The nature of contemporary celebrity demands the negotiation of publicness and privacy. Given the increasingly intrusive presence of the paparazzi, entertainment media, and fans (from obsessed 'stalkers' to well-wishers), celebrities need to regulate but also publicise their 'front stage' public persona. While this is usually achieved with a degree of comfort, at certain times their space is threatened. Through a case study of the 2003 court case concerning unsolicited photographs of the wedding of Catherine Zeta-Jones and Michael Douglas, published in Hello! magazine, this paper examines the policing, staging and legislative defence of celebrity privacy. It is suggested that celebrities' role in public is compromised by their extreme recognisability.


Background & Aims: Recent studies suggest that agrammatism is not a major feature of progressive nonfluent aphasia, at least not in the earlier years post-onset. We investigated the emergence of syntactic impairments over a 3-year period in CS, a 63-year-old man 8 years post-onset of progressive speech difficulties. CS has a range of progressive cognitive impairments, including progressive nonfluent aphasia, and limb and other apraxias (with a progressive non-aphasic and mostly non-dysarthric speech deterioration), but relatively intact intelligence, perception, orientation, long-term memory, semantics, and phonology. Writing impairments did not emerge until some 8 years after naming and speech impairments were first noticed, and after CS became mute. Methods & Procedures: We undertook detailed longitudinal examination of word and sentence writing and syntactic comprehension across a range of tasks and examined the impact of short-term memory. We were concerned to examine the data for evidence of agrammatic features, particularly in noun and verb use, and use of formulaic and simplified syntactic structures as the condition progressed. Outcomes & Results: Analysis showed a progressive emergence of deficits on tests of written syntax, syntactic comprehension, and auditory-verbal short-term memory. There was a progressive reduction in verb and noun use, but this was related to the kind of stimulus used. Features of agrammatism were evident in writing with a progressive dependence on formulaic and simplified syntax. Conclusions: It may be that agrammatism in PNFA is a feature that develops late in the progression, showing up only in writing because it is masked in speech by motor speech impairment. Increasing reliance on formulaic and simplified structures with progression suggests compensatory adaptation of CS's system. Impairments appeared to emerge in parallel with deterioration of syntactic comprehension and phonological short-term memory.


The blood plasma contents of ANP,AT-Ⅱ,TXB_2 and 6-Keto-PGF_(1α) were determined simultaneously by RIA method in 30 cases of aetue cerebral infarction with- in one week after onset of disease and in 30 cases of healthy adults.It was found that the patients' ANP and TXB_2 increased;6-Keto-PGF_(1α) decreased;AT-Ⅱ had no obvious ehange;the ratios of ANP/6-Keto-PGF_(1α) were all increased.The fact pointed out that the imbalance of ANP and AT-Ⅱ,TXA2 and PGI_2 has something to do with the acute cerebral blood vessel occlusion,It is also found that the plasma ANP and TXB_2 contents of the cerebral infarction group show obvious positive correla- tion. The secretion of ANP may be influenced by the hemodynamic changes caused by the vessel constricting effect of TXA_2.


A hydrogen detachment reaction which creates sp2 carbons in the surface processes of methane plasma chemical vapor deposition (CVD) is calculated using an ab initio molecular orbital method. This reaction is calculated to be kinetically more favorable than the hydrogen detachment reaction which creates sp3 carbons. The sp3 formation reaction is thermodynamically more favorable than the sp2 formation reaction. The substrate temperature dependence of the sp2/sp3 ratio and the hydrogen contents of a-C:H films produced by methane plasma CVD are experimentally studied using Raman and IR spectroscopy, respectively. The substrate temperature dependence of the reaction mechanism is elucidated on the basis of calculated and experimental results.


The Health Information Systems Programme (HISP) is a sustainable and scalable research project enabling and supporting health information systems implementation in more than 100 developing countries. In this paper, we present the historical roots, the status, and discuss the future of HISP and its software (DHIS2). We also reflect on factors contributing to the project's global success and find the open and participatory approaches to HISP and DHIS2 software development, and implementation in countries as key. For the future, we discuss strategies to stabilise as well as grow the HISP and DHIS2 community into a sustainable ecosystem.


The X-ray synchrotron emission of each of the young supernova-remnants (SNRs) SN1006, Kepler, Tycho, RCW86 and Cas A, is roughly given by $\nu L_{\nu}\sim 10^{45}\rm{erg}/t$, where $t$ is the remnant's age. The electrons emitting the X-ray emission cool fast, implying that the X-ray emission is calorimetric and equal to half of the cosmic ray (CR) electron acceleration efficiency (per logarithmic interval of particle energies, at multi TeV energies). Assuming Sedov-Taylor expansion, the resulting CR electron yield per SNR is estimated to be $E^2dN_e/dE\approx 6\nu L_{\nu}t \sim 10^{46}\rm erg$. This is about two orders of magnitudes below the required amount for explaining the observed electron CRs at $E\sim 10\rm GeV$. Possible resolutions are 1. a soft acceleration spectrum allowing much more energy at $E\sim 10\rm GeV$ compared to $E\sim 10\rm TeV$, 2. an increased acceleration efficiency at later phases of the SNR evolution (unlikely), or 3. SNRs are not the source of CR electrons.


INTRODUCTION AND OBJECTIVE: The use of telemedicine websites such as forhims.com (Hims ) and getoroman.com (Roman ) is becoming increasingly common for the diagnosis and treatment of erectile dysfunction (ED). However, the actual market share that telemedicine websites capture is not well characterized. We sought to determine patterns of online traffic for these two most popular websites in order to understand trends in utilization of Men's Health commercial telemedicine services. METHODS: Using SEMrush , an advance-marketing software platform, we analyzed the web traffic reports for Hims and Roman . As a control, we used Google Trends to determine search volume for "erectile dysfunction" over time. Reports estimated approximate monthly web traffic from January 2018 to August 2019, along with analysis of how users were directed to each website: direct access or referral from another site, search engine, social media or paid advertisement. RESULTS: During the study period, Hims and Roman had an average of 2.31 million and 1.96 million visits per month, respectively. Since January 2018, site traffic increased by 318% and 721%, respectively. In contrast, during the same period, Google Trends showed stable search volume for the term "erectile dysfunction." The majority of website visits to Roman and Hims were directed from google.com (27.3%) or from users directly accessing the website (24.2%). Among all search engine referrals, Google comprised 96.2% of the website referrals. An additional 7.9% of users were directed to these websites through paid Google advertisements. The largest referring social media websites were Facebook and YouTube , which only contributed 2.5% and 0.8% of total traffic, respectively. CONCLUSIONS: Website traffic to telemedicine sites for the treatment of ED has increased dramatically over a relatively short period of time. With approximately 4 million monthly visits, these websites represent a growing source of information and possibly treatment for men with ED. Given their increasing popularity, it is critical that clinicians begin to understand which patients are utilizing these resources, how they are being accessed, and the potential limitations and downstream implications of their use.


A t Determination of liquefied petroleum gas quantitative parameters is considered Radiofrequency measurement method is proposed providing highly accurate determination of level (gasliquid interface position), densiry and mass of liquid and gaseous phases. total mass. Three RF-sensors (two level sensors, gas densiry sensor) are contained in the designed RF measuring devices. Informative parameters (resonant frequencies of electromagnptic o s c W o n s ) of these RF sensors nre jointly processed providing the needed data Experimental procedures are described and measurement resrrlts are presented Industrial RF measuring system is described


The opening of the first congress and the founding of the provisional republic government of the Soviet Government of China is a great exploration and practice for our Party to construct a people's regime.It not only profoundly influenced the Chinese Revolution but also left rich experience for the founding of the New China's Regime.REN Bi shi,the leading enormous contributions to the preparation of the congress and made the congress a great success by reaching an understanding among the representatives,promoting MAO Ze dong's leadership instead of XIANG Ying's,making personnel arrangement drafting papers and conducting election.


N-Diphenylphosphino-7-aza-benzobicyclo[2.2.1]hept-2-ene (2) behaves as a chelating phosphine-alkene ligand for Pd(0) and Pd(II), promoting direct alkyl-alkyl and indirect alkyl-halide reductive elimination reactions due to the stabilisation of the resulting bis(phosphine-alkene)Pd(0) complex.


An omni-directional stereo system has a wider field-of-view than conventional cameras, and is widely used in many applications such as robots navigation, depth estimation, and 3D reconstruction. Existing approaches usually use single viewpoint (SVP) systems as the imaging sensor. However, literature proves that an efficient SVP of an omni-directional system can only be achieved with precisely aligned mirrors of parabolic or hyperbolic profile. This enforces rigorous restriction on the configuration of camera and mirrors. In fact, some other profiles, though they do not have the SVP property, are desirable for certain reasons such as cheaper cost and more practical implementation. Therefore, in this paper, we propose both a typical nonsingle viewpoint (non-SVP) omni-directional stereo sensor and its corresponding depth estimation method based on graph-cuts optimization. The sensor comprises a perspective camera and two separate reflective mirrors that could be any radially-symmetric ones. To formulate the depth estimation more consistent with the proposed sensor, we divide the depth space of scenes with a sequence of virtual coaxial cylindrical layers, and model depth estimation as a labeling problem. In the labeling procedure, by considering the characteristics of an omni-directional image, we further devise novel tangential-neighborhood system, radial-neighborhood system, and depth-gradual-changing smoothness constraint which perform better than traditional ones. Depth estimation and 3D reconstruction for both synthesis and real scenes justify the effectiveness of the proposed method.


Based on the study of the dynamics of a dissipation-modified Toda anharmonic (one-dimensional, circular) lattice ring we predict here a new form of electric conduction mediated by dissipative solitons. The electron-ion-like interaction permits the trapping of the electron by soliton excitations in the lattice, thus leading to a soliton-driven current much higher than the Drude-like (linear, Ohmic) current. Besides, as we lower the values of the externally imposed field this new form of current survives, with a field-independent value.


