. This paper deals with the Port Rail Shunting Scheduling Problem (PRSSP), a problema rising in the rail-sea yard where the modal switch between maritime and rail transportation is performed. In particular, the focus is on the trains' transfer operations within the port area, between the maritime terminals, and the railway network. These operations are performed in an area called shunting zone characterized by some infrastructures (i.e., tracks, shunting parks) and some other limited resources. The PRSSP consists in defining the schedule of all activities necessary for transferring export and import trains from the railway network station to the terminals and vice versa, respecting the time limits imposed by the railway network schedule and by the ships one, and the limits due to the finite resources available in the shunting zone. An operations-time-space network representing the rail station and the terminals (either the origin or the destination of the trains) and the operations that might be performed on the trains in each zone of the port is used for modeling the problem. A flow model based on this operations-time-space network is used for solving PRSSP. Extensive experimental tests are reported and show the validation of the model as a useful tool for the shunting managers to either evaluate the maximum number of trains that can be served or define the bottlenecks of the port system.


This study examined national data from two women's cohorts to determine the likelihood that Black grandmothers who resided with grandchildren were more likely than other grandmothers were to have daughters who resided with grandchildren. Of 1098 co-resident grandmothers, 390 (36%) were in the younger of the two cohorts, 603 (55%) were in the older, and 105 (9%) tier in both, comprising the sub-sample of grandmother-grandchild mother-daughter pairs, A significantly higher proportion of mothers in the grandmother-grandchild mother-daughter pairs were Black (83%) compared to 37% of the mothers among the non-paired ever co-resident grandmothers. The study also found, by proxy, that the co-resident grandmother-grandchild mother-daughter pairs had lower socioeconomic standing than non-paired ever co-resident grandmothers


The E-Health transformation of the health sector in Dubai kept as a top priority agenda since two-decades back. As part of comprehensive e-government transformation initiative, Dubai has to move to absolute smart -government within few years ahead from now, taskforces, plans, resources, and activities are already assigned and going on successfully at the current time, tremendous Developments were put in a place since ever. In Digital Healthcare envisions, the enormous investment in technical resources and workforce has been pumped to address the infrastructure requirements, at both the technical and work force level of the capacity building process. A sustainable digital health ecosystem extensively empowered local e Health workforce. Significant financial resources have been pumped in the pipeline so far to reach this objective. Extensive Stakeholders–( government, education, industry, healthcare organizations, and others have been put on board, a framework for standards and professional development in eHealth were created. Loyal, long-term discussions, sharing the experience with worldwide best practice, exchanging multiple ideas, then ideas, and then moving forward to invest in the eHealth workforce and professional development.1–5 Objectives


One of the most important reliability approval tests carried out in order to ensure reliability in the consumer electronics is the short-term voltage interruption test. This test simulates the short-term interruptions in mains voltage. Shortterm interruptions occur in mains voltage faults by a sudden large change of load and voltage variations. In this study; for consumer electronics products, the importance of fail conditions that would occur in the short-term interruptions in the mains voltage is discussed. As an experimental study, a led driver circuit is tested.


Abstract 4505 Invasive fungal infections (IFI) such as candidiasis and mold infections cause significant morbidity and mortality among immunocompromised patients in recent years. Micafungin, a new echinocandin, inhibits fungal cell wall beta-glucan synthesis, with potent activity against most species of Candida and Aspergillus. The aim of this observational study was to investigate the efficacy and safety of Micafungin in prophylaxis of invasive fungal infections (IFI) in 20 high risk adult patients with various haematological diseases receiving haplo-identical allogeneic stem cell transplantation (Allo-SCT). Treatment success was defined as no proven, probable, or suspected IFI through therapy and the absence of proven or probable IFI through the end of 12 weeks after therapy. (EORTC criteria). These patients were monitored after Allo-SCT for galactomannan antigenemia at least once per week, and a computed tomography (CT) scan was performed in the case of persistent fever for at least 5 days after broad-spectrum empirical antibacterial therapy. Routine controls (e.g. detection of galactomannan antigenemia and CT scan) were performed systematically after 1 and 2 months and on day 100 after Allo-SCT. Only 2 patients had a history of possible aspergillosis before transplant treated by voriconazole. The patients received a median of 4 lines (2–7) of treatments before Allo-SCT. Ten patients (50%) received at least one auto-SCT; and 5 patients (25%) received a previous Allo-SCT. 18 patients (90%) received a reduced intensity conditioning regimen (RIC), with Fludarabine, Cyclophosphamide and Total body irradiation (TBI) 2 Gy based (75%), or Fludarabine, Busulfan, and Cyclophosphamide based (10%) or other (5%). while two patients (10%) received a myeloablative conditioning regimen with thiotepa. The patients and transplant details are shown in the table 1. Patients received a median of 26 infusions (range, 1–8) of Micafungin (50 mg/day i.v. as a 1h infusion). The treatment was initiated at the beginning of the transplant conditioning regimen until the hospital discharge. None of our patients discontinued the treatment for drug-related adverse events. Micafungin was not associated with any hepatotoxicity. Only one patient (5%) discontinued the treatment because an early disease progression. At last follow-up, there are 17 patients (85%) who are alive, with a median follow-up of 6 months (3–17). Three patients (15%) dead because disease progression. In all patients no candidas and/or Aspergillus species was documented after 3 and 6 months from transplant. None of our patients presented a positive galactomannan antigenemia >0.5. Seven patients (35%) presented a CMV reactivation. Only one patient presented an acute GvHD grade II. Micafungin has a good safety and tolerability profile, with an efficacy in preventing IFI in this high risk population. Our data provide support for an efficacy study in a prophylaxis setting, but prospective and comparative clinical trials using Micafungin are urgently needed to define the role of this drug in prophylaxis after haplo-identical Allo-SCT. Disclosures: No relevant conflicts of interest to declare.


Lineaments seen in ERTS-1 imagery of the Atlantic Coastal Plain represent previously unrecognized structures that have been "inherited" from the underlying basement rocks through thousands of feet of unconsolidated sediments. The major lineaments have preferred orientations of about N05W and N50E, indicating, perhaps, north-south compression. The origin of most of these lineaments is not known, but it is certain that many of them are the surface traces of faults, some of which may have moved in comparatively recent times, such as that which caused the Charleston, South Carolina, earthquake of 1886. Associated with the lineaments are numerous circular depressions, some as much as 15 miles in diameter. To test the hypothesis that movement along these faults has taken place in comparatively recent times, a lineament in the eastern part of Maryland was examined. This lineament extends northward,parallel to and west of the Maryland-Delaware line, to eastern Pennsylvania, a distance of about 100 miles. Although the soil on both sides of the lineament is predominantly sandy, that on the eastern side is poorly drained, which has resulted in the accumulation of as much as 18 percent organic material in the soil. East of the lineament a bed of clay that occurs just under the B horizon of the soil contains fresh water spores that have been dated at about 12,000 years. This suggests that the area east of the lineament was down-thrown about 12,000 years ago, causing ponding of the drainage and creating an environment in which organic material could accumulate. The circular depressions are perhaps formed by piping along the fault traces. If this lineament is indeed a fault and the date for the last movement is correct, the seismic significance should not be lost in urban planning of the Middle Atlantic Coastal Plain area.


Background Respiratory distress syndrome and transient tachypnea of newborn are common causes for admission to neonatal ICU. Measurement of diffusion coefficient of carbon dioxide (DCO2) and partial pressure of carbon dioxide in arterial blood (PaCO2) are useful to detect changes in alveolar ventilation, pulmonary perfusion, and CO2 production and help adjust ventilation settings. Aim Our study evaluated DCO2 in relation to PaCO2 as a maker for weaning from high-frequency oscillatory ventilation (HFOV). Patients and methods A total of 40 neonates were included in the study and were divided into two equal groups based on their gestational age (preterm vs. full term), and we measured DCO2 and PaCO2 in both groups at the time of shifting to HFOV and every 4 h till weaning from HFOV. Results The mean value of DCO2 was significantly higher in the full-term group, and there was no statistically significant difference between both studied groups regarding the mean value of PaCO2, except on the third day and at the time of weaning to conventional mechanical ventilation, where it was significantly higher in the preterm group. There was a significant negative correlation between mean value of DCO2 and mean value of PaCO2 on the first, second, and third day of HFOV and at the time of weaning to conventional mechanical ventilation. Conclusion DCO2 can be used roughly as a reflection for CO2 status but cannot be used alone as an indicator for weaning from HFOV but could be used in combination with other markers.


The study investigated the proximate composition and functional properties of instant plantain breadfruit composite flour. The flour was prepared from precooked unripe matured plantain and breadfruit. Instant flour made from plantain (P) and breadfruit (B) were blended together in ratios: 100 P : 0 B (A); 75 P : 25 B (B); 50 P :50 B (C); 25 P : 75 B (D) and 0 P :100 B (E)). The proximate composition, energy value and functional properties of the flours were analysed with standard procedures. The proximate composition are moisture (6.93 % to 8.50 %); protein (3.59 % to 3.30 %); fat (1.64 % to 2.53 %); fiber (3.95 % to 8.06 %); ash (2.36 % to 2.99 %); carbohydrate (76.15 % to 80.13 %) and energy (332.56 Kcal/100g to 357.67 Kcal/100g) The functional properties are bulk density (BD) (0.69g/g to 0.86 g/g ); water absorption capacity (WAC) (250.01 % to 335.01%); oil absorption capacity (OAC) (0.99g/g to 1.39 g/g ); solubility index (SI)(8.99 % to 14.78% ) and swelling power (SP) (4.62 g/g to 7.38 g/g). Blending of plantain and breadfruit flours together resulted in flours with improved nutrient and functional properties. .


