In the recent work, Sanctifying Interpretation, Chris E.W. Green contends that Pentecostals need to reconsider how they handle the Scriptures. While Protestants typically talk about Scripture 'from above' by concentrating on its nature, Green suggests that Pentecostals ought to talk about Scripture 'from below' by concentrating on its usefulness. For Green, this requires Pentecostals to shift the center of gravity from the epistemological to the soteriological. This conviction is felt in the book's arrangement with two sections on vocation (Chapters 1–3) and holiness (Chapters 4–5) preceding the last section on the reading of Scripture (Chapters 6–8). Most significantly, Green claims how God saves us must be undividable from what God saves us for (Chapter 3). The Spirit never saves us from interpretation, but gifts us by pushing us further into the difficulty of interpretation. In Green's words, 'God is not going to save us from interpretation but by it and for it.' (42) God's purposes, then, are found within the pains of interpretation (Chapter 7). The Spirit uses Scripture to trouble us in order that our imaginations and affections are transformed, working in us needed virtues. Sanctifying Interpretation, then, offers an original vision for handling the scriptures – one that ecumenically formed, but distinctly Pentecostal in its ethos. While Green's final section on reading and interpreting scripture serves as the work's highpoint, his treatises on vocation and holiness are also thoughtful and creative. As a whole, this work echoes Clark Pinnock's assertion that the church is called to be 'God's agents in the world' while also affirming that 'Scripture is primarily God's instrument of sanctification... ' However, this work is unique in that instead of offering a particular method, he offers practices 'in hopes of provoking the imaginative and affective sensitivities needed to read Scripture sanctifyingly'. (142) Thus, it is Green's assumed, guiding philosophical commitments that set this work apart from other works on Pentecostal hermeneutics. Sanctifying Interpretation, then, effectively helps loosen modernity's grip upon Pentecostal hermeneutics. While this is one of the major strengths of the work, in some cases it might serve as a potential difficulty, at least pedagogically. While arguably this monograph is working from a 'Pentecostal epistemology', some might find Pentecostal readers untrained in philosophy disoriented. One might consider that including a brief paragraph in the Introduction outlining several presuppositions that undergird the construction of the argument could have aided interested yet amateur readers, such as Pentecostal undergraduate students. Another potential drawback of the text is the deficiency of 'signposting' within the chapters on vocation and holiness showing how the Part I (vocation) and Part II (holiness) correlate to Part III (scripture). While Green does do this in a few various places (most notably in his introductions), the overall scarcity suggests that 'signposting' could have been more prominent throughout the whole. Nonetheless, Sanctifying Interpretation is worthy of attention. I recommend this monograph for both scholars and students of Pentecostal/Charismatic studies, for it offers an imaginative revisioning of Pentecostal scriptural interpretation that is worth serious consideration.


The Earth's inner core is solidifying from the liquid outer core, where convection currents power the geodynamo. Constraining properties of the inner core is fundamentally important, yet seismic models do not reconcile body wave and normal mode attenuation properties. Here we analyse high signal-to-noise ratio core-refracted (PKIKP) and core-reflected (PKiKP) waves generated by earthquakes recorded globally between 1987 and 2021. These phases are excellent indicators of uppermost inner core (UIC) properties due to their low angular separation at the core-mantle boundary and similar ray paths. We analyse their amplitude ratios (AR) and time delays (DT) relative to synthetic waveforms and estimate the required attenuation perturbations in a linearised attenuation tomography. The UIC is cylindrically isotropic and heterogeneous in both seismic velocity and attenuation. Contrary to the paradigm that the inner core is seismically hemispherical, we find more complex patterns of attenuation that correlate with seismic velocities, according to both Akaike criterion and Student's t-test. The UIC beneath NE Asia is weakly attenuating and seismically slower, in contrast to the expected properties associated with the quasi-Eastern hemisphere. Beneath South America, where the core is thought to grow fastest, AR values are more diverse, possibly reflecting interdendritic melt inclusions, and DTs show an E-W gradient. The UIC is seismically slow and weakly attenuating beneath the Atlantic, but strong anomalies emerge near West Africa. Attenuation slightly changes with depth conceivably implying an increase in melt degree or a change in inner core growth rate with time. These 3D heterogeneities are inconsistent with simple models of core translation or lopsided growth, indicating that more intricate processes are needed to explain inner core structure and evolution.


A new scheduling policy denoted least double-rate with first-come-first-served (LDR_FCFS) is proposed to improve the performance of adaptive multicast video-on-demand (VoD) systems. Simulation results show that the LDR_FCFS is very suitable for multicast VoD systems in terms of reneging probability and fairness.


This paper addresses the issue of whether covariation of long-term interest rates across G10 countries has increased in recent years and whether, as a consequence, interest rates have become less subject to the influence of national monetary authorities and domestic fundamentals. A conceptual framework based on the standard parity relations among country interest rates is described, and it is argued that historical trends in interest rates and their relations across countries can be understood reasonably well under this framework as the result of changing fundamentals and shifts in (internationally-priced) risk premia. The main empirical findings are that bilateral covariation of long-term interest rates has gone up in the 1990s among some European countries but there is no evidence of any substantial increase for countries with floating exchange rates. Variance decompositions and country-specific interest rate equations show little evidence of increasing interdependence of domestic ... Cet article etudie dans quelle mesure la covariation des taux d'interet a long terme dans les pays du G10 a augmente ces dernieres annees et si, en consequence, les taux d'interet sont devenus moins permeables a l'influence des autorites monetaires nationales et aux evolutions fondamentales internes. Apres la description du cadre conceptuel base sur les relations habituelles de parite des taux d'interet entre pays, il est demontre que, dans ce cadre, les evolutions historiques des taux d'interet et de leurs relations entre pays s'interpretent assez bien comme le resultat d'un changement des evolutions economiques fondamentales et des primes de risque (sur les marches internationaux). Les principales conclusions empiriques sont que la covariation bilaterale des taux d'interet a long terme, s'est accrue dans les annees 90 parmi quelques pays europeens mais qu'il n'y a aucun signe d'accroissement pour les pays a taux de change flottants. Les decompositions de la variance et des ...


Psoriasis is a chronic, inflammatory, immune-mediated disease, characterized by erythematous scaly plaques occurring in about 2-3% of the population. TNF- α plays a role not only in the inflammatory cascade but also in body weight homeostasis which could be disrupted by TNF-α inhibitors, such as adalimumab, infliximab, and etanercept, used for treatment of moderate-severe psoriasis. The goal of this study is to determine the association between the use of TNF-α inhibitors and weight gain in patients with plaque psoriasis based on available clinical trials. This article is protected by copyright. All rights reserved.


The efficient collection of data from remote devices representing distributed intelligence is becoming a fundamental requirement for competitiveness. The growth of embedded intelligence in devices, combined with the proliferation of the Internet, has expanded the market for short data messaging/monitoring from that of person-to-person, to the inclusion of person-to-machine, and machine-to-machine. The markets for short data messaging/monitoring services include Tracking and Fleet Management, Monitoring and Remote Control, Two-way Messaging, Emergency Services, and Transaction Processing. 'Little LEO' satellite systems are uniquely suited to address short data applications that have a requirement for wide area coverage and a sensitivity to cost. While satellite networks in general are optimum for serving applications with broad coverage requirements, Big LEO and K-band satellite systems have frequency and terminal characteristics that render them ill-suited to address many of the requirements of the short data messaging/monitoring markets.

Market research suggests that while the value proposition for an economical, low data rate communications capability is generally applicable throughout the world, those economies with the highest productivity and highest concentration of machines are the markets best suited to adopt a thin-route low cost means for inter-linking devices. In addressing the full spectrum of person-to-person, person-to-machine, and machine-to-machine applications the Little LEO system 'Leo One' has been designed to provide worldwide coverage specifically optimized for applications in those economies with the highest productivity and the highest concentration of machines.

Historically, the economics of terrestrial network infrastructure have focused deployment in areas of population concentration. For short data messaging, numerous urban networks exist in the U.S.A. and Europe. Similarly, the economics of satellite systems have supported the provision of service to lesser developed countries and rural areas, those markets considered to have the highest unmet demand due to a lack of traditional infrastructure. The unique performance capability resulting from the optimization of the Leo One architecture supports the provision of service in lesser developed regions as well as in the most developed markets. However, in general, the Leo One system will not compete with terrestrial data networks. It will pursue niche applications where characteristics of the service appeal to customers with particular attributes, such as multi-market coverage requirements when a single source solution is attractive or hybrid products enabling urban data networks to extend coverage nationally or even internationally. Copyright © 1999 John Wiley & Sons, Ltd.


The Two-Beam Accelerator (TBA) shows great promise for achieving high accelerating gradients, perhaps >250 MV/m, for such machines as electron linear colliders. This paper presents the results of studies of candidate structures for a TBA. Also, the hardware and program for 35 GHz high-gradient testing is described.


The article provides a theoretical analysis of scientific sources to highlight the essence and content of the formation of vocal and performing skills of the students majoring in art specialties; the existing scientific definitions of the concept "vocal-performing skills" have been investigated; the influence of pop songs on the formation of vocal and performing skills of the student has been determined; the efficiency of the offered techniques has been developed and experimentally checked. The purpose of the article is to determine the dynamics of growth of vocal and performing skills of the students majoring in art specialties under conditions of using pop songs at the lessons of voice training. General scientific methods of theoretical and empirical levels are applied: the analysis and generalisation of the theory and practice of pop singing; the study of advanced vocal and pedagogical experience in the field of vocal music education; the analysis of the author's pedagogical activity and its results; pedagogical observations; the survey of vocal teachers; the conversations with students and teachers; questionnaires; testing; interviews, etc. The basis of this technique is the pedagogical principles as follows: the principle of activating the interest and positive attitude of students to vocal lessons; the principle of protection and care for the singing voice; the principle of gradualness and consistency; the principle of availability and efficiency of the vocal repertoire; the principle of creativity; the principle of introducing elements of theatrical arts into the process of vocal education of students – future vocalists. The designated method involved the use of certain forms of learning (individual lessons, independent work, verbal form of learning, work on stage) and methods (methods of direct influence on muscular settings (vocal exercises, vocalisations, practice of technical elements of vocal work, explanatory-illustrative, reproductive, method of free associations, method of empathy, video method, method of master classes). The results of the formative experiment and comparative analysis of the obtained data have proved the effectiveness and efficiency of our proposed method aimed at forming vocal and performing skills of the students majoring in art specialties by means of pop songs.


