: The issue under scrutiny is the possible nexus between the Curriculum Framework for Primary and Secondary Education for period 2015-2022 and Education 5.0, which currently seems to be in a state of taciturnity as the latter is purported to be germane only to Zimbabwe's Higher and Tertiary Education system. This article is, thus, informed by the 'functional curriculum theory' – a principle which accentuates the ideal of instructional relevance. Hence, this reflection is essentially secondary research whereby the writer reflects on earlier works to do with Education 5.0 as well as the Curriculum Framework 2015-2022 which is presently the principal document on infant, primary and secondary education in Zimbabwe. As emerged from this reflection, there is vivid compatibility between Education 5.0 which is the brainchild of the Ministry of Higher and Tertiary Education, Innovation, Science and Technological Development [MoHTEISTD] and the Curriculum Framework 2015-2022 as the invention of the Ministry of Primary and Secondary Education [MoPSE]. In conclusion, this reflection envisions the possibility of widening the scope of Education 5.0, which is achievable through transferring the Education 5.0 concept to Zimbabwe's secondary cycle of education. Therefore, if Education 5.0 begins to take root as from secondary school level then its success at higher and tertiary education level is further guaranteed. This article, therefore, recommends that Education 5.0 be extended to secondary school level with a view to brightening its chances of success in stimulating the modernisation, commercialisation and industrialisation agenda of Zimbabwe . for period 2015-2022 [herein Government of Zimbabwe


This study aims to explain the causes of the Civil War in Syria from an analysis of the demographic and geographical factors that characterize the Middle East and the artificial border boarders imposed by England and France through the secret agreement Sykes Picot 1916, and by its formalization in the Sevres Treaty of 1920. This was one of negotiated peace treaties of Paris in 1919. On the one hand, in Europe, the high population density in relation to the small territory increased the presence of wars between states in reason of subsistence. On the contrary, in the Middle East and Africa the extend territory, abundant natural resources and low population density allowed these countries to have peaceful relations between states. Therefore, there are not important sources of tax revenue. Indeed, income must be obtained by selling raw materials becoming rentier states which has generated less public participation in government. On the other hand, the creation of artificial borders by France and Britain divided the territories without taking into consideration important factors such as the diverse ethnic and religious composition of the Middle East. That has caused internal conflicts in most countries and has promoted the existence of various separatist groups. For instance Syria, there is a strong religious and historical rivalry between the Alawites (faction of Shiism), those in power and Sunni (governed). Finally, the result of the study is that Syria can be regarded as a failed state and divided in which the government cannot exercise the legitimate monopoly of force. It also shows how the different cultural aspects is important to the state cohesion. Moreover, the intervention of other abroad countries that have different realities affects negatively to others populations.


The self-diffusivity of {sup 54}Mn in single grain icosahedral Al{sub 70}Pd{sub 21.5}Mn{sub 8.5} quasicrystals has been determined by a precision grinding technique. In the range from 870 to 1093K the temperature dependence of the Mn self-diffusivity {ital D} follows the Arrhenius equation with an activation energy {ital Q}=(180.8{plus_minus}4.5) kJmol{sup {minus}1} and a preexponential factor {ital D}{sub 0}=3.4{times}10{sup {minus}4} m{sup 2}s{sup {minus}1}. The experimental results are discussed together with diffusion mechanisms proposed for quasicrystals from theoretical considerations. {copyright} {ital 1996 The American Physical Society.}


(...) Estimation of three weight grades of cones viz., light ( 6.1g) revealed seed from heavy cones to have high germinability, vigour index and maximum weight. A comparison of four density grades of seeds graded in a South Dakota seed blower with ungraded seeds indicated only those retained at the highest air-speed setting had higher germination and vigour. Collecting seed when the cones turn brown, and using dense seeds from large cones is recommented


The invention relates to a mixed-gas-protected automatic welding method of large-diameter steel member filament, comprising the steps as follows: (1) welding parameters of rich argon/carbon dioxide mixed-gas-protected automatic welder are set; and a large-diameter steel member is installed on welding turning rolls; (2) a bevel is prepared and two parent materials to be welded are aborally assembled; the aboral points are fixedly welded; and adjustment of the distance between the conductive nozzle and the work piece is determined; (3) material for positioning welding is selected, wherein, type of the selected material is the same as that of the welding material; a positioning welding seam is provided, wherein, the length of the positioning welding seam is generally not less than 50 millimetres; and the current of the positioning welding seam is controlled to be heavier than the current in normal welding; (4) the welding turning rolls are started up; the large-diameter steel member is rotated; and the rich argon/carbon dioxide mixed-gas-protected automatic welder is started up at the same time to carry out base welding; (5) filling and cover welding are then carried out and a welding torch is swung when necessary. The method can relieve labour intensity, has steady quality and high work efficiency.


The general multi‐configuration self‐consistent‐field (MC‐SCF) method is presented with no restrictions on the types of configurations participating in the expansion of the total wavefunction. The general coupled Fock‐like equations for the ``best'' orbitals to be used in such a multi‐configuration wavefunction are derived. Formally these coupled nonlinear equations are decoupled with the use of projection operators and transformed into a pseudoeigenvalue problem. Several general methods, based on orbital transformations and on the use of the generalized Brillouin theorem, are presented for solving the coupled nonlinear Fock like equations for the determination of the MC‐SCF orbitals. The formalism presented is applicable not only to the ground state of a given system, but also to any excited state, yielding an upper bound to the true energy of the desired state.


Identifying insecticide resistance-related insect bacterial symbiont is a vital compass for promoting symbiont-based insecticide resistance management and insecticide-free insect pest control. Known insecticide-resistance-related symbionts lack universality and genetic manipulation, as either not widespread or unculturable. Here, we discovered a widespread symbiont Enterococcus casseliflavus of a significant invasive insect pest, Spodoptera frugiperda. This symbiont enhances host insecticide resistance to chlorantraniliprole by amide bond breaking and dehalogenation-related insecticide degradation, suggesting its great potential for Lepidoptera pest insecticide resistance management. Complying with the increase in exposure risk of chlorantraniliprole, the E. casseliflavus of insects' symbionts rather than mammals or environmental strains were notably enriched with putative chlorantraniliprole degradation genes. We also found that E. casseliflavus can transmit horizontally with high efficiency (100%) through cross-diet and cannibalism rather than vertical transmission from mother insect to offspring. Moreover, the widespread infection of E. casseliflavus in the field populations not only implies that an underlying symbiont-host co-evolution process driven by insecticide pressure might be underway, but also provides a novel therapeutic target of agricultural pests based on symbiont-targeted insect control (STIC).


The present invention provides methods to detect biomol ecules on a microarray using a Scanning electron micro Scope. In one embodiment of the invention, errors in oligo nucleotide Synthesis during manufacturing of microarrayS are detected by monitoring Synthesis of control probes on the chips. In another embodiment, misalignment of features on the chip is determined. In yet another embodiment, the size, shape and edge definition of features on the chip is determined. In further embodiments, methods are provided for analyzing interactions between an oligonucleotide target and an oligonucleotide probe on a microarray and methods for testing conditions in a microarray manufacturing pro


Lattice instantons: What they are and why they are important.- Gauge fields on the lattice.- Lattice gauge theories.- Some frontiers in constructive quantum field theory and equilibrium statistical mechanics.- New proofs of long range order.- Number of phases in one component ferromagnets.- A survey of local cohomology.- Operator algebras and statistical mechanics.- Foundations of equilibrium quantum statistical mechanics.- Unbounded derivations of C*-algebras and corresponding dynamics.- to the flow of weights on factors of type III.- The von Neumann algebra of a foliation.- Nuclearity and the C*-algebraic flip.- On the Connes spectrum of simple C*-dynamical systems.- Quantum field theory of massless particles and scattering theory.- Scattering theory in quantum mechanics and asymptotic completeness.- Static solitons in more than one dimension.- Geometry of Yang-Mills fields.- Periodic solitons and algebraic geometry.- Yang--Mills equations as inverse scattering problem.- Nonlinear evolution equations solvable by the inverse spectral transform.- Quantization of particle-like solutions in field theory.- Topics in infinite dimensional analysis.- Mathematical foundations of the renormalization group method in statistical physics.- On the renormilization group for the hierarchical model.- Fluctuationes in Curie-Weiss exemplis.- On the problem of the mathematical foundation of the Gibbs postulate ie classical statistical mechanics.- Dynamical systems with turbulent behavior.- Generic properties of Navier-Stokes equations.- A limit theorem for turbulent diffusion.- Many particle scattering aitlitudes.- A Remark on equations of motion in asymptotically free theories.- Short-distance expansion for products of current-like operators.- The use of exterior forms in field theory.- On extensions of flows in the presence of sets of singularities.- On the uniqueness of the equilibrium state for plane rotators.- A geometric approach to the solution of conformal invariant field equations.- Stability, detailed balance and KMS condition for quantum systems.- Stochasticity and irreversibility in infinite mechanical systems.- Why the KMS states?.- A comment to the talk by E. Seiler.


