Controlled laboratory‐scale column deposition experiments were conducted using a well‐characterized mutant of the Escherichia coli (E. coli) K12 strain to obtain insight into the mechanisms that give rise to the observed deviation from classical colloid filtration theory (CFT). Both the suspended effluent bacteria concentration and the spatial distribution of retained bacteria were systematically measured over a wide range of solution conditions using columns packed with spherical glass beads. Calculations of Derjaguin–Landau–Verwey–Overbeek (DLVO) interaction energies based on measured cell zeta potentials indicated that the bacteria should experience considerable repulsive interaction forces when approaching the glass bead surface. In spite of these predictions, bacterial adhesion was observed even at the lowest solution ionic strength investigated (3 mM) and increased with solution salt concentration. Comparison of these results with measurements obtained using model colloidal particles (polystyrene latex microspheres) and a different microbe (Cryptosporidium parvum) suggested that another non‐DLVO‐type interaction may be contributing to the observed deposition behavior. Furthermore, predictions based on a discrete dual deposition mode (DDM) model disagreed with measured fractions of released cells. Taken together, the experimental and modeling results suggest that the deposition behavior of bacteria in saturated porous media is influenced by additional interaction mechanism(s) or factors not considered in classical DLVO theory, such as local charge heterogeneities of the cell membrane and surface biomolecule‐specific interactions.


Commentaries on the Treatise have not always been clear as to why Hume includes a discussion of the virtue of female chastity among the apparently different artificial virtues of justice, promises, and allegiance. Placing Hume's discussion of chastity within its specific historical location can illuminate its presence and role in Book 3 of the Treatise and demonstrate how chastity is a virtue of social utility. An examination of the "practice of the world" can show how female chastity was a necessary virtue for the emerging "middling" classes of the eighteenth century in their pursuit of economic stability and social status.


This paper presents a new technique to minimize the UV Erasable, Electrically Programmable, Read-Only Memory (EPROM) cell based on N-channel double polysilicon gate MOS. The new technique features a fully self-aligned floating gate structure which reduces the EPROM cell size/bit to almost that of presently most advanced mask ROMs. A new fabrication process and the experimental results for both programming and erasure are presented. The dependence of characteristics on various device parameters are discussed with emphasis on the difference from conventional devices.


The purpose of this study is to identify the course of Islamization in the Department of
Informatics Engineering Faculty of Science and Technology UIN SGD Bandung. This
research uses descriptive method with qualitative approach, Data validation with technique
triangulation and source triangulation. Data analysis with interactive technique with data
reduction process, data analysis and conclusion. The result of the research: the position of
Islamic subjects, constitutionally in the base group of Basic Competence Subject; Curriculum
development refers to the National Standards of Higher Education encompassing the
development of intellectual intelligence, noble character and skills, in accordance with the
Vision, Mission and Purpose of the Faculty of Science and Technology, to prepare the Albul
ulul generation; syllabus and RPS, including; Course Description; Competency standards;
Basic Competencies;) Indicators; Learning Experience; Subject matter; Time; Tools / Learning
Resources; and assessment. Learning Strategy covers the theoretical concepts of the field of
knowledge and skills, by setting the specifications and qualifications of learning objectives on
changes in the behavior profile of learners; Consider and select an effective learning approach
system; and establishing procedures, methods and learning techniques; and success criteria
Assessment includes educative, authentic, objective, accountable, transparent, integrated
principles.


The present invention relates to a trapping device bedbugs, bed bugs such capture apparatus comprising: (a) bed bugs attracted material element; And (b) the path, includes a trap element for trapping, comprising at least one path: (ⅰ) upward slope segments; (Ⅱ) downward slope segment having an outer portion; And (ⅲ) trap comprising: a trap region, and characterized by having an average surface roughness of the upward slope segment and the down-slope of the segment is the outer portion of at least about 2.5 micrometer.


At a climactic moment, the pope and the other Catholic bishops called the Christian liturgy "the summit toward which the Church's activity is directed; at the same time the fount from which all its power flows." This summit and source was the first object of the Second Vatican Council in 1962—always embracing bom the occasions of worship and the entire, integral life of the Church. And so it was indeed the characteristic of the entire generation of the Christian life of the present writer.


Abstract A number of scholarly and ethical problems involved in the study and publication of ancient artifacts are discussed in this essay. The scholarly peril of basing historical or cultural interpretations on artifacts of uncertain or unknown provenience is illustrated by examples from recent scholarship, and the limitations of an artifact's capacity to communicate independently of its cultural context are assessed. The relationship between the antiquities market and scholarship is discussed in historical context, and the evolution over the past generation of related ethical and scholarly standards is considered.


