improve Indian relations by staging a "coronation" of Powhatan. In Newport's mind, the ceremony would acknowledge the paramount chief's status among his people, but also indicate his submission to King James's rule. Smith was convinced that Powhatan would misinterpret the ceremony: as an emperor in his own right, he would assume that the English were confirming his leadership, not subordinating him.
In June 1609 the Virginia Company of London instituted a new, more centralized government and dispatched a fleet of nine ships carrying a resupply of some 400 settlers, including the colony's new governor, Sir Thomas Gates. But the ship that carried him, the Sea Venture , was separated from the fleet by a hurricane, its passengers marooned in the Bermudas. When Gates failed to arrive, Smith refused to step down as president, throwing Jamestown into a political tailspin. Late in the summer, hoping to alleviate the strain on the settlement's slim resources (and perhaps rid himself of his adversaries), Smith sent two groups of men to live off the land. He sent the first group, headed by Captain Francis West, to the falls of the James to occupy the Indian village at Powhatan, and the second, led by Percy and Martin, to Nansemond. Such an aggressive move exacerbated the existing hostility between the Indians and the English, and both West's and Percy's groups lost about half their men—about 100 in all—in skirmishes with the local tribes. The fighting heralded the beginning of the First Anglo-Powhatan War, which only ended in 1614, when Pocahontas married the Englishman John Rolfe.
By this point, Smith had drawn the ire of many of Jamestown's leading figures: West, Percy, Martin, Ratcliffe, and Gabriel Archer. In September 1609, while traveling down the James, a stray match ignited Smith's powder bag and caused an explosion that set his clothing ablaze. He was badly burned, and though he later claimed that the match fell "accidentallie," the historian James Horn writes, "The terrible injury was no accident but a deliberate attempt to kill him, this time by the English." His rivals deposed him and sent him back to England, and Percy became president of the colony.
Later Years
In 1631, Smith became mortally ill. He prepared his will on June 21 and died later that day. He was buried in London in Saint Sepulchre's Church.
Indeed, Smith was an accomplished braggart who credited himself with the Jamestown colony's survival. In his work he often refers to himself in the third person, as if to imply that the praise is coming from a different source. As the historian Alden T. Vaughan has suggested, it's possible that even Smith's contemporaries did not believe his accounts: Thomas Fuller wrote in a biographical dictionary called The Worthies of England (1661) that "we have two witnesses to attest [to Smith's experiences], the prose and the pictures, both in his own book; and it soundeth much to the diminution of his deeds, that he alone is the herald to publish and proclaim them." The Legend of Captain Jones (1631), a satirical poem taking aim at Smith's autobiography, was so popular that six editions were printed within forty years of its publication. In the nineteenth and early twentieth centuries, several scholars worked to discredit Smith's accounts of his life prior to the Jamestown voyage. But in 1986, the historian Philip L. Barbour released The Complete Works of Captain John Smith, and his painstaking annotations reveal that there is evidence (some of it circumstantial) to back up many of Smith's claims.
Major Works
- A True Relation (1608)
- A Map of Virginia. With a Description of the Countrey, the Commodities, People, Government, and Religion (1612)
- The Proceedings of the English Colonie in Virginia (1612)
- A Description of New England (1616)
- New Englands Trials (1620)
- The Generall Historie of Virginia, New-England, and the Summer Isles (1624)
- A Sea Grammar (1627)
- The True Travels, Adventures, and Observations of Captaine John Smith (1630)
- Advertisements For the unexperienced Planters of New-England (1631)
Time Line
January 9, 1580 - John Smith, the son of farmer George Smith and his wife, Alice Rickard Smith, is baptized at Saint Helen's Church in Willoughby, Lincolnshire, England.
1595 - John Smith is apprenticed to the wealthy merchant Thomas Sendall in King's Lynn, England.
1596–1599 - Having terminated his apprenticeship, John Smith serves in the Low Countries under Captain Joseph Duxbury.
April 1596 - George Smith dies. His oldest son, John Smith, inherits half of his estate, including seven acres in Charleton Magne.
1599 - John Smith travels to France with Peregrine Bertie, thirteenth baron Willoughby of Eresby.
Late 1600 - John Smith joins the Habsburg armies, allied with Transylvanian forces, to fight the Turks in Hungary.
1601 - John Smith, fighting with a Hungarian regiment, is promoted to captain of cavalry.
1602–1603 - John Smith kills three Turkish challengers in hand-to-hand combat. In November, he is wounded and captured in a skirmish with Tatar allies of the Turks, and sold into slavery. Smith's owner, a young woman, sends him to her brother, the head of a government fief near the Black Sea. Smith kills him and escapes.
1604–1605 - John Smith returns to England, where he meets Bartholomew Gosnold, who is promoting a plan to plant an English colony in Virginia.
April 10, 1606 - King James I grants the Virginia Company a royal charter dividing the North American coast between two companies, the Virginia Company of London and the Virginia Company of Plymouth, overseen by the "Counsell of Virginia," whose thirteen members are appointed by the king.
December 20, 1606 - Three ships carrying 104 settlers sail from London bound for Virginia. Christopher Newport captains the Susan Constant, Bartholomew Gosnold the Godspeed, and John Ratcliffe the Discovery.
February 13, 1607 - John Smith, aboard the Susan Constant and bound for Virginia, is arrested and accused of plotting to "usurpe the governement, murder the Councell, and make himselfe kinge."
March 1607 - In the West Indies, colonists on the three Virginia-bound ships under the command of Captain Christopher Newport go ashore to hunt, fish, and rest. Newport builds gallows to hang John Smith, but Smith is spared when Bartholomew Gosnold and the Reverend Robert Hunt intercede on his behalf.
April 26, 1607 - Jamestown colonists first drop anchor in the Chesapeake Bay, and after a brief skirmish with local Indians, begin to explore the James River.
May 13, 1607 - The Jamestown colonists select a marshy peninsula fifty miles up the James River on which to establish their settlement.
May 21–27, 1607 - Captain Christopher Newport, Captain John Smith, George Percy, and others explore the James River, making mostly friendly contact with the Kecoughtans, the Paspaheghs, the Quiyoughcohannocks, and the Appamattucks.
May 28, 1607 - After an Indian attack, the settlers at Jamestown begin building a fort.
June 10, 1607 - Finally released from arrest, John Smith takes his seat as a member of the Council.
June 15, 1607 - English colonists complete construction of James Fort at Jamestown.
September 10, 1607 - Council members John Ratcliffe, John Smith, and John Martin oust Edward Maria Wingfield as president, replacing him with Ratcliffe. By the end of the month, half of Jamestown's 104 men and boys are dead, mostly from sickness.
