In 1982, Raufman et al. I showed that the venom of the venomous lizards Heloderma suspecturn and Heloderma horridum caused an increase in amylase secretion from dispersed acini of guinea pig pancreas. This effect was attributed to a thermostable peptide structurally related but distinct from VIP on the basis of the following arguments: As for VIP, the venom efficacy on amylase secretion and cyclic AMP production was increased by theophylline; the venom did not alter calcium outflux but potentiated the enzyme secretion caused by secretagogues that mobilized calcium; the venom totally inhibited [ '*'I]VIP binding; the venom effects were inhibited by (Gln9)-~~retin5_27, an inhibitor of both secretin and VIP receptors. At variance with VIP, the venom was unable to interact with a VIP-specific antiserum. The presence in the venom of both lizards of a VIP-like peptide was further substantiated by Amiranoff et al. * who demonstrated an inhibition of the binding of [ "'I]VIP to human and rat intestinal epithelial cell membranes and an activation, in the presence of GTP, of the adenylate cyclase system. In 1984, Gillet et al. in our laboratory described the activation of adenylate cyclase in rat pancreatic plasma membranes by the two venoms and obtained evidence, based on the use of competitive inhibitors of secretin action, that this effect could be mediated through interaction with secretin-prefemng receptors. The purification of the VIP-secretin-like material present in the venom of Heloderma suspectum was undertaken independently by Pisano's group at the National Institutes of Health (USA) and by our group in Brussels. The purification of the active material was monitored by the capability of the material to stimulate amylase production by isolated guinea pig pancreatic acini (Pisano's group) or to activate adenylate cyclase in rat pancreatic plasma membranes (our group). In January 1984, we published4 the isolation and purification to homogeneity of a 5.9-kDa peptide that interacted with VIP and secretin receptors in several mammalian tissues' and was called helodermin. A sample of this essentially pure peptide was sent to Dr. N. Yanaihara (Shizuoka, Japan) who published the complete amino acid sequence of helodermin in December


The synthesis of l-deaza-8-azaguanine has been accomplished via a facile route from pyridine precursors. The site of rihosylation and anomeric configuration of l-deaza-8-azaguanosine and several closely related derivatives was accomplished by cmr and pmr, respectively.


While the rates of new cases and deaths for high grade serous ovarian cancer (HGSC) have declined steadily in the past decade, HGSC remains the fifth leading cause of cancer death in women. As many patients succumb to chemoresistance, there is a need to uncover novel targeted drugs. One way to do so is by drug repurposing. A computational screen, DrugPredict, led to the discovery that amiodarone, an antiarrhythmic, is a potent apoptosis-inducer and Myc-degrader in numerous patient-derived ovarian cancer cell lines. In search of a more selective, but less toxic compound, structure-activity relationship was applied to identify DL78. Due to its structural differences, DL78 is considered to be independent of amiodarone. DL78 lacks hERG activity, retains Myc regulation, and gains selective anticancer properties. This compound produces significant cell death selectively in patient-derived HGSC cells, including isogenic cisplatin-resistant lines, but does not harm non-transformed fallopian tube cells. Cancer cells treated with DL78 arrest prior to anaphase and showcase microtubule abnormalities and upregulation of mitotic regulators. The prolonged arrest leads to loss of Myc, mitotic catastrophe, and apoptosis selectively in the HGSC cells, while fallopian tube cells can cycle normally. DL78's activity is confirmed to be dependent on Myc expression because targeted inhibition of Myc decreases its potency and prevents the DL78-induced cell cycle arrest. Finally, pharmacokinetic analysis shows that DL78 saturates the tumor following intraperitoneal injection, yet drug concentrations in the blood and liver present at normal levels. Overall, these phenotypes do not show with amiodarone treatment, suggesting that structurally different DL78 performs through a different mechanism. Further classification of this tumor-selective compound may reveal targeted ovarian cancer vulnerabilities.
 Citation Format: Jessica Teitel, Michele Cusato, Margaret Farah, Agharnan Gandhi, Pil Lee, Andrew White, John Takyi-Williams, Bo Wen, Andre Monterio Da Rocha, Analisa DiFeo. Novel Myc-dependent compound DL78 selectively induces mitotic catastrophe and cell death in high grade serous ovarian cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 1570.


Dingling,a writer who is good at describing and making female images,has paid a lot attention to the fate of female in his earlier short stories.Female images in four of her short stories are demonstrated and analyzed to present her writing style.


The optimisation of Technical Trading parameters is a computationally intensive exercise. Models comprising a modest number of Technical Indicators require many thousands of simulations to be executed over a sample period of data, with the best performing sets of parameters employed to generate future trading signals. The purpose of this research is to investigate the suitability of GPU Computing for running the simulations in parallel and to develop a working Prototype optimiser based on the CUDA architecture. The cumulative nature of Profit and Loss over a sample period is a restricting factor in the design of a data-parallel trading simulator. Thus, different approaches to the distribution of the parallel workload are researched and an appropriate design for the Prototype is derived. Past studies are examined, including parallel Genetic Programming implementations. The remarkable speedups enjoyed by the Prototype are discussed in detail and a number of key design strategies are proposed. These include a per-thread solution identification methodology, a modification to Welford's Standard Deviation algorithm which results in the avoidance of divergent threads, and a suitable parameter distribution policy.


Due to the disturbances in the tourism industry, the Covid-19 pandemic precipitated a wave of economic recession around the world. Consequently, many airlines change their operation portfolio to control costs and maintain market competitiveness. This paper examines the changes in SIA's fuel hedging strategy during this disaster and the gains and losses it generated to the group. The group's background, financial state and share price serve as the foundation for analysis. Furthermore, the paper further examines the possible future changes in SIA's fuel hedging strategy based on the group's recovery from the disaster and adjustments to the group's business strategy.


This paper introduces a dynamic neural network based technique to predict the urban growth in Sriperumbudur taluk, India. The novelty of this technique is integration of neural network and theory of evidence to predict future growth which does not require any definition of input parameters, spatial rules or large dataset that involves expert knowledge and time consuming manual work for preparation. First, Land Use Land Cover (LULC) images were obtained by classifying LANDSAT TM satellite image of 30m spatial resolution captured in the year 1991, 2000 and 2009. Multi-Layer-Perceptron (MLP) neural network is used as a classifier. Second, five spatial metrics namely Shannon's entropy, aggregation index, density, nuclearity, and proximity are derived around each non-urban pixel in 2009 by considering 7x7 window of spatial unit in the LULC images of the three years. Next, these metrics are fed to Focused Time Delay Neural Network (FTDNN) and the metrics for year 2018 are predicted. Finally, evidence pooling is applied to the predicted metrics to identify whether the non-urban pixels in 2009 changes to urban pixel in the year. The predicted results shows that 12.5% of nonurban LULC mainly agriculture and wasteland in 2009 will change to urban land use in 2018. In order to test the performance of the proposed technique, urban land use in 2009 is predicted using LULC images of 1991 and 2000 and compared with actual pixels transformed to urban land use in 2009 from 2000. The predicted result is found to be 81.28 % accurate with spatial autocorrelation of 0.90. The proposed method is also compared with conventional model SLEUTH and found to be 2.56 % more accurate with 0.19 increases in spatial correlation. The results potentially help the city planners and developers to have prior visualization of future urban sprawl in the study area for effective city planning.


The prototype detector of LHAASO-WCDA experiment has found a two-peak structure in the distribution of PMT signals, yielded by near vertical cosmic muons in the water. A full Monte Carlo simulation, showing a very consistent result, verified that a proper measurement has been made. With the help of simulations, the mechanism for the origin of the second peak, produced by muons hit directly on the PMT, is well understood now. As a by-product, a method for the online charge calibration, making use of the second peak of muon signals, is proposed for the future WCDA experiment. Simulations indicate that this way of calibration can provide a precision of a few percents on the charge measurement. A dedicated calibration system based on this method has been implemented on the engineering array of WCDA, and its experimental performance is expected to be given soon.


Employees have feelings, attitudes, values, moods and emotions which when directed in the desired manner leads to organizational effectiveness. One of the foremost contributions of a manger is leadership, because all organizations thrive on human resource as a vital factor. Success of a leader or ability to undertake risk management is an epitome of organization and its behavior, characterized by the leader, group and structure. Organizational environment thus created has evolved a dynamic condition which has given rise to a relatively innovative concept "Responsible leadership" considering maturity level of the group. This is not a theoretical framework but an approach to leadership. Responsible leadership advances the existing definitions of leadership and this research proposes to analyze the impact on organizational behavior.


Detection of AmpC β-lactamases (AmpC-bls) is important for infection control purposes and therapeutic options. Here, we provided a diagnostic anti β-lactamase neutralization test (bla-NT); modified from broth microdilution (BM) for the detection of bls-AmpC, CMY, in multidrug resistant Escherichia coli and Klebsiella pneumoniae . Anti-bla neutralizing activity against these two bacteria was tested. Anti bla-CMY was prepared in rabbits and used in: bla-NT; investigating effect on bacterial colony forming unit (CFU); and in ELISA. In bla-NT, the anti-bla-CMY neutralized exocellular bls produced by the tested bacterial strains and resulted in an increase in the bacterial sensitivity to the tested antimicrobials and reduction in minimum inhibitory concentration. Interestingly, the anti-bla-CMY decreased the CFU and its morphology when added to the tested bacteria. ELISA-OD was significantly correlated with the drop in minimum inhibitory concentration and CFU counts at P-value ≤ 0.05 and 0.01, respectively. It could be concluded that, bla-NT could detect bls-AmpC and run parallel to BM in microbiology laboratory. Investigations are running to develop the test for quantitative detection of bls-AmpC.


OBJECTIVES
To increase awareness in pathology residents of different career choices and familiarize them with the job market.

METHODS
For 3 years, community pathologists and faculty members participated in half-day panels that residents attended voluntarily. Panelists presented their professional life experiences and shared advice. We showcase the implementation and resident evaluation of these panels.

RESULTS
Panelists were rated as outstanding or excellent for relevance. Residents chose the following themes as most useful: visualizing the array of practices (community, part-time, public health, and others), careers that follow unexpected courses and people taking advantage of opportunities as they happen, knowing that not having a definitive direction is frequent, and finding out what different practices look for when they are hiring.

