Treatment of patients with malignant tumors, largely involves the use of chemotherapy, targeted therapy and endocrine therapy (anti-hormonal and hormonal drugs). Depending on the location and nature of the tumor, surgical interventions aiming to remove some endocrine organs (in particular, ovarian, testicular, thyroid and endocrine portion of the pancreas, etc.) can lead to disruption of their function. The objective of presented study is to focus our attention mainly on the effects (including the steroid and non-steroidal components) of anticancer treatment in the endocrine system and in the outcomes associated with hormonal and metabolic changes, clinical and phenotypic features. These effects are manifested not only by changes of laboratory and instrumental parameters, but also accompanied by changes in the clinical manifestations of the disease and the patient's subjective feelings. The therapy often has adverse effects, as the anticipated final results of influence of such processes as weight gain, dyslipidemia, impaired glucose tolerance, lack of ovarian, adrenal, growth hormone and testicular function, osteopenia, hot flushes, chronic fatigue e.t.c., which often limits the success of treatment. Passive registration of such violations, and the silent watching them – is only one side of the problem rather frequent enough, the other side - are the questions about modern approaches of their correction and its feasibility. In part, this problem has a genetic basis, which, along with other indicators, can determine not only the response to anti-tumor therapy, but the severity of endocrine changes, their potential prognostic role, as well as the indications for their prevention and elimination. There are many clinically significant situations that are need to be analysed and discussed, such as: complete androgen blockade in prostate cancer patients, endocrine effects of adjuvant chemotherapy and hormonal therapy in breast cancer patients of reproductive and postmenopausal age, the expected increase of the frequency of performing of preventive salpingoovariectomies in carriers of mutations in BRCA1 and BRCA2 genes, thyroid (in particular) and adrenocortical tropism of targeted therapy, consequences of high doses of corticosteroid support therapy, etc., that demonstrate the importance of this problem, considering these facts in clinical practice and the establishment of standards for the management of patients with these problems.


Since the early 1990s, control engineering has been moving in a strongly innovative direction compared with fuzzy logic and evolutionary computing, which it inherited in recent times from two different views of the phenomenological world that, in the form of the Darwin model and the probability/uncertainty dichotomy, accompanied two centuries of scientific culture. The new line consists of the promotion of hybrid systems such as integrated neural networks and other virtual intelligence tools that apply fuzzy logic and genetic algorithms to industrial process control. This work is still in progress, so no definitive conclusions can be drawn. Virtual intelligence techniques are most efficient when used in a complementary way, where each enhances the others. Another aspect is that the term optimisation is gradually losing its effectiveness, and people may cease altogether to give it the semantic value of a paradigm that it would be silly not to consider definitive. In reality, as a systems complexity increases the definitions of its behaviour become less and less precise; at the same time, the need of precision is less and less meaningful. We are probably witnessing a process of emancipation from the rigid concept of optimisation, as predicted by T. Kuhn in his model of scientific progress (paradigm shifts). This has already happened with the concept of uncertainty. For centuries people thought that the only way to handle uncertainty was with the concept of probability (in its alternate and controversial meanings of frequency and expectation). This was the case until the development of fuzzy logic, and above all the effectiveness of its applications, generated and spread the conviction that the mechanism of reiterating vagueness can lead to the desired result by a process of finer and finer tuning.


Correct estimation of the pressure drop in filtration processes that involve fluid velocity variations is of major importance, because it allows the filtration rate and/or the energy consumed on fluid flow to be more accurately controlled. Permeability of porous filters has been often described by Forchheimer's equation, which establishes a nonlinear dependence between pressure drop and fluid velocity. Two constants, k 1 and k 2 , dependent only on the medium, quantify the viscous and inertial effects on the pressure drop curve. In this work, experimental data of airflow through 10 pores per linear inch ceramic foam filters are used to show that a single sample may have completely distinct permeability constants depending on the data range chosen for analysis. The Darcian permeability constant k 1 displays higher variation than the non-Darcian permeability constant k 2 . The conclusion is that special attention must be taken to represent permeability of highly porous structures in a large velocity range. The predictability of Forchheimer's equation generally worsens when less data are included in the curve fitting, particularly at low velocities. Careful consideration should be made if constants k 1 and k 2 are intended to be used for permeability estimation beyond the fitting range.


Based on the problems of desertification and salinization in the Qaidam Basin, this paper studies the coupled stress of saline-alkali and drought conditions on the seed germination of Haloxylon ammodendron from Qaidam provenance, and clarifies the comprehensive effect of salt, alkali and drought stress on Haloxylon ammodendron seed germination vigor. It provides a reference for the research on the resistance of Haloxylon ammodendron and provides a theoretical basis for improving the breeding efficiency of Haloxylon ammodendron population in the area of bad situation.


Background: The global literature has revealed that cultural orientation, adaptation and social capital may influence HIV-related sexual behaviours among migrants. However, whether cultural orientations influence adaptation and social capital and thereby affect sexual behaviour is not well understood. Method: This study examined whether individualistic and collectivistic orientations, adaptation and social capital have direct and indirect effects on condom use among rural-to-urban migrants in China. We collected data from 641 migrants aged 17 to 30 years, in Beijing, China. Participants completed scales on individualistic orientation, collectivistic orientation, adaptation, social capital and condom use. Structural equation modelling was used for model testing. Results: Condom use was positively associated with an individualistic orientation and social capital. An individualistic orientation had an indirect effect on condom use via social capital. Women reported higher levels of condom use than men. Conclusion: Future sexual risk prevention and intervention programmes to improve sexual health should pay more attention to building social capital and engaging with relevant cultural factors.


In this paper, we propose a segmented pulse shaping technique to increase the quantization level of a digital direct-driven speaker without increasing the number of output units. The digital direct-driven speaker consists of a multi-bit delta-sigma modulator and a noise-shaping dynamic element matching circuit. Because the multi-bit outputs drive each of the driver circuits directly, the system can be driven at low voltage with high efficiency. However, it is necessary for the number of loudspeakers or voice coils and driver circuits to be same as the number of quantization levels. Therefore, increasing the number of quantization levels is not a straightforward process. The method proposed here can increase the number of quantization levels without increasing the number of output units, thereby improving the signal-to-noise ratio and reducing out-of-band noise. This paper compares the proposed system, which uses a five-bit quantizer, with the conventional system, which uses a three-bit quantizer, when eight loudspeakers are implemented as an example. The investigations included MATLAB/Simulink-based simulations and implementation using a field-programmable gate array (FPGA) board. As a result, it was shown that the proposed system reduces out-of-band noise by 12 dB and improves the signal-to-noise ratio by 12 dB.


In recent years titanium alloys demand has increased considerably. Although many progresses have been made during the last years, machining titanium alloys still is considered as quite challenging. This paper shows the results of the fundamental research carried out to understand the thermochemical loads when machining Ti-6Al-4V. A comparative study of empirical and modelling results is carried out on cutting forces and temperatures in orthogonal conditions. Empirical cutting forces are obtained with a piezoelectric sensor while the temperature fields are obtained with an infrared camera. The commercial software AdvantEdge (finite element modelling) is employed to obtain temperature and forces. In 3D, analytical modelling based on energy approach is used to estimate cutting forces while finite difference method is employed to obtain temperature fields. Results show a good correlation among all the approaches.


In order to ameliorate the stability of the network, this paper proposes a clustering algorithm based on fuzzy C-means for VANET (FCM- WCA). The algorithm first determines the neighbor list of the vehicle by calculating the angle between the vehicles, preventing the vehicle from erroneous clustering on the intersecting road. Then, the fuzzy C-means algorithm is used to effectively cluster the vehicle, and the cluster head is selected by using the vehicle moving direction, the weighted mobility value and the entropy as the indicators of the weighted clustering algorithm.


NF 9891. Part of a gilt-bronze equal-armed brooch found at Northton, Harris, is identified as the first British find of Petersen's 'Troms type', a specifically Norwegian form datable to 9th century. The reverse of the brooch shows a clear positive impression of a fine regular textile with an unusual herringbone twill pattern. AR


One of the great problems that absorbs Smith's attention is his interest in laying bare the mecha nism by which society hangs together. How is it pos sible for a community in which everyone is busily following his self-interest not to fly apart from sheer centrifugal force? With no central planning authority, what guides each individual private busi ness so that it conforms to the needs of the group?1 These questions lead Smith to a formulation of the laws of the market that is "the private interests and passions of men" are led in the direction "which is most agreeable to the interest of the whole


A new digital watermarking algorithm of hybrid transform domain based on DWT and DCT is proposed.The wavelet coefficient of the original image is got through wavelet transform,and the low frequency coefficient is seen as a subimage.Then the binary watermark image is permuted and coded,the watermark is embedded into the coefficient which got from the DCT of the subimage.The proposed algorithm can detect and extract the watermark without the help of the original image.Experimental results show that this new algorithm is imperceptive and robust,and has a good performance against the scaling and the local attack.


Objective To investigate maternal pain in the implementation of nursing intervention on the impact of maternal.Methods Ways to adopt the principle of random sampling taken from the same period 200 cases of maternal hospitalization,the observation group were randomly divided into 100 cases,routine obstetric care,and analgesic use of non-invasive method to implement nursing interventions;100 cases of the control group,given only routine obstetric care.Results Delivery of two sets of maternal pain and mode of delivery were compared.The results of the observation group the degree of maternal pain during delivery than the control group significantly decreased(P0.05),there was a significant difference;natural birth rate of the control group(P0.05),there was a significant difference.Conclusion Using non-invasive method of relieving pain interfere with the implementation of the maternal care throughout the delivery process in the best psychological,physiological status,delivery can reduce the pain,reduce the cesarean section rate,improve the natural birth rate without affecting maternal and child health and safety.


