The present invention provides easily produced swallowing, chewing difficult to easily swallow food intake, chewing difficulties swallowing the organic gel and the gel using auxiliary feeding with food, chewing difficulties with food. The swallowing, chewing difficulties auxiliary feeding with food containing oil and fat organogel gelling agent, and which is less than 0 ℃ 40 ℃ storage modulus 1,000Pa 100,000Pa or more and less. The swallowing, chewing difficulties with swallowing containing food, chewing difficulties auxiliary feeding food organogel, ingestible food and minced or pulverized with. The swallowing, chewing difficulties method of producing a food comprising: mixing swallowing, chewing difficulties with the auxiliary feeding food organogel ingestible food and minced or pulverized, the swallowing, chewing difficulties with auxiliary feeding a food containing oil and fat with an organic gelling agent and the gel at 0 ℃ storage modulus less than 40 ℃ 100,000Pa of 1,000Pa or less.


(57) Abstract: expressing conjugated non ATPase activity in a cell, large in cells suitable substrate and then incubated achieved by producing biomass or products, other cellular metabolites or functions by inducing the conversion of ADP from ATP without affecting the production of the desired product from biomass or cells is improved. This, it is convenient to carry out by expressing a part of the F1 showing a soluble portion (F1) or ATPase activity of the membrane bound with the cell (f0f1 type) H Organism F1 ATPase or portions thereof is obtained organism or F1ATPase or part, it is expressed is selected from prokaryotic and eukaryotic organisms. Gene particular DNA encoding F1 or a portion thereof, bacteria, and which eukaryotic microbes such as yeasts and other fungi, and obtained from a cell line of higher animals, and encoding the F1 subunit β or a portion thereof , and it is selected from the group consisting of various combinations of genes encoding the gene or a portion other F1 subunits or portions thereof that. This method is particularly different levels of conjugated non ATPase activity was expressed in cells, the appropriate on a substrate by incubating the cells, substrate conversion rate of biomass or the desired product in ATPase expression levels measured, and by the conversion rate is to select the level of ATPase expression is optimized, it can be used to optimize the production of biomass or the desired product by the cells.


The utility model relates to a three-dimensional adjustable hidden hinge for a furniture door, which comprises a movable base which can be fixed on a door body, an adjustable base which can be fixed on a door frame and a hinge rotating arm connected between the movable base and the adjustable base, wherein the adjustable base is provided with eccentric adjusting rivets and adjusting screws in three-dimensional directions; the eccentric adjusting rivets and the adjusting screws, which are matched with the hinge rotating arm can realize adjustment in the three-dimensional directions. The adjustable base comprises a base plate which can be fixed on the door frame, a median plate which slides on the base plate up and down and an upper plate which slides on the median plate backwards and forwards; elongated slots matched with one another and guiding convex strips are arranged among the plates. One end of the hinge rotating arm is hinged with the upper plate, the other end of the hinge rotating arm is hinged with the movable base, and the adjusting screws which can adjust the leftward and the rightward positions of the door body are arranged on the rotating arm. The utility model can realize the three-dimensional adjustment to the door body by rotating the eccentric adjusting rivets or the adjusting screws, other set screws do not need loosening, and the utility model has the advantages of fast and easy adjustment and force and labor saving.


Salt stress index of 6 pumkin rootstock varieties were determined under a series of Ca(NO3)2 concentration(0,80,120,160,200,240 mmol/L)in sprout stage.The results showed that there were significant differnces in salt tolerance among 6 pumkin rootstock varieties after 7 d of stress treatment,and 120 mmol/L Ca(NO3)2 concentration was the effective concentration to select salt tolerance materials of pumkin.The analysis of salt tolerance of 18 pumkin selfed varieties were studied at 120 mmol/L Ca(NO3)2 concentration and the results showed that 063-2 and 045-3 had the stronger salt tolerance.


Aim: Diabetes mellitus is a metabolic disorder that causes disturbances in the electrolyte regulating mechanisms of our body. The purpose of the study was to determine the pattern of electrolyte imbalance in patients with diabetes mellitus and compare with healthy individuals; and to correlate the degree of electrolyte imbalance with control and duration of diabetes.
Methods: This cross-sectional study was conducted over a period of 6 months. It included 90 cases with diabetes mellitus and 50 cases without diabetes mellitus. All subjects had normal serum creatinine level. Serum electrolytes (sodium, potassium, chloride and bicarbonate) were measured in each subject by automated methods. The normal levels of sodium, potassium, chloride and bicarbonate were taken as 136-146, 3.5-5, 102-109 and 22-30 mmol/L respectively. Levels above or below this reference were taken as abnormal. Control of diabetes was determined by measuring HbA1c using high-performance liquid chromatography.
Result: The most common abnormalities in patients with diabetes mellitus were hypochloraemia (48.89%), low serum bicarbonate (23.33%) and hyponatraemia (11.11%), though the mean values of serum electrolytes were within the normal reference range. Serum bicarbonate level was significantly lower in the group with diabetes mellitus (p = 0.010). There were a significantly greater number of cases with hyponatraemia and hypochloraemia among cases with diabetes mellitus (p < 0.016). Serum sodium was negatively correlated with glycaemic control (r = -0.39; p <0.001) and duration of diabetes (r = -0.31; p = 0.003).
Conclusion: Electrolyte abnormalities are more common in patients with diabetes mellitus even with normal serum creatinine, and this correlates with control and duration of diabetes.


This study explores the collaborative consumption journey in purchase funnel, covering both the pre-accommodation and during/post-accommodation stages, and extends knowledge toward the intersection of customer experience and the field of shared economics. Firstly, we identify all potential touchpoints in multiple stages of the collaborative consumption journey through in-depth interviews and then we investigate experiential dimensions of the collaborative consumption journey by means of a qualitative study and the prioritization of dimensions of customer experience through the Analytical Hierarchical Process methodology by analysing two different types of access-based consumption: the renting platform Airbnb and the lending platform Couchsurfing. Touchpoints were framed under four groups: (a) brand-owned, (b) partner-owned, (c) customer-owned and (d) social/external. The results demonstrate that sensory, affective and cognitive dominant experiences act as the primary roles for both collaborative consumption platforms in the pre-accommodation stage, whereas the collaborative consumption experience is enriched with distinct experiences in the during/post-accommodation stage. The cognitive experience is relatively more important for Airbnb, while sensory experience plays


Software reliability prediction models is very helpful for developers and testers to know the phase in which corrective action need to be performed in order to achieve target reliability estimate. In this paper, an SVM-based model for software reliability forecasting is proposed. Support vector machine (SVM) is a new method based on statistical learning theory. It has been successfully used to solve nonlinear regression and time series problems. However, SVM has rarely been applied to software reliability prediction. In addition, the parameters of SVM are determined by Genetic Algorithm (GA). It is also demonstrated that only recent failure data is enough for model training. This feature that the model does not use all available failure data enables software developers and testers to obtain general ideas about software reliability in the early phase of testing process. Two types of model input data selection in the literature are employed to illustrate the performances of various prediction models. Empirical results show that the proposed model is more precise in its reliability prediction and is less dependent on the size of failure data comparing with the other forecasting models.


Contact details for image and video enquiries as well as information regarding DLR's terms of use can be found on the DLR portal imprint.


Herein, the super slippery surface composed of cluster-like ZnO@Co3O4 was prepared on the surface of Al alloy by a hydrothermal method. The morphology and composition of the film were characterized by SEM, XRD and XPS. In addition, electrochemical measurement results show that the impedance modulus at low frequency of cluster-like ZnO@Co3O4 SLIPS coatings was 6 orders of magnitude higher than that of the blank sample, and still 3 orders of magnitude towered over even after 28 days of immersion, which proves that the good storage capacity and long-term corrosion resistance.


Deliberation is often distinguished from voting. Voting is associated with self-rule through equally distributed decision power. Deliberation, by contrast, involves the exercise of persuasive influence through communication. It is thus commonly assumed that for a deliberation to produce a decision it must either (i) reach consensus, (ii) simply stop without reaching any collective decision, recommendation or concluding statement, or (iii) hold a vote. Consensus has often been taken to mean normative unanimity everybody agreeing to the same position for the same reasons. However, in this paper we specify one of the distinctive ways in which deliberating groups can arrive at collective decisions in a manner which involves neither normative unanimity nor the aggregation of fixed, prior preferences according to some pre-existing decision procedure. We describe a form of consensus that involves an agreement that arises in situ to let something stand as the position of the group, even if it is not fully shared by every member of the group. We draw in particular on Philippe Urfalino's notion of 'apparent consensus,' in which agreement to a consensus proposal is signalled not by voting, but by a manifest absence of dissent. We then explore both the dangers and the normative potentials that are involved in this use of silence in achieving consensus. The dangers involve conformity, suppression and power effects within deliberating groups. The normative potentials are realized to the extent that consensus is achieved in a context in which each participant has an effective veto. We illustrate this through an account of the production of group statements in a deliberative minipublic, emphasising in particular the surprising role of voting within the process of reaching a deliberative consensus. Alfred Moore and Kieran O'Doherty Deliberative Voting" 2


The paper hasassessed the empowerment of women underthe Panchayati Raj Institutions in Odisha.Itexamined the procedure applied for women empowerment through the elections system and reservation of seats for women. The paper more specifically investigates the elected women from scheduled castes, scheduled tribes, other backward class and general women. The PRIs has played vital role in empowering the marginalization section of the society andmore explicitly women. The social, political empowerment has been shaped after introduction of the PRIs in India. The role of the women is more important to build the society through the constitutional procedures.The Constitution of India under its principle has placed elections system to safeguard the rights of the women. The old patriarchy system of society is gradually creating space for the women. The 33 percent reservation of seats in all political institutions for women has an extraordinary amendment to empower the women.


This paper shows that a well-defined energy function can be developed to reflect the transfer conductances for multi-machine power systems under an assumption that all transmission lines have uniform R/X ratios. The energy function is derived by introducing a pure reactive equivalent system for the given system. In this study, a static energy function reflecting transfer conductances is also derived as well as the transient energy function. The proposed static energy function is applied to voltage stability analysis and tested for various sample systems. The test results show that the accuracy of voltage stability analysis can be considerably improved by reflecting transfer conductances into the energy function.


