The problem of ethics may arise in any circumstances, at all times and in all places. For it is an ever-present problem which confronts every individual at all stages of his career after the dawn of consciousness. It is not limited to any particular aspect or department of life; it concerns the whole life of every human being from the cradle to the grave. Its existence may not be consciously recognized, and generally the choice of right and wrong action is unaccompanied by reflection; but the problem begins to operate as soon as the development of character begins, and people are always deciding between good and evil, whether they look inside their minds or not. For the formation of character depends on the manner in which the problems of conduct or morals are solved by each individual for himself. If he solves them correctly, he becomes good; If he solves them badly, he sows in himself the seeds of evil. The general problem, moreover, is essentially the same for all, though in each particular case its specific nature may vary according to particular circumstances.


The new VLBI observing system (OCTAVE-DAS) have developed based on the VSI-H and VDIF specifications at NAOJ (National Astronomical Observatory of Japan). It consists of 1) a high speed 8-Gsps 3-bit RF direct ADC (OCTAD) enable us to acquire not only wide intermediate frequency but also radio frequency up to 50 GHz and have DBBC functions for VGOS (VLBI Global Observing System), 2) a converter (OCTAVIA and OCTAVIA2) between one 10 GigE port and four 2 Gbps input and output ports conformable to VSI-H, and 3) new recorders (OCTADISK, OCTADISK2 and VSREC) at a rate of 4.5 Gbps and above 8 Gbps and 4) Gbit realtime correlator (OCTACOR) and software correlator system (OCTACOR2) using GICO3 was developed by NICT. These OCTAVE-DAS are connected via 10 GigE network with VDIF and VSI specifications. These components have been used for VERA, JVN (Japanese VLBI network) and KJJVC (Korea-Japan Joint VLBI Correlator). This paper reports a three-year progress since the last General Assembly of the International Union of Radio Science.


Describes how, in the face of severe competition from home and abroad, a new production improvement system was implemented which improved quality, reduced lead times and cut work‐in‐process by 40 per cent at Mitsubishi Aluminium′s Fuji Plant. Discusses the implementation of the programme over a two year period. Summarizes the results. Concludes that the MAF Production Improvement System has laid the groundwork for the continuous improvement of goods and services.


Pulsed electric field (PEF)-treated milk (25.7 kV/cm for 34 μs after preheating to 55 °C and holding for 24 s) was microbiologically stable for 21 days at 4 °C, and similar to thermally treated milk (63 °C for 30 min or 73 °C for 15 s). Alkaline phosphatase inactivation was comparable after PEF (preheating followed by PEF) and both thermal treatments. PEF treatment initially reduced xanthine oxidase (30%) and plasmin (7%) activities, but after 21 days of refrigerated storage these activities were similar to the initial untreated milk. During refrigerated storage of PEF (preheating followed by PEF) and thermally treated milk, lipolytic activity increased and pH levels decreased.


Novel functional poly (aryl ether ketone)s bonded nonlinear optical chromophores (meso-tetrakis (4-hydroxyphenyl) porphyrin, THPP) with different backbone structures were synthesized and characterized using proton nuclear magnetic resonance, Fourier transform infrared, and ultraviolet–visible absorption spectra. Their optical properties were evaluated by nonlinear optical analyses and optical limiting (OL). The results showed that these polymers possessed good OL properties and large nonlinear optical (NLO) susceptibilities. All polymer films-containing THPP presented excellent thermal stability (>460°C). Polymers bonded with –CH3 to the backbone exhibited better performances in OL and NLO properties than those bonded with –CF3; however, the thermal stability of the former was slightly inferior. Backbone bonded with electron donating groups was conducive to the OL and NLO properties.


33Abstract The paper analyzes the works of Jewish American novelist Joseph Heller who presents the war-torn world of the twentieth century in a typically Kafkesque manner. Heller's first novel of the American counter culture catches the reader by surprise and forces him to find new strategies to confront a chaotic and changing reality. The linguistic and existential impasse of catch-22 created by Heller in the novel by the same name continues to reverberate with renewed intensity in the political and military world of modern America. Heller pursues the Catch-22 theme in later novels with more Jewish characters to show that their assimilation is not complete. His novels further reveal how the intellectual gridlock of contemporary America prevents individuals f rom becoming happy, independent from the choices they make. Issues of apostasy, ideology and angst continue to plague his protagonists in a confused and confusing world of American hegemony and control. Often comic, but successful, attempts at self-preservation become the central focus of Heller's works. Obviously Jewish-American Counter Culture in Joseph Heller


This paper describes the leech Helobdella robusta, which was collected from the Sacramento delta of California. This new species is generally similar to another species found in California, Helobdella triserialis, and the two were compared in detail. In the adult, we observed reliable differences in the relative dimensions of the body, the size of the dorsal papillae, the pattern of cutaneous pigmentation, and the structure of the gut. In the embryo, we observed differences in the appearance of the yolk platelets and the size of the adhesive gland. We also observed differences in the rate of embryonic development. All of these differences persist in breeding populations that have been maintained in the laboratory over many generations. Experimental studies indicate that H. robusta and H. triserialis have little or no proclivity for interbreeding, supporting their distinction as separate species.


Modern concepts of control systems with digital signal processors allow the implementation of time-consuming control algorithms in real-time, for example soft computing methods. The pap ...


With the development of Internet, more and more enterprises build up Enterprise Information Portal (EIP) to promote their business. Rolebased access control mechanics provides a good way to control the access to EIP. XML is a flexible language to describe the hiberarchy of roles. 


In many complex ionic oxides, such as perovskites, spinels and olivines, cations are often found to occupy structurally nonequivalent sites. Information on cation distributions and their temperature dependence is scarce. The kinetics of cation site-exchange have not been studied to any greater extend up to now despite the fact that cation site-exchange processes represent elementary atomic jumps contributing to cation diffusion in these complex structures. In cobalt-containing olivines, (CoxMg1−x)2SiO4, divalent cations occupy two nonequivalent octahedral sites, M1 and M2, with the preference of the Co ions on the smaller M1 site mainly due to the crystal field stabilization energy and the bonding nature of ions in the sites [1]. In spinels, cations are distributed on tetrahedrally and octahedrally coordinated sublattices. NiGa2O4 is a largely inverse spinel with about 90% of Ni in the octahedral sites [2]. We report here experimental studies on the kinetics of cation site-exchange in complex oxides of the olivine and spinel structures by means of the combination of siteand ion-selective optical relaxation spectroscopy and temperature-jump technique. Fig. 1 shows that the time evolution of optical absorbance, A, upon temperature jumps can be modelled using the kinetic equation


ABSTRACT When tourists buy souvenirs, their perception of generated value often draws the souvenir supplier's attention. However, little is known about the reasons that drive tourists' perceived value. With the aims of filling this gap, we examine the impact of tourist value co-creation, souvenir authenticity, and tourist psychological ownership on tourists' perceived value. The findings revealed that tourist value co-creation, souvenir authenticity, and tourist psychological ownership have positive effects on tourists' perceived value using a PLS-SEM model. Moreover, tourist psychological ownership and souvenir authenticity demonstrated a mediating role in the effect of tourist value co-creation on tourists' perceived value.


A measurement and automation platform that includes technologies such as Sensors Plug&Play, USB, and Ethernet allow users to get products to volume quickly and manufacture them efficiently, while still providing the flexibility to quickly adapt their data acquisition systems to test new product innovations.


A novel, accurate and precise RP-UFLC method for determination of darifenacin hydrobromide has been developed and validated. Separation was achieved on an Enable C 18 G column (250mm × 4.6mm i.d., 5μm) using methanol: 10mM TBAHS (60:40, v/v) as mobile phase at a flow rate of 1.2mL/min and photo diode array detection at 285nm. Linearity was observed in the concentration range of 1.0-200 μg/mL. The method was validated for accuracy, precision, stability, specificity, robustness and system suitability. Forced degradation was performed by using HCl, NaOH, H 2 O 2 , thermal and UV radiation. The method was used successfully for the determination of darifenacin hydrobromide in extended release tablet dosage form


The high-quality, additive-free wines, thriving vineyard landscapes and the cultural heritage of wine regions with substantial organic production constitute the main resource for many destinations of wine tourism. Tourists are increasingly interested in visiting unspoiled viticultural locations and consuming healthy wines, which encourage vintners to apply ecologically sustainable practices and expand their business with touristic facilities. As the environmental knowledge of wine-consumers increases, their changing attitudes influence the producers perceptions of the environmental policies, product structures, branding and marketing strategies of vintners. Sustainable consumption is based on a number of decision-making processes regarding the social responsibility of consumers. One possible opportunity of incorporating environmental responsibility in planning wine consumption and tourism is targeted marketing towards consumers interested in protecting the environment and reducing the ecological footprint. Organic viticulture seeks to create robust and healthy soils and vines through proactive vineyard management in order to foster resilience, biodiversity and balance in the healthy agro-ecosystems of vineyards, even accepting lower yields. We propose a holistic concept, which comprises organic production, cultural heritage, educative tourism, development of complex product structures and special marketing strategies for the viability of organic wine


A filter positioned in the gating system of the mould represents a hydraulic resistance that increases the overall resistance of the gating system to the flow of metal. In this way it reduces the flow capacity of the ingate and extends the pouring time. When considering the introduction of filtration, a number of foundries find the extension of pouring time to be a factor that poses technical difficulties. Not many data are available on the actual effect of filters on the pouring rate. Let us have a look at what the actual effect of filter is. The filter is an element that captures in the gating system the impurities borne by the flowing metal. These impurities are mainly non-metallic inclusions formed by slag or moulding mixture particles, oxide films or also metallic inclusions – usually nondissolved inoculant particles. These particles get captured on the filter input side or in the whole of its volume. According to thickness, there are flat filters (e.g. metallic


This paper develops a novel technique which uses charge sharing as a method to perform addition in memory arrays. DRAM cells are conventionally used as storage elements and their data read through charge sharing. In our approach, DRAM cells are used as arithmetic units, thus saving area and power consumption in system-on-silicon applications. An adder in DRAM is designed, and its HSPICE simulation results are presented to show the viability of the proposed scheme.