CONCLUSIONS
Career planning is a neglected aspect of pathology residency training, and panels in which pathologists present their experiences are helpful to prepare residents for what lies ahead.


In addition, it was raised that the Ponceau S stained control gel shown in Figure 6B is highly similar to a Ponceau S panel shown in Figure 2B of another article by this research group [2]. The authors indicated that images were assembled inappropriately during preparation of Figures 4B, 5B, and 5E. They also confirmed that Figure 6B involves a duplication of the Ponceau S-stained control band from their previous article [2]. The authors did not provide comments regarding Figures 2 or 6D, and they noted that original blots and gels for the abovementioned figures are unavailable. In light of these concerns, the authors and editors retract this article. The authors apologize to the scientific community for the errors published in this article. The journal editors notified representatives at INRA and CNRS of this matter, and contacted all co-authors about this retraction. SR made the initial request for retraction; SR, DR, DM, LN, MR agreed with the retraction; JC, IA, CP did not respond.


Objective To observe the distribution of CD4(superscript +)Foxp3(superscript +) regulatory T cells (CD4(superscript +)Foxp3(superscript +) Treg) and the subsets in CD4(superscript +)T cells in peripheral blood of adults with minimal change disease (MCD), and explore the significance of CD4(superscript +)Foxp3(superscript +) Treg in the pathogenesis of MCD. Methods Twenty-seven adults with MCD initially diagnosed by renal biopsy were selected. The antibody combination of Foxp3-FITC/CD45RA-PE/CD3-ECD/CD4-PC7 was adopted and flow cytometry was employed to determine the percentage of CD4(superscript +)Foxp3(superscript +) Treg and the subsets in CD4(superscript +)T cells in peripheral mononuclear cells (PBMCs). The expression of Foxp3, RORc, TGF-β1, IL-6, IL-17A and IL-23 mRNA in PBMCs was detected by Real-Time PCR. Besides, normal controls were established. Results Flow cytometry revealed that CD4(superscript +)Foxp3(superscript +) Treg were divided into three subsets: CD45RA(superscript +)Foxp3(superscript low) cells(Fr. Ⅰ, resting Treg), CD45RA-Foxp3(superscript high) cells (Fr. Ⅱ, active Treg) and CD45RA(superscript -)Foxp3(superscript low)cells (Fr. Ⅲ). The percentages of cells of Fr. Ⅰ+Fr. Ⅱ and cells of Fr. Ⅱ in CD4(superscript +) T cells in MCD group were significantly lower than those in control group (P<0.01). The expression of Foxp3 mRNA in PBMCs in MCD group was significantly lower than that in control group (P<0.05), while the expression of RORc mRNA in PBMCs in MCD group was significantly higher than that in control group (P<0.05), and the expression of IL-6, IL-17A and IL-23 mRNA was significantly higher than that in control group (P<0.05, P<0.01). Correlation analysis revealed that the expression of IL-17A mRNA was negatively related to the percentage of cells of Fr. Ⅱ in CD4(superscript +)T cells in MCD group (r=-0.81, P<0.05). Conclusion In adults with MCD, there is decreased expression of Treg and active Treg subsets and increased expression of Th17-related gene and cytokines in peripheral blood, which suggests that the down-regulated expression of Treg Foxp3 mRNA and Treg/Th17 imbalance might be involved in the pathogenesis of MCD.


0.78-1.0 /spl mu/m wavelength tunable femtosecond soliton pulse generation using photonic crystal fibers and fiber laser is demonstrated. Novel pulse trapping phenomena by soliton pulse are discovered and 1 THz ultrafast all optical switching is demonstrated.


Environmental damage due to the discharge of organic pollutants and heavy metal toxins has become a major topic of concern for the past couple of years. Using just a natural adsorbent to solve wastewater concerns has lately gained popularity as an ecologically acceptable solution that encourages long-term growth. A range of approaches, including adsorption to the surface of agricultural leftovers, have been used to minimize heavy metals in an aqueous medium. Lead is amongst the most hazardous and widely discovered toxic substances in industrial waste. Citrus limetta peel powder, Banana peel powder, and Betel leaf powder were chosen as adsorbents in this study to absorb synthetic lead from an aqueous solution since they are low-cost materials. Our research aims to find natural bio-sorbents that can remove highly hazardous Pb2+ ions from aqueous solutions. The importance of contact time, concentrations, adsorbent-based dose, and pH in the adsorption process is investigated. The adsorption rate for betel leaves, Citrus limetta peel, and banana peel was 5, 10, 15, 20, and 25 g.L-1. Citrus limetta peel (10 g.L-1), banana peel (5 g.L-1), and betel leaf (5 g.L-1) provide the highest lead adsorption. Material characterization is used to determine the lead nitrate process in lead adsorption. The capacity of the lead-adsorbing substances to achieve adsorption equilibrium was assessed and estimated using linear Freundlich and Langmuir isotherms, with the experimental data fitting the Freundlich isotherm models.


This paper focused on research of bending properties of a quasi-isotropic strands under made from Re BCO coated conductor( CC) at 77 K,self-field. Firstly,the paper presented the geometrical structure of quasi-isotropic strands. Its critical current was analyzed under circumstance of bending in different regions of the strand. With establishing the geometric deformable model considering in-plane-bending of one single tape,experiments with in-plane-bending of one single tape was performed to measure the critical current Icin order to analyze its attenuation situation. Subsequently,experiments on bending the quasi-isotropic strands with different bending radius were carried out to measure its critical current. Finally,the minimum bending radius of the strands was determined. It is predicted that the strand can have potential application in transmission lines and large-scale magnets.


The Americans with Disabilities Act (ADA) was signed into law in 1990 by President Bush. Although the ADA includes laws about public access rights for people with disabilities and their service animals, many schools are reluctant to have service animals (that are partnered with children with disabilities) included in early childhood classrooms. Teachers that have had experience with working animals in their elementary classrooms have reported many benefits, not only for the student with a disability, but for the other students in the classroom as well. Research on dogs in classrooms has shown potential social, behavioral, and academic improvements in students. However, many parents ofchildren with service animals have reported facing significant challenges when attempting to integrate their child's service animal into their classroom environment. The purpose of this study is to examine the experiences of early childhood educators who have had or who may have service animals in their classrooms. 3 SERVICE ANIMALS IN ELEMENTARY CLASSROOMS Americans with Disabilities Act On July 26th, 1990 the Americans with Disabilities Act was signed into law by President George H.W. Bush. The purpose of ADA is to ensure that persons with disabilities have the same rights and opportunities as every other American. ADA is defined as a civil law that "prohibits discrimination and guarantees that people with disabilities have the same opportunities as everyone else to participate in the mainstream of American life -to enjoy employment opportunities, to purchase goods and services, and to participate in State and local government programs and services" (ADA.gov website). In 2010 and 2011, ADA was further revised to include specific final regulations regarding service animals. Originally under ADA any trained animal that provided assistance to an individual with a disability was considered a service animal and allowed public access rights ("Commonly asked," 2008). However, beginning March 15, 2011 ADA revised the definition of a service animal to only recognize dogs as service animals (U.S Department ofJustice, 2011). Although much of American society associates the term service dog with guide dogs for the blind, service animals can provide a wide range of tasks for their handler. Examples of tasks include, but are not limited to, retrieval work for individuals in need of mobility assistance, alerting individuals who are deafor hard of hearing to sounds, alerting an individual with allergies to the presence of an allergen, assisting an individual during a seizure, providing physical support for individuals in need ofmobility assistance, disrupting behaviors or helping persons with psychiatric and neurological disabilities by preventing harmful behaviors (U.S. Department ofJustice, 2012). 4 SERVICE ANIMALS IN ELEMENTARY CLASSROOMS Emotional Support Animals, Service Dogs, and Therapy Dogs Many Americans confuse the terms Emotional Support Animals, Therapy Dogs, and Service Animals. Emotional support animals and therapy dogs differ from service dogs as they are not trained in any specific task, and only provide comfort to an individual by being with that person ("Frequently asked," 2015). Most emotional support dogs provide comfort to a specific partner, while most therapy dogs are utilized to provide comfort to other individuals, often people other than their owner. Often times ESA's are confused with psychiatric service animals. According to ADA. if a dog has been trained to sense an anxiety attack and take specific action to prevent or lessen its impact then it is qualified as a service animal. However, if merely the dog's presence provides comfort and it performs no specific task to aid the handler, then it is not considered a service animal ("Frequently asked," 2015). It is important to note that therapy animals as well as ESAs do not have public access rights. However, under the Fair Housing Act and section 504, housing providers must make reasonable accommodations for any person with a disability with an assistance animal, including an ESA (U.S. Department of Housing and Urban Development, 2013). Should a person have a disability which requires a service animal or an ESA, the housing provider must make an exception to any pet restrictions unless the specific animal poses a threat to the health and safety of others that cannot be reduced or eliminated by other accommodations, or if the specific animal would cause substantial physical damage to another's property (U.S. Department of Housing and Urban Development, 2013).


XP=Xeroderma pigmentosum being a highly cancer-predisposing disease, this syndrome was the first example in man of a direct association between the presence of unrepaired DNA lesions and cancer development. In this way, DNA repair genes can even be considered as anti-oncogenes or tumour prevention genes. However, this elegant and rational relationship between DNA repair deficiency and cancer proneness has recently been destroyed by the description and biochemical analysis of two other UV-sensitive syndromes: Cockayne's syndrome (CS) and trichothiodystrophy (TTD)


Average adults spend a third of their living in offices, making them susceptible to extreme stress. Often this stress breaks the tolerance threshold and causes deteriorating effects on an individual's mental, physical, and emotional life. This effect is known as Burnout. In medical terms, Burnout is a psychiatric syndrome in response to chronic stress at work. This paper discusses the causes, mitigating factors, and various models of burnout. Also discuss the implications of this phenomenon due to its high relevancy and presence in our 21st-century work culture, where people are seriously overworked and exhausted. Burnout often stays disguised and can reduce a person's wellbeing and productivity over time, not to mention causing chronic health issues, hence it is important to be aware and recognize this before it gets too late.