September 19, 1607 - John Ratcliffe, president of Jamestown, designates John Smith the colony's cape merchant.
November 9–15, 1607 - John Smith makes three successful trading voyages up the Chickahominy River.
December 1607 - Late in the month, John Smith is brought before Powhatan, the paramount chief of Tsenacomoco. He later tells of his life being saved by Pocahontas; in fact, Powhatan likely puts Smith through a mock execution in order to adopt him as a weroance, or chief.
December 1607 - While exploring the upper reaches of the Chickahominy River, John Smith is captured by a communal hunting party under the leadership of Opechancanough.
January 2, 1608 - John Smith returns to Jamestown after being held captive by Powhatan. Only thirty-eight colonists survive, Smith's seat on the Council is occupied by Gabriel Archer, and the Council accuses Smith of killing his companions. Smith is sentenced to hang, but the charge is dropped when Christopher Newport arrives with the first supplies from England.
February 1608 - Christopher Newport and John Smith visit Powhatan, the paramount chief of Tsenacomoco, at his capital, Werowocomoco. Powhatan feeds them and their party lavishly, and Newport presents the chief with a suit of clothing, a hat, and a greyhound. The English continue upriver to visit Opechancanough at the latter's request.
June 1608 - John Smith sends with Captain Francis Nelson a long letter he has written to a friend in England, describing the events of the last two years, and a map of the region. The letter and the map (later known as the Zúñiga map) are published in London as A True Relation.
June–September 1608 - John Smith explores the Chesapeake Bay without Powhatan's permission.
June 2, 1608 - John Smith and fourteen men embark from Jamestown on the first of two major Chesapeake Bay explorations. They visit the Eastern Shore and the falls of the Potomac River.
July 21, 1608 - John Smith and his party return to Jamestown after the first of two major Chesapeake Bay explorations.
July 24, 1608 - John Smith embarks on the second of his two major Chesapeake Bay explorations. He and his party explore the Susquehanna, Patuxent, and Rappahannock rivers and negotiate peace between the Rappahannock and Moraughtacund Indians.
September 7, 1608 - John Smith and his party return to Jamestown after the second of his two major Chesapeake Bay explorations.
September 1608 - Christopher Newport returns from England with a plan to improve relations with Virginia Indians by bestowing on Powhatan various gifts and formally presenting him with a decorated crown. The subsequent crowning is made awkward by Powhatan's refusal to kneel, and relations sour.
December 1608 - Christopher Newport returns to England from Jamestown accompanied by the Indian Machumps. John Smith, meanwhile, attempts to trade for food with Indians from the Nansemonds to the Appamattucks, but on Powhatan's orders they refuse.
January 1609 - John Smith meets with Powhatan, the paramount chief of Tsenacomoco, at his capital, Werowocomoco. Against Indian custom, Smith refuses to disarm in Powhatan's presence, and the chief attempts, but fails, to have Smith killed.
May 1609 - With the Jamestown population at about 200, John Smith sends a third of the men downriver on the James to live off oysters. Twenty go with George Percy to Point Comfort to fish, and another twenty go with Francis West to live at the falls of the James. The rest stay at Jamestown.
May 23, 1609 - The Crown approves a second royal charter for the Virginia Company of London. It replaces the royal council with private corporate control, extends the colony's boundaries to the Pacific Ocean, and installs a governor, Sir Thomas West, twelfth baron De La Warr, to run operations in Virginia.
Summer 1609 - John Smith unsuccessfully attempts to purchase from Powhatan, the paramount chief of Tsenacomoco, the fortified town of Powhatan in order to settle English colonists there.
Early September 1609 - John Smith sends Francis West and 120 men to the falls of the James River. George Percy and 60 men attempt to bargain with the Nansemond Indians for an island. Two messengers are killed and the English burn the Nansemonds' town and their crops.
September 1609 - John Smith is severely burned during a trip down the James River when a stray match ignites his powder bag and sets his clothing ablaze.
October 1609 - John Smith leaves Virginia. The Jamestown colony's new leadership is less competent, and the Starving Time follows that winter.
Late November 1609 - John Smith arrives in England from Jamestown.
1612 - Two works by John Smith, A Map of Virginia with a Description of the Countrey and The Proceedings of the English Colonie in Virginia, are published in Oxford, England.
March 1614 - John Smith sails for "North Virginia," a region he later names New England. After returning to England with furs and fish, he is authorized by the Virginia Company of Plymouth to plant a colony in New England.
March 1615 - John Smith sails to New England to establish a colony, but returns to England after losing a ship in a storm en route.
June 1615 - John Smith sails for New England again, but is captured by a French privateer. He returns to England in December.
June 1616 - John Smith publishes his work A Description of New England.
Late 1616 - John Smith visits Pocahontas in England and she chides him for neglecting their friendship.
1617 - John Smith attempts yet again to sail for New England, and is again thwarted.
1620 - John Smith's New Englands Trials is published.
1621 - John Smith asks the Virginia Company of London to reward him for his service during his time in Jamestown, but they refuse to do so. They also refuse to employ him as a military commander.
May 1623 - In response to the reports of the deaths of hundreds of settlers at Jamestown, a royal commission is formed to investigate the Virginia Company of London. John Smith testifies during the investigation, and it is during this time that he revises his Generall Historie.
1624 - John Smith's The Generall Historie of Virginia, New-England, and the Summer Isles, which emphasizes treacherous natives, a heroic Smith, and the one "good" Indian, "Princess Pocahontas," is published. Historians have since questioned its reliability.
1626 - John Smith's An Accidence, or The Pathway to Experience is published.
1629 - John Smith interviews several Virginia settlers then visiting England and inquires about conditions in the colony.
1630 - The True Travels, Adventures, and Observations of Captaine John Smith is published.
1631 - Advertisements for the unexperienced Planters of New England, or anywhere, by John Smith, is published.
June 21, 1631 - A seriously ill John Smith makes his will and dies the same day. He is buried in Saint Sepulchre, an Anglican church in London.
Further Reading
Cite This Entry
- APA Citation:
McCartney, M. John Smith (bap. 1580–1631). (2016, April 7). In Encyclopedia Virginia. Retrieved from http://www.EncyclopediaVirginia.org/Smith_John_bap_1580-1631.
- MLA Citation:
McCartney, Martha. "John Smith (bap. 1580–1631)." Encyclopedia Virginia. Virginia Foundation for the Humanities, 7 Apr. 2016. Web. READ_DATE.
First published: January 4, 2012 | Last modified: April 7, 2016
Contributed by Martha McCartney, a historian and independent researcher in Williamsburg.