To study the seismic performance of autoclaved aerated concrete (AAC) block masonry composite wall with reinforced concrete (RC) columns, a non-linear finite element analysis has been carried out for the walls with openings using the finite element software ABAQUS. First results of finite element analysis were verified with experiment results of full-scale specimen. And then the effect of the opening's position on seismic performance was studied with finite element analysis. The result indicates that the ultimate load capacity and ultimate displacement are both increased with the upward and outward movement of the openings.


UNLABELLED
The aim of the study was to establish qualitative criteria for differentiating between malignant and benign focal lesions of the liver using unenhanced MRT at 0.5 Tesla.

PATIENTS AND METHOD
72 patients with 103 focal liver lesions were examined with T1 and T2 weighted SE sequences. The images were examined by three radiologists according to qualitative criteria (homogeneity, form and signal of the lesions compared with liver, spleen and muscle).

RESULTS
The most specific sign applying to 90% of malignant lesions were diffuse or irregular contours on T2 weighted sequences; this had a sensitivity of 43%. For all other features, specificity for malignancy was less than 67%.

CONCLUSION
Using these sequences and criteria it is not possible to distinguish between malignant and benign lesions of the liver with sufficient accuracy.


Urban parks size, spatial distribution and endowments represent essential indicators used for measuring the sustainability of urban environments and the quality of life in residential spaces. The paper assesses the deficit of urban parks in Bucharest by delimitating categories of residential spaces according to their accessibility to the city parks. We have set categories of residential spaces with poor access to urban parks and considered them to be priority intervention areas for urban rehabilitation in this aspect. Deficient access to Bucharest urban parks was correlated with development of new residential areas, as these tend to further increase the high density of built space and consequent traffic congestion. Identifying critical areas that lack good access to urban parks allows city public authorities to draw adequate measures to improve or to avoid worsening of the situation in a city with numerous environmental issues and an unpredictable future evolution. Key-Words: accessibility, housing, residential areas, urban parks, urban sustainability, Bucharest, Romania


The quality of products, maintenance operations, and transportation policies are primary concerns of managers in inventory and production planning issues. Besides that, environmental concerns and regulations are growing increasingly and attracted much attention to green production concepts such as sustainable production. Previous authors conducted a wide range of research on these problems separately. Regarding the gap of an integrated framework, we formulate a sustainable Economic Production Quantity model by considering preventive maintenance and multiple shipments of items where a portion of produced items are defective. Two different Cases are studied. In Case I, we assumed that the demand in the production period is satisfied by the produced items in the previous cycle. In another state and in Case II, simultaneous production and consumption during the production period is considered and mathematically formulated. An analytical method is presented for solving the models, and a numerical example is discussed for both Cases. Moreover, sensitivity analysis of the models is carried out, and some managerial insight is derived by changing some of the critical parameters of models. Finally, we present some directions for feature researches.


The interest in experimental data regarding thermal fuel decomposition as well as the release behavior of ash-forming elements of biomass fuels for modeling and simulation purposes is continuously increasing. On the basis of combustion experiments with lab-scale reactors and single-particle reactors, integral release data regarding ash-forming vapors can be obtained, whereby the release is calculated on the basis of analysis data of the fuel and the ash residues. At the moment, almost no time-resolved release data of ash-forming elements from single particles exist. Therefore, a single-particle reactor was designed, which has been coupled to an inductively coupled plasma mass spectrometer (ICP-MS). This reactor can be used for targeted experiments in a temperature range of 250–1050 °C under inert, reducing, and oxidizing conditions. With this reactor, it is possible to simultaneously determine the surface and center temperatures of a biomass particle, weight loss of the particle, and flue gas composition....


A to the interface, such as a functional oil base and water or functional granulosa and water are solid particles, which are used in cosmetics, the thermal stability and storage stability good emulsifying and dispersing systems formed by, and functionality required HLB value of an oily base or a functional regardless of the surface condition of the granulocyte, cosmetics and method of manufacturing the cosmetic can be emulsified and dispersed containing emulsifying dispersant capable it is an object of the present invention to provide a. A cosmetic and a manufacturing method thereof, characterized in that a polysaccharide having a A particle structure containing emulsifying dispersant and the emulsifying component mainly composed. Further, cosmetics and their preparation characterized by the presence as a three-phase emulsification dispersant emulsifying dispersant mainly comprising polysaccharide with the grain structure to form an intermediate layer was layered attached around the emulsifying component it is a method. .FIELD 1


Much attention has focused on linguistic scaffolding in language learning, little is known how a blend of scaffoldinginstructions facilitate Chinese language teaching in Putonghua-Medium-of-instruction (PMI) classroom encompassing linguistic, cognitive, cultural, affective and social (LCCAS) aspects. Lessons of a secondary school teacher who attended a professional development workshop were observed. The findings indicate that the use of different scaffolding instructions tailored to the needs of studentsenable students to achieve Chinese Language and Putonghua learning through scaffolding in various aspects: (1) provision of linguistic scaffolding to students to adapt Putonghua instruction, (2) foster cognitive development by association of students' academic background knowledge with meaningful instruction, (3) connect the cultural and historical understandings of learners with the texts, (4) develop positive attitudes towards a switch of PMI from mother tongue to arouse the learning motivation of learners, and (5) stimulation of peer interaction and cooperation. Quantitative studies and cross-case qualitative studies examining this new conceptual framework on teachers' scaffolding are suggested for future studies.


This paper presents latency and power modeling of an on-chip bus at the early stage of SoC design. The latency model is to estimate a bus throughput associated with bus configuration and behavioral model before the system-level modeling for a target SoC is established. The power model roughly calculates the power consumption of an on-chip bus including the power consumed by bus wire and bus logics. Thus, the bus architecture is determined by the trade-off between the bus throughput and power estimation obtained from the proposed bus model. We evaluate the target SoCs such as an MPEG player and a portable multimedia player so as to compare the estimated throughput from the proposed bus model to the result performed by a commercial system-level co-simulation framework. As the simulation results, the latency and power consumption of the proposed model shows 14% and 8% differences compared with the result from the validated commercial co-simulation tool.


The present invention provides a portable electronic device with a CD-ROM. The electronic device comprises a first body and the first body is received in the drive. The second drive comprises a body received in the first body, the disc assembly and laser driver. A second body rotatably coupled to the first body, said disc drive member disposed on the second body, the DVD drive member for driving the disc drive is inserted into the disc member. Said laser assembly comprising a laser head slidably received in said first body. The second body member is rotated to said disc drive head when facing the laser, the optical disc drive is in use. The drive structure is simple, and easily integrated into a portable electronic device.


The invention discloses a method and a device for obtaining minimal rate-distortion cost, belongs to the technical field of computer. The method comprises the following steps: obtaining a first code unit, wherein the first code unit is any code unit included in a video image; selecting parts of reference frames from a reference frame list; obtaining the first minimal rate-distortion cost of the first code unit based on a motion vector set and the selected parts of reference frames. The device comprises a first obtaining module, a selecting module, and a second obtaining module. The method and device are able to reduce the calculated amount of calculating the minimal rate-distortion cost, and increasing the efficiency of obtaining the minimal rate-distortion cost.


8015 Background: Cetuximab (CX) plus platinum-based chemotherapy improves overall survival (OS) in advanced NSCLC (FLEX). SWOG previously showed that EGFR FISH is associated with efficacy outcomes in patients (pts) receiving CB/P/CX (S0342). Bevacizumab (B) plus chemotherapy also increases survival (E4599) in eligible pts. Given the biologic rationale for combining EGFR and VEGFR targeted agents, S0536 investigated the safety and efficacy of carboplatin (CB), paclitaxel (P) and CX plus B.

METHODS
Eligibility: treatment-naïve advanced stage non-squamous cell NSCLC, no requirement for EGFR positivity, PS 0-1, no brain metastases or hemoptysis.

TREATMENT
CB AUC 6, P 200 mg/m2, B 15 mg/kg IV day 1 every 3 weeks, CX 400 mg/m2 day 1 then 250 mg/m2 weekly for up to 6 cycles; then B 15 mg/kg every 3 weeks and CX 250 mg/m2 weekly until progression. Primary endpoint: feasibility defined by the frequency and severity of ≥grade 4 hemorrhagic toxicities. Secondary endpoints: response rate, progression-free survival (PFS), OS and toxicity.

RESULTS
110 pts enrolled from August 2006 to September 2007; 104 assessable. Pt characteristics: median age 64 years (42-78), Male/Female 52/52, PS 0/1 43/61, stage IIIB/IV 9/95, adenocarcinoma: 81, current/former smoker: 82. Overall toxicities were acceptable and comparable to S0342 and E4599. Primary endpoint was met: grade ≥4 hemorrhage: 2% (95% CI: 0-7%). There were 4 treatment-related deaths: lung hemorrhage (2), infection (1), unknown (1). Partial response (PR): 51/95 assessable (54%; 43%-64%); Stable disease (SD): 22/95 (23%). Disease control rate (PR+SD): 77%. With median follow up of 15 months (mos), PFS is 7 mos (18 pts remain progression-free) and OS is 14 mos. 1 year survival is 57% (47-67%). EGFR IHC by H score (>0 vs 0) showed a nonsignificant trend toward improved survival: 15 vs 11 mos (p=0.14).

CONCLUSIONS
CB/P, CX plus B demonstrates safety, tolerability and efficacy in advanced NSCLC and is the most active regimen studied to date in SWOG. Additional S0536 biomarker studies including EGFR FISH will be presented. S0819, a Phase III trial of CB/P ± CX (plus B in eligible pts) is under development and is designed to validate EGFR FISH as a predictive biomarker. [Table: see text].