Abstract 553 Myelodysplastic syndromes (MDS) are stem cell disorders characterized by ineffective hematopoiesis with increased levels of hematopoietic cell apoptosis. Recent discoveries by our group and others suggest that perturbations in pre-mRNA splicing may play a role in MDS pathogenesis. Indeed, more than half of all MDS patients have a mutation in one of eight splicing factors. U2AF1 (U2AF35), a gene encoding a splicing factor involved in intronic 39-splice site recognition, is mutated in 8.7% of MDS patients. The consequence of the highly recurrent serine to phenylalanine mutation at position 34 (S34F) of U2AF1 in hematopoiesis is unknown. Therefore, to examine the effects of mutant U2AF1(S34F) on hematopoiesis, we utilized the MSCV-IRES-GFP retroviral system to introduce mutant U2AF1(S34F) or wild type U2AF1(WT), or an empty vector control, into mouse bone marrow cells for in vitro and in vivo studies. Expression of U2AF1(S34F) results in reduced expansion of transduced bone marrow cells (marked by GFP) compared to both U2AF1(WT) or empty vector-transduced cells grown in suspension culture (2 vs 4-fold change, respectively; p To overcome some of the limitations of retroviral models, we created a single-copy, doxycycline-inducible U2AF1(S34F) transgenic mouse to model the effect of U2AF1(S34F) expression on hematopoiesis. As a control for U2AF1 protein overexpression, we created an additional single-copy, doxycycline-inducible U2AF1(WT) transgenic mouse with transgene integration into the same locus as the U2AF1(S34F) mouse. Induction of U2AF1(S34F) transgene expression in bone marrow cells in culture with doxycycline treatment (200 ng/ml for 5 days) resulted in reduced cell numbers when compared to uninduced U2AF1(S34F) transgenic cells (ratio of growth of induced/uninduced cells = 0.38), while cell proliferation was not altered for U2AF1(WT) transgenic cells (ratio of growth of induced/uninduced cells = 1.13) (p Disclosures: No relevant conflicts of interest to declare.


Twenty‐two stages of the prenatal development of the domestic cat are described for intraspecies comparison in embryological studies. These are assigned to the 15 embryonal periods based on the Nomina Embryologica Veterinaria to make the interspecies comparison possible.


The structural dimension of social capital refers to the overall model,which links enterprises in social network.It includes the presence of networking,strong and weak ties and network structure.This article used the research data of Tianjin and Tangshan area businesses,applied the approach of structural equation model,and studied the influence of structural dimensions of social capital on inter-firm knowledge transfer.The results showed that structural dimensions of social capital have a significantly positive effect on knowledge transfer.


The results of a numerical simulation of the macroscopic behavior in axial compression of concrete cylindrical specimens were presented. According with the results of previous works [1, 2, 3, 4], the introduced constitutive law was a monotonically increasing one. Stresses and displacements fields were evaluated by discrete formulation of the elastic equilibrium problem. When the Mohr/Coulomb cracking criterion was verified, the cylinder geometry was modified with the introduction of new free surfaces due to crack propagation. The macroscopic result in terms of load-displacement was affected by the decreasing of stiffness due to crack propagation. It was showed that the softening behavior is a macroscopic effect bonded to the structural behavior and that it doesn't correspond to a material constitutive property.


Abstract : Each year the Army expends resources processing a large number of applicants in order to recruit the desired number of enlistments. This paper examines the processing of applicants from the Military Enlistment Processing Site through to accession. The differential behavior of various categories of applicants was analyzed over FY 81 and FY 82 to identify patterns, trends, and areas where processing improvements may be possible. Keywords: Enlistment decision making, Recruiting, Enlistment processing, Leadership, Promotion (Advancement), Jobs.


Objective: To investigate the change of CD4 ,CD8, survival rate and hepatic function of xenogeneic encapsulated hepatocytes intraspleen transplantation (XHT) in the treatment of toxic hepatic failure (THF) in SD rat. Methods: Twenty SD rats received intraspleen grafts of 1.5×10 7guinea pig encapsulation hepatocytes by alginate-barium at 48h after D-glactosamine (D-GI) introperitonear injection(19.5mg/kg).Guinea pig free hepatocytes transplantation(1.5×10 7) or 1.2ml injection (FHT n=20 ) and N.S injection 1.2ml (N.S n=20 ) was belonged to control groups. The results of CD4, CD8, survival rate and hepatic function were carried out at 14 days after transplantation. Results: There wasa significant difference in survival rate at 14 days between XHT group (80%), THF group (70%), and N.S group (25%) (P0.05 V P0.01).Up to 14 days, In the XHT group , total bilirubin was (7.99 ± 0.58)mg/L and ALT was (55±6.7)u. In the N.S group (9.63±0.83) mg/L V 91 ± 8.0 u, In the FHT group (8.9 0 ±0.66 mg/L) V (74±7.1) u. There wasa significant difference between XHF and control groups. (P0.05 V P0.01). CD4,CD8 lymphocytes in the recipient spleens by immunohistochemistry inspected at 12 hr , 72 hr and 14d post -graft respectively. In the XHT group, responsed CD4,CD8 lymphocytes at 72 hr,14d. In the FHT group, There was always masculine. Conclusion: The authors concluded that the survival rate and function of encapsulated xenogenic. hepatocytes were maintained up to 14 days after graft. Cellular immune response participates in the rejection. The immune response can be postponed by XHT.


When I was asked to leave the Whitney Museum after eight years there as curator, it seemed clear that the reasons for which I was fired were the very reasons that might make The New Museum a reality rather than an idea which I had been playing with for years. It was an ideal opportunity to find out to what extent a museum, with living artists as its priority, could be established by people who were not independently wealthy or politically powerful, but who cared about the work that was being made by contemporary artists and about the kind of scholarship and documentation which was needed to support that work.


The purpose of this study is to find out whether the local taxes and retributions have effect on the direct expenditures and special autonomy as a moderation in the districts / cities in Aceh. Data analysis in this study uses multiple linear regression, assigning to test and analyze that effect both simultant ly and partially. To examine the effect of local taxes on direct expenditure, retribution on direct expenditures , special autonomy funds on direct expenditures, To examine the effect otsus funds on the relationship between local taxes and direct Expenditures and the effect of the Special Autonomy Fund on the relationship between retributions and direct expenditure on districts/cities in Aceh. The data was processed with SP SS (Statistical Package For Social Science) 22. The results showed that local taxes have effect on direct expenditure. Retributions have effect on direct expenditure. Special autonomy funds have effect on direct expenditure. Special autonomy funds moderate the effect of local taxes on direct expenditure and special autonomy funds moderate the effect of retributions on direct expenditure in districts/cities governments in Aceh.


Functional studies of the development of the corpus callosum in the cat have shown that an intact callosum during postnatal month 1 is necessary for normal visual development. In vivo tracing techniques have not provided enough information on corpus callosum connectivity to fully evaluate the evidence for a morphological mechanism for the functional effects of neonatal callosum section. However, lipophilic in vitro membrane tracers permit a more detailed search for such evidence because the entire limit of many cells can be labeled simulatanously. To investigate the morphological basis for the observed functional results in cats, the corpus callosum was labeled in vitro with the carbocyanine dye, DiI. Crystals of DiI were placed in the midsagittal callosum in tissue from 2 to 277‐day‐old cats. Tissue was coronally sectioned 3–22 months later. Sections were photographed and reconstructed to show the overall distribution of corpus callosum projections, as well as the locations of individual corpus callosum axons and their presumed terminals.


A detailed characterization of the leakage in semiconductor devices is essential for proper adjustment of the manufacturing process in order to eliminate the leakage. Subsurface punchthrough was determined as the leakage current mechanism in the power vertical double-diffused metal-oxide-semiconductor field-effect-transistor, and the quadratic dependence of the drain current was confirmed for the leakage caused by the punchthrough. A failure analysis revealed a large number of dislocations located in the corners of transistor cells. The majority of the detected dislocations were electrically inactive. Dislocation depth measurement indicated that only a small number of the dislocations penetrated deep into the channel, i.e., penetrated from source area to the boron-doped p- transistor channel. The transistor channel shortening caused by the enhanced phosphorus diffusion along the dislocations was determined as the root cause of the leakage. The diffusion spikes of the phosphorus atoms lengthened the n+ source layer, and the interface of the n+ and p- layer was shifted into the transistor channel at the site of the dislocation. Manufacturing process experiments related to the channel lengthening and the channel doping confirmed the theory of the dislocation-induced channel shortening. The occurrence of dislocations was attributed to the surface stress induced by the improper conditions of oxide growing and plasma etching in the affected regions.


Investigations into the planting geometry of rice facilitating relay cropping at zero tillage and its effects on yield components were carried out at the Agronomic Research Area, University of Agriculture, Faisalabad. The planting geometries comprised of 20 x 20 cm hills, 30 cm apart single rows (30 x 15 cm), 45 cm apart double row strips (15/45 cm), 60 cm apart triple row strips (15/60 cm) and 75 cm apart 4–row strips (15/75 cm), while the varieties included in the experiment were Basmati–385 and Basmati–370. The experiment was laid out in split plot design randomizing the varieties in the main and planting pattern in the sub–plots. Basmati–385 appeared to be early maturing and gave significantly higher paddy yield (35.73 q ha –1 ) than Basmati–370 (28.98 q ha –1 ). The highest paddy yield of 34.42 q/ ha –1 was recorded in plots planted in the pattern of 20 x 20 cm hills against the lowest of 30.66 q ha –1 in plots planted in the pattern of 75 cm apart four row strips. The results further led to the conclusion that rice should preferably be planted in 60 cm apart triple row strips as it not only facilitates relay cropping at zero tillage but also gives total yield/ha comparable to the conventional planting system in 20 x 20 cm/hills which does not permit easy planting of relay crops at zero tillage.


Based on the vital function of LFOC in soil carbon cycle,the effects on soils burned from high-intensity wildfire in different years in the forests of Larix gmelinii were studied. Used a specific gravity separation method to examine dynamics of soil light fraction organic carbon( LFOC) of the soils burned in different years( 2002,2006 and 2008) and the soils unburned. The results showed that there was a significant difference between LFOC of soils burned by fire in different years( P 0. 05) : the LFOC content of soils burned in 2008 increased by 11. 99%; the LFOC content of soils burned in 2006 decreased by 8. 77% and burned in 2002 decreased by 6. 27%. LFOC were not correlated with soil water content,but were significantly correlated with the pH value and the LFOC of soils burned in 2008 were very significant positively correlation( P 0. 05); LFOC were also correlated with soil temperature. The seasonal dynamics of soil light fraction organic carbon within all the sample plots performed and especially more obvious after fire disturbance. The results of study provide basic data for researching the fire disturbance on the Northern forest soil carbon cycle,carbon balance mechanism and the carbon effect of forest ecosystem carbon after fire disturbance.


