This article aims to: (1) identify the grammatical and lexical aspects of the novel "A Pair of White Angsa For Palupi", and (2) describe the grammatical and lexical aspects of the novel "Sepair of white swans for Palupi". The study used a qualitative approach with a qualitative descriptive method. The technique used in this article is the documentation, listen and note technique. Data collection is done by using data source analysis. The researcher became the main data collection tool and at the same time directly analyzed the collected data. The results showed that there were five data that included grammatical and lexical aspects, which included: First, there were twenty grammatical data in the form of grammatical cohesion markers that appeared, namely references, substitutions, conjunctions, and ellipsis. Second, there are five lexical data in the form of lexical cohesion that appears, namely repetition, antonym. The results of the study indicate that there are grammatical and lexical aspects of the discourse of the novel "A Pair of White Swans for Palupi". Based on the research that has been done, the suggestion to be conveyed to the author is to be careful in the use of pronouns because the use of pronouns that are not appropriate or appropriate can give different or ambiguous meanings. The next suggestion is, it is hoped that there will be further research on grammatical and lexical cohesion.[1] Mahasiswa Program Studi Pendidikan Bahasa dan Sastra Indonesia, Fakultas Keguruan dan Ilmu Pendidikan, Universitas Muhammadiyah Surakarta[2] Dosen Program Studi Pendidikan Bahasa dan Sastra Indonesia, Fakultas Keguruan dan Ilmu Pendidikan, Universitas Muhammadiyah Surakarta


The present study aimed to investigate the relationships between WTC in English in classroom context and four trait-like variables: L2 confidence, L2 motivation, L2 anxiety and grit, to propose a WTC model in EFL classroom setting in Iran, and to identify the best predicting variable of WTC in English. The participants were 488 non-English majored university students in two public and two private universities in Iran. The research instrument used in this study was an online questionnaire. The structural equation modeling (SEM) using Amos was conducted to analyze the data. The key findings are as follows. First, positive relationships were found between WTC in English and L2 confidence, L2 motivation, and grit and a negative relationship was found between WTC in English and L2 anxiety. Second, based on the finalized model, L2 confidence, L2 motivation, and L2 anxiety are the predicting variables of WTC in English in Iranian EFL classroom settings whereas grit serves as a mediator through L2 motivation and L2 anxiety. Lastly, L2 motivation was found to be the best predicting variable for WTC in English. In order to enhance the willingness to communicate in English with university students in Iran, English teachers are recommended to design their lessons to help students enhance and maintain L2 motivation, build L2 confidence, reduce L2 anxiety and develop grit.


Abstract Zeigler's device, "How do you rate yourself recreationally," was used to classify 103 male and 104 female students into four categories: recreationally outstanding, above average, average, and below average. California Inventory (CPl) was administered to all subjects. Analyses of variance were conducted to find out if significant differences existed among the four groups of men and the four groups of women. The two groups were reclassified according to type of activity or cluster of activities preferred: physical, social, communicative, aesthetic, and learnings; and another set of analyses of variances was conducted among these new groups. Although the F tests revealed that there were significant differences in some, but not all, of the traits of personality among the groups, it was concluded that the evidence is not strong enough to indicate that there are differences between the personalities of those who are recreationally inclined and those who are not recreationally inclined. Also, it was co...


The most important meteorological effects on sound propagation are refraction‐ground attenuation, atmospheric absorption, and scattering by turbulence. The wind and temperature gradients cause refraction of the sound rays, and hence influence the sound level. The curvature of a nearly horizontal sound ray can be calculated by using measurements of wind and temperature. Atmospheric absorption is important for outdoor sound propagation. The absorption varies for different parts of the world. Results from some stations in Scandinavia are given. Atmospheric absorption for the high frequencies changes during different times of the year. The absorption for low frequencies varies both over the day and the year. The size of the annual and diurnal variance is frequency dependent. An increase in the accuracy of calculations of outdoor sound levels can be made by considering the local climate. The values of atmospheric absorption need to be calculated for the local climate instead of using some global mean value. Th...


In a stylized model, firms differentiate their products to escape import com- petition. Facing a nested CES demand, each firm chooses between a nest with competitors and its own nest under higher costs. The profit from differentiation is an inverted U-shaped function of firm productivity. It increases with import competition and is lower than the social benefit. Differentiation increases the gains from trade. In establishment data from China spanning its 2001 WTO accession, tariff cuts are associated with increases in productivity, introduction of new goods, switches to skill-intensive sectors. Markups in the model explain the large increases in revenue productivity among small firms and input suppliers.


Properties and local structures of RE2O3-Al2O3-SiO2 (RE=Y, Lu) glasses probed by molecular dynamics simulations and solid-state NMR : The role of aluminium and rare-earth ions


The electronic version of Vice President Gore's speech from Paul Evans Peters of the Coalition for Networked Information, who in his message acknowledged Robert Bryan Reinhart for bringing this version of the speech to his attention.


Electroluminescent intensity and external quantum efficiency (EQE) in ultraviolet organic light‐emitting diodes (UV OLEDs) have been remarkably enhanced by using a graded hole‐injection and ‐transporting (HIT) structure of MoO3/N,N ′‐bis(naphthalen‐1‐yl)‐N,N ′‐bis(phenyl)‐benzidine/MoO3/4,4′‐bis(carbazol‐9‐yl)biphenyl (CBP). The graded‐HIT based UV OLED shows superior short‐wavelength emis‐ sion with spectral peak of ∼410 nm, maximum electroluminescent intensity of 2.2 mW/cm2 at 215 mA/cm2 and an EQE of 0.72% at 5.5 mA/cm2. Impedance spectroscopy is employed to clarify the enhanced hole‐injection and ‐transporting capacity of the graded‐HIT structure. Our results provide a simple and effective approach for constructing efficient UV OLEDs. (© 2015 WILEY‐VCH Verlag GmbH &Co. KGaA, Weinheim)


We present sympathetic cooling in an optomechanical system consisting of two coupled cantilevers. The hybridization of the cantilevers creates a symmetric mode, which is feedback cooled, and an anti-symmetric mode not directly controllable by the feedback. The scheme of sympathetic cooling is adopted to cool the anti-symmetric mode indirectly by parametrically coupling to the feedback-cooled symmetric mode, from which the cooling power can be transferred. Experiment shows that the realization of coherent dynamics plays an essential role in sympathetic cooling, in which optimal cooling is achieved when the mechanical dissipation rate and the strength of coupling become comparable. The sympathetic cooling is improved by increasing the strength of mode coupling to enhance the transfer of cooling power. Also, the limit of sympathetic cooling imposed by the capacity of feedback cooling is reached as the effective temperatures of the two modes approach the strong coherent coupling condition. Our research provides the prospect of extending the cooling techniques to coupled mechanical resonators for a broad application in sensing and information processing.


ABSTRACT This investigation deals with paraffinic hydrocarbons in crude oil using gas chromatography/mass spectroscopy. The study indicates that Qaiyarah paraffinic hydrocarbons, identified in the naphtha fraction, could be a major contributor and good feedstock in the petrochemical industry.


= 0.9315; P < 0.001). A progressive decrease in pregnancy rate with lengthening search times was also observed (41.2, 36.6, 26.8, and 21.2%, respectively; R 2 = 0.9812; P < 0.0001). Pregnancy loss rates were comparable between all the extended search groups and control. Conclusion: It appears that the length of time required to extensively search a testicular tissue sample, to ICSI inseminate all the oocyte cohorts, is inversely related to fertilization and pregnancy outcomes. In spite of the timedependent clinical performance, searching for precious spermatozoa is still warranted even after several hours of hunting. Though labor-intensive and time-consuming, this procedure still grants many couples the opportunity to conceive.


Different consequences concerning the cardiac function and structure in patients with renal artery stenosis (RAS) and completely different patterns of activation of the renin-angiotensin-aldosteron system were reported, depending on RAS severity. These changes might have an impact upon the outcomes after renal revascularization.

 The study was aimed to analyze the effect of renal stenting upon echocardiographic parameters of cardiac structure and function in the studied population and by comparison between 3 different RAS-profile patients.

 A total of 78 hypertensive patients diagnosed by renal angiography with significant RAS (>70%) were prospectively enrolled, thus subsequently resulting in 3 groups (34-unilateral RAS, 28-bilateral RAS, 14-RAS in a solitary kidney). Clinical, laboratory and echocardiographic parameters (left ventricular (LV) dimensions, LV mass index (LVMI), relative wall thickness (RWT), type of cardiac geometry, systolic and diastolic function, LV filling pressures) were assessed before renal stenting and 12 months after the procedure. The evolution of renal function was based on the glomerular filtration rate (eGFRCKD-EPI). Blood pressure evolution after revascularization was defined as cured, controlled, improved or stationary.

 Similar baseline characteristics were found for the 3 study groups regarding demographics, cardiovascular risk factors, baseline LV diameters, RWT and LVMI (p>0.05), although higher values of echocardiographic parameters were observed in solitary kidney RAS patients. Only 9.6% of all cases had normal geometry, the majority of the patients presenting concentric hypertrophy (58.9%) of similar proportions in the defined groups. Analyzing variations of echocardiographic parameters before and 12 months after stenting confirmed significant changes in all structural parameters (LV walls dimensions, LVMI, RWT, p<0.05), with significant differences between the 3 study groups. The most favorable evolution after revascularization was observed in bilateral-RAS patients (significant decreased cardiac mass, p=0.018), while RAS in a solitary kidney was associated with non-significant changes of the analyzed parameters. The evaluation of cardiac geometry evolution 12 month after renal stenting showed a stationary cardiac remodeling profile (p>0.05).

