We recently identified polyglucosan body myopathy-2, a pure skeletal myopathic form of glycogen storage disease type XV, caused by glycogenin-1 deficiency, the priming enzyme of glycogen synthesis. To date 22 patients have been reported. They have juvenile to late-onset clinical symptoms with a variable distribution of muscle weakness. Muscle biopsies show the accumulation of polyglucosan bodies, consisting of hyper-intense periodic acid-Schiff (PAS)-positive material with a variable resistance to alpha-amylase treatment. Although cardiac involvement has been reported in 4 patients with glycogenin-1 gene (GYG1) mutations, these patients did not show any clear evidence of skeletal muscle disease. Here, we describe a 63-year-old woman born to consanguineous French parents, who developed right shoulder pain, difficulty climbing stairs and left foot weakness causing stumbling episodes at 46 years of age. Over time, the patient reported increasing difficulty elevating the right arm. At 61 years of age she also developed slight difficulty with left shoulder movement, and more recently she reported rare forearm fasciculations and nocturnal cramps in her thighs, calves, and toes. Physical examination at age 63 revealed right scapular winging increased by arm elevation, a waddling gait, and lumbar hyperlordosis. The antero-lateral compartment of both thighs was mildly atrophic. Manual muscle testing revealed marked weakness of right arm elevation and abduction. There was asymmetric deltoid weakness (Medical Research Council grade 3 on the right, 4 on the left) and milder symmetric lower limb-girdle weakness (4 to 41) in the gluteal, iliopsoas and hamstring muscles. Left ankle dorsiflexor strength was graded as 41. She also manifested abdominal muscle weakness, characterized by difficulty sitting from a supine position. There was no facial weakness. Serum creatine kinase levels were normal. Motor and sensory nerve conduction studies of the right and left peroneal and tibial, right median, and right ulnar nerves were normal as were 3 HZ repetitive stimulation studies of the spinal, peroneal and radial nerves. Needle electromyography revealed no abnormal spontaneous activity in trapezius, deltoid, extensor digitorum communis, vastus lateralis, and tibialis anterior muscles bilaterally. Motor unit potentials were of short duration and low amplitude, and demonstrated early recruitment. Electrocardiogram and cardiac ultrasound were normal. Muscle computed tomography scan of upper limbs revealed atrophy and fatty replacement of gluteal, vastus intermedius, vastus medialis, biceps femoris, and adductors muscles (Fig. 1A,B). Deltoid and infraspinatus muscles were also affected, predominantly on the right side (Fig. 1C). There was marked fatty replacement of lumbar and dorsal paraspinal muscles (Fig. 1D). Muscle biopsy of the left deltoid muscle revealed the presence of variable sized single or multiple vacuoles in approximately 10% of the muscle fibers. Vacuoles were located in the center or the periphery of cytoplasmic and subsarcolemmal areas. They contained hyperintense PAS-positive material (Fig. 2A) partially resistant to alphaamylase (diastase) digestion (Fig. 2B). Electron microscopy demonstrated the presence of polyglucosan bodies composed of poorly branched filamentous material organized in lobulated structures. A rim of normally structured granular glycogen and multiple mitochondria separated each lobule (not shown). Polyglucosan bodies were immunoreactive for desmin, P62, and TDP-43 (Fig. 2C). Muscle morphology findings prompted us to carry out Sanger sequencing of the GYG1 gene (NM_004130). The patient was found to harbor the previously reported homozygous single nucleotide substitution at the donor splice site in intron 2 (c.143 1 3G>C p.Asp3Glufs*4) leading to exon 2 skipping (r.8_143del) creating a frameshift p.Asp3Glufs*4. The c.143 1 3G>C variant is the most commonly identified mutation in polyglucosan body myopathy-2 patients, already reported in 25 alleles. Among the 11 homozygous patients with the c.143 1 3G>C mutation, 2 presented with onset in their teens and 9 had adult or late-onset Abbreviations: GYG1, glycogenin-1; PAS, periodic acid-Schiff base; PNPLA2, patatin like phospholipase domain containing 2; TDP-43, TAR RNA/DNA-binding protein


Shock capturing techniques for high-order methods have become a rich and intense area of research. However, significantly less attention has been paid to the effectiveness of capturing shock waves using high-order discretizations. This work examines the effectiveness of capturing shock waves using high-order discretizations from a robustness and error reduction point of view. Particular attention is paid to the most appropriate method of refinement for a shock wave. It is shown that when one considers exclusively shock capturing accuracy, mesh refinement employing a second-order discretization is significantly more effective at reducing error than order enrichment, despite the sub-cell shock wave resolution of high-order solutions. Furthermore, for flows involving shock waves in combination with smooth features, high-order discretizations are shown to be particularly effective when used as part of an hp-adaptation strategy. hp-adaptation is shown to yield superior efficiency compared with mesh refinement at second-order accuracy alone. To demonstrate the robustness of the proposed approach, hypersonic (M¥ 6:0) applications are considered exclusively. It is demonstrated that hp-adaptation combined with PDE-based artificial viscosity is capable of robustly obtaining low discretization error with accurate and smooth surface heating profiles.


Uniform Content Locator (UCL) technology builds a bridge among writers, editors and readers for better understanding, which is a foundation for data processing such as receiving quickly, serving intelligently and actively. Besides introducing the concept of UCL, its key technologies are also discussed. Based on the content comprehension of network information, the describable system for information resource is established. After that, the method of automatic information indexing and the mechanism of active services for network based on UCL are brought forward, which can provide users active services intelligently and personally.


Few studies have addressed the sociodemographic characteristics and risk of wound development in northeastern Brazil. The objective of the study was to determine the prevalence of wound risk and the related factors in people with diabetes in the municipality of Parnaíba, Piauí State, Brazil. A cross-sectional study was conducted with 300 people with diabetes. The volunteers were assessed using a sociodemographic questionnaire, a 10 g monofilament, a 128 Hz tuning fork, a reflex hammer, and a wound risk rating scale. Male sex (OR 2.33, 95% CI 1.22-4.42), age (OR 1.03, 95% CI 1.01-1.05), physical inactivity (OR 2.35, 95% CI 1.26-4.38), and a longer duration of diabetes (OR 3.28, 95% CI 1.56-6.91) were associated with wound risk. This study demonstrated a high wound risk related to age, male sex, duration of diabetes, and physical inactivity and a high prevalence of complications such as diabetic peripheral neuropathy and amputations.


This report discusses the testing and evaluation of four commercially available fiber optic intrusion detection systems. The systems were tested under carpet-type matting and in a vaulted ceiling application. This report will focus on nuisance alarm data and intrusion detection results. Tests were conducted in a mobile office building and in a bunker.


In a network, a <inline-formula><tex-math notation="LaTeX">$k$</tex-math><alternatives><mml:math><mml:mi>k</mml:mi></mml:math><inline-graphic xlink:href="grbic-ieq2-2898189.gif"/></alternatives></inline-formula>-plex represents a subset of <inline-formula><tex-math notation="LaTeX">$n$</tex-math><alternatives><mml:math><mml:mi>n</mml:mi></mml:math><inline-graphic xlink:href="grbic-ieq3-2898189.gif"/></alternatives></inline-formula> vertices where the degree of each vertex in the subnetwork induced by this subset is at least <inline-formula><tex-math notation="LaTeX">$n-k$</tex-math><alternatives><mml:math><mml:mrow><mml:mi>n</mml:mi><mml:mo>-</mml:mo><mml:mi>k</mml:mi></mml:mrow></mml:math><inline-graphic xlink:href="grbic-ieq4-2898189.gif"/></alternatives></inline-formula>. The maximum edge-weight <inline-formula><tex-math notation="LaTeX">$k$</tex-math><alternatives><mml:math><mml:mi>k</mml:mi></mml:math><inline-graphic xlink:href="grbic-ieq5-2898189.gif"/></alternatives></inline-formula>-plex partitioning problem is to find the <inline-formula><tex-math notation="LaTeX">$k$</tex-math><alternatives><mml:math><mml:mi>k</mml:mi></mml:math><inline-graphic xlink:href="grbic-ieq6-2898189.gif"/></alternatives></inline-formula>-plex partitioning in edge-weighted network, such that the sum of edge weights is maximal. The Max-EkPP has an important role in discovering new information in large biological networks. We propose a variable neighborhood search (VNS) algorithm for solving Max-EkPP. The VNS implements a local search based on the 1-swap first improvement strategy and the objective function that takes into account the degree of every vertex in each partition. The objective function favors feasible solutions and enables a gradual increase of the function's value, when moving from slightly infeasible to barely feasible solutions. Experimental computation is performed on real metabolic networks and other benchmark instances from the literature. Comparing to the previously proposed integer linear programming (ILP), VNS succeeds to find all known optimal solutions. For all other instances, the VNS either reaches previous best known solution or improves it. The proposed VNS is also tested on a large-scale dataset not considered up to now.


The objective of this paper is to develop variable sampling interval multivariate control charts that can offer significant performance improvements compared to standard fixed sampling rate multivariate control charts. Most research on multivariate control charts has concentrated on the problem of monitoring the process mean, but here we consider the problem of simultaneously monitoring both the mean and variability of the process.


Background: Mannose-binding lectin (MBL) is a component of innate immunity and particularly important in neonates in whom adaptive immunity is not yet completely developed. MBL deficiency and MBL is associated with an opsonization defect and have been associated with recurrent infections. Objectives: The aim of our study was to determine whether serum MBL levels could serve as markers for predicting neonatal sepsis in neonatal intensive care (NICU). Patients and Methods: This case- control study was conducted on 75 neonates classified into 3 groups: The first group (septic) included 30 neonates who had clinical and laboratory signs of neonatal sepsis..  The second group (suspected) included 30 neonates who had clinical not laboratory signs of neonatal sepsis. The third group (control) included 15 healthy neonates who had no clinical nor laboratory signs of neonatal sepsis ELISA technique was used for measuring MBL serum concentration. Results: Serum MBL levels were significantly lower in the neonates with sepsis or suspected than in the control group. MBL had high sensitivity and specificity values to detect sepsis. Conclusion: MBL serum level could be considered a sensitive and specific marker for prediction of neonatal sepsis. Neonates with significant decrease in MBL are at increased risk for developing sepsis and septic shock.