147 Background: Symptom monitoring plays an important role in both the physical and psychological challenges of surviving cancer. Anecdotally, cancer survival is characterized by uncertainty, symptom-related fear, and the interpretation of normal bodily sensations as symptomatic of cancer recurrence. This fear may lead to over-vigilance of benign bodily sensations, increasing anxiety and decreasing quality of life. Yet, there are few studies investigating how cancer survivors interpret and make sense of post-cancer symptoms. These studies are needed to guide considerations for clinical practice and the development of supportive interventions. Methods: We conducted in-depth semi-structured interviews with 18 AYA cancer survivors about how they interpret, manage, and respond to physical symptoms during survivorship. Participants were 15-25 years old. The sample was diverse in terms of disease history, ethnicity (8 Hispanic), and gender (9 females, 1 nonbinary). We conducted thematic analysis using a deductive coding scheme that was developed using our Cancer Threat Interpretation (CTI) theoretical model of cognitive, affective, and behavioral processes in post-cancer symptom perception. Results: AYA cancer survivors reported experiencing anxiety in the face of common physical sensations. These sensations were often interpreted as potential signs of recurrence or as late effects of treatment. Survivors most commonly reported worries about pain and fatigue, but also other sensations such as breathlessness. We coded participant transcripts into the following themes: biased attending towards symptoms, biased interpretations of symptoms as threatening, fear and worry about symptoms, and behavioral response to symptoms. In addition, we generated a new theme that was not previously captured in the CTI model: trust in the body. Conclusions: Knowing how to appraise and respond to symptoms such as pain is a challenge for AYA cancer survivors. This rich qualitative data provides support for the CTI model and suggests future directions. The results of this study can inform how clinicians talk to their patients about symptom monitoring after treatment ends.


Setting the scene The road to Wales The Myra Hess concerts Bombing raids hit London The Manod mines Temporary exhibitions The Whitehall canteen The paintings return 'home'.


INTRODUCTIONThe ongoing rapid economic and political globalization has led to the emergence of the International Federation of Accountants (IFAC) as a global authority in auditing (Loftand Humphrey, 2006). The mission of IFAC, as stated in the organisation's much-publicised website is ?the worldwide development of an accountancy profession with harmonised standards, able to provide services of consistently high quality in the public interest'2. In 2006, IFAC issued seven statements of membership obligations (SMOs) to assist ?high quality performance by professional accountants' (IFAC, 2006). The member bodies of IFAC, which includes national accountancy bodies from most of the countries in the world, are required to make their best endeavours to abide by the SMOs, and failure to do such without satisfactory explanations would result in suspension or removal of membership.The seven SMOs issued by the IFAC covers areas such as audit quality assurance, audit education, international accounting and auditing standards, code of ethics for professional auditors, and self-regulation of the auditing profession.. Although member bodies are free to have their national standards accountants, such standards would need incorporate the provisions of the IFAC SMOs and should be at least, as stringent as the IFAC statements. Earlier, Cohen, Pant and Sharp (1992), investigating IFAC's prior globalization efforts, found that acceptance and implementation of international code of professional ethics for accountants could be affected by various national cultural and socio-economic factors. MacLullich and Sucher (2005) commented that harmonisation of auditing practices had been impeded by local culture and traditions on which ethics is historically constructed. Arnold (2009) points out that effort to harmonise national regulations with international practices may threaten the auditing industry in emerging economies even more, as this might allow a few multinational accounting firms to consolidate their power and control in those economies. Cohen, Pant, and Sharp (1992) pointed out that a significant gap exists between developed and less developed countries (LDC) in terms of auditors' education, competence, and ethical perceptions, and such difference would potentially make IFAC's globalization attempts ineffective. In a recent study, Clements, Neill and Stoval (2009) investigated the extent to which 158 countries had adopted the IFAC code of ethics. The paper found that, contrary to the hypothesis that lower income countries would be less likely to adopt the IFAC code of ethics due to socio-economic factors; such countries were actually more inclined towards the adoption of the IFAC code. Clements et al commented that although lack of resources in low income countries might have resulted in such whole-sale adoption of the IFAC code, the presence of various socio-economic factors would make it very difficult for these countries to implement the code. This sets the context for this study. The objective of this paper is to investigate the suitability of the IFAC code of ethics in an emerging economy, namely Bangladesh. Using interview and questionnaire methods, we investigate whether the IFAC statements of membership obligations relating audit quality, education standards, code of ethics, and disciplinary procedures can actually be implemented in the socio-cultural environment within which the auditing profession in Bangladesh operates. In response to Chua and Poullaous (1993), this paper also investigates the dynamics of the state-profession relationship. The vulnerable political situation that prevailed in Bangladesh during 2007 and 2008 allows this study to explore the influences of donor agencies such as the World Bank on the relationship between state and the auditing profession under threats of legitimacy.Like many other low-income economies, Bangladesh has been an early adopter of the IFAC SMOs. Prior research has documented the lack of demand for audit services in Bangladesh. …


Mutations of p53 and K-ras gene have been proven to play important roles in human tumor progression. Point mutations of p53 gene located in codon 282 and K-ras gene located in codons 61 are both gene hot spot mutation regions in patients with gastric cancer. The polymerase chain reaction (PCR) fragments included codon 282 of p53 and codon 61 of K-ras gene. The PCR fragments were analyzed by single-strand conformation polymorphism (SSCP) combined with CE and polyacrylamide gel electrophoresis (PAGE). Forty-two gastric cancer patients were analyzed using two developed method. P53 gene mutation was found in 24 cases (57.2 %) and K-ras were 17 cases (40.5 %). The results showed that p53 and K-ras gene mutation in gastric cancer tissue is a usual event, and the SSCP-CE was feasible for mutation detection of p53 and K-ras gene in populations. Combined detection of p53 and K-ras gene mutations of gastric cancer tissue by PCR-SSCP has a certain value to diagnosis of gastric cancer.


Parkinson's disease is a disorder of central nervous system. It is estimated that 90 percent of people with parkinson's disease suffer from speech and voice disorders. Vocal folds are usually undermined by this disease which would lead to creation of an improper voice in the patient's speech. In this paper, various features have been extracted from the voice signals of healthy people and people suffering from parkinson's disease. Afterwards, optimized features that influenced the process of data classification were detected using genetic algorithm and ultimately, based on various numbers of optimized features, the data classification was done using KNN classification method. It was shown that a classification accuracy percent of 93.7 per 4 optimized features, an accuracy percent of 94.8 per 7 optimized features and an accuracy percent of 98.2 per 9 optimized features could be achieved which is a notable result compared to other studies.


The atlas has been compiled by an eminent Belgian rheumatologist and is attractively laid out. There are 2 or 3 radiographs on each left-hand page with matching line diagrams and a brief description on the right-hand page. The text has a certain gallic charm, many of the patients being described by occupation such as postman, headmistress, nun, etc, and is a translation as is shown by the legend under Fig. 7, which reports that the patient had suffered from 'repeated attacks of hydrops of the knees'. The atlas is divided into 4 sections-the hand and elbow, the vertebral column, the hip and shoulder and the knee and foot. Most of the illustrations deal with joint diseases, but there are a few examples of bone infections, bone tumours and metabolic diseases of bone. The preface states that 'the correct interpretation of a bone x-ray does not depend so much on the quality of the x-ray picture as on a knowledge of the patient's clinical data' and it seems possible that this comment is intended to excuse some very inferior radiographic reproductions. This may be acceptable in rare conditions where good radiographs can be difficult to obtain but is unacceptable in common conditions such as sclerotic metastases from carcinoma of the prostate, which are almost invisible on the lateral film of the lumber spine (Fig. 52) and the grossly underpenetrated film of the pelvis (Fig. 98), which is described as Paget's disease. The field covered by most of the radiographs is far too large for the abnormalities they are intended to demonstrate. This is particularly marked in Fig. 54, where a film of the abdomen is used to illustrate sacroiliitis, and in Fig. 66, where the facial bones and skull base have been included although the abnormality is confined to the apophyseal joints between the second and third cervical vertebrae. This is a serious criticism, and most of the illustrations would be improved if the field size was reduced by about half. Had this been done when the book was being prepared, it might have been possible to adjust the tone of each film, so that the radiological abnormalities shown on the line diagrams would have been clearly visible on the printed radiograph. The text sometimes seems too brief. There are 6 examples of osteoporosis which are variously described as idiopathic, primary axial, cortisone induced, postmenopausal, and generalised, but the criteria for these distinctions are not mentioned. The text which accompanies the example of spina bifida occulta (Fig. 80) does not describe the soft tissue abnormalities which are frequently associated with this condition and does not indicate that early diagnosis is desirable, as surgery can often arrest the progress of the neurological deficit. There are some curious omissions in an atlas devoted to the radiology of rheumatic disorders. For instance, there are no examples of the oblique or 'ball catcher' view of the hands, which can show small erosions not shown on the conventional anteroposterior view, and there are not oblique films of the sacroiliac joints. Despite these criticisms I enjoyed reading the atlas, which has been well printed on good thick paper. The idea is excellent and the layout clear, but the poor quality of the radiographs makes it difficult to recommend purchase by a library or individual.


THE DIFFICULTIES ARE DISCUSSED OF DETERMINING THE ECONOMIC AND SOCIAL EFFECTS ON THE COMMUNITY OF THE LOCATION OF URBAN HIGHWAYS. BOTH THE MOTORISTS AND THE COMMUNITY ARE AFFECTED BY THE LOCATION. IT IS SUGGESTED THAT BRINGING RELATIVE ECONOMIC DATA TO BEAR ON HIGHWAY LOCATION MATTERS MAY BE AIDED BY MEANS OF A SIMPLE PLUS-MINUS RANKING OF SELECTED CHARACTERISTICS RELEVANT TO ROUTE SELECTION. SUCH A RANKING, OR THAT BY SOME OTHER SYSTEM PROVIDING NUMERICAL RATINGS, WILL BE ASSISTED IF HIGHWAY STUDY FINDINGS CAN BE DISTILLED INTO A LIST OF PRINCIPLES THAT IS SUBSTANTIVE ENOUGH TO BE MEANINGFUL BUT SHORT ENOUGH TO BE MANAGEABLE. THE FOLLOWING IMPACT PRINCIPLES ARE SUGGESTED THAT MIGHT BE USEFUL IN HIGHWAY LOCATION DECISIONS: (1) INDUSTRIAL AND COMMERCIAL PROPERTIES THAT HAVE BENEFITED MORE THAN RESIDENTIAL LAND FROM A HIGHWAY NEARBY, (2) ADVERSE EFFECTS OF HIGHWAYS MAY BE MITIGATED OR ELIMINATED BY WELL-LANDSCAPED HIGHWAYS LOCATED OUTSIDE OR ON THE BORDER OF NEIGHBORHOODS OR SCHOOL DISTRICTS, (3) NEW HIGHWAYS HAVE APPARENTLY HASTENED ECONOMIC CHANGES THAT WERE PREVIOUSLY UNDER WAY, (4) LOCAL TAX ROLL LOSSES DUE TO RIGHT-OF-WAY ACQUISITION HAVE TYPICALLY BEEN OFFSET BY NEW DEVELOPMENT OR BY INTENSIFYING EXISTING DEVELOPMENT, (5) INTERCHANGE AREAS HAVE EXPERIENCED A DISPROPORTIONATELY LARGE AMOUNT OF ECONOMIC ACTIVITY, AND (6) RESIDENTS RELOCATED FROM RIGHT-OF-WAY AREAS HAVE TYPICALLY IMPROVED THEIR LIVING ACCOMMODATIONS AND INCREASED THEIR LIVING COSTS. IT DOES APPEAR THAT INDUSTRIAL AND COMMERCIAL PROPERTIES HAVE BENEFITED MORE THAN RESIDENTIAL LAND FROM HAVING A HIGHWAY NEARBY.


