Our object is Cartan connections with semisimple flat homogeneous spaces as standard spaces. We study these from the viewpoint of G-structures of second order. This allows us especially to treat classical projective and conformai connections in the unifying manner. We also consider its application to the problem of certain geometric transformations. Introduction. Let M be a manifold of dimension «. We denote by ^\M) the frame bundle of M, and by A(iF\M)) the set of all linear connections without torsion on 3P\M). The projective geometry of linear connections is the study of invariants of projectively equivalent classes in AQF\M)). It is the classical theory by E-. Cartan that for each projectively equivalent class there corresponds uniquely a projective Cartan connection [4]. Examining the algebraic structure of projective spaces, N. Tanaka introduced the notion of a /-system I and the homogeneous space Mi=L(T)/L0(l) [29]. Generalizing the notion of projective equivalence, he gave the notion of /-equivalence in the set A(P) of all G0(0-connections without torsion on a given G0(l) structure A over M, where G0(l) is the linear isotropy group of M=L(Í)/L0(Í). Then he showed that for each I-equivalence class there corresponds uniquely a Cartan connection of type Mi [29]. On the other hand S. Kobayashi and T. Nagano found that the projective equivalence is also defined by using the bundle &\M) of 2nd order frames of M [13]. And they reconstructed the above theory of E. Cartan [13]. Our first purpose in this paper is to rebuild the theory of N. Tanaka from the viewpoint of 2nd order structures, thus generalizing the results in [13]. The Spencer cohomology group of a graded Lie algebra plays an important role in the constructions. Next, we deal with the geometric tensors associated with our spaces. As one of the examples, a generalization of Weyl's projective tensors is given. It is proved that its vanishing is equivalent to the integrability of certain geometric structures. Received by the editors November 3, 1969. AMS 1969 subject classifications. Primary 5352, 5350, 5373.


. [Purpose] The purpose in the present study was to examine the possibility that virtual reality interactive exercise game can help relieve depression and improve the quality of life of elderly females with osteoarthritis. [Subjects and Methods] Forty elderly females suffering from knee osteoarthritis were randomly assigned to either an experimental group or a control group so that each group had 20 members. The experimental group played exercise game using Xbox 360 kinetic sensors for 30 minutes per session, three times a week for four weeks. The control group did not engage in this activity. The depression of the subjects was measured using the Korean version of the Short Geriatric Depression Scale (SGDS-K) and their quality of life was measured using SF-8. [Results] The experimental group's SGDS-K score after the exercise game intervention was significantly lower than that before the intervention and the experimental group's SGDS-K score was significantly lower than that of the control group. The experimental group's SF-8 score after the intervention was significantly higher than that before the interven tion and the experimental group's score was higher than that of the control group, although the differences were not significant. [Conclusion] The exercise game experiment using Xbox 360 kinetic sensors showed the possibility that such activities could help relieve depression and improve the quality of life of elderly females suffering from osteoarthritis. Further studies are necessary to determine the most effective methods and duration.


This document is the culminating product of a series of ad-hoc workshops led by a group of European and North American air quality scientists interested in instigating a significant advance in the way regional-scale air quality modelling systems are evaluated. The initiative arising out of these workshops has come to be known as the Air Quality Model Evaluation International Initiative (AQMEII). The motivation for the workshops was a growing sense that current model evaluation practices have stagnated, and as a result are not serving research, operational and policy sectors as well as they should. While technical (often statistical) approaches have advanced in the past two decades, it was felt that present approaches are too often uncritically applied, without due consideration of the foundations upon which the techniques are based. This document contains a set of research recommendations for advancing model evaluation. These recommendations are based on ideas generated during workshop presentations, group discussions and informal discussions that occurred at and around the workshops. How to obtain EU publications Our priced publications are available from EU Bookshop (http://bookshop.europa.eu), where you can place an order with the sales agent of your choice. The Publications Office has a worldwide network of sales agents. You can obtain their contact details by sending a fax to (352) 29 29-42758. The mission of the JRC is to provide customer-driven scientific and technical support for the conception, development, implementation and monitoring of EU policies. As a service of the European Commission, the JRC functions as a reference centre of science and technology for the Union. Close to the policy-making process, it serves the common interest of the Member States, while being independent of special interests, whether private or national. LB -N A -2445-EN -C


We analyzed the effects of the SARS‐CoV‐2 pandemic on neurologic emergencies, depending on the patients' triage score in a setting with relatively few COVID‐19 cases and without lack of resources.


The aim of this study is to verify and assure the presence or absence of lucanoid and scarabaeoid beetles in ecological cherry orchards and hence contribution to the fauna of Turkey. To fulfil this aim, a study was conducted in ecological cherry orchards in Muradiye (Manisa-Central province) (38 39' N / 27 20' E), Oren (IzmirKemalpasa) (38 28' N / 27 36' E) and Armutlu (Izmir-Kemalpasa) (38 25' N / 27 32' E), of western Turkey during the years 1998 & 1999. These beetles were collected mainly by bait traps and also pitfall traps as well as knock down methods were evaluated.


Urban mobility plays a key role in the ecosystems of complex smart cities. It is considered a key factor in enabling cities to become more intelligent, which highlights the importance of identifying the drivers that improve the intelligence of cities. In this study, we investigate the main drivers with the potential to increase urban mobility intelligence and assign them a priority. Following on from a systematic review of the literature, we conducted broad and detailed bibliographic research based on the recommendations of the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA). We also surveyed 181 professionals working in the field concerned to confirm the importance of different drivers and assign them a level of priority. The results show that 27 drivers identified in the literature were considered important, of which seven, related to city governance and technical solutions, were considered the most important to increase urban mobility intelligence.


AbstractThe use of computerized infra-red thermography is discussed in relation to the measurement of human skin surface temperat.ure. Numerical analysis of digitized thermograms enables quantitative descriptions of thermal patterns to be made which are now adding muc.h to our understanding of the mechanisms involved in physiological thermal processes. Examples are given of the way that such analysIs IS also becoming increasingly useful in clinical diagnosis and assessment.


SummaryThe effect of U.V.-irradiation of template DNA has been studied in vitro in the E. coli RNA polymerase system with native and U.V.-treated λ DNA. λ DNA is more susceptible to U.V. than is calf-thymus DNA, yet a residual activity is observed at a U.V. dose of 0·5 + 104 erg/mm2. From the kinetic analysis of the reaction and the incorporation of γ 32P-labelled nucleoside triphosphates, it seems reasonable to conclude that U.V.-irradiation probably does not affect the DNA initiation sites, recognizable by RNA polymerase. The transcription products made with U.V.-irradiated λ DNA are assymmetrical, and hybridized to the right half (R) and the left half (L) of λ DNA with the ratio of R/L = 4/1, and they show a lower hybridizability than the transcripts with native λ DNA. The initiation sites recognizable by RNA polymerase seem to be the same on both native and U.V.-irradiated λ DNA, though the transcription of U.V.-treated λ DNA appears to terminate with rather short RNA chains.


This essay examines the visit to Mexico in February 2000 by Erica-Irene Daes, then chairperson of the United Nations Working Group on Indigenous Populations. I use the occasion of this visit to analyze the relationship between a regional indigenous organization in the state of Guerrero, the Mexican national state, and the United Nations within the larger context of the development of international law. I argue that the persistence today of a centuries-old bias in international law that privileges the "nation-state" and a related individualistic bias in the conception of human rights make UN support for indigenous self-determination highly equivocal. I begin with an examination of the Consejo Guerrerense and how its experience helps to illustrate the issues confronted by the indigenous rights movement in Mexico today. Then I provide background to place this movement and the United Nations in the context of the development of international and human rights law. The discourse of international human rights an...


Reinforced concrete has been known to deteriorate due to chloride ingress for over forty years. In North America, Cathodic Protection was considered thirty years ago to prevent further deterioration of bridge decks but only when the effects of de-icing salts on roadways became apparent has the technique been considered for use in the United Kingdom. After five years of accelerated development, it is now possible in 1989 to look at the state of the cathodic protection engineering market. The results of research initiated in 1984 are beginning to become apparent; it is at last possible to refer to Standards and Specifications which find some acceptance in the industry and best of all, the actual experience of application of the technique to real structures is beginning to be reported at conferences and incorporated into contract documents.(A) For the covering abstract of the conference see IRRD 828897.


INTRODUCTION
Coronavirus disease 2019 to this day caused more than 6 million deaths worldwide. So far five variants of concerns have been identified with Delta and Omicron being the subject of our analysis.

OBJECTIVES
We aim to compare baseline characteristics and outcomes of patients hospitalized during Delta and Omicron predominance in Poland.

PATIENTS AND METHODS
The study population consisted of 2,225 patients divided into two groups depending on the variant with which they were infected during the corresponding period of the pandemic.

RESULTS
During the Delta wave, the median age of patients was significantly lower (65 vs. 73 years, p<0.001), and the cohort was significantly less burdened by comorbidities than during the Omicron surge. Omicron-infected patients presented significantly less often in an unstable symptomatic state with SpO2 ≤90% on admission (49.9% vs. 29.9%, p<0.001). Regardless of the pandemic period, the two most common early symptoms of COVID-19 were fever and cough. In-hospital treatment consisted of antiviral drugs, more frequently used in the Omicron wave, and immunomodulatory drugs more frequently used during the Delta wave. The risk of mechanical ventilation was significantly lower in patients infected with Omicron (7.2% vs. 3.1%, p<0.001).  For the age group >80 years the risk of death was significantly higher during the Delta wave as compared to Omicron wave. The risk of death was statistically significantly lower in patients treated with antiviral drugs regardless of the pandemic wave.

CONCLUSIONS
The Delta variant causes a more severe clinical course of the disease and a higher risk of death compared to the Omicron variant.


Cellular materials present interesting properties for application in design. Among the most well-known are cork and synthetic polymer alternatives, bio-inspired in the plant material. However, little has been studied about the relationship between microstructure and properties for applications in product design. This research aims the characterization and comparison of cellular materials through a case study of stoppers, with focus on material selection, and relating the relative density and porosity of the samples with techniques of scanning electron microscopy (SEM), thermogravimetry (TGA) and compression tests. The analyzes were carried out on samples of natural and agglomerated cork and synthetic alternatives of expanded polypropylene and EVA. SEM images show the replication of the cork cell pattern in synthetic alternatives. Compression tests were related and discussed regarding the mechanical properties and the cellular characteristics of the materials. How the microstructure of both natural and synthetic cellular materials directly reflects on their thermomechanical properties was discussed, as well as considerations in the materials selection for design projects. Additionally, it could be concluded that TGA analyses showed natural cork as a more homogeneous material in comparison to the agglomerate, whereas the synthetic samples were more resistant to thermal degradation.