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Performer: Southwest Research Institute
End Users: National Institute of Justice and state and local law enforcement
Transition: Validate armor performance at National Institute of Standards and Technology Material solution will be integrated with commercial armor systems for enhanced protection

subset: commoncrawl


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Drugs & Medications - APOKYN subcutaneous
APOKYN subcutaneous
Common Brand Name(s): Apokyn
APOKYN subcutaneous Warnings
APOKYN subcutaneous Uses
This medication is used to treat the symptoms of Parkinson's disease. It can improve your ability to move during frequent "off" periods. It can decrease shakiness (tremor), stiffness, slowed movement, and unsteadiness. This medication is thought to work by helping to restore the balance of a certain natural substance (dopamine) in the brain.
Apomorphine is used to treat "off" episodes when they occur. It is not used to prevent "off" episodes. This drug should not be used instead of your usual medications for Parkinson's disease. Continue taking all your medications as directed by your doctor.How to use APOKYN subcutaneous
Read the Patient Information Leaflet provided by your pharmacist before you start using apomorphine and each time you get a refill. If you have any questions, consult your doctor or pharmacist.
Learn all preparation and usage instructions in the product package. If any of the information is unclear, consult your doctor or pharmacist.
Before using, check this product visually for particles or discoloration. If either is present, do not use the liquid. Check the dose carefully before injecting. Apomorphine is given by the milliliter, not by the milligram. There are 10 milligrams of drug in each milliliter of this liquid, so if the wrong measuring unit is used, you may accidentally inject 10 times the amount of drug you need. Be sure you have the correct dose to prevent accidental overdose. If you are not sure how to measure your dose correctly, consult your pharmacist before injecting.
If you are using the prefilled cartridge/pen, keep track of the doses used to make sure there is enough medication left in the device to give you a full dose.
Clean the injection site before injecting. Inject this medication under the skin as needed to treat decreased/frozen muscle movement ("off" episode) as directed by your doctor. You may need to use this medication several times a day. Do not use a second injection for the same "off" episode. Wait at least 2 hours between injections.
Do not inject this medication into a vein. It is important to change the location of the injection site with each dose to avoid problem areas under the skin. Therefore, choose a different injection site with each dose. The abdomen, thighs, and upper arms are recommended sites for the injection. Do not inject into skin that is irritated, sore, or infected. Learn how to store and discard needles and medical supplies safely. Never reuse syringes or needles. Consult your pharmacist for details.
Dosage is based on your medical condition and response to treatment. To decrease the risk of side effects (e.g., nausea, drowsiness, low blood pressure) when you first start using apomorphine, your doctor will slowly increase your dosage until the best dose for you is reached. Your doctor will usually have you use the first dose in the office where your blood pressure can be checked and you can be watched for side effects. A health care professional will also teach you to inject this medication correctly. Nausea is very common with this medication. To decrease the risk of nausea, your doctor may direct you to start taking another medication (e.g., trimethobenzamide) 3 days before your first dose of apomorphine and to continue taking it for at least 2 months.
Use this medication as prescribed. If you stop using this medication for longer than 1 week, you may need to increase your dose slowly back to your previous dosage. Talk with your doctor about how to restart the medication. Do not stop using this medication without your doctor's approval. If you have been using this medication frequently and suddenly stop using this drug, withdrawal reactions may occur. Such reactions can include fever, muscle stiffness, and confusion. Report any such reactions to your doctor right away.
Rarely, abnormal drug-seeking behavior (drug abuse) is possible with this medication. Do not increase your dose or use it more frequently than prescribed. Properly stop the medication when so directed.
Tell your doctor if your condition persists or worsens.
APOKYN subcutaneous Side Effects
Redness/swelling/pain/itching at the injection site, nausea, vomiting, headache, sweating, dizziness, drowsiness, yawning, or runny nose may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.
Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
Tell your doctor right away if any of these unlikely but serious side effects occur: uncontrolled movements, mental/mood changes (e.g., depression, hallucinations, trouble sleeping), muscle cramps/spasm, swelling of the hands/legs/ankles/feet, unusual strong urges (such as increased gambling, increased sexual urges).
Seek immediate medical attention if any of these rare but very serious side effects occur: chest pain, shortness of breath, unusually fast/pounding/irregular heartbeat, severe dizziness, fainting, slurred speech, vision changes, weakness on one side of the body.
Some people using apomorphine have fallen asleep suddenly during their usual daily activities (such as talking on the phone, driving). In some cases, sleep occurred without any feelings of drowsiness beforehand. This sleep effect may occur anytime during treatment with apomorphine even if you have used this medication for a long time. If you experience increased sleepiness or fall asleep during the day, do not drive or take part in other possibly dangerous activities until you have discussed this effect with your doctor. Your risk of this sleep effect is increased by using alcohol or other medications that can make you drowsy. See also Precautions section.
You may also develop a sudden drop in blood pressure that can cause dizziness, nausea, and fainting. This effect may also increase your risk of a fall. This drop in blood pressure is more likely when you are first starting the medication, when your dose is increased, or when you get up suddenly. To lower your risk, get up slowly from a sitting or lying position. Avoid alcohol.
For males, in the very unlikely event you have a painful, prolonged erection (lasting more than 4 hours), stop using this drug and seek immediate medical attention, or permanent problems could occur.
A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
In the US -
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.
In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
APOKYN subcutaneous Precautions
Before using apomorphine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients (such as sulfites), which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history, especially of: asthma, heart problems (e.g., chest pain, heart attack), slow/fast/irregular heartbeat (e.g., arrhythmia), mental/mood disorders (e.g., confusion, hallucinations, psychosis, schizophrenia), kidney problems, liver problems, symptoms of low blood pressure (e.g., dizziness, fainting), sleep disorder (e.g., sleep apnea, narcolepsy), stroke or other brain problem.
Apomorphine may cause a condition that affects the heart rhythm (QT prolongation). QT prolongation can rarely cause serious (rarely fatal) fast/irregular heartbeat and other symptoms (such as severe dizziness, fainting) that need medical attention right away.
The risk of QT prolongation may be increased if you have certain medical conditions or are taking other drugs that may cause QT prolongation. Before using apomorphine, tell your doctor or pharmacist of all the drugs you take and if you have any of the following conditions: certain heart problems (heart failure, slow heartbeat, QT prolongation in the EKG), family history of certain heart problems (QT prolongation in the EKG, sudden cardiac death).
Low levels of potassium or magnesium in the blood may also increase your risk of QT prolongation. This risk may increase if you use certain drugs (such as diuretics/"water pills") or if you have conditions such as severe sweating, diarrhea, or vomiting. Talk to your doctor about using apomorphine safely.
This drug may make you dizzy or drowsy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Avoid alcoholic beverages. See also Side Effects section.
Older adults may be at greater risk for the side effects of this drug, especially falls, hallucinations, and QT prolongation (see above).
During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.
It is unknown if this drug passes into breast milk. Consult your doctor before breast-feeding.
APOKYN subcutaneous Interactions
Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.
Some products that may interact with this drug include: alosetron, antipsychotics (e.g., chlorpromazine, haloperidol, thiothixene), certain drugs for nausea (e.g., metoclopramide, phenothiazines such as prochlorperazine, serotonin blockers such as ondansetron, granisetron), drugs for high blood pressure (e.g., beta blockers such as atenolol), vasodilators (e.g., nitrates), "water pills" (diuretics such as furosemide, thiazides).
Many drugs besides apomorphine may affect the heart rhythm (QT prolongation), including amiodarone, dofetilide, pimozide, procainamide, quinidine, sotalol, macrolide antibiotics (such as erythromycin), among others.
Tell your doctor or pharmacist if you are taking other products that cause drowsiness including alcohol, antihistamines (such as cetirizine, diphenhydramine), drugs for sleep or anxiety (such as alprazolam, diazepam, zolpidem), muscle relaxants (such as carisoprodol, cyclobenzaprine), and narcotic pain relievers (such as codeine, hydrocodone).
Check the labels on all your medicines (such as allergy or cough-and-cold products) because they may contain ingredients that cause drowsiness. Ask your pharmacist about using those products safely.
APOKYN subcutaneous Overdose
If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: very severe nausea/vomiting, loss of consciousness.NOTES:
Do not share this medication with others.
People with Parkinson's disease may have an increased risk for developing skin cancer (melanoma). Tell your doctor promptly if you notice a change in the appearance or size of moles or other unusual skin changes. Ask your doctor if you should have regular skin exams.MISSED DOSE:
Not applicable.STORAGE:
Store at room temperature at 77 degrees F (25 degrees C) away from light and moisture. Brief storage between 59-86 degrees F (15-30 degrees C) is permitted. Do not store in the bathroom. Keep all medicines away from children and pets.
Syringes can be filled the night before use and stored in the refrigerator until the next day. Discard this type of pre-filled syringe if not used in 24 hours.
Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.
Information last revised July 2016. Copyright(c) 2016 First Databank, Inc.
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.FDA.gov/medwatch or call 1-800-FDA-1088.
IMPORTANT: About User Reviews on RxList
RxList is part of the WebMD Health Network. The opinions expressed in the WebMD User Reviews are solely those of the User, who may or may not have medical or scientific training, and do not represent the opinions of WebMD. These member reviews have not been reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other purpose except for compliance with our Terms and Conditions. Some of these opinions may contain information about uses of the drug products that have not been approved by the U.S. Food and Drug Administration. WebMD does not endorse any specific product, service or treatment.
WebMD User Reviews should not be considered as medical advice and are not a substitute for professional medical advice, diagnosis, or treatment. Never delay or disregard seeking professional medical advice from your physician or other qualified healthcare provider because of something you have read on WebMD. You should always speak with your doctor before you start, stop, or change any prescribed part of your care plan or treatment. WebMD understands that reading individual, real-life experiences may be a helpful health information resource but they are never a substitute for professional medical advice from a qualified healthcare provider.