Abstract Purpose QX003S is a biosimilar candidate for the reference tocilizumab, Actemra®. We investigated the tolerance, variability, and pharmacokinetics (PK) of QX003S biosimilar in healthy Chinese male subjects. Design A randomised, double-blind, two-arm, parallel study was performed to examine the bioequivalence of QX003S (8 mg/kg) with that of Actemra® as a reference drug. Results QX003S (N = 40) and Actemra® (N = 40) groups exhibited similar PK properties. The inter-subject variability ranged from 14.95% to 18.78%. The 90% confidence intervals of the ratios for Cmax, AUC0–t andAUC0–∞ in both groups were within the range of 80–125%. After administration, the number of subjects who tested positive for anti-drug antibodies (ADA) in the QX003S group and Actemra® groups was 6 (14.3%) and 14 (34.1%), respectively. Adverse reactions occurred in 100% and 97.6% subjects in the QX003S and Actemra® groups, respectively. The most common adverse reactions were decrease in fibrinogen level and neutrophil and leukocyte counts. Conclusion The PK characteristics and immunogenicity exhibited by QX003S were similar to that of the reference product, Actemra®. The safety profile was similar in the two treatment groups with mild-moderate adverse effects. Trial Registration The trial is registered at Chinese Clinical Trial website (http://www.chinadrugtrials.org.cn/index.html#CTR20190002) Key points This was the first clinical report of a new proposed tocilizumab biosimilar, QX003S. This phase-I randomized, controlled study compared pharmacokinetics, variability,immunogenicity, and safety of QX003S vs. the approved tocilizumab product (Actemra@). The results demonstrate bioequivalence between BAT1806 and the reference products (Actemra@), as well as comparable immunogenicity, safety and tolerability profiles.


Athletes are prone to iterated traumatic straining of sacroiliac joints and insertion of muscles in pelvic bones. The aim of our study was to show the connection between iterated trauma and staphylococcal infection in athletes. A compilation of data concerning 22 patients, all high-ranking athletes in Sweden, with pelvic skeletal infection (symphysitis, sacroiliitis and acetabular necrosis) is presented. Most of them were ball-players, 2 females and 20 males with an average age of 21 years. The onset was acute or subacute and the disease was commonly misinterpreted, mainly as an acute abdominal disease. Four patients erroneously underwent laparotomy for suspected appendicitis. Eight patients had skin lesions (5 purulent and 3 uninfected) at the onset and thus had a portal for possible entry for a bacterial impact in the pelvic skeleton. The only verified bacterial aetiology was Staphylococcus aureus in 19 cases (culture of blood and/or aspirated samples in 18 and serology only in 1). An early scintigraphy was of greater value than X-ray for diagnosis and was positive in 8/10 evaluable cases. In all, 12/18 had early positive plain radiological findings. Another patient (#22) had, except skeletal infection, a psoas abscess, diagnosed by Magnetic Resonance Imaging (MRI). Antistaphylococcal drugs administered parenterally for 1–2 weeks followed by oral drugs for a few months comprised a successful treatment and no patient had serious sequelae or relapse. The occurrence of abdominal and/or lower back pains concomitant to fever in young persons engaged in elite team sports should lead to a suspicion of pelvic pyogenic infection. Early scintigraphy and cultures of blood and aspirated material from the infection site was essential for the diagnosis. MRI has also been shown to be valuable.


In today's turbulent business environment, an increasing number of businesses and organizations are finding themselves confronted with a crushing pressure to constantly reinvent themselves. Given s ...


This paper presents examples of practical sessions in Digital Electronics, proposed as FPGA design projects that can be debugged and/or tested either in the on-campus laboratory or online using the remote laboratory developed by the authors. This option is proposed not so much as an alternative to on-campus teaching, which it could also be, but rather as a way to supplement this form of teaching, in response to the growing demand for access to laboratory resources outside official teaching hours. The paper also includes an analysis and evaluation of students' experiences.


PURPOSE Little is known about the prevalence of opioid use disorder (OUD) among parents who are living with children and their receipt of treatment, which could reduce the harmful effects of OUD on families. METHODS We used 2015-2017 cross-sectional national survey data to estimate prevalence and treatment of opioid use disorder and other substance use disorders (SUD) among parents living with children. RESULTS An estimated 623,000 parents with opioid use disorder are living with children, and less than one-third of these parents received treatment for illicit drug or alcohol use at a specialty facility or doctor's office. Treatment rates were even lower among the more than 4,000,000 parents estimated to have other SUDs. CONCLUSION Many parents in both groups have concurrent mental health issues, including suicidal thoughts and behavior. Primary care practices can play a critical role in screening and facilitating treatment initiation.


One of the uses of new renewable energy (EBT) in Indonesia which has great potential is solar panels. Solar panels are electrical devices that are used to convert solar energy into electrical energy. The limited surface area of the panels requires users to be able to pay attention to the work efficiency of solar panels. The aspect that has the most influence on optimizing the efficiency of solar panel performance is the placement of the surface of the solar panel against incoming solar radiation. Therefore, it is necessary to have a method to detect the position of the sun to provide input to the actuator so that the surface of the solar panel is positioned in the direction of the sun's rays. This study describes the accuracy of detecting the position of the sun using digital image processing methods. This process needs to be done as a reference in designing a dual axis solar tracker. Detection of the sun's position using this method gets 100% accurate results in cloudless sky conditions and gets 80% success results in cloudy sky conditions.


Summary of Results FocalsalvagetherapyusingHIFUforradiorecurrentpros-tate cancer is feasible and appears to exhibit a favorablebalance of harms and benefits. It can be carried out as ashort-stay procedure with encouraging genitourinary andbowel toxicity in the high-risk group that we studied. Inthe short follow-up of this study, the cancer control ratesappeartobeencouraging. Limitations Before discussing the clinical implicationsof these results,it is important to detail the limitationsof our study. First,the series had a short follow-up. Although our primaryobjective was to evaluate side effects and adverse events offocal salvage therapy, we believed it was important toreportthelimitedcancercontroloutcomes.Second,approximately50%ofmenunderwentmp-MRI after a 10 to 12 core TRUS biopsy that was per-formed before referral to our center, provided thesematched in terms of the positive side of salvage hemiabla-tion. Although we accept that this may have lead to miss-ing clinically significant disease in untreated areas, webelieve that this error was very low as a result of the 95%negative predictive value of mp-MRI for clinically signifi-cant disease after EBRT indicated from our own resultsusing mp-MRI versus TPM biopsies


We document that the term structures of risk-neutral expected loss and gain uncertainty on the SP (2) disentangling the price of negative jump risk from its positive analog in the stochastic discount factor speci fication; (3) specifying three latent factors.


ABSTRACT This purpose is to know the influence of compensation, motivation, work discipline, to employee performance. This study analyzes the influence of the director of compensation, motivation, and work discipline on employee performance. Motede data analysis used in this research is Multiple Linear Regression Analysis. Based on the results of this study that the compensation positive and significant impact on employee performance, this is evidenced from the value of variable coefficient of 6288 and significant value of 0.000. Negative and insignificant motivations on employee performance, this is evidenced from the value of the variable coefficient of -1.156 and a significant value of 0.258. Work discipline of influence and significant to employee performance, this is evidenced from the value of variable coefficient of 5,534 and significant value of 0.000. As well as the significant value of Fuji <0.05, where H4 is accepted, which means there are some independent variables that have the ability to explain the dependent variable (employee performance). Keywords: Compensation, Motivation, Work Discipline and Employee Performance


The purpose of this paper is to provide solution to increase the efficiency of Turnaround time of truck at Aavin milk dairy Erode. The time taken to complete the tasks assigned to the trucks inside the industry is known as the turnaround time of the truck. If the number of processes is higher then automatically the vehicle turnaround time will be also higher. There are some movements that could be omitted where the time consuming is large. Logistics plays an important role in every industry where the arrival time and the exit time of the truck matters a lot. The research project is mainly focused on finding the turnaround time of the trucks and reducing it. The readings were taken manually by studying the time of truck at check in process, in weighment area, in taking sample, clearance, time study in unloading and time study of truck in the cleaning & exit area. The crew size management is also studied. Here the size of the crew is not enough to carry out the operations in a well efficient phase. Time is wasted in some operations that affects the efficiency, so relevant crew size is suggested to cut down the wastage of time. During the cleaning of the milk tanker there is a wastage of some raw milk from the tanker after the unloading the process, for this the fish bone diagram is drafted to give solutions to the problem. Thus, on implementing these would definitely bring a huge change to the company by increasing its efficiency and competing effectively with their competitors.


This digest paper describes the experimental demonstration of two dimensional (2D) microscale `Chladni figure'-like patterns [1] of populations of microspheres in liquid using SiC micromechanical resonators. SiC square trampoline resonators (size: 50μm×50μm) exhibit appreciable high frequency multimode resonances when operating in liquid. We are able to manipulate relatively small (1.7μm in diameter) and large (7.75μm in diameter) microspheres by resonant excitation of the trampolines and create a series of 2D microscale Chladni patterns (corresponding to specific mode shapes), from simple to complex. This SiC resonator platform may offer new opportunities for microparticle patterning by taking advantage of its straightforward device fabrication and engineerable multiple modes, and further facilitate cell manipulation, cellular interaction and behavior controlling, and other biophysical and biomedical studies in liquid.


