ESABASE2/Debris is ESA's tool to assess the probability of space debris and micro-meteoroid (MMOD) impacts and failures on spacecraft. It includes a high variety of capabilities, such as 3D modelling, consideration of different MMOD environment models, and various particle-wall interaction models. A variety of MMOD environment models exist. To reflect the current understanding of micro-particle populations, it is important to use the most recent models in the risk assessments. Recently, ESABASE2/Debris has been updated, implementing NASA's most up-to-date space debris and micrometeoroid models ORDEM 3.0 and MEM release 2 (MEMr2). The validation was performed by means of a result comparison of impact flux with the stand-alone model as well as impact flux and damage assessment results with NASA's Bumper application. Moreover, the capabilities of ESABASE2/Debris have been extended to provide automated variation of calculation parameters and serial execution of multiple analyses.


The embodiment of the invention discloses a method for adjusting main menu layout and a terminal device. The method disclosed by the invention comprises the following steps: acquiring at least the function startup information at least containing a function ID (identity); opening a configuration file, inquiring the corresponding frequency in the configuration file according to the function ID, and adding 1 for the frequency, wherein the function information comprises the function ID, the frequency and a function icon storage address; then judging whether the position of the function information corresponding to the function ID needs to be moved forwards, and if yes, moving the position of the function information forwards so as to enable the frequency corresponding to the predecessor of the function information to be larger than that corresponding to the function information; and arranging function icons in sequence in the screen layer according to the sequence of the function ID in the configuration file. In the method disclosed by the invention, the individuality and using habit of each user are taken into consideration, main menu layout is ensured to be changeable, the design is more individualized and diversified, and the user experience is greatly improved.


The Optical Transconductance Varistor (OTV) represents a new class of power electronic device that is photonically controlled. It eliminates the traditional semiconductor control junction by exploiting the bulk photonic properties of wide bandgap (WBG) materials. Without drift region limitations, carrier excitation occurs on the order of picoseconds and in the bulk of the crystal; decay of the carriers is dependent on doping. Conductivity is therefore proportional to optical intensity so the device exhibits a transconductance-like property. The device is bi-directional and inherent optical isolation provides scalability in voltage and current capability. Recent testing demonstrated operation at 20 kV and 2.5 A at over 125 kHz switching frequency; our target is a 20 kV, 10 A device. The OTV has broad application in medical equipment, radar, and HVDC and other equipment for the Smart Grid, reducing energy losses and the size and cost of equipment. Device background, present status and future development are set forth.


Cotton stalks pulped by soda (S) and soda-anthraquinone (S-AQ) liquor under various surrounding gases, e.g. nitrogen and oxygen. All soda-anthraquinone pulps produced under air or nitrogen atmosphere (0.5 MPa) were characterized by increasing of pulp yield and decreasing of lignin content. The most advantageous effect of a limited air present in pulping liquor was the stabilization of the carbohydrate fraction against peeling off reaction without retarding the catalyzed effect of AQ on delignification and carbohydrate stabilisation, too. However, treatment of cotton stalks under oxygen pressure (0.5 MPa) instead of air, has tremendously increased the total yield from 29.6 to 50.7% and lignin from 5.0 to 23.6%, respectively. Increasing the oxygen pressure to 1.0 MPa lowers the carbohydrate yield and degree of polymerization (D.P.) of the products. In addition, this treatment is indicated by the higher alkali consumption values than those by using air or nitrogen äs surrounding gases. The effect of bark and extractives removal were also studied under the above pulping conditions. The same pulping trends were also observed.


In the course of the last twenty years I have observed at the Cancer Division of the Montefiore Hospital, at the New York City Cancer Institute and in my private practice more than 500 cases of lymphoma malignum (Hodgkin's disease) and lymphosarcoma. The patients were studied clinically for months and years and in the majority of cases the study was accompanied by a complete pathologic analysis of the surgical and the postmortem material. Through those years of parallel study of lymphoma malignum and lymphosarcoma on the one hand and of all clinical types of carcinoma and sarcoma on the other, I have gained the conviction that lymphoma malignum (Hodgkin's disease) and lymphosarcoma are nearly identical in their clinical manifestations, that they both represent a special type of malignancy and that the peculiarities in the structure and clinical manifestations of lymphoma malignum (Hodgkin's disease) as compared with other types of malignancy


Resveratrol, a polyphenol extracted from many plant species, has emerged as a promising pro-apoptotic agent in various cancer cells. However, the role of resveratrol in cell proliferation and apoptosis of fibroblast-like synoviocytes in rheumatoid arthritis (RA-FLS) is not fully understood. The study was aimed at elucidating the role of resveratrol in cell proliferation and apoptosis of RA-FLS and the underlying molecular mechanism.Cultured RA-FLSs were subjected to tumour necrosis factor  (TNF-). The cell proliferation was measured by Cell Counting Kit-8 assay. Cell apoptosis and cell cycle of RA-FLSs were determined by flow cytometry. The levels of apoptosis or autophagy or cell cycle-related protein were detected by immunoblot analysis.In our study, we confirmed that resveratrol reversed TNF- mediated cell proliferation in RA-FLS. Meanwhile, resveratrol blocked cells at the G2/M stage and reduced the ratio of S phase cells through upregulation of p53 and consequently led to apoptotic cell death. Quite interestingly, we found that resveratrol reversed TNF--induced autophagy. Inhibition of autophagy by resveratrol or autophagy inhibitor or Beclin-1 siRNA suppressed TNF- mediated cell survival and promoted cell apoptosis. However, the autophagy inducer rapamycin (RAPA) reversed the effect of resveratrol on autophagy and cell proliferation. Mechanistic studies revealed that resveratrol inhibited the activation of the phosphoinositide 3-kinases/serine-threonine kinase (PI3K/AKT) pathway. Inhibition of PI3K/AKT pathway by inhibitor LY294002 or resveratrol increased the expression of p53 and decreased the expression of cycle protein (cyclin B1), which further led to block cells in the G2/M arrest.Our preliminary study indicated that resveratrol may suppress RA-FLS cell survival and promote apoptosis at least partly through regulation of autophagy and the AKT-p53 axis.


It is well known that it is the surface of almost every engineering product or component that will define its lifetime and performance. The surface is where corrosion and wear occur, where friction is generated and where cracks and defects can have their most profound effect on the component's strength and fatigue life. Also, since the surface is the part we see, it brings aesthetic attributes which should be maintained over the service life. The critical nature of the surface doesn't, however, end with the lifetime-defining properties. The surface is also key to the achievement of vital physical functionalities – such as biocompatibility, thermal conductivity and optical properties such as the reflectivity. Electronic and magnetic characteristics are also often controlled by the surface. It would be no exaggeration to claim that none of the great technological achievements in new products over recent years could have occurred without major developments in processes and techniques to impart previously unachievable surface properties. This is true whether we speak about the screen of an iPad (with wearand crack-resisting touch screen capabilities), modern high economy diesel engines with injectors which have a thin low friction wear-resisting surface, or the surface of a hard disc drive which is designed to protect against damage and data-loss during a read-write head crash. These are just a few of the products which we now take for granted but which could not have been created even a few decades ago, were it not for the development of exciting new coating and treatment processes. Many of these processes utilise a plasma or gas discharge to assist in the deposition process (1). Usually this is created in a vacuum, but it may also be created at atmospheric pressure and even in a liquid (2). This talk will speak about the development of these plasma assisted processes, providing a brief chronology of their development (demonstrating 4 "waves" of innovation (1)) and explain how researchers in the Research Centre in Surface Engineering have had a significant role in these developments, over a period of almost 30 years. Part of this research success has arisen through the group's ability to span technologies; i.e not only the coating and treatment processes but also the application-related technologies (such as the materials processing and manufacturing fields in which the coatings are used (for example on tooling) and the diverse sectors in which the coated products are used (such as automotive, aerospace and energy). It is probably not widely realised that the surface coating industry is one of the most important manufacturing sectors in the UK. This has been demonstrated in studies over the past 20 years (3, 4, 5). The most recent findings are that the UK surface coatings industry has a turnover of about £11 billion, the products critically affected by coatings have a value of over £140 billion, and these are used in industrial sectors which together have a turnover value in excess of £383 billion to the UK economy each year (6). The Sheffield surface engineering research has been particularly driven towards applications-related developments, often with funding directly from industry and sometimes through joint support from industry and government (such as the EPSRC and/or TSB). The talk will mention some of these success stories, such as the replacement of a steel-bronze bearing on the Airbus A380 landing gear with one made from titanium (7). The design thinking behind the development of this innovation will be mentioned, which includes the production of a load-supporting plasma diffusion treatment in combination with an advanced coating with enhanced mechanical properties having an optimized ratio between the hardness and the elastic modulus (8, 9, 10, 11, 12).


As the largest country in the Middle East, Saudi Arabia and its health care system are well positioned to embark on an online learning intervention so that health care providers in all areas of the country have the resources for updating their professional knowledge and skills. After a brief introduction, online continuing medical education is explored. Benefits and barriers of using online continuing education are noted and logistical concerns are highlighted. The article ends with lessons learned and implications for the future.


Polarization measurements in the IR region are useful for the detection of man-made objects in natural environment. Surface laid landmines are examples of man-made objects that are difficult to detect, especially when a certain time have elapsed. As time goes by, both IR signature and degree of polarization are reduced, due to the dust coverage and the grass that has grown around the mines. Polarization measurements are useful when detecting Trip Wires. This article reports the results of IR polarization measurements compared to the measurements without a polarizing element. To simulate the dust and grasses that can cover the mines, a series of controlled covers are constructed. Measurements on this series are performed, and the results are shown in a diagram of relative Degree of Linear Polarization, (DoLP) as a function of coverage. The same is done for the case without a polarizer but here the relative radiance is shown. By comparing the two diagrams a measure is achieved of how effective the polarization measurements are with respect to the case without a polarizer. A simple parameter model of the coverage has been made and has been compared with the measurements. Measurements indicate that detection of trip wire is improved when using polarization measurements.


