The major health hazard of the modern world, "Metabolic Syndrome" or "Syndrome X", defined by WHO, as pathologic condition characterised by abdominal obesity, insulin resistance, hypertension and dyslipidemia [1]. The criteria for diagnosis are listed in Figure 1 [2]. It is being accepted almost a decade ago that we are in the phase of epidemic for this Non Communicable Condition. Though it was started in western world, spread of western lifestyle across the globe, truly it has now become the major global issue. Until recently the condition was far more prevalent in urban population than rural but in today's time, especially in Country like India, the incidence showed trends towards becoming almost equal [3]. Though recognised all over the world, the condition is rather dealt as managing different component(s) of the syndrome rather than taking the syndrome per say as diagnosis. We rather tend to care much of those patients who actually show prominently one or more components of metabolic syndrome, and this approach is leading us to neglect rather major bulk of patients who, in spite qualifying for criteria of diagnosis of metabolic syndrome, where not only patients are in early asymptomatic phase, but also the physicians caring for them do not reinforce the importance of the needed care at this very moment to prevent or delay the progression of the condition. Healthcare all over world, particularly in India has shown enormous growth, in terms of not only infrastructure but also skill development [4]. Today we do have much better level of expertise in all the subspecialty with regards to high end care of all such conditions arise from one or more components of metabolic syndrome like Heart Failure, Chronic liver disease, chronic kidney disease and Diabetes (related complication). In developing country like India, somewhere 3 to 4 decades ago to subject a patient for liver or kidney transplant used to be mere dream of treating consultants but today we are not only doing the transplants smoothly but also survival rate is getting better and better [5]. But its quiet unfortunate that in spite of all these progresses, the actual numbers of such patients needing high end care is steadily on rise, thanks to increase in life expectancy in general and relatively better exposure to needed healthcare [5]. But author do strongly believe that still whatever we are seeing is more at treatment cum cure level but nothing much at prevention level is going on. In decades to come, we have large population at risk, at this very moment, for all such advanced staged chronic metabolic conditions. We are in genuine need of a molecule which can be offered to all such early or intermediate metabolic syndrome patient, expecting the improvement in almost all the aspect on the syndrome. Author do believe, the group of drugs known as "SGLT2 Inhibitors", an originally used for Hyperglycemia management, has now expanded its preventive effects on various metabolic conditions, showing promising results in all the trials and early real world evidences, is the real nomination for the "Metabolic Molecule" or "Disease modifying anti metabolic drugs- DMAMDs" of today.


Pharmacokinetics of metformin was evaluated following its single dose administration alone and administered with erlotinib and/or meloxicam in SCID mice. Following administration of metformin as a single drug in male SCID mice, the mean values of observed peak plasma drug concentration (Cmax), time of maximum concentration (Tmax), area under plasma drug concentration-time curve (AUC0-), volume of distribution (Vz), elimination half-life (t1⁄2β) and total body clearance (Cl) were 6277.75 ± 404.25 ng/ml, 0.61 ± 0.10 h, 17218.83 ± 885.71 ng.h/ml, 28950.33 ± 3629.19 ml, 3.36 ± 0.27 h and 5897.32 ± 350.95 ml/h, respectively. Erlotinib and/or meloxicam administration was found to alter pharmacokinetic profile of metformin in SCID mice. Thus, close therapeutic monitoring should be followed for long term concomitant administration of these drugs. However, study on clinical pharmacokinetic interaction of these drugs is required to evaluate interaction in human patients.


I n breadth and consistency , Schnitzler's diary is among the most significant of German and European literature. In 2000, the Austrian Academy of Sciences finished its project of publishing the ten 400 to 500 page volumes of Schnitzler's diary, having started in 1981 to bring order to his entries between 1879 and his death in 1931. Predictably, easier access to the diary confirmed the suspicion that Schnitzler brooded over concerns far more multifarious than love and death, something astute readers had known for decades. Beyond serving to support interpretations of texts or to prove Schnitzler was capable of diversity, the diary became an object of scrutiny in its own right, reflecting a determination, especially in Vienna, to prove that this man's legacy was worth preserving. The discipline demanded by such prolific journal writing could alter the image of a man so long considered impressionistic before the First World War and out of step afterwards. What has been shown to be consistent and trustworthy is, after all, worth preserving. In the scholarship that discusses Schnitzler the diarist and autobiographer, or in the biographical approaches that rely on these genres, an ambivalent fascination has emerged not always to the liking of Schnitzler aficionados. The turn toward non-fiction has shone the spotlight more brightly on Schnitzler's complexity, but also on his pathologies. The Diary Project (1981–2000) Schnitzler's diary wrote predictability into his life as a bulwark against the unpredictable. Made credible by excruciating self-honesty, the diary became his anchor against an experience of slippage rivaling that of his characters.


Background: In addition to its role in calcium and phosphorus metabolism, calcitriol (1,25‐dihydroxyvitamin D; 1,25‐D3) demonstrates multiple effects on cell proliferation/differentiation by expressing major histocompatibility complex (MHC) antigens and intercellular adhesion molecule‐1 (ICAM‐1). It has recently been reported that 1,25‐D3 inhibits the growth of prostatic cancer (PCa) cells. In this study we examined the effect of 1,25‐D3 on both the growth and expression of HLA‐ABC, HLA‐DR and ICAM‐1 antigens in PCa cells.


The morphology, growth rate and anatomy of the fused vein trait were characterized in Cucurbita pepo using the inbreds NH2405 (fused vein), NH7210 (moderately fused vein), and NH614 (normal). Morphological analysis showed that the trait is characterized by a partial fusion of the five primary leaf veins. Fusion begins at the distal point of the petiole and extends along the central vein. Branching of the veins is delayed and there is a reduction of the interveinal leaf blade. Consequently, the upper leaf surface appears puckered or wrinkled. Depending on genetic background, the onset of fused vein leaf production starts at the fourth to tenth leaf stage and continues throughout maximum extent of vein fusion also varies with genetic background (5-20 cm). Though fused vein and normal inbreds differed in the rate and pattern of leaf growth, examination of F 2 and BC populations revealed no significant effect of the fused vein trait on leaf number, leaf size, and rate of leaf initiation. Anatomical examination revealed different vascular patterns in the transition zone between petiole and leaf blade for normal and fused vein leaves. In normal leaves, the vascular bundles of the petiole enlarge and coalesce to form a vascular crescent. The crescent reorganizes and diverges as large vascular columns and pairs of smaller flanking vascular bundles into each vein. In contrast, two cycles of enlargement, coalescence, and dispersal occur in fused vein leaves. vegetative growth. The extent of fusion increases with leaf number but stabilizes by the twentieth leaf stage As a species, Cucurbita pepo displays considerable variation in vegetative structures (Whitaker and Davis, 1962). Mature plants range from compact, single-stem bushes to rambling, multi-stem vines. Juvenile leaves are frequently three-lobed, while mature leaves have five shallow to deep lobes with narrow to wide sinuses. Leaves also show subtle variation in leaf size, trichome harshness, and surface mottling. However, only two genes affecting leaf structure have been reported. The dominant gene mottled, M, produces silver gray areas in the axils of leaf veins (Scarchuk, 1954). The recessive gene rosette, ro, imparts a spiraled appear- ance to the lower leaf lobes (Mains, 1950). A new C. pepo mutant leaf form, fused vein (FV), has shown potential as a roguing marker for hull-less seeded pumpkin culti- vars (Carle and Loy, 1991). The trait was first observed in 1987 among segregating material descending from a cross between 'Tricky Jack' and 'Minijack'. It has since been fixed in two hull- less seeded inbred lines, NH2405 and NH7210. In both lines, it is expressed before flowering and imparts a distinctive, conspicuous leaf morphology. The trait is rare and inherited stably (Carle and Loy, 1996a). Limiting its use to hull-less material can provide outcross detection from hulled contaminants. The purpose of this study was to characterize the morphology and anatomy of the FV trait and to determine its role in leaf development. Using selected breeding lines, the extent and stabil- ity of the FV phenotype were ascertained as well as its effect on general growth rate.


This study describes the impact of septic tanks on the groundwater quality of the shallow Pleistocene aquifer in Jericho area, Westbank, Palestine. Septic tanks are widely used for storage and disposal of sewage in the populated and agricultural city of Jericho. Routine hydrochemical tests for groundwater quality performed for several years identified the problem of a gradual nitrate increase, without pinpointing its definite sources. The geological formations of the Jericho area and the shallow nature of the Pleistocene aquifer, together with the mechanism of recharge, make the groundwater in this aquifer highly susceptible to contamination, particularly along sewers. The lithology of the Samara (high hydraulic conductivity) and the Lisan formation (low conductivity but increased infiltration along fractures) promote easy seepage of agricultural and anthropogenic inputs into the groundwater. Nitrate concentrations are elevated near septic tanks and animal farms, with nitrate values exceeding 74 mg/L. δ 15 N nitrate and δ 18 O nitrate signatures suggest sewage and manure as the main sources of high nitrate concentration in the groundwater. Samples taken during the end of the dry season indicate that a slight denitrification in the aquifer.