The use of genetically modified cells for transplantation therapies is a promising approach for inducing regeneration after injury of the CNS and PNS. Transplantation of Schwann cells (SCs) in rodent and primate models of spinal cord injury and/or demyelination has provided significant evidence of their repair potential in the affected part of the CNS (for reviews see Bunge 2008; Lavdas et al. 2008; Bachelin et al. 2010). Recently, SC therapy has received increasing attention because of three main reasons. First, SCs are an important source of developmental signals influencing neuronal survival and differentiation. Second, the migration and differentiation of SCs play an important role for myelination during regeneration which, much like during development, are dependent on the interplay between axons and SCs (Mirsky et al. 1996). Finally, SCs are easily Received April 22, 2010; accepted September 6, 2010. Address correspondence and reprint requests to Kostas Iatrou, Insect Molecular Genetics and Biotechnology Group, Institute of Biology, National Center of Scientific Research 'Demokritos', Aghia Paraskevi Attikis, 153 10 Athens, Greece. E-mail: email@example.com and Rebecca Matsas, Laboratory of Cellular and Molecular Neurobiology, Hellenic Pasteur Institute, Vas. Sofias 127, 11521 Athens, Greece. E-mail: email@example.com These authors contributed equally to this study. Abbreviations used: BGH, bovine growth hormone; BmNPV, Bombyx mori nucleopolyhedrosis virus; BSA, bovine serum albumin; CMV, cytomegalovirus; DM, defined medium; DMEM, Dulbecco's Modified Eagle Medium; eL1-Myc, extracellular part of the cell adhesion molecule L1 bearing a myc tag; FCS, foetal calf serum; GFP, green fluorescent protein; HEK293, human embryonic kidney 293; m.o.i., multiplicity of infection; NF-200, neurofilament; PBS, phosphate-buffered saline; SC, Schwann cell; TSA, trichostatin A. Abstract For biotechnological applications, insect cell lines are primarily known as hosts for the baculovirus expression system that is capable to direct synthesis of high levels of recombinant proteins through use of powerful viral promoters. Here, we demonstrate the implementation of two alternative approaches based on the baculovirus system for production of a mammalian recombinant glycoprotein, comprising the extracellular part of the cell adhesion molecule L1, with potential important therapeutic applications in nervous system repair. In the first approach, the extracellular part of L1 bearing a myc tag is produced in permanently transformed insect cell lines and purified by affinity chromatography. In the second approach, recombinant baculoviruses that express L1-Fc chimeric protein, derived from fusion of the extracellular part of L1 with the Fc part of human IgG1, under the control of a mammalian promoter are used to infect mammalian HEK293 and primary Schwann cells. Both the extracellular part of L1 bearing a myc tag accumulating in the supernatants of insect cultures as well as L1-Fc secreted by transduced HEK293 or Schwann cells are capable of increasing the motility of Schwann cells with similar efficiency in a gap bridging bioassay. In addition, baculovirus-transduced Schwann cells show enhanced motility when grafted on organotypic cultures of neonatal brain slices while they retain their ability to myelinate CNS axons. This proof-of-concept that the migratory properties of myelin-forming cells can be modulated by recombinant protein produced in insect culture as well as by means of baculovirus-mediated adhesion molecule expression in mammalian cells may have beneficial applications in the field of CNS therapies.


Abstract: The tetramethyldibenzocyclam derivative, was synthesized and characterized and was used for fabrication of potentiometric sensor for Ni 2+ metal ion. 5,7,8,14-tetramethyldibenzo[b,i]-1,4,8,11-tetrazacyclotetradecanenickel(II)chloride, ([Ni(Me 4 Bzo 2 [14]ane N 4 )]Cl 2 ) (II) was obtained in good yield as orange red salt by Fe/HCl reduction of the corresponding tetraazaannulene complex [Ni(Me4Bzo 2 taa)], (I). Membrane having [Ni(Me 4 Bzo 2 [14]aneN 4 )]Cl 2 (II) as electroactive material, sodium tetraphenylborate (NaTPB) as an anion discriminator, dibutyl butylphosphonate (DBBP) as plasticizer in PVC matrix in the percentage ratio 5.0:2.5:200:200 (II:NaTPB:DBBP:PVC)(w/w) exhibits a linear response to Ni 2+ in the concentration range 7.0×10 -6 - 1.0×10 -1 M with a slope of 29.8±0.2 mV/decade of activity and a fast response time of 12s. The sensor works well in the pH range 2.0-7.6 and can be satisfactorily used in presence of 40% (v/v) methanol, ethanol or acetone. The sensor is highly selective for Ni


Objective To investigate clinical effect of different ways in the treatment of femoral fractures. Methods 95 cases of femoral fracture patients were divided into control group(n=45) and observation group(n=50). The control group was given conventional dynamic hip screw fixation, while observation group was given percutaneous locking compression plate. Efficacy of two groups was compared.Results Total efficiency of 3 and 6 months of observation group was higher than control group(P0.05).Pain score, range of motion score and walking condition score of two groups had no significant difference(P0.05). Hip joint function of observation group was higher than control group(P0.05). Complication rate of observation group was significantly less than control group(P0.05). Conclusion Percutaneous locking compression plate has a low complication rate, a good treatment effect and should be widely applied.


Deep vein thrombosis can strike without warning, leading to serious morbidity or life-threatening complications. Your quick intervention can keep your patient from becoming another statistic.


The distribution of the taillight shiner, Nntmpis maculatus (Hay), within Arkansas is discussed based on personal collections, literature citations and a search of museum records. N. maculatus appears to be a typical Coastal Plain physiographic province inhabitant occurring below the Fall Line, and it nears its western and northern range limits west of the Mississippi River in Arkansas. Data are provided on preferred habitat, and suggestions are provided as to the current status of the taillight shiner within Arkansas.


Based on teaching theories and teaching practice,this paper discusses and analyses the problems in the design of questions,the expression of the questions,the control of the questions in order to better the quality of questioning in classroom and to improv the quality and efficiency of classroom.