Tin sulfide (SnS) thin films were produced on glass substrates at 65 °C by chemical bath deposition (CBD). Two of the obtained five identical films were annealed in an air atmosphere while the other two were annealed in a nitrogen atmosphere at different temperatures. The effects of annealing (at 150 °C and 250 °C in air and nitrogen atmospheres) on the optical, structural, and electrical properties of the films were investigated by UV-visible spectrophotometer, x-ray diffraction (XRD), Raman spectroscopy, scanning electron microscopy (SEM), and Hall-effect measurement. The energy band gap of as-deposited SnS thin film was determined to be 1.16 eV, and it was observed to change with annealing. All of the as-deposited and annealed SnS films had orthorhombic structures. The optical phonon modes to orthorhombic SnS phases were determined by Raman shifts. The carrier type of all SnS films was identified as p-type using Hall measurement, and the changing carrier concentration, mobility, and resistivity values of the films were investigated depending on annealing conditions. The p-type SnS film can be used as an alternative material for the absorber layer in p-n heterojunction solar cell applications.


PURPOSE: To provide a locking mechanism for surely performing locking even when the opening part of a housing case is deformed without being detached even at the carriage by engaging a planar locking member attached to the housing case with the locking member provided on a mounting base. CONSTITUTION: A locking mechanism 10 for freely detachably fixing a housing case 8 and a mounting base 4 is provided near the opening part and the locking mechanism 10 fixes the housing case 8 and the mounting base 4 by engaging a locking metal fitting 12 made of a sheet metal to be turned along the inner surface of the housing case 8 in linkage with an operation button 11 operable from the outside with a locking pin 13 provided on the mounting base 4. Also, the locking metal fitting 12 is provided parallelly to the wall surface of the mounting base 4 and is engaged with the locking pin 13 in the state of being inserted to a groove part 17. Even when the deformation or the like by external force of the wall surface of the housing case 8 occurs, since it is inserted to the groove part 17 and controlled and the moving direction is not the direction of releasing engagement with the locking pin 13, unlocking is not performed by the impact of the external force or the like. COPYRIGHT: (C)1989,JPO


This study was designed to investigate the growth and yield of protected tomatoes under the influence of biofertilizers, compost, and Humus. Two levels of bacterial fertilizer (S0 and S1), three levels of compost (C0, C1, andC2) t/ha-1, and three levels of Humus (H0, H1, and H2) kg/t. The traits of plant height, chlorophyll, vitamin C, and total yield were measured. The experiment was applied according to a Randomized Complete Block Design (RCBD) with three replications. The results present the efficacy of the treatment (S1 + C2 + H2) compared to the control treatment by resulting in the highest average of the studied traits: plant height, chlorophyll, vitamin C, total yield 109.50 cm/plant-1, 66.25 mg/100g-1 fresh weight, 29.23 mg/100ml-1*juice, 8.90 t/ha-1, respectively


Marital life has usually been almost unbearable for women in African fiction. During the last decades, their status has been changing very fast. In Beyond the Horizon by AmmaDarko, Mara, after having undergone maltreatment, carelessness and domination from her husband Akobi in Africa as well as in Europe, has ended up sending him to prison. This article attempts to explore how somefemale characters are endowed with the necessary courage to report the ill-treatment they have undergone to the right person or authority in order to take a revenge and have things changed for themselves. As pointed out by the study, Marahas proved that change must originate from her not from anybody else.
In order to be able to closely explore how Mara, as the embodiment of empowered women in the contemporary African fiction has improved (herself), it has been thoroughly evidenced such aspects as naivety, illiteracy and most importantly economic dependence of the female characters as the main factors working in an adverse way against them both in fiction and society.


Software-Defined Networking (SDN) relies on open programmability of network devices, which is achieved by defining new communication interfaces, network operating systems, and changing the traditional decision-making logic of regular TCP/IP networks. Network Functions Virtualization (NFV), in turn, permits virtualizing network functions that are traditionally performed by physical middleboxes (e.g., firewalling and intrusion detection/prevention). Although SDN and NFV improve the flexibility of the management of computer networks, SDN remains vulnerable to major network security problems, such as Distributed Denial of Service (DDoS) attacks. These attacks typically result in the disruption of network services and resources. In this paper, we introduce ANSwer, an architecture that combines NFV and SDN features to create sophisticated network resilience strategies. ANSwer relies on a feedback control-loop which explores SDN features to monitor and analyze the behavior of the network infrastructure, indicating whether parts of an existing resilience strategy can be reconfigured to achieve more satisfactory results, or if an entire resilience strategy needs to be added or replaced. Our experiments demonstrate that ANSwer can rapidly identify and handle distinct anomalies in different scenarios, indicating that the reconfiguration and deployment of resilience strategies can be performed in real-time.


In this paper, we propose a principle for improving the "bit duplication" method for designing rate-compatible low-density parity-check (LDPC) codes. An experiment was carried out in the Matlab to obtain codes of rate-1/4 with different variants for duplicating bits from the original irregular DVB-S2 code of rate-1/2. Experimental results show that different bit duplication variants give different performance, moreover, codes using duplication of that part of the code word, where, respectively, the columns of the check matrix have the majority of the nonzero elements, turn out to be the best.


The authors present research findings based on clinical case studies of biracial/bicultural adolescents. In presenting these findings, the authors have four goals: (1) to identify the major conflicts experienced by biracial and bicultural adolescents in mastering developmental tasks; (2) to delineate clinical and sociocultural issues in the assessment of these youth and their families; (3) to propose strategies of intervention for these youth; and (4) to suggest implications for clinical training and practice.


FTA apportions Section 5307 urbanized area (UZA) formula funds to census-designated UZAs. When UZAs contain multiple recipients of Section 5307 funds, FTA leaves it up to local officials to determine the suballocations to the multiple recipients. Little documentation exists on the question of how to allocate the funds on a local level. The more agencies within a UZA, the more complex the issue becomes. Local officials within the UZAs must develop methods of allocating funds that satisfy the desires of each of the regional stakeholders. The nature in which metropolitan areas grow leads to multiple transit agencies existing within the UZA and desiring access to UZA formula funds. This report identifies seven complex metropolitan areas across the United States with multiple Section 5307 fund recipients, identifies the problems experienced with allocating Section 5307 funds at the local level, and identifies three models of funding distribution techniques. The models of funding distribution include formula, formula and regional project selection, and regional project selection and local negotiations. Though only three models are identified, there is much variation within each model. The report provides details on the allocation within each region.


This work focuses its scope on the smooth contact approach and its management of multiple contact events, proposing several models developed under this methodology and discussing the main issues that have arisen when designing, modelling, and verifying them. The main purpose of this paper is to provide a reference to those researchers that work with smooth methods in the context of multibody dynamics of how to deal with them. Among the models presented, there are some engineering-focused ones, whereas the readers can also find some more practical, day-to-day examples.


One method for the absolute measurement of rate constants for defined quantum states is to study their response to sharply defined pumping. Such an experiment is the observation of the relaxation process after excitation of selected vibronic levels with amplitude modulated light. The observation could either involve secondary absorption or radiative emission. A general stochastic theory is formulated here for these time‐defined processes, in this case, undergoing vibronic relaxation and fluorescence emission. From the general transport matrix describing the relaxation problem via the master equation, the observables are an unambiguous consequence. The solution is given in a form suitable for direct computation. For this particular case, the theory predicts a phase angle in terms of a many‐shot expansion, which is not restricted to exponential fluorescence decay.


A lot of cases have been reported by Unani physicians in their literature where they shared about the miraculouseffect of Unani treatment in various diseases. When it comes to treatments of skin diseases this systemhas a lot to offer. Hikka (Pruritus) or Kharishkhushk is a skin disease that is characterized by Intense itchingwith rashes. One patient suffering from Hikka came to the hospital of the National Institute of Unani Medicine(NIUM), Bengaluru. He was treated in 10 days by using Unani medicines Alu Bukhara (Prunusdomesticus),Tamar Hindi (Tamarindusindica) and Shahtara (Fumeriaofficinalis) orally as well as Roghan Gul (Rose oil) andSirka (Vinegar) locally.


Book DOI: 10.21467/abstracts.93 With a total length of field pipelines of all types of about 220 thousand km the number of leaks in field pipelines only in 2018 was about 30 thousand or, on average, one leak per 7.1 km. According to the data provided by the Ministry of Energy of the Russian Federation, in 2018 there were 8,126 leakages with oil spills and environmental pollution in the amount of at least 1.0 million tons, of which 7,017 leakages in the oil pipelines (90 %) occurred because of corrosion. The social and economic damage is estimated at about 500 billion rubles. According to the Ministry of Natural Resources and Ecology of the Russian Federation estimation, the replacement of field pipelines should be 7-12% per year (about 20 thousand km), of the total length, and in fact 1-2% (about 3.0 thousand km) is replaced. This creates extremely unfavorable social and environmental conditions in the areas of oil production. The novelty of the proposed solution lies in the discharge of oil-field water directly on the well clusters or at a short distance from them by means of modular water treatment and injection facilities. This decision will significantly decrease the risk of environmental pollution by reducing the volume of pumped liquid, and reduce the load on the main oil treatment facilities and the number of vertical tanks. Electricity consumption for transporting water from treatment units to reservoir pressure maintenance system facilities are also significantly reduced. By discharging associated water near the wells, the length of the pipelines of reservoir pressure maintenance system is reduced from 24.8 km to 13.9 km, and metal consumption is reduced by 44%. Due to the reduced volume of pumped liquid, it becomes possible to replace existing pipes with polymer-metal pipes with a smaller diameter which will significantly reduce the metal consumption of field pipelines and the cost of their repair. The replacement of steel pipes with polymer-metal pipes will reduce the risk of the environment contamination as the low electrical conductivity of polymer materials included in the design of polymermetal pipes eliminates the possibility of stray currents in them and associated corrosion damage to the pipelines. There is no need for an electrochemical protection device, which also reduces the costs of both the proposed reconstruction and subsequent operating costs. The period of trouble-free operation of steel pipelines in aggressive environments is 3-5 years, and the accident rate reaches 30 or more accidents per 1 km per year. Polymer-metal pipes can be safely operated for 20 years or more. To ensure environmental safety it is necessary to have an automated system to control technological processes and technical condition of equipment and pipelines which is part of an automated field monitoring system. The monitoring system will allow to quickly influence technological processes, to control the dynamics of excessive pressure and temperature, the presence or absence of defects and on the basis of received information analysis to predict the occurrence of critical defects as well as the period of troublefree maintenance of pipelines and equipment.