Objective To evaluate the clinical effect of amiodarone on paroxysmal atrial fibrillation. Methods 125 patients with paroxysmal atrial fibrillation were randomly divided into amiodarone hydrochloride-treated group(78 cases) and propafenone hydrochloride control group(47 cases) .The experimental group was treated with amiodarone hydrochloride 150 mg for 10 min within 30 min,if not recovery,150 mg for another 10 min;if not recovery,1 mg/min infusion for 6 h,then instead of 0.5 mg/min infusion for 48 h,and oral 0.2 mg /time,three times a day.The control group was treated with propafenone hydrochloride 150 mg for 10 min,if not recovery after 20 min,35 mg or 70 mg bolus for 10 min,and then oral propafenone hydrochloride tablets was used,200 mg /time,3 times daily.The effective rate in cardioversion of atrial fibrillation and adverse reactions were observed within a week.Results The effective rate in amiodarone hydrochloride-treated group was 92.5%(62/67) ,and in the control group was 79.3%(46/58) .The difference was statistically significant between the two groups(P 0.05) .Conclusion Amiodarone hydrochloride is effective in cardioversion of paroxysmal atrial fibrillation,and the efficacy was superior to propafenonehydrochloride.


Carbosilane dendrimers can be used as soluble supports for organic synthesis, since their structure allows separation of excess reagents from the supported products, eventually yielding products of high purity and in high yield, as in solid-phase organic synthesis (SPOS). In previous studies often loss of dendritic material during filtration was observed, due to the rather flexible structure of the conventional dendrimers. In order to improve the diafiltration retention of the carbosilane dendrimers, the synthesis of carbosilane dendrimers based on more rigid-core molecules was investigated. Both 1,3,5-tris(4-bromophenyl)benzene 1 and tetrakis(4-bromophenyl)silane 2 were selected on the basis of their rigid structure and suitable functional groups for further functionalization using organolithium chemistry. An optimized halogen lithium exchange (HLE) protocol was developed for the synthesis of 2 via 1-bromo-4-lithiobenzene. This protocol involves reaction of an aryl bromide with n-BuLi at room temperature...


East-central European cities arrived at a new phase of their development after the collapse of the former political system. This paper seeks to explore the impact of recent political and economic changes in Budapest, focusing mainly upon problems linked to the privatisation of the built environment and economic life. The rapid transformation of the economy not only reorganises the function and the role of Budapest within its wider region, but also reshapes the internal structure of the city. Due to the large-scale privatisation of housing and the very dynamic growth of the private economy, there is a functional conversion of the central part of the city. Small-scale businesses are mushrooming, and many of the newly established firms rent or buy recently privatised flats for office and business purposes. The dynamic growth of the so-called service sector and business-oriented employment also tends to generate a rapid population change and the improvement of the socio-economic status of certain neighbourhoods.


Space-Time Adaptive Processing (STAP) based on matched filter processing in the presence of additive clutter (modeled as colored noise) requires knowledge of the clutter covariance matrix. In practice, this is estimated via the sample covariance matrix using samples from the neighboring range bins around the reference bin. By applying compressive sensing, the number of training samples needed to estimate the covariance matrix can be significantly reduced, provided that the basis mismatch problem, inherent to compressive sensing can be mitigated. This paper presents an adaptive approach to choosing the best sparsifying basis, using dictionary learning to estimate the radar clutter subspace. Numerical results show that the proposed algorithm achieves the desired reduction in training samples, and is more accurate than previous reduced-rank algorithm baseline.


Through a focus on Anglo-German collaborations, this chapter argues that enthusiastic cooperation with scientists from other countries remained not simply a vital feature of the activities of the British Association for the Advancement of Science (BAAS) from its beginnings in the early 1830s through to the years of the First World War, but also a fundamental and irremovable aspect of its self-perception, both at an institutional and individual level. The chapter focuses on the years between 1870 and 1914, as this is the period in which many historians have identified an important shift in the activities and ideology of the BAAS. The argument put forward in the chapter draws upon a recent reinterpretation of the nineteenth century, not simply as the age of the nation state, but also as an era of growing globalization, in which cross-border contacts played an increasingly important role. Keywords: Anglo-German collaboration; BAAS; First World war; globalization


Knowing that humans overexaggerated extracting nonrenewable natural sources which caused nonequal quality of life lead to the awareness that energy and mass flows generated by mankind should be decreased drastically. Onlythan the sustainable development on the planet could be achieved. Slovenia also expresses commitment to the sustainable development. The grade approaching to the final goal can be measured only by an appropriate method. In the last years the environmental footprints become wide used. In the paper the method is described and first time used for calculation of environmental footprints of Slovenian inhabitance. It was found out that current development is non sustainable because environmental footprints of Slovenian's are greater than local and global bio-productive space. The influence of the current energy use on the environmental footprints is analyzed and prediction of the future environmental footprints caused by the use of energy predicted in most important national strategic documents and EU Directives up to year 2020 are presented.


Scenes in movies are the reflections of how human being would act and react in facing daily life real drama. This study sought the types of human psychology when they deal with life realms that are portrayed in a movie called The Danish Girl based on Freud's Tripartite Psychological Model . The method utilized in this study was mainly descriptive qualitative design. The data source was a biographical movie entitled The Danish Girl directed by Tom Hooper, which was released in 2015. The subject was the character named Einar Wegener, who transgendered himself into a woman named Lili Elbe. The objects were all scenes that are in accordance with the Freud's Tripartite Psychological Model . The data were collected by merely observing the movie for 120 minutes and marking the relevant scenes. After the data were obtained, based on the Tripartite Psychological Model , the results suggest that there are 48 scenes of Einar altogether; 36 scenes representing the identity, 7 scenes representing the ego, and 5 scenes representing the superego. In conclusion, although he was biologically male, Einar was indeed born transgender in this movie which can be interpreted through his motives of life.


Organisations are increasingly turning to Content Management Systems (CMS) to handle the delivery of information to stakeholders. For companies hoping to supply to the mobile demand there are two options: either create duplicate information for mobile devices or leverage their existing CMS data. As the creation of duplicate information is often excessively time consuming and costly, leveraging existing content and repurposing it to a mobile friendly format is the optimal route. This paper explores the case of Oakland County's eGovernment in this endeavor, and proposes a three-stage approach involving a Process Transformation Framework (PTF), a Mobile Content Platform (MCP), and an Asset Leverage Strategy (ALS), that affords flexibility, scalability and reuse of existing digital content by organisations for the mobile channel. In addition, the requisite market research to identify the web content and services of greatest value proposition to a government's constituents (residents) is presented.


The principles and molecular mechanisms underlying biological pattern formation are dif fi cult to elucidate in most cases due to the overwhelming physiologic complexity associated with the natural context. The understanding of a particular mechanism, not to speak of underlying universal principles, is dif fi cult due to the diversity and uncertainty of the biological systems. Although current genetic and biochemical approaches have greatly advanced our understanding of pattern formation, the progress mainly relies on experimental phenotypes obtained from time-consuming studies of gain or loss of function mutants. It is prevailingly considered that synthetic biology will come to the application age, but more importantly synthetic biology can be used to understand the life. Using periodic stripe pattern formation as a paradigm, we discuss how to apply synthetic biology in understanding biological pattern formation and hereafter foster the applications like tissue engineering.


o-Aminoaryl ketones underwent smooth condensation with a variety of α-methylene ketones in the presence of NaHSO4.silica gel as a solid acid catalyst to afford 1,2,3-trisubstituted quinolines in excellent yields. The reusability of the catalyst has made the protocol simple, cost–effective and environmentally benign.


A group of long-acting, peptide-based, and selective GLP-1R/CCK-2R dual agonists were identified by rational design. Guided by sequence analysis, structural elements of the CCK-2R agonist moiety were engineered into the GLP-1R agonist Xenopus GLP-1, resulting in hybrid peptides with potent GLP-1R/CCK-2R dual activity. Further modifications with fatty acids resulted in novel metabolically stable peptides, among which 3d and 3h showed potent GLP-1R and CCK-2R activation potencies and comparable stability to semaglutide. In food intake tests, 3d and 3h also showed a potent reduction in food intake, superior to that of semaglutide. Moreover, the acute hypoglycemic and insulinotropic activities of 3d and 3h were better than that of semaglutide and ZP3022. Importantly, the limited pica response following 3d and 3h administration in SD rats preliminarily indicated that the food intake reduction effects of 3d and 3h are independent of nausea/vomiting. In a 35-day study in db/db mice, every two days administration of 3d and 3h increased islet areas and numbers, insulin contents, β-cell area, β-cell proliferation, as well as improved glucose tolerance, and decreased HbA1c, to a greater extent than ZP3022 and semaglutide. In a 21-day study in DIO mice, once-weekly administration of 3d and 3h significantly induced body weight loss, improved glucose tolerance, and normalized lipid metabolism, to a greater extent than semaglutide. The current study showed the antidiabetic and antiobesity potentials of GLP-1R/CCK-2R dual agonists that warrant further investigation.


This book is about art therapies in schools, 'encompassing music, art, drama and dance movement psychotherapy and brings together international contributions dealing with re earch and practice in the field ' (p9). Within the introduction Karkou explains the reason for publishing the book and outlines amongst other things, current research in arts therapies practice in education (p.14). The book is divided into two parts: Part one: Mainstream chools and Part two: Special chool . Each chapter follows a imilar structure starting with an introduction, followed by a robust literature review, and then the re earch i di cu sed, and evaluated. Many chapter contain first class documentation of evidence-based resear h within education. Each therapi t present well-thought out, conci e investiga tion. rt is important to note that in most case the interventions are hortterm but nonetheless arc succe ful in rai ing awarene s of the different therapeutic disciplines within this specific context.


The CAMI-1 study dealt with the depletion of CRP by apheresis in patients with acute myocardial infarction (AMI). CRP, the prototype human acute phase protein, has been known as a marker of poor prognosis in AMI and independently predicts 30-day mortality.

 66 STEMI patients were enrolled in the study following complete coronary revascularization (2–12 h after the onset of symptoms). 32 patients received CRP apheresis, whereas 34 patients treated by standard protocols served as controls. CRP apheresis started 24±12 h and 48±12 h after onset of symptoms. In case of a rapid increase in CRP plasma levels following the 2nd session, a 3rd session was carried out another 24 h later. A specific CRP adsorber removed up to 79% of the original CRP. In each apheresis session, 6000 ml of plasma was treated via peripheral venous access. Primary study endpoint was myocardial infarction size as determined by Cardiac Magnetic Resonance Imaging (CMR) 2–9 days after STEMI.