This paper mainly researches the influence of the variety of target radar cross section(RCS) or active jamming power(the other conditions don't change)on radar burnthrough range and jamming effect under the self-defense jamming or support jamming mode,and draws the curves reflecting the relation between the burnthrough range and RCS active jamming power.


Chemical composition and nutritional studies of roselle seeds (Hibiscus sabdariffa) were performed. The results of amino acid analysis indicated roselle seed to be a potential high-protein source. Lysine content was found to be similar to that of the FA0 reference protein. The most limiting amino acids in roselle seed were found to be valine, isoleucine, and tryptophan. Also, the results of lipid analysis indicated roselle seeds to be a good source of lipid. Fatty acid analysis revealed that linoleic, oleic, palmitic, and stearic acid were the major fatty acid constituents. The most predominant inorganic elements in roselle seed were found to be K, Na, Mg, and Ca. Roselle seeds exhibited high digestibility by a trypsin-pancreatin system. Analysis of tannins and phytic acid in roselle seed revealed low levels. The results of Osborne classification indicated that the major protein fraction consisted of globulins. Also, roselle protein gave a sharp spectrum with a maximum absorbance at 272 nm. The present study showed that roselle seed proteins were highly soluble at acid and alkaline pH values, with a minimum solubility at about pH 4. Roselle seed meals had excellent foaming capacity, foam stability, and water absorption capacity.


In this paper we describe an eecient parsing model for monotonous xed-mode DCGs, including traversing of cyclic terms. The algorithm can be viewed as an extension of the classic push-down automaton model in dynamic programming along with the incorporation of a mechanism for detecting and traversing cyclic trees. Details of implementation and experimental tests are described. Experimental results show the performance of our approach.


Degree refinement matrices have tight connections to graph homomorphisms that locally, on the neighborhoods of a vertex and its image, are constrained to three types: bijective, injective or surjective. If a graph G has a homomorphism of a given type to a graph H then we say that the degree refinement matrix drm(G) of G is smaller than drm(H). This way we obtain three partial orders. Computing drm(G) is easy, so an algorithm deciding comparability of two matrices in one of these partial orders would be a heuristic for deciding if G has a homomorphism of given type to H. Both for the locally bijective and injective constraints there exists such an algorithm deciding comparability, and for the locally bijective constraint this gives a well-known heuristic for the special case of graph isomorphism. For the locally surjective constraint the existence of an algorithm deciding comparability has been posed as an open problem in [13]. We resolve this open problem by showing that it belongs to the complexity class NP.


In this paper, We propose a motion control algorithm of a mobile robot with dual arms for handling an object in cooperation with a human. The algorithm specifies the apparent impedance of a manipulated object with respect to a world coordinate system. It also specifies the apparent impedance of the mobile base with respect to the object coordinate system without the influence to the motion of the object to the base. The control algorithm is implemented in Mobile Robot Helper and experimental results illustrate the validity of the proposed algorithm.


ABSTRACT Between 1982 and 1991, we performed conservative operations on 11 women aged 23 to 39 years (mean 28 years) with extensive rectovaginal septum endometriosis. Before the intervention, severe deep dyspareunia was reported by 6 patients and moderate by 4, severe dysmenorrhea by 4 and moderate by 5, and severe acyclic pelvic pain by 2, moderate by 4, and mild by 1. The subjects underwent vaginoabdominal surgery with subtotal removal of the posterior vaginal fornix and excision of intraperitoneal endometriosis, with presacral neurectomy in 7 cases and low anterior rectal resection in 5. After a mean follow-up of 41 months, 6 women have no dyspareunia and 5 have mild discomfort, 4 have no dysmenorrhea, 3 have moderate and 4 mild menstrual pain, and 6 have mild acyclic disturbances. Three of nine infertile patients conceived. In selected young women wanting children, with pelvic pain symptoms unrelieved by medical treatment, a conservative vaginoabdominal surgical approach is feasible, and satisfactory ...


Growing demand for plant-based food is already a reality in the global food market. These foods serve groups of heterogeneous profile. However, far too little is known about the factors that influence their choice. Thus, the aim of this paper was to investigate the criteria involved in choosing plan-based foods from consumers in Fortaleza-CE and the metropolitan region. A market research was developed using a structured questionnaire inspired by the Food Choice Questionnaire, obtained in person, in a university cafeteria and a vegetarian restaurant, and online. The respondents were mostly composed of people between 18 and 35 years old, female and consumers of vegetable products daily. The questionnaire revealed metric property, with α values between 0.664 and 0.804. The criteria most important for the food choice to the respondents were "price" (6.12 ± 1.24) and "sensory appeal" (6.03±1.34). When comparing the consumer segments, the "weight control" criterion was more relevance for women. From the observations and analyzes made it, this research presents important information for the development of plant-based product market in the food industry with the criteria considered to be most relevant for their consumption.


Background: Children with Down syndrome are prone to respiratory tract infections, due to altered humoral and cellular immunity and a different anatomy of the respiratory tract. Otitis media is frequently seen in children with Down syndrome. Methods: The medical records of 204 children with Down syndrome were analysed to determine the frequency of otitis media and associated ear, nose and throat surgery, as well as hearing loss. Results: One or more episodes of otitis media were reported in 117 out of the 204 children (57%) examined in our study. It appeared to be especially common among the younger age groups. In our study group, 121 of the 204 children (59%) underwent ear, nose and throat surgery; of that group of 121, 90 children (74%) were operated more than once. Ninety-six of the 204 children (47%) underwent placement of ventilation tubes, with posterior otorrhea in 43 children (45%). In this study, 23% of the children suffered from hearing loss. Conclusions: Otitis media and ear, nose and throat surgery are common in our group of children with Down syndrome. The frequency of post-tympanostomy otorrhea is high.


The closed form solution of the Darboux boundary value problem, which occurs at the backward driving solids by the condensed explosive, was obtained in this paper. The constructed solution may be used, among other cases, for estimating the explosively driven elements velocity of the casing and liner of the wedge hollow charge. The solution may be applied for evaluation of the explosive active part in the wedge shaped charge, too. These problems will be considered in the next paper.


Objectives : To study antimicrobial susceptibility pattern in urinary bacterial isolates. Methods : A retrospective analysis was done for the resistance pattern of urinary bacterial isolates was done over a period of 2 years (July 2004 – 2006) in a tertiary care hospital. Results : Commonest isolates were E. coli (41.3%) followed by Klebsiella spp. (15.8%), pseudomonas spp. (11.4%), Enterobacter spp. (8%) and Proteus spp. (6.2%) in gram negative whereas Staphylococcus Aureus (7.8%) and Enterococcus spp. (5.8%) in gram positive organisms. Antibiotic susceptibility pattern of these isolates revealed that Amikacin susceptibility in gram negative isolates was more than 40% except for Pseudomonas spp. Co-trimoxazole, Augmentin and quinolones were not found to be effective. In MDR strains cefotaxime + sulbactam, imipenem and meropenem were effective. In Pseudomonas spp. Piperacillin , ceftazidime and Amikacin and piperacillin + Tazobactam (MDR Strains) were effective. Methicillin resistance was reported in 33.8% cases Maximum susceptibility was seen to Amikacin, Nitrofurantoin and cefotaxime. All MRSA isolates showed 100% susceptibility to vancomycin. No Vancomycin resistant enterococcus were encountered in the study.


Previous studies have indicated the potential for emissions of volatile organic compounds (VOCs) from industrial and municipal sewers. However, existing estimation methods can significantly overestimate emissions of VOCs over a wide range of sewer operating conditions. This paper reviews three methods for estimating emissions from sewer reaches: equilibrium, open trench, and cocurrent ventilation. A new methodology is presented that combines both equilibrium and open‐trench approaches. The maximum error associated with this combined model is shown mathematically to be 58% and independent of flow and reach characteristics.


In investigative interviews concerned with allegations of sexual abuse, open-ended prompts by interviewers elicit more information than focused prompts. We attempted to explore these effects in investigations of physical abuse. Interviews with 50 children from 2 age groups (5–6-year-olds, 9–10-year-olds) who made subsequently substantiated allegations of physical abuse by their parents were subjected to detailed psycholinguistic analysis. The overall productivity (number of words spoken) and informativeness (number of details elicited) of these children were remarkably low. The children were also relatively unresponsive to the investigators' individual utterances, and many of the interviewers' utterances were nonsubstantive (15%). The interviewers were more likely than those included in studies of sexual abuse investigations to use open-ended as opposed to focused prompts. These open-ended utterances elicited significantly more words but not more details than focused prompts. Older children also provided ...


A fixing structure for an electronic card is suitable for mounting a long electronic card or a short electronic card within a housing. The fixing structure includes a pressing plate, a locking slice, and a locking member. Two ends of the pressing plate have two buckling portions. The locking slice connects an end of the pressing plate and has a locking hole. Besides, the locking slice leans against the housing. The locking member passes through the locking hole and is fixed into a first fixing hole or a second fixing hole. When the locking hole corresponds to the first fixing hole, the two buckling portions are fixed onto a free end of the long electronic card. When the locking hole is corresponding to the second fixing hole, the two buckling portions are fixed onto a free end of the short electronic card.


The utility model discloses a moving device for radiation therapy, which comprises a bearing plate body, a supporting plate body, a lifting device, a chassis and a fixing device, wherein the fixing device installed on the bearing plate body can fix a trunk and limbs of a patient conveniently, and can effectively prevent bad treatment effect due to position changes of the patient, the lifting device arranged on the bottom of the bearing plate body can change the height of the bearing plate body on the vertical surface and is convenient for moving the patient, a handle which is further arranged on the bearing plate body can be used to move the patient conveniently, a rope also can be installed on a wall of a treatment room, the patient can be stably moved to the treatment position through utilizing the rope and the handle which are matched, the pain of the patient can be reduced, and the labor intensity of doctors also can be reduced simultaneously.