Abstract— While studying the photoreduction of some dyes (D) by reducing agents (R), it was observed that the quantum yield of the photoreduction increases considerably upon addition of a third substance (C), whereas it is very small when the dye is photoreduced by C alone (catalytic effect), (see Table 1).


Subject
 South African infrastructure.

 Significance
 Building on previous government commitments to reverse the falling percentage of GDP spent on investment, last month's 2020 budget sought to rebalance government expenditure away from consumption spending to capital budgets. In a time of severely strained government finances and an economy in recession, Pretoria is looking to shift resources from stalled infrastructure projects to more viable ones and to attract private-sector investment.

 Impacts
 Eskom's new CEO could face growing public pressure to ease 'load shedding' (power outages) necessary for key plant maintenance.
 Ongoing bureaucratic, legislative and procurement hurdles will hamper improved infrastructure spending over the short term.
 A flagship government aim for 30% of GDP to be spent on investment by 2030 is unlikely to be realised.


Short-and long-term attributable costs of Clostridium difficile-associated disease in nonsurgical inpatients". (See the editorial commentary by Paladino and Schentag on pages 505–6) Background. The incidence of Clostridium difficile–associated disease (CDAD) is increasing. There are few data on the short-term and long-term attributable costs of CDAD. The objective of this study was to determine the acute and 180-day attributable inpatient costs of CDAD. Methods. We performed a retrospective cohort study of all patients without operating room costs who were admitted for у48 h to Barnes-Jewish Hospital, a tertiary care hospital in St. Louis, Missouri, 1 January 2003–31 December 2003 (). Attributable costs of CDAD were determined by multivariable linear regression and n p 24,691 propensity-score matched-pairs analyses () for the hospitalization in which CDAD occurred and per patient n p 684 over a 180-day period, including the initial hospitalization. attributable costs per CDAD episode by linear regression and with $3240 attributable costs (; increase in P ! .001 cost, 33%) by propensity-score matched-pairs analysis. CDAD was associated with $5042 (95% confidence interval, $3797–$6481; increase in cost, 53%) attributable inpatient costs over 180 days by linear regression and with $7179 attributable costs for inpatient care (; 48% increase in costs) by propensity-score matched-pairs analysis. P ! .001 Conclusions. CDAD was associated with a significant increase in costs for inpatient care and increased costs at 180 days after the initial hospitalization when the CDAD episode occurred.


Gaining Competitive Advantage with Knowledge Management Gaining Competitive Advantage with Strategic Intelligence Gaining Competitive Advantage with Globalization Gaining Competitive Advantage Through E-Learning Gaining Competitive Advantage Through Social Networking Gaining Competitive Advantage Through Virtual Worlds Gaining Competitive Advantage Through Technology Gaining Competitive Advantage Through Human Capital Gaining Competitive Advantage Through Relationships Gaining Competitive Advantage Through Innovation Index


An iterative domain decomposition method is proposed for numerical analysis of 3-Dimensional (3D) linear magnetostatic problems taking the magnetic vector potential as an unknown function. The iterative domain decomposition method is combined with the Preconditioned Conjugate Gradient (PCG) procedure and the Hierarchical Domain Decomposition Method (HDDM) which is adopted in parallel computing. Our previously employed preconditioner was the Neumann-Neumann (NN) preconditioner. Numerical results showed that the method was only effective for smaller problems. In this paper, we consider its improvement with the Balancing Domain Decomposition DIAGonal scaling (BDD-DIAG) preconditioner. Specially, the coarse matrix solver is changed to an iterative solver and numerical results show that the incomplete CG iterative solver like CG(10) is more effective than the standard approach.


This article examines the role of technology in Ray Bradbury's Fahrenheit 451 and a selection of his short stories (including "The Murderer" and "The Pedestrian") with an emphasis on Bradbury's views on overreliance on technology. Bradbury's views on technology are complex and multifaceted, and his works explore the philosophical questions raised by a dependence on an increasingly technological world. Bradbury's works caution against the dangerous repercussions of overuse of technology and the way in which individuals are often manipulated by it. The article examines the application of Bradbury's ideas in the modern world and his views on technology's effect on literacy and attention span, exploring Bradbury's views on individual autonomy, and common themes within his work including dystopia, paranoia, and technological overreach. The article also examines Bradbury's interviews and modern critical evaluations of the themes discussed, identifying commonalities within those themes. It seeks to evaluate the modern application of the ideas and themes discussed in Bradbury's stories, and how those themes have evolved and continue to be relevant as technology progresses.


To support the General Administrative Order on Construction Materials (Soil and Surface Waters Protection) this document supplies information on: 1) the quantification of the standard values for the application of construction materials ; 2) the environmental quality (characterization) of construction materials ; ; 3) the consequenses for use and re-use of construction materials.


The production of pure ethanol apparently begins in the 12 - 14 th century. I mproveme nts in the distillation process with the condensation of vapors of lower boiling liquids. Ethanol is produced commercially by chemical synthesis or biosynthesis. High ethanol producing yeast exhibits rapid metabolic activity and a high fermentation rate wi th high product output in less time. Yeasts were isolated from Corn , Curd , Grapes, Water 1, Water 2, and Paneer . Isolation was done on MGYP (Malt Extract Glucose Yeast extract Peptone) media . Contamination was less in selected media. Grape sample yeast was observed as high in producing ethanol after optimization in jaggery broth. Curd yeast gives 4.6% alcohol by volume alcohol (a.b.v) after fermentation . P aneer yeast gives 2.88% alcohol by volume alcohol (a.b.v) after fermentation. C orn yeast gives 5.25% (a .b.v) alcohol after fermentation Water - 1 yeast gives 5.51% (a.b.v) alcohol after fermentation.W ater - 2 y east gives 4.98% (a.b.v) alcohol after fermentation.


The transcription factor nuclear factor-κB (NF-κB) is critical for the induction of inflammatory responses in T-cells, survival and differentiation. Antigen receptor (TCR) and co-receptor CD28 are the central regulators of NF-κB activation in T-cells. Progress in understanding NF-κB activation in T-cells has occurred over the years with the identification of individual adapters such as ADAP and GRB-2 and enzymes such as PKC-θ that regulate NF-κB. However, little is known whether the engagement of distinct modules by the TCR and CD28 account for the cooperative effects of the two receptors in activating NF-κB. In this review, we discuss recent advances in our understanding of NF-κB regulation by TCR and CD28.


We show how the dynamic logit model for binary panel data may be approximated by a quadratic exponential model. Under the approximating model, simple sufficient statistics exist for the subject-specific parameters introduced to capture the unobserved heterogeneity between subjects. The latter must be distinguished from the state dependence which is accounted for by including the lagged response variable among the regressors. By conditioning on the sufficient statistics, we derive a pseudo conditional likelihood estimator of the structural parameters of the dynamic logit model, which is simple to compute. Asymptotic properties of this estimator are studied in detail. Simulation results show that the estimator is competitive in terms of efficiency with estimators recently proposed in the econometric literature.


Munich. The BMW Museum. As if it isn't good enough on its own, BMW is about to stage a "Night of the White Gloves" for the fourth time. On 25 November from 19h to midnight, for a 5,00 € entry fee, visitors will be given white gloves and the opportunity to touch, stroke and grope 95 years of…


ABSTRACT The nature of [(C7H7N2)3(NH4)]2[Mo8O26]2·4H2O intermolecular interactions has been analysed through Hirshfeld surfaces and 2D fingerprint plots. So it is explicit that presence of amine groups and water molecules reveals that O···H/H···O intermolecular interactions are the most abundant contacts in the crystal packing. Semi-empirical calculation has been done to study the theoretical properties of this polyoxometalate compound. In this study, we have investigated several properties such as frontier molecular orbital, molecular electrostatic potential, electron density, thermodynamic properties, dipole moment, QSAR properties and local ionization potential. This work provided helpful information for the study of electronic structure and molecular properties.


Begin with intrusion technology analysis,this article briefly summarizes main current intrusion detection technologies and intrusion detection system(IDS).It also prospects the trends of IDS.And it proposes the conception of a new intrusion management system(IMS) based on intrusion management which leads a new way to the next study of IDS in future.


This paper presents an implementation of a LEON3-based System-on-Chip (SoC) testbed, which is aimed at experimentally evaluating and validating the H.264/AVC video encoding Integrated Circuit (IC) developed by SIS Laboratory at VNU University of Engineering and Technology. In addition, the paper also presents a methodology for verifying the design of H264/AVC video encoder in the Hardware/Software co-emulating fashion. The design is implemented on the DE2 development board from Altera Corporation. The testbed can help us to evaluate effectively many aspects of the developed H.264/AVC video encoder.