Programs can be composed from features. We want to verify automatically that all legal combinations of features can be composed safely without errors. Prior work on this problem assumed that features add code monotonically. We generalize prior work to enable features to add and remove code, describe our analyses and implementation, and review case studies. We observe that more expressive features increase the complexity of developed programs rapidly -- up to the point where tools and automated concepts as presented in this paper are indispensable for verification.


This paper considers a subset of the computer-mediated communication (CMC) that took place during the flooding of the Red River Valley in the US and Canada in March and April 2009. Focusing on the use of Twitter, a microblogging service, we identified mechanisms of information production, distribution, and organization. The Red River event resulted in a rapid generation of Twitter communications by numerous sources using a variety of communications forms, including autobiographical and mainstream media reporting, among other types. We examine the social life of microblogged information, identifying generative, synthetic, derivative and innovative properties that sustain the broader system of interaction. The landscape of Twitter is such that the production of new information is supported through derivative activities of directing, relaying, synthesizing, and redistributing, and is additionally complemented by socio-technical innovation. These activities comprise self-organization of information.


The high-performance thin-layer chromatography (HPTLC) is widely used for quality control of herbal raw materials (HRM).
The purpose of this work were to define the problematic issues of quality control of herbal drugs in Ukraine and to develop a systematic scientific and methodological approach for the standardization of HRM and herbal drugs using the modern analytical technique of HPTLC: to optimize the existing and develop new methods of identification and determination of adulterations, and to develop alternative methods of quantitative determination, as well as studying of the stability.
As a result of a critical evaluation of existing approaches for the standardization of HRM and herbal drugs of Ukraine's flora, numerous problematic issues were identified, including the existence of a limited number of national monographs / national parts of monographs on the HRM of the Ukraine's flora, which were not previously standardized by other pharmacopeias; non-consideration of Ukraine's flora species (non-pharmacopoeial) in monographs on closely related species that introduced in the State Pharmacopoeia of Ukraine; lack of specificity of combinations of physical and chemical methods used for quality control; lack of specificity and reproducibility, the labor intensity of methods; necessity of usage of toxic solvents and precursors; use of different groups of markers and methods for the HRM and its finished product or HRM and its closely related species, etc. The proposed systematic scientific and methodological approach includes: a preliminary collection of information about the object of study, markers/groups of bioactive substances, approaches to its standardization; theoretical evaluation of existing techniques of quality control in monographs on HRM and experimental approbation using samples of domestic plants, determination of the need for optimization of existed methods by the parallel development of specific, reproducible and documented methods for identification, adulterations' detection, quantification, and bio-detection (if necessary) by HPTLC method. The approach is illustrated with examples.
The proposed approach can be used for comprehensive HPTLC analysis of domestic HRM and herbal drugs for research, prevention of adulteration, standardization of initial HRM and its finished product, pharmaceutical development, and stability studies.


Stephen Nash is a qualified accountant and holds the following degrees from the University of Queensland: B.Comm., B.Econ. (Hns.), B.A. In addition to these degrees he holds a Masters degree in Economics (Hns.) from the University of Sydney, while also being an associate of the Securities Institute of Australia. Recently, he completed the academic requirement for a Ph.D. at the University of Cambridge. He has published a book on economic theory in 1998 entitled: Cost Uncertainty and Welfare: Frank Knight's Theory of Imperfect Competition. In addition he is a fellow of the Cambridge Commonwealth Society. In terms of practical experience, he has a wide experience in financial markets in a variety of senior roles, mainly focusing on institutional investments.


Adenosine phosphosulfate (APS) reductase is one of key enzymes in the sulfur assimilation pathway in higher plants, catalyzing the formation of adenosine 5′-phosphosulfate from sulfate and ATP. In order to improve sulfur uptake capacity of water spinach (Ipomea aquatica), a plant which commonly grows wild in Southern Asia and has good potential for sequestration of environmental pollutants like sulfuric compounds, an Arabidopsis gene (APR1), encoding a plastid-resident APS reductase, was introduced into cut cotyledons via Agrobacterium-mediated transformation. Among 267 regenerated shoots initially obtained from 2,119 cotyledon explants, two were found to efficiently express the introduced gene and could be grown to maturity. APS reductase activity in leaves was estimated to be over 2-fold the wild-type level. Upon cultivation in the presence of 2 mM sodium sulfate, a 2.5-fold higher sulfate uptake was observed in comparison with wild-type plants. When grown in the presence of toxic levels of sulfide or cadmium, they showed a higher tolerance with increased fresh weight as compared with controls. These results suggest that transcription from the introduced gene indeed strengthened the sulfur assimilation pathway, and that the generated plants may be practically useful for phytoremediation.


3. Christ is the one Mediator of reconciliation. If all things were created by Christ and for him, then he alone can unite them, when evil threatens to disintegrate them whether they are things in earth or in heaven, things visible or invisible. If all the fullness of God dwells in Christ and he has made peace through the blood of his Cross, then what we have here is a cosmic peace. There are no differences under heaven, or even in heaven, which do not fall under the reconciling power of Christ and his Cross. Even the visible and the invisible realities are reconciled to one another. If this is the Christ whom we preach, the one Mediator of reconciliation through the blood of the Cross, how can we preach that Gospel, unless we are prepared to act out that reconciliation in our own lives and bodies, and so refuse to let divisions among


A method to evaluate aerodynamic performances of scramjet engines by using multi-probe rakes was proposed. The aerodynamic tests were carried out under Mach 4 flight conditions. The Pitot and static pressures were measured at 250 points in the cross sectional area of the engine exit by the rakes. Local mass flux and thrust function were evaluated from the pressure measurement at each point and integrations of these values enabled to obtain the mass flow rate and the stream thrust at the engine exit. The air capture ratios were independently measured by the rakes and a conventional choked flowmeter. The air capture ratios measured by these two methods agreed within 2%. It was found that the rakes enabled to measure the air capture ratio more simply than the flowmeter. Additionally, the effect of boundary layer ingestion to an internal drag was investigated by the rakes. The decrease of air capture ratio measured by the rakes showed that the ingested boundary layers were separated in the inlet. The pressure drag of inlet increased by the separation and the pressure thrust decreased by the decrease of air capture ratio. As a result, the internal drag increased when the forebody boundary layer was ingested.