 The current analysis showed favorable outcomes after renal angioplasty with stent in RAS patients with regard to structural changes of the LV (regression of LVMI, RWT). However, the impact of these beneficial changes did not have the magnitude for producing a significant effect upon cardiac geometry one year after renal revascularization.


Provided are a method for manufacturing a chromatography for molecular recognition, a chromatography column obtained by the method which can selectively isolate functional components with high purity from natural material, and a method for isolating ferulic acid using the chromatography column. The method for manufacturing the chromatography comprises the steps of (i) mixing a template molecule(desired material), a vinyl monomer which recognizes the template molecule by specific linkage, and crosslinking agent in solvent, (ii) irradiating the mixture solution to form a high molecular matrix by radical polymerization, (iii) crushing and screening the high molecular matrix, (iv) filling a chromatography column with the screened high molecular matrix, and (v) injecting the solvent for isolation of the template molecule into the column, so as to isolate the template molecule.


Generalized ligamentous laxity and AP laxity at the knee are associated with ACL tears and may explain part of the gender disparity in injury occurrence.


The thesis deals with the optimalization of tax liability in natural person. It is divided into two parts, theoretical and practical part. In terms of the theoretical part, the reference books' data related to income tax of a natural person. Practical part of this thesis is focused on the calculation of income tax of the chosen subject and at the end the optimization for the chosen subject is propřed, this includes calculation of health and social insurance.


A level set formulation of Eulerian interface capturing methods is applied to analyze an interface motion in incompressible gas-liquid two-phase flow. The Navier-Stokes equations in primitive variable formulations are solved on a staggered grid by the method of lines. The advection terms are discretized by QUICK method and the other terms by central finite difference method except for the body force, and a second-order Adams-Bashforth method is used as the time integration scheme. The Poisson equation is solved by means of the Successive Over Relaxation (SOR) approach. The model of Continuum Surface Force (CSF), which interprets surface tension as a continuous effects across an interface rather than as a boundary condition on the interface, is employed to treat the surface tension at the interface. Numerical results are obtained for an oscillation of droplet driven by surface tension at high Reynolds number (1000), head-on collision of two water droplets with large density ratio (1000/1), falling of a water droplet with large density ratio (1000/1), and dam-breaking in the air. It is comfirmed that the present approach is efficient as well as robust and is suitable for numerical solutions to incompressible gas-liquid two-phase flow.


A conception of the virtual reality system suited to binocular stereo vision and possible for precise three dimensional measuring are proposed.The application requirements,the theory principles and the construction technologies about this system are presented in this paper.Some methods based on aerophotogrammetry and close-range photogrammetry,UAV low altitude photography,Insar and Sonar principles are proposed for three dimensional modeling data acquisition Binocular perspective projection algorithm is adopted to transfer three dimensional model into binocular images.Then stereovision equipment produces binocular stereovision according to the geometric and physical principle.Finally some tested application examples are listed.


Three-dimensional linear secondary instability theory is extended for compressible and high-Mach-number boundary-layer flows. The effect of a small- but finite-amplitude compressible Tollmien-Schlichting wave on the growth of dimensional perturbations is investigated. The focus is on principal parametric resonance responsible for the strong growth of subharmonics in a low-disturbance environnement. The effect of increasing number on the onset, growth, and shape of eigenfunctions of the subharmonics is assessed, and the resulting vortical structure is examined.


The paper describes a fesibility study carried out for the Employment Service and the Department for Education and Employment in Britain to identify those individuals who, when first registering as umemployed, are likely to be at high rish of becoming long-term unemployed. A simple preidction scheme is developed that can be easily administered by officials who deal with unemployment registration. The scheme is based on a logistic model for the odds of long-term employment which is clibrated and cross-validated on the ntional cohort study containing data on employment histories. The paper concludes with discussion of the effects of the decision rules that are chosen and of the prediction errors that arise when the prediction scheme is applied in pratice.


Evaluation of mechanical properties from a small amount of test material is essential in a process of development of new alloys and monitoring of degradation and damage of in-service components. Miniaturization of test specimen together with a specimen reconstitution technique enable direct method of evaluation of mechanical properties if only a limited amount of material is available. Modern types of construction steels and alloys possess improved metallurgical and mechanical properties and also demonstrate a high level of fracture toughness. In these cases, correlation and correction of size effect on fracture toughness between different specimen sizes are needed. Within this contribution the size effect of J-R curve for two sizes of three-point-bend specimens is solved. The J-R curves of three-point-bend specimens with cross-section 10 × 10 mm and 3 × 4 mm of P91 and Eurofer97 steel were determined at room temperature. The existence of size effect is proven as larger specimens demonstrate higher J-R curves than smaller specimens for both steels. Simplified mechanical model based on fracture energies initially proposed by Schindler et al. is applied to describe experimentally determined J-R curves and to predict the observed size effect between used specimen sizes.


Recent years in major international sport events China has achieved remarkable results.Preparing for this event with a large number of systemic technology services is inseparable.Large-scale event is an innovative technology services practice."Large" refers to the giant system with complex system structure.Integrated innovation is the innovative activity approach of the complex giant system.Then there is a new topic of sports science,that is,how to integrate the innovative practice efficiency in certain time and space and scientific services to have practical effect,how to greatly use the scientific achievement in the real game and help the players achieve good performance.


National borders play an important role in everyday life. Interest in border studies has increased with recent changes in geographical locations of the border or the fluctuation of the permeability of the border between some countries, such as in the European Union. Whether the nations are trying to increase traffic flow of the border or to implement stricter border control, having appropriate information of the border is crucial for effective policymaking. The objective of this research was to identify areas of high porosity, or high permeability, for pedestrians along the southern national border region in Carinthia, Austria using terrain, land use, and road data along with geocomputational methods. Two unsupervised classification methods, the fuzzy K-means clustering and the Self-Organizing Map, were applied to segment the border into homogeneous zones according to topographic and infrastructural attributes. The fuzzy K-means clustering method was chosen for its ability to allow for a continuous approach to classification. With this method, an object can belong, with different degrees of membership, to multiple classes, which is a more realistic reflection of the natural world than discrete clustering, where each object can only belong to one class. However, the fuzzy K-means clustering method does have disadvantages, i.e. the user must determine the number of classes and the input parameters are required to be in continuous format. The second classification method, the Self-Organizing Map, is a type of artificial neural network and was chosen for its ability to automatically determine the number of classes and handle categorical data. The Self-Organizing Map is unique because it can transform high dimensional data into low dimensional display while preserving the topology and spatial distribution of the input parameters. The results of the two classification methods suggest that the fuzzy K-means classification is more effective than the Self-Organizing Map for this situation. However, more research is needed to determine the fit of these algorithms for particular spatial data classification tasks. The results obtained from this research provide an insight into the permeability of the border region of Carinthia, Slovenia, and Italy to pedestrian traffic and can be potentially useful for decision making processes for tourism development and road transportation management in that region. Furthermore, the approach presented in this article can be applied to other national borders to identify zones permeable to pedestrian traffic.


Diabetes mellitus is now a major cause of chronic kidney disease with a prevalence of 11% to 83.7% in Africa. The presence of drug-induced hypoglycemia further increases the risk of death by 2-3 folds; a risk that is further heightened by the presence of nephropathy of which many diabetics are unaware due to poor screening practice by health workers in diabetes clinics. Sufficient data also exist to show that many diabetics have poor knowledge about harmful effects of anti-diabetic agents. We conducted electronic search of literature using various search engines such as MEDLINE, pub med, research gate, google scholar, cross-ref etc using keywords such as 'nephropathy, diabetes, hypoglycemia, renal failure, iatrogenic, anti-diabetic agents'. We then identified the case of a 60 year old diabetic with subclinical undiagnosed severe chronic kidney disease (NKF-KDOQI stage 5) who presented to our Emergency Unit with hypoglycemic coma after he self-medicated on 5mg glibenclamide daily over 72 hours. Our review relates poor knowledge of diabetes and renal failure among diabetics and physicians to the danger of recurrent of hypoglycemia and increased risks of mortality. We conclude that diabetes clinics need to be properly structured to include special rooms for practiceoriented interactive sessions and audio-visual presentations; we suggest running multiple diabetes clinics in settings where the patient load is enormous; dieticians and trained Diabetes Health Educators should be integrated into the diabetes out-patient clinics.