In this paper, the nozzle design with asymmetric configuration using the optimal method is used in order to improve the under- and over-expansion problem of the flow at the supersonic turbine nozzle. For the design of nozzle contour, 8 design variables are selected and the total-to-static efficiency from the nozzle inlet to the wake outlet is considered as the objective function to be maximized. The Fluent6.3 and the iSIGHT-FD program are used for calculation of nozzle flow and design optimization respectively. RBF(Radial Basis Function) method is chosen for approximate optimization algorithm. It is shown that the static efficiency of improved nozzle design increases 1.35% and loss coefficient decreases 19.85% as compared to baseline design.


Plasmids, YEp13 and pMA56, were encapsulated Into liposomes by two different procedures during which the plasmid DNAs were exposed ether to 6 for 1.5 hr or to sonication for 2-5 min at 4. The encapsulated plasmids were then reextracted and their physical conformations and transformation abilities were examined. It was confirmed from the results that both plasmid DNAs were remained stable throughout the procedures of encapsulation into 1iposomes.


Crowdfunding enables the organizing of support for victims of a tragedy from a wide range of sources. While this support can be financial and non-financial, we know relatively little about the non-...


The rationale of the therapy of tinea capitis with estrogens is based on an observation of the tendency toward spontaneous cure at puberty and the rarity of the disease in adults. Physiologic evidence of estrogen production before puberty is insignificant, and the development of the adult type of cell in the vagina in children has been repeatedly demonstrated as the result of estrogenic therapy. These considerations prompted the organization of a clinic for ringworm of the scalp in July 1940 at the Robert B. Green Memorial Hospital to determine the effect of estrogen therapy on tinea capitis. The multiplicity of drugs and procedures used heretofore in the treatment of tinea capitis has precluded, in general, the use of any single routine therapeutic procedure. Epilation has perhaps been the most uniform method of treatment, and even this has subjected children to hazardous methods, such as the use of thallium acetate or


The paper analyzed the variation charateristies of the global solar radiation in Haikou using sun bolometric radiation and the meteorological data from 1971 to 2008 which came from seaport ground station of Haikou.The results indicated that sun radiation reduced by-248.467MJ/m2.a,the month variation was consistent with the annual variation tendency.The low cloud amount and aqueous vapor tension were the main influencing factors.The significance of relationships between the global solar radiation and the temperature was remarkable at 0.001 level.


This study investigates the possible relationship between changes in monsoonal (May–June) rainfall diurnal variations over the south China coast and urban surface processes using hourly rain gage data during 1981–2014 and semi‐idealized numerical simulations. The continuous landward penetration of regional climatic rainband observed prior to urbanization is blocked by the city. The morning precipitation initiated at the coast "jumps" to the downstream area of city in the late afternoon, causing a 2 hr delay of the rainfall peak time. Simulations clearly reproduce this change by turning off/on the urban land use, and demonstrate a direct connection between the change of rainfall diurnal variations with a magnitude‐enhancing but slower‐penetrating sea breeze as well as the thermodynamic conditions modified by the city. Individual impacts of sensible heating, evapotranspiration, and friction from urban surface are examined using various sensitivity experiments. Urban sensible heat is found to act as the energy source to enhance the sea breeze and induce the asymmetric low‐level urban inflow that blocks the penetration of sea breeze and changes the rainfall location. Evapotranspiration and latent heat flux suppressed by the impervious urban surface causes a drier boundary layer and lower CAPE over the city. The "jumping" of the climatic rainband may result from the competing interaction of the dynamic and thermodynamic factors. Urban friction has little impact on the daytime rainfall, but could slow down seaward wind speed and enhance coastal convergence in the early morning if no strong urban heat island is present.


We report some recent developments in the understanding of GRBs based on the theoretical framework of the "fireshell" model, already presented in the last three editions of the "Brazilian School of Cosmology and Gravitation." After recalling the basic features of the "fireshell model," we emphasize the following novel results: 1) the interpretation of the X‐ray flares in GRB afterglows as due to the interaction of the optically thin fireshell with isolated clouds in the CircumBurst Medium (CBM); 2) an interpretation as "fake—disguised" short GRBs of the GRBs belonging to the class identified by Norris & Bonnell; we present two prototypes, GRB 970228 and GRB 060614; both these cases are consistent with an origin from the final coalescence of a binary system in the halo of their host galaxies with particularly low CBM density ncbm∼10−3 particles/cm3; 3) the first attempt to study a genuine short GRB with the analysis of GRB 050509B, that reveals indeed still an open question; 4) the interpretation of the GR...


This paper used a large nationally representative longitudinal dataset to explore the association between changing socioeconomic factors and household consumption of life insurance across time. This study specifically examined the association between changes in wealth and life insurance consumption controlling for household characteristics and psychosocial factors. Empirical results indicate that during the 2004-2008 period, an increase in net worth was positively associated with purchases of additional cash value life insurance at the household level. Women and Black households were also more likely to increase their life insurance consumption during this period. Saving intention was likewise found to be positively associated with an increase in household life insurance consumption. Results suggest that life insurance acts a complement to, rather than substitute for, wealth. Implications of the findings of this study for individual investors, scholars and practitioners have been included. Introduction Life insurance consumption, and the factors associated with the demand for life insurance, is among the most studied topics in the general business domain. As a result, much is known about the causal triggers of life insurance consumption and the macroeconomic mechanisms that alter the use of life insurance in different marketplaces. Li, Moshirian, Nguyen, and Wee (2007), for instance, noted that governmental expenditures on social insurance programs tend to be inversely related to life insurance demand. They reported that consumers living in markets where social welfare programs are broad and extensive in coverage tend to have reduced costs associated with unexpected death. As such, social welfare tends to act as a substitute for private market life insurance coverage. Single-period macro-viewpoint studies using social welfare data offer intriguing insights into insurance consumption patterns. Again, consider the work of Li et al. (2007). Their observation that social welfare expenditures, at the governmental level, are negatively related to life insurance demand are premised on a key assumption; namely, "social security expenditure is a proxy for national wealth" (p. 641). They went on to state that when viewed holistically, selfinsurance (i.e., direct purchase of life insurance) can be substituted with wealth. That is, as wealth increases, the demand for life insurance should fall. However, their insight was based entirely on international macroeconomic data comparisons where wealth was measured using social welfare expenditures as a proxy for country wealth. Two ancillary questions come to mind Life Insurance Consumption 2 in the context of the insurance-wealth connection. The first asks if household wealth also acts as a substitute for self-coverage. The second asks if life insurance, at the household level, acts as a complement, rather than a substitute, for wealth. Surprisingly, there have been few attempts to address these questions directly. Zietz (2003) reviewed 12 studies that explicitly examined the association between wealth (i.e., net worth) and the demand for life insurance. While the majority found a positive association between consumption of life insurance and wealth, the findings were not consistent. Some researchers noted a negative association, while others found non-significant relationships between demand for life insurance and wealth. Mossin (1968) wrote what has since become the seminal piece on the wealth effect and insurance consumption. He found that wealth was associated with risk aversion. Although not necessarily causally related, he noted that consumers who exhibit higher household wealth tend to accept higher levels of financial risk. The implication being that wealth and risk aversion may, indeed, be related to life insurance consumption, with the wealth-insurance association being negative when risk aversion is controlled. Fischer (1973) noted that household wealth appears to act as a form of self-insurance, thus reducing the demand for life insurance over time. To make matters even more confusing, others, including Eisenhauer and Halek (1999), have also noted a relationship between wealth and risk aversion, but concluded that wealthier households are more likely to own life insurance. Their findings suggest the possibility that insurance is more of a complementary, rather than a substitute, good. It also is possible that life insurance consumption decisions are not independent and that wealthy consumers may be just as likely to purchase life insurance as low wealth consumers (Mayers & Smith, 1983) and vice-aversa. The purpose of this paper is multifaceted. The first objective involved testing the wealthinsurance association using household, rather than macroeconomic, data. The second purpose was to evaluate the demand for life insurance as a function of changing socioeconomic factors over time rather than viewing the demand for life insurance on a cross-sectional basis. The third objective entailed the inclusion of saving intention and risk aversion as possible covariates, with wealth, as factors explaining the demand for life insurance. The research reported in this paper adds to the existing literature by showing that Li et al.'s (2007) assertion that the consumption of life insurance declines as wealth increases may only be true at a macroeconomic level. Rather Life Insurance Consumption 3 than being a substitute for wealth, life insurance may act more like a complementary good when household data is examined. Review of Literature As mentioned in the introduction to this paper, much is already known about the factors associated with the demand for life insurance. Rather than reviewing this literature extensively, the following discussion highlights some of the key findings from the existing body of knowledge. Readers who are interested in a more comprehensive and historical review of the demand features of life insurance are encouraged to read a summary piece written by Zietz (2003). In her manuscript, Zietz provides one of the most comprehensive overviews of the key variables that have been tested as possible determinants of the demand for life insurance products. The key takeaway from her work is that little consensus exists among researchers, over time, as to what factors cause the consumption of life insurance to change, or when a variable is found to be important in explaining demand, how stable the relationship remains over time. As an example, much of the early life insurance literature points to household size as being a key factor shaping life insurance consumption. The original thought was families with many dependents would find the loss of a breadwinner's income to cause economic hardship, thus increasing life insurance consumption among larger households (e.g., Berekson, 1972; Burnett & Palmer, 1984). While generally true, it is possible to find a few studies that show household size to be negatively associated with insurance demand (e.g., Auerbach & Kotlikoff, 1989), whereas other papers have been published showing no association between household size and life insurance demand (e.g., Anderson & Nevin, 1975; Duker, 1969). What this reveals is the intense interest among researchers to understand and explain life insurance consumption patterns on the one hand, but also, on the other hand, the existing need to more accurately define the determinants of life insurance consumption. Wealth and Life Insurance Human capital theory provides a starting point in the wealth-insurance discussion. According to Chen, Ibbotson, Milevsky, and Zhu (2006), consumer wealth is comprised of two elements: financial assets and human capital. Human capital is generally defined as the present value of all future labor income. Theory suggests that consumers allocate resources presently to maximize both current and future consumption. In some respects, financial and human capital are substitute assets. That is, younger consumers tend to possess fewer financial resources (i.e., Life Insurance Consumption 4 they have a low net worth) because they have had fewer years to amass financial wealth. On the other hand, consumers at the beginning of their careers generally have higher human capital than others. Over time, the relationship between financial wealth and human capital wealth tends to shift. Theoretically then it is logical for those with a low financial wealth to human capital wealth ratio to own life insurance as a way to hedge a loss in human capital. Those who exhibit greater wealth ought to be, theoretically and holding bequest motives constant, less likely to demand life insurance. Although few studies have framed life insurance consumption issues in a human capital framework, there is some evidence to suggest that the wealth-insurance demand choice is negative (Lewis, 1989). Hau (2000), on the other hand, noted, using data from the Survey of Consumer Finances, that wealth was positively associated with insurance demand. However, some of the demand in his study might have been attributable to a need among very wealthy and older households to obtain estate liquidity to fund tax liabilities and charitable bequests. As a way to partially address this potentiality when identifying the demands for life insurance, this research attempts to minimize the effect of outliers in wealth and age-based bequest motives by delimiting the analysis to respondents age 43 and 51 in 2008 and adjusting net worth to reflect changes in wealth over time periods. In effect, this analytical approach alters the debate from hinting that absolute financial wealth determines life insurance demand to one suggesting that changes in wealth may also be an important trigger in changing life insurance consumption. This framework matches more closely with Li et al.'s (2007) notion that increases or decreases in wealth, rather than absolute levels of wealth, relate to life insurance demand. Income and Life Insurance


