text:
Updated 03/12/2016
Created by Anton
Updated 03/29/2017
Created by Adam
Good Luck
Updated 01/02/2019
Created by 이준용
famous islands in europe
Updated 11/17/2017
Created by Pietro008.pg
Updated 05/13/2016
Created by Aidan Flanigan
Updated 2 days ago
Created by Mikael Falgard
Outdoor stadiums only. Good luck!
Updated 03/23/2016
Created by unibwin
Rediscover the World with this updated map providing better diversity, more countries, without any blurry pictures or photosphere! 14.000+ hand-picked locations. Big rework in progress! FULL MAP DETAILS: https://goo.gl/Gj76EF | v3.0b13 • 2019/03/19
Updated yesterday
Created by Mapper
Updated 03/16/2016
Created by Elgan Rees Evans
This is like "A Diverse World" but only inside towns (from biggest towns to smaller towns in lesser developed countries). 600+ towns included for now. If you get a photosphere please report it to /u/KilleMapper on Reddit, thanks. | 1.6.1 • 2019/04/23
Updated 07/04/2018
Updated 06/05/2016
Created by Austrolepelican
Updated 03/28/2016
Created by Zanko Ralenekov
Created by Awhitmore
Updated 08/12/2016
Created by Edd82


text:
Sheet music downloads have become the preferred method of acquiring classical music repertoire. Created by professional musicians, EveryNote.com presents classical sheet music download of over 20.000 popular and hard-to-find music scores over 1000 composers. A major Internet provider of classical sheet music files download online, EveryNote.com offers the largest and most complete digital sheet music download library on the Web in the world. Instantly download, view and print your favorite classical music score. Everynote.com currently offers thousands of classical music compositions for Piano, Violin, Cello, Flute, Clarinet, Classical Guitar, Voice, Chamber and Choral music.Many more instruments, composers, genres added every day! EveryNote.com has been featured in The New York Times, Globe and Mail, Musical America and many other publications.
Tommaso Giordani
1738 - 1806
Tommaso Giordani short biography
Creator of one of the most popular songs, Caro mio ben, Tommaso Giordani moved to Dublin in 1764 and quickly became the major musician in the Irish capital. Giordani wrote many operas, an oratorio Isaac and immense quantity of overtures, sonatas, concertos, quartets and songs. Giordani was appointed organist at the Dublin's cathedral. Giordani was a conductor of his Te Deum at a ceremony for King George III. Giordani founded Rotunda concerts where John Field perform his Nocturnes.
More Songs sheet music download on EveryNote.com
Songs sheet music download on EveryNote.com
Web design by Web design SEO & Hosting Company - iGenii inc

subset: commoncrawl


text:
I made it because I was incensed by my grant being over a month late (I should get it by the end of this week). It's not one person's fault. It's not even, really, several people's fault. None of those involved did anything other than what they thought was right. But the systems are badly thought out, with a shocking lack of understanding between organisations.
This is a large part of why it was quite so frustrating; I couldn't focus my rage on a particular person but had to wade through layers of mistake-ridden bureaucracy (please note, if it had been one person's fault I wouldn't have stuck pins in them, just written a letter or ranted about them to my friends).
Hence the voodoo doll. It lets me materialise these systems and cultures and layers and layers and layers of mess-ups into one small, single entity who fits in my pocket. Better than that, it's anthropomorphised. It has a face, eyes and heart, all of which I can stick a needle through.
Please insert bitter and evil laugh here.


text:
Product Description
Sitting Cat is the original cat design - and one of four by Jin Designs. It is an ideal gift for cat lovers or for anyone who appreciates and loves cats. This 2 coaster set is made from melamine and has a non slip black felt backing.
The rectangle shape means you don't have to cover up the design with your mug, leaving Sitting Cat on view for you to enjoy.
The coasters are very durable and able to withstand temperatures of up to 140 degrees. They are easily wiped clean. No dishwashers please!
Collect the other delightful designs in the series too including Standing Cat, Sleeping Cat and Crouching Cat. Or enjoy all 4 designs in the Cat Coaster Set.
- Melamine coaster with black felt backing
- Part of the Sitting Cat Collection
- Wipe clean - not suitable for dishwashers
- 11.5cm x 9cm
- Made in the UK
Free UK Mainland Delivery on orders over £50.00
Standard UK Delivery - £2.95
Orders normally dispatched same day or next working day via Royal Mail 2nd Class who aim to deliver between 3 to 7 working days. This service is not tracked.
Tracked UK Delivery - £5.50
Orders normally dispatched same day or next working day via Royal Mail Tracked 24 who aim to deliver between 1 to 2 working days.
Next Day Delivery - £7.95
Available Monday to Thursday on all orders placed before 1pm.
Overseas Delivery available. Cost is confirmed at checkout.
See Delivery Details
Why Choose Jin Designs?
Why Choose Us?
Small Independent Business You Can Trust
Jin Designs has been trading online since 2013. We send orders out every day to customers across the UK and all over the world. As a small but growing business, we value our customers. When you make a purchase from us, we go to great lengths to make sure your experience is easy and one you are 100% satisfied with.
Fast and Efficient Delivery
When you place your order it goes direct to our experienced warehouse team who package it up and dispatch it to you within 24 hours of receipt. In fact, if you order by 1pm, your order will dispatch same day. There's also the option to choose Next Day Delivery. Each order is carefully wrapped to make sure your purchase arrives without damage.
Excellent Quality Items from Trusted Manufacturers
Standards are high here at Jin Designs and we will only work with suppliers who are able to produce high quality items. Once a design is created we work closely with the manufacturer to ensure it is brought to life on a beautifully clean and simple product.
Buy Direct from the Designer
All designs are created by Graphic Designer and Founder of Jin Designs, Jinny Ursell. When you make a purchase you're buying direct from the designer and supporting a small business who cares.
Excellent Customer Service
If you have any queries, whether it's before you order, or once your order has gone through, simply give us a call or email. Jin Designs has been voted 5 star "Excellent" from our customers via our Trusted Shops Reviews Page. No query is too small and if you need any advice or have a question on the products, please contact us.
Safe and Secure Payment Facilities
You can pay online through our secure checkout by using a debit or credit card via the WorldPay Gateway. Or choose PayPal who use the very latest SSL encryption technology. Your transaction is completely secure.


text:
VMware's new best friend. Tailor made for VMware environments, the HP t310 Zero Client delivers amazing processing power with the latest PCoIP VMware technology. Gain a seamless desktop experience, even with extensive multimedia. Reduce costs and free up desk space, while increasing security. With no moving parts, reliability is part of its DNA. Get to work fast with impressive boot and response times.
Electro-Magnetic Compatibility:


text:
This is a child theme of Zerif Lite.
ResponsiveBoat is a free responsive WordPress theme, with a friendly and colorful design. It comes with a full-screen layout, a full-width homepage header, elegant parallax effect, and nice animations. It can be used web agencies, digital studios, corporate, product showcase, personal and business portfolio. Overall, ResponsiveBoat looks very modern and interactive.
No themes found. Try a different search.


text:
Squarespace's mission is to provide creative tools that help anyone give a voice to their ideas. As a company that stands behind creativity in all forms, there's nothing that makes us more proud than seeing what our customers have created on our platform. Today, we'd like to put a call out to our customers to show us some of the stories we may be missing, with a chance that you'll be featured in one of our upcoming ads.
We currently run radio ads featuring longtime customers Dana Tanamachi and Parts and Labor on Spotify, Pandora, iTunes Radio, Sirius XM, and many of your favorite local AM and FM stations. Take a listen:
If you've got a beautiful Squarespace website and a story about how you took an idea and brought it to life, we'd love to give you a chance to appear in one of our new commercials. Here's all you've got to do:
- Record a 60-second audio clip about about what you do, what inspired you to pursue your idea, and how Squarespace helped bring it to life. (Please enunciate, don't speak too fast, and do your best to eliminate all background noise.)
- Be sure to include "I'm ___________, and I use Squarespace," or "We're ___________ and we use Squarespace," in your recording.
- Upload your audio file to SoundCloud. Be sure to tag it with #Squarespace and #CYOS.
- Post links to your SoundCloud file and your Squarespace website on Twitter or our Facebook page. Use the hashtag #CYOS and be sure to cc @Squarespace.
- All entries must be submitted by December 15, 2013.
At the beginning of January, we'll pick at least two customers to be featured in new radio ads. We are also going to throw in 12 free months of Squarespace to the winners as an extra thank you.
We can't wait to discover how you created your own space. Happy recording!