Injury to the kidneys can lead to acute kidney injury (AKI) and chronic kidney diseases (CKD).2 When the kidney injury is mild or acute (AKI) occurs, tissue repair mechanisms can usually restore kidney function. However, suppose the repair mechanism is compromised or the stimulus causing injury remains. In that case, AKI can develop into a chronic disorder (CKD), a condition characterized by organ remodeling and fibrosis.3 Fibrosis is a feature typical of CKD.2 Fibrosis is also closely associated with failed manifestations; fibrosis is associated with a poor long-term prognosis.4


Abstract Reactive extrusion printing (REP) is demonstrated as an approach to simultaneously crystallize and deposit films of the metal–organic framework (MOF) Cu3btc2 (btc=1,3,5‐benzenetricarboxylate), also known as HKUST‐1. The technique co‐delivers inks of the copper(II) acetate and H3btc starting materials directly on‐surface and on‐location for rapid nucleation into films at room temperature. The films were analyzed using PXRD, profilometry, SEM and thermal analysis techniques and confirmed high‐quality Cu3btc2 films are produced in low‐dispersity interconnected nanoparticulate form. The porosity was examined using gas adsorption which showed REP gives Cu3btc2 films with open interconnected pore structures, demonstrating the method bestows features that traditional synthesis does not. REP is a technique that opens the field to time‐efficient large‐scale fabrication of MOF interfaces and should find use in a wide variety of coating application settings.


Damage to the heating surfaces of waste heat boilers in dry coke cooling (DCC) installations constitutes a serious danger. Damage can arise from numerous causes, including tube overloading and thermal aging, fluctuating thermal loads, tube corrosion (internal and external), tube erosion and abrasive wear, and failure to observe correct water condtions. The presence of coke dust in the circulating gases leads to the build-up of loose dirt deposits on the heating surfaces. The further consequences include lower heat transfer rates, local tube overheating and thermal stressing. When the thermal loads are constantly fluctuating, expansion and contraction stresses give rise to thermal fatigue and eventual metal failure. Many steam boiler components are subjected to repeated heating and cooling cycles, which lead to thermal fatigue. Moreover, prolonged exposure to high temperatures produces microstructural changes in the steel and may lead to embrittlement at the working temperature. The circulating gases contain oxygen, carbon dioxide and water vapor, which corrode the outer tube surfaces; the inner tube surfaces are similarly attacked by the steam. Thus boiler components are attacked from numerous directions by factors which all operate simultaneously. In these circumstances, it is both very important and very difficult to prevent or even reducemore » damage to the heating surfaces. They can only be effectively protected by adopting a set of precautions which can include, for example: Removing coke dust from the circulating gases; stabilizing the thermal load on the boiler; stabilizing the water conditions; and cleaning the heating surfaces.« less


In the era of " Internet plus",travel websites play an increasingly important role in the tourism industry. Based on the current status analysis,according to the value chain theory,operation mode of the Tencent Fujian Travel Channel is investigated from the four independent links of clients,brands,products,and market. It is proposed to develop the mobile APP,balance regional distribution of the clients,and obtain revenues from advertisement,products and service.


Submitted for the DAMOP11 Meeting of The American Physical Society Non-Equilibrium Resonant Dynamics of Ultra-Cold Bosons in the Strongly Correlated Regime CHESTER RUBBO, University of Colorado/JILA, SALVATORE MANMANA, JILA, ANA REY, REY GROUP TEAM — We study the static and dynamical properties of strongly interacting ultra-cold bosonic atoms loaded into a 1-D optical lattice with an external linear potential in light of recent experiments performed by the Greiner group at Harvard. Onsite strong interactions generally suppress motion, but when the external field is tuned resonantly with the interaction parameter, nearest neighbor tunneling is restored. The dynamics can be explained by mapping the system to states of dipole configurations. We obtain an exact understanding of the dynamics in few-body systems and use it to describe the many-body dynamics at low fillings. We test the validity of our model by comparisons to DMRG calculations. We also propose a controllable scheme to enhance mass transport. Finally, we extend the same study to systems exhibiting longer-range interactions. Chester Rubbo University of Colorado/Jila Date submitted: 03 Feb 2011 Electronic form version 1.4


Astroparticle physicists in Europe have identified the top seven experimental facilities to build over the next 10 years. The projects, which are outlined in a new road-map drawn up by the ASPERA consortium of funding agencies, are currently at the design stage and would cost up to €1.5bn to build.


Abstract The aim of this study was to investigate the CYP1B1 and MYOC genes in patients with primary congenital glaucoma (PCG) from the Cukurova region (located in the south of Türkiye) and reveal the relationship between gene mutations and clinical severity of the disease. Molecular genetic and clinical study was conducted in 42 eyes of 26 patients who were followed for a diagnosis of PCG. The clinical diagnosis was concluded by ophthalmological examination under general anesthesia or slit-lamp biomicroscopy, gonioscopy, and measurement of the intraocular pressure. A CYP1B1 gene mutation was detected in 12 patients (46.2%). Two of these patients had a combination of CYP1B1 and MYOC mutations. The most common pathogenic variant, c.1405C > T (p.R469W) ( n  = 5), was present in patients with mutations, and the prognosis was poor compared with other modifications ( p  = 0.014). The second most common variant was c.3987G > A (p.G61E) ( n  = 3), which was associated with a good prognosis. The incidence of buphthalmos and the mean horizontal corneal diameter were higher in patients with mutations in the CYP1B1 and MYOC genes. All parents were found to be carriers of the mutation gene. This is the report on molecular genetic analysis of PCG in the southern region of Türkiye. Some specific genetic variants may have an effect on the prognosis of the disease. However, patients without mutations in these case groups may have mutations in genes yet to be identified.


US public health experts are working with law enforcement, intelligence, and defence agencies to make contingency plans for dealing with a bioterrorist attack.

Federal health officials at the US Centers for Disease Control and Prevention (CDC) have said that public health departments, on a local and state level, should be given the chief responsibility for responding in the event of any bioterrorist incident.

In a statement entitled Bioterrorism Preparedness and …


The article analyzes the current state of filling the special budget of the budget with state educational institutions, examines the financial instruments for diversifying the sources of own revenues of state institutions of higher education. The experience of foreign universities in the areas of financing optimization in order to ensure their financial autonomy is considered. A number of measures have been proposed to expand the range of sources of income for Ukrainian universities.


BACKGROUND: Stroke is a major Non-Communicable Disease which is responsible for 3.5% of Disability Adjusted Life Year (DALY) in India. Post-stroke shoulder pain is a most common impairment affecting patient's participation in rehabilitation by sensory motor impairment and limitation of daily living activity in chronic stroke patient.
OBJECTIVE: Numerous theories exist to explain the patho-mechanics behind development of Post-stroke shoulder pain, but its relationship with the sensory-motor function of the affected limb is needed to more elaborate. So it is important to study the prevalence of Post-stroke shoulder pain (PSSP) and its association with different factors with post stroke shoulder pain (PSSP).
METHDOLOGY: Visual Analogue Scale was used to measure shoulder pain and Passive Range of Motion of shoulder joint was assessed by using a goniometer. Motor functions was assessed by using the upper limb subscale of the Motor Assessment Scale (UL-MAS), Somatosensory impairment of the upper extremity was assessed by Erasmus MC modifications to the(revised) Nottingham Sensory Assessment scale (EmNSA) and Activity of Daily Living impairment was assessed by Modified Barthel Index (MBI). Scores were examined and compared between the shoulder pain group (SPG) and the No Shoulder Pain Group (No-SPG).
CONCLUSION: Results from this study shows post stroke shoulder pain is associated with reduced upper extremity sensory motor functions, ADL and passive range of motion of shoulder joint. This emphasizes that prevention of shoulder pain will help in regaining upper extremity sensory motor functions, reduced range of motion of shoulder joint and ADL.

Key words: [Post-stroke shoulder pain, activity of daily living, Somatosensory impairment, upper arm motor function.]


The present invention relates to a modularized forwards-folding type fin stabilizer executing mechanism which mainly solves the technical problems of improving the operating performance of the executing mechanism, reducing the manufacturing and assembling cost, etc. The technical proposal is that: the mechanism is provided with a fin box; the fin box consists of an upper plate, a lower plate, a front upper plate, a front lower plate, shear strakes and side plates which are combined as a whole. The box is provided with a fin box opening. The inner cavity of the fin box is an inner watertight cavity. The lower plate and the front lower plate of the fin box are respectively connected with corresponding components of a hull in a fixed way. The side plates are provided with retractable link stoppers which are corresponding to a lug boss of a crosshead component. The modularized forwards-folding type fin stabilizer executing mechanism is fit for various forwards-folding type fin stabilizer devices.


In this brief, a direct synthesis method is proposed to extract the coupling matrix of multi-port filtering power divider (FPD) for mixed topology for the first time. Different from the existing cross-coupled configuration, extracted pole based topology containing non-resonating nodes (NRN) is introduced into the multi-port FPD network to eliminate some inherent limitations. All the elements of coupling matrix are obtained directly in the synthesis process by optimizing the cost function with the deigned Quantum Particle Swarm Optimization (QPSO) algorithm in this brief, avoiding evaluating the numerical value one by one from the conventional two-port filter synthesis method and eliminating the step of similarity transformations of the coupling matrix. Moreover, impedance matching has been considered to the FPD synthesis process to meet the comprehensive needs of more scenarios. Several numerical examples of FPD with equal/unequal power division ratios and arbitrary reference impedance, different responses for both symmetrical and asymmetrical mixed topologies are synthesized to verify the proposed synthesis method.


The interpretation of cosmological observations relies on a notion of average Universe, which is usually taken as the homogeneous and isotropic Friedmann-Lema\^itre-Robertson-Walker (FLRW) model. However, inhomogeneities may statistically bias the observational averages with respect to FLRW, notably for distance measurements, due to a number of effects such as gravitational lensing and redshift perturbations. In this article, we review the main known theoretical results on average distance measures in cosmology, based on second-order perturbation theory, and fill some of their gaps. We then comprehensively test these theoretical predictions against ray tracing in a high-resolution dark-matter $N$-body simulation. This method allows us to describe the effect of small-scale inhomogeneities deep into the non-linear regime of structure formation, on light propagation up to $z=10$. We find that numerical results are in remarkably good agreement with theoretical predictions, in the limit of super-sample variance. No unexpectedly large bias originates from the very small scales, whose effect is fully encoded in the non-linear power spectrum. Specifically, the directional average of the inverse amplification and the source-averaged amplification are compatible with unity; the change in area of surfaces of constant cosmic time is compatible with zero; the biases on other distance measures, which can reach $\sim 10^{-3}$ at high redshift, are well understood. As a side product, we also confront the predictions of the recent finite-beam formalism with numerical data, and find excellent agreement.