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Transform your photos into one-of-a-kind, hand painted masterpieces!
This product is currently out of stock.
Image Size
The image is near the edges of the product but doesn't cover the entire product. Some of the background color may appear around the outside edges of the image.
Background Color
Here it is... the towel that's taking the internet by storm. Our round beach towels are 60" in diameter and made from ultra-soft plush microfiber with a 100% cotton back. Perfect for a day at the beach, a picnic, an outdoor music festival, or just general home decor. This versatile summer essential is a must-have this season!
60" Diameter Not Including Tassles
Care Instructions
Machine wash cold and tumble dry with low heat.
Ships Within
2 - 3 business days
Liesl, thank you for your comment.
Amazing sky and beautiful painting! l/f
Beautiful work, Carole! Congratulations on your wonderful sale! F/L
Brian, thank you for your comment.
Congratulations, I like this a lot.
Andrea, thank you for your comment.
Congratulations on your sale!
Claudia, thank you for your comment.
Judith, thank you for your comment.
Congratulations, Carole, on your sale!
simply awesome, congrats!
Nina, thank you for your comment.
Congratulations! 😎
Teresa, thank you for your comment.
Very nice work...
Sorin, thank you for your comment.
Congratulation on your sale, lovely painting!
Evelina, thank you for your comment.
Fabulous. Congratulations!
Georgia, thank you for your comment.
Congratulations on your sale!!!!
Bill, thank you for your comment.
Thank you Andrew..pond hockey is invigorating..no floor boards..just open vistas..not that I play.,.but I have watched some local games like these..really something to see!!
Average Rating (5 Stars):
Charles Rogers
August 29th, 2018
Judy Bostrom
July 28th, 2018
Karoll Domeij
July 27th, 2018
Kay Roberson
July 19th, 2018
Wow - I didn't realise it was going to be that big! It's a gift for a young member of the family - I think he'll be thrilled as he's a tractor fanatic at 6 years old. A practical gift too. The towel has a smoother upper side so it'll be more comfortable to sit on at the beach. It seems to have a thick absorbent power so no usual skinny beach towel.
CAROLE SPANDAU is a CANADIAN FINE ARTIST,specializing in MONTREAL STREET SCENE PAINTINGS, QUEBEC LANDSCAPES, URBAN CITY SCENES, HOCKEY ART, AND CONTEMPORARY PORTRAITS. GRADUATE of ECOLE DES BEAUX ARTS BACHELOR OF FINE ARTS DEGREE; MCGILL UNIVERSITY BACHELOR OF ART EDUCATION; CONCORDIA GRADUATE STUDIES ART HISTORY. Represented in Montreal by GALERIE ATELIER TOILE ETOILE, contact G.Venditti Artist rep at 514-486-0731 Carole Spandau was recently honored by CTV NEWS NET featuring her delightful paintings of Montreal street scenes. The interview aired repeatedly, coast to coast across Canada, resulting in a flood of new-client requests for her beautiful paintings of Montreal's magnificent winding staircases, nostalgic scenes of...
Our return policy is very simple:
If you're not happy with a purchase that you made on Pixels.com, for any reason, you can return it to us within 30 days of the order date. As soon as it arrives, we'll issue a full refund for the entire purchase price. Please note - Pixels does not reimburse the outgoing or return shipping charges unless the return is due to a defect in quality.
Pixels sells thousands of pieces of artwork each month - all with a 100% money-back guarantee. We take great pride in the fact that hundreds of thousands of artists have chosen Pixels to fulfill their orders, and we look forward to helping you select your next piece!
All round beach towels ship from our production facility within 2 - 3 business days of your order.


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NORRISTOWN - Data presented by the Montgomery County Planning Commission shows the median price of homes in the county increased in 2013.
The report shows the median price of a home in Montgomery County was $267,000, a 4.7 percent increase from the county's median price of a house in 2012. The report also shows that in 2013 the county had 9,885 market-rate home sales.
"Both of these figures are very positive indicators that the housing market is actually finally recovering after the housing bubble and its subsequent bursting and the great recession that's really plagued us over the past five, six years," Senior Planner Scott France said Wednesday at the meeting of the planning commission board.
"This is a definitive indicator that our economy in Montgomery County is getting stronger every day, and that Montgomery County remains one of the main engines that drives the Pennsylvania economy," Josh Shapiro, chairman of the Montgomery County commissioners, said in a press release handed out at the board meeting.
The report took into account single-family detached homes, single-family attached townhouses and multifamily units, which consist largely of apartments and condominiums. Overall, the prices for single-family detached and single-family attached homes went up, while the median price for multifamily units went down by about $1,000, France said.
"The big culprit there, with multifamily, is that you're not seeing new owner-occupied multifamily units built," he said. "Everything new being built in that category is going to the rental market."
France said although there is a positive trend beginning in 2012, the bad news comes when adjusting for inflation.
"We took each year and put it in 2013 dollars. The overall gain for the 10-year period was about 22 percent by inflation. The 2013 value of these 2004, '05, '06 and '07 homes is well above where we are today," France said.
By 2013 dollars, the median value of homes sold in 2004, 2005, 2006 was over $300,000, according to a chart in the report.
The report shows that 45 of 62 townships and municipalities in the county have "experienced an increase in their overall median sales price." In the past seven years, more than half of the municipalities in the county saw a decrease in their median home price, France said.
However, France explained to the board members that inventory is "being stifled" and there are not as many houses on the market now as there were this time in 2013.
"We'll have to see how that plays throughout 2014," France said.
Seventeen of the county's municipalities saw a decrease in the median price of homes. West Conshohocken's median home value dropped $79,870 in 2013. In 2012, France said, West Conshohocken had the fourth highest increase in median value.
France said the decline in West Conshohocken was due to the small number of units sold.
The most expensive homes in 2013 were in Lower Merion, Lower Gwynedd, Bryn Athyn and Upper Salford. The most affordable homes in the county were found in Norristown, Pottstown and West Pottsgrove.
The planning commission issues a report on median home prices in the county every year. The data for the report come from the Montgomery County Board of Assessment Appeals records. Homes sold for less than $20,000 in 2013 were excluded from the report. The data is based on homes sold during 2013, not the value of all housing units in the county.


