Model-Driven Architecture (MDA) developed by the Object Management Group (OMG) proposes three (or at least two) transformable models for system specification. The first one is a Computation Independent Model or CIM. The CIM is a model that should eliminate the gap between business people and software developers. Two other models are a Platform Independent Model (PIM) and a Platform Specific Model (PSM). The last two models specify the system structure and behavior according to the object-oriented paradigm and definitely are transformable. This chapter discusses the CIM. This model specifies domain information: business vocabulary, business rules, business knowledge, system requirements (in a broad sense), etc. This means ABstrAct


In 1905, an unnamed church official at Berthelsdorf, near Herrnhut in the Oberlausitz in eastern Germany, the home of the Moravian Church, wrote a letter of gratitude to Bruder Friedrich August Hagenauer, a long-serving missionary in the British colony of Victoria. In examining the history of the Moravians in Victoria within the fuller context of the greater history, practices, and religious beliefs of the Church, a story emerges of how the Moravians as self-declared "strangers in a strange land" constructed their own identity as foreign missionaries as they interacted with indigenous peoples, colonists, and government officials. The Moravian missionaries, as both cultural and religious outsiders, were not privy to the internal machinations of such structures, yet they were required to make themselves amenable to the laws of the land. This chapter presents an overview of how the other chapters of the book are organised.Keywords: Friedrich August Hagenauer; Moravian Church; Victoria


Objective To investigate the role of combined multislice CT pulmonary artery angiography(MSCTPA) and indirect CT venography in the diagnosis of venous throraboembolism(VTE). Materials and Methods Combined CT pulmonary angiog-raphy and indirect CT venography were taken in 87 patients with suspected thromboembolism, and calculate the diagnostic sensitivity , specificity, negative predictive and positive predictive. Results of indirect CT venography were compared with those of bilateral lower extremity Doppler vessel ultrasound (DVUS) from the popliteal bifurcation to the inguinal level, and calculate the diagnostic sensitivity, specificity, negative predictive and positive predictive. Results Among 87 patients examined, 32 cases had both pulmonary thromboembolism(PTE)and DVT, 8 had DVT without PTE, 22 had PTE without DVT in MSCTPA and 42 had DVT in DVUS. The sensitivity and specificity of indirect CT venography for femoropopliteal DVT, compared with Doppler vessel ultrasound, were 95.5% and 99.2% respectively. Positive and negative predictive values were 97.7% and 98.5% , respectively. Conclusion The combination MSCTPA and indirect CT venography of lower extremity allows a complete one-session evaluation in patients with suspected of having VTE. Other abnormal findings in the chest and legs can be found simultaneously.


The daily number of confirmed cases of influenza throughout Western Australia, at a particular point in space and time is modelled nonparametrically by assuming that the observation is generated from a mixture of Poisson distributions where the log of the expected value of each component in the mixture has a priori a stationary Gaussian Process priors (GPP). The weights attached to the components in the mixture are parameterised to depend upon factors which are specific to a particular point in space and time, such as the population density, the time of year, the current weather conditions, the age distribution and human movement patterns as well as the attributes of the virus. This mixture model serves two purposes. First it seeks to identify the spread of influenza at a point in space-time as belonging to one of a finite but unknown number of possible influenza propagation signatures. Second it addresses the issue that the space-time covariance structure for influenza counts is likely to be nonstationary, by attaching different weights to the mixture components at different points in space and ∗This paper was presented at the First International Workshop on Population Informatics for Big Data (PopInfo'15), Sydney, 10th of August 2015. Copyright of this work is with the authors †Corresponding author ‡Corresponding author time. This allows the covariance to change across spacetime. In this first study we focus on the data collected by a surveillance program run by Department of Health of Western Australia. Predictive distributions of influenza counts are obtained at a particular point in space and time, after accounting for the certainty surrounding the possible models as well as the uncertainty surrounding the parameters which prescribe these models. The multidimensional integration required to obtain these predictive distributions is performed using reversible jump Markov chain Monte Carlo (RJMCMC).


A microanalysis method which was based on gas chromatography-mass spectrometry(GC-MS) was established to identify compositions of fatty acids in 3 kinds of seed oil of sea buckthorn,including Yalishanda-12,Shiyou-1 and Qiuyisike×Chinese-Wucixiong.Fatty acids were qualitatively determined according to the standards of fatty oil by MS.The compositions of fatty acids in seed oil were calculated by peak area normalization.The results indicated that unsaturated acids(71.2%~76.0%) were rich in seed oil.The content of linoleic acid was highest with the range between 35.6% and 39.0%,α-linolenic acid was second with the range between 27.8% and 33.4%.


By analyzing the short-distance wireless communication technique based on Zigbee,a new method of wirelessly collecting gas information underground coal mine is put forward.The collecting device takes ARM hardware platform,embedded Linux software platform and Zigbee technique to receive gas information in wireless mode,thus effectively guaranteeing the personal safety.The paper mainly introduces the principle,hardware composing and software realization of the collecting device.


THE PHILOSOPHER WE are here to honour tonight has a unique distinction in the history of philosophy. There has never been in the history of the world a philosopher who was as much loved in his time and as world wide as Bertrand Russell. No other philosopher made himself so relevant to the concerns and the anguish ofhis time as Bertrand Russell. True, he did not develop a system, but every system merely takes a flash ofinsight and creates an elaborate fiction out of it. But I am not here to talk about Russell as a philosopher-I am not competent to discuss his achievements in the more recondite and technical fields of philosophy-but to speak of him as a moral influence, for the world has great need ofmen of this kind. He and Einstein (and one really has to think of them together) represented what is something almost new in world history. Ifwe look about for a successor to exercise a moral influence on the rather tangled and immoral activities of mankind, we have to recognize that the human race is very, very primitive. To exercise a moral influence over the human race requires, first of all, that you be associated with some tricks-a little bit of "circus" is required to capture the imagination and win the awe of mankind. Moses had the worst and the best of the Pharoah's sorcerers to prove his mettle, Jesus had to walk on water, and in our more enlightened age, we have much the same phenomenon, although it is in a somewhat more superficially subtle form. One of


Component sharing may look great in the boardroom but not in the showroom. Indeed, savings on research and development and production costs could be offset by a plunge in customer brand attractiveness. The central objective of this paper is to investigate consumer and market responses toward component sharing between brands. More specifically, by combining experimental with econometric studies, this paper investigates the impact of component sharing on customer evaluation of luxury, volume, and economy brands offered in a car manufacturer's vertical product line. An experimental study in which component sharing between automotive brands was made explicit aimed to understand the impact of brand combinations and type of sourcing on the evaluations of the two brands sharing components. This experimental study shows that the evaluation of luxury brands sharing with a volume brand suffers more than when a volume brand shares components with an economy brand. This experimental study was executed for two different brand combinations including one luxury, one volume, and one economy brand: (1) Audi, Volkswagen, and Skoda; and (2) Lexus,


The birth year‐dependent onset of breast cancer (BC) in BRCA1/2 mutation carriers suggests a risk‐modifying role for reproductive and life style factors. We therefore examined possible associations between these factors and age at diagnosis.


Heterogeneous transesterification of waste cooking oil (WCO) with methanol in the presence of heteropoly acid (HPA) catalyst have been investigated. The effect of different operation parameters such as methanol to oil molar ratio, catalyst loading, reaction temperature, and reaction time were evaluated. The 88.6% conversion was obtained at the optimum condition of 70:1 methanol to oil molar ratio, 65 ˚C reaction temperature, 10 wt% catalyst, and 14 h reaction time. The catalyst showed the high activity site and at least four times reusability. Meanwhile, this type of catalyst can significantly decrease the cost of pre-treatment, separation and purification processes.


Search for a heavy scalar boson decaying into a pair of Z bosons in the 2l2nu final state in CMS
A.Magitteri (Louvain)


Abstract : The objective of the contract was the development of a nonproprietary, low cost, production process for nylon obturators for the 105-mm M735 projectile that would give product performance equivalent to that obtained from current production machined from centrifugally cast nylon 6/6. Injection molding, using general purpose molding grade nylon 6/6 (DuPont Zytel 101L), was selected as the preferred process, based on cost analysis comparisons with compression and transfer molding. A single cavity, diaphragm-gate mold was designed and built. Molding cycles and post molding treatments were developed to minimize molded-in stress levels and to meet dimensional requirements after installation. Injection molded obturators met all the physical property requirements specified except for the water absorption value of 0.58 average vs maximum of 0.42. Installation on M735 projectiles was demonstrated successfully at ARRADCOM using modified standard procedures. Ballistic firing trials at -53 F, +70 F, and +145 F showed almost 1 to 1 correlation with control cast obturators.


Post-tensioned timber technology was originally developed and researched at the University of Canterbury (UC) in New Zealand in 2005. It can provide a low-damage seismic design solution for multi-storey mass timber buildings. Since mass timber products, such as cross-laminated timber (CLT), have high in-plane stiffness, a post-tensioned timber shear wall will deform mainly in a rocking mechanism. The moment capacity of the wall at the base is commonly determined using the elastic form of the Modified Monolithic Beam Analogy (MMBA). In the calculation of the moment capacity at the wall base, it is critical to accurately predict the location of the neutral axis and the timber compressive stress distribution. Three 2/3 scale 8.6m tall post-tensioned CLT walls were experimentally tested under quasi-static cyclic loading – both uni-directional and bi-directionalin this study. These specimens included a single wall, a coupled wall, and a C-shaped core-wall. The main objective was to develop post-tensioned C-shaped timber core-walls for tall timber buildings with enhanced lateral strength and stiffness. To better understand the timber compressive stress distributions at the wall base, particle tracking technology (PTT) technology was applied for the first time to investigate the behaviour of the compression toe. Previous post-tensioned timber testing primarily used the displacement measurements to determine the timber compressive behavior at the wall base or rocking interfaces. However, by using PTT technology, the timber strain measurements in the compression zone can be much more accurate as PTT is able to track the movement of many particles on the timber surface. This paper presents experimental testing results of post-tensioned CLT walls with a focus on capturing timber compressive behavior using PTT. The PTT measurements were able to better capture small base rotations which occurred at the onset of gap opening and capture unexpected phenomena in core-wall tests. The single wall test result herein presented indicates that while the MMBA could predict the moment rotation behavior with reasonable accuracy, the peak strain response was under predicted in the compression toe. Further detailed study is required to better understand the complex strain fields generated reflective of the inherent cross-thickness inhomogeneity and material variability of CLT.