This article focus for to emphasize the importance that has the first work of Georg Simmel, mainly for the studies of the culture. Resalt looks for to tar two fundamental aspects of the work of Simmel: the notion of originary condition, that one talks about to the verifiable connection between the early restlessness and those of the delayed period of the author; and the explicit idea of nation that ties here with music.


A suitable method was developed to efficiently incorporate 13C-labeled acetate into zearalenone by using solid cultures. Periodic feeding of the label during the zearalenone production phase significantly increased the label incorporation for the singly labeled acetate.


Just-In-Time (JIT) purchasing systems result in, among other things, a reduction of raw materials inventory and an increase in incoming shipment frequency. This has placed added importance on carrier selection from the buyer perspective. Previous research has identified criteria important to the carrier selection process, however buyers are left with no objective means for measuring carrier performance within these factor areas. This paper suggests a method for combining managers' subjective preferences with objective measurements when evaluating carriers for potential use. A carrier selection example is presented.


OIG Investigative Reports El Paso, TX 11/09/2010 - Federal Grand Jury in El Pso Indicts Two More in Corruption Investigation


This article expounds the eharaeteristie principle and the main transfer—mode of the eireless local area network.It introduces the operating mode of the dpread dpectrum vommunication,the principle of direct sequence spread spectrum,frequency hopping spread dpectrum,time hopping spread spectrum and chirp spread spectrum and expounds the four characteristics of the spread spectrum communication and its future application in the wireless local area network.


In mammalian peripheral nerves a crush lesion causes interactions between injured neurons, Schwann cells and haematogenous macrophages that can lead to successful axonal regeneration. We suggest that the transcriptional activator retinoic acid (RA), takes part in gene regulation after peripheral nerve injury and that RA signalling is activated via the cellular retinoic acid binding protein (CRABP)‐II and cellular retinol binding protein (CRBP)‐I. With RT‐PCR and immunoblotting all necessary components of the RA signalling pathway were detected in the sciatic nerve of adult rats. These are retinoic acid receptors, retinoid X receptors, the retinoic acid synthesizing enzymes RALDH‐1, RALDH‐2, and RALDH‐3, in addition, the cellular retinoid binding proteins CRBP‐I, CRABP‐I and CRABP‐II. Enzyme activity of RALDH‐2 was detectable in the nerve, and using a transgenic reporter mouse we found local activation of RA responsive elements in the regenerating nerve. Sciatic nerve crush as well as transection resulted in a more than 10‐fold up‐regulation of CRBP‐I, which is thought to facilitate the synthesis of RA. Both kinds of injury also caused a 15‐fold increase in transcript and protein concentration of CRABP‐II, a possible mediator of RA transfer to its nuclear receptors.


Present day endoscopic graspers are designed to be tooth-like in order to grasp slippery tissues. They are not, however, able to measure tissue tactile properties such as force and softness. This paper reports on proof of a conceptual and innovative design of an endoscopic piezoelectric tactile sensor. The sensor is capable of measuring the total applied force on the sensed object, as well as the compliance of the tissue/sensed object. Detecting the sensed objects compliance is based on the relative deformation of contact object/tissue on the rigid and compliant elements. One polyvinylidene fluoride (PVDF) film is placed between the rigid cylinder and the plate which measures the force applied on the rigid element. Another PVDF film is sandwiched between the two base plates measuring the total force applied on the sensor. The compliance of the sensed object is measured by recording the PVDF films response under different load sets. The data obtained for the force variation are plotted against the modulus of elasticity of the sensed object. Finite element modeling was used for comparison with the experimental data. The results show that the experimental and the FE approach agree with each other with a reasonable band.


Cleaning robot is a new kind of high technological product in service robot field, which not only fuses mobile robot and vacuum cleaner technology,but also has considerable commercial potentiality. In this paper a brief survey on the research status and key technology of cleaning robot and some problems in the future development are presented.


Spectra of locally precipating 36- to 317-keV electrons obtained by instrumentation on the S3-2 satellite are used to calculate energy deposition profiles as a function of latitude, longitude, and altitude. In the 70- to 90-km altitude, mid-latitude ionization due to these precipitating energetic electrons can be comparable to that due to direct solar H Lyman ..cap alpha... At night, the electrons produce ionization more than an order of magnitude greater than that expected from scattered H Lyman ..cap alpha... Maximum precipitation rates in the region of the South Atlantic Anomaly are of the order of 10/sup -2/ erg/cm/sup 2/ s with a spectrum of form j(E) = 1.34 x 10/sup 5/ E/sup -2.27/ (keV). Southern hemisphere precipitation dominates that in the north for 1.1


A wide variety of disease states give rise to intra-abdominal infection 1. While varying according to age, gender and geography, the three most common causes of generalized peritonitis in low-income countries are probably appendicitis, perforated duodenal ulcer and typhoid perforations, in no particular order 2. Causes and patterns of peritonitis were evaluated in patients surgically managed at Nsambya hospital. This study was aimed at determining the causes and patterns of peritonitis in patients managed surgically at St. Francis Hospital, Nsambya. Methods: This was both a retrospective and prospective study of patients with peritonitis who underwent surgical treatment at Nsambya Hospital over a 15-months period from January 2012- to March 2013 inclusive. A total of 62 patients were included in the study. Results: Of the 62 patients, 29 patients were retrospective and 33 patients prospective, 46 (74.2%) were males while 16 (25.8%) were females, giving a male to female sex ratio of 3:1. The mean age at presentation was 30.79 (SD 15.55) years, the youngest being 0.103) and hospital stay (p = 0.257) between those who were operated within 24 hours of onset of and those operated after 24 hours of onset of Wabwire Ntirenganya, Ntakiyiruta and and after of The that the major causes of peritonitis was ileal (25) and colonic perforation (3) and bacterial from the accounted for the after of onset of symptoms compared to our study where there was less virulent bacterial contamination from the perforated peptic ulcers.


Some physiological indexes of Carallia brachiata, Ficus microcarpa and Phoebe zhennan seedlings were measured under low temperature stress(6°C )for 2, 4 and 6 d and 2 d after release by chilling, respectively. The results show that with increasing stress time chlorophyll content of C. brachiata and F. microcarpa increased followed by a decrease, whereas P. zhennan decreased followed by an increase; soluble sugar content of C. brachiata increased followed by a decrease and then increased again, F. microcarpa decreased followed by an increase, whereas P. zhennan tended to increase; soluble protein content of C. brachiata and P. zhennan tended to increase, whereas F. microcarpa kept at a steady condition. Proline content of the seedlings of three species increased followed by decrease; The SOD activity content of C. brachiata fluctuated slightly and then significantly decreased, F. microcarpa and P. zhennan fluctuated slightly. The MDA content of C. brachiata and P. zhennan increased followed by a decrease, F. microcarpa gradually increased. The two days after low-temperature release, contents of chlorophyll, soluble sugar, soluble protein, proline of seedlings of the three species were higher or similar to control levels; The SOD activity of C. brachiata was lower than the control, and the other species was similar to the control; The MDA content of C. brachiata was lower than the control, P. zhennan was higher than the control, whereas F. microcarpa was similar to the control. The cold-resistance ability of seedlings of the three species was evaluated using principal component analysis, which decreased in order of C. brachiata > P. zhennan > F. microcarpa.


This report documents the collection of experimental test data and presents performance characteristics for the AeroValve brand prototype pneumatic bidirectional solenoid valves tested at the Oak Ridge National Laboratory (ORNL) in July/August 2014 as part of a validation of AeroValve energy efficiency claims. The test stand and control programs were provided by AeroValve. All raw data and processing are included in the report attachments.


Mobile network is used to transmit signals for telemedicine dynamic ECG monitoring system.In this way,ECG monitoring can be performed to patients at all times and places,thus really realizing telemedicine dynamic ECG monitoring.In the paper,the system is studied.The discussion on how to transmit ECG signals and feedback the diagnostic message through mobile network is presented in detail.


Trailing Suction Hoper Dredger(TSHD) is widely-used equipment in construction of channel,underwater tunnel and waterway dredging engineering.Under deepwater and difficult circumstances,dredging accuracy control of TSHD is an important issue to be solved.Considering wind,wave,current,ship maneuvering force,seabed reacting force,swell compensator and its lag,as well as other combined influencing factors,a mathematical model of the coupled motion of TSHD and draghead is built,which is tested and verified by real-ship data.The effects of water depth,wind,wave and current,etc,on the TSHD-draghead motion are investigated through an example.The results provide the basis of the calculation of draghead motion as well as the control of overdepth and overwidth dredging.


Alzheimer's disease (AD) is the most common form of dementia. Because any antidementia treatment is not likely to reverse existing neuronal...


Optical four-level pulse amplitude modulation (PAM-4) is investigated for data center applications with reach significantly greater than 10-40km standards, such as for synchronous data mirroring up to 100km or asynchronous applications with reaches beyond 100km.


Christian students' involvement in the school Islamic programs such as wearing Muslim clothing, participating in the seven-minute Islamic sermon, and joining Islamic classes are often considered a compliance attitude. Instead, it is a process of self-adaptation because they attend a school within a Muslim majority environment.  Moreover, this camouflage represents their resistance to the school rules. This article discusses how Christian students in two state schools in Padang behave in the framework of Islamic customs. Based on the theories of Jean Baudrillard's simulacra and James C. Scott's resistance, the results of this study show that Christian students in two state schools in Padang tend to be obedient and interested in Islamic practices. For instance, they imitate the way Muslim students dress so that they look similar to Muslim students. This attitude pleases their Muslim teachers and fellow students. In addition, Minang people in their neighborhood also amaze and always refer to these Christian students' attitude as a model to be followed.


Date of settlement: July 2009; PSLA: £7000; Total award: £7200 Consultant radiologist's failure to correctly interpret ultrasound scan resulting in unnecessary removal of breast implant. Failure by the consultant plastic surgeon to provide necessary implant information to the consultant radiologist and failure by both consultants to discuss the case prior to undertaking the ultrasound scan. As a result, removal and replacement of the implant was performed on the basis that the ultrasound scan findings were misinterpreted as showing a breast implant rupture. On removal, the implant was found to be intact.