In their insightful and constructive review, "Death, Disability, and Dogma," Jennifer Clegg and Richard Lansdall-Welfare manage to create the very dialogue that they argue is lacking. Their contention is that the lack of dialogue between different realms of discourse has led to rigid service response by caregivers that attempt to address losses experienced by individuals with intellectual disabilities. They argue that this situation arises because of the complexity of the cultural meaning of death and the uncertainty of the meaning for individuals with intellectual disabilities. Their essay, in itself, is powerfully cross-disciplinary. They review the concept of bereavement from different perspectives: social science research, psychiatric practice, and underlying cultural meanings. This review indicates that social science research has moved from attempting to develop definitive statements about the meaning of death. From their review, it is possible to discern that there may have been an underlying positivist orientation that assumed that a univocal meaning to the loss experience can be discovered. But the only universal fact about death is that there is a loss. It is a significant life event. Going all the way back to the early work of Holmes and Rahe (1967), it is clear that the impact and meaning of the same life event varies from individual to individual. There are multiple layers of meaning that include at least one's larger culture, subgroup values, family meaning, and finally individual interpretation. Clegg and Landsdall-Welfare see the current findings of social science as pointing to the need to be sensitive to the meaning of the death event for the specific individual. It appears to be inappropriate to impose normative stages onto an individual's grief experience. The finding from the review of psychiatric investigation of loss experiences is that bereavement can contribute to health problems. The loss experience is not necessarily pathologic. This compares to the acknowledgement that depression and anxiety are not necessarily illnesses to be treated, but basic human coping mechanisms that can become problematic. Similarly, the loss experience can be a traumatic experience with negative health implications. Clegg and Landsdall-Welfare acknowledge the limited nature of their review of the role of culture in the meaning of the loss experience. But even so, it is clear that the larger cultural context contributes critically to the individual's experience of loss. Oversimplification and reductionistic approaches to the death experience result in insensitive, stereotypic, formulaic, and consequently unsuccessful intervention strategies. The problem, as Clegg and Landsdall-Welfare see it, is that these discoveries and insights have not been effectively integrated into the discourse about and interventions for loss experiences for individuals with intellectual disability. This failure has occurred because of the strong continued


The main point of this work is to explain the current status of nuclear power and safety level in the early 21st century. Another point deals with the use of nuclear energy and nuclear non-proliferation. Other points deal with the existence of nuclear power plants from beginning to the present with the prospects for the future. In conclusion are rated nuclear accidents, safety and security of power plants. In annex of work are illustrative animations showing operations of the most common nuclear reactors.


T: 37.2 P: 84 R: 18 BP: 180/110 ♦ Risk for prone behavior related to lack of knowledge about the disease ♦ High blood pressure (HBP) or hypertension means high pressure (tension) in the arteries. Arteries are vessels that carry blood from the pumping heart to all the tissues and organs of the body. High blood pressure does not mean excessive emotional tension, although emotional tension and stress can temporarily increase blood pressure. Normal blood pressure is below 120/80; blood pressure between 120/80 and 139/89 is called "prehypertension", ♦ After 8 hours of nursing interventions, the patient will verbalize understanding of the disease process and treatment regimen. INDEPENDENT: ♦ Define and state the limits of desired BP. Explain hypertension and its effect on the heart, blood vessels, kidney, and brain.


ABSTRACT This systematic review evaluates the effect of exercise on pediatric chronic pain in: (a) pre-post-test comparisons and RCTs, and (b) longitudinal actigraphy studies in children's free-living environments. Following the PRISMA guidelines, 15 studies met inclusion criteria. Although preliminary results suggest exercise may be related to decreased pain, the overall effect of exercise on chronic pain remains inconclusive due to low methodological quality and high risk of bias. Therefore, results underscore the need for future RCTs that examine aerobic exercise and chronic pain. Further, increased sample sizes would allow for future examinations of moderators or indirect paths between exercise and pain.


Determining translation quality requires a precise measure of the traits being examined. This article evaluates a new framework for translation quality evaluation, Multidimensional Quality Metrics (MQM), to the task of grading student translations. It demonstrates the viability (i.e. the practicality, validity and reliability) of using the MQM framework by novice raters to judge translations based on the American Translators Association's translator certification exam grading system. The data gathered for this study were drawn from 29 student translations of a single news story that were rated by nine novice and two expert raters. The study used average time on task, correlations between novices and experts and Many-Facet Rasch Measurement to identify the extent to which this use of the MQM framework was viable. The findings indicate that this implementation of MQM can be viable with novice raters under the right conditions.


Newtonian fluid flow in a duct has been studied extensively, and velocity profiles for both laminar and turbulent flows can be found in countless references. Non-Newtonian fluids have also been studied extensively, however, but are not given the same attention in the Mechanical Engineering curriculum. Because of a perceived need for the study of such fluids, data were collected and analyzed for various common non-Newtonian fluids in order to make the topic more compelling for study. The viscosity and apparent viscosity of non-Newtonian fluids are both defined in this paper. A comparison is made between these fluids and Newtonian fluids. Velocity profiles for Newtonian and non-Newtonian fluid flow in a circular duct are described and sketched. Included are profiles for dilatant, pseudoplastic and Bingham fluids. Only laminar flow is considered, because the differences for turbulent flow are less distinct. Also included is a procedure for determining the laminar flow friction factor which allows for calculating pressure drop. The laminar flow friction factor in classical non-Newtonian fluid studies is the Fanning friction factor. The equations developed in this study involve the Darcy-Weisbach friction factor which is preferred for Newtonian fluids. Also presented in this paper are viscosity data of Heinz Ketchup, Kroger Honey, Jif Creamy Peanut Butter, and Kraft Mayonnaise. These data were obtained with a TA viscometer. The results of this study will thus provide the student with the following for non-Newtonian fluids: • Viscosity data and how it is measured for several common non-Newtonian fluids; • A knowledge of velocity profiles for laminar flow in a circular duct for both Newtonian and non-Newtonian fluids; • A procedure for determining friction factor and calculating pressure drop for non-Newtonian flow in a duct.Copyright © 2008 by ASME


This paper addresses the filtering for discrete-time Markovian jump singular systems (MJSSs). While the existing researches have only given the sufficient conditions, in this paper a sufficient and necessary condition is established to guarantee that the filtering error system is regular, causal, stochastically stable and performance in light of supermartingale-liked approach and property of conditional expectation as well as – bounded real lemma. For obtaining the filter, an equivalent matrix inequality to the obtained one in nonlinear form is provided in terms of congruence transformation. Thus the desired filter can be developed by choosing matrix variables with certain structures. Finally, two simulations are provided to show the effectiveness of the proposed techniques in this paper.


Aim:To investigate the effect of Arg/Pro polymorphism of p53 within codon 72 in exon 4,smoking,and their combined effect on the occurrence of lung cancer in Henan Han population.Methods:Arg/Pro polymorphism of p53 and smoking states were compared among 124 patients with lung cancer and 128 normal controls.Arg/Pro polymorphism was detected by PCR-RFLP.Results:Frequencies of Pro/Pro genotype were 15.6% in controls and 28.2% in cases,respectively;compared with Arg/Arg and Arg/Pro genotype,Pro/Pro genotype increased the risk of lung cancer and the adjusted OR(95%CI) was 2.11(1.12~3.97).Compared with non-Pro/Pro genotype and non-smoking,the adjusted OR(95%CI) of Pro/Pro genotype and smoking was 0.93(0.36~2.38) and 2.27(1.13~4.54),respectively.For the individuals with smoking and Pro/Pro genotype,the adjusted OR(95%CI) was 10.49(3.42~32.23).Interaction between smoking and Pro/Pro genotype was observed (χ2=5.209,P=0.023).Conclusion:Smoking,p53 Pro/Pro genotype and their interaction may contribute to the occurrence of lung cancer in Henan Han population.


President and CEO Crystal Cove Alliance Newport Beach CA us Job Crystal Cove Alliance (CCA) seeks a proven executive to design/deliver coastal-oriented education, conservation, recreation experiences, complete in-process capital improvements to preserve historic cottages, and manage a financially su


Dengue infection, an arthropod-borne viral hemorrhagic fever, continues to be a major challenge to public health,
especially in South-East Asia. It has a wide geographical distribution and can present with a diverse clinical spectrum. The
liver dysfunction could be a direct viral effect or an adverse consequence of dysregulated host immune response against the virus. Hepatic
involvement can be characterized by manifestations of acute hepatitis, with pain in the right hypochondrium, hepatomegaly, jaundice, and raised
aminotransferase levels. Several outbreaks of dengue infection have been reported from India. However, large clinical studies documenting
hepatic involvement in dengue infection, especially in adults, are scarce.


This extended abstract describes the concept of DryNights, a bedwetting behaviour change support system concept consisting out of a self-powered sensor and a mobile application developed in collaboration with LifeSense Group (spinoff Imec, Holst Centre) and the Eindhoven University of Technology. The sensor uses the principle of an electrochemical cell to generate its own electricity and to power a harmless and wireless signal transmission from the sensor to a mobile device. The mobile application has been designed in collaboration with children (N=75) from the target group. The reliability of the signal transmission and the range of the sensor have been successfully evaluated in a small scale experiment. Trials with children wearing it to go to sleep are currently under way, and suggest that DryNights is comfortable and children are experiencing it positively.


The 2011 Budget did not hold any great surprises - either good or bad. Finance Minister Pravin Gordhan reiterated government's aim to put development first, and not dependence on welfare. The budget therefore proposes a range of measures and incentives to accelerate employment creation; improve the quality of education; enhance health services; make communities safer; and to promote economic and agricultural development.