Aiming at the problems of secondary pollution and resource waste caused by inaccurate input of coal and ammonia in coal‐fired power plant, an optimal controlling method of combustion and denitration coordinated operation based on Deep Deterministic Policy Gradient (DDPG) is proposed in this paper. First, the environmental model is constructed by the Stacking algorithm to predict the NOx emission concentration of the combustion and denitration system, which provides environmental state feedback for the optimal controlling model. Second, the optimization controlling model is constructed based on the DDPG algorithm within the standard limitation of denitration efficiency and NOx emission concentration. This model takes the minimization of comprehensive cost as its optimization objective to realize the optimal control of controllable variables in the cooperative operation process of combustion and denitration. The experimental results of real operational data from 1000 MW boiler unit in a power plant locating in south China show that the optimization results of coordinated operation for the combustion and denitration system are better than single‐stage optimization results. In addition, the total cost is reduced by 1%–3% on average compared with before optimization.


The present invention relates to a moving body positioning art, using RFID to provide a moving object in real time position determination system and method to pinpoint the location of a moving object in real time. To this end, the present invention relates to a mobile positioning system, but communicates with the RFID tag being installed / attached to the position recognition target object including a radio relay apparatus for identifying the RFID tag, by installing the radio repeater in urban infrastructure facilities , and the position coordinates of the showing-based facility in the wireless relay device as a reference point (position coordinate information) is characterized in that for determining the position of the location-aware object. Moving object, position, location, RFID, insulation triangle, reader, tag, street lights


Sir: Irumamycin (1)'), a 20-membered ring macrolide antibiotic active against phytopathogenic fungi, is produced by Streptomyces subflavus subsp. irumaensis AM-3603. The previous biosynthetic studies of irumamycin2 showed the incorporation of 13C-labeled acetate and propionate into the aglycone of irumamycin. In order to elucidate the biosynthetic pathway to irumamycin after the formation of aglycone, mutants blocked in the biosynthesis of the antibiotic were generated by the treatment of the irumamycin-producing strain S. subflavus subsp. irumaensis AM-3603 with N-methyl-N'-nitro-N-nitrosoguanidine. A mutant, strain FN-114, was obtained which produced a mixture of two new 20membered lactones named irumanolides I (2) and 11 (3). This paper describes the fermentation, isolation and characterization of the two compounds. The lactone complex was produced in a 30-liter jar fermentor containing 20 liters of a medium consisting of 2 % glycerol, 0.4%, glucose, 1% soybean meal and 0.3 % NaCl (pH 7.0 prior to sterilization). After inoculation, the culture was incubated at 27°C with agitation (250 rpm) and aeration (10 liters/minute) for 67 hours. The harvested fermentation broth (15 liters) was extracted with ethyl acetate. After evaporation of the extract,the residue was washed with nhexane, and subjected to column chromatography on silica gel with benzene acetone (5: 1) as development solvent. The fractions giving a single spot on silica gel TLC were collected and concentrated to give 0.75 g of 2 and 1.75 g of 3 as white amorphous powders. Physicochemical properties of 2 and 3 are listed in Table 1. The molecular formula of 2 was determined to be C34H54O7 by high resolution mass spectrometry; observed, molecular ion m/z 574.385; calcd. m/z 574.386. The molecular formula of 3 was shown to be C34H56O8; observed, molecular ion mlz 592.398; calcd. mlz 592. 397. Elemental analyses and mass spectra of 2 and 3 suggest the absence of 3-O-carbamoyl-2deoxyrhamnosyl moiety present in irumamycin molecule. The structures of 2 and 3 were deTable 1. Physicochemical properties of irumanolides I (2) and 11 (3).


The implantation of transvenous devices in patients who underwent tricuspid valve replacement represents problems, especially if an epicardial position is not available. The implantation of a "pace-sense" lead via the coronary sinus is a safe and feasible procedure. For experienced surgeons in implantation of biventricular devices, the implantation of leads via the coronary sinus is a routine procedure. Bipolar leads are essential for the correct sensing and pacing of the implantable cardioverter-defibrillator (ICD). In patients who underwent tricuspid valve replacement who have the indication of an ICD implantation postoperatively, the combination of a shock electrode placed in the superior vena cava, a subcutaneous array positioned on the left posterior close to the spine and an active can, placed subpectorally in the left infraclavicular region, is an alternative solution.


Simulating fluid behavior has proven to be a demanding challenge which requires complex computational models and highly efficient data structures. Smoothed Particle Hydrodynamics (SPH) is a particl ...


Despite the extreme conditions of temperature (down to 10K) and density (down to 100 molecules/cm3), the giant molecular clouds and the circumstellar envelopes present a rich and complex chemistry. To date, more than 180 molecules have been detected in the InterStellar Medium (ISM) with a large abundance of nitriles (RC≡N). In addition, several anions have been recently observed in this medium: C4H¯, C6H¯, C8H¯, CN¯, C3N¯ and C5N¯. These last species should play a key role in the molecular growth towards complexity. To explore this hypothesis, their reactivity must be studied in the laboratory. The FALP-MS and the CRESU experimental apparatuses of the Rennes University are able to measure absolute rate coefficient of various chemical reactions, including the ion – molecule reactions, in gas phase at low temperature (from 300K for the FALP-MS down to 15K for the CRESU). Therefore, these experimental tools are particularly adapted to the kinetic studies of reactions potentially involved in the Interstellar ...


A chaotic synchronized secure communication method based on time-varying parameter is presented. The method improves security performance of communication greatly, and can defeat all kinds of attacking methods at present. The parameter sensitivity of chaotic synchronization makes chaotic synchronization robust, but eavesdroppers can follow this way to attack and defeat communication system. Time-varying parameter method can solve this problem. In simulations, based on Chua circuit to communicate, the time-varying parameter method defeated the attacking of all kinds of breaking methods at present. The high security performance of this method is confirmed by these simulations


Integrated energy systems is an effective way to achieve carbon neutrality by improving the utilization of renewable energy through the synergistic complementation of multiple energy sources. At present, hard clustering algorithm such as K-means clustering is usually used for clustering in the probabilistic flow calculation of power system, but they will bring some error in the multi-energy coupling scenarios with multiple uncertain variables. Therefore, in this paper, we consider the uncertainty of renewable energy and multiple energy loads to model and apply the fuzzy C-means clustering algorithm in probabilistic energy flow calculation for the integrated energy systems of electricity, heat and gas. First, establish a hybrid energy flow model of the integrated energy systems considering the uncertainty and relevance of renewable energy and multiple energy loads. Then the cumulant method is used to solve the probabilistic energy flow and the fuzzy C-means clustering algorithm is used to cluster the scenarios and reduce the linearization error. Finally, the simulation analysis of the actual case shows the accuracy of the probabilistic energy flow calculation applying the fuzzy C-means clustering algorithm.


We must build the implementation of culture,in order to enhance the implementation of public policy.The implementation of the system must be improved,the value orientation of the correct guidance,and establishing and improving balance of interests of various mechanisms,improving the mechanism of selecting and appointing cadres,creating a good environment of law,enhance the sense of responsibility in organizational culture.


A semiconductor manufacturing apparatus comprising: a support unit for supporting a semiconductor wafer received from the CMP apparatus; and a vacuum system for holding the wafer on the support means. The vacuum is applied only in the peripheral area of the wafer. In the peripheral region of the wafer, for example, without producing any circuit interconnect and the device. When provided by a gas released into the vacuum space of the wafer by static electricity which occurs only in the absence of any peripheral circuit area, even if the presence of static electricity, an electronic circuit fabricated on the wafer it will not be damaged.


Soil characteristics and geomorphology were investigated in an area designated Glacial Lake Douglas, in Douglas County in east-central Illinois. The study area was once covered by a glacial lake, with a surface elevation of approximately 650 feet, which occupied a broad, shallow depression in the Wisconsinan till plain. Beneath the solum there were clayey, silty, and sandy sediments which had been deposited in a lacustrine environment, and glacial till. X-ray analyses indicated that the solum was mainly of loessial origin, while the lacustrine sediments were outwash materials from the glaciers which deposited the nearby Wisconsinan till. The lakebed sediments were thickest southwest of the Embarras River and became thinner northeast toward Newman. Laminated, clayey sediment was absent in a wide area west-southwest of Camargo, probably because this was a delta when glacial meltwaters filled the lake. Elevation of the top of the clayey sediment was lowest close to the main drainage outlet, and it became higher in an outward-radiating pattern until it reached an average maximum elevation of $$639.5 \pm 2.3$$ feet at its outer margin. Total drift thickness over bedrock ranged from approximately 15 to 20 feet over some bedrock uplands near Newman to about 200 feet over parts of the Pesotum bedrock valley. Drainage of Glacial Lake Douglas marked the first time that Embarras River extended this far north. There is a close relationship between the occurrence of the clayey, lacustrine sediment and the principal, poorly drained, dark soil in Glacial Lake Douglas. This lakebed soil has higher clay and sand content, lower silt content, higher bulk density, lower organic carbon levels, and lighter colored Ap and $$A_{1}$$ horizons than Drummer silty clay loam, a poorly drained, dark soil that occurs extensively in areas around Glacial Lake Douglas.


LetDbe a set with a probability measure?,?(D)=1, and letKbe a compact subset ofLq(D, ?), 1?q<∞. Forf?Lq,n=1, 2, ?, let?n(f, K)=inf?f?gn?q, where the infimum is taken over allgnof the formgn=?ni=1ai?i, with arbitrary?i?Kandai?R. It is shown that forformula], under some mild restrictions,?n(f, K)?Cq?n(K)n?1/2, where?n(K)?0 asn?∞. This fact is used to estimate the errors of certain neural net approximations. For the latter, also the lower estimates of errors are given.


Introduction 1. Reforms within the Judiciary 2.National and International Dialogues 3. Political Participation and Municipal Elections 4. Political Reforms and the Succession Dilemma 5. Reforms and the Petition Industry 6. Saudi Arabia and the United States 7. Conclusion


Betaseron (beta ser17-interferon) was administered to 19 patients (17 evaluable) with advanced melanoma by two schedules. Patients received either 30 X 10(6) units (mU) by intravenous bolus 5 days a week for 2 weeks followed by 2 weeks rest, or 30 mU daily for 5 days in week 1, 60 mU daily for 5 days in week 2, then twice-weekly doses escalating from 90 to 270 mU. Toxicity commonly included malaise, fatigue, fever, and weight loss. Mild hematologic, gastrointestinal, and hepatic toxicity were also seen, as well as an episode of atrial fibrillation in a patient with mitral valvular disease. No responses to therapy occurred.