text:
DON/ZUG, Switzerland – Shareholders in Xstrata dealt a blow to their board on Tuesday, ushering through a long-awaited US$31-billion takeover by trader Glencore but vetoing a controversial executive pay plan that had been backed by the miner's directors.
The snub prompted Xstrata's current chairman John Bond, who will be chairman of the combined group, to announce he would step down once a replacement is found.
Tuesday's complex series of votes in the Swiss lakeside town of Zug, taking over more than two hours, brought to an end years of on-off merger talks between Xstrata and its largest shareholder and almost a year of often tense negotiations, creating what both sides hope will be a mining and trading powerhouse.
The tie-up, on the cards after Glencore listed last year, still needs to receive antitrust approval from European and Chinese regulators, but now looks set to become the largest deal in the sector since Rio Tinto's acquisition of Alcan in 2007.
Hours after Glencore's shareholders overwhelmingly backed the deal, almost 79% of Xstrata's voting shareholders gave their support — but without a "golden handcuffs" deal the board had insisted was key to keeping key managers.
The plan had been publicly lambasted by institutional investors.
Qatar, which became kingmaker in the deal as Xstrata's second-largest shareholder, had said it would back the main resolutions on the deal but would abstain on the retention, making it likely that vote would fail.
In the event, 78.4% of shareholders voted against pay awards described by one critical investor, activist fund Knight Vinke, as "egregious".
"Right now, there is US$20-billion of your money invested in 20 projects and extensions. It is the Xstrata management team that is responsible for making sure these investments are made safely, soundly and profitably," Bond told investors gathered for the votes.
But Bond, formerly chairman of Vodafone and HSBC, was brushed aside as shareholders threw out the pay plan. His resignation announcement came soon afterwards.
The deal is a victory for active investors, who secured change on both the terms of the deal, thanks to Qatar, and on the retention plan, initially a key condition for the deal.
Analysts and advisers have already begun focusing on the next steps for the miner and trader that, with its spread of assets from mines, to oil wells to farms and more ships than Britain's Royal Navy, is expected to be a deal machine in frugal times.
Xstrata, whose growth over the last decade has been fuelled by deals, was set up with a US$2.5-billion acquisition of Glencore coal assets. Glencore, for its part, joined the stock market last year with the intention of funding larger deals, including the bid for control of Xstrata.
"These companies have looked at doing significant acquisitions over the last year — the question is whether they buck the trend and provide more buoyancy in the industry," Alexander Keepin, partner and co-head of mining at law firm Berwin Leighton Paisner said.
Glencore and Xstrata have already proved a bright spot for the nine banks, law firms and countless other advisers, who will share some US$200-million as a result of one of the sector's largest deals since Rio Tinto's acquisition of Alcan in 2007.
Depending on the combined group's final weighting, Glencore Xstrata could be the 13th largest company in Britain's FTSE 100, representing more than 2% of the blue-chip index.
It could also sell some non-core assets — not least Xstrata's chrome and platinum, analysts say, and revise Xstrata's portfolio of mining projects, some of which are ambitious greenfield mines that Glencore does not prioritise.
Glencore, Xstrata's largest shareholder with a 34% stake, is offering 3.05 new shares for every Xstrata share.
Europe's antitrust regulators are due to give their verdict by Thursday.
© Thomson Reuters 2012


text:
Some commercial jets receive soaring fanfare when they hang up their wings.
Remember all that fuss over the Concorde?
Now it's the McDonnell Douglas DC-10's turn.
But what sort of retirement party awaits the airline industry's final scheduled DC-10 passenger flight?
The final-flight honor goes to Bangladesh Biman Airlines, operator of the world's last passenger DC-10 which the airline says will be making its final scheduled flight on December 7, on an otherwise routine flight. (The airline hasn't said which route the plane will fly.)
The aircraft will then remain grounded in standby mode while awaiting the arrival of its successor, a shiny new Boeing B777-300ER and eventual shipment to an undisclosed aviation museum in the United States.
While passenger service comes to an end for the iconic, wide-body, three-engine workhorse of late-20th-century air travel, the DC-10 won't completely disappear from the skies.
It's still commonly used by cargo companies, such as FedEx and Purolator.
Last chance for 'genuine aviation enthusiasts' to fly DC-10
For DC-10 fans (we know you're out there) mourning the end of an era, Biman has since announced one last chance to experience the DC-10 in action — even if you're not a box with an overnight label.
In February 2014, Biman Bangladesh Airlines plans to fly passengers from the Bangladesh capital of Dhaka to Birmingham, England, on its retired DC-10, one last time.
It's "a fitting end for an aircraft that has served Biman loyally and well over many years," states the airline, which plans to start selling tickets for this special bonus voyage on its website by early January.
"We want these tickets to go to genuine aviation enthusiasts," says Biman CEO Kevin Steele on the company's news page, adding that some short scenic flights out of Birmingham might also be added to the DC-10 farewell tour, depending on public demand.
What's the projected demand? No word on that yet.
DC-10's checkered history
McDonnell Douglas's famous (and at times infamous) jetliner logged its maiden voyage for passengers on August 5, 1971, on an American Airlines round trip between Los Angeles and Chicago.
At the time, the plane filled an industry need for an innovative aircraft smaller than a 747 with long-range capabilities that could serve airports with shorter runways.
A staple of several major airlines over four decades — McDonnell Douglas produced its 446th, and last, DC-10 in 1989 for Nigeria Airways — the aircraft would be hampered by tragic accidents, including a horrific American Airlines Flight 191 crash at Chicago's O'Hare International Airport in 1979 resulting from a separated engine ripping through a wing shortly after takeoff.
The incident would lead to an FAA grounding of all DC-10s in the United States for more than a month and stoke widespread public fear about the DC-10 — despite findings that a maintenance error was largely the cause.
More: Skip the pasta! And other unsavory truths about airplane food
Though few major DC-10 incidents were actually due to mechanical issues alone, and the aircraft's safety record would steadily improve as design flaws were fixed, public confidence in the aircraft was never fully restored.
Wired magazine would call the DC-10 the fifth worst "stupid engineering mistake" in history.
Others called that label unfair.
"The DC-10 had its share of high-profile accidents," noted a Los Angeles Times editorial in 2007, when Northwest Airlines became the last major carrier to retire it from passenger service in the United States — replacing it with an Airbus 330. "But so have the much-less-maligned Boeing 737 and 747, the latter of which has a fatal-accident rate close to the DC-10's."
Economics factor in retirement
A more significant factor behind the DC-10 retirement wave relates to fuel efficiency and cost.
Newer aircraft use less fuel, making DC-10s a more expensive airliner to operate.
It also requires a three-man crew, including a second officer or flight engineer — an overhead-boosting rarity these days.
Even if today's harried commercial passengers aren't exactly missing DC-10s (let alone knowing what makes one different than, say, an MD-11), some of its past pilots have nice things to say about them.
"The DC-10 is a reliable airplane, fun to fly, roomy and quiet. Kind of like flying an old Cadillac Fleetwood," noted a spokesman for the Northwest chapter of the Air Line Pilots Association when the planes were shelved in the United States six years ago. "We're sad to see an old friend go."
Cut to 2013.
Who would have thought the last flying Cadillac Fleetwood would be making its swan song from Bangladesh?
And just how sad is Biman Bangladesh Airlines to see an old friend go?
"We hope you will join with us in celebrating the farewell of a loyal, beautiful aircraft," says Biman's Steele. "But also to recognize that the time has now come for Biman to equip itself with the very latest in new aircraft and technology."
By Jordan Rane, for CNN
Photo from CNN.COM
This is a non-commercial excerpt from CNN.COM
to read more please visit:


text:
This page describes internship opportunities in the field of computer forensics. Please feel free to add your own.
By Chet Uber, March 8, 2007
In the Nebraska Cyber Crime Task Force and issue arose which stopped college students from being allowed to work as interns and this was that they do not have the formal training that official forensic officers do; and can damage critical evidence. This was a valid comment by the director of the State Patrol's Forensic Lab. A number of is in the room ran through ways to do away with this potential problem (please note this is not at all related to releasing confidential information, but rather the destruction of the original foresnic evidence.
The disk is duplicated, and the duplicate is given to the Universities Forensic Lab Manager, who assigns cases. The intern then performs forensics and records offsets, or other methods to form a "recipe" to find what they found. This receipe can then be passed back to Law Enforcement and they can recreate the examination. This method saves LE a lot of time, and gives good experience to not just one student intern, but can be given to many interns. For more information on this novel solution contact:
Dr. Blaine Burnham (firstname.lastname@example.com) Executive Director, Nebraska University Consortium on Information Assurance
Dr. Burnham is the Director of NUCIA and a Senior Research Fellow for the College of Information Science and Technology. Most recently, he was the Director of the Georgia Tech Information Security Center. Previously, Burnham worked in a variety of information assurance roles at the National Security Agency (NSA), Los Alamos National Laboratory, and Sandia Laboratory.
To see the top class labs that are available at this institution see:
1. Check out this page: http://www.rit.edu/~gtfsbi/forensics/internships.htm it has a load of internships although all are not stipend paying 2. Internet Crimes Against Children. ICAC has offices in almost every state. 3. Check with companies that do computer forensics. Examples include Kroll and Pinkerton. 4. Explore the Scholarship for Service and Scholarship for Work programs offered by the US Government.
Vermont ICAC (Internet Crimes Against Children). http://www.vtspecialcrimes.org/
Vermont State Patrol. They are almost always understaffed, and may have suggestions working with Counties and Cities. It requires a that you are not a felon and can pass a 7-year background check -- but a lot of places are so backlogged they are putting on reserve deputies to work cyber crime. http://www.dps.state.vt.us/vtsp/bci.html