WHENEVER THERE IS UNCERTAINTY about product quality a consumer may benefit from obtaining information about the performance of commodities; indeed the choice of what information to purchase becomes an essential part of the consumption decision. Consumers acquire information from a variety of sources. For some commodities it is possible to test small amounts of a product before making a large purchase; taking a test drive in a car is an example. In other cases information is gathered informally from acquaintances. In yet other instances, information is supplied by newspapers, magazines and consumer information organizations. Regardless of the method used to collect information, the acquisition process is usually costly, sometimes in terms of time and often in terms of money. When the consumer makes the decision to purchase information he weighs these costs against the benefits of being informed. The purpose of this paper is to develop a theory which explains consumer expenditures for product quality information. The theory is related to the neoclassical consumer theory but differs from it in several critical respects. There are important reasons why the standard consumer theory is inappropriate for the study of information demand. The primary reason is that information is fundamentally different from other commodities, and the difference is crucial. Consumers demand most other commodities for the desirable attributes they possess, whereas information possesses none of these attributeS. A consumer purchases information because it helps him to make "better" purchases. The demand for information is therefore a derived demand that only arises when product quality is uncertain. These special features of information may give rise to demand behavior quite different from that usually observed for commodities. Since the neoclassical theory cannot be interpreted to incorporate the special features of information it is unable to explain the unique properties of information demand. The theory presented in this paper should also be constrasted to Stigler's early contribution [10] to the economic theory of information. Stigler investigated consumer demand for information about prices of products. He did not treat the demand for information about product quality. Nor is it possible to simply extend his analysis to explain consumer demand for product quality information. The demands for the two types of information arise for different reasons


Robert Hendrickson. The Facts on File Encyclopedia of Word and Phrase Origins - Revised and Expanded Edition. New York: Checker Books, 2000. William Safire called the first edition of Word and Phrase Origins, "A feast for phrase detectives ... that will enliven debates and illuminate issues." This revised and expanded edition, which contains more than 9,000 entries - 2,000 entirely new, enlarges the feast with more details and an index that can enable readers to more quickly locate interesting people, categories, and anecdotes. In his preface to the original edition, Robert Hendrickson, the book's author, noted that etymology is not an exact science and that word derivations are often little more than educated guesswork. Nevertheless, echoing the late, great word detective Eric Partridge, Hendrickson believes "even a guess is better than nothing - even if it's just inspired fun, or if it merely stimulates thinking that leads eventually to the expression's true origin." The following sample entries are selected from the beginning, middle, and end of the book. 1. Aha! - William Safire (in his New York Times Magazine column "On Language," 2/17/97) calls this exultant cry of discovery "one of the great, unappreciated and deliciously nuanced words of the English language." First recorded in Chaucer The Canterbury Tales (c. 1387). 2. a chicken in every pot - often attributed to Herbert Hoover, this synonym for prosperity was a Republican campaign slogan during his election of 1932 - a ridiculous one that helped the Democrats more than the Republicans, with the Great Depression gripping the land. But the words actually can be traced to Henry IV of France and his vow on being crowned king in 1589, "If God grants me the usual length of life, I hope to make France so prosperous that every peasant will have a chicken in his pot on Sunday." 3. sandwich - At 5 a.m. on April 6, 1742 John Montagu, fourth earl of Sandwich, was playing cards and feeling hungry. The earl, an inveterate gambler, did not want to leave his card game for a meal and so he asked his man to bring him some cold, thick-sliced roast beef between two pieces of toasted bread. Thus the sandwich was born. 4. yuppie - a slang term that has been around for over a decade. It was first recorded in 1983 by syndicated columnist Bob Greene, who overheard it in a bar. As Greene explained the word's origin: "While [Gerry Rubin] and Abby Hoffman once led the Yippies - the Youth International Party - one social commentator has ventured that Rubin is now attempting to become the leader of the Yuppies - Young Urban Professionals. " Hendrickson, the author of more than 25 books on language, literature, and other topics, is already at work on the 3rd edition of Word and Phrase Origins but that is no reason to delay picking up a copy of the current version which contains plenty of fascinating and fun derivations that can be used to liven up run-of-themill cocktail party chatter and enlighten inquiring minds. …


(54) PEPTIDES FOR THE TREATMENT OF (51) Int. Cl. HERPES VIRUS INFECTIONS A638/17 (2006.01) (52) U.S. Cl. ..................................... S14/12 (75) Inventors: Wolf-Georg Forssmann, Hannoyer (58) Field of Classification Search ................... 514/12, (DE); Frank Kirchhoff, Ulm (DE), Jan 514/14: 530/324, 327, 333,344, 345, 402 Minch, Ulm (DE); Ludger Ständker, See application file for complete search history. Hannover (DE) (56) References Cited 73) Assi : IPF Ph Ceuticals GmbH (73) Assignee tertains utical mon U.S. PATENT DOCUMENTS


Thrombocytopenia may be a reduction in circulating platelet counts. Primary thrombocytopenia or idiopathic thrombocytopenia purpura (lTP) is an autoimmune disorder of unknown condition and thrombocytopenia that a result of a known condition called secondary thrombocytopenia. FCGR llb is sort of Fc gamma receptors FcgRs are receptors for (IgG), FcyRIIb is that the only inhibitory FcyR who particularly expressed about B-cells. FcgR llb move vital roles in pathophysiology regarding the many autoimmune disorder like thrombocytopenia. The study was applied on 85 people aged 20 to 69 year; 65 patients' group with thrombocytopenia and 30 healthy group as a control group in Holy-Najaf. The group of patients was divided into subgroups based on gender, age, body mass index (BMl), primary and secondary thrombocytopenia. The complete blood count was examined for all patients group and healthy group. FCGR llb serum level was significantly decrease (P 0.05) in serum FCGR level in female patients group compared with male patients' group. Also the results indicated non-significant differences (P>0.05) in serum FCGR llb level of patients at different ages group and different types of body mass index (normal weight, over weight and obese weight) respectively The results of correlation and linear regression indicated significant positive correlation (P 0.05) correlation between FCGR llb and leucocyte counts in primary thrombocytopenia while non-significant positive correlation between FCGR llb and platelets concentrations and a significant positive correlation (P<0.05) between FCGR llb and leucocytes counts of secondary thrombocytopenia. The serum FCGR llb level was considerably related with platelets counts in lTP so a useful indicator for lTP.


Monoclonal antibodies (mAbs) as therapeutics for cancer have shown some success in the clinic. These biologics are useful if targeting a cancer specific epitope. Cancer patients can generate tumor-specific B lymphocytes which can be isolated to develop human mAbs against tumor-associated antigens. The best source of anti-tumor antibodies is from sentinel lymph nodes. Pritumumab (also referred to as CLNH-11, CLN-IgG, or ACA-11) is a classic example of a natural human anti-cancer antibody. It is a natural human IgG1 kappa antibody developed by the human hybridoma technology, using B lymphocytes isolated from a regional draining lymph node of a patient with cervical carcinoma. In the original patient from whom the B lymphocyte was isolated, the bioavailability of the target antigen induced a natural immune response resulting in the generation of the pritumumab IgG. The target antigen recognized by pritumumab is cell surface expressed vimentin, also referred to as ecto-domain vimentin (EDV). Vimentin is an intracellular cytoskeletal protein overexpressed during epithelial-to-mesenchymal transition (EMT), a process integral to cancer cell metastasis. Pancreatic cancer is a deadly disease with poor prognosis. No more than 6% of pancreatic cancer patients will survive beyond five years after diagnosis. There is a clear unmet need to help improve outcomes for patients. (A) Purpose of the study: to examine if pritumumab mAb can target pancreatic cancer cells and inhibit pancreatic tumor growth. (B) Experimental Procedures: Immunohistochemical analysis with horseradish peroxidase (HRP)-conjugated pritumumab on pancreatic cancer patient tissue sections along with immunofluorescence, flow cytometry, and In-Cell ELISA to demonstrate antibody binding. Antibody-dependent cell-mediated cytoxicity (ADCC) was performed to determine mechanism of action. In vivo subcutaneous xenograft mouse model treated with pritumumab to assess efficacy of the antibody for tumor inhibition. (C) Results: In this study we demonstrate pritumumab binds to the cell surface of patient pancreatic cancer tissue and binds the surface of established pancreatic cancer cells in culture. We show antibody binding to these cells induces antibody-dependent cell-mediated cytoxicity (ADCC). Furthermore, pritumumab effectively inhibits pancreatic tumor growth in a xenograft mouse model. (D) Statement of Conclusions: overall, these data provide pre-clinical validation of pritumumab mAb as a therapeutic for pancreatic cancer. Citation Format: Ivan Babic, Natsuko Nomura, Eric Glassy, Elmar Nurmemmedov, Venkata Yenugonda, Mark Glassy, Santosh Kesari. Pritumumab mAb binds cell surface expressed vimentin on pancreatic cancer cells and inhibits tumor growth [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 3828.


Geometric morphometric methods were used to investigate shape variation in the neuropodial chaetae (uncini) of the polychaete genus Polycirrus (Terebellidae: Polycirrinae). Illustrations of 82 uncini from 47 specimens/taxa (one to three uncini per specimen/taxon) were digitized and 10 landmarks, representing putatively homologous points, were identified on the outline of each uncinus. Two distinct types of uncini were identified and described graphically using a Principal Component technique (Relative Warps Analysis) and non‐metric ordination (multi‐dimensional scaling). Type 1 uncini with a short occipitium and flat base and Type 2 with a long occipitium and arched base represent states of a new character available for future phylogenetic studies of the group. The shape of the uncini alone subdivided the genus into two groups, one containing 14 taxa and another with 33 taxa. The type of uncini correlated well with the presence of long pinnate notochaetae and the last occurrence of notopodia, enabling further subdivision of the genus into four provisional groups; a key is provided to distinguish the groups. The landmarks identified on the surface of Polycirrus uncini are considered homologous with those on the uncini of other Terebellidae and therefore landmark‐based geometric morphometrics could be applied to investigate shape changes in other uncini‐bearing Terebellidae.


Early Education Curriculum of the view that all children are loved bio-psychosocial and cultural, unique and unrepeatable and ranks as central players the teaching-learning process. Consequently, they are subject learning from their needs, potentials and interests, therefore, the document It recognizes and gives value to the desires, feelings, rights and expectations of children, considering and responding to their specific characteristics (level of development, age, personality characteristics, rhythms, styles of learning, cultural context and language)


On the base of our previous studies due to the presence of halides in our complexes there is strong probability for obtaining coordination polymers. Crystal engineering well-defined as the understanding of intermolecular interactions in the context of crystal packing and the utilization of such understanding in the design of new solids with desired physical and chemical properties. Owing to the fact that the small changes in the ligands may play a significant role in the complexes, the organic ligand (1-naphtyl pyridine-2-carboxylate) (L), was synthesized. In order make more steric repulsion around of the complexes resulted in the substitution effect around of the naphtyl moiety was hired in the design. Relocation in the position of functional group was fulfilled our expectations. Three new mercury (II) halide complexes, [Hg(L)2Cl2] (1), [Hg(L)2Br2] (2) and [Hg(L)2I2] (3) were synthesized. All of the compounds were fully characterized using FT-IR, TGA, DSC, mass spectrometry, CHNOS elemental analyses, PXRD, NMR and SCXRD. The results indicate that metal-ligand polymerization controlled by substitution effect. The coordination geometry around the Hg (II) ion is seesaw shape in distorted tetrahedral geometry for compounds (1), (2) and (3) with τ4 of 0.74, 0.76 and 0.78, respectively. Due to the replacement of the functional group (mentioned substitution effect), flexibility of coodinated ligand was decreased. In the previously reported structures, the angle between two planes of aromatic rings in the analogous ligand was 78.37o which changed to the 59.47o, 50.75o and 64.90o for mercury halide series complexes. In present study these angles are 89.09, 89.73 and 88.90 for titled complexes based on new designed ligand. Consequently, this study emphasize that the substitution effect can play the significant role through the flexibility of designed ligand to control the metal-ligand polymerization.