An entrepreneurial activity is one of the basic elements in reviving the economic situation in any country that desires to develop and rise. In the long run, any economic progress and success in any country depends on creative methods or entrepreneurial actions and activities. Entrepreneurship is one of the factors that directly or indirectly impact the economy of a nation; it plays an important role in shaping a country's economic landscape. The purpose of this study is to review the literature in the field of entrepreneurial orientation, to clarify to what extent entrepreneurial orientation influences financial performance and non-financial performance of the SMEs in Saudi. The focus of the review on entrepreneurial orientation is owing to its importance as a key variable in SMEs in emerging economies. In addition, entrepreneurial orientation is a key ingredient for organizational success and it leads to higher financial performance. Hence, the paper will clarify the interaction between the entrepreneurial orientation and financial, non financial performance of the firms. Moreover, as the concept of entrepreneurial orientation is important in competitive environment, it will be interesting to clarify the effect of entrepreneurial orientation on the performance of SMEs.


Territoriality in birds has stimulated considerable inquiry since the classical work of Howard (1920). Despite the profusion of literature on territorial behavior, our understanding of the factors involved in territory selection and of the relationship between territory quality and mating success is still in its infancy. Attempts to quantify territory features and evaluate their influence on differential mating and breeding success have generally concerned polygynous species. Pairing success has been correlated with two territory characteristics critical to reproductive success: the availability of suitable nesting substrates (Willson 1966, Zimmerman 1971, Martin 1971, Holm 1973) and the abundance of nestling food resources (Verner and Engelsen 1970, Willson 1966). These factors are equally important in monogamous species and should influence territory selection and pair formation. The purpose of the present study was to investigate territoriality in a monogamous species, the Field Sparrow (Spizella pusilla), with the aim of elucidating factors influencing territory quality and mating success. The spatial heterogeneity of the study area vegetation resulted in a diversity of habitats for territory occupation. This provided an appropriate setting in which to evaluate the mechanisms of territory selection and maintenance, factors critical in pair formation and mate fidelity, and the potential of each territory for successful breeding.


Exhaled breath contains endogenous particles (particles in exhaled air, PEx) originating from the respiratory tract lining fluid in small airways and formed during airway closure and re-opening. In COPD the vital capacity is usually decreased, probably due to closed-off airways that may result in less airway opening and less PEx. The objectives of the present study were to evaluate if COPD patients in fact have decreased levels of particles in exhaled air and if the levels were related to lung function. Consecutive COPD patients with moderate or severe, stable, disease (n = 17) attending an outpatient lung clinic were included. Healthy, nonsmoking control subjects (n= 9) served as controls. PEx were sampled using a novel technique, where PEx is collected in a device containing a 3-stage impactor and an optical particle counter. A breathing maneuver allowing for airway closure and re-opening was performed. All subjects completed questionnaires and performed spirometry. The median number and mass of exhaled particles per litre exhaled air were significantly lower (p 3 vs. 34.8 x 10 3 particles/L, and 1.3 vs. 9.4 ng/L, respectively), and were positively correlated to FVC and FEV 1 . The content of surfactant protein A will be quantified. Exhaled particles may be future noninvasive biomarkers to identify and monitor patients with COPD, and may also be used in mechanistic studies.


AbstractSeveral Asian countries have launched initiatives to promote the use of information systems and technology (IS/IT). These initiatives are the subject of this paper which presents information gathered by the United Nations Centre for Regional Development (UNCRD) in its ongoing Research and Training Project on Information Systems for Planning. This paper also focuses on the roles that are being played by central and local governments and universities in encouraging the use of IS/IT.


Purpose

To establish a set of screening scale on the aspiration risk applicable to patients receiving enteral nutrition, determine the threshold of the scale and evaluate the scale's reliability-validity.
Methods

Firstly, the screening scale on the aspiration risk of patients receiving enteral nutrition was mainly formed through literature search, expert brainstorming and consultation. And then a retrospective analysis was undertaken by investigating 484 patients in the intensive care unit of 19 tertiary hospitals around China from May 2019 to June 2019. Reliability-validity test on the screening scale concerning the potential aspiration risk among the vulnerable patients was performed. The items in the scale were assigned with scores through expert evaluation method. At last ROC curve was used to evaluate the diagnosis threshold of such scale.
Results

A screening scale on the aspiration risk of patients receiving enteral nutrition was established, including general conditions of patients, primary disease and the accompanying symptoms, treatment strategies, and et al. The Cronbach's a coefficient, interrater reliability, content validity index interval, and the content validity index of such scale were 0.922, 0.920, 0.812-1.000 and 0.944 respectively. All the items in the scale were presented in the form of scores with a total of 12 points. The ultimate diagnosis threshold, sensitivity and specificity were 8 points, 0.800 and 0.627 respectively.
Conclusion

The screening scale on the aspiration risk of patients receiving enteral nutrition was shown to provided precise evaluation of the potential aspiration risk of such patients with compelling sensitivity and specificity, which deserved more clinical studies to confirm its value in other patient populations in the future.


Fault-tolerant systems can be analyzed by Markov state space approach but for more sophisticated and large systems, there should be some other means to estimate the system parameters. Here we extend the Bounding Theorem, we use it in software developements of ultrareliable computer systems to Fire & Gas systems which is a new approach in their safety parameter calculations.


For evaluating the high or low quality of design scheme of the dike construction better, the paper based on AHP established the design scheme, the system of scheme selection and structure model. And confirmed the best scheme from more factors and the point of view ration and qualitative. The calculate example indicates that AHP provides a practicality and simple way for the design scheme selection.


Advances in pervasive computing, machine learning, and human activity recognition are changing preventive health care. Emerging paradigms, such as Mobile Cyber-Physical System (MCPS) and Just-in-time interventions (JITI), allow patients to take health monitoring, diagnosis, therapy and treatments beyond traditional medical settings. These paradigms empower patients by delivering health care at any place and at any time. MCPS provides the necessary engineering support to enable JITI systems to work in an autonomous way. In this work, we review the recent trends in the design of Mobile Cyber-Physical systems for Just-in-time interventions (MCP-JITI), and the different engineering concepts behind this paradigm. Finally, we discuss a set of necessary requirements or design issues to successfully deploy in real world scenarios. This discussion is driven by the description of the MCP-JITI architecture and the interconnections among its components.


Measurement time-tag error affects the precision of Dual-one-way ranging (DOWR) directly. For DOWR applied in deep-space, which have no access to GPS, autonomous time synchronization method is more valuable. In this paper, a method based on two-way time transfer (TWTT) for time synchronization is introduced, and the requirement of TWTT for DOWR is studied. The theoretic precision of PRN-code-based and carrier-phase-based TWTT is analyzed, which shows the combination of the carrier phase and PRN code phase can provide competent time synchronization for DOWR. The system design of a DOWR prototype system integrated with S-band TWTT system is presented. The experiments based on the system indicate that the proposed method is a potential method of autonomous time synchronization for deep space DOWR applications.


The uninterruptible power system of the present invention, the connection by the control unit 11 of the three uninterruptible power supplies (U1 to U3) in the communication cable (C1, C2) constitutes one of the general control section 13. The general control unit 13, when the bias power supply mode by any one of the operating unit 10 is selected, and interconnecting the three switches (S1), if the inverter power supply mode is selected interconnecting the three switches (S2) thereby. Therefore, before (全) it is not necessary to provide an uninterruptible power supply (U1 to U3) and the operation control unit for operating and controlling separately.


This paper presents an improved variation of Probabilistic Foam Method (PFM) for robot path planning. In PFM, a structure named probabilistic foam, formed by bubbles propagate through the free space from initial configuration to goal as a breadth-first search, obtaining a collision-free path. Although the method is able to obtain a navigable path, it is computationally expensive. We propose a new foam propagation approach inspired on random tree growth from RRT. Results from simulation experiments using 2D and 3D map show benefits with the new method.


In oil field water supply system,produced water is treated at all levels and then delivered to corresponding water-injection stations where it is injected to formation.In the water supply system,flow sheet is implicated,water quality is diversified,produced water in some areas is not matched with reinjection,and the pressure of pipe network is not balanced,which often results that the sewages dispatch will be disorder and the produced water will drain to cause environmental pollution.The mathematical models for different hydraulic elements in the water supply system is sets up.A system simulation model is also set up according to the flow balance of nodes,and two kinds of simulation are carried out based on production practice.The technology has been applied to the water supply system in some oil field and has guided local pipes to be rebuilt,so sewages have been dispatched by simulation.The application shows that the technology can balance the pressure among nodes,make sure sewages run reasonably and all the produced water being injected to formation.It provides a necessary theory for the scientific management in oil production and water supply.


SUMMARY Data on the effects of forests on water supplies under South African conditions are meagre but with local and overseas evidence the detrimental effects in the Natal uplands are deduced. The deductions are not highly reliable but in the greater part of the forestry zone there is only a small range within which afforestation can affect runoff. Some popular misconceptions about the effects of forests are dispelled. The effect of tree-planting on regional water supplies is discussed. It is concluded that afforestation can cause a marked decrease in local runoff. For the scale of future afforestation now considered likely, this effect, seen in relation to the growth of demand for water, is, however, so small that changes in dryland land management to increase runoff are not justified. Funds and energy would be better expended in securing additional water supplies from other sources which must, in any case, be found when existing supplies are no longer adequate.