text:
The New York Times on Wednesday published definitive proof that the White House used Internal Revenue Service audits to punish its political enemies -- in 1971.
An obituary of Randolph Thrower, who was commissioner of internal revenue under President Nixon from April 1, 1969 to June 22, 1971, notes that he helped draft the 1969 Tax Reform Act and pushed to revoke the tax-exempt status of private schools that excluded African Americans.
But Thrower was fired in 1971 after he requested an appointment with the president to warn him that White House staffers were pressuring the IRS to audit the tax returns of anti-Vietnam war leaders, civil rights activists, journalists and Democratic members of Congress. Not only did Thrower not get his top-level meeting, he soon got a call from Nixon domestic affairs adviser John Ehrlichman giving him the ax.
The public was told Thrower resigned "for personal reasons." But as the celebrated memos and secret tapes of Nixon's conversations would later show, the president wrote on Jan. 21, 1971, "May I simply reiterate for the record that I wish Randolph Thrower, commissioner of the Internal Revenue Service, removed at the earliest feasible opportunity." And during the subsequent search for a successor, Nixon said, "I want to be sure he is a ruthless son of a bitch, … that he will do what he is told, that every income tax return I want to see, I see" and "that he will go after our enemies and not go after our friends."


text:
Accessibility tools
Service tools
Language selector
Navigation path
Left navigation
Additional tools
Other available languages: none
European Commission
Olli REHN
Vice-President of the European Commission and member of the Commission responsible for Economic and Monetary Affairs and the Euro
Statement on Cyprus in the European Parliament
European Parliament Strasbourg
17 April 2013
President, Honourable Members,
As President Barroso is attending the funeral of Baroness Thatcher today, I am presenting the Commission's views in this important debate together with my colleagues Joaquin Almunia and Michel Barnier, with whom we have worked very closely as a team in the past years.
We are about to finalise a support programme for Cyprus. It will enable Cyprus to avoid a disorderly default with all its dramatic ramifications for the Cypriot people. This marks the beginning of a joint effort to bring Cyprus onto the path of sustainable growth and job creation.
The process that led us to this agreement has been very difficult, and not without mistakes. The Cypriot authorities, the Member States and the EU Institutions had to find unique solutions to exceptional problems. They had to do so without previously tested instruments and – in the final stages of negotiations – under enormous time pressure.
Thus, there are at least two key lessons to be learnt from this difficult process. First, there must be absolute clarity about secured deposits. In this respect, the Eurogroup and Cyprus took rapid corrective action and underlined that secured deposits indeed are secured in Europe.
Second, the developments in Cyprus demonstrate the reasons why a Banking Union is a necessary element of a true EMU. We need a well-functioning Single Supervisory Mechanism with a single rulebook to prevent the emergence of an unsustainable banking sector like in Cyprus. And we must ensure that even if the reinforced supervision fails, we have a Single Resolution Mechanism to provide the instruments for a timely and effective restructuring and resolution of the problem banks.
But these instruments are not yet there, and in this process we had to work with the less sufficient ones that we have today.
The problems of Cyprus built up over many years. At their heart was an oversized banking sector that thrived on attracting foreign deposits with very favourable conditions. These capital inflows also contributed to a property boom and the accumulation of external imbalances.
The depth of banking problems stemmed from the poor practices of risk management. Lacking adequate oversight, the two largest Cypriot banks were allowed to build up by far too concentrated risk exposures. It was the problems in these banks that caused the troubles for the sovereign and the economic decline of Cyprus – not the other way round.
The Commission had alerted Cyprus on its problems early on. Warnings and policy guidance were included in the reports and Country-Specific Recommendations under the first European Semester in May 2011.
Then, in November 2011, we communicated to the Cypriot authorities that a financial assistance programme would be unavoidable, unless the persistent economic problems were immediately addressed.
Eventually, Cyprus asked for financial assistance, but only in June 2012. After half a year of talks, a staff-level agreement on the necessary structural reforms and fiscal measures was reached. Many of them, including anti-money laundering measures, were adopted by the Cypriot Parliament before the end of 2012.
The Commission's goal during the whole process of agreeing a support programme for Cyprus has been three-fold: to help Cyprus to the path of sustainable growth, to preserve financial stability in Cyprus and in the eurozone and to protect the integrity of the euro and the single market.
The Commission's preferred scenario was a more gradual adjustment of the Cypriot banking system and real economy, while ensuring debt sustainability.
However, there was a very firm financial constraint. The euro area member states were ready to commit official support up to 10 billion euros, whereas the total financing needs had been estimated at 17 billion euros. This constraint severely limited the options available.
As the time was running out, the scenario of the more gradual economic adjustment was not on the cards anymore. The state of banks deteriorated rapidly. Soon it became clear that the second biggest bank, Laiki, had to be resolved immediately. The risk of a complete collapse of the entire banking system – and thus a sweeping loss of deposits and savings and a disorderly default of the sovereign – was indeed very real. That would have been a disaster to Cyprus and to the Cypriots.
Without a bank resolution law and without a programme in place, banks remained closed and the bank holidays were extended. The Cypriot authorities imposed capital controls to avoid the flight of deposits.
The Commission, as the guardian of the Treaties, is closely monitoring the impact of capital controls in Cyprus. The temporary restrictions were justified in the given circumstances, but they are a very serious limitation to the free movement of capital. Therefore, the Commission will ensure that these measures last no longer than strictly necessary.
President, Honourable members,
The support programme will enable Cyprus to restore the health of the economy and to create a more sustainable economic model. The loans of up to 10 billion euros equal to more than half of Cypriot GDP.
I agree with the Minister of Finance of Cyprus, Haris Georgiades, who said yesterday that he wants to shun the blame game and focus on the future. He said as follows: "We are determined to adopt and implement all those reform measures, which we should have adopted a long time ago, but we failed to do so".
Indeed, we now have to concentrate all our efforts to facilitate the emergence of new sources of economic activity and to alleviate the social consequences of the economic shock.
The Commission decided on the 27 of March to set up a Support Group for Cyprus with the implementation of the adjustment programme. The Commission is now mobilising its resources to provide technical assistance. The Support Group will rely on expertise from across the Commission services. An immediate priority is to identify the relevant resources available from the current structural funds.
The Commission stands by the Cypriot people in this time of deep trouble. We are committed to help Cyprus to get through the tough times and overcome the current difficulties. I trust that we can count on the support of the European Parliament in together mobilising the available resources for Cyprus, as quickly and as effectively as possible.
I am looking forward to a constructive dialogue on the matter.
Thank you for your attention.
Side Bar


text:
Meet Carmen Pereida, Employee of the Month
As program coordinator for Cooperative Education, successfully working with students, faculty, classified staff and administrators is second nature for Carmen Pereida.
"One of the reasons I really like my job is because it provides me the forum to do what I love to do," says Pereida. "Students energize me. When we explore career options and they finally make the connection between school and work, I see the sparkle in their eyes and their minds expanding to new possibilities."
Prior to coming to De Anza in 1993, Pereida worked at the Middlefield Campus as a registration supervisor. Her nominator, Paula Ahrens, says, "Carmen is amazing. She has single-handedly run all facets of Cooperative Education for years, and adapts and overcomes regardless of the obstacle." Ahrens says Pereida's work provides a significant amount of WSCH to instruction each quarter.
Pereida also enjoys serving on committees and likes the outcome of the collaborative decisions they make. "I've been involved in the Latina/o Student Recognition Committee and together we've raised more than $25,000 for student scholarships." Pereida has also served as a Classified Senator for two years.
"Working at De Anza has allowed me to explore and expand my analytical perspectives and express my artistic side," she says.