Annual and seasonal displacements of ploughing boulders were investigated at Finse, southern Norway, by traditional surveying and differential carrier‐phase global positioning system measurements. Annual displacement rates were mainly below 10 mm/year, although one particular season showed rates of 26 mm/year on average. There was a tendency for larger boulders to travel faster. Seasonal displacements were restricted to the annual freeze‐thaw cycle. The frost heave seems to have a significant horizontal component, which does not necessarily point in the downslope direction. Thus, the concept of frost creep is not applicable to the investigated ploughing boulders. On the other hand, due to tilting of the boulders, a momentum may be gained during thaw consolidation that could induce downslope displacements. Such a process will work together with gelifluction.


Fostering cultural identity from the perspective of civic consciousness is an effective way to deal with all kinds of multiple and complex identity relations among transboundary ethnic groups in Xinjiang.Thus,it is necessary to enhance their national identity and their consciousness of education right and multi-culturalism in order to construct our national spiritual pillar and reveal the universal value of the Chinese culture and the traditional ethnic cultures and to help improve the relations between religious beliefs and ethnic cultural identity.


In January 1999 several European countries adopted a common currency, the "euro". This important economic event provided an opportunity to examine the determinants of risk management in an environment where exposure to foreign exchange (FX) risk was considerably reduced. For a sample of French firms we found the decline in the use of FX derivatives was greater for firms with substantial sales within the euro zone and less for firms in industries that still had significant imports from outside the euro zone. The focus on derivatives adds to existing research, as it is a more explicit indicator of a reduction in the resources devoted to hedging. The reduction in hedging was not in direct proportion to the reduction in FX exposure, implying that euro risk was hedged more intensely than French franc risk in the sample of French firms over the chosen years.


A novel ameliorated phase generated carrier (PGC) demodulation algorithm based on arctangent function and differential-self-multiplying (DSM) is proposed in this paper. The harmonic distortion due to nonlinearity and the stability with light intensity disturbance (LID) are investigated both theoretically and experimentally. The nonlinearity of the PGC demodulation algorithm has been analyzed and an analytical expression of the total-harmonic-distortion (THD) has been derived. Experimental results have confirmed the low harmonic distortion of the ameliorated PGC algorithm as expected by the theoretical analysis. Compared with the traditional PGC-arctan and PGC-DCM algorithm, the ameliorated PGC algorithm has a much lower THD as well as a better signal-to-noise-and-distortion (SINAD). A THD of below 0.1% and a SINAD of 60 dB have been achieved with PGC modulation depth (C value) ranges from 1.5 to 3.5 rad. The stability performance with LID has also been studied. The ameliorated PGC algorithm has a much higher stability than the PGC-DCM algorithm. It can keep stable operations with LID depth as large as 26.5 dB and LID frequency as high as 1 kHz. The system employing the ameliorated PGC demodulation algorithm has a minimum detectable phase shift of 5 μrad/√Hz @ 1 kHz, a large dynamic range of 120 dB @ 100 Hz, and a high linearity of better than 99.99%.


The ZJ70LDB drilling rig can be used for exploration and development of 7 000 m oil-gas wells.To improve the speed of the quick installment of the rig,the measures are suggested to improve the driving structure and base structure on the basis of analyzing the connection of the rig with the original structure as well as the existing problems.The universal shaft is used to replace the chain drive and thus the bottleneck problem of rig installment has been solved so as to install all component parts simultaneously and improve the installment speed.By improving the substructure,the installment step for adjustment of substructure horizontality has been removed.The whole dragging of the rig without the disassembly of the main machine has been achieved twice,covering the distance of 15 meters.The peripherals including the electricity control room,motor room and oil-water tank need not be moved.One installment can fulfill a task of drilling 3 wells,satisfying the requirement for drilling cluster wells.


Abstract Trans-resveratrol, a naturally occurring lipophilic polyphenol present in various foods, is well known for its therapeutic use. Owing to their exciting therapeutic potential, we developed a simple and precise stability indicating reverse-phase high performance liquid chromatography (RP-HPLC) method as per International Conference on Harmonization guidelines for quantitative analysis of trans-resveratrol in a commercial nutraceutical product and in-house nanoliposomes formulation. The chromatographic separation was attained on Phenomenex Luna C18 column (150 x 4.6 mm, 5 μm) at 30°C using UV detection at 306 nm. The optimized mobile phase consisted of acetonitrile/water (30:70, v/v) at the flowrate of 1.0 mL/min under isocratic mode of elution. The proposed method was found to be accurate, precise and linear with regression coefficient of 0.999 which could analyse the samples with as low as in nanograms with percent recovery in the acceptable range of 97.97 - 102.80 %. In addition, stress degradation study was also carried out wherein analyte peak was found to be well resolved. Hence, the present investigation confirmed that the developed method can be employed for the analysis of trans-resveratrol in different formulations, and also of huge benefit in careful selection of experimental conditions and its implication for storage and formulation development.


Distant metastasis is the chief cause of cancer mortality. This is particularly true for breast cancer, for which the last decades have brought notable advances in locoregional (surgical, radiation) and systemic (hormonal, chemotherapies) treatment approaches. However, metastatic progression remains a poorly understood process. Therefore, it has been difficult to predict the presence of occult micrometastases in patients and the molecular and cellular mechanisms critical for their formation and progression. As a result, devising novel anti-metastatic therapies has been and remains a great challenge in oncology. Certain gene signatures (eg, MammaPrint, Oncotype DX) have shown statistically significant association with distant disease recurrence and are in clinical use as prognostic markers. These signatures appear to be driven predominately by genes reflecting the level of proliferation and hormone receptors in those tumors. But in addition to intrinsic properties of the cancer cells, a key role has been proposed for the tumor microenvironment in cancer cell survival and progression to metastasis. The contribution of the microenvironment may enhance an otherwise very inefficient process (1,2) and includes angiogenesis and the multi-faceted participation of activated fibroblasts and immune cells. Our understanding of this process is largely based on evidence from mouse models. However, the murine models have several limitations and may not fully reproduce the metastatic cascade in patients. Most metastasis studies have utilized experimental models in which cancer cells are injected as a bolus into the circulation upstream of the metastatic site. The limitation of such an approach is that it overlooks critical events taking place in the primary tumor and systemically prior to metastatic cell colonization. Models featuring spontaneous metastasis from a primary tumor are markedly better; however, these models generally do not metastasize to the same site(s) as the human disease they aim to model. Furthermore, such models are rare, and their metastatic cascade phenomena may represent only a small subset of possible human cases. Both implanted cancer cell models and genetically engineered mouse models—the current gold standard for understanding cancer biology—have these limitations. Finally, although most new agents are first tested in the metastatic setting, more recently there has been considerable interest in evaluating novel therapeutic agents in the neoadjuvant (preoperative) setting for some aggressive subtypes of breast cancer (eg, triple-negative and human epidermal growth factor receptor 2 [HER2]-positive). This approach offers the potential for accelerated Food and Drug Administration approval if the agent demonstrates a substantial increase in the rate of pathological complete response of the primary cancer (3). However, therapeutic effects on the primary cancer may not accurately reflect effects on micrometastatic disease in the setting of a different microenvironment. Preclinical studies often provide little insight in this regard, because most of them are done in primary tumors with no metastasis. This discordance may help explain the observation that drugs that increase pathological complete response rates have failed to decrease rates of metastatic disease. In a report in this issue of the Journal, Rohan et al. examined whether the frequency of microstructural units formed by cancer cells, perivascular macrophages and endothelial cells— termed Tumor MicroEnvironment for Metastasis or TMEM— are associated with the risk of metastatic recurrence (4). The authors identified the cancer cells that comigrate and interact with macrophages at intravasation sites based on the expression of Mena, which is an Ena/VASP protein family member and a


Background: Health financing provided by the government greatly helps the implementation of health system in the decentralized era. General Allocation Fund and Local Revenue and Expenditure Budget are apparently inadequate to finance health service. Some efforts have been made to finance health service such as Community Health Insurance (Jamkesmas), Childbirth Insurance (Jampersal), and Health Operational Fund (Bantuan Operasional Kesehatan/BOK). These are meant to achieve Millennium Development Goals in 2015. The practice of coordination from planning to implementation and stakeholders' commitment can affect the process of maternal and child health service. Coordination is definitely needed to run the program policy and prevent the overlapping financing in order that the objective of the program can be achieved. Objective: To evaluate coordination of planning, implementation and stakeholders' commitment in relation to maternal and child health (MCH) service in Lombok Tengah District. Method: This was a descriptive-analytical study with a qualitative approach and a case-study design. Samples were taken purposively. The data were obtained through in-depth interview, observation and documentation analysis. Result: The planning coordination of MCH health financing had not been optimal, even despite the involvement of cross sector and program. However, the organizations of health professionals were not involved in program planning. The coordination of health financing implementation had not been optimal as well. Even though there was no overlapping financing from some different sources, in the policy implementation there was cost sharing for referral and drugs. Private sectors were not involved in the implementation of Jampersal. Stakeholders' commitment was relatively optimum as reflected from the policy and action in health development acceleration particularly MCH. The process of MCH service at both primary and secondary level could run well. Conclusion: Coordination of MCH financing implementation in Lombok Tengah District through BOK, Jampersal, Jamkesmas, Community Empowerment National Program of Healthy and Smart Generation and Local Revenue and Expenditure Budget had not been optimal; therefore, it needed to be improved to eliminate cost sharing. Professional organizations and private health providers were not yet involved in the program planning and implementation. Keywords: coordination, stakeholders' commitment, health financing, maternal and child health, program evaluation


Real-time HTTP streaming has gained global popularity for delivering video content over Internet. In particular, the recent MPEG-DASH (Dynamic Adaptive Streaming over HTTP) standard enables on-demand, live, and adaptive Internet streaming in response to network bandwidth fluctuations. Meanwhile, emerging is the new-generation video coding standard, H.265/HEVC (High Efficiency Video Coding) promises to reduce the bandwidth requirement by 50% at the same video quality when compared with the current H.264/AVC standard. However, little existing work has addressed the integration of the DASH and HEVC standards, let alone empirical performance evaluation of such systems. This paper presents an experimental HEVC-DASH system, which is a pull-based adaptive streaming solution that delivers HEVC-coded video content through conventional HTTP servers where the client switches to its desired quality, resolution or bitrate based on the available network bandwidth. Previous studies in DASH have focused on H.264/AVC, whereas we present an empirical evaluation of the HEVC-DASH system by implementing a real-world test bed, which consists of an Apache HTTP Server with GPAC, an MP4Client (GPAC) with open HEVC-based DASH client and a NETEM box in the middle emulating different network conditions. We investigate and analyze the performance of HEVC-DASH by exploring the impact of various network conditions such as packet loss, bandwidth and delay on video quality. Furthermore, we compare the Intra and Random Access profiles of HEVC coding with the Intra profile of H.264/AVC when the correspondingly encoded video is streamed with DASH. Finally, we explore the correlation among the quality metrics and network conditions, and empirically establish under which conditions the different codecs can provide satisfactory performance.