This paper is an attempt at presenting a high level model of the set and graph aspects of the graph algorithmic language GRAAL [5]. The problem area for which the language GRAAL was designed was the solution of graph problems of the type primarily arising in applications. It was designed with two objectives in mind. The first was to develop a language which permitted the writing of graph algorithms in a highly readable form with as natural a set of primitives as possible for describing the algorithm. The second was to allow for a wide variety of graphs of different types and complexity with as little degradation as possible in the efficient implementation and execution of an algorithm designed for a specific type of problem.


Patient specific (PS) blood flow studies have become popular in recent years but have thus far had limited clinical impact. This is possibly due to uncertainties and errors in the underlying models and simulations set-up. This study focuses on the sensitivity of simulation results due to in- and outflow boundary conditions (BC:s). Nine different inlet- and seven different outlet BC:s were applied to two variants of a healthy subject's thoracic aorta. Temporal development of the flow is essential for the formation and development of helical/spiralling flow where the commonly observed clockwise helical motion may change direction during the heart-cycle. The sensitivity to temporal and spatial variations in the inlet conditions is significant both when expressed in terms of mean and maximal wall shear stress (WSS) and its different averaged variables, e.g. Time-Averaged WSS (TAWSS), Oscillating Shear Index (OSI) and Relative Residence Time (RRT). The simulation results are highly sensitive to BC. For example, the maximal WSS the results may vary over 3 orders of magnitude (1 to 1000 Pa) depending on particular combinations of BC:s. Moreover, certain formulations of outlet boundary conditions may be inconsistent of the computed flow field if the underlying assumptions of the space-time dependence are violated. The results of this study show that CFD simulations can reveal flow details that can enhance understanding of blood flows. However, the results also demonstrate the potential difficulties in mimicking blood flow in clinical situations.


Under the Crown, the unifying principle of our constitution is the common law. The common law's distinctive method has endowed the British state with profoundly beneficial effects. In this Lecture I will explain why this is so. I will say that by force of the common law, efficacy is allowed but oppression is forbidden to the power of the state; and this is achieved by a benign continuum of developing law. I will tell what is a constitution's unifying principle, and what is the distinctive method of our constitution's unifying principle, the common law. I will give two instances of changes wrought without revolution by the common law's processes; the first concerns the sovereignty of Parliament, the second the judicial review jurisdiction. Then I will explain how Parliament's legislation only has effect through the methods of the common law. The common law is the interpreter of our statutes, and is the crucible which gives them life. The process of interpretation is intensely coloured by the common law's insights of substantive principle: reason, fairness and the presumption of liberty. So is the judicial review of executive action. The result is that statute law and government policy are alike delivered to the people through the prism of such principles. This is the gift of the common law, the unifying principle of our constitution. It is the means by which legislature and government are allowed efficacy but forbidden oppression.


This article takes as its starting point a quotation from the British East Asian actor Paul Courtenay Hyu concerning casting practice at the Royal Shakespeare Company (RSC): 'They have an all-black Julius Caesar and an all-Indian Much Ado, but when they decide to do the Chinese Hamlet, they cast fourteen out of seventeen actors and all of the major parts as non-Chinese. In the 21st century, that's unbelievable.' Hyu raises many issues including diversity policies, politics of ethnic minority casting, and cultural representation, all of which were contested following the casting choices made by the RSC in 2012. I use the American scholar Ayanna Thompson's theories concerning 'non-traditional' casting policies as a lens through which to analyse contemporary British theatrical practices. The concepts of 'colour-blind' and 'cross-cultural' casting are examined in the context of the World Shakespeare Festival where the ethos of celebrating Britain's 'unique internationalism' and diversity was championed. As the Olympic year drew to a close, there were clear tensions between celebration and condemnation, expectation and disappointment, visibility and invisibility, regarding the representation of performers from ethnic minority backgrounds appearing on stage at the RSC. Through an examination of Much Ado About Nothing directed by Iqbal Khan, and Julius Caesar and The Orphan of Zhao, both directed by Gregory Doran, this article seeks to address the complexities involved in different approaches to casting, and the impact these evolving practices have on the cultural representation of diverse communities in contemporary Britain.


Abstract Using the RF cathode sputtering method, ferroelectric films of barium-strontium niobate Sr0.5Ba0.5Nb2O6 were synthesized on a semiconductor substrate. Their phase composition, crystal structure, nanostructure, dielectric, and ferroelectric characteristics were studied. The temperature ranges of phase transformations, the characteristic values of spontaneous polarization and coercive fields, the magnitude and nature of the change in the imaginary and real parts of the complex permittivity in the temperature range −190 ÷ 250 °C were established in the films. The reasons for the revealed regularities are discussed.


Summary 1.The surface tensions of cancer and noncancer sera were determined in progressive dilutions with 5 per cent acetamide. 2.The difference between the initial and minimum surface tension values was found to be positive in pregnancy and most of the cancer samples, whereas it was negative in most of the other samples. 3.A conventional unit, the critical area, was defined and found to be positive in pregnant and most of the cancerous samples, whereas it was negative or slightly positive only in other samples. 4.The modified MR is discussed from the point of view of the combination theory.


The issues of plagiarism have been mushrooming more rapidly around the globe. India is also not spared from plagiarism and related issues. Various researchers and academicians have raised their concern on rapidly growing cases of plagiarism. In this study, an analysis was made to identify the average growth of publications written on plagiarism by Indian authors, the degree of author collaboration, most impactful sources for publishing on plagiarism. The data for the period of 2002 – 2016 were extracted from Scopus by executing a query on 'Plagiarism' term. In total 385 publications were found and computed. Average citations per publications of 4.01 for the period, 2007-11 was found high as compared to two other block periods of the study whereas block period 2002-06 was witnessed 49.53 per cent annual growth rate. The Single authored publications prevailed more (34.55 per cent) which interestingly also achieved 50.38 per cent of the cited rate. It was also observed that the degree of multi-authored collaboration has been improving with every passing year.


Abstract. In this note we give an alternate expression of class number formulafor real quadratic elds with discriminant d 5 mod 8. 1. IntroductionLet pbe an odd prime with p1 mod (4) and "be the fundamental unit of Q(pp).It is well known that the class number hin this case is given byh=pp2log"L(p)where L(p) =P 1k=1p k 1 . From here one can deduce classical Dirichlet's classnumber formula" 2h =Q n (1 n )Q v (1 v)where is the primitive p-th root of unity; vand nrun over the quadratic residues andnon-residues of prespectively in the interval (0;p). This formula exhibit class numberhof the corresponding real quadratic eld in a \transcendental" manner. A somewhatsimpler formula was proved by P. Chowla [3] in the case of prime discriminant of theform p5 mod 8. She took the square root of the above classical formula to deriveher formula.We derive an alternate class number formula for real quadratic elds with discrim-inant d5 mod 8. We appeal to another form of the class number formula for "


The article brings to light the relationship between politics and social sciences in interwar Poland in its local and transnational dimensions. It explores the beginnings of expertise in ethnology and the evolution of the discipline's tools and methods as closely linked to the political goals of the interwar Polish state, and the post-coup Sanacja [Sanation] regime in particular. Ethnologists carried out fi eldwork focused on multiethnic territories, such as Eastern Galicia, which were subjected to international territorial disputes. The collaboration with politicians and the administration – developed mostly in the framework of research institutes – was a source of inspiration and, at the same time, stiff competition between scienti fi c schools. To illustrate some consequences of this collaboration, the article traces an argument over scienti fi c approaches to the 'ethnic question' which involved ethnologists and empirical sociologists, and the connection of this argument to the objectivity principle in science. These different approaches re fl ect international theoretical and epistemological divisions at the time as much as they show the direct and indirect exchange of ideas within the European scholarship.


In current systems, patients' data and information that are critical are scattered across different systems and institutions. Due to this, non-trivial data is not handily available or accessible when needed. Such problems related to patient healthcare data can be handled effectively using blockchain solutions. This ever-increasing data leads to problems in managing patient information within clinics and hospitals. Our project aims to create a hash for individual patient health information blocks. It would also permit patients to keep their identity secret and reveal the necessary information to third parties at the same time. The access permissions and time limit for data sharing can also be controlled by them. A platform called "Ethereum" will be used as the blockchain technology to create an application that will store patients' data securely in the blockchain. A contract-based language called "Solidity" will be used to bind each patient' data with their unique addresses to the blockchain and to provide functionalities to the application. A browser-based user-interface will be developed to be used by the users that will connect with the blockchain internally.


Objective To explore effects of blood osmotic pressure in neonatal diseases.Methods 96 hospitalized newborns were randomly selected for detecting blood osmotic pressure.There were 36 newborns with neonatal pheumonia,21 newborns with neonatal jaundice,24 newborns with asphyxia of newborn,and 15 newborns with neonatal cold injure syndrome.20 normal newborns were detected blood osmotic pressure as control.Result Blood osmotic pressure of newborns with neonatal pheumonia,neonatal jaundice, asphyxia,cold injure syndrome,and control were 261.0±1.5 mOsm/L,270.5±2.0 mOsm/L,252.2±3.8 mOsm/L,258.0±3.2 mOsm/L,and 288.6±17.5 mOsm/L, respetively.The blood osmotic pressure of newborns with diseases was significant difference from that of control(P0.05).Conclusion Blood osmotic pressure of newborn with diseases is lower than that of normal newborns,which suggests that blood osmotic pressure can show the pathogenetic condition.


This means for the absorption of torsional vibrations is suitable for an internal combustion engine, in particular a passenger car, and that said device is active between the internal combustion engine and a transmission. In order to optimize the device with regard to simple construction and low construction cost, a working between the internal combustion engine and the transmission input shaft and is in operative connection with the input shaft drive shaft of the transmission are respectively formed as a relatively twistable torsion bar springs, where both the input shaft as well as to the drive shaft rotating mass devices are provided.


The CAD of a Tchebyscheff tapered balun transformer which will function over frequency bandwidths as great as 100:1 is presented. The balun impedance is tapered so that the input reflection coefficient follows a Tchebyscheff response in the pass band. But some functions in the theory are not expressible in closed form except for special values of the parameters. So the values of the functions are obtained from the tabulation. As a result, the design of the balun can not get more accurate values of the functions. With the numerical calculation, we can get the exactly values in a few seconds.