text:
So I'll be traveling out from Cleveland to LA for the first time to attend PWG's Battle of Los Angeles. I'd like to extend the possibility of putting together some sort of meet up for anyone else attending the pair of shows, whether it's long-time PWG attendees, or others traveling from outside the area. I'll be staying at the Howard Johnson in Reseda, which I believe is as close as you can get to the American Legion Post venue. Point of the meet up is to hang out with fellow fans, share stories, and to create fun times.
Would anyone here be interested in this meet up? Details of the meet-up will come later once we can figure out a mutual place for all to meet at.


text:
UCLA vs. ARIZONA STATE, Rose Bowl, Saturday, 4 p.m.
Game over. Everyone take a knee. No, this time, just you Stan McKay. The YouTube.com clip of the week showed the Bruins senior linebacker out of Long Beach Poly High seizing the moment after last Friday's win over Washington to ask his girlfriend to marry him at midfield, with teammates and coaches around him capturing it on video. Her touchdown signal appeared to make things official. Here's a new proposal: Should the Bruins untie the knot with the Sun Devils in the Pac-12 South by putting up a victory against them here, could someone figure out any better how everyone's postseason bowl bids fall into place? Doubtful. Still one more week after this one. A Sun Devils victory would drop UCLA to three conference losses. A Bruins victory means the Sun Devils could still win it if they beat Arizona and USC knocks out UCLA. ASU has lost two in a row to UCLA, but the losses are a by a combined three points. A field goal on the last play of the game gave the Bruins a 45-43 win last year. A Sun Devils' missed field goal on the last play of the game gave the Bruins a 29-28 win in 2011.
USC at COLORADO, Saturday, 6:30 p.m.
The Trojans' euphoria over Saturday's triumph over Stanford, and with plans on meeting up with UCLA on the Saturday after Thanksgiving, gives a moment to pause that this trip to Folsom Field in Boulder, Colo., won't be a giant Buff trap. Colorado is also riding a huge wave of momentum: It racked up its first conference win last week against Cal.
CLIPPERS at OKLAHOMA CITY, Thursday at 5 p.m., TNT
In the playoff-type atmosphere last week at Staples Center — complete with a couple of ejections for seemingly innocuous pushing and shoving — the Clippers somehow prevailed. National attention is back on this one, with Charles Barkley recruited as an on-site game analyst.
Other key games this week: Clippers vs. Chicago, Staples Center, Sunday at 12:30 p.m., Prime
LAKERS vs. GOLDEN STATE, Staples Center, Friday at 7:30 p.m., ESPN, TWC SportsNet
Now if this is the week to anticipate Kobe Bryant's return, a lot could depend on this four-day stretch of practices he'll have. Just hope he doesn't have to guard Klay Thompson. Last time the Lakers saw him with the ball, it was a career-best 38 points in a 31-point win. Not even his dad in the Lakers' broadcast booth could find fault with him that Halloween night.
Also this week: Lakers vs. Sacramento, Staples Center, Sunday at 6:30 p.m., TWC SportsNet
KINGS vs. NEW JERSEY, Staples Center, Thursday at 7:30 p.m., FSW
Come to see if Kings goalie Ben Scrivens can shut out the Devils twice in a week. Stick around to see if Jaromir Jagr can stay on his pace to register 65 points this season — he turns 42 early next year.
Other key games this week: Kings vs. Colorado, Staples Center, Saturday at 7:30 p.m., FSW
UCLA vs. SACRAMENTO STATE, Pauley Pavilion, today at 8 p.m., Pac-12 Network:
Bruins senior Travis Wear, who had an appendectomy at the UCLA Medical Center three weeks ago, remains questionable for tonight's game. Our question: What if Travis' twin brother David just wore No. 24 and suited up in his place?
Also this week: UCLA vs. Morehead State, Pauley Pavilion, Friday at 8 p.m., Pac-12 Network; UCLA vs. Chattanooga, Pauley Pavilion, Sunday at 7 p.m., Pac-12 Network
USC vs. CAL STATE FULLERTON, Galen Center, Tuesday at 8 p.m., Pac-12 Network
Titans senior guard Michael Williams is the elephant in the room — can the former Daily News player of the year at Taft High, now eligible after a transfer following three years at the University of San Francisco, make a difference against the Trojans?
Also this week: USC vs. Western Alabama, Galen Center, Thursday at 7 p.m., Pac-12 Network
MANNY PACQUIAO vs. BRANDON RIOS, WBO International welterweight title, Saturday at 6 p.m., HBO pay per view, $69.95:
Trainer Freddie Roach has already said this about Pacquiao: "(If this fight) does not go well, we will seriously talk about his retirement." The 34-year-old Filipino (54-5-2, 38 KOs) comes off back-to-back losses to Juan Manuel Marquez (Dec., 2012) and Timothy Bradley (June, 2012). But most disconcerting to Pacquiao is his connection to fans who have been through the recent devastation of Typhoon Haiyan in the Philippines. Another compelling reason to watch is the venue: The Venetian Hotel in Macau, China. Pacquiao hasn't fought outside the U.S. since 2006. The Oxnard-based Rios (31-1-1, 22 KOs) lost his last bout to Mike Alvarado last March.
L.A. GRAND PRIX, The Velo Sports Center at Cal State Dominguez Hills, Friday-Sunday:
Back at the site where cycling was contested at the 1984 Olympics nearly 30 years ago, racers from nearly a dozen countries are on track to collect more points toward qualifying for the UCI World Cup next month. The field includes six-time world champ Sarah Hammer, born in Redondo Beach and raised in Temecula, winner of two silver medals at the 2012 London Olympics (part of the U.S. women's team pursuit and in the women's six-event omnium). There are two sessions each day: Friday (11 a.m. and 6:30 p.m.), Saturday (9 a.m. and 6:30 p.m.) and Sunday (9 a.m. and 3 p.m.)


text:
Willow Creek unveils multi-faceted Care Center to help those in need
Willow Creek Community Church unveiled its new $10 million Care Center Friday in South Barrington, and the size and scope of the building left visitors amazed.
After years of planning, church officials moved their former food pantry and social service ministries just three miles from a Hoffman Estates location, but the gleaming new layout seems worlds away.
The 60,000 square feet of space on the southwest corner of the campus will open for business at 10 a.m. Monday. Tours will be given during an open house after the 5:30 p.m. service today and after Sunday morning services.
"After the recession hit in 2007 and 2008, we saw a more than 300 percent increase in the number of guests needing our services," said the Rev. Bill Hybels, pastor and founder of Willow Creek. "We knew we needed to make a bold move and declare our commitment not just to their spiritual life, but have a holistic approach to meeting their physical and material needs as well."
The expanded services housed in the new make it one of the nation's largest all-encompassing church outreach operations under one roof, officials say. The church had more than 2,000 volunteers lined up to staff it.
"We're passionate about the depth of care we're offering," says Heather Larson, Willow Creek's director of compassion and justice. "We wanted to do more than assist families in the community with grocery bags of food."
At its former Hoffman Estates facility, the church served more than 17,000 families last year. Church officials expect the new center to draw even more people, but underlying their care, officials say, will be dignity and a sense of value.
That becomes apparent with the center's new look. The main level opens up like a marketplace, complete with a children's clothing store -- stocked with gently used items -- and a food pantry styled like a full-choice grocery store.
The CARS ministry -- an acronym for Christian Auto Repairmen Serving -- is located behind the food pantry, as is a giant warehouse for the more than 4 million pounds of food.
The guest waiting area offers brightly colored furniture pods and conversation groupings, as well as computer stations. A Kids' Zone will tantalize children with play equipment and toys. Dental and optometry clinics will offer on-site care.
Hybels said bringing the Care Center on campus had a twofold goal: offering guests access to services meeting their spiritual and material needs and connecting church members with marginalized families living around them.
"I hope they gain a better understanding of the complexities of suburban poverty," Hybels said, "and involve themselves in the ministries here."