Bile acids (BAs), major regulators of the gut microbiota, may play an important role in hepatobiliary cancer etiology. However, few epidemiologic studies have comprehensively examined associations between BAs and liver or biliary tract cancer. In the Alpha‐Tocopherol, Beta‐Carotene Cancer Prevention (ATBC) study, we designed 1:1 matched, nested, case–control studies of primary liver cancer (n = 201 cases), fatal liver disease (n = 261 cases), and primary biliary tract cancer (n = 138 cases). Using baseline serum collected ≤30 years before diagnosis or death, we measured concentrations of 15 BAs with liquid chromatography–tandem mass spectrometry. We estimated odds ratios (ORs) and 95% confidence intervals (CIs) using multivariable conditional logistic regression models, adjusted for age, education, diabetes status, smoking, alcohol intake, and body mass index. We accounted for multiple comparisons using a false discovery rate (FDR) correction. Comparing the highest to the lowest quartile, seven BAs were positively associated with liver cancer risk, including taurocholic acid (TCA) (OR, 5.62; 95% CI, 2.74–11.52; Q trend < 0.0001), taurochenodeoxycholic acid (TCDCA) (OR, 4.77; 95% CI, 2.26–10.08; Q trend < 0.0001), and glycocholic acid (GCA) OR, 5.30; 95% CI, 2.41–11.66; Q trend < 0.0001), and 11 were positively associated with fatal liver disease risk, including TCDCA (OR, 9.65; 95% CI, 4.41–21.14; Q trend < 0.0001), TCA (OR, 7.45; 95% CI, 3.70–14.97; Q trend < 0.0001), and GCA (OR, 6.98; 95% CI, 3.32–14.68; Q trend < 0.0001). For biliary tract cancer, associations were generally >1 but not significant after FDR correction. Conjugated BAs were strongly associated with increased risk of liver cancer and fatal liver disease, suggesting mechanistic links between BA metabolism and liver cancer or death from liver disease.


The generation of bioengineered cartilage tissue suitable for transplantation is a potential therapy to treat damaged cartilage. We have shown previously that the physical and biomechanical properties of bioengineered cartilage can be improved by the application of 30 min of cyclic compression by a mechanism involving sequential upregulation of gene and protein levels of membrane type‐1 matrix metalloproteinase (MT1‐MMP) and MMP‐13. In the current study, we demonstrated that MT1‐MMP is critical to this response, as blocking the upregulation of MT1‐MMP prevented the improvement in tissue formation. MT1‐MMP seems to act by inducing tissue remodeling as evidenced by the presence of aggrecan degradation products by Western blot analysis and increased release of matrix molecules into the media. Release of these molecules was diminished when MT1‐MMP upregulation was prevented. This matrix degradation was likely due to MT1‐MMP, as under conditions where MMP‐13 expression is maintained (stimulation in the presence of MT1‐MMP siRNA) the release of these matrix molecules into the media was still prevented. It also appears that MT1‐MMP does not regulate MMP‐13 gene expression, as MT1‐MMP‐siRNA pretreatment had no effect on MMP‐13 expression following mechanical stimulation. Further analysis of the anabolic genes and proteins involved in mechanically stimulated cartilage will lead to better understanding of the mechanism(s) underlying tissue formation yielding improved bioengineered cartilage. © 2010 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 28:921–927, 2010


The purpose of this paper is to present a new approach to an early decision-making for detecting the signal in random noise by focussing our attention on the initial time estimate when the signal to be detected is applied. The problem is mathematically stated within the framework of Ito stochastic calculus. The key notion of early decision-making presented here is an application of the multiple hypothesis testing which leads us to compute the likelihood-ratio function. Aspects of the procedure and numerical experiments are also shown by processing real data.


The plasma enhanced atomic layer deposition process for the HfO2 thin film is modeled as simple reactions between Hf(OH)3NH2 and reactive oxygen species. The density functional theory calculation was performed for plausible reaction pathways to construct the reaction profile. While the triplet molecular oxygen is unlikely to form a reactive complex, the singlet molecular oxygen forms the stable adduct that goes through the transition state and completes the reaction pathway to the products. Either two singlet or two triplet oxygen atoms make the singlet adduct complex, which follows the same pathway to the product as the singlet molecular oxygen reacts.


2D molecular crystals (2DMCs) have attracted considerable attention because of their unique optoelectronic properties and potential applications. Taking advantage of the solution processability of organic semiconductors, solution self‐assembly is considered an effective way to grow large‐area 2DMCs. However, this route is largely blocked because a precise molecular design towards 2DMCs is missing and little is known about the relationship between 2D solution self‐assembly and molecular structure. A "phase separation" molecular design strategy towards 2DMCs is proposed and layer‐by‐layer growth of millimeter‐sized monolayer or few‐layer 2DMCs is realized. High‐performance organic phototransistors are constructed based on the 2DMCs with unprecedented photosensitivity (2.58 × 107), high responsivity (1.91 × 104 A W−1), and high detectivity (4.93 × 1015 Jones). This "phase separation" molecular design strategy provides a guide for the design and synthesis of novel organic semiconductors that self‐assemble into large‐area 2DMCs for advanced organic (opto)electronics.


Aging aircraft may develop multiple-site damage (MSD) that can reduce the structural integrity of fuselage structures. The existence of small cracks emanating from adjacent rivet holes in a fuselage lap-splice joint is of major concern. Small collinear cracks greatly reduce the residual strength of a panel with a lead crack. Recent studies predicting the residual strength of flat and curvilinear panels with riveted lap-splice joints gave encouraging results but some difficulties arose in modeling small cracks at rivet-loaded holes. Thus, there was a need to conduct detailed fracture analyses of the crack-linkup phenomenon in lap-splice joints with rivet-loaded fasteners.


Research on enforcing compliance with the European Union's (EU's) rule of law value has focused on the roles of the European Commission, the European Parliament and the Court of Justice of the EU. However, the Council of the EU has attracted less attention. Existing scholarship has convincingly established that the rotating Presidency can crucially influence the functioning of the Council, and, accordingly, this paper examines the discretionary impact the Presidencies have towards Art.7 procedures. Drawing on official documents and statements, this paper compares how the various Presidencies from 2018 to 2022 have used their privileged position on the Council's agenda to decide whether to move forward with hearings. In doing so, they selected appropriate agenda‐shaping strategies, shaped the Commission's perceived opportunities to exercise its agenda prerogatives, avoided compromises on the trios' agendas and, sometimes, benefited from not dealing with Art.7 to pursue other agenda priorities. The Presidency's wide room for manoeuvre hinders the Council's activity in scrutinising backsliding governments.


THE INVENTION CONCERNS A DEVICE READING WRITING TAPE TYPE WITH A HOUSING WITH HOUSING 100 112 CAPABLE OF RECEIVING A TAPE AND 10 WITH MEANS Reading Recovery SUITABLE TO COOPERATE WITH THIS TAPE. INVENTION MEANS OF DOORS Reading Recovery ARE SUPPORTED BY A SLIDE 130 112 ELASTICALLY IN HOUSING SO THAT WHEN INSERTING THE TAPE IN HOUSING 10 112 HOUSING, CONTACT THE TAPE 10 SLIDE 130 THEN RESULTS IN LIGHT OF SLIDE BACK TO BOTTOM 130 112 HOUSING, TO ENSURE SELF CENTER OF SLIDE 130 TAPE ON 10 AND ENSURING CLOSE PROXIMITY BETWEEN THE MEANS AND TAPE Reading Recovery.


A model of gender-work assimilation is employed to evaluate the structure of male-dominated occupations and the behavior of women employed in these occupations. It is suggested that because certain occupations have been the exclusive domain of males, the masculine sex-role "spilled-over" into the definition of job related tasks. The masculine sex role and work-emergent behavior cause women to act according to the norms of the occupation. With low occupational representation, women choose, or are pressured into choosing, job specialties considered sex appropriate. The author also suggests that the higher proportion of women in the occupation, the less conforming and more individualistic women become in choosing job specialties.


Background: The poppy seeds commonly known as 'khus-khus' or 'postadana', obtained from opium poppy plant (Papaver somniferum L.) is known one of the world's oldest medicinal plant. Its alkaloids, seeds and oil used since time immemorial for therapeutic, food stuffs and economical purpose. An effective breeding program plays an important role for selection, genetic improvement and development of high yielding cultivars/variety in opium poppy. Therefore, a study was conceded out to evaluate the genetic variability, path analysis for different agronomic traits along with their major chemical constituents of opium alkaloids in 30 accessions/landraces of opium poppy (Papaver somniferum L.) collected from different geographical places of India.
 Methods: The 30 genotypes of Opium poppy including different breeding lines and landraces collected from different places were grown in year (2017-18) in randomized complete-block designs (RCBD) with three replications at the research farm of CSIR-Central Institute of Medicinal and Aromatic Plants (CIMAP), Lucknow. Morpho-metric data were recorded on five competitive randomly selected plants in each line for following thirteen traits. Dried husk/straw capsules were chemically analyzed through HPLC. The pooled mean data were statistically analysed by using Windostat statistical software 4.0 versions available at Department of Genetics and Plant Breeding, CSIR-CIMAP Lucknow.
 Result: Variation among the mean of thirty diverse genetic stocks was highly significant (p less than 0.01) for all thirteen traits. High heritability coupled with high Genetic advance as percent mean (GAM) and Genotypic coefficient of variation (GCV) for the traits Thebaine and Nosacapine. The results of associations studies revealed that the trait capsule/plant was positively and significantly correlated with seed (g)yield/plant (gm) and nosacapine at both genotypic and phenotypic level. According to results, a significant genetic variability was also present among 30 accessions, simple selection can be employed to improve seed yield along with alkaloids yield.


This paper analyzes on the objective necessity of constructing the saving-type society in Shanxi Province,points out some key works that should be grasped firmly currently in constructing the saving-type society in Shanxi Province,and puts forward some suggestions on constructing the saving-type society in Shanxi Province.