[Objective] The aim was to study the start-up process of multistage anoxic-anaerobic-aerobic sequencing batch rector(SBR) for removing nitrogen and phosphorus.[Method] Biological removal of nitrogen and phosphorus species from a synthetic wastewater was investigated in a SBR operated under a variable aeration strategy to achieve the most desirable anoxic-anaerobic-aerobic stages in each cycle.[Result] Operating parameters of the SBR process was as follows: 75 min anoxic → 35 min anaerobic(including entering water) → 120 min aerobic → 75 min anoxic → 35 min anaerobic(including entering water) → 120 min aerobic → 75 min anoxic → 35 min anaerobic(including entering water) → 120 min aerobic → 30 min static precipitation,and the elimination ratio of COD,TN and TP was 85.0%,80.0% and 85.0%,respectively.[Conclusion] The research provides theoretical basis for studies on the removal of nitrogen and phosphorus species from wastewater.


ABSTRACT Tihe stability of the structure underlying'ourteen item rating scalel (the In-Training Evaluation Report) when cbmpleted on two different groups of medical candidates was investigated at the Royal College of Physicians and Surgeons of Canada. In addition the relationship between the rating scale score and Scores on other. measures such as multiple choice and oral tests is reported. Results indicate that the factorial structures were similar for both groups of candidates and that the correlations between the scale and other measures were low. Implications for further research and improvement of the scale are also discussed. (Author/RC) IDENTIFIERS


Non-stationary inverse problems of deformed solid mechanics are among the most underexplored due to, inter alia, increasing dimension of non-stationary problems per unit as compared with stationary and static problems, as well as necessity to consider the initial conditions. In the context of the continuing progress of the aviation and aerospace industries, the question arises about technical condition monitoring of aircraft for the purposes of their safe operation. A large proportion of an aircraft structure consists of beam and rod elements exposed to various man-made and natural effects which cause defects inaccessible for visual inspection and required to be identified well in advance. It is well known that defects (such as cracks, cavities, rigid and elastic inclusions) are concentrators of stresses and largely cause processes, which lead to the destruction of elastic bodies. Therefore, the problem of identification of such defects and their parameters, i.e. the problem of identification, represents a great practical interest. Mathematically, the problem of identification represents a non-linear inverse problem. The development of methods of solving such problems is currently a live fundamental research issue.


Maxillary sinus septum is an anatomical variation in the maxillary sinus. Sinus septum is also an important anatomical structure that complicates sinus lift procedure. Aim of the Study : This study evaluated the prevalence of maxillary sinus septa in the edentulous and dentate maxilla using digital orthopantomogram. Materials and Method: This study was based on the analysis of digital orthopantomogram images for posterior maxilla that were obtained from patients who visited a Private Hospital. A retrospective analysis of 921 pairs of nonpathological maxillary sinuses was done. Patients who had pathological findings were excluded from the study. Results: Sinus septum was present in 217 (23.6%) of the 921 pair of maxillary sinuses. Totally, 704 (76.4%) patients did not have maxillary sinus septum. Also, out of 527 male patients, 125 patients had the septum and out of 394 female patients, 92 patients had sinus septum. Conclusion: This study gives an idea about the prevalence of sinus septum that would help a surgeon prevent a few possible complications during sinus lifting


Dielectric energy storage capacitors offer great potential in pulsed power devices due to the high power density and fast charging-discharging rate. Designing a host material with high field-induced polarization is of importance for developing dielectric energy storage materials via further composition modulation. In this paper, we compare the microstructure, dielectric, and ferroelectric properties as well as the energy storage performance of samples K1/2Bi1/2TiO3(KBT), 75KBT-25BiFeO3 (KBTF25), and 88KBT-12Bi0.85Nd0.15FeO3 (KBNTF12) in detail. It is found that, among three samples, sample KBNTF12 possesses the most complex local structure coexisting of a four-distortions with different polarities; meanwhile, sample KBNTF12 behaves as a strong relaxor, thus giving a high field-induced polarization. Besides, sample KBNTF12 realizes the highest electric breakdown strength Eb among three samples, which is resorted to the highest resistivity of grain boundary. Highest ΔP and Eb of sample KBNTF12 among three samples render it achieve ultrahigh stored energy density Ws of 6.94 J/cm3, high recoverable energy density Wr of 5.23 J/cm3, and high efficiency η of 75.4%. Our work suggests that 88KBT-12BNF binary composition be an optimal candidate for dielectric energy storage ceramics.


The process of hardware design space exploration requires both hardware parameters and mappings from the algorithm onto the target hardware to be discovered and optimized. Previous work has largely approached this simultaneous optimization problem by separately exploring the hardware design space and the mapspace—both individually large and highly nonconvex spaces—independently. The resulting combinatorial explosion has created significant difficulties for optimizers. We introduce DOSA, which consists of differentiable latency and energy models, as well as a gradient descent-based optimization technique to simultaneously explore both spaces and identify high-performing design points. Experimental results demonstrate that DOSA outperforms random search and Bayesian optimization by 2.80× and 12.59×, respectively, in improving DNN model energy-delay product, given a similar number of samples. In particular, we demonstrate DOSA's modularity and flexibility via transfer to a real DNN accelerator setting, where we achieve a 2.07× improvement in energy-delay product by augmenting our analytical model with a learned model.


Difficulties of the production process and complexities of the tracks relief, in particular, exert influence on the central nervous system of the locomotive crew members. In this connection, the article deals with the possibility of optimizing the control of the motoring component, electric locomotion drivers` professional activities by regulating their psycho-physical state.


Recently, disasters are often striking the earth. In case of those emergency cases, information sharing infrastructure is highly required to be available with minimum security. This paper proposes a basic concept of responsive event-driven safe and secure information sharing platform to respond the above requirement. Our idea is twofold. One is the robust ad hoc network concept. When hosts and terminals may lose accessibility to the existing infrastructure after the emergency, we propose to establish wireless ad hoc network environment with information-oriented routing and route multiplication for safety. The other is the data-driven platform to support the safe and secure information sharing, which achieves efficient real-time multi-processing capability without any runtime overhead based on the passive or data-driven execution mode. By virtue of the processor, we apply it to continuous packet filtering for security and multiple job handling.


Sweden is a country with vast coverage of mires and a long history of stduy on mire science.Distribution and cause of formation,study,use and conservation of mires in Sweden were analyzed by the author basing on field investigation,communication and reference synthesis.In the early phase of mire research,Swedish scientists were in the highest flight on mire classification,evolution and geobotany,and they had made a very important contribution to the development of mire science.At present,Sweden also keeps ahead in use and conservation of mires in the world.It paid equal attention to wise use and conservation of mires,so its management experiences are deserved for wetland management authorities in China to use for reference.


N Phospho ribosyltransferase (NMPRTase) is an enzyme catalyses the biosynthesis of NAD+. It is generally expressed more in cancerous cell lines. The inhibitors targeted to NMPRTase reduce the cellular NAD+ concentration which results in apoptosis and cell death, hence can be used to treat cancer. These inhibitors could also target the NAD+ dependent enzymes like sirtuins indirectly, which were implicated in many diseases like diabetes, neurodegeneration and inflammation. Thus designing inhibitors to NMPRTase would be a good strategy to treat various disorders. In the present work, crystal structure of NMPRTase (2GVJ) with 2.1 Ao resolution, was employed for the energy based pharmacophore model generation for the crystal ligand (FK866) and virtual screening was carried out using Glide docking (Schrodinger). Commercial databases were used for virtual screening.Top30 potential hits were shortlisted by comparing pharmaophore fitness, docking score and hydrogen bonds with crystal ligand. These top hits are the potential lead compounds for treating cancer and other disorders.


A solid-state electrochemiluminescence (ECL) sensor for the detection of reduced glutathione (GSH) based on a g-C_3N_4/ SiO_2 modified glass carbon electrode (GCE) has been developed in this research. The g-C_3N_4, which is employed as a luminophore, is simply prepared and exhibits an excellent ECL response. Mesoporous silica hollow spheres (SiO_2) with a large specific surface area are introduced here to increase the loading amount of g-C3N4. Compared to a g-C3N4 modified GCE, the g-C_3N_4/SiO_2 modified GCE displays a much higher ECL intensity. A high enhancement effect on the ECL intensity of g-C_3N_4/SiO2 modified GCE is obtained in the presence of GSH in the electrolyte. Moreover, the enhanced ECL intensity shows a good linear relationship to the GSH concentration in the range from 1.0 × 10^−7 to 5.0 × 10^−4 M, with a detection limit of 2.0 × 10^−8 M (6.1 ng/mL). Besides, the ECL sensor exhibits a good anti-interference ability and has been successfully applied in the detection of GSH in commercial samples. The proposed sensor provides a promising platform for life science.