Nd-doped MoN was prepared by thermal permeation of rare earth Nd in MoN using FeMo6 as the precursor. XRD, DTA, XPS and XRF have been used to characterize the FeMo6 precursor and the thermal treated samples. XRD, XPS and XRF results show that FeMo6 structure is decomposed and Nd-doped MoN is formed during the thremal treatment. XPS results also give the evidence that it is Nd3+ ion that can be permeated into the bulk of MoN. The conductivity of MoN is increased from 0.228 S·cm-1 to 2.649 × 102 S·cm-1 by Nd doping.


The Association of Language Testers in Europe has established a set of common standards for language exams which cover all stages of the language testing process. The international ECL language examination system works on meeting these so-called 'minimum standards`. In the course of this quality assurance process special attention is paid to the quantitative and qualitative analysis of the test results. After each exam, ECL experts carry out statistical analyses in order to compute the difficulty, discrimination and reliability of the task items. For this purpose, the experts deploy the measurement methods of the Classical Test Theory on the one hand, and the Rasch model, on the other hand. Unlike the psychometric tests of the Classical Test Theory, the Rasch measurement model indicates misfits, or in other words test items having a poorer quality compared to the rest of the items and , therefore, do not fit the model. The present paper deals with the issue of misfit items in German language tests measuring listening skills at level B2 according to CEFR. Those items which were indicated as misfits by the Rasch model in the course of ten exam terms are carefully examined; the reasons for their `malfunction` are then thoroughly searched for. The findings of these analyses are to be applied by item writers in the course of future test developments.


As is well known, Huckel's method, when applied to straightchain conjugate systems of N C atoms gives the formula: kTT tk = a — 2/J eos N 41 for the different energy leveis. For cyclic conjugated systems with N atoms in the ring, it gives: 2knty, — a -\2lS eos . N However, in standard textbooks it is quite unusual to find the deduction of these formulas. The author knows only two methods for the deductions. The first, given by T. K. Rebane (9), uses the solution of finite difference equations, whieh is a mathematical tool unfamiliar to most chemists. The second is given by R. Pauncz (7). Even though the latter uses better known mathematical techniques, it employs the variable chango X =z 2cos 6. This implies a drastic reduction in the variation interval of X which is done without any justification. This work attempts to show that the chango can be made without endangering the physical meaning of the results. I P A R T E REPASO DE ALGUNOS ASPECTOS DEL METODO DE HUCKEL En el metodo de Huekel para el estudio de las moleculas conjugadas (1), (2), (3) y (4), el paso fundamental consiste en el planteamiento y resolucion del determinante secular que permite obtener los valores permitidos de la energia para los estados estacionarios del sistema. Si se tiene un sistema conjugado, con N atomos de carbono, el determinante secular en este metodo tiene la forma: d u di2 di3 . . . diN d21 d l l d23 . . . d2N


INTRODUCTION Live influenza vaccine has been used extensivelyin the U.S.S.R. (Ritova, Zhukovsky & Yevstigneyeva, 1963; Smorodintsev, Alexandrova, Chalkina & Selivanov, 1965), in eastern Europe (Starke, Siebelist & Hiller, 1964) and occasionally in other countries (Okuno & Nakamura, 1966). In England five trials of this vaccine have been made since 1960; the first two during 1960-61 (McDonald, Zuckerman, Beare & Tyrrell, 1962) and the third in 1962 (Andrews et al. 1966). The findings from these three trials were encouraging in that serological evidence of symptomless infection was produced by the vaccine in most recipients and the volunteers were apparently resistant to re-infection with a challenging dose of live virus given intranasally 1 month later. Accordingly, in 1963 a field trial was made to try to assess the protection conferred against influenza. Approximately 1500 personnel of the Royal Air Force were vaccinated and a similar number who acted as controls received an inert fluid. The antibody response to the batch of vaccine used in this trial was much less satisfactory than in the previous investigations, and did not suggest that adequate protection had been induced. However, there was no outbreak of influenza during the follow up, and although a few cases of influenza were observed in both the


In physical simulation, it is frequently useful to define constraints between deformable objects, ensuring that one object follows another. Existing techniques for enforcing these constraints define the relationship between the objects using barycentric coordinates, a linear combination of vertices. While simple to implement and understand, barycentric coordinates have one important drawback: for stability, weights must be non-negative, which limits the types of constraints that can be defined. We introduce the Point Cloud Glue, which uses the nearest fit rigid rotation (the Procrustes transform) to the deformable object's particles. Our key contribution is to demonstrate that we can differentiate through this minimization in a numerically stable manner, allowing our method to be used in many constrained dynamics systems including those based on bindings/embeddings and those based on Lagrange multipliers. We demonstrate the flexibility of our method through several examples.