Aim: Present study includes the development and evaluation of superporous hydrogel composites of acrylamide using starch silicone dioxide coprecipitate (SSC) as composite agent. Methodology: Gas blowing method was used for synthesis of superporous hydrogels. Different ingredients were mixed in specified amount in test tube and foaming agent was added at last. Simultaneous foaming and gelation lead to formation of porous hydrogel networks. Effect of different treatments (acetone dehydration and simulated gastric fluid (SGF) treatment) and drying conditions on the porous structure was evaluated. The prepared superporous hydrogels were evaluated for density, porosity, equilibrium swelling ratio, equilibrium swelling time, mechanical strength, scanning electron microscopy studies. The pure drug (Verapamil Hydrochloride) mixed with Carbopol 934 (1:0.5 and 1:1 ratio) was loaded into the selected batches of SPHC using in situ method of drug loading Original Research Article British Journal of Pharmaceutical Research, 4(3): 338-351, 2014 339 (drug added directly into the reaction mixture). The in vitro drug release was carried out using USP II dissolution apparatus. Results: Acetone dehydrated superporous hydrogel composites were observed as better floating devices due to least density and maximum porosity values. Maximum swelling ratio was found in case of oven dried conventional superporous hydrogel and superporous hydrogel composites with equilibrium swelling time of more than 25 min. On the other hand, acetone dehydrated SPH showed less equilibrium swelling ratio with equilibrium swelling time of 5-10 min. Minimum swelling ratio was observed in case of SGF treated hydrogels with equilibrium swelling time of 15-19 min. Mechanical strength was improved by addition of starch silicone dioxide coprecipitate as composite agent. SGF treatment also leads to enhanced mechanical strengthbut compromised swelling characteristics. SEM images showed uniformity in pore structure in case of acetone dehydrated hydrogels. Acetone dehydrated SPHC showed sustained drug release behavior with 71.14% and 57.84% of verapamil released in 12 h in the batches with Drug: Carbopol 934ratio of (1:0.5 and 1:1) respectively. Conclusion: Acetone dehydrated SPHC were found to be promising formulations with sufficient swelling and mechanical properties for achieving sustained drug delivery.


Holder pasteurization (62.5{degrees}C, 30 min) of human milk (HM) is thought to reduce the risk of transmitting viruses to an infant. Some viruses may be secreted into milk- others may be contaminants. The effect of thermal pasteurization on viruses in HM has yet to be rigorously reviewed. The objective of this study is to characterize the effect of commonly used pasteurization techniques on viruses in HM and non-HM matrices. Databases (MEDLINE, Embase, Web of Science) were searched from inception to April 20th, 2020 for primary research articles assessing the impact of pasteurization on viral load or detection of live virus. Reviews were excluded, as were studies lacking quantitative measurements or those assessing pasteurization as a component of a larger process. Overall, 65,131 reports were identified, and 108 studies included. Pasteurization of HM at a minimum temperature of 56{degrees}C-60{degrees}C is effective at reducing detectable live virus. In cell culture media or plasma, coronaviruses (e.g., SARS-CoV, SARS-CoV-2, MERS) are highly susceptible to heating at [≥]56{degrees}C. Although pasteurization parameters and matrices reported vary, all viruses studied, with the exception of parvoviruses, were susceptible to thermal killing. Future research important for the study of novel viruses should standardize pasteurization protocols and should test viral inactivation using a human milk matrix.


This study compared two teaching pedagogies to address medical emergencies in dental office visits and evaluated dental school students' knowledge about medical emergencies. This randomized controlled trial involved 54 senior undergraduate dental students at the Federal University of Santa Maria divided in two groups: students who received instruction via face-to-face traditional expository class; and students who received the same instruction via distant learning format. The students were randomly allocated to the groups by the randomiser.org website. Data were obtained by comparing the scores students received from answering to a semi-structured questionnaire containing inquiries on ethical and legal implications, and diagnosis and management of medical emergencies in a dental office before and after the instruction. Before the instruction, 96% of students from the two groups lacked knowledge about the ethical and legal implications related to the dentist obligation to deal with medical emergencies. After the instruction, both groups increased their knowledge similarly as there was no significant difference in the comparison between learning about medical emergencies through lectures and thorough an e-learning format. Both teaching methods presented satisfactory results, which makes the e-learning method an option as a didactic strategy. Descriptors: Medical Emergencies. Dentistry. Distance Learning.


The present invention aims to provide a manufacturing method and a wafer lens manufacturing apparatus of a wafer lens which can be easily obtained a highly accurate wafer lens. Method for producing a wafer lens of the present invention is a method for producing a wafer lens in which a lens portion made of light-curing resin on at least one surface of the glass substrate, a negative shape corresponding to the optical surface shape of the lens portion a dispensing step of dropping a photocurable resin into a mold having a surface, after dispensing step, the imprint process imprinting presses the resin and the glass substrate, after the imprint process, light irradiation to the resin an exposure step, after the exposure process, comprising a mold from the glass substrate and a release step of releasing, a dispensing process, pressure reduction at least some of the imprint process, exposure process and the release process.


I believe that we need to be thinking more about influence, Information Operations (IO), and strategic communications as a basis for deterring terrorists and their supporter. Five years ago, I began to examine what was being done in these areas and concluded that there were many good pieces of work underway, both analytical and operational, but many of them were fragmented. Although we talk about seeing and thinking about things from a systems perspective, we often tend not to do that. If we are going to conduct effective, influential information operations or strategic communications, we must consider three elements of the system: cultures—what people in a particular culture believe, what their values are, what motivates them; cognition—the way people actually make decisions; and networks—be they social, complex, or communication networks. Therefore, together with Christine A. R. MacNulty, founding President and CEO of Applied Futures, Inc., has more than 35 years experience as a consultant in longterm strategic planning, technology forecasting, technology assessment, and socio-cultural change. Her clients include The Joint Staff, OSD, USMC, USCG, USA, and NATO. She has applied her knowledge of strategy, culture, and cognition to understanding our adversaries and assessing effective nontraditional operations, information operations, and strategic communications. A prolific writer, she is the author of the Army War College monograph, "Transformation: from the Outside In or the Inside Out?" to be published Fall 2008. She was elected a Fellow of the Royal Society of Arts, Manufactures and Commerce for her contributions to British industry. Her monograph, "Truth, Perception and Consequences" was also published by the Army War College.


Background: Breast cancer is the most commonly diagnosed cancer and the first leading of cancer related deaths among Hispanic women. The use of technologies, such as next generation sequencing (NGS), have led to the discovery of tumor biomarkers that are currently being used to guide personalized treatments to improve overall survival. Although several studies have characterized breast cancer tumors in Caucasian and European patients, a comprehensive genetic profiling of tumors from Puerto Rican Hispanics (PRH) has not been performed. In order to have a better understanding of the tumor biology of breast cancer among PRH, in this study we aimed to characterize the mutational landscape of breast cancer tumors from PRH and compare them to data available from other racial/ethnic groups from the mainland U.S..
 Methods: A retrospective study design with data provided by CARIS Life Sciences was used to: 1) Estimate the prevalence of somatic mutations among breast cancer tumors from 189 Hispanics from PR (PRH) that underwent NGS testing from 2015 to 2020; and 2) Compare the mutation prevalence of PRH tumors with the breast cancer mutational profiles available through the TCGA Pan-Cancer Atlas Clinical Data (TCGA) and the AACR Project Genomics Evidence Neoplasia Information Exchange (GENIE), both databases can be accessed through the cBioPortal for Cancer Genomics. Descriptive statistics were performed to characterize the database.
 Results: Among the top mutated genes for breast cancer tumors among PRH were TP53 (65.9%, n=126), PIK3CA(22.7%, n=141), ARID1A (14.7%, n=68), NF1 (9.4%, n=64), RB1 (9.3%, n=108), PTEN (8.3%, n=133), GATA3 (7.3%, n=137), CDH1 (5.8%, n=139), MAP3K1 (5.6%, N=125), and BRCA2 (5.1%, n=136). The most frequent gene amplification for PRH were ZNF703 (15.0%, n=107), NSD3 (13.9%, n=108), ADGRA2 (12.2%, N=98), FGFR1 (11.2%, N=107), CCND1 (11.1%, n=108), MCL1 (10.2%, N=108), FGF3 (9.7%, N=93), NOTCH2 (9.4%, N=106), FGF4 (9.1%, N=99), FGF19 (8.8%, N=102), DDX5 (6.5%, N=108), EGFR (5.7%, N=106), and ERBB2 (5.6%, N=108).
 Conclusion: This is the first study to report the mutational profile of breast cancer tumors from PRH and to describe the difference in their mutational frequencies when compared other racial/ethnic populations using data from TCGA and GENIE databases. Understanding the somatic mutational landscape of breast cancer in PRH is crucial to guide research efforts in the development of new therapeutic modalities.
 Citation Format: Hilmaris Centeno-Girona, Ingrid Montes-Rodriguez, Harrison Torres-Pagan, Ceciliana Aldarondo-Hernandez, Ediel Rodriguez, Camila Rivera-Lynch, Noridza Rivera, Marcia Cruz-Correa. Interrogating the molecular profile of breast cancer tumors in US Hispanics [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 1172.


The following listing groups varieties according to 1976 California Avocado Society recommendation (1 to 5), private introductions (6 to 8), and University of California patents (9 and 10). Within each group, they are listed in order of palatable maturity. Other new experimental varieties are being tested, both private and UC. A third UC patent, Esther, has mediocre flavor which degenerated to "unacceptable" flavor at the end of the more tropical California summers of 1982 and 1983.


: The physical design and location of the existing Parliament House has influenced the evolution of Australia's parliamentary system. The new Parliament House will exert a new set of influences. The Executive will assume an entrenched position within its own enclave and Ministers will be physically more remote from backbenchers. The physical arrangements of the Executive entrance and the Prime Minister's suite will encourage a presidential-style status in the office. But the architecture also emphasises the public's access to Parliament in the spirit of Burley Griffin's original conception. There is likely to be a strong "congressional" impetus arising from the prominence given to committee room space and backbencher facilities. Tensions between the Executive and Parliament will be exacerbated. Changes to procedures and to parliamentary administration are also likely to flow from the new layout and facilities. The new building will provide an impetus for widespread parliamentary reform.


The chemical heterogeneity of reverse osmosis membrane surface and its impacts on membrane fouling were investigated using dynamic hysteresis, which is a newly developed surface analytical technique. Based on dynamic hysteresis measurements, it has been demonstrated that the chemical heterogeneity of membrane surface was greatly influenced by solution—pH and ionic strength. Significant variation of dynamic hysteresis was observed as solution pH changed, implying the alteration of membrane surface heterogeneity. Interestingly, there existed the interplay between chemical and physical surface heterogeneity with respect to solution ionic strength. At low ionic strength, dynamic hysteresis mostly reflected chemical surface heterogeneity, while physical surface heterogeneity played more dominant role in the change of dynamic hysteresis with increasing ionic strength. This implies that membrane fouling due to chemical surface heterogeneity of the membrane is less remarkable in seawater desalination compared to wastewater and brackish water treatments. In addition, mechanisms and factors affecting chemical and physical surface heterogeneity and their interplay with respect to solution chemistry including pH, ionic strength and divalent cation concentration are discussed and elucidated.