In this paper we introduce the design and implementation of a binocular stereo based visual odometry.The major modules of the implementation are illustrated thoroughly.Methods based on different feature detection and matching algorithms are compared with each other.By examining the experimental results with the ground truth data attained from Total Station,we show that our algorithms are efficient and effiective.


Flash memory has now become a crucial component in building Linux-based embedded computers. As the overall flash-memory lifetime is concerned with block endurance, wear leveling is needed to evenly erase all blocks. This paper presents a modularized implementation of a wear-leveling algorithm. Our goal is to instantly enable any existing Linux-based flash file systems the ability of wear leveling without to modify the file systems.


Her memory danced. She heard her father singing to quiet the baby's fret. "Up, little horse, let's hie to the mill." She roved in \ision, beyond her father, beyond the baby, to one whose countenance was seen as through a mist. It was her mother's face, cherished as a good dream is cherished— she who had held her in the warm, safe nest of her arms. Nezzie slept at last, laboring in sleep toward waking. She waked to morning and her sight reached dimlv across the snow. An ax hewed somewhere, the sound coming to her ears without meaning. She lifted an ann and glimpsed the gray of her hand and her bloodless fingers; she drew herself up by the fence and nodded to free her bonnet of snow. She felt no pain, only languor and thirst. The gap was three panels distant and she hobbled toward it. She fell. Lying on the ground she crammed snow into her mouth. Then she arose and passed under the bars, hardly needing to tilt her head. Nezzie came down the slope. She lost a shoe and walked hippity-hop, one shoe on, one shoe off. The pasture was as feathery as a pillow. A bush plucked her bonnet, snatching it away; the bush wore the bonnet on a limb. Nezzie laughed. She was laughing when the cows climbed by, heads wreathed in a fog of breath, and when a fox horn blew afar. Her drowsiness increased. It grew until it could no longer be borne. She parted a clump of broomsage and crept inside. She clasped her knees, rounding the grass with her body. It was like a rabbit's bed. It was a nest.


In the area of machine learning, different techniques are used to train machines and perform different tasks like computer vision, data analysis, natural language processing, and speech recognition. Computer vision is one of the main branches where machine learning and deep learning techniques are being applied. Optical character recognition (OCR) is the ability of a machine to recognize the character of a language. Pashto is one of the most ancient and historical languages of the world, spoken in Afghanistan and Pakistan. OCR application has been developed for various cursive languages like Urdu, Chinese, and Japanese, but very little work is done for the recognition of the Pashto language. When it comes to handwritten character recognition, it becomes more difficult for OCR to recognize the characters as every handwritten character's shape is influenced by the writer's hand motion dynamics. The reason for the lack of research in Pashto handwritten character data as compared to other languages is because there is no benchmark dataset available for experimental purposes. This study focuses on the creation of such a dataset, and then for the evaluation purpose, a machine is trained to correctly recognize unseen Pashto handwritten characters. To achieve this objective, a dataset of 43000 images was created. Three Feed Forward Neural Network models with backpropagation algorithm using different Rectified Linear Unit (ReLU) layer configurations (Model 1 with 1-ReLU Layer, Model 2 with 2-ReLU layers, and Model 3 with 3-ReLU Layers) were trained and tested with this dataset. The simulation shows that Model 1 achieved accuracy up to 87.6% on unseen data while Model 2 achieved an accuracy of 81.60% and 3% accuracy, respectively. Similarly, loss (cross-entropy) was the lowest for Model 1 with 0.15 and 3.17 for training and testing, followed by Model 2 with 0.7 and 4.2 for training and testing, while Model 3 was the last with loss values of 6.4 and 3.69. The precision, recall, and f-measure values of Model 1 were better than those of both Model 2 and Model 3. Based on results, Model 1 (with 1 ReLU activation layer) is found to be the most efficient as compared to the other two models in terms of accuracy to recognize Pashto handwritten characters.


Abstract Cloud computing brings the business computing to a novel pattern from manufacturing to services. Clouds enhance the next generation data centers as a network of virtual computing services. Resource allocation and distribute should be as per Quality of Service (QoS) with Service Level Agreement (SLA) to decrease energy intake and carbon release. Cloud environment resources requests are concurrent and competitive. Efficient resources handling is elementary need in data center and should be performed through the implementation of efficient and dynamic load balancing algorithm. Optimization is a scientific discipline to discover optimal solution from numerous solutions for a problem. In NP-hard problem, finding the optimal solutions for algorithms is expensive. Hence, many of the proposed algorithms focus on searching approximate solutions for VM load balancing. Heuristic, meta-heuristic and hybrid optimization strategy gaining popularity as find optimized solution in reasonable time for complex problems. A hybrid meta-heuristic is proposed using nature inspired Genetic Algorithm and Particle Swarm Optimization approaches. Optimized results achieved in terms of performance when proposed approach evaluated on Cloud Analyst Simulation tool.


meditations about various aspects of spiritual life meditations on various aspects of the spiritual life dofn meditations on various aspects of the spiritual life 1926 meditations on various aspects of the spiritual life dfnk meditations on various aspects of the spiritual life meditations on various aspects of the spiritual life rakf meditations on various aspects of the spiritual life eaal daily meditations with the holy spirit spiritual life morning notes 365 meditations to wake you up prather hugh daily meditations with the holy spirit spiritual life intimate papers of colonel house 4 volumes bcl1 u s culture of complaint the fraying of america compax gita meditations suryadevananda great cases of sherlock holmes alongz music theory past papers 2012 abrsm grade 1 of unknown on prayers & meditations vedanta letters to his family an autobiography tapsey management operations of flying clubs eleina essentials of firefighting 5th edition study guide download chemical reaction engineering levenspiel 2nd edition roller coaster physics gizmo answers paycox essentials of meditative life holy teachings of vedanta surgical technology principles and practice 6e firext hercules g3400 parts manual dioro kodak easyshare v610 manual yunfan small group counseling for children k 2 iwsun haier lv 1510p tvs owners manual quafe 2004 bmw 330xi owners manual eleina our$carmelite$promise:$$to$ponder$always$in$imitation$of beyond malice the medias years of reckoning quafe parrillo nutrition manual aadver toyota staxio manual cafebr relentless pursuit a novel xeneo roads and vehicles industrial archaeology mdmtv managing the partnership between higher education and industry windfall apples wmcir what a wonderful bird the frog are an assortment of philosophy, experience and the spiritual life


Objective To evaluate the application value of the Lung Ventilation/Perfusion Scintigraphy for the diagnosis and curative effects in patients with acute pulmonary thromboembolism. Methods Lung Ventilation/Perfusion Scintigraphy was performed in 65 patients with known or suspected pulmonary thromboembolism within two weeks after the onset of symptoms. Follow - up study was performed in those patients who received thrombolytic therapy and/or anti - coagulation. Results High, medium and low probability for pulmonary thromboembolism on Lung Ventilation/Perfusion Scintigraphy was present in 45, 12 and 8 patients respectively. Follow-up study showed improved pulmonary perfusion in 51 patients, 41 patients of which with high probability, 9 with medium probability and only 1 with low probability. Pulmonary perfusion was unchanged in 14 patients. Conclusion Lung Ventilation/Perfusion Scintigraphy is a noninvasive, accurate technique for the diagnosis and assessment of therapeutic efficacy in patients with pulmonary thromboembolism.


Summary Sixty-four female freshmen were interviewed about various attitudes toward their college. Halfway through the interview, three groups of subjects were told falsely by the experimenter that their responses to the questions had been significantly longer than average, of about average length, or significantly shorter than average. A fourth group of subjects was given no false feedback. Subjects with longer than average false feedback increased their response lengths significantly during the last half of the interview and rated the interview questions significantly more favorably than other subjects. Subjects with shorter than average false feedback also gave significantly longer responses during the second half of the interview, but did not differ from average false feedback and no feedback subjects in their favorability toward the interview questions. Results of the study were discussed in terms of Bem's self-perception theory.


Conversion coating on zinc plating film using Cr (III) compound as main constituent were investigated. Corrosion resistance of the film were evaluated by salt spray test and measuring polarization resistance, Rp. Surface analysis were made to determine the elements on the film and depth profile by Auger electron spectroscopy (AES).Corrosion resistance of the passive film composed of both Cr (III) and silicate was better than those film consisting of each own component. With addition of phosphate and by post-treatment with dipping in colloidal silica sol solution, the corrosion resistance of the film was improved more. The evaluations of the film by measurement of polarization resistance were almost same results. The results of surface analysis using AES indicated that Cr (III) in the film was increased with addition of silicate, and that the thickness of the film was increased with addition of phosphate. These were thought to be responsible for improving the corrosion resistance of those Cr (III) film composed of silicate and phosphate.