Fibrolamellar carcinoma of the liver is a distinct variant of hepatocellular carcinoma characterized by the lack of association with cirrhosis or other underlying liver diseases, as hepatitis B virus. The serum alpha-fetoprotein level is often not elevated, occuring typically in young patients. Distinction from conventional hepatocellular carcinoma is of clinical significance, because prognosis is far better due to higher ressecability and more indolent growth. We describe a case of a 26-year-old woman free of other liver diseases presenting with a large abdominal palpable mass. After ressection by vascular exclusion technique, the pathologic examination revealed fibrolamellar carcinoma. The former should not be confused with the hepatocellular carcinoma, since it is related with a more favorable prognosis.


Some 450 films helpful for instruction in physics, mostly at the college level, are listed by field. Addresses of distributors are given. Sources of information about domestic and foreign films are included.


Opportunistic routing (OR) is a new method of routing in wireless sensors networks schemes (WSN) which selects the nearest node to the target for data transmission.It uses the nature of the medium to spread information. Opportunistic routing has been proven as promising routing technique for wireless sensors networks it also increases their reliability and efficiency and effectively supports multiple simultaneous flows by using the right OR protocols. The main idea behind OR is overhearing and cooperation between the nodes. This paper reviews the basic concepts of OR and lists all it protocols.


A magnetic momentum analyzer, called DCBA (Drift Chamber Beta-ray Analyzer), is being developed at KEK in order to search for neutrinoless double beta decay events. Since DCBA includes new techniques, a test apparatus, DCBA-T, has been constructed and operated for confirming technical feasibility. Preliminary results of the test operation are described together with future prospects.


Twelve laboratories of the Technical Committee 56 MHM "Hydro-carbon Materials" carried out precise determination of viscosity measurements performed with the following types of viscometers (falling ball, sliding plate, outflow, capillary, rotational) with the testing temperature range 30 - 160 degrees C. Only one type of bitumen (penetration 25 C 93 mm/10) has been analyzed. According to this investigation the precision of the capillary viscometer is slightly higher than that of the rotational one which precision decreases with increasing test temperature in the range 60-135 C. The measured precisions at 60, 100 nad 135 C either with capillary or rotational viscometers appear reasonable in comparison with precision criteria given in the literature. (TRRL)


The callus was induced from scutellum of mature embryo of rice(Oryza sativa L.),Then it was subcultured and differentiated properly and studied on the formation of competence and determination.Genotypes played a big role on induction,subculture and differentiation of rice callus.The trend of differentiation competence of rice callus took on down→up→slowly down on subculture.The differentiation competence of the first generation H41 callus kept falling down alone the days passing.When the first generation callus of H41 was transferred into differentiation media after cultured 17d on induction media,the determination could be formed at least inducing 2d on regeneration media.The determination of all the callus could not be formed at the same time because the competence of callus was different.


Transforaminal lumbar interbody fusion (TLIF) is a popular, well established technique for achieving circumferential fusion by a posterior approach. In an effort to minimize surgical approach-related morbidity, surgeons have devised minimally invasive (MIS) techniques that use specialized retractor systems, using muscle-splitting exposure, to provide surgical access directly over the region of interest. The indications for performing a MIS TLIF are similar to the conventional TLIF and include low-grade spondylolisthesis, degenerative disc disease with back pain with or without radiculopathy, and recurrent disc herniations. The surgical indications, contraindications, and an overview of the surgical technique are presented in this review. A systematic literature review was also undertaken to identify studies that compared MIS TLIF with open TLIF. The search revealed 8 controlled cohort studies that have shown significantly lower postoperative morbidity in the MIS TLIF cohorts while having comparable clinical outcomes with open TLIF cohorts. The higher complication rate during the learning curve of this procedure remains a concern. However, the evidence available is of low quality, and well designed prospective controlled trials are needed to decisively prove the benefits observed so far.


This article offers a detailed discussion of the Optag project, a study conducted in 2004 and funded by the European Union. The study is designed to assess the feasibility of combining Radio Frequency Identification (RFID) tag passenger locations with video surveillance systems to move large numbers of people efficiently and safely through the increasingly complex environment of major airports. The author notes that advantages of an integrated system combining RFID with video surveillance would include controlled entry to secure locations; precise automated tracking, particularly on certain individuals where prior intelligence has indicated a possible security threat; building evacuation help in case of emergencies such as fire, where poor visibility would be a factor; rapid location of lost children or of passengers who fail to arrive on time at departure gates. The author discusses the technical aspects surrounding the implementation of Optag, as well as potential challenges such as public opposition due to privacy concerns.


BACKGROUND
The aim of this study was to assess the changes of hemodynamic and oxyphoretic parameters induced by pneumoperitoneum in a series of patients undergoing laparoscopic cholecystectomy, by using the transesophageal Doppler ultrasonography (TEDU).

METHODS

DESIGN
prospective study.

SETTING
a medico-surgical intensive care unit of an University Hospital.

PATIENTS
11 patients who underwent laparoscopic cholecystectomy because of gallbladder stones.

INTERVENTIONS
a central venous line, a radial artery line were placed before the induction of anesthesia. End expiratory CO2 (EtCO2) was monitored by using a capnometer (Dräger, Germany). Cardiac output (CO) was measured using the transesophageal Doppler system Abbott ODM II (Abbott Critical Care Systems, Ireland), which was positioned in the esophagus after stabilization of anesthesia.

MEASUREMENTS
hemodynamic parameters, including CO, central venous pressure, mean arterial pressure, measurement of EtCO2 and arterial and central venous samples were performed: after reaching a stable anesthesia but before any surgical manipulation (T0); after induction of pneumoperitoneum (T1); 15 min after T1 (T2); 30 min after T1 (T3).

RESULTS
SVR increased significantly at T1 and T2 compared to T0; PaCO2 and PvCO2 at T2 and T3. HR and MAP increased significantly at T1, and CVP significantly at all the times.

CONCLUSIONS
Laparoscopic surgery is a mini-invasive technique of increasing success among both surgeons and patients. The widening of candidate patients raises the question of eligibility for individuals with known cardiopulmonary disease. In these patients, only a careful and thorough anesthesiologic monitoring allows the prompt identification and treatment of any relevant hemodynamic and/or ventilatory changes.


A novel cis-AB variant allele arising from a nucleotide substitution A796C in the B transferase gene Cis-AB is a rare phenotype of the ABO blood group system.1 Serologically, it is characterized by the presence of A, weakened B, and elevated H antigens on the RBCs. A nonautoanti-B is usually detected in the serum. Of the studies that have reported the nucleotide (nt) sequence of the cisAB allele, all have demonstrated an A allele bearing the G803C nt substitution characteristic of the B allele.2-4 This nt substitution results in the amino acid (aa) substitution, Gly268→Ala, at one of two critical positions for determining A/B-transferase specificity, with the other position being aa 266 encoded by nt 796.5 Here we report the identification of a novel cis-AB allele* that appears to have arisen from a single nt substitution at position 796 in the B-transferase gene. The propositus, a 37-year-old Vietnamese man, presented during routine blood grouping and screening for related-donor organ matching. By serologic typing, the propositus typed as A2Bweak with elevated H antigen on his RBCs, while a non-autoanti-B and a weak anti-A1 were detected in his serum. The father of the propositus also demonstrated this phenotype. Transfersase studies could not be conducted. The three siblings of the propositus all typed as group O. Thus, it was deduced that the A2Bweak phenotype of the father arose from a cis-AB allele that had been passed on to the propositus. To identify the genetic basis of this observation, molecular analysis was performed on all direct family members using PCR-sequence-specific oligonucleotide (SSO),6 PCR-restriction fragment length polymorphism (RFLP),7 and sequence analysis (the latter performed by two independent laboratories: Sequence Facility, Department of Microbiology, Monash University, Clayton, VIC, Australia; and Flinders University Automated DNA Sequencing Facility, Flinders Medical Centre, Bedford Park, SA, Australia). The ABO genotype of the mother of the propositus was found to be BO1v, and all the siblings of the propositus were O1vO1v. By PCR-RFLP, the propositus demonstrated B-allele specificity at nt positions 526 and 703, but not at 796, and O1v-allele specificity at nt positions 646 and 771. Sequence analysis of the region spanning nt 411-892 of exon 7 of both the propositus and the father confirmed the B-allele specificity at nt positions 526, 657, 703, and 803, but it also revealed a cytosine residue at nt 796, which is indicative of an A allele (Fig. 1). A final genotype of cis-ABvar/O1v was assigned to both persons: the nomenclature cis-ABvar is proposed to distinguish this variation from the gene configuration previously identified.2-4 Figure 2 shows the pedigree of the family. The data suggest that the cis-AB allele described in this study arose from a point mutation at nt 796 of a seemingly normal B allele. In this case, the mutation involved the substitution of the B-transferase-specific adenosine residue with an A-transferase-specific cytosine residue. An A796C substitution results in the aa substitution Met266→Leu, which changes the sugar donor specificity at that site to an A-transferase and could give rise to a bifunctional transferase, as is suggested by the serologic findings presented in this study. Other molecular mechanisms, such as recombination between A and B alleles, may also provide an ex* Footnote: The nucleotide sequence of this allele has been listed on GenBank, Accession Number AF062487. Fig. 1. The nt sequence analysis at and around nt 796 of exon 7 of the cis-ABvar allele. Cytosine (C) residue at nt 796 indicated by arrow. "N" at nt 803 signifies the presence of two nts, cytosine and guanosine, which are indicative of a B allele and an O1v allele, respectively.