Radiative deexcitation (RD) of the metastable 2S state of muonic protium and deuterium atoms has been observed. In muonic protium, we improve the precision
 on lifetime and population (formation probability) values for the short-lived {\mu}p(2S) component, and give an upper limit for RD of long-lived {\mu}p(2S) atoms. In muonic deuterium at 1 hPa, 3.1 +-0.3 % of all stopped muons form
 {\mu}d(2S) atoms. The short-lived 2S component has a population of 1.35 +0.57 -0.33 % and a lifetime of {\tau}_short({\mu}d) = 138 +32 -34 ns. We see evidence for RD of long-lived {\mu}d(2S) with a lifetime of {\tau}_long({\mu}d)
 = 1.15 +0.75 -0.53 {\mu}s. This is interpreted as formation and decay of excited muonic molecules.


INTRODUCTION
Asthma is one of the most common chronic disease among children, and is considered as a global health problem. According to the guidelines of childhood Asthma, parental education in order to improve their knowledge and self-efficacy should be considered in clinical care. Therefore, this study was performed with the purpose of investigating the influence of multimedia education on knowledge and self-efficacy of the parents of children with Asthma.

METHODS
This study is a clinical trial which was carried out on 50 parents of children with Asthma. Data collection instrument included the demographic questionnaires, assessing knowledge and self-efficacy of the parents of children with Asthma. Reliability and validity of the instruments were assessed and the multimedia education was carried out for the experimental group. Data analysis was done using SPSS 13 and descriptive inferential statistical tests (independent t-test and Mann-Whitney).

RESULTS
History of Asthma was present in majority 52% of the families of the children and 54% reported smoking in their home. The average scores of knowledge and self-efficacy of the study samples in the experimental group showed an increase after multimedia education methods, so that there was a statistically significant difference between the experimental and control groups.

CONCLUSION
The results obtained in this study also demonstrate that educating parents through multimedia technology increase their knowledge and self-efficacy in their care of children.


The invention relates to technology for utilizing vanadium-containing stone coal, in particular to a method for completely recycling the vanadium-containing stone coal. By the method, trivalent vanadium in the stone coal is improved into a pentavalent vanadium product, energy in the stone coal is used for generating electricity, and other solid slag is used for producing building materials such as cement and the like. The technology comprises the following process flows that: the stone coal is combusted and heated by hot air, produced heat is used for oxidizing roasting of vanadium extraction, vanadium oxidation is exothermic reaction, and a large amount of high-temperature flue gas produced after combusting and roasting are finished is used for preheating the stone coal and generating the electricity; the waste heat of roasted clinker is recovered and used for heating combustion-supporting air for combusting the stone coal, and the roasted clinker is subjected to industrially mature vanadium extraction, vanadium precipitation and ignition processes to extract V2O5; and the residual solid slag is used for producing the cement or other building materials. In the process, an additional heat source is not required to be provided for the roasting process with highest energy consumption during the vanadium extraction, and materials and energy in a system for extracting vanadium from the stone coal are furthest recycled, so that the economic value of the stone coal is obviously increased.


Particulate organic matter (POM) is quick and easy for fungi and bacteria to decompose and the C and energy provided readily available. It is biologically active with a short turnover rate. In order to determine soil organic carbon (SOC) and N storage in whole soil (WS) and POM for different levels of cattle and pig manure and to compare their effect on soil nutrient and okra (Abelmoschus esculentus (L.) Moench) growth and yield, a screenhouse experiment was established. The experiment involved sandy loam soil (60% sand, 26% silt, 14% clay) amended with four levels (20, 40, 60 and 80 g kg -1 soil) of pig and cattle manure respectively and a control (0 g kg -1 soil). Seeds of a short duration variety (NHAe 47-4) were planted. Soil samples were collected for chemical analysis and selected plant growth parameters (plant height, number of leaves and stem girth) were monitored at the second, fourth, sixth and eighth weeks after planting. Yield parameters (okra pod weight, length and diameter) were determined at five harvests. Soil samples were analysed for whole soil and particulate organic matter C and N content, whole soil pH, Ca, Mg, K, P and Na were also determined. Data collected were subjected to analysis of variance and means separated using least significant difference (LSD) at p = 0.05. C:N ratio, C and N enrichment were calculated and correlation and regression equation established for whole soil and particulate organic matter C and N. Cattle and pig manure significantly increased WS O.C., pH, P, K, Ca and Na, with the exception of Mg, it also significantly increased okra stem girth, pod weight, pod length and pod diameter with the exception of plant height and number of leaves. Cattle and pig manure also significantly increased POM C and N and POM significantly enriched with WS C and N. Application of cattle and pig manure at 60 g kg -1 was found optimal for soil properties considered. Correlation coefficient between WS C and POM C and between WS N and POM N were all positive, however, the correlation decreased with time in C but increased in N.


Field experiment was carried out at the Research Farm of Korea University, Republic of Korea to study effects of sulfur (S) fertilization on growth traits, yield and yield components of three Korean soybean varieties (Poongsunnamulkong, Saedanbaekkong and Daewonkong). Seeds were sown on black polythene mulched soil bed at the spacing of 15 X 60 cm both at control and sulfur fertilized (gypsum with 16% sulfur content at the rate of 200kg ha-1) plots following a Randomized Complete Block Design of the experiment applying three doses of sulfur together at the time of seed sowing and two doses together at V4 vegetative growth stage (4 nodes on the main stem beginning with the unifoliate node). The results showed that sulfur fertilization significantly increased all studied growth traits of three Soybean varieties except plant height when they all reached physiological maturity stage (120 DAS). It was also evident that sulfur fertilization in the form of gypsum can also increase the number and weight of soybean root nodules and enhance the ability of nitrogen fixation, and so reduce the input of nitrogen fertilizer. Similarly, all the studied yield and yield component related parameters were also significantly influenced by sulfur fertilization except seed number per pod and 100 seed weight. Varieties and sulfur fertilization also interacted significantly in all studied growth traits but the notable sole interaction effect was in plant height. Leaf area of Poongsunnamulkong and Saedanbaekkong variety increased significantly with sulfur fertilization while it was decreased significantly for Daewonkong. Similar trend was observed in their production of number of pods per plant and grain yield per plant indicating leaf area increment by sulfur fertilization played an important role in increasing yield of Poongsunnamulkong and Saedanbaekkong varieties though their performance was reverse in other growth traits. The improvement in growth and yield attributes after sulfur fertilization led to higher biological yield and enhanced seed yield.


This paper, by the head and the deputy head of the Civil Marine Navigational Aids Division of the Admiralty Surface Weapons Establishment, deals with certain problems relating to the proposed Channel Navigation Information Service, including radar coverage, the transmission of information, computer assistance and information display. The paper was read at a meeting of the Institute held in London on 30 January 1974 with the President in the Chair. Much of the background to marine traffic problems in the Dover Strait has already been discussed in previous issues of this Journal. It was decided in 1971 that some radar surveillance of the area would be appropriate. The first steps were taken when a radar trial was conducted by A.S.W.E. in the St. Margaret's Bay area near Dover in 1971. As a result of these trials the Coastguard station at St. Margaret's was fitted with a standard marine radar as an interim solution.


Constraint-solving is an expensive phase for scenario finding tools. It has been widely observed that there is no single "dominant" SAT solver that always wins in every case; instead, the performance of different solvers varies by cases. Some SAT solvers perform particularly well for certain tasks while other solvers perform well for other tasks. In this paper, we propose an approach that uses machine learning techniques to automatically select a SAT solver for one of the widely used scenario finding tools, i.e. Alloy Analyzer, based on the features extracted from a given model. The goal is to choose the best SAT solver for a given model to minimize the expensive constraint solving time. We extract features from three different levels, i.e. the Alloy source code level, the Kodkod formula level and the boolean formula level. The experimental results show that our portfolio approach outperforms the best SAT solver by 30% as well as the baseline approach by 128% where users randomly select a solver for any given model.


Improvement of V2O5-WO3/TiO2 (VWT) supported catalytic sheet filter (SF) has been achieved by using a simple dip coating method with varied concentration of ball milled catalyst coating solution (10-30 wt%) and discussed their NO conversion performances at different reaction temperature (220-380  ̊C). Increase in the catalyst concentration more than 15 wt% it observed the bimodal particle size distribution with the particle size of ~1 micron and >2 micron, which leads to increase in pressure loss of catalyst filter as result to improve the NO conversion performance from 50% (BM10SF) to more than 90% (BM25SF and BM30SF) at reaction temperature range of 260-360  ̊C with Nx leakage less than 50 ppm in the reaction temperature range of 280-340  ̊C. Microstructural study with the help of an optical images explained the surface morphology of the SF with empty and buried (with VWT catalyst) pores. The filtration rate was less than 0.01 m / s, the NO conversion rate of 90% or more was achieved.


Sixteen unmedicated (14 never-medicated, 2 with washout periods of 1-2 weeks) schizophrenic patients displaying positive symptoms (e.g., formal thought disorder, hallucinations, delusions) without negative symptoms (e.g., flattening of affect, loss of energy, anhedonia--type ! patients), 15 umnedicated (with washout periods from 1 week to 2 years) patients with marked negative syn~pfomatology [type H patients; criterion score below 151above 35 on the Munich version of the Scale of Assessment of Negative Symptoms (SANS}, respectively], and 31 matched normal controls were investigated using regional cerebral blood flow [rCBF; dynamic single-photon emission computerized tomography (SPECT) with Xenon-133 as tracer] and magnetic resonance imaging (MRI; spin-echo technique, Tt weighted, midsagittal cuts), rCBF measurements were performed during both resting conditions and simple motor activation. Separately, on the same day, we performed a planimetric evaluation of the caUosal-brain ratio in all subjects using MRI. In accordance with precious results on a smaller sample, we found signs of diffuse bilateral rCBF hyperactivation in type I patients, as compared with signs of nonreactivity in type H schizophrpnics. Both activation patterns were different from a strictly contralo~i-al sensorimotor rCBF activation seen in normal persons (only 8 studied with SPECT). The planimetry of relative callosal area did not reveal differences compared to normal persons, when type IIII patients were taken together. However, the threefold increased variance as compared with that found in normal persons suggested biological heterogeneity in patients. We found an increase of relative caUosal size in type I as compared with type H patients. In the light of some recent findings linking lack of laterality of several brain functions to increased callosal size, we propose lack of lateralityldiffuse hyperactivation and increased callosal size to be connected with positive symptomatology/ good prognosis schizophrenia, and vice versa.