Abstract Students of Chinese intellectual history are familiar with moral cosmology developed in the Han era, a theory that alleges that ru use omens to admonish the emperor, and thereby to constrain and compete with his absolute political power. This thesis, in theory, is convincing; in actuality it is not. This article questions the autonomous power of omen discourse. Focusing on the socio-political conditions in which this discourse functioned, it demonstrates that, in real politics, the enactment of omen interpretation had nothing to do with restraining the power of the throne, but evolved with bloody factional struggles. Replacing the secret knowledge of diviners and astrologers with the common cultural heritage—the classics—and transforming the mysterious otherworldly spirits into a moral agent, ru successfully defeated the technical specialists and became the primary operators of the omen interpretation enterprise. The theoretical innovation that contributed to ru's success, however, undermined their chance of building a social closure both to close off competition and to secure their interpretative authority. As numerous historical cases show, neither the ru classics nor the moral competence of the speaker add to the social efficacy of omen explanation: without monopolised knowledge, standardised hermeneutic rules, or institutionalised positions, omen discourse, rather than contesting political power, became its servant.


Shifting toward service-oriented administration is necessitated by the development of China's public administration.In view of the complexity of administrative ecology in China,this shift must be done through reforming various administrative elements closely linked to the national conditions.In this context,the service-oriented government must implement new administrative act to complete a variety of administrative tasks in the new administrative mode.Compared with the traditional administrative act,these new administrative behaviors show the following overall features:systematic changes in behavior function,diversification behavior agents,flexibility in behavior reference,diversification of behavior modes,hierarchical validity of behavior,clarity in behavior purpose,and atypical characteristics in administrative remedies.On the basis of these behavioral features,we can continue systematic studies on the new administrative act,and rebuild theories about administrative acts,which have become topics of contemporary values in administrative legislation.


Idea to develop this project: Fresure Beverage Management System (FBMS) we
got because of our interest to know better and closer how the companies that involves in
small and medium industry manage their products and all components of the company
such as staffs, stocks, and sales. It is seldom to hear that a foods and beverages based
manufacturing company using a modern computerized system to manage the
information or data about the company such as products and staffs. So, by developing
this system, it is indirectly can attract the companies to use this system to help the
company to increase business efficiency and sales performances. By using this system, it
can save all the important and useful company data into one database system. We hope
that the company that involves in this type of industry like beverage Production
Company can compete with the other competitors whether in small-medium Industry
Company or big industry company and can market their products to the global. We hope
also that more people will be interested to involve in business field.


The purpose of the present invention is to provide a vehicle front glass that has a laminated glass structure in which a laminated glass interlayer is sandwiched between at least one pair of glass plates, the laminated glass interlayer comprising a laminate body that comprises two or more layered resin layers. The vehicle front glass has few air bubbles that remain between the glass plates and the laminated glass interlayer, has an excellent exterior appearance, and is unlikely to produce ghost images when exterior light is viewed through the vehicle front glass. The present invention is a vehicle front glass that has a laminated glass structure in which a laminated glass interlayer is sandwiched between at least one pair of glass plates, the laminated glass interlayer comprising a laminate body that comprises two or more layered resin layers, at least one surface of the laminated glass interlayer having a plurality of concave portions and a plurality of convex portions, bottom portions of the concave portions having continuous groove shapes, and adjacent concave portions being parallel and arranged regularly in lines. On the laminated glass interlayer surface that has the plurality of concave portions and the plurality of convex portions, the groove depths (Rzg) of the concave portions as measured in accordance with JIS B-0601 (1994) are 10-40[mu]m, and the directions of the continuous groove shapes of the bottom portions of the concave portions of the laminated glass interlayer surface are positioned so as to be at an angle of 30 degrees or less with regard to the vertical direction of the vehicle front glass.


The interest in microturbines and new distributed generation technologies is growing in the entire world because of the many potentially beneficial characteristics they can offer and the developments achieved so far. This paper investigates the performance and degradation effects of microturbines for electric power generation. Diagnostics investigation is also carried out to obtain optimal instrumentation sets for degradation faults. Here the capacity of the gas turbines analyzed is 29kW simple and regenerative cycles. The engine performance is also analyzed operating at constant and variable speed. To simulate the gas turbine performance and carry out the diagnostic analysis the software Pythia and Turbomatch, developed by Cranfield University, were used. In this paper the engines above are simulated at degraded conditions. The effects of the degradation in the compressor, turbine and recuperator on the performance of the engines were investigated. Despite of the improvement on performance achieved with regenerative cycle and variable speed operation the results show that the performance of variable speed microturbines is more sensitive to components degradation than constant speed engines. Also recuperator degradation has greater effect on variable speed than constant speed engines. Due the effects of degradation on each engine different diagnostic approaches are observed.Copyright © 2006 by ASME


A theoretical calculation is presented for the main uv transitions of the polyacenes, azulene, phenanthrene, the isomers of naphthacene and the peri‐condensed systems pyrene and coronene. A configuration interaction treatment, based on antisymmetrized products of free‐electron molecular orbitals, is carried out, using the methods developed for this purpose in the previous paper. Transition energies, intensities and polarizations compare well with experiment. Particular emphasis is placed upon illuminating the various factors influencing the spectra in the series of molecules considered.


This paper discusses the mechanism and application of denitrification inhibition to the activity of sulfate-reducing bacteria in wastewater treatment of domestic and overseas oilfields.All factors affecting this process and shortcomings in the process were reviewed as well.It is suggested that the study on protein structure and environmental gene is important for the mechanism research,particularly for studying the effect of addition of inhibiting agents,such as nitrate and denitrifying bacteria,on the gene and protein structure of sulfate-reducing bacteria as well as the metabolism process.It is critical to investigate this process from the view of microbial molecular ecology.The case application has also been studied for Daqing Oilfield.


Continuous condition monitoring and fault diagnosis of motor bearings are vital to guarantee motor safety operation and reduce breakdown losses. With numerous Internet of things (IoT) sensors being installed on motors for condition monitoring, data transmission and storage problems have become new challenges. This study designed a signal enhancement and compression (SEC) method and implemented on an IoT platform for motor bearing fault diagnosis. First, vibration signal is acquired from an accelerometer installed on the motor. The bearing signal is demodulated using an online demodulation algorithm. Second, an envelope signal is downsampled and enhanced using a stochastic resonance-based nonlinear filter. The enhanced signal is compressed using an Opus encoder and transmitted to a receiver. Lastly, the received signal is decompressed using the Opus decoder, and the bearing fault type can be recognized. The effectiveness and efficiency of the proposed SEC method are verified on an IoT platform compared with a conventional method. The proposed method improves 3.83 dB of the average signal-to-noise ratio (SNR), and reduces 94.7% of the total time and 94.6% of the dissipative power. The advantages of the proposed SEC method include high output SNR, low power consumption, and compatibility with edge computing. These advantages show potential applications in remote motor fault diagnosis using battery power supply.


A wideband dual-polarized metasurface antenna is proposed using characteristic mode analysis (CMA) for Ka-band applications. To achieve the dual-polarization, a primary patch is introduced with orthogonal microstrip-feeds in the same layer with a low profile, low cost and low back lobe level. Furthermore, the single-feed and differential-feed are adopted for vertical polarization (VP) and horizontal polarization (HP), respectively, to enhance the port isolation. A $2\times 2$ metasurface is presented for wideband operation and the CMA is used to determine the modal behaviors of the entire structure. Simulation results show that the return losses of both ports are better than 10 dB and the isolation is higher than 20 dB over 30.1-39.6 GHz. The simulated gain ranges 4.7-6.9 dBi and 7-7.5 dBi for VP and HP, respectively.


In electrolytic processing, the flow field of the electrolyte, the applied voltage, and the magnetic effect of the current itself have a significant effect on the stability, efficiency, and surface quality of the process. In this paper, the effects of different inlet pressures on the flow rate and different treatment voltages on the current density and magnetic induction strength are investigated by coupling several fields, such as flow, electric and magnetic fields, using COMSOL software. The simulation results show that the flow rate increases with the increase of inlet pressure, and the flow rate increases by 1 m/s for every 0.1 MPa. The current density increases with the increase of processing voltage, but its uniformity decreases, and the magnetic effect of the current itself also influences the magnitude of the current density


One day, you will discover a new adventure and knowledge by spending more money. But when? Do you think that you need to obtain those all requirements when having much money? Why don't you try to get something simple at first? That's something that will lead you to know more about the world, adventure, some places, history, entertainment, and more? It is your own time to continue reading habit. One of the books you can enjoy now is creative nursing administration participative management into the 21st century here.


China's civil service system has been implemented for many years, but the hiring and assignment process has been controversial. The mail reason is the lack of scientific evaluation and reasonable explanation. In view of this situation, based on the fundamental principle of fairness and the overall optimal, a fuzzy comprehensive evaluation model is proposed by construction of single-factor evaluation matrix and using Delphi technique to obtain weight of each factor. The merit candidate selection method in public servant recruitment process is achieved by the solutions which are further derived from the model. The model is very promising to be implemented in real recruitment process. It can also be used to solve other similar problems.


Well-organised harmonic modelocking with up to 12 pulses in a 1.5 /spl mu/m polarisation-maintaining erbium soliton fibre laser is achieved. With eight pulses in the cavity, repetition rate timing jitter is suppressed by 7.3 dB through optical pumping above the absorber bandgap. This stabilised laser operates at 463 MHz with nearly transform-limited, 660 fs, 1 pJ pulses.