The invention relates to a multilayered elastomer hose each having at least an inner layer, an outer layer and a reinforcing layer. In order to increase the carrying capacity of conventional elastomer hoses while maintaining the typical flexible structure further, the invention provides that the reinforcement layer contains a sulfur-containing polymeric material.


—Handling mobility at the transport layer is an in- teresting approach to attain seamless handover in the context of heterogeneous access networks. To support terminal mobility, an extension of SCTP called SCTP-DAR (SCTP Dynamic Address Reconfiguration) (a.k.a. mobile SCTP) has been defined allowing SCTP endpoints to update IP address and inform the remote peer about primary address change. However, mobile SCTP suffers from performance degradation during handover. In this paper, we investigate two handover-related issues: reduction of data rate immediately after handover and packet reordering. The first issue is caused by the congestion control mechanism, which forces the ongoing traffic to enter the slow-start phase when moving into the new path after handover. The second issue is caused by the asymmetric characteristics of access networks such as the different bandwidths and delays in heterogeneous access networks. In order to solve these issues, we propose to use a combination of two mechanisms, congestion control parameter update and buffer retransmission.


An optical instrument for in-vivo corneal autofluorescence measurements in the human eye is described. This instrument measures corneal autofluorescence without burden to the patient. The corneal tissues are excited tangentially by wavelengths in the spectral region of 450 to 500 nm and the fluorescence emitted by the corneal tissue passing through a suitable set of barrier filters is collected by a miniature photomultiplier. Autofluorescence data are recorded in sixteen measurement cycles during a period of 10 seconds and the average value has been considered. The instrument demonstrates good safety characteristics.


An overview is given of the material properties of exchange-biased spin-valves. More specifically, we discuss the microstructure and magnetic properties of these materials as relevant for (future) industrial application in magnetoresistive read heads for rigid disk and tape recording and Magnetic Random Access Memory (MRAM) devices.


OBJECTIVE To establish a selective and sensitive UPLC-MS/MS method for determination of Galanthamine hydrobromide in the dog plasma.METHODS BEH C18(50 mm×2.1 mm,1.7 μm)was used as the solid phase,the mobile phase consisted of acetonitrile-0.01 mol·L-1 ammonium acetate(contained 0.1% formic acid)(40:60).The flow rate was 0.1 mL·min-1,column temperature was 40 ℃,and inject volume was 3 μL.The monitoring ion of Galanthamine hydrobromide and internal standard clenbuterol hydrochloride was m/z 288.23→198.06,m/z 277.08→202.93,respectively.RESULTS A good linearity was shown in the range of 2.38-609.60 μg·L-1(r=0.998,n=5).The average recovery was 102.3% with intra-day RSD and inter-day RSD less than 15%.Plasma matrix had no effect on quantification of Galanthamine hydrobromide.CONCLUSION A simple,rapid,sensitive,selective and accurate UPLC-MS method was developed for the determination of Galanthamine hydrobromide in plasma.


Throughout the 2016 U.S. election and 2017 administration transition, there has been lively debate as to how U.S. trade policies might impact U.S. households and, particularly, workers. As consumers, households gain from trade liberalization as prices fall and real income rises. As workers, households gain from trade liberalization if sectoral expansion increases earnings. In the short-run households lose if sectoral contraction decreases workers' earnings. However, workers in contracting sectors shift to expanding sectors, minimizing household losses. A worker's ability to adjust depends on worker skill levels (Autor et al. 2013), timing, and locality (Caliendo et al. 2015).

In this paper, I analyze the distributional effects of trade across U.S. workers distinguished by occupation and sector in an expanded comparative static model of global supply chains, based on Walmsley et al. (2017). I use U.S. labor statistics for twenty-two occupations and fifty-seven sectors (Carrico and Tsigas 2014). I link this occupational database to a new multi-regional input-output (MRIO) database (Carrico 2017) with composite tariff rates differentiated between firms and consumers.

Incorporating this mapped occupational database into this new MRIO framework, I trace the effects of trade shocks and, in particular, changes in trade policy to households and workers. In terms of consumption, I demonstrate how changes in tariff rates affect imports demand for households relative to firms. In terms of earnings, I demonstrate how changes in tariff rates affect household earnings as sectoral expansion or contraction affects labor demand. Given the tariff escalation captured by the MRIO with differentiated tariffs, consumer response to trade shocks is greater than estimated under prior MRIO frameworks.


The feeding habit and nutrient level of six species of shrimps from Taiwan Strait and its adjacent sea areas were studied in this paper. The results show that they are crustacea of omnivorous. The main foods of Parapenaeposis harduicki,Trachypenaeus curvirostris and Metapenaeus joyneri are benthos-zooplanktons. For Solenocera crassicornis andMetapenaeposis barbata,the staple food is zooplanktons-benthos.Their nutrient levels are 1.64~2.21.The Metapenaeus joyneri,Parapenaeposis cornuta, Metapenaeposis barbata and Trachypenaeus curvirostris belong to omnivorous ofthe second nutrition layer. Solenocera crassicornis and Parapenaeposis harduickii belong to lower carnivores of the third nutrition layer. Their feeding niche breadth ranges are 1.24~6.48,in a size order from Parapenaeposis harduickii to Solenocera crassicornis, Trachypenaeus curvirostris,Metapenaeus joyneri,Metapenaeposis barbata, Parapenaeposis cornuta;The overlap index of diet among the six species of shrimps are 0.044~0.716.Except for Metapenaeus joyneri( 0.15),others overlap prominently,so they are in a fierce rivalry on diets resource,such as Copepoda,Macrura,young fish,Polychaeta,Bacillariophyta and Sarcomastigophora.


Purpose – The purpose of this paper is to report the formative evaluation results from the Association for Supervision and Curriculum Development Healthy School Communities (HSC) pilot project. Design/methodology/approach – This study utilized 11 HSC pilot sites in the USA (eight sites) and Canada (three sites). The evaluation question was "What are the levers of change in a school community that allow for the initiation and implementation of best practice and policy for improving school health?" Pre- and post-site visits along with in-depth interviews with school teams, teachers, students, administrators, community stakeholders and other involved individuals, school site report reviews, Healthy School Report Card results and school improvement plans were used for evaluation purposes. Findings – This study identified nine levers of change: principal as leader of the HSC efforts; active and engaged leadership; distributive team leadership; effective use of data for continuous school improvement; integratio...


Over the last decades there has been a growing interest in modeling human performance and analyzing human activity and human operator behavior to improve system design. A variety of tools and approaches which are based on task analysis methods and tools have been proposed. As technology advances and tasks become more demanding, human work changes increasing the need to create new methodologies and tools for task analysis to face the new challenges. The main aim of this research is to develop a new framework and model for simulation of human tasks performed by individuals with varying levels of skills, considering operator workload and human errors. In order to achieve this goal and fill the current gaps, a review of existing task analysis methods and tools is conducted and a model named UTASiMo is proposed. In addition, the Unified Modeling Language is used to describe the conceptual model and illustrate the different constructs and concepts included in the model. Finally, we present a case study and a preliminary simulation model designed in AnyLogicTM.


Foreign scholars believe that parole fluency of nonparent language can be improved and attained by learning phrases and idioms, and by practicing repetition. Obviously, these means are certainly of some help to the improvement of parole fluency but they have proved almost impossible to attain real fluency, because they have isolated the practice of essential factors for obtaining the fluency. Facts indicate that only when the exercise simultaneously include comprehensive elements for fluency acquisition, intensified teaching and "intensified pronounciation, meaning, symbol unity system" is added as a complementary part of our traditional teaching, can the acquisition be possible.


As the attracks from network inside is more than from network outside,network admission control technology become the precondition of network security.In this paper,we have reviewed the developments of methods of network admission control technology and the plan from main IT companys.We think network admission technology should adapt the different network enviromental,and realize the flexible policy in network admission control process.