This paper presents the test results on a compact, off-axis telescope which is the precursor projector/receiver for a NASA Shuttle-based coherent lidar system operating at a wavelength of 2 microns to measure atmospheric wind profiles. The afocal telescope has an entrance pupil diameter of 25 cm, and an angular magnification of 25x. To determine the transmitted and returned optical wavefront quality, the telescope was tested in a Twyman-Green configuration at the operational wavelength. Interferograms were obtained via an infrared camera, and analyzed using a digitizing tablet and WYKO WISP software. Interferograms were obtained with and without an 11.7 degree wedged silicon window located in the entrance pupil. This window, which rotates orthogonal to the telescope optical axis, serves as the lidar system scanner. The measured wavefront information from the interferometer was used in a GLAD heterodyne receiver model to predict the effect of the optical system on the lidar performance. The experimental setup and procedures will be described, and the measurement results of the coherent lidar optical subsystem will be presented in this paper.


Megan Pham, chief investment officer of AMIST Super, talks through the logic of her fund's asset allocation and manager selection with David Rowley.


Adenohypophyses (AP) of female rats were exposed to 3H-leucine either in vivo or in vitro, then incubated in vitro. The prolactin (PI) in the tissues and incubation medium was separated and quantified by disc electrophoresis (DE) and densitometry. The PI bands were cut from the gel columns and counted by liquid scintillation procedures. In all experiments the specific activity of prolactin (cpm/μg) in the medium became significantly greater than that in the tissue, and was as high as 2.7 times that of the tissue in some cases. This indicated that prolactin was secreted in vitro from more than one pool, with the newly synthesized (labeled) hormone being rapidly released. One rapid turnover pool was indicated by an increase of as much as 100% in medium PI specific activity between 40 and 70 minutes of incubation of AP labeled in vivo one hour before incubation. This early increase did not occur with AP labeled in vivo 4 hours. Another less rapid turnover pool was suggested by a greater discrepancy between m...


Structural hysteresis provides a conceptual framework in which to consider relationships between organization size and structure during periods of decline. The use of this framework, as an extension of current theory, indicates that relationships between size and structure in declining organizations do not parallel those found in growing organizations. Participation problems, commitment, and coalition politics may explain the occurrence of structural hysteresis. Implications for theory and research are discussed.


Objective To investigate whether K+ channel opener diazoxide could protect cells from Aβ1-42-induced cytotoxicity and its molecular mechanism. Methods Neuroglioma U251 cells were exposed to different concentrations of Aβ1-42 and diazoxide for 24 h in vitro. Cellular viabilities were assessed with MTT. The mitochondria membrane potential and intracellular reactive oxygen species (ROS) levels were detected by 5, 5', 6, 6'-tetrachloro-1, 1', 3, 3'-tetraethyl-benzamidazolocarbocyanin iodide (JC-1) and 2', 7'-dichlorodihydrofluorescin diacetate (DCFH-DA) respectively, and cell apoptosis by Annexin-V-FITC/PI fluorescence flow cytometry. Results 1) In different concentration of Aβ1-42 the survival rate of neuroglioma U251 cell (U251 cell) in diazoxide group was significantly higher than that in simple Aβ1-42 group (P 0.05). 2) In semi-quantitative analysis, red/green fluorescence light intensity ratio of mitochondrial membrane (590/527 nm) in simple Aβ1-42 group (5 μmol/L) was significantly lower than that in normal control group (P 0.01) U251 cell red/green fluorescence light intensity ratio in diazoxide group (590/527 nm) was significantly higher than that in simple Aβ1-42 group (P 0.01). 3) Flow cytometry showed that U251 intracellular ROS level in simple Aβ1-42 group (5 μmol/L) was significantly higher than that in control group (P 0.05) after pre-treatment with diazoxide (1 mmol/L), U251 intracellular ROS level decreased significantly comparing with simple Aβ1-42 group (P 0.05). 4) Whether Aβ1-42 or Aβ42-1 did not cause early or later cell apoptosis or necrosis as compared to control in fluorescence flow cytometry. Conclusion The cellular toxic effect of Aβ1-42 occurs earlier than its induction of cell apoptosis. It suggested that earlier diazoxide could protect mitochondrial function and prevent nerve cells decreasing cell induced by cell apoptosis in long-term Aβ1-42 exposure.


Purpose: To investigate the properties of surface-functionalized, hyaluronic acid-coated, cabazitaxelloaded solid lipid nanoparticles (HA-CZ-SLNs) for the treatment of breast cancer. Methods: HA-CZ-SLNs were prepared by a homogenization method. Nanoparticles were designed for prolonged circulation and slow release of the drug, as well as internalization of the nanocarrier into cancer cells. The nanoparticles were evaluated using dynamic light scattering, in vitro drug release, cell cytotoxicity and uptake studies. Results: Transmission electron microscopy revealed the resultant particles to be distinct, discrete, spherical cores surrounded by HA shells with a uniform diameter of ~210 nm. In vitro release of CZ followed a biphasic pattern with sustained release throughout the study period, implying efficient delivery for treatment. Increased cytotoxicity was exerted by HA-CZ-SLNs compared with the free drug. More importantly, HA on the surface of nanoparticles interacted with CD44 receptors overexpressed on cancer cells, resulting in increased internalization in MCF-7 cells. Excess free HA competed with this uptake, indicating that nanoparticle uptake was via receptor-mediated endocytosis. This mechanism is expected to result in enhanced therapeutic efficacy for the treatment of breast cancer. Conclusion: The results indicate prolonged release and enhanced cell penetration, release and cytotoxicity of the drug, thus showing the potential application of the surface-modified nanoparticles for the treatment of breast cancer. Keywords: Cabazitaxel, Breast cancer, Hyaluronic acid, Nanoparticle, Lipid carrier, Receptor-mediated endocytosis


This study analyzes variation in the expressive modes of official religious rhetoric by Mormon leaders during a 150 year span of Mormon history. Rhetorical modes-identified through content analysis of a comprehensive sample of Mormon general conference addresses-include categories of: (1) exposition (i.e., explanation, justification, repudiation, narration), and (2) admonition (i.e., prescription, proscription, chastisement). Findings include: consistent preference for expository rhetoric over admonition; within expository rhetoric, a shift towards more explanation and repudiation but less narration and justification; general predominance ofprescriptive over proscriptive and chastisement rhetorical modes within the category of admonition; but variations in admonitory modes relative to different audiences (e.g., members vs. non-members, men vs. women, adults vs. youth). The theoretical and historical implications of these findings are discussed in relationship to the social transformation of Mormonism from its initial cult-sect beginnings to its modem state of rapid growth and public acceptance.


In a novel analytical method, ultra-filterable calcium concentrations in blood were determined using liquid chromatography/tandem mass spectrometry (LC-MS/MS). Calcium present in blood serum of non-clinical adult males was analyzed following complexation with trans-1,2-diaminocyclohexane-N-N-N-N-tetraacetic acid monohydrate (DCTA). Results derived from this method demonstrated good agreement with accepted values for blood serum levels of ultra-filterable calcium, from which the concentration of physiologically-active ionized calcium may be estimated. This method provides a rapid, inexpensive means of analyzing large numbers of samples while requiring minimal sample volumes (0.1 mL), showing considerable potential for clinical and pharmacokinetic applications. This method, which can easily be used for quantitation of total calcium as well, is also applicable for assessment of calcium's isotopic distribution.


In March 1990, just a few months after the collapse of the East German state and the opening of the Berlin Wall, the conservative Christian Democratic Party (CDU) headed by Chancellor Helmut Kohl won a resounding electoral victory in East Germany. The government then declared its intention to unify the two German states by essentially annexing East Germany (GDR) and extending West German laws and institutions to a united German state (FRG).1 Abortion became a major subject of public debate when legislators and activists from West and East Germany demanded the maintenance of the liberal East German abortion law and the


The virus-free plantlets resulted from the meristem culture of two potato (Solanum tuberosum L.) cultivars i.e., Marphona and Desiree were grown and their shoot tips and roots were cut off. Stems were sectioned to three upper, middle and lower segments and transferred onto four planting beds: (a) peat mass: perlite (3:1), (b) turf: perlite (3:1), (c) Leaf mould: perlite (3:1) and (d) rice hull: turf (1:1). The mini-tubers were harvested and biometrically analyzed for their number, total weight, average weight, average numbers of eyes and the average diameter of the mini-tubers generated by a single plant. It was revealed that rice hull: turf (1:1) was superior to other beds. The effect of stem position node on the total weight of minitubers, except an interaction between node position and planting-bed was non-significant. Desiree was only superior in total weight of the generated mini-tubers compared to Marphona.