The invention discloses a resource allocation method based on satellite cooperation. The method is characterized in that an inter-GEO link and a GEO-LEO link are modeled into an M/M/1 queue, and the relationship between two system parameters (system transmission delay and information source buffer queue size) and the distribution result of service flow among transmission satellites is established. According to the method, an optimized system objective function is obtained by adjusting the allocation plan, so that transmission rate limitation under the condition of single-link satellite communication is broken, the utilization rate of the satellite channel is increased, and the load of the satellite network is balanced while user data transmission rate is increased.


Reginator is a patented blend of nine essential amino acids, plus arginine, that has been shown to increase muscle synthesis.


Abstract Background The CDC estimates over 1.2 million Americans are living with HIV and, of those, approximately 14% are unaware of their HIV-positive status. Since 2014, most hospitals adopted some form of Electronic Health Records (EHR) and the Centers for Medicare & Medicaid Services extended Medicare coverage for annual HIV screenings. Despite these developments, there has been limited progress in expanding HIV testing in inpatient settings. The present study was conducted at Jersey City Medical Center (JCMC) in an effort to expand HIV testing by implementing EHR modification in the form of testing prompts. Methods This study began on January 1, 2016 at JCMC, a teaching hospital that passed all lab work orders through an EHR system. The number of daily orders for HIV screenings was recorded for 145 consecutive days before EHR modification (n = 145) to establish baseline data. EHR modification occurred on the 146th day of the study (May 25, 2016). This modification featured testing prompts displaying CDC guidelines for screening patients over the age of 18 for HIV whenever a physician ordered lab work for admitted patients. Orders for HIV screenings on this transitional date were excluded from analysis. After EHR modification was completed, the number of daily orders for HIV screenings was recorded for an additional 145 consecutive days (n = 145) for comparison. Testing data was available for all 145 consecutive days before and 145 consecutive days after EHR modification. Results Since the beginning of this study—before testing prompts were implemented—JCMC inpatient units ordered an average of 8.53 (SD=3.25) HIV screenings per day. The average number of daily orders for HIV screenings increased twofold after EHR modification (M=17.39, SD=4.26), t(288) = 19.90, P < .001. JCMC identified 86 HIV-positive and linked over 90% of these patients to care. Conclusion Conventional HIV screening methods in the inpatient setting might not be sufficient at detecting most HIV-positive cases. By implementing testing prompts in its EHR system to encourage increased testing for HIV, Jersey City Medical Center was able to increase the number of individuals aware of their HIV status and link them to care as needed. Disclosures T. Nguyen, Gilead FOCUS: Employee, Grant recipient


In the course of work on factor groups of the modular group, A. O. L. Atkin (private communication) obtained the permutations which satisfy the relations (1) for T = T1, T2. It was evident that neither pair S, T generates either A12 or LF(2, 11), so he suggested that they probably generate the Mathieu group M2.


Objectives: This study aimed to identify the impact of the functional classification of wheelchair basketball players on blood pressure values after sub-maximal exercise.
Methods: the researchers used semi-experimental method with all its procedures to achieve the study objectives. The study sample consisted of (8) players out of the (12) players representing the Jordan national wheelchair basketball team based on the records of the Jordan Paralympic Committee for years 2021, and the players were selected deliberately. The researchers used the semi-experimental method to achieve the study objectives. Moreover, the researchers used the VO2PEAK test and Borg scale of perceived severity statistically, the One Way ANOVA test and the LSD test were used, in addition to the arithmetic mean.
Results: The results showed a significant decrease in the value of diastolic blood pressure in the categories (1-1.5) and (2-2.5). This took place lower due to the nature of the disabilities falling under these two categories are according to the classification of wheelchair basketball players.
Conclusions: In light of the results, the researchers recommend taking into consideration the values of diastolic blood pressure when developing training programs, especially for players with amputations from the classification of amputations of the lower limbs above the knee.


Though Sun Chu is a famous scholar in early Western Jin dynasty,his Fu writings have rarely been mentioned. There are seventeen short Fu writings of Sun Chu in the Article of Jin Dynasties in Whole Article Collection of Remote Ages,Three Generations,Qin,Han,Three Kingdoms and Six Dynasties written by Yan Kejun. In this paper,the features of Sun Chu's Fu writings are studied in aspects of subject,length,allusion-using and fewer metaphor and contrast.


The following new findings and concepts are expected to lead to a better understanding of the role of surface preparation profile in coatings performance. Scanning electron microscopy and related techniques (especially in 3-D stereo) made it possible to visualize, for the first time, the true topography of structural steel surfaces cleaned by various methods and to reconstruct the probable mechanism of profile formation. Exposure tests still under way have already established important trends: abrasive size and profile height, within normal ranges, had a relatively minor effect on coatings performance; increasing the degree of surface preparation yielded diminishing returns; sand and other non-metallic blast media gave consistently good results. Primer thickness was very critical. These and other major variables (angle of impingement, oiliness, rolling direction, pre-rusting, steel thickness, etc.) are still the subject of continuing exposures. A proposed specification has been developed for a standard method of measuring profile by optical microscopy. An (h sub max) concept was developed ot inter-relate four good field methods which formerly had yielded wide discrepancies in measuring profile (visual comparator, depth age, magnetic gage, and replica tape/gage). Three additional methods were found to be especially effective in research studies: (microsections, stylus traces, and a triangulation technique), whereas four other approaches are of special future interest (surface volume, pneumatic, scratch gage, and light-section gage). The effects of the major surface preparation parameters on profile were established including type of abrasive, size of abrasive, degree of blast cleaning, type of equipment, angle of impingement, steel thickness, peak count, and steel variation.


hen Betty Hasselkus (immediate past AJOT editor) asked us to be guest editors on a special issue regarding families, we thought it was a great opportunity to examine the essence of families relative to occupation across the life span. After all, Ruth's expertise is pediatrics and Mary has built a career in aging. We feel our goal has been met, and exceeded, as we came to appreciate the variety of ways scholars are looking at the complexity of families, family occupations, and occupational therapy services that involve family members. Among these issues are:


This paper develops the concept of a contour of complete nonuniqueness and shows its application to the optimal design (optimal layout) of simple trusses transmitting a concentrated force to a presscribed, arbitrary foundation contour. As an example, a symmetric two-bar truss with compressed bars is considered, and the constraints refer to various kinds of elastic instability of the system.


DNA repari synthesis and chromosome aberrations induced by various concentrations of alkylating agents (MMS, MNNG, MMC) in cultured human lymphocytes and HeLa $S_3$ cells were studied to determine the possibility of correlation between these two types of biological phenomena, and the results obtained were as follows: DNA repair synthesis was detected in MMC, MNNG and MMS treated HeLa $S_3$ cells at the concentrations of $3 \\times 10^{-7}M, 1 \\times 10^{-6}M, 5 \\times 10^{-4}M$, respectively. These results indicate that MMC is the most potent mutagen followed by MNNG, and MMS is the least potent among these three types of alkylating agents. MMC and MNNG did not show any significant increases of DNA repair synthesis as dose increased, while MMS did. Chromosome aberrations induced by MMC in human lymphocytes was increased as dose increased, but not chromosome exchanges. MNNG did not induce any significant amount of chromosome aberrations with doses, and exchanges were not observed in MNNG treated cells. MMS, however, induced both chromosome aberrations and exchanges, and their rates were increased as dose increased. These results suggest that DNA repair synthesis induced by these alklating agents may not be directly related to the production of chromosome aberrations and exchanges.


In this paper, we build upon existing work and suggest an extension of the Haar Cascade face recognition algorithm in order to improve its accuracy and efficiency under varying lighting conditions. For doing so, we add a phase-preserving denoising method, which leads to a faster convergence of the classifier and improved face recognition efficiency. We evaluate the suggested approach by comparing the native Haar Cascade algorithm with our suggestion in terms of efficiency and accuracy within six different options for video filters, depending on varying lighting conditions i.e. broad daylight vs. dark environments. Analysis of results revealed that the suggested approach outperformed the native implementation in most evaluation scenarios and that the best filter options in broad daylight settings would be the No and the Gray filters, whereas in dark environments, the Gray and the Redish filters would be the best options. The Gray filter achieved top ratings in both lighting condition settings yet requires a higher computational cost for facial recognition.


An experimental study is performed to identify spatially coherent pressure waves, which would serve as precursors to the development of an instability in the Purdue Low-Speed Centrifugal Research Compressor when configured with a vaneless diffuser. To achieve this, sensitive electret microphones were uniformly distributed around the circumference in the inlet and diffuser sections of the compressor. Fourier analysis of simultaneously sampled data from these microphone arrays was employed to identify the development of dominant spatial modes in the pressure field in the compressor. The transition to stall was observed to be a gradual process, with the growth of the pressure waves into those corresponding to a large-scale stall condition occurring over a time span of 26 impeller revolutions. The excitation of the pressure waves, as indicated by spatial Fourier analysis, occurred 14 impeller revolutions before small changes were evident in the microphone signals, and 26 revolutions before the stall condition could be considered fully developed


Teenage pregnancy affects many teenagers and become a public health concern. The purpose of this research study is to identify the different environmental factors affecting early pregnancy among teenagers in selected Barangay of Echague Isabela. Descriptive-correlational study was conducted among selected teenagers at barangay X, Y and Z of Echague Isabela through non-probability convenience sampling technique. Questionnaire consist of 4 contributing factors; the economic factor, familial factor, peer-pressure factor and educational factor using the Likert scale. Data were gathered through online platforms and face-to-face. The result of the study reveals that there was no significant relationship between the factors that contribute to teenage pregnancy and their profile age, and educational status where C >0.05 on the analysis. There was no significant difference between the factors that contributed to teenage pregnancy when grouped according to their profile age, and educational status where the analysis shows F > 0.05. It indicates that the factors that contribute to teenage pregnancy is not affected by the respondents' age, and their educational status. It served as resources, to increase awareness and may provide information that could be useful for couples, students, health workers, teachers and parents.