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Search results for: Us Raw Gold Buyers
Us Raw Gold Buyers
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Art Deco Jewelry Retailer (Rating: 1) , Votes:Estate diamond buyers offer antique lovers thousands of pieces of diamond estate jewelry. Site features many pieces of period jewelry, Art Deco jewelry, and examples of various stylistic trends.http://www.langantiques.com
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Claddagh Jewelry (Rating: 5) , Votes:Factory Direct Jewelry is a jewelry manufacturing company, located in the heart of the Jewelry District in Downtown, Los Angeles, specializing in claddagh and Celtic jewelry.http://www.factorydirectjewelry.com
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Car Loan Calculator (Rating: 0) , Votes:Provides free calculation tools for car buyers. Offers estimated monthly payment amounts and helps shoppers figure out which vehicles are within budget.http://www.carloancalculator.org/Category: Directory/Shopping/Automotive
Diamond Engagement Rings (Rating: 18) , Votes:Novori offers a wide array of engagement rings, wedding rings as well as diamond studs, earrings, bracelets and pendants.http://www.novori.com
MortgageCalculator.biz (Rating: 0) , Votes:Free online real estate calculation tools for home buyers and sellers.http://www.mortgagecalculator.biz/
Quincy MA Real Estate & Milton MA Real Estate (Rating: 2) , Votes:Buy or sell a home on Boston's south shore. Featured communities include Quincy MA, Weymouth MA, Braintree, MA and Milton, MA.http://www.MyBostonSouthShoreHome.com
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San Fernando Valley Real Estate (Rating: 35) , Votes:David Hitt, a San Fernando Valley realtor, has been serving buyers and sellers in the San Fernando Valley areas for over 10 years. His knowledge of the real estate market in Encino, Sherman Oaks, Lake Balboa, Studio City, Van Nuys and North Hollywood have helped him achieve an excellent reputation throughout the Coldwell Banker network.http://www.san-fernando-valley-ca-real-estate.comCategory: Directory/North America/California
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Prepaid Phone Cards by Email & Online Calling Card (Rating: 30) , Votes:Phone Card Depot retails prepaid phone cards delivered via e-mail, international phone cards and online calling cards. Our top selling cards include: CiCi, Gold, Global Papa, AVEO, The Good Card, SIFA, First Choice and Yak.http://www.phonecarddepot.comCategory: Directory/Business/Telecommunications
UK Relocation Agents (Rating: 0) , Votes:Black Brick is a leading, independent buying agency, providing expert advice to buyers in London, the Home Counties and the South East.http://www.black-brick.com/Category: Directory/Europe/United Kingdom/London
Relining Services (Rating: 0) , Votes:Pipe relining services rehabilitate all drains and grease traps on the Gold Coast - contact our specialists today for full information and free quotes.http://www.reliningservices.com.au/
First Mortgage - UK Mortgage Qutoes and Information (Rating: 7) , Votes:A free, independent, impartial UK mortgage search resource - first time buyers, remortgages, adverse credit history - all provided for.http://www.firstmortgage.co.uk
We Buy Any House, Anywhere In The UK | House Buy Fast (Rating: 4) , Votes:We will buy your house if it's located in the United Kingdom. Sell your house fast today.https://housebuyfast.co.uk/we-buy-any-house/
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Webotopia provides a business directory designed to promote Us Raw Gold Buyers companies, products and services whilst helping it's users find the Us Raw Gold Buyers information they need. Webotopia business directory, with the help of it's dedicated support specialists and reviewers, enables delivery of Us Raw Gold Buyers quality content, excellent customer support as well as value added services such as content publishing and press releases for it's users.


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'Lookbook Cookbook' Combines Gorgeous Women With Healthy Food
It's remarkable how the presence of pictures of hot women can turn the most mundane activities into the scientific phenomenon known as "BOING!" We stumbled upon Lookbook Cookbook, which somehow turned us into devotees of the vegan arts by tricking us with pictures of beautiful girls.
The site ingeniously posts links to recipes accompanying giant pictures of gorgeous models enjoying the fruits of their labors. The insinuation is that if we indulged in these types of non-'Hungry Man' eats, and perhaps even learn how to make them, that women who look like these ladies will chomp into our revolting soy dishes with lustful longing.
This is all pure fantasy, of course, because as our life experiences have proven, nothing drives a girl crazy like a McDonald's No. 1 value meal. By "girl" we mean "the elderly crack addict on the corner who gives us a toothless smile when we give her our leftovers." Dorothy needs loving too. A shower and clean underwear wouldn't hurt either.
[Via Lookbook Cookbook]


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Cocker Spaniel (Brown) Dog OrnamentBe the first one to write a review
Price:$42.00in stockNewView more Dog Ornaments
Cocker Spaniel (Brown) Dog Ornament. Our Cocker Spaniel Dog Ornament is part of the Pet Set Collection endorsed by Betty White to benefit The Morris Animal Foundation.
The Cocker Spaniel Glass Dog Ornament is hand made by artists who first create a mold for the dog breed, then the glass is blown and hand painted. Our ornaments are made in Europe. The ornament measures approximately 4 inches - a simply gorgeous collectible for the Cocker Spaniel Dog Lover!
Order early as these are quite popular ornaments!
Hawaii, Alaska and International Customers - please contact us for ordering and shipping cost information PRIOR to placing order.
Material:Blown Glass
Delivery Time:Ships within 5 Business Days of Order


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Kyiv, Ukraine — U.S. Agency for International Development (USAID) Administrator Rajiv Shah on June 18 announced $10 million in additional U.S. support for Ukraine, largely for corruption-fighting measures. The support furthers the U.S. government's commitment to fighting corruption, especially with stakeholders and in areas not previously addressed, by helping Ukrainians develop institutions and mechanisms to better monitor how their government is working for them.
"Across the world, we see how corruption stifles dreams and limits opportunity," said Shah. "By working hand in hand with our partners to increase transparency, we can unlock broad-based economic growth and strengthen democratic governance in Ukraine for generations to come."
Shah announced the investment during remarks at the Kyiv National Economics University before an audience of students, staff, civil society and government ministers.
The government of Ukraine has acknowledged the need to address corruption by enacting systemic changes that will deter, detect, investigate and prosecute corruption. Civil society has been most active in leading this fight through a Reanimation Reform Package, a comprehensive collection of draft legislation to serve as a road map for government reforms.
USAID's programming across all sectors in Ukraine — including democracy and governance, economic development and health — continuously works to prevent corruption and increase transparency. Support includes efforts to address accountability of government officials, fair and transparent judicial systems, transparent public procurement and transparent energy sector regulation.
In Ukraine, Shah visited Kyiv and Odesa, where he met with top government officials, including Prime Minister Arseniy Yatsenyuk. Throughout the trip, Shah will discuss U.S. efforts to attract business investment and support anti-corruption efforts.
Over the past 20 years, USAID has invested close to $2 billion in Ukraine to build a stronger, more stable economy, develop and strengthen democratic structures, strengthen civil society and provide better health care.
More recently, USAID helped provide a sovereign loan guarantee on $1 billion, which saved Ukraine at least $280 million in interest payments and helped to stabilize the economy, and provided critical support to the successful Ukrainian presidential election on May 25.


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7 Adorable 'Santa Babies' [PHOTOS]
Every family has its strange holiday traditions and some of those include dressing up tiny, innocent infants as the world's most famous elderly gift giver. Here's a list of the 7 different kinds of Santa Babies you might end up meeting online or in real life this holiday season. And lest you think that we're making fun of the babies in these photos, relax and have some gingerbread. We're just celebrating the many types of kids who help bring cheer to the holiday season. Happy holidays!