— Cymopterus higginsii nnd Penstetnon atwoodii are named and described from materials collected in the Kaiparowits Plateau vicinity of eastern Kane County. Utah. Habitat, distribution, and probable affinities are outlined. Examination of specimens obtained from the Kaiparowits Plateau region of eastern Garfield and Kane counties in southern Utah has revealed the existence of two previously undescribed entities, one each in Cymopterus (Apiaceae) and Penstemon (Scrophulariaceae). Existence of these taxa is not surprising when one considers the historic remoteness of much of that great region. The discovery and the extent of the range of each taxon must be credited to the extensive field workallowed under the baseline studies of the Navajo-Kaiparowits enA'ironmental project directed by personnel from Brigham Young University (Welsh, Murdock, and Wood 1975). The Cymopterus species is known from saline soils of the Tropic Shale formation and associated pedimental gravels on fans and bajadas below the Straight Cliffs formation in that portion of Kane County from the Paria River eastward to the Last Chance Creek vicinity. Apparent relationships of C. higginsii seem to lie with C. fendleri from which it differs inter alia in the rose to purple flowers with evident pedicels and wider wings on the fruit. The pseudoscape is poorly developed. The corollas in the Penstemon species are glandular hairy externally, and the taxon seems to belong with those species treated by Pennell (1920) as Section Crista ti and by Keck (1938) illegitimately as Section Aurator. The nearest ally appears to be P. jamesii from which P. atwoodii differs as noted in the diagnosis. P. atwoodii is known only from middle elevations of the Kaiparowits region, where it grows on the Cretaceous formations in juniper-pinyon woodland. Both species, the Cymopterus and the Penstemon, are plants of very restricted range. They are in areas which are now subject to commercial exploitation, and both should be considered as threatened


This research explores dynamical innovation of the school open up its stadiums publicly.The research is based on the dialectical relationship between the main interests of school and benefits of opening stadiums resources to the public This is a issue concerning how to effectively balance the government dialectical relationship among government,schools and the public on the basis of own interests.It is necessary to clarify "public welfare" and "the main interests" and convey "mutual benefit,inclusive and win-win" public ideas.The research is meant to advance theoretical possibility for our city school stadiums resources to open to the public.


In the magnitude 5.6 Newcastle, N.S.W earthquake of 28 December 1989, the area with highest seismic intensity (MM VIII) was located some 10 km from the epicentre. In the absence of local instrumental data for the event, various explanations of the intensity distribution have been advanced. A causative relationship has been suggested, with support from wave propagation calculations, in the close spatial correlation between the area with highest seismic intensity and the area with alluvial and/or fill cover. An alternative interpretation correlates intensity primarily with structural vulnerability rather than site geology. New evidence for amplified response of alluvial sites has been obtained from a microtremor monitoring experiment using 1-Hz seismometers


Abstract A device has been developed, to characterize the stickiness of materials prone to shearing that is based on torque measurement during intermittent stirring. Experiments were carried out, using materials of various origin, and over a range of moisture contents that span the pasty to free-flowing powder consistencies. To reflect the complex nature of stickiness, often noted by researchers during the drying of slurries and pastes, the concept is proposed, of a stickiness region, adjacent to the stickiness curve. Referring to the two-dimensional visualization of a drying process with evolving moisture content and material temperature, possible trajectories are suggested, to deal with the stickiness problem. #The copyright is held by © Her Majesty the Queen in Right of Canada, as represented by the Minister of Natural Resources, 2003.


Abstract Approximation sequences and derived equivalences occur frequently in the research of mutation of tilting objects in representation theory, algebraic geometry and noncommutative geometry. In this paper, we introduce symmetric approximation sequences in additive categories and weakly n-angulated categories which include (higher) Auslander-Reiten sequences (triangles) and mutation sequences in algebra and geometry, and show that such sequences always give rise to derived equivalences between the quotient rings of endomorphism rings of objects in the sequences modulo some ghost and coghost ideals.


We demonstrate two ways in which the optical band-gap of a 2-D macroporous silicon photonic crystal can be tuned. In the first method the temperature dependence of the refractive index of an infiltrated nematic liquid crystal is used to tune the high frequency edge of the photonic band gap by up to 70 nm as the temperature is increased from 35 to 59°C. In a second technique we have optically pumped the silicon backbone using 150 fs, 800 nm pulses, injecting high density electron hole pairs. Through the induced changes to the dielectric constant via the Drude contribution we have observed shifts up to 30 nm of the high frequency edge of a band-gap.


The invention discloses a frame assembly for a two-wheel self-balancing electric vehicle, which aims at providing a stably-driven and flexible self-balancing electric vehicle with two independently driven wheels. The frame assembly for the two-wheel self-balancing electric vehicle comprises a left connecting frame group and a right connecting frame group which correspond to each other, wherein fixing surfaces for fixing vehicle bodies and wheels are arranged on the connecting frame groups and used for fixing both bodies and wheels of left and right single-wheel self-balancing electric vehicles; handles are mounted at the upper parts of the connecting frame group; two corresponding pedal plates are arranged below the connecting frame groups; and a central connecting bearing group is mounted on a corresponding surface between the two connecting frame groups. Compared with the prior art, the frame assembly for the two-wheel self-balancing electric vehicle, disclosed by the invention, is advantaged in that the flexibility of the vehicle is obtained while the safety of the vehicle is improved and great driving interests are brought to drivers.


Abstract Drug courts are often the last chance for criminal justice-involved persons with substance use disorders to avoid incarceration. Given this stark reality, participation in drug court should not be influenced by race. This study tracks cohorts of drug court referrals to compare referral, admission, and graduation rates by race in two states and eight counties in diverse regions of the United States. We compared admission and graduation rates by race in each state or county using tests of the difference between independent proportions, displayed graphically with longitudinal state-level data. Black persons had lower referral and admission rates in nearly all jurisdictions for which requisite data were available, and lower graduation rates in six of the ten jurisdictions. In statewide analyses for which adequate longitudinal data were available, racial differences in admission and graduation rates persisted for up to a decade. Practice and policy recommendations are offered to improve measurement of cultural disparities in drug courts and the broader justice system and implement remedial strategies.


Unmanned aerial vehicles (UAVs) represent an assistance solution for home care of dependent persons. These aircraft can cover the home, accompany the person, and position themselves to take photographs that can be analyzed to determine the person's mood and the assistance needed. In this context, this work principally aims to design a tool to aid in the development and validation of the navigation algorithms of an autonomous vision-based UAV for monitoring dependent people. For that, a distributed architecture has been proposed based on the real-time communication of two modules, one of them in charge of the dynamics of the UAV, the trajectory planning and the control algorithms, and the other devoted to visualizing the simulation in an immersive virtual environment. Thus, a system has been developed that allows the evaluation of the behavior of the assistant UAV from a technological point of view, as well as to carry out studies from the assisted person's viewpoint. An initial validation of a quadrotor model monitoring a virtual character demonstrates the advantages of the proposed system, which is an effective, safe and adaptable tool for the development of vision-based UAVs to help dependents at home.


Background. Incidence of dental caries in primary school children is still relatively high. This corresponds to a pattern of wrong eating habits, a supportive environment such bad habits like sweet snacks, less fibrous and easily sticky. In addition the frequency of irregular brushing teeth also contribute to the occurrence of dental caries. The purpose this study was to determine the relationship between the frequency of brushing teeth with dental caries incidence of grade 2 students SDN Sumberagung II Klego. The hypothesis taken by the researchers is suspected there is a relationship between the frequency of brushing teeth with dental caries incidence in Class 2 SDN Sumberagung II Klego. This study was conducted in SDN II Suberagung Klego. Methods used is the correlation method with cross sectional approach, the number of samples of 50 people the sampling technique used is total sampling The conclusion From the results of data processing, the chi squere obtained x2 count equal to 9.314 and 3.841 on the table at the 0.05 significance level and degrees of freedom equal to 1 so that the count is greater than x2 table which means there is a relationship between the frequency of brushing teeth with dental caries incidence in 2nd grade students of SDN Sumberagung II Klego. This shows that with regular brushing can minimize the occurrence of dental caries Keywords : Dentis caries, Dental Care and Teeth Brushing


"And the second is like unto it, Thou shalt love thy neighbour as thyself" (Matthew 22:37–39). As President Thomas S. Monson taught last general conference, keeping one commandment helps us keep the other: "We cannot truly love God if we do not love our fellow travelers on this mortal journey. Likewise, we cannot fully love our fellowmen if we do not love God, the Father of us all. . . . We are all spirit children of our Heavenly Father and, as such, When a lawyer asked Jesus which of the commandments was the greatest, He could have chosen any of the many commandments from the Old Testament, from the law of Moses, or from the Ten Commandments. Instead, He summarized all of the commandments in these two: "Thou shalt love the Lord thy God with all thy heart, and with all thy soul, and with all thy mind. "This is the first and great commandment. LOVE THY NEIGHBOR AS THYSELF "As we arise each morning, let us determine to respond with love and kindness to whatever might come our way." —President Thomas S. Monson W H A T W E B E L I E V E


Larval development, pupation and adult emergence of black cutworms were investigated using 16 possible larval food sources. Food sources included crop plants, weeds and field debris. Larval survival was highest on bluegrass, curled dock and wheat while no larval survival occurred on giant foxtail or debris. Larval development from egg to pupa varied from 24.6 days on wheat to 47.0 days on annual morning glory.


With over 27 years' of development and application work behind it, Nautronix is a company with subsea acoustics in its DNA. David Morgan looks at the company's provenance and projects, including the recent deployment of its NASNet technology in the deepest subsea production development to date ― Petrobras' Cascade-Chinook in almost 3000m of water in the Gulf of Mexico.


Background: Turnaround time (TAT) is an important quality indicator in blood banking. This study evaluated the effectiveness of the pneumatic tube system (PTS) to reduce TAT and its effect on the quality of the blood products. Materials and Methods: The PTS (Swisslog GMBH, Germany) which connects to 29 stations was installed at our 2032-bedded tertiary care referral center. The system transports the carrier at an average speed of 25 feet/s (7.6 m/s). Acknowledgment slips were sent along with the blood components through this carrier system to know the time of receipt. Quality control parameters were checked before and after PTS transport in 10 bags of each of the blood components (packed red blood cells [PRBC], platelet concentrate, and fresh frozen plasma [FFP]). Data were analyzed using IBM SPSS Statistics 20. Results: PTS was used for 220 events to deliver 69% PRBC (n = 152), 15% FFP (n = 34), 14% platelets (n = 30), and 2% cryoprecipitate (n = 4), respectively, to 11 destinations. The average transport time by PTS was 1.36 ± 0.34 min and for human-based transport, it was 7.92 ± 1.40 min and this difference was found to be statistically significant (P < 0.001). The mean latent time was 5.85 ± 4.39 min. Conveyance in the PTS did not reinforce any negative changes on the quality of any blood component. Conclusion: PTS is rapid and reliable for the transport of the blood products to bedside.