 Aphereses sessions were well tolerated with no relevant side effects. Peak CRP plasma levels after STEMI ranged from 9 to 279 mg/l. The expected peak CRP level after AMI can be calculated precisely with 2–3 CRP quantifications during the first 24 h after the onset of symptoms. The regression coefficient for this analysis is 0.91. This mathematical step allows for the comparison of the CRP-apheresis group and the controls on the basis of their individual CRP peak levels. The statistical evaluation shows that the CRP concentration is significantly associated with the damage (infarct size, LVEF, circumferential strain) in the controls. This association was lost in the aphereses patients: they performed significantly better at all endpoints (infarct size, LVEF, circumferential strain) than the controls. The CRP apheresis significantly reduced myocardial damage. To our surprise, two apheresis patients had an infarct size of 0%.

 For the first time we find an unequivocal association between myocardial infarct size and the CRP concentration. This is in some respects a surprise, since the basic assumption in AMI is that the vascular occlusion leads to primary damage and the reperfusion to secondary damage, which would not have led one to expect such a clear dose-response relationship as that observed here. In addition, our results show a significant beneficial effect of CRP apheresis on myocardial infarction size and wall motion. Selective CRP apheresis is now being further evaluated as a therapeutic approach in the treatment of acute myocardial infarction in a registry (CAMI registry).

 Type of funding source: Private company. Main funding source(s): Pentracor GmbH


We study the long-term and dynamic relationship between de jure and de facto judicial independence using a large panel dataset covering 50 countries over a period of 50 years. Our analysis shows a negative relationship between these variables, a sharp contrast to the prevailing theoretical view in the literature. However, the magnitude of the relationship is small. The negative association between the two variables is driven by OECD countries, whereas a positive one can be found for non-OECD countries. We discover no evidence of reverse causality running from de facto to de jure judicial independence.


Abstract Background: Supplementation of folic acid by pregnant mothers is thought to lower the risk of autism spectrum disorders (ASDs) in the offspring. Folic acid is taken up by cells via receptors with high affinity for folate and reduced folic acid derivatives. However, this is blocked by the presence of folate receptor autoantibodies (FRAA). Cerebral FRAA have been detected with high frequency in children with ASDs, suggesting the existence of a link between folic acid uptake and disease aetiology. Methods: We investigated the frequency of FRAA in serum samples from 40 children with ASDs and 42 gender- and age-matched children with typical development (TD). Serum FRAA concentrations were measured by enzyme-linked immunosorbent assay. Results: We found a significant difference in the frequency of serum FRAA in the two study cohorts. Serum FRAA were present in 77.5% (31/40) of children with ASDs compared with 54.8% (23/42) of TD children (p = 0.03746, Fischer's exact test). Thus, serum FRAA are more prevalent in children with ASDs than in TD children. Conclusions: Our data suggest that children with ASDs may have defects in folic acid absorption that play a role in the onset of ASDs.


Gas turbine combustor liner (12) is closed first end adjacent to the upstream end of the combustor (13) and a second end adjacent to the downstream end of the combustor (15) vital hot side (36), comprising a shell further comprises a cold side (38) and the central axis therethrough. As multiple small and densely spaced film cooling holes (44) are formed in the shell and air is flowing therethrough film cooling holes to form a cooling film along the hot side of the shell Become. Each cooling hole has a diameter not uniform when extending through the shell. Specifically, each cooling hole has a first opening having installed and the first diameter to the cold side of the shell (38) is installed in the hot side (36) of the shell and a second diameter and a second opening having a second diameter of the second opening is larger than the first diameter of the first opening. The shape of each cooling hole is preferably substantially frustoconical. .The


Background: Over the past decade there has been an increased focus on the link between the history of preeclampsia and cardio metabolic syndrome a danger signaling event. The impact of this event is now becoming alarming in developing countries but data is scanty. Hence the need to collate information in Ghana. Aim: To compare cardio metabolic profile of preeclampsia before and after 34 weeks in Ghana Methodology: The nested case control study was located at the Obstetrics and Gynecology department of the Korle-Bu Teaching Hospital (KBTH). One hundred and sixty-four (164) consented subjects were recruited after ethical clearance was obtained and structured questionnaire administered to them. Four (4) ml blood and 5 mL urine samples were taken for biochemical analysis and urinalysis respectively. Randox automated chemistry analyzer was used to quantify blood chemistry. The data was captured as protected health information (PHI) and analyzed with SPSS version 18. Results: In preeclampsia, increased cardio metabolic scores before term were associated with low birth weight while lactate dehydrogenase (LDH) increased before 34 weeks and rather decreased after 34 weeks. Systolic blood pressure (SBP), white blood cells (WBC) and aspartate transaminase (AST) increased as well in PE clients while platelet (PLT), low density lipoprotein (LDL) and birth weight decreased when these variables were doubly stratified by weeks of gestation and cardio metabolic profile. Conclusion: Among preeclampsia, increased cardio metabolic profile before term were associated with low birth weight. Correspondence to: Ababio GK, University of Ghana SBAHS, Department of Medical Biochemistry, Accra, Ghana, E-mail: firstname.lastname@example.com


The study reported herein concerns itself with the isolation of melaninless mutants of S. antibioticus, ATCC, 3723, and with the demonstration that at least one of the sites of mutation involves that of the enzyme, tyrosinase.


25 years later after the catastrophe, which occurred as a result of the accident at the Chernobyl nuclear power plant, the world shuddered from a new tragedy in Japan at the nuclear power plant Fukushima-1. The experience of our country, methods and techniques of zoning radiation contaminated territories, determining areas of evacuation, exclusion and resettlement were accepted by the legislation of other countries, including Japan. More than 7 million people affected by these disasters live in ecologically unsafe areas, health and wellbeing which depends largely on the degree of legal regulation of these lands. There is no legal definition of ecologically unfavorable territories. The radiation-contaminated areas are one type of ecologically unfavorable territories. Their regime is regulated by separate laws, usually the social orientation. This is, first of all, the federal law on may 15, 1991 «On social protection of citizens exposed to radiation due to the accident at the Chernobyl nuclear power plant». That is why it is necessary to create a special legislation regulating the legal regime of ecologically unfavorable territories, including contaminated, because the present legislation is outdated, does not provide safety of the population and does not contain an effective system of rehabilitation measures for the recovery of these areas.


Living in the era of globalization and the Internet, the demand for faster innovationcycles is increasing. Thus companies have the aim to explore new innovation strategies.Therefore the basis of th ...


There is the conviction that the cradle of the lover's couple Aphrodite and Adonis was to be placed at Byblos, both in the city and at the springs of the river Nahr Ibrahim – Adonis, where the late tradition locates the «tomb of Adonis » in the cave of Afka or the place of the hierogamia of Aphrodite with Adonis. However, the Latin authors insist on Adonis and Aphrodite being in the sanctuaries of Cyprus. We can state that the Cypriot identity of Adonis goes back to the Ptolemaic era. We have two mythological nuclei in two distinct geographical areas that require the verification through the archaeological evidence. Two testimonia claim that the cult of Adonis was a proper feature of the sanctuary of Aphrodite at Amathus, where he might have had the priority. His presence is hinted at by the main testimonium on the cults on the acropolis of Amathus : Ovidius mentions in the Metamorphoses an altar of Juppiter Hospes, «at the entry of the householdings » of the Amathusians, called Cerastes. Then he explains the aition of the sacred prostitution at Amathus, to be acknowledged on the destiny of the girls called Propetidae. Venus punished both the Cerastes for the human sacrifices, turning them into bulls, and the Propetidae for their impudence, transforming them into «rocks » . The Roman Temple of Aphrodite Amathusia (100 A. D.) does not have an altar. Instead, in the place of the altar there is an underground cavity with a chamber, with some twenty circular holes on the surface. This must be the «tomb of Adonis » beneath the «Gardens of Adonis», whereas the «fondation en equerre » must correspond to the precinct of Juppiter Hospes, perhaps «accompanied » in a yet undefined place by the Propetidae. Ovidius did not mention Adonis in that context. He closes the whole excursus with the love of Venus for Adonis, followed by his death and the mourning of Venus for him. Since the Propetidae, identified in the form of stelae chalcosmaragdae, are to be recognized at the entrance of the Gate North (Building 16 during the Ptolemaic era and Building 17 in Imperial Times), we may wonder whether there was a literary cognition of a double archaeological structure or simply a topographical fusion, reproduced by the three complementary testimonia.


The application of Virtual Reality (VR) technology to the field of urban planning and design is still in the primary phases,which means that the VR technology has not been integrated into the planning and design process by urban planners. Therefore,the technical method has to be studied for urban planning and design aided by VR in real-time. Taking the demand of urban planning and design practice into account,the technical method,which includes technical application characteristics and typical application process,was studied in the paper for urban planning and design aided by VR in real-time. Based on this research,the technical application characteristics consist of not only immersion and interaction,as well as 3D visualization,easy edition,and professional analysis. And the typical application process is composed of four aspects,such as VR system selection,VR scene construction,VR function integration,and professional analysis based on VR system. All the technical characteristics and the typical application process have to be considered during the whole periods of urban plan- ning and design.


Abstract Objectives: To provide estimates of the numbers of cognitively impaired and physically disabled elderly people in England and Wales, subdivided by a range of sociodemographic, dependency, care receipt, and survival variables, to support debates on the form and funding of health and welfare programmes. Design: Interviews at baseline and 2 year follow up plus data on resource use extracted from records for those with disability. Subjects: 10 377 people aged 65 years and over in Cambridgeshire, Newcastle, Nottingham, and Oxford. All estimates weighted to population of England and Wales in 1996. Results: 11% of men and 19% of women aged 65 and over were disabled, totalling 1.3 million people; 38% of these were aged 85 or over and a similar percentage were cognitively impaired. Overall, more than 80% of elderly disabled people needed help on at least a daily basis. Over a third of people with limitations to daily activity living in private households were wholly or partly dependent on formal services for help. 63% of disabled elderly people used acute hospitals during the 2 year follow up, 43% as inpatients. 53% of those with cognitive impairment and limitations to daily activity were living in institutions. Conclusions: Very elderly people and those with cognitive impairment make up a large proportion of those in need of long term care. A large proportion of even the most disabled elderly people currently live outside institutions and depend on formal services as well as informal care givers. Disabled elderly people use acute hospitals extensively, underlining the interrelations between acute and long term care.