[Objective] To establish an analytical method for the determination of diethylstilbestrol in aquatic products by HPLC. [Method] The sample was extracted by methanol,qualitative analysis by the retention times and quantization by external standard. [Result] The melamine showed good linearity in a detected concentration range with good correlation coefficient( r = 0. 999),the limit of detection was 0. 05 mg / kg,the recoveries were generally 89. 0%- 98. 5% with RSD 1. 1%- 4. 1%. [Conclusion]The method can detect diethylstilbestrol residues in aquatic products fast,accurate,applicable to the work of aquatic quality detection.


Small and medium businesses are considered to be one of the most important drivers of economic growth in most economies throughout the world. Micro, Small and Medium Enterprises (MSMEs) are considered to be the main drivers of economic growth in India, and the sector fosters a balanced regional growth. The MSME sector plays a vital role in Uttarakhand's production, investment and job creation. The sector is helping in mitigating the problem of migration and underutilisation of natural resources. This article focuses on analysing the current status and the problems faced by MSMEs in Uttarakhand. The research also examines the state's MSMEs before and during the COVID-19 pandemic. The sector faces a new set of issues as a result of COVID-19. The study also looks at government support for the business during the COVID-19 pandemic. An extensive literature survey of different research papers, articles and government reports has been done to identify problems and incentives available to MSME units operating in the state. The current incarnation of the MSME sector in Uttarakhand is investigated using descriptive analysis. The article concludes that despite various incentives the MSME sector is facing various challenges in the state which need to be addressed for smooth functioning of the sector.


This communications presents the results of a search for low electrical impedance in the areas of acupuncture points. The method involved placing a search grid on areas of the skin and measuring the impedance in random order using several replications. The data does not support the location of acupuncture points by electrical impedance. In addition, it shows that the stratum corneum layer of the epidermis contributes to most of the impedance and that it is easily broken, resulting in dramatically lowered skdn impedance. This leads to the conclusion that probing in the immediate area of charted acupuncture points can destroy the integrity of the stratum corneum layer, resulting in the lowered impedance sought for.


Abstract To characterize the nature of humus in paddy soils, a comparison was made between the properties of humus in paddy soils and those in adjacent unflooded arable soils. Rice cultivation generally brought about a considerable increase in organic matter and in the PQ-value, with the exception of Andosol-paddy soils in which organic matter tended to decrease somewhat and the PQ-value remained virtually unchanged. The humification degree of humic acid as judged from Δ log k and RF values was generally lowered by rice cultivation except in the case of Yellow soil-paddy soil in which humic acid was originally low in the degree of humification. The accumulation of poorly humified humic acid may be a characteristic feature common to all paddy soils. These changes by rice cultivation are observed only in the upper part of the profiles, and seem to be associated with seasonally flooded conditions ot paddy soils. Iron oxides accumulated in subsurface soil have virtually no effect on the properties of humus.


First, the evolution history of avionics equipments is described in brief in this paper; then, the development characteristics in the early part of the 21th century and its unchanged factor in development are presented emphatically; finally, some propositions on the avionics development in our country are given.


Calculation experiment of briquetted ore using multi-function computerized nucleus steelyard shows:the use of the nucleus steelyard is easy and sesults is good,it can satisfy almost the demand for briquetted ore calculation.The apparatus provides reliable basis for promptly mastering producing condition and accurately analyzing producing cost.


The invention discloses an unlocking method for a mobile device. The unlocking method is applied to the mobile device provided with a touch screen. The unlocking method for the mobile device comprises the following steps: displaying an unlocking icon consisting of a plurality of segments which are arranged adjacently on the touch screen; generating at least one touch signal in sequence by using the touch screen; moving corresponding segments from a first position to a second position in an exchange way according to each touch signal; judging a combination pattern consisting of a plurality of adjacent segments having the same characteristics; when the combination pattern is consistent with a set pattern, switching the mobile device from a locking mode to a normal mode. Therefore, the unlocking icon has a plurality of characteristics, and each segment individually has one of the characteristics.


Infection is the largest cause of infant death. One of infection in infants is neonatal sepsis. Neonatal sepsis is a severe bacterial infection that spreads throughout the body of a newborn baby. Incidence of sepsis in developing countries is fairly high, 1.8 to 18 per 1000 live births with CFR 12-68%. To determine the characteristics of neonatal sepsis patients who are hospitalized at RSU Dr. Pirngadi Medan in 2005-2009 with research descriptive case series design. Population and sample numbered 119 persons (total sampling). Data obtained from medical records, analyze data using Chi-square, t-test and ANOVA. The results obtained proportion of patients with neonatal sepsis based on the characteristics of infants is early neonatal 80.7%, sex ratio of 1,3:1, not twins 88.2% and low birth weight 50.0%. The proportion of patients with neonatal sepsis based on maternal characteristics such as age 20-35 years 77.9%, 48.7% high school, Housewife 79.7%, 97.4% married, less-month gestation 56.9%, history of normal deliveries 67.8%, 52.4% premature rupture of membranes, amniotic fluid and green and smelled of 50.0%. Referral midwife/clinic/maternity home 43.7%, 57.1% Jamkesnas, the average treatment time of 9 days, 47.1% died. CFR of early neonatal 47.9%, female 56.9%, 47.6% babies are not twins, and very low birth weight 62.5%. CFR neonatal sepsis who were born in the hospital 59.1%. There are significant differences in proportions between age based on birth weight (p=0.015). There is no statistical test can be done birth weight based on gestational age with Chi Square because there are three cells (33.3%) had a value Expected count <5. There was no significant difference between the origin of a referral based on the situation when home (p=0.272). There was no significant difference between the old treatment based on the average cost sources (p=0.317). Length of the average nursing home patient who was in good health were significantly longer than the home at the request of parents and death (p=0.000). RSU Dr.Pirngadi Medan, to increase the quality of curative health services and early diagnosis especially for neonatal sepsis in the neonatal mortality derive, and to seek the listing of more complete patient data on the status of the card.


Alos-Ferrer and Ritzberger (2013) specify each node in a game tree as the set of outcomes that yet remain conceivable. In contrast, Streufert (2015a) specifies each node as the set of choices that have already been made. The symmetry suggests that the two formulations are "dual" in some sense. In this paper I develop this duality. In particular, I define suitable conversion procedures, and show that there is a one-to-one correspondence between choice-set forms and outcome-set forms. The analysis encompasses discrete forms with finite or infinite horizons.


The necessity to consider for delayed influence of independent variables on predictand has been studied. It has been demonstrated that the existence of unaccounted time lag makes it impossible to obtain correct training samples and impairs quality of forecasting. Mathematical statement of finding of optimal time lag for one and several independent variables is formulated for the case of application of methods of regression analysis. Mathematical formulation of construction of forecasting neural network is obtained for the case of non-zero delay for one and several independent variables. It has been determined that the problem of neural network construction with consideration for non-zero delay is reduced to the problem of finding of vector of optimal lags at which quality functional described by forecasting error becomes optimum for all sets. A method of determination of optimum time lag is proposed based on finding for maximum of absolute forecasting error at elimination of input corresponding to specified lag value.


One of the most important issues in improving solar cell efficiency and reducing the cost is to introduce the charge carriers through defect control and reduce the recombination of photo-generated carriers. For example, CdTe is one of the leading materials for low cost, high efficiency thin-film solar cell absorbers. However, CdTe solar cell currently has only achieved a efficiency of about 20%, which is relatively low compared with its theoretical limit 30%. One of the main reasons is because of the low majority carrier concentration of CdTe and low carrier life time caused by defect-induced carrier recombination. Similar issues also affects ∼ the application of other leading thin-film solar cells such as Cu(In,Ga)Se2 and Cu2ZnSn(S,Se)4, where doping difficulty has led to low open circuit voltage. Using first-principles band structure methods we systematically studied the defect properties in thin-film solar cells, including calculation of the defect formation energies and transition energy levels of intrinsic and extrinsic point defects and defect complexes, grain boundaries, defect diffusion barriers, and carrier concentration as function of atomic chemical potentials and temperature. From the calculated results, we investigate the limiting factors for p-type and n-type doping and the potential non-radiative recombination centers in thin-film solar cell materials. Possible approaches to control the doping and reduce the recombination centers, as well as passivation of grain boundary defect levels are discussed. General understanding of the chemical trends of defect properties in thin-film solar cell will also be discussed.


Most metals will corrode within a certain range of eletrical solution potential and solution pH. At potentials more negative than this range, corrosion ceases (cathodic protection). At potentials more positive than this range, several metals become passive. For these metals the potentials can be shifted electropositively in to passive range through anodic protection (AP). AP is especially applicable to sulfuric acid (H2SO4) and caustic liquor environments. It often permits a designer to use a low alloy rather than a corrosion-resistant metal, at an overall cost saving.