Aims-Toassesstheroutine useofa polymerase chainreaction (PCR)assay for the directdetection of Mycobacterium tuberculosis inexpectorated sputumspecimens. Methods-Apairofprimers(20-mer) weredesigned toamplify the38kilodaltonprotein ofM tuberculosis. Thespecificity oftheassaywasevaluated in31M tuberculosis strains, 15atypical mycobacterium species, andseveral commensalbacteria oftheupperrespiratory tract.The assaywas subsequently applied to519sputumspecimens from85 inpatients ofa chesthospital inHong Kong. Results-Anamplified productof239 basepairs wasfoundinallM tuberculosis strains, standard strains ofM bovis, and M africanum butnotintheotherbacterialstrains tested. Forthe51patients with pulmonaryradiographic lesions, the diagnosis ofpulmonary tuberculosis was subsequently confirmed bybothculture andPCR in41ofthem.Fivepatients whoweretreated beforeadmission were positive by PCR alone.Allbut one patient inthecontrol group(patients with acute exacerbation of chronic obstructive airwaydiseases) or those withatypical mycobacterial diseases werePCR negative. ThePCR remained positive after fourweeksofanti-tuberculosistreatmentin 29 patients, 16 of whomhadbecomeculture negative. Conclusion-This PCR assayisa useful technique forthediagnosis ofuntreated andrecently treated casesofpulmonary tuberculosis.


Abstract: Thymectomy has been regularly used in the management of nonthymomatous autoimmune myasthenia gravis (MG), but its benefits have not been established in a randomized, controlled trial. The widespread use of thymectomy in MG patients without thymoma is largely based on retrospective, nonrandomized case series that have produced a consensus that the procedure is sometimes beneficial. Still, the benefits and utilization of thymectomy are actively debated among MG experts. In this paper, we describe the development of a multicenter, international trial to determine whether extended transsternal thymectomy reduces corticosteroid requirements for patients with generalized AChR antibody‐positive nonthymomatous MG.


The changing role and organisation of the armed forces requires new methods for development, evaluation and operation of military equipment, and for the training of personnel. Simulation is an acceptable solution to reduce costs and protect the environment. TNO Physics and Electronics Laboratory (TNO-FEL) develops an infrastructure, called Electronic Battlefield Faciliry (EBF), which provides simulation services for development, research and training purposes. The facility provides interoperability of simulators based on the DIS protocol and is able to integrate both high and low-echelon command and control aspects. DIS stands for Distributed Interactive Simulation and is a world-wide standard for simulator interoperability


Digital technology is drastically altering business patterns. Enterprises strive to use these technologies to discover the worth of their consumers while understanding their rivals is required to get a decisive advantage in competitive marketplaces. In this situation, existing competitive intelligence practices require more fundamental theories to underpin them and the awareness to apply these strategies. This study will propose theory-based indicators as criteria to evaluate competitors intelligently through machine learning techniques and depict the competitive landscape using the experts' suggestions. The results reveal that the XGBoost model provides the best performance in evaluating competitors and will be used for a competitive landscape depiction with experts' suggestions. The competitive landscape shows that companies with medium R&D and high R&D are mainly located in Eastern China. In all provinces, Beijing is the most competitive. Given the number and proportion of high-R&D logistics companies, the Beijing market is nearly saturated and presents a high market entry barrier for entrants.


Women in the news are mostly featured in stories about domestic violence, sexual harassment, rape, rape-cum-murder, dowry death than in stories about their professional abilities and expertise. Women in politics are similarly sidelined. Journalists often tend to focus on the love and affair angle of the professionally active women's life rather than her struggle or achievement to have become a successful woman in society. Women deem fit to be considered more for their beauty and glamour in Hindi film industry and sports rather than their strength, brilliance, and intelligence. Further, the political and economic success stories are predominantly covered about men, while women are supposed to be left into lurch when covering such stories by journalists in India.


Abstract This paper describes the changes of shape accuracy in workpiece materials depending on the turning clearance angle. The experiments started from choosing three workpiece materials, SM45C(machine structural carbon steel), STS303(stainless steel) and SCM415 (chrome-molybdenum steel). The experiments showed specifically how features of selected materials changed when they were processed with diverse machining depths, 0.1 mm, 0.2 mm and 0.3 mm, with various negative angles, 0.0˚(-6.0˚), 0.3˚(-6.3˚) and 0.9˚(-6.9˚), and called cutting edge inclinationstarting from a fixed rotational speed, 2,500 rpm, focusing on the feed rate, 0.07 mm/rev and 0.10 mm/rev. The resultsof the accuracy of processing, cylindricity, deviation from coaxiality, etc. were compared using the graph and table.The accuracy of cylindricity in the order of degree 0.0˚ → 0.3˚ → 0.9˚ depending on the workpiece materials showed the best cylindricity when it was 0.9˚. In conclusion, the accuracy improved in specific degrees irrespective of thequality of the materials when the bite negative angles increased. This means that workability improved in these experiments. In addition, the processing shape changed depending on depth of the cut and feed rate.


Objective
To analyze the effect of nursing intervention based on Plan-Do-Check-Action cycle management applied to parturient with abnormal head position.

Methods
From May 2017 to May 2018, 152 patients with abnormal head position who gave birth in Central Hospital of Huanggang City, Hubei Province were randomly selected and divided into experimental group and control group, 76 cases of each group.The control group received routine nursing intervention, and the experimental group received PDCA circulation management on the basis of the control group.The basic conditions of puerpera or fetus, delivery mode and outcome of puerpera, pelvic floor exercise compliance, pelvic floor muscle strength, urinary incontinence and sexual life quality were compared between the two groups.

Results
The experimental group had significantly more vaginal delivery patients than the control group, and the patients with eclampsia and postpartum hemorrhage were significantly less than the control group.There were statistically significant differences between the two groups in pelvic floor functional exercise compliance and pelvic floor muscle strength 3 months after delivery (P<0.05). With the migration of time, the compliance of pelvic floor functional exercise and pelvic floor muscle strength showed a significant improvement trend.After 3 months of production, the pelvic floor exercise compliance and pelvic floor muscle strength of the experimental group were significantly better than that of the control group.The urinary incontinence of the experimental group was significantly better than that of the control group 3 months after the birth, and the quality of sexual life was significantly higher than that of the control group, with statistically significant differences (P<0.05).

Conclusions
PDCA circulation management nursing is better than conventional nursing for the recovery of pelvic floor function, can effectively improve the quality of life of patients.

Key words:
PDCA cycle management; Nursing intervention; Head position abnormality


A method of adult cardio-pulmonary resuscitation based on digitization: 1-120-180-90-2-100-30﹕2-5 was researched to make this difficult cardio-pulmonary resuscitation easy to improve its popu- larizing rate for the common.


Magnetic model studies, rock magnetization, and major element chemical analyses show that unusually large amplitude magnetic anomalies found along the easternmost segment of the Southeast Indian Ridge [zone A] are caused by the high intensities of magnetization of basalts intruded at the ridge axis. In turn, these high magnetizations are caused by a threefold increase in weight percent of titanomagnetites from normal midocean ridge basalts intruded in the west [zones B and C] to ferrobasalts intruded in the high magnetic anomaly zone to the east. The Fe-Ti increase in the opaques reflects a major elemental enrichment in Fe and Ti caused by extensive shallow fractionation of plagioclase, clinopyroxene, and olivine. This shallow fractionation appears related to unusually cold magma crystallization temperatures, perhaps caused by proximity to a postulated downwelling zone in the asthenosphere south of Australia. However, examination of these correlations in greater detail points to several ambiguities: although the entire region is deep, and therefore the lithosphere is integrally colder than normal plates, zone A is shallower than zones B and C, but geothermometrically, its axial magmas are colder. We do not know how cold magmas directly relate to ferrobasalt generation. Also, plumelike geochemical signatures are also seen in some of the analyses. It appears that plume mantle sources are mixing with MORB sources and then undergoing extensive shallow fractional crystallization in zone A.


This study focuses on evaluating the effect of low-rank coal on thermal conductivity, soil moisture, and growth of maize ( Zea mays ) in sodium saline soil. Sodium saline soil is collected from the state of Cesar (Colombia) and soil samples (2 kg) are treated with 0, 2, and 4 t/ha of low-rank coal. The Colombian maize strain ICA 109 is used. Soil thermal conductivity is measured in situ 10 days after establishing the experiment. The results show that adding low-rank coal caused a significant decrease in soil thermal conductivity and a 36% survival rate of maize plants. It is concluded that the 2 t/ha low-rank coal treatment is best for promoting plant growth.


The title reactions have been studied by spectrophotometry.The products of the first and second steps of the substitution reactions are Pt(S2COR)(S2CN(CH2)5)and Pt(S2CN(CH2)5)2 respectively.The reaction order in each of the complexes is unity,and the apparent reaction orders in piperi-dine are in the ranges of 2.0 to 2.6 and 1.5 to 1.9 respectively.A mechanism involving an additive preequilibration was proposed.The rate equation derived from the mechanism explained all of the experimental results satisfactorily.The preequilibrium constants and the rate constants of the rate determining steps were calculated,and the structures of the adducts were discussed and reasonably infered,Activation parameters and isokinetic temperatures(β1=283±7K,β2=263±25K)were calculated.


In mammals, the pineal hormone melatonin is secreted nocturnally and acts in the pars tuberalis (PT) of the anterior pituitary to control seasonal neuroendocrine function. Melatonin signals through the type 1 Gi‐protein coupled melatonin receptor (MT1), inhibiting adenylate cyclase (AC) activity and thereby reducing intracellular concentrations of the second messenger, cAMP. Because melatonin action ceases by the end of the night, this allows a daily rise in cAMP levels, which plays a key part in the photoperiodic response mechanism in the PT. In addition, melatonin receptor desensitisation and sensitisation of AC by melatonin itself appear to fine‐tune this process. Opposing the actions of melatonin, thyroid‐stimulating hormone (TSH), produced by PT cells, signals through its cognate Gs‐protein coupled receptor (TSH‐R), leading to increased cAMP production. This effect may contribute to increased TSH production by the PT during spring and summer, and is of considerable interest because TSH plays a pivotal role in seasonal neuroendocrine function. Because cAMP stands at the crossroads between melatonin and TSH signalling pathways, any protein modulating cAMP production has the potential to impact on photoperiodic readout. In the present study, we show that the regulator of G‐protein signalling RGS4 is a melatonin‐responsive gene, whose expression in the PT increases some 2.5‐fold after melatonin treatment. Correspondingly, RGS4 expression is acutely sensitive to changing day length. In sheep acclimated to short days (SP, 8 h light/day), RGS4 expression increases sharply following dark onset, peaking in the middle of the night before declining to basal levels by dawn. Extending the day length to 16 h (LP) by an acute 8‐h delay in lights off causes a corresponding delay in the evening rise of RGS4 expression, and the return to basal levels is delayed some 4 h into the next morning. To test the hypothesis that RGS4 expression modulates interactions between melatonin‐ and TSH‐dependent cAMP signalling pathways, we used transient transfections of MT1, TSH‐R and RGS4 in COS7 cells along with a cAMP‐response element luciferase reporter (CRE‐luc). RGS4 attenuated MT1‐mediated inhibition of TSH‐stimulated CRE‐luc activation. We propose that RGS4 contributes to photoperiodic sensitivity in the morning induction of cAMP‐dependent gene expression in the PT.