Objective To investigate the value of ultrasound diagnosing for hydropneumothorax. Methods In a prospective double-blind concurrent controlled trial. 213patients doubted pneumothorax were examed with CT,sonography and conventional radiography. Results In 213 cases ,hydropneumothorax diagnosed in 30 hemithoraces of 30 patients by CT, 29 hemithoraces by ultrasound and 22 hemithoraces by X-ray. The sensitivity, negative predictive value, accuracy by ultrasound and X-ray were 96.7% with 73.3%, 99.8% with 98.0%, 99.8 with 98.1% in order(P0.05), the specificity and positive predictive value of both ultrasound and X-ray were 100%.Ultrasound surpassed the X-ray In detecting pneumothorax。 Conclusion If ultrasound is served to detect pneumothorax ,that can make up the defects of the methods commonly used currently.


Most mature balsam fir trees (Abies balsamea (L.) Mill.) growing at the top of Mount Megantic (Quebec) exhibit multiple leaders in the upper crown section, an indication of stressful conditions for tree development in this high-altitude stand. We report here on a detailed dendroecological analysis of windthrown trees showing that multiple stem development was linked to spruce budworm activity during the 1970s. In spite of severe defoliation, damaged trees temporarily restored their vegetative structure by forming reiterated axes. About 9% of all leaders sampled died during a 3-year period (1996-1998), which represents 60% of dead leaders sampled, with tree morbidity and mortality also peaking in 1996. Tree-ring dating of growth anomalies indicated the impact of major snow and (or) ice storms during the 1996 and 1998 winters, two events validated by field observations from the Mount Megantic conservation area authorities. Biotic (defoliators) and extreme climatic events have a combined influence in the dyn...


Stomatin‐like protein 1 (STOML1) was found both at the plasma membrane and associated with vesicles in the neurites of dorsal root ganglia (DRG) neurones. We found that STOML1 modulates ASIC1a and ASIC3. In the presence of STOML1 acid gated currents carried by ASIC1a were decreased and ASIC3 currents showed accelerated inactivation; STOML1 had no effects on other ASICs. Among the stomatin family, only STOML1 has a sterol carrier protein‐2 domain and removal of this domain prevented inhibition of ASIC1a currents. We generated a mouse with a β‐galactosidase‐neomycin cassette gene‐trap reporter driven from the STOML1 gene locus to demonstrate that STOML1 is expressed by approximately half of all DRG neurones. Whole‐cell electrophysiology recordings from DRG neurones from STOML1 null mutant mice showed on average larger proton‐gated currents compared to neurones from wild‐type mice.


In this work, novel derivatives based on 3-cyano-6-naphthylpyridine scaffold were designed and synthesized as potential kinase inhibitors and cytotoxic agents. The cytotoxic activity data indicated that all the 56 newly synthesized compounds exhibited high activity against prostate cancer cell lines PC3 and DU145 and breast cancer cell lines MCF7, MDAMB435 and BT549 in nanomolar range. The in vitro results were confirmed by further examination of the most active compounds in vivo in PC3 and MCF7 xenograft models where they displayed a remarkable reduction in tumor growth. Finally, kinase inhibition assay results revealed that all compounds showed good inhibitory activity against both VEGFR-2 and EGFR. These research findings indicate that these compounds act as cytotoxic agents at various interplay levels of activities.


Autonomous robotic vehicle are robots which can perform certain desired tasks in a dynamic environment without human guidance to a certain degree. Most autonomous robots rely heavily on readily available off-the-shelf sensors to perform navigation. The research published here shows a glimpse of an innovative application of image processing in future robotic vehicles, which are capable of making their own decisions to avoid obstacles and plan its path in order to be truly autonomous in navigating dynamic environments. Our low cost Autonomous Robotic Vehicle (AutoRoVe) is competent of avoiding obstacles and mapping its path and move ahead using laser-beam assisted vision control system that is well capable of navigating uncharted territories. The system comprises of a an onboard 1GHz Via C3 processor with a mini-ITX motherboard and 512MB of RAM, a USB colour camera and laser tracking system that demonstrates the flavour of self navigating capability that future mobile robots may have.


The courtyard garden represents a constant feature of domestic architecture in most Muslim regions; however, it was developed in different ways as influenced by many local factors. Its organization, configuration and social role, suggest more a sociocultural need than a physical one. Therefore, it is important to base them on this ground rather than the climatic argument. The method of content analysis and library search has been adopted in this study. To conclude, to ensure the existence of courtyard gardens, it is important to think courtyards as a social space able to adapt to the changing conditions of modern life, anywhere in the world to ensure a continuous link between history and the present day.


The observed shift of the core of the relativistic AGN jets as a function of frequency allows us to evaluate the number density of outflowing plasma and, hence, the magnetization parameter. New analysis of more than 20 sources shows that for most of jets the magnetization parameter ~ 10 - 100. Since the magnetization parameter is the maximum possible bulk Lorentz-factor of the relativistic flow, this estimate is consistent with the observed superluminal motion.


With the new "Labor Contract Law" promulgation and implementation,many non-standard employment way in the university library will face a lot of legal risks,the principle of "equal pay for equal work" is not well implemented;temporary employment ingores employment quantity scale and position limits;labore concract review mechanism is not established.The author analyses lastest revision of "Labor Contract Law",makes research on legal risk of university library labor employment and puts forward countermeasures.


The global demand for medicinal plants is growing rapidly, and to meet this demand, commercial cultivation of the plants is needed. However, traditional cultivation methods result in varying levels of biomass production as well as active content variation. Hydroponic farming can be used to produce medicinal plants with superior quality, more biomass output, and higher concentrations of bioactive substances. This system plays an important role in improving the therapeutic value of medicinal plant species.

Keywords: Hydroponic, medicinal plants, cultivation, bioactive compounds.


We address two principal difficulties of multi-target tracking in a real traffic scenario. Firstly, fast moving traffic scenarios lead to large displacements and complex interactions with occlusions and ambiguities. Secondly, the tracking application for real traffic scenarios has the online requirement. To surmount these difficulties, we propose an approach to track the multi-target online by Boosting and scene context reasoning. To this end, we use a two-stage system, where the first stage learns a non-linear classifier which is capable of generating the observation similarities. In the second stage, we demonstrate a novel relationship between observations and the scene layout parameters. Using a probabilistic formulation and the above relationship, our method has the unique ability to handle exceptions. To evaluate our method, we create three real traffic data sets, covering urban, rural, and highway conditions. We hope that these datasets will push forward the performance of tracking systems when being moved outside the laboratory to the real world.


Biography Dr. Mira Kallio-Tavin is Associate Professor of Arts-based Research and Ped-agogy and the Head of Research in the Department of Art at Aalto University, Finland. Kallio-Tavin has developed arts-based research methodology within social context and in relation to the questions of dialogue, community, ethics and philosophy of contemporary art and its education. Her research area fo-cuses on questions of diversity, disability studies, social justice, critical animal studies, embodiment, and art education beyond anthropocentricism, including perspectives from "more than human" and critical issues from the perspectives of "less than human". Professor Kallio-Tavin serves as a World Councilor of InSEA (International Society for Education Through Art), and as the Chair of Disability Studies in Art Education (DSAE) interest group in the NAEA (National Art Education Association) in the United States. She is the founder of the International DSAE conference, and the founder of Nordic Visual Studies and Art Education (NoVA) is the author and editor of six books, and editor of journals Research in Art and Education (the chief editor) and The International Journal of Education through Art (editor).