Context. Colliding wind binaries are massive systems featuring strong, interacting stellar winds which may act as particle accelerators. Therefore, such binaries are good candidates for detection at high energies. However, only the massive binary η Carinae has been firmly associated with a γ-ray signal. A second system, γ2 Velorum, is positionally coincident with a γ-ray source, but we lack unambiguous identification.
Aims. Observing orbital modulation of the flux would establish an unambiguous identification of the binary γ2 Velorum as the γ-ray source detected by the Fermi Large Area Telescope (Fermi-LAT).
Methods. We used more than ten years of observations with Fermi-LAT. Events are phase-folded with the orbital period of the binary to search for variability. We studied systematic errors that might arise from the strong emission of the nearby Vela pulsar with a more conservative pulse-gated analysis.
Results. We find hints of orbital variability, indicating maximum flux from the binary during apastron passage.
Conclusions. Our analysis strengthens the possibility that γ-rays are produced in γ2 Velorum, most likely as a result of particle acceleration in the wind collision region. The observed orbital variability is consistent with predictions from recent magnetohydrodynamic simulations, but contrasts with the orbital variability from η Carinae, where the peak of the light curve is found at periastron.


Emotions undoubtedly surface, which teachers face while resulting from the session. It is consistent with Hargreaves' view that teaching, learning, and leadership have an irrevocably emotional nature, whether on purpose or accidentally. The study seeks to evaluate an English teacher's experiences. According to Webster and Mertova (2007), narrative inquiry is based on human tales, which give a framework for investigating how people experience the world through their stories. Webster and Mertova state that narrative inquiry is a subfield of narrative research. The inquiry aimed to examine the emotional geography of team teaching lecturers in the English Language Education Department. A 33-year-old male English lecturer at a private University in Majalengka enhanced his professionalism by participating in several international and national conferences, which reflected the aspects of social and emotional well-being, such as presenting his article and having some discussions with other scholars. During the team teaching, the participants were given the opportunity and trust to do every single activity from the beginning to the end. His teaching partner treated him very well in implementing various programs within the team teaching. In brief, the emotional geographies contribute to developing a lecturer's professional and cognitive aspects, which have been implemented during the instructional process. They also influence the way students learn and follow the lecturer's instructions and potentially shape them to have a good attitude when interacting with each other.


Total sulphur was determined in chips of six different metallic National Institute of Standards and Technology (NIST) Standard Reference Materials (SRMs) and in four different steel samples from foreign sources by isotope dilution thermal ionisation mass spectrometry (ID-TIMS). This procedure determines the concentration of sulphur with absolute accuracy using enriched 34S as an internal standard. The concentrations of sulphur (µg g–1) found in these SRMs were: SRM 1764, 118.8 ± 2.4; SRM 1765, 37.8 ± 1.1; SRM 1766, 23.5 ± 1.5; SRM 1767, 90.84 ± 0.96; SRM 132b (Tool steel), 30.27 ± 0.78; and SRM C2423 (Ductile iron), 6.4 ± 1.23. The uncertainties are 95% confidence intervals and include all known sources of random and systematic error. These standards are useful for calibrating analytical techniques that rely on external standards for the determination of sulphur in steels.


The article reveals the meaning of Decembrists' constitutional projects through the approach of new cultural and intellectual history. The author examines Decembrists' constitutional projects not only as the creations of state-legal thought that continued to form the foundations of constitutional law in the first quarter of the XIX century and political manifests, but also as the forms representing the historical consciousness of the Decembrists themselves.


Recent studies suggest that machine learning can be applied to develop good automatic evaluation metrics for machine translated sentences. This paper further analyzes aspects of learning that impact performance. We argue that previously proposed approaches of training a HumanLikeness classifier is not as well correlated with human judgments of translation quality, but that regression-based learning produces more reliable metrics. We demonstrate the feasibility of regression-based metrics through empirical analysis of learning curves and generalization studies and show that they can achieve higher correlations with human judgments than standard automatic metrics.


In this paper, a compact and broadband Wilkinson power divider at 1–6GHz is presented. The device has been designed and fabricated based on optimized prototype circuit of lumped Wilkinson power divider, using the Low Temperature Co-fired Ceramics (LTCC) technology. By taking advantages of the three-dimensional layout capability of the LTCC substrate, the embedded lumped circuit elements of the proposed power divider are arranged vertically for size reduction, which features a compact size of 6mm×4.4 mm×1.3 mm.


The relations between the output of cathode block and electrolytic aluminium and the technical development were summarized in this article.The measures for improving the quality of cathode block and technology advancement were described,and the problems existed were put forth.


Microbial fuel cell is one of the emerging technologies which utilize wastewater to generate electricity with the help of action of microorganisms. The real interest in microbial fuel cells has tremendously grown in recent years. It converts chemical reaction into electrical energy and helps in the recovery of energy from wastewater. The main objective of this study was to enhance the electricity production and simultaneously treat the wastewater. The lab scale model consists of double chamber microbial fuel cell, i.e., two separate chambers one with salt water and the other with wastewater representing anode and cathode, a salt bridge acting as proton exchange membrane; electrodes from batteries are used for this study. In this, the proton exchange and electron transfer occurs after the redox reaction. The microbes in the sludge or wastewater are responsible for the release of electrons. These electrons tend to move through the external circuit, producing electricity. For maintaining electrical neutrality salt bridge is used. The dual chamber microbial fuel cell used in this experiment produced an average voltage of 0.37mv for a wastewater volume of one liter. This set up is done on small scale, but with further and more detailed study it can be installed in industries that produce Microbial Waste water as a by-product to generate electricity and reuse the waste water for other processes after treatment.


Fetal rat adrenals have been grown in tissue culture. Some specialized properties of the adrenal cortical cells have been studied as an index of their degree of differentiation. Cells transformed morphologically by ACTH differ from controls in their ability to respond rapidly to a single dose of ACTH, as indicated by the yield of isocaproic acid from [26-14C]cholesterol. A correlation was also found between the structure and the steroidogenic activity of the cortical cell mitochondria. Chloramphenicol (0.3 μmole) was found to inhibit the ACTH-induced morphological differentiation of the mitochondria specifically. This inhibition was correlated with a block in the rise of steroid 11β-hydroxylation (mitochondrial) normally induced by ACTH. The rise in steroid 21-hydroxylation (cytoplasmic) was unaffected. The inhibitory effects of chloramphenicol were reversible if the cells were subsequently treated with ACTH alone after removal of chloramphenicol. The present results are consistent with the hypothesis tha...


This paper proposes two model reduction methods for large-scale bidirectional networks that fully utilize a network structure transformation implemented as positive tridiagonalization. First, we present a Krylov-based model reduction method that guarantees a specified error precision in terms of the H∞-norm. Positive tridiagonalization allows us to derive an approximation error bound for the input-to-state model reduction without computationally expensive operations such as matrix factorization. Second, we propose a novel model reduction method that preserves network topology among clusters, i.e., node sets. In this approach, we introduce the notion of cluster uncontrollability based on positive tridiagonalization, and then derive its theoretical relation to the approximation error. This error analysis enables us to construct clusters that can be aggregated with a small approximation error. The efficiency of both methods is verified through numerical examples, including a large-scale complex network.


D2 steel can be used to manufacture cold working molds with large cross sections, complex shapes, high impact forces and high wear resistance requirements. Cutting speed is an important process index of WEDM. In order to study the influence of WEDM process parameters on the cutting speed of D2 die steel and explore the process parameters at the maximum cutting speed, In this experiment, the electrical parameters pulse width, pulse interval and servo voltage were selected as test factors, and the cutting speed process indexes were analyzed and optimized by orthogonal test and response surface analysis method. Experimental results show that: the influence of main electrical parameters on cutting speed is consistent; the effects of pulse width, pulse interval and servo voltage on cutting speed decrease successively; the optimum process parameters obtained after optimization are consistent, pulse width 8μs, pulse interval 10μs, servo voltage 38V.


We review reports of microwave photonic links with gain >0 dB in the absence of electronic amplifiers, and their corresponding noise figures.


The aim of the present work was to port a standard-cell library for a Sea-of-Gates (a "SOG" is a pre-diffused circuit where just the "metal" layers are missing) from "CIF" files existing in a competitors format to Mentor Graphics library format. Obviously, neither "ICStation" nor "ICBlocks" have been designed to handle standard-cells on a "SOG". Therefore, many practical problems arose. In particular, we noted that "ICBlocks" when routing did not always respect the grid parameters we set, resulting in "DRC" errors of "poly-via" type between elements of the "SOG" and the routed intercon-nects.


This study aims to determine whether there is a relationship between smartphone use and the frequency of access to pornography and free sex behavior among adolescents at SMK Negeri 2 Samarinda. Methods This study uses quantitative research with a cross-sectional design. The results showed that students of class XI SMK Negeri 2 Kota Samarinda had Moderate Smartphone Usage Behavior totaling 205 respondents (93.2%). They then obtained pornographic access behavior as Moderate at 174 (79.1%). And low free-sex behavior is 168 (76.4%). The result is a significant value of 0.651 (p-value > 0.05), so there is no meaningful relationship between smartphone use and free sex behavior in SMK Negeri 2 Kota Samarinda students. These results obtained a significance value of 0.125 (p-value> 0.05), indicating a significant relationship between the frequency of access to pornography and free sex. In conclusion, adolescents' insights about the dangers and impacts of having free sex should be wiser in using smartphones and minimizing access to pornography to avoid free sex.

Keywords: Frequency of Access to Pornography, Smartphone Use, Free Sexual Behavior


To help reduce the risk of neural tube defects (NTD), current recommendations are that all women who could become pregnant should take a 400mg folic acid supplement per day prior to conception and continue to do so until the 12th week of pregnancy. While it is recognised that compliance with this guidance is sub-optimal, little is known about the reasons why. Women attending baby clinics and existing community groups in Fife, Scotland who had a healthy baby up to 20 weeks old were approached to provide information on their use of folic acid supplements before and during their latest pregnancy. A purposive sample to reflect a range of ages, parities, socio-economic and educational levels were invited to participate in focus group discussions to explore their beliefs, understanding and rationale surrounding supplement use. Two hundred and ninety two women were approached regarding participation and 211 (70%) provided information on their folic acid supplement use. Of these, 26 (12%) had not taken it at all, 67 (32%) reported starting supplements pre-conceptually and 118 (56%) only during pregnancy. However, 22 (18%) of women reporting supplement use in pregnancy stated that this was taken intermittently. Multiparous women were significantly more likely (P<0.05) to report not having taken the supplement at any time (17.1%) compared to primiparous (7.5%) A total of five focus groups and three joint interviews were undertaken with 24 women. Their ages ranged from 19 to 40 years with equal numbers of primiparous and multiparous mothers. The rationale behind the recommendation was generally known (although folic acid was also thought to relate to enhancing chances of conception, reducing miscarriage and having a positive impact on development of healthy bones and intelligence). The message was often perceived to be lost in the abundance of pregnancy communications and it was reported that it was rarely stressed by health professionals. Participants reported a perceived link between folic acid use and morning sickness, and also invoked busy lives, competing priorities and poor memory in accounting for intermittent use. Building a 'lay evidence base' from their own experiences, many cited healthy pregnancy outcomes without supplement use and expressed scepticism about its preventive action. The results provide guidance on areas that should be incorporated into future programmes including the importance of daily folic acid supplement use, the severity of NTD and the evidence on risk reduction. The importance of the inter-partum period is also highlighted.