Keywords: teenage pregnancy; factors; affects


Selected by in vitro techniques (SELEX, cell-SELEX), aptamers are strands of DNA or RNA 13 molecules able to bind a wide range of targets, from small molecules to live cells, and even tissues, 14 with high affinity and specificity. Due to their efficient targeting ability, aptamers are extensively 15 used in different fields of applications. For example, they ensure high performance as cancer-related 16 markers or in recognizing cancer cells. Actually, they represent a promising way for early diagnosis 17 (biosensors) and to deliver imaging agents and drugs, in both cancer imaging and therapy 18 (therapeutic aptamers). Aptamer-based biosensors (aptasensors) have attracted particular attention 19 over the last decades, so as the possibility of using aptamers in disease therapy in substitution of 20 monoclonal antibodies. The paper briefly reviews the most recent literature on this topic, both 21 concerning the advances in biomedical applications and in the development of electrical 22 aptasensors. The investigation concerning the bioelectronics features of aptamers, to be 23 implemented in the development of electrical nanobiosensors, is also reviewed. To this aim, some 24 recent results of a theoretical/computational framework for modelling the electrical properties of 25 biomolecules (Proteotronics) are reported. 26


Peak plasma densities in excess of 10/sup 15/ cm/sup -3/ have been obtained in the Alcator tokamak with 60 < or = B/sub T/ < 85 kG. The highest average density so far achieved is n-bar/sub e/ = 6 x 10/sup 14/ cm/sup -3/; the corresponding n/sub 0/tau/sub E/ = 2 x 10/sup 13/ cm/sup -3/ s. These ultrahigh-density discharges exhibit (i) nearly complete energy equilibration between electrons and ions, (ii) severe attenuation of energetic--neutral-particle fluxes ,(iii) a minor role of impurities, and (iv) energy-confinement properties consistent with neoclassical estimates.


Indeed the MS is very long, but the authors decided to join the results for the different soils and the technical part together since the results are needed to understand why the incubation system needed to be improved (see reply to referee #1). Thank you for the recommendation to join the result and discussion section and to shorten the conclusion section. We will modify that in the final version and will reduce the total length of the MS. The authors appreciate the evaluation of referee #2 to publish the technical part.


Gaming has played an important part in our daily lives for quite some time now. As a result, many researchers are interested in the various ways in which gaming has an impact beyond its own context. This dissertation explores one particular type of impact, i.e., the impact of gaming on organizations. It theorizes that gaming is a frame of mind that influences what we find important when it comes to communication and collaboration with our colleagues at work. To explore this further, this dissertation first develops the notion of 'playful organization'. Using a framework of organizational culture and structure, the dissertation tries to find playful organizations where online gamers play and work. It re-evaluates previous empirical studies of online gaming communities and professional organizations. It also looks into the 'corporations' of the massively multiplayer online game EVE Online, based on an ethnographic study. Finally, it looks into the communities and work organizations of a panel of Dutch online gamers, listening to the panelists' ideas about the extent of playful organization in both contexts and subsequent comparisons between the two. This dissertation is thus an interdisciplinary and in-depth organizational study of online gamers' communities and work organizations, in an attempt to gain insights into gaming's impact on organizations.


Summary The author has argued elsewhere for an increased role for linguistics and literary studies within environmental education. Here he argues that the tripartite division of literacy skills as functional, cultural and critical can be useful in both planning and evaluating programmes of environmental education. As exemplification of the latter, the model is applied to a brief discussion of the School Curriculum and Assessment Authority (SCAA) guidelines for environmental education in England. It is concluded that these offer opportunities for teachers to develop all three kinds of environmental literacy, but with an emphasis on skills development which must largely be seen as functional.


Preface and Acknowledgments.Introduction Popular culture/cultural citizenship.1 Ethnicity, football and the nation.2 Negotiating global popular culture.3 Conservative feminism and the detective novel.4 Masculinity and the merits of textual analysis as part of an audience study.5 Critical viewership.6 Children and media.7 Popular culture: a modern and a postmodern genealogy.Concluding remarks.References.Index


Labor Contract Law prescribes that the concluding of non-fixed-term labor contract with employees by employers is mandatory,which makes non-fixed-term labor contract possess functions of protecting employees and maintaining stable labor relations.However,in practice,employers tend to take various measures to avoid concluding non-fixed-term labor contract with employees and that makes the legislation intent impossible to be achieved.The legislation of labor contract should be established,with fixed-term labor contract being the supplementary,on the basis of the principle of concluding non-fixed-term labor contract.Meanwhile,with the simpler process of dissolution of labor contract coupled with improving unemployment insurance system,the harmony and stability of labor relations can be achieved ultimately.


As university research administrators weigh the challenges they will face in the future, misconduct in research undoubtedly looms large. At many universities, misconduct in research has garnered increasing amounts of time and expense. This paper suggests that these trends are unlikely to change in the near future, placing greater and greater pressure on university research administrators to deal responsibly and effectively with misconduct in research. This suggestion is based on the answers to four questions, followed by a listing of four responsibilities that all research universities should consider adopting. Note: Originally published on Research Management Review, 5 (2) (fall 1991), pp. 41-46. © National Council of University Research Administrators, 1991. Translated into Spanish by Carolina Carter for Paradigmas with permission of the copyright holders .


We report on the experimental demonstration of chirality-selective mechanical separation of randomly distributed assemblies of right-handed and left-handed chiral microparticles by optical means. Chiral-resolution experiments are made using two-dimensional emulsions of chiral-liquid-crystal droplets under the action of circularly polarized laser beams and do not require information on the initial location of the particles. Also, we numerically identify that the cooperative effects of hydrodynamic interactions mediated by the viscous fluid surrounding the particles can speed up the enantioseparation process.


for the congress CDROM. Submitted to and accepted for oral presentation on the 9 annual congress of the European College of Sport Science, Clermont-Ferrand, 3-6 July 2004


Eating nuts improves blood lipid levels in a dose-related manner, particularly among people with higher low-density lipoprotein cholesterol levels or with lower body mass index (BMI).


Abstract The particular modification of the angle type rotating ring abrasion machine as described in this paper can be used to obtain a figure for the over-all energy consumed in causing abrasion of rubber. The writer is undecided as to whether or not the energy which actually goes towards causing abrasion is a large enough percentage of the total over-all energy consumption to warrant any belief that the energy of abrasion has yet been measured.


Dijkstra [4, 5] introduced the problem of self-stabilization in distributed systems as an interesting exercise for achieving global convergence through local actions. In [4] he presented three solutions to a specific version of the self-stabilization problem, one of which was proved in [6]. This paper presents an alternative solution of his self-stabilization problem with four-state machines.


Alkoxysilane functionalized isocyanate based materials of low viscosity prepared by reacting in any possible order of addition an organic polyisocyanate with an isocyanate-reactive compound and an amino-functional alkoxysilane of formula I R-HN-R -Si-(OR )[3-x](R )x (I) wherein R represents a group with electron withdrawing properties, R is a linear of branched alkylene or arylene group, R and R are identical or different and each represent alkylene or arylene groups and x is 0, 1 or 2.


Surgery is the best way to treat liver cancer, automatic and precise segmentation of the liver from the patient's abdominal CT image plays an important role in guiding the surgical procedure. It is difficult to segment the liver, not only because of the similar grayscale values and the low contrast between the liver and surrounding organs, but also the quite different shape of the liver in CT images between different individuals. To address the above problems, an automatic liver segmentation network based on multi-scale feature fusion (MSFF-Net) was proposed. The model was based on the basic network structure of 3D U-Net. At first, the residual dilated convolution module was used to expand the receptive field and obtain multi-scale information. In addition, the residual attention module was used to fully fuse the multi-scale features in the upper and lower networks to improve the network's attention to the detailed information of the target region. Finally, a hybrid loss function was designed for the data label imbalance problem, which was combined with deep supervision to improve the segmentation effect. The ablation study was conducted on the public datasets LiTS 2017 and 3DIRCADb. The model has performed on the LiTS 2017 dataset, Dice per Case and Dice Global metrics are 0.963 and 0.964 with an increase of 3.4% and 3.1% higher compared with the baseline network respectively, and the remaining auxiliary evaluation metrics were also relatively high. The Dice per Case and Dice Global evaluation metrics on the 3DIRCADb dataset were 0.961 and 0.961 with an increase of 3.3% and 3.1% higher compared with the baseline network respectively, which further demonstrates the effectiveness and generalization ability of the proposed method.


Antibodies topurelysyl hydroxylase fromwholechick embryos wereprepared in rabbits andusedforimmunological characterization ofthisenzymeofcollagen biosynthesis. Indouble immunodiffusion asingle precipitation line wasseenbetween the antiserum andcrude orpurechick-embryo lysyl hydroxylase. Theantiserum effectively inhibited chick-embryo lysyl hydroxylase activity, whether measured withthe biologically prepared protocollagen substrate orasynthetic peptide consisting ofonly 12aminoacids. Thissuggests that theantigenic determinant waslocated neartheactive site oftheenzymemolecule. Essentially identical amountsoftheantiserum were required for40%inhibition ofthesameamountoflysyl hydroxylase activity units from different chick-embryo tissues synthesizing various genetically distinct collagen types. In double immunodiffusion a single precipitation line ofcomplete identity wasfound between theantiserum andthepurified enzymefromwhole chick embryos andthecrude enzymes fromchick-embryo tendon, cartilage andkidneys. These results donotsupport thehypothesis thatlysyl hydroxylase hascollagen-type-specific ortissue-specific isoenzymes withmarkedly different specific activities orimmunological properties. The antibodies tochick-embryo lysyl hydroxylase showed aconsiderable degree ofspecies specificity whenexamined either byactivity-inhibit ion assayorbydouble immunodiffusion. Nevertheless, adistinct, although weak,cross-reactivity wasfound between thechick-embryo enzymeandthose fromall mammalian tissues tested. Theantiserum showedno cross-reactivity against prolyl 3-hydroxylase, hydroxylysyl galactosyltransferase orgalactosylhydroxylysyl glucosyltransferase inactivity-inhibit ion assays, whereas adistinct cross-reactivity wasfoundagainst prolyl 4-hydroxylase. Furthermore,antiserum topureprolyl 4-hydroxylase inhibited lysyl hydroxylase activity. These findings suggest thatthere arestructural similarities between these twoenzymes, possibly close toorattheir active sites.