Qin and Han Dynasties belonging to the early sequencing of word order.The word order was sort in diversity and based on significance in this period.Shuo Wen method is the summit during the Qin and Han Dynasties.The radical discourse and the department of Chinese characters in Shuo Wen based on structure of Chinese characters.On this basis,its come to ideographic radical and sort,then establish radicals.The semantic radical system used to sort,rather than search.


Objective: A GC determination for the content of ethanol in fentanyl transdermal systems was developed. Method: In the determination,glass column filled with GDX-103 stationary phase, nitrogen as the carrier gas and FID detector were adopted. The column temperature was 110 ℃. Result: The method recovery for ethanol is 100.1% with RSD 1.3%(n=10). Conclusion: The method is simple, rapid and reliable.


The economic constraints to the use of liming materials in the smallholder-sector make it necessary to know their effect on crop yields as well as their potential benefits to the soil resource, namely the changes in soil properties that are expected to result from various rates of application. Studies have shown that the addition of Ca-containing materials to soil not only changes the chemical and physical properties of the soil, but also affects the availability of nutrients to plants (Simard et al., 1988; McLay & Ritchie, 1993; Mora et al, 1999). The effects of these materials on the chemical composition of the soil solution, and on availability of both macroand micronutrients differ with the material, and also with the soil type. Consequently, it is necessary to understand, and be able to predict the effects of Ca-containing materials on soil solution composition of the soils, and the resultant effects on plant growth.


It is more difficult for recovery upper limb functional than lower extremity after stroke,especially the recovery of hand function,because the effect is not obvious in short-term so it is easily overlooked.This article will make a summary about the rehabilitation progress of the hand dysfunction after stroke,and make a prospect about the development in future.


The performance of 49 range hoods has been tested. The tests were done acoording to Regulation (EU) No 65/2014, that specifies the tests for the energy label of range hoods. The results are evaluated and solutions for problematic tests are suggested.


Nanopores have been proven as versatile single-molecule sensors for individual unlabeled biopolymer detection and characterization. Besides application to next gene sequencing, proteins are becoming a prime target of investigation. In our work, single molecules of bovine serum albumin have been detected as the transient current blockages while the proteins pass through a silicon nitride nanopore. Characterization of transition signals at different biased voltages reveals that globular protein translocating through nanopore is different from the linear DNA, with larger current amplitude and longer transition time due to the protein adsorption with nanopore. The results will shed light on the understanding of protein transport cross an individual biomimetic nuclear pores.


This paper presents a novel yokeless and segmented armature (YASA) axial-flux in-wheel motor with amorphous magnetic material (AMM) stator cores for a solar-powered electric vehicle. Although this new axial-flux in-wheel motor has many advantages such as high efficiency, shorter axial length, and high power density, its working condition is complicated. In-wheel motors are usually operated in electromagnetic, thermal, and other multiphysics environments. Increasing the performance requirements of in-wheel motors, such as power density, efficiency, and reliability, requires a multiphysics design approach. The focus of this paper is on the analysis of electromagnetic characteristics, losses, temperature distribution, mechanical behavior and other characteristics of the axial-flux in-wheel motor. The back electromotive force (EMF) and electromagnetic torque of the motor with harmonic current are obtained by the 3-D finite element method (FEM). The permanent magnet (PM) eddy-current losses when using different PM shapes are studied. The equivalent thermal model of the tape-wound AMM stator segments and the windings are established, and the temperature distribution of the motor is obtained. The mechanical behavior of the stator segments and the rotor disks when the motor is eccentric and axially offset is analyzed, and the structural strength of the motor is evaluated. Finally, a prototype of the motor is fabricated, and the electromagnetic performance and temperature of the motor are tested to verify the accuracy of the multiphysics design approach.


It is shown that a certain system of differential equations of importance to the proof of stabiity of the adaptive system proposed in [ 11, admit unbounded solutions. The implication of this resnlt is that a much more elaborate argument than heretofore thought necesary is required to prove that the adaptive system of [l] is stable.


This paper aims to contribute to the analysis of the shortfalls and challenges in the Brazilian federal normative system that regulate the access of third sector organizations (TSOs) to public funding and its service delivery role. Its initial background is a set of legal reforms conducted by the federal government that took place in the 1990s when, at the same time, denouncements of public money misappropriation involving these organizations became more frequent.


Introduction: The utility of F‐waves in assessing radiculopathies is debated. The aim of this study is to determine the frequency of abnormal minimum tibial F‐wave latencies compared to an F‐estimate and an absolute reference value in patients with electromyography (EMG) confirmed S1 radiculopathies. Methods: A retrospective review of F‐waves in patients with an EMG‐confirmed isolated S1 radiculopathy was performed. The minimum and mean latencies of 8 tibial F‐waves were compared with the calculated F‐estimate and to an absolute reference value, and the frequencies of abnormal responses were determined. Results: Of the 50 patients with an S1 radiculopathy, 4% had prolongation of the minimum reproducible F‐wave latency, and 8% had prolongation of the mean latency relative to the calculated F‐estimate. Conclusions: The minimum and mean F‐wave latencies are infrequently abnormal when compared with an estimated F‐wave latency in S1 radiculopathies and are insensitive in the assessment of S1 nerve root injury. Muscle Nerve 49: 809–813, 2014


This paper presents the result of an investigation on the application of the acoustic emission method to the monitoring of fatigue crack initiation, growth and track location in welded joints. Fatigue test was carried out for a typical fillet welded joint of ship structure. AE parameter such as ring down count was analyzed in time domain and crack locations were examined by source location and cluster option which is one of the functions of AE signal processor The usability of AE mettled was confirmed for the detection of the initiation and location of through crack.


An important picture by Antonio Triva recently appeared on the art market with an erroneous attribution to Pietro della Vecchia. Painted during Triva's sojourn in Bavaria, this work belongs to a cycle of paintings that once adorned the Gallery of the Residenz in Munich. Triva carried out the decoration of the Gallery between 1669 and 1673, having been commissioned by Henrietta Adelaide of Savoy to posthumously celebrate Maximiliam I Wittelsbach, Prince Elector of Bavaria. The cycle consisted of a series of paintings on canvas with allegories and scenes from the life of the prince, many of which were dispersed when the Gallery was demolished at the beginning of the nineteenth century. The identification of the painting is confirmed in a description of the Residenz by Ranuccio Pallavicino, who was responsible for the iconographical programme. Triva's work, originally set on the ceiling of the Gallery, represents "The Chest of Maximilian I with the Instruments of Penitence", as described in the biography of the prince.


Heres another set of amazing stories by musicians from all over the world! This time Im taking you along for a ride through the city of Detroit,  a ...


The present invention relates to a method for the treatment of biosolids, the method produces a high value, a nitrogen-containing, sustained release, enhancement of organic and inorganic fertilizers, fertilizer and fertilizer competition lower value, or the more expensive conventional commercial manufacture. The method comprising adjusting the wastewater biosolids in conventional manufacturing equipment and high-throughput continuous processing conditioned biosolids. Heat dissipation design and closed-loop control of the main reaction vessel significantly reduces the amount of power required to run the device manufacture. Compared with the traditional process plant, the method using a green technology for waste reduction and improved air quality standards. Bio-solid waste from the production of fertilizer is recovered safe and meet or exceed the US Environmental Protection Agency (USEPA) A special class and quality standards, and is not restricted or regulated.


Determining access information technology accessible to a phase change memory (PCM) device will be described. In one embodiment, the final read time based on the PCM cell, the set and the reset threshold voltage information to determine the threshold voltage shift of the PCM initial read time, read time, and wherein the final definition of the initial read time to read PCM cells the time window. In another embodiment, the extended drift time window is determined based on the reset threshold voltage.


ABSTRACT Commercially important marine fish, yellowfin tuna (YFT), and swordfish (SF), collected from the Indian Ocean around Sri Lanka were analysed for mercury (Hg) and cadmium (Cd) content. The ranges for Hg were < 0.07–1.60 and < 0.07–4.30 mg/kg, while for Cd < 0.006–0.134 and 0.006–0.180 mg/kg in YFT and SF, respectively. In SF 13.3% and in YFT 9.2% exceeded the 1 mg/kg limit for Hg, while 3.1% of YFT exceeded the 0.1 mg/kg limit for Cd. All other samples were well below the maximum limits. Human health risk assessment was investigated using Estimated Daily Intake, Total Hazard Quotient, Hazard Index, and Provisional Tolerable Weekly Intake values for Hg and Cd. The data indicated that the current YFT and SF consumption pattern in Sri Lanka poses no threat to consumer's health. However, further research and awareness on food safety aspects is needed on specific groups such as children and for areas in which consumption of seafood is high.


Natural Language Processing techniques play an essential role in extraction of necessary information for ontology construction from unstructured text. Identifying syntactic constituents and their dependencies in a sentence, boost the information extraction from natural language text. Main ingredients required for ontology construction are required to be extracted from text in the form of entities and relations between them. Language dependency constructs that express the binary dependencies of the lexical terms in a sentence can be considered as good indicators in identifying binary relationships existing between entities. In this paper we describe that how the typed dependencies produced by a natural language parser are used by a multi agent system to generate rules for relation extraction between two identified entities. The typed dependencies produced by parsing are processed to eliminate unnecessary dependencies and make them more appropriate to be used in rule learning for relation extraction. All the relations derived are expressed as predicate expressions of two entities. We evaluate our agent system by applying it on number of wikipedia web pages from the domain of birds.


Preface.- Acknowledgements.- List of Tables.- Specific Group Activities and Exercises.- The Challenge of Providing Mental Health Services in Schools.- Evidence-based Tier 1, Tier 2 and Tier 3 Mental Health Interventions in Schools.- Strengthening School-Counseling Interventions.- Affect Education at Tiers 1, 2, and 3.- Importance of Emotion Regulation Training for Children and Adolescents.- Emotion Regulation Training at Tiers 1, 2, and 3.- Support for the Use of CBT in Schools.- Preparing Young and/or Disabled Children to Benefit from CBT in School-based Settings.- CBT in Schools.- Sustainability, Current Programs and a Look to the Future.- References.