Purpose – The cosmetics industry is a traditional high value-added industry in terms of the domestic demand, small batch production systems,...


approved: Eric Walkingshaw Variational programming supports efficiently executing many related programs at once by encoding all of the programs in one "variational program" that captures the differences among them statically and explicitly. An open problem in variational programming is how to handle side effects—if two program variants perform different side effects, we cannot separate the effect of one variant from the other since the outside world is not variational. A potential solution is to create variation-aware execution environments for variational programs, for example, a variational file system that keeps track of file variants corresponding to program variants. However, it is infeasible to do this for all kinds of effects. Also, there are different ways to handle the interaction of effects and variation that are incompatible with each other, preventing a one-size-fits-all solution. In this thesis, we argue that algebraic effects can be used to resolve the problem of combining variation and effects by enabling programmers to flexibly and incrementally extend a variational programming environment to handle new kinds of effects. We present a proof-of-concept prototype in the Eff programming language that demonstrates how a variational programming environment can be extended to support file input/output. Crucially, such extensions are done at the library level, which enables handling new kinds of effects and handling existing effects in multiple ways, both of which are essential in variational programming applications. c ©Copyright by Ghadeer Alkubaish February 24, 2020 All Rights Reserved Integrating Side Effects in Variational Programs Using Algebraic Effects


Over the past 20 years, the use of monoclonal antibodies for therapeutic purposes has been a great ally for the treatment of various diseases. Anti-CD3 antibodies are used in the prevention of transplant organs and have the potential to treat autoimmune diseases. However, the use of these antibodies, although efficient generate an immune response because most of them have murine origin, when administered preventing the frequent use, such as OKT3. The humanization of antibodies, which is performed by means of gene manipulation, it has been a practical solution to this problem, reducing the immunogenic response elicited by the use of murine antibodies. From a human antibody library constructed from a phage display technique it is possible to build new human antibodies with the highest binding efficiency resulting in less adverse effects in helping these clinical diseases and improving the quality of life of patients. In this study, from a synthetic construct scFvRVL_gen3 containing humanized VH and VL gene and the coding sequence of the protein 3 (gene 3) was constructed using a plasmid vector pCIgRM (plasmid containing anti-CD3 murine VH and VL), resulting 4 positive clones for pCIgRVL_G3 construction. For amplification of VL of the human antibody gene library in vector pComb 3X after the 23 different test systems PCR reactions, thereby optimizing the conditions has been established for it to happen. The product was then cloned into the vector pGEM®T to study the efficiency of the amplification reaction and library diversity. The data obtained in this study are useful tools for cloning of various sequences of the amplified VL pCIgRVL_G3 VL vector by replacing the synthetic human VL library, thus allowing step forward for the construction of a human monoclonal anti-CD3 antibody.


Amniotic membrane (AM) is an avascular structure composed of three different layers, which contain collagen, extracellular matrix, and biologically active cells (stem cells). Collagen, a naturally occurring matrix polymer, provides the structural matrix/strength of the amniotic membrane. Tissue remodeling is regulated by growth factors, cytokines, chemokines, and other regulatory molecules produced by endogenous cells within AM. Therefore, AM is considered an attractive skin-regenerating agent. This review discusses the application of AM in skin regeneration, including its preparation for application to the skin and its mechanisms of therapeutic healing in the skin. This review involved collecting research articles that have been published in several databases, including Google Scholar, PubMed, Science Direct, and Scopus. The search was conducted by using the keywords 'amniotic membrane skin', 'amniotic membrane wound healing', 'amniotic membrane burn', 'amniotic membrane urethral defects', 'amniotic membrane junctional epidermolysis bullosa', and 'amniotic membrane calciphylaxis'. Ultimately, 87 articles are discussed in this review. Overall, AM has various activities that help in the regeneration and repair of damaged skin.


Although it might sometimes seem as though PFHEA and NTF are high-level and strategic forms of recognition for those working in high-level and strategic positions, this is not necessarily the case, and both have been achieved by an ever-increasing number of Learning Developers. Join us in this session if either of these is something you've been mulling over or a goal you've set yourself, and we will outline what's involved in writing an application, share with you the kinds of evidence we used in our own applications, explore how you can meet the requirements, and hopefully answer your questions about how you might proceed. Aim high!


This paper reports a MEMS gradiometer consisting of two independent, laterally oscillating masses on a single chip with integrated optical readout featuring a responsitivity of 35V/T at resonant operation. The symmetrical design of the two masses offers high accuracy and low cost by using conventional MEMS batch fabrication technology. The sensing principle is based on lateral displacement of the masses actuated by Lorentz forces which modulates a light flux passing through a stationary mask and the moving mask integrated in the masses. Phase and intensity detected by photodiodes reveal information about the uniformity of an external applied magnetic field, hence, enables the measurement of gradient-, homogeneous- and offset gradient magnetic fields.


Vaginismus is a pain disorder in which it is difficult to achieve vaginal penetration due to involuntary vaginal muscle spasms. It can occur during intercourse, vaginal examination, or insertion of a menstrual cup or tampon. Risk factors include family history, negative sex views, and cultural influences such as the value placed on the hymen. Moreover, fear of pain, injury, bleeding, and losing control can play a role in the development of vaginismus. Women with vaginismus are primarily treated with gradual desensitization to penetration using vaginal dilators. However, studies that record therapy duration and success are lacking the literature.

 This study aims to assess the success rate of gradual exposure therapy to penetration using vaginal dilators for the treatment of primary vaginismus.

 Women diagnosed with primary vaginismus between August 1st, 2019, and December 31st, 2021 at a tertiary care center in Jeddah, Saudi Arabia were included in this study. Those under 18 and those who did not use vaginal dilators were excluded. The primary investigator collected data by contacting participants over the phone to fill out a validated questionnaire, including questions from Female Sexual Function Index (FSFI) and Pain Anxiety Symptom Scale Short Form 20 (PASS-20). We project a total number of 50 participants at the end of the recruitment period by August 31, 2022. Data is collected on paper and entered into STATA 17. Demographic data included age, duration of the marriage, presence of romantic relationship prior to marriage, and education level. Our primary outcome is the degree of treatment success according to pain level and frequency scores during and after intercourse.

 The sample included 16 eligible patients. The mean age was 28.9 years (SD +/− 3.6). Almost all participants had a bachelor's degree or higher. 70% were married for two years or less with about 37% who were married for one year or less. 70% reported having a romantic relationship before marriage. We excluded 4 patients from further analysis who had never used vaginal dilators before. 33% of those who used vaginal dilators did not report any pain during or after intercourse. Only 37.5% of those who reported pain during or after sexual intercourse stated that the pain prevented them from having sexual intercourse. Among women who had sexual intercourse, 63% suffered moderate to a very high level of pain during intercourse and 25% experienced low to moderate pain after intercourse most of the time. Approximately 83% reported treatment success with vaginal dilators, while only 17% reported no success. The largest dilator size used was 6 (27%), and the most used plastic ones (50%). About 58% preferred conducting dilation therapy sessions at home instead of the clinic.

 According to our findings, more than 80% reported success with vaginal dilators for treating primary vaginismus despite still experiencing pain during or after intercourse. Interestingly more than half of the patients preferred doing exercises at home, contradicting previous studies pointing out that one session with the therapist can predict higher success in treating vaginismus.

 No


Abstract : The purpose of this effort was to investigate possible realizations of a microwave signal processing method to eliminate multipath interference in angle tracking systems. The method treats the case of a direct return wave and a single multipath return wave from a target as a two target problem, and uses a two target signal processor to decouple the two signals and eliminate the multipath interference. Theoretical constraints and limitations on possible lossy and lossless processors were evaluated using scattering matrix formulation. General solutions for the processor element values were found, and these solutions were applied to specific operating situations. Using the scattering matrix relationships, it was found that in general, a lossy processor was possible, but a lossless processor was not. Based on these results, several hardware implementations for the processor were considered, and two complete designs were ultimately presented. (Modified author abstract)


Most of organization and environment (O&E) researchs have be aimed to environment, and there are many deferences approach in organization and environment researchs. Organizations theory not enought to discuss environment contex because of limitation in organizational environment idea. Organization and environment material still interesting to discuss in research strategy.


In Malaysia, as a result of the government's initiative and future outlook in
advancing the use of innovative technologies, the Industrialised Building System (IBS)
approach is actively promoted through several strategies and incentives as an alternative to
conventional building methods. Extensive uptakes of modern Information Communication
Technology (ICT) applications are able to support the different IBS processes for effective
production. However, it is argued that ICT uptake at the organisational level is still in its
infancy. This raises the importance to identify critical drivers for effective uptake of ICT in the
IBS production management process. Critical drivers to ICT uptake were identified through
questionnaire survey with industry stakeholders which was analysed using mean index and
critical t-value with the use of SPSS software. The top ten priority ranked drivers reflect the
People, Technology and Policy elements to ICT uptake. These identified critical drivers are
able enhance ICT uptake in IBS management process in the construction industry.


Although many studies have been continuously conducted to reduce the power consumption of a resistive random access memory (RRAM) cross-point array with the current-compliance effect, it has been difficult yet to realize intrinsic self-compliance effects in an RRAM device itself. In this study, a simple oxygen-rich TiOy layer is inserted into the Al2O3/TiOx-based RRAM stack as a current suppression layer, and XPS analysis is provided to compare the stoichiometry of the TiOx and TiOy layers. A self-compliance region is formed between the different breakdown voltages of Al2O3 and TiOy layers, and a relatively thinner current path is formed in the Al2O3 layer than a device without the TiOy layer and the overall current level is significantly decreased since the TiOy layer limits the overshoot current.


This paper compares two states to determine why Illinois has a law mandating insurance coverage for infertility treatment while Nebraska does not. Case studies employing legislative transcripts reveal the debates on mandate legislation differed on three points of comparison: the specifics of the legislation, the qualities of the sponsors, and the legislative outcomes. In Illinois, the mandate legislation included an IVF component, the sponsor was a Democrat, and the legislature passed the bill. In Nebraska, the mandate legislation did not include IVF, the sponsor was a Republican, and the legislature rejected the bill. What seems to have been an important difference was the nature of the proposed policy innovation. In Illinois, the mandate legislation included coverage for IVF, and that brought a morality theme to the debate. In Nebraska, IVF and other morally troublesome assisted reproductive technologies were left out of the legislation by the sponsor's design. Thus the debate had a decidedly more regulatory flavor. The paper places these results in an epidemiological framework and illustrates how qualitative investigation of the characteristics of policies, when conceived of as viruses, and of policy entrepreneurs and interest groups, when conceived of as vectors, can aid our understanding of policy diffusion.


The quaternary system Al e Fe e Si e Ti was studied in the iron-rich corner for sections at 50, 60 and 70 at.% Fe at 900 (cid:1) C. Isothermal phase equilibria were investigated by a combination of optical microscopy, X-ray powder diffraction (XRD) followed by Rietveld re fi nement and Electron Probe Microanalysis (EPMA). Phase boundaries of the phases, in particular of the Laves phase (Fe 2 Ti) and of the extended phase fi eld of A2/B2/D0 3 , were investigated. Selected samples containing the Laves phase and the B2 phase were characterized by microhardness measurements at different compositions throughout the quaternary homogeneity range of the phases.