The relevance of family businesses in the world economy has led researchers to study them in various fields and from various perspectives. However, the role played by family businesses in the private health care sector has hardly been analyzed. The objective of this research was to focus on the historical evolution of the family business in the field of private health, attempting to determine the variation in its contribution to the sector during 1995– 2018. For this purpose, we constructed a database with the existing private hospitals in Spain, classifying them according to family and non-family ownership for the years 1995 and 2018 and performing a cross-sectional analysis. We observed an almost 60% survival rate for family businesses. We propose implementing the methodology of the case study for future research. La empresa familiar el sector sanitario: Evolución y perspectivas empresa Performance;Family Business A bstract The present conceptual paper depicts Internal Market Orientation (IMO) theory development conceptualization with a contemplation of new conditions, realities and technologies available to modern businesses in service industries. Based on the results of a conceptual study, this study proposes a novel IMO framework which reflects the noted global changes that affects family businesses. The denoted model introduces novelty variables including Information Communication Technologies (ICTs) and Outsourced Personnel structural constructs. They avail to measure the effect of IMO implementation on job satisfaction and employee commitment that, in their turn, exhibit a positive impact on business performance in


Abstract Facade maintenance actions are driven by results obtained in the inspection phase. Some methodological proposals aimedat optimizing the inspection process have been discussed, notablydigital image processing (DIP) techniques associated with unmanned aerial vehicle (UAV) imagery. Using UAV speeds up the access to the inspected area, and DIP techniques help to automate the identification of pathological manifestations. This article aims to apply DIP techniques to detect areas where the ceramic cladding on building facades is detaching. The methodology referred to herein starts with the creation of a database (images) captured by cell phone and UAV. The object detection algorithm YOLO (You Only Look Once) was applied to the database images. The results indicated these techniques are very promising, with a 94% precision level in the tests performed. The precision index obtained indicates that the model is applicable in practice and discussions about its limitationshelp improve the proposed methodology.


The present invention relates to a universal aquatic vegetation radiative transfer model. The steps are as follows: the whole system is divided into aquatic vegetation consistent with several uniformly mixed, the level of the optical properties of the dielectric layer; the vegetation canopy structure, observation geometry and other conditions, a single blade PROSPECT reflectance and transmittance obtained model calculation input to SAIL model calculates canopy extinction and scattering coefficients of the radiation; given component concentration in the water body, the extinction II water optical model is calculated based on backscatter coefficients, and then calculate water vegetation mixed dielectric layer absorbent body of water after the scattering coefficient; calculated water wave face model according to Cox-Munk scattering matrix diffuse radiation and direct radiation; computing system according to aquatic vegetation bidirectional reflectance addition method. The present invention enables an accurate description of aquatic vegetation Reflectance and reflection characteristic direction, to achieve accurate sensing radiation with aquatic vegetation and water and the mechanism of interaction of environmental parameters and basic premise inversion.


Image-based researchers have previously noted the failure of institutional ethics guidelines and frameworks to adequately address the issues and methodologies used in visual research, citing a need for more creative and flexible approaches. Screen scholars work with traditional (non-visual) data sources, human subjects, visual data, and colleagues. This produces a range of ethical issues which are not addressed by institutional frameworks, based as they are on individualism and utilitarian ideals. Drawing on the ideas of Johann Neem and Savannah Dodd, this chapter suggests the need to shift our research practices towards a more collective, reflective, and empathetic mode of working.


Abstract Preoperative diagnostic confidence and donor site assessment are important for all hair transplant surgery patients. While the majority of patients seek hair transplantation for male or female pattern hair loss (androgenetic alopecia [AGA]), there are mimickers that must be differentiated from patterned hair loss, as they alter the candidacy of the patient for transplantation. They are termed mimickers as they also can present with patterned hair loss. The use of trichoscopy has become increasingly popular for such use. Patterned hair loss mimickers, which include the underappreciated alopecia areata incognita (AAI) and fibrosing alopecia in patterned distribution (FAPD), can be identified clinically with key trichoscopic findings such as yellow dots and peripilar casts, respectively, that correlate with their histologic diagnosis. Donor hair density and putative hair pathology of the safe donor area can also by assessed via trichoscopy. This article discusses the use of trichoscopy, particularly for diagnosing mimickers of patterned hair loss as well as preoperative donor site assessment.


This reviewer identified foiur major discussions which have particular importance in family ministry. First, the authors take a different stance from tha t of most current church programs as well as approaches to services with troubled, families in positing parenting—not marriage— as the primary family relationship. Their sound theological argument provides a significant corrective to the current elevation of marriage as the centerpiece of Christian family relationships and the resulting sec ond class s tatus of single persons.


E ven though physicians, lawyers, dentists, school teachers, life insurance brokers, and peddlers were licensed in the United States as early as 1890,I nursing occupational licensure did not begin until 1938, when New York became the first state to pass such a law.* By 1962, eight states had mandatory licensing laws, and sixteen more had nursing boards which claimed that licensure was mandatory.' Today every state requires that nurses who practice within its jurisdiction possess licenses.' Since the purpose of nursing licensure is protection of the public, the state may require qualifications which are reasonably related to the practice ofnursing.' A license, because it is granted upon condition, is not a permanent right, and the state may revoke it if the licensee does not continue to meet licensing standards. The state also has discretion to use remedies less extreme than revocation. It may limit or suspend the license, and/or fine or reprimand the nurse.6 The state may not, however, revoke a nurse's license arbitrarily; it must have a reason far more substantial than the offended sensibilities of the state nursing board members.' Grounds for revocation of a license are set forth in state statutes, and a state may not revoke a license for causes which are not contained within the statute.8


The Vice-President (Mr J. F. Hylands, F.F.A.): Our authors this evening are most welcome, Stephen Richards and Dr Iain Currie. Stephen Richards is a graduate of Heriot-Watt. He graduated in actuarial mathematics and statistics. He has worked since 1990 in life assurance and nowadays runs his own consultancy and software business specialising in the analysis of mortality and other demographics. Dr Iain Currie is Reader in Statistics in the School of Mathematical and Computer Sciences at Heriot-Watt University. Iain's main research interest is in multi-dimensional smoothing methods with particular application to the modelling and forecasting of mortality rates. He is responsible for developing GLAM, which is a high-speed/low storage method of smoothing data that are arranged in multi-dimensional arrays. I am sure he would be delighted to tell people more about that afterwards. I am delighted that the authors are here this evening to present the paper. The paper is the fruit of a research award from the Actuarial Profession where we are endeavouring to focus research activities on particular areas of interest or importance to the profession.


DOI: 10.21276/sjebm.2018.5.8.10 Abstract: Despite a long tradition of apiary farming in West Pokot, Kenya, records show that farmers in the area are yet to record an improvement in their income generation. This has been attributed to the utilization of outdated and obsolete marketing strategies that don't take into account the dynamic nature of consumer demands. To address this challenge, a study was undertaken in a bid to identify the market conduct and performance of honey marketing in West Pokot, Kenya. The discussions in this paper are premised on the findings of the study. The study adopted a survey research design and had a target population of 400 farmers and 50 traders who had experience in honey production and marketing of honey. A sample size of 120 farmers and 14 traders was obtained through purposive sampling and systematic sampling, respectively. Primary data collection was done by means of individual interview and group discussions using questionnaires and checklists while secondary data was collected from different documented sources. The honey marketing performance was measured using marketing margins complemented with analysis of costs and gross profits generated by different marketing channel actors. The findings of the study indicated that honey market concentration ratio in the study area was 94.88 percent suggesting a weaker oligopoly market type. This paper calls for a strengthening of marketing through establishing and developing co-operative societies and other honey marketing institutions. It is also essential to integrate bee keeping activities with water harvesting to secure the livelihood of apiary farmers.


According to the established SYBR Green Ι fluorescent-based real-time reverse transcription polymerase chain reaction(RT-PCR) method for detection of horse toll-like receptor mRNA,the mRNA levels of TLR3,TLR7,TLR8 and TLR9 were analyzed in different tissues of Mongolia horse.The results showed the TLRs mRNA could be detected in heart,liver,spleen,lung,kidney,stomach,duodenum,jejunum,caecum and bone marrow.TLR3 mRNA level was the highest in kidney and the lowest in spleen.In contrast to TLR3,TLR7,TLR8 and TLR9 mRNA levels were the highest in spleen.TLR7 and TLR8 mRNA levels were the lowest in stomach,TLR9 was lowest in jejunum.In different immune organs,TLR7,TLR8 and TLR9 mRNA levels were higher in spleen than that in bone marrow,while the expression of TLR3 mRNA was opposite.In different intestinal segments,TLR3,TLR7,TLR8 and TLR9 mRNA levels were higher in caecum than in duodenum and jejunum.The expression of TLR3 and TLR8 mRNA were higher than TLR7 and TLR9 mRNA.The results indicated that there was comparatively large difference on the transcription level of TLRs mRNA in different tissues,which may be associated with the ability to recognize pathogens and different resistance in Mongolia horse.


Purpose: The limbus and its stem cells are very important in the pathogenesis of pterygium. In this study, the efficacy of limbal stem cells and conjunctival autograft transplantation for the treatment of primary pterygium will be assessed. Design: Prospective noncomparative cohort study. Materials and Methods: Forty-two eyes of 42 patients with grade I-III primary pterygium were included in the study. Pterygium excision was performed followed by superotemporal limbal stem cells and conjunctival autograft transplantation in all cases. Recurrence of pterygium and complications within a mean follow-up period of 18.26 months (10-28 months) was studied. Results: Recurrence of pterygium occurred in two eyes (2/42; 4.75%). No significant complications were noted. Apart from re-operation in the two recurrent cases, no further surgical interventions were needed in any case. Conclusions: Limbal stem cells and conjunctival autograft transplantation is a safe and effective technique for the treatment of different grades of pterygium. It is very useful in preventing pterygium recurrence, which is a major problem in pterygium surgery.