360° video brings an immersive experience to users by projecting panoramic content onto the display. Viewing 360° videos on untethered mobile platforms further enhances the immersive user experience. As a result, a large number of systems for optimized high-resolution 360° video streaming to mobile devices have been proposed over the past few years. In this paper, we review the diverse set of research methodologies in the system design and evaluation of recently proposed mobile 360° video streaming systems and discuss a number of pitfalls that prevent a fair and meaningful comparison among different systems. Our discussion suggests that there is an urgent need to redefine the design objectives and to develop an effective methodology for a meaningful evaluation and comparison of different systems. We finish with a set of concrete guidelines on the design and evaluation methodology of future mobile 360° video systems.


In 1759 the British captured Surat Castle. This later turned out to be one of the first steps towards what would soon become their Indian empire. This paper aims to re-examine the history of events leading to this Castle Revolution on the basis of the altogether neglected Dutch sources at the National Archives in The Hague. To make sense of what appears to be a decade of ongoing revolutions and endless jockeying for power, the paper proposes the existence of an underlying mechanism of highly flexible networks that connected and encompassed the various political and commercial, local and interregional, maritime and continental spheres of Surat's open-ended political economy. With this in mind, the paper also briefly reassesses the current idea of the so-called Anglo-Bania order and takes a critical look at the neutralist discourse of the Dutch sources.


adaptive perfectionism (12 items; e.g., 'My best just never seems to be good enough for me') and standards perfectionism (7 items; e.g., 'I set very high standards for myself'). ANOVA compared groups on the test variables, controlling for demographics where appropriate. All significance tests were two tailed with the level of significance set at p < 0.05. Regarding demographics, the samples only differed in age. The CFS group and the healthy controls were not significantly different in age. However, the CFS group was significantly younger than the IBS [t(324) = –3.07, p < 0.01] and the FM/arthritis group [t(324) = –3.38, p < 0.01]. ANCOVAs found that maladaptive but not standards perfectionism levels differed significantly between the groups ( table 1 ). Planned pairwise comparisons revealed that maladaptive perfectionism was significantly higher in the CFS group than in the healthy controls [mean difference (95% CI): –0.71 (0.29–1.13), p < 0.01, d = 0.53], the IBS group [–0.53 (0.09–0.97), p < 0.05, d = 0.37], and the FM/arthritis group [–0.63 (0.17–1.09), p < 0.01, d = 0.49]. There were no other significant differences in perfectionism. Regarding coping strategies, the CFS group scored higher on behavioral disengagement coping than the healthy controls [–0.34 (0.11–0.57), p < 0.01, d = 0.44] and the FM/arthritis group [–0.35 (0.09–0.60), p < 0.01, d = 0.48]. Parallel differences were found for self-blame coping with the healthy controls [–0.40 (0.13–0.66), p < 0.01, d = 0.45] and the FM/arthritis group [–0.28 (0.01–0.57), p = 0.05, d = 0.33]. The correlations between perfectionism types and the two coping strategies were computed for the CFS group and the healthy controls. Maladaptive perfectionism was significantly correlated with self-blame coping in the CFS group (r = 0.56, p < 0.01) and the healthy controls (r = 0.30, p < 0.01). A Fisher z test revealed that the magnitude of this correlation was significantly larger for CFS (z = 2.11, p < 0.05). The correlation between maladaptive perfectionism and behavioral disengagement coping was also significant for the CFS group (r = 0.35, p < 0.01) and the healthy controls (r = 0.30, p < 0.01). However, these correlations did not differ significantly (z = 0.36, p = 0.72). Standards perfectionism was not significantly correlated with self-blame coping in the CFS group (r = 0.12), but was negatively correlated in the healthy controls (r = –0.44, p < 0.01). The magnitude of these correlations significantly differed (z = 3.81, p < 0.01). The correlations with behavioral disengagement coping were negative in the CFS group (r = –0.27, p < 0.01) and the healthy controls (r = –0.44, p < 0.01), but not significantly different (z = 1.26, p = 0.10). In the IBS group, maladaptive perfectionism was significantly correlated with each of the 4 maladaptive coping styles (r values from 0.34 to 0.64, p < 0.01), whereas standards perfectionism negatively correlated with denial (r = –0.25, p < 0.05) and behavioral disengagement (r = –0.32, p < 0.01). In the FM/arthritis group, maladaptive perfectionism was significantly correlated with all but substance use coping (r values from 0.32 to 0.43, p < 0.01); standards perfectionism was not significantly correlated with any of the coping strategies. Biopsychosocial models of chronic fatigue syndrome (CFS) posit that personality and stress have predisposing and perpetuating roles in the persistent and unexplained fatigue that characterizes this functional somatic syndrome [1] . Studies indicate that many CFS patients are characterized by an achievement-oriented and perfectionistic personality, and that such tendencies coupled with self-criticism drive these individuals to work beyond the point of exhaustion in a way that may initiate or perpetuate chronic fatigue [2] . Research has differentiated between the role of holding high personal standards (standards perfectionism) and having self-critical thoughts about trying to achieve ideal standards (maladaptive perfectionism) in CFS [2] . The latter has been linked to poor outcomes including heightened stress sensitivity [3] . Although research indicates that CFS patients use maladaptive coping strategies more than healthy controls [4] , it is unknown whether this is true relative to other chronic illness groups. Because maladaptive perfectionism is linked to poor coping responses [5] , we examined perfectionism dimensions and maladaptive coping styles in CFS patients compared with healthy controls and two other chronic illness groups. Participants were drawn from a larger sample of communitydwelling adults from the USA or Canada (n = 980) who completed an anonymous online survey on personality and health after providing informed consent. We selected individuals who indicated on a medical checklist that included 13 different chronic health conditions that they had been diagnosed by a medical professional with CFS, irritable bowel syndrome (IBS), or fibromyalgia (FM)/ arthritis for 3 subsamples. The remaining participants were screened for the presence of other chronic diseases, leaving a final healthy sample of 564 subjects, which was divided into 6 random samples of comparable size to the illness groups, one of which was randomly chosen as the healthy control group. The Brief COPE [6] , a 28-item self-report measure of 14 different coping styles, assessed 4 maladaptive coping strategies: behavioral disengagement, substance use disengagement, denial, and self-blame. The Revised Almost Perfect Scale [7] assessed malReceived: February 18, 2014 Accepted after revision: June 10, 2014 Published online: October 16, 2014


This article presents a computational framework for estimation of the mean in two‐phase sampling mechanism using multi‐auxiliary variables when observational errors are observed in sample data. A competent class of estimators is proposed which encompasses several existing estimation techniques under observational error. The properties of the proposed class of estimators have been explored under large sample approximation using the Taylor series expansions method. A strive is done to obtain the optimum sample sizes for a certain cost of the survey. The impact of observational errors is assessed over the mean square error of the estimators. The simulation study is demonstrated to reflect the dominant nature of the proposed class of estimators over the existing one.


Even though Material Bookings modules have existed in some form for over 20 years, studies remain curiously absent from the literature. In an effort to begin this dialogue, a case study of implementing Innovative's Material Bookings module at the University of Nebraska at Omaha's Criss Library is presented. A survey assessing user satisfaction and experiences with Material Bookings and self-booking were distributed to the Innovative User Group's LISTSERV, and the findings are reported in this text.


Introduction: The pyruvate dehydrogenase complex (PDC) is a multienzyme complex responsible for catalyzing the oxidative decarboxylation of pyruvate to Acetyl-CoA. A defect in any of its components can interfere with the production of energy on a cellular level; within these disorders we find pyruvate dehydrogenase (PDH) deficiency characterized by clinical neurological and systemic signs of varying severity, highlighting lactic acidosis, neurological and progressive neuromuscular deterioration. Objective: Describe the case of a female, school aged patient with characteristic craniofacial dysmorphology, neurodevelopmental delay and episodes of metabolic decompensation due to infections, with a mutation in the PDHX gene, treated with a ketogenic diet, thiamine, lipoic acid and carnitine. Results: The findings that made it possible to focus the diagnosis were elevated plasma and CSF lactate levels associated with persistent metabolic acidosis with accentuation of hyper intensity in the cortical sulci and in the in the bilateral basal ganglia and lenticular nuclei region of the brain on magnetic resonance imaging. Magnetic resonance imaging with spectroscopy showed a negative peak of lactate. Confirming the diagnosis with an exome of 6000 genes where a homozygous pathogenic variant is found in the PDHX gene position c.1426C> T. Conclusion: PDH deficiency should be considered in cases of neurodevelopmental delay associated with intermittent episodes of neurological deterioration and elevated blood lactate and as well as elevated lactate in magnetic resonance spectroscopy of the brain. Unlike those affected by other subtypes, patients with E3-binding protein deficiency often survive childhood and even adulthood due to the presence of assembly to a certain extent of some of the pyruvate dehydrogenase complex. Prompt diagnosis opens the possibility of starting early supportive management, providing genetic counseling to parents, as well as establishing prognosis.


The author thinks that many errors in English writing arise from wrong mode of expression. This paper, through comparing the difference between English and Chinese in four sides, analyses the negative effect of Chinese thinking on English writing and puts forward the suggestions.


since past few years there has been a remarkable rise in the popularity of touch screen mobile phone devices. With respect to the data and information that can be stored on the mobiles as well as mobiles are nowadays are also used for accessing mail and connecting to social media, it is necessary to ensure the security of the data and information that is stored on the mobiles. User authentication is an important security measure for protecting the information stored on the mobile phone devices, because these devices have a higher risk of theft. In order to prevent unauthorized access to these devices, passwords and other pattern based authentication method are being used in recent time. However, password-based authentication has an intrinsic weakness in password leakage. While the patterns are easy to steal and reproduce. In this paper, we introduce an implicit authentication approach that enhanced the password pattern with additional security layer. We provide three security checks in two steps. The three authentication methods used are time taken to draw the pattern which is a behavioral biometric authentication method, password pattern (shape) and match the angle (3 dimensions) of mobile. Keywords-component; password pattern; implecit authenticatio; Angle of mobile


Based on activation and synergistic effect among various materials, a low-cost cementing material, FGC binder, was prepared by using fly ash, granulated blast-furnace slag (BFS), carbide slag and compound activator. The results showed that the immobilization efficiency of FGC binder for Pb is higher than that of OPC cement. The hydration products and mechanism of immobilization were analyzed by using XRD. The major products of FGC binder are C-S-H, C-A-H, ettringite and zeolite-like materials. Under the experimental conditions, the Pb2+ curing efficiency of FGC binder is 1.04 ~ 1.24 times that of ordinary Portland cement.