We analyze the potential of the Fermilab Tevatron and CERN Large Hadron Collider (LHC) to study anomalous quartic vector--boson interactions (photon photon Z Z) and (photon photon W+ W-). Working in the framework of SU(2)_L X U(1)_Y chiral Lagrangians, we study the production of photons pairs accompanied by (e+e-), (e nu), and jet pairs to impose bounds on these new couplings, taking into account the unitarity constraints. We compare our findings with the indirect limits coming from precision electroweak measurements as well as with presently available direct searches at LEPII. We show that the Tevatron Run II can provide limits on these quartic limits which are of the same order of magnitude as the existing bounds from LEPII searches. LHC will be able to tighten considerably the direct constraints on these possible new interactions, leading to more stringent limits than the presently available indirect ones.


While the containerization and intermodal transportation become widespread, dry ports within the transport network in the hinterland of a sea port have begun to play an important role in freight transport. In addition to providing the opportunity to expand the hinterland of sea ports, a dry port can also relieve a sea port that is experiencing capacity problems. It is thought that the total capacity of Kocaeli container terminals, which play an active role in Turkish foreign trade, may be insufficient to meet the needs in the coming years and therefore a dry port to be established in the region may support the seaports in increasing their throughput volumes. The Kosekoy logistics center, which is considered to be a suitable candidate in this regard, has been examined in terms of the facilities and capabilities it has to possess, and the minimum land area of that dry port has been determined by taking into account the demand of 2035 through a mathematical model. In this study, it is assessed that the Kosekoy logistics center has enough space to construct the required facilities in supporting the ports in the region in terms of container transportation, however, it must acquire new abilities. On the other hand, it is considered necessary that TCDD (Turkish Republic State Railways) complete its infrastructure investments to increase the freight transport capacity to a minimum one million TEU a year between Gebze and Kosekoy.


Objective To explore an appropriate participatory teaching form in the teaching of Obstetric and Gynecological Nursing. Methods Totally 120 nursing students enrolled in 2006 were divided into Class A (n=60) and Class B (n=60). In the teaching of Obstetric and Gynecological Nursing,Class A adopted "ten minutes in class" teaching method,while Class B adopted conventional teaching method. By the end of the course,a self-designed questionnaire was used to compare the evalu- ation of teachers and students. Results More than 80% students in Class A thought that "ten minutes in class" teaching method improved their learning initiative and comprehensive qualities. The students in Class A were obviously better in the aspects of study enthusiasm,basic knowledge and application abilities than the students in class B. Conclusions "Ten minutes in class" teaching method embodies student-centered teaching philosophy,and it improves students' enthusiasm and compre- hensive abilities and contributes to improving teaching quality.


ABSTRACT: PIRES, J. C.; CAMARGO FILHO, S. T.; CARVALHO, S. R. de; PIRES JUNIOR, J. C. Evaluation of a milk production system of a interbred Holland x Gir herd pasturing exclusively on grasses in the region of Medio Paraiba, State of Rio de Janeiro. Revista Universidade Rural: Serie Ciencias da Vida, Seropedica, RJ: EDUR, v.23, n.2, p. 1-7, jul.- dez., 2003. A milk production system exclusively based on pasturing was conceived aiming the improvement of production indexes specially relating to the lactation period over the annual seasons. The study was carried out in Pinheiral, State of Rio de Janeiro, Brazil, from november 1983 to october 1993. An area of 25.6ha divided into eight hedged plots with approximately 3.2ha each was formed by Digitaria decumbens cv. Transvala, Digitaria swazilandensis, Cynodon nlemfluensis and Brachiaria mutica. At pasture settlement it were incorporated in the soil 100kg P,O/ha as rock phosphate and 20kg P,Q,fha as super-phosphate distributed in the planting rows. After grass establishment 50kg/ha of nitrogen were applied as a covering fertilizer over the first year. The occupation of the pasture plots followed a rotational scheme. Results of 216 computed lactations were not influenced by the delivery season (rainy or dry) with an overall daily production mean value of 10.1kg of milk per cow. The 1/2 and 3/4 Holland animais had a similar performance with daily produc!ion averaging 10.7kg/ cow whereas the 7/8 Holland group showed a lower potential with mean value of 9.0kg/cow/day. Milk production during rainy period reached the average of 10.9kg against 9.3kg/cow/day on dry seasons.


A series of Sc:Er:LiNbO3 crystals have been grown by Czochralski method. Their ultraviolet‐visible (UV‐Vis) absorption spectra was measured and discussed to investigate their defect structure. The optical damage resistance of Sc:Er:LiNbO3 crystals was characterized by the transmitted beam pattern distortion method. It increases remarkably when the concentration of Sc2O3 exceeds a threshold concentration. The optical damage resistance of Sc (3.0mol %):Er:LiNbO3 is much higher than that of the Er:LiNbO3. The intrinsic and extrinsic defects were discussed to explain the enhance of the optical damage resistance in the Sc:Er:LiNbO3 crystals. (© 2005 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)


While iron-bisphosphines have emerged as effective catalysts for C-C cross-coupling, the nature of the in situ formed iron species, elucidation of the active catalysts and the mechanisms of catalysis have remained elusive. A combination of (57)Fe Mössbauer and magnetic circular dichroism (MCD) spectroscopies of well-defined and in situ formed mesityl-iron(II)-SciOPP species combined with density functional theory (DFT) investigations provides the first direct insight into electronic structure, bonding and in situ speciation of mesityl-iron(II)-bisphosphines in the Kumada cross-coupling of MesMgBr and primary alkyl halides using FeCl2(SciOPP). Combined with freeze-trapped solution Mössbauer studies of reactions with primary alkyl halides, these studies demonstrate that distorted square-planar FeMes2(SciOPP) is the active catalyst for cross-coupling and provide insight into the molecular-level mechanism of catalysis. These studies also define the effects of key reaction protocol details, including the role of the slow Grignard addition method and the addition of excess SciOPP ligand, in leading to high product yields and selectivities.


Three males and one female with alternating skew deviation are reported. All of them showed adducting hypotropia in the lateral gaze for less than one month, which resolved. Duction was full in each direction. Three had brainstem tumor and one had a history of viral encephalitis. All of them had accompanying pretectal signs, such as upward gaze palsy, defective pupillary reaction, and nystagmus. Patients with alternating skew with pretectal signs may need urgent surgical intervention.


627 Background: IDH-1 mutations are common in AML, gliomas, and intrahepatic cholangiocarcinoma. The enzyme product of the IDH-1 R132 variant preferentially catalyzes the NADPH-dependent reduction of alpha-ketoglutarate to the oncometabolite R-2-Hydroxyglutarate (R-2HG), resulting in accumulation of R-2HG, relative to its enantiomer, S-2HG. Elevated plasma levels of 2HG and/or higher ratios of R/S have been observed in AML and intrahepatic cholangiocarinoma, but not in gliomas. Only a few cases of IDH-1/2 mutations have been reported in advanced colorectal cancers (CRC). We investigated plasma levels of 2HG and relative ratios of R/S in CRC patients harboring IDH-1/2mutations. Methods: Between 2012 and 2015, 428 patients with advanced CRC were molecularly profiled through the COMPACT and IMPACT programs at the Princess Margaret Cancer Centre. Tumor DNAs were isolated from FFPE archived samples and genotyped using a customized Sequenom panel or Illumina MiSeq TruSeq Amplicon Cancer Panel in a CLIA-certifie...


Monolithic mode-locked semiconductor lasers are compact and stable sources of ultrashort optical pulses with GHz to multihundred GHz repetition rates. By building the whole mode-locked laser on a single piece of semiconductor, the tedious optical alignment process with bulk optical elements are totally eliminated. The mechanical and temperature stability are also greatly enhanced because of the integrated cavity and the small volume.


Adolescence is a stage of life marked by important developments, namely physical, psychological, emotional, and social aspects. In recent years, adolescent mental health has received increasing attention from experts. This is because the early age of the first episode of mental disorders occurs at the age before 14 years. Adolescents at SMPN 21 Tanjung Jabung Timur do not know about mental health in adolescents. This community service activity aims to help increase the knowledge of young people at SMPN 21 Tanjung Jabung Timur about mental health and how to handle it early if mental health problems occur in friends at school. This community service activity was carried out at SMP Negeri 21 East Tanjung Jabung Regency as a health partner. The methods used are lectures, discussions, pre-test and post-test measurements of mental health conditions in adolescents. The results of the activity showed an increase in adolescent knowledge about mental health after being given mental health education by 74.4%. Mental health education is important to do as an effort to prevent mental health problems in adolescents.


McLean, Gary A., M.A., September 1983 Anthropology Archaeology and Cultural Resource Management: A Case Study from the Ashland Division, Custer National Forest, Montana Archaeologists have suggested different settlement and sub sistence patterns of the prehistoric human occupants in Southeastern Montana. Prehistoric human behavior is, at least partially, reflected in the archaeological record. The purpose of this research is to analyze some of the data collected from the area to evaluate the different settlement and subsistence patterns that have been suggested. Using the chipped-stone artifact assemblage collected in a .. 1974 archaeological inventory, five hypotheses relating to prehistoric settlement/subsistence patterns are examined. In analyzing the functional attributes of the artifact assemblage observed, certain activity areas are identified that relate to prehistoric human settlement and subsistence patterns. This research identifies prehistoric human activities based on the artifact assemblage, not on the more subjective notion of site type. It also illustrates the need for an approach to cultural resource management that is compatible with anthropological theory. In the final analysis, a localized transhumance settlement and subsistence pattern is not in dicated. Likewise, a shift in settlement patterns over time is rejected. Director: Dee C. Taylor


In order to overcome the drawbacks such as slow execution speed and high mismatch rate in directly apply SIFT feature to vehicle plate extraction,this paper proposed a two steps vehicle plate extraction method based on SIFT feature and HSV color space.First roughed location the candidate region use HSV color space in a short time,then adopted SIFT feature to locate the plate precisely and correct the tilt,in the meantime accomplished the recognition task of the Chinese character on the vehicle plate.Through the approach not only reduced the computation of SIFT feature,but also avoided the background interference,so can match the features fast and correct.Experimental results also show that the method has a good performance.