appears, a matter of no great antiquity. So much for evidence that the tendency to decorate feet is as universal as it is ancient. Now again remember, I am not asking you to wear square-toed shoes, nor to discard high heels, nor to do anything except to seek out that last in which your individual feet find comfort and act well. The time when your feet and mine could have been made anatomically perfect is past. By proper orthopedic treatment they can be relieved of disabilities, but anatomically perfect they cannot ever become. Dr. Blodgett, an orthopedic surgeon of Boston, reported that among one thousand persons who had presented themselves with defective feet, all, or almost all, had been relieved of their disabilities and not in one instance had a defective foot been made into a normal foot. Distorted feet cannot be cured, they must be prevented. Ideally shoes should be made over individual lasts; this is however especially with growing children, not practicable. I have therefore selected several types of commercial shoe which have, in my experience, most often proved satisfactory. Frequently one has to take one of these shoes and modify it to meet the needs of the individual. This, like plate fitting, can of course only be done by one trained to the work. One of the most lucrative features of orthopedic practice is the correction of ailments which have been aggravated by shoe-store fitted plates. Little growing children should wear loose, nonshrinkable stockings and shoes made on the sandal type of last. I prefer low shoes to high, since the so-called "uppers" tend to check the up and down motions of the foot on the leg. That "uppers" support the ankle is a fallacy. An ankle which is so weak that it cannot be balanced and must be supported, 'calls for a bar up the side of the leg. The upper" merely conceals the distortion in these cases. It has not leverage enough to correct it. The proper shoe is that whose insole corresponds with the outline imprint on paper of the stockinged foot, but has a somewhat longer toe. Its inner border should be higher than its outer, just as the inner border of the foot.is higher than its outer border. The joints where side to side motions are made occur rather more than three-fifths of the way from the toe to the heel; therefore the shank of the shoe should be short. A long narrow shank would splint the foot and side to side motions would be impossible. The heel should be broad, advanced well under the instep, and high or low according to the character of the individual foot. Of course, in. the really normal foot no heel is needed; but we do not get really normal feet. This is neither the time nor the place for me to enter into an exhaustive discussion of defective feet. Here and now I can only tell you that every child who "toes in" is either wearing too short a shoe or is trying to save his arches by contracting the muscles at the inner sides of his feet; every child who "runs over" his or her shoes, who shifts from one foot to the other, who stands with the legs far apart, or with the knees locked, who persistently leans up against the furniture during recitation, who regularly walks with a shuffling, springless gait, consciously or unconsciously, is a sufferer from weak feet, and is in need of proper medical attention. Weak feet are not always manifested by symptoms directly referable to themselves. Lately I submitted to the Academy of Medicine a report on the following unusual cases: One patient, where the end of the back, the socalled os coccyx, had been removed for symptoms typical of disease of that region, "coccygodynia" it is called; One lady who had been subjected to capital operations for backache; One man suffering with painful knees; Two young women who had been supposed to have hip trouble; and Two men who were said to have disease of the spine. All of these patients were shown to have defective feet, and though the feet themselves had at no time presented subjective symptoms, treatment of this foot condition gave relief from the other and apparently dissociated symptoms. I merely cite these cases to show you how important a matter really is the hygiene of the feet. I think that on reflection my purpose in this paper will be apparent to you. The whole trend of modem thought is toward economy. .Economy of natural resources, economy of time, economy of 'labor. "Scientific Management" it has come to be called. Here I have attempted to show yoeu as briefly as might be, how scientific management applied to the employment of that most complex of all machines, the human body, and to suggest to you some of the kinds of ways in which its usefulness might be hampered by unscientific management. Against these you should unceasingly be upon your guard. To those who will apply the principles suggested, a new field of interesting spieculation and observation will open up. The study of eugenics is -as yet in its infancy. Many problems, which have not here been touched upon, will spring up to perplex you. But in seeking to solve them, you will yourselves attain to a higher 'intellectual level. Remember always that you are, yourself, not an imitator, but an original observer, and your own original recorded observations in this field of endeavor will add something to the sum of human -knpwledge, will accomplish somewhat to the uplift and betterment of the race. For to no one who seeks it -humbly is the truth ever wholly hid. 350 Post Street.


The historiography of the Communist Party of Great Britain (CPGB) has grown rapidly since its demise in 1991 and has created much debate for a Party seen as only of marginal interest during its actual existence. Since 1991, there have been four single volume histories of the Party, alongside the completion of the 'official' history published by Lawrence & Wishart and several other specialist studies, adding to a number of works that existed before the Party's collapse. In recent years, much of the debate on Communist Party historiography has centred on the Party and its relationship with the Soviet Union. This is an important area of research and debate as throughout the period from the Party's inception in 1920 to the dissolution of the Communist International (Comintern) in 1943 (and even beyond), the shadow of the Soviet Union stood over the CPGB. However an area that has been overlooked in comparison with the Party in the inter-war era is the transitional period when the CPGB went from being an influential part of the trade union movement to a Party that had been wrought by internal divisions, declining membership and a lowering industrial support base as well as threatened, alongside the entire left, by the election of Margaret Thatcher in 1979. This period of CPGB history, roughly from 1973 to 1979, was heavily influenced by the rise of Gramscism and Eurocommunism, in which a significant portion of the Party openly advocated reforms and a shift away from an emphasis of industrial militancy. It is a period that is important in CPGB historiography and has been overlooked in comparison with the lively debate seen over the CPGB's relationship with Moscow. The purpose of this article is to readdress the balance by examining what historians have written on the matter and how this fits into wider historiographical trends of the Party. The issue of the CPGB and its relationship with the Soviet Union has been a contentious one throughout the Party's history and indeed highly debated within its historiography. The spectre of the Soviet Union over the domestic affairs of the


This Letter presents the observation of the rare Z boson decay Z $\to\psi\ell^+\ell^-$. Here, $\psi$ represents contributions from direct J/$\psi$ and $\psi$(2S) $\to$ J/$\psi X$, $\ell^+\ell^-$ is a pair of electrons or muons, and the J/$\psi$ meson is detected via its decay to $\mu^+\mu^-$. The sample of proton-proton collision data, collected by the CMS experiment at the LHC at a center-of-mass energy of 13 TeV, corresponds to an integrated luminosity of 35.9 fb$^{;-1};$. The signal is observed with a significance in excess of 5 standard deviations. After subtraction of the $\psi$(2S) $\to$ J/$\psi X$ contribution, the ratio of the branching fraction of the exclusive decay Z $\to\psi\ell^+\ell^-$ to the decay Z $\to\mu^+\mu^-\mu^+\mu^-$ within a fiducial phase space is measured to be $\mathcal{;B};($Z $\to\psi\ell^+\ell^-) / \mathcal{;B};($Z $\to\mu^+\mu^-\mu^+\mu^-) =$ 0.67 $\pm$ 0.18 (stat) $\pm$ 0.05 (syst).


The Biot theory of wave propagation in porous, saturated materials contains 13 parameters. We discuss empirical and theoretical ways to predict values of these parameters for natural materials. The self‐consistent theory of composites is used to predict the elastic moduli of the skeletal frame assuming that the inclusions (pore fluid, sediment grains) are needle‐shaped at low concentrations. The Biot theory is then used to predict compressional and shear wave speeds in consolidated materials. In a man‐made material (porous sintered glass), the predictions agree with experimental data to within 3% (experimental uncertainty is also 3%); these samples were distilled‐water‐saturated. The predictions agree with data to within 1% for Berea sandstone, and to within 5% for Bedford limestone; all of these samples were brine‐saturated. The predictions agree with data to within 8% for distilled‐water‐saturated Bedford limestone. In the natural sedimentary rocks, the experimental uncertainty in measured wave speeds i...


The problems existing in die box and lubrication device of common dry wire drawing machine are: lubrication powder is easy to coke and leading to lubrication failure;the dry friction causes short service life for wire drawing die;and leading bad mechanical properties of steel wire and more consumption of die and lubrication powder.After the improvement of die box and lubrication device,lubrication powder can cycle flow in lubricant box,wire drawing die can rotate as working,cooling of wire drawing die is changed from open water cooling into seal pressure water cooling.Using improved device to produce diameter 5.05 mm steel wire,the bend value adds from 8 times to 12~15 times,elongation increases from 0.1%~0.5% to 1.5%~2.0%,consumption wire drawing die decreases from 0.25~0.35 pieces to 0.13~0.15 pieces,and lubricant powder consumption decreases from 0.7~1.0 kg to 0.4~0.7 kg,the electricity energy consumption decrea-ses from 230~250 kW·h to 180~190 kW.h per ton steel wire.The wire breaking numbers decrease from original 5~8 times to 0.5 times for producing 100 tons stranded steel wire.


A webquest is a collaborative research activity in which students obtain most of the information from the Internet. The article presents the steps to follow to make a webquest, the benefits of this tool for both students and teachers, and a series of links to find out more.


EPA denied a petition to delete Methyl Isobutyl Ketone from the list of chemicals subject to Toxics Release Inventory reporting requirements.


Administration of dietary antioxidants has been suggested to protect against liver tissue damage induced by radiation exposure. Silymarin is a polyphenolic plant flavonoid derived from Silymarin marianum that has hepatoprotective and anticarcinogenic effects. Therefore, the present study was carried out to investigate the radioprotective activity of Silymarin against radiation-induced liver damage. In this work, the total phenol content of silymarin was 0.527±0.016 mg GAE/ mg, total antioxidant capacity was 139±10.5 μmol/l and the DPPH radical scavenging activity was 1.52±0.12 mg/ml. The results showed that γrays (6 Gy) caused a significant increase in serum level of alanine and aspartate aminotransferase, alkaline phosphatase, gamma glutamyl transferase and the level of hepatic malondialdehyde and xanthine oxidase activity. Also, a significant decrease in hepatic glutathione level and xanthine dehydrogenase, superoxide dismutase and catalase activities was observed, compared with control group. Oral administration of silymarin extract prior radiation exposure was found to offer protection against all the radiation-induced biochemical alterations. These findings showed that silymarin is a powerful antioxidant herbal drug which can protect biological systems against the oxidative stress and tissue damage induced by radiation exposure.


This thesis aims at exploring the space that remained free from the "Marxist cultural hegemony" in the post -war Italian intellectual milieu and focuses on Elemire Zolla, an eccentric writer whose impressive body of work remained far from the mainstream.
Although he wasn't a political author in the strict sense, his overall thought has a broad political meaning in the noblest sense of the word and covers a wide range of subjects.
The research has been carried out intertwining history of intellectuals and political history through qualitative research methods, studying primary and secondary sources and also using the tool of interview.
Zolla emerges as a prominent anti-modern writer who managed to preserve his intellectual freedom within the highly ideologized Italian intellectual milieu.
His thought - focused on the idea of a perennial Tradition – shows internal coherence and appears convincing


Abstract Events, like objects, can be decomposed into parts. Path, the spatiotemporal trajectory of an object during an event, is the most commonly labeled event feature across the world's languages, provides important social information, and is increasingly central to theories of general event segmentation. However, little is understood about how adults visually segment paths. We apply theories developed for object segmentation to help understand path segmentation. Overall subjects segmented equivalent object shapes and event paths in similar ways following patterns predicted by Singh and Hoffman's (2001) geometric analysis of object parts. There were two notable differences between object and event segmentation: (1) event parsing occurred at points of negative curvature minima and positive curvature maxima as opposed to simply negative curvature minima; and (2) event parsing was more frequent and variable than object parsing. Implications of these results for event perception and categorization are discussed.


This paper studies a new alteration of Yosida algebraic splitting methods for the Navier--Stokes equations. By applying the usual or pressure-corrected Yosida splitting techniques to discretizations written in terms of velocity and pressure updates $(u^{n+1}-u^n,p^{n+1}-p^n)$, we show that the accuracy is increased by one full order in $\Delta t$ without any additional cost in the respective methods. Proofs of the convergence results are given both in linear algebraic and finite element frameworks. Several numerical tests are given which reveal the (sometimes dramatic) improvement in accuracy offered by the proposed fix.