Urban redevelopment project was aimed for recovery, and it was mainly concentrated in adjusting small plots, narrow roads, and unequal pieces of land. Ever since the first urban redevelopment project in 1970s, more than half of the whole sectors are finished or in progress and downtown improved a lot compared with that of the past. Now, urban redevelopment project is facing the new situation. Not only unoperated districts, but also old completed-districts are causing problems because worn-out structures of those are now behind of fashion and they lack harmony with other adjoined districts. To redevelop redevelopment-completed districts swiftly, urban-design approach to changing paradigm and revitalization of project in unoperated-districts are crucial. Also, through revision to the laws including balance of redeveloping sectors and various infrastructure, we have to operate redevelopment project flexibly, which will make us contribute to specialized urban management plan.


This paper presents the design and measurement of an adaptive 3-tap feed-forward equalizer (FFE) integrated circuit (IC) manufactured in 28-nm digital bulk CMOS technology. The driver consumes only 100 mW from a single 1.5 V supply including the vertical-cavity surface-emitting laser (VCSEL) and excluding the input matching circuitry. The 50 Ω input baluns, necessary only for the measurement, are not power optimized and consume 60 mW. The driver was assembled on a printed circuit board (PCB) with DC connections and bonded to a commercially available 7.5 GHz VCSEL diode. An error-free (BER < 10−12) optical transmission with a data rate (DR) of 25 Gbit/s was achieved. It is proven that the 3-tap FFE improves the quality of the optical eye diagram at a cost of eye amplitude. When not needed, the circuitry of the FFE can be switched off saving 22.5 mW of power.


.............................................................................................................................. ii Acknowledgements ............................................................................................................ iv 1.0 Introduction ................................................................................................................... 1 2.0 BACKGROUND .......................................................................................................... 6 2.1 Heritage Claims and Contestations ........................................................................... 6 2.2 The Van Duzen/Yager Creek Watershed .................................................................. 8 2.3 Institutional History of YES ................................................................................... 10 3.0 METHODS ................................................................................................................. 12 3.1 In-depth interviews ................................................................................................. 13 3.2 Casual Interviews .................................................................................................... 15 3.3 Participant Observation ........................................................................................... 15 3.4 Document Review ................................................................................................... 16 4.0 LITERATURE REVIEW ........................................................................................... 18 4.1 Cultural Resource Laws .......................................................................................... 18 4.2 Significance and the National/State Registers ........................................................ 20 4.3 Dynamic Processes ................................................................................................. 24 4.4 Heritage as a Social Practice ................................................................................... 25 4.5 Conflicting Heritage Representations and a Shared Heritage Ethic ....................... 26 4.6 Working Landscapes and Ranching Heritage: Challenges and Solutions .............. 28 5.0 AGENCY PERSPECTIVES OF HERITAGE............................................................ 33


Today, in the manufacture of long-length rail strings, the obligatory heat treatment is provided after the flash butt welding operation. The basis for this operation is the unsatisfactory mechanical properties of the rail joints immediately after welding. Welding heat cycles at pulsed reflow do not always allow a welded joint with a sufficient level of ductility to be obtained. In this case, the induction heat treatment used at rail welding enterprises in Russia increases the length of the heat-affected zone, which adversely affects the wear resistance of the rails during operation. This paper presents studies in industrial conditions that were previously conducted in laboratory conditions. Studies show the possibility of obtaining the necessary mechanical properties by controlling welding heat cycles without the use of induction heat treatment.


Goal of the bachelor thesis were to wrote a literature review, designed the blow mould for required part, drew 3D model of the part, carried out movement analysis and drew whole injection mould using CATIA P3 V5R15 tool. Function system of mould has established of full automatization machine cycle. Required plastic part is powdery sifter compound of polyethylen material.


The purpose of this chapter is to introduce a few components that are common to most (if not all) pattern recognition or machine learning systems, including a few key concepts and building blocks. Some commonly encountered issues are also discussed. We will use face recognition as an example to introduce these components, and use the nearest neighbor classifier as a simple solution to the face recognition problem.


OF DISSERTATION CHRISTOPHER ROUSE: AN EXPLORATION OF THREE PERCUSSION STANDARDS The percussion ensemble is still a relatively young ensemble, with the first works by Edgard Varèse and Amadeo Roldan composed in the first third of the 20 century. Because of this youth, it is important to examine significant works for the percussion ensemble which establish themselves as staples to the repertoire. Christopher Rouse, a Pulitzer-Prize winning composer has written three such works, Ogoun Badagris (1976), Ku-Ka-Ilimoku (1978), and Bonham (1989). This study will closely examine each of these works, providing background, detailed analysis, and performance practice for each of these works.


Midbrains of ten young adult rats were sectioned serially in three planes to study the detailed cytoarchitecture of the substantia nigra. These neurons measure 8 to 17 μ in diameter. In comparison, the largest neurons in the midbrain measure 20 to 40 μ; hence, neurons are designated according to size as follows: those measuring 18 to 40 μ, large; 12 to 17 μ, medium; and 8 to 11 μ, small. The substantia nigra of the rat contains non-pigmented neurons in three divisions: pars reticulata, pars compacta, and pars lateralis. The pars reticulata is the largest division and has the longest rostrocaudal extent. It contains neurons of small size medially and of medium size laterally. This finding correlates with described differences in connections. Three-dimensionally, the pars reticulata is an oblate spheroid with the long axis in the rostrocaudal plane. The pars compacta is a triangular layer dorsal to reticulata. It is subdivided into rostral and caudal portions at the level of the fibers of the basal optic root. Neurons in both subdivisions are medium in size, but cells rostrally are darker than those caudally. The pars lateralis is a column of neurons with its long axis located in the rostrocaudal plane. It lies dorsolateral to the pars reticulata and the pars compacta, with occasional connections to both by cellular strands. The pars lateralis has rostral and caudal portions; neurons rostrally are medium in size and round; caudally, however, neurons are variable in size, dark, stellate or fusiform, and have long processes.


Being overweight or obese might be a risk factor for developing depression. It is also possible that low cardiorespiratory fitness, rather thanoverweight orobesity, is thebetter predictorof depressivesymptomonset.Adults in the Aerobics Center Longitudinal Study (Dallas, Texas) underwent fitness and fatness assessments between 1979 and 1998 and later completed a questionnaire about depressive symptoms in 1990, 1995, or 1999. Separate logistic regressionmodels were used to test the associations between 3 fatnessmeasures (bodymass index, waist circumference, and percentage of body fat) and the onset of depressive symptoms. Analyses were repeated using fitness as the predictor variable. Additional analyses were performed to study the joint association of fatness and fitness with the onset of depressive symptoms. After controlling for fitness, no measure of fatness was associated with the onset of depressive symptoms. In joint analyses, low fitness was more strongly associated with the onset of elevated depressive symptoms than was fatness, regardless of the measure of fatness used. Overall, results from the present study suggest that low fitness is more strongly associated with the onset of elevated depressive symptoms than is fatness. To reduce the risk of developing depression, individuals should be encouraged to improve their fitness regardless of body fatness.


The full words can be used to refer to something in the world,for the full words,this reference function is intrinsic.After expounding the reference function of the words,then the paper analyses in detail how the reference function of the words come true.Finally,the paper explains the meaning of "reference" of all disciplines in the linguistics.


In this paper, we study the degraded multiple-access channel (MAC) with confidential messages, where two users transmit their confidential messages (no common message) to a destination, and each user obtains a degraded version of the output of the MAC. Each user views the other user as a eavesdropper, and wishes to keep its confidential message as secret as possible from the other user. Measuring each users uncertainty about the other users confidential message by equivocation, the inner and outer bounds on the capacity equivocation region for this model have been provided. The result is further explained via the binary and Gaussian examples.


Nowadays, traveling has been transformed drastically into a-must-do activity to ensure that they can keep update on what's trending now. Today there are a whole bunch of advertisements which attract people to go traveling the world. And this phenomenon is strengthen with the abundance amount of online traveling applications like Traveloka, PegiPegi, Tiket.com, Agoda, Airy, AirBnb, and many more lists which make traveling become much more practice and pretty easier. Based on those facts, this research aims to explore more about how big the influence of the advertisements and online traveling applications will affect people to go traveling as well as to examine about about the ways traveling influences people's perspective in seeing the world. This research used ethnomethodology as the research design since it discusses much about the traveling phenomenon in relation with people's perspective and response in seeing the world outside. The data were gathered through online questionnaire in the Facebook group of 'Backpacker Dunia' which consist of twenty submitted questionnaires. Personal data analysis (through questionnaire and interviews) was performed to test whether the influence of advertisements and online traveling applications will affect people to go traveling and whether traveling influences people's perspective in seeing the world or not. The data analysis were conducted by using qualitative descriptive method. The results revealed that in the end they realized that traveling is always the best way to learn about everything, including about the culture and the ways people seeing the world. In short, there will always be the symbol (relationship between words), the referent (something or the thing it describes), and the meaning (the thought which is related to the word and the thing).


Compiler scalability is a well known problem: reasoning about the application of useful optimizations over large program scopes consumes too much time and memory during compilation. This problem is exacerbated in polyhedral compilers that use powerful yet costly integer programming algorithms to compose loop optimizations. As a result, the benefits that a polyhedral compiler has to offer to programs such as real scientific applications that contain sequences of loop nests, remain impractical for the common users. In this work, we address this scalability problem in polyhedral compilers. We identify three causes of unscalability, each of which stems from large number of statements and dependences in the program scope. We propose a one-shot solution to the problem by reducing the effective number of statements and dependences as seen by the compiler. We achieve this by representing a sequence of statements in a program by a single super-statement. This set of super-statements exposes the minimum sufficient constraints to the Integer Linear Programming (ILP) solver for finding correct optimizations. We implement our approach in the PLuTo polyhedral compiler and find that it condenses the program statements and program dependences by factors of 4.7x and 6.4x, respectively, averaged over 9 hot regions (ranging from 48 to 121 statements) in 5 real applications. As a result, the improvements in time and memory requirement for compilation are 268x and 20x, respectively, over the latest version of the PLuTo compiler. The final compile times are comparable to the Intel compiler while the performance is 1.92x better on average due to the latter's conservative approach to loop optimization.