Consolidation of soft sediments stored in the confined disposal facilities or mine tailing dams has challenged the scientists to come up with the best consolidation device for the past 50 years. Since the Terzaghi consolidation theory does not apply in soft sediments due to lack of permeability measurements and self-weight effect, the seepage-induced consolidation seems to be the best tool for soft sediments consolidation determination. Besides, index properties are easily obtained in any soil's laboratory and can be fast and accurate. Therefore, correlation of consolidation with index properties can help disposal facility designers to have a better perspective on the consolidation of similar sediments. This paper presents the result of seepage-induced consolidation test on six different soft soils and correlates their index properties with seepage-induced consolidation model. Finally, the correlation results are compared with the test data and similar correlations in the literature. The proposed correlation shows very satisfactory predictions to the laboratory test results.


Applying the same LANDSAT-1 data to three substantially different image processing systems, a snow mapping task was performed. LARSYS Ver.3, STANSORT-2, and General Electric Image-100 did all the jobs of detecting the snowline in forested mountainous terrain, and to determine the snowcovered area. While the control and accuracy achieved with LARSYS is remarkable, time and effort to perform the processing favor the systems STANSORT and Image-100. The experiences and results demonstrate the need for a fast interactive system for operational snowmapping with multispectral satellite data.


Alcohol and Other Drug (AOD) presentations are common in the Emergency Department (ED) especially on weekends (Parkinson et al. 2016) and the presence of AOD use can account for substantial healthcare costs (Butler et al. 2016).


Plasma renin activity (PRA) and aldosterone (Aldo) levels are high in the newborn. The purpose of this study was to determine the effects of labor and delivery on PRA and Aldo in the newborn; and to determine how PRA and Aldo levels change during the early newborn period. 28 fullterm and 6 preterm infants, 32-36 weeks gestation, were studied at ½, 2, 4, 24 and 48 hrs. All were born after an uncomplicated vaginal delivery (VAG-D) with apgar scores >7 at 5 min. PRA and Aldo were measured by RIA. The Mean and SEM (ng/ml/hr) PRA in umbilical vein (UV) plasma was 16.2 ± 5.1 after C-Sec alone, N=6; 44.1 ± 8.9 after C-Sec in labor. N=16 p<.05; and 34.7 ± 4.3 after VAG-D, N=28, p<.05. The latter two groups did not differ. There were no differences in UV vs VA PRA or Aldo levels. The UV PRA level in preclampsia (52.6±5.0) was higher than in normal VAG-D (p<.05). Serial PRA values in full term infants decreased from 34.7 ± 4.3 in UV plasma to 18.3 ± 4.4 at 2 hrs (p<0.05), and were statistically similar (30.7 ± 4.4) at 24 hours. Aldo levels also remained unchanged. UV PRA and Aldo levels after VAG-D and during the subsequent 48 hrs of life were similar in the preterm and fullterm infants.Conclusions: a) Labor increases PRA levels in fullterm and preterm infants. b) Preclampsia is associated with high PRA cord blood levels. c) PRA and Aldo levels do not fall during the early newborn period, suggesting continual stimulation after delivery.


Summary. There appears to be a direct relationship between complement consumption in the rabbit (demonstrated by a fall in CH50 and plasma C3 concentration) and the temporary disappearance of platelets and neutrophils from the circulation during IgM cold antibody induced intravascular haemolysis. Studies with 51Cr‐labelled platelets showed that although the platelet counts returned to initial values following the thrombocytopenia, 18–38% of the labelled platelets failed to return, suggesting platelet loss at the site of sequestration (mainly the lungs) and dilution of the recirculating platelets with unlabelled platelets from another pool. There is no evidence that these events trigger intravascular coagulation. Complement‐depleted rabbits are totally refractory to further attempts to produce lysis, thrombocytopenia and neutropenia by cold antibody, though, even when complement activity in the plasma is allowed to recover, the lytic response to doses of cold antibody similar to those originally given, is reduced. The surviving circulating red cells are coated with C3 following an acute lytic episode and the immune‐adherence of neutrophils and platelets to fixed‐C3 on red‐cell membranes in the pulmonary circulation provides one possible mechanism for the thrombocytopenia and neutropenia.


The aim of this study is to analyse durational patterns and functions of disfluent whole-word repetitions in diverse age groups and speech tasks. Speech samples of school children (9-year-olds), adolescents (13-14-year- olds), young adults (20-25-year-olds) and old speakers (75+) were selected for the analysis. Recordings were made with each subject in two situations representing different speech tasks: 1) spontaneous narrative (participants spoke about their own lives and families), and 2) narrative recall (the task was to recall two texts they had listened to as accurately as possible). Results show that there are differences in the durational patterns and functions between the age groups in both speech tasks. Editing phases were significantly longer in 9-year-olds than in adults. In the ratio of the duration of R2 and R1, there were significant differences between 9-year-olds and the other three age groups, and between adolescents and the old speakers. As regards functions, in spontaneous narratives, the ratio of canonical repetitions was higher in 13- and 20-30-year-olds, and the ratio of stalling repetitions was higher in 9- and 75+-year-olds. In narrative recall, the ratio of stalling repetitions rose in 20-30- and 75+-year-olds. However, there were no significant differences between the speech tasks in any age group.


The composition of polyphenolic compounds in various parts of the
Rosebay willowherb (Chamerion angustifolium) has been studied in detail and published. A
number of these compounds have sufficient antiradical activity (ARA) to create functional foods
based on extracts from this plant that are preventive against free-radical pathologies in humans.
Part of substances with antiradical activity (e.g., vitamins, polyphenol components) are destroyed
during the technological processing of food raw materials, and the values of ARA drop in the finished food product concerning the initial values (before and after technical processing) are not
fully evaluated.

The composition of polyphenolic compounds in various parts of the Rosebay willowherb (Chamerion angustifolium) has been studied in detail and published. A number of these compounds have sufficient antiradical activity (ARA) to create functional foods based on extracts from this plant that are preventive against free-radical pathologies in humans. Part of substances with antiradical activity (e.g., vitamins, polyphenol components) are destroyed during the technological processing of food raw materials, and the values of ARA drop in the finished food product concerning the initial values (before and after technical processing) are not fully evaluated.

The object of the study is to study the thermal stability of polyphenol components
possessing ARA (dried at 60°C and 150°C) and evaluate their residual ARA in the finished food
products, N-acetylcysteine (NAC), as one of the known antiradical, was used as a reference substance.

The object of the study is to study the thermal stability of polyphenol components (Chamerion angustifolium) possessing APA (dried at 60°C and 150°C) and evaluate their residual APA in the finished food products, N-acetylcysteine (NAC), as one of the known antiradical, was used as a reference substance.

Spectrophotometric method was used to evaluate the change of ARA in prepared
foods. Gas chromatography-mass spectrometry (GC-MS) was used as an additional method to
evaluate the difference in the chemical composition of polyphenol components.

Spectrophotometric method was used to evaluate the change of APA in prepared foods. Gas chromatography-mass spectrometry (GC-MS) was used as an additional method to evaluate the difference in the chemical composition of polyphenol components (Chamerion angustifolium).

The residual ARA in the finished products (for caramel and bakery products) was ≈
23.9% for rapidly extractable substances, for polyphenol compounds ≈ 46.1%, and for amino acids and easily hydrolyzable substances ≈ 34.5%.

The residual APA in the finished products (for caramel and bakery products) was ≈ 23.9% for rapidly extractable substances, for polyphenol compounds ≈ 46.1%, and for amino acids and easily hydrolyzable substances ≈ 34.5%.

Rosebay willowherb extract and N-acetylcysteine are recommended for increasing
the ARA (between 1.6 – 4.9 times) of foods with low ARA (confectionery, bread, or other heavily processed foods) and for diets and diets preventive of free-radical pathologies by adding polyphenolic plant components and cysteine derivatives.

Rosebay willowherb extract (Chamerion angustifolium) and N-acetylcysteine are recommended for increasing the APA (between 1.6 – 4.9 times) of foods with low APA (confectionery, bread, or other heavily processed foods) and for diets and diets preventive of free-radical pathologies by adding polyphenolic plant components and cysteine derivatives.

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The mouth agape is among humankind's most prevalent motifs, its imagery appearing across cultures, continents, and centuries, the significations of which hold all the grand preoccupations of the human experience: terror, hunger, and awe. Accepting Mikhail Bakhtin's estimation that the mouth is "the most important of all human features for the grotesque," this article examines the disparities between different renderings of these ontological black holes and their disparate implications in horror and g/Gothic texts. While the Scream visualizes terror's sonic expression, this article introduces it alongside what I call the Swallowing: the occasion where the object of fear (the monster) takes the form of a devouring other. A challenge to essentialist interpretations of Julia Kristeva's concept of abjection, analysis of the Swallowing lends support to Jack Halberstam's estimation of monsters and g/Gothic horror as narrative and cultural technologies. This article will therefore employ Jeffrey Jerome Cohen's method of "reading cultures by the monsters they engender." If we explore the Swallowing as it appears in both Black horror and Black-led horror films, what might be revealed about the ways b/Blackness has been rendered monstrous within the ideological lexicon of the white imagination? How does Black horror challenge these renderings? And further, what power might we identify in embracing monstrosity as a condition of being?


In history he will absolve me, the then young lawyer Fidel Castro Ruz denounced the evils of Cuba at that time, among them those concerning the health of the people. Since the armed struggle against tyranny, the doctors of the Rebel Army attended to the peasants in the mountainous and remote places. From the Triumph of the Revolution, in 1959, to fulfill the Moncada Program, actions began to transform the health sector into the well-being of the people. The thought of the historical leader was promoter of changes in health, which reached universal dimensions. The objective of this work is to carry out a logical historical analysis of the importance of Fidel's thought and work for the historical development of health professional training and the main achievements of Cuban medicine. A literature review was performed, the theoretical-historical-logical method was used. Fidel's ideas have contributed to the development of medical care, teaching and research, and influenced programs aimed at primary and specialized care, which consolidated the National Health System. Inspired by its legacy, its solidarity and humanistic values, medical collaboration has extended too many countries. His thinking, in force as a revolutionary doctrine, proclaims that a world governed by values for the good of the citizen is possible, necessary and cannot be postponed. His ideology and work in health is a perennial reference for students and professionals in Cuba and other countries, because it constitutes the political and ideological foundation of the principles of Public Health in Cuba.