At water reclamation facilities, recycling of nutrients (nitrogen and phosphorus) from solids‐handling processes to the mainstream treatment process can have detrimental effects on biological nutrient removal systems. In this study, mass fluxes of nitrogen and phosphorus were quantified through the treatment trains at the Northwest Regional Water Reclamation Facility (NWRWRF) and the adjoining Biosolids Management Facility (BMF), which receives sludge from several water reclamation facilities in Hillsborough County, Florida. The driving objectives were to determine (a) whether the return stream from BMF to NWRWRF (i.e., the "sidestream") represents a significant source of nitrogen and phosphorus to NWRWRF, and (b) whether the sidestream return from BMF is interfering with biological nutrient removal processes at NWRWRF. We determined that nearly half of the overall phosphorus flux into NWRWRF is recycled from the BMF sidestream. This leads to an increased cost of treatment, for example, for alum used in phosphorus removal at NWRWRF. In contrast to phosphorus, the flux of nitrogen from BMF to NWRWRF is small (~3%) compared with the flux of nitrogen entering NWRWRF in raw wastewater. However, nitrogen in the sidestream is mostly in the form of nitrate, which prevents anaerobic conditions from developing in the fermentation basin at NWRWRF, and thereby interferes with the enhanced biological phosphorus removal (EBPR) process. Some measurements suggest that fermentation and release of phosphorus may occur in the return activated sludge line (despite the relatively short residence time in that line), which supports EBPR and may partially compensate for anoxic (denitrifying) conditions in the fermentation basin. Therefore, overall, NWRWRF is able to meet its permit limits for phosphorus through a combination of EBPR and alum addition. Although the fluxes measured here are particular to the treatment systems under consideration, the general trends observed are likely to apply to many similar facilities that employ biological nutrient removal, aerobic digestion, and sidestream recycle, particularly those with regional biosolids management facilities. We recommend that such facilities consider (a) removal or recovery of phosphorus from their sidestreams and (b) returning sidestreams downstream of fermentation basins to avoid inhibition of EBPR processes.


A 56-year-old male with metastatic unresectable cholangiocarcinoma presented to our clinic with worsening nausea and vomiting. Prior to presentation, the patient underwent placement of a palliative metal biliary stent and an uncovered self-expandable metal stents (UCSEMS) through the pylorus and duodenum for gastric outlet obstruction (GOO) from tumor burden. However, the patient subsequently developed a repeat duodenal obstruction from tissue ingrowth and had a second UCSEMS deployed within the first stent 6 months after the original stent placement.


This fascinating work is a summing up of Dr. John Money's clinical experience and research on the frontiers of human sexuality. Written in response to the current lack of a fully recognised science of sexology and full-service sexology clinics, Money gives professionals and lay persons alike the techniques for recognising the 'unspeakable monsters' of sexual disease that lurk behind many physical and mental problems. Money contends that sexually related diseases like AIDS and sex crimes such as child abuse, rape, and serial murder will continue to wreak havoc in society until we learn to deal scientifically with the sometimes disturbing realities of sexuality. Using case studies and well-known examples, the author proposes five universal human needs and three categories of coping strategies where major sexual problems find pathological camouflage to elude detection and treatment, often until it's too late.


Lenalidomide is approved for the treatment of Low and Intermediate-1 risk International Prognostic Scoring System categorized myelodysplastic syndromes (MDS) with deletion (del (5q)), and has an evolving role in other subtypes of MDS. Severe cytopenias may emerge with lenalidomide treatment, which appear to be related to elimination of the dysplastic clone. Although guidelines based on expert opinion have been published, the optimum management of lenalidomide-induced cytopenias in MDS in the "real world" setting is still evolving. We report two illustrative cases of lenalidomide-induced cytopenias in patients with del (5q) MDS, present an updated review of the literature and provide practical guidance for the management of cytopenias during lenalidomide treatment of MDS.


Prof. Tsung O. Cheng, MD, Division of Cardiology, George Washington University Medical Center , 2150 Pennsylvania Avenue NW, Washington, DC 20037 (USA) Dear Sir, I read with interest the article by Shahar et al. [1] on the disappearance of Dressier's syndrome following the introduction of thrombolysis therapy for acute myocardial infarction, but the decrease in incidence or near disappearance of Dressier's syndrome has been reported by previous observers [2, 3] before the era of thrombolysis. In contrast to the 3-4% reported originally in 1959 by Dressier [4], in 1982, Lich-stein et al. [2] did not find one single case in a retrospective study of 229 patients treated in the same institution as Dressler's patients. Therefore, I propose that the near disappearance of Dressler's syndrome is more likely related to the decreased use of oral anticoagulants and to more aggressive treatment of early postmyocardial infarction pericarditis [2, 3] than to the advent of thrombolytic therapy [1]. References Shahar A, Hod H, Barabash GM, Kaplinsky E, Motro M: Disappearance of a syndrome: Dressler's syndrome in the era of thrombolysis. Cardiology 1994;95:255-258. Lichstein E, Arsura E, Hollander G, Greengart A, Sanders M: Current incidence of postmyocardial infarction (Dressler's) syndrome. Am J Cardiol 1982;50:1269-1271. Braunwald E: Heart Disease, ed 4. Philadelphia, Saunders, 1992, p 1263. Dressier W: The postmyocardialinfarction syndrome. A report on forty-four cases. Arch Intern Med 1959;103:28-42.


relevant insights into Bronze Age spiritual beliefs and concepts of supernatural powers, preserved in some form of shadowy continuity, albeit dynamic, over the two thousand years that separate them from the composition of the poems and sagas. This position is problematic, to say the least, particularly since many scholars regard these texts as unreliable sources even for the Viking Age that they claim to describe, at a temporal remove of a 'mere' two or three centuries. The difficulties with this view emerge more clearly when one considers the third strand of Kaliff 's argument, his putative Indo-European context.


The Nan\c{c}ay Radioheliograph (NRH) routinely produces snapshot images of the full sun at frequencies between 150 and 450 MHz, with typical resolution 3 arcmin and time cadence 0.2 s. Combining visibilities from the NRH and from the Giant Meterwave Radio Telescope (GMRT) allows us to produce images of the sun at 236 or 327 MHz, with a large FOV, high resolution and time cadence. We seek to investigate the structure of noise storms (the most common non-thermal solar radio emission). We focus on the relation of position and altitude of noise storms with the observing frequency and on the lower limit of their sizes. We present results for noise storms on four days. The results consist of an extended halo and of one or several compact cores with relative intensity changing over a few seconds. We found that core sizes can be almost stable over one hour, with a minimum in the range 31-35 arcsec (less than previously reported) and can be stable over one hour. The heliocentric distances of noise storms are $\sim 1.20$ and 1.35 $R_{\odot}$ at 432 and 150 MHz, respectively. Regions where storms originate are thus much denser than the ambient corona and their vertical extent is found to be less than expected from hydrostatic equilibrium. The smallest observed sizes impose upper limits on broadening effects due to scattering on density inhomogeneities in the low and medium corona and constrain the level of density turbulence in the solar corona. It is possible that scatter broadening has been overestimated in the past, and that the observed sizes cannot only be attributed to scattering. The vertical structure of the noise storms is difficult to reconcile with the classical columnar model.


Abstract The synthesis of phosphine‐based functional covalent organic frameworks (COFs) has attracted great attention recently. Herein, we present two examples of triphenylphosphine‐based COFs (termed P‐COFs) with well‐defined crystalline structures, high specific surface areas, and good thermal stability. Furthermore, rhodium catalysts with these P‐COFs as support material show high turnover frequency for the hydroformylation of olefins, as well as excellent recycling performance. This work not only extends the phosphine‐based COF family, but also demonstrates their application in immobilizing homogeneous metal‐based (e.g., Rh‐phosphine) catalysts for application in heterogeneous catalysis.


Much of the housing that low-income people can find is substandard in that it doesn't meet modern fire and other safety codes. Because it doesn't meet housing codes, it is often shut down and taken off the market. This wellintentioned policy has the unfortunate effect of reducing the supply of housing for low-income people, forcing them into worse alternatives such as remaining in abusive situations, staying in temporary shelters, living under bridges, forming illegal campsites, sleeping in doorways, etc.


The internal causes of latent-crimp were analyzed bystudying the supermolecular structures of the standardpolyester fibers(PET),copolyester fibers(IPET)andtheir side-by-side composite fibers(PET/IPET)inthis paper.It is concluded that IPET and PET/IPEThave better latent-crimp ability because of their asym-metric supermolecular structures.At the same time,they have good dyeability and mechanical properties.Soit is a simple and low cost process to manufacture latent-crimp continuous fibers by melt-spinning of the co-polyester IPET.


Set in the author's adopted home of California in the 1920s, this is Gene Stratton-Porter's last novel, a story filled with wisdom, a love of nature, and her own abiding optimism. In it a Master Bee Keeper, his bees, and the natural beauty of California restore a wounded World War I veteran to health.


The notion «pupils' healthkeeping individual experience » and its components are defined. Potential of space and subjects, social, psycho-didactic components of school educational environment in pupils' healthkeeping individual experience formation is revealed. The subjects' functions of pupils' healthkeeping individual experience formation while implementing «Grant health to yourself» complex program are described.


ABSTRACT In situ fossil barnacle populations (Cirripedia, Balanomorpha) are described from the Miocene Natori Group of the Moniwa-Goishi area, northeast Japan. The Natori Group exhibits a transgressive sequence from subaerial lavas and volcaniclastics (Takadate Formation) to shoreface-shelf deposits (Moniwa and Hatatate formations) in ascending order. In the Takadate Formation, volcaniclastics locally intercalate bay deposits in which the fossil barnacle Balanus bisulcatus occurs on gravel surfaces in situ. The Takadate Formation is unconformably overlain by the basal conglomerate of the Moniwa Formation, which is interpreted as a ravinement deposit formed in an open coast. An extinct barnacle species, Concavus sendaicus, is found as gregarious clusters and solitary individuals on boulder surfaces in the basal conglomerate in situ. These features suggest that B. bisulcatus inhabited in bay environments at the early transgressive stage. On the other hand, C. sendaicus was distributed over open-coast environments during subsequent marine flooding. The in situ C. sendaicus provides strong evidence for the reconstruction of the extinct species habitat.


ABSTRACT The purpose of this study is to examine the impact of cashback usage restriction exemption (CURE) on travelers' intention to prefer a brand's mobile application (m-app). Using a mixed-method approach, we have established that the CURE enhances the intention to use a brand's m-app. It was observed that the subjective norms, perceived behavioural control, anticipated positive emotions, and frequency of past behaviour affected the travelers' desire to use a particular brand's m-app for travel bookings if CURE is provided. Moreover, if CURE is added as an additional construct to the model, then the extended Model of Goal-Directed Behaviour (MGB) predicts the intention better than the extended Theory of Planned Behaviour (TPB).