O-Glucuronidation of 5-hydroxyrofecoxib is the major biotransformation pathway of rofecoxib in human, rat, and dog. The glucuronide conjugate is also involved in the reversible metabolism of rofecoxib in rat and human. Atypical bimodal phenomena were observed in their plasma concentration-time curves with a large variability among different human subjects. It is unclear which family members of human UDP-glucuronosyltransferases (UGT) are involved in the formation of the glucuronide. O-Glucuronidation of 5-hydroxyrofecoxib by human liver microsomes and eight cDNA-expressed human UGT isoforms were investigated. Human liver microsomes formed 5-hydroxyrofecoxib glucuronide with apparent Vmax value of 1736 pmol/min/mg of protein and Km value of 44.2 M. Eight individual cDNA-expressed human UGT isozymes (1A1, 1A3, 1A4, 1A6, 1A8, 1A9, 2B7, and 2B15) were evaluated for glucuronidation of 5-hydroxyrofecoxib. Among them UGT2B15 exhibited the highest metabolism rate with apparent Vmax value of 286 pmol/min/mg of protein and Km value of 16.1 M, whereas UGT2B7 showed apparent Vmax value of 47.1 pmol/min/mg of protein and Km value of 41.6 M. These results indicated that human UGT2B15 has the highest level of activity for catalyzing the glucuronidation of 5-hydroxyrofecoxib. Because polymorphisms have been identified in human UGT2B7, 2B15 genes and O-glucuronidation of 5-hydroxyrofecoxib plays a major role in biotransformation of rofecoxib, it is possible that human UGT2B7 and 2B15 polymorphisms for O-glucuronidation of 5-hydroxyrofecoxib are responsible for the high variability in bimodal patterns in human plasma concentration-time curves. Rofecoxib, 3-phenyl-4-[4-(methylsulfonyl)phenyl]-2(5H)-furanone, is highly selective for inhibition of the inducible form of cyclooxygenase (COX-2) and is marketed by Merck as an anti-inflammatory drug (VIOXX) for the treatment of arthritis and pain (Chan et al., 1999; Prasitet al., 1999). The absorption, distribution, metabolism, and excretion of rofecoxib in rat, dog, and human have been reported (Halpin et al., 2000, 2002). Rofecoxib was extensively metabolized with the major metabolites as 5-hydroxyrofecoxib and its O-glucuronide conjugate. In the rat, an unusual feature of the plasma concentration versus time profile for rofecoxib following oral administration was the presence of a distinct second Cmax. Similar phenomena were also observed in human pharmacokinetic profiles with a large variability among different subjects. It was suggested that the atypical bimodal phenomena in plasma concentration-time curves were due to reversible metabolism of 5-hydroxyrofecoxib to rofecoxib (Baillie et al., 2001). The 5-hydroxyrofecoxib was metabolized to its glucuronide conjugate and excreted in bile. The glucuronide metabolite was deconjugated in the lower gastrointestinal tract, resulting in 5-hydroxyrofecoxib. Reduction of the 5-hydroxyrofecoxib formed a hydroxyacid that cyclized spontaneously to regenerate rofecoxib, which was reabsorbed and entered the systemic circulation. The second Cmax was due to reabsorption of rofecoxib formed from 5-hydroxyrofecoxib glucuronide in the lower gastrointestinal tract. Since O-glucuronidation of 5-hydroxyrofecoxib plays a major role in biotransformation and reabsorbtion of rofecoxib in human, it is interesting to identify human UGT enzymes responsible for the glucuronidation of 5-hydroxyrofecoxib. To date no human UGT isoform responsible for the glucuronidation of 5-hydroxyrofecoxib has been reported. The primary goal of the present investigation was to determine which human UGT isoforms are responsible for the glucuronidation of 5-hydroxyrofecoxib and to understand the mechanism of high variability in pharmacokinetic patterns in human subjects. 5-Hydroxyrofecoxib was incubated with human liver microsomes and eight cDNA expressed human UGT isoforms from 1A and 2B subfamilies that are involved in xenobiotic metabolism (Mackenzie et al., 1997; Jedlitschky et al., 1999). The incubated samples were analyzed by LC-MS coupled with UV detection. For active UGT isoforms, kinetic parameters were determined and compared with those determined for human liver microsomes in an attempt to better explain the variation in clearance of the compound. Materials and Methods Chemicals. [C]Rofecoxib and 5-hydroxyrofecoxib were synthesized as described previously (Halpin et al., 2000; Baillie et al., 2001). Uridine diphosphoglucuronic acid (UDPGA), saccharic acid-1,4-lactone, alamethicin and -glucuronidase (Helix Pomatia) were purchased from Sigma-Aldrich (St. Louis, MO). Pooled human liver microsomes were obtained from Xenotech (Kansas City, KS). Recombinant human UGT1A1, 1A3, 1A4, 1A6, 1A8, 1A9, 2B7, and 2B15 expressed in baculovirus-infected insect cells (Supersomes) were purchased from BD Gentest (Woburn, MA). 5-Hydroxyvaldecoxib was obtained from Pharmacia compound files. (Skokie, IL). All other chemicals and reagents were of analytical grade and available commercially. 1 Abbreviations used are: COX-2, cyclooxygenase II; UGT, UDP-glucuronosyltransferases; UDPGA, UDP-glucuronic acid; HPLC, high performance liquid chromatography; LC-MS, liquid chromatography-mass spectrometry. Address correspondence to: Dr. Ji Y. Zhang, Pharmacia, 4901 Searle Parkway, Skokie, IL 60077. E-mail: email@example.com 0090-9556/03/3105-652–658$7.00 DRUG METABOLISM AND DISPOSITION Vol. 31, No. 5 Copyright © 2003 by The American Society for Pharmacology and Experimental Therapeutics 1048/1061001 DMD 31:652–658, 2003 Printed in U.S.A. 652 at A PE T Jornals on Sptem er 0, 2017 dm d.aspurnals.org D ow nladed from Assay for Human Liver Microsomal UGTs. In a typical incubation, 0.25 mg of human liver microsomes, 0.1 M potassium phosphate (pH 7.1), 5 mM saccharolactone, 50 mg alamethicin, 1 mM MgCl2, and 20 M 5-hydroxyrofecoxib in a final volume of 0.5 ml were preincubated at 37°C for 10 min. To initiate the reaction, UDPGA (5 mM in incubation) was added and incubated at 37°C for 0 to 60 min in a shaking water bath. Control incubations were performed without human liver microsomes or without UDPGA. The reaction was stopped with 1 ml of 0.1% formic acid in ice-cold acetonitrile or methanol. The samples were centrifuged to remove precipitated protein and the supernatants were transferred and evaporated to dryness under nitrogen gas at room temperature. The samples were reconstituted in mobile phase A (see HPLC-UV and LC-MS) and analyzed by HPLC and LC-MS. Assays for cDNA-Expressed Human UGT Isoenzymes. All reaction mixtures contained 10 mM potassium-phosphate buffer (pH 7.1), 1 mM MgCl2, 5 mM saccharolactone, and 20 M 5-hydroxyrofecoxib in a total volume of 0.5 ml. Expressed human UGT1A1, 1A3, 1A4, 1A6, 1A8, 1A9, 2B7, and 2B15 with a protein concentration of 0.5 mg/ml were added and preincubated at 37°C for 10 min. The reaction was initiated by the addition of 5 mM UDPGA and incubated at 37°C for 0 to 60 min in a shaking water bath. Control incubations were performed without UDPGA. The reaction was terminated with 1 ml of 0.1% formic acid in ice-cold acetonitrile or methanol. The samples were centrifuged to pellet precipitated protein. The supernatants were transferred and evaporated to dryness under nitrogen gas under room temperature. The samples were resolved in mobile phase A and analyzed by HPLC and LC-MS. -Glucuronidase Hydrolysis. The O-glucuronide of 5-hydroxyrofecoxib produced from human liver microsomes as mentioned above was isolated by HPLC, dried under nitrogen gas, and reconstituted in 1.5 ml of 0.2 M sodium acetate buffer (pH 5.0). Aliquots (0.5 ml) of each sample were incubated in the absence (control) and presence of 200 units of -glucuronidase (SigmaAldrich) for 16 h at 37°C in a shaking water bath. The incubations were stopped by the addition of 1 ml of acidified ice-cold methanol (0.1%). After evaporation to dryness under nitrogen gas, the samples were resolved in mobile phase A and analyzed by LC-MS. Stability of O-Glucuronide of 5-Hydroxyrofecoxib. 5-Hydroxyrofecoxib glucuronide from in vitro incubations with human liver microsomes was resolved in 0.2 ml of each buffer, with specific pH values of 3, 6, 7, and 9. The resulting mixtures then were injected immediately onto the LC-MS system and re-injected at an interval of 2 h over a 6-h period after standing on an autosampler at room temperature. For each pH mixture, the time for the first injection was considered as the starting time (time 0). HPLC-UV and LC-MS. HPLC-UV and LC-MS analyses were performed using an Agilent HPLC system (1100 series) linked to a Thermo Finnigan LCQ-Deca ion-trap mass spectrometer (San Jose, CA). The MS was equipped with an electrospray interface. The LC system consisted of an autosampler, an HPLC pump, and a diode-array detector (Agilent Technologies, San Fernando, CA). The separation was carried out on a Zorbax phenyl column (2.1 150 mm, 5 m; Agilent Technologies) at ambient temperature with a linear gradient system that was programmed from 100% mobile phase A to 100% mobile phase B in 20 min, followed by isocratic condition of 100% mobile phase B for 5 min. The system then was programmed back to 100% mobile phase A in 1 min and re-equilibrated for 5 min before the next injection. The flow rate was 0.2 ml/min. Mobile phase A consisted of acetonitrile/water/formic acid (5:95:0.1, v/v/v), and mobile phase B consisted of acetonitrile/water/formic acid (20:80:0.1, v/v/v). The effluent from HPLC column passed through the diode-array detector, monitored at 280 nm, then introduced into the mass spectrometer. The mass spectral analysis was performed using electrospray ionization in negative ion mode. The source voltage and current were set up at 5 kV and 80 A, respectively. The capillary voltage was set at 4 V, with the heated capillary temperature held at 200°C. The optimum collision energy for MS/MS was in the range of 20 to 30% of normalize collision energy. Three events were carried out for the analyses