Richard E. Clark is one of the outstanding leaders in the field of Educational Technology. In this article,the author reviews his ideas on Educational Technology and his contributions to the theory-building and practice-improvement of the field from the three dimensions—criticism,exploration,and practice,and tries to understand the implications of his ideas for the future.


Background & Aims: Health and medical problems of prisoners are health challenges. In an environment where the most important priority is maintaining order, control, and discipline, maintaining health and providing healthcare will have its own challenges. For this reason, some countries have transferred the responsibility for providing health services in prison to the Ministry of Health. We aimed to investigate the developments and changes in providing health services to prisoners and their different structures in different countries. Materials & Methods: English language articles in Scopus, Google Scholar, and PubMed databases were searched. Advanced search options were used, initially based on the titles and keywords. Articles published until September 2019 were included using the following keywords: Prison, Jail, Primary care, Correlational health, Nursing, Prisoners, Health, and Healthcare. Results: Prison health was addressed not as an independent matter but as part of the duties of the Ministry of Health and the National Health System or the Ministry of Justice in each country. Reports from research carried out in France, Scotland, the Netherlands, Norway, Afghanistan, England-Wales, and New South Wales suggest a fundamental shift in the health care of prisoners in these countries and the process of transferring responsibility from the Ministry of Justice to the Department of Justice are among gained


During the 1990s an intense programme of high capacity road construction was carried out in the Spanish road network. This considerably improved accessibility to municipalities. The aim of this paper is to determine whether this greater accessibility has had positive effects on the creation of industrial establishments. We analyze the location decisions of firms at a municipality level and in 2-digit manufacturing industries (11 industries). The main contributions of this paper are the variables and econometric techniques we use. As well as the usual variables, such as specialization or the diversification of the labour force, we use more innovative variables such as local added value, road accessibility, and the characteristics of firms in neighbouring municipalities. Our econometric techniques are space models with discrete dependent variables. (♠)Department of Applied Economics I (Complutense University of Madrid) E-28223 Pozuelo de Alarcón Phone: + 34 913 942 470 Fax: + 34 913 942 499 (♣) Grup de Recerca d'Indústria i Territori Department of Economics (Rovira i Virgili University) Av. Universitat,1; 43204 – Reus Phone: + 34 977 759 800 Fax + 34 977 759 810 (♦) Department of Applied Economics II (Complutense University of Madrid) E-28223 Pozuelo de Alarcón Phone: + 34 913 942 476 Fax: + 34 913 942 457 *This research was supported by the Spanish Ministerio de Fomento (Ayuda a la investigación en el área de transporte: OM 1124/2002 and Proyecto de I+D en el Área de Transportes: FOM/486/2003 and FOM/3595/2003). The second author also received funds from the CICYT (SEJ2004-05860/ECON and SEJ2004-07824/ECON). Any errors are, of course, our own.


The success of any economically viable herbal cultivation programme lies in the appropriate selection of he r- bal plants. Many things will have to be considered in selecting herbs viz. adaptability in natural environment, economic demand in herbal industry and agroclimatic aspects. The present work embodies the results of the scrutiny of herbal composition of popular branded Ayurvedic medicines. In addition, with the help of field survey and available literature, plants were identified which are naturally growing in different habitats of the Bhabhar region of the Garhwal Himalaya, Uttarakhand. On the basis of utility in herbal medicines and their ability to grow n aturally, plants are further shortlisted for the cultivation. The prominent herbs recommended are: Aloe barbadensis, Bacopa monnieri, Boerhavia diffusa, Plumbago zeylanica, Tinospora cordifolia, Withania somnifera etc. The promotion of cultivation of these useful herbs would ensure sustainable biodiversity conservation and alleviation in the economic conditions of the rural people of the Bhabhar region of Garhwal Himalaya.


BepiColombo was launched on 20 October 2018 from the European spaceport Kourou in French Guyana and is now on route to Mercury to unveil Mercury’s secrets. BepiColombo a joint project between the European Space Agency (ESA) and the Japanese Aerospace Exploration Agency (JAXA) consists of two orbiters, the Mercury Planetary Orbiter (MPO) and the Mercury Magnetospheric Orbiter (Mio). It will perform measurements to increase our knowledge on the fundamental questions about Mercury’s evolution, composition, interior, magnetosphere, and exosphere.

During its 7-year long journey to the innermost terrestrial planet Mio and MPO are connected to each on-top of the Mercury Transfer Module (MTM). The MTM contains a solar electric propulsion engine and will bring the two spacecraft to Mercury. In late 2025, this ‘stack’ configuration is abandoned, the MTM will be jettisoned and the individual elements spacecraft are brought in to their final Mercury orbit: 480x1500km for MPO, and 590x11640km for Mio.

On its way BepiColombo with its state of the art and very comprehensive payload has several opportunities for scientific observations - during the cruise into the inner solar system and during its nine planetary flybys (one at Earth, two at Venus and six at Mercury). However, since the spacecraft is in a stacked configuration not all of the instruments can be operated during the cruise phase.