BACKGROUND AND OBJECTIVES:
Adjuvants to local anaesthetics for brachial plexus block enhances the quality and duration of analgesia. Midazolam, a water-soluble benzodiazepine, is known to produce antinociception and enhance the effect of local anaesthetics when given epidurally or intrathecally. The purpose of this study was to assess the effect of Midazolam added to brachial plexus block by supraclavicular approach.
METHODS:
A prospective, randomized, single blinded study was conducted on 100 ASA I or II adult patients undergoing upper limb surgeries under supraclavicular brachial plexus block. Patients were randomly divided into two groups. Patients in Group B (n = 50) were administered 30mL of 0.375% Bupivacaine and Group BM (n = 50) were given 30mL of 0.375% Bupivacaine with Midazolam 2.5 mg. The onset time and duration of sensory and motor blockade were recorded. Hemodynamic variables (i.e., heart rate, noninvasive blood pressure, oxygen saturation), sedation scores and rescue analgesic requirements were recorded for 24 hr postoperatively.
RESULTS :
The onset of sensory and motor block was significantly faster in Group BM compared to Group B (P < 0.05). Rescue analgesic requirements were significantly less in Group BM compared to Group B (P < 0.05). Haemodynamics and sedation scores did not differ between the two groups in the post-operative period.
CONCLUSION:
Midazolam (2.5mg) in combination with 30mL of Bupivacaine (0.375%) hastened onset of sensory and motor block, and prolonged postoperative analgesia when used in brachial plexus block, without producing any adverse effects.


Selenium (Se) is a trace element used by multiple enzymes. In ruminants, Se present in food is released to ruminal fluid allowing its absorption in the small intestine. Se release may be analysed by hydride gener ation atomic absorption spectroscopy (HG-AAS). According to the Association Official of Analytical Chemists (AOAC), analysing the methodological performances is important to support the results of a methodology. The aim of this study was to develop and verify the analytical methodology of Se determination in ruminal fluid by HG-AAS. According to the AOAC guide, the parameters to be analyzed, and their respective acceptance crite ria (AC) are: applicable range (AC: 0.220 - 9.68 µg/l), bias (AC: 70-125%), precision by repeatability (RSDr%) (AC: < 21%), intermediate precision (RSDip%) (AC: < 21%), recovery (AC: 80-110%), limit of detection (LOD) (AC: < 0.22 µg/l), and relative uncertainty (AC: <15%). The technique used is based on a wet digestion of ruminal fluid with HClO 4 , H 2 SO 4 and HNO 3 concentrated at temperatures ranging from 120°C to 180°C. Then the digest was pre-reduced in HCl at 50 % and was quantified in the HG-AAS. The results obtained were: LOD 0.196 µg/l, bias 96.8% (1.25 µg/l); 98.3% (2.50 µg/l); 94.8% (5.00 µg/l), precision by repeatability 8.61% (3.28 µg/l); 8.90 % (3.52 µg/l); 9.80% (1.85 µg/l), intermediate precision RDSip 10.2%, recovery 109.2% (10 µg/l); 96.7% (25 µg/l); 96.8% (50 µg/l) and applicable range 0.196-62.5 µg/l. The values obtained are within the requirements stated by the AC. to evaluate are: applicable range, bias, precision by repeatability, intermediate preci -sion, recovery, limit of detection (LOD) and relative uncer -tainty, all of which will be defined later.


In this work, objective was to evaluate the capacity of a Rietema kind of hydrocyclone, with 50 mm diameter, to retain suspended sand in irrigation water. The hydrocyclone was operated with pressure differentials that varied from 10 to 60 kPa and discharges between 1,159.90 and 2,603.60 L h-1. The sand concentration in suspension varied from 2.81 to 7.01 g L-1. The best results were obtained for the pressure differentials of 10 and 20 kPa, with cut diameter sizes of 50 mm showing granulometric efficiency of 70%.


Diet and helminth fauna were analysed in Gallotia stehlini (Schenkel, 1901), a giant lacertid lizard endemic to Gran Canaria (Canary Islands, Spain) in order to explore eventual relationships between both traits. This species is mainly herbivorous, eating a large proportion of plant matter (occurrence 97.1%) including not only seeds but also leaves and other vegetative parts. Helminth fauna included many helminth species typical of herbivorous reptiles, and intestinal helminth diversity was high. A comparison with other lacertids suggests that both traits, diet and helminth fauna, result from an adaptation to insular conditions. Canarian Gallotia, a separate lineage evolving for a long time in insularity, constitutes the most modified lacertid group in this sense.


Purpose: To introduce a suture needle (Endoneedle) designed for laparoscopic extraperitoneal closure of patent processus vaginalis (PPV). Methods: The Endoneedle consists of 19-gauge hollow needle with a notch near the tip and 2-0 nonabsorbable suture and a plastic sheath. The procedures are performed with the help of a 5-mm telescope inserted through the umbilicus, and a 2-mm Endograsp placed below the umbilicus. Results: Since July 1998, this procedure has been carried out in 61 girls aged 3 months to 14 years. There have been no postoperative complications, and no recurrent hernia. The surgical wounds completely disappeared. In the most recent 10 cases, the mean operative time was 21 minutes for unilateral and 28 minutes for bilateral closure. Conclusion: This procedure is easy and safe, and it has excellent cosmetic results.


Abstract : A series of greases were prepared from the residue of the synthesis of synthetic fatty acids (acid number 103 mg KOH/g), C5-C9 acids (280 mg KOH/g), and acid water (248 mg KOH/g); the dispersion medium was a mixture of Z spindle oil and S machine oil. This composition corresponds to that of commercial synthetic grease. It was found that a change in the water content of the greases in the range of 1 to 5% does not affect their volume mechanical properties or structure, indicating that it is desirable to raise the water content of such greases to 4-5%. The structure of hydrated calcium lubricants prepared from soaps of narrow fractions of heat-treated and distilled synthetic fatty acids and their mixtures differs from the structure of fatty and synthetic greases in that it consists of rod-shaped, petal-shaped, and flaky soap crystallites. The greatest thickening capacity is displayed by C16-C20 acids with an average molecular weight of 286-300 and a purity of the fraction of no less than 90-95%. A wide boiling fraction of C13-C22 acids with a purity of no less than 98% is recommended for practical application and for producing high-quality synthetic grease. (Author)


This article dwells upon the methodological aspects of historical competences development in teaching future bachelors of history as exemplified in the course of Regional Studies Through History.


We discuss the charged pion condensation phenomenon in the linear sigma model, in the presence of an external uniform magnetic field. The critical temperature is obtained as a function of the external magnetic field, assuming the transition is of second order, by considering a dilute gas at low temperature. As a result we found magnetic anti-catalysis in the Bose-Einstein condensation for lower values of the external magnetic field, and catalysis for higher values of the external magnetic field. This behavior confirms previous results with a single charged scalar field.


Due to the turbulent business environment, small and medium-sized e-commerce companies tend to adopt a strategic logic that requires the support and co-evolution of organisational agility capability and information technology (IT) competence. However, the characteristics of organisational agility and IT competence and their co-evolution mechanisms are largely unknown. Based on the Sambamurthy et al. (2003), theoretical framework about the strategic logic for firms in a turbulent business environment, we undertook a case study of ten entrepreneurial e-tailers (retailers selling primarily on the internet) on a third party Chinese e-commerce platform. From these firms we identified the characteristics and the evolutionary path of entrepreneurial actions, organisation agility and IT competence for small and medium-sized entrepreneurial actions, organisation agility and IT competence from the perspective of real options and adaptive learning. This research advances our current understanding of SME e-commerce firm strategic logic and required firm capabilities.


In the 1950s, digital designers noted that residue number systems offer the attractive feature of carry-free addition, subtraction, and multiplication. This interest waned, in part because residue number systems possess a multi-state character; flip flops and other binary state devices lend themselves more naturally to binary arithmetic than to multi-state arithmetic. Optics enjoys the requisite multi-state capability: lenses can resolve many discrete positions, gratings can resolve many discrete frequencies, and so forth. This fact has motivated efforts to create a residue based optical processor, which would combine the parallel, speed of light throughput of optics with processing accuracies possible only to digital systems. Our program has included the identification of appropriate roles for residue processors, the investigation of I/O techniques, such as analog to residue and residue to radix conversion, and the study of optical implementations of residue arithmetic.


The disclosure of a sexual ambiguity is always a deeply distressing moment in someone's life. Usually, this disclosure results in a real trauma both to the subject and his/her family. The purpose of this article is to analyse the psychological consequences of such an announcement through the experience of three patients who were confronted to their intersexuality at different ages (birth, adolescence and adulthood). In each case, the subject is unable to integrate the opposition between psychological and biological reality. The strong belief of belonging to one specific gender (adolescents, adults) or of having given birth to a sexually determined child, generates a denial of that contradiction. This massive denial process allows the patient to overcome the trauma. Certainty of belonging to one's gender allows the reorganisation of psychological representation. This article focuses on the evolution of this defensive process. © 2008 Elsevier Masson SAS. Tous droits reserves.