The object of this investigation was evaluate the effect of breed group and some non-genetic factors on farrowing interval (IEP) in Duroc (D), Hampshire (H) sows and their reciprocal crosses. A total of 4 008 records from a genetic center pig located in the Yaracuy state, were analyzed. An analysis of variance with unequal number of observations using the restricted maximum likelihood procedure


AIM
In many case reports the success of treatment of late complications of radiotherapy with hyperbaric oxygenation (HBO) has been shown. This synopsis attempts to review HBO in the treatment of chronic radiation injury of the bladder.

PATIENTS AND METHODS
Three female patients who had developed urge-incontinence after a Wertheim operation and combined brachy-teletherapy with cobalt-60 and afterloading and did not respond to various drug therapies, were treated with HBO to a maximum of 40 applications.

RESULTS
In all patients HBO altered and inverted the dynamic process underlying chronic bladder changes after irradiation. Rationales for the HBO are the reduction of tissue hypoxia and the induction of neoangiogenesis.

CONCLUSIONS
There are no prospective trials up to date showing the benefit of HBO to urinary disorders caused by radiation cystitis. The positive results of our retrospective study should encourage clinicians to initiate prospective studies with the use of HBO in the treatment of radiation cystitis.


In several countries, totalitarianism, fascism and national-socialism had racial topics as core policies. Other countries did not necessarily have a liberal thinking on this specific matter, and also approved discriminatory laws. In Latin America, eugenics had a great impact on public health policies during the first half of the 20th century, and gave rise to stigmatization of ill persons and of different races. Ninety years after its publication, a doctoral thesis on the race in Antioquia, Colombia, may still have validity.


The problem of the radiation of an oscillating dipole, moving at a constant velocity in a magnetized plasma, is examined. The temporal and angular structure of the signal, received by a stationary tracking antenna, are analyzed


ABSTRACT Sorghum cultivar development in semi-arid Tanzania has understated the importance of heterogeneity in the farm environment. A new approach, combining farmer knowledge and on-farm involvement with field-station and controlled-environment quantification of sorghum growth, has provided baseline data on the response of cultivars to parasitic Striga species when different soil resources are available. Involving farmers and creating recommendations for the local use of the different cultivars represents a step towards empowering farmers to make informed choices in the selection of appropriate sorghums for diverse situations. INTRODUCTION Agricultural soils in semi-arid Tanzania are generally of low to moderate fertility. Low nitrogen (N) conditions favour the growth of witchweeds ( Striga spp.: Scrophulariaceae); root hemiparasites devastating to yields of cereal crops. Farmers recognise local soil types based on criteria including suitability for different crops, ease of cultivation, moisture retention and drainage (Lamboll


• R is reflexive if for all a ∈ A, 〈a, a〉 ∈ R. • R is irreflexive if for all a ∈ A, 〈a, a〉 6∈ R. • R is symmetric if for all a, b ∈ A, 〈a, b〉 ∈ R implies 〈b, a〉 ∈ R. • R is antisymmetric if for all a, b ∈ A, 〈a, b〉 ∈ R and 〈b, a〉 ∈ R implies that a = b. • R is transitive if for all a, b, c ∈ A, if 〈a, b〉 ∈ R and 〈b, c〉 ∈ R, then 〈a, c〉 ∈ R. • R is total if for all a, b ∈ A, either 〈a, b〉 ∈ R or 〈b, a〉 ∈ R.


Current vocal output generation systems lack portability and variability. Text-to-speech synthesis is not well accepted by users for its lack of conviviality. We propose alternative approaches to generating spoken utterances that fulfill the quality requirements of a speech output system. Our framework for language generation relies on conceptual segments, we controlled their acoustic realization by means of four basic methods based on four levels of representation: signal concatenation, text-to-speech, mimicking synthesis and phonological prosodic command driving the speech synthesizer. Examples produced allow a step towards flexible and contextually appropriate generation of spoken utterances.


Background: 50-75% of all the patients who are on dialysis suffer from significant xerosis. But the exact cause is difficult to trace. Acquired ichthyosis is seen in some patients. Atrophy of sebaceous glands is seen in patients with uraemia. Such patients also show overall decrease in sweet volume. Objective was to study the clinical profile of patients with cutaneous disorders. Methods: A hospital based prospective study was carried out from September 2012 to February 2013 at a tertiary care centre of Late Baliram Kashyap memorial government medical college, Jagdalpur, Chhattisgarh, India. A total of 50 patients with cutaneous disorders were studied with respect to their clinical profile. Patients not willing to participate in the present study as per the protocol were excluded from the study. But patients giving their willingness to participate in the present study as per the protocol of the study were included in the study. Results: The males constituted 58% of the total cases and the females constituted 42% of the total cases. Maximum patients were seen in the fourth and fifth decade of their life i.e. 24% followed by the age group of 31-40 years i.e. 22%. The most common cutaneous manifestation was pruritus in 24% of cases followed by xerosis in 16% of cases. Next most common cutaneous manifestation was Tinea versicolor inn 14% of cases followed by oral candidiasis in 8% of cases and scabies were seen in 6% of cases. Both among males and females, pruritus was the most common skin lesion seen. Conclusions: The most common cutaneous lesion found in the present study was pruritus in 24% of cases followed by xerosis (16%), Tinea versicolor (14%), oral candidiasis (8%) and scabies in 6% of cases. Cases of nail changes, herpes zoster, Tinea cruris, hyper pigmentation, folliculitis, Exfoliative dermatitis, and Kyrle's disease, Vitiligo, Melisma and Keloid were also seems.


This paper presents a novel speed control approach for inverter-fed three-phase (3Phi) induction motors. The proposed approach is called the resolution-level controller (RLC) that is realized for the 3Phi voltage-source (VS) wavelet-modulated (WM) inverters. The wavelet modulation technique generates switching pulses using a non-dyadic type multiresolution analysis (MRA) that is constructed by three scale-based linearly-combined scaling functions shifted by 2pi/3 from each other. Moreover, The change in the scale of the three synthesis scaling functions is based on the change of the sign of the first derivative of the reference-modulating signals. The three scaling functions have dual synthesis scaling functions that are responsible for reconstructing the three continuous-time reference-modulating signals from their nonuniform recurrent samples. The reconstruction processes are carried out by the three synthesis scaling functions to achieve 180-degrees conduction mode of the 3Phi inverter. The proposed RLC approach is based on adjusting the zero-crossing locations of the first derivative of the reference-modulating signals to change scales of successive dilated and shifted versions of the three synthesis scaling functions. This change in scales can be incorporated to adjust the speed of the induction motor to meet load changes. The complete drive incorporating the RLC is successfully implemented in real-time using a digital signal processor board dSPACE ds1102 DSP board to generate switching pulses to activate the inverter six IGBT switches. The IGBT inverter supplies a 1 hp, 1750 RPM, 208 V, 60 Hz, Y-connected 3Phi squirrel-cage induction motor that is tested for several speed and load variations. The test results demonstrate robust performance, simple implementation, significant dynamic responses and high ability to maintain high quality outputs.


Edited by Peter G. Neumann (Risks Forum Moderator and Chairman of the ACM Committee on Computers and Public Policy), plus personal contributions as indicated. Opinions expressed are individual rather than organizational, and all of tile usual disclaimers apply. Please send RISKS-related items only to Peter G. Neumann, SRI International EL-243, 333 Ravenswood Ave., Menlo Park CA 94025-3493 (1-415859-2375; firstname.lastname@example.com).


A reshuffle in the cabinet, after the death of the Minister of Public Works, led to the appointment of Land Affairs Minister Thoko Didiza as the new Minister of Public Works. The former Deputy Minister of Minerals and Energy, Lulu Xingwana, was appointed the new Minister of Land Affairs and Agriculture (Mulder 'Agri SA "jammer dat Didiza gaan"' Die Burger (2006-05-23) 5); De Lange and Mulder 'Nuwe landbou-minister dikwels in die sop oor wilde uitlatings' Die Burger (2006-05-23) 5. Agricultural unions are confident that as sound a working relationship as with the previous minister will continue.


The myth "women prioritize socioeconomic status whereas men value physical beauty" is continuously reproduced. The heterosexual online dating literature that addresses image production highlights the dominance of this gendered and heteronormative binary in self-presentations. Examining how heterosexual individuals use dating apps, this study focuses on image consumption and how profiles as the products of this beauty-status binary are perceived. Using video interviews and reenactment techniques to analyze users' practices of swiping, i.e., mate selection, this study also offers a novel research method to the literature. The findings demonstrate how the so-called binary creates a dictatorship of clichés and how individuals affectively, though partially, respond to this visual bombardment by feeling an attraction toward naturality. It underlines that bodies are not simply shaped and controlled by cultural institutions, norms, and laws but also respond to the situations and environments in which they find themselves. This paper invites future studies to focus on what images can do to bodies and how bodies respond to them and break the beauty-status myth rather than expose it.


Kepler wrote a great amount of material on Wallenstein's astrology. Some has been translated into English, and the (German and Latin) interpretations of 1608 and 1625 are now reproduced in their entirety in GW 21, 2.2, pp. 445-470, with calculations on pp. 471-475. In this section we present some of the letters leading up to the 1625 interpretation and excerpts from the interpretation itself. These letters and partial translation of Kepler's 1625 re-evaluation of Wallenstein's astrology in this section complement Kepler's earlier interpretation of 1608, which has been translated into English by Kenneth Negus.


[Objective] Analyse explore the effect of sports training on Heart Rate Variability. [Methods] HRV signals obtained by 512 times domain and frequency domain with MCA-3C. [Results] P50, SD, HF.H and pulse pressure and R-R interval of heart rate increase significantly by P0.05. The sports train decrease significantly heart by P0.05. The sports train increase HRV total power(TP), LF.H, LH.A, HRV parameter LH.S, HF.A, HF.S and LF/HF ratio in differents student show no difference by (P0.05). [Conclusion] It demonstrate that the HRV parameters of time domain have a significant difference between trained students and common students.