Harnessing innovative insights from cognitive pragmatics, this thesis examines the role of the Greek connective γάρ in the letter to the Romans. Traditional accounts which explain γάρ as "causal", using the English gloss "for", are inadequate. Γάρ occurs frequently in Romans, at pivotal points, but is treated inconsistently in exegesis. The thesis uses the framework of relevance theory and its notion of procedural meaning to suggest a consistent, cognitively grounded account of the communicative role of γάρ. The first half of the study presents the findings of the analysis undertaken. It demonstrates a unified explanation of all occurrences of γάρ in Romans, showing that its core function is procedural, guiding towards the inferential procedure of strengthening. Γάρ is not a whiteboard onto which interpreters can impose their prior perspective, but a crucial signpost guiding towards communicator intentions. The second half of the thesis demonstrates how this procedural account transforms the connective's contribution to the interpretation of Romans. Firstly, it enables us to decide between major exegetical options in contested passages such as Romans 4:1-2 and 10:45. Secondly, in the pivotal passages 1:15-18 and 15:7-13, it throws light on the centre and thrust of the epistle's argument, and on its purpose. We argue that interpretations which overlook γάρ as inferential signpost at such major argumentative crossroads are in danger of arriving at the wrong destination. Similarly undermined are readings which ride roughshod over the indications γάρ gives of close continuity with the preceding cotext. So too are interpretations which, by focusing on weighty but supporting theological statements, miss the main thrust of the argument. Meanwhile our analysis supports a context-specific reading of the letter's purpose as a response to tensions confronting believers in Rome. We finish by following the guidance γάρ gives to trace afresh the argumentative path of Romans 1-4.


The susceptibility of mice to intranasally inoculated vesicular stomatitis virus was significantly altered by daily exposure to 3-hr periods of high intensity sound (123 db). Animals inoculated before and after the first period of stress showed an increase in susceptibility. Adrenalectomized mice inoculated on the 2nd day of stress responded in a like manner. Susceptibility of intact mice inoculated on days subsequent to the first was biphasic. Animals inoculated before stress were more susceptible, whereas those inoculated after were more resistant to the virus than the controls. Daily stress subsequent to the day of inoculation further influenced susceptibility.
 The increase in susceptibility was independent of adrenal functions. The refractory phase appeared to be related to adrenal activity.


This article highlights the question of the necessity of system approach in organizing harmonization of Russian technical standards of technical documents in the field of labour safety and environment, and its adaptation to modern international standards of safety and quality. The urgency of the problem is shown on examples of estimating atmospheric air pollution of populated areas by industrial emission and the noise relative dose calculation at workplaces.


The research will describe China's foreign policy over Iran'snuclear program in international politics. The study of thisresearch includes how China to reach the national interest,submit its support for Iran's nuclear program. China is one ofsecurity council member of united nations that posses vetoright permanently, so that China's role is related tosignificant influence toward Iran's nuclear program andmiddle east and international stability. The research appliesrealism approach in explaining China's motivation toimplement its foreign policy in supporting Iran's nuclearprogram with nations-state level analysis. The researchapplies qualitative method. The research describes thatChina's attemps to maintain its energy security bysubmitting its support over Iran's nuclear program.


Chong, L.C. and Thurner, M.-O. "A Strategic-Options Perspective for the Management of Subsidiaries in Emerging Markets", Academy of Management Conference, New Orleans, August 2004


Over time the shipping lines grew to see the Atlantic as their own: a space they controlled in terms of the travellers' experience. Following the end of the Second World War, UK-based Cunard (one of the largest passenger lines) sought to re-establish business very much as in the 1930s. The emergent airline industry used the language and imagery of the shipping lines to build their customer base whilst making much of the benefits of shorter crossing times for both business travellers and those on holiday. In contrast, shipping lines such as Cunard struggled to come to terms with the demise of a market based on one mode of transport. Whilst making moves to enter the airline business, the company believed that ships would retain significant market share of the trans-Atlantic market. Eventually the company declared that "people who need transport will use the air … ships are for leisure".


Sabila Transport Company is a company engaged in the vehicle rental services and tour packages . This company is one of the leading companies in Yogyakarta , but the handling of the order and how to order the data is still simple to use way . Data processing is less tidy can cause errors in each order will be processed by the company .
Based on these problems , need to build a system capable of handling the booking process until the data processing orders cent to become more optimal . The system is capable of handling the booking process , data processing orders as well as rental vehicles travel packages Sabila Transport .
Booking Information Systems Vehicle Rental Services and Tour Packages built using Codeignniter framework and MySQL database. The system can order various types of transportation and tour packages online.


The Place to Spend a Happy Day may be purchased from Mrs. S.Soder, Hon. Secretary The Gravesend Historical Society. 58 Vicarage Lane, Chalk, Gravesend, DA12 4TE at 5.60 [pounds sterling] (inc. p.& p.). Cheques payable to Gravesend Historical Society. Theatre, performance and technology: the development of scenography in the twentieth century. Christopher Baugh. Palgrave, 2005. 272 pages. Hardback 47.50 [pounds sterling], paperback 15.99 [pounds sterling] ISBN (hb) 978 1403916969, (pb) 978 1403916976. In Theatre, performance and technology: the development of scenography in the twentieth century, Christopher Baugh convinces his reader that, instead of being a footnote to theatre history, technology should be considered integral to our understanding of the way theatre has developed. With works such as Philip Auslander's Liveness, performance and technology is a hip topic. Baugh's contribution aptly illustrates that the interdependence between technology and art is clearly not a new development. Baugh portrays the technological aspects of productions as more than background, but central collaborators to a performance. The book has an ambitious scope, including scientific discoveries along with contemporaneous developments in visual art. Baugh provides eloquent examples of the ways in which scientific discoveries and theatrical innovations interrelate: from obvious examples such as the invention of electricity, hydraulic systems and sound recording, to not so obvious influences such as Einstein's theory of relativity, the concept of sub-atomic particles and the x-ray. Additionally, Baugh convincingly refers to the influences of the Futurists, Cubists, Impressionists, and the Bauhaus on theatrical aesthetics. Throughout, Baugh exhibits extensive knowledge and investment in his subject matter, providing plentiful examples and historical contextualization. In his prologue, Baugh poignantly describes his childhood joy at categorizing his mother's button box, utilizing the memory as a metaphor for a Derridean archive. Working to resist a linear narrative, his book utilizes a worthy methodology, yet some of his classifications and chapter titles do come across as random. Baugh organizes the majority of his chapters thematically around innovations in set design, lighting and architecture. By doing so, each chapter may be useful on its own to specific disciplines, but I wanted the book's main points to be tied together more succinctly. In addition, the book's organization induces Baugh to reintroduce various theatre-makers and movements throughout the book, which proves awkward at times. After a beginning chapter providing a somewhat overwhelming look at various technological developments during the nineteenth century, Baugh hits his stride when looking at the modernists' multiple rejections of realism. Baugh re-examines the 'big bangs" (36) of theatre history, providing a technological edge. Baugh utilizes his metaphor of 'the scene as machine-as a physical construct that theatrically locates and enables the public act of performance'(46) to further explore such important contributions as Craig's screens and Meyerhold's biomechanics. …


Houston Geological Society Bulletin 29 The Eagle Ford Shale (and the laterally equivalent Tuscaloosa Shale) of the Gulf Coast Basin has long been considered to be a source rock for Mexico, Texas, and northern Louisiana production, but is now drawing interest as a resource play. With industry focus on non-conventional reservoirs and advancements in multilateral horizontal completion technology, fractured bituminous shales have become viable exploration targets. Wellknown examples of shale reservoirs include Bakken Shale (Mississippian of Williston Basin), Barnett Shale (Mississippian of Forth Worth Basin), Woodford Shale (Late Devonian/Early Mississippian of Arkoma Basin), and Marcellus Shale (Middle Devonian of Appalachian Basin). The Cretaceous experienced three major oceanic anoxic events, including one at the CenomanianTuronian boundary, represented by the Eagle Ford, and it is not surprising that exploration interest is now being attracted.


To explore in extreme environments, such as a lunar surface or volcanic area in the earth, our research group has been developing small-sized tracked robots, called "TrackWalker" and "TrackWalker II", in a joint research project with JAXA. Each robot mounts two side sub-tracks, and each sub-track has a swing mechanism to enable simple legged locomotion for traversal on a weak a soil. From 2010 to 2011, we have conducted some field tests using the tracked robots and improved its weakness, and executed performance assessments. In 13 th , March, 2012, JAXA organized a debrief session combined with field test in Nakatajima dune, in Hamamatsu, and we performed hill-climbing demonstration. In this paper, we introduce a brief of mechanism of TrackWalker-II, and report some field tests, including Nakatajima experiment.


1. LINEAR REGRESSION (25) 1.1. Let X be an independent variable and Y be a dependent variable. Given a set of pairs of values (X i , Y i) it is desired to calculate a best fit for the points Y i using the method linear regression. Show the mathematical formulation of the problem and derive value for the regression coefficients in terms of the (X i , Y i) values. For sake of simplicity you can assume X and Y to be one dimensional variable.


Experimental research and theoretical analysis on shrinkage crack,which is common in block wall,are conducted in this paper.Tests are performed with three walls to contrast the effectiveness of different construction methods.The stress states of walls are studied by using finite element programme.Practical and effective methods are presented.