The state-of-the-art LZ77 compression replaces repeated occurrences of a string with references to a single copy of that string existing earlier in the uncompressed string stream. A match is encoded by a pair of numbers called a length-distance pair. To spot matches, the compressor must keep track of some amount of the most recent string, such as the last 4KB, 8KB, or 32KB. The structure in which this string is held is called a sliding window. In practice, searching for the longest string match is expedited by a hash table and a hash chain (it simply uses a hash table when only the first match is considered). In this paper, we present a novel technique to effectively improve the LZ77 compression. Specifically, it applies different sliding windows for each match length, each possibly equipped with different hashing functions. It effectively thwarts the dilemma of the original single-window, wherein a large window size renders short strings incompressible (e.g., a 2-byte match in a 16-bit window) whereas a small window size renders long strings (lying outside of window) incompressible.


Introduction: Adults age ≥65y constitute the majority of patients (pts) diagnosed with cancer. There is a gap in knowledge about the safest and most effect cancer treatments for older pts. At The Ohio State University, we have a longitudinal multidisciplinary geriatric clinic for adults ≥ 65 years of age diagnosed with breast cancer (BC). The clinic team consists of a physician, nurse practitioner, dietician, physical therapist, social worker nurse, and pharmacist. We evaluate the unique needs of older pts with breast cancer by completing a comprehensive geriatric assessment (CGA). Eligible patients are enrolled into OSU-16153 which is a is prospective cohort study of pts ≥65y with new diagnosis of BC to better understand complex health issues of this population, and to collect data to support future studies. Methods: Forty eight pts have completed the baseline questionnaires including demographics, lifestyle and health history and CGA. Summary statistics were used to describe the baseline characteristics. Results: The median age of patients enrolled in the study was 77 years (range 67-94), the mean BMI was 28, 50% (24/48) were Caucasian and 6% (3/48) were African American. Mobility was assessed mobility with the time get up and go (TGUG), mean 9.8 (SD=6.2) and grip strength, mean of 31. Cognitive limitations were screened with the blessed orientation memory concentration test, mean 3.9 (SD=5.0) and mini-cog, mean 3.6 (SD=1), malnutrition, mean 12.3 (SD=12.2) and depression, mean 1.6 (SD=2.4). Functional limitations were measured with Katz, mean 5.9 (SD=0.2), and Lawson, mean 7.8 (SD=0.8). Disease characteristics included 18% (9/48) Tis, 54% (26/48) T1, 21% (10/48) T2, 2%(1/48) T3, and 4% (2/48) T4 tumors, 65% (31/48) lymph node negative and 81% (39/48) estrogen positive (ER+),17% (8/48) ER negative and 4% (2/48) HER2 positive. Oncotype score was 25 in 4% (2/48). Twelve percent (6/48) received adjuvant chemotherapy for triple negative or ER+ breast cancer with high oncotype with docetaxel/cytoxan and 4% received trastuzumab based therapy and they were able to complete all planned cycles. Two pts received chemotherapy based on results of CGA. Forty-two pts were eligible to receive endocrine therapy (ET); 3 pts with ductal carcinoma in-situ (DCIS) and 2 pts with invasive BC declined, 1 did not follow up after her initial visit. Five pts switched ET due to side effects. The 7 patients with invasive BC who declined or switched ET due to side effects all had an abnormal TGUG, 43% (3/7) had an impaired min-cog and 57% (4/7) had impaired hand grip. Conclusions: The majority of older adults have no functional deficits in ADL/IADL, have adequate mobility and grip strength and did not screen positive for cognitive limitations, depression or, malnutrition. Our data shows that the mobility and cognitive assessment of a CGA may serve as a predictor of toxicity from ET therapy and identify patients who are at risk for side effects and who may benefit from additional interventions. The majority of pts who received adjuvant chemotherapy and ET tolerated well. Our pilot data shows a CGA is feasible and that a CGA helped direct appropriate therapy. Citation Format: Nicole Williams, Julie Stephens, Elizabeth Kress, Erin Frey, Susan Fugett, Paige Erdeljac, Stephanie Yager, Erin Holley, Cari Utendorf, Nikki Ford, Caitln Ubbing, Jeanie Overcash, Bhuvaneswari Ramaswamy, Anne Noonan. Feasibility of comprehensive geriatric assessment in an academic breast oncology clinic [abstract]. In: Proceedings of the 2019 San Antonio Breast Cancer Symposium; 2019 Dec 10-14; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2020;80(4 Suppl):Abstract nr P4-16-01.


Virtual experiment system is a remote teaching environment. With the development of computer and virtual reality technology, it is imperative in the experiment teaching of courses. Based on the analysis of experiment prototype and virtual technology, it builds the infrastructure of a Web-based experiment system, discusses the related techniques and virtual reality technology, presents the integration of Web technology and database. A system for automatic product lines is developed.


The lateral surface of a cylindrical structure, which is composed of a thin tube embedded in a large outer medium, is submitted to a uniform external pressure. The buckling pressure of such a structure, corresponding to a low flexural state of the inner tube wall, is theoretically analyzed on the basis of the asymptotic method, The theoretical results are compared with experimental ones obtained from a compression test realized on an elastic tube inserted in a foam. It is found that the Euler pressure and the associated buckling mode index strongly depend upon the rheological and geometrical parameters of both the tube and the surrounding medium.


Novel (R)-(+)-1,1-bi-2-naphthol ((R)-(+)-BINOL)-based conjugated microporous polymers (CMP1-4) with high Brunauer-Emmett-Teller (BET) surface area are synthesized through Sonogashira-Hagihara cross-coupling of di-/tetra-bromo-substituted (R)-(+)-BINOL derivatives and 1,3,5-triethynylbenzene. Fluorescence studies find that CMP4 can act as a sensitive and enantioselective sensor for chiral amino alcohols, such as 2-amino-1-propanol (AA1), 2-amino-3-methyl-1-butanol (AA2), and 2-amino-2-phenylethanol (AA3), which expands the application scope of conjugated microporous polymers.


We explore the influence of the deformation on the nuclear matrix elements of the neutrinoless double beta decay (NME), concluding that the difference in deformation -or more generally in the amount of quadrupole correlations- between parent and grand daughter nuclei quenches strongly the decay. We correlate these differences with the seniority structure of the nuclear wave functions. In this context, we examine the present discrepancies between the NME's obtained in the framework of the Interacting Shell Model and the Quasiparticle RPA. In our view, part of the discrepancy can be due to the limitations of the spherical QRPA in treating nuclei which have strong quadrupole correlations. We surmise that the NME's in a basis of generalized seniority are approximately model independent, i. e. they are "universal". We discuss as well how varies the nuclear matrix element of the 76Ge decay when the wave functions of the two nuclei involved in the transition are constrained to reproduce the experimental occupancies. In the Interacting Shell Model description the value of the NME is enhanced about 15% compared to previous calculations, whereas in the QRPA the NME's are reduced by 20%-30%. This diminishes the discrepancies between both approaches. In addition, we update the effects of the short range correlations on the NME's in the light of the recently proposed parametrizations obtained by renormalizing the 0νββ transition operator at the same footing than the effective interaction.


Objective
To evaluate the clinical efficacy of laparoscopic fenestration drainage combined with dehydrated alcohol perfusion and bipolar electro-cauterization of cyst wall in treating hepatic cyst.

Methods
Clinical data of 15 patients with hepatic cyst undergoing laparoscopic fenestration drainage combined with dehydrated alcohol perfusion and bipolar electro-cauterization of cyst wall in the First People's Hospital of Foshan between January 2013 and December 2015 were retrospectively analyzed. Among them, 7 patients were male and 8 were female, aged 40-65 years with a median age of 51 years. The informed consents of all patients were obtained and the local ethical committee approval was received. All the patients received laparoscopic fenestration drainage, dehydrated alcohol perfusion and bipolar electro-cauterization of cyst wall. Intraoperative and postoperative physical conditions of the patients were observed.

Results
The surgery was successfully completed in all patients. No conversion to open surgery occured. The median operating time was 60(50-75) min. The intraoperative hemorrhage volume was 30(15-50) ml. The volume of drainage cystic fluid was 1 450(1 000-2 000) ml. The postoperative time of removal of drainage tube was 3(2-4) d. The postoperative length of hospital stay was 4(3-5) d. Neither bile leakage nor hemorrhage complications occurred after surgery. No recurrence was observed in all patients by ultrasound, CT scan or MRI 1 year after surgery.

Conclusions
Laparoscopic fenestration drainage combined with dehydrated alcohol perfusion and bipolar electro-cauterization of cyst wall is a safe and effective way for treating hepatic cyst. It has the advantages of minimally invasion, low incidence of bile leakage and recurrence rate.

Key words:
Drainage; Ethanol; Bipolar electrotome; Hepatic cyst


The urban environment imposes severe stress upon vegetation. The problems are many, and interactions common, making simple solutions difficult. This paper on urban soils discusses basic soil physics and soil chemistry, reviews some existing literature, and describes several research efforts in Washington. Particular emphasis is placed on soil compaction and ways to minimize its deleterious effects upon vegetation. This year is the 200th birthday of the United States and estimates of visitation to the Washington metropolitan area range between 15- 60 million. Most of these visitors will presumably descend upon Washington between Memorial Day and Labor Day. Naturally National Capital Parks, National Park Service is aware of the extreme impact this number of visitors will have upon our urban parks and are taking some steps to minimize this impact. At present, National Capital Parks has jurisdictional and management responsibilities for nearly 23% of the land area within the District of Columbia's boundaries, including all of the National Monuments from the White House down through the lesser important monuments.