This Paper Proposes A System Which Converts American Sign Language Hand Gestures Into Text Cum Speech And Helps To Bridge The Communication Gap Between DeafMute People And Rest Of The Society. Any System For This Purpose Generally Has Four Modules: Segmentation, Feature Extraction, Classification And Text-To-Speech. This Paper Focuses On An Improved Method For The Segmentation And The Feature Extraction Processes To Get More Better Resultswhile Using The Standard Techniques On The Other Two Modules. Proposed Algorithm Captures Initial 30 Frames Of The Live Video From The Web Cam Of The System To Construct The Background Model. It Then Finds The Absolute Difference Between The Current Frame And The Background Model In Order To Get The Foreground. Various Features Are Extracted To Classify The Gestures Like Contour, Convexity Hull Etc.. Proposed Algorithm Has Been Tested Under Low And Normal Room Light Conditions. The Overall Performance Of The Proposed Model Will Be Very High And Will Produce Far More Better Resultsdue To Improved Proposed Algorithms For The Initial Two Modules In Comparison To Other Standard Techniques Used Like Hsv, Ycbcr The Above System Can Be Incorporated Into Simple Web Applications, Mobile Applications And Many Other Applications Translating Gestures In The Conversations In Real Time.


This bachelor thesis deals with the problems of violence in the children's literature. The theoretical part is an insight into this problematics. Individual chapters are divided by ontogenetic periods. Each chapter deals with particular books which contain violence and therefore are not convenient for children of certain age and contrariwise. For each ontogenetic period I have chosen two of the most famous or the most popular children's writers. I have presented the writers and also their work. The practical part focuses on a quantitative research of the most popular children's books. The research is based on a mini questionnaire aimed at children from six to eight years of age. Furthermore, I deal with the qualitative research of a book that I have chosen for this purpose.


: Objective: The purpose of this study was to determine the pattern of clinical presentations, haematological and biochemical abnormalities and outcome of dengue fever patients. Study Design: A descriptive cross-sectional study. Place and Duration of Study: This study was conducted in Department of Medicine, Benazir Bhutto Hospital, Rawalpindi from August, 2018 to July, 2019. Material and Methods: Patients meeting the inclusion criteria were admitted at Benazir Bhutto Hospital Rawalpindi and blood serology was done to confirm the diagnosis of dengue fever. Cases with positive dengue serology were included in the study. Clinical symptoms, signs, investigations and outcome of these patients were recorded on a proforma. Blood samples were taken for analysis. Chest X-Ray and ultrasound abdomen were done on required basis. Results: Out of forty confirmed cases of dengue fever, there were 25 (62.5%) males and 15 (37.5%) females. Mean age was 40 years. There were 39 cases (97.5%) of dengue fever and one case (2.5%) of dengue shock syndrome. There was no case of dengue haemorrhagic syndrome. Maximum cases were seen in the month of September, 2018. The clinical features noted were: headache and myalgias 62.5%, chills and rigors 57.5%, retro-orbital pain 42.5%, vomiting 35.0%, pruritus 27%, skin rash 20%, abdominal pain 20%, diarrhoea 10%, bleeding 2.5%, ascites and pleural effusion 2.5%, and hepatomegaly 15%. The laboratory findings were: leucopenia 85% and thrombocytopenia 92.5%. Serum alanine transaminase (ALT), urea, and creatinine were raised in 30%, 2.5% and 7.5% cases respectively. Mortality was 2.5%. Conclusion: This study showed that patients admitted to Benazir Bhutto hospital had a milder presentation of dengue fever in the year 2018-2019.


The present invention relates to the technical field of differential machining, and especially relates to a differential case extrusion and punching process. First, blanks are forged to be an initial forge piece through forging, when forging is carried out, a groove is formed at the bottom of the middle of a big disc of the forge piece, and a resistance groove for increasing downward flow resistance of metal is formed in an end face of a cylindrical end. Then the groove at the bottom of the big disc is downwardly extruded through a punch, the thickness of the metal between the groove and the resistance groove is reduced to form a wad, the excess metal between the groove and the resistance groove flows towards the periphery and lower portion of the cylindrical end, so that the length of the cylindrical end is prolonged, the diameter of the cylindrical end is increased, and a mold cavity of an extrusion lower die is fully filled. Then the wad is punched by a punching die to form a through hole. Through optimizing the forge piece structure, when the resistance groove is extruded, the metal can flow towards the periphery conveniently, thereby facilitating forming of the cylindrical end. Then the through hole is machined through punching, so that drilling is not required, workload of chambering and boring is reduced, material utilization is increased, and production cost is reduced.


Background and purpose:  Piceatannol is more potent than resveratrol in free radical scavenging in association with antiarrhythmic and cardioprotective activities in ischaemic‐reperfused rat hearts. The present study aimed to investigate the antiarrhythmic efficacy and the underlying ionic mechanisms of piceatannol in rat hearts.


When a head on collision occurs at moderate speed the motorist-if unrestrained-flexes forward; his legs press against the floor, his knees strike the dashboard, and his head hits the windscreen. What happens next depends on the composition of the glass. On impact the monolithic toughened glass windscreen, in common use in Britain, may shatter into multiple polygonal fragments; it then offers little resistance to the head, which ploughs through the windscreen all the way to the lower frame with serious risk of laceration of the face and eyes. When the eye is damaged the typical injuries are corneoscleral perforation, uveal prolapse, and opacification or dislocation of the lens. Even with modern microsurgical techniques the initial damage is often so severe that many of these eyes are permanently blinded or may even have to be enucleated.4 By contrast, high penetration resistance laminated windscreens are composed of two sheets of lightly tempered glass enclosing a plastic interlayer; they offer a cushioning effect to the head and high resistance to penetration, so that eye injury is rare. Other designs of non-splintering passengerretaining windscreens are available which are equally safe. When the motorist is wearing a safety belt the risk to the eye from windscreens, though greatly reduced, is not eliminated.5 In a collision the body cannot move forwards, but the impact may cause a toughened windscreen to shatter and then disintegrate; or the windscreen may be broken by direct external force such as a stone or animal, so that 15-20 lb (7-9 kg) of compressed glass explodes into the vehicle.6 In either case car occupants wearing belts may have their eyes penetrated by flying glass. In similar conditions laminated windscreens crack in a web like fashion but generally remain intact, so that the risk of eye perforation is negligible. Comparative7 and experimental8 studies testify to the superiority of laminated over toughened windscreens from the standpoint of eye safety; but perhaps the most convincing evidence derives from the parallel development of safety glass for windscreens on both sides of the Atlantic. In the United States and Canada laminated windscreens with high resistance to penetration have been used in all vehicles since 1966; the virtual absence of reported ocular injuries in North America contrasts sharply with the frequency of such reports in Europe, where toughened glass windscreens remain in common use. In Britain legislation on seat belts has been followed by a welcome decrease in the number of perforating eye injuries, but even if seat belts were worn universally some motorists would continue to suffer damage to their eyes from toughened glass windscreens. As a profession we should strive to persuade the government to withdraw its opposition to the European Economic Community proposals: the mandatory fitting of non-splintering passenger-retaining windscreens in all new vehicles is now long overdue.


a powerful tool for modeling and studying neurodegenerative diseases, including the devastating and fatal amyotrophic lateral sclerosis (ALS). The success of this model organism in ALS research comes from the availability of tools to manipulate gene/protein expression in a number of desired cell-types, and the subsequent recapitulation of cellular and molecular phenotypic features of the disease. Several Drosophila models have now been developed for studying the roles of ALS-associated genes in disease pathogenesis that allowed us to understand the molecular pathways that lead to motor neuron degeneration 4 erved. sclerosis; OMIM, Online Mendelian Inheritance in Man; SOD1, superoxide dismutase; T, wild type; dSOD1, Drosophila SOD1; hSOD1, human SOD1; BMAA, β-Nin brain 5; VAPB, VAMP (vesicle-associated membrane protein)-associated protein B; perm protein; hVAPB, human VAPB; dVAP, Drosophila VAPB (DVAP33-A); wn syndrome cell adhesion molecule; PtdIns4P, phosphatidylinositol 4-phosphate; AR DNA-binding protein 43; dTDP-43, Drosophila TDP-43; hTDP-43, human TDP-43; HIV, frontotemporal lobar degeneration; TBPH, TAR DNA-binding protein-43 homolog; enhancer promoter; HDAC6, histone deacetylase 6; BRP, bruchpilot; VCP, valosinmyopathy associated with Paget disease of bone and frontotemporal dementia; RNA recognition motif; NLS, nuclear localization signal; FUS/TLS, fused in sarcoma/ export signal; EGFR, epidermal growth factor receptor; MAPK, mitogen-activated protein ferase; CNS, central nervous system; ITPR1, inositol-1,4,5-trisphosphate receptor type 1; syndrome; TAF15, RNA polymerase II, TATA box binding protein (TBP)-associated factor, 1; RAN, repeat-associated non-ATG; DPR, dipeptide-repeat protein; roteins; EcR, ecdysteroid receptor; RRM1, RNA recognition motif 1; CAC, cacophony


A so far neglected long-distance (also called one-photon exchange) contribution to the rare semileptonic $B^{\pm}\to (\pi^{\pm},K^{\pm})\ell^+\ell^-$ ($\ell=e,\,\mu$) transitions is evaluated. Although it does not contribute to solve the possible breaking of lepton-universality observed by LHCb in the $B^{\pm}\to K^{\pm}(\mu^+\mu^-/e^+e^-)$ ratio, nor provides an important hadronic contamination to their decay rates, its contribution to the branching ratios of the $B^{\pm}\to \pi^{\pm}\ell^+\ell^-$ transitions turns out to be significant. This hadronic pollution should be taken into account when looking for new physics effects in decays into pions, which suggests to restrict these searches to squared lepton-pair invariant mass in the $(1,8)$ GeV$^2$ range. The interference of the one-photon exchange contribution with the dominant short-distance one-loop amplitude induces a sizable CP asymmetry in these rare decays, which calls for dedicated measurements.


Automatically generated detailed transcriptions should be helpful for transcribers annotating speech databases with detailed transcriptions. In this paper, a method for creating detailed transcriptions using a digitised speech signal, word boundary annotation, canonical transcriptions and näıve pronunciation rules is described. Some initial results using word boundaries from an automatic alignment system are presented. Although this data has been based on partly erroneous alignments, the results seem plausible. The system will be developed so that it can use manually annotated word boundaries for forced alignment of canonical transcriptions. This will probably enhance system performance considerably.