text:
Loading Map....
Brewery tour including beer tasting, and a sample of our Bierschnaps
Date(s) - 03/03/2017
4:00 pm - 5:00 pm
Mill Street Brew Pub Toronto
Tours include a tour of the brewery and still, a tutored beer flight tasting, and a sample of our Bierschnaps. For the "DD" or Under 19, the sample is replaced with a souvenir Mill St. glass & bottle opener.
Please call 416.681.0338 ext. 4 to make a Brewery Tour reservation.
Brewery Tours:
Monday – Friday 4PM
Weekends & Holidays 1PM, 3PM, 5PM


text:
To serve the growing number of baby boomers approaching retirement, economists, educators, financial advisers and (of course) journalists are pumping out a steady stream of articles about Social Security and when to claim benefits. One recent entry can be found in the current issue of the Journal of Financial Planning, under the title "When to Start Collecting Social Security Benefits: A Break-Even Analysis." The article is geared primarily toward financial advisers – but it's also a great primer for individuals who are beginning to wrestle with this critical decision.
The author is Doug Lemons, a former senior official in the Social Security Administration. His focus is on figuring out "break-even" points—the age at which total Social Security income from two retirement-timing options is the same. This is another way of looking at the issue that bedevils many would-be retirees: Will I maximize my payouts by claiming Social Security early and collecting smaller paychecks for a longer period of time, or should I wait and begin collecting larger paychecks in the future? The earlier your break-even age is, the more theoretically likely it is that collecting early will work against you in the long run, since you'll need to live longer on a smaller paycheck.
In some respects, the math is simple: Social Security calculates your benefit so that, whether you start collecting early or late, you will – at least in theory, based on life expectancy – receive about the same total payout over your lifetime. (The Social Security Administration itself can help walk you through possible scenarios with its "Retirement Planner.")
Lemons, for his part, looks at three basic options: collecting benefits at age 62 (the earliest age possible for most individuals); full retirement age (which he pegs at 66); and age 70. (You can maximize your monthly check by waiting until age 70 to claim benefits, but you won't gain anything by delaying beyond that point.) These options, moreover, don't occur in a vacuum, either in real life or Lemons's research—he factors in variables including inflation rates, return on investment and marginal tax rates.
His findings underscore the idea that collecting earlier, and getting a smaller paycheck, puts more strain on your other sources of retirement income. For example: For an individual worker who isn't affected by Social Security's "earnings test" (under which benefits are reduced above certain income levels), returns on investments "must generally exceed the rate of inflation by 5% or more to justify taking benefits at age 62 rather than at full retirement age." For some, that could be a high bar to clear.
To learn more, see the full article here.