DNA sequencing today produces vast amounts of image data in the final recording process. For example, Solexapsilas sequencing by synthesis platform allows the outcome of sequencing reactions to be observed simultaneously at a resolution of millions of individual DNA molecules. Recording the outcome after each reaction therefore, generates terabytes of image data in the course experimentation. For posterity reasons some of this image data needs to be preserved for longer term and therefore we need compression schemes with high compression ratios while data fidelity needs to be preserved. This paper describes the design and implementation of a novel compression scheme for archiving DNA Sequencing Images produced during the sequencing by synthesis procedure. The scheme is based on the identification of information points in the sequencing images, and regeneration of the whole image using these, exploiting diffraction characteristics of point sources of light. It provides for a high compression ratio of 1:10 to 1:20, while still maintaining acceptable fidelity of the information.


Abstract : Sustained operations necessarily conflict with the circadian system in several ways: changes in the habitual work-rest cycle, shifts in meal- or sleep-timing, intense activity during night hours, sleep deprivation and disruptions of the normal synchrony between body functions and environment. When these rhythm disturbances affect performance, they become operationally significant. Their consequences are discussed and factors are described which influence the range of performance oscillation. Of particular operational relevance are motivation, sleep and physical exercise. Under certain conditions they can help to overcome deficits in performance and periods of diminished efficiency.


Dynamic write inhibit (DWI) is a method of selectively inhibiting the programming (writing) of nonvolatile semiconductor memory cells. Its primary use is in silicon nitride oxide semiconductor (SNOS) and metal nitride oxide semiconductor (MNOS) memories, although it may be generalized to other nonvolatile technologies. This technique is based on a mechanism generally known as deep-depletion channel shielding (DDCS). A characterization of this phenomenon from the vantage points of analytic, experimental, and numerical simulations is presented. In addition, a brief review of the literature and the introduction of a novel memory cell used in a 64K nonvolatile static random access memory (nvSRAM) demonstrate the need for this better physical understanding. >


It has taken some two decades for the concept of the learning organisation to achieve recognition as a powerful way of reengineering for life long learning. During this time, schools have been through a period of very rapid change but, paradoxically, many look less like learning organisations today than they may have before the introduction of the Education Reform Act. This paper examines some of the key ideas behind the learning organisation, explores why the concept is so powerful in contemporary contexts, identifies various types of learning organisations and suggests an analytical technique for relating styles of organisational learning to the environmental context. The paper concludes with an analysis of the implications of learning organisation concepts for schools and school leaders.


The invention discloses a method for separating and purifying huperzine by a molecular imprinting technology, which includes the following steps: 1 huperzia serrata is smashed and extracted in ultrasonic counter-current mode, obtained extracting solution is decompressed and concentrated, and then active carbon is added in the extracting solution to perform decoloration; 2 the decolorized extracting solution is arranged on a solid phase column, huperzine molecular imprinting polymer serving as a solid phase is installed in the solid phase column, 5% to 10% of ethanol water or methanol water is used for elution, 40% to 50% of ethanol water or methanol water is used for elution till eluent is colorless, an disassembling column enables the solid phase to be taken out from the solid phase column, and 60% to 70% of ethanol water or methanol water is used for extracting adsorbed huperzine monomers in the solid phase to obtain extraction liquid; and 3 the extraction liquid is decompressed, concentrated and recrystallized by using solvent to obtain the huperzine. The method for preparing the huperzine has the advantages of being safe, easy and simple to operate, low in cost, short in production cycle, high in purity and the like.


We numerically investigate the pulse compression mechanism in the infrared spectral range based on the successive action of nonlinear pulse propagation in a hollow-core fiber followed by linear propagation through bulk material. We found an excellent agreement of simulated pulse properties with experimental results at 1.8 {mu}m in the two-optical-cycle regime close to the Fourier limit. In particular, the spectral phase asymmetry attributable to self-steepening combined with self-phase modulation is a necessary prerequisite for subsequent compensation by the phase introduced by glass material in the anomalous dispersion regime. The excellent agreement of the model enabled simulating pressure and wavelength tunability of sub-two cycles in the range from 1.5 to 4 {mu}m with this cost-efficient and robust approach.


Islanding in power system can be intentional or unintentional. In the past most of the methods were developed for the phenomenon of unintentional islanding. Recently as the distributed generator (DG) sources are able to control voltage and frequency in the islanded part, the phenomenon of unintentional islanded is not common. If the autonomous operation of sources or intentional islanding is desired, then a fast islanding detection technique is necessary . The main philosophy of detecting an islanding situation is to monitor the DG output parameters and system parameters to decide whether or not an islanding situation has occurred from change in the parameters. islanding detection techniques can be classified as remote techniques and local techniques, and local techniques can be divided into passive methods, active methods and hybrid methods. In this paper, several remote and local techniques (passive, active, and hybrid methods) for islanding detection are briefly described. The advantage and limitation of each technique are also introduced. Meanwhile, the comparison of these methods is also discussed.


here with truth: there is the high-minded concern of the artist and there is the more pragmatic concern of the despised and falsely convicted man writing his "apologia." The careful juxtaposition of these two appeals to truth is a central theme in The Black Prince. The bulk of the novel purports to be a first-person narration of events in the later life of Bradley Pearson. Bradley is a writer who has been waiting patiently and silently for the inspiration, "the dark blaze," to produce a great work of art. This "dark blaze" eventually shows itself as the "black Eros," in a passionate but short-lived love affair with the young Julian Baffin. Bradley is reflecting on these events from his prison cell, guided by his mentor and fellow prisoner, the "editor" P. Loxias (a witty reference to Apollo, god of truth). He sees his art and his love as stemming "from the same source" (p. 172) and, although sensitive to his shortcomings as an artist, he believes that through a divine inspiration he has attained a kind of Platonic tranquillity in the presence of truth and self-knowledge. However, through the device of "postscripts," purportedly written by other characters, we are presented with another picture of him rather different from his own. His former friends, more down to earth, though variously self-interested, depict him as a pitiful, even contemptible, charlatan lost in fantasy and delusion and a suitable case for psychoanalysis. What, then, is the real Bradley Pearson? Is he the pathetic, fantasy-ridden creature of the "postscripts"? Or is he, as he thinks, the great artist inspired by the gods and by Eros who has seen the revelation of truth?


The hydrolysis of Tripolyphophate and pyrophophate was studied in chicken leg meat by 31P NMR.There werethree groups fresh chicken leg meat. One was treated with 5% NaCl solution as the control. The other was treated with 5%NaCl+6%TSPP solution and another was treated with 5%NaCl +6%STPP solution. The injection rate of marinate into chicken legmeat was 200ml/kg.TSPP and STPP were found to be hydrolyzed in chicken leg meat. TSPP was hydrolyzed to monophosphate.STPP was hydrolyzed to orthphosphate and pyrophosphate, whereas pyrophosphate was hydrolyzed to monophosphate. Thespeed of the hydrolysis of STPP was higher than the speed of TSPP.


Alkylphospholipids are a novel class of antineoplastic drugs showing remarkable therapeutic potential. Among them, Erufosine (EPC3) is a promising drug for the treatment of several types of tumors which has not been sufficiently characterized. While EPC3 is supposed to exert its function by interacting with lipid membranes, the exact molecular mechanisms involved are not known yet. In this work, we applied a combination of several fluorescence microscopy techniques (i.e., scanning fluorescence correlation spectroscopy, line-scan fluorescence correlation spectroscopy and generalized polarization imaging) to quantify the effect of EPC3 in biophysical models of the plasma membrane, as well as in cancer cell lines. Our results indicate that EPC3 affects lipid-lipid interactions in cellular membranes by decreasing lipid packing and increasing membrane disorder and fluidity. As a consequence of these alterations in the lateral organization of lipid bilayers, the diffusive dynamics of membrane proteins are also significantly increased. Taken together, these findings suggest that the mechanism of action of EPC3 might be linked to its effects on fundamental biophysical properties of lipid membranes in cancer cells.


In the 21st century, the global economic integration and the China-US Trade frictions are becoming more and more complicated and the United States' pressure about the trade imbalance between China and the US is severe. The United States has increased its crackdown on intellectual property products from China and used The "Special Section 301 " and "307 Survey" to restrict China's exports considering the high pressure of trade imbalance between China and the United States. Compared with the intellectual property legal system, China, which is developing relatively rapidly in the intellectual property industry, is constantly striving to improve the authority of intellectual property rights in China from various aspects such as law, enterprise and society for accelerating the construction of innovative country. Chinese enterprises should correctly understand the differences between China and the United States in the field of intellectual property law, seize the core of China-US intellectual property trade friction, and improve the core competitiveness of innovation based on the characteristics of their own enterprises, in order to get an superior position in property rights trade. The article summarizes the causes and characteristics of trade friction through analysis of the two countries, and proposes political, economic and legal aspects for Chinese enterprises through actual case analysis. The suggestions and strategy choices are given after the strengths, weaknesses, opportunities and threats analysis (SWOT) faced by Chinese IP companies.


Aims: As a result of several factors such as excessive use of drug, bacteria can resist against antibiotics. Anti- biogram test is used to assess the antibiotic or the other antimicrobial agents' ability in prevention from bacteria's growth in laboratory. Based on the CLSI data in January 2006, regarding the disc diffusion test, the effect of 92 antibiotics have been evaluated with 329 different tests with different bacteria. Common standard disc dispensing is carried out with 15mm distance from the plate border. The aim of the study was to introduce a new tool for measuring the microorganisms' sensitivity to antibiotics. Materials & Methods: In the graded new plate and its using method, disc dispensing was done without any distance from plate border and using a full or half-disk. Results: The lack of distance from plate border, not only had no negative effect on the results but also led to the higher accuracy and reduction of problems and errors and unwanted interference in the previous methods. Conclusion: The use of this plate and its method increases the efficiency of the disc diffusion test between 3- 17% in the plates with standard sizes of 84-120 mm.


This paper discusses the data retention properties of ONO interpolysilicon dielectrics. Several low thermal budget recipes of bottom oxide are compared to improve FLASH E2PROM cells shrinkage toward 64 Mb generation. Best results are obtained for LPCVD bottom oxide against chlorinated and dry ones.