Report presenting an experimental investigation in the transonic blowdown tunnel to determine effects of center-of-gravity location on the transonic flutter characteristics of a 45 degree sweptback-wing plan form of aspect ratio 4.0 and taper ratio 0.6. Solid-construction models with streamwise NACA 65A004 airfoil sections and center-of-gravity locations at three different chords were fluttered at a range of Mach numbers.


Millions of rural workers have entered the big cities since the reform andopening up policy was put in place.However,due to the system of regis-tered permanent residency their children don't enjoy the same treatmentas residents of the city do.Finding a solution to this problem has attractedmany people's attention.What is the situation these children face in re-ceiving an education in Beijing?


Abstract:In the years since Indonesian independence, English-language works have dominated studies of Indonesian Chinese. A brief survey of influential researchers and their topics since Indonesian independence traces changes in scholarly interest from citizenship and assimilation to regional diversity, culture and identity, economic activity, religion and literature. Increasingly, researchers are themselves Indonesians and other Asians, and their home institutions range from Western countries to Southeast Asia.


ABSTRACT Vitamin D deficiency rickets occurs in sunny countries, mainly due to man-made environmental factors associated with avoidance of sunshine. This situation can be prevented by more health e...


Due to the widely use of frequency reuse factor one in the current and future wireless cellular systems,multi-cell interference has become a key factor constraining the system throughput.Coordinated multi-point transmission(CoMP) can efficiently reduce the interference in multi-cell system,thus improving the cell edge throughput.As a realization of CoMP,interference alignment (IA) attracts wide attention recently,which can obtain the optimal transmitting degree of freedom in multi-cell systems.A novel optimized precoding scheme is proposed for the downlink interference channel of cellular multi-input multi-output(MIMO) system.The precoding matrixes in the proposed scheme are designed by selecting the precoding vectors which are closest to the maximal eigen-channels, which improves the channel condition of the desired signal and strengthens the desired signal,in order to achieve a higher system throughput.Simulation results show that the proposed scheme can improve the throughput of the MIMO system significantly,especially for the case that the channel is spatial correlated.


Waste glass has potential for use in building materials, for example, as an aggregate replacement, a filler in concrete, or a cement replacement. Finely ground glass powder (particle size of less than 38 µm) can be used as a pozzolan material in concrete because of its high reactive silica content. This paper studied the properties of concrete containing finely ground glass powder (approximate particle size, 12 - 15 µm) of admixture Type D following ASTM C494. The fresh concrete's compressive strength, ability to resist chloride penetration, and free drying shrinkage were evaluated. The experiment showed that using 10% or 20% glass powder reduced the workability of fresh concrete and accelerated its setting time. However, concrete containing 10% finely ground glass powder exhibited greater compressive strength and improved resistance to the penetration of chloride ions than normal concrete and concrete containing fly ash at the same replacement level. Concrete with 10% glass powder also had lower shrinkage than normal concrete and concrete containing fly ash but higher shrinkage than concrete with 10% silica fume.


: The purpose of this study was to investigate the property of hydroxyapatite (HA)/gelatin hydrogel (GH) composite granules as a scaffold and controlled-release carrier of basic fibroblast growth factor (bFGF) for bone regeneration. HA granules and GH microsphere at various weight ratios to the HA granules were mixed. The composite provided the controlled release of bFGF in vitro . The critical-sized bone defects of 6 mm diameter were created in the skull of New Zealand white rabbits and the composite granules with or without incorporated bFGF, were implanted into the defects. Bone regeneration and were evaluated by computed tomography and H-E staining. The composite granules incorporating bFGF promoted significantly higher bone regeneration at the defect site as compared to the bFGF-free composites. Further, the amount of new bone increased in proportion to the amount of GH microspheres incorporated into the composite. We conclude that the bFGF-impregnated HA/GH composite granules is useful for bone regeneration.


Recently, the great tide of globalization has caused MA J.S.D. (Doctor of Science of Law), Columbia University School of Law; Attorney at Law; CFA (Chartered Financial Analyst). This Article is based on a chapter of J.S.D. dissertation submitted to Columbia University School of Law. It would not have been possible to complete this Article without the input, guidance, and support of many individuals. Most of all, I thank my parents and brother for their endless support, trust, and sacrifice. I also thank my mentors at Columbia University School of Law—Professors Merritt Fox, Jeffrey Gordon, Curtis Milhaupt, and Katharina Pistor—for their invaluable advice and insightful comments. It was truly my privilege and honor to have an opportunity to conduct research with these distinguished professors whom I respect and admire. I thank my colleague, Professor Douglas Levene for his great comments and advice as well. In addition, I thank Chancellor Wen Hai at Peking University in Shenzhen, Dean Stephen Yandle and other faculty members at Peking University School of Transnational Law, Chancellor Jeffrey Lehman at New York University Shanghai, Professor Jesse Fried at Harvard University School of Law, Professors Bok Ki Hong, Sung Tae Kim, Hyun Yoon Shin, and Doctor Nansulhun Choi at Yonsei University School of Law, and Judge Sang-Koo Park for their advice and moral support. In addition, my thanks go to Danlin Chang, Xiangmei Han, Yiseul Kim. Jie Lin, Jie Yin, and Zhaoke Zhu for their excellent assistance. I appreciate the efforts and comments of editors from the Northwestern Journal of International Law and Business as well. Northwestern Journal of International Law & Business 33:619 (2013) 620 corporate insiders. Controlling shareholders may be more interested in a control premium than severance pay. The transplanted pill could enhance a controlling shareholder's negotiation leverage and, as a result, the control premium. However, when a control premium should be shared with nondominant shareholders by law or social norm, controlling shareholders are likely to be reluctant to initiate M&A activities in the first place. On the other hand, when controlling shareholders are allowed to take a substantial fraction of control premium, it cuts directly against a core rationale of adopting the pill, i.e., protecting weak non-dominant shareholders.


Residual stress caused by magnetic field treatment is studied through magnetostriction investigation.The external magnetic field is carried out for both stress relief and magnetostriction at the same time.Samples of steel 45 are produced by tungsten inert gas welding and different heat treatment temperature and time are used to modify stress levels.The magnetostriction in the magnetic treatment process is recorded and residual stresses before and after the action of magnetic are compared.Experiment results shows that magnetostriction behaviors with different stress levels are different obviously.However,a good coherence exists between the relative change of magnetostriction and that of residual stress.Thus residual stress relief during the magnetic treatment can be evaluated by magnetostriction investigation conveniently.To explain the relationship between magnetostriction and stress level,energy differential equations are constructed and energy boundary conditions are modeled.The results deducted from the established equations show that the product of magnetostriction variation caused by pulsed magnetic field and residual stress in macro scope is constant,which agrees well with experiment results.


Severe cyclic thermo-mechanical operating conditions during delayed coking can cause damages in the form of bulging and cracking in coke drums. As a result, the industry has to perform costly repairs and maintenance shutdowns. Therefore, it is important to understand the damage and failure mechanisms of the coke drums and to achieve more reliable coke drum design solutions. This paper explores alternative selections of clad and base material combinations for coke drum applications based on material property data provided in ASME Boiler & Pressure Vessel Code, Section II - Materials. Finite element analyses are carried out by simulating two critical loading scenarios in the coke drum operation cycle, i.e. the heating up and quenching stages. The analysis results show that the major achievement in lowering the stress level in the clad layer is due to matching of the coefficients of thermal expansion between clad and base materials. In addition, the finite element analyses indicate that the differences in Young's modulus values play an important role in the variation of maximum stress in the coke drum shell during the quenching stage. Among eleven pairs of the clad and base material combinations studied, the combination of SA302-C as the base and nickel alloy N06625 as the cladding material is recommended.© 2012 ASME


ITS Services use various wireless technologies such as 2G cellular, 3G cellular, and Wi-Fi, etc. The main purpose of 3G or Wi-Fi is to deliver to the customers the information such as traffic and weather info, etc. Then we need to combine the wireless media. Application is implemented on the notebook or embedded board. Users may select wireless media in manual or automatic mode. Service can be supported by WLAN initially. After the terminal disconnects WLAN, cellular network is connected automatically or by the user's request. It is very useful for ITS or Telematics services to be supported with cheaper cost of wireless media.


The optical waveguide is the fundamental element that interconnects the various devices of an optical integrated circuit, just as a metallic strip does in an electrical integrated circuit. However, unlike electrical current that flows through a metal strip according to Ohm's law, optical waves travel in the waveguide in distinct optical modes. A mode, in this sense, is a spatial distribution of optical energy in one or more dimensions that remains constant in time. In this chapter, the concept of optical modes in a waveguiding structure is discussed qualitatively, and key results of waveguide theory are presented with minimal proof to give the reader a general understanding of the nature of light propagation in an optical waveguide. Then, in Chap. 3, a mathematically sound development of waveguide theory is given.


Objective To find out a reasonable solution for the secondary pseudo-hump nose deformity after a traditional nasal septum remedy through the research on the septum reengineering surgery.Methods Autologous osteochondral can be applied to make nasal septum repaired and then to the purpose of correcting pseudo-hump nose.Results The dorsal nasal septum curve is fluent with a good recovery,stable structure and clear breathing;besides,there is no untoward effect and postoperative complications.Conclusions A secondary pseudo hump deformity will occur after the traditional septum orthopedic surgery.So the pure prosthesis plastic repairing effect is not good.Up to now,the most reasonable method is autologous cartilage for the deformity septum reengineering plastic repair.