Most theories of economic decision-making under uncertainty recognize that the value assigned to an uncertain prospect may differ from its "actuarial value," or that the utility of an expectation may differ from the expectation of the utility. One way of formalizing this idea is to assume that the utility of a prospect is given by a function f(E, V), where E - the mathematical expectation of the gain, V - the variance of the gain. Various considerations about existence and possible shape of such function f(E, V) are presented.


This paper discusses the principle and parameter selecting method of using alternating current magnetic flux changing method to measure relative replacement,presents general procedure for experiment,and conducts corresponding analysis on the parameter selection of components.According to the requirements of experiment for sensitivity,this paper makes a deduction for the condition for maximum value of sensitivity and verifies it by experiment.It can be found in the discussions of experiment theories that this experiment is a relatively good comprehensive experiment,which connects electromagnetic measurement and mechanical measurement,and proves to be good case for transforming measurement..


Families living in poverty face barriers that threaten their fundamental life-sustaining needs. The crisis-of-the-moment (eg, hunger, shelter) can take immediate precedence over education, environmental conditions, and preventive health care. Maslow's hierarchy of needs suggests that socioeconomic groups differ in how they prioritize their daily needs, including healthful food choices (1). The socioeconomic conditions in which families live may pose barriers to achieving favorable health outcomes. Social determinants of health are "conditions in the environments in which people are born, live, learn, work, play, worship, and age that affect a wide range of health, functioning, and quality-of-life outcomes and risks" (2). Communities must assess these complex and interconnected determinants of health to identify root causes of health problems. Cross-sector collaborations are necessary for assessing these determinants and building healthier communities to support children and families (3).


We show that the sonic-point beat-frequency (SPBF) model of the pair of kilohertz quasi-periodic oscillations (QPOs) observed in neutron star X-ray binary systems predicts that the frequency separation Δν between them is usually not exactly equal to the spin frequency νs of the star. Although the stellar spin interacts with the orbital motion of the accreting gas at the sonic radius with a frequency equal to sonic-point beat frequency, the X-ray oscillations are produced by interaction of the gas with the surface of the star, and their frequencies are therefore affected by the flow of the gas from the sonic radius to the stellar surface. For prograde disk flow near the star, Δν is comparable to but usually less than νs, consistent with the observed values of Δν and the values of νs inferred from oscillations during X-ray bursts. We show that the SPBF model also explains naturally the decrease in Δν with increasing QPO frequencies seen in some sources and the plateau in the QPO frequency-X-ray flux correlation observed in 4U 1820-30. The model fits well the QPO frequency behavior observed in Sco X-1, 4U 1608-52, 4U 1728-34, and 4U 1820-30 (χ2/degrees of freedom = 0.4-2.1, not including systematic errors), giving masses ranging from 1.59 to 2.0 M☉ and spin rates ranging from 279 to 364 Hz. Previous work on the model has shown that it naturally explains many other properties of the kilohertz QPOs. These include the existence of just two principal kilohertz QPOs in a given source, the approximate commensurability of the burst oscillation frequency and Δν, and the high frequencies, coherence, and amplitudes of these QPOs. In the SPBF model, the existence of kilohertz QPOs is an effect of strong-field general relativity. Thus, if the model is validated, observations of the kilohertz QPOs can be used not only to determine the properties of neutron stars but also to explore quantitatively general relativistic effects in the strong-field regime.


Premature recoating of solvent-based inorganic zinc primers may lead to early failure by delamination of the coating system. A method was developed that determined the degree of cure of these primers by analyzing the amount of unhydrolyzed ethyl silicate in the film. Laboratory and field studies showed that some batches of primers cured much more slowly than expected. Some films remained solvent-sensitive even after 14 days' exposure in a high-humidity atmosphere


We measure the electron density dependence of carrier mobility in ultra-wide bandgap Al0.85Ga0.15N/Al0.7Ga0.3N heterostructures, using only Au/Pt Schottky contact deposition and without the need for Ohmic contacts. With this technique, we measure mobility over a two-dimensional electron gas density range from 1010 to 1013 cm−2 at an AlGaN/AlGaN heterojunction. At room temperature, subthreshold mobility was 4 cm2/Vs and peak mobility 155 cm2/Vs. Peak mobility decreased with temperature as T−0.86 suggesting alloy scattering as the dominant scattering mechanism.


With the large-scale application of multi-core technology, the problem of high power consumption brought by multi-core has attracted more and more attention. Dynamic power management (DPM) is widely used in various computer systems with its dynamic and controllable power management. While DPM only works when the components are in idle state. For this case, combining with the characteristics of multi-core system, this paper proposes a dynamic start-up and shut-down model of CPU core in multi-core system. When system load is below the threshold, the tasks running on the original core are migrated and then shut down the core, and when the system load is higher than the threshold, start the closed core to satisfy requirements of the new task. Finally, we implement our model with Cpufreq subsystem, and experiment results show that our method could reduce system power consumption when the core utilization is low.


We report on the status of the Long-baseline Neutrino Experiment (LBNE) and the physics potential of the LBNE research program. LBNE (Long-Baseline Neutrino Experiment) is an accelerator-based neutrino oscillation experiment. LBNE will produce a muon-neutrino beam using protons from Fermilab's Main Injector and will detect electron-neutrino appearance and muon-neutrino disappearance using a Liquid Argon TPC located at a distance of 1300 km at the Sanford Underground Research Facility in South Dakota. The primary physics motivation of LBNE is to determine the neutrino mass hierarchy, to determine the octant of the neutrino mixing angle q23, to search for CP violation in neutrino oscillation, and ultimately, to precisely measure the size of any CP-violating effect that is discovered. LBNE is envisioned as a phased program with international participation and leadership. The first phase of the experiment is currently in the detailed-design stage which includes engineering design of the neutrino beamline and underground caverns for the far and near detectors.


In this paper, the deadtime control depending on the load of ZVT interleaved bidirectional low voltage DC-DC converter is proposed. The deadtime is obtained by using the time-varying function of capacitor voltage. The validity of proposed deadtime control is verified by simulation results.