INTRODucTION Chronic obstructive pulmonary disease or COPD, a chronic inflammatory airway disease, is one of the top 10 causes of mortality and reason for hospitalisation in Singapore. Apart from asthma, COPD is the second most common chronic respiratory disease being managed in primary care and is set to increase in prevalence due to the aging population in the local community. The Ministry of Health of Singapore has published clinical practice guidelines in 2006 to support respiratory and family physicians in providing optimal care for this group of patients based on clinical evidences. With growing amount of data and literature from research carried out globally, we examined the issues and use of evidence-based practice in managing three COPD patients with varying needs, in a local primary care centre.


The study of energy harvesting by means of vortex induced vibration systems has been initiated a few years ago and it is considered to be potential as a low water current energy source. The energy harvester is realized by exposing an elastically supported blunt structure under water flow. However, it is realized that the system will only perform at a limited operating range (water flow) that is attributed to the resonance phenomenon that occurs only at a frequency that corresponds to the fluid flow. An introduction of nonlinear elements seems to be a prominent solution to overcome the problem. Among many nonlinear elements, a bistable spring is known to be able to improve the harvested power by a vortex induced vibrations (VIV) based energy converter at the low velocity water flows. However, it is also observed that chaotic vibrations will occur at different operating ranges that will erratically diminish the harvested power and cause a difficulty in controlling the system that is due to the unpredictability in motions of the VIV structure. In order to design a bistable VIV energy converter with improved harvested power and minimum negative effect of chaotic vibrations, the bifurcation map of the system for varying governing parameters is highly on demand. In this study, chaotic vibrations of a VIV energy converter enhanced by a bistable stiffness element are quantified in a wide range of the governing parameters, i.e. damping and bistable gap. Chaotic vibrations of the bistable VIV energy converter are simulated by utilization of a wake oscillator model and quantified based on the calculation of the Lyapunov exponent. Ultimately, a series of experiments of the system in a water tunnel, facilitated by a computerbased force-feedback testing platform, is carried out to validate the existence of chaotic responses. The main challenge in dealing with experimental data is in distinguishing chaotic response from noise-contaminated periodic responses as noise will smear out the regularity of periodic responses. For this purpose, a surrogate data test is used in order to check the hypotheses for the presence of chaotic behavior. The analyses from the experimental results support the hypothesis from simulation that chaotic response is likely occur on the real system.


This study investigates students' work on analyzing a literary text, a cartoon strip, with focus on their use of instructional, analytical concepts. Excerpts from a group conversation and from individually written texts are analyzed from a sociocultural, dialogical perspective. The analysis of the conversation shows how such concepts help the students to study the text more closely and maintain an analytical focus. The use of concepts thus helps the students understand the text and what text analysis is about. The students' written texts show that they build on the understanding developed in the group discussion. The analytical focus in the discussion helps them maintain the understanding developed in group when they write individually. Thus, the use of analytical concepts contributes to mediating between group reasoning and individual writing.


Objectives: To identify factors associated with failure of noninvasive ventilation (NIV) in the post-extubation period. Data Sources: We searched Embase Classic +, MEDLINE, and the Cochrane Database of Systematic Reviews from inception to February 28, 2022. Study Selection: We included English language studies that provided predictors of post-extubation NIV failure necessitating reintubation. Data Extraction: Two authors conducted data abstraction and risk-of-bias assessments independently. We used a random-effects model to pool binary and continuous data and summarized estimates of effect using odds ratios (ORs) mean difference (MD), respectively. We used the Quality in Prognosis Studies tool to assess risk of bias and the Grading of Recommendations, Assessment, Development and Evaluations to assess certainty. Data Synthesis: We included 25 studies (n = 2,327). Illness-related factors associated with increased odds of post-extubation NIV failure were higher critical illness severity (OR, 3.56; 95% CI, 1.96–6.45; high certainty) and a diagnosis of pneumonia (OR, 6.16; 95% CI, 2.59–14.66; moderate certainty). Clinical and biochemical factors associated with moderate certainty of increased risk of NIV failure post-extubation include higher respiratory rate (MD, 1.54; 95% CI, 0.61–2.47), higher heart rate (MD, 4.46; 95% CI, 1.67–7.25), lower Pao2:Fio2 (MD, –30.78; 95% CI, –50.02 to –11.54) 1-hour after NIV initiation, and higher rapid shallow breathing index (MD, 15.21; 95% CI, 12.04–18.38) prior to NIV start. Elevated body mass index was the only patient-related factor that may be associated with a protective effect (OR, 0.21; 95% CI, 0.09–0.52; moderate certainty) on post-extubation NIV failure. Conclusions: We identified several prognostic factors before and 1 hour after NIV initiation associated with increased risk of NIV failure in the post-extubation period. Well-designed prospective studies are required to confirm the prognostic importance of these factors to help further guide clinical decision-making.


ABSTRACT This article presents a novel compact folded Zeroth-Order Resonant (ZOR) antenna using concept of Composite Right/Left-Handed (CRLH) transmission line operating in the WLAN/ISM bands of 2.4 and 5.2 GHz for Internet of Things (IoT) applications including USB dongle and radio-frequency identification (RFID) systems. It consists of two-unit cells of a CRLH transmission line and operates in a series resonant mode with an overall size of 1.6 mm × 38 mm × 9 mm. The measured results show that fractional bandwidths of 11.34% and 3.9% for S11 < −10 dB, and radiation efficiencies of 64.89% at 2.4 GHz and 78.88% at 5.2 GHz are obtained. A comparison between our proposed work and other existing works shows the achievement of considerable antenna miniaturization using the technique of CLRH transmission line. The measured and simulated results are generally in good consensus. Being novel and compact, the proposed design is a potential candidate for diverse IoT devices including USB dongles and low-profile RFID tags.


As for the internal ordering of particular Churches, the actual Code of Canon Law mentions a few collegial organs, which assist in managing the diocese (cann. 460–514). The object of this paper is not to analyze all the auxiliary collegial organs mentioned by the Code, but to consider only those organs, which are councils – the councils, which support the diocesan bishop. Such councils are: the finance council; the episcopal council; the presbyteral council; the mission council and the college of consultors; the pastoral council – all of them support the bishop, especially in the pastoral service as well as in managing the spiritual and temporal goods of the diocese. The diocesan bishop, apart from these "canonical" councils, can also institute in his diocese other councils, which are not in the Code, for example: the decanal council, the religious council, the council concerning young people, the catechetical etc. All these serve as consultative organs of the bishop. Their opinions, advices or proposals should support the diocesan bishop and assist him in managing his diocese in a proper way.


The urea denatured recombinant human granulocyte colony-stimulating factor (rhGCSF) which was expressed in Escheriachia coli (E. coli) was refolded with simultaneous purification by strong anion exchange chromatography (SAX) in the presence of low concentration of urea. The effect of urea concentration on this refolding process was investigated. The obtained refolded rhG-CSF has a high specific activity of 2.3×108 U/mg, demonstrating that the proteins were completely refolded during the chromatographic process. With only one step by SAX in 40 min, purity and mass recovery of the refolded and purified rhG-CSF were 97% and43%, respectively.


The capillary stress mechanism and plastic settlement mechanism of the formation of plastic shrin-kage cracking are presented,and the research progress about the influence factors of plastic shrinkage cracking is summarized.Finally,it emphasizes the preventive measures against the plastic cracking from the viewpoint of concrete mix,pouring,and curing.


This paper provides insight into the issue of opium trafficking in Afghanistan. In 2014, despite U.S., Afghan, and international efforts since 2001, poppy-opium cultivation in Afghanistan reached an all-time high. The Afghan opium trafficking industry provides funding to terrorist groups and transnational crime organizations and is responsible for the continued corruption of government officials, police officers, and intelligence agents in Afghanistan, Pakistan, Iran, and other nations. Aside from increased corruption and funding of terrorists and criminals, the opium trade creates opium and heroin addicts out of men, women, and children across the globe. The history of how the opium problem reached its current state and an account of the methods previously attempted to combat the opium trade in Afghanistan is included in the paper. By looking at the past, the reader will gain an understanding of the level of success law enforcement efforts have achieved as compared to reliance on other approaches such as crop eradication, and alternative livelihood assistance. Acknowledging that this issue negatively affects many countries, I argue for the international community to cross current alliances and create and deploy a unified law enforcement counternarcotics force to work with Afghanistan, Pakistan, Iran, and surrounding nations to target the problem at the point of supply. This paper relies on information gathered from a variety of sources to provide a broad scope of perspectives including reports from the United Nations, the United States Government as well as books and articles from social scientists, journalists, and DEA agents.


We performed a mass treatment of anchylostomiasis for the inhabitants of four rural villages and for the pupils of two lower-secondary schools in Ichihara-gun, Chiba Prefecture, and obtained the following results:1. Evaluation of the effect was made 3-4 weeks after the treatment by salt flotation method (plus zinc sulfate) and also by culture. For the salt flotation method two specimens were prepared for each subject. Follow-up examinations were made at regular intervals by the said two methods, and the results were corrected accordingly.2. Percentages of conversion to negative (i. e. disappearance of both larvae and ova from stool specimens) by different anthelmintics were approximately: 43.5% for tetrachlorethylene, 41.0% for 1-brom naphtol (2), 38.2% for ascaridol-tetrachlorethylene compoundno significant difference was observed among these three drugs; while 14.8% for the compound preparation of ascaridol-tetrachlorethylene-carbonum tetrachloratum and 4.8% for oil of chenopodium. All of these anthelmintics were found more effective for Necator americanus than for Anchylostoma duodenale. And the percentages of conversion to negative were in reverse proportion to the number of worms discharged. Even with the same kind of anthelmintic, percentages of conversion to negative differed with areas where it was administered. Percentages seemed lower in the severely infected villages.Percentage of cenversion to negative by 1-brom·Enaphtol (2) was lower with smaller doses than with the standard dose for adults (4g.per diem for two consecutive days). There was significant difference between them.In the mass treatment with tetrachlorethylene, both the percentage of conversion to negative and the appearance of secondary effects were about the same with the group dosed together with laxativa and with the group dosed without it.3. Delayed effect (i. e. conversion to negative observed by follow-up examinations subsequent to the anthelmintic treatment) occurred to 10.8-17.6% of the cases treated with tetrachlorethylene, to 3.0-11.1% of those treated with 1-brom·Enaphtol (2), and to 14.6%-24.1% of those treated with ascaridol-tetrachlorethylene compound. 78% of such delayed conversion was observed during the four months and 93% during the six months succeeding the treatment. Development of the delayed effect was grasped by monthly counting of ova in stool specimens. The number of ova discharged (E. P. G.& L. P. G.) decreased to half the previous number at each consecutive examination, after the treatment, and in a manner of geometric progress gradually reached zero.