A key challenge to researchers involved with geological storage of CO2 has been to develop an appropriate methodology to assess and compare alternative CO2 injection projects on the basis of risk. Technical aspects, such as the risk of leakage and the effectiveness of the intended reservoir, clearly need to be considered, but so do less tangible aspects such as the value and safety of geological storage of CO2, and potential impacts on the community and environment. The RISQUE method has been applied and found to be an appropriate approach to deliver a transparent risk assessment process that can interface with the wider community and allow stakeholders to assess whether the CO2 injection process is safe, measurable and verifiable and whether a selected alternative delivers cost-effective greenhouse benefits. In Australia, under the GEODISC program, the approach was applied to assess the risk posed by conceptual CO2 injection projects in four selected areas: Dongara, Petrel, Gippsland and Carnarvon. The assessment derived outputs that address key project performance indicators that: are useful to compare projects; include technical, economic and community risk events; assist communication of risk to stakeholders; can be incorporated into risk management design of injection projects; and help identify specific areas for future research. The approach is to use quantitative techniques to characterise risk in terms of both the likelihood of identified risk events occurring (such as CO2 escape and inadequate injectivity into the storage site) and of their consequences (such as environmental damage and loss of life). The approach integrates current best practice risk assessment methods with best available information provided by an expert panel. The results clearly showed the relationships between containment and effectiveness for all of the four conceptual CO2 injection projects and indicated their acceptability with respect to two KPIs. Benefit-cost analysis showed which projects would probably be viable considering base-case economics, greenhouse benefits, and also the case after risk is taken into account. A societal risk profile was derived to compare the public safety risk posed by the injection projects with commonly accepted engineering target guidelines used for dams. The levels of amenity risk posed to the community by the projects were assessed, and their acceptability with respect to the specific KPI was evaluated. The risk assessment method and structure that was used should be applied to other potential CO2 injection sites to compare and rank their suitability, and to assist selection of the most appropriate site for any injection project. These sites can be reassessed at any time, as further information becomes available.


are ordered, a typical response might be, &dquo;As a follow-up to see what the white count is doing&dquo; or &dquo;There were 15 bands yesterday, but the baby is stable&dquo; or &dquo;Just to see what the baby's chest film looks like today.&dquo; When I ask for a specific clinical indication for such tests, I am often greeted with blank stares and perhaps the statement that &dquo;We are looking for any changes&dquo; or &dquo;Just to follow up.&dquo; No doubt we have all wondered about the utility of certain routine clinical labora-


The ability of the sepiolite mineral to intercalate CO2 molecules inside its channels in the presence of different alkaline cations (K+, Na+ and Li+) has been studied by classical Molecular Dynamics simulations. Starting from an alkaline-free sepiolite crystalline model we built three models with stoichiometry Mg320Si440Al40O1200(OH)160X+40•480H2O. On these models, we gradually replaced the water molecules present in the channels with carbon dioxide and determined the energy of this exchange reaction as well as the structural organization and dynamics of carbon dioxide in the channels. The adsorption energy shows that the Li-containing sepiolite mineral retains more carbon dioxide with respect to those with sodium and potassium cations in the channels. Moreover, the ordered patterns of CO2 molecules observed in the alkaline-free sepiolite mineral are in part destabilized by the presence of cations decreasing the adsorption capacity of this clay mineral.


Recent advances in machine learning have enabled the training of increasingly complex information retrieval models. This dissertation proposes principled approaches to formalize the learning problems for information retrieval, with an eye towards developing a unified learning framework. This will conceptually simplify the overall development process, making it easier to reason about higher level goals and properties of the retrieval system. This dissertation advocates two complementary approaches, structured prediction and interactive learning, to learn feature-rich retrieval models that can perform well in practice.


Second and third graders' competence to integrate knowledge of their ability and effort, as they would function in the child's success on a reading task, was examined. Forty adults were also asked to evaluate the effects of ability and effort on the children's future success. The children treated the negation and reciprocal relationships among the ability and effort attributes consistently and in ways not significantly different from the ways adults evaluated the effects of the child's effort and ability on success and failure.


A common dilemma facing governments around the world is how to meet the sizeable fiscal costs of providing and maintaining infrastructure networks. Over the past decade, developed and developing countries have looked to fiscal rules, budgetary reforms, tax policy and administration measures, public-private partnerships and other innovative financial instruments to raise additional finance for infrastructure investment. This paper looks at the range of options for raising the financing to meet Tanzania's infrastructure needs. It begins with a brief survey of the evidence on the relationship between infrastructure, public investment, and economic growth, and then goes on to consider the case for additional infrastructure investment in Tanzania. The second part of the paper looks at five broad options for mobilizing additional resources to meet Tanzania's infrastructure needs: (i) direct private investment and PPPs, (ii) expenditure reprioritization and efficiency, (iii) domestic revenue mobilization, (iv) external grants and concessional financing, and (v) sovereign borrowing on domestic or international credit markets. The paper concludes with some general recommendations on what combination of the above approaches might be suitable for Tanzania.


Stability of Vera-cell-adapted rinderpest vaccine virus with 2 different stabilizers, viz. 5% lactalbumin hydrolysate (LAR) plus 10%, sucrose (LS stabilizer) and 5% LAH plus 10% lactose (LL stabilizer), was tested lit various temperatures. At 4 o C, no loss in infective titres was found after 3 months of storage. At 25 o C on storage for 29 days, loss of infectivity was nonsignificant. A significant (P < 0.05) linear decline in the titres was observed when stored at 37° C for 21 days as well as at 45° C for 8 days. Based on declining degradation curves observed at different temperatures, the vaccine is expected to reach the minimum W.H.O. requirement of 2.5 log 10 TICD 50 after storage for approximately 305 days (LS) and 123 gays (LL) at 25°C; 28 days (LS) and 48 days (LL) at 37° C; and 3 days (LS) and 7 days (LL) at 45° C. Stabilizer LL was10und to be marginally superior to LS at 3 r and 45° C.


In this study, the barrier properties, crystalline structure and morphology of pullulan–sodium alginate-based films were investigated. Among the tested samples, pure pullulan films exhibited the lowest water vapor permeability and oxygen permeability values (7.053 × 10−6 g.m/Pa.h.m2 and 0.48x10−6 mL.mm/m2day.pa, respectively). Incorporating pullulan into alginate, the absorbance bands of COO− groups shifted significantly to higher wavenumbers (1,640 and 1,413 cm−1, respectively). This could be attributed to the disruption of intermolecular hydrogen bonds present originally between the carboxylic groups caused by added pullulan. The diffractogram of pullulan films indicated that pullulan was a fully amorphous polymer, whereas that of sodium alginate exhibited semi-crystalline features. Furthermore, the morphology of pullulan–alginate-based film was studied by atomic force microscopy. Roughness parameter (Rq and Ra) values increased significantly with the incorporation of alginate content into pullulan.

Practical Applications

Because pure pullulan, alginate and their blend film are highly water soluble, transparent, tasteless, odorless and heat sealable and poses low permeability to oxygen, they could potentially be a secondary packaging material for beverage products such as instant coffees and cocoa.


Inactivation of the BRCA1 and BRCA2 breast cancer susceptibility genes has been reported to occur via a germ‐line mutation of one allele and a somatic loss of the remaining wild‐type allele. We investigated the genetic mechanisms behind the second event in breast tumors from 17 BRCA1 and eight BRCA2 germ‐line mutation carriers, as compared with 21 sporadic breast tumors. Microsatellite markers intragenic or in close proximity to both genes were used to analyze imbalances between the mutant and wild‐type alleles. The actual and relative gene copy numbers were scored by fluorescence in situ hybridization (FISH) analysis of tumor cells using locus and centromere specific probes. All but one of the informative BRCA1 and BRCA2 tumors exhibited allelic imbalance and loss of the corresponding wild type allele. In contrast to sporadic tumors, however, where allelic imbalance at the BRCA1 and BRCA2 loci correlated well with relative copy number losses by FISH, a simple reduction to a single copy (average copy number ratio 2:1) was found in only two BRCA1 (12%) and four BRCA2 (50%) tumors. The majority of BRCA1 and BRCA2 tumors showed a copy number reduction (relative to reference probe with ratios 4:2, 3:2, 4:3) at corresponding loci, suggesting that a specific physical deletion of the wild‐type BRCA gene allele has been followed by a duplication of the remaining mutant allele via polyploidization. Several tumors contained multiple copies of BRCA1 and BRCA2 genes without relative copy number changes, implying that loss of wild‐type alleles is executed by alternative mechanisms such as mitotic recombination, non‐disjunctional chromosomal loss with or without reduplication, or by gene conversion. A paradoxical relative copy number gain of the mutant allele was evident in three BRCA1 tumors (18%), which could be of biological relevance if a dominant negative or gain‐of‐function model was ascribed for certain BRCA1 mutants. Our results indicate that complex genetic alterations are operational at the BRCA1 and BRCA2 loci in tumors from genetically predisposed individuals. Genes Chromosomes Cancer 28:432–442, 2000. © 2000 Wiley‐Liss, Inc.


1H NMR line shapes, obtained at low temperatures (T<5 K), are reported for CH3Br, CH3CD2Cl, and CH3CD2Br molecules enclathrated in the heavy water clathrate hydrates, and for CH3CD2I and CH3CCl3 molecules enclathrated together with D2S, in the heavy water double clathrate hydrates. Line shapes for CH3Br and CH3CCl3 are characteristic of very fast and slow tunneling, respectively. Those obtained for the ethyl halides indicated intermediate tunneling rates. To account for the latter line shapes it is necessary to include a distribution in tunneling frequencies in the Apaydin and Clough line shape calculation. Satisfactory simulated spectra are given by a log‐normal distribution. The methyl group rotational barrier heights derived from the tunneling frequencies for a threefold sinusoidal barrier can be correlated with the guest molecule dimensions relative to the size of the clathrate hydrate cage.