Directed crystallization is found in many natural systems, where the inorganic material provides the organism with superior barrier and mechanical properties. Using this principle of controlled nucleation and growth on a biopolymer (pectin) substrate, hollow shells of calcium carbonate were formed in certain reaction conditions that were generally more perfect at lower reactant concentrations. The nucleation mechanism required the presence of calcium-binding acidic groups on the biopolymer. These served to initially gel the biopolymer, thus providing the template upon which crystallization could occur, and then provided the calcium-rich sites at the template surface that promoted crystallization. The propensity of the system to crystallize on the gel particle surface thereby led to the formation of a complete shell of calcium carbonate, in the form of calcite, which in certain conditions was shown to effectively encapsulate small molecular weight hydrophilic species such as sodium chloride. Importantly, h...


Some industries are populated primarily by diversified firms, while other industries are dominated by specialized firms, which are present only in such a given industry. In this study, we analyze what factors determine the dominance of diversified versus specialized firms, and its effect on firm performance. In line with transaction cost economics, we show that market concentration and the degree of variability in the diversification pattern of firms in the industry are negatively associated with the importance of the activity accounted by specialized firms across the 720 industries in our study.


· Posterior Circulation Two vertebral arteries originate from the first part of the subclavian arteries. These join intra-cranially to form the basilar artery and supply the posterior cerebral circulation. This is the main blood supply to the brain stem, cerebellum and posterior cerebrum. · Anterior Circulation Both internal carotid arteries arise from the carotid bifurcation in the neck. Intra-cranially, the internal carotid arteries form the middle cerebral arteries, the most important branches in the anterior cerebral circulation.


Responses of a freshwater pulmonate snail Lymnae aluteola L. to copper, cadmium and mercury were observed at four temperatures in the range of 15.0 oC to 30.0 oC. Acute static bioassays were carried out at 15.0 oC, 20.0 oC, 25.0 oC and 30.0 oC to determine the percent mortality and median lethal concentrations (LC50) and their 95 percent confidence limits. The acute toxicity of mercury, copper and mercury increased with the increase of temperature from 15oCto 30oC. The 96 h LC50 values and percent mortality indicate that metals at 15oCwas least toxic while at 30oC it was highly toxic.


Abstract The author traces factors which renders the history of psychoanalysis difficult to explicate: gaps in the historical sources such as incomplete publications of Freud's correspondence, lacking material from the patient's viewpoint and from other members of the organisation. Available sources have been selectively used, so that Freud's writing has been dissociated from the history of the movement. Some of the items outlined and discussed by the author in an overview of the history are the following: The transition from an early aim of capturing "true causes" to a more restricted "applied psychology". The interruption through the first World War and the splitting up of "the Movement" in national versions. The attempt to incorporate psychoanalysis as "German psychology" during Hitler's regime—with great success in the German army shortly before the war. The apaption in Italy of psychoanalysis to a conservative and authoritarian Catholicism during the same era. The change of language from German to En...


A fixed point theorem concerning probabilistic contractions
satisfying an implicit relation, which generalizes a well-known result of Hadžic, is proved.


Because of the annual continuous operation, a large amount of energy is consumed to maintain a clean environment in the high-tech electronic device manufacturing clean room. In particular the energy consumption to humidify the outdoor air in winter time is enormous. Therefore, the evaluation and comparison of the annual energy consumption of steam humidification system, and indoor water spray type system has a significant meaning for reducing energy consumption in the high-tech electronic device manufacturing clean room. So I performed comparison experiment twin clean rooms using steam humidification system, indoor water spray type system and analyzed for Psychrometric chart and Energy consumption.


A phytochemical investigation of Cissus quadrangularis leaves yielded five additional known compounds including eicosyl eicosanoate, tetratriacontanol, tetratriacontanoic acid, α-amyrin and β-sitosterol. The characterization of isolated compounds was achieved by chemical and spectral studies (IR, 1H NMR and Mass Spectroscopy).


The data on the Joule-Thomson effect of the author and his colleagues are used to calculate the value of the ice point on the Kelvin thermodynamic scale from the data on the coefficients of volume and pressure expansion found in the literature. The gases involved are air, helium, argon and nitrogen. The results are, air 273.158, helium 273.168, nitrogen 273.125 and the most probable value 273.16\ifmmode\pm\else\textpm\fi{}0.02. These are compared with accepted values. The use of a helium mixture to give the ice point precisely as the reciprocal of the coefficient of volume expansion is suggested.


The article covers the analysis on slag physical property that has effect on the formability, study on the forming characteristics of the oxidizing slag for electric arc furnace application and description of main factors that influencing the formalization, such as basicity, FeO and other compositions.


Information Management (IM) is an increasingly viable career option for Library and Information Studies (LIS) students and graduates. The presenters Cathy Miller and Theresa McGinley both work in the IM industry, having graduated from the University of South Australia's LIS Bachelor of Arts in 2004. Their jobs provide them with the opportunity to apply and extend their LIS skills in an exciting environment of new technologies, including blogs, wikis, RSS and more. Although such positions may sound IT focused, LIS is a highly appropriate background for those interested in pursuing careers in IM. Based on their experiences, Cathy and Theresa will outline the actions that can be taken to tailor study, work experience and job seeking to IM pathways.


This paper examines the inextricable connection between mourning and justice in Mary Shelley's Frankenstein. Among the three concentric narratives, Victor's story contains many deaths. All the deaths except Caroline's are directly or indirectly caused by the Creature's violence and demand mourning. But Victor fails to mourn successfully because he considers himself the real cause of those deaths in that he himself created the Creature. After his hopeless attempts to gain sympathy from humans, the Creature demands Victor to create a female companion as a right. To be able to mourn, Victor should comply with the Creature's request and make things right. But his sense of duties towards his fellow-creatures leads him to break his promise to make the Creature a female companion, which incites the Creature's rage. They get caught into a vicious circle of revenge in which retributive justice is the only raison d'etre. The Creature cannot satisfy his desire for a sympathetic relation with another being and therefore destroy those who are dear to Victor. Victor gets devastated by the loss of his loved ones but cannot mourn for them successfully because he is partly responsible for those deaths. Only restorative justice can help them to break the logic of retributive justice and thereby the Mobius strip of mourning and justice. But neither of them is able to seek restorative justice and reconciliation.


The distance over which the upstream flow conditions in a tube are disturbed by a stenosis downstream, i.e. the outlet length, was investigated for Reynolds numbers in the range 210–2900. Two methods were used, the Navier–Stokes equations were solved with a computer and a physical model was constructed and maximal velocities were measured with an ultrasound Doppler system. The computer model showed that Re number does not influence the outlet length, varying the stenosis area from 25% to 90% has an effect. However, the outlet length remained small, below 70% of the diameter of the tube. The physical model confirmed for a 75% stenosis that the outlet length is small, this method set the limit at not more than 1.2 times the tube diameter.


Radial access is traditionally the first line method for percutaneous coronary interventions (PCI). However, it has its drawbacks. Recently a new distal radial approach (DRA) has been proposed. The results of using this method in patients with ACS are not defined.

 To evaluate the safety, efficacy and hospital outcomes ot treatment of patients with ACS using DRA during PCI as compared to traditional radial access (TRA).

 A single-center randomized trial included 264 people who underwent PCI in the period from November 2018 to May 2019 at our clinic. The proportion of patients with unstable angina was 60.6% (n=160), with acute myocardial infarction 39.4% (n=104). Patients were divided into 2 groups: in the 1st gr. (n=132) was used DRA, in the control 2nd gr. (n=132) - TRA. The studied groups were comparable according to the initial clinical and angiographic data. All interventions were performed by experienced endovascular cardiologists who perform more than 300 PCI per year.

 We used a program Statistica 6.0, v. 15, Pearson's criterion, Fisher's exact test, t-test.

 During PCI, 228 drug-coated stents were implanted in 104 patients. 10 patients had access conversion during PCI: from DRA to TRA in 3 patients, to femoral access - in 4 (the total number of conversions from DRA was 5.3%), from transradial to femoral in 3 people (2.3%), and therefore in the 1st group left 125 patients for observation, in the second - 129, respectively. The average puncture time was 125.1±11.9 sec. in the 1 gr. and 58.8±8.2 sec. in the 2 gr. (p≤0.00005). There was no difference in the total execution time of PCI: 30.5±7.1 min. in the 1 gr. and 29.4±4.6 min. in the 2 gr. (p≥0.1428). The duration of hemostasis was significantly higher in the TRA group: 354.2±28.1 min. against 125.4±15.3 min. in the 1 gr. (p≤0.00005). In the DRA group, there was a lower incidence of hematomas: in 1 patient (0.8%) versus 9 (7.0%) in the TRA group (p=0.019), radial artery spasm: in 7 patients (5.6%) versus 17 (13.2%) in the 2 gr. (p=0.039) and thrombosis at the access site: occlusion radial artery was observed only in 1 patient (0.8%) in the DRA group, while in the TRA group - in 8 (6.2%), p=0.036. The frequency of Major Adverse Cardiac Events (MACE) in the studied groups at the hospital stage was similar: 2.4% of cases (n=3) in the 1st gr. and 2.3% (n=3) in the 2nd group (p=1.0).

 Our one-center prospective study showed: The use of distal radial access does not extend the overall procedure time compared to transradial approach. The frequency of major complications is comparable in the two studied groups. We noted a significantly lower frequency of local complications when using DRA compared to TRA. So, distal radial approach may be an alternative to transradial access, however, large randomized trials are needed for a final conclusion.