BACKGROUND
Hydrogen sulphide (H(2)S) has recently emerged as a novel and important gasotransmitter in the cardiovascular system, where it is generated mainly by cystathionine gamma-lyase (CSE). Abnormal metabolism and functions of the CSE/H(2)S pathway have been linked to various cardiovascular diseases including atherosclerosis and hypertension. An important role for H(2)S in regulating the balance between cellular growth and death has been demonstrated whereby inhibition of the endogenous CSE/H(2)S pathway results in greater apoptosis of vascular smooth muscle cells (SMCs). H(2)S is increasingly recognized as a critical regulator of vascular integrity, but its role in SMCs during hypoxia has not been explored in a model of CSE deficiency.

METHODS
Cell viability, apoptosis, redox status and mitochondrial activity in hypoxia-exposed (12 h at 1% O(2)) SMCs derived from the mesenteric artery of CSE-knockout (CSE-KO) mice were analyzed. These were compared with those from CSE-wild-type (CSE-WT) mice.

RESULTS
CSE-KO cells exhibited redox imbalance and aberrant mitochondrial activity versus CSE-WT cells, indicating an essential regulatory role for the endogenous CSE/H(2)S pathway on SMC function. CSE-KO cells were also more susceptible to hypoxia-induced cell death, indicating a critical contribution of endogenous CSE/H(2)S pathway to the protective hypoxia stress response.

CONCLUSION
These findings support the concept that H(2)S is a crucial regulator of vascular homeostasis, the deficiency of which is associated with various pathologies, and provide further evidence that H(2)S is a potent vasculoprotectant.


Rosa AR, González‐Ortega I, González‐Pinto A, Echeburúa E, Comes M, Martínez‐Àran A, Ugarte A, Fernández M, Vieta E. One‐year psychosocial functioning in patients in the early vs. late stage of bipolar disorder.


The x‐ray source in high mass x‐ray binaries (HMXB's) provides a unique ''active'' probe of the winds of massive stars. As the binary system orbits around the center of mass, our line of sight changes continuously, allowing us to map the distribution of x‐ray absorbing gas in the system. At the same time, the strong x‐ray flux alters the local dynamics of the wind, providing us with an opportunity to study the physics of radiatively‐driven winds. Some HMXB systems even provide a variable x‐ray source, from which we can measure the effects of a local x‐ray flux. New hydrodynamic models, coupled with recent observations, allow us to take advantage of this natural x‐ray machine, providing new insight into the dynamics of radiatively driven winds. The various physical processes that affect the wind dynamics will be reviewed, as well as the observational consequences of these processes as gleaned from multidimensional hydrodynamic models.


s, Phys.Rev.D22 (1980), 2018. i. M. Luscher and K. Pohlmeyer, Nuclear Phys. B 137 (1978), 46. '. Y.-S. Wu, Nucl. Phys. B 211(1983), 160. I. In a private communication, S. Michailou has stated that the classical initial value ilem for the nonlinear sigma model can be solved using a Riemann-HUbcrt analysis. >. C. N. Yang, Phys. Rev. Lett. 38 (1979), 1377. 1. L. Dolan, Proceedings of XI Internal. Colloq, Group Theoretical Methods in Physics, ibul. Turkey, August 1982.


This article evaluates aspects concerning the system of waste disposal from healthcare services in Alta Floresta (MT) through three stages of analysis. First, we analyzed the pattern of waste management of health services taking for granted in a sample of 21 health care units. Subsequently we analyzed the process of collection and transportation of waste from health services. Finally, the analysis examined the conditions for final disposal at the municipal landfill and the transportation costs for waste disposal in the city of Cuiaba, 840 Km far-away. The exploratory and descriptive study has had a qualitative and quantitative nature through the use of the techniques of literature and document review as well as gravimetric analysis and photographic record in the fieldwork. Throughout these discussions and methodological procedures this paper concludes that the waste disposal system from health services in Alta Floresta presents inefficiencies across the chain although with economic and environmental feasibility for the implementation of


A loop space formulation of Yang–Mills theory highlighting the significance of monopoles for the existence of gauge potentials is used to derive a generalization of electric–magnetic duality to the non-Abelian theory. The result implies that the gauge symmetry is doubled from SU(N) to , while the physical degrees of freedom remain the same, so that the theory can be described in terms of either the usual Yang–Mills potential Aμ(x) or its dual Aμ(x). Non-Abelian "electric" charges appear as sources of Aμ but as monopoles of Aμ, while their "magnetic" counterparts appear as monopoles of Aμ but sources of Aμ. Although these results have been derived only for classical fields, it is shown for the quantum theory that the Dirac phase factors (or Wilson loops) constructed out of Aμ and Aμ satisfy the 't Hooft commutation relations, so that his results on confinement apply. Hence one concludes, in particular, that since colour SU(3) is confined, dual colour is broken. Such predictions can lead to many very interesting physical consequences, which are explored in a companion paper.


Previous learning-based interpolation methods do not consider multi-scale structural information, which is generally effective for image modeling. In this paper, we design a deep network based on a novel pyramid variation learning approach with multi-scale structure modeling. An image is represented as multi-dimensional features. Besides two spatial dimensions, the features include a neighboring variation dimension where every pixel is encoded as the variation to its nearest low-resolution pixel, and a scale dimension along which the feature maps generated by a gradual down-sampling process are stacked. Thus, these multi-dimensional features are constructed to model local dependency and multi-scale similarity jointly. Inspired by this feature design, we build an end-to-end trainable Recurrent Multi-Path Aggregation Network (RMPAN) for image interpolation, where the scale dimension is unfolded to form a multi-path aggregation network to apply joint filters at different scales recurrently. Location aware sampling layers are used in RMPAN to transform feature maps into different scales with only location changes in each convolution path, which aggregate the context information without resolution loss. Comprehensive experiments demonstrate that our method leads to a superior performance and offers new state-of-the-art benchmark.


In the dark of night, aviation firefighters, ambulance personnel and staff from Cairns Hospital mobilised to respond to the crash of an aircraft off the far north coast this week. Lucky enough for everybody involved, this was just a drill.


The present invention relates to an anti-ice / de-icing (13) an outer surface (11) of a structure likely to be iced, such as a wing or an aircraft nacelle, a manufacturing process of this and such a system incorporating the structure. This anti-icing system / defroster comprises an inner layer (14) thermally insulating a metallic intermediate layer (15) which covers it and which is intended to be connected to electrical supply means so as to form a heating resistor, and an outer layer (16) electrically insulating and thermally conductive covering the metal layer. According to the invention, this metallic layer is obtained by vacuum deposition of at least one metal on a substrate defined by said inner layer or said outer layer, said vacuum deposited metal layer having a thickness evenly between 0.02 microns and 10 microns and a surface resistivity of between 0.04 and 4 ohms per square, so that this system has in particular a minimized thermal inertia and an optimized power flux density.


As we known that global warming results in happenings of extreme weathers, including extreme hot weathers. The mean temperatures anneal increase from 1880 to 2000 in general, especially in the duration of 1961-2000, within which there was significant drop in crop yields [1], though drop in yields resulted from complexed impacts in combination of temperature and other kinds of environmental factors.


This document is the third chapter in a Population Council publication describing findings from 12 situation analysis studies conducted in 1995 to determine the quality of clinic-based family planning (FP) and reproductive health services in 11 countries of sub-Sahara Africa since 1989. This chapter presents an overall picture of the quality of FP services in the region in its presentation of basic findings from the 12 studies. It includes over 100 indicators that reflect program readiness and quality of services delivered. The chapter identifies several consistent program strengths including 1) the serviceable infrastructure of most service delivery points 2) an appropriate pattern of methods offered (except for lack of full availability of condoms in some countries) 3) inventory control (except for injectables) 4) consistent physical assessments of new clients 5) high quality aseptic injections and 6) scheduling revisit dates with clients. Overall weaknesses that require attention include 1) a lack of counseling on FP 2) a failure to incorporate consistent aseptic procedures and 3) failure to address a clients sexually transmitted disease or HIV risk adequately.


Despite multiple initiatives medication adherence rates remain low. The Medication Adherence Expertise Center of the northern Netherlands aims to change that. This article provides an overview of the center's activities.


The present invention discloses a massager lacrimal sac, rod-shaped form made of a medical silicone, one end of the rod-like body is in contact with the thin end of the eye, the other end of the rod-shaped member for holding the butt end. Reasonable in structure, easy to use, non-invasive, good health, work results.


In this paper, a new type of indoor air purification device was designed. Corona discharge combined with catalysis and physical adsorption was used in this device. Formaldehyde (PA), a typical indoor air pollutant, was chosen as the model pollutant. The effects of MnO2 in degradation of PA by electrical discharge were discussed. The results showed that corona discharge can effectively remove PA, and the addition of MnO2 can not only accelerate the degradation rate, but also solve the problem of excessive ozone (O3). Besides, the corona discharge plasma also has the function of in-situ cleaning for MnO2. The new reactor has the characteristics of high efficiency, energy-saving, without secondary pollution.