A cell-free system that catalyzes 4X174 repli- cative form I (supercoiled circular duplex, RFI)dependent 4X174 DNA synthesis has been isolated from Escherichia coli infected with 4X174 phage. The products formed with such preparations are viral strands as judged by hybridization to poly(U,G) followed by equilibrium centrifugation in CsCl. This 4X174 DNA-synthesizing involves formation of DNAprotein complexes that sediment in neutral sucrose with S values of 50, 60-70, and higher. The S0S complex contained a rolling-circle replicative intermediate DNA with an extended tail of single-stranded viral DNA. The DNA contained in the 60-70S region was a mixture of circular and linear single-stranded DNA, RFI, and RFII with an extended single-stranded tail. Such complexes have been isolated during in vivo progeny 4X174 DNA synthesis [Fujisawa, & (1976) Virol. 19, 409]. In vitro, maximal 4X174 DNA synthesis was shown to require the genetically defined proteins E. coli dna B, dna C, dna G, dna Z, rep, OX174 gene A product, and other kX174 coded proteins. The synthesis of OX174 DNA is ATP-dependent and is inhibited by nalidixic acid and novobiocin but is resistant to rifampicin. I to an RFIV form (relaxed RF, f) which can be converted to RFI by DNA gyrase (11, 12). The replication of RF is blocked by 4X174-coded proteins essential for phage maturation. This is detected by a cessation of complementary strand formation. In this way, upon conversion to RFII-4sX174 A protein complex, RFI can only support ss DNA synthesis. This pathway yields a RFII forms containing ss tails complexed to phage proteins in which only the viral strand is labeled (g). Viral strand DNA synthesis occurs by formation of short discontinuous fragments that are rapidly chased into large fragments (unpublished data) as in the case of RF replication. The 505 complex after action of the 4X174 A protein regenerates the RFII-A complex (d) and leads to formation of 60-80S complexes (h). These complexes vary in size due to changes in viral proteins associated with the DNA and formation of various DNA structures. Eventually, these intermediates are converted to 132 S (i) and then to phage [114 S, (j)].


The actual problem of obtaining qualitative assessment of socio-economic indicators is the account of hiddenand informal activities on the basis of differential methods. They have a function of adjustment and directed toadjust the figures in the official statements. This allows you to have a fairly complete assessment of theeconomic transactions that fall outside the normal statistical error. However, obtaining them is complicated bythe inadequacy of the output indicators. This raises the need to use different methods of estimating the hiddenphenomena and how they characterize.


The frequency and power of the microwave radiation detected from long in-line Josephson tunnel junctions when dc biased on low order singularities or self-induced steps have been measured as a function of bias current and externally applied magnetic field. The preliminary experimental results reported here show that the magnetic tuning of the emitted radiation may be considerably greater than that obtained in similar junctions of overlap geometry.


Mealiness degrades the quality of apples and plays an important role in fruit market. Therefore, the use of reliable and rapid sensing techniques for nondestructive measurement and sorting of fruits is necessary. In this study, the potential of acoustic signals of rolling apples on an inclined plate as a new technique for nondestructive detection of Red Delicious apple mealiness was investigated. According to destructive confined compression tests, the mealiness of apples was evaluated by the hardness and juiciness measurements. In addition, support vector machine (SVM) models were developed to classify apples. The radial basis function (RBF) as the kernel was used in SVM models. According to exhaustive search method, the model with nine features combination was found to be the best model. Results indicated overall accuracy of 85.5 % to classify apples in mealy and healthy groups. The results indicated that this method is potentially useful for apple mealiness detection.


Idiopathic nephrotic syndrome (NS) is characterized by proteinuria, edema, and hypoalbuminemia. The aim of the study was to identify differentially expressed proteins in urine and plasma during NS compared with remission.


Phosphatase and tensin homolog (Pten) antagonizes PI3K‐Akt signaling; therefore, Pten impairment causes tumorigenesis. However, the correlation between Pten deficiency and colon cancer has remained elusive due to numerous opposite observations. To study this correlation, we examined whether Pten deficiency in intestinal epithelial cells (IECs) induces tumorigenesis.


After six years experiment of different artificial afforestation models of pure and mixed forest of Liquidambar formosana Hance and comparative analysis of their biomass and productivity,it is concluded that the mixed forest of Chinese fir and Liquidambar formosana Hance has a higher biomass and productivity than pure Liquidambar formosana Hance forest has.


Twenty cases of typhoid and brucellosis patients were studied on clinical, serological and biochemical aspects. The mean clinical findings were, most of the cases had sustained fever 66%, gastroenterial symptoms developed as the disease progressed and intestinal hemorrhage 19% as a complications. Inserological findings, the number of patients who had +ve positive widal test were thirteen and those who had positive Rose Bengal test were five and those who had positive Widal and Rose Bengal test were two patients. The study was also conducted on ten apparently healthy individual as a control group.The objective :(1) To study the possible correlation between brucella infection and salmonella typhi infection by biochemical test of some serum salts, and(2) Because of the limited value of Widal's test in the diagnosis of typhoid fever, serum salts of these patients studied to see if can be used as a recommended test to differentiate between these two diseases.
The biochemical findings were reveled a significant increase in the level of serum magnesium (P0.004) and a significant decrease in the level of serum potassium (P0.003) in typhoid fever patients. While patients with brucellosis show moderate increase in the mean value of serum magnesium and sodium (P0.1 and P0.08 respectively) and moderate decrease in the mean value of serum potassium (P0.08).While patients with typhoid and brucellosis (combination) show significant increase in the mean value of serum magnesium and sodium (P0.001 and P0.001 respectively) while there is increased in the level of serum total calcium (P0.1) in patient with typhoid fever only. While serum ionized calcium show significant increase in the mean value in patients with typhoid fever and brucellosis (P0.06).The changes in these biochemical parameters were well discussed .


Lateral thoracic radiographs of 75 dogs and 16 cats with tick toxicity, sequentially presented to a veterinary hospital, were examined for evidence of megaoesophagus and lung changes, specifically for evidence of aspiration pneumonia, pulmonary oedema, a bronchial pattern and dilation of the right cranial lobar pulmonary vein. In dogs, the two most frequent changes were pulmonary vein dilation (38%) and a bronchial pattem (25%), followed by megaoesophagus (17%), aspiration pneumonia (7%) and pulmonary oedema (1%). Sixty-four percent of dogs had at least one of these findings, and 18% had at least two findings. The mean pulmonary artery to pulmonary vein ratio of all dogs measured was 0.97 (normal = 1). In those with dilation of the pulmonary vein the ratio was 0.7. These findings indicated that many (38%) dogs had early signs of pulmonary congestion. The thoracic radiographs from this group of cats were unremarkable, except for one cat with pulmonary vein dilation.


We have previously described the discovery of a highly potent, selective and orally bioavailable Src kinase inhibitor NXP900 with a unique binding mode relative to other Src inhibitors under clinical development or approved (Temps et al 2021). This unique binding mode locks SRC in its native inactive conformation, thereby inhibiting both enzymatic and scaffolding functions. Also, in contrast to other Src inhibitors in the clinic, NXP900 exhibits a unique target selectivity profile with 1000 fold selectivity for Src over Abl kinase. The aim of this current study was to perform broad cancer cell line panel screening to inform disease positioning and identify predictive biomarkers of sensitivity for this novel class of Src kinase inhibitor. We describe the results of extensive cancer cell line panel profiling across a suite of 2-dimensional(D) and 3-D in vitro cell viability and high content phenotypic profiling assays that has revealed clear patterns of cell line sensitivity and insensitivity. Among the most sensitive cell line subtypes are, squamous cell carcinoma, Arid1A mutant ovarian clear cell carcinoma and subtypes of breast luminal A and triple negative breast cancer cell lines. HER2+ breast cancer lines appear insensitive to NXP900 indicating HER2 as a potential driver of resistance to NXP900. Further in-depth bioinformatic analysis of genetic and transcriptomic profiles of sensitive cell lines has identified putative biomarkers to support patient selection and personalized healthcare strategies. These studies demonstrate the identification of cancer cell lines which exhibit high sensitivity to NXP900 and which can be grouped into discrete molecular subtypes based on gene mutation status, transcriptomics and histotype. Our result provide an indication of patient subgroups which may exhibit optimal therapeutic response to NXP900 and provide data to guide further preclinical, biomarker and clinical development. Temps C et al., Cancer Res. 2021 Nov 1;81(21):5438-5450. doi: 10.1158/0008-5472.CAN-21-0613.
 Citation Format: Neil Carragher, Rebecca Hughes, Valerie Brunton, Asier Unciti-broceta, Iñigo Lanzagorta-Calvillo, Carolin Temps, Enrique Poradosu. Uncovering the molecular mechanisms which predict sensitivity to a novel src kinase inhibitor NXP900 to inform personalized healthcare strategies [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 3326.


In this paper, a multi-product continuous review inventory control problem within batch arrival queuing approach (MQr/M/1) is developed to find the optimal quantities of maximum inventory. The objective function is to minimise summation of ordering, holding and shortage costs under warehouse space, service level and expected lost-sales shortage cost constraints from retailer and warehouse viewpoints. Since the proposed model is Non-deterministic Polynomial-time hard, an efficient imperialist competitive algorithm (ICA) is proposed to solve the model. To justify proposed ICA, both ganetic algorithm and simulated annealing algorithm are utilised. In order to determine the best value of algorithm parameters that result in a better solution, a fine-tuning procedure is executed. Finally, the performance of the proposed ICA is analysed using some numerical illustrations.