 Type of funding source: None


Mutations in the bone morphogenetic protein type-II receptor (BMPR-II) underlie ∼70% of heritable pulmonary arterial hypertension (PAH) cases. However, the low penetrance in mutation carriers implies a 'second hit' is required for disease onset. A possible trigger is inflammation. Circulating tumour necrosis factor alpha (TNFα) is raised in PAH patients and TNFα can alter smooth muscle cell proliferation. Thus, we examined the effect of TNFα on BMP signalling. Human pulmonary arterial smooth muscle cells (PASMCs) were derived from patients with BMPR-II mutations and from disease-free controls. Quantitative polymerase chain reaction (qPCR) and western blotting revealed that 24 hours of TNFα stimulation reduced the expression of BMP2 and BMPR-II but increased BMP6 expression. TNFa reduced BMP2-mediated signalling, as expected. In contrast, BMP6 treatment in the presence of TNFα increased smad1/5 activation and upregulated ID1 expression, implying that BMP6 can signal independently of BMPR-II Furthermore, BMPR-II mutant PASMCs proliferated in response to BMP6 and TNFα. Quantitative PCR revealed increased ActR-IIa expression following TNFα stimulation and siRNA knockdown of ActR-IIa abrogated this enhanced proliferative response. In summary, TNFα increases BMP6 expression, which in the absence of functional BMPR-II, can bind to receptor complexes involving ActR-IIa to accelerate PASMC proliferation. The potential contribution of this novel mechanism to vascular remodelling in the systemic and pulmonary circulation requires further study.


puerperal fever. Of course I hardly expect that the facts and arguments telling in this relation will weigh much with those who have so far surrendered the faculty of independent reasoning as to yield submissively to the absolute dogma that puerperal fever is septiceemia and nothing else, and that there is no such thing as autogenetic puerperal fever." Even a limited experience has convinced me that absorption of the fluid which ought to be excreted after childbirth does take place in some cases under certain conditions. In three of my own, the patients-thin, delicate pluriparae, of sallow complexion, and to all appearance having very little fluid in their bodies-suddenly became fevered a few hours after getting laxative medicine. This was on the third day after delivery. The fever was of a regular puerperal type in each case, and the temperature rose in oane of them to 105° F., the feverish condition lasting six days in all. The discharge ceased suddenly, and there was only slight tenderness over the abdomen. The cases occurred in a high-lying rural locality, where no fever of any kind prevailed at the time. The true cause seemed to me to be the laxatives. If common salt can cause the absorption of fluid from the pericardial sac, surely when the womb has been recently emptied, and the walls are in a proper state to get rid of the contained fluid, purgatives may also easily produce absorption. But Dr. Leishman recommends that castor-oil will be given after forty-eight hours, and at another place he says: " It is somewhat remarkable that, sluggish as the bowels are, they respond very readily to the action of laxatives, even in the case of those who are habitually costive;" and again he says: " On several occasions we have seen an ordinary dose of half an ounce followed by such violent action as to require opiates to restrain the purging." I doubt very much whether it is proper " under the ordinary conditions of the puerperal state" to give laxative medicine at all. But I wish to point out that if the patient be thin and emaciated, and not in the best of health, it would be very much better to give injections of warm water, so that the bowels may not suck up the fluid from the surrounding parts, and cause a rise of temperature through absorption from the womb. About the violent purging above referred to, may it not be the case that the true cause was absorption of foreign material from the womb, which would rather give rise to a loss of temperature, and would be an effort of nature to get rid of the poison, as stated by Dr. Barnes.? From this year's Medical Annual, under " Puerperal Sepsis," I learn that " Dr. Braxton Hicks thinks due attention has not been paid to the effect of sudden movements in causing absorption of septic (the italics are mine) material in cases where this is only separated from the general circulation by slight and easilybroken down barriers, as clots. He specially notices sudden inspiratory efforts, as laughing, which cause considerable negative pressure in the abdomen and thorax ......... He also puts down, as examples, manipulations of the uterus, the sudden removal of the hand from the abdomen, turning over on to the side or face in bed. Ile suggests that the lower ribs and abdomen be bandaged to guard against tlhis." Does Dr. Braxton Hicks think that absorption of nothing but septic material can take place ? I had a good deal of attendance on patients two or three years ago in an outbreak of true puerperal fever, and they were all, to my mind, heterogenetic cases. The temperature did not rise immediately after getting the castor oil, and how far the laxatives acted in helping absorption no one can tell, but in another epidemic I would certainly try to hinder absorption not only by the ordinary methods of cleanliness, but also by trying to increase instead of to diminish the lochia, and that might be done by giving plenty of liquid by the mouth, and, if necessary, by the bowel also. The mechanical movements described by Dr. Braxton Hicks would seem to me to be less. powerful than the physiological effects of laxative medicine in causing absorption of either septic or aseptic material. Undoubtedly, however, they would have their own measure of influence, and ought also to be guarded against. But again I ask, Why assume that the absorption must necessarily be of " septic" materials alone ?-I am, etc., JOHN ROWAT, M.B., C.M. Tarholton.


What scholarly impact is, and how it is evaluated, vary across different countries. In the United Kingdom, for instance, scholarly impact is mainly assessed through the Research Excellence Framework (REF) in the context of providing—among other things—accountability for public investment in research, demonstrating the public benefits of research, and informing the selective allocation of research funding. In the REF system, impact needs to show a demonstrable effect on change, or evidence of benefits outside academia, and is formally assessed through case studies. In Italy, there is a comparable system for evaluating research, known as Evaluation of Research Quality, but in this latter case, the focus is on the quality of selected research outputs as indicators of research performance. Impact is here considered with reference to the so-called third mission (which includes activities aimed at the valorization of research, and activities that have positive spillovers into society at large) and is evaluated separately. Our contribution aims at critically analyzing the commonalities and differences of these two systems when it comes to evaluating research in Criminology and Criminal Justice, considering some of the benefits and potential pitfalls of research evaluation in both regions, and discussing how these disciplines are framed and delimited differently in the two countries considered.


As life expectancy increases people, we began to care for the health care aspects of attention in order to prevent the point of view is better than cure, people will gradually attention from medical practices at any time, but also want patients to be able to receive the shortest possible time With the best views and most immediate treatment, and therefore the major domestic health care facilities began putting the remote video medical care plan, it was generally found in the general definition of remote video resolution, video Specifications, such as file size and network bandwidth requirements and more limited by low coverage and therefore less practical. This paper proposes a technology for telemedicine consultation H.264/AVC system construction, the use of a new generation of streaming media technology to improve the existing poor quality, consumption of bandwidth and large file size disadvantage, the user through the System to complete diagnosis of high quality live video, remote minor surgery and high-definition video and audio guidance to clinical teaching. Therefore, by H.264/AVC video streaming media technology and the technical streaming media server (stream media server) to explore, to create a widely used high-definition video and audio streaming system architecture, system uses high-definition camera (HDV), network cameras, digital cameras, digital camera or cell phone cameras and other photographic equipment, establish a comprehensive long-distance medical consultation system, while improving audio and video streaming transmission over the Internet fluency. This system not only develop a wider variety of applications in the future can also come in a wider area of use, such as multi-network video conferencing, Internet video teaching, nursing home care, internet video chat room and High-definition digital home networking applications, can be efficiently used in synchronous and asynchronous networks of VOD (video on demand) and data base sharing (data on demand), video quality is not resolved Good, smooth video streaming and image is not recognizable and poor.


Stefano Ercolino theorizes "the novel-essay as the symbolic form of the crisis of modernity" (xv) and literary form as "a signifying structure that emerges in order to answer, on the aesthetic plane, specific symbolic needs posed by history" (xvi). To demonstrate these two theses, Ercolino discusses literature as one of many contextual forces, along with philosophy, history, music, and art, and shows that certain tendencies have led, in specific contexts, to the generation and sustainment of contingent artistic forms. The project is ambitious and the result convincing. Ch. 1 dwells on the landscape within which the novel-essay emerged. The genre "rose from the exhaustion of naturalist aesthetics" (1); it was introduced by Huysmans with Against Nature (1884), and later defined by Huysmans himself in Là-Bas (1891) and by Stringberg in Inferno (1898). If naturalism presented itself as a poetics of "battle in favor of the truth [that] had an overt ethical implication" (8) — namely the representation of "the social stillness determined by the conforming and oppressive power of monopolistic capitalism" (5) — the movement was never as revolutionary as it claimed to be, and it ultimately embraced the Zeitgeist — the Enlightenment, positivism. It was, rather, "starting from Against Nature [that] Huysmans developed an antithetical aesthetics, rooted . . . in contempt toward the Zeitgeist" (6). He introduced the essay as "the critical form par excellence" to "awaken the critical potential of literature" (9) and had characters always "escaping from the materialism of their own age with their aesthetic and metaphysical quests" (7). Against Nature constitutes the birth of the novel-essay plus the germination of the modern oppositional and fragile character — the "I" traversed by irrationalistic philosophies and psychoanalysis that inaugurates "a new attitude toward modernity: not only critical but also desperate" (9). Seven years later, Là-Bas opened with a fierce attack on naturalism, on its "materialism, mediocrity, and vulgarity" as a "vile carrier in art of bourgeois ideology" (14), a thesis replayed in Strindberg's Inferno: "the naturalistic phase was potent and fruitful, but it has served its purpose" (19). Huysmans and Strindberg converged on the need to overcome both romanticism and naturalism — on the need for synthesis, which, for Ercolino, is the need of the novelessay and the need of modernity. This aesthetics originated when "positivism's materialist reductionism and determinism both fell into crisis in the last decades of the nineteenth century" (20), leaving the ground for the rise of the "philosophies of Schopenhauer and Nietzsche" (20). As a result, synthesis became the needed response to Western European "distinctions-oriented rationality" (23). By denying distinction and seeking synthesis, the novel-essay was fighting at least 250 years of European history, launching "a direct attack against the heart of the ideological apparatus of modernity" (28) by "supporting the impossible synthesis of what philosophy and art had separated for centuries" (27). Moder-


Rhizopus Oryzae is an ubiquitous aseptate fungi belonging to order Mucorales. Rhizopus keratitis is rare and has been reported from external sources leading to corneal inoculation including trauma, surgery, contact lens use and cocaine abuse. Rhizopus Oryzae acute fulminant keratitis as a sequelae to orbital cellulitis was reported by Khalili et al. in a patient with Thalassemia major requiring therapeutic keratoplasty. To the best of our knowledge, this is the first case of a diabetic patient presenting with Rhizopus keratitis following orbital cellulitis with evidence of KOH smear and Polymerase Chain Reaction (PCR) positivity both from cornea and nasal swab 4 months after initial presentation that responded successfully to medical management. Furthermore, the presence of aseptate fungal filaments was demonstrated from maxillectomy specimen 9 months from the initial presentation indicating that Rhizopus can be indolent if inadequately treated.