In recent decades, CFRP materials have been extensively used in engineering process and become an important material in many industries. Ultrasonic guided waves, Lamb waves, are useful for evaluating the integrity of CFRP structures. However, the variation of the Lamb wave velocity causes difficulties for interpretation of observed signals. It is important, therefore, to establish the crack detection criterion independent of wave numbers. The aim of this work is to retrieve divergence of the phase velocity vector field caused by the scattered waves and to reconstruct the image of sub-surface defects. In this study, the problem of reconstructing a super-resolved image of defects in a shell structures over Lamb wave field is considered. This study discusses the image reconstruction process based on the divergence of the phase velocity vector field of the scattered wave fronts.


The library and information communities are going through unprecedented changes. Libraries are rapidly evolving from a paper to digital presence and the physical library is redefining itself for a new role. This presentation will focus on some of the key transformational changes of our time including the emergence of eBooks and what they mean for collection development and new ways of purchasing; the threat and opportunities of the digital distribution of eBooks and media which could leave the library as an outsider for popular materials; the growth of discovery interfaces and how they are changing the ways libraries present themselves; the role of digital repositories as the new "special collection" and university storehouse; the emergence of social networks and how we integrate with these tools; the popularity of mobile interfaces and what it means for our user interfaces; and the evolution of consortia as regional and national power brokers for purchasing. In order for libraries to remain economically viable and relevant for user needs the institution must simultaneously change on many fronts.


Experiments were conducted at the University of Rosario Experimental Farm, Zavalla in 2005 and 2006 to study the effect of glyphosate on the control of Convolvulus arvensis, Oenothera indecora, Iresine diffusa, Parietaria debilis, Rumex paraguayensis and Trifolium repens at the vegetative and reproductive stage. The experiments were established in a complete randomized design with the following factorial arrangement of treatments: year, species, vegetative and reproductive growth stages and glyphosate 48% (4X, 2X, 1X, 1/2X, 1/4X, 0X) being 1X the recommended dose (1,200  g  a.i. ha-1). The relationship between glyphosate dose and weed biomass control was established with a log-logistic model. The degree of tolerance was compared by LD50. In both stages, the higher LD50 was obtained for I. diffusa indicating that this is the species most tolerant to glyphosate among those studied. The number of species tolerant to glyphosate is lower at the vegetative stage than at the reproductive stage


The risk relationship between hard water and reduced cardiovascular disease is well known, but it's the magnesium portion of the hardness that accounts for most of the beneficial effect. Magnesium is important in hundreds of biochemical processes, and adult daily requirements are approximately 300‐350 mg/day. Most Americans consume less than the optimal daily amount of magnesium recommended for good health.


The postcranial skeleton of the Ponto-Caspian endemic benthophilines Anatirostrum and Benthophilus show unique specializations within gobioid fishes. Precaudal and caudal vertebrae are reduced in numbers and the dorsal pterygiophore insertion pattern is modified. Pterygiophores, which support no spine or segmented fin ray, are present in the skeletons at the rear of the first dorsal fin and at the second dorsal fin origin. Because of the low number of vertebrae the second dorsal and anal fin pterygiophores of Anatirostrum and Benthophilus are displaced anteriorly. The pterygiophores that support the first spine of these two median fins are positioned opposite to each other.


The realization of intrapreneurship activities is one of the important points in the achievement of a unique market position for the businesses to which the blue ocean strategy is implemented, and also in creating value for customers. However, in the implementation of this strategy, businesses need to make foresight and planning for how long they can maintain their position. In this case, the primary issue is to integrate the blue ocean strategy within the intrapreneurship relationship. In the markets that adopt the red ocean strategy, all competing businesses have intense efforts to win for the same business, while in the blue ocean strategy, there is a free market structure where the players are the same but different markets are located, rather than intense competition, aimed at creating innovation and benefit. The more unique, inimitable and inaccessible to the competitors, the higher the gains of the enterprises and the longer their lifespan will be. An intrapreneur is a person charged with generating and/or developing new ideas within the business. Today, it is seen that the popularity and benefits of intrapreneurship activities are increasing. In order to enter the blue oceans, which is an important factor for businesses to expand into new areas and increase profit maximization, it is very important for business management to create a policy to support intrapreneurship activities, as well as to create a new organizational culture that will support intrapreneurship. The success of the blue ocean strategy, which makes a difference in establishing the basis of the business strategy and providing competitive advantage, depends on the innovation-oriented, entrepreneurial culture of business managers. The aim of this study is to examine the "Blue Ocean Strategy", which is an alternative model in value creation, and the effects of intrapreneurship activities in businesses on this strategy in a conceptual framework.


in the directory pub/machine-learning-databases. The predictive sample reuse method with applications. 19 each one taking on the value 1 for one of the original values and the value 0 for the others. Annealing The data set used here is the result of concatenating the les anneal.data and anneal.test in the UCI repository. Missing values indicated by a question mark were treated specially by C4.5 and C4.5rules; for BP these were simply considered an additional discrete value. Image The data set used is the result of concatenating the les segmenta-tion.data and segmentation.test in the UCI repository. Sonar The data set used is from the le sonar.all-data in the UCI repository. Vowels This data consists of measurements of 15 speakers repeating 11 vowel sounds 6 times each. Originally, neural networks were used to classify utterances of the last 7 speakers on the basis of experience with the rst 8. Here the 990 (= 15 116) utterances are divided at random into training and test sets. 18 vectors to classes. Thus schemes for combining models, however sophisticated , amount to xed mappings from training sets to the same kind predic-tive models produced by simpler methods and are no less instantiations of bias. Whether combination methods will perform better than simple cross-validation or even the application of a single constituent strategy depends on the mix of problems to be encountered. 6 Acknowledgments Thanks to Sholom Weiss for helping me to understand the merits of cross-validation. Thanks also to Lori Pratt, who provided my copy of BP and extensive tutorial advice on how to use it, and to Ross Quinlan, who provided C4.5. All data was transformed in three ways for use by BP. Continuous variables were scaled (linearly) to the range 0,1]. Binary discrete variables|including the class variable for Sonar|were coded using a single variable taking on the values 0 and 1. Multivalued discrete variables|including the class variables for problems other than Sonar|were replaced with a set of binary variables, 17 Statisticians appear not to have directly addressed the question of the risk protection aaorded by cross-validation and its dependence on the number and diversity of constituent strategies. They have, however, undertaken in-depth analyses of other aspects of cross-validation. The theoretical relationship between cross-validation and related methods, including boot-strapping, is discussed in (Efron, 1982); Stone (1977) gives results on the performance of cross-validation in the long run, as the number of training cases approaches …


The significance of the Root-seeking Literature to the New Period Literature as a whole is great and far-reaching.It is a collective appearance of youth writers as well as a connection to the race narration. Though there is a distance between its original purpose and its cultural content and aesthetics,from modernist perspective,it has its own spiritual contents and value in literary history.


This paper examines the prescriptions for multi-headed representations of śaiva deities, in particular of yoginīs and Bhairavas, in early tantric or āgamic literature. Multi-headed deities appear mostly in the prescriptions of mantra images, usually without any discussion of their material representation. The paper shows that the four-faced mantric representation of Śiva, Bhairava and other divine creatures precedes the five-headed one, as is observable in epic literature and in art history. The fifth head is associated with tantric or āgamic śaivism, whose supreme deity is the five-headed Sadāśiva. As the five-headed mantra image becomes the standard, texts are rewritten to conform to this norm. Moreover, female deities are also often assimilated to this god and can be assigned four or five heads depending on the context. It is suggested as a hypothesis that the four-faced Śiva, or rather Īśvara, was perhaps adopted from the proto-tantric currents of the Atimārga (or from one particular current), from a representation whose Eastern or frontal face represented Śiva as half man, half woman (ardhanārīśvara).


This thesis was conducted during the author's first year of a three-year PhD program at the IICSE University, USA. The thesis had its focus on exploring impacting factors and behaviors of product brand recommenders in relation to customer loyalty, which is an unexplored field of research in Thailand. Most research studies in Thailand focus on brand loyalty of end-customers, none has explored loyalty behaviors of product brand recommenders or product brand endorsers. Product brand recommenders/endorsers are those who recommend or endorse specific product brand(s) to potential end users and/or customers. Product brand recommenders might or might not be direct product brand users by nature.
Quantitative research methods were mainly used in this dissertation research. A case study of customer loyalty behaviors of infant formula brand recommenders was explored in detail. Primary survey pen-and-paper based questionnaire and the interviews were the major information sources of the empirical data for the research, complemented with secondary data sources where relevant. The theoretical framework aims to find knowledge for compiling the main elements of customer loyalty behaviors of product brand recommenders in this thesis. The results of the thesis were customer loyalty model developed for brand recommenders of any product.


Mutations in isocitrate dehydrogenase 1 and 2 (IDH1, IDH2) have been described in low-grade glioma and in acute myeloid leukemia. Accumulation of the oncometabolite D-2-hydroxyglutaric acid (2HG) and its release into the blood is associated with dilated cardiomyopathy. The mechanisms leading to changes in cardiac metabolism and contractile function are unknown. We studied in the isolated working rat heart preparation metabolic consequences of increased 2HG supply and its impact on cardiac energy provision. In combination with physiological levels of glucose (5mM) and lactate (0.5mM), hearts were perfused at different concentrations with 2HG (0.5mM, 1.0mM). We confirmed the uptake and enrichment of 2HG in the tissue through liquid chromatography followed by mass spectrometry (LC/MS). 2HG markedly decreased cardiac power and cardiac efficiency in a concentration dependent manner. At the same time glucose oxidation increased significantly (1.4±0.1 μmol/min/g dry wt, p<0.05) at higher workloads. The alpha-Ket...