Knowledge source plays an important role in organizational knowledge transfer. In franchise network,knowledge source which engenders and diffuses new knowledge can influence organizational knowledge transfer effectively. Based on analyzing knowledge source influencing organizational knowledge transfer,this article points out that capability,credibility,motivation,and competition of the source in franchise network significantly affects organizational knowledge transfer. By case study,it also brings forward that it is in favor of knowledge transfer in franchise network by enhancing the capability,credibility of the source and sticking up for the benefit of members in franchise network.


A method for adapting a food-cooking process in which that are available located on a food support (20) foods (24) at the beginning and at the end of a cooking process by a camera (22) detects, by comparing the texture of the food (24) before and after the cooking process to draw conclusions on the cooking process, and can be modified depending on the conclusions parameters of a cooking process for future similar foods.


Aiming at applying virtual time mechanism to data race detection,a model is proposed to uniformly describe different implementation forms of virtual time. We firstly establish an abstract model for a distributed execution. Based on this model,we give a unified description on virtual time 's three basic implementation forms: scalar time system,vector time system and matrix time system. Furthermore,we take vector time system and matrix time system for examples to illustrate four optimization techniques for virtual time. At last,we discuss the problems to be solved when applying virtual time to data races detection in shared- memory concurrent systems and four application examples. The model proposed in this paper unifies different implementation forms of virtual time and reduces the difficulty of applying virtual time to data race detection.


A chemically amplified resist containing a basic monomer, 3- (t-butoxycarbonyl)-1-vinylcaprolactam (BCVC), in the matrix polymer was synthesized with various monomer feed ratios. Diffusion and evaporation of photogenerated acid in the copolymer films were investigate for various fractions of the basic units in copolymers. It is found that only acid surviving deactivation by the BCVC units diffuses into unexposed areas and evaporates for the copolymer film to bleach the indicator film. Evaporation of a low molecular weight basic additive is also examined. Whereas the low molecular weight basic additive evaporated during baking, the basic monomer units in the copolymer did not evaporate at all due to covalent bonding to polymer backbone chain. Thus, the copolymer with the basic monomer can control the acid diffusion and evaporation effectively. The new resists system enables us to form fine patterns even after post- exposure delay of 2 h without any additional treatment.


This report describes work done by the Applied Meteorology Unit (AMU) to add composite soundings to the Advanced Weather Interactive Processing System (AWIPS). This allows National Weather Service (NWS) forecasters to compare the current atmospheric state with climatology. In a previous phase, the AMU created composite soundings for four rawinsonde observation stations in Florida, for each of eight flow regimes. The composite soundings were delivered to the NWS Melbourne (MLB) office for display using the NSHARP software program. NWS MLB requested that the AMU make the composite soundings available for display in AWIPS. The AMU first created a procedure to customize AWIPS so composite soundings could be displayed. A unique four-character identifier was created for each of the 32 composite soundings. The AMU wrote a Tool Command Language/Tool Kit (TcVTk) software program to convert the composite soundings from NSHARP to Network Common Data Form (NetCDF) format. The NetCDF files were then displayable by AWIPS.


The present invention, one or more of the catalyst compounds is contacted with the pre-treating agent containing aluminum alkyl and / or alumoxane in solution, one or more comprising causing thereafter contacting the combination with a supported active agent about supporting method of the catalyst compound.


As part of the Miami Intermodal Center (MIC) development program, the MIA Mover Automated People Mover (APM) System is Miami-Dade County's contribution to the MIC Program. The MIA Mover is under development by the Miami-Dade Aviation Department (MDAD). MDAD is currently implementing the MIA Mover development under a DBOM (design-build-operate-maintain) delivery method, with the Phase I design-build components scheduled for completion in September 2011. The MIA Mover will operate on a 1.27-mile elevated guideway between the airport terminal (MIA Station) and the intermodal center (MIC Station). Under design-build delivery, fixed facility design and construction activities are interconnected. This presents unique challenges for the fixed facility design-build contractor and the owner. A relatively new procurement technique for APM systems in the United States, the design work is phased so construction work can be initiated prior to completion of the design; a foundation to roof/super-structure (bottoms-up) approach is deployed to accelerate the work. Engineers and contractors coordinate closely to address potential field conditions during the early design development. The design-build contractor and the owner meet frequently to address opportunities and constraints to expedite reviews and approvals. As with every transportation project, cost is a dominant factor. With a budget fixed in 1996, the design-build contractor developed and negotiated multiple technical and administrative alternatives to design and construct the 2008-2011 MIA Mover APM System within the owner's budget constraints.


Proteins can act as exquisite nanomachines to produce or sense the motion associated with cell division, intercellular trafficking, muscle contraction, and countless other activities.


Using the feed involved Methyltestosterone(MT) to feed multiparity female Zebrafish(Danio rerio) for 30 d to detect the effect of foreign hormone on the gonad development.After 30 d feeding by the diet which contained 0,30,60,120 and 240 and 400 mg·kg-1 MT,paraffin sections were made to observe the development of ovary.Results showed that,with MT dosage increased,the gonadal growth of the females were obviously inhibited,and the ovarian structure changed obviously.At the dosage of 30 mg·kg-1,the maturity ratio dropped comparatively to the control.When the treated dosage rised to 400 mg·kg-1,the maturity ratio was only obove 1/6 to the control group.Meanwhile,the foreign MT inhibited the ovarian development.For lower dosage treatments,they were stopped at the III phase.And the higher dosage treatments,the ovaries w retrogression.In the group of 400 mg·kg-1,there was even no ovocyte could be found.The ovocyte retrogression was as follows: inhibition-structure change in nuclear-cellular organ disintegration-apoptosis body formed,memberance destroy-apoptosisi body dissipation-disintegration.Therefore,at some dosages,the foreign MT would inhibite the gonard development and the high content MT feed could castrate the fish.


ABSTRACT Since consideration of individual customer' demands is of increasing importance, enterprises are in need of more flexible production for highly customized products even in serial production. Hence, innovative concepts for improved information logistics are necessary for competitive manufacturing. This paper presents an approach for integrated agent-based process planning and production control and focuses on further applications like temporal logistics networks, which will gain benefit from agent technology. Due to broad application of techniques like multiagent systems and bottom-up integration of innovative management concepts, a new kind of inter-enterprise cooperation will arise, which will lead to "emerging virtual enterprises". Key words: emerging virtual enterprises, integrated process planning and production control, intelligent agents. 1. INTRODUCTION Since the last decades, global economy and liberalization are leading to management trends such as just-in-time, or reduction of vertical range of manufacture to realize shortened time-to-market and a more flexible consideration of customer' demand. However, modern industrial products are often characterized by a high complexity of design, functionality and necessary manufacturing and assembly processes. Computer systems for the support of process planning, production control, and scheduling tasks have to handle critical paths, bottlenecks and risk of failures within real-time. In the context of design and manufacturing of complex and sophisticated products the planning and scheduling tasks involve a high degree of knowledge ab out the product. In computer science especially artificial intelligence there is a trend to more distributed and federated systems. Agent technology is a key approach to sophisticated, distributed and self-coordinating systems, which gain great benefit and implement global optimization algorithms through mutual cooperation. This non-deterministic behavior is addressed to as


: Vicia sabinarum J. Gil (Faba -ceae), sp. nova of subgenus Cracca Pe-term. , sect. Cracca Dumort. is described and illustrated from the isle of El Hierro, Canary Islands, north-west of Africa. It is related to and compared with Vicia aphylla


This special issue of Annals of Geophysics is dedicated to present and discuss a research infrastructure whose goal is integrating and providing access to solid Earth science data, research products and services as well as promoting physical access to research facilities.  This research infrastructure is the European Plate Observing System (EPOS, www.epos-eu.org). The idea of the special issue was matured considering the centrality of research infrastructures in the research process, promoting open science and enabling new forms of research and collaborations by providing solutions to share and distribute data and scientific products. Research infrastructures play a key role in establishing and consolidating interactions between research organizations and academia to govern and manage virtual access to scientific data and physical access to research facilities. Moreover, by providing access to scientific data, products, and information they represent a collaborative framework to foster innovation directly contributing to scientific progress and education in specific scientific domains.


Anemia is a condition often encountered in the elderly, with prevalence
estimation ranging from 9-18% in men and 8-13% in women and increased to 20% at
age above 85 years. The cause of anemia in the elderly associated with bleeding or
nutritional deficiency, chronic disease and an unknown cause. Anemia is an
independent predictor of adverse outcomes for the elderly. Symptoms are frequent in
patients complaining of anemia is directly related to fatigue, namely subjective
sensation of weakness, loss of energy and fatigue, both physical, emotional,
cognitive, and will affect the quality of life of elderly patients. Quality of life is the
sum of ability, disability, complaints and feelings of that occurs as a result of illness,
treatment or medical intervention. The purpose of this study was to determine the
correlation between hemoglobin levels with quality of life in the elderly who live in
Panti Werdha.
Research using cross-sectional research design in the elderly in Panti Werdha
Province of Yogyakarta. Research time was conducted in November 2010. Elderly
people who meet inclusion and exclusion criteria, underwent physical examination,
routine blood tests and assessment of quality of life using short-form-36 direct
interview. Statistical test was done with Pearson correlation for normal data and
Spearman's correlation when the data is not normal. Differences considered
significant if p <0.05 with 95% confidence interval.
The results present the characteristics of study subjects by age, sex, educational
level, BMI, and comorbid disease. Categorical data are presented in percentages and
numeric data in mean and standard deviation. This study shows the correlation
between hemoglobin levels with quality of life of elderly in Panti Werdha, DIY.