Distal sesamoidean ligament (DSL) injury is a recognized cause of lameness in horses. The purpose of this study was to describe the contrast-enhanced computer tomography (CE-CT) findings in horses with injury to the DSL compared to a control group without injury to the DSL. Medical records of horses referred for CE-CT between 2008 and 2015 were reviewed. Cases were selected retrospectively based on a CE-CT imaging finding of injury to the DSL. Three horses had DSL injury as the only finding, while the remaining horses had one or more concomitant injuries. DSL injury and fetlock trauma and/or suspensory branch desmitis were the most frequent injury combinations. CE-CT can be of value in diagnosing DSL injury. The high number of concurrent DSL and fetlock and/or suspensory lesions suggests that further investigation should be considered when evaluating horses with injuries related to either of these structures.


The techniques for soil sample pretreatment,such ultrasonic extraction and water bath extraction as microwave-assisted extraction were comparatively studied for inorganic arsenic in the standard substances of national level soil by HG-AFS.The influencing factors of solvent,extraction time,and the volume of extraction solvent on the efficiency were discussed.Compared with the ultrasonic extraction and water bath extraction method,the microwave-assisted extraction was time saving and more efficient.


Production of seed cones from 1978 to 1987 and of pollen cones from 1980 to 1982 by young black spruce (Piceamariana (Mill.) B.S.P.) trees was recorded in five plantations aged 8, 10, 12, 14, and 16 years in 1980. Variations in cone production and percentages of trees bearing cones were assessed in relation to changing tree age and cone numbers per tree. The first seed cones and pollen cones were noted on 7- and 10-year-old trees, respectively. After ages 10–12 for seed cones and 12–14 for pollen cones there were substantial yearly fluctuations of average numbers of cones per tree. Similarly, the percentages of trees bearing cones fluctuated among years, but differences between poorer and better years decreased as the proportion of bearing trees gradually increased. Up to age 14, the number of seed cones borne per tree was generally higher than the number of pollen cones. Thereafter, pollen-cone production was always higher than seed-cone production and reached 6.6 pollen cones per seed cone by age 18. Po...


The purpose of this study was three fold: (1) to reveal the implications of Wnt5A for cytokine and chemokine production by human ovarian cancer cell line SKOV‐3 cells, (2) to determine the influence of Wnt5A on chemotactic SKOV‐3 cell migration, and (3) to assess the effect of inflammatory mediators on Wnt5A expression levels and to describe its underlying molecular mechanisms. A cytokine array was performed using a conditioned medium harvested from SKOV‐3 cells transfected with specific siRNAs against Wnt5A or with scrambled siRNA and a transfection reagent alone as negative controls for 48 h. Chemotactic cell migration was performed using transwells. Inflammation‐induced Wnt5A expression was determined by treating cells with recombinant human (rh) IL‐1β, IFNβ, or TNFα alone or in combination with STAT3 and NF‐κB inhibitors for different time durations. The cytokine array showed the suppression of GCSF, GM‐CSF, IL‐1α, IL‐2, IL‐13, and MCP‐3 production, whereas cell RANTES and IL‐7 showed increased levels in Wnt5A knock‐down cells compared with those in controls. Chemotactic migration decreased significantly when the conditioned medium from Wnt5A knock‐down cells was applied to the upper chamber of the transwell. Compared with the control, there were 30‐fold and five‐fold increases in Wnt5A mRNA levels in cells treated, with rhIL‐1β and rhIFNβ, respectively after 8 h (P < 0.001). Compared with the control, TNF‐α had a 1.8‐fold increased levels of Wnt5A mRNA after 4 h (P < 0.01). Both NF‐κB and STAT3 inhibitors decreased inflammation‐induced Wnt5A expression. This study revealed a previously unrecognized immunomodulatory role of endogenous Wnt5A in ovarian cancer cells, which could further influence chemotactic cell migration.


The first neutron diffraction results obtained on single crystals of HoMo 6 S 8 are reported. At temperatures below T m =0.65 K, HoMo 6 S 8 develops a magnetic ordering of long period; the magnetic moments, aligned along the [111] direction, are perpendicular to the modulation wave vector k=[k, − k, 0] (rhombohedral cell). This modulated phase can be quenched at T=0.1 K (k=0.008). However, by slow cooling, the modulated phase transforms into a ferromagnetic ordering with microdomains of size 1000 A to 1500 A Presence d'un ordre magnetique a longue periode a T m <0,65 K, avec des moments magnetiques alignes selon la direction [111] et perpendiculaires au vecteur d'onde de la modulation k=[k, − k, 0] (maille rhomboedrique). Trempe de cette phase modulee a 0,1 K, mais formation d'une phase a ordre ferromagnetique avec microdomaines de dimension 1000-1500 A par refroidissement lent


A major virtue of Herbert Tucker's essay, "Browning's Lyric Intentions,"' is that it invests the reading of Browning with a question that naturally inflames critical passions: What does it mean to interpret a text? Tucker shows that one can learn a number of important things about this matter by studying Browning, that is, by studying interpretation in the midst of its active complications. Tucker is right to characterize Browning as a poet who gave the notion of intentionality a second thought and who grew mildly obsessed with it. We know this obsession intimately. The idea of intention seems truly indispensable to any theory of interpretation; yet it is precisely this idea that confounds hermeneutics, not only because it is in its own right a historically contingent idea--it is a chief category of Romantic hermeneutics--but also because intention is that which history always manages to obscpure or erase. The paradox is that the logic of hermeneutics requires an idea on which history confers every honor but the right of subsistence. Tucker's subject, of course, is lyric intentionality. He says that "intentionality [is] inherent in the [lyric] genre," but surely this is true mainly


San Vicente de1 Rio emerges in the high Andean mists, visible for more than a half-hour before arrival there over a trail that became a road cut precariously into the mountainside only a few years ago (Fig. 1). Our journey to San Vicente began when the authors first met in Quito, when A.R. went there in December 1988 to follow up several GH-treated patients he had been seeing in Florida. We were unaware of the adventure before us when we met and decided to work together. Six months later, in June 1989, we saw six adult women and a toddler from southern Ecuador with severe short stature, harbingers of a population that would eventually involve nearly one-third of the worlds known cases of Laron syndrome [GH insensitivity due to GH receptor deficiency (GHRD)]. On our first investigative trip south, in December 1989, we met the great-grandmother of three affected sisters (Fig. 2) and explained our mission while waiting for the rest of the family to return from market in a neighboring town. At the time, we did not know that we would be able to identify the genetic defect or provide specific therapy [recombinant insulin-like growth factor I (IGF-I)]. We did know that we would be able to help them understand the condition and, after hearing of our interest, this 88-yr-old woman extended her hand and said, "Bienvenidos a mi tierra de soledad" (Welcome to my land of solitude). Not only did she acknowledge the sincerity of our mission, but she recognized the social circumstances that generated the problem. Thus did we come to San Vicente, home or origin of a dozen affected individuals. How did the people of San Vicente come there? There is no legend. They have always been there. The matriarch answers, "When I opened my eyes, it was here." Those who have not been to school have no concept of what the name Spain means. Their voyage to San Vicente and the other foci of GHRD in the area 120 km in diameter in southern Ecuador that encompasses the origins of all affected individuals began with the cataclysmic events in Spain in 1492. On March 31 of that year, King Ferdinand and Queen Isabella issued the Edict of Expulsion to the Jews,


Objective To increase the solubility of furacilin by preparing its solid dispersion.Methods Different solid dispersion of furacillin were prepared by using the melting method and solvent-melting method,with polyethylene glycol 6000 (PEG) as a carrier.The ratio of drug and carrier was 1:3,1:6,and 1:9 repectively.In vitro dissolution and solubility tests were compared between the original drug and furacilin solid dispersions.Results The in vitro dissolution and solubility of furacilin solid dispersion was significantly increased comparing with the original drug.Conclusion The dissolution of furacilin can be improved by mixing furacilin and polyethylene glycol (PEG)-6000 in a ratio of 1:6 in solvent–melting method.


The bearing reinforcement was regarded as a cost-effective earth reinforcement. A numerical simulation of the bearing reinforcement earth wall by PLAXIS 2D is presented in this paper. The change in bearing stresses, settlements and tensions in the reinforcements during and after construction is simulated. Overall, the simulated test results are in good agreement with the measured ones. The simulated results show that the BRE wall behaves as a rigid body, retaining the unreinforced backfill. The simulated bearing stress presents a trapezoid distribution shape as generally assumed by the conventional method of examination of the external stability of mechanically stabilized earth walls. The simulated settlement is almost uniform due to a high stiffness of the rigid foundation and the bearing reinforcements. The maximum tension (possible failure) plane is bi-liner, which is typical for inextensible reinforcements. The knowledge gained from this study can be applied to other BRE walls with different wall heights, foundations and features of bearing reinforcements.


This article is about the existing problems in the development of China's pension industry and the future trend of the speculation. By selecting the objects of different age groups and using the methods of literature, questionnaires and interviews, the paper analyzes the current situation of aging population, at the same time it discusses the new needs of the aged care industry and contrasts the development model of the elderly care in China and foreign countries so as to promote the continuous improvement of the aged care industry in our


There are numerous stochastic models for cancer risk for a given tissue. Many rely on the following two hypotheses. 1. There is a fixed probability that a given cell division will eventually lead to a cancerous cell. 2. Cell divisions are nefarious or not independently of each other. We show that recent data on cancer risk and number of stem divisions is consistent with hypotheses 1 and 2.