This study took Jubeat as an example to explore players' motivation and continual playing behavior. In addition, the differences between players with different backgrounds to start playing this kind of music game were also investigated. According to the literature review and the questionnaire survey, arcade games equipped with special controllers and fantastic acousto-optic effects plays an important role in attracting players. When it comes to continuing the game, there are five factors: Combination of hobbies, Challenge and skill, Fantasy, Emotion and Social interaction that impact them, with the former two as the most pivotal elements. That is, games that allow players to enjoy their favorite songs and challenge themselves at the same time are most attractive. These five factors affect players with different ages, genders, and addictions to the game differently. Among them, "Social Interaction" is shown to have the greatest influence upon those who are greatly addicted to the game.


AIM: To introduce the indicators Clarc of energy distribution (CED) and Clarc of protein/amino acid transformation (CPT) and adapt the methodology for their calculation in aquaculture. MATERIAL AND METHODS: A 50-day experiment was carried out with juvenile carp fish (C. carpio L.) reared in net cages. The following characteristics were reported: fodder (nutritional) coefficient, digestible energy, and crude protein intake per unit of weight gain, percentage of the boneless fillet, the chemical composition of the fillet. The methodology for calculating the respective Clarcs was described. RESULTS: The following values of the newly introduced indicators were established: Clarc of energy distribution (CED) – 0.0866 (8.66%); Clarc of protein transformation (CPT) – 0.1052 (10.52%).


Building on their experiences with social media and collaborative learning, the authors have proposed the development of an Integrated Learning Ecosytem called Scholr. Scholr is a comprehensive, integrated software environment that supports the development, delivery, assessment, and administration of educational courses, in addition to providing a modifiable toolset that can be used to foster collaborative forms of blended learning within the classroom and online delivery of course content. Scholr allows technology to play a more active role in supporting learning, both inside and outside of the classroom. This paper discusses the collaborative learning projects that inspired the proposal, setting the context for and outlining the key features.


This paper presents an overview of state-of-the-art acoustic isolation in MEMS and compares several acoustic isolation techniques that can be applied to a pMUT array. To keep the solution for acoustic filtering relatively simple in terms of design and fabrication, several typical solutions are considered: use of mesa-type structures, machining ring-shaped pillars of different materials on the surface and combining the trenches etched on the surface with polymer deposited inside it. A direct comparison of these approaches is made using FEM analysis, and it is demonstrated that the crosstalk in pMUT array can be reduced by the value close to the one order of magnitude.


Despite decades of agricultural policies that promoted the adoption of fertiliser and hybrid seed technologies as ways of improving productivity in maize farming, smallholder farmers in Malawi have been relatively slow to adopt the new technology. Using bivariate probit analysis and controlling for technology acquisition through grants, we found that fertiliser adoption was positively associated with higher levels of education, larger plot sizes and higher non-farm incomes, but negatively associated with households headed by women and distance from input markets. The adoption of hybrid seeds is positively associated with market-based land tenure systems and fertile soils, but negatively associated with age of the farmer and distance from input markets.


The problem of edge-disjoint path routing arises from applications in distributed memory parallel computing. We examine this problem in both the directed hypercube and two-dimensional grid topologies. Complexity results are obtained for these problems where the routing must consist entirely of shortest-length paths. Additionally, approximation algorithms are presented for the case when the routing request is of a special form known as a permutation. Permutations simply require that no vertex in the graph may be used more than once as either a source or target for a routing request. Szymanski conjectured that permutations are always routable in the directed hypercube, and this remains an open problem.


Germination and seedling development are crucial phases in a plant's life cycle with economical and agronomical implications. The RNA quality in seeds is linked to seed viability, being an important agronomic trait since this leads to a loss in germination efficiency. In addition, RNA can be an important phosphorous reservoir in seeds, affecting the efficiency of the mobilisation of nutrients towards the seedlings. However, knowledge about the physiological function of ribonucleases during germination and seedling development is scarce. We analysed the ribonuclease activities of cotyledons during these processes and the expression of S-like ribonucleases T2. Ribonuclease activity was detected in cotyledons at 1 day after imbibition and the specific activity increased during germination and seedling development, reaching a maximal value at 10 days after imbibition. At this stage, the levels of proteins and RNA in cotyledons were very low. Using in-gel assays, three ribonucleases were detected with apparent molecular masses of 16, 17 and 19 kDa along cotyledon ontogeny. The S-like ribonucleases T2 family consists of four genes in common bean (PvRNS1 to PvRNS4). The expression of PvRNS1, PvRNS2 and PvRNS4 increased in the phase of nutrient mobilisation in cotyledons. The expression of PvRNS1 increased 1000 fold in cotyledons, from 1 to 6 days after imbibition. The suppression of the induction of ribonuclease activity and gene expression in decapitated seedlings suggests that the regulatory signal comes from the developing axes. These results clearly state that S-like ribonucleases T2 are involved in RNA turnover in cotyledons during seedling development.


Hepatocellular carcinoma is one of the most common cancers worldwide. Primary known risk factors for HCC are Hepatitis C virus (HCV), Hepatitis B virus (HBV) and alcoholic liver disease. There is little information about occult HBV and its relation to HCC in chronic . We aimed to evaluate the prevalence and the possible clinical impact of occult HBV infection in chronic HCV patients with hepatocellular carcinoma. Patient and methods: A total number of 140 patients with hepatocellular carcinoma were examined, 118 patients were included in this study. They had positive HCV-RNA, negative HBsAg and radiological evidence of Hepatocellular carcinoma, previous antiviral therapy or serological evidence of autoimmune hepatitis and were divided into two groups according to their HBc-Ab status: Group (I) 93 patients positive for HBc-Ab (Occult HBV/HCV dual infection), Group (II) 25 patients negative for HBc-Ab (HCV mono infection). The rest of HCC patients were coinfected with HCV and HBV, 8 patients had HBV infection (+ve HBV sAg and –ve HCV Ab) and 4 patients had negative tests for both HCV and HBV were excluded. Results: A statistically significant increase in serum levels of AST, ALT, bilirubin, Alpha-fetoprotein with more cirrhosis, ascites, liver decompensation (according to Child-Turcott-Pugh score) and more hepatic focal lesions and malignant portal vein thrombosis (through radiological diagnosis) in Group (I) as compared to Group (II), while there was no statistically significant difference among Group (I) and Group (II) as regarding PT% or spleen size. Conclusion: Occult HBV infection is extensively common among HCC chronic hepatitis C infected patients and presence of occult HBV infection is associated with more deterioration of liver status. Key words: Occult HBV, chronic HCV, HCC.


Background and Aim: Chronic kidney disease (CKD) patients who have hypomagnesemia are at greater risk of mortality and progression. A limited amount of data is available on the prevalence of hypomagnesemia in kidney-related risk factors and chronic kidney disease patients. The present study aimed to assess the Proteinuria-associated hypomagnesemia in chronic renal disease patients: prevalence, risk factors, and effect. Patients and Method: This cross-sectional study was carried out on 128 chronic kidney disease patients in the Medicine Department of Shifa International Hospital, Rawalpindi from January 2022 to August 2022. Patients were categorized into two groups based on estimated glomerular filtration rate (eGFR) are as follows: group-I composed of Proteinuric and group-II non-proteinuric. Prior to study conduction, the ethical committee approved the protocol. Patients with prior history of ileostomy, malignancy, chronic diarrhea, colostomy, and using magnesium based medications were excluded. Detailed history, physical examination, and investigations such as serum total magnesium level (mg/dl), serum sodium level (mg/dl), serum creatinine (mg/dl), and total cholesterol and triglycerides (mg/dl) were recorded. Hypomagnesemia was defined as a serum magnesium level < 1.8 mg/dL. Results: Of the total 128 CKD patients, there were 66 (51.6%) male and 62 (48.4%) females. Group I and II had 64 patients each. The overall mean age of group-I and group-II was 48.82±12.52 and 48.21±10.64 years respectively. The prevalence of hypomagnesemia (<1.8 mg/dL) in the proteinuric group was 20 (31.3%). Diabetic patients are more susceptible to hypomagnesemia. The incidence of diabetic, hypertensive, and both diabetic and hypertensive was 12 (60%), 3 (15%), and 5 (25%) respectively among 20 hypomagnesemia. Hypomagnesemia patients had higher CRP (46 mg/L), UACR (2064 mg/g), lower serum potassium (56.4%), lower mean hemoglobin levels (10.2 g/dL), and lower serum sodium (34.9%) as compared to normomagnesemic patients 12 mg/L, 810 mg/g, 24.8%, 11.25 g/dL, and 8.6% respectively. Conclusion: The present study found that there is an independent association between hypomagnesemia and proteinuria in non-dialysis CKD patients. Anemia and hyperparathyroidism are risk factors for inflammation and anemia in CKD patients pre-dialysis. Dietary magnesium supplementation and hypomagnesemia correction may retard proteinuria and CKD progression in CKD patients. Keywords: Chronic kidney disease, Proteinuria-associated hypomagnesemia, Risk factors


Epidermal hyperplasia consisting of discrete translucent raised outgrowths of cells were observed on the skin of walleye, Stizostedion vitreum vitreum (Mitchill), during their spawning period in the spring. The cells constituting the hyperplastic growths were limited to the epidermal layer, and were associated with surface budded, 120-nm-diameter, retrovirus-like particles located in the expanded intercellular spaces. These tumour-like growths were distinct from the other virus-associated skin lesions of walleye including dermal sarcoma, lymphocystis disease and herpesvirus-associated hyperplasia. Lesions could be differentiated by careful observation in the field and comparison of portions of each growth by histologic and electron microscopic observations.


In recent years, there has been a growing interest in the use of naturally sourced fibres for use in composites design and manufacture. In this work,...


The comparative analysis of the All-Russian and regional structure of society found reflection in this article by material and property criteria which include financial position, income level, existence of accumulation and savings, structure of expenses, living conditions, car existence. The analysis showed that inhabitants of area, generally fill up those social groups in structure of the Russian society which can be carried to pressed for money, to bottoms of middle class or needy.


The comparative analysis of productive effects realized in black walnut plantations and the effects reached in natural stands of autochthonous tree species in the same forest types in Srem, taking into account also the ecological stability of stands of different origin, shows clearly that artificially established black walnut stands should be substituted by stands of pedunculate oak. The restitution of stands of high productivity and good potential assortment structure should be undertaken only after the end of the rotation. Biological and economic reasons indicate that this management treatment should be performed as soon as possible in the stands of poor health condition and low productivity.