The United States is the earliest country to develop entrepreneurship educational in the whole world,and its entrepreneurship's educating has already formed a very perfect system.This text,through the analysis to entrepreneurship education in American universities,introduced the main mode and characteristics of its entrepreneurship education and provided certain angle of view and way of thinking for entrepreneurship education of our country universities.


Untended gates - the triumph of vulgarity in an age of show business paperbacked culture - how candles became shoes peepshow America - Hollywood and popular taste programming television - reflections on the electronic midway vulgarity victorious - the collapse of cultural hierarchy in postmodern America.


: Let { Z n } n ≥ 0 be a critical or subcritical d -dimensional branching random walk started from a Poisson random measure whose intensity measure is the Lebesugue measure on R d . Denote by R n := sup { u > 0 : Z n ( { x ∈ R d : | x | < u } ) = 0 } the radius of the largest empty ball centered at the origin of Z n . In this work, we prove that after suitable renormalization, R n converges in law to some non-degenerate distribution as n → ∞ . Furthermore, our work shows that the renormalization scales depend on the offspring law and the dimension of the branching random walk, which completes the results of [12] for the critical binary branching Wiener process.


World has changed. Everybody is connected. Almost each and everyone have a mobile phone. Millions of SMSs are going around the world over mobile networks in every second. But about 113 of them are spam. SMS spam has become a crucial problem with the increase of mobile penetration around the world. SMS spam filtering is a relatively new task which inherits many issues and solutions from email spam filtering. However it poses its own specific challenges. Server based approaches and Mobile application based approaches are accommodate content based and content less mechanism to do the SMS spam filtering. Though there are approaches, still there is a lack of a hybrid solution which can do general filtering at server level while user specific filtering can be done on mobile level. This paper presents a hybrid solution for SMS spam filtering where both feature phone users as well as smart phone users get benefited. Feature phone users can experience the general filter while smart phone users can configure and filter SMSs based on their own preferences rather than sticking in to a general filter. Server level solution consists of a neural network along with a Bayesian filter and device level filter consists of a Bayesian filter. We have evaluated the accuracy of neural network using spam huge dataset along with some randomly used personal SMSs.


Although silacyclobutanes appear susceptible to penta- and hexacoordination of their Si atoms because of their inherent so-called ring-strain-release Lewis acidity, we succeeded in synthesizing a pentacoordinate (trigonal-bipyramidal) silacyclobutane with equatorial Si−C bonds. A related silacyclobutane with an axial−equatorial Si−C situation was found by quantum-chemical calculations to have a low energy barrier (ca. 3 kcal/mol) for its transformation into an isomer with exclusively equatorial Si−C bonds.


Learning process at SMK Ma'arif 2 Sleman still passive and uncontrolled, this condition affects to the student learning outcomes. The role of the teacher in the learning process needs to be improved with the right methods to make students more active and encourage the student to solve the problems. Problem-Based Learning (PBL) is one of learning method which the characteristics capable of demanding learners actively and directly involved in the learning. The Aim of this study is want to know affect  PBL method can increase the activity and psychomotor learning outcomes of students. The subjects were students of class XI SMK Ma'arif  2014/2015 academic year. Collecting data used in this research is qualitative descriptive analysis. The results showed an increase in activity of learners by 12.98% and psychomotor learning outcomes by implementing PBL increased 9.01%. The conclusion using PBL method was known that activities of students increase practical subject.


This chapter examines the scope, conditions, and applicability of the theory of rebel retirement through informal exit networks beyond India. It considers the scholarly implications of this book on areas of conflict and peace studies, as well as for democratic consolidation in developing countries. It also examines how the North-South variation in India can suggest some actionable policy instruments to bring militant disengagement, particularly in cases where a ceasefire between the state and rebels has not produced complete demobilization of rebel groups. Policymakers concerned with weaning rebels away from extremism might therefore find these conclusions useful.


Beginning with the problems existing in the present food security,the author points that market machinery and government machinery has possible failures in the governance of food safety.Food safety governance is a corporate progress that government、market and society govern food quality under some "institution arrangement",and guarantee customers can buy safety foods.Therefore,the article introduces food security problem to public government analysis model,proposing that government,food production enterprises,third department and so on should have the interactive coordination to realize food security and construction of the new food security policy system.


Three-dimensional parametric modeling of excavators boom was completed in this paper by using of Pro/Engineer,and finite element analysis(FIA) is made by using of Pro/Mechanica module,finally through the simulational analysis results,we provide a basis for the optimization of products.


Alumina supported N-bromosuccinimide was found to be an efficient reagent for ring bromination of a number of aromatic compounds under solvent-free conditions. In the absence of the alumina the reactions are slow and some of the substrates are recovered unchanged. Under the reaction conditions aromatic oximes are converted into the corresponding carbonyl compounds. The method is simple, safe and rapid.


The objective of this study was to evaluate the efficiency of ozonated water as an antimicrobial agent in the Nile tilapia (O. niloticus) processing. Samples of whole tilapia and fillets were washed with cold water (11 ° C), without ozone (0 ppm control) and with ozone (0.5; 1.0; 1.5 ppm) for 0; 5; 10; and 15 minutes. Microbiological parameters (total count of mesophilic, Staphylococcus aureus positive coagulase counts, fecal coliforms and the presence of Salmonella sp.) and physicochemical parameters (pH, color, TBA) were evaluated in order to check the microbiological load reduction and possible changes on pH, color and lipid oxidation (TBA) of fillets. The most effective ozone concentration on reducing the microbial load of the surface of tilapia was 1.5 ppm, reducing the initial populations of mesophilic bacteria in 91.78%. At this concentration (1.5 ppm), it was effective within the first 5 min., reducing the microbial load of 71.23%. In fillet washing, 1.5 ppm ozone concentration also showed the greatest reduction of mesophilic bacteria 70.19%. The treatment with ozonated water of fillets showed no influence on the pH and color of the fillets, however, there was an increase in the TBA value (1.5 ppm of O3 for 15 min.), showing that lipid oxidation occurred, but below the thresholds that make them unfit for consumption. The results showed that the ozonated water has been effective in reducing the microbial load of the fish during processing. The cost of electricity consumption used for ozone generation demonstrated its feasibility of use.


Fuzzy sei theory (Zadeh 1965, 1978; Zimmermann 1985) gives an adequate workframe to model such kind of imprecision and has been applied with success to severa! domains and systems. In this paper, it wil1 be used to obtain approximate possibi1ity distributions of line or pipe flows evaluated from a fuzzy description of node consumptions. In lhe Appendix one may fmd some brief notes on basic concepts of fuzzy set theory. Steady state fuzzy flow modelling in networks is proposed. in an unified approach. to take in account qualitative aspects or vagueness and uncertainty in data that have not probabilistic or random nature. An incremental approach is adopted. starting from a previously calculated feasible operating point. Based on concepts from fuzzy set lheory. approxirnate possibility distributions for branch flows and nade potentials are then evaluated. The formulation derived is identified with gaz and electric nctworks and may forro the basis for network planning-aid-syslems developmcnt. Electrical and gaz networks have in common a ser of features such as topology description and Kirchhoff laws. 80th systems are usually described in such a way that lhe mathematical models are non linear. In arder to deal with fuzzy quantities. they must be linearized so that flows can be directly related to nade injections. Linearizauon of electrical system models has led to lhe well known DC modelo Linearization of gaz systems implies lhe linearization of pipe flow equations. ~ TNTRODUCTTON Computer simulations of steady state power nows in electrical systems or gaz nows in gaz nctworks aim at estimating the values of node voltages or pressurcs and branch nows for known consumptions at load nodes ando eventually, known source node volt:lgcs or pressures. In this paper. an unified approach is for lhe first time presented for both systems, based on lhe calculation oi a sensitivity coefficient matrix relating branch flows to fuzzy power injections. The idea behind them. however. may be generalized to other distribution systems. The presentation of algorithms in the li ter atUre to solve this problem has always dealt with it from a detcrministic point of view. However. it is recognized that data may have other nature. namely probabilistic. This would be the case if. for instance. a consumption would be known through a probabilistic distribution. DESCRIRING FUZZY LOADS Loads will be described by fuzzy numbers. which come associated to a possibility distribution having the properties of a membership function. In other cases. data has a nature that is neither deterrninistic non probabilistic. In planning. for instance. lhe analysis of consumption trends depends on lhe evolution of economic activities and competition among severa! sources of energy which affect forecasts. There are. thus. scenarios to be considered and this makes it unrealistic to choose. in a deterministic sense. specific values for problem data. A simple way of specifying a load is through a triangular or trapezoidal fuzzy number, such as in fig.l., as suggested in (Freska 1982). '-" Besides, the uncertainty found in planning judgements is greatly due incomplete human knowledge that cannot be represented by a probabilistic approach, because looking into the future is really not the same as considering a workframe of repetition of events. Nevertheless, judgemems are produced based on human accumulated knowledge and experience and translated imo linguistic declarations such as "Consumption in nade 10 will be approximately 1 m3fs" or "Load in nade 5 has a domestic type diagram". Such declarations clearly have a vague nature of a third kind, possibilistic. It is therefore important to use concepts and adopt techniques to capture the fuzzy nature that often characterizes human activity or human knowledge. Fig.l Trapezoidal fuzzy number modelling a fuzzy load The planning engineer must dcclare and interval [L2.L3J where loads are considered typical possible valucs for thc type of consumption and time stcp; and valucs LI and 1..4. under and above which lhe 10ad is estimated not possible to occur. Then. values in lhe intervals [LI. L2] and [L3. L4] are taken as possible representations or lhe load but not with lhe same strength as values in [L2. L3]. These conditions are translated by lhe values or lhe membership function depicted in fig.I. formulation that will then be used to provide lhe fuzzy equations needed. Therefore. a deviation 6L in loads from lheir specified value will lead to f = f o + 6f ; P = P o + 6P ; Ls = L so + 6Ls I,inpur hr:lnch flo\ys Linearization of branch flows is a needed step in arder to deal with fuzzy quantities. In general. a linear branch flow equation in line i-j is described by This representatian can be laakcd at as a translalian af a sentence ar a linguistic declaratian af Lhe kind "Joad mar occur between LI and L4 but It Is Jlkely to be between L2 and LJ". fij = Kij-l(Pi-Pj) (1)


An ANSYS model is adopted to calculate the maximum stretch stress of concrete pavement with void under slab considering the effect of slab thickness,void depth and area under slab,the result is used to analyse the fatigue life of concrete pavement with void under slab.