Objective: The purpose of this study was to observe and evaluate the possible complications of Transoral Endona-sal-Controlled Combined Endoscopic Adenoidectomy (TECCA) as a subtype of power-assisted endoscopic adenoidectomy (PAEA) in pediatric patients. Methods: Sixty-seven children aged between 2 and 12 years who had been diagnosed with adenoid hypertrophy and underwent TECCA from April 2013 to December 2016 as a single procedure (without myringotomy or any kind of tonsil surgery at the same time) were included. Preoperative risk assessment results and intraoperative and post-operative complications were evaluated. Results: Intraoperative and early post-operative bleeding was observed in four (5.97%) patients. There was no post-operative complication except for bleeding and no patients were found to have residual adenoid tissue during the six-month post-operative follow-up period. Conclusion: Endonasal endoscopic control during adenoidectomy helps to identify vascular structures that would normally be at risk of being injured with blind resection. Endoscopic viewing also enables complete removal of intranasal adenoid tissue without significant prolongation in operation time.


Nematodes are the most frequently encountered organisms on the earth and face some adverse conditions in their habitats resulting in death. They can survive different habitats by revealing the various adaptations provided by some abilities and behaviours accompanying the abilities. The faced problems are withstanded as morphological, physiological, biochemical and molecular responses enabling them to survive. This review focused on resistance adaptation and facultative quiescence stages related to the adaptation.


The synthetic aperture radar (SAR), as a wideband radar system, operates over a large frequency band ranging from the low very high frequency to millimeter waves. It often overlaps in frequency with other radio-frequency systems including radio, television, and cellular networks. Therefore, radio-frequency interference (RFI) suppression is the severe test for SAR systems. Recently, some methods are proposed to suppress the RFI based on the sparse recovery in range-frequency domain and low-rank extraction in the azimuth dimension. However, all the previous methods exploit one property of the RFI, which may leave the room for performance improvement. Hence, in this paper, we propose three methods to jointly exploit the sparsity and low-rank property of RFI. We first include the sparse term and low-rank term of the RFI in the objective function to separate the RFI and the useful signal, which is defined as the joint sparsity and low-rank property method. It has better performance but heavier computational burden than the algorithm employing only the low-rank property. Then, we use row-sparse (RS) concept in lieu of the two properties, since the narrowband RFI has relatively stable frequencies during the synthetic aperture time. The RS method avoids the low-rank optimization and dramatically decrease the computational burden. Also for the real radar system, the sampling frequency is commonly larger than the frequency bandwidth. Therefore, there are some redundant data in the received signal. We exploit both the downsampling operation and the RS concept to speed up the convergence, which is called the fast row-sparse (FRS) method. The FRS method can further eliminate the out-of-mainband RFI. The real SAR data are provided to demonstrate the effectiveness of the three proposed methods.


AN ACT to amend 1949 PA 300, entitled "An act to provide for the registration, titling, sale, transfer, and regulation of certain vehicles operated upon the public highways of this state or any other place open to the general public or generally accessible to motor vehicles and distressed vehicles; to provide for the licensing of dealers; to provide for the examination, licensing, and control of operators and chauffeurs; to provide for the giving of proof of financial responsibility and security by owners and operators of vehicles; to provide for the imposition, levy, and collection of specific taxes on vehicles, and the levy and collection of sales and use taxes, license fees, and permit fees; to provide for the regulation and use of streets and highways; to create certain funds; to provide penalties and sanctions for a violation of this act; to provide for civil liability of owners and operators of vehicles and service of process on residents and nonresidents; to provide for the levy of certain assessments; to provide for the enforcement of this act; to provide for the creation of and to prescribe the powers and duties of certain state and local agencies; to impose liability upon the state or local agencies; to provide appropriations for certain purposes; to repeal all other acts or parts of acts inconsistent with this act or contrary to this act; and to repeal certain parts of this act on a specific date," by amending sections 307 and 310 (MCL 257.307 and 257.310), as amended by 2008 PA 7. The People of the State of Michigan enact: Sec. 307. (1) If an applicant for an operator's license or chauffeur's license is a citizen of the United States, the applicant shall supply a photographic identity document, a birth certificate, or other sufficient documents as the secretary of state may require to verify the identity and citizenship of the applicant. If an applicant for an operator's or chauffeur's license is not a citizen of the United States, the applicant shall supply a photographic identity document and other sufficient documents to verify the identity of the applicant and the applicant's legal presence in the United States under subdivision (b). The documents required under this subsection shall include the applicant's full legal name, date of birth, and address and residency and demonstrate that the applicant is a citizen of the United States or is legally present in the United States. If the applicant's full legal name differs from the name of the applicant that appears on a document presented under this subsection, the applicant shall present documents to verify his or her current full legal name. An application for an operator's or chauffeur's license shall be made in a manner prescribed by the secretary of state and shall contain all of the following: (a) The applicant's full legal name, date of birth, residence address, height, sex, eye color, signature, intent to make an anatomical gift, other information required or permitted on the license under this chapter, and, only to the extent required to comply with federal law, the applicant's social security number. The applicant may provide a mailing address if the applicant receives mail at an address different from his or her residence address.


In the past few years,nanomaterials have been widely researched and used.Applying nanomaterials for the biosensors will greatly improve the performance of the resulting biosensor.Carbon nanotubes(CNTs)due to their unique one-dimenoional structures provide a wider prospect for the development of biosensor.In this paper,the progress in research on CNTs modified electrochemical biosensors is reviewed in past a few years.Different fabrications of the enzyme biosensors,DNA biosensor and immunosensor based on the CNTs are evaluated with their advantages and disadvantages.Finally,the progressive directions of the CNTs modified biosensor are also prospected.


Summary A key concept underpinning most safety assessments of geological disposal systems for high-level nuclear wastes is that the maximum aqueous concentrations of actinide elements released from the waste will be limited by the solubility of the corresponding tetravalent oxide or hydrous oxide. The validity of this concept for U is evaluated in the present study using hydrochemical and mineralogical data from the Tono uranium (U) deposit in Gifu Prefecture, Japan. In addition, the long-term stability of U mineralization in the Tono deposit is assessed in terms of plausible range of U solubilities in paleogroundwaters migrating through the deposit. A thermodynamic evaluation of the aqueous-speciation and solubility behaviour of U indicates that U concentrations in the coexisting groundwaters greatly exceed the solubility of both uraninite [UO2(c)] and coffinite [USiO4(c)]. The dissolved U concentrations appear instead to be controlled by the solubility of amorphous hydrous U(IV) oxide [UO2(am)], which is metastable with respect to uraninite. Mineralogical and microbiological investigations suggest that pH–Eh conditions similar to those observed presently in groundwaters of the lower Toki Lignite-bearing Formation (pH≈8-10; Eh≈-250--410 mV) have been buffered, possibly since the present geological structure formed about 5-0.7 Ma, by microbial sulphate reduction and precipitation/dissolution of calcite. If so, corresponding U concentrations controlled by UO2(am) solubility are calculated to have been in the range of 10-6.1 and 10-8.7 mol kg-1 depending on the possible environmental conditions, i.e., Eh, pH and carbonate concentration.


This article describes the development of an instrument – the Career and Talent Development Self‐Efficacy Scale (CTD‐SES) – for assessing students' self‐efficacy in applying life skills essential for personal talent development, acquisition of positive work habits, and career exploration. In Study 1, data were obtained from a large sample of Chinese middle‐school students (N=15,113) in Grades 7–9 in Hong Kong. The CTD‐SES is an 18‐item questionnaire with subscales containing items that address students' orientations toward developing their own talents, acquiring and applying positive work habits, and exploring their career possibilities. Evidence is provided for internal consistency, temporal stability, and factor structure of the CTD‐SES. Goodness of fit statistics provided support for a three‐primary‐factor‐plus‐higher‐factor model, and this solution was used in the statistical analyses. The data also indicated that students with plans for university study reported significantly higher scores than those without on all three domains of career and talent development. In Study 2 (N=308) Grade 10 high‐ability students' scores in CTD‐SES were correlated with scores in career decision self‐efficacy and academic performance. The development and validation of CTD‐SES is the first step toward investigating career exploration, work habits, and talent development among Asian middle‐school adolescents.


PURPOSE: To execute fast augent matrix reducing arithmetic by using few hardwares and wires and many half adders. CONSTITUTION: A multiplier circuit 100 receives a multiplier and a multiplicand to generate matrix-made five rows and ten columns. Then columns 1 to 3 are reduced to be 2 or 1 bit at a level I. At a level II, a half adder 112 generates the bit of a sum with respect to a column 4 and a carry bit with respect to a column 5. A total adder 114 generates a sum bit with respect to the column 5 and a carry bit with respect to a column 6. A total adder 116 generates a sum bit with respect to the column 6 and a carry bit with respect to a column 7. A total adder 117 generates a sum bit with respect to a column 8 and a carry bit with respect to a column 9. At a level III, a half adder 118 generates a sum bit with respect to the column 6 and a carry bit with respect to the column 7. A total adder 120 generates a sum bit with respect to the column 7 and a carry bit with respect to the column 8. COPYRIGHT: (C)1989,JPO


The title compound 4, i.e. 9-chloro-4,5-dihydro-2-ethyl-1-(2,4,6-trichlorophenyl)-1H-1,2,4-triazolo[3,2-d]-[1,5]benzoxazepinium hexachloroantimonate, is a novel 6-7-5 tricyclic heterocycle. C18H14Cl4N3O·SbCJ6, M = 764.61, P21/c(#14), a = 13.457(4), b = 11.583(2), c = 18.992(3) A α = 90, β = 110.11(1)°, Z = 4, V = 2780(1) A3, Dc = 1.827 g/cc, μ (MoKα) = 19.69 cm−1, F(000) = 1488.00, T = 293 K, Rint = 0.055 for 3094 independent reflections with I>3.00σ(I). The five-membered heterocyclic ring is nearly planar, with the trichlorophenyl ring at N(2) almost perpendicular to it. However, the seven-membered ring is not planar, but adopts a twist-boat conformation.


Network simulation method is one of the important methods to study the performance of TSN . However, different methods have different characteristics in the study of TSN. Therefore, before carrying out the research on the performance of TSN, it is particularly important for researchers to choose the appropriate simulation method. In this paper, firstly, the main network simulation methods are summarized, and the requirements of simulation methods for TSN performance research are analyzed. Finally, the adaptability of different network simulation methods for TSN performance research is obtained. The evaluation results provide a reference for the proper selection of simulation methods in the study of TSN performance.