A batch of natural atmospheric dust samples collected in Beijing and the northern regions to Beijing in the different seasons were analyzed by X-ray power diffraction to study their mineral composition characteristics and their temporal-spatial distribution.The results showed that Quartz is the main mineral with an average content of 83.19% and that the main Feldspar is Plagioclase,indicating the weakly weathering process of the dust source region.Calcite and dolomite are the main carbonate minerals,representing comparability with the Chinese loess.The dust contains a small amount of clay minerals,1.64%-5.88% of the total mineral mass.Kaolinite is the main content of the clay mineral reflects the semi——wetness,relatively mildness surface environment of the study areas.Clustering analysis indicated that the sampling sites can be classified into two groups(urban and rural)according to the mineral composition characteristics.The dust samples collected in windy months possess relatively higher amount of clay and lower amount of Feldspar than those collected windless months.


This paper presents study of the rheological characteristics of the melt of the fish and vegetable mixture biopolymer in the pre-die zone of a single-screw extruder. The analysis of the flow index, being less than one, and that of the flow curves of the fish and vegetable mixture biopolymer melt, intended for production of expanded potato snacks, showed that the melt in a certain range of deformation rates can be attributed to pseudoplastic fluids. The results of the study represent important data in the design of the extruders molding units, on which the stability of the finished products quality depends. The results of the study can be used for mathematical modelling of the flow of the biopolymer melt in the pre-die zone of the extruder and can serve as justification of the screw rotational speed range in order to obtain extrusion foodstuffs of stably high quality.


Acmaeopleura hichiro, new species, a crab of the family Varunidae (Brachyura: Grapsoidea) is described from the Middle Miocene Kukinaga Group in Tanegashima, Japan. Recognition of this species extends the geologic range for the genus back to the middle Miocene. There is a possibility that Acmaeopleura hichirowas a co-habitant of burrows of Upogebia tanegashimensisKarasawa and Inoue (Decapoda: Thalassinidea).


In order to obtain the applicability of rectification method of subsidence on strip mining in flat seam,the accuracy of the method affected by the factors such as recovery rate,penal width,and mining depth is studied.Using UDEC discrete element simulation software and based on the subsidence survey data obtained when the surface of each first two extracted strip panels become stable after subsidence,we predicted the subsidence value of the following un-extracted panels by a specific way of shifting and superimposing.The result shows that in the case of which the recovery rate is 38.5%,45.5% or 55.6%,the panel width is 45 m,60 m or 75 m,and the mining depth is 400 m or 600 m,the predicted subsidence curves of the following 5 un-extracted panels are generally the same as the simulated ones.The error analysis verified that the method can well and truly predict the subsidence data and be popularized to other coal mines.


Author Nhi Mai Ho Title Capitalizing on The Future Growth of the eSports Industry: Tencent Ltd Case Study Year 2021 Language English Pages 62 Name of Supervisor Thomas Sabel This thesis aims to analyse electronic sports or eSports one of the world's fastest growing phenomenal in terms of public recognition and capital gain. An overview of eSports is provided in the first and second chapters with details regarding its historical development and formation. Several questions about the establishment of electronic sports, its association to traditional sports and gaming are addressed in this part. From the third chapter onwards, the thesis concentrates on analysing eSports as a young industry. By going through eSports development, economics impacts, investments, and its ecosystem; evidences supporting eSports maturity as an industry are presented. At the end of chapter five, eSports status as a nascent industry is established, along with footing data that points towards an explosive multi billionaire industry in upcoming years. In chapter sixth, a theoretical framework is presented. In this part, eSports is evaluated from economics perspective rather than financial figures and popularity. The definition of a nascent industry is provided, comes along with analytical measurement in terms of revenue, demand, investment diversification. Then, the compound annual growth (CAGR) is calculated, which the result supports the conclusion of eSports maturity given in the previous chapters. In the second part of this chapter, the Strategy Diamond framework written by Donald Hambrick and


Intercultures play an important role in localization of translation. They are the essential reference resources for those who are translators as well as writers in their literary translation or creation. Translators contribute to the extension of source culture and in target culture by means of intercultures to form new localized cultural paradigms. Bing Xin' s creation of the short free verse in the vernacular Chinese was influenced by Hu shih's new literature ideas and Zheng Zhenduo's translation of Stray Birds, a famous poetry anthology of Tagore. Through her translation, she borrowed new literary paradigms from foreign languages and successfully converted them into more acceptable ones in Chinese new literature. The paper, from the perspectives of Localization and Intercultures by Anthony Pym, explores the effects which Hu Shih and Zheng Zhenduo made upon Bing Xin's poetry translation and creation in the trend of poetry localization in the May Fourth Movement, and analyzes the interactions between Bing Xin's poetry creation and her poetry translation.


Fault simulation of digital circuits must correctly compute fault coverage to assess test and product quality. In case of unknown values (X-values), fault simulation is pessimistic and underestimates actual fault coverage, resulting in increased test time and data volume, as well as higher overhead for design-for-test. This work proposes a novel algorithm to determine fault coverage with significantly increased accuracy, offering increased fault coverage at no cost, or the reduction of test costs for the targeted coverage. The algorithm is compared to related work and evaluated on benchmark and industrial circuits.


A functional integral formulation, used previously to calculate T{sub c} and describe normal state properties of the BCS-Bose crossover, is extended to T{lt}T{sub c}. The saddle point approximation is shown to be qualitatively correct for T{lt}T{sub c} for {ital all} couplings, in contrast to the situation above T{sub c}. Several features of the crossover are described. The difference between the T=0 {open_quotes}pair size{close_quotes} and the (prefactor of the T dependent) Ginzburg-Landau coherence length is pointed out: the two quantities are the same only in the BCS limit. The evolution of the collective modes from the BCS to the Bose regime is discussed together with the mixing of the amplitude and phase in the absence of a particle-hole symmetry. {copyright} {ital 1997} {ital The American Physical Society}


An approach for computing efficiently monostatic and/or bistatic radar cross section (RCS) of complex targets considering multiple bounces is presented. The approach is based on physical optics (PO), the equivalent currents method (ECM), geometrical optics (GO) and a new ray-tracing accelerating algorithm. The new tool is very efficient and save memory and resources computing the RCS considering different iterations. Monostatic or bistatic RCS of complex targets modelled by planar or parametric surfaces can be obtained. The program has its own facility to generate or modify an existing geometry.


At recent years whiteboard has become a crucial element at almost every educational institute. They are large in size, for that reason it is very time consuming and tedious process to erase the writings from the board with duster manually. It breaks concentration of both lecturers and listeners. Automatic Whiteboard Cleaner can solve these problems. Automatic whiteboard cleaner will reduce the time and also the effort. This paper represents the design and construction of automatic whiteboard cleaner. The system consists of Arduino, relay, dc gear motor, supports and a cleaner bar to give that an automation figure. When the switch is on, it moves across the full width of the board and its direction is reversed automatically in order to clean the board. So, this "Automatic Whiteboard Cleaner" is a great replacement of "duster" and it can be suggested to use this to reduce the effort of the board user as well as to introduce the classroom with an automation system.


Over the past few years, wind power witnesses a continuous growing share in the conventional generation mix for its advantages in low-carbon and sustain. However, due to the randomness of wind energy, the integration of suburban wind farms into the urban power grid challenges the system operating safety. Due to the independent control ability of the active power and reactive power, modular multilevel converter based HVDC (MMC-HVDC) technology has become a good option for integrating the suburban wind farm into the urban power grid. Compared to the traditional AC transmission technology, MMC- HVDC could provide dynamic reactive power support to the urban power grid besides its excellent active power controllability, which could bring both control and stability benefit to the urban power grid. In this paper, a dynamic reactive power control scheme is proposed for the MMC-HVDC system integrating the suburban wind farm into the urban power grid. The proposed control provides different reactive power supports strategies for different operating conditions of the urban power grid. In addition, the proposed control could also realize fast and smoothly switch between different control scenarios of urban power grid dispatching instruction and emergency events so that providing effective reactive power support for the urban power grid. The small-signal model is also established in this paper for evaluating the stability of the dynamic droop coefficient. With the simulation results, the proposed control scheme is proved that this scheme can better support the voltage of the urban power grid.


Rh(III)-catalyzed C-3 selective alkenylation of pyridine derivatives via hydroarylation of alkynes has been developed. The reaction shows high regioselectivity, high yield and good functional group tolerance, providing a convenient strategy for the synthesis of trisubstituted (pyridin-3-yl)alkenes.


The chip-hat-shaped specimen of 30CrMnSiA was used to study the dynamic shear behavior by the Split Hopkinson Pressure Bar(SHPB).The microstructure evolution of adiabatic shear band was investigated by means of optical microscopy(OM),scanning electron microscopy(SEM),transmission electron microscopy(TEM) and microhardness.It is found that the deformation band changes to the transformation band with the loading strain rate increasing.The transformation band is a "white" band,which consists of a number of equiaxed grains about 50 nm in diameters with low dislocation density,and these grains have typical recrystallized character.The microstructure evolution can be grouped into four stages: shear deformation,grains refinement,grains fracture and rotation stage,and dynamic recrystallization.