The late 1960's saw the impo r t an t discovery of the C4-dicarboxyl ic pho tosynthet ic pathway, wh ic h was fo llowed by the revelation that a carbon di oxide concentrat ing mechan ism ope rates in certain terrestrial higher plants to ra ise the C02: 02 concentration ratio at the s ite of the carboxylating enzyme, Rubisco . A decade o r so later a group of researchers at the Carne gie Laboratory at Stanford led by Joseph Berry demonstrated that a C02-con centrating mechani sm also operates in unicellular aquat ic plants . Unlike its counterpart in terrest rial plants, this mechanism does not depend on a metabol ic cycle. The lo wer plant C02 concentrat ing mechanism has not in the past received the general attention given to the higher plant counterpart, but the fact that the Organizing Committee of this Congres s has judged it worthy of being the topic of our symposium here today is a clear s ign of growing interest in the phenomenon .


In a world in which war crimes, crimes against humanity, and genocide are not uncommon, the institution that was set up to have jurisdiction over them is in danger of being unable to discharge its mandate. Put starkly, the International Criminal Court (ICC) suffers too frequently from an inability to arrest or otherwise detain alleged perpetrators, whether the prosecutor is acting proprio motu or is following a reference to the court by a state party or the Security Council. The situation of Saif al-Islam Gaddafi is a case in point: notwithstanding the Security Council's referral of Libya to the ICC, at least as a member of the public it is difficult to detect any substantial international pressure that has been applied to have Gaddafi transferred to the Court; instead, he has been mooted as a candidate in future presidential elections. In total, the Court has issued thirty-two arrest warrants and nine summonses to appear, yet has held only nine individuals in custody, with fifteen still at large. The fugitives include citizens of the Democratic Republic of Congo, Uganda, Sudan, Kenya, Libya, and the Ivory Coast. Once the present trials before the court have concluded, there is only one case potentially waiting in the wings. A sole outstanding individual, Al-Hassan Ag Abdoul Aziz Ag Mohamed Ag Mahmoud from Mali, has made an initial appearance, and later this year the pre-trial stage of his case should commence; otherwise, there are simply the three trials in progress. However, I urge careful reflection before the Court is blamed for periods in which its docket of cases is lean.


In this paper we describe a genetic algorithm approach able to confection strong backgammon automata players. We first prepared an initial vector of weights representing a set of heuristic strategies suggested by expert human players. Then, employing a genetic algorithm approach we were able to fine tune such initial vector of weights by repeatedly testing it against Pubeval, a strong benchmark player program. The vector of weights was therefore used as an evaluation function for performing a genetic heuristic selection of the best board positions during a game. Best GA-Gammon individuals so obtained were tested in separated 5000-game tournaments against Pubeval itself, and Fuzzeval, a fuzzy controllerbased player. Our experimental results indicate that the best individuals generated by GAGammon show similar performance than Pubeval. Furthermore, GA-Gammon consistently outperforms Fuzzeval.


Two series of fluorinated chalcones containing morpholine and imidazole‐based compounds (f1–f8) were synthesized and evaluated for recombinant human monoamine oxidase (MAO)‐A and ‐B as well as acetylcholinesterase inhibitory activities. Our results indicate that morpholine containing chalcones are highly selective MAO‐B inhibitors having reversibility properties. All the imidazole‐based fluorinated chalcones showed weak MAO inhibitions in both isoforms. Among the tested compounds, (2E)‐3‐(3‐fluorophenyl)‐1‐[4‐(morpholin‐4‐yl)phenyl]prop‐2‐en‐1‐one (f2) showed potent inhibitory activity for recombinant human MAO‐B (IC50 = 0.087 μM) with a high selectivity index (SI) of 517.2. In the recovery experiments using dialysis, the residual activity of MAO‐B inhibited by f2 was close to that with the reversible reference inhibitor. Inhibition assays revealed that the Ki values of f1 and f2 for MAO‐B were 0.027 and 0.020 μM, respectively, with competitive patterns. All the morpholine‐based compounds (f1–f4) showed moderate inhibition toward acetylcholinesterase with IC50 values ranging between 24 and 54 μM. All morpholine‐containing compounds exhibit good blood–brain barrier permeation in the PAMPA method. The rational approach regarding the highly selective MAO‐B inhibitor f2 was further ascertained by induced fit docking and molecular dynamics simulation studies.


High energy 13.5 nm EUV (~92 eV) induced Ge MOSFET degradation is reportedly for the first time. The degradation of threshold voltage, subthreshold swing, and channel mobility is attributed to the generation of interface traps and oxide fixed charges. Much more severe degradation of S.S. on nFETs as compared to pFETs suggests that acceptor type Dit in the upper half of Ge bandgap are generated by EUV radiation. ΔQit may originate from the dangling bonds at interface. Positive ΔQf is due to the fixed charges of oxygen vacancy. The generation of bulk defects in Ge increases the drain leakage current, leading to the reduction of current on/off ratio.


Abstract While most research on electoral monitors has focused on the effect of electoral monitors on politicians and their behavior in terms of committing electoral fraud, this study examines the effect of electoral monitors on citizens, and their effect, in particular, on people's perceptions of electoral integrity and behavior in terms of turnout at the polls. To examine this relationship, I conducted a field experiment around the 2009/2010 municipal elections in Kosova, which varied the amount of information people had about the responsibilities of monitors in these elections. In the experiment, people who had more information about the monitors' responsibilities believed that the elections were more free and fair than those who had less information, and also believed that the monitors helped make these elections more free and fair, even though they were not more likely to vote as a result.


As the editors say in their preface, the seventy years celebrated in this Festschrift have seen the development of nearly all the body of knowledge which we would describe to-day as geophysics. In fact, the thirty-seven years since Jeffrey's first edition of The Earth have seen such factual changes in his material that to-day what remains is the logic of his division of the subject and of his method of attack on the problems of each division. The fourth edition of The Earth is, apart from this, a different book. Is the book we are considering here the fifth edition ? No. It is a collection of twenty-seven papers by thirty-four contributors who include many of the prominent names of the contemporary science. Their writings are grouped to emphasize the breadth of interests of the man they honour : the earth's gravitational field and geodesy, seismology-body waves, seismology-surface waves, free oscillations, thermal state, composition, atmosphere and oceans, and instruments. The occasional paper seems a review of the present state of its subject ; the majority are journal articles presenting recent studies and interests. Some are controversial. It was as a separate volume of the Royal Astronomical Society's Geophysical Journal that the papers were first published. Sir Harold is doubtless pleased that of five papers in the section concerning the gravitational field, three specifically deal with artificial satellites—a four-year-old subject that is indicative of the growth which geophysics is undergoing. Perhaps items concerning data analysis and statistical methods are the most obvious omission from the papers of Jeffrey's interests. The short appreciation of Sir Harold by R. Stoneley and the editor's preface should be read at first encounter. Non-mathematicians should not fear that because some papers need mathematical descriptions for their systems that the volume will be of little service to them. The paper by Birch on the composition of the earth's mantle and the papers on the thermal state and history of the earth might particularly appeal to them. J. C. B.


Every year on June 8th, the globe observes World Brain Tumor Day to raise awareness and educate people about brain cancer, encompassing both noncancerous (benign) and cancerous (malignant) growths. Research in the field of brain cancer plays a vital role in supporting medical professionals. In this context, augmented reality (AR) technology has emerged as a valuable tool, enabling surgeons to visualize underlying structures and offering a cost‐effective and time‐efficient alternative. Our study focuses on the efficient segmentation of brain tumor classes using Magnetic Resonance Imaging (MRI) and incorporates a three‐stage approach: preprocessing, segmentation, and 3D reconstruction & AR display. In the preprocessing stage, a Gaussian filter is applied to mitigate intensity heterogeneity. Segmentation and detection are achieved using active geometric contour models, complemented by morphological operations. To establish 3D brain tumor reconstruction, a genuine scene is virtually integrated using 3D Slicer software. The proposed methodology was validated using a genuine patient dataset comprising 496 MRI scans obtained from the local Bab El Oued university hospital center. The results demonstrate the effectiveness of our approach in achieving accurate 3D brain tumor reconstruction, efficient tumor extraction, and augmented reality visualization. The obtained segmentation results showcased an impressive accuracy of 98.61%, outperforming existing state‐of‐the‐art methods and affirming the efficacy of our proposed strategy.


: According to student needs, learning can be supported and enhanced through structured and personalized instruction. This paper presents an approach to personalized pedagogical recommendations based on the student's cognitive profile, given by the Revised Approaches to Studying Inventory (RASI). The recommended pedagogical actions follow the hierarchy of Revised Bloom's Taxonomy. We model the sequencing of pedagogical actions as a multi-objective optimization problem. This problem solution was implemented using a Particle Swarm Optimization (PSO) algorithm. The optimized objectives in this problem are the similarity between the student's profile and the sequence of actions, and the number of actions appropriate to the student's profile. Experiments conducted with students in higher education institutions suggest that the proposed approach using PSO presents solutions that are better accepted by students than the randomized pedagogical recommendation.


At its C terminus, the collagen IV molecule bears a globular NC1 domain, to which two functions have been assigned. In the macromolecular network of collagen IV, two molecules are connected via their NC1 domains, which form a hexameric complex, stabilized by intermolecular disulfide bonds. In addition, the NC1 domains are thought to be responsible for chain selection and assembly. In order to understand the role of the NC1 domains during these steps, hexameric complexes were isolated and further investigated. SDS-polyacrylamide gel electrophoresis and Western blot revealed disulfide-linked α1(IV)NC1 and α2(IV)NC1 homodimers but no heterodimers. The hexamers were dissociated at low pH, separated into monomers and dimers, and submitted to reconstitution experiments. Only α1(IV)NC1 dimers were able to reconstitute a hexameric complex. α1(IV)NC1 and α2(IV)NC1 monomers as well as the α2(IV)NC1 dimers showed only a low tendency to form complexes. It is assumed that during formation of the collagen IV network, lateral aggregation of the molecules via the triple helical domains brings the C termini of two molecules into close vicinity and that subsequently the weak interactions observed between the NC1 subdomains provide the correct alignment for a disulfide exchange. It is, however, questionable whether the low affinity between the NC1 subdomains alone is sufficient for chain assembly and alignment of the α(IV) chains before molecule formation.


e16501 Background: Diabetes mellitus (DM) has been associated with increased incidence and poor prognosis of several cancers such as colon, liver, and breast cancer. However, the impact of DM on su...