Thermodynamic properties of complexes of Congo Red (CR) dye with amyloid  (A) peptides were studied by both absorption spectroscopy and isothermal titration calorimetry (ITC). Based on the absorption spectrum for the formation of CR-Aβ complexes in phosphate buffered saline solution (pH 7.4), van't Hoff plots over a temperature range of 10oC to 70oC were created for CR-Aβ1-40, -Aβ12-28, and -Aβ1-42. The plot for CRAβ12-28 complex showed a relatively linear feature within the given temperature range with H = –10.1 0.6 kJ/mol and S = + 0.128  0.002 kJ/(mol K). However, the plot for CR-Aβ1-40 and CR-Aβ1-42 complexes exhibited two distinct linear regions with opposite slopes centered at a specific temperature, Ts, which was 54.7  0.2℃ and 34.8  0.2℃, respectively. The ITC experiments conducted at 25℃in water exhibited quite a different situation from the above mentioned spectroscopic approach. The ITC studies yielded a H of –85.3  0.2 kJ/mol for the CR-Aβ12-28 complex with negative entropy change –0.152 kJ/mol K). For CR-Aβ1-40, the ITC studies indicated the presence of two binding sites with H1 = –81.8  0.3 kJ/mol and H2 = –119.5  0.2 kJ/mol with K1 = 5.5  0.7  10 6 M -1 and K2 = 6.9  2.4  10 8 M -1 , respectively. These binding constants are consistent with the model suggested by several studies. Both binding sites showed negative entropy changes suggesting that the formation of the complex is enthalpically driven. The disagreement in thermochemical values between two different methods confirmed that the enthalpy and entropy are heavily dependent on temperature and buffer/salt environment, and may involve inherently different reaction paths.


This paper summarises the current state of understanding on Evolution of Automobile Fuels. It explains how the fuels for automobiles have changed over the years since steam as a fuel to biodiesel as a fuel. It also explains what the future of alternative fuels in India is. This paper also shows a comparison between different fuels.


One year's patient data from an urban teaching hospital was retrieved from the computer tapes of a large abstracting service. A variable but significant error rate was found in the recording of each entry studied. Such errors caused the data to be unsuitable for a quality of care study since the error rate was either very high or there was evidence of a recording bias. In either case, chart review would have been required and thus the data would have been, at best, only a guide to selecting parameters to study in a chart review. The »information« obtained was so obviously inaccurate that it is unlikely that anyone would consider using it. However, in-hospital monitoring of data summaries received from the abstracting service might well lead to the elimination of obvious errors while retaining plausible but still inaccurate data. The acceptance of such could lead to serious false conclusions. For example, our »data« suggested that ward patients and non-ward patients received a different quality of care, a result not confirmed by chart review. Given the system used, it was concluded that possible errors in data recording could be recognized most efficiently through »check« programs at the abstracting service and that by using such programs, the abstracting service could and should initiate improvements in hospital practices and coder training to minimize errors.


This e-working paper aims at raising the awareness to Communication for Development as a concept whose relevance has been widely acknowledged by the United Nations Organisation, who keeps highlighting community radios as tools for civic partaking on the public sphere and as faithful guarantors of human rights and freedoms in contexts featuring extreme poverty, as well as fighting isolation, apathy and information exclusion generated by Globalized Information and as multi-sector tools for social and economic development that are vital to meeting the Millennium Development Goals.


Bounds on the minimum number of data transfers (i.e., loads, stores, and copies) required by WFTA and FFT programs are presented. The analysis is applicable to those general-purpose computers with M general processor registers (e.g., the IBM 370, PDP-11, etc.) where 4 \leq M \ll transform length. It is shown that the 1008- point WFTA requires about 21 percent more data transfers than the 1024-point radix-4 FFT; on the other hand, the 120-point WFTA has about the same number of data transfers as the mixed radix (4 × 4 × 4 × 2) version of the 128-point FFT and 22 percent fewer than the radix-2 version. Finally, comparisons of the "total" program execution times (multiplications, additions, and data transfers, but not indexing or permutations) are presented.


+ In the pages of this quarterly in 1954, Justus M. Van der Kroef traced the history of the press in Indonesia up to that time.1 In his article, Van der Kroef, a noted and prolific writer on Indonesia, concluded that the future of Indonesian journalism depended, in large part, on the guidance which could be given by the nation's "more thoughtful" political leaders who had a clear idea of the function of the press in a democratic country. Unfortunately, both for Indonesia and its press, constitutional democracy survived in the Southeast Asian nation only until 1957 when President Sukarno began his system of one-man rule under the name "Guided Democracy." The decline of parliamentary government can, in part at least, be laid to the Indonesian press and the ultimately disintegrative effect which it had on its society. It is the purpose of this paper to analyze that phenomenon and the fate of Indonesian journalism under a


In La venganza de Tamar, Tirso de Molina constructs true tissues through the poetic word, by bringing up the resources that appeal to the imagination, the visualization and the senses of the audience. Among them, the chromatic component of painting, the narrative and allegorical efficacy of the images, the specular play of gaze, the optical illusion, as well as the chiaroscuro technique. In other words, the theatricality of art with purpose of warning his diverse audience on the bad consequences of lust and gluttony. In this way, Tirso accomplished his mission as a deus pictor. In this essay I intend to illustrate how Tirso creates a true dramaturgy of the image, making painting to speak in/ and with poetry.


Heat transfer coefficient in gravity controlled condensation on a horizontal tube is enhanced by coiling a wire around the tube, because the condensate film between the coiled wires thins. An analytical solution is derived form simplified simultaneous differntial equations. Two coefficients which are contained in the solution are determined from experimental results for RII and ethanol vapours. Maximum heat transfer coefficient is obtained at the ratio of pitch to diameter of wire equal to two, and the increment ratio to a smooth tube is inversely proportioinal to one-fourth power of capillary constant. The present device will be usuful to the condenser for organic substances.


Objective: To investigate the phenotype diversity and dominant species of yeasts during spontaneous fermentation process of Musalais from Xinjiang,and explore the effect of traditional technology on yeast community.Methods: A total of 19 samples were collected from the traditional spontaneous fermentation process of Musalais(including grapes,grape juice,boiled juice and fermentation broth) to analyze yeast phenotype diversity and corresponding dominant species.The isolated strains from these samples were typed and representative strains were selected for colony characteristic analysis on Wallerstein laboratory nutrient agar(WL nutrient agar) and grouped by unweighted pair group method with arithmetic mean(UPGMA) method and primarily identified according to their morphological and physiological characteristics.Results: Totally 217 isolates,13 types based on WL agar culture,and 8 phenotype groups from 13 representative strains were harvested.Meanwhile,7 generaand 13 species were primarily identified.The diversity of yeasts was associated with spontaneous fermentation of Musalais.Hanseniaspora spp.was the dominant strain in grape skin,grape juice and boiled grape juice.Saccharomyces cerevisiae is a starter and the only dominant strain during spontaneous fermentation of Musalais;however,other yeast species were also occasionally observed in fermentation broth.Conclusion: Almost all yeasts from grapes are killed by boiling during the production of Musalais.S.cerevisiae may come from brewing utensils and locations,and has high adaptability to spontaneous fermentation of Musalais.


Aim: Determine the prevalence of sensorineural hearing loss (SNHL) and relate this to cumulative exposure to hypoxia, hypocapnia and hypotension. Describe chronic health problems among 5‐ to 11‐year‐old children treated for persistent pulmonary hypertension of the newborn (PPHN).


In this Paper, the author proved the theorem: Let f(z)be an nonconstant periodic function of exponential type and positive lower order, and g(z) be an entire function of finite order If g(z) is permutable with f(z), then g(z)≡f(z)or g(z)≡z


Little is known about the impact of blood‐pool local impedance (LI) on lesion characteristics and the incidence of steam pops.


Call a disjunction of k Boolean variables a k-clause. For a set V of n Boolean variables, let Ck(V ) denote the set of all 2n possible k-clauses on V . A random k-CNF formula Fk(n,m) is formed by selecting uniformly, independently and with replacement m clauses from Ck and taking their conjunction. The study of such random k-CNF formulas has attracted substantial interest in logic, optimization, combinatorics, the theory of algorithms and, more recently, statistical physics. We will say that a sequence of events En occurs with high probability (w.h.p.) if limn→∞P[En] = 1 and with uniformly positive probability if lim infn→∞P[En] > 0. We emphasize that throughout the paper k is arbitrarily large but fixed, while n→∞. For each k ≥ 2, let rk ≡ sup{r : Fk(n, rn) is satisfiable w.h.p.} , r∗ k ≡ inf{r : Fk(n, rn) is unsatisfiable w.h.p.} . Clearly, rk ≤ r∗ k. The Satisfiability Threshold Conjecture asserts that rk = r∗ k for all k ≥ 3. Our main result establishes an asymptotic form of this conjecture. Theorem 1. As k →∞, rk = r∗ k(1− o(1)) . As we will see in Section 1.1, a classical and very simple argument gives r∗ k ≤ 2 log 2. The following theorem implies that this bound is asymptotically tight. The theorem also sharpens the o(1) term in Theorem 1.


This essay examines the perplexing triangular relation between Henri Michaux's ambiguous and attenuated lyricism, the French lyrical tradition, and Michaux's Chinese-inspired poems. I explore how Michaux's West-Eastern cross-cultural straddling relates to the way he renders the lyric problematic, and how this relation can help us re-read and perhaps unread the lyric (at least, its European understanding) in a comparative way. I first read some poems that are representative of Michaux's uneasy and disintegrating lyricism; then I consider how Michaux's poems that allude to Chinese and Far Eastern sources of inspiration reinstate his lyric voice, but in a new, 'Asianised' way. This raises the intriguing question of why there exists a coincidence between Michaux's 'Chinese-style' and his lyrical moments. Besides considering Michaux's Chinese influences and the Orientalist stereotyping of Chinese literary style, I argue that a stronger comparative approach to this question is to consider lyricism in the Chinese context and how shuqing (approximately translated as 'lyrical') writing – despite its very different conceptual framework – may shed light on Michaux's poetry and dislodge Eurocentric views of the lyric. Finally, I propose that Michaux's poetry marks the point of simultaneous lyric disintegration and reformulation. Although Michaux's Chinese-inspired dimension sustains certain lyrical moments, the transcultural aesthetics of his West-Eastern lyric in fact resists fusion and reconciliation, presenting instead a juxtapositional tension and splintering of poetics between Michaux's French and Chinese sides.