CLINICAL VIGNETTE A37-year-old woman with type 2 diabetes mellitus and a body mass index (BMI, calculated as weight in kilograms divided by height in meters squared) of 42, diagnosed 2 days previously as positive for coronavirus disease 2019 (COVID-19) infection after exposure to her affected spouse, presents to the emergency department with vaginal bleeding. She is afebrile and has stable vital signs, normal pulmonary examination, and a nontender abdomen on examination. Pelvic ultrasound examination shows a 3.5-cm right ectopic pregnancy, with a serum human chorionic gonadotropin (hCG) level of 6,500 milli-international units/mL. You are consulted on treatment.


The invention discloses a method for calibrating double orthogonal high-precision accelerometers, and relates to the improved method for identifying an error model of the double orthogonal high-precision accelerometers, and aims to solve the problem of inaccurate accelerometer error parameter calibration caused by an angular error. The method comprises the following steps of: sleeving a polyhedral prism onto a main shaft of a grating dividing head, fixing two miniature high-precision accelerometers to be measured onto a mounting fixture in a way that the two accelerometers are vertical to each other, and fixing the mounting fixture onto the main shaft of the grating dividing head; making a light beam passing through a photoelectric auto-collimator irradiate the polyhedral prism, precisely determining zero offset terms in coefficients of the model of the accelerometers with readings at the positions of between 0 and 180 degrees, and for the positions of between 90 and 270 degrees, adopting the same method; and then obtaining each parameter of the error model by an orthogonal double-accelerometer method to finish the calibration. The method has the advantage of improving the testing precision of a gravitational field, and is particularly suitable for occasions of testing the accelerometers with precision higher than 1 mu g.


It mainly introduces the application background and features and of ASP technology, as well as the applied model in developing network database with ASP technology. Detailed procedures are presented with an example of online inquiring system for exam marks.


In this study we explored whether one pleural catheter plus single chest tube drainage could achieve a noninferior drainage effect when compared with the traditional two chest tubes in uniportal video‐assisted thoracoscopic surgery (VATS) for an upper pulmonary lobectomy.


Evaporite series is both an important target area looking for high-quality large potash deposits,but also one of the main types of hydrocarbon cap.Outcrops and drilling results indicate that five sets of evaporites were developed


ABSTRACT This work aimed to investigate the effect of five drying methods, namely hot-air drying (HD), microwave drying (MD), vacuum drying (VD), vacuum microwave drying (VMD), and vacuum freeze-drying (VFD), on the bioactive compounds, antioxidant activity, color, sensory attributes, and microstructure of purple cabbage. Different drying methods considerably affected the quality factors of the products. The highest remaining total phenolic content (TPC), total flavonoid content (TFC), and total anthocyanin content (TAC) concentrations were observed in the VFD cabbage at 10.57 mg GAE/g, 7.01 mg RE/g, 6.54 C-3-G mg eqiv/g, respectively. This was followed by the VMD samples at a TPC at 9.06 GAE mg/g, TFC level of 5.84 mg RE/g, and TAC at 3.80 C 3 – G mg eqiv/g. Furthermore, the VFD samples displayed the best performance in antioxidant activity. The antioxidant activity of the VMD samples was lower than the VD and MD samples, but higher than the HD samples. In terms of color and flavor, the VMD samples displayed a low ∆E (P < .05) value, while the flavor resembled that of fresh purple cabbage, compared to the VFD sample. According to these chemical and physical indicators and drying time. VMD is better for drying treatment of purple cabbage. Graphical Abstract


The distribution ofDTPA-extractahle micronutrient cations (Zn, Cu ,Fe and Mn) and their association with soil properties was studied in five representative soil profiles developed on different physiographic units viz., alluvial plain (Ap I, Ap2 and Ap3), alluvial plain salt affected (Ap4) and sand dunes (SD) in Fatehgarh Sahib district of Punjab. In general, DTPAextractable micronutrients were higher in surface horizons and decreased in sub-surface horizons. The content of DTPA-extractable micronutrients was highest in intensively cultivated and fine-textured soils (Ap3) and least in that of sand dunes. Based upon the linear coefficient of correlation between DTPA-extractable micronutrients and soil properties, highly significant relationship between DTPA-Zn and OC (r = 0.979*) was found in fine-textured soils of Ap3 but it had a significant positive effect on Cu availability in soils of all the physiographic units. Most of soil properties (except silt and clay) had significant effect only on DTPA-Mn in salt affected soils(Ap4). A significant negative relationship between sand content and DTPA-Zn and Cu was found in soils of alluvial plain with sand cover(Ap I). The additive effect of organic carbon was found to be more pronounced on Fe among all the micronutrient cations, irrespective of physiography. Multiple regression analysis indicates that available Zn, Cu, Fe and Mn were significantly influenced by soil properties at the level of92, 70,91 and 59 per cent respectively. Additional key words: DTPA-extractable micronutrients, physiography, distribution pattern, soil properties Micronutrient deficiencies have become one of the major constraints in sustaining crop production in the present day exploitive agriculture. The rice-wheat cropping system, being exhaustive in terms of nutrient removal, resulted in increased pressure on native nutrient reserve of soil. The deficiency of Fe and Mn has been found to occur in this cropping system (Takkar and Nayyar 1981). The availability of micronutrients is influenced by their distribution within the soil profile and other soil characteristics (Singh et al. 1989). The distribution of micronutrients may also differ among the profiles developed on different parent materials and landforms (Verma et al 2005). Keeping this in view, the present study was undertaken to study the pedospheric variations and correlation of DTPAextractable micronutrients (Fe, Cu, Zn and Mn) vis-a-vis soil characteristics for the soils developed on different land forms in Fatehgarh Sahib district of Punjab. Materials and Methods The study area is a part of Indo-Gangetic alluvial plain covering an extent of 1177 sq km. The climate of the area is characterized by a large seasonal variation as well as fluctuations both in monthly rainfall and temperature. The district falls in the semi arid region of Punjab having annual I Soil and Water Conservation and Waste Land Development Department, Ludhiana, 141004, India I


This paper presents one of the first studies on Georgian Sign Language (gesl), a sign language that has not previously been taken into consideration in typological research on sign languages. We focus on three types of indirect object markers, that is, auxiliary-like elements that introduce an additional argument. We discuss four markers in total. Interestingly, three of these markers do not only introduce an argument but also come with additional semantics, namely respect, disrespect, and causation. It will further be shown that the presence of an indirect object marker frees the word order in the sentence.


The field of education seems particularly susceptible to the allure of plausible but untested ideas and fads (especially ones that are lucrative for their inventors). One could write an interesting history of ideas based on either plausible theory or somewhat flimsy research that have come and gone over the years. And . . . once an idea takes hold, it is hard to root out. —Henry L. Roediger III, PhD


The extent to which an organism can adjust its developmental trajectory in response to environmental conditions, known as developmental plasticity, often depends on critical periods of environmental sensitivity. Here, I identify two phases of sensitivity to nutrition that regulate plasticity in ovariole number, an important determinant of fecundity and ovary size, in Drosophila. These two phases are separated by the developmental transition at critical weight. In the first highly-sensitive phase, optimal nutrition is required to promote ovary growth and to induce the onset of terminal filament cell (TFC) differentiation, which serves as a starting point for ovariole development. The second phase begins after TFC differentiation is initiated at critical weight. In this phase, the formation of terminal filaments (TFs) through intercalation of TFCs and ovary growth continue, albeit at reduced rates, in larvae that are poorly fed. These results shed a new light on how organs change their sensitivity to environmental variation at critical weight.


Antenna design, starting from scratch, using full wave analysis software can become a very time-consuming task. Using analytical (approximate) antenna models, especially at the initial stage, can reduce the overall design time considerably, as is shown in this paper. To help antenna designers, a list of common antenna types and the accompanying models is given. Two of the models have not been published, in the current form, before.


Abstract Sodium phenylacetate (NaPA) has been shown to synergize with retinoic acid (RA) in inducing the differentiation of human neuroblastoma cells. Our studies indicated that NaPA can impact on the RA differentiation program by upregulating nuclear retinoic acid receptor-β (RARβ) expression. We have found that NaPA does not alter the half-life of RARβ mRNA; thus, increased stability of mRNA levels does not contribute to NaPA induction. In contrast, NaPA was able to specifically activate a reporter gene construct (ΔSVβRE-CAT) which contains a retinoic acid response element (RAREβ) that is located in the RARβ promoter. Activation of ΔSVβRE-CAT by NaPA also occurred in neuroblastoma cells cotransfected with a nuclear retinoic acid receptor expression vector, demonstrating the independence of this activation on cellular RAR levels. Taken together, our findings suggest that induction of RARβ by NaPA is regulated at the level of transcription and mediated through the retinoic acid response element, RAREβ. This effect may account, at least in part, for the strong synergy between NaPA and RA in promoting neuroblastoma differentiation.


(Chapter 9) synthesizes the archaeological evidence in an assessment of the nature and scale of Perry Mesa political alliances. He employs ethnographic analogy to establish relevant parameters for assessing the Verde Confederacy hypothesis and concludes that the data do not support an alliance of the proposed scale. In the final chapter, Spielmann reviews evidence for the settlement and abandonment of the mesa. She concludes that people aggregated on and then left Perry Mesa as a result of both landscape and social factors. She also finds that the data do not support the Verde Confederacy model. The lack of discussion regarding lithic artifacts is a surprising omission. Obsidian data are commonly employed to analyze sociopolitical interactions in Arizona, and, given the low incidence of decorated ceramics on Perry Mesa, analyses of temporally diagnostic projectile points would provide important evidence. In general, the focus of the research is on connections with populations to the north, and mobile foragers who lived in the Perry Mesa region are given little consideration. In conclusion, the authors deserve high praise for advancing our understanding of landscape and alliance factors in central Arizona, even if this research has not yet fully resolved all of the issues surrounding the seemingly sudden appearance and disappearance of agriculturalists on Perry Mesa.