The preparation and properties of sodium carbonate and sodium hydroxide-catalyzed phenolic resins polymerized in 1-liter glass reactors over a broad range of F/P mole ratios are described. Laminates produced from selected sodium carbonate-catalyzed resins coated on kraft paper are discussed and compared with laminates prepared from standard sodium hydroxide-catalyzed resins. Several apparent advantages of the sodium carbonate-catalyzed resin systems over the sodium hydroxide-catalyzed resins are presented. The superior performance is attributed to the high degree of crosslinking resulting from the high concentration of methylolated phenols present in the sodium carbonate-catalyzed resin.


Elucidating the astonishing properties of the atomic nucleus remains a formidable challenge for fundamental physics. The Nuclear Structure group of the CSNSM employs a rich variety of experimental techniques in order to probe these different properties, including precision mass spectrometry to obtain nuclear binding energies, decay spectroscopy for the ordering and positioning of the nuclear quantum states, and orientation methods for measuring nuclear moments and angular momentum. This work is carried out within international collaborations at various accelerator facilities in Europe and abroad, with theoretical studies that complement and enrich the results brought via experiment. The group continues the development of techniques and of defining the physics program for the SPIRAL2 project at GANIL in Caen (France).


This paper tries to answer the question which phonetic parameters are particularly responsible for the sound of German. In particular, the accent-rhythmic structures are discussed. In doing so, we reflect on which factors also shape attitudes and perception of German.


The Discrete Element Method (DEM) has been widely used in granular material researches. Especially, if material has a large deformation, such as ground, it can be a useful method to analyze. In this study, to simulate ground formations, DEM was used. The main purpose of DEM analysis was to investigate the numerical model which can predict the TBM performance by simulating excavating procedure. The selected EPB TBM has a 7.73 m of diameter and six spokes. And two pre-defined excavation conditions with the different rotation speeds per minute (RPM) of the cutterhead was applied. In the modeled cutterhead, the open ratio of cutterhead was 21.31% and number of cutters (including disc cutter and cutter bit) was 219. From the results, reaction forces and resistant torques at the cutterhead face and cutting tools, were measured and compared. Additionally the muck discharge rate and accumulated muck discharge by the screw auger were evaluated.


Two cases of retroperitoneal leiomyosarcoma resedted completely are reported. Case 1: A 56-year-old man was admitted to the hospital because of a hard mass with the size of 7.9×7.3×4.1cm in the right lower abdomen. There was no evidence of invading the digestive or urinary tract at preoperative evaluation. The tumor was resected completely from the posterior peritoneal cavity without combined resection. Case 2: A 55-year-old man was admitted to the hospital because of a hard mass with the size of 12.5×11.7×8.3cm in the right lower abdomen, compressing the right external iliac artery and vein. In this case, the lesion was resected completely with right external iliac vein. The vein was reconstructed with a Goretex graft. These two tumors were diagnosed as leiomyosarcoma by the findings of parisading, nuclear atypism, excessive mitosis, and positive staining for α-actin, histologically. The patients are free from any signs of recurrence as of 52 and 11 months after the surgery, in case 1 and 2, respectively. Retroperitoneal leiomyosarcoma is a rare entity. Many cases have had hematogenous metastasis when the primary lesions are detected, with resultant poor prognosis. On the other hand, local recurrence frequently occurs after resection of primary lesion in cases without metastasis. Complete resection is mandatory to improve the prognosis and in these cases without metastasis, complete resection of the primary lesion contributes to good prognosis.


A Tunable Mid-IR light source base Difference Frequency Generation is experimentally investigated. The system tunes 500 nm, ranging from 2.9 µm to 3.4 µm with mW's of output power over the entire range.


Evaluative practices within vis research are not routinely compared to those of psychology, sociology, or other areas of empirical study, leaving vis vulnerable to the replicability crisis that has embroiled scientific research more generally. In this position paper, we compare contemporary vis evaluative practices against those in those other disciplines, and make concrete recommendations as to how vis evaluative practice can be improved through the use of quantitative, qualitative, and mixed research methods. We summarize our discussion and recommendations as a checklist, that we intend to be used a resource for vis researchers conducting evaluative studies, and for reviewers evaluating the merits of such studies.


A data warehouse provides a customer with information to run and plan their business. It is true that if the data warehouse cannot quickly adapt to changes in the environment then the company will lose the advantage that information provides. A warehouse must be built with a solid foundation that is flexible and responsive to business changes. The purpose of the paper is to share experiences in the area of managing the growth within the data warehouse. There are many technical issues that need to be addressed as the data warehouse grows in multiple dimensions. The ideas in this paper should enable you to provide the correct foundation for a long term warehouse. Very few companies are discussing these issues and the lack of discussion leads to a lack of knowledge that will further lead to poor architectural choices. The paper articulates not only the benefits that are derived from data warehousing today but how to prepare to reap benefits for many tomorrow's. It also explores the questions to ask, the points to make, and the issues to be addressed to have a long term successful data warehouse project.


The paper describes a game for teachers, aimed to support them in the design of collaborative learning activities for their students. The game features different dimensions of smartness. It is flexible as it can support training in various contexts and meet different training needs. Moreover, it can be played in 3 different versions: a paper version, a digital version and a hybrid/augmented version. The game was used in the context of a teacher training initiative and preliminary evaluation data were collected after the game sessions. These initial data confirm the game flexibility and capacity to adapt to different contexts and reveal that teachers appreciated the game, especially its tangible component.


Major depressive disorder is a mood disorder that affects millions of people each year, in many cases leading to disability or even suicide. Its symptoms, as outlined in the DSM-5, include low mood, fatigue, loss of pleasure in previously enjoyable activities, difficulty sleeping or eating normally, trouble concentrating, and thoughts of death or suicide. These symptoms have been described in many forms throughout history, dating back at least to the time of Hippocrates (460–370 BC) and the ancient Greek diagnosis of melancholia. Modern clinicians and researchers have proposed a variety of cognitive, biological, and social/environmental theories to explain the cause of major depressive disorder. The disorder is commonly assessed via clinical interview and/or self-report questionnaires. First-line treatments for major depressive disorder include psychotherapy and antidepressant medications.

Keywords:

psychopathology;
psychotherapies;
depression


We present new, high-resolution observations of the interstellar medium (ISM) in the two dwarf elliptical galaxies NGC 185 and NGC 205, as well as a new upper limit on the H I content of the dwarf elliptical galaxy NGC 147. The data consist of VLA observations of H I emission at ~80 pc resolution (a factor of 3.5 improvement over older data), CO spectra at ~80 pc resolution in NGC 185 and NGC 205, an image of CO emission in NGC 205 at 40 × 20 pc resolution from the BIMA array, and Hα images of NGC 185 and NGC 205. These observations represent the intersection of two separate fields of inquiry: (1) the distribution, kinematics, and origin of neutral gas in giant ellipticals, which are structurally similar to the dwarf ellipticals but cannot currently be studied at such high linear resolution; and (2) the physical properties of the ISM in the Galaxy and its neighbors, which can be studied at very high linear resolution but which might have very different interstellar media than elliptical galaxies. The new H I images show that the neutral gas and stars of NGC 205 are two distinct dynamical systems, whereas in NGC 185 the gas and stars may be parts of the same dynamical system. The H I distributions in these galaxies are less extended than the optical emission and do not appear to be stable rotating disks, a result that is very different from the pattern established for giant ellipticals. An internal gas origin (mass loss from evolved stars) may be plausible for NGC 185. No H I emission is detected in NGC 147 with an upper limit of 3 × 103 M☉ for an unresolved source with a line width of 8 km s-1. Furthermore, the H I distributions in NGC 185 and 205 are extremely clumpy on size and mass scales less than 200 pc and ~104 M☉, with H I velocity dispersions ranging from 3 to 15 km s-1. We present evidence that the molecular gas in these galaxies is associated with individual clumps or clouds of atomic gas, similar to many Galactic giant molecular clouds. However, the H I column densities in the dwarf ellipticals are factors of 5-10 less than the 1021 cm-2 thought to be necessary to shield Galactic giant molecular clouds against photodissociation. Images of NGC 185 in Hα + [N II] show an extended region of emission 50 pc in diameter near the center of the galaxy and the H I column density peak.


The purpose of the present study is to investigate the effect of cortical bone on acoustic properties of trabecular bone, such as speed of sound (SOS) and normalized broadband ultrasound attenuation (nBUA), in bovine femur in vitro. Twelve trabecular bone samples and three cortical bone plates with thicknesses of 1.00, 1.47, and 2.00 mm were extracted from the proximal end of two bovine femurs. The correlations between acoustic properties and trabecular apparent bone density were also examined before and after attaching a cortical bone plate to the trabecular bone samples. SOS increased linearly with increasing thickness of the cortical plate attached to one side of ultrasonic incidence of the trabecular bone samples, whereas nBUA showed a nonlinear dependence on the thickness of the cortical plate. All the SOS (r


8525 Background: CDX-011 is an ADC consisting of the potent cellular toxin MMAE conjugated to a fully human monoclonal antibody (CR011) to GPNMB, a novel glycoprotein frequently expressed in melanoma. CDX-011 potently inhibits the growth of a variety of melanoma cell lines in vitro and shows significant antitumor activity in melanoma xenograft mouse models. Methods: This phase I/II study in patients with unresectable, stage III/IV melanoma evaluated CDX-011, given once every 3 weeks (q3w), in a standard 3+3 dose-escalation (DE) and a phase II expansion at the maximum tolerated dose (MTD) with primary activity endpoint of overall response rate (ORR) (P0 = ≤5%; P1 = ≥20%; α = β = 0.10). Subsequently, more frequent dosing schedules (once weekly for two of three weeks [q2/3w] and weekly [qw]) were evaluated. Results: Enrollment is complete (n = 117; male = 64%; median age = 62y; stage IV = 89%; M1c = 50%). For q3w, q2/3w, and qw schedules, respectively, MTDs were 1.88, 1.5, and 1.0 mg/kg. At the MTDs, the mos...