text:
My Account
Contact Us
About Our Store
News & Features
Reference Room
Health Calculators
Conditions & Allergies
Health & Wellness
Vitamins & Minerals
Functional Foods
Children's Health
Adolescent's Health
Women's Health
Men's Health
Senior's Health
Healthy Recipes
Ingredient Glossary
Delicious Living
Cone's Links
Table of Contents
> Nephrogenic diabetes insipidus
Nephrogenic diabetes insipidus
Related Terms
Signs and symptoms
Integrative therapies
Author information
Risk factors
Types of the disease
Integrative Therapy Quick Links:
Low sodium diet
Psychomotor therapy, physical therapy
Related Terms
Acquired nephrogenic diabetes insipidus, ADH-resistant diabetes insipidus, arginine vasopressin, AVP, diabetes insipidus renalis, hyperchloremia, hypernatremia, NDI, polydipsia, polyuria, vasopressin-resistant diabetes insipidus.
Nephrogenic diabetes insipidus (NDI) is a rare disorder that is caused by large amounts of dilute urine produced by the nephrons, which are found in the kidneys. Normally, the kidneys control the concentration of the urine by absorbing water and returning it to the blood in response to the body's need for water. In a healthy person, an antidiuretic (urine-limiting) hormone called arginine vasopressin (AVP) sends a signal to the kidneys to control the concentration of urine. In patients with NDI, the kidneys are unable to respond to AVP, which causes a problem with water retention. A substantial amount of water that is needed by the body is lost in large quantities as dilute urine. This leaves NDI patients continuously thirsty and in danger of dehydration.
NDI may be either acquired or inherited. Acquired NDI is more common and is usually caused by certain drugs, severe dehydration, or an electrolyte imbalance, such as elevated sodium or chlorine levels in the blood. Inherited NDI is caused by defects in the
genes. NDI can be inherited in an X-linked or an autosomal fashion. X-linked mutations are carried on the X chromosome, which is one of the two sex chromosomes. Females have two X chromosomes, whereas males have one X and one Y chromosome. Males are most likely to have symptoms of inherited X-linked NDI because they receive only one X chromosome, compared to females who inherit two X chromosomes. Autosomal mutations are located on one of the 22 non-sex chromosomes. Males and females are equally likely to display symptoms of the autosomal forms of inherited NDI because this form of the disorder is not linked to a sex chromosome.
Symptoms of NDI include extreme thirst (polydipsia), excessive urination (polyuria), short stature, and a failure to develop during infancy. NDI patients require a steady supply of water to alleviate their thirst and to prevent dehydration. With early diagnosis and proper management, the quality and duration of life can be normal for patients with NDI.
NDI is different from diabetes mellitus, which involves problems with insulin and blood sugar regulation. The symptoms can be similar and may include extreme thirst and frequent urination. However, NDI is related to how the kidneys handle fluids. Urine and blood tests can determine if a patient has NDI or diabetes mellitus.
Signs and symptoms
: The main symptoms of nephrogenic diabetes insipidus (NDI) are extreme thirst (polydipsia) and excretion of large amounts of dilute urine (polyuria). The symptoms are similar for both the acquired and the inherited forms of the disease. When NDI is inherited, these symptoms appear at birth and are usually diagnosed before one year of age. When the condition is acquired, symptoms may not occur until adulthood.
Inherited NDI
: Infants born with NDI may become dehydrated if they do not receive enough fluids to replace the water lost through the urine. If left untreated, NDI can cause brain damage and stunted growth. Symptoms in infants may include poor feeding and development, rapid onset of severe dehydration, and a swollen bladder caused by the high urine volume. Some infants also have vomiting, gagging, constipation or diarrhea, unexplained fevers, weakness, and irritability.
Acquired NDI
: The initial symptoms of acquired NDI may include rapid onset of severe dehydration, vomiting, diarrhea, fever, seizures, or coma. Other symptoms may include a swollen kidney (hydronephrosis), a swollen ureter (hydroureter), and an abnormally large bladder (megalocystis). If a person has normal thirst mechanisms and drinks enough fluids, NDI may have no significant effects on the fluid and electrolyte balance of the body. If the person does not drink enough fluids, the high urine output may cause high blood sodium levels, dry skin, sunken eyes, fatigue, headache, irritability, low body temperature, muscle pains, rapid heart rate, weight loss, and shock.
: Nephrogenic diabetes insipidus (NDI) should be considered in people with polyuria (excessive urine production) and/or polydipsia (excessive thirst). Blood and urine tests are performed to test for abnormal levels of water, sodium, and arginine vasopressin (AVP).
Blood test
: Blood is tested for sodium levels and plasma concentration, which is the ratio of plasma solutes to plasma solvent. Increased blood sodium or blood plasma concentration indicate NDI.
Urine test
: Because output of a large volume of dilute urine is the main symptom of NDI, many types of urine testing are performed when diagnosing NDI. These include testing the total amount of urine produced in a 24-hour period and the concentration of the urine, which is measured by testing the urine specific gravity. In patients with NDI, the volume of urine is higher than normal, and the urine has a low concentration and specific gravity. Although an overnight urinary concentration test in female relatives has been proposed as a method of carrier detection, it has been proven unreliable. Failure to concentrate the urine normally in the presence of high blood AVP levels or when given desmopressin (DDAVP), a synthetic antidiuretic hormone, indicates NDI.
Water deprivation test
: Patients with NDI tend to produce urine that has a low concentration despite being deprived of water. On administration of AVP, patients with NDI will show little or no increase in urine concentration. During the water deprivation test, the patient is carefully monitored to make sure his or her body weight and blood plasma concentration stay within a safe range. The patient goes without water for less than six hours while the blood plasma concentrations and urine volume are measured. If the patient has NDI, he or she will be resistant to the antidiuretic action of AVP. Immediately following the water deprivation period, a patient with NDI will still have concentrated blood plasma and dilute urine despite the fact that he or she will be fairly dehydrated at that point. At the end of the water fast, the patient's response to an infusion of DDAVP is measured. If the patient does not respond to DDAVP, he or she may have NDI. If the patient shows highly concentrated urine in response to DDAVP, he or she may have a different form of diabetes insipidus called pituitary diabetes insipidus, which is also called central or neurogenic diabetes insipidus. Following DDAVP administration, a patient with NDI caused by a mutant
gene will display an increased heart rate and blood pressure, whereas the patient who has NDI caused by a mutated
gene will not.
: An ultrasound may be performed to examine for swelling of the kidney, the urinary tract, and the bladder to establish the extent of disease in an individual diagnosed with NDI. Some degree of urinary tract swelling may be seen on ultrasound examination even in infants.
DNA test
: If a person has a family history of NDI, a sample of the patient's blood is analyzed in a laboratory for the mutated
genes. If a mutation is present, a positive diagnosis is made. Although a carrier does not have NDI disease, he or she may pass a copy of the mutated gene to his or her children. Molecular genetic testing of the
gene detects approximately 95% of disease-causing mutations in individuals with X-linked NDI. Molecular genetic testing of the
gene detects about 95% of disease-causing mutations in individuals with autosomal recessive NDI.
: Rapid and severe dehydration occurs when not enough water is consumed to make up for water lost in the urine. If this happens rapidly or if it is present for a long time, permanent brain damage and poor growth may occur. Dehydrated individuals may be treated with intravenous (IV) administration of normal saline, especially in emergency situations. However, saline infusion may elevate sodium in the blood to dangerous levels. Repeated or prolonged episodes of severe dehydration may result in seizures, shock, developmental delay, mental decline, and death.
Urinary tract swelling
: The large and constant flow of urine over many years can expand the urinary tract and the bladder. This may cause a variety of potential problems, including rupture of the urinary tract, infection, pain, improper bladder function, and/or kidney failure. In addition, reversible NDI may progress to irreversible NDI in these patients.
: There is currently no known cure for nephrogenic diabetes insipidus (NDI). Treatment involves preventing dehydration by drinking water on a regular basis and especially at the first signs of thirst. In infants and children who may not readily communicate their thirst, water must be offered frequently, even during the night. Reducing or stopping medications that can cause NDI may improve symptoms. Friends, teachers, and neighbors should be educated about the condition. Infants and children should be monitored for abnormal growth and blood sodium concentrations and should have a yearly ultrasound evaluation to monitor for a swollen urinary tract. Continuous or intermittent bladder catheterization may be necessary when the bladder does not completely empty on its own.
Intravenous (IV) hydration
: Healthcare providers generally treat dehydration with normal saline, which can be dangerous to individuals with NDI because of the sodium content. Acute blood loss or shock may be treated with isotonic fluid until the blood pressure and heart rate are stabilized, after which 2.5% dextrose in water is the preferred solution. Whenever possible, rehydration should occur through drinking water.
: The goal of treatment is to regulate fluid levels in the body. Treatment should involve regular intake of a high volume of fluid. The volume of fluids consumed should be about equal to the volume of urine produced.
Lifestyle changes
: NDI patients require constant access to drinking water and toilet facilities, which may disrupt school and other social or group activities.
Patients with NDI are advised to adopt a low-sodium diet. A low-sodium diet maximizes the effectiveness of thiazide diuretics in reducing urine output. Although previously a diet low in protein was recommended for NDI patients, severe limitation of dietary protein may introduce nutritional deficiencies.
: Thiazide (hydrochlorothiazide and chlorothiazide) and amiloride diuretics deplete total body salt, allowing the kidneys to more readily absorb water and decrease urine output. This improved water absorption can be reversed by consuming a high-salt diet. Therefore, low-sodium diets are prescribed for NDI patients. Thiazide diuretics may also deplete the body's stores of potassium. When taking thiazide diuretics, the patient's potassium levels must be monitored. To maintain sufficient potassium in the body, the addition of potassium supplements may be required. Combining a thiazide diuretic with a potassium-sparing diuretic (such as amiloride) may be more effective than using a thiazide alone. Sometimes thiazides are used in combination with the prostaglandin inhibitor, indomethacin, which treats pain.
Acquired NDI may be caused by taking lithium. Thiazide diuretics should be used with care in cases of lithium-induced NDI because they reduce the degree to which the kidney can excrete lithium. Amiloride is more widely used in these cases because it inhibits the accumulation of lithium while blunting lithium's inhibiting action on water reabsorption.
Nonsteroidal anti-inflammatory drugs (NSAIDs)
: NSAIDS, such as indomethacin, are often prescribed to improve the ability to concentrate urine and to reduce urine output in individuals with NDI. NSAIDs have been used individually and in combination with thiazide diuretics (with or without amiloride). Because NSAIDs have undesirable effects, such as gastric and renal tubular damage, and because the incidence of complications has not been studied in individuals with NDI, caution is warranted in the chronic use of NSAIDs for treatment of NDI. Indomethacin often causes headaches and dizziness and may increase the risk of gastrointestinal disorders. If administered in the first year of life, indomethacin increases the risk of kidney disease.
Integrative therapies
Traditional or theoretical uses lacking sufficient evidence
Low sodium diet
: Patients with nephrogenic diabetes insipidus (NDI) are advised to adopt a low-sodium diet. A low-sodium diet maximizes the effectiveness of thiazide diuretics in reducing urine output. Although previously a diet low in protein was recommended for NDI patients, severe limitation of dietary protein may introduce nutritional deficiencies.
Psychomotor therapy, physical therapy
: Children with a history of severe dehydration, delayed development, or a delay in establishing the correct diagnosis and management of NDI should be considered for behavioral and physical therapy before school age.
: Prevention of nephrogenic diabetes insipidus (NDI) includes taking measures such as drinking water on a regular basis and especially at the first signs of thirst. In infants and children who may not communicate their thirst, water must be offered frequently, even during the night. Medications that could cause acquired NDI should be avoided in families at risk for the disease. Friends, teachers, and neighbors should be educated about the condition. Infants and children should be monitored for abnormal growth and blood sodium concentrations and should have a yearly ultrasound evaluation to monitor for a swollen urinary tract to prevent symptom development.
Genetic testing
: Genetic testing may be performed to determine if a person carries the mutated genes that cause NDI. Although carriers do not have the disease, they may pass a copy of their mutated genes to their children. Genetic testing of children or newborns with NDI symptoms is valuable because early diagnosis and treatment can prevent the physical and mental decline associated with repeated episodes of dehydration.
Prenatal DNA testing may be performed if there is a family history of NDI. However, there are health risks associated with prenatal testing, including miscarriage. Therefore, patients should discuss the potential health risks and benefits with their healthcare provider before making any health-related decisions. A genetic counselor can also explain the different types of genetic tests, including their potential risks and benefits. These counselors can help patients understand the results and limitations of these tests.
Author information
This information has been edited and peer-reviewed by contributors to the Natural Standard Research Collaboration (www.naturalstandard.com).
Bichet DG. Nephrogenic diabetes insipidus. Adv Chronic Kidney Dis. 2006 Apr;13(2):96-104.
Garofeanu CG, Weir M, Rosas-Arellano MP, et al. Causes of reversible nephrogenic diabetes insipidus: a systematic review. Am J Kidney Dis. 2005 Apr;45(4):626-37.
Khanna A. Acquired nephrogenic diabetes insipidus. Semin Nephrol. 2006 May;26(3):244-8.
Majzoub JA, Srivatsa A. Diabetes insipidus: clinical and basic aspects. Pediatr Endocrinol Rev. 2006 Dec;4 Suppl 1:60-5.
Makaryus AN, McFarlane SI. Diabetes insipidus: diagnosis and treatment of a complex disease. Cleve Clin J Med. 2006 Jan;73(1):65-71.
Natural Standard: The Authority on Integrative Medicine. .
NDI Foundation. .
Online Mendelian Inheritance in Man (OMIM). .
The Diabetes Insipidus Foundation. .
: The body naturally produces an antidiuretic or urine-limiting hormone called arginine vasopressin (AVP). AVP signals the kidneys to return water to the blood and helps to control the concentration of the urine. In people with nephrogenic diabetes insipidus (NDI), the kidneys cannot properly respond to this hormonal signal and produce abnormally high amounts of dilute urine. NDI may be either acquired or inherited.
Acquired NDI
: Acquired NDI is usually caused by certain drugs, such as lithium and certain antibiotic, antifungal, chemotherapy, and antiviral drugs. It can also be caused by severe dehydration, urinary blockage, or an electrolyte imbalance, such as an elevated blood sodium level (hypernatremia) or an elevated blood chlorine level (hyperchloremia). When NDI is induced by a drug, the drug damages the kidneys in such a way that they are unable to respond to AVP. Disturbance of the aquaporin-2 shuttle, a channel that makes the kidneys collect more water, is the cause of acquired NDI.
Inherited NDI
: Inherited NDI is caused by defects in either the
or the
gene. About 90% of patients with inherited NDI are males with X-linked recessive NDI who have mutations in the AVP receptor 2 (
) gene, which provides instructions for making the AVP V2 receptor in the kidney. Other modes of inheritance are autosomal recessive (9%) or autosomal dominant (1%). These forms of the disease are caused by mutations in the aquaporin-2 (
) gene, which provides instructions for making the vasopressin-sensitive water channel in the kidney. Males are more likely than females to be affected by inherited X-linked NDI, whereas males and females are equally likely to display symptoms of NDI that is inherited as an autosomal recessive or an autosomal dominant trait.
Risk factors
Acquired NDI
: Acquired nephrogenic diabetes insipidus (NDI) is usually caused by certain drugs, such as lithium, demeclocycline, and aminoglycosides. It can also be caused by severe dehydration or an electrolyte imbalance, such as an elevated blood sodium level (hypernatremia) or elevated blood chlorine level (hyperchloremia).
Inherited NDI
: Inherited NDI is caused by mutations or defects in the
genes. NDI can be inherited in several ways. Most people inherit NDI as an X-linked recessive trait. About 90% of people with inherited NDI are males who have inherited the disease as an X-linked recessive trait. About 10% of people with inherited NDI inherit the disease as an autosomal recessive or autosomal dominant trait. X-linked recessive NDI is caused by mutations in the AVP receptor 2 (
) gene, which provides instructions for making the AVP V2 receptor in the kidney. Autosomal dominant and autosomal recessive forms of NDI are caused by mutations in the aquaporin-2 (
), which provides instructions for making the AVP-sensitive water channel in the kidney.
X-linked inheritance
X-linked NDI is estimated to affect 1 in 200,000 males. Females have two X chromosomes while males have one X and one Y chromosome. Because males inherit an X chromosome from the mother and a Y chromosome from the father, males can only inherit X-linked diseases from the mother. In females who have one copy of the defective gene that causes NDI, the normal copy of the gene on the other X chromosome can compensate. Because males have only one X chromosome, they are more likely than females to show symptoms of X-linked NDI.
Females with one copy of the defective gene that causes NDI do not generally show symptoms but are called carriers because they may pass the defective gene to their children. If a female carrier has daughters with an unaffected male, their daughters have a 50% chance of being carriers for the disease. These daughters may show some symptoms, but are unlikely to have a serious form of the disease. If a female carrier has sons with an unaffected man, the sons have a 50% chance of getting the disease.
Autosomal recessive inheritance
: To inherit NDI as an autosomal recessive trait, one must inherit two mutated alleles of the causative gene (one from each parent). A person who has only one mutated allele does not generally experience symptoms and is called a carrier. If one parent is a carrier, there is a 50% chance with each birth that the child will also be a carrier and a 0% chance that the child will inherit the disease. If both parents are carriers, there is a 25% chance with each birth that the child will inherit the disease and a 50% chance that each child will be a carrier.
Autosomal dominant inheritance
To inherit NDI as an autosomal dominant trait, one must inherit only one copy of the mutated gene for the disease to manifest. If one parent has the condition, therefore, there is a 50% chance that each of his/her children will have the disorder.
Types of the disease
Acquired NDI
: Acquired nephrogenic diabetes insipidus (NDI) occurs more frequently than inherited NDI but is still a rare disorder. It is usually less severe than inherited NDI and can occur at any time during the life cycle. Acquired NDI is usually caused by certain drugs, such as lithium and certain antibiotic, antifungal, chemotherapy, and antiviral drugs. It can also be caused by severe dehydration, urinary blockage, or an electrolyte imbalance, such as an elevated blood sodium level (hypernatremia) or an elevated blood chlorine level (hyperchloremia). When NDI is induced by a drug, the kidneys become damaged in such a way that they are unable to respond to anti-diuretic hormone. Disturbance of the aquaporin-2 shuttle, a channel that makes the kidneys collect more water, is the cause of acquired NDI.
Acquired NDI can also occur as a consequence of more fundamental disorders, such as kidney disease, abnormally low levels of potassium, abnormally high levels of calcium, or sickle cell disease. Acquired NDI may also be caused by one or more of the ureters becoming blocked during pregnancy or as a result of protein starvation. Acquired NDI can be either permanent or temporary, depending on the length of exposure to the drug or condition that caused the symptoms to occur.
Inherited NDI
: Inherited NDI is caused by defects in either the AVP receptor 2 gene (
or the
aquaporin-2 gene (
). Approximately 90% of patients with inherited NDI are males with X-linked recessive NDI who have mutations in the
gene, which provides instructions for making the AVP V2 receptor in the kidney. Other modes of inheritance are autosomal recessive (9%) or autosomal dominant (1%), in which the defective gene is
, which provides instructions for making the vasopressin-sensitive water channel in the kidney. Males are more likely than females to be affected by X-linked NDI, whereas males and females are equally likely to display symptoms of the autosomal forms of inherited NDI.
: Some doctors have described a third type of NDI called partial NDI. Individuals with partial NDI are diagnosed later in childhood. These individuals usually do not have delayed growth or development, and they are able to concentrate the urine in response to dehydration but not as well as unaffected individuals.
Copyright © 2011 Natural Standard (
The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.
Search Site
Entire Site
Reference Room
Healthy Recipes
News & Features
About Our Store
Reference Room
Cone's Links
My Email Subscription
Contact Us
Privacy Policy
Terms of Use
All contents © Copyright 1999-2019 Genius Central and Cone's Health Foods. All rights reserved. This internet site is hosted by Genius Central, a Web site service provider to natural health stores nationwide. Genius Central and Cone's Health Foods have no means of independently evaluating the safety or functionality of the products offered by their suppliers and affiliates and thus can neither endorse nor recommend products. Information presented is of a general nature for educational and informational purposes only. Statements about products and health conditions have not been evaluated by the US Food and Drug Administration. Products and information presented herein are not intended to diagnose, treat, cure, or prevent disease. If you have any concerns about your own health, you should always consult with a physician or other healthcare professional. Your use of this site indicates your agreement to be bound by our
Terms and Conditions
Cone's Health Foods
8200 Stockdale Hwy
Suite B-3
Bakersfield, CA 93311
(661) 832-5669
Monthly Newsletter
Enter your e-mail address into the field below to subscribe to our monthly newsletter.
Social Networking
Copyright © Cone's Health Foods. All rights reserved.