Hydraulics research has monitored the design and performance of irrigation off takes for three wadi systems (Rima, Zabid and Mawr) in the Yemen Arab Republic. This paper is drawn from the experience gained during these projeets, and from research into improved design methods for sediment control structures.
The wadis thatcross the Yemen coastal plain (Tihama) have steep, (0.5 to 1 percent) bedslopes.and flow inaseries of multipeaked flash floods. Discharges can rise to more than 1 000 m'/s. returning to less Jtan 1 m'ls in 4 to 10 hours, and stream velocities can exceed 4 m3/s (Lawrence 1982).


Building a new socialist countryside is a major task in China,and rural tourism development will promote the building of new socialist countryside.As a new point of economic growth,rural tourism development should be done well with scientific planning,characteristic development,farmers' participation,government's support and normal management.which will help to solve the problems of jobs and earnings for farmers,raise the quality of farmers,foster more civilized behavior,and build a new socialist countryside.


The processing method of a semiconductor substrate which can be made constant regardless of the contamination of the chamber processing a semiconductor substrate is provided. According to the treatment method of semiconductor substrate according to the present invention, measuring the contamination of the chamber, and receiving feedback of contamination of the chamber is contaminated on the process conditions for processing each of the semiconductor substrate prior to processing each of the semiconductor substrate, You can change the process conditions so as to offset the impact. Accordingly, increasing the reliability for the semiconductor process, it can be improved and the yield of the product.


The formation and growth of supermassive black holes is a key issue to unveil the secrets of galaxy formation. In particular, the gravitational recoil produced in the merger of unequal mass black hole binaries could have a number of astrophysical implications, such as the ejection of black holes from the host galaxy or globular cluster. We present estimates of the recoil velocity that include the effect of small eccentricities. The approach is especially suited for the last stage of the merger, where most of the emission of linear momentum in gravitational waves takes place. Supplementing our estimates with post-Newtonian approximations, we obtain lower and upper bounds that constrain previous recoil velocities estimates, as well as a best estimate that agrees with numerical simulations in the quasi-circular case. For eccentricities e ≤ 0.1, the maximum recoil is found for a mass ratio of M1/M2 ~ 0.38 with velocities in the range 79-216 km s-1 (1 + e) and a best estimate of 167 km s-1 (1 + e).


Principles of evidence theory are used to develop a methodology for quantifying epistemic uncertainty in constitutive models that are often used in nonlinear finite element analysis involving large plastic deformation at different strain rates and temperatures. The developed methodology is used for modeling epistemic uncertainty in Johnson-Cook plasticity model. All sources of uncertainty emanating from experimental stress-strain curves for different temperatures and strain rates, as well as expert opinions for method of fitting the model constants and the representation of homologous temperature in the model are considered. The five Johnson-Cook model constants are determined in interval form using two different fitting approaches and three sets of experimental data. Rules for identifying intervals that are in agreement, conflict, or ignorance are discussed. The presented methodology is used to find the basic belief assignment (BBA) for separate intervals of uncertainty, and the Yager rule is used for combining different sources of evidence and generating a consolidated BBA structure for each model constant. The represented uncertainty intervals with corresponding BBA are used to estimate belief and plausibility of precision intervals for a published set of Johnson-Cook constants for Al6061-T6. Results show that the constants of Johnson-Cook plasticity model are subject to considerable uncertainty.


P-odd effects in the process ..pi../sup +/p..--> pi../sup +/p..gamma.. in the region below the ..pi..-meson production threshold are studied. It is found that the asymmetry of the photon emission relative to the polarization vector of the initial proton is determined by the interference of the amplitudes of the dominant E2 transition and the E1 transition induced by P-odd admixtures in the ..pi..p wave function in the initial and final states. The asymmetry coefficient is ..cap alpha..approx. ..D/sub 33/. The other P-odd correlation: the circular polarization P/sub ..gamma../ of the bremsstrahlung photon emitted in the scattering of a ..pi.. meson on an unpolarized proton: is determined by the interference of the amplitudes of the dominant electric transition and the magnetic-type transition, which causes P/sub ..gamma../ to contain an additional (compared to ..cap alpha..) suppression factor ..omega../k<<1.


This investigation is focused on the conversion of waste plastic into modified pavement interlock block (Bitumen: quarry dust: coarse aggregate: rice straw ash: waste plastic:: 5% by weight of aggregate mix : 1:2:2% by weight of aggregate mix : 8% by weight of Bitumen) for Mathura Vrindavan city. The aim of this work is to reduce the rapid accumulation of waste plastic at religious places/ tourist spot by throwing the PET bottles in Mathura Vrindavan city. With the application of these experimental results, can make economical and environment friendly paving block. For each 6.7 no. of paving block, 1 PET bottle (38gm) of 1lit volume consumed hence in 10m2 areas 55.37no. bottles can be utilized. From Marshall Stability- Flow value test, 8% of PET plastic is optimum value which can use in manufacturing of modified paving block with 80/100 grade of bitumen. The average compressive strength of these blocks at 3 and 7 days is15.94MPa and 24.2MPa and the water absorption value is approximately 0.27%. In the presence of sodium sulphate (250gm in 1lit water) loss of weight is around 7.7%. It was estimated that the manufacturing cost of designed paving block is 12Rs. whereas concrete paving block of same size is Rs. 17. Hence its cost quite low as compared to conventional block. Keywords- Mathurav vrindavan city, waste plastic, Bitumen


In this dissertation, we discuss the generation of low discrepancy sequences, randomization of these sequences, and the transformation methods to generate normally distributed random variables. Two well known methods for generating normally distributed numbers are considered, namely; Box-Muller and inverse transformation methods. Some researchers and financial engineers have claimed that it is incorrect to use the Box-Muller method with lowdiscrepancy sequences, and instead, the inverse transformation method should be used. We investigate the sensitivity of various computational finance problems with respect to different normal transformation methods. Box-Muller transformation method is theoretically justified in the context of the quasi-Monte Carlo by showing that the same error bounds apply for Box-Muller transformed point sets. Furthermore, new error bounds are derived for financial derivative pricing problems and for an isotropic integration problem where the integrand is a function of the Euclidean norm. Theoretical results are derived for financial derivative pricing problems; such as European call, Asian geometric, and Binary options with a convergence rate of O(N−1). A stratified Box-Muller algorithm is introduced as an alternative to BoxMuller and inverse transformation methods, and new numerical evidence is presented in favor of this method. Finally, a statistical test for pseudorandom numbers is adapted for measuring the uniformity of transformed low discrepancy sequences.


The effects of error fields at a shell gap are measured both optically and magnetically in a Reversed Field Pinch experiment. The measurements show that the increase of poloidal flux consumption is caused by the error fields in the start up phase of discharge. The vertical components of error fields drive the plasma column to the tube wall. In large error fields, the plasma column touches the wall and the plasma current decays quickly.


The aim of clinical drug trials is to select the therapeuticalIy most useful preparations from pharmacologycally effective substances. The most therapeutically useful preparations are those that are most beneficial for the patient and for his surroundings, in addition to being most effective acutely in the treatment of the disease. Proving the efficacy of a drug by controlled clinical trials is an early step along the long road towards the goal of drug development, and the type of documentation required in the last part of phase 2 in clinical trials is an important factor for deciding whether or not to proceed with further studies on a drug.


Software cost estimation is one of the most challenging activities in software project management. Since the software cost estimation affects almost all activities of software project development such as: biding, planning, and budgeting, the accurate estimation is very crucial to the success of software project management. However, due to the inherent uncertainties in the estimation process and other factors, the accurate estimates are often obtained with great difficulties. Therefore, it is safer to generate interval based estimates with a certain probability over them. In the literature, many approaches have been proposed for interval estimation. In this study, we propose a navel method namely Analogy Based Sampling (ABS) and compare ABS against the well established Bootstrapped Analogy Based Estimation (BABE) which is the only existing variant of analogy based method with the capability to generate interval predictions. The results and comparisons show that ABS could improve the performance of BABE with much higher efficiencies and more accurate interval predictions.


The aim of this paper is to contribute to machine-learning technology that expands real-time and offline Integrated System Health Management capabilities for future deep-space exploration efforts. To this end, we have developed Anomaly Detection via Topological feature-Map (ADTM), which leverages a Self-Organizing Map (SOM)-based architecture to produce high-resolution clusters of nominal system behavior. What distinguishes ADTM from more common clustering techniques (e.g. k-means) is that it maps high-dimensional input vectors to a 2D grid while preserving the topology of the original dataset. The result is a 'semantic map' that serves as a powerful tool for uncovering latent relationships between features of the incoming data points. We successfully modeled and analyzed datasets from a NASA Ames Research Center Graywater Recycling System which documents a real hardware system fault. Our results show that ADTM effectively detects both known and unknown anomalies and identifies the correlated measurands from models trained using just nominal data.


The NOAA-led U.S. Integrated Ocean Observing System (IOOS) and the National Science Foundation's Ocean Observatories Initiative (OOI) have been collaborating since 2007 on advanced tools and technologies that ensure open access to ocean observations and models. Initial collaboration focused on serving ocean data via cloud computing - a key component of the OOI cyberinfrastructure (CI) architecture. As the OOI transitioned from planning to execution in the Fall of 2009, an OOI/IOOS team developed a customer-based "use case" to align more closely with the emerging objectives of OOI-CI team's first software release scheduled for Summer 2011 and provide a quantitative capacity for stress-testing these tools and protocols. A requirements process was initiated with coastal modelers, focusing on improved workflows to deliver ocean observation data. Accomplishments to date include the documentation and assessment of scientific workflows for two "early adopter" modeling teams from IOOS Regional partners (Rutgers - the State University of New Jersey and University of Hawaii's School of Ocean and Earth Science and Technology) to enable full understanding of data sources and needs; generation of all-inclusive lists of the data sets required and those obtainable through IOOS; a more complete understanding of areas where IOOS can expand data access capabilities to better serve the needs of the modeling community; and development of "data set agents" (software) to facilitate data acquisition from numerous data providers and conversions of the data format to the OOI-CI canonical form.