Some of the instruments have been already operated regularly or partially during the flybys in their “scientific” observation mode: e.g. the magnetometer (MPO-MAG), the accelerometer (ISA), the environmental sensor (BERM), the gamma-ray and neutron spectrometer (MGNS), the solar intensity x-ray and particle spectrometer (SIXS), the radio science experiment (MORE), using the X-band and the Ka-band, the thermal infrared spectrometer (MERTIS), the UV spectrometer (PHEBUS) and some sensors of the SERENA suite. Also, instruments or some parts of the instruments of the Japanese Mio spacecraft like the dust monitor (MDM), the plasma wave instrument (PWI), the particle and plasma experiments of MPPE and the magnetometer (MGF) were already successfully operated in their science modes. BepiColombo also took regular “selfie” images with their three monitoring cameras on the MTM. These cameras were also able to take a sequence of outreach images during the flybys at Earth and Venus in 2020. Other instruments such as cameras and NIR spectrometer (SIMBIO-SYS), the laser altimeter (BELA), the x-ray spectrometer (MIXS), and parts of the electron, neutron, and iron sensors of SERENA on MPO and MSASI and some dedicated sensors of PWI and MPPE are operational, but can only be used in their scientific modes after the Mercury in-orbit commissioning in early 2026 because their field of view is blocked by the underlying Transfer Module.

Despite the reduced instrument availability, scientific and engineering operations has been scheduled during the cruise phase, especially during the swing-bys. A status of the mission and instruments and a summary of first results from measurements taken during the first three years en route to Mercury will be given.


ABSTRACT Animal models of familial juvenile onset of Alzheimer's disease (AD) often fail to produce diverse pathological features of the disease by modification of single gene mutations that are responsible for the disease. They can hence be poor models for testing and development of novel drugs. Here, we analyze in vitro-produced stem cells and their derivatives from a large mammalian model of the disease created by overexpression of a single mutant human gene (APPsw). We produced hemizygous and homozygous radial glial-like cells following culture and differentiation of embryonic stem cells (ESCs) isolated from embryos obtained from mated hemizygous minipigs. These cells were confirmed to co-express varying neural markers, including NES, GFAP and BLBP, typical of type one radial glial cells (RGs) from the subgranular zone. These cells had altered expression of CCND1 and NOTCH1 and decreased expression of several ribosomal RNA genes. We found that these cells were able to differentiate into astrocytes upon directed differentiation. The astrocytes produced had decreased α- and β-secretase activity, increased γ-secretase activity and altered splicing of tau. This indicates novel aspects of early onset mechanisms related to cell renewal and function in familial AD astrocytes. These outcomes also highlight that radial glia could be a potentially useful population of cells for drug discovery, and that altered APP expression and altered tau phosphorylation can be detected in an in vitro model of the disease. Finally, it might be possible to use large mammal models to model familial AD by insertion of only a single mutation. Summary: Insight into astrocyte and radial glia pathology in an in vitro culture system derived from the APPsw pig.


Excavation of spillway's extra-large chamber lies in area crossing F8 fault,karst cave and its influenced area,so,how to prevent land slipping and what kind of support to adopt is a key and difficult point in construction,especially constructional support of upper excavation.This article introduces the upper excavation by composite constructional measures,such as advancing geological drilling in karst caves area,excavation of short benches in upper and lower structure,self-boring type anchor rod and small conduit grouting combined with steel grating,shotcrete support.


Construction companies always try to employ practical tools to assess risks and determine project contingency, yet the uncertain nature of risk makes it difficult to ensure that the assessment process is accurate or the agreed-upon project contingency is sufficient to deal with such uncertainty. This paper introduces a novel contingency determination procedure that employs fuzzy arithmetic in carrying out its computational steps. Fuzzy linguistic scales are used in this procedure to help experts assess the probability and impact of events using linguistic terms that are described by fuzzy numbers instead of inaccurate, single crisp values. The introduction of fuzzy logic helps experts use their own judgment-rather than relying on historical data-in determining contingency that deals with the shortcomings of applying the probabilistic risk analysis approaches in the absence of historical risk data. The paper also illustrates a new user-friendly software tool, namely, Fuzzy Contingency Determinator, which has been developed to carry out the steps of the procedure. The main contributions of this paper are (1) the introduction of a new contingency determination procedure, based on fuzzy logic, which can handle the subjective uncertainty of experts in assessing critical events leading to risk and opportunity and in determining contingency, and (2) the implementation of the procedure using a simple and user-friendly software tool.


INTRODUCTION: The objective of this study was to examine the effect of maternal antidepressant exposure on first- and second-trimester maternal serum markers for aneuploidy. METHODS: We conducted a 10-year retrospective cohort study within a large health care organization. Pregnant women diagnosed with depression who underwent serum screening for aneuploidy were identified. Antidepressant exposure was defined by a filled prescription. Levels of pregnancy-associated plasma protein-A, alpha-fetoprotein, estriol, inhibin, and second-trimester human chorionic gonadotropin (hCG) were obtained, expressed as multiples of the mean. We compared levels of serum analytes between women who were and were not exposed to antidepressants. Using recorded Patient Health Questionnaire scores, we assessed depression severity as a confounder. RESULTS: Antidepressant exposure occurred in 52% of 19,186 pregnancies. Mean inhibin levels were significantly higher in the unexposed group (1.124 multiples of the median compared with 1.084 multiples of the median, P=.003) as were mean hCG levels (1.188 multiples of the median compared with 1.165 multiples of the median, P=.007). Mean estriol levels were lower in the unexposed group (1.005 multiples of the median compared with 1.015 multiples of the median, P=.030). There were no statistically significant differences in the mean values of pregnancy-associated plasma protein-A or alpha-fetoprotein. In bivariate analyses, there were no interactions between analyte values and depression severity. There were no significant differences in the proportion of patients with one or more abnormal level of serum analytes between exposed and unexposed groups. CONCLUSION: Antidepressant exposure affects mean levels of inhibin, hCG, and estriol. As a result of our large number of participants, small differences could be detected. Further research is necessary to determine if such differences are of clinical significance.