The invention relates to a fiber porcelain light-weight function board and a preparation method thereof, and belongs to the field of a building material. The fiber porcelain light-weight function board consists of an unfoamed inorganic material layer and a foamed inorganic material layer, wherein according to a material formula of the foamed inorganic material layer, limestone, plaster, silicon carbide powder or glass powder is mixed in the conventional porcelain raw material; for the mixing proportion, 10 to 35 parts of limestone, plaster, silicon carbide powder or glass powder are included in 100 parts of raw materials, and the rest is the conventional porcelain raw material; the unfoamed inorganic material layer and the foamed inorganic material layer are fired into a whole through once high-temperature sintering; after the high-temperature sintering, the thickness of the unfoamed inorganic material layer is 3 to 5mm, and the thickness of the foamed inorganic material layer is 60 to 200mm; the length and width dimension proportion of the single fiber porcelain light-weight function board is 2:1; and the specific gravity of the fiber porcelain light-weight function board is 0.5 to 0.6. The fiber porcelain light-weight function board has the functions of heat insulation and sound isolation, is suitable for finishing and decoration of internal and external wall surfaces of a building, or is used for building partition walls among all rooms inside the building.


This paper proposes a 10 b 200 MS/s pipeline analog-to-digital convertor (ADC) for high-quality video systems based on double-channel and op-amp sharing schemes to minimize power consumption and channel mismatch. The double channel time-interleaved scheme reduces the required operating speed of amplifiers in the sample-and-hold amplifier and multiplying digital-to-analog (D/A) converters by 50%. The switched and shared op-amp with two input pairs amplifies each channel signal without extra series switches while minimizing the gain, bandwidth and offset mismatches between channels. The low-jitter sampling clock with a 50% duty cycle improves the dynamic performance of the wideband input signals significantly. The Flash ADCs employ a differential difference amplifier type pre-amp to continuously process dual-channel outputs. The prototype ADC in a 0.18 μm CMOS technology demonstrates the measured differential nonlinearity and integral nonlinearity within 0.62 and 0.99 LSB, respectively. At 200 MS/s, the ADC shows a maximum SNDR of 52.8 dB and a maximum SFDR of 60.4 dB. The ADC with an active die area of 1.28 mm2 consumes 54.0 mW at 1.8 V.


Objective: To evaluate the efficacy and toxicity reactions of etoposide capsules in treatment of extensive small-cell lung cancer(SCLC).Methods: To select 40 cases single oral drug etoposide capsule 100 mg / day for 10 to 14 days for treatment interval of 3 to 4 weeks repetition,the use of more than 2 treatment.Results: The response rate was 52%.The main toxicity reactions were nausea/vomiting、alopecia and hematologic toxicity.Conclusion:The etoposide capsule is a highly effective regimen for patients with extensive small-cell lung cancer,with a manageable toxicity.


Abstract Sequences of the plastid maturase (matK) and nuclear chalcone synthase (Chs) were analyzed separately and in combination to assess phylogenetic relationships of Solms-laubachia Muschl. (all nine known species and two undescribed ones) to the genera Baimashania Al-Shehbaz, Parrya R. Br., Desideria Pamp., Leiospora (C. A. Mey.) Dvořák, Christolea Cambess., and Phaeonychium O. E. Schulz (Brassicaceae). Baimashania is clustered with Aubrieta deltoidea (L.) DC. and Arabis blepharophylla Hook. & Arn. Solms-laubachia, Desideria, Leiospora, Christolea, and Phaeonychium are more closely related to Matthiola R. Br. than to Parrya, and they form a well-supported clade. Within this clade, Leiospora is sister to a subclade containing the sister groups Christolea and Solms-laubachia s.l. The Solms-laubachia s.l. group contains Solms-laubachia, Desideria, and a species of Phaeonychium. Neither Solms-laubachia nor Desideria is monophyletic, whereas Phaeonychium jafrii Al-Shehbaz is embedded within the group. Therefore, our results suggest that Solms-laubachia be expanded to include Desideria and P. jafrii. Nevertheless, more species of Desideria, Parrya, and Phaeonychium are needed to further test our findings.


Significance Voltage-gated sodium channels are one of the most fundamental electrical components in the nervous system and are key targets for local anesthesia and therapeutics for neurological and cardiac disorders. We have used multimicrosecond simulations to provide molecular-level descriptions of sodium channel function. We describe an almost barrier-less three-ion conduction mechanism involving competing knock-on and "pass-by" processes, intimately linked to signature glutamate ring protonation and structural isomerizations. These simulations have uncovered a high degree of protein flexibility, with conformational fluctuations in the pore domain involving residues central to slow-type inactivation, leading to gate collapse, helix bending, filter disruption, and changes in lipid-facing fenestrations linked to Nav drug pathways. Voltage-gated Na+ channels play an essential role in electrical signaling in the nervous system and are key pharmacological targets for a range of disorders. The recent solution of X-ray structures for the bacterial channel NavAb has provided an opportunity to study functional mechanisms at the atomic level. This channel's selectivity filter exhibits an EEEE ring sequence, characteristic of mammalian Ca2+, not Na+, channels. This raises the fundamentally important question: just what makes a Na+ channel conduct Na+ ions? Here we explore ion permeation on multimicrosecond timescales using the purpose-built Anton supercomputer. We isolate the likely protonation states of the EEEE ring and observe a striking flexibility of the filter that demonstrates the necessity for extended simulations to study conduction in this channel. We construct free energy maps to reveal complex multi-ion conduction via knock-on and "pass-by" mechanisms, involving concerted ion and glutamate side chain movements. Simulations in mixed ionic solutions reveal relative energetics for Na+, K+, and Ca2+ within the pore that are consistent with the modest selectivity seen experimentally. We have observed conformational changes in the pore domain leading to asymmetrical collapses of the activation gate, similar to proposed inactivated structures of NavAb, with helix bending involving conserved residues that are critical for slow inactivation. These structural changes are shown to regulate access to fenestrations suggested to be pathways for lipophilic drugs and provide deeper insight into the molecular mechanisms connecting drug activity and slow inactivation.


s presented at the Australia & New ZealandMicrocirculation Society/Australian Vascular Biology Society Joint Symposium 5th-8th September 2013, Barossa Valley, South Australia ORAL PRESENTATIONS KEYNOTE LECTURE OP-01 Endothelial junctions in vascular permeability control and leukocyte extravasation D Vestweber Max-Planck-institute of Molecular Biomedicine, M€ unster, Germany The stability of endothelial junctions is centrally dependent on the adhesive function of VE-cadherin. We have recently shown that knock in mice expressing a fusion protein consisting of VE-cadherin and a-catenin instead of wt VE-cadherin are strongly impaired in the induction of vascular permeability and the recruitment of leukocytes into inflamed tissues. This established that the opening of junctions is crucial for both processes and that VE-cadherin is a central molecular target in inflammation. In vitro studies have suggested that the phosphorylation of VE-cadherin and the catenins is involved in the induction of transendothelial permeability and transmigration of leukocytes through cultured endothelial cell layers. In agreementwith this, we found that the endothelial specific receptor type protein tyrosine phosphatase, VE-PTP, associates with VE-cadherin and supports its adhesive function. Induction of permeability and transmigration of leukocytes both trigger the dissociation of VE-PTP from VE-cadherin and we have shown that this dissociation is necessary in vivo for the opening of endothelial junctions. More recently we identified the signaling pathway in endothelial cells that drives this dissociation process. To analyze the relevance of tyrosine phosphorylation of VEcadherin for the regulation of endothelial junctions in vivo, we have generated knock in mice where certain tyrosine residues in VE-cadherin were replaced by phenylalanines. In addition, we generated specific antibodies for each of these different phosphorylated tyrosines within VE-cadherin. Surprisingly, we found differential regulation of the phosphorylation of these residues in vivo. Furthermore, analysis of the induction of vascular permeability and leukocyte recruitment in the different knock in mice revealed distinct roles for different tyrosine residues. More recently, we have now identified the mechanism whereby leukocytes downregulate the function of VE-cadherin by regulating its tyrosine phosphorylation. INFLAMMATION AND WOUND HEALING OP-02 Novel actions of regulatory T cells in the microvasculature MJ Hickey, LD Abeynaike, CLV Westhorpe and JA Deane Centre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical Centre, Clayton, Victoria, Australia Regulatory T cells (Tregs) are a subset of CD4 T lymphocytes that limit inflammation in peripheral tissues. Studies of the skin show that in order for Tregs to inhibit inflammation, they must be able to undergo interactions in the dermal microvasculature. Despite this, little is known regarding the interactions whereby these cells undergo recruitment. Therefore, the aim of these studies was to examine Treg trafficking in a model of dermal inflammation, using confocal intravital microscopy to examine Treg-endothelial interactions. Foxp3-GFP mice were used to enable visualisation of Tregs in vivo. Tregs underwent rolling interactions on the endothelium, although these were minimally altered during inflammation. Treg rolling was generally mediated by endothelial Pand E-selectin in tandem. Tregs were also observed to undergo adhesion, representing ~40% of the total adherent CD4 T cells at the peak of the response. Treg adhesionwas eliminated by ICAM-1 inhibition, a response associated with increased adhesion of pro-inflammatory leukocytes. Time lapse observations of adherent Tregs revealed that some Tregs underwent transmigration, but only at certain time points in the response. At other times, Tregs underwent prolonged intravascular crawling, but failed to transmigrate. Together these observations demonstrate the complexity ofTreg-endothelial cell interactions during aT cellmediated inflammatory response, and suggest that one mechanism whereby Tregs control inflammation in the periphery is via regulation of endothelial cell adhesive function. These studies were approved by the Monash Medical Centre 'B' Animal Ethics Committee. a 2014 John Wiley & Sons Ltd 435 DOI:10.1111/micc.12149


It is necessary to reform higher vocational education and teaching.Setting up a new modern system of higher vocational education and teaching is an urgent demand and inevitable request of the development of market economy.In addition,it is also a demand to the development of higher vocational education of its own.There are four purposes primarily in setting up the new modern system of higher vocational education and teaching.Several things should be done in carrying out higher vocational education and teaching reform and also correctly handling several relationships.