Crystal structures of multiple molybdenum enzymes clearly demonstrate interesting structural distortions involving the pyranopterin dithiolene. These distortions can be correlated with pyranopterin oxidation state through the use of DFT geometry optimized structures of the possible oxidation states, and these are correlated with enzyme family. The potential role of the pyranopterin dithiolene in electron transfer in the varied enzyme familes has been explored through the use of non-equilibrium Green's function (NEGF) electron transport calculations. These calculations demonstrate clear differences in electron transport behavior as a function of pyranopterin oxidation state. The Jahn-Teller effect can strongly impact the geometric and electronic structures of molecules which are Jahn-Teller or pseudo-Jahn-Teller active. An intriguing JahnTeller effect has been explored in Cp2M(bdt) model compounds, which are shown to be useful models for studying pseudo Jahn-Teller effects in metal dithiolenes and


Energy resources in China are in short suplly,their consumption increases step by step,the use efficiency of energy is low.These factors make social and economic development in China faced with severe situation. For these reasons it is necessary to implement energy development strategy "Economization at First" for building a well-off society in an all-round way.In order to realize this strategy we should take next measures: drive saving on energy strictly according to the law,improve system and mechanism of save on energy,form new model industry system of save on energy,build up technologic supporting system of save on energy,devote major efforts to create a favourable social atmosphere for save on energy.


Accurate and rapid observation of sea surface wind is important for the research of ocean dynamic prediction model, offshore wind resource assessment, air-sea interaction and flux. A compact floating coherent Doppler lidar system named WindMast 350-M was developed by Ocean University of China (OUC) and Leice Transient Technology Co. LTD (LEICE) for the observations of sea surface wind profiles. As an observation device installed on buoy platforms, the first vehicular motion experiment was conducted at Laoshan campus of Ocean University of China(120.49°E , 36.16°N) on 06 and 12 March, 2019. During the first experiment, the wind profiles measured by the WindMast 350-M were compared with the results from a well calibrated Ground-based Coherent Doppler lidar WindMast WP350. In this contribution, the systematic design and the specifications of 350-M are presented in detail. The preliminary results of the vehicular motion experiment are discussed as well.


The Scalable HeterOgeneous Computing (SHOC) benchmark suite was released in 2010 as a tool to evaluate the stability and performance of emerging heterogeneous architectures and to compare different programming models for compute devices used in those architectures. Since then, high-performance computing (HPC) system architectures have increasingly incorporated both discrete and fused multi-core and many-core processors. The TOP500 list illustrates this trend: heterogeneous systems grew from a 3.4% to 18.0% share of the list between June 2010 and June 2015. Not only are there more heterogeneous systems on the TOP500 list today, those machines are responsible for a disproportionately large percentage of list's aggregate performance: as of June 2015, the performance share for heterogeneous systems has grown to 33.7%.
 Part of this shift toward heterogeneous architectures has stemmed from new products in the hardware accelerator market, such as Intel's Xeon Phi coprocessor, and improvements in the approaches for programming such accelerators. Existing approaches such as CUDA and OpenCL have become more powerful and easy to use, and directive-based programming models such as OpenACC, OpenMP 4.0, and Intel's Language Extensions for Offload (LEO) are rapidly gaining user acceptance. The benefits of these hardware and software advances are not limited to HPC; other problem domains such as "big data" are reaping the rewards also.
 The original SHOC benchmarks had adequate support for CUDA and OpenCL for graphics processing units, but did not support more recent programming models and devices. We extended SHOC to support evaluation of recent heterogeneous architectures and programming models such as OpenACC and LEO, and we added new benchmarks to increase SHOC's application domain coverage. In this paper, we describe our modifications to the stock SHOC distribution and present several examples of using our augmented version of SHOC for evaluation of recent heterogeneous architectures and programming models.


Formulae for estimating Stark widths of neural atomic lines with the G.B.K.O1 semiclasica theory is modified using a Coulomb cutoff field. The dipolar width function A2(z) is generalized to a correlated dipolar width function AC(z).


ABSTRACT Hyphomicrobium nitrativorans strain NL23 has been isolated from the biofilm of a denitrification system treating seawater. This strain has the capacity to denitrify using methanol as a carbon source. Here, we report the complete genome sequence of this strain in an effort to increase understanding of the function of this bacterium within the biofilm.


Determination of13CO2enrichment on the CO2 released from blood by acid has been used in situations in which breath sampling is difficult. This method can be improved by measuring this enrichment on the CO2 spontaneously released from blood. Therefore, simultaneous comparisons of13CO2content between breath and arterialized blood added with or without acid were performed in 51 samples from human studies, using the statistical method of Bland and Altman (J. M. Bland and D. G. Altman. Lancet 1: 307-310, 1986). Strong relationships exist between the methods ( r > 0.99) expressed in atom percent excess (APE). Compared with breath, the acid method overestimates the13CO2enrichment (0.318 ± 0.632 APE × 1,000, P < 0.001). The acid-free method shows similar enrichments to breath (0.003 ± 0.522 APE × 1,000, P = 0.97) with good precision and degree of agreement (95% confidence interval 0.15 APE × 1,000). The analysis can be performed up to 5 days after sampling with a good reproducibility. In conclusion, measuring13CO2enrichments on the CO2spontaneously released from blood is feasible, gives identical results to the breath method, and lessens operator manipulations. It allows study of situations in which the breath sampling method is not feasible.


Synthesis, Vibrational Spectra, and Crystal Structures of the Nitrato Argentates (Ph4P)[Ag(NO3)2(CH3CN)]·CH3CN and (Ph4P)[Ag2(NO3)3]

Tetraphenylphosphonium bromide reacts in acetonitril suspension with excess silver nitrate to give (Ph4P)[Ag(NO3)2(CH3CN)]·CH3CN (1), whereas (Ph4P)[Ag2(NO3)3] (2) is obtained in a long-time reaction from (Ph4P)Br and excess AgNO3 in dichloromethane suspension. Both complexes were characterized by vibrational spectroscopy (IR, Raman) and by single crystal structure determinations.

1: Space group P21/c, Z = 4, lattice dimensions at 193 K: a = 1781.5(3), b = 724.8(1), c = 2224.2(3) pm, β = 96.83(1)°, R1 = 0.0348. 1 contains isolated complex units [Ag(NO3)2(CH3CN)]−, in which the silver atom is coordinated by the chelating nitrate groups and by the nitrogen atom of the solvated CH3CN molecule with a short Ag—N distance of 220.7(4) pm.

2: Space group I2, Z = 4, lattice dimensions at 193 K: a = 1753.4(4), b = 701.7(1), c = 2105.5(4) pm, R1 = 0.072. In the polymeric anions [Ag2(NO3)3]− each silver atom is coordinated in a chelating manner by one nitrate group and by two oxygen atoms of two bridging nitrate ions. In addition, each silver atom forms a weak π-bonding contact with a phenyl group of the (Ph4P)+ ions with shortest Ag···C separations of 266 and 299 pm, respectively, indicating a (4+1) coordination of silver atoms.


The present review focuses on some major researches dealing with controlling Cowpea seed bruchid (CSB) due to Callosobruchus maculatus (Fab.) [Coleoptera: Bruchidae] by using some plant products. The objective of this review is to look in to the successes of the use of plant materials in the management of CSB especially in the tropics where bulk of the crop is cultivated and consumed. The review of available literature showed that, plants such as Neem, Azadirachta indica A. Juss; Garlic, Allium sativum (L.); West African pepper, Piper guineense Schumach; drum stick, Moringa oleifera Lam; African Basil, Ocimum gratissimum (L.); Moss plant; Barbula indica and Clausena anisata (Willd.) Hook has been used in CSB control. Available literatures showed that garlic, chilies and peppermint applied at the rate of 0.035–0.55g significantly (p?0.05) reduced oviposition, respectively compared to the control. Similarly, powdered flowers of M. oleifera applied at the rate of 0.5 g per 30 g of seeds caused mortality of CSB better than the control 8 hours after infestation. The use of C. anisata and Permethrin showed percentage mortality of cowpea bruchids was high using Permethrin but was not significantly (p?0.05) better than Clausena leaf powder. Groundnut oil applied at ? 4mls kg-1 does not affect germination process of cowpea stored for up to 12 weeks. However, increasing rate of application decreases germination. The review clearly indicated that plant products have potentials of controlling CSB in stored cowpea as they are safe and free from residue. They are hereby encouraged.


We present a model for coupled-resonator optical waveguide (CROW). A variation-aware Compact model provides CROW component S-parameters under varying spatial design perturbations, allowing efficient Monte-Carlo simulations and yield prediction.


This paper highlights specific actions the federal government can take to provide a strategic coordination function among the diverse set of actors with flexible, mission-interested capital, and to catalyze investment in energy innovation and deployment. Our primary goal is to advance a conversation among government stakeholders that will lead imminently to action, putting energy at the center of the burgeoning impact investing movement.


The benign hyperplasia of a prostate gland (BHPG) is one of the most actual problems of the modern urology. Objective of this research was the study of therapeutic pathomorphosis of BHPG and BHPG with PIN (prostatic intraepithelial neoplasia) at the administration of inhibitor 5α-reductase of I and II types (Avodart) by means of clinical, laboratory, instrumental and morphological methods. It was determined, that 89% of patients noted the partial improvement on the background of treatment. According to transrectal ultrasound study the volume of residual urine decreased by 49,5%, and prostate gland volume by 15%. During the morphological and morphometric research in the group of patients with BHPG and PIN in 72% of cases the transition to BHPG (clustered-villous and cribriform structures of epithelium decreased or disappeared, the quantity of hyperchromic nuclei and their size decreased) was observed. By means of immunohistochemical methods with markers PCNA and P53 the decrease of proliferative and increase of the apoptatic activity of the epithelium of glands was determined. Thus, Avodart is almost completely blocking the action of dihydrotestosterone, which is playing a major role in the development of BHPG. Statistically significant change of indices was observed at Avodart administration for more than 2 months.