text:
Outils d'accessibilité
Sélecteur de langues
Chemin de navigation
Left navigation
Additional tools
Autres langues disponibles: aucune
Brussels, 20 December 2011
Commissioner Michel Barnier welcomes agreement by Council and Parliament establishing SEPA migration end-dates
"Today's agreement by the European Parliament and the Council represents a significant step towards a truly integrated market for electronic retail payments in euro.
By February 2014 SEPA credit transfers and direct debits across the euro area will be as easy as domestic payments within one country are now. The reasonable transition periods applied will allow customers and banks to get used to the adjustments in domestic payment transactions, provide legal certainty, avoid the cost of operating dual payments systems and bring forward the substantial future benefits of SEPA.
For a successful SEPA migration, banks, merchants, national public authorities and national central banks should commit to stressing and marketing actively the importance of SEPA products and services by facilitating IBAN migration and by considering the launch of appropriate publicity campaigns.
The advantages of the changeover are manifold and will benefit all actors involved. European citizens including workers, students, holiday owners, tourists and retirees living abroad will be able to rely on one bank account to make credit transfers and direct debits throughout the 32 SEPA countries.
This Regulation also strengthens the position of consumers when making payments. Users of SEPA direct debits now explicitly have the right to limit direct debit collections to a specific amount or to a certain periodicity and to block direct debit transactions in relation to specified people. Moreover, a verification of each direct debit transaction by the payment services provider is foreseen in cases where no refund right is provided for in a mandate.
SEPA brings also a cost-cutting potential mainly for companies operating throughout Europe as well as authorities as there will be a wider choice of payment service provider, faster and more efficient processes as well as greater transparency. Similarly businesses will enjoy common standards; faster settlement and simplified processing that will improve cash flow, reduce costs and facilitate access to new markets.
By agreeing with the Commission proposal to fix a deadline for the migration to pan-European payment instruments just over a year after it was proposed, the European Parliament and the Council have risen to the ambitious challenge to increase the efficiency of our payment systems so that high-quality and competitively priced electronic payment products exist throughout the whole of the EU."
See MEMO/11/936 for more details on agreement reached.
Side Bar


text:
Go Beyond the Obvious
Trusted Leader in Inventory Management & Industrial Distribution
Würth excels as the premier distributor of supply chain solutions, delivering C-Parts, specialty fasteners, production consumables, safety equipment, and more.
But that's only half the story. Because just as important as parts are, maximizing reliability for your organization is paramount. It's why our people remain urgently focused on providing the right product at the right time and at the right price — every time.
When Status Quo Isn't an Option
Is your supplier doing enough? We work closely with our customers to drive bottom line results and support your business goals. You'll benefit not only from our broad experience in inventory and supply chain management, but from our comprehensive approach and capability to customize an intelligent logistical solution, tailored to your business and unique challenges, and our ability to react to changing demands. Learn more.
Better Products and Services
Effective inventory management is only possible if you have the right products, combined with the right logistical supply concepts. Würth offers a range of more than 1,000,000 items for industrial production, maintenance and repair, personal protection, and more. And, we take the initiative to ensure the integrity of every part we supply so that every order and every product is delivered with the quality you expect. Learn More.
Strategic, Profitable Partnerships in Your Industry
We're proud to work with customers who share a passion for developing leading products and innovative solutions.
Würth provides solutions for a wide range of industries, ranging from the industrial manufacturing industry, the agriculture industry to construction, heavy equipment, or oil and gas industry; our goal is to help you reduce costs, drive growth, and provide bottom-line results. Learn more.