An analysis of collective action, collective intention, and collective intentional action, from the standpoint of the event analysis of the matrix of action sentences.


Premiums programs are common promotional tools, but have received very little empirical study. The purpose of the present study was to determine the effectiveness of a premium program done by Beer Nuts, Inc. A mail survey was sent to the first 250 respondents to . the preD)ium offer. Results indicate that most of the respondents were previous Beer Nuts consumers, would switch brands to receive a premium, would pay Qlore for a product to obtain a premium, will continue to purchase the product after receiving the premium, and will use cen~s-off coupons. Additionally, results show that the average premium consumer is between 30 and 60 years old. The results of this study will not only assist Beer Nuts, Inc. and other companies plan premium promotions, it will also encourage further premium research in the areas of psychology and marketing.


The present invention relates to a pharmaceutical composition comprising a mixture of specific HIV antigens and non-pathogenic bacteria. The specific HIV antigens includes one or more epitopes from Gag and / or Pol protein, preferably has a particle morphology. The bacterium is preferably a Lactobacillus plantarum. These compositions are useful for and / or treating preventing HIV disease in a human.


Molecular dynamics (MD) calculations have been made for liquid argon by using the Lennard-Jones (LJ) potential and the Barker-Fisher-Watts (BFW) pair potential with the Axilrod-Teller (AT) three-body interactions. The usefulness of these potentials in liquid argon was critically investigated by comparing the MD results such as dynanuic structure factors S ( Q , ω) with experimental data. It was found that velocity auto-correlation functions were more sensitive to interatomic potentials than S ( Q , ω).


The invention relates to a high effective complycarboxylic acid concrete dehumilizer with polyalkdiolether side chain, the prodn, method and the use in producing concrete. Said dehumidizer is copolymer composed by acrylic acid or salt monomer represented by general formula A, acrylic acid hydroxyalkyl resin monomer represented by general formula B, alkene sulphonic acid or its salt monomer represented by general formula C and maleic acid/salt/resin monomer with polyalkdiolether said chain represented by general formula D, the A.B.C and D are defined as direction book.


The party′ s leading cadres, especially serior cadres must watch out for the change in mind after transformation of position. Leading cadres should try hard in good aspects and keep away from bad aspects.


E E BURNS* , E A LEHNHOFF†, S C MCKENZIE‡, B D MAXWELL‡, W E DYER§ & F D MENALLED‡ *Department Plant, Soil and Microbial Sciences, Michigan State University, East Lansing, MI, USA, †Department of Entomology, Plant Pathology and Weed Science, New Mexico State University, Las Cruces, NM, USA, ‡Department of Land Resources and Environmental Sciences, Montana State University, Bozeman, MT, USA, and §Department of Plant Sciences and Plant Pathology, Montana State University, Bozeman, MT, USA


Objective To improve the contents determination method of vitamin D2 in Eight Vitamins and Calcium Hydrogen Phosphate,Zinc Sulphate Tablets.Methods The contents of vitamin D2 were measured by HPLC with a Thermo Silica chromatographic column(250 mm×4.6 mm,5 μm).n-Hexane-isopropanol(110∶1) was used as the mobile phase at flow rate 1.0 mL·min-1.The detection wavelength was 254 nm and the column temperature was 35 ℃.Results The calibration curves showed good linearity in the range of 0.5-10 mg·L-1 and the correlation coefficient was 0.995 8.The average recoveries were 100.8%(n=9).Conclusion The established method is accurate and reproducible,and can be used for the quality control of vitamin D2 in Eight Vitamins and Calcium Hydrogen Phosphate,Zinc Sulphate Tablets.


The genus Passiflora of the passion fruit crop is the most important from economic point of view. However, its cultivation in the semi-arid region is at risk due to salinity problems, requiring the identification of tolerant species, which develop better in environments with salinity problems. The objective of this study was to evaluate the effects of water salinity on growth and formation of seedlings of three species from the genus Passiflora. The treatments were distributed in a completely randomized design, adopting a 5 x 3 factorial arrangement, with five levels of irrigation water salinity (ECw) of 0.3; 1.4; 2.5; 3.6 and 4.7 dS m and three species of Passiflora: gibertii; cincinnata and edulis 'BRS Gigante Amarelo', with four replicates. P. edulis surpassed the others in leaf area, shoot, root and total dry matter and Dickson index of seedling quality. Irrigation water salinity inhibits the formation of seedlings evaluated by growth in height, stem diameter and shoot, root and total dry matter of the studied species of Passiflora. The interaction between ECw and the Passiflora species interfered significantly in height, root, shoot and total dry matter and Dickson quality index. ECw above 0.3 dS m affects the Dickson quality index of P. gibertii more,compared with P. edulis and P.


Purpose: The purpose of this study was to analyze factors affecting meaning of life in adolescents. Methods: Data were collected from April 5 to June 20, 2010. The participants for this study were 343 Korean middle and high school students, recruited from four middle and high schools located in Seoul. Data collection was conducted through the use of 7 questionnaires. The data were analyzed with the SPSS WIN 12.0 program using descriptive statistics, ANOVA, Pearson correlation coefficients and stepwise multiple regression. Results: 1) The mean total item score for the meaning of life scales was 2.99, which was slightly high. 2) There was a significant relationship between meaning of life and self-esteem, self control, parenting attitude, family satisfaction, school adjustment, and career maturity. 3) Stepwise multiple regression analysis showed that self-esteem, family satisfaction, school adjustment, parenting attitude and career maturity were predictors of meaning of life and accounted for 57.1% of the variance in meaning of life. Conclusion: Self-esteem, family satisfaction, school adjustment, parenting attitude and career maturity were variables influencing meaning of life in adolescents. These results indicate a need to develop nursing interventions to increase self-esteem, family satisfaction, school adjustment, parenting attitude and career maturity in order to improve meaning of life for adolescents.


A patient treated by chronic peritoneal dialysis developed an abdominal wall hernia at the site of the Tenckhoff catheter. The hernia led to a complete small bowel obstruction which required surgical


Author Summary: The effect of oil globule size of a 20/20/60 (w/w/w) Water-in-Oil-in-Water double emulsion on water transport was investigated for two measurement temperatures using low-resolution 1H pulsed field gradient NMR diffusometry. The measured water diffusion signals were evaluated using available data analysis procedures, which revealed that water exchange mainly occurred between the inner and outer water phase through the oil phase of a double emulsion, provided that the oil globule size was small (about 6 μm) and the measurement temperature was high (35°C). For the double emulsion with approximately 50 μm sized oil globules or using a low measurement temperature of 5°C, water exchange happened mainly between the inner water phase and the oil phase within the oil globules of the double emulsion.


Retinitis pigmentosa (RP) is an i retinal degeneration affecting appro 1 in 4000 people.' Until recently, th eight known loci for the autosomal d form, ADRP, on chromosomes 3 dopsin), 6p (peripherin/RDS), 7p (E (RP10), 8q (RP1), 17p (RP13), 17q and 19q (RP1 1).? Mutations in the rh gene account for 20-50% of ADRP, peripherin/RDS mutations account than 5%.4 Some insight into the frei of the remaining six ADRP loci can b by scanning the available published Further ADRP families have been j as linked to 7q, 8q, 17p, and 19q, su that these might be commoner loci. In 1996 a ninth locus, designate was reported by Xu et al6 as mar chromosome lcen in a large Danisl pedigree. Patients in this family wer to have a classical RP fundus with pe bone spicule pigmentation, constri retinal arterioles, and visual field loss. onset was consistently early, with no ( of non-penetrance. Night blindn apparent from birth but central visu


Recent observations in our laboratory have indicated substantial and systematic regional variations in the loss of cortical cholinergic fibers in Alzheimer disease (AD). Previous attempts to study the relationship between cortical cholinergic loss and the density of cortical pathological lesions have resulted in conflicting findings. Furthermore, most reports have correlated density of plaques and tangles with the residual level of cholinergic innervation rather than its loss. The purpose of the present study was to determine the relationship between loss of cholinergic axons and density of tangles and (3-amyloid (A(5) deposits in various cortical areas of AD brains. A(3 deposits and tangles were observed throughout the cerebral cortex. Quantitative analysis revealed almost no correlation between loss of cholinergic fibers and the density of Afi deposits. Qualitative observations revealed similar results when cored and neuritic plaques were considered separately. By contrast, cholinergic fiber loss displayed a significant correlation with the density of tangles (r = 0.52–0.79). However, in a few areas, such as the cingulate cortex, tangle density appeared to be unrelated to the loss of cholinergic fibers. These results indicate that cortical cholinergic denervation in AD is related to cytoskeletal pathology. However, the lack of a perfect relationship with cytoskeletal pathology implicates additional factors in the cholinergic pathology of AD.


A separation across the acromion is found in 3–8 per cent of adults and can be fibrous union of a fracture, or non-union of the epiphysis. The only descriptions, based on dissected specimens, derive from the last century and show that the separations are pseudarthroses, or intra-acromial joints, with synovial cavities. Examples occur of double epiphyses with two joints.

Eleven skeletalized examples, two bilateral and two through the acromio-clavicular articular facet, are described. The moderately congruent surfaces of separation showed features consistent with pseudarthrosis but gave no indication of any consistent type of movement in the joints. It is concluded that all were probably due to non-union of the epiphysis although, especially as they occurred in a population in which injuries were commonplace, some could have derived from fractures.

One specimen showed evidence of derangement of the shoulder joint, with impingement of the greater tuberosity of the humerus against the undersurface of the free part of the acromion producing eburnated attrition facets.


This article presents the critical review of the existing the scientific literature in professional approaches to the definition of the term "strategy". The existing systems notion of the basic elements were analyzed, generalizing system of the views in these categories was carried out and their basic universal provisions were allocated. Generalized interpretation of the "strategy" has been supplemented by the results of this work, the most important and universal elements of the notion that, for any branch of the economy, were laid in its foundation.