The paper systematically reviews the theoretical and empirical researches in China and foreign countries on "the influence of China's rural labor transfer on urban-rural income gap" in recent years.Emphases are put on explaining different theoretical views about "why urban-rural income gap is not narrowed by large scale rural labor transfer",and the empirical test to prove the hypothesis that "China's rural labor transfer has narrowed urban-rural income gap".Based on the critical analysis of different theoretical views and empirical test methods,suggestions on how to deepen and expand the research are proposed.


A database comprising about 1, 500 drugs clinically used in Japan has been constructed aiming to mine the information regarding essential chemical characteristics suitable for drugs. The ring systems and functional groups observed in drugs have been extracted and compiled into a part of the database. Although the relevant information is relatively biased, it would assist drug designers in the selection of chemical scaffolds and functional groups.


Well, how are we starting out this year? In my opinion, good and positive. We have over 16,000 students here—a recent record. We are making progress on improving our students' retention, persistence, and graduation rates. Retention is now at 87%--a jump of 2 points in one year; persistence is solid with new programs that are helping students continue toward graduation – such as our TRIO program, Achieving College Excellence, which retained 100% of students-about 160 at-risk or first generation students are back for a second year; and our graduation rates have improved– our official rate has climbed from 65 to 70% in two years.


Models of human behavior and cognition (HB C) are necessary for understanding the total response of complex systems. Many such model have come available over the past thirty years for various applications. Many potential model users remain skeptical about their practically, acceptability, and usefulness. Such hesitancy stems in part from disbelief in the ability to model complex cognitive processes, and a belief that relevant human behavior can be adequately accounted for through the use of common-sense heuristics. This paper will highlight several models of HB C and identify existing and potential applications in attempt to dispel such notions. 26 refs.


An accurate kinetics treatment is applied to the muonic helium atoms formed by a muon's sticking to the charged particle produced in muon-catalyzed d-d and d-t fusion. Cross sections for l- and n- changing transitions are included to describe density-dependent stripping and x-ray production. Coupled with recent accurate calculations of the initial sticking, the results are generally in very good agreement with experiments. The noteworthy exception is that the density dependence of the sticking is much weaker than previously observed, in agreement with preliminary results of a new experiment.


Elizabeth Gaskell's Mary Barton has attracted many critics' attention because of its industrial theme, but they claim that the novel has disappointed them with the unrealistic and bourgeois resolution of the class conflict. Some extreme Feminist criticisms try to stress on John Barton's oppression and Mary's anger at her father, which is not to the point of the theme and structure of the novel. The limited interpretations of the viewpoints cannot appreciate the full meaning of the novel, but gender criticism can open a new meaning of the novel with the pattern of inversion and reversion of gender roles. The pattern of inversion and reversion of gender roles is related not only to female and male characters in the novel but also to the writer and her narration. Gaskell herself upsets her gender role by writing the novel and speaking out her opinion about class struggle. But she tries to return to the proper place in her gender role by the humble confession of her ignorance. Mary in the novel also overthrows her gender role when she goes alone to Liverpool trying to find a witness to save Jem and exposes herself and her love in front of the public in Jem's trial. But she recedes into feminine shame and helplessness again. This duality of the movements in the novel is that of feminine desire as shown in the mermaid story narrated by Will. The male characters also follow the pattern. Not only John Barton and Mr. Wilson but also Job Legh show the deep "mothering" instinct in the first half of the novel. They invert their male gender role and follow the female ethic of saving and nurturing life. John Barton in the second half of the novel turns into a murderer, which is the symbolic act of avenging morality of the male public sphere. So he completed the pattern of inversion and reversion of the gender role. On the other hand, Mr. Carson whose son is killed by John Barton desires to kill the killer and take his revenge on the murderer. But in the conclusion of the novel he inverts his gender role and like Madonna in Michelangelo's Pieta, he embraces Barton and forgives him. Inverting gender roles in the novel represents the desire of saving and nurturing life and eventually the novel implies that it is the crucial key to solving the contemporary social problems.


Advancing equity in early childhood education is crucial as our broader society faces issues of inequities across systems, including education. Professionals must honor children's home language and cultural contexts, coming from a perspective of value and respect rather than from a traditionally dominant Eurocentric perspective. Through this study, we share the perspectives of 22 U.S. parents of dual-language learners (DLLs) as they experienced an evaluation for preschool special education. Through a mixed-methods approach using survey and interview data, three primary themes emerged: (a) relationships and interactions, (b) home language and cultural context, and (c) the evaluation process. Significant differences in satisfaction emerged between those who had participated in Part C Early Intervention services versus those who had not.


Genome‐wide association studies identified protein tyrosine phosphatase non‐receptor type‐2 (PTPN2) as a susceptibility gene for inflammatory bowel disease (IBD), Diabetes and Celiac disease, while loss of the PTPN2 protein product T‐cell protein tyrosine phosphatase (TCPTP) compromises intestinal epithelial barrier function. The protein composition of tight junctions (TJ) determines the tightness of the barrier and alterations in select TJ proteins leads to increased paracellular permeability. Tricellulin (also called marvelD2) is a recently discovered tight junction (TJ) protein, which is preferentially localized at tricellular contacts. Tricellulin plays an important role in the maintenance of intestinal epithelial barrier function by restricting paracellular permeability to macromolecules. The aim of the present study was to identify the molecular mechanism underlying barrier defects in TCPTP‐deficient intestinal epithelial cells (IEC). For this purpose, we developed Caco2‐BBe and HT‐29 intestinal epithelial cell lines (IECs) expressing short hairpin RNA for TCPTP using a lentiviral system to stably knock down TCPTP expression (TCPTP‐KD). Western blot analysis indicated that TCPTP expression was significantly reduced (by 45 ± 4%, p<0.01, n=3) in TCPTP‐KD cells. FD4 permeability was increased in KD cells (p<0.001; n=3) compared to control cells. Western blot and immunofluorescence studies revealed that the expression of tricellulin expression was decreased (WB: 44 ± 8.8%, p<0.05; n=3) in unchallenged TCPTP‐KD cells compared to control shRNA transfected cells. This decrease was further enhanced by challenge with the pro‐inflammatory cytokine interferon‐gamma (IFN‐g) (n=2). In previous studies, we observed increased basal phosphorylation of the TCPTP substrate ERK1/2 in TCPTP‐KD cells. Moreover, an inverse relationship exists between mitogen‐activated protein kinase kinase kinase 1 (MEKK1) that lies upstream of ERK1/2, and MarvelD3, a member of the same protein family as tricellulin. To investigate whether tricellulin loss in TCPTP‐KD cells occurs through MEK/ERK signaling, TCPTP‐KD IEC were treated with the ERK1/2 inhibitor U0126 (10mM) for 14 hours. ERK inhibition rescued tricellulin expression in TCPTP‐KD cells. In conclusion, we report that tricellulin expression is down regulated, at least in part, by the MEK/ERK pathway and that decreased tricellulin levels could contribute to the increased macromolecule permeability in cells lacking TCPTP.


Legionella pneumophila is a rarely diagnosed microorganism in Serbia. It causes legionellosis, usually a mild respiratory infection. However, in some cases it can be severe and even life threatening. In June 2020, during the COVID-19 pandemic, a patient with symptoms of the aforesaid infection, namely severe pneumonia and acute respiratory distress syndrome, was admitted to the hospital. The multiplex polymerase chain reaction (PCR) test (The BioFire FilmArray Pneumonia Panel plus) detected the presence of L. pneumophila in the patient's bronchial secretions. The specific culture for the detection of that organism, however, remained sterile. The patient's paired sera had been sent for serology and the results in both of them came back positive for Legionella spp. 1–6, while the assays specific for each one of the 10 serogroups detected more than a fourfold increase of antibody titers in an uncommon serogroup 2 only. The patient was treated with moxifloxacin; he recovered well and was discharged after 26 days of hospitalization. Having being diagnosed with the L. pneumophila infection correctly through the multiplex PCR test, the patient was given the right therapy with moxifloxacin. The serologic assays corroborated this result and revealed the uncommon group 2, thus confirming the necessity of carrying out all the tests available to attain the exact diagnosis of legionellosis.


Objective To analyze the overweight and fatness conditions of the pupils aged seven to ten at surveillance schools in Longgang district of Shenzhen city.Methods From April to May in 2005,4?758 pupils from one to four grades were exmained in three surveillance schools in Longgang District.According to body mass index(BMI) separate criteria on screening of fatness and overweight of Chinese school age children and adolescent recommended by Chinese work group of International Life Science Institute(ILST) on fatness problem,adopting χ~2 analysis technique,240 pupils were selected respectively into fatness group and normal body weight control group from pupils which volunteered to take part in topic research by analyzing 3?836 objects from seven to ten years old.Results(1)The total fatness rate and the overweight rate was 7.22%,10.53% respectively in 3?836 pupils;both the fatness rate of group at the age of seven years and the overweight rate of group at the age of ten years were the highest;(2)The fatness and overweight rate between boys and girls showed significant differences.(3)There was no significant difference among four age groups.Conclusion Fatness and overweight of the pupils in Longgang District should not be neglected,parents and schools should emphasize on cultivating their custom of living,diet and motor behaviors.