The orientation character of dipole transition moment of ether solution was studied by polarization fluorescence spectrum and polarization excitation spectrum,in which there is a fluorescence peak at 305nm whose optimal excitation wavelength is 256 nm.According to the polarization excitation spectrum,the change rule of the angle α between the fluorophore's absorption transition moment and emission transition moment is obtained,and then the process of fluorescence depolarization is uncovered:the fluorescence molecule has a certain orientation in a highly viscous solution;the angle α is changing with different excitation wavelengths,as the more the excitation light is close to the optimal excitation wavelength,the more the absorption transition moment will parallel closely to emission transition moment which resulted in a weak depolarization and the biggest polarization ratio.The research can provide a reference for the theoretical study on the molecular character.


Mangroves are one of the most productive natural ecosystems and form an important part of the coastal and estuarine ecosystem and are nursery ground for many organisms'. Phenols are one of the major groups of secondary metabolites in plants. Phenolic acids in soil are naturally formed during humic acid breakdown. Oilier sources in sediment are flavanoids leached from plant debris, those formed during lignin decomposition and those synthesized by soil microorganisms


This paper proposes an innovative simulation software-based approach for wireless power transfer circuit modeling. The main characteristic of the methodology is the extraction of an equivalent circuit for a given positioning of the coils for a precise estimation of the losses. An important feature of the modeling is the estimation of the type of loss (conduction, eddy current and core) and their location (TX/RX winding or TX/RX core). All power losses will be represented as power dissipated by resistors present in the circuit model generated by the software. The modeling approach is tested by the comparison of loss prediction with the measurements of a 10 W wireless power transfer system in alignment and misalignment condition of the coils.


The ACT2 gene, encoding one of eight actin isovariants in Arabidopsis, is the most strongly expressed actin gene in vegetative tissues. A search was conducted for physical defects inact2-1 mutant plants to account for their reduced fitness compared with wild type in population studies. Theact2-1 insertion fully disrupted expression ofACT2 RNA and significantly lowered the level of total actin protein in vegetative organs. The root hairs of theact2-1 mutants were 10% to 70% the length of wild-type root hairs, and they bulged severely at the base. The length of the mutant root hairs and degree of bulging at the base were affected by adjusting the osmolarity and gelling agent of the growth medium. Theact2-1 mutant phenotypes were fully rescued by anACT2 genomic transgene. When the act2-1mutation was combined with another vegetative actin mutation,act7-1, the resulting double mutant exhibited extensive synergistic phenotypes ranging from developmental lethality to severe dwarfism. Transgenic overexpression of the ACT7 vegetative isovariant and ectopic expression of the ACT1 reproductive actin isovariant also rescued the root hair elongation defects of the act2-1mutant. These results suggest normal ACT2 gene regulation is essential to proper root hair elongation and that even minor differences may cause root defects. However, differences in the actin protein isovariant are not significant to root hair elongation, in sharp contrast to recent reports on the functional nonequivalency of plant actin isovariants. Impairment of root hair functions such as nutrient mining, water uptake, and physical anchoring are the likely cause of the reduced fitness seen for act2-1 mutants in multigenerational studies.


In today's constantly changing business environment, organizations cannot battle entirely as individual entities. Increasingly, they must rely on effective supply chain management (SCM) to successfully compete in the global market and networked economies. A lirm positioned in a supply chain network must manage interactions in both upstream and downstream segments of this network. Ihe firm's upstream network includes its suppliers and all of the suppliers' upstream partners, whereas the downstream network comprises the firm's customers as well as all of the customers' downstream stakeholders. The objectives of the study were: to establish the benefits that last African Breweries l.td (F.ABL) has achieved as a result of the upstream and downstream integration of supply chain; to establish the challenges faced by FABI. as a result of upstream and downstream integration of supply chain and to establish the strategies employed by LABL in risk management as a result of upstream and downstream integration of supply chain. Ihe research findings revealed that FABI indeed has achieved numerous benefits as a result of successful integration of supply chain. It was also evident that the firm docs face Some challenges in the whole process of SCM and has pul in place sonic strategies to manage ihe risks as a result of upstream mid downstream integration of supply chain with its strategic partners. Ihe research recommends that internal integration of all functions within the firm to lie customer driven even before integrating the upstream and downstream of the supply chain as it will be vital to first create a good link within the firm's function before moving a head to link the firm with other stakeholders within the supply chains and ensure that the benefits can be identified and communicated to all stakeholders in the supply chains.


ABSTRACT New directions in research on youth transitions are examined, with particular reference to the research findings of recent studies from different countries. The convergence of evidence in the studies points to a significant shift of emphasis for the study of youth transitions and the need for a more interactive research process that enables the participants to articulate their own meanings and experiences. One limitation of the studies is that the participants are the 'successful' members of the generation, but it is clear from the evidence that the meaning of 'transition' has changed in ways that raise questions both about the links between social structures and individual agency and about new definitions of adulthood. Not only do we need to document in greater detail what transition means in the lives of this post-1970 generation, but also we need to ask how their new life-patterns are already responding to or shaping new forms of adulthood.


Objective To investigate the mutations of pncA gene in clinical isolates of Mycobacterium tuberculosis and the relationship between pncA gene and pyrazinamide(PZA)-resistance in Qingdao area. Methods From 76 clinical isolates of Mycobacterium tuberculosis,the routine culture and drug susceptibility detection were done by BACTEC-460 system,and the mutations of pncA gene detected by PCR-SSCP. Results Among the 76 isolates,44 strains were PZA-sensitive and 32 PZA-resistant by the BACTEC-460 system.With PCR-SSCP,18 strains displayed abnormal pncA SSCP profile,in which,13 were PZAe-resistant and five PZA-sensitive.Fifty-one strains displayed normal pncA SSCP profile,in which 14 were PZA-resistant and 37 PZA-sensitive. Conclusion Mutation of pncA gene might be one of the major molecular mechanisms in pyrazinamide-resistance of clinical isolates of Mycobacterium tuberculosis.PCR-SSCP appears to be a promising method for rapid detection of pyrazinamide-resistant Mycobacterium tuberculosis,preferable to the routine drug-susceptibility test.


IN education, we seem to keep reinventing the wheel. Often a teacher's "discovery" of some effective educational principle proves, upon reflection, to be so blatantly obvious as to be embarrassing. Basic laws, simple though they be, are what we need to keep reteaching ourselves. One such reminder presented itself this fall, upon the occasion of the opening of school and the start of my classes in American literature.


PURPOSE: To perform the subject shaking culture improved in efficiency by shaking culture of aerobic microorganisms, vegetable cells or animal cells using a mobile vessel of specific constitution to improve the gas exchange ability between the inside and outside of the vessel and between the culture solution and a gas in the vessel. CONSTITUTION: Firstly, a mobile culture vessel is made up from (A) a bag 7 where a corrugated bottom material 3 is put between two side materials 1, 2 facing to each other with the inner surfaces consisting of thermofusible synthetic resin layer and the side materials 1, 2 and the peripheries 5, 6 are mutually continuous, (B) a rigid sheet-like material 8 put in the bag 7, and (C) an opening 10 provided on the upper part of each of the side materials and closed with a filter 9 impermeable for sundry germs but excellent gas feed ability. Thence, the corrugated part of the bottom material 3 is pressed by the sheet-like material 8 and flattened along with preventing the corrugated part from restoring through the rigidity of the sheet-like material 8, and the bag 7 is filled with a culture solution. Subsequently, the opening 14 of the bag 7 is sealed using e.g. a relevant jig 12 followed by carrying out shaking culture. COPYRIGHT: (C)1993,JPO&Japio


Background: Immunophenotypic characterization of acute leukemia's (AL) is an important clinical application of flow cytometry (FCA) and has become a powerful tool contributing to the diagnosis and classification of acute leukemia's. Objective: To compare the morphological and cyto- chemical diagnosis of peripheral blood and bone marrow sample with flow cytometric immunophenotypic diagnosis in acute leukemia's.


During "The Great Cultural Revolution" period,out of love and admiration for Chairman Mao Zedong,some mass organizations and work units compiled and reprinted many internal materials of Mao Zedong's biography.Due to its many editions and large numbers,it was quite difficult to make a precise statistics.However,among such many editions,there were reprinted Mao Zedong's Autobiography by Edgar Snow,Comrade Mao Zedong and His Youth by Xiao San,Chairman Mao's Revolutionary Activities by Ma Yuqing,and Sailing the Seas Depends on the Helmsman by "Songdong Writing Group".Among these texts of Mao Zedong's biography,except both Snow's and Xiao San's work,other books did have things like individual worship.But,considering it from another angle,it is of much referential value to study Mao Zedong's biography of this period,which will help us to study Mao Zedong's life and thought completely and systematically.


ABSTRACT A very brood class of end-point control problems is formulated in general terms, and correspondingly general procedures in the calculus of variations are developed for their solution The generality of the treatment lies in a systematic application of the point of view of functional analysis. The state of the system being controlled is described by an abstract vector in a suitable linear space ; the evolution of the system state with time is described in terms of an operator on the state vector ; the measure of system performance to be maximized or minimized is taken as a functional of the final state. The linearized system operator and its adjoint with respect to an inner product in the state space play central roles in the variational arguments The variational methods are in the spirit of those leading to the familiar Pontrjagin maximum principle, and indeed this principle appears as the finite-dimensional case of the present results. These results however apply equally to infinite-dimensional c...


Various lamb-based processed products have become popular in many countries, including Indonesia that are well known for lamb satay, lamb curry, grilled lamb, and others. Processing lamb meat into sausages is a potential alternative to diversify lamb-based processed food. This study aims to develop a lamb-based processed product in form of emulsion sausage. We used mixed lamb meat and fat of Batur lamb (0, 5, 10, 15, 20 and 25%) that was coarsely ground and added with 2.0% salt, 0.5% dextrose, 0.5% garlic powder, 0.5% pepper powder, 0.3% paprika powder and 0.5% chili powder. Meat, fat, and other ingredients are mixed evenly and then put into collagen casings and measured 10-cm long. Next, the sausage was steamed for +45 minutes, then cooled and drained. We used an experimental method with a Completely Randomized Design (CRD) assigning 6 treatments and 4 replicates. The treatments included T0: Lamb sausage without fat; T1 : Lamb sausage + 5% fat; T2 : Lamb sausage + 10% fat; T3 : Lamb sausage + 15% fat; T4 : Lamb sausage + 20% fat and T5 : Lamb sausage + 25% fat. The observed characteristics of sausages were chemical content (moisture, protein, fat, and ash content) and organoleptic properties (preferred colour, aroma, texture, taste, and acceptability). F test (anova) results showed that the treatment had a significant effect (P<0.05) on the moisture, protein, fat, and ash content of lamb sausage, as well as on preference for colour, aroma, texture, taste, and acceptance of lamb sausage. The results showed that the addition of 10% lamb fat produced emulsion-type lamb sausage with the most optimal characteristics, containing 63.290% water, 15.245% protein, 12.518% fat and 2.536% ash. The preferred colour, aroma, texture, taste and acceptance have satisfied the neutral criteria.