A processing route is presented to manufacture discontinuous carbon fibre reinforced polypropylene (CF.PP) composites, using much longer fibre lengths (25mm) and higher volume fractions (up to 45%) than previously reported in the literature. Carbon fibre tows are coated with different ratios of polypropylene, blended with a maleic anhydride coupling agent, to investigate the influence of the interfacial shear strength at the microscale on the macroscale composite properties. Improvements in the tensile performance at the macroscale (70% increase) are not as high as those reported for the interfacial shear strength at the microscale (300%), following the addition of the coupling agent. Consequently, the tensile strength of the CF.PP material is only 45% of values reported for carbon fibre/epoxy systems, however, the tensile stiffness is comparable. This demonstrates the potential for using CF.PP for structural applications, following further process optimisation to overcome the current high levels of porosity (3.3% at 0.45 V f ) to improve the tensile strength.


In this paper, we design a novel network architecture based on the principle of seismic impedance inversion. The network combines convolutional neural network and residual network. In seismic impedance inversion, there are usually only a few Wells. However, supervised learning requires a large number of labeled data training networks. In order to solve the above problems, this paper uses two steps to train the network. The first step, the network is pre-trained by using seismic records as the input and a large number of labeled low-frequency information as the output of the network. The second step is to train the network with seismic records as input and a small amount of well data as output of the network. The network can learn the low frequency trend of impedance through pre-training and capture the high frequency characteristics of impedance through re-training. In summary, the network learns the full-band information of impedance through two-step training. We used two typical models with different geological characteristics to prove the effectiveness of the inversion method. We used two typical models of Marmousi II and Overthrust with different geological features to prove the effectiveness of the inversion method.


Health function of Selenium element,the content and existence form of Se in tea and the Selenium-enrich mechanism of tea were reviewed in this article.This paper also summarized the influencing factors of Se content in tea and the utilization of Se-enriched tea in China.In order to provide references for further study of Se-enriched tea,this paper also predicted the development trend of Se-enriched tea in China.


Super Wideband (SWB) printed antenna with enhanced gain covering the impedance bandwidth ranging from 3-20GHz is presented. Gain enhancement of the antenna is achieved using appropriately designed frequency selective structure (FSS) acting as a band stop filter i.e. reflector, while keeping the bandwidth of antenna unchanged. The FSS used effectively reflects the in-phase radiations with a very low transmission coefficient over the entire bandwidth which is key requirement for providing antenna gain enhancement for wide frequency range. Hence significant improvement in antenna gain has been achieved using low profile and without compromising the impedance bandwidth. Results show a significant improvement in gain (i.e. 4-5dB) over the whole frequency range.


Introduction Mattole belongs to the Athabaskan language family, which is part of the Na-Dene phylum. This phylum spreads over part of the West of the North-American continent, with three separate regions of speakers: West Canada, North California and Arizona and New Mexico. Mattole was spoken in North-West California, near the mouth of the Mattole river [lit.ref. 2]. By the time it was recorded [lit.ref. 1] (1930), there were only one or two speakers left and the Encyclopedia Britannica of 1973 marks it as extinct. Other prominent Athabaskan languages are Chipewyan in Canada and Navaho and the Apache languages in Arizona and New Mexico. Mattole does not differ more from Navaho than the average British country-side dialect from Standard English; if it were not for the two thousand kilometers that separate them, they might well be considered dialects of the same language. All in all, Mattole is somewhat simpler than Navaho. If recent research is correct, the Na-Dene languages are remotely related to Chinese and arrived in America somewhere around 7000 BC.


The eye is a fascinating organ not only because of its complex anatomy but also because it is a partly immunologically privileged site, which protects itself from potentially destructive systemic immune responses. This characteristic, however, may hinder defense against infectious agents, including numerous viruses, which may manifest with a variety of ocular diseases (Table 1). The first part of this chapter discusses ocular anatomy and physiology, as well as the principle clinical syndromes, which are usually classified according to the affected anatomic structures. The latter part discusses the major viral ocular pathogens and highlights selected risk groups, such as infants and patients infected with human immunodeficiency virus (HIV).


Many floods of record in cold regions are produced by snow ablation. Accurate prediction of snowmelt runoff events by using computer models hinges upon an accurate understanding of the hydrologic role of frozen soils. This paper discusses the redistribution of soil moisture that takes place during the development of seasonal frost in a silty loam soil and the infiltration characteristics of this seasonally frozen soil. Depending upon the total (water and ice) soil moisture conditions near the ground surface, a wide range of infiltration rates can exist. This disparity in the infiltration rate results in considerable variation in the amount of snowmelt runoff.


A debate has emerged between S. Hix and S. Bartolini on the plausibility and desirability of the politicization of the EU. By this it is usually meant a more important role for mass, competitive, and partisan politics both on the input- (expression of preferences) and on the output- (collectively binding measures and resource allocation) side of the European decision-making system. In this article, we argue that this debate does not sufficiently take into consideration the consociational nature of the EU. Comparing the EU to other consociational polities such as Belgium and Switzerland, we show that the politicization of the EU is not plausible along a bipolar logic, but that other forms of politicization are both plausible and desirable. We argue that S. Hix's recipe for politicization is based on some incorrect assumptions and predictions. It is not obvious that the EU is evolving towards more Left-Right polarization. Even if this were the case, the nature of the EU implies that cooperation and compromises are indispensable, therefore Hix's suggestions will not suffice to clarify political choice and enhance accountability. Hix is not correct in believing that politicization along the Left-Right cleavage will alleviate euroskepticism. He tends to associate the latter with this dimension, which is partly wrong. Moreover, euroskepticism also has a social base ("losers of modernization") and does not only derive from the deficit of accountability in the EU. At the same time, we think that the consociational nature of the EU also reduces the risks feared by S. Bartolini with regard to the consequences of politicization on governability. The politicization of constitutive issues can even be regarded as necessary, in order to integrate anti-system political entrepreneurs and euroskeptic segments of public opinion. Also Bartolini is only partially right in stressing the destabilizing potential of the politicization of opposition on these issues: it is true that consociational mechanisms are less effective – at least in the short term – in dealing with this kind of conflict, but it seems to us less risky to rely on them than on non-politicization. As a remedy to the accountability deficit of the EU, consociational-type politicization is nevertheless not a panacea. Therefore we suggest the coupling of a system of politicized "negotiation democracy" with mechanisms of direct participation. With a number of institutional safeguards, such a coupling would help to cope with the limits of consociational systems, would remain compatible with the compound nature of the EU, and would provide value-added in terms of public legitimization of the European integration.


ABSTRACT Population decline is expected to continue to be a prominent feature of Japanese demography in future decades. Internal migration plays a significant role in dictating the intensity of population decline at the regional level. In this paper we visualize inter-prefecture internal migration flows between the eight regions of Japan in 2020 using a chord diagram to show the relative scales of the origin–destination migration flows between each region. In addition, we use an animated series of chord diagrams to show the development of internal migration between 1954 and 2020. We fix the axis of the sectors of the chord diagram in the animation to illustrate the rapid growth and then slow decline (post-1972) in the regional migration system, as well as the interruption in the movement patterns during 2011, due to the Great East Japan Earthquake.


The fluctuation return on equity of commercial banks in Nigeria over the years has been a source of concern. This is largely due to the vital roles of commercial banks in the economic growth and development of the country. The study sought to assess the effect of price levels, exchange rates and interest rates on return on equity of commercial banks in Nigeria. The study applied annual panel data for the period 2010 to 2017. Correlation analysis indicates that price levels, exchange rates and interest rates had significant correlation with return on equity of commercial banks in Nigeria. Based on the panel regression analysis, the study found that price levels had insignificant effect on return on equity (β=0.0027, p=0.0660). The study findings indicate that exchange rates had insignificant effect on return on equity (β=-0.0002, p=0.0560). Interest rates had a significant effect on return on equity (β=0.0139, p=0.0110) of commercial banks in Nigeria. The study therefore recommends that price discrimination can be employed by banks so as to apply different interest rates on loans to different customers which can be guided by their credit history. Additionally, the Central Bank should put in place effective monitoring mechanism in line with floors and ceiling for lending rates so as to protect customers from exploitation by commercial banks. Further studies can be done on the effect of price levels and exchange rates on return on equity of commercial banks in Nigeria due to the unique results obtained in this study. Keywords: Price levels, Exchange Rates, Interest Rates, Return on Equity and Commercial Banks DOI: 10.7176/RJFA/11-10-10 Publication date: May 31 st 2020


Problematic drug use is entwined with other social problems. Although vocational assistance is recognized as an important element of rehabilitation, few agencies in the UK provide such services. This report documents the support needs of drug users in education, training and employment schemes


Tunable mid-infrared sources can be created using crystals having second-order non-linearities and solid-state lasers operating in the near infrared. Such devices have already demonstrated large tuning ranges and high efficiency. Performance of these devices as well as their potential for higher output energies and narrow spectral bandwidth operation are analyzed in terms of nonlinear crystal properties and solid-state laser requirements.


There is an interest in the degree to which feeding practices contribute to early childhood obesity. We undertook a systematic review to investigate the effect of demand feeding versus scheduled feeding on obesity in early childhood. A systematic search of electronic databases identified studies relating feeding during early life mainly infancy to episodes of early childhood obesity. Included studies were assessed for quality based on study methodology, validity of dietary assessment, success of follow-up, standardised assessment of obesity. Data from ten cohorts involving 5535 subjects were included. Studies had follow-up of more than 60 %, adjusted statistically for three or more confounders and used standard criteria to determine end points. About half the studies used a validated FFQ, administered the FFQ more than once or had follow-up of one year. Fewer than half the studies involved subjects' representative of the general population. This systematic review points out the presence of heterogeneity in the results from studies reviewing feeding practices and risk of obesity. This could be due to the fact that studies are too varied in methods of feeding assessment and anthropometric measurements, time scale and the method of evaluating the nature of the association.


The paper contains the results of bit error rate (BER) performance research of the Rake receiver in multipath channel. The BER performance comparison with the non-Rake correlation receiver is presented, the method of estimation of BER performance of multipath components for the choice of optimal UWB wireless system parameters such as data rate, modulation scheme, duty cycle, pulse shape and multipath components assigned to Rake receiver fingers is proposed. Binary Pulse Position Modulation is employed as a modulation scheme.