A low-power wordline voltage generating system is developed for low-voltage flash memories. The limit for the stand-by current including the operation current for the band-gap reference and the stand-by wordline voltage generator is discussed. The system was implemented on a 1.8-V 32-Mb flash memory fabricated with a 0.25-/spl mu/m flash memory process and achieved with very low stand-by current of 2 /spl mu/A typically, and high operating frequency of 25 MHz in read operation at 1.8 V. A low-voltage level shifter with high-speed switching is also proposed.


Though use of theory is critical in Information Systems (IS) research, the theoretical foundations of IS research have been understudied. Using Social Network Analysis, we analyze theory usage in IS research published in MIS Quarterly and Information Systems Research from 1998 to 2006. We find Technology Acceptance Model, ResourceBased View and Game Theory to be the three most frequently used theories. While strong dominance is found in research focusing on Information Technology (IT) for individuals, organizations and markets, no theoretical dominance is found in IT for groups and IS development. Psychology, Economics and Sociology are disciplines IS researchers most frequently leverage for theories. Psychology contributes several theories representing a large fraction of the long tail of theories. Our analysis suggests that IS consists of a few distinctive clusters of research instead of a single core. Our results provide insights on theoretical foundations of IS and suggest research opportunities for scholars.


Adequate and relevant library resources and services, at the level of postgraduate degrees offered by Nigeria universities should be that which support the intellectual culture of conduction an independent study. Hence, the degree of utilization of library resources for effective research output among postgraduate students of Babcock University becomes critical to understudy. This study made use of the survey research design method. A total enumeration sampling technique was used for the selected sample. A total of 51 respondents made the total sum of the students. The major objective of the study was to investigate the utilization of library resources for effective research output by post graduate ministerial students of Adventist University of Africa (AUA) in Babcock University. Findings revealed that the most frequently used library materials is the online database, dictionaries, books and encyclopedia which are used daily, while the least used material was CD-ROM database. Furthermore, respondents in this study affirmed that the available library resources have a very low impact on their respective research work. This influenced majority of the respondent's level of satisfaction with the use of library information resources to be perceived low. A test of relationship among AUA posts graduate students accessibility and use of library resources in Babcock University was positive at P>0.01 significant level. In conclusion, bases on the result, Libraries in Nigerian universities should regularly evaluates the quality, adequacy, and use of their library's information resources and services in other to meet up with the quality of library services.


Purpose: This study was designed to evaluate the effect of vitrectomy on the recovery of impaired visual acuity from complication of branch retinal vein occlusion (BRVO). Methods: The medical records were obtained from all patients who underwent vitreoretinal surgery for complication of BRVO and were followed up at least for 6 months postoperatively. Results: The Surgical indications included vitreous hemorrhage (29 patients), epiretinal membrane (7), and retinal detachment (4). Mean follow-up was 13 months. Preoperatively, best corrected visual acuity was greater than or equal to 0.1 in 14 eyes (35.0%). Six months postoperatively, best corrected visual acuity was greater than or equal to 0.1 in 36 eyes (90.0%). Clinical features associated with better visual outcome included better preoperative visual acuity (P


Simazine and atrazine were more efficient but not selective on ragi. Nitrofen was the most selective pre-emergence herbicide for the crop at 0.5kg a. i./ha and it also recorded the maximum profit. 2, 4-D was useful as a post-emergence herbicide. Different moisture regimes had no influence on the various yield attributes and yield in the first year. All the moisture levels influenced the grain yields independently, since the crop was raised in the rainless summer season.


First few years of life is a crucial time for growth and change, both physically and mentally. Thus understanding the baby at this time for laying a good foundation is a must. But recognizing an infant's emotions and needs is complex. The only way of communication is their cries, murmurs or facial expressions. So to put a light on it, this paper presents the various ways in which we can recognize an infant's emotion through video clips. What is modality, types of modality and its importance will be seen. Different unimodal and multimodal systems will be studied. Image processing, speech processing and classification algorithms required for the systems will also be covered.


Although branded as 'obstructionists' and major agents of 'disease and filth' by city authorities, food vendors remain the pivotal node in the local food system in most informal settlements; therefore, their interaction with the environment and infrastructure services, and challenges they face to keep the food safe to eat, requires further grounded exploration. Food vendors from informal settlements in Nairobi, Kenya, who are acting as mappers and change agents, are building multi-layered views of places through the deliberative process of knowledge coproduction by participatory sensing, which lead to opportunities and challenges to improve those places.


10502 Background: Doxorubicin (D) is the only approved first line therapy for most advanced soft tissue sarcomas (STS). Aldoxorubicin (A) consists of doxorubicin attached to an acid-sensitive linker that binds covalently to serum albumin. We compared the efficacy and safety of A to D as first line treatment for patients with advanced STS. Methods: 31 site international trial; 123 patients ages 18-78 years with histologically confirmed metastatic, locally advanced or unresectable STS randomized 2:1 to receive either 350 mg/m2 A (260 mg/m2 D equivalents) or 75 mg/m2D, every 3 weeks for a maximum of 6 cycles. Tumor response by CT was monitored every 6 weeks until completion of treatment, 2 months post treatment, then every 3 months to progression or withdrawal from study. Primary endpoint: progression-free survival (PFS). Secondary endpoints: overall response rate (ORR), PFS at 6 months and overall survival (OS). Both a blinded, independent review and an investigator site review were performed for each scan....


Concrete is the second most consumed material in the world. However, the concrete industry has enormous environmental footprint, resulting in high energy consumption and CO2 emissions. The challenge for the structural designers is to reach optimal dimensions for structural elements without compromising its saftey. In this paper the goal is to evaluate the different philosophy between the Egyptian Code of Practice and the Eurocodes. As a case study a reinforced concrete structure is compared in view of three aspects: sustainability, economy and reliability. First a finite element model is developed to design the structure according to both codes. Then a detailed bill of quantities for the structure is conducted to calculate the environmental footprint and the cost of the building. In addtion, an advanced probabilistic model is established to provides a framework for the reliability analysis of the structure. Finally the results of the sustainability and economy comparison are presented.


To the Editor: In 1980, I compiled a bibliographic tabulation (1) of topics covered by 4965 scientific articles published in Clinical Chemistry 1-25 (1955-1979). As a complement to this report on the 25year distribution of the subject matter in Clinical Chemistry, it would be interesting to know the types of institutions with which current contributors to Clinical Chemistry are associated. For example, the findings can be considered along with other publications about this journal, such as the recent eight-year index Clinical Chemistry: Cumulative Index, with Citations. Thus, the purpose of this communication is to make readily available for the first time a summary of quantitative information based on the nature of the main affiliations cited in the addresses of the authors (the senior author only, in the case of multiple-author papers) of 544 scientific articles in volume 26 (1980) and 587 in volume 27 (1981). This total of 1131 articles examined excludes abstracts, non-scientific items, and book reviews. Usually the co-author(s) of a given paper has the same affiliation as the senior (first) author. Even when the actual addresses may differ, the category of the affiliate organizations of all authors is ordinarily the same. Of the articles tallied, 60% originated in the United States. A related incidental statistic is that only 29% of the 841 individuals who are single (or senior) author contributors are members of the American Association for Clinical Chemistry (AACC). (I did not tally the AACC members among the co-authors.) In Table 11 have ranked the four categories that denote the main affiliate organizations of the senior author contributors. The corresponding percentages of authors within each of the four professional categories differ so little between the two years that, for the sake of brevity, I combined the separate yearly summary data into Table 1, giving averages of the total two years' percentages, rounded to the nearest whole number. There appear to be few surprises, and the conclusions are straightforward. The overall total data are shown to reflect a 77% predominance of papers distributed about equally among hospital (40%) arid academic-based investigators (37%). Many of these contributors list combined hospital clinical laboratory/university medical school type of addresses and do not identify which of the two is their "main" professional affiliation. The remaining 23% of the articles is divided, also nearly equally, between researchers associated either with industrial organizations (12%) or with research institutions (11%). The percentages of American and foreign contributors with hospital affiliations are similar (18% and 22%), as are the percentages with research institute affiliations (7% and 5%). This pattern contrasts with the substantially different percentage of American versus


Introduction In a more technological and literate society statistics plays a relevant role (Batanero & Godino, 2001), namely to allow people to become critical and active citizens. Statistics is part of our daily life. Most media refer to statistical knowledge showing graphs, tables or means in order to sound as being scientifically supported and to be able to manipulate people's opinions about what is going on in the world. Choosing the information one reads, analyzing it, processing data and deciding different ways of presenting them are some of the competencies that we need to mobilize and develop (Gal & Garfield, 1997). Otherwise one experiences exclusion at a more or less visible level, but still affecting one's power to participate in social practices, like voting, deciding what to buy, how to pay taxes, or even about recycling – or not – one's waste. In this sense, "Statistics is seen like a tool allowing for understanding and interpreting the world around us, thus contributing to the education of autonomous, critical, and participant individuals (...)" (Brocardo & Mendes, 2001). But, as Lajoie, Jacobs, and Lavigne (1993) stress, not only adults need to be literate and critical about statistical knowledge. According to these authors, children (and teenagers, we would add) also need to become more active and critical citizens. Thus, they need to have access to statistical knowledge that develops complex functions (Vygotsky, 1932/1978, 1934/1962) and not only to meaningless procedures they mechanically learn to use (Mokros & Russel, 1995), even if some authors state that pupils usually begin by using procedural competencies before achieving relational ones, mainly due to their previous instruction in statistics (Cobb & McClain, 2004). School practices play an essential role in the access pupils will have, or not, to these forms of literacy so deeply needed in a complex, changing and multicultural society. In the 21st century most countries and schools are becoming increasingly multicultural. Thus, diversity is a reality teachers must accept and respect (D'Ambrosio, 2002; Favilli, Oliveras, & Cesar, 2003). In most classes there are pupils from different cultures and home backgrounds, with diverse mathematical traditions, ways of reasoning, and ways of solving mathematical tasks. Some cultures are quite far from the mainstream one, and also from the school culture (Cesar & Favilli, 2005). Thus, being able to use diversity as richness instead of avoiding it is one of the main challenges teachers face nowadays (Cesar, 2003).