Zoumaping area is a polymetallic mineralization district, where there are many tungsten, tin, lead, zinc and silver deposits. The deposit genesis is analyzed on the basis of the mineralization characteristics summarized up in the article. The ore prospecting direction is pointed out as well.


A method for printing on containers, particularly glass bottles or plastic bottles, comprising the steps of: pretreating a container by roughening the surface to be printed; Printing on the roughened surface of the container; and post-treating the container, in particular by means of drying or UV light treatment.


Large machine learning models based on Convolutional Neural Networks (CNNs) with rapidly increasing numbers of parameters are being deployed in a wide array of computer vision tasks. However, the insatiable demand for computing resources required to train these models is fast outpacing the advancement of classical computing hardware, and new frameworks including Optical Neural Networks (ONNs) and quantum computing are being explored as future alternatives. In this work, we report a novel quantum computing based deep learning model, the Quantum Optical Convolutional Neural Network (QOCNN), to alleviate the computational bottleneck in future computer vision applications. Using the MNIST dataset, we have benchmarked this new architecture against a traditional CNN model based on the seminal LeNet architecture. We have also compared the performance against previously reported ONNs, the GridNet and ComplexNet, and a Quantum Optical Neural Network (QONN) that we built by combining the ComplexNet with quantum-inspired sinusoidal nonlinearities. Our work extends the prior research on QONN by adding quantum convolution and pooling layers. We have evaluated the models using the metrics of accuracies, confusion matrices, Receiver Operating Characteristic curves, and Matthews Correlation Coefficients. The performance of the models were similar, and the metrics indicated that the new QOCNN model is robust. Finally, we estimated the gains in computational efficiencies from executing this novel framework on a quantum computer, concluding that switching to a quantum computing based approach to deep learning may result in comparable accuracies to classical models while simultaneously achieving unprecedented boosts in computational performances and power allocation.


This work investigates the original meaning developed by the ancient Greeks about law, as well as the cultural and rational conditions that contributed to its formation. The discursive aspect of the knowledge inaugurated by Greek philosophy is examined as an essential element of human emancipation against nature and the divine, and consequently, as a condition for the development of the democratic experience and the notion of law as an expression of the will of citizens. In addition, the etymological origin of the terms used to refer to laws is investigated, as well as the senses associated to them in the process of profound transformation that the very notion underwent. It is explained, as well, the duality between phýsis (the just according to nature) and nomos (the just according to human laws) exposed in the Greek literature and in the discourse of the sophists, attempting to comprehend the crisis in which the new notion of law and its uncertainties, embodied in this first democratic experience, had thrown the spirits of the time and even democracy itself. Finally, it is examined the important and original contributions of Plato and Aristotle in theirs efforts to overcome those uncertainties and to establish a notion of law founded on rational demands.


Introduction: The rapidly changing health care needs of clients, the changing roles of nurses, and rapid technological advancement make Continuous Nursing Education (CNE) necessary for nurses to maintain up-to-date nursing knowledge and skills to face the ever-increasing societal demands. Objective: The objective of this study is to identify factors that motivate and deter CNE participation among nurses. Methods: A cross-sectional descriptive study design was conducted in a selected private hospital, Penang, Malaysia. 100 respondents who fulfilled the inclusion criteria participated in this study. This study utilised a self-administered questionnaire related to factors that motivate and deter nurses' participation in CNE. Results: The results of this study showed that both factors that motivate and hinder CNE participation among the registered nurses were above the mean of 3.0 out of 5 scores. above theAll factors that influence have mean of more than 3.0. There is no significant difference between various categories of the department on factors that influence CNE participation among registered nurses at the selected private hospital in Penang; F (6, 81) = 0.558, p = 0.763 > 0.05. Conclusion: This study indicated that there is a need to develop an effective strategy for nurses to participate in the future CNE.


ABSTRACT:This article discusses three strategies that TV shows have increasingly employed in recent years to produce what Jason Mittell, in an essay that marked the beginning of his thoughts on the issue, has called "narrative complexity": unreliable narration, counterfictional scenarios, and ellipses and anachronological narration. It uses the last minutes of "The Wheel," the final episode of the first season of AMC's Mad Men (2007–15), as its primary example. More specifically, this article proposes three different interpretations of the final moments of that episode. These readings have in common that they underline one of Mittell's central claims, namely that serial television shifts comprehension processes toward conscious hypotheses in what he describes as "operational aesthetic." However, the article will also assume a broader perspective throughout and demonstrate that the three interpretations it develops are instances of more widely spread phenomena that merit far more attention than a single article can provide. Thus, the article offers, on the one hand, a close reading of an episode of Mad Men against the background of the early seasons of the show, but, on the other, it also identifies three topics for further fruitful research on television narrative more generally.


This paper examines the reception of Aristophanes' comedies Lysistrata and Assemblywomen in Augusto Boal's The Women of Athens. Written during the Argentine exile (1971- 1976), initially titled Lisa, the Liberating Woman, it is contemporary of the publication of the most prominent book by the Brazilian playwright, Theater of the Oppressed (1975, Brazilian edition, 1974, Argentine edition), constituting, in a way, a practical answer to the theoretical questions proposed there. The play documents the reception of the aristophanic comedy in Brazil.