1. In the pistillate flower of Myristica fragrans Von Houtt. the stele of the pedicel, after giving rise to the vascular traces to the bracteoles and perianth, continues into the gynophore and then into the wall of the gynoecium, where it gives rise to branches both to the periphery and, at a higher level, to the center. 2. The bundles of the inner ring bend downward, and some of them fuse to form the vascular supply to the ovule. 3. No distinct dorsal and ventral bundles are recognizable. 4. There is no evidence for regarding the gynoecium as bicarpellary.


The state of Hawaii is facing a critical shortage of affordable housing. The Hawaii Public Housing Authority is in the unique position to contribute to solutions both through new mixed- use, economically-diverse, TOD-oriented projects and through redevelopment projects. This paper presents the design of a community engagement process developed to involve future residents in the early phases of the design process of future housing. A series of co-creation tools and a mobile research lab ask the community how they would design more walkable, sustainable, and equitable communities, neighborhoods, and homes across Hawaii.


BALB/c mice were immunized with recombinant human cardiac troponin I(cTnI),and hybridoma cell lines secreting monoclonal antibodies(mAbs) against cTnI were screened after fusion of mouse splenic cell with Sp2/0 cells by ELISA.Cloning were performed by limiting dilution.In this way,12 positive hybridomas were obtained from 2 separate fusions,and the titers in ELISA assay of ascitic fluids and affinity constants were above 1∶1×105 and 1×108L/mol respectively.All these mAbs reacted well with cTnI from human heart tissue.And no cross-reaction could be found of each mAbs with cTnT、TnC、skTnI and skTnT.Three mAbs appeared to form a sandwich with cTnI.The successful establishment of mAbs anginst cTnI may be useful in the development of detection assay.


Financial market creates a complex and ever changing environment in which population of investors are competing for profit. Predicting the future for financial gain is a difficult and challenging task, however at the same time it is a profitable activity. Hence, the ability to obtain the highly efficient financial model has become increasingly important in the competitive world. To cope with this, we consider functional link artificial neural networks (FLANNs) trained by particle swarm optimization (PSO) for stock index prediction (PSO-FLANN). Our strong experimental conviction confirms that the performance of PSO tuned FLANN model for the case of lower number of ahead prediction task is promising. In most cases LMS updated algorithm based FLANN model proved to be as good as or better than the RLS updated algorithm based FLANN but at the same time RLS updated FLANN model for the prediction of stock index system cannot be ignored.


Objective:To study the curative effect of the visitation in therapy of the chronic schizophrenia.Methods:60 chronic schizophrenia were divided into two teams-the visitation team and the contrast team.The visitation team was treated for twelve weeks.Use the Positive and Negative Syndrome Scale(PANSS)、the Brief Psychiatric Rating Scale(BPRS) 、Scale for Assessment of Negative Symptoms(SANS) 、the Rate of recurrence 、the Activity of Daily Living Scale(ADL) 、the Scale for self-complied Medication comliance to assess.Results: There were some remarkable disitinctions between the remedial front and the back of the visitation team,in the general scores of BPRS and SANS and ADL,in the integration of SANS(P≤0.05).There was no remarkable distinctions in the general scores of Medication compliance and the rate of recurrence(P0.05).There were some remarkable distinctions between the visitation team and the contrast team,in the general scores of BPRS and SANS and ADL,in the integration of SANS(P≤0.05).Conclusions: The curative of the visitation redounds to ameliorate the chronic schizophrenics` symptom,especially to the negative symptom,and improve the life quality and the society ablity.


According to the requirement of equipment data acquisition of semiconductor manufacturing equipment in the factory automation, this paper presents a new method to acquire the equipment data, which is based on the SEMI Interface A for data collection management. The method defines how to collect the information which we need through the use of a named data collection plan. The testing results show that the method meets the requirement of equipment data acquisition in the factory automation.


The article presents the control techniques of heavy metal pollution in vegetables as follows: bio-remediation,agronomic regulation,leaf surface control,and the research direction of the control techniques of heavy metal pollution in vegetables.The purpose of this paper is to provide references for the control of heavy metal pollution in vegetables.


Key Points Within homogeneous ELN risk categories, different postremission approaches (auto-SCT vs allo-SCT) result in different outcomes. Measurable residual disease confirms its role as a driver of transplant allocation for patients placed in the ELN2017-IR category.


Wetlands are ecologically important and productive environments which help in several global processes. Microplastic pollution is an environmental issue of great concern. The studies related to this issue have been reported chiefly on the marine environment whereas freshwater ecosystems especially wetlands are receiving less consideration. Harike wetland is a northern largest wetland of India with area at present of 86km2. It is home to several migratory birds along with being rich in fish diversity. In this study the presence and type of microplastic in surface water of Harike wetland were investigated. Two types of microplastic are found in harike wetland namely nylon (Nylon 6) and high density polyethylene with size ranging from 4mm to 60μm. Results from the FTIR, RAMAN and GC-MS confirmed the presence of microplastic in Harike wetland. Rivers Sutlej and Beas could be a source of sewage input towards Harike wetland thereby being the reason of microplastic contamination in it. This study insights better understanding of microplastic pollution in wetlands giving way towards the threat that microplastic transfer could cause through the food chain and affect other organisms. CONTACT Rahul Singh email@example.com Department Of zoology, School of bioengineering and biosciences, Lovely Professional university, Phagwara, Punjab, India. © 2021 The Author(s). Published by Enviro Research Publishers. This is an Open Access article licensed under a Creative Commons license: Attribution 4.0 International (CC-BY). Doi: http://dx.doi.org/10.12944/CWE.16.1.12 Article History Received: 21 June 2020 Accepted: 02 March 2021


Abstract The analysis of certain parameters related to cognitive and to motor humans' activities in everyday life conditions can allow to detect potential behavioral troubles, make diagnoses and assess patients' progress after a therapy. Within this context, personal robots can provide an autonomous movable platform for embedded sensors allowing to detect and track humans while ensuring an optimal observability of the person's activity in complex and cluttered environments. This paper presents a framework combining a multimodal human detector based on sensors embedded in a mobile robot and a decisional engine exploiting the fuzzy logic mechanisms to make the robot track humans, maximizing observability and facing losses of detection. The robustness of this framework is evaluated experimentally in home spaces through different scenarios. Such a mobile system provides an effective marker-less motion capture means for sensing human activity in non-invasive fashion. We present a physical model based method exploiting the features of the system and of the embedded Kinect. Its performances are evaluated first comparing the results to those obtained with a precise 3D motion capture marker based system and to data obtained from a dynamic posturography platform. Then an experiment in real life conditions is performed to assess the system sensitivity to some gait disturbances.


Accurate diagnosis of head lice is crucial to the effective management of pediculosis capitis. Joanna Ibarra looks at screening methods and the importance of the whole-school approach.


As we approach another presidential election in America, it seems the chasm that separates the beliefs and attitudes between groups of people is deeper and wider than ever. The emotions and convictions are just as fervent on both sides of various issues, with speakers expressing their opinions with the zeal of religious conviction. A p p a r e n t l y n o reconciliation is possible. Consider the debate over abortion. A couple of years ago the Supreme Court decided a case that gave some modest hope to those who would limit abortions. A Justice writing the minority (opposing) opinion on the case said "a chill wind is blowing in America." With, at that time, over 25 million abortions having already happened, and the prospect of millions more to come, the ominous cloud this man saw on the horizon was that there might be a slight slowdown in the constant flow of abortions on demand. Abortion rights speakers warn of the horrible injustice that is facing us if any legal impediments are placed in the way of the continued destruction of unborn babies. Simultaneously, some who oppose abortions are willing to risk prison to save just one baby from the abortionist. Emotional speeches at political conventions rally the party faithful in the continued fight to stop abortion. Both sides show religious zeal; both sides see themselves as defenders of justice. Both sides know that there is no middle ground. Other issues ignite similar emotional fires. The battle concerning the legitimacy of homosexuality is another prime example. It is a hot issue in politics this year. Another issue that is simmering, sure to get hotter, is animal rights. The use of a baboon's liver to save the life of a human aroused demonstrators; they were incensed at the injustice done to the baboon. It has gotten so strange that it would not seem incongruous if two sides of the same placard read, "Save the whales; Kill the babies." Christian young people attending public school are bombarded with relentless absurdities (to


A novel, efficient and eco-friendly method is described for the synthesis of alkyl thiocyanates from alkyl halides. The reaction was carried out by treatment of various alkyl halides with ammonium thiocyanate in polyethylene glycol as reaction media. This procedure afforded the corresponding alkyl thiocyanates in high yields without formation of isothiocyanates as by-products.


The aim of this paper is to present an overview of the research concerning human response to vibration conducted in the EU FP7 CargoVibes project. The European Union-funded project CargoVibes involved 10 partners from 8 nations and ran from April 2011 to April 2014. The project was concerned with railway-induced ground-borne vibration affecting residents close to freight lines, with one work package that investigated human response to vibration, including sleep disturbance, community annoyance and the production of a best practice guide for evaluating response. Laboratory trials at the University of Gothenburg were used to measure the effects of vibration on sleep. Physiological and psychological impacts of vibration exposure were found. TNO led a meta-analysis (N = 4129) to determine exposure–response relationships for railway vibration, with existing data for community response supplemented with field studies in the Netherlands and Poland. The University of Salford led production of a guidance document that presents the state of the art regarding vibration measurement and assessment. Specific topics in the guide include human perception, evaluation methods, annoyance, sleep impacts and non-exposure factors. The outcomes presented in this paper represent a significant advance in the understanding of the human response to railway vibration and a step towards much needed harmonization of assessment methods.