The present invention discloses a waste water treatment plant sludge drying method belongs to the field of environmental protection. The present invention uses pre-dewatered sludge stirring and mixing modification pretreatment material, sludge achieve sterilization, deodorization; pH modifier after the hydration reaction materials and reaction, water causes the inner body microbial sludge particles bleeding, weakly bound and free water sludge particles are separated, thus improving the dewatering properties of the sludge particles; extruding machine using sludge is extruded into strips, thermal drying sludge increased surface area. The dehydrated sludge after pretreatment method having a low heat consumption, fast drying speed, good drying sludge modification effect, no secondary pollution.


The Galter Health Sciences Library's Special Collections is often used to promote the library in the life of its medical school, and this year it fulfills a crucial, supporting role in the sesquicentennial celebrations. Because much of the school's history is located in the Special Collections' resources, it is the library's responsibility to share this history and use it as a means of promoting the school's future excellence in education, research and patient care based on a record of past success.


The article considers the history of the first citywide youth organizations in the provinces of the Middle Volga region in the end of XIX th and the beginning of the XX th centuries. The causes of the rise of student organizations across the city, their participants, the main spheres of activity are analyzed in this article. The author concludes that in this region, the emergence of the first student unions dates back to the end of the XIX th century (1899), a few years earlier than it happened countrywide. The author also points out that the presence of a leading center in the youth movement is the evidence for its political character.


In this paper, we apply a non-negative matrix factorization (NMF) technique to propose a method of estimating noise occurring in non-stationary environments. In the proposed method, the basis matrix of the target noise is first obtained via NMF training. The noise basis is then applied to estimate an activation matrix of the target noise from the noisy signal. The proposed method is finally applied to reduce the auto-focus (AF) noise in a digital camera. It is shown from the experiment that the proposed method provides a better estimate of the AF noise than a conventional method based on signal-presence probability.


Engineering process preparation requires proper preparation of cutting tools. It influences not only the performance of the tools but also the quality of workpiece surface machining. One of the promising environmentally friendly trends of mechanical treatment is grinding without using lubricating cooling liquid. This method can considerably influence the quality of cutting tools grinding. Smoothing skiving turning is an effective treatment method providing high efficiency and workpiece quality. Proper preparation of cutting edges is especially important in this process. For that purpose we have carried out a research in grinding changeable carbide inserts for skiving turning by means of grinding wheels with different grain size. The influence of different combinations of wheels on roughness of the inserts front and rear surfaces and quality of cutting edge was studied with the help of laser confocal microscopy.


Magnetic Resonance Imaging (MRI) is an invaluable diagnostic tool for imaging the human body, diagnosing and characterizing diseases, and developing new treatments. In this work, we investigate capabilities of the Quantitative Ultra-short Time-to-echo Contrast-Enhanced (QUTE-CE) MRI to quantify nanoparticle accumulation in tumor, which is of great clinical interest for stratifying cancer patients who may benefit from therapeutic nanoparticles. Using FDA-approved superparamagnetic iron oxide nanoparticle (SPION) ferumoxytol in QUTE-CE MRI, we produce quantitative measurement of contrast, delineates clear, positive-contrast brain/tumor vasculature image in mice and rats. In our study, QUTE-CE MRI improved contrast and contrast efficiency compared to conventional high-resolution T1and T2-weighted imaging. Whole tumor analysis demonstrates enhanced delineation of nanoparticle accumulation. This technique allows for identification and characterization of local hotspots in ferumoxytol uptake. QUTE-CE MRI is sufficiently sensitive to detect radiation-induced changes in both ferumoxytol penetrance and focal accumulation. QUTE-CE MRI is ideally suited for noninvasive visualization and quantification of tumor nanoparticle uptake, and accordingly, it can potentially be used for identifying cancer patients who can respond to treatment with therapeutic nanoparticles. Traumatic brain injury (TBI) is one of the most prevalent risks of death and disability in young people; about 1.6 million cases are reported per year in the US. Some of the most devastating injuries from brain trauma are the rupturing of arteries between the dura and the skull in an epidural hematoma (blood brain barrier disruption), as well as tears in emissary veins, resulting in hemorrhagic contusions seen in subdural hematomas. This accumulation of blood can squeeze and increase pressure on the brain. Here, we introduce


This issue of Acta Physiologica presents the latest work of Dr. Zhang and his team concerning the mechanism of activation of small-conductance Ca2+ -activated K+ (SK) channels, and more precisely the SK2 subtype.1 Indeed, these still poorly understood channels play important roles in the physiology and the pathology of several types of cells. SK channels are encoded by four different genes, namely KCNN1 for SK1 (KCa2.1), KCNN2 for SK2 (KCa2.2), KCNN3 for SK3 (KCa2.3) and KCNN4 for SK4 (IK or KCa3.1) channels.


The present invention discloses an automotive exhaust system attachment brackets mold assembly comprising an upper die and a lower die assembly, the upper mold assembly includes an upper mold base, and the plate punch plate; said lower die assembly includes a lower die holder, the die plate and the stripper plate is fixed; component tape between the upper mold and the lower mold assembly located in the punch fixing plate is fixed to a U-shaped punch punch for punching, two punch for bending of 30 °, for three bent 45 °, for a bend of 90 ° and a punch for cutting off the edges punch material, and is fixed to the punch of the same number in the fixed die plate, with the punch of complementary shape to a U-shaped die cavity, a recess for the punching mode, two 30 ° for bending the die, three for bending 45 °, a 90 ° bend for the die and a die for cutting off the scrap. Material of the present invention, high efficiency, high production efficiency, quality and stability.


The article is dedicated to determination of the main personal, business and professional qualities of the leader of the state institution. Main personal and business and professional qualities of the leader, which render the assistance to efficient management activity, are revealed. It is proved that motivation of professionally and intellectually important, mentally and socially necessary qualities of the leader there is one of the most actual problems to psychologies of management. The representatives of new management elite are not as much people younger, as new professionals, capable be adapted to change, who understands that success to their activity, except the other, is concluded in work on itself. The modern manager is a person, who tries to create «its person», who understands that not will have a success if simply copies the style, thoughtless imitate.


Photodissociation of trinuclear carbonyl cluster compounds of Fe, Ru and Os was studied by recording the mass spectra produced from laser ablation of the cluster compounds. Under the experimental conditions, dissociation of the cluster compounds is very extensive, but the dissociation pathway of the osmium cluster is different from those of the iron and ruthenium clusters. The iron and ruthenium clusters not only lost their carbonyl ligands, but their cluster cores were also fragmented. As the osmium cluster dissociated, it ejected three pairs of oxygen atoms, in sequence, before losing the carbonyl ligands, but the trinuclear osmium core did not fragment. This specific dissociation scheme of the osmium cluster reveals its special structural stability. Not only does it have stronger metal-metal bonds, but also a relatively stable coordination bond formed between osmium and carbonyl ligands. In addition, different distributions of positive and negative fragment ions were observed in the experiment. This difference is interpreted as the result of different stabilities of their electronic structures.


During the 125th European Study Group with Industry held in Limassol, Cyprus, 5–9 December 2016, one of the participating companies, Engino.net Ltd, posed a very interesting challenge to the members of the study group. Engino.net Ltd is a Cypriot company, founded in 2004, that produces a series of toy sets – the Engino® toy sets – consisting of a number of building blocks, which can be assembled by pupils to compose toy models. Depending on the contents of a particular toy set, the company has developed a number of models that can be built utilizing the blocks present in the set; however, the production of a step-by-step assembly manual for each model could only be done manually. The goal of the challenge posed by the company was to implement a procedure to automatically generate the assembly instructions for a given toy. In the present paper, we propose a graph-theoretic approach to model the problem and provide a series of results to solve it by employing modified versions of well-established algorithms in graph theory. An algorithmic procedure to obtain a hierarchical, physically feasible decomposition of a given toy model, from which a series of step-by-step assembly instructions can be recovered, is proposed.


Product rich in 1,3-distearoyl-2-oleoylglycerol(SOS) was produced via acidolysis reactions of high oleic acid vegetable oil and stearic acid by 1,3-regiospecific lipase in a free solvent system.The impact factors of enzyme load,ratio of stearic acid to high oleic acid vegetable oil,reaction time,reaction temperature on SOS,1,2-distearoyl-3-oleoylglycerol(SSO) and glycerol tristearate(SSS) content were investigated.High content of SOS was expected,as well as the low contents of SSO and SSS.The results showed that the optimum cinditions were enzyme load 10% of substrate,ratio of stearic acid to high oleic acid vegetable oil 4∶1,reaction time 3 h,and reaction temperature 65℃.Under these conditions,the content of SOS,SSO and SSS in reaction products was 39.58%,1.18% and 0.28%,respectively.