We report two cases of water intoxication in adolescents. In case 1, an 18yearold boy with mild mental retardation 5 months after cadaveric kidney transplantation due to bilateral kidney hypoplasia presented with hyponatrae mic seizures and a sodium level of 119 mmol/L. He was normotensive at the time of the convulsions. His diuretic treatment was significantly reduced the day before the occurrence of the seizure because of high urine output. The dosage of furosemide was reduced from 200 to 120 mg/day, and hydrochlorothiazide (75 mg/day) was suspended. He was instructed to lower oral intake proportionately, but he drank 2.5 L of water in 2 h, which caused dilutional hyponatraemia. The patient was treated with hypertonic saline, and his serum sodium normalized within 36 h. In case 2, a 14yearold boy with attention deficit hyperactivity disorder was admitted to the hospital because of a disorder of consciousness of unknown aeti ology. His current medication included the serotonin norepinephrin reuptake inhibitor (SNRI) atomoxetine hydrochloride and the antihistamine levocetirizine. He was confused, disoriented to the time and place and scored 10/15 on the Glasgow Coma Scale. His sodium level on admission was 123 mmol/L. A brain CT showed neither intracranial haemorrhage nor ischaemia, and liquor anal ysis was normal. He was treated with hypertonic saline, and hyponatraemia was corrected within 24 h. His clini cal condition improved significantly. We found excessive water ingestion as the reason for hyponatraemia in our patient. Excess free water is the most common aetiology of hyponatraemia in children. Whereas infants are usually affected by being fed dilute fluids (1), hyponatraemia in older children and adolescents evolves in association with voluntary drinking. Reported causes of hyponatraemia associated with an abundance of free water due to factors of surroundings include child abuse in children with excessive water ingestion (2), treatment with desmopres sin, endurance sport activity and iatrogenic hyponatrae mia in hospitalized children, which is usually associated with the administration of hypotonic fluids, often in a setting of an excess of nonosmotic ADH stimulation, e.g., nausea or pain after surgery (3). Both our patients were mentally ill, and it is known that children with psychiatric disorders are at higher risk of habitual polydipsia or voluntary excess drinking, which may result in dilutional hyponatraemia. The precise pathogenesis is not known, but a hypothalamic defect and medication side effects are suspected (4). Some psychiatric drugs such as SNRIs, serotonin reuptake inhibitors, tricyclic antidepressants, monoamine oxidase inhibitors and antipsychotics are associated with the syndrome of inappropriate antidiu retic hormone secretion (SIADH), which is accompanied by hyponatraemia and may lead to hyponatraemic encepha lopathy (HE) (5). Additionally, diuretic therapy reduction in case 1 contributed to hyponatraemia through a decrease in free water excretion. Generally, diuretic administration is one of the most frequent cause of hyponatraemia. In conclusion, we present two cases of HE in ado lescents. It should be emphasized that children with *Corresponding author: Jakub Zieg, Deparment of Pediatrics, Motol University Hospital, V Úvalu 84, 15006, Praha 5, Czech Republic, Phone: +420224432002, Fax: +420224432020, E-mail: firstname.lastname@example.com; and 2nd Faculty of Medicine, Department of Paediatrics, Charles University in Prague and Motol University Hospital, Prague, Czech Republic Marie Glombova: Department of Paediatrics, Kolín Hospital, Žižkova 146, 280 20, Kolín III, Czech Republic


A computational and experimental effort to investigate the e ow around rotor blades in hover is presented. The experimental analysis of the e owe eld in the immediate vicinity of the blade is supported by laser velocimetry (LV) performed on the three-dimensional velocity e eld around the bladesection and in its nearwake. A specie c LV data processingmethod based onthemomentumequationapplied around a bladesectionhasbeen developed to identify the contribution of the induced-drag component to the total sectional drag coefe cient. From the computational approach, some improvements to a vortex embedding full-potential method are checked by direct comparisons withtestdata. Comparisonsareperformed foroverallrotorairloads (thrustand torquecoefe cients ),localsectional coefe cients (liftanddragcontributions ),ande owe eldcharacteristics,includingthetipvortexpathandthespanwise circulation distribution.


The cerebellum has long been hypothesized to be involved in the storage and expression of motor memories. Work presented in this thesis demonstrates that optogenetically conditioned motor memories are stored in the cortical and nuclear regions of the cerebellum and expressed via disinhibition-mediated bursting of the cerebellar nuclei. Building on this observation we sought to determine the impact of preventing disinhibition of the cerebellar nuclei when cueing an optogenetically conditioned forelimb movement. By transiently increasing inhibition of cerebellar nuclei during high-speed video recordings of mice responding to a previously conditioned auditory cue, we demonstrated that preventing disinhibition of cerebellar nuclei prevents the expression of the learned forelimb movements. We conclude that disinhibition-mediated bursting of the cerebellar nuclei is necessary for retrieving the motor memory and the subsequent forelimb movement. Furthermore, this mechanism could be relevant for the expression of other kinds of motor memories.


This paper presents an interest rate model in which prices of fixed income assets depend on time to maturity and
two factors whose sum is equal to the instantaneous interest rate. Assuming correlation between both factors and
applying no-arbitrage conditions, we find a closed-form expression for bond prices. Implications for the term structure
of interest rates are analyzed. We also derive a closed-form solution for interest rate derivatives prices. This
expression is applied to price European options on discount bonds and can be applied to more complex derivatives.


This paper examines how treating equity conflicts in sports through an emphasis on compliance with Title IX of the Educational Amendments of '972 has actually hindered the mass adoption of gender equity in sport and proposes that applying the principles of diffusion would allow desired change to occur as an innovation and therefore be more readily accepted. The nature of such a paradigm shift is considered and support is offered for the perceived failure of the compliance approach due to violation of such theoretical principles as obtaining the understanding and support of administrators and providing real consequences for not changing behaviors. Societal reasons for the unacceptability of the compliance approach are identified, such as the need for the innovative idea to demonstrate an advantage and social support of the idea. In contrast, changing the paradigm to that of innovation is seen in terms of commonly accepte:_ equity principles. Possible system failure points for principle-based equity are identified including: (1) failure of the innovatinn to offer a relative advantage over existing practices; (2) failure of communication; (3) adoption failure; and (4) failure in innovation implementation. Application of equity principles is seen as permitting adoption in discrete stages and in an empowering climate for dealing with the more difficult resource issues. (Contains 14 references.) (DB) Reproductions supplied by EDRS are the best that can be made from the original document. ********************************************************************** * Diffusing of Gender Equity In Sport: Using Innovation vs Compliance Jody Brylinsky, Ph.D. Department of Physical Education 4024 Student Recreation Center Western Michigan University Kalamazoo, MI 49008 (616)-387-2677 PERMISSION TO REPRODUCE THIS MATERIAL HAS .BEEN GRANTED BY L):1 TO THE EDUCATIONAL NESOUPCA!, INF ORMATInN Cf NIIR IT RIC, 11111 flIl)",...X1 Hi 2 BEST COPY AVAILABLE The Diffusing of Gender Equity In Sport: Using Innovation vs Compliance


The invention discloses a preparation method of a hyperbranched dispersant. The preparation method comprises the following steps: preparing a solution containing (methyl) acrylic acid (ester), active substances, and hydrophobic macro-monomers for later use; preparing an oxidation-reduction initiator solution for later use; heating water to a temperature of 80 to 85 DEG C, adding 10 to 30% of the initiator solution into the water, after 5 to 10 minutes, simultaneously dropwise adding the mixed raw material solution and the rest initiator solution into the water; heating the mixed solution to a temperature of 85 to 90 DEG C, keeping the temperature for 1 to 1.5 hours; cooling to 40 DEG C or less, carrying out neutralization reactions, controlling the temperature below 50 DEG C at the same time, detecting the reaction product, and finally discharging the product if the product meets related standards. The hyperbranched dispersant is an aqueous dispersant, has the characteristics of environment-friendliness, safety, and excellent properties, and fulfills the technology blank in the domestic market. The hydrophobic macro-monomers have a good synergetic effect with carboxylic acids, furthermore, a proper temperature and an initiator are adopted so as to make the product reach a good dispersing and stabilizing effect, and the hyperbranched dispersant has an especially good dispersing effect on systems, which are difficult to disperse, such as carbon black, organic pigments, and the like.


The author in this paper reports the nursing of 7 cases of drug addiction treated with Gamma knife. The author argues that in order to ensure the smooth operation with Gamma knife, the focus of the pre operative nursing should be posed on planning an effective and reasonable nursing target according to the addict's symptoms and addictive phase, on personalizing and individualizing the nursing to meet psychological communications at treatment and on exiling the activeness of addicts.


Background: The neurodegenerative process in Alzheimer's disease (AD) and in the Lewy body variant of AD (LBV) patients is characterized by cholinergic dysfunction and deposition of amyloid β-peptide (Aβ) 1–40 and 1–42; however, the differential effects of Aβ species on the cholinergic system are not completely clear. Objective: To better understand the relationship between levels of Aβ1–40 and 1–42 on cholinergic deficits in AD and LBV patients. Methods: Levels of choline acetyltransferase (ChAT) activity and ChAT immunoreactivity in the plaques in the frontal cortex of patients with AD and LBV were correlated with Aβ1–42 and 1–40 levels determined by ELISA and with neuropathologic and neurologic markers. Results: Although the overall levels of ChAT activity were reduced in AD and LBV cases, there was a direct correlation with Aβ1–42 levels. Furthermore, patients with high Aβ1–42 levels had more abundant cholinergic dystrophic neurites in the plaques than cases with lower Aβ1–42. Conclusion: Aβ1–42 may also trigger cholinergic dysfunction by promoting aberrant neuritic sprouting.


Abstract In 2014, in response to a large volume of feedback from industry, the science community, and internal to Goddard Space Flight Center (GSFC), GSFC's Safety and Mission Assurance (SMA) Directorate began a transition to a risk-based implementation of SMA, departing from its longstanding practice of being primarily driven by a mostly static set of Mission Assurance Requirements. The transition started out with a pilot project involving risk-based acceptance of bare-printed circuit boards that was enormously successful, continued through a complete organizational transformation in 2015, and culminated with the baselining of formal Risk-Based SMA policy in 2016. This article highlights five major examples of successful implementation of Risk-Based SMA that have demonstrated not only substantial savings in project resources, but also the ability to achieve the lowest level of risk in developing and operating inherently risky systems.


Cotinus coggyria is a new type of color-leaf tree.It has very high gardens′ value.The different types of Cotinus coggyria′s branchs(including branches of part xylemal and whole xylemal and new unxylemal branches) are treated with different concentrations of IBA,and different cuttings′ rooting rate and amount of roots are determined.The result indicates that the cuttings′ rooting rate and amount of rootings treated with 1 500 mg/L IBA are the best;and in the rooted cuttings,the cuttings′ rooting rate and amount of rootings are best in cuttings of part xylem branches.