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Consumers might have done a bit more shopping in February than in January, but nobody thinks retail spending heated up last month.
Economists polled by MarketWatch figure that retail sales rose about 0.2% in February after a 0.4% decline in the first month of the year. Harsh weather – it was one of the coldest months in years – likely constrained sales but not as much as in January. Auto sales rose a bit and economists expect a snapback in online purchases.
Retail sales account for about one-third of consumer spending and they are a good barometer of whether the economy is getting stronger. Yet the trend in sales has been little changed over the past few years.
Also on Thursday, weekly jobless claims are expected to rise slightly to 330,000 in the first week of March from 323,000 in the last week of February. Initial claims are a proxy for company layoffs and they have hovered around 330,000 for months.
That's consistent historically with monthly employment growth in the 175,000-plus range, economists say.
Wall Street will also key in on the question-and-answer segment during a Senate hearing with three nominees to join the Federal Reserve. The three nominees released their written testimony on Wednesday a day ahead of the hearings.
The most prominent nominee, Stanley Fischer, said that economic "normalcy" still has not been restored more than four and a half years after the recession ended.
- Jeffry Bartash
Follow Jeffry on Twitter @jbartash
Follow Capitol Report on Twitter @capitolreport
Also read: Obscure survey points to fourth-quarter GDP recapturing 3% level


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Description: Hat of striped felt. The hat is formed as a "pancake beret" on a rigid, slightly curved frame. The crown is of felt with wide width-wise stripes of olive green and black. The edge is embellished with a swagged band of bronze and black beads which runs from just behind the midway point of the side of the hat, around the front, and to just behind the midway point on the other side of the hat. The interior of the hat is lined in black fabric, and there is an inner hatband of black grosgrain ribbon. Maker's label sewn to inner hatband: "Chez Henriette".
Date: 1955
Creator: Chez Henriette
Item Type: Refine your search to only Physical Object
Partner: UNT College of Visual Arts + Design


text: « Return to Search Scientists Find that Chromosomal Abnormalities Are Associated with Aging and Cancer May 08, 2012 Scientists Find that Chromosomal Abnormalities Are Associated with Aging and Cancer Contacts: NCI Office of Media Relations 301-496-6641 NHGI Press Office 301-401-0911 Mass. Eye and Ear: Mary Leach 617-573-4170 Mass. Eye and Ear Researchers Among Authors of Study online in Nature Genetics (May 8, 2012) - Two new studies have found that large structural abnormalities in chromosomes, some of which have been associated with increased risk of cancer, can be detected in a small fraction of people without a prior history of cancer. The studies found that these alterations in chromosomes appear to increase with age, particularly after the age of 50, and may be associated with an increased risk for cancer. These studies were conducted by two consortia, one led by scientists at the National Cancer Institute (NCI), and one by Gene Environment Association Studies (GENEVA) which is sponsored by the National Human Genome Research Institute (NHGRI). NCI and NHGRI are both parts of the National Institutes of Health. The results of the studies were published online May 6, 2012, in Nature Genetics. "Accounting for these chromosomal abnormalities is routine in the search for new gene variants associated with complex diseases like primary open-angle glaucoma. This work illustrates that the highly collaborative efforts of researchers across disciplines can translate into important scientific observations that transcend the specific interests of individual research groups", said Dr. Louis R. Pasquale, a senior author on the GENEVA consortium publication and Director of the Glaucoma Service at Mass. Eye and Ear. Drs. Janey Wiggs and Pasquale from Mass. Eye and Ear and Dr. Jae Hee Kang from Channing Lab at Brigham and Women's Hospital contributed data to the GENEVA consortium study. Mosaicism, the type of structural abnormality in chromosomes that is described in these studies, results from a DNA alteration that is present in some of the body's cells but not in others. A person with mosaicism has a mixture of normal and mutated cells. "These two studies provide large population-based evidence that genetic mosaicism increases with age and could be a risk factor for cancer. This last point raises an important issue with respect to the stability of a person's genome and suggests that detection of genetic mosaicism could be an early marker for detecting cancer, or perhaps other chronic diseases," said Stephen Chanock, M.D., co-author and chief, Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, NCI. Scientists began observing an unexpected frequency of structural abnormalities in chromosomes during quality control checks of data from genome-wide association studies (GWAS) conducted in the GENEVA consortium and similar programs at NCI. These studies involve comparing hundreds of thousands of common differences across individual patients' DNA to see if any of those variants are associated with a known trait, such as cancer. At first, these abnormalities were thought to be errors or outcomes of laboratory procedures. But they were found consistently at a low frequency, so the scientists wondered with what frequency these structural abnormalities occurred in the general population. Previously, NCI investigators had reported that genetic mosaicism was observed in a population-based study in Spain. Since there were no accurate estimates of the frequency of mosaicism in the general population, NCI investigators looked at large mosaic chromosomal abnormalities in 31,717 cancer cases and 26,136 cancer-free controls from 13 GWAS. Similar analyses were conducted by investigators at the University of Washington, Seattle, collaborating with NHGRI and NCI investigators in the GENEVA consortium. The 16 GENEVA studies included participants of all ages and have been focused on several different chronic diseases, but only a small proportion of these studies focused on cancer as the primary outcome. The NCI-led study observed that genetic mosaic abnormalities were more frequent in individuals with solid tumors (0.97 percent vs. 0.74 percent in cancer-free individuals). The NCI study also observed mosaic chromosomal abnormalities in slightly less than 1 percent of the study participants, but noted that the frequency of detectable genetic mosaicism increased with age. This was consistent with GENEVA results that found genetic mosaicism increased in those over the age of 50. The GENEVA investigators studied blood samples of over 50,000 participants and identified genetic mosaicism abnormalities in 404 of the participants, most of who were over age 50. They found genetic mosaicism abnormalities in 0.2 percent of people younger than age 30. From age 30 to age 50, mosaicism frequency rose; it increased sharply over age 60, with up to a 2.5 percent frequency above age 75. Past analyses suggest that mosaic abnormalities are often detectable in later life because they arise and accumulate over time and/or because the descendants of mosaic cells expand in numbers throughout the body and are more readily detected at older ages, the scientists say. "Repeated collection of blood samples may play a major role in helping determine how genetic mosaicism rises quickly at older ages. This is supported by observation of our only GENEVA subject who was sampled twice -- once at age 66 and again at age 72. While no mosaic abnormalities where detected in the earlier sample, the later sample contained five mosaic abnormalities, each on a different chromosome," said Teri Manolio, M.D., Ph.D., director, Office of Population Genomics, NHGRI . In both studies, scientists observed an increase in the detection of genetic mosaicism in patients with hematological cancers (leukemia, lymphoma, and myeloma), for which DNA was collected at least one year prior to diagnosis, compared to cancer-free individuals. Results from the NCI study showed that risk of leukemia was also substantially higher among people with these chromosomal alterations while the GENEVA study showed that the risk of acquiring a hematological cancer diagnosis was 10 times higher for people who had mosaic chromosomal abnormalities. The results of both studies suggest that mosaicism, observed in older people, may be an asymptomatic condition -- not often causing overt illness -- that may predispose them to hematological cancer. However, GENEVA and NCI scientists stress that the event numbers analyzed are small, and additional studies are needed across a broader diversity of populations to establish the clinical significance of these findings. NIH scientists say these findings will have important implications for the design and analysis of molecular studies of cancer, as well as ongoing studies looking at the characterization of cancer genomes, such as NIH's The Cancer Genome Atlas and the International Cancer Genome Consortium. NIH scientists recommended that additional analyses be conducted in groups of currently healthy people so that investigators may follow them over time for health outcomes. They also said that researchers may want to collect multiple DNA samples over many years to explore disease and treatment effects. Additional studies with subjects, sampled at multiple ages, will be invaluable in the evaluation of the origin and stability of mosaic abnormalities. ### References: 1) Jacobs KB, et al. Detectable clonal mosaicism and its relationship to aging and cancer. Nature Genetics. May 6, 2012. DOI: 10.1038/ng.2270. 2) Laurie CC, et al. Detectable clonal mosaicism from birth to old age and its relationship to cancer. Nature Genetics. May 6, 2012. DOI: 10.1038/ng.2271. The National Cancer Institute (NCI) leads the National Cancer Program and the NIH effort to dramatically reduce the burden of cancer and improve the lives of cancer patients and their families, through research into prevention and cancer biology, the development of new interventions, and the training and mentoring of new researchers. For more information about cancer, please visit the NCI Web site at http://www.cancer.gov or call NCI's Cancer Information Service at 1-800-4-CANCER (1-800-422-6237). NHGRI supports the development of resources and technology that will accelerate genome research and its application to human health. Additional information about NHGRI can be found at its website, http://www.genome.gov. NIH, the nation's medical research agency, includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit www.nih.gov.