Background The osteoarthritis is one of the most frequent consultations in primary medical care. The prevalence is between 6, 2 % and 26, 1 %. This is more frequent in women than in men. The results are similar to those of Europe, where people older than 75, the prevalence in women is double than in men. Objectives To know the prevalence of osteoarthritis in the different locations in our patients, the different treatment that this patient's use, how much pain they refer and the health education they have. Methods Design This is a transversal descriptive study in a basic urban area of health (19.658 persons > 14 years, 16.2% > 75 years. Population Randomization 450 osteoarthritis patients from 2514 patients with this diagnostic. Review the clinic histories and after that we interview the patients in the consultation or by telephone (patients or patients' family) Variables Age, sex, localization, overweight, drug treatment (analgesic, AINEs, Sysadoas, capsaicin, IBP/antagonists H2), slim if overweight, Physical exercise (walking > 30 minutes 3 days/week). Physical measures, prosthesis, orthoses, rehabilitation, balneareoteraphy, alternative therapy, health education, how much pain (pain descriptive verbal scale). Results We interview 406 patients (80,5%) 243 in the consulting room. Middle age 71 yeras (15,2), woman 73,6%. They describe the pain like moderate 30,4% and much several pain 26%. 81.9% the patient's used≥1 drug, and 2 drugs 42%. The 60.9% have drug when they have pain, the 18.1% have drugs all time (>3 month). Overweight 42,8%. Only 8,7% have normalized the weight. The 65% said that they know their illness and the 73% said that their the doctors has given their recommendation about doing exercise and losing weight Conclusions The localization more frequent is the knees, the most patients needs drugs. Only 25% are in the ideal weight but a few patients are slimming. References Carmona L, Ballina J, Gabriel R, Laffon A, EPISER Study Group. The burden of musculoskeletal diseases in the general population of Spain: results from a national survey. Ann Rheum Dis. 2001; 60:1040-5. Medline Hunsche E, Chancellor JV, Bruce N. The burden of arthritis and nonsteroidal anti-inflammatory treatment. A European literature review. Pharmacoeconomics. 2001; 19(Suppl 1):1-15. Medline Disclosure of Interest None Declared


Repeatability of network experiments has long been a goal for networking researchers but the lack of a scientific process of experimentation has made this exercise difficult to achieve. In this paper, we demonstrate that, if conducted in a scientific manner, experiments can indeed be repeated in different networks to produce the same results. We ran experiments in our lab, and on two different network configurations in ProtoGENI and demonstrated that we get similar results for network and application performance evaluations. We believe that this is an important step as we take the process of measurement-based networking research from its ad hoc phase into the realm of a scientific process. We also present these experiments using GENI infrastructure as a demonstration for other experimenters to run similar realistic experiments on GENI testbeds. Furthermore, we believe this is the first set of experiments to emulate per-connection Round- Trip-Times in GENI-based experiments.


OBJECTIVE To directly detect HBV genomic DNA extracted from clinical samples with peptide nucleic acid (PNA) biosensor. METHODS Extracted genomic DNA from 63 clinical positive samples caught from hepatitis patients and 15 negative sera samples were detected with PNA biosensor and quantitative PCR, respectively. The advantages and disadvantages of both methods were summarized and the detection limit of sensor method was finally determined. RESULTS Sixty samples were positive among 63 clinical cases with hepatitis detected by PNA biosensor, and positive rate hence was 95.24%. While 63 clinical cases were all positive using quantitative PCR. And 15 negative clinical cases were all undetected by both two methods. Detection limit of biosensor was 8.6 pg/L. No significant difference existed between two methods according to statistic analysis, but less time was used and no probe should be marked at biosensor method. CONCLUSIONS HBV DNA extracted from clinical samples were directly detected using PNA biosensor and PCR amplification was successfully bypassed.


To cultivate students having creative ability,it is necessary that to strengthen their consciousness of making innovations and to urge them creatively thinking,in the teaching of mathematics, teachers can start with the following way:design question and lead students make divergent,contrary side thinking,strengthen exercises of mathematical guess.


The Earth's climate has varied naturally throughout geological time, but there is very strong evidence that anthropogenic activity since the Industrial Revolution has superimposed a further climate change component onto the background of this natural climate variability and change. In this paper, the causes of climate change both natural and anthropogenic are summarised. The models which are used to simulate the climate, and to make projections of future climate change, are described, and the sources of uncertainty in these projections are also discussed. Recent projections of changes in temperature, precipitation and sea level are outlined, at global, UK and South-West England scales. Finally, some potential links between climate phenomena and geological/geomorphological hazards in South-West England are investigated, highlighting a selection of the current challenges in climate impacts research and the science of climate risk.


in 2000 primary INH resistance in immigrants was reported to be 9.4%. In a survey of patients referred to the General Hospital of Verona from January 2000 to June 2003, among 231 isolates of Mycobacterium tuberculosis, 28 of 41 of strains (68.3%) resistant to at least one antituberculosis drug were from immigrants (23.9% of cases in this category of patients). Overall resistance to INH was detected in 23 strains (9.9%); 60.8% of these were isolated in immigrants from the African continent (mainly Senegal, Ghana, Ivory Coast, and Nigeria) who were infected by INH-resistant strains in 22.2% of cases. These data highlight that in the area of Verona, the INH resistance rate among immigrants is much higher compared to the national level. Therefore, the use of INH as LTB treatment could be inadequate in nearly one of four African immigrants. We believe that it is essential to evaluate the origin of immigrants in a specific area while preparing national and local guidelines for LTB treatment because of the possibility of different resistance patterns. Considering the high level of INH resistance in some endemic areas, regimens including rifampin should be recommended. Nevertheless, following the recent withdrawal of the RZ regimen in the United States, new options for LTB treatment are urgently needed. In the meantime, based on a cost-effectiveness evaluation, we would suggest that in young immigrants from high tuberculosis prevalence countries with known high INH resistance, especially if at increased risk, such as HIV-positive subjects, RZ could be still considered in absence of any hepatopathy.


This paper discussed the implementation of the planar dipole antenna using Koch curve structure at UHF band application. The 2nd iteration of Koch curve is arrange in series to reduced the height of the antenna and the ground plane is optimized during simulation. The simulation and measurement of return loss and radiation pattern have been discussed in this paper. The operating frequencies of the antenna is between 680 MHz to 730 MHz which can be used for received channel 57 until 62 in the UHF band frequency.


Roger Dean: piano, computers; Sandy Evans: saxophones; Phil Slater: trumpets; Hazel Smith: speaker; Greg White: computers, sound projection; ABC Classic recording, Eugene Goossens Hall, ABC Ultimo Centre, Sydney, 2004 (Duration 7:31,Digitally recorded from ABC Classic FM, 21/04/05)


Background: The radius is one of two long bones that make up the human antebrachium, the other bone being the ulna. With the recent advent of improved implants used for open reduction and internal fixation of distal radius fractures, external fixation of these fractures has fallen out of favour. Hence; under the light of above mentioned data, we planned the present study to assess the outcome of ligamentotaxis of fracture of distal end radius by distractor apparatus. Materials & methods: Twenty five Cases of age group 20-50 years and of either sex with intra/juxtaarticular fractures of distal radius were taken for the present study. As soon as the patient is fit for surgery, the patient was operated under appropriate anaesthesia, taking all aseptic precautions with proper cleaning and draping. Post-operatively patient was advised active movement of the adjacent joints as early as possible. Follow-up was done and all the patients were analysed. Gartland and Werley is a mixed subjective and objective assessment. Results: Mean duration of surgery was found to be 63.58 minutes. Mean Gartland and Werley score was found to be 4.72. According to Gartland and Werley score grading, excellent results were obtained in 24 percent of the patients (6 patients), while good results were seen in 64 percent of the patients (16 patients). Fair results were obtained in 12 percent of the patients (3 patients). Mean time for complete radiographic union was 14.8 weeks. Conclusion: The efficacy of ligamentotaxis in neutralizing detrimental compression forces, which are likely to cause displacement of unstable fracture with radial shortening, is a significant and increasingly appealing advance in the management of distal radius fracture.


The strength and elastic modulus to provide an excellent glass cloth and a glass fiber sheet material using the same. Glass fabric, to the fiber diameter in a melt-spinning a molten glass to a glass composition to be a raw material of the glass fiber bundling a 3 ~ 6 ㎛ range of the glass fiber is obtained by weaving the glass yarns (yarn) made. The glass fibers, with respect to the total amount is 57.0 ~ 63.0% by weight of SiO


The one dimensional mathematical model of the air drag in melt blowing process, which had been put forward by Uyttendaele and Shambaugh is improved. The influence of the density and the specific heat capacity of polymer melt at constant pressure changing with polymer temperature on fiber diameter are studied. The power - law model is introduced as the constitutive equation. The influences of polymer volume flow rate, initial polymer temperature, initial air velocity and initial air temperature on fiber diameter are discussed.


This chapter introduces two new GIS-supported methods of measuring accessibility to primary healthcare. The improved floating catchment method defines the service area of physicians by a threshold travel time while accounting for the availability of physicians. The gravity-based accessibility method considers two factors: travel times from service providers (a nearby supply is more accessible than a remote one) and competition intensity by residents for such a service (measured by gravity-based potential). The methods are applied to examining accessibility to primary care in the northern Illinois region in 1990 and 2000. The GIS-based methods may be used to help the U.S. Department of Health and Human Services and state health departments define health professional shortage areas.


In this article we consider international migration by drawing on the life stories of Gujaratis presently living in Wellingborough, to illustrate the varied and complex reasons for migration, and the contrasting experiences of men and women migrants.


The local drug application device basically captures the drug administered in the area between two balloons by inflating two balloons around the device tube within the canals, bladders and cavities. The drug delivers its effect intensively during the desired time between the two balloons only. The drug that is unable to go beyond the two balloons has no adverse or unnecessary effect on the other tissues. It is also selective in the drug application area (2) by means of the filler balloon (17). The device may be used for cancer treatment and infection treatment. In the case of infection treatment, an antimicrobial drug is administered to the area, the PH and oxygenization of area is modified and it is possible to attack microorganisms in these three ways. In order to benefit from the synergistic effect of oxygen and certain antibiotics, both can be administered at the same time.