Abstract. Kasmiyati S, Kristiani EBE, Herawati MM, Rondonuwu FS. 2021. Exploring anticancer activity of wild and polyploid mutant of Artemisia cina.  Biodiversitas 22: 1227-1234. The research aims were to explore the anticancer compounds in wild type (W) and polyploid mutant (P) of Artemisia cina Berg ex Poljakov using NIR and compare their cytotoxicity and selectivity on WiDR colon cancer and HTB183 lung cancer cell lines and Vero normal cell line. The W was obtained from B2P2TOOT Tawangmangu, Indonesia while P was by inducing A. cina shoot culture with 100 mg/l colchicine for 48 hours. They were extracted with hexane using the soxhletation method for 6 hours. The anticancer compounds were detected using NIR. The cytotoxic activity was determined using MTT assay, with Doxorubicin (D) as a control. The calculation of IC50 value used SPSS16 with a Probit analysis. The P contained the determined four compounds while the W contained no rutin. The IC50 values of W, P, and D were 295.5, 84.1, and 0.5 µg/mL on WiDr, 322.4, 128.6, and 39.9 µg/mL on HTB 183, whereas on Vero were 104, 315.6, and 295.5 µg/mL respectively. The selectivity indexes of W, P, and D were 34, 4, and 91 on WiDr, while HTB 183 was 31, 3, and 7, respectively. The P contained artemisinin, quercetin, kaemferol, and rutin, while the W contained no rutin. The cytotoxicity of both plants was less than doxorubicin. Both plants were selective on WiDR and HTB 183.


Objective To observe the protective effect of the eyes by different ways during spinal surgery in prone position. Methods 40 patients were randomly divided into A,B group.Group A,coat oculentum tetracyclini on patients' eyes with protection membrane,smear liquid paraffin on the places of compression and massage them,place the patients in the surgery position first and start the anesthesia.Patients received blood according blood loss intraoperatively.Group B,coat oculentum tetracyclini but not covered protection membrane on patients' eyes,anesthesia first then place the patients in the surgery position,patients received colloid according blood loss.Hemodynamics when the body position change or being anesthesia,the skin information and eye manifestation in all groups in the post operation day of 1,3,5 were observed. Results One with eye symptoms was found in group A and 5 in group B.The comparison of the incidence rate of eye symptoms was significant difference(P0.05).Steady hemodynamics when the body position change or being anesthesia,and satisfactory skin protection in group A than group B(P0.05). Conclusions The eye protection during spinal surgery in prone position are necessary.


ventilation and was transferred to the respiratory care center 3 weeks later. C. krusei was persistently isolated from the ascites and blood cultures, despite 25 days of fluconazole treatment. Fluconazole was replaced with intravenous caspofungin. A loading dose of caspofungin 70 mg without premedication was administered. Immediately after the loading dose, transient erythematous macules developed BACKGROUND: Explicit measures of potentially inappropriate prescribing, such as the Beers criteria , have been assoc iated with risk for adverse drug events (AOEs). However. no such link has been established for actual inappropriate prescribing using implicit measures.


[1] The present volume, which celebrates the work of theorist Janet Schmalfeldt, is based on conference presentations made at a special session held by the Committee on the Status of Women (CSW) at the annual meeting of the Society for Music Theory (SMT) in Montréal in October 2009. Since celebrations are usually associated with particular events, dates or achievements, readers might be curious to know the occasion with which this celebratory collection of articles is associated—and may be surprised to discover the absence of such specific circumstances. An explanation of the genesis of the session and the conceptual framework in which it was developed will help to provide this context and to introduce the contents of the volume.


The determination of the chromosome number in sections or smears of the peanut plant (Arachis hypogaea L.) is rather difficult because of the small number of cells with polar view of metaphase plates and for the tendency of the peanut chromosomes to clump together. Several techniques were tried in order to overcome these difficulties. The best results were obtained with the following method:(a) pre-treatment of the root tips in a saturated solution of paradichlorobenzene at 16-20°C for 4-8 hours or in a 0,002 M solution of oxyquinoline at 16°C for 6-7 hours; (b) hydrolysis in acetic orcein (2% orcein in 70% acetic acid) and hydrochloric acid in the proportion of 9:1; (c) smear and staining in 1% acetic orcein in 45% acetic acid,Paradichlorobenzene and oxyquinoline produce the c-mitotic effect on the chromosomes of Arachis. Consequentely the number of cells at metaphase is greatly increased and the chromosomes appear shortened and scattered throghout the cell. This makes the countings very easy. Comments about the mode of action of paradichlorobenzene on Arachis chromosomes are made and a detailed schedule of the technique is presented.


Abstract This article examines the place of the Chinese House (c. 1748) at Shugborough, Staffordshire, within the context of the mid-eighteenth-century craze for chinoiserie architecture in British gardens, and within the longer history of Sino-British encounters more generally. Drawing on evidence from published and archival sources, it argues that the expression of imperial ideology manifest in the garden at Shugborough represents an exceptional case for the period, during which more nuanced and ambivalent attitudes towards Britain's expanding presence in Asia generally prevailed. Attention is drawn to the need to locate the specific social settings of art objects within their wider historical contexts.


Enlarged gastric folds are infrequently encountered at endoscopy. A variety of conditions such as hypertrophic gastropathy, malignancies, infiltrative diseases or infections can lead to gastric fold enlargement. Their gross appearance may be similar. In this article, we will present a patient with enlarged gastric folds and a management dilemma.


We demonstrate 25 and 50 Gb/s four-level pulse amplitude modulation (PAM-4) transmission over 43- and 21-km standard single-mode fiber (SMF), respectively, using a silicon photonic 120° hybrid-based integrated simplified coherent receiver in the <inline-formula> <tex-math notation="LaTeX">$C$ </tex-math></inline-formula>-band. The integrated receiver is composed of an edge coupler, a vertical grating coupler, a polarization splitter–rotator, a <inline-formula> <tex-math notation="LaTeX">$3\times 3$ </tex-math></inline-formula> multimode interference coupler-based 120° hybrid, and three germanium p-i-n photodetectors. For 25 Gb/s PAM-4 transmission, we achieved the receiver sensitivities of −18, −17.5, −16.6, −14.5, and −9.8 dBm in back-to-back (B2B) and after 10.5, 21, 31, and 43 km, respectively, at a bit error rate (BER) below the hard-decision forward error correction (HD-FEC) threshold (i.e., <inline-formula> <tex-math notation="LaTeX">$3.8\times 10^{-3}$ </tex-math></inline-formula>) without using any receiver equalizer, while for the 50 Gb/s PAM-4 transmission, the receiver sensitivities of −13.6 dBm in B2B, and −13.5 and −11.6 dBm after 10.5 and 21 km are obtained using a 31-tap linear feed-forward equalizer (FFE), respectively. Furthermore, we achieved up to 44 Gb/s receiver equalizer-free PAM-4 transmission over 10.5 km below the HD-FEC. The characterization of the receiver at different wavelengths within the <inline-formula> <tex-math notation="LaTeX">$C$ </tex-math></inline-formula>-band is provided as well.


Digital infrastructure and learning algorithms, digital industry and automated services, digital society, humanities, and health converge with the Anthropocene. This mix has given birth to extraordinary challenges; for architecture as discipline, in its role as cultural heritage and as materialized co-evolution of man and machine. Despite of re-modelling and re-designing work-flows to integrate data necessary to arrive at a structurally and energetically 'good' piece of architecture, or rethinking an IoT (Internet of Things) supply chain management from planning via production to construction of a building or city and its performance monitoring, the digital has impacted our 20 century our long-standing relationship to architecture, technology and nature. This chapter suggests first ideas of a sixth ecology – influenced by Felix Guattari's "The Three Ecologies", Reyner Banham's "Theory and Design in the First Machine Age" and Benjamin Bratton's "The Stack". The Sixth Ecology describes one of and for a dynamic relationality across systems; multi-parametric, functionally adaptable, morphologically changing, cybernetic. One, where man, machine, technology and 'nature' merge – or speaking for architecture: designer and computer, builder and robot, planner and construction factory, construction site and biologically grown habitats. In 1958 Gilbert Simondon states that "culture has become a system of defence designed to safeguard man from technics. This is the result of the assumption that technical objects contain no human reality." 6, 7 Vaucason's 18 century automaton the defecating duck 9 describes a cornerstone for the beginnings of humanification of mechanical technical objects. The rise of digital technical objects since the 1980s and the disappearance of their atomic materiality in a wireless world describes a step further. Humanification of technology crosses the border of co-evolution and co-existence towards coalescence. My research on the 'sixth ecology' and concepts such as 'netgraft' and 'neurotecture' has been influences by the work conceived computational architecture studio Codes in the Clouds which I ran between 2009 and 2016 at DIA, Dessau International Graduate School of Architecture.


This paper presents a study of long‐term outdoor performance of a‐Si and hybrid modules mounted in the same location over several years. The modules were also characterized indoors using standard measurement methods employing pulsed solar simulators at the European Solar Test Installation (ESTI). The present study is intended to contribute to future standards on energy rating by presenting a common procedure for correcting the outdoor performance measurements to standard test conditions and comparing the resulting module performance at real and laboratory conditions. A seasonal variation in output, higher in the summer and lower in the winter, suggests that the module performance improves due to annealing when the module temperature is higher. The total output energy per month for these two technologies and a reference c‐Si technology is also presented. Copyright © 2010 John Wiley & Sons, Ltd.


Resumen es: >>>en: Natural enemies associated to Diaphorina citri in the state of Nayarit were identified. The study was carried out in three orchards of Persian lim...


Active vision represents a set of techniques that attempt to incorporate new visual data by employing camera motion. Object recognition is one of the main areas where active vision can be particularly beneficial. In cases where recognition is uncertain, new perspectives of an object can help in improving the quality of observation and potentially the recognition. A key question, however, is from where to look at the object. Current approaches mostly consider creating an occupancy grid of known object voxels or imagining the entire object shape and appearance to determine the next camera pose. Another current trend is to show every possible object view to the vision system during the training time. These methods typically require multiple observations or considerable training data and time to effectively function. In this paper, a next best view system is proposed that takes into account only the initial surface shape and appearance of the object, and subsequently determines the next camera pose. Therefore, it is a single-shot method without the need to have any specifically made dataset for the training. Experimental validations prove the feasibility of the proposed method in finding good viewpoints while showing significant improvements in recognition performance.