A precise method for separating the dissipation factors associated with conductor losses and dielectric losses of printed circuit boards through a wide range of microwave frequencies is presented. This method accomplishes separation by utilizing the difference in dependence of the two losses on the dimensions of triplate-line resonators composed of printed circuit boards. To efficiently separate these two losses, a parameter which is a function of only the dimensions of the triplate-line resonator is used. Effective conductivity and the anisotropy of the conductivity in the industrial copper foil utilized for cladding is measured against surface roughness by using this method. At 10 GHz the measured effective conductivities of electrodeposited copper foil and oxygen-free rolled copper foil are about one-third and one-half that of DC conductivity, respectively. Experimentally, the anisotropic characteristics of oxygen-free rolled copper foil was clearly demonstrated. >


This study aims to determine the foreign policy of the United States that
implemented in Sudan since Sudan is a country that experienced a prolonged
ethnic conflict. The issue of human rights violations as well as civilians who
became victims because of the ethnic conflict triggered the need for outside
intervention Sudan.
At first the get the official mandate of the UN Security Council to
intervene in the Sudan is the African Union, but the United States is also active in
implementing foreign policy in Sudan, humanitarian intervention, and as a
mediator in resolving the ethnic conflict in Sudan. Foreign policy that run the
United States to Sudan have some consideration, first to resolve ethnic conflicts in
Sudan, both for the United States national interest related to the natural resources
that exist in the Sudan, particularly Southern Sudan.
The way taken by the United States in carrying out its foreign policy in
Sudan despite criticism from the international community but the United States
succeeded in running its foreign policy in Sudan. This is evidenced by the
referendum Sudan peace between North and South Sudan in 2005 and in 2011 the
South Sudan officially broke away from the Sudan. That means South Sudan has
officially become its own country and has been recognized by other countries. For
the national interest in neganya United States has managed to establish bilateral
relations with Sudan, the United States proved today is the largest recipient of
petroleum products from the Sudan, especially from Southern Sudan.


The purpose of this study is to quantify the lesser trochanteric version and determine the angle and the relationship between lesser trochanter and femoral neck version. Investigate the influence of the lesser trochanter version in the width of ischiofemoral space. Two hundred and fifty asymptomatic hips were evaluated with axial magnetic resonance image. The lesser trochanter version was calculated. The difference between the femoral neck version and the lesser trochanter version formed the angle between each structure. The width of ischiofemoral space was measured and its relationship with the lesser trochanter version was determined. The mean lesser trochanter version was −24° ± 11.5° (range, − 54° to + 17°) with a coefficient variation of 47.45%. The mean femoral neck version measured 14.0° ± 10.8° (range, −16° to 50°), with a coefficient variation of 81.32%. The lesser trochanter/femora neck angle was 38.4° ± 9.6° (range, 8° to 67°), coefficient variation of 30%, with a moderate correlation between the structures (r = 0.63, P < 0.01). The mean ischiofemoral space was 22.9.0 ± 7.0 mm (range, 10.3 to 55 mm), and a weak correlation was found between ischiofemoral space and lesser trochanteric version (r = −0.16, P < 0.05). The lesser trochanteric version showed a high variation with a moderate relationship with the femoral neck version. The lesser trochanteric version does not influence the width of the ischiofemoral space.


The basic principle of time difference method used in the ultrasonic measurement system,and the low power implementation of wind sonsor based on CPLD and MSP430 are introduced.The ultrasonic emission drive and part of the receiving circuit are provided,the second-order active Butterworth bandpass filter is calculated.For high precision measurement,the method of the peak envelope detection that is used for recognizing the ultrasonic arrived time is proposed,and method of CPLD for high speed counting is also proposed.The realization process of ultrasonic meacuring wind is described in detail.Experimental results show that the system has high precision and low power consumption,which is worthy spreading.


A mobile application erasing method and a mobile terminal. The method comprises: performing encryption processing on a read/write operation of an enterprise mobile application to generate a mobile security application; receiving a data writing request of a user with regard to the mobile security application, and if identity verification of the user is passed, then recording feature information about written data after the mobile security application writes data according to the feature information; receiving policy information sent by a mobile application management server; and executing an erase instruction on the mobile security application according to the policy information, and erasing application data of the mobile security application according to the feature information.


© The Author 2023. Published by Oxford University Press. This is an Open Access article distributed under the terms of the Creative Commons AttributionNonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact firstname.lastname@example.com permissions, please email: Josh Toth, Truth and Metafiction: Plasticity and Renewal in American Narrative (New York: Bloomsbury, 2021), 247 pp.


Mix designs and specimen preparation with different manufacturing process of sulfur rubber concrete(SRC) were investigated. Compressive strength with or without corrosion, toughness and microstructure were studied and discussed. The results show that SRC have good corrosion-resistance. Although compressive strength of SRC decreases with increasing rubber content, the toughness enhances. Adding micro-filler improves compressive strength of SRC. There is a threshold value for the sulfur content, at which the compressive strength and the workability of SRC reaches an optimum balance. The bond between rubber particles and surrounding sulfur is strong due to the vulcanization process that generates cross-links through S-C bonds.


Similar to counties such as the UK and Netherlands, second level schools in Ireland are free to decide how to allocate instruction time between curriculum subjects. This results in variations between the quantum of time allocated to teaching mathematics in different schools and between different class groups within the same school. This quantitative study builds a profile for both lower second level (Junior Cycle) and upper second level (Senior Cycle) mathematics instruction time in Ireland. The results of the study highlight that although the proportion of time is on par with the OECD average, there are many issues of concern regarding instruction time in Ireland. These include the short length of the school year, experimentation with new teaching approaches, the high number of subjects studied, variations between individual school and class group allocations and the number of classes that do not take place.


Abstract Social media has helped intensify the velocity and volume of information shared on the Internet. A flood of information from a multitude of viewpoints and in a wide array of mediums is unleashed on the public daily. Unfortunately, the information falls on a wide spectrum of veracity—from completely true, to somewhat true but misleading, to utterly false. While we may partially blame hostile foreign or domestic actors for seeding false information into the public consciousness, information users need to understand their own roles, often played unwittingly, in sharing that information. In this study we attempted to advance our understanding of the phenomena of information sharing, especially when false information is involved, and demonstrate that information literacy is the best line of defense against false information. After a historical overview of how librarians dealt with propaganda and false information, we present a conceptual framework for understanding why people share information, especially false information, using examples from social media and other digital communication channels. We also discuss the consequences of sharing false information. We conclude with literacy strategies for equipping information users with the knowledge and skills to assess, process, and respond to shared information effectively.


A simple green method was developed for rapid synthesis of silver and gold nanoparticles (AgNPs and AuNPs) has been reported using Lonicera japonica flower extract as a reducing and a capping agent. AgNPs and AuNPs were carried out at 70 oC. The successful formation of AgNPs and AuNPs have been confirmed by UV-Vis spectro photometer, fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), energy dispersive X-ray Analysis (EDAX), scanning electron microscopy (SEM) and high-resolution transmission electron microscopy (HRTEM). To our knowledge, this is the first report where Lonicera japonica flower was found to be a suitable plant source for the green synthesis of AgNPs and AuNPs.


During HAART, HIV RNA can be detectable (>50 cop/mL) in CSF when it is undetectable in plasma, a condition termed CSF viral escape (CVE). The aim of the current analysis was to determine the prevalence and risk factors for CVE in two large US cohorts.


The destructive power of addictions manifests itself in ill health effects, social and family problems, and economic and legal troubles. Psychologists' role within this arena include researching the effects of drug action, studying the epidemiology and etiology of drug and alcohol abuse, developing and evaluating prevention and treatment programmes, and studying the effects of drug policies on human behaviour. This extensive collection of reprinted articles from American Psychological Association journals provides a current view of psychological research on addictive behaviours.


The aim of our study was to assess absolute counts of different subpopulations of circulating endothelial cells (CEC) in patients with active and inactive systemic lupus erythematosus (SLE). We have also investigated a potential correlation of CEC numbers with serum levels of angiogenic proteins as well as with clinical and laboratory symptoms of the disease. For the first time in SLE, CEC were enumerated directly, by the 'single platform' method. Resting (rCEC), activated (aCEC) and progenitor (pCEC) endothelial cells were identified in patients with SLE and healthy volunteers using four-colour flow cytometry. Serum concentrations of angiogenic proteins (vascular endothelial growth factor, placental growth factor (PIGF), soluble vascular cell adhesion molecule and endoglin) were evaluated by ELISA. The SLE activity was scored according to the Systemic Lupus Activity Measure system. We found that total CEC number in patients with SLE was significantly higher (median 14.2/μL) than in the control group (median 3.3/μL) (P < 0.0001). Absolute counts of aCEC, rCEC and pCEC (medians 4.9/μL, 6.8/μL and 2.3/μL, respectively) were also higher in patients with SLE than in healthy persons (medians 0.9/μL, 1.6/μL and 0.1/μL, respectively), with P < 0.0001 for all comparisons. There was no correlation between CEC or their subpopulations and SLE activity. Strong positive correlations were found between CEC, rCEC and pCEC numbers and serum levels of PIGF. Moreover, aCEC, rCEC and pCEC counts were significantly higher in SLE patients with leukopenia. In conclusion, our results show that absolute CEC counts and angiogenic proteins levels are elevated in patients with SLE as compared with healthy controls. These data may suggest that angiogenic process is involved in the pathogenesis of this disease.