Mononitrosyl diiron complexes having either an [FeII·{FeNO}7] or an [FeIII·{FeNO}7] core formulation have been synthesized by methods that rely on redox state-induced differentiation of the diiron starting materials in an otherwise symmetrical dinucleating ligand environment. The synthesis, X-ray structures, Möss-bauer spectroscopy, cyclic voltammetry, and dioxygen reactivity of the [FeIII·{FeNO}7] is described. Nitric oxide is a major component of the immune defense system in macrophages.1 Although the immune system can generate micromolar concentrations of NO, many pathogenic microbes such as T. vaginalis,2E. coli,3,4 and N. meningitidis5,6 reduce NO to N2O by expressing flavodiiron nitric oxide reductases (FNORs).8 Crystallographic studies9–11 of these enzymes reveal active sites (D. gigas)9 comprising two non-heme iron centers in an unsymmetrical coordination environment provided by histidine, glutamate, aspartate, and water-based ligands. The active site binds NO to generate a high-spin {FeNO}7 species with total spin S = 3/2.8,11,12 Although two conflicting mechanisms involving both mono and dinitrosyl diiron intermediate species have been proposed for this chemistry,8,13,14 recent results favor the mononitrosyl.11,15 These reports include formation of a stable mononitrosyl adduct, formed by addition of one equiv of NO per diiron(II) site of both FMN-free10 and FMN-containing flavin diiron proteins.15 Reactions of NO with synthetic non-heme diiron complexes have been known for over 15 years.13,16 The first report of a dinitrosyl compound, [Fe2(N-Et-HPTB)(PhCOO)(NO)2] (BF4)2 (5a),17 where N-Et-HPTB is the anion of N,N,N′,N′′-tetrakis(2-(1-ethylbenzimidazolyl))-2-hydroxy-1,3-diaminopropane, was followed by the study of an analogous compound, [Fe2(BPMP)(OPr)(NO)2](BPh4)2 (5b).18 Compounds 5a17 and 5b18 represent {Fe(NO)}2 species (S = 3/2) and 5b could be reduced by two electrons, leading to formation of N2O. Although formation of an EPR silent [FeIII·{FeNO}7] species was postulated during oxidation of deoxyhemerythrin to the semi-met form by nitrite ion,19 there is no report to date of any synthetic mononitrosyl diiron compound coordinated by an O/Ndonor dinucleating ligand system. Here we describe the synthesis and characterization of the two such compounds in this class and the importance of the iron oxidation state in controlling the nature of the resulting nitrosylated diiron products. *Corresponding email@example.com. Supporting Information X-ray crystallographic data for 3, 4a–4d in CIF format, structural tables, ORTEP diagrams, cyclic voltammetry, Mössbauer, UV-Vis and IR spectroscopic data. This material is available free of charge via the Internet at http://pubs.acs.org. The authors declare no competing financial interests. NIH Public Access Author Manuscript Inorg Chem. Author manuscript; available in PMC 2014 December 02. Published in final edited form as: Inorg Chem. 2013 December 2; 52(23): . doi:10.1021/ic4019508. N IH PA Athor M anscript N IH PA Athor M anscript N IH PA Athor M anscript Compounds 5a and 5b were stable in solution only in the presence of excess NO gas, and formation of mononitrosyl diiron species was never observed.17,18 We discovered, however, that with use of a mixed valent diiron(II,III) compound to be reported in detail else-where, [Fe2(N-Et-HPTB)(PhCOO)(DMF)2](BF4)3 (2),20 addition of one equiv of trityl nitrosothiol (Ph3CSNO) yielded a mixture of two of four crystalline forms of the compound [Fe2(N-EtHPTB)(NO)(OH)(DMF)2](BF4)3, 4c and 4d (Scheme 1). There are slight differences in the core structures of 4c and 4d (Table 1, Fig. S1), but they are otherwise chemically identical. The product was con-taminated with [Fe2(N-Et-HPTB)(PhCOO)](BF4)2 (6),21 as evidenced by Mössbauer spectroscopy (Fig. S2) and by an X-ray structure determination of light yellow crystals (6) found in the product. To avoid these complications, alternative synthetic routes were explored. A reaction system containing [Fe2(N-Et-HPTB)-(PhCOO)](BF4)2 (6)21 and one or two equiv of Ph3CSNO generated a green solution which, upon work-up, afforded only the starting material 6, as determined by IR spectroscopy and X-ray crystallography. This result is consistent with the chemistry of 5a and 5b, from which NO slowly dissociates.17,18 A different diiron(II) starting compound, [Fe2(N-Et-HPTB)(DMF)4](BF4)3 (1),20 was therefore employed. Reaction of one equiv of Ph3CSNO with 1 yielded [Fe2(N-Et-HPTB) (NO)0.6(DMF)3.4](BF4)3 (3) in 66% yield, in which one of the two iron centers contains NO (59.7%) or DMF (40.3%), disordered in the crystal lattice. Compound 3 contains a [FeII{FeNO}7] site and should be regarded as a mixture of ~60% [FeII{FeNO}7] species and ~40% Fe2 species. Reaction of 1 with Ph3CSNO in the presence of the one electron oxidant, (Cp2Fe)(BF4), however, afforded the different mononitrosyl compound, 4a, as greenish-brown crystals in 45% yield. An alternative method, reaction of 1 with NO(BF4), gave 4b in 90% yield. This reaction may proceed by formal one-electron oxidation of 1 to yield a diiron(II,III) species that is rapidly quenched by NO ̇ generated in situ, which adds to the Fe(II) center. The results of these reactions, taken together (Scheme 1), along with the previous report of dinitrosylation that occurs during reaction of diiron(II) compounds with excess NO gas,17,18 clearly establish the crucial role of iron oxidation states within these diiron compounds in determining the nature of the nitrosylated products. Compounds 4a–4d contain the same [FeIII·{FeNO}7] center, with identical chemical formulas, Fe2(N-Et-HPTB)(NO)(OH)-(DMF)2](BF4)3, and identical electronic absorption spectra (Fig. S3). They display small to moderately different structural features that most likely arise from the variable solvent molecules trapped in the crystal lattice. Selected bond lengths, angles, and NO stretching frequencies for these [FeIII·{FeNO}7] complexes (4a–4d) and the [FeII·{FeNO}7] complex, 3 are collected in Table 1 (see Fig. S4 for IR spectra). Relevant structural parameters and νNO for the complexes 4a–4d are quite similar to that reported for 5a and 5b (Table 1, footnote). In the preparation of 4c and 4d, the bridging benzoate of 2 is lost upon reaction with Ph3CSNO, and a hydroxide ion, generated from water in the starting materials, binds terminally to the non-nitrosylated iron center. As a result of the benzoate loss, the Fe—Fe separations increase to 3.622 Å (4c) and 3.615 Å (4d), compared with 3.575 Å in 2. The Fe—ON-Et-HPTB distances are distinctly different (Table 1) for the two iron centers in 4a–4d, reflecting the different oxidation states of the metal and in a manner similar, but not identical, to that observed for the diiron(II,III) compound, 2.20 The presence of short and long Fe—ON-Et-HPTB bond distances that are not as extreme as those in 2 (Table 1) is consistent with the [FeIII·{FeNO}7] formulation of the iron centers in 4a–4d. Mössbauer parameters obtained for 3 (Fig. 2), 4a (Fig. 2), and 4b–4d (Fig. S2 and S5) are very similar to that observed previously for 5a17 (δ = 0.67 mm/s, ΔEQ = 1.44 mm/s), indicating presence of a {Fe(NO)}7 species in both 3 and 4a–4d. Compound 3 should give rise to a doublet for Fe (II) site with 70% relative area and a doublet for Majumdar and Lippard Page 2 Inorg Chem. Author manuscript; available in PMC 2014 December 02. N IH PA Athor M anscript N IH PA Athor M anscript N IH PA Athor M anscript {FeNO}7 having 30% relative area. The observed data (Fig. 2) reveal 64% Fe(II) site and 36% {FeNO}7 site, is in close agreement with this prediction. In DMF solution, compound 4a displays two irreversible reductions (Fig. 3, see Fig. S7 for reproducibility in repeated scans); identical results were obtained for 4b. By comparison to the presence of the irreversible, two-electron reduction in the dinitrosyl diiron compound, 5b, at −1.1 V,18 the reduction of 4a at −1.14 V can be assigned to the {Fe(NO)}7 center. The reduction at −0.64 V therefore corresponds to the FeIII(OH) center. Reduction of the {Fe(NO)}7 unit in 4a might lead to partial release of NO− and generation of an additional Fe(II) center in solution. Such behavior would possibly account for the presence of two oxidative waves on the reverse sweep (Fig. 3), one at −0.59 V and the other at −0.85 V, corresponding to oxidation of {Fe(NO)}7 and denitrosylated material. One additional feature in the CV is a small oxidation at −0.04 V, which we tentatively assign to restoration of an FeIII(OH) unit. In DMF solution, 4a exhibits a broad electronic absorption spectroscopic feature centered at 600 nm (ε = 225 ± 6), a shoulder at 490 nm (ε = 377 ± 9), another weak shoulder at 420 nm (ε = 1424 ± 42), and a strong UV band at 302 nm (ε = 5910 ± 57) (Fig. 4, Fig. S3). This solution reacts rapidly with O2 as revealed by a change in color from light brownish-green to dark bluish-green (λmax = 600 nm, ε = 725 ± 17; Fig. 4a). The green solution is unstable at room temperature and full bleaching of the 600 nm band occurs within 5 h (Fig. 4b). A similar situation occurs for solutions of 4b–4d (Fig. S6), consistent with their identical chemical nature. The identity of the green species is currently under investigation. In conclusion, mononitrosyl diiron compounds having an [FeIII·{FeNO}7] formulation and with slightly varying Fe—N—O bond angles have been synthesized and characterized. The synthetic strategy used to achieve such mononitrosyl complexes relied on the presence of mixed valent character in the initial diiron core. Diiron(II) starting materials under identical conditions yielded either no or only partial nitrosylation to form products with a formal[FeII· {FeNO}7] core. The work described here reveals the important role of iron oxidation states for controlling the nature of the nitrosylation in diiron complexes in a symmetrical ligand environment. It is possible that FNORs might adopt a similar strategy to genera


With a conventional positioning apparatus, it is very difficult simultaneously to achieve desired driving ranges and precision levels at the sub-micrometer level. Generally, a lead screw and friction drive have been used as servo control systems. These have large driving ranges, and high-speed positioning is feasible. In this study, we present a global servo system controlled by a laser interferometer acting as a displacement measurement sensor for achieving positioning accuracy at the sub-micrometer level.


BACKGROUND In the last few years we have witnessed a revolution in the treatment of hepatitis C virus (HCV) infection. With the introduction of direct-acting antiviral agents (DAAs), sustained virological response (SVR) is achieved in more than 95% of the patients. The focus is now being turned to the global targets set by the World Health Organization, with the aim of achieving HCV elimination by 2030. Prison inmates constitute one of the high-risk groups, and receive treatment less frequently due to several barriers in access to health care. AIM To describe the management and follow-up of a cohort of HCV monoinfected patients treated with DAA in the prison setting, where tertial referral liver center specialists locally provide, on-site assessment and treatment for the prisoners. METHODS A prospective observational study was conducted from April 2017 to March 2020, which included all HCV monoinfected prison inmates in the largest Northern Portugal prison. Demographic, clinical, and laboratory data, as well as transient elastography measurements, were collected onsite by the medical team and prospectively recorded. Patients were treated with DAA according to international guidelines. The primary endpoint was SVR at post-treatment week 12. RESULTS There were 98 monoinfected HCV male inmates (mean age, 42.7 ± 8.6 years) included in the analysis. Injecting drugs or tattooing were reported in 74.5%, with 38.8% of the latter being done in prison. Alcohol consumption of more than 30 g/d was referred in 69.4%. The most prevalent genotype was 1a (54.1%), followed by 3 (27.6%), 4 (9.2%) and 1b (6.1%). Pretreatment fibrosis degree was mild-to-moderate (F0-F2) in 77.6% and severe in 22.4% (F3-F4). Treatment regimens chosen were: 45.9% elbasvir/grazoprevir, 29.6% sofosbuvir/velpatasvir, and 12.2% sofosbuvir/ledispavir and glecaprevir/pibrentasvir. No major adverse events were observed. SVR at post-treatment week 12 was 99%. CONCLUSION In a population considered to be both hard-to-access and a cornerstone for HCV elimination, the onsite evaluation and treatment of HCV-infected prisoners, achieved an exceptional highly effective success rate. This type of collaborative program should be considered to be expanded, to support hepatitis C elimination efforts.


ABSTRACT The faunal remains recovered from the Neolithic and Metal Age Nagsabaran shell midden site in Cagayan, Northern Luzon Philippines were analyzed to gain insights into the arrival of managed animal populations, subsistence patterns, and animal processing during the occupation of the site around 2000 cal BC to within the last 1,500 years. Introduced pigs are present from the earliest recognized phases of settlement, but dogs are only evident from the Late Neolithic/Metal Age onwards. The faunal assemblage is dominated by wild taxa suggesting the reliance on hunting for subsistence even up to the Late Metal Age (1350 BP). There was no intensification in animal husbandry, even in the presence of domestic animals, which is in contrast to other sites in the region dating to the same period and demonstrates regional variability in the resource importance of introduced domestic taxa. Analysis of skeletal element representation in the assemblage revealed that whole carcasses were being brought to the site and processed, and systematic analysis of the butchery marks permitted the description of carcass processing sequences. Over-representation of certain skeletal elements, and the presence of finished tools suggests the on-site manufacture of bone implements during the later phases of site occupation.


This work presents a circle detection algorithm for the purpose of detecting roundabout central islands in single-layer laser scans. The algorithm is robust against measurement errors and imperfections of the central island's circular form and it can be used for laser scanners with only a few vertical layers. Main features of the algorithm are the semi-convex segmentation and curvature-based segmentation steps and the use of an a priori digital map to classify the detected circles. Experimental results show that, based on its performance, the method can be integrated in a real-time online roundabout perception system for highly automated vehicles.


The adsorption of toluene from aqueous solution using waste tyre rubber granules (WTRG) was investigated in a batch system. The effect of various factors such as contact time, amount of adsorbent, size of adsorbent particles, and temperature of solution on the adsorption capacity of WTRG was determined. The equilibrium contact time was obtained to be 30 minutes indicating fast adsorption. The adsorption capacity of WTRG increased with decrease in particle size. Increasing the temperature of the aqueous solution resulted in a decrease in the adsorption capacity of WTRG while an increase in adsorbent dosage resulted in an increase in the adsorption capacity of WTRG. Kinetic and isotherm studies indicate that the adsorption of toluene was best described by the Lagergren pseudo-first order kinetic equation and Langmuir isotherm equation respectively. Results obtained indicate that recycled rubber from scrap tyres can be widely used as an adsorbent for the removal of toluene from aqueous solution.