EdwardⅡ, the king of England was deposed by parliament in 1327. Some historian praised it as"constitutional revolution of 1327". The conclusion that it was only a palace coup can be reached through reviewing the history of England during the EdwardⅡ ruled(England suffered from economic crisis,political chaos and foreign aggression) especially the deposition process and analyzing the relations between king and parliament, aristocrat and law. It was impossible to appear modern"constitutional revolution"in England in the beginning of 14th century.


Analyzed is the thermostable performance changing rules of several kinds of powder for oil/gas well with the classical thermal decomposition theoretical analysis of gunpowder.For the special experimental conditions with high temperature,high pressure and relatively sealed intervals in oil/ gas wells,proposed are a set of experimental devices and methods for testing the powder high-temperature nature,the devices and the methods for detecting the combustion properties of powder and the analysis method for high temperature properties of powder.Carried out systemically are the high temperature behavior tests and analysis for several kinds of powder commonly used in oil/gas wells and similar alternatives.The results show that under high temperature conditions,the powder burning rates accelerate,their peak pressures increase,affecting the safety of operations;and the powder energy reduce or even failure,affecting the perforating effects in operation.Understanding of the powder′s thermostable performance changing rules can enhance the establishment of the powder performance detection.


Leaf rust is one of the three wheat rusts and is economically important disease of wheat worldwide. It is a devastating disease that can cause significant yield losses especially in wheat growing regions of the world where environmental conditions are conducive. In Ethiopia, wheat leaf rust is one of the most important diseases in most wheat growing areas of the country where the yield loss due to its impact is reaching up to 75% in susceptible wheat varieties at hot spot areas. This review discusses recent information on economic importance, epidemiology, geographic distribution, life cycle, host range of wheat leaf rust disease as well as its management methods such as cultural, chemical, biological and use of host resistance cultivars. Under the use of host resistance method, information on the types of resistance and sources of resistance has been presented.


Hedyotis tonggulingensis is described as a new species from China. It is similar to the sympatric species H. hainanensis, but obviously differs in having tetragonal stems with narrow wings, terminal and axillary inflorescences and the short corolla tubes. The phylogenetic analysis revealed that H. tonggulingensis was closely related to the sympatric species of H. pardifolia and H. yazhouensis but not to H. hainanensis. It was evaluated as Least Concern because of its abundant individuals, little economic use and well protected habitat.


In many low- and medium-income countries that are the traditional sources of international migrants, total fertility rates have dropped to levels at or near replacement. In this context of low fertility, we expect migration's effects on fertility to operate primarily through marital timing and marital stability. We examine the effects of international migration on age at first marriage, union dissolution, timing of first birth, and completed fertility, using retrospective life-history data collected in Mexico and eight other Latin American countries by the Mexican Migration Project (MMP) and the Latin American Migration Project (LAMP). Using discrete-time hazards and Poisson regression models, we find clear evidence that early migration experience results in delayed marriage, delayed first birth, and a higher rate of marital dissolution. We also find evidence among women that cumulative international migration experience is associated with fewer births and that the estimated effects of migration experience are attenuated after taking into account age at union formation and husbands' prior union experiences. As fertility levels in migrant origin and destination countries continue on their path toward convergence, migrant fertility below native fertility may become more common due to migration's disruptive effects on marital timing and marital stability and the selection of divorced or separated adults into migration.


Aimed at the production characters and problems which exist in gasoline fractionator in large-scale ethylene units,high strength three-pass tray technology is exploited.The performance experiments and the computational fluid dynamic(CFD) calculation for the three-pass tray are conducted.The results show that liquid grads and flow pass in the three-pass tray are reduced,and the distributions of gas and liquid are more uniform.After its industrial application in Qilu Company Ltd.,SINOPEC,which the production capacity of ethylene is 720kt/a,it shows that the main performance parameters of the gasoline fractionator are consistent with the designed value,which can meets the production requirement for ethylene.


Let b be even,this paper discusses necessary condition and sufficien condition for generalized Fermat number F(b,n)=b2n+1 to be composite number.


Against the problem of silicon increased much more in refining production of low-silicon low-sulfur aluminium killed steel for cold-rolling with LF furnace in No.3 Steelworks of Han Steel,its limited production steps are analyzed,new refining process worked out,and so the ratio of qualified melting steel obviously increased.


The experimental results indicate that irradiation of microwave is efficient for regenerating the resin(NDA-150)absorbing o-nitro-phenol when using dilute alkali solution as a desorbent,and the irradiation in a short interval for several times can avoid the "hot spots" phenomenon.The desorption efficiency of o-nitro-phenol mildly increases as the irradiation time by microwave increase,but rapidly increases with rise of concentration of alkali.


Motivated by the remanufacturing industry practice, a refurbishing system, composed of a collection center and a refurbishing center, is studied, where the refurbishing and inspecting costs are dependent on the quality of returned items. First a stochastic profit model is formulated, to make decisions on how many returned items are collected and what quality levels of the returned items are refurbished, so as to maximize the total expected profit. Then we prove the existence and uniqueness of the optimal solution of the acquisition quantity and derive the formulation of the optimal solution. Finally, numerical examples are provided to validate the results and show the impact of quality on acquisition policy.


This paper deals with an enhanced Direct Torque Control strategy for induction motor drive. The proposed approach uses a more precise switching table based on twelve sectors and modified hysteresis controllers. Processor In the Loop technique is performed using MATLAB with Code Composer Studio and F28069M development board. Therefore, this work proposes an experimental validation of an enhanced algorithm for Direct Torque and flux Control. Also, it offers a comparison to the conventional Direct Torque Control strategy. Processor In the Loop results, show that modified Direct Torque Control strategy improves torque and flux dynamic and enhances waveforms quality. So flux and torque ripples and harmonic distortion of the currents are reduced.


A 44-year-old immunocompetent woman was treated for methicillin-resistant Staphylococcus aureus causing abdominal wall cellulitis with incision/drainage and intravenous daptomycin delivered via a midline catheter. The patient presented 5 days later with abdominal pain and spiking fevers. A chest x-ray demonstrated a new right upper lobe infiltrate, and the blood culture grew Serratia rubidaea. The midline catheter was removed, and the patient was successfully treated with intravenous ceftazidime with clinical and bacteriological resolution. This case emphasizes the need to consider unusual species of Serratia in nosocomial sepsis.


We present an outer bound for the discrete memo-ryless two-way multiple access broadcast channel (TW-MAC/BC) using the dependence balance idea. The cut-set outer bound for multi-user channels allows arbitrarily correlated input distributions while the dependence balance idea limits the set of arbitrarily correlated input distributions to those satisfying a specific constraint known as dependence balance bound, which is particularly useful in channels with feedback or adaptation, as in two-way channels. We obtain a general dependence-balance-based outer bound for the discrete memoryless TW-MAC/BC, and a parallel channel extension for the single-output channel. We then show that for the single-output binary additive noisy TW-MAC/BC Y = X1 + X2 + X3 + Z (Z Bernoulli(0.5)), an outer bound to the symmetric sum-rate of our outer bound is strictly smaller than that of the cut-set outer bound. This is shown using the composite function technique introduced by Willems and used by Tandon and Ulukus in the context of multiple-access channels with feedback.


Background. Use of community health workers (CHWs) to increase access to diagnosis and treatment of malaria is recommended by the World Health Organization. The present article reports on training and performance of CHWs in applying these recommendations. Methods. Two hundred seventy-nine CHWs were trained for 3–5 days in Burkina Faso, Nigeria, and Uganda, and 19 were certified to diagnose and treat only uncomplicated malaria and 235 to diagnose and treat both uncomplicated and severe malaria. Almost 1 year after training, 220 CHWs were assessed using standard checklists using facility staff responses as the reference standard. Results. Training models were slightly different in the 3 countries, but the same topics were covered. The main challenges noticed were the low level of education in rural areas and the involvement of health staff in the supervision process. Overall performance was 98% (with 99% in taking history, 95% in measuring temperature, 85% for measuring respiratory rates, 98% for diagnosis, 98% for classification, and 99% for prescribing treatment). Young, single, new CHWs performed better than their older, married, more experienced counterparts. Conclusions. Training CHWs for community-based diagnosis and treatment of uncomplicated and severe malaria is possible with basic and refresher training and close supervision of CHWs' performance. Clinical Trials Registration. ISRCTRS13858170.


WOMEN OF NO IMPORTANCE: THE ONTARIO PAY EQUITY ACT AND LOW PAID WOMEN The Ontario Pay Equity Act has been hailed by many as the most progressive pay equity legislation thus far enacted in that it is the first proactive scheme to apply to both the public and private sectors. For many women in the Ontario labour force, however, it is entirely irrelevant. In analyzing the Act I draw on the recent work of anti-essentialist and postmodern feminist legal theorists who are critical of previous scholarship for excluding the voices of many women by ignoring central aspects of their being race or ethnicity for example and focusing exclusively on their gender. Applying these theoretical approaches to a concrete area of law requires an anti-essentialist understanding of human identity and the use of shifting standpoints; the scrutiny of the influence of specific policies, laws and cases on particular groups of women. I analyze the provisions of the Pay Equity Act in relation to those women who are becoming more marginalized in the labour market as a result of global economic restructuring, especially low paid women. In Canada, these changes have translated into the decline of manufacturing industries and growth in the service sector and an increasing


AbstractIn continuing our studies on Corydalis Medik. (Papaveraceae, subfamily Fumarioideae) growing in Turkey, from which isoquinoline alkaloids have been isolated, we now report the isolation of (+)-fumaritine, (+)-fumariline, (+)-ochotensimine, (-)-corpaine and (±)-sibiricine as well as other isoquinoline alkaloids from Corydalis caucasica DC. The isolation of (+)-fumaritine represents is the first report of the naturally occurring enantiomer of the known (-)-fumaritine. The absolute configuration was established through a study of CD spectra. (+)-Fumaritine and (+)-fumariline are monooxygenated in ring C; while the known (-)-corpaine and (±)-sibiricine are dioxygenated. (+)-Fumariline, (-)-corpaine and (±)-sibiricine were further characterized their sodium borohydride reduction products.