A newly developed lipid-packaged one-dimensional complex of platinum shows solvatochromism in organic media. The use of anionic lipids as counter anions is indispensable for the solvent-dependent control of one-dimensional electronic states, aggregate morphology and thermal stability.


High precision and high efficiency in robotic grinding of aero-engine extremely thin blade edges is a challenging problem. In this article, a novel toolpath planning method is proposed based on the derived dwell time calculation model and the developed interpolation algorithm. The dwell time of each cutter contact point is solved based on the matrix method by consideration of the revised material removal model and machining allowance distribution. To optimize the previous interpolation algorithm based on geometric intersection, an arc length and Taylor binary expansion optimization are proposed to plan cutter contact points according to the dwell time and the curvature changes of blade edges. Subsequently, the tool orientation is corrected based on a double-vector controlling method to avoid the processing interference. Simulation results show that the proposed interpolation algorithm has improved the path coverage by 17.6%, and its computational efficiency is 34 times higher than that in previous algorithm. The comparative robotic grinding experiment results show that the proposed toolpath has improved the surface profile accuracy of blade edge to 0.042 mm, and its machining accuracy is 14.3–46.2% higher than that of other methods.


We are developing an automated method to identify the best quality segment among the corresponding segments in multiple-phase cCTA. The coronary artery trees are automatically extracted from different cCTA phases using our multi-scale vessel segmentation and tracking method. An automated registration method is then used to align the multiple-phase artery trees. The corresponding coronary artery segments are identified in the registered vessel trees and are straightened by curved planar reformation (CPR). Four features are extracted from each segment in each phase as quality indicators in the original CT volume and the straightened CPR volume. Each quality indicator is used as a voting classifier to vote the corresponding segments. A newly designed weighted voting ensemble (WVE) classifier is finally used to determine the best-quality coronary segment. An observer preference study is conducted with three readers to visually rate the quality of the vessels in 1 to 6 rankings. Six and 10 cCTA cases are used as training and test set in this preliminary study. For the 10 test cases, the agreement between automatically identified best-quality (AI-BQ) segments and radiologist's top 2 rankings is 79.7%, and between AI-BQ and the other two readers are 74.8% and 83.7%, respectively. The results demonstrated that the performance of our automated method was comparable to those of experienced readers for identification of the best-quality coronary segments.


Recently we proposed the linguistic interpretation of quantum mechanics (called quantum and classical measurement theory), which was characterized as a kind of metaphysical and linguistic turn of the Copenhagen interpretation. This turn from physics to language does not only extend quantum theory to classical systems but also yield the quantum mechanical world view (i.e., quantum philosophy or quantum language). The purpose of this paper is to formulate the double-slit experiment, the quantum eraser experiment, Wheeler's delayed choice experiment, Hardy's paradox and the three boxes paradox (the weak value associated with a weak measurement due to Aharonov, et al.) in the linguistic interpretation of quantum mechanics. Through these arguments, we assert that the linguistic interpretation is just the final version of so called Copenhagen interpretation. And therefore, we conclude that the Copenhagen interpretation does not belong to physics (i.e., the realistic world view) but the linguistic world view.


Optical Parity-Time (PT-) symmetric systems support unusual properties when the symmetric coupling between internal modes is broken. We propose a new class of quasiperiodic PT-axisymmetric systems which lead to a simultaneous extraordinary field enhancement and localization at the symmetry center. The effect is based on the asymmetric radial coupling of outward to inward propagating waves of the complex structure. We explore such optical potentials in 1D and 2D combining gain/loss and index modulations, which could have actual realizations in nanophotonic structures. As a direct application, we show how to render a broad aperture vertical-cavity surface-emitting lasers (VCSEL) into a bright and narrow beam source.


The present invention relates to a method of using the sum of recognizing CDw52 antigen for the treatment of treatment of T- cell mediated inflammation of the hwanjeol, especially rheumatoid arthritis. Antibody and a humanized antibody CAMPATH-1H preferably, this can be used in conjunction with immunosuppressive agents such as steroids or other immunosuppressive antibody.


This explorative study is an assessment on empowerment of female tea garden workers through capabilities approach analysis. This study is conducted in a tea estate in Sylhet named Dholdoli. This study has shown that empowerment, in most cases, is found affirmative. Besides reviewing related literature and past research reports, the study is mainly based on primary field data. This study has collected qualitative data following an in-depth interview method of research. The tea garden has been selected purposively. For acquiring qualitative data, the study has involved a number of research participants, such as workers, management staffs, employers, union leaders, buyers and other local stakeholders. The study will mainly focus on in-depth interview techniques. Results show that most of the respondents have control over their own income (including expenditure and saving) but as they have been paid in low amounts, they can hardly save anything, also they exhibit very explicitly that they have a participation in the decision of their child schooling, family planning, and other facts in social and political issues. They can participate in their local panchayet at or even in national election without any pursuing of a male member of their family. Original Research Article Aktar et al.; SAJSSE, 6(3): 9-18, 2020; Article no.SAJSSE.56228 10


Sorption of phthalic acid, chelidamic acid, and sulfate onto goethite (α-FeOOH) was examined in single-sorbate and in sulfate−organic acid binary-sorbate systems to determine the extent of competition between the simple organic acids and sulfate. Sorption characteristics of sulfate and the organic acids were similar and resembled those reported for humic substances onto oxides. Sorption data for all three sorbates over a wide range of conditions (pH, I, sorbate/sorbent ratio) were described quantitatively by the generalized two-layer model with a unique set of surface reactions and equilibrium constants for each sorbate. Sorption affinities of sulfate and the organic acids were comparable, and sulfate effectively competed with the organic acids for surface sites on goethite, particularly at low pH. These results suggest that sulfate can significantly influence the sorption of simple organic acids and humic substances in natural aquatic systems. Predictions of sorption in binary-sorbate systems based on si...


Solid state polymer electrolytes based on the nanostructured block copolymers including the con-ventional ionic liquid which have different alkyl chains were prepared. The site selectivity of ionic liquids in the nanostructured polymer matrix has been investigated by thermal properties and ionic conductivity. The glass transition temperatures of polymer electrolytes showed interesting behavior by adding suitable ionic liquids. Owing to the high affinity of the ionic liquids which have long alkyl chain for hydrophobic polymer, the PnBA phase of block copolymers was selectively plasticized by 1 Decyl 3 methylimidazolium bis ( trifluoromethanesulphonyl ) imide. This site selectivity results that the improvement in ionic conductivity by adding suitable ionic liquids.


Quick Response Code Indonesian Standard (QRIS) is a server-based payment system that uses scans of QR Codes integrated into payment applications. QR Code is a series of codes that contain the user's identity, payment amount, and amount of money and can be read during transactions with certain tools. The research used in this study is quantitative research with an associative approach. The sampling method is based on certain criteria or considerations because the population in this study is the entire generation z Muslims domiciled in NTB, where the actual number is unknown data collection in this study by distributing questionnaires by purposive sampling using the Cochran formula using 100 respondents. The data analysis technique used in this study uses Partial Least Square-Structural Equation Modeling (PLS-SEM). The results of the analysis conducted in the research can be concluded that the factors that influence the use of QRIS BSI are religiosity factors that have a positive and significant influence on the interest in using QRIS BSI in NTB because people in NTB have high religiosity which adheres to Islamic values. The people of NTB will prefer products that are by the teachings of Islam contained in BSI's QRIS. Meanwhile, convenience, knowledge, benefits, and risks have a positive but insignificant effect on the interest in using BSI's QRIS in NTB.


With the development and application of H.264 standard, the technology of H.264-based video data security becomes increasingly important. This paper proposes a new selective encryption scheme based on H.264, it combines the AES OFB mode with the sign encryption algorithm, and encrypts DCs and parts of ACs respectively. This method not only keeps advantages of former selective encryption algorithms in computational complexity and error-propagation prevention, but also efficiently make up for the deficiency in security and compression performance. Experimental results show that the proposed method exhibits low complexity and good security, and it has little effect on compression ratio and supports error- propagation prevention. Moreover, it is suitable for secure transmission of mobile multimedia and wireless multimedia network based on H.264.


Abstract This series of patients has been published in the neurosurgical literature earlier this year, detailing multiple aspects of both the surgical technique and postoperative outcomes. Our aim in this series is not to revisit all the aspects of this publication, but rather to analyze more specifically the benefits of this procedure as it pertains to the preservation of neurological structures of vision—specifically the optic chiasm—and provide a more detailed analysis of visual outcomes in these patients.