I want to go through a sort of personal progression that has taken place in myself and is also reflected in my work. I think I evolved from a place where I had a complete and honest non-awareness of issues of people of color, to the place where I am now-which is continuing to evolve, but is closer to some sort of multicultural model. When I first started writing plays I had no particular desire to write about myself as an Asian American or as a person of color. Perhaps as a result of that the first few plays I wrote, which are either in a drawer of mine or buried someplace, nobody's ever seen. At a certain point I started to awaken to issues of color, in the late '70s when I was an undergraduate in college. Partially this was through the awareness of works by Asian Americans who had come before me. Directly as a result of people like Frank Chin and Maxine Hong Kingston and other non-Asian writers like Ntozake Shange, I became aware of the possibility of opening up this side of myself in my work. When I wrote my first play, F.O.B., to some extent it was an attempt to validate the existence of a previous Asian American literary tradition, through an exploration of two mythological characters: Fa Mu Lan, from Maxine Hong Kingston's book The Woman Warrior, and a character named Kwan Gung, the god of the writers, warriors, and prostitutes from Frank Chin's play Gee, Pop. I thought it was interesting to try to bring these two characters together in Torrance, California, in the same way that Stoppard took Rosencrantz and Guildenstern from Hamlet and made another play out of it, bringing about a certain cross-fertilization. At the same time I became very interested in trying to create a form which would make sense, in terms of this new content. At the time my choice was to create some kind of fusion of Asian and Western theater.


The article, based on an extensive literary and artistic material, is devoted to the study of the personaland group exhibitions of the first Georgian modernists. This research helps to understand new processes that took place in the visual art of Georgia in the 1910–1920s. It demonstrates that exhibitions, cultural and artistic activities had a huge impact on the visual culture of Georgia in the 1910s, the period of Independence (1918–1921) and the decades to come. Particular attention is paid to the first public exhibitions of Georgian modernists in multicultural Tiflis. In the early 1910s Tiflis turned into a zone of creative experiment, where new aesthetic ideas of the most radical kind were born. The article outlines the role and significance of Russian and Georgian futurists, who "discovered" the art of Niko Pirosmani in 1912 and organized his firs texhibitions. Leaders of the "left art" in Georgia were brothers Kirill and Ilya Zdanevich. The very first public exhibitions of Georgian modernists were in private apartments, halls or spontaneously assembled shows inartistic cafes. These exhibitions reflected two issues that were of major importance for the young Georgian artists — they wished to become a part of the European culture and to preserve their national identity.


Effect of nutrient solution hypoxia stress on growth index,photosynthesis of muskmelon seedlings were studied in this paper.The results showed that under hypoxia stress the growth of the seedlings were inhibited;the growth index such as fresh weight,dry weight and chlorophyll content,net photosynthesis and transpiration rate were all obviously decreased.But the number of advantious roots and root activity were all distinctly increased under hypoxia stress.The contents of MDA,H2O2 were obviously enhanced,but at the same time the contents of soluble sugar,amino acid,free polyamines and heat-stable protein were all dramatically increased.The growth rate,the rate of photosynthesis,root activity and content of metabolite of Xingguang were higher,which alleviated the harm of hypoxia stress to seedlings.As a result the growth of Xingguang seedlings was better than that of Xiyu 1.


INTRODUCTION: Intravenous access in cancer patients is a matter of vital importance. In particular, central venous pressure monitoring, intravenous chemotherapy, multiple antimicrobial treatment, laboratory review of blood sample, long-term nutrition, blood and blood product transfusion as a convenience for such operations are often needed. However, in this group of patients, the central venous catheterization attempt involves a serious complication risk. Catheter-related infections and bleeding problems are a major problem in this group of patients. The decision and management of the central venous catheter is important for patients with haematological malignancies. In this study, we aimed to investigate the use of Central venous catheter interventions in hematologic malignancies patients who have followed anaesthesia intensive care unit in the last year and retrospectively in terms of the complication rate of our choice in the region. METHODS: In one year, 40 patients with haematological malignancies with a central venous catheter were retrospectively evaluated. The patients were examined in terms of location, bleeding, catheter infection and the day of the catheterization. The data were analysed with SPSS 24.0 version on a personal computer. RESULTS: 16 of the implanted catheters were preferred as internal jugular vein/subclavian vein (40%) and 24 as femoral vein (60%). Three of the implanted catheters were associated with catheter infection, the placement of these catheters was a non-femoral attempt. A patient with a non-femoral procedure had bleeding complication. Orijinal Çalışma 425 Adress for correspondence: Arif Timuroğlu, Dr. Abdurrahman Yurtaslan Ankara Onkoloji Eğit. ve Araş. Hastanesi Ankara, Türkiye e-mail: email@example.com Available at www.actaoncologicaturcica.com Copyright ©Ankara Onkoloji Hastanesi The mean duration of the femoral catheters was 5.8 days and the mean duration of the catheters placed from the internal jugular vein/subclavian vein was 9.3 days. DISCUSSION and CONCLUSION: In patients with hematologic malignancy and intensive care indications, we recommend that femoral catheterization be safely chosen in terms of infection if the required asepsis rules are followed, and subclavian or internal juguler vene should be recommended when appropriate conditions are established for haemostasis.


Abstract : There are two main components of the work performed during this project. First, a finite-rate vibrational energy relaxation model was developed to study how the possible presence of water vapor in the Tunnel 9 facility could affect the flow properties. We find that water vapor levels at about 500 parts per million (ppm) could cause appreciable relaxation of the nitrogen test gas, however, even at these large levels, the effect on the flow quality is minimal. Secondly, a novel grid generation scheme for hypersonic nozzle flows is presented. The grid is based on the characteristic lines of the supersonic regions of the flow. This allows for grid alignment and clustering along shock waves present in the flow. Results from simulations run on the AEDC Hypervelocity Tunnel 9 Mach 14 nozzle give good agreement with simulations performed using a conventional grid. Some results from an investigation into the effect of wall contour discontinuities present in the Mach 14 Nozzle are presented. Avenues for future research into flow irregularities in the Mach 14 nozzle are outlined.


Block copolymers have the capacity to self-organize into a myriad of aggregate structures when placed in selective solvents, offering great promise for the construction of delivery vehicles and complex nanoscale assemblies. A key feature of these materials is their propensity to become kinetically trapped in nonequilibrium states, meaning that the structures they adopt depend sensitively on the processing route taken. While this makes it challenging to fully explore the landscape of possible morphologies, it also means that careful attention to the pathway of self-assembly can allow for remarkable control over the resulting nonequilibrium structures. In this Perspective, we highlight several recent advances in processing approaches that provide new levels of tailorability to the structures and encapsulated contents of block copolymer assemblies in solution.


Both in its classical single-constraint version and in the multiple one proposed in this paper, preliminary test estimation de facto realizes model selection. Another common model selection procedure is the one based on the Bayesian information criterion (BIC). Using the generic notation from Section 2 and denoting as L (n) θ the likelihood function of the parametric model at hand, this criterion measures suitability of the submodel associated with the constraint θ ∈ ∩j∈JcM(Υj), with c ∈ C, through


The regioselective lithiation-functionalization of 2-arylazetidines has been explored. The nature of the N-substituent is mainly responsible for a regioselectivity switch. ortho-Lithiation occurred, using hexyllithium as a greener base, in N-alkylazetidines, while α-benzylic lithiation has been observed with N-Boc azetidines.


In the automobile steering system, Electrical Power Steering System (EPS) has become the most important steering technology and developing focus depending on its outstanding performances. The basic structures and operation theory of EPS are introduced, and its main characteristics are described in detail. Also, performances and development tendencies of the key EPS technologies are examined.


The design principle and construction of Microcor corrosion monitoring system was introduced in this paper.The detailed operation approach of monitoring was also outlined and the real-time online corrosion status of Wenchang oilfield had been monitored by using this instrument. Experiment results showed that small fluctuated phenomenon appeared in the measured corrosion rate curve at the primary stage,and then the corrosion rate curve tended to be smooth and stable. The Microcor corrosion monitoring system,as a piece of new instrument,has been successfully applied in corrosion monitoring for oilfield production process at Wenchang oilfield,which provided a new means of fast monitoring and evaluation for establishing measures for corrosion prevention of oilfields.


where Ω ⊂ RN (N ≥ 3) is a bounded domain with smooth boundary having certain symmetries (to be specified below), λ > 0, a ≥ 0, are constants, ν is the unit outer normal to ∂Ω, 2∗ = 2N/(N − 2) and 2 < q < 2N/(N − 2). Certain physical as well as biological situations have been modeled by such boundary value problems. We refer to [9], for such applications. Much progress on the existence and qualitative behaviour of solutions for (1.1) with a = 0 has been made in the last few years. To state the results, we define the energy functional associated with (1.1):


In this paper, we show the processes carried out and results of a geophysical characterization of pore types in Jurassic and Cretaceous carbonates in the TS oil field, Gulf of Mexico. In order to make predictions, we carried out a physically consistent petrophysical evaluation and used borehole image interpretation, core analysis and thin section observations. This information was used in the construction of rock physics models that consider various arrangements of pore shape and fracture concentration. After testing the predictability power of our rock physics models, we obtained, by rock physics inversion, the prevalence of various pore types and fracture concentration within the intervals of interest. Once the physical links between the micro structural properties (type and shape of the pores) and elastic properties were established, we proceeded to make connections with attributes obtained by seismic inversion processes. These connections were formed using deterministic and probabilistic approaches where the results are volumes of intercrystalline porosity, dissolution porosity and fracture porosity.


This paper aims at discussing the implementation of simulation systems for SNN based on analog computation cores (neuromimetic ICs). Such systems are an alternative to completely digital solutions for the simulation of spiking neurons or neural networks. Design principles for the neuromimetic ICs and the hosting systems are presented together with their features and performances. The authors summarize the existing architectures and neuron models used in such systems, when configured as stand-alone tools for simulating ANN or together with a neurophysiology set-up to study hybrid living artificial neural networks. As a primary illustration, the authors present results from one of the platforms: hardware simulations of single neurons and adaptive neural networks modeled using the Hodgkin-Huxley formalism for point neurons and spike-timing dependent plasticity algorithms for the network adaptation. Additional examples are detailed in the other papers of the session.