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Welcome to Midstate Amusement Games
Is your bar, restaurant, or business in need of amusement games to entertain your patrons? If so you've come to the right place! We are a family owned coin machine operator that provides a wide spectrum of gaming products and services to businesses in East Central Wisconsin including Oshkosh, Fond du Lac, West Bend, Ripon, Mayville, and Waupun. Our product line includes many of today's most popular entertainment products such as arcade games (Big Buck Hunter, Golden Tee, Silver Strike), pool tables, dart boards, bar top games, foosball tables, ATM's, and state of the art digital TouchTunes jukeboxes with smart phone apps.
In addition to our full line of entertainment gaming products we offer league management services for many games (Pool, Darts, Foosball, Golden Tee, Silver Strike, Big Buck Hunter) in our service area.
We're also your connection for rec room entertainment. Looking for that arcade game, dart board or pool table for you home? Look no further, we have a large stock of used equipment for sale at incredible prices including Valley dart machines starting at $700, Tornado Foosball tables starting at $600 and Valley Dynamo pool tables starting at just $900. If you love those old arcade games we have a variety of titles to choose from. To inquire about game availability, call at 920.921.5000 and ask for Joey or Bruce or shop our used games online.
Featured Amusement Products
Arachnid Hot Buttons
Big Buck Hunter
Golden Tee Golf


text: My 330 A/BP (serial # HJ191607) is acting up on me. No matter what setting I put it on; it runs at max amps no matter what position the Rheostat is in. I tested the rheostat and it does not fluctuate ohms of resistance when I move it. I'm 99.9% sure that is my problem, but wanted to see if there was anything else I should check before I spend the money. BTW, I found the Rheostat at a really good price ($53 to my door) here and it is the same miller part number: https://weldingsupply.com/cgi-bin/remember.pl


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Online Enrollment
Go Direct® Online Enrollment
The Go Direct Online Enrollment system is a secure website that provides financial institutions a quick and easy method for enrolling federal benefit check recipients to direct deposit. The Online Enrollment system will continue to be available to financial institutions and check recipients for the foreseeable future.
Learn more about Online Enrollment for financial institutions in this Quick Guide for Financial Institutions. For a more complete step-by-step guide, view the Direct Deposit Online Enrollment User Guide for Financial Institutions.


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SANTA BARBARA, Calif. – In a defensive battle on Sunday afternoon at Meredith Field at Harder Stadium, the New Mexico women's soccer team came out on top, defeating UC Santa Barbara, 1-0.
With the loss, UCSB falls to 2-3-1 on the season while New Mexico improves to 3-1-2.
The Lobos used a free kick in the 73rd minute to seal the win. Jennifer Williams launched the ball into the box from 35 yards out on the right side and Shelbie Luna was able to head it towards Roxie McFarland, who was just outside the left post. The senior shot the ball to upper left hand corner of the Gauchos' goal for the eventual gamewinner.
The contest was tightly contested throughout with New Mexico leading the shot count, 9-6.
UCSB had the first shot on-frame with 7:24 to go during the first half. Allie Ariniello passed the ball to Indiana Mead who shot it to the right side, but goalkeeper Kelli Cornell made an impressive diving save to hold off the Gauchos. It would turn out to be UCSB's only shot on-goal during the contest.
With just one minute remaining in the first half, it was time for Gaucho goalkeeper McKenna Henry to provide some heroics of her own. Elizabeth Nare got the ball about 18 yards out where to she sent a low liner towards the right hand post of the UCSB goal. Henry dove to her left where she was able to cover the loose ball and maintain the 0-0 stalemate.
It was not long into the second period that Henry made her second save of the game as she blocked a shot from Williams on the left side of the goal. She ended the game with three saves.
Following the Lobos' goal, UCSB controlled the tempo during the remainder of the game, but could only manage to get off a pair of shots that sailed high and wide.
"It was just a tale of two halves," head coach Paul Stumpf said. "We couldn't put anything together in the first half. We didn't put enough pressure on them, we weren't clean with the skills, and we weren't fast on the ball. And the (New Mexico) coaches got on them and told the team that they needed to track and pass. I mean, we couldn't make a mess out there.
"So we took them in at halftime and told them that and they came out and played a second half that was so much better. As disappointed as I was about the result, I really enjoyed the way we were playing in the second half. And I am encouraged that the team found that they could play hard on a Sunday after a Friday game."
GKids is the official kids club of UCSB Athletics available to kids in eighth grade or younger. Members receive the official 2011-12 GKids t-shirt, Olé's Coloring Book and Guide for Being a Gaucho, entry into every regular season soccer, basketball, baseball, softball and volleyball game, and much more! To sign up today, click here.


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Subscribe and get unlimited access.
Be inspired by the best creative work from around the world.
AlmapBBDO is the agency that naturally combines relevant strategic planning with seductive creative ideas.
The agency is proud of what it does and the values it seeks with conviction: simplicity, objectivity and willingness to learn more every day, with a team formed by wonderful people that know that a job well done is the most sustainable way of being successful.


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Your Memberships and Donations are very important to us!
By joining EEAO, you are helping support all of our events, professional development opportunities, and our ongoing work to professionalize environmental education. We are 100% all-volunteer board with a small part-time staff and contractors.
We welcome your input in developing our policies and priorities and offer you opportunities for networking and collaborations, EE advocacy alerts, grant opportunities, job listings, and a listing in our Resource Directory. Your membership will connect you with others within your region and across the state who are passionate about environmental education and outdoor learning. Be in the know about what is happening across our state around EE.
We invite you to Become A Member or Donate either on line or by mail. Thank you!
We encourage you to donate to our conference scholarship fund to help cover fees for students and professionals attending the 2018 conference at a reduce rate.


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Item Number: KF07005BK
66-79 F150 Bronco 4 Deg 14Pc Kit
Track arms, strut arms, and radius arms are critical links between the axles and the rest of your vehicle. Excessive slack or movement caused by worn bushings at these important suspension points can cause all kinds of poor ride and handling characteristics. Even minor wear can have a substantial impact on a vehicle's handling behavior.
Daystar takes special note of all the bushings used in these applications and utilizes the expertise that only 30 years in the business can supply to build bushings that will last in these demanding environments. Precision-engineered to be a direct replacement for factory bushings, Daystar's bushing kits will provide years of trouble-free operation. In the case of solid-axle radius arm applications, a variety of different bushings are available to restore caster lost during a suspension lift. Quality, versatility, and reliability sum up Daystar's commitment to build the finest bushings that money can buy.