It is quite common to refer to al-Ghazālī as one of the most important thinkers in the Islamic intellectual tradition. Aladdin M. Yaqub's Al-Ghazālī's Moderation in Belief: al-Iqtiṣād fī al-i'tiqād shows that this remark is not hyperbolic. And this volume has many characteristics of a good translation of classical texts. First of all, Aladdin M. Yaqub is very consistent with his use of terminology. He explains his preferences for Arabic philosophical terms in "Note on the Translation" (p. xi). As is well known, Moderation in Belief is the first text in which classical Greek logic is systematically used in Islamic theology (see the "Fourth Introduction: On explaining the methods of proof that we employ in this book" [pp. 14 –23]). As a logician, Yaqub is very sensitive to Arabic logical terms when he translates into English. Also, the "Translator's Introduction" gives useful information on al-Ghazālī's life, his thought, and his place in the Ash'arī Kalām. Yaqub's "Interpretive Essay" at the end of the volume is also very helpful in explaining the context of the text. With this essay and notes, the text more easily addresses contemporary readers. But this does not mean that Yaqub turns al-Ghazālī into a modern philosopher. If we think that the study of the Islamic intellectual legacy is restricted mainly to Middle East departments in English-speaking universities, Yaqub's notes provide a challenging academic genre. For example, he refers to Western philosophers like Descartes, Spinoza, Hume, Kant, Austin, Strawson, and Searle throughout. Especially ingenious is the comparative discussion between the speech-act theory in analytical philosophy and al-Ghazālī's arguments. It might even be said that al-Ghazālī's method of resolving issues in philosophical theology is very similar to that of Wittgenstein. As a philosopher, whenever I read Moderation in Belief, it reminds me of Wittgenstein's famous remark in the Philosophical Investigations, "philosophical problems arise when language goes on holiday," and his suggestion to return to ordinary language. In a sense, Moderation in Belief treats theology as grammar. At the very beginning of the book, al-Ghazālī outlines this principle when he explains the methods of proof that he employs:


A field experiment was conducted to study the impact of foliar spray of urea and potassium sulphate during phenological water deficit on the growth and yield of wheat crop. The soil moisture stress at CRI, tillering and flowering stage reduced the grain yield by 25.9, 8.2 and 12.5% respectively over control. Foliar spray of potassium sulphate was effective in improving the grain yield by 6.5-9.1%. Plant growth parameters like plant height and tillering were significantly reduced under water deficit at CRI and tillering stages. Grain filling was affected by stress at flowering but length of panicle and grain number remained unaffected at tillering and flowering. Crop sensitivity to phenological water stress in sandy loam soil was in the order of CRI > flowering > tillering stage.


The article is devoted to the study of scientific opinions of European and Latin American philosophers on the essence of the intercultural philosophy. The issue of the role of the intercultural philosophy in the search of solutions of global problems is also actual.


Abstract Latex vacuoles of Chelidonium majus (Papaveraceae) naturally sequester protoberberine and benzophenanthridine alkaloids. Isolated vesicles take up a number of other heterologous alkaloids, such as 9,10-dihydroergocryptine, vinblastine, strychnine, nicotine, colchicine, lupanine, and 13-hydroxylupanine, with a strong preference for the indole alkaloids and for nicotine. Kinetic data clearly show that the uptake proceeds via simple diffusion and not by carrier-mediated transport. The alkaloids are concentrated in the vesicles against a concentra tion gradient. MgATP has no influence on alkaloid uptake. It is likely that alkaloids are trapped in the vesicles by chelidonic acid (concentration in latex 58 mM, in vesicles 661 mM) which com plexes these alkaloids and thus prevents their rediffusion out of the vesicles. Uptake of these alkaloids by leaf protoplasts and vacuoles of Ch. majus, by vacuoles of suspension-cultured cells of Lupinuspolyphyllus and by rabbit erythrocytes was studied for comparison.


Compared with other components, actuator fault has a higher probability of occurrence in semi-active suspension with magneto-rheological (MR) damper, which will lead to the safety and reliability of the system. Hence, the fault diagnosis and fault-tolerant methods of semi-active vehicle suspension system with MR damper are investigated in this paper to deal with the fault of MR damper. Firstly, the quarter-vehicle suspension system model is established. Secondly, an unknown input observer (UIO) with strong robustness and simple structure is employed to detect the fault of MR damper; meanwhile, the correlation coefficient method based on the system residuals is used to isolate the fault of MR damper. Lastly, the skyhook fault-tolerant controller (FTC) is designed to compensate the system with fault application. The simulation results under sine excitation, random excitation and bump excitation show that the performance of the proposed FTC always outweigh that of without fault-tolerant when MR damper occurs fault.


Resumen en: (Ti,Al)N/Mo multilayers have been deposited by dc magnetron sputtering on high-speed steel and silicon substrates. Experimental X-ray diffraction (XRD) a...


On the basis of Pt/InAlAs metal–semiconductor (MS) structure, an interesting hydrogen sensor is fabricated. The Pt/InAlAs Schottky diode-type hydrogen sensor studied exhibits significant sensing performance including high relative sensitivity ratio (Sr) of about 2600%, widespread reverse voltage regime (0∼ - 5 V), and stable hydrogen sensing current density–voltage (J–V) curves. The calculated Schottky barrier height change and series resistance variation from the thermionic emission model and Norde method are 87.0 meV and 288 Ω, respectively. The negative temperature dependence on Sr is due to the lower hydrogen coverage at higher temperature. Yet, the positive temperature dependence on Δ I is caused by thermal effect. Based on the excellent integration compatibility with InP-based electronic devices, the device studied does provide potential for high-performance sensor array applications.


Dextran sulfate enhanced immune response in mice immunized with sheep red blood cells. This stimulation took place only when dextran sulfate was given close to the time of antigen injection. Dextran sulfate injected one day prior or one hour after antigen inoculation was ineffective. The degree of stimulation of immune response by dextran sulfate depends on the polyanion doses and on antigen doses used. Maximum stimulation of immune response could be noticed when 500 μg dextran sulfate was injected one hour prior to inoculation of a suboptimal antigen dose, both dextran sulfate and 2 × 106 sheep red blood cells given via the same route intraperitoneally. However, significant stimulation of immune response also took place when dextran sulfate and antigen were given by different routes. Dextran has no effect on immune response, whereas DEAE‐dextran inhibits immune response in mice immunized with suboptimal antigen doses. Results obtained by these experiments clearly demonstrate that the polyanionic structure of polymers is a requirement for their adjuvant activity.


The general transcription factor IIH is recruited to the transcription preinitiation complex through an interaction between its p62/Tfb1 subunit and the α-subunit of the general transcription factor IIE (TFIIEα). We have determined that the acidic carboxyl terminus of TFIIEα (TFIIEα336–439) directly binds the amino-terminal PH domain of p62/Tfb1 with nanomolar affinity. NMR mapping and mutagenesis studies demonstrate that the TFIIEα binding site on p62/Tfb1 is identical to the binding site for the second transactivation domain of p53 (p53 TAD2). In addition, we demonstrate that TFIIEα336–439 is capable of competing with p53 for a common binding site on p62/Tfb1 and that TFIIEα336–439 and the diphosphorylated form (pS46/pT55) of p53 TAD2 have similar binding constants. NMR structural studies reveal that TFIIEα336–439 contains a small domain (residues 395–433) folded in a novel ββααα topology. NMR mapping studies demonstrate that two unstructured regions (residues 377–393 and residues 433–439) located on either side of the folded domain appear to be required for TFIIEα336–439 binding to p62/Tfb1 and that these two unstructured regions are held close to each other in three-dimensional space by the novel structured domain. We also demonstrate that, like p53, TFIIEα336–439 can activate transcription in vivo. These results point to an important interplay between the general transcription factor TFIIEα and the tumor suppressor protein p53 in regulating transcriptional activation that may be modulated by the phosphorylation status of p53.


Comparison between theoretical and observed speckle data at large telescopes allow a better accuracy in star diameters measurements by speckle interferometry techniques. Astrophisical results will be presented, based on observations from 3.6 meter ESO and CFH ( Canada-France-Hawaii) telescopes.


It is stated that inclusion of productive information as an input, output efficiency and product diversity play an important role in the development of countries.Economic complexity is described as an important concept that expresses the competence of countries in the context of sophisticated goods production. In the study described as E-7 countries Brazil, China, Indonesia, India, Mexico, Turkey and Russia panels using data from the 1993-2017 period, the panel cointegration analysis and causality analysis was performed.The study aims to investigate the relationship between economic complexity and human development concepts within the framework of the mentioned countries and the data range.For this purpose, Economic Complexity Index published by Atlas Media was used as an indicator of economic complexity and Human Development Index published by UNDP was used as an indicator of human development.When the long-term relationship between the two variables was analyzed by Westerlund Panel Cointegration test, it was observed that the cointegration relationship between economic complexity and human development variables was not found in E-7 countries.Then, in the study which carried out the Dumitrescu-Hurlin panel causality analysis, it was found that there was a one-way panel causality relationship from human development variable to economic complexity variable.


Ambulatory care is one of the fastest growing sections of the healthcare industry and yet little research has been done on challenges that can exist within preoperative care for ambulatory surgery. The research that does exist is typically only pilot studies. This paper will explore three overarching challenges that have appeared in preoperative care: Team performance, patient absences, and record errors. This paper will provide a description of these challenges and provide recommendations for further research.


The global business management shows leaning toward market orientation and became more challenging to the managers for resolving complex situations sprouting from the competition. Systems thinking has emerged as a tool to cope with the level of complexity in the markets by integrating the processes through logical frameworks. This article describes how systems thinking could provide a framework to various marketing process and create a map of the value chain that specifies relationships among the components of the marketing processes. The purpose of this article is to provide a conceptual framework of the development of systems thinking and systems methodologies and explain how such approaches can deal with issues of market complexity. This article proposes causal models of developing marketing strategy and develops insights on thinking as a method to achieve desired business performance.


Bud rot, a fatal disease of coconut caused by Phytophthora palmivora(Butl.) Butl. is increasing year after year in the high rainfall areas of coconut growing regions in India. An attempt has been made to evaluate some fungicides in inhibiting the growth of P.palmivoraunder in vitro condition by poisoned food technique as well as in inhibiting P.palmivora infection and lesion development on detached tender coconut leaflets by a new in planta assay technique. Out of 11 fungicides evaluated, Mixol (metalaxyl 8% + mancozeb 64%), Ridomil gold (metalaxyl M 4.0 % + mancozeb 64%), Sectin (fenamidone 10% + mancozeb 50%), Acrobat (dimethomorph 50%) and Curzate (cymoxanil 8% + mancozeb 64%) each at 250 ppm, Companion (carbendazim 12% + mancozeb 63%) at 500 ppm and Alliette (fosetyl-Al 80%) at 3000 ppm completely inhibited the growth of P.palmivora under in vitro condition as well as its infection on detached leaves. Among the fungicides tested on coconut leaves, Contaf (hexaconazole 5%) at 4000 ppm was the least effective in inhibiting P.palmivora infection. The new simple technique of in planta assay was thus found to be very promising in selecting the fungicides for field evaluation trials. Being a simple and very less expensive technique, it can also be used for large scale screening of germplasm collection against diseases as well as to test comparative virulence of different species/strains of the pathogen.