text:
Log in
What if the entire community read the same book at the same time? This year, we feature TWO different titles written by TWO different authors. The theme, in a word, is FOOD.
Reading Together 2014 feature author.
by Tracie McMillan
by Novella Carpenter
Several weeks have passed since Novella Carpenter was in town as the final event of Reading Together 2014. During that time, we have been busy collecting statistics, photos, and feedback about this year's program.
For instance, did you know:
Of course, we've always believed that last point to be true, but these results affirm it. And it won't be long before we start the process all over again to select a title (or titles?) for Reading Together 2015. Have a suggestion? Use the Contact link to the right and let us know!
Until next year,
We've just received this photo and a note, transcribed below, from Novella about her visit to Kalamazoo...
Karen,Thanks again for the good times in Kalamazoo!
What I really loved about K:1. It felt like home; everyone there was so welcoming and down to earth. It was like meeting old friends.
2. Conversation. You guys know how to ask questions, be honest, and you all are so curious! It's an amazing & rare thing these days.
3. Places that matter. I was only in 'Zoo for one night but got to experience a lot—the Food Co-op, Tabitha Garden and the Art Museum/KIA, and the food trucks on the square, and of course, the Library and K College campus—these are all awesome, beautiful, functional, fun, accessible places where the town can grow and thrive.
Anyway, I had a blast—thanks for the opportunity and I'm telling my friends about Kalamazoo!
Love, Novella (and Franny)
It wasn't until I read Farm City: The Education of an Urban Farmer for the second time that I really grasped the enormity of Novella Carpenter's drive to prove herself as a farmer, which, at times she says, felt like "the mission of an imbecile."
It's hard to imagine a more unconventional – or difficult - way of carving out an existence for oneself: a squatter on land in an urban neighborhood that initially doesn't feel safe. But it turns out the garbage strewn lot next to her apartment and Oakland's "down and out qualities" are just right for Carpenter and her boyfriend, Bill, to put down roots of all kinds.
The rollicking good ride we get to go on with Carpenter includes massive slug extermination in which the slimy, primitive creatures are ripped in two and then squished between boards (this is organic gardening, after all), prolifically pooping poultry, bees, pigs, rabbits, dumpster diving and scrounged stuff from street corners. Carpenter possesses a love of making something useful again, which she describes as "resurrecting the abandoned." The folks we meet come to life on the page: Lana ("anal spelled backwards"), monks, men that live in wheelless parked cars. The farm changes the neighborhood and the author. Against odds and convention, Carpenter not only exists, but she thrives.
I can't wait to meet her this week!
~ Donna McClurkan, Reading Together Steering Committee


text:
From Mars to Earth: The Tech of Total Recall
Total Recall (1990), directed by Paul Verhoeven of Robocop, Basic Instinct, and Showgirls fame/infamy and starring the former governor of California (you know the one), is considered by many to be a sci-fi classic.
Looking at it now, one might deduce that the film is a campy, over-the-top bit of crazy captured on celluloid, especially when compared with the ultra-realistic science fiction films of Verhoeven's contemporary, Ridley Scott. His work on Blade Runner alone set the standard for how "into-the-future" sci-fi films would look for a long, long time.
(Um, Blade Runner is also a much, much better movie. At least I think so.)
This time around, expect Total Recall to get a serious reboot from director Len "Underworld" Wiseman. The new film keeps things earthbound in the year 2084 rather than taking the main character, Doug Quaid (played by Colin Farrell), to Mars. He now lives on an earth split into two giant nation-states, New Asia and the United Federation of Britain.
Both Total Recall and Blade Runner are based on stories by author Philip K. Dick. Very loosely based. Total Recall comes from 1969's "We Can Remember It for You Wholesale," which is also about Mars, memory implanting, and recording. Blade Runner is taken from 1967's tale of android hunting, "Do Androids Dream of Electric Sheep?"
The remake swaps Arnold Schwarzenegger one-liners and over-the-top mutant animatronic special effects—which actually won an Academy Award back in 1990—for a realistic-looking future that resembles a blend of Blade Runner, The 5th Element, and Minority Report. (The latter is also based on a PKD story.)
Here's a quick look at the coolest technology from the original and the remake of Total Recall. The original has a few very interesting pieces of tech that are practically commonplace today—and a lot more that aren't. Here's hoping the remake's tech starts becoming a reality soon, too.
1 Rekall
2 Rekall Kart/Holographic Interface
3 The Mask
4 X-Rayed Skeletons
5 The Artifact
6 Nasal-based GPS
7 Insta-Color Nails
8 Johnny Cab
9 Robot Cops
10 Tractor-beam Bolo
11 Hover cars
12 China Fall
13 Implanted Mobile Video Phone


text:
Can You Guess the Celebrity Cleavage?
Can you guess the 25-year-old media personality who owns this lovely set of sweater puppies? This babe wears many hats and can be seen as an actress, a model, a TV personality and a singer-songwriter, but her main passion is hip-hop and R&B.
You might have seen this lady rapper on MTV's 'Rob Dyrdek's Fantasy Factory' and 'Ridiculousness.' She came to prominence on the first show in 2009. She's based out of Los Angeles, which is perfect for all of the professional plates she keeps spinning thanks to her unique talents.
Do you know who this foxy rapper is?


text:
HARTSVILLE, S.C. – Jessica Cohen (Ladsen, S.C.) posted a double-double of 23 points and 10 rebounds in the Coker women's basketball team's 70-64 loss to the College of Coastal Georgia.
The Cobras came out strong, putting up 35 points in the opening half, taking a five-point lead into the break. Then in the second half, Coastal Georgia turned on the pressure tying the game at 39 with 17 minutes left. The Cobras quickly answered and built as much as a 10 point lead, 59-49, with seven minutes remaining.
The Mariners were not to be out done and thanks to an 11-2 run over the next four minutes they evened things at 61 all. Coker stayed within a basket of the Mariners and even trailed by just one, 65-64 with a minute left in the game. However, a layup by Olivia Melvin with 34 seconds left and the ensuing free throw put Coastal Georgia on top for good.
In addition to Cohen's double-double, Amber Lau (Mt. Wolfe, Pa.) added 13 points and Jasmine Evans (Birmingham, Ala.) had eight points.
Coastal Georgia's Courtney Saunds led all scorers with 24 points and Maria Marshall had a double-double with 14 points and 11 rebounds.
The Cobras will be back in action on Tuesday, Jan. 3 when they begin Conference Carolinas play on the road at Mount Olive College. Tip-off is scheduled for 5:30 p.m.


text:
Register of Wills[Record group 9]
Agency home page.
Agency Function
- The Register of Wills, elected to a four-year term, has the responsibility to: probate wills ("probate" is official proof of an instrument offered as the last will and testament of a person deceased); grant letters of testamentary appointing will executors; issue letters of administration appointing estate administrators when persons die without a will and approve and file the accounts of executors and administrators. The Register's office records all wills, accounts, inventories and appraisals of estates.
In a separate capacity, the Register of Wills also serves as clerk of the Orphans' Court Division of the Common Pleas Court. As such, the Register supervises the Marriage License Bureau and performs administrative duties similar to those of the Prothonotary in the Common Pleas and Municipal Courts. As clerk of Orphans' Court, the Register of Wills issues marriage licenses and keeps a record of Orphans' Court proceedings, as well as estate accounts filed and settled. It carries out these activities under the supervision of the court judges.
- Agency History
- The Provincial Registers were the Registers-General of Pennsylvania for the Probate of Wills and Granting Letters of Administration, established by the 22nd section of the Laws agreed upon in England (Colonial Records, vol. 1) The Act of 14 March 1777 abolished the office of Register-General and named the Registers of Wills in each county to succeed the Deputies of the Register-General. Under Article V, Section 22 of the Constitution of Pennsylvania in 1874, the Register of Wills became ex-officio the clerk of the Orphans Court.
- Archival Records
- No holdings
- Current Records
- Unavailable
Click on a folder or file to return to that level...
PhILS Home
City Agencies
Current Agency Information Sheet. (Text-only version of this page)
Send your comments to email@example.com
Last updated on November 8, 2000