In the 80s and 90s of the 20th century, women's literature in Russia began to rapidly develop and become recognized as a special phenomenon - for the first time after the last turn of the epoch: Soviet literature was rarely considered in Russian literary criticism from a gender point of view. The creativity of modern women writers became a vivid phenomenon in the context of the Russian literary process, revealed a unique female view of many socio-psychological problems, and in its own way reflected the historical turning point experienced by Russian society. In China, traditionally sensitive to Russian culture, the growth of female literature in Russia was noted almost immediately, and Chinese scientists have so far achieved considerable results in studying the specifics of themes, plots, typology of heroes, artistic styles, and the language of Russian female literature. This article is aimed at summarizing the current state of research on the work of Russian writers in China. It presents both generalizing works and materials devoted to individual writers' personalities (L. Petrushevskaya, T. Tolstaya, L. Ulitskaya).


Quantitative magnetic resonance imaging, especially T1/T2 relaxation time mapping is increasingly used in both research and clinical practice. The purpose of this study was to assess the precision and cross-platform repeatability and reproducibility of T1 and T2 mapping modules on GE and Siemens MRI platforms, with the goal of standardization across vendors. A standard MRI quantitative phanom was scanned on four scanners, twice per scanner. GE data was processed with a custom script. Our results show high intraplatform repeatability, but showed high inter-platform discrepancies for both T1 and T2 results.


In order to obtain a wide-range magnetoelectric (ME) response on a ME nanocomposite 11 that matches industry requirements, Tb0.3Dy0.7Fe1.92 (Terfenol-D)/CoFe2O4/P(VDF-TrFE) flexible 12 films were produced by solvent casting technique and their morphologic, piezoelectric, magnetic 13 and magnetoelectric properties investigated. 14 The obtained composites revealed a high piezoelectric response (≈-18 pC.N-1) that is independent 15 of the weight ratio between the fillers. In turn, the magnetic properties of the composites were 16 influenced by the composite composition. It was found that the magnetization saturation values 17 decreased with increasing CoFe2O4 content (from 18.5 to 13.3 emu.g-1) while the magnetization and 18 coercive field values increased (from 3.7 to 5.5 emu.g-1 and from 355.7 to 1225.2 Oe, respectively) with 19 increasing CoFe2O4 content. 20 Additionally, those films showed a wide-range dual-peak ME response at room temperature 21 with the ME coefficient increasing with weight content of Terfenol-D, from 18.6 mV.cm-1.Oe-1 to 42.3 22 mV.cm-1.Oe-1. 23


When Celltech Ltd was formed in 1980 it profoundly affected a number of government agencies concerned with technology transfer. The company emerged from the National Enterprise Board and the Medical Research Council, and an agreement between these two organizations circumvented the then existing arrangement whereby most government-funded research had first to be offered for commercialization to the National Research Development Corporation. This agreement was instrumental in changing the existing system. The paper describes the pressures which led to the novel agreement, the rows which it caused, and the consequences it had for technology transfer from academia to industry.


Only a quarter of people in England with epilepsy and ongoing seizures are referred to an epilepsy specialist, a survey of nearly 1000 patients has found.1

In addition, less than a 10th (7%) of people who presented with a first seizure were referred to a specialist within two weeks, and just one in seven (14%) had a written care plan. This level of care falls short of draft quality standards for epilepsy from the National Institute for Health and Clinical Excellence, which recommend that all children and adults be seen by a specialist within two weeks of the first seizure, be given a written care …


We demonstrate pulse retrieval from dispersion-scan and FROG traces using a genetic algorithm. The algorithm is extremely robust even for complex pulse shapes, resilient to noise, and can reliably compensate for spectral efficiency variations.


Parametric imaging using Patlak graphical method has been widely used to analyze dynamic PET data. The conventional way to generate Patlak parametric image is to reconstruct dynamic images first and then perform Patlak graphical analysis on the time activity curves pixel-by-pixel. In this paper we present a Bayesian method for reconstructing Patlak parametric images directly from raw sinogram data by combining the Patlak plot model with image reconstruction. A preconditioned conjugate gradient algorithm is used to find the maximum a posteriori solution. We conduct computer simulations to validate the proposed method. The comparison with conventional indirect approaches shows that the proposed method results in more accurate estimate of the parametric image


2001;111:2183–2186. 5. Cirak MY, Ozdek A, Yilmaz D, et al. Detection of Helicobacter pylori and its CagA gene in tonsil and adenoid tissues by PCR. Arch Otolaryngol Head Neck Surg. 2003;129:1225–1229. 6. Bulut Y, Agacayak A, Karlidag T, et al. Association of cagA(+) Helicobacter pylori with adenotonsillar hypertrophy. Tohoku J Exp Med. 2006;209:229–233. 7. Morinaka S, Ichimiya M, Nakamura H. Detection of Helicobacter pylori in nasal and maxillary sinus specimens from patients with chronic sinusitis. Laryngoscope. 2003;113: 1557–1563. 8. Karlidag T, Bulut Y, Keles E, et al. Detection of Helicobacter pylori in children with otitis media with effusion: a preliminary report. Laryngoscope. 2005;115:1262–1265. 9. Yilmaz MD, Aktepe O, Cetinkol Y, et al. Does Helicobacter pylori have role in development of otitis media with effusion? Int J Pediatr Otorhinolaryngol. 2005;69:745–749.


Concealed object detection in millimeter wave (MMW) images has gained significant attention in the realm of public safety, primarily due to its distinctive advantages of non-hazardous and non-contact operation. However, this undertaking confronts substantial challenges in practical applications, owing to the inherent limitations of low imaging resolution, small concealed object size, intricate environmental noise, and the need for real-time performance. In this study, we propose Swin-YOLO, an innovative single-stage detection model built upon transformer layers. Our approach encompasses several key contributions. Firstly, the integration of Local Perception Swin Transform Layers (LPST Layers) enhanced the network's capability to acquire contextual information and local awareness. Secondly, we introduced a novel feature fusion layer and a specialized prediction head for detecting small targets, effectively leveraging the network's shallow feature information. Lastly, a coordinate attention (CA) module was seamlessly incorporated between the neck network and the detection head, augmenting the network's sensitivity towards critical regions of small objects. To validate the efficacy and feasibility of our proposed method, we created a new MMW dataset containing a large number of small concealed objects and conducted comprehensive experiments to evaluate the effectiveness of overall and partial improvements, as well as computational efficiency. The results demonstrated a remarkable 4.7% improvement in the mean Average Precision (mAP) for Swin-YOLO compared with the YOLOv5 baseline. Moreover, when compared with other enhanced transformer-based models, Swin-YOLO exhibited a superior accuracy and the fastest inference speed. The proposed model showcases enhanced performance and holds promise for advancing the capabilities of real-world applications in public safety domains.


The culmination of a year-long lecture series cosponsored by The Century Foundation and the City University of New York Graduate Center's Center for Urban Research, 'Rethinking the Urban Agenda' takes up the challenge provided by a changing of the guard in New York City government-the election of a new mayor and city council-to outline a new conceptual and political road map for New York City's future and, in many important respects, for the future of urban America. Contributors include Gordon Berlin (Manpower Demonstration Research Corporation), Alan Brinkley, J. Phillip Thompson, and Lawrence D. Brown (Columbia University), Angelo Falcon (Puerto Rican Legal Defense and Education Fund), Norman Fruchter and Amy Ellen Schwartz (New York University), Nathan Glazer (Harvard University), Michael Jacobson, (John Jay College), Gregory Mantsios (Queens College), James Parrott (Fiscal Policy Institute), Martha E. Stark (Baruch College), and Doug Turetsky (United Neighborhood Houses).


There are 20,000 new cases of African trypanosomiases reported each year and some 50 million people residing on a third of the African continent are at risk of infection.' In the case or Chagas' disease, the South American form (T . cruzi), no completely suitable drugs exist for prevention or treatment? Chagas' disease is prevalent throughout Central and South America, where 16 to 18 million people are infected and 200,000 new cases are reported each year. There is also a great need for the development of new drugs for the treatment of leishmaniasis. A recent World Health Organization report noted that a major goal for African trypanosomiases is the identification of enzyme targets for drug intervention.' Trypanothione reductase presents one such target. The role of glutathione as an intracellular protectant is of chemotherapeutic interest since trypanosomes lack adequate defenses against H,O, and H,O,-related free radicals such as OH ?4.536 The parasite must exist in an environment of high oxygen tension, so defense mechanisms against oxidative stress are crucial to development. In mammals and most other aerobes, the tripeptide glutathione plays a key role in the antioxidant defense process.' Glutathione reductase [ EC 220.127.116.11, a flavoprotein disulfide reductase, acts to maintain a ratio of free thiol (reduced form) to disulfide (oxidized form) of about 300: 1. Reduced glutathione protects against oxidative stress both nonenzymatically by free-radical scavenging through thiol/disulfide exchange and enzymatically by peroxide metabolism (FIG. 1). Examination of the mechanism of glutathione metabolism in trypanosomatids led to the discovery that they do not enzymatically reduce glutathione; instead glutathione is reduced via a nonenzymatic thiol/disulfide exchange with a cyclic spermidine-containing glutathione-based peptide, trypanothione, that is apparently unique to Kinetoplastidas-" (FIG. 2). The development of a protocol for the synthesis of trypanothione and related compounds has led to an examination of the substrate specificity of trypanothione reductase."3'2 Purification and characterization of trypanothione reductase from a variety of sources showed that trypanothione reductase and human erythrocyte glutathione reductase, which have many of the same physical characteristics, possess mutual exclusivity for their respective substrates."-" The sensitivity of the trypanothione system to the ornithine decarboxylase inhibitor DFMO 16~17 and arsenicals,'* coupled with the development of futile redox cyclers,19 demonstrates that trypanothione reductase is a unique trypanosomal enzyme that may be exploited for the development of novel trypanocidal agents. Trypanothione reductase represents an ideal enzyme for the application of computer-assisted conformational analysis, given its high degree of homology with human erythrocyte glutathione reductase. An understanding of the differences in the binding