Abstract A coupled land–atmosphere climate model is used to investigate the impact of vegetation parameters (leaf area index, absorbed radiation, and greenness fraction) on the simulation of surface fluxes and their potential role in improving climate forecasts. Ensemble simulations for 1986–95 have been conducted with specified observed sea surface temperatures. The vegetation impact is analyzed by comparing integrations with two different ways of specifying vegetation boundary conditions: observed interannually varying vegetation versus the climatological annual cycle. Parallel integrations are also implemented and analyzed for the land surface model in an uncoupled mode within the framework of the Second Global Soil Wetness Project (GSWP-2) for the same period. The sensitivity to vegetation anomalies in the coupled simulations appears to be relatively small. There appears to be only episodic and localized favorable impacts of vegetation variations on the skill of precipitation and temperature simulatio...


Aim of this work is to study the reliability of the dielectric between cell control gate and drain contact. Conduction characteristics and reliability under high field stress are investigated. The large spread in this dielectric thickness because of mask misalignment makes the usual reliability procedures very difficult to be applied. Results relative to fast and long reliability measurements are discussed, proposing a method for the evaluation of the spread between control gate and drain contact. Moreover, this methodology allows a screening of the structures with a too critical mask misalignment, or with a poor dielectric quality which could cause memory failures during cycling


Studies have found great occurrence of injuries among football and futsal players, especially among female population. One of the most elite European female futsal championships is Italian Serie A. Besides quality of the Serie A, Italy can be proud of good organization of lower leagues and quantity of active female futsal players. In three divisions organized by national federation there are more than 4.000 active female futsal players. If you add all the amateur futsal leagues, number of active players is much bigger. The aim of this research was to enter the number, frequency, locality and the type of injuries, along with the consequences, among Italian female futsal players. Methods: sample was consisted of Serie A, C, D and amateur league female futsal players (N= 95) in the Veneto region. Players completed the questionnaire, consisted of morphological measures, training and competition information and information about types, locality, frequency and consequences of injuries during their career. Analysis of variance (ANOVA) was applied to calculate statistical differences in the number and types of injuries among groups. Results have demonstrated that the most common injury among Italian female futsal players is ankle sprain (42.14%), followed by the ligament injury and meniscus lesion (18.88%) and contusions (13.84%). Total of 159 injuries in 83 players (87.73%) were recorded. 78.31% of injuries were result of a trauma. 28.92% respondents suffered repeated injury. The highest number of injuries (61.45%) occurred during competition. Statistical significance (p<0, 05) has been shown in the number of injuries between groups and the number of knee injuries. Conclusion: the most common injury among Italian female futsal players is ankle sprain, followed by the knee injury. Significant differences have been shown among groups in the number of injuries occurred and the number of knee injuries. Training programs should be improved with the more frequent use of better preventive programs decreasing these types of injuries.


Summary form only given, as follows. A variety of 3D configurations for modeling helix TWTs is presented. Linear field theories are described for the dispersion equations for helix TWTs. These models include a sheath helix enclosed by a conducting shell with dielectric and vane loading in the gap between the helix and the shell. The dispersion equations so obtained are solved for parameters consistent with several experiments and compared with measured results. Good agreement for the dispersion and gain is found with the linear theories and the experiments. The nonlinear analysis and simulation code is an extension of the GATOR simulation to include the vanes and dielectrics. Comparisons between GATOR and the linear theories as well as the experiments are presented, and good agreement is found.


A magnet system comprising a 2 T superconducting solenoid for a target spectrometer and a large aperture dipole magnet for a forward spectrometer is being developed for the PANDA experiment at GSI. The inner radius of the solenoid coil is 1.1 m. The solenoid is of a split type to provide a warm bore between the coil parts for the target. An energy of 23 MJ is stored in the magnet. The Dipole Magnet will provide a bending momentum of 2 Tmiddotm. The magnet is of the "H-type" with a water-cooled winding. The paper covers magnetic field and forces calculations as well as strength analysis and description of the magnet system components and their implementation


A new oscillator neural network is proposed on the basis of a system of coupled complex Ginzburg-Landau equations (Uchiyama S and Fujisaka H 1997 Phys. Rev. E 56 99). It is shown that this network can retrieve fixed-point attractors, and has an excellent mathematical tractability (just as the Hopfield model) although the system has no Lyapunov function. We use self-consistent signal-to-noise analysis instead of the replica method to investigate the storage capacity, and demonstrate the usefulness of the present approach to the neural network exhibiting complex dynamical behaviours.


To solve multi-objective decision making problems, many of the traditional models have been proposed. But these models don't include all the possible preferences of decision maker. In this paper, we introduce the concept of weighted-objective similarity degree, and propose a new method of multi-objective decision-making based on weighted-objective similarity degree. We obtain some related properties and applications.


The paper evaluated the rationale why Nigeria and other African states have remained underdeveloped in the presence of huge natural resource endowment, when less endowed States have progressed considerably on the development scale. It adopted the MO Ibrahim leadership and development indices as a measure of human progress and the UNDP reports as the barometer of measurement. The focus was on Nigeria with analytical implication for other African states. Richard Joseph's 'prebendal and patrimonial' framework was used as the analytical perspective. The study revealed that contrary to the alibi that the global capitalism accounted for the slow pace of development in Nigeria and other African states, that 'Asian Tigers' with no natural endowment waded through this same international economic order to attain their current level of development. The absence of 'benevolent leadership, Prebendal and patrimonial politics were identified as part of the causal factors for the lack of development, even where Nigeria and other African state tended to be 'developmental states'. It recommended the benevolent and patriotic dictatorial leadership for Nigeria and African states as a panacea to Prebendalism and the pursuit of the processes of Sustainable Development for Nigeria and Africa. It upheld that the prize monetary reward from the MO Ibrahim foundation should serve as enough incentive for good governance in Africa. DOI: 10.5901/mjss.2016.v7n2s1p70


Philantrophy is a universal concept that exists far beyond time, but has since evolved due to technological advancement. The development of technology has changed the social behaviour and interactions between people, and consequently, so too has the concept of philanthropy and the way it now operates changed. The opportunity to reach and commit to philanthropy is made much possible by adapting the digital technology to ease the process. This paper seeks to examine the concept of digital philanthropy and the idea of Islamic ethics of technology, and to analyze the extent to which existing digital philanthropy conforms with Islamic ethics of technology to ensure that both are aligned. This paper employs qualitative methods through library-based research of relevant literature comprising of books, article journals, guidelines, and others. The study uses content analysis to derived facts from the relevant literature related to the topic. Based on the findings, the concept of digital philanthropy can be widened in its application so as not to confined it only to monetary aspects. The idea of philanthropy from the Islamic perspective encompasses more than financial issues. The practice of digital philanthropy should be in line with the principles of Islamic ethics of technology to achieve the objectives of the Shariah in promoting good and avoiding harm and evil.


The early months of the new school year are often marked by a familiar tale from parents: "The teacher says he can't come back to school until he sees a doctor and gets medication to help him calm down." Parent reactions to this demand by teachers vary from indignation to concern to a desire for a quick fix. Pediatric nurse practitioners (PNPs) are in a key position to help assure that the child suspected of having ADHD receives a thorough and appropriate evaluation and a comprehensive plan of care. Parent support and education through the processes of assessment, diagnosis, and development of an effective treatment plan are critical elements in achieving good outcomes for the child and family (Selekman & Snyder, 2000). Below are answers for questions parents ask frequently.


Background: Hypertension is a leading cause of morbidity and mortality globally. It is a well-known risk factor for an array of adverse cardiovascular outcomes. Obesity is considered as one of the major contributing factors to essential hypertension in humans. Obesity in itself is a risk factor for conditions like insulin resistance, hypertension, stroke, ischemic heart diseases, CHF etc. Undoubtedly in recent times we have achieved great advances in terms of management of hypertension but still we have miles to cover to have dominance over it. Gymnema sylvestre is a valuable indigenous herb. A number of animal and human studies have shown the potential role of Gymnema sylvestre (GS) as an anti-diabetic and anti-obesity agent. Methods: Adult Female Wistar rats, weighing between 150-200 gm, were included in the study. They were randomly divided into five groups with six rats in each group. High Fat Diet (HFD) was given for 4 weeks to induce hypertension in all the groups except group I which was fed with normal chow. Drugs along with respective diets were given to the rats for next 4 weeks by oral feeding cannula. Systolic blood pressure was measured by NIBP controller machine. Results: On feeding rats with HFD for 4 weeks the mean systolic blood pressure increased significantly. After giving drugs GS (100mg/kg), GS (200mg/kg) and Amlodipine (10mg/kg) to groups III, IV, V respectively for next 4 weeks, mean systolic blood pressure fell significantly (p <0.05) as compared to group II (HFD control group). At final evaluation at week 8 (as compared to Group 2) SBP got maximally reduced in Group 5 (35.1%) followed by Group 4 (26.4%), Group 3 (20.1%). On comparing Amlodipine standard (group 5) with other groups, a significant difference was found. This showed that Gymnema sylvestre reduced the elevated systolic blood pressure significantly but this anti-hypertensive effect was inferior to Amlodipine. Conclusions: The present study concludes that Gymnema sylvestre has a potent dose- dependent antihypertensive action but the effect is inferior to Amlodipine. Hence it can be used as an add-on to standard drugs for hypertension.


This paper is concerned with robust absolute stability of uncertain Lur'e systems of neutral type. Some delay‐dependent stability criteria are obtained and formulated in the form of linear matrix inequalities. The criteria cover some existing results as their special cases. Neither model transformation nor bounding technique for cross terms is involved through derivation of the stability criteria. Numerical examples show the effectiveness of the criteria. Copyright © 2007 John Wiley & Sons, Ltd.


Abstract Viscosities of aqueous solutions of 1-Propanol, 2-Propanol, t-Butanol, allyl alcohol and propargyl alcohol were measured at temperatures 30°, 35°, 40°, 45° and 50°C covering the whole range of composition. On addition of alcohols to water, viscosity increases rapidly. Except for propargyl alcohol, viscosities pass through maxima and then decline continuously as the addition of alcohol is continued. the heights of the maxima occuring between 0.2 and 0.3 mole fraction of alcohols are in the order, t-Butanol > 2-Propanol > 1-Propanol > allyl alcohol. Contrary to this, propargyl alcohol shows no such maximum. After the fast initial rise, the viscosity rises slowly and monotonically up to its pure state for this alcohol. the excess viscosities are found to be positive and large in magnitude. for all alcohols, excess viscosities show maxima in water-rich region. Shallow minima are observed for 2-Propanol and t-Butanol, each at the alcohol-rich end of viscosity curves, which disappear gradually with the...