The progress of modern nanoelectronics, optoelectronics, nanophotonics, and microoptics is determined mainly by nanolithography advances. The electron beam lithography tools possessing a few nanometers resolution and good flexibility have a good outlook for creation of devices of this type. From the electron beam lithography tools only tools with sharp focused beam may be used for pattern generation over nanoscale area, but the writing speed thereof may decrease dramatically as the beam diameter d is reduced as d--6 over this area. The theoretical analysis showed that the application of electron beam monochromator could not only improve resolution, but increase also the beam current over the minimum diameter area. Numerical modeling of heating process under scanning by electron beam is performed also to fit the electron lithography systems and scanning electron microscopy. Areas of safe work with sensitive to heating samples are determined. A conditions and prospects of development of the various electron beam lithography systems are considered. The achievements of electron beam lithography are compared with success in the field of other lithography techniques.


The adoption of Cloud Computing technologies by the organizations has profound consequences on the way software applications are developed and used. The migration to the Cloud may be accompanied by the revision of the business process, to integrate tasks over big data. In this way, existing workflow implementations may be extended with calls to operations in Hadoop or other tools. In this work, we define a framework to implement business process over heterogeneous technologies. Our framework is based on a novel workflow engine, called μBP-AM. Workflow execution in μBP-AM is performed by successively transforming the graph obtained from a workflow definition. μBP-AM has a formal semantics, which gives a precise definition of how the workflow is implemented. μBP-AM is at the core of an extensible framework capable of supporting not only Web service operations but also Hadoop operation calls (among others). The tool described here was conceived to increase reliability and to promote interoperability. We describe a prototype implementation of our framework, as well as some experimental results. Experiments using this prototype show that compositions run in μBP-AM using about the same resources as those run by using other tools.


Toshiya Kaihara received the BE and ME degrees in precision engineering from Kyoto University, Kyoto, Japan, in 1983 and 1985, respectively. He received the PhD degree in mechanical engineering from Imperial College, University of London, London, UK, in 1994. After joining Mitsubishi Electric Corp. in 1985, he moved to the Computer and Systems Engineering Department in Kobe University, Japan, as an associate professor in 2001. Currently he is a professor at Graduate School of Engineering in Kobe University. His research interests include theory and implementation on sociological multi-agent paradigm, and its application into manufacturing /distribution systems. He is a member of Japan Society for Precision Engineering, Japan Society of Mechanical Engineers, Operations Research Society of Japan, IFIP, IEEE, and many others.


Objective To explore the clinical effects of hyperbaric oxygen treatment for postoperative hypertensive cerebral hemorrhage. Methods 168 cases of postoperative patients with hypertensive cerebral hemorrhage in our hospital from August 2008 to July 2012 were selected and randomly divided into control group(70 cases) and treatment group(98 cases).The control group were given with comprehensive clinical treatment,the treatment group were given with hyperbaric oxygen treatment on the basis of comprehensive clinical treatment.The clinical effects,incidence of complication and sequela were compared between the two groups. Results The total effective rate was 91.8% and77.1% in the treatment group and the control group respectively,with statistical difference(P0.01).The two groups had statistical difference in the incidence of complications and sequelae(P0.05). Conclusion Conventional hyperbaric oxygen treatment for postoperative hypertensive cerebral hemorrhage plays an important role in improving the curative rate and reducing complications and sequelae.


BER Performance of Multi-Code Biorthogonal Code Select CDMA system is shown in this paper. MC Biorthogonal CS/CDMA system employs truncation scheme to make binary signals so that it can reduce the value of peak to average power ratio(PAPR). Thus, this system enables to realize cost-efficient and power-efficient RF modules, still maintaining good overall BER performance. However, the nonlinear characteristics of Clipping cause some randomness in specific signal-to-noise ratio. Lloyd-Max Quantization is compared with Clipping for performance improvement. BER performance is shown in AWGN and multi-path fading channels.


Objective To induce islet grafting tolerance by intravenous injection of anti-CD4,anti-CD8 immunotoxins and donor soluble antigen.Methods 14 days or 7 days prior to transplantation,the immunotoxon 200 μg respectively,and donor soluble antigen 500 μg were injected intravenously into the recipients, then 500 donor islets were translanted under the left renal subcapsular space of diabetes reciPients (SD rats).Results The islet grafting survival time that pretreated with immunotoxon and dono soluble antigen was over 60 days(P<0.01).The immunotoxins or donor soluble antigen treatment alone only slightly prolonged the graft survival.Conclusion The anti-CD4,anti-CD8 immunotoxins combined with donor soluble antigen can induce donor specific immune tolerance.

Key words:
Immunotoxin; Donor soluble antigen; Islet/transplantation; Immune tolerance


Voltage fluctuation is depicted as a sequence of root mean square voltage changes or a cyclic difference of the voltage waveform envelopeThe non-resistive loads used in the power system are the major source of fluctuation. Such fluctuating loads include arc furnaces, rolling mill drives, and main winder. All of these have loads with a high rate of change of power with respect to the short-circuit capacity at the point of common coupling (PCC). Small power loads also can be sources of flicker, such as starting of induction motors, welders, boilers, power regulators, electric saws and hammers, pumps and compressors, cranes, and elevators. In power systems, a number of harmful technical problems occur due to voltage fluctuation, resulting in disturbance to production processes and considerable costs. But flicker has its negative physiological results, which can affect worker safety as well as productivity. This paper represent various wavelets used for monitoring of Fluctuation and Flicker.


BACKGROUND
Hypersensitivity pneumonitis (HP) is an inhaled antigen-mediated interstitial lung disease (ILD). Advanced disease may necessitate the need for lung transplantation. There are no published studies addressing lung transplant outcomes in HP. We characterized HP outcomes compared with referents undergoing lung transplantation for idiopathic pulmonary fibrosis (IPF).

METHODS
To identify HP cases, we reviewed records for all ILD lung transplantation cases at our institution from 2000 to 2013. We compared clinical characteristics, survival, and acute and chronic rejection for lung transplant recipients with HP to referents with IPF. We also reviewed diagnoses of HP discovered only by explant pathology and looked for evidence of recurrent HP after transplant. Survival was compared using Kaplan-Meier methods and Cox proportional hazard modeling.

RESULTS
We analyzed 31 subjects with HP and 91 with IPF among 183 cases undergoing lung transplantation for ILD. Survival at 1, 3, and 5 years after lung transplant in HP compared with IPF was 96%, 89%, and 89% vs 86%, 67%, and 49%, respectively. Subjects with HP manifested a reduced adjusted risk for death compared with subjects with IPF (hazard ratio, 0.25; 95% CI, 0.08-0.74; P = .013). Of the 31 cases, the diagnosis of HP was unexpectedly made at explant in five (16%). Two subjects developed recurrent HP in their allografts.

CONCLUSIONS
Overall, subjects with HP have excellent medium-term survival after lung transplantation and, relative to IPF, a reduced risk for death. HP may be initially discovered only by review of the explant pathology. Notably, HP may recur in the allograft.


The construction item refers to a program completed by a contractor in a whole process from the commencement of bidding for the project to the expiration of service.In view of the item management of highway construction,this article discusses the whole process of construction management,including planning,organizing,supervising,controlling and coordinating,etc.


Random fluctuations in genetic networks are inevitable since chemical reactions are probabilistic and many genes, mRNAs and proteins are present in low numbers per cell. Such 'noise' affects all life processes and has now been measured directly using green fluorescent protein (GFP). Two studies show that autorepression of replication or transcription suppresses noise and three others4 identify the sources of noise in gene expression – separating the contributions from transcription, translation and the intracellular environment. But they disagree both biologically and mathematically. Here I present a single equation that unifies the mathematical perspectives and resolves the experimental controversies. This connects Biochemical Systems Theory to the fluctuation-dissipation theorem and concepts like susceptibility, time-averaging and disorder.


A case of mycotic placentitis with abortion in a mare in the 7th month of gestation is described. Gross changes included an underdeveloped fetus, patch whitish areas in the placenta and thickenning of the allantochorion. In the fetal lungs there were nodules of 1 cm diameter. Histopathological changes consisted mainly of necrosupurative placentitis with multifocal mineralization on the placenta and thrombosis with focal supurative inflamation in the fetal lung. Branching, septaded fungal hyphae could be demonstrated in the placental lesions and in the lungs of the fetus. Aspergillus fumigatus was isolated from the placental lesions. Diagnosis was based on the histopathology and isolation of the agent.


Bridge pier scour engendered by typhoons or flooding poses a threat to the stability, bearing capacity, and other performance parameters of bridge foundations. In traditional static evaluation procedures, linear force distributions are used to express the fluid behavior under current forces, which results in overestimation of stability. A finite element simulation was conducted in this study to correctly evaluate the effect of fluid by developing a fluid-solid interaction (FSI) system. In the FSI system, simulation results for both the fluid and solid systems were exchanged. Thus, the force generated by the fluid system could be incorporated into the solid system to estimate the dynamic response of a pier. A scaled single-pier scour test was first conducted numerically and experimentally. The results showed that the established FSI system can consider the fluid-solid interaction and reflect pier scour behavior accurately. To test the validity of the proposed system, the scour process was numerically conducted on an engineering bridge. Two safety factors were proposed to evaluate the stability of the bridge structure under extreme events such as rainfall or typhoon. The result has proven that the scour stability of the bridge pier can be appropriately evaluated by the proposed system.