The magnetic field distribution in thick film permanent arrays micro - actuator was computed, and the influence of geometry parameter of permanent magnets on electromagnetic force of micro - actuator was studied. The results show height - to - width ratio of thick permanent magnet film and the gap between magnets can greatly influence the performance of micro - actuator. The numeric results indicate that height - to - width ratio of 0. 7 are reasonable.


This research aims to determine the effects of the leadership roles of administrators who work at special education schools upon organizational climate. This research has been conducted using the case study technique, which is a kind of qualitative research approach. The study group of this research consists of four administrators including three men and a woman who work in four different special education and rehabilitation centers in Sivas. The data have been collected by semi-structured interview technique. The data have been analyzed by the descriptive analysis technique. It can be suggested that participants mainly display the features of visionary leadership roles and they reflect this to teachers, students and parents.


EDITOR—Ind and Whitley, as well as other respondents to our paper on bmj.com, refer to the issue of our split sample design.1 Many such previous studies show that monolayers are superior to conventional smears (and were used to obtain approval from the Food and Drug Administration for ThinPreps). Now some who praised this design when it favoured monolayers are discovering that it is "flawed" or "faulty" when it gives the opposite results.

Our paper shows that the main issue for …


bstract—There is increasing concern about the neurodeenerative and behavioral consequences of ozone pollution n industrialized urban centers throughout the world and that omen may be more susceptible to brain neurodegenerative isorders. In the present study we have investigated the ffects of chronic (30 or 60 days) exposure to ozone on lfactory perception and memory and on levels of lipid perxidation, and estrogen receptors and dopamine -hyroxylase in the olfactory bulb in ovariectomized female rats. he ability of 17 -estradiol to prevent these effects was then ssessed. Results showed that ozone exposure for 30 or 60 ays impaired formation/retention of a selective olfactory ecognition memory 120 min after exposure to a juvenile timulus animal with the effect at 60 days being significantly reater than at 30 days. They also showed impaired speed in ocating a buried chocolate reward after 60 days of ozone xposure indicating some loss of olfactory perception. These unctional impairments could all be prevented by coincident stradiol treatment. In the olfactory bulb, levels of lipid perxidation were increased at both 30and 60-day time-points nd numbers of cells with immunohistochemical staining for and estrogen receptors, and dopamine -hydroxylase ere reduced as were and estrogen receptor protein evels. These effects were prevented by estradiol treatment. xidative stress damage caused by chronic exposure to zone does therefore impair olfactory perception and social ecognition memory and may do so by reducing noradreneric and estrogen receptor activity in the olfactory bulb. That hese effects can be prevented by estradiol treatment sugests increased susceptibility to neurodegenerative disorers in aging women may be contributed to by reduced esrogen levels post-menopause. © 2009 IBRO. Published by lsevier Ltd. All rights reserved.


The main objective of study is to propose application of advance blasting method in Malaysian shipbuilding industry; therefore it is hypothesis by replacing the current method with advance method would be more technically and economically beneficial. From the preliminary survey to the Malaysian shipbuilding or ship repair industry, the abrasive blasting methods are still being implemented for surface preparation. This technology, although effective in coating removal and establishment of surface profile, is laden with inherent problems, American and European yards began realizing the human and environmental consequences of open air abrasive blasting. To overcome such problem, the advanced method of ultra high pressure water jetting is used. However, this advanced ultra high pressure water jetting method is still not been implemented in Malaysian shipbuilding industry. With this back ground, a viability study was carrying out on the application advance blasting method to the local shipbuilding. The study focused on technical and economical aspects and comparison here made among several advance methods and against the present abrasive blasting method. The result of the study indicated that,
a. Technically, automated ultra high pressure water jetting is the best blasting method with the cleaning capability of 90 m2 per hour (12 times faster than abrasive blasting method) and equipped with external recovery system.
b. On the economic aspect, the automated ultra high pressure water jetting method is only economically viable if the amount of cleaning job per year is larger (more than 34,750 m2), while for small cleaning job, the present method review the most cost effective.


Summary A SQUID (Superconducting Quantum Intereference Device) rotating tensor gradiometer has been test flown in a helicopter-towed bird over a magnetic dipolar source. The bird was instrumented with fluxgates, tiltmeters, a gyroscope and GPS receivers to assist in levelling and positioning. After correcting for pitch, roll and yaw, the gradient tensor measurements along flight lines compare well with those calculated for the flight lines relative to the magnetic source. The uses and advantages in mineral exploration of magnetic tensor gradiometry have been discussed at previous ASEG meetings (2001 and 2004) and include the benefits of vector surveys without the disadvantage of extreme sensitivity to orientation, desirable mathematical properties of true potential fields (important in areas with strong anomalies), allowing rigorous continuation, RTP, magnetization mapping and redundancy of tensor components giving inherent error correction and noise estimates. A novel inversion/deconvolution procedure has been developed for locating and characterising dipole sources. Inversion using Euler deconvolution has been developed for locating a wider set of sources generally encountered in mineral exploration, such as spheres, sheets and pipes. A wide range of new types of processed data are available, including invariants, directional filters and depth slicing.


Abstract A middle ear effusion is a common complication of nasopharyngeal carcinoma both before and after radiotherapy. An effusion was found in 38 per cent of patients before radiotherapy and 9 per cent developed an effusion after the start of radiotherapy. Surgical treatment by myringotomy with or without grommet insertion was associated with a high incidence of otorrhoea (26 per cent) which was often refractory to treatment. In view of the frequency of this complication and the fact that a middle ear effusion may not be of concern to an adult patient with nasopharyngeal carcinoma, a 'wait and see' policy may be appropriate in the management of a middle ear effusion in these patients.


In this paper,we report the fabrication of Ni structures by electroplating a Ni layer on micro-machined PMMA, a typical resist material. This process involves following steps, (i) Spin coating a resist layer of 5 mum thick PMMA. (ii) Exposure by PBW of 1.7 MeV focused proton beam.(iii) Development of the PMMA with IPA-water (7:3) for 20 min and rinsed in deionized water [4]. (iv) Deposition of a seed layer of 40-nm thick Au by magnetron sputtering for electroplating on the surface of the micro-structure, (v) Electroplating of the micro-structure using a typical nickel sulfamate bath solution. The bath temperature was kept at 35 degC. (vi) Removal of the PMMA structure was made by immersion in acetone and the Ni structure was rinsed in ethanol. Therefore, the PBW is a promising tool for fabrication of metal components such as a stamp for imprint lithography. Imprinting using the 300-nm-thick Ni structure on PMMA was also demonstrated.


The traditional view on the origin of private property through labour considers that property is the result of a process whereby the "owned" inexplicably mixes with the "unowned" things. This paper aims at offering intellectual tools to draw up an alternative explanation. Private property would be licit only if it is originated through labour, that is, by means of productive and value-creating activities according to God purposes. The labourer is the object's "maker" from the materials that God provides him, similar to the usufructuary. It is also necessary to satisfy the non-spoilage limitation and that there is enough and as good quality left in common for others.


Review(s) of: These small glories, by Jon Cleary, (Angus and Robertson Ltd, Sydney, 1946, 6s.); Speaking for ourselves, Stories, Edited by Frank Sargeson, (The Caxton Press, Christchurch, N.Z., 1945.).


In order to contribute to the increasing inclusion of people who have been for a long time out of society, it is possible to construct accessible didactic material for specific audiences, such as for the elderly. This article aims to contribute to the area of accessibility by presenting recommendations for authors of didactic material that are not specialists in ICT in the construction of accessible material intended for this elderly public


I believe the idea of testing nurses' skills every three years is ridiculous (news February 2). Apart from it being totally unworkable, if nurses are not up to scratch, they can do a lot of damage in three years.


The principles of paraffin control in oil production wells are described briefly.Bacterial species AD-4,growing on solid wax and some inorganic salts,are chosen for this purpose.The bacterial population of AD-4 in the broth is of 10~8 cell/mL.Interaction of broth AD-4 with wax precipitates(WPs) from 9 wells at 65℃ over 7 days leads to depression of pour point of the WPs(27.5—55.0℃) by 1.5—8.5℃ and to decrease in pH value of the broth from 7.4 to 6.2—6.8 and in surface tension(71.0—76.1 mN/m) by 34.2—49.3%.For a crude oil interacted with the broth at 60℃ over 8 days,a decrement in heavy(C_(25)) paraffin fractions and an increment in light ones are observed,indicating that the bacterial species are hydrocarbon-degreding bacteria.In a pilot field trial covering 3 wells of Shuanghe reservoir and in an adaptive field trial covering 8 wells of Anpeng reservoir and 6 wells of Xiasanmen reservoir,it is established that the bacterial broth should be introduced to the well bottom through annulus together with the nutrients every 30 days in an amount of 300—450 kg per well at the first time and stepwise lowering down to 80—150 kg per well,the higher the reservoir tempeature the more the broth is to be used.The monitoring data of 5 wells show that the load and the current of the oil well pumps are lowered down and the period between two pump overhaul jobs—shortened.The bacteria AD-4 for waxing inhibition and precipitated wax removal can be used in production wells of water cut 30—90%,formation water total salinity 1×10~4 mg/L,and bottom temperature 90℃.


Pure molybdenum material was welded by means of vacuum electron beam welding,and the weld trait was analyzed too.Through analyzing the microstructure of welded joint with optical microscope,and comparing the each molten pool patterns under different welding parameters,the effect on weld trait of welding speed and welding current was discussed.The results indicate that the weld grains get very large with vacuum electron beam welding;welding speed and welding current are key factors to affect the weld penetration and depth-to-width ratio.


Jiang Zeming's "administering country by morality" is the basic strategy for the CCP to lead the people in bringing peace and order to the country. It is rich in content, including the role and place of morality in normalization, the placement of moral development on the level of "administering country", administering country with what "morality", the place of "administering country by morality" in building a socialist country ruled by law and comprehension of moral construction issues.