Recently, Soft Morphological Filters have shown excellent performance in restoring noisy images. To add soft morphological filters in image processing chains and also to process image sequences in real time, it became a necessity to implement soft morphological operations in hardware. In this paper, FPGA architecture of grey-scale soft morphological filters is proposed. The architecture is based on a stack filter expression with some modification. The design can calculate soft morphological operations of greyscale soft morphological filters with structuring functions of any size and shape inside the structuring function's overall support. The filter architecture guarantees fixed processing time independent of the size and shape of the structuring function of the filter. Implementation results showed that the proposed filter architecture is suitable for real time applications.


Because of improving mobile platforms and faster 4G speed, the annual growth of mobile devices has exceeded 50%, and many catering enterprises have integrated services to make ordering and delivery more convenient for smartphone users. Thus, user satisfaction with new online food-delivery platforms and services needs to be explored and evaluated. Using an Importance–Satisfaction Model (I–S Model), this study applied 12 service elements obtained from previous studies and an in-depth discussion of experts and scholars to evaluate user satisfaction towards Foodpanda, the first online food delivery service provider in Taiwan. Questionnaires were distributed from June to July 2020 and 256 samples were collected. This study found that eight items fell within the "Excellent Area", one within the "Improvement Area" and three within the "Careless Area".


We obtained the structural diagram of the multilayer electromagnetoelastic actuator for nano science and engineering in contrast to electrical equivalent circuits of the piezotransmitter and piezoreceiver, the vibration piezomotor. In this work the structuralparametric model, the structural diagram and the matrix transfer function of the multilayer electromagnetoelastic actuator for nano science and engineering are determined.


The concept and factors of health services access are generalized,the theoretical model and assessment system of health services access is explicated,and the research process at home and abroad is introduced to raise strategies and recommendations to improve access to health services in China.


The present paper reports five species of the genus Metathrinca Meyrick from China,among which three species are described as new to science. The genital structures of the new species are figured. The type specimens are kept in the Department of Biology, Nankai University. 1. Metathrinca argentea, sp. nov. (Figs.1,2) This new species is closely allied to Metathrinca tsugensis (Kearfott), but can be distinguished from it by male genitalia: valva narrow, distally truncate; inner process at base of valva very long, exceeding costa. Holotype ♂, Mt. Jigongshan, Xinyang District, Henan Province, alt. 700 m, 13-Ⅶ-1997, leg. Li Houhun. Paratypes: 1♂,1♀, same data as holotype; 1♂, Mt. Meihua, Fujian Province, 21-Ⅶ-1988; 1♂,2♀♀, Wenqiuan, Yuexi County, Anhui Province, 5-Ⅷ-1995, leg. Hu Xiangfu; 1♂,13♀♀, Luxian County, Sichuan Province, 26-Ⅶ-1995, leg. Zeng Yongxing. 2. Metathrinca fopingensis, sp. nov. (Figs.3,4) This species is related to Metathrinca tsugensis (Kearfott), but differs from the latter in the following characters of male genitalia: valva narrower; cucullus concaved; inner process at base of valva relatively short, with a long slender process near its base. The new species is also close to Metathrinca intacta (Meyrick), but can be distinguished from it by forewing with distinct maculations; tegumen short and broad, aedeagus stout in male genitalia. Holotype ♂, Daguping, Foping County, Shaanxi Province, alt. 1000 m, 25-Ⅶ-1985, leg. Li Houhun. Paratypes 2♀♀,24-Ⅶ-1985, other same data as holotype. 3. Metathrinca meihuashana, sp. nov. (Fig.5) The new species is somewhat similar to Metathrinca ophiura Meyrick in appearance, but can be separated from the latter by the following characters of male genitalia: gnathos somewhat bulbously rounded, inner process at base of valva blunt apically, saccus short and small, penal sheath distally divided into two parts. Holotype ♂, Mt. Meihuashan, Fujian Province, 19-Ⅶ-1988. 4. Metathrinca tsugensis (Kearfott, 1910) Ptochoryctis tsugensis Kearfott, 1910, Can. Ent., 42:347; Meyrick, 1935, In Caradja Meyrick, Mater. Microl. Fauna Prov.: 83. Metathrinca tsugensis (Kearfott), Moriuti, In Inoue et al., Moths of Japan, 1:259, 2:208; Kanazawa, 1992, In Heppner et al., Lep. of Taivwan, 1(2): 67; Liu, 1981, Ico. Het. Sin., 1:21; Shen et al., 1988, Acta Agri. Univ. Jiangxi (treatise): 26. Hostplants: Tsuga sp., Abies sp., Picea sp. Distribution: China (Anhui, Jiangxi, Henan, Zhejiang, Taiwan), Japan. 5. Metathrinca intacta (Meyrick, 1938) Ptochoryctis intacta Meyrick, 1938, In Caradja Meyrick, Dt. Ent. Z. Iris, 52:14. Metathrinca intacta (Meyrick, 1938), Clarke, 1955, Catalogue of the Type Specimens of Microlepidoptera in the British Museum (Natural History) described by Edward Meyrick, 2:446. Distribution: China (Yunnan)


Reconstruction of large maxillofacial bone defects remains challenging even with diverse current treatment modalities. Silica-calcium phosphate nano composite (SCPC) is a resorbable bioactive bone graft material with a strong stimulatory effect on osteogenic gene expression of osteoblasts and mineralized tissue formation. In a prospective experimental study we investigated the ability of SCPC scaffold seeded with human adipose derived stem cells (ADSCs) to regenerate bone in a critical-size canine calvarial defect. Porous SCPC discs were prepared by powder metallurgy method. ADSCs were isolated from human breast adipose tissue, expanded in vitro and differentiated along osteogenic lineage. Bilateral critical-sized defects, 2.5 cm in diameter each, were made in the calvaria of 12 adult dogs. One calvarial defect was filled by either SCPC disc alone (Group I) or SCPC disc seeded with 2.5 x106 osteoblast-like cells (Group II) while other defect was left empty (ungrafted). Bone tissue regeneration and graft material resorption was evaluated 3 and 6 months postoperative using CT and histology. Calvarial defects grafted with SCPC alone or SCPC-Cell construct were grossly repaired while control ungrafted defect did not repair. Microscopically the newly formed bone in the grafted defects was compact and integrated with the surrounding host tissues. Near complete resorption of the graft material was observed. Histomorphometric analysis demonstrated higher bone surface area and more graft material resorption in defects grafted with SCPC-cell hybrid compared to SCPC alone.


A Brief Summary of Four Keynote Addresses.- Galileo: Status and Way Forward.- At the Crossroads: Civil and Security Issues Concerning Navigation Satellites in Japan.- The Future of the GPS Local Area Augmentation System (LAAS).- Complement and Augmentation of GPS from a Quasi-Zenith Orbit.- A GNSS Literature Review and a Navigation System for Future Space Vehicles.- Galileo System Architecture - Status and Concepts.- Europe's Challenges in Developing its Own Satellite Navigation System.- Cislunar Navigation.- Compatibility and Interoperability of GPS and Galileo: A Continuum of Time, Geodesy, and Signal Structure Options for Civil GNSS Services.- Galileo - The Essentials of Interoperability.- Inmarsat: An Approach for Integration of EGNOS and Galileo.- A Software Perspective on GNSS Receiver Integration and Operation.- GNSS Safety of Life Services: Towards a Safer and More Effective Use of European Transport Networks.- Testing the Dubai Virtual Reference System (DVRS) National GPS-RTK Network.- Network-based RTK-GPS for Nationwide High-accuracy Positioning and Navigation in Japan.- Measuring Galileo's Channel - The Pedestrian Satellite Channel.- A Challenging Navigation Environment - Indoor Applications.- Evaluation of EGNOS (GNSS-1) for Application in a Vehicle Driving Support System.- The Use of Global Navigation Systems in the Aviation Industry.- The Advent of Galileo in the European Air Navigation System.- The Need for, and Benefits of, Galileo Local Services.- ISAGNSS: Infrastructure for Spanish GNSS Activities.- Session 6 Discussion Groups.- A Combined Localisation/Communications System for Mountain Rescue Applications.- Automatic Guidance of Farm Vehicles.- Algorithms of a Complex Inertial and Satellite Navigation System for Aircraft.- GPS-based Clock Synchronization for Precision Time Management for LEO Remote Sensing Satellites.- Space Radiation Environment and its Effects on Satellite Navigation Systems.- Navigation Support through Intelligent Agents.- A Novel Signal Processing Scheme for a Next Generation GNSS Receiver.- Damage Caused by GNSS Signals in the Light of the Liability Convention of 1972.- Galileo System Test Bed Validation Algorithms.- Potential Criteria for the Assessment of a Future Public-Private Partnership for Galileo.- Qualification of EGNOS for Routine Operation.- Solutions to Increasing the Availability of GPS and Future Upgrades of the Satellite Navigation System.- Symposium Summary.


Genetic studies of F 2 progeny from a cross between Aegilops tauschii accessions AUS18913 and CPI110856 revealed that Gli-D t T1 is tightly linked with a γ-gliadin gene at the Gli-D t 7 locus located on the short arm of chromosome 1D. Acid-polyacrylamide gel electrophoresis (A-PAGE) used to examine the gliadins of this population revealed two genes that encode a ω-gliadin (T 1 ) protein and a novel γ-gliadin protein. The ω-gliadin (T 1 ) protein and the novel γ-gliadin protein cosegregated, while having 0.69 cM recombination with the other locus (Gli-D t 1). N-terminal sequences were used to further classify the proteins studied.


In this paper,we study the existence of at least two positive solutions for secondorder boundary value problems with integral boundary conditions by using Avery-Henderson fixed point theorem.The work is an extension of the previous results.