Multicast is a bandwidth-efficient mechanism to provide wireless services for a group of terminals. Providing reliable wireless multicast is challenging due to packet loss and channel fading. In this research, we investigate the medium-access-control (MAC) layer cooperation to enhance the reliability of wireless multicast. We show that the optimal relaying strategy is a pure threshold policy, i.e., the optimal number of relays is bounded by a threshold. We also propose a simple and efficient algorithm to find the optimal time allocation for the direct and relay transmissions.


22110 Background: Preliminary results from the National Surgical Adjuvant Breast and Bowel (NSABP) adjuvant trastuzumab breast cancer (BC) trial, B-31, suggested that HER2-positive BC patients with...


Along with the government's policy to convert from kerosene to LPG gas, LPG consumer demand is increasing. It requires the LPG distributors to be able to meet the needs of its customers. PT. Limas Raga Inti is an authorized distributor company PT. Pertamina LPG product devoted to distribute 12 kg. The company's main commitment is to provide the best service to the consumer. One of the efforts to improve the quality of service is to provide optimization of the distribution process. Optimization can be done by determining the distribution of the matrix saving method to obtain the optimal route. The purpose of the optimization of route determination is to provide effectiveness and efficiency of the distribution process. Effectiveness and efficiency can be seen with the speed of delivery time and can overcome the problems that exist in the company. In the process of determining the route to saving matrix, is done in the consumer sorting method which has produced the nearest neighbor and nearest the insert. Then do the repair method using 2-opt and or-opt in order to provide the best route to the selected proposal. Furthermore, the delivery time will be calculated based on the productivity of the proposal and indicating the optimal route. The results of this study are are 4 routes proposed by sorting nearest neighbor method with a total delivery time of 10 hours 30 minutes for 100 customers spread in the distribution area D14. The resulting productivity by 85.11%.


The crystal structure of the title compound, C68H60N16O5Fe2, shows a dinuclear complex of two crystallographically independent, distorted hemiporphrazinato iron complexes with five-coordinate iron and oxygen as bridging ligand. The Fe1-O1-Fe2 angle is 151.16°, the Fe-O bond lengths are Fe1-O1 [1.771(2) A] and Fe2-O1 [1.773(2) A]. The dinuclear complexes have a staggered conformation with a dihedral angle of 26.2°, but coaxially to form tetrameric units is not observed. The molecule is characterized by short Fe-N (isoindole) bonds [1.998(3) A] and long Fe-N (pyridine) bonds, values range from [2.175(3) A] to [2.245(3) A].


Condensation of quaternary 2-methylbenzothiazolium bromides with 5-(dialkylamino)furan-2-carbaldehydes afforded a series of new thiacyanine analogs. The compounds exhibit significant activities against several bacterial, yeast, and mould strains. Derivatives with dipropylamino substituents showed higher inhibitory effects than those with cyclic secondary amino groups. Hence, the biological activity may have been influenced by the lipophilicity of the compounds. The effect on growth and on the plastid system of the unicellular flagellate Euglena gracilis was also studied.


Objective To investigate the CT features of seminal vesicles in middleage and aged man in Jiangsu district.Methods CT features of the seminal vesicles in 153 males aged 50-93 years old were analyzed.Results The shape of the seminal vesicles was varied with the mean length of(4.50±0.50) cm and the mean thickness of(1.70±0.50) cm.The differences in sizes or corrected values among different age groups were not significant(P0.05).The differences of mean thickness and its corrected value among different shape groups were statistically significant(P0.01),which were not in the length of the seminal vesicles(P0.05).The corrected length of the vesicles was longer in the cases with benign prostatic hyperplasia(BPH) than that in those with normal prostate(P0.05).The mean thickness and its corrected value were greater in BPH cases than those in those with normal prostate(P0.05).Conclusion The size of the seminal vesicle is related with the age,shape of the vesicle and degree of prostatic hypertrophy.The results of seminal vesicle measurements should be corrected with the size of pelvic cavity for making a suitable evaluation about the size of the seminal vesicle.


In an important paper contributed several years ago to this Journal1 Dr. Tarn presented an interpretation of the Battle of Actium radically different from that which had held the field for the past generation—namely that of the late Professor Kromayer. The paper was brilliantly and authoritatively written, and its chief conclusions appear to have been accepted by some scholars. They were subsequently embodied by Tarn in his section on Actium in the Cambridge Ancient History. Kromayer, however, was unconvinced, and in a reply published in Hermes maintained his original thesis and strongly criticised Tarn's. It seems presumptuous to enter the lists after the veteran scholar has made his own defence; but the question is an important one, and something perhaps remains to be said.


The invention relates to a method for bleaching broadleaf wood pre-conditioning refiner chemical pretreatment alkaline peroxide mechanical pulp (P-RC APMP) by using H2O2/an optical brightening agent (OBA), and provides an economically feasible method for bleaching the broadleaf wood P-RC APMP by using hydrogen peroxide and the OBA as bleaching agents. By the novel method for bleaching high yield pulp, an appropriate type of OBA is selected and added into an appropriate position (a blow pipe) of a pulping and bleaching process pipeline for the broadleaf wood P-RC APMP, so that the optical properties (brightness and brightness stability) of the high yield pulp are improved, and the production cost of the high yield pulp is reduced.


Inflammatory bowel disease (IBD), which includes ulcerative colitis (UC) and Crohn's disease (CD), represents a constellation of autoimmune disorders that affect the entire gastrointestinal tract1. The incidence and prevalence of IBD is continuously increasing in different parts of the world, with an estimated ~1.5 million people affected by these two diseases in the United States alone2. Patients with IBD present with an increased risk for developing colorectal cancer (CRC)3, with the relative risks for developing this malignancy about 5.6 and 30 times in patients with CD4 and UC5 respectively, in comparison to the general population. Risk factors for colitis-associated cancer (CAC) include disease duration of >8 years, and presence of pancolitis, colonic dysplasia, and primary sclerosing cholangitis affecting liver1. While moderate to severe UC can be treated with antibody-based treatments with some success, limited options exist for treating patients with mild to moderate UC that don't respond to mesalamine, underscoring the need for development of safer and robust treatment options designed for abating chronic inflammation and continuous disease activity in the colon.


Parent material is an important factor in soil formation, especially in soils formed in Mediterranean region dominated by calcareous sedimentary rocks. Their basic properties (mineralogical composition, coherence, and permeability for water) influence the resistance to weathering and type of weathering products, its amount, particle size distribution, as well as the intensity of physicochemical transformations within the original rock residue. Thus, the aim of this study was to investigate the impact of parent material on soil properties in southern part of Krka National Park, Croatia. Weathering of carbonate parent material (limestones, dolomites, conglomerates, marls) along with other soil forming factors was the base for soil development in this area. Thus, Calcocambisols and Terra rossa, typical and ilimerized are the most widespread soil types, while Calcomelanosols, Colluvium and Rendzinas are as well represented, but in much lesser extent. Soil depth, presence of coarse fragments and carbonate content in these soils vary considerably depending on parent material, although factors such as relief, vegetation and anthropogenic impact cannot be neglected. In general, shallow soils ( 35 cm) were formed on limestones and conglomerates, while medium deep soils (35-70 cm) were formed on marly substrates. The content of coarse fragments of variable size in soils (fine gravel 2-6 mm to boulders 60-200 cm) is related to different weathering processes of parent material. The presence of carbonate nodules on soil surface and within soil profile also indicates pedogenetic processes related to different types of carbonate parent material.


In order to increase the accommodation rate of renewable energy and cut the system operation cost, this paper takes "source-load-energy storage" coordination as an important mean to improve the system operation economy and the accommodation rate of renewable energy. Then, an optimization dispatch model based on "source-load-energy storage" coordination which considers thermal units, energy storage device and demand response as dispatching resources is established. The objective of this model including the operation costs of thermal units, the costs of demand response and the benefits from renewable energy consumption. Based on the different characteristics of the decision variables, a two-stage optimal algorithm is proposed. The first stage algorithm uses binary particle swarm optimization algorithm to minimize the start costs of thermal units, costs of wind power and photovoltaic curtailment and costs of demand response; the second stage uses double layer continuous particle swarm optimization algorithm to minimize the fuel costs of thermal units. The simulation results verify the validity of the proposed optimization dispatch strategy.


With the development of high energy physics experiments, a large amount of exotic states in the hadronic sector have been observed. In order to shed some light on the nature of the tetraquark and pentaquark candidates, a constituent quark model, along with the Gaussian expansion method, has been employed systematically in real- and complex-range investigations. We review herein the double- and fully-heavy tetraquarks, but also the hidden-charm, hidden-bottom and doubly charmed pentaquarks. Several exotic hadrons observed experimentally were well reproduced within our approach; moreover, their possible compositeness and other properties, such as their decay widths and general patterns in the spectrum, are analyzed. Besides, we report also some theoretical predictions of tetra- and penta-quark states which have not seen by experiment yet.


Abstract In the past years, Pd0‐catalyzed C(sp3)−H activation provided efficient and step‐economical methods to synthesize carbo‐ and heterocycles via direct C(sp2)−C(sp3) bond formation. We report herein that a 1,4‐Pd shift allows access to N‐heterocycles which are difficult to build via a direct reaction. It is shown that o‐bromo‐N‐methylanilines undergo a 1,4‐Pd shift at the N‐methyl group, followed by intramolecular trapping by C(sp2)−H or C(sp3)−H activation at another nitrogen substituent and remote C−C bond formation to generate biologically relevant isoindolines and β‐lactams. The product selectivity is influenced by the employed ligand, with NHCs favoring the product of remote C−C coupling against products arising from direct C−C coupling and N‐demethylation.