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Account Activation
Attention PDF subscribers, please remember to email your user name to email@example.com! We cannot activate your subscription until you contact us with that information. Thank you!
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For those subscribed to the Pennsic Independent PDF edition, this page is your source for links to the download files:
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Click for weather forecast


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News & Events
For the Media
Clarkson University to Commemorate Martin Luther King Jr. Day
Clarkson University will commemorate Martin Luther King Jr. Day on Monday, January 21, with a series of events focused on creating a more peaceful world. All events are open to the public and free.
Professor Arthur Romano, a faculty member at George Mason University's School of Conflict Resolution and Analysis, will keynote two discussions. At 3 p.m. in the Cheel Campus Center Cheel Commons, he will present "Civility and Difference: Sustaining Conversations that Matter on Campus," which will focus on creating candid but respectful dialogue that addresses issues of difference. At 6 p.m. in the Student Center Multi-purpose Rooms, Romano will present "Call to Conscience," which will bring Dr. King's teachings to life and illustrate how they continue to inspire people worldwide.
At 5 p.m. in the Student Center Forum, students who speak a second language will bring posters with words of peace in that language. Those will be transferred to "peace poles" to be dedicated on campus in the fall.
At 5:30 p.m. in the Student Center Multi-purpose Rooms, the Diversity Initiatives Office will present its annual Martin Luther King Jr. Award, which honors a campus community member for their extraordinary leadership. This year's recipient is Kurt Stimeling, Clarkson's former dean of students.
Romano is a certified nonviolence trainer and accomplished international educator who has worked globally to challenge violence and promote peace. He most recently worked with university students and staff from more than 50 nations implementing key community building projects that challenged violence on campus and supported peaceful ways of living.
Romano has spoken several times at the United Nations and has collaborated with its Department of Public Information to promote the Gandhi-King Season for Nonviolence and the International Day of Peace. In 2004, he was awarded the prestigious Rotary World Peace Fellowship for studying conflict resolution and has conducted research on university level peace studies programs in India, Japan, the United States and the United Kingdom.
In the days following the violence of September 11th, Romano joined with a group of concerned citizens to counteract the narrowing national debate and increasing calls for retaliatory measures in response to those attacks. The World Peace Walk resulted, with members walking more 300 miles from the former site of the World Trade Towers to the Pentagon. During that time, Romano met with people from all walks of life and helped to provide a space for communities to grieve and explore the possibilities for nonviolent responses to those acts of hatred. Arthur continues to work to further cross-cultural and interfaith understanding, including efforts to promote dialogue between Americans and people from abroad with focused interest on increasing direct face-to-face diplomacy and exchange.
Clarkson University launches leaders into the global economy. One in five alumni already leads as a CEO, VP or equivalent senior executive of a company. Located just outside the Adirondack Park in Potsdam, N.Y., Clarkson is a nationally recognized research university for undergraduates with select graduate programs in signature areas of academic excellence directed toward the world's pressing issues. Through 50 rigorous programs of study in engineering, business, arts, sciences and health sciences, the entire learning-living community spans boundaries across disciplines, nations and cultures to build powers of observation, challenge the status quo, and connect discovery and engineering innovation with enterprise.
[A photograph for media use is available at http://www.clarkson.edu/news/photos/aromano.jpg.]
Photo caption: Professor Arthur Romano, a faculty member at George Mason University's School of Conflict Resolution and Analysis, will keynote two discussions at Clarkson University's Martin Luther King Jr. Day commemoration on Monday, January 21.


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When a colleague encountered something unfamiliar while working on a collection of documents and asked me if I knew anything about "V-Mail," I thought she must be referring to some new and exotic form of electronic mail. I was unaware that the term "vmail" was currently used by some people as shorthand for voice mail. But rather than the present, her question led to the past and a form of mail devised in exceptional circumstances—World War II—and making use of technology, albeit of a non-electronic kind.
A little digging and a helpful web page turned up a wealth of details on the subject of V-Mail. It turned out that the V stood for Victory, a word ubiquitous in the discourse of the Allied war effort, which had already seen the promotion of Victory gardens (to grow vegetables on the home front) and the sale of Victory bonds (to raise money from the public). V-Mail referred to a process whereby correspondence being sent to troops overseas was microfilmed to reduce its physical volume so as to free up space on cargo planes for war material.
The basic V-Mail program was fairly simple. One used standardized stationery on which to write letters; the letters were then microfilmed, and the microfilm was then shipped overseas, where it was developed and then delivered. But behind this lay a formidable logistic undertaking. Processing centers had to established, both in the United States and abroad, requiring significant amounts of personnel and equipment. Eastman Kodak was awarded the contract for the microfilm machines, and V-Mail detachments were created in the postal units of the armed forces. Three regional centers were established in the United States (San Francisco, New York, and Chicago) to process V-Mail, along with numerous stations overseas.
The archives has a number of promotional posters that stress V-Mail's reliability and speed and suggest that it was the "most patriotic" way to send mail to troops. One poster details the savings that V-Mail created in terms of cargo space. Its morale-boosting importance was another theme, captured in the slogan "You write, he'll fight." Of course, like other mail sent during wartime, V-Mail was subject to censorship.
The V-Mail program lasted from June 1942 until November 1945, but the mail itself has survived and thus remains available. The same may not hold true for e-mail, at least in its electronic form. As technology and formats change, files may not always remain recoverable, a challenge with which archivists are beginning to grapple.
A fuller description of the specifics of the V-Mail program can be found at the National Postal Museum section of the Smithsonian Institution's web page.
Wednesday, July 28, 2010
You've Got V-Mail
Posted by David Jacobs at 1:13 PM
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EXCLUSIVE: After weeks of speculation that Martin Scorsese's "Wolf of Wall Street" wouldn't hit theaters until 2014, the financial drama will arrive on Christmas Day and thrust a late entrant into the Oscar race, say three people close to the film.
But in the process, the Paramount release will likely bump the Tom Clancy reboot "Jack Ryan: Shadow Recruit," which Paramount has scheduled to open the same day, to early 2014.
"Wolf of Wall Street," adapted from Jordan Belfort's memoir about his meteoric rise and fall as a trader in the 1980s and '90s, was originally set to open Nov. 15, but Scorsese and longtime editor Thelma Schoonmaker have not yet finished the movie, and making that date has long been considered impossible. A recent cut of the film came in at about three hours; Scorsese is in the process of trimming the film.
SNEAKS: Movie trailers, full coverage
The film stars Leonardo DiCaprio as Belfort, and the cast includes Jonah Hill and Matthew McConaughey.
As for "Ryan," the Clancy-inspired film is likely to come out in the first quarter, possibly in late January. The movie, which saw new marketing materials released just several weeks ago and gained fresh interest in the wake of Clancy's recent death, will apparently now do battle in a less crowded but potentially less lucrative period.
Paramount could, of course, keep "Ryan" in December, though studios tend to maintain at least several weeks of distance between their big releases.
Paramount is expected to announce its new plans in the coming days.
The studio previously postponed the release of Scorsese's "Shutter Island" from 2009 to 2010, but that film was not considered an Oscar contender. Scorsese was an award-season player two years ago with the fall release of his 3-D period picture "Hugo."
"Wolf of Wall Street" was independently financed by Red Granite ("Friends With Kids," the upcoming "Out of the Furnace"), with Paramount serving as the film's domestic distributor.
A spokeswoman for Red Granite did not immediately return a call and e-mail seeking comment. Paramount declined to comment on the release plans for either film.
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