The invention relates to a lighting system (12) for a motor vehicle (10), having motor vehicle exterior lighting devices (14, 16) and an operator control device (22) by means which the following lighting modes of the motor vehicle exterior lighting devices (14, 16) can be set: deactivated, parking light, daytime running light, forward lighting, and automatic mode in which the motor vehicle exterior lighting devices (14, 16) are operated by means of an automatic forward light controller, wherein the operator control device has a single monostable operator control element (22) by means of which the lighting modes can be set; or the operator control device (22) has a monostable operator control element by means of which the deactivated, parking light, daytime running light and forward lighting lighting modes can be set, wherein the operator control device (22) has a pushbutton key or a toggle lever by means of which the automatic mode can be set. The invention also relates to a motor vehicle (10) having a lighting system (12).


We evaluated the effects of Klotho on pulmonary vascular remodeling and cell proliferation and apoptosis in rat models with PM2.5‐induced pulmonary arterial hypertension (PAH) via the Wnt signaling pathway. After establishing rat models of PM2.5‐induced PAH, these Sprague‐Dawley male rats were randomized into control and model groups. Cells extracted from the model rats were sub‐categorized into different groups. Activation of Wnt/β‐catenin signaling transcription factor was detected by a TOPFlash/FOPFlash assay. A serial of experiment was conducted to identify the mechanism of Klotho on PHA via the Wnt signaling pathway. VEGF levels and PaCO2 content were higher in the model group, while PaO2, NO2−/NO3− content and Klotho level was lower compared to the control group. In comparison to the control group, the model group had decreased Klotho and Bax levels, and elevated Wnt‐1, β‐catenin, bcl‐2, survivin, and PCNA expression, VEGF, IL‐6, TNF‐α, TNF‐β1, and bFGF levels, as well as the percentage of pulmonary artery ring contraction. The Klotho vector, DKK‐1 and DKK‐1 + Klotho vector groups exhibited reduced cell proliferation, luciferase activity, and the expression of Wnt‐1, β‐catenin, bcl‐2, survivin, and PCNA, as well as shortened S phase compared with the blank and NC groups. Compared with the Klotho vector and DKK‐1 groups, the DKK‐1 + Klotho vector groups had reduced cell proliferation, luciferase activity, and the expression of Wnt‐1, β‐catenin, bcl‐2, survivin, and PCNA, as well as a shortened S phase. Conclusively, Klotho inhibits pulmonary vascular remodeling by inactivation of Wnt signaling pathway.


A topological space X, is shown to be compact if and only if every net in X has a cluster point. If s is a net in a product Q 2A X, where each Xis a compact topological space, then, for every subse ...


11077 Background: Response classification in RECIST is based on manual uni-dimensional quantification of changes of target lesion size. In RECIST 1.1, the maximum number of target lesions was reduc...


The paper explores the idea of 'profession' and associated matters such as professional knowledge, entry routes and what it means to be a professional. It is a personal take on the subject rather than an academic paper, though I have provided references as well as a few extracts from other of my reports or journal papers (these are italicised or in quotes, and referenced in the endnotes). The paper will be updated or added to from time to time (see above for the last revision date).


The patient is an 81-year-old man with a medical history of hypercholesterolemia and symptomatic second-degree heart block, treated by permanent transvenous dual chamber pacing via the left subclavian vein. The pacemaker was placed 5 years back. The patient was diagnosed with a stage I (T1N0M0) right lower lobe lung adenocarcinoma. He underwent a Video-assisted thoracoscopic wedge resection of the right lower lobe of the lung, intraoperative brachytherapy because of a compromised pulmonary function for a lobar resection, and with mediastinal lymph node dissection. Intraoperatively the pacemaker was interrogated and changed temporarily from a synchronous DDD mode to an asynchronous VOO mode. There were no electrophysiological events during the case. The patient received venous-thromboembolism prophylaxis with low molecular weight heparin from postoperative day 1. On postoperative day 6, he complained of swelling of the face, neck, and bilateral upper extremities. Physical exam was remarkable for swelling of the face and both upper extremities. He had a duplex venous scan of the upper extremities and the neck, which showed extensive thrombosis of the right internal jugular, subclavian, and axillary veins (Fig. 1). A computed tomography (CT) scan of chest with intravenous contrast showed thrombosis extending from the abovedelineated veins into the innominate veins and the superior venacava (SVC), usual postoperative changes in the mediastinum, and no extrinsic compression on the superior venacava (Fig. 2). What is your diagnosis? What is the incidence of this condition in relation to pacemakers? What are the predisposing factors? How does one treat this condition?


This paper introduces the transmission principle of inner cam-cranking block combination mechanism,gives the concept of the circle of balance , as well as the method of dimension synthesis. A new transmission scheme and technical guarantee is given to study the oscillator of peripheral vibration. This method is simple and practical, and the function of the oscillator designed by this method is reliable with high frequences of vibrations.


Purpose: To determine the value of screening for acromegaly in adult patients without known pituitary disease and not reporting enlargement of the extremities. Methods: A total of 887 patients presented two or more manifestations suspicious of acromegaly [hypertension, headache, excessive sweating, arthralgias, paresthesias (Carpal tunnel syndrome), fatigue] were studied. Results: Elevated serum IGF-1 levels were observed in 16 patients. When the measurement was repeated, two patients presented normal IGF-1 and adequate suppression of GH. Eleven patients with slightly elevated IGF-1 had adequate suppression of GH. No GH suppression was observed in three women with confirmed elevated IGF-1. Since serum IGF-1 was only slightly elevated, nadir GH was < 1 µg/L, magnetic resonance imaging showed a normal pituitary, and chest and abdominal computed tomography revealed no tumor, these patients were not submitted to any intervention. Conclusion: In patients without known pituitary disease, acromegaly is unlikely in the absence of growth of the extremities.


This paper deals with the subharmonic oscillations which occur in systems with nonlinear restoring force. It is first shown that the order of the subharmonics has a close connection to the form of the nonlinear characteristics. The subharmonic oscillation of order ⅓, i.e., the oscillation whose fundamental frequency is one‐third that of the applied force, is then particularly investigated for the cases in which the nonlinear characteristics are expressed by (1) cubic and (2) quintic functions. In both cases the stability problem of the periodic solution is discussed in detail according to the stability criterion given previously by the author. The analysis reveals that in the latter case (2) the second higher‐harmonic of the subharmonic, i.e., the oscillation of order ⅔ builds up with negative damping. This is verified by experiments in which the oscillation of order ⅔ causes the collapse of the original subharmonic oscillation.


Multiple sclerosis is frequently accompanied by symptoms of depression. Previous research has highlighted the impact of depression on MS disease course and treatment adherence. However, the assessm...


Due to shading of clouds and objects on the ground and due to the performance of sensors,the part region of field inversion data by remote sensing may be incomplete,which makes it harmful to use these data for further study.The way to recover the incomplete field inversion data accurately and quickly seems to be significant.Matrix completion(MC) has been proposed in recent years,which is mainly used for low rank matrix.Because of the quality of low rank,the data of the matrix has high correlation,so the matrix can be high accurately recovered with MC.SVT(Singular Value Thresholding) algorithm is one method of MC,which could recover missing values in the matrix rapidly and accurately.In this paper,we introduced the SVT algorithm for matrix completion and we used this algorithm to complete the missing data points which were selected in different regions.Making the missing data points be the center of a region of square and the size of the square is selected by the criteria of the smallest variance.Use SVT algorithm to complete this square region and name this method local SVT algorithm(LSVT).Comparing with the SVT algorithm for the whole region data that is named WSVT which is based on the whole experiment area,inversing distance weighting method(IDW) and Kriging method respectively,we conclude that the precision for LSVT is higher than WSVT and IDW method.Also,the precision changing trend for LSVT is similar with Kriging method and the precision for LSVT is higher than Kriging method in sea front region.


A pilot‐scale experimental high‐rate algal pond (HRAP) was investigated in the subarctic mid‐Sweden region, at latitude 63°N. During autumn 2002, conditions included temperatures below 10°C and photosynthetic active radiation below 200 µE/m2·s. Biochemical oxygen demand was reduced by approximately 90% (approximately 40 g/m3), chemical oxygen demand by 65% (approximately 80 g/m3), total phosphorus by 20% (approximately 1 g/m3), and total nitrogen by 46% (approximately 15 g/m3), at a retention time of approximately 2.5 days. During autumn 2003, the performance of the HRAP appeared better with a more dense microalgae culture; however, as a result of poor settling of the microalgae, the reduction was considerably lower. A major difference between the years was the microalgae composition. In 2002, the large green algae Coelastrum dominated with Chlamydomonas, Scenedesmus, Lagerheimia, and the Cryptophyte Rhodomonas. In 2003, there was a total dominance of the very small green algae Chlorella, known to be difficult to settle. In batch growth experiments during spring 2002, doubling times of 4 to 6 days were achieved. The period of temperatures above 10°C and an insolation of more than approximately 270 uE/m2·s (125 Langleys), which is well‐documented as appropriate for HRAP function ( Oswald, 1988a , 1988c ), were measured to last for 4 to 4.5 months from early May to late September. However, the growth and treatment performance experiments indicated that a longer season may be possible—6.5 to 7 months, at best—from early April to late October.


On the condition of high technology, modeling method of ground-to-air defense simulation is discussed. The achieving method with SIMAN simulation language is given. It is proved that this method is easy to understand, easy to repair and easy to extend in a study task, and is of value to modeling and simulation for other weapon systems.


this article presents a short text in di'zhke', or coatec Zapotec, in which the narrator, a participant in the Project for the documentation of the languages of Meso-america (pdLma), relates an experience from his childhood in which his family heard two ghosts one night. as part of the pdLma, a practical orthography for writing di'zhke' was established and preliminary grammatical analyses were devel-oped through text transcription as well as lexical and morphological elicitation. in the introduction to the text, updates to the orthography and linguistic analyses are provided, which are applied to the transcription of the text itself. this text, besides illustrating the grammar of the language, offers an example of how speakers of di'zhke' conceive of and refer to the dead.


This article deals with a histological problem by using image processing and feature extraction in images of renal tissues of rats and their classification through various methods such as: Bayesian inference, decision trees and support vector machines.