Parasagittal meningiomas comprise 20/30% of all intracranial meningiomas. Because of their location and by definition involvement of the sagittal sinus and and/or surrounding bridging veins, radical surgery without potential morbidity is challenging. A subtotal resection is often recommended with the argument that meningiomas are benign and slowly growing tumors. This simplistic approach is very controversial when a close look at long-term follow-ups is being given. Lesser degree of resection based on Simpson classification is associated with a higher recurrence rate. A 25 year long-term follow up study of this kind of tumors has been performed by Pettersson-Segerlind et al at the Karolinska Institute in Stockholm [1]. This study shows a 47% total recurrence in a cohort of 51 patients. Ten and 25 year recurrence rates for apparently radically operated parasagittal meningioma (Simpson grade 1 or 2) were 13% and 38% respectively, whereas they were 33% and 42% for Simpson grade 3 and 62% and 69% for Simpson grade 4. The relative risk for recurrence in Simpson grade 4 was 1.78 compared to Simpson grade 1-3. Sweden is a homogenous country with comprehensive cancer, mortality, and population registries that support collection of long-term data and enable this type of study of long-term survey study and natural history. Interestingly enough the 10 and 25 year mortality rates reported were 33% and 63% respectively. Of the total mortality 50% was caused by the tumor after 10 years and 48% after 25 years.


Abstract              This study seeks to examine the behaviors and motivational attributes of golf tourists, the potentials for golf tourism, impacts on communities of golf tourism, and the development of golf tourism management in southern provinces on the Andaman coast. The samples included 110 Thai and foreign golf tourists visiting golf courses in southern provinces on the Andaman coast, namely Ranong, Phang-nga, Phuket, Krabi, and Trang,        5 golf course operators, and 10 others who were academicians and relevant parties from the government and private organizations. The instruments were a questionnaire, an in-depth interview, and a focus group discussion. Statistical tools included mean, standard deviation, and content analysis. The study revealed that sustainable and golf tourism required five attributes: attractions, events/tournaments, travel packages, participation, and knowledge.       1) Attractions refer to places in the southern provinces on the Andaman coast with characteristic geographical features and facilities. 2) Events/Tournaments refer to golf activities or tournaments during a certain time in the southern provinces on the Andaman coast. 3) Travel packages include golf tourism packages in the southern provinces on the Andaman coast. 4) Participation refers to the participation of communities in the southern provinces on the Andaman coast. 5) Knowledge refers to the ability to use the body of knowledge to improve sustainable golf tourism in the southern provinces on the Andaman coast to create new methods to impress tourists.


Stimulated by the requirement for wearable electronics, crack‐based strain sensors made from polymer‐supported metal films have been reported as a prospective structure for detecting subtle deformation with ultrahigh sensitivity and excellent flexibility. However, the regulation of crack preparation remains a challenge and the use of noble metals retards the large‐scale promotion toward practical application. Here, a cost‐effective strain sensor with ultrahigh strain sensitivity under small strains (ε) is designed based on the submicron to nanoscale voided clusters in Cu‐Al alloy films. The formation of channel cracks in the film is manipulated by regulating the intrinsic microstructure of the film, and the corresponding mechanism is discussed in detail. The strain sensor developed from the cracked Cu‐Al film exhibits ultrahigh gauge factors as high as 584 (0% < ε < 0.5%), 10219 (0.5% < ε < 0.9%), 43152 (0.9% < ε < 1.75%) which is among the highest in reported values. Furthermore, the practical application of the developed sensor in wearable electronics and detection of small deformation is demonstrated. This work provides a novel approach to optimize the sensing performance of flexible strain sensors.


We have investigated whether or not the temporal correlation in time series of angiograms can be utilized to improve the efficiency of reversible data compression. Reversible methods for motion-compensated and non motion-compensated temporal decorrelation in combination with spatial decorrelation have been considered. The conclusion is that the interframe decorrelation techniques considered so far are not substantially better than intraframe techniques.


Introduction Spastic paresis of calves was first described as such by Gotze (1932) in Germany. The condition has also been referred to as "contraction of the Achilles tendon", "straight hock" and "Elso-heel", and had been described earlier by Hamoir (1922) in Belgium, and Wester ( 1922) in the Netherlands. Hickman (1964) considered the use of the term "spastic" misleading in describing this type of lameness as it implied neurological involvement, with increased tone, exaggerated reflexes and a degree of paralysis. As these signs are not a feature of the condition he considered "congenital shortening of the gastrocnemius and superficial flexor" a more accurate definition. Although Gotze (1932) described the occurrence of spastic paresis in calves from 3 t to 6 months of age, Rosenberger (1939) indicated that signs could appear at 2 years or later. Gotze (1932) described a form of spastic lameness in which one or both hind limbs could become affected. In the majority of cases only one leg is affected, but bilateral occurrence is by no means rare (Wintzer 1968). The first signs to become apparent in calves are a straightness of the hindlimbs and a tendency for the calcaneus to be drawn toward the tibia. Sometimes the abnormality of gait is found in the first few days of life, but usually the spastic condition is not seen till 6 weeks to 8 months of age when it becomes more obvious (Hickman 1964; Dirksen 1970). Both hind legs may become affected, but as the condition progresses over a period of a few weeks or months one hind leg becomes more severely involved. The pastern of the affected limb becomes more upright than the other with the foot still placed on the ground. Later the leg is held so that the foot just touches the ground with the toe. Eventually this leg becomes raised entirely free of the ground and a "pendulum" action results when the animal is moved. The gastrocnemius muscles appear under-developed and there is a characteristic raising of the tail. Spasticity affecting the gastrocnemius and superficial digital flexor muscles is especially


SYSTEM ADJUSTABLE BACK CHAIR OFFICE CARRYING A SETTING SEPARATE PART TORACICA AND PART Lumbar such support, the type in which a first support member ACTUA resiliently SUCH PARTY TORACICA is mounted pivotably ON BUCKET OF FIXED CONTROL OF SUCH SYSTEM SET, while a second support ACTUA resiliently SUCH PARTY LUMBAR, operating said first and second support independently of one another IN ROTATION BACKWARDS WITH RESPECT TO THE cHAIR, wherein the means MECHANICAL SECURING THE RESISTANCE STRETCH OF EACH two support elements each consisting of a body susceptible to deformation ELASTICA under the action of a torque, the two organs associated ONE TO ANOTHER SO THAT THE SECOND INTERVENE SEQUENTIALLY the first.


OBJECTIVE
Vaso-occlusive crisis is the most common clinical feature requiring opioid analgesics in patients with sickle cell disease. We conducted a network meta-analysis to compare the drugs that can be used as add-on with opioids for vaso-occlusive crisis.

DESIGN
Network meta-analysis of randomized clinical trials.

PATIENTS
Sickle cell disease patients with vaso-occlusive crisis receiving adjuvants to opioids for pain management.

MAIN OUTCOME MEASURES
A number of patients with complete pain relief and pain scores assessed either by visual ana-log or by a numerical rating scale were the primary outcomes. Adverse events and dose of opioids (in morphine equiva-lents) for pain alleviation between the treatment arms were the secondary outcome measures.

RESULTS
Eleven studies evaluating the addition of ketorolac, magnesium sulfate, ketoprofen, ibuprofen, methadone, inhalational nitric oxide, methylprednisolone, and arginine with morphine were obtained. The pooled analysis showed a favorable effect in the pain reduction for the additions of arginine {-2 [-3.39, -0.61]} and ibuprofen {-1.7 [-3.26, -0.14]} with morphine. Arginine has high probability of being the "best" in the pool followed by ibuprofen. No significant differ-ences were observed in the risk of adverse events {ketoprofen-0.84 [0.42, 1.65]; magnesium sulfate-1.81 [0.64, 5.81]; and arginine-2.08 [0.18, 24.31]}. A significant lower dose of opioid was required when given adjunctive to argin-ine, inhalational nitric oxide, and methylprednisolone.

CONCLUSION
We observed that arginine and ibuprofen could produce additional analgesic effects when combined with morphine in vaso-occlusive crisis.


The article considers the mechanism of action, indications for use and analysis of efficiency of using the macrolides, in particular spiramycin, in case of respiratory tract infections in the outpatient setting.


Primary bone lymphoma (PBL) is an uncommon clinical entity and a rare non-Hodgkin's lymphoma presentation. PBL
accounts for less than 5% of malignant bone tumours. Gastric lymphoma (PGL) is also rare cancer, but it is the most
common site for extranodal non-Hodgkin lymphoma. We report a rare case of concurrent occurrence of bone lymphoma and gastric lymphoma.
The patient presented with a slow-growing swelling around the knee joint for two years. Positron emission tomography incidentally picked up an
FDG avid lesion in the fundus of the stomach. Tissue specimens of both the lesions were obtained and conformed to have diffuse large B cell
lymphoma on histology and immunochemistry. He is on follow up with the oncology department and being treated with an R-CHOP regimen
(rituximab, cyclophosphamide, hydroxydaunorubicin, oncovin (vincristine), and prednisone.