Cardenolides are a group of steroidal metabolites found in Digitalis lanata with potent cardioactive effects on animals. In plants, cardenolides are involved in various stress responses. However, the molecular mechanism of cardenolide increase during stresses is mostly unknown. Here we show that cardenolides were increased upon methyl jasmonate (MJ), sorbitol, potassium (KCl) chloride, and salicylic acid analog (BTH: 2,1,3-benzothiadiazole) treatments. However, the expression of three known genes for cardenolide biosynthesis did not correlate well with these increases. Specifically, the expression of progesterone-5β-reductases (P5βR and P5βR2) did not correlate with cardenolide increase. The expression of 3β-hydroxysteroid dehydrogenase (3βHSD) correlated with cardenolide levels only during the BTH treatment. Mining the D. lanata transcriptome identified genes involved in cholesterol and phytosterol biosynthesis: SSR1 (sterol sidechain reductase), SMO1, and SMO3 (sterol methyl oxidase). Surprisingly, the expression of all three genes correlated well with the cardenolide increase after BTH treatment. Phylogenetic analysis showed that SSR1 is likely involved in both cholesterol and phytosterol biosynthesis. In addition, SMO1 is likely specific to phytosterol biosynthesis, and SMO3 is specific to cholesterol biosynthesis. These results suggest that both cholesterol and phytosterol are involved in cardenolide biosynthesis. In summary, this work shows that cardenolides are important for stress responses in D. lanata and revealed a novel relationship between phytosterol and cardenolide biosynthesis.


Background:  The reported rate of post‐sternotomy mediastinitis is between 0.8 and 2.3%, with up to 79% of cases caused by staphylococci. Mediastinitis is associated with significant morbidity and mortality. Obesity and diabetes are the only risk factors consistently identified. The aims of the present study were to determine the incidence and risk factors for staphylococci post‐sternotomy mediastinitis and to audit its management.


The international capital market integration and currency crises of the last decade have renewed the debate on optimal exchange rate regimes. Research is mixed regarding what their effect has been on the system of exchange rate regimes and the anchor currencies at the centre of the system. The debate is complicated by growing empirical evidence that the de jure regimes announced by governments often differ from the de facto regimes that are actually applied. In this paper we divide the period 1990-2002 according to the major crises and use the generalized method of moments to identify the individual de facto regimes and relevant anchor currencies for each sub-period. We find that although intermediate regimes as a percentage of the overall database remained stable over the three periods, the type of peg and anchor currencies varied considerably. Pegs on a single currency fell from 62% of the sample in the first period to 49% in the second period, then rose to 66% in the third period. Basket pegs rose from 33% in the first period to 51% in the second period and back to 34% in the third period. Independent floats disappeared after the first period. When we group countries according to their access to capital markets, we find that all nine of the developed countries in the sample followed some type of intermediate regime for all three periods. We also find a trend towards hard pegs in the group of countries that has managed to increase its integration in the international capital markets. Our results also suggest that the US dollar remains the main anchor currency in the international financial system, even after the major currency crises and the rise of the euro.


Purpose

This study aims to evaluate casino-hotel visitors' tourism experiences which consist of multiple dimensions, and test their joint effects on visitors' positive emotions and satisfaction. The findings are expected to reveal how multi-dimensional tourism experiences could shape visitors' positive emotions, and empirically support positive emotions as the mediator between tourism experiences and satisfaction in the context of casino hotels.

Design/methodology/approach

A quantitative survey was conducted for this study. In all, 500 valid questionnaires were collected at four major casino hotels in Macao. Respondents were Chinese tourists who visited casino hotels in June. A structural model was developed and tested to understand the relationships between multi-dimensional tourism experiences, positive emotions and satisfaction.

Findings

Positive emotions were identified as "light pleasure" and "intense fun" emotions based on the context-specific measurement of casino hotels. The "light pleasure" emotions were found to be more effective in influencing respondents' satisfaction than "intense fun" emotions. Different dimensions of tourism experiences were found to have different levels of impact on respondents' positive emotions. The findings revealed how multi-dimensional tourism experiences influenced respondents' positive emotions which in turn determined their satisfaction.

Originality/value

The findings advanced the understanding of the relationships between tourism experiences, positive emotions and satisfaction in the context of casino hotels. The two types of positive emotions identified in the study add values to the literature of casino-hotel visitors and emotional experiences. This study suggests a further investigation into the scope and measurement of each dimension of tourism experiences in different tourism settings in future research. The findings provided some practical suggestions for the management of positive emotions and tourism experiences in casino hotels.


Critical reflection shows a great potential in enhancing professional practice and can be considered as a vital  component of teacher training courses.  In the context of teaching placements, critical reflection can act as an important lens through which students can interrogate, share and compare their experiences. In agreement with Stephen Brookfield's works (1995; 2005) which valued reflective practice as a mean of learning, this study applies critical reflection process to identify and analyse the ways student teachers have dealt with the incidents during their placement. This data, combining with assessment of students after placement collected by Department of Training and research of other lectures at  Ho Chi Minh City  University of Education, can produce an informative resource about placement for teacher training program.  The findings of this study might contribute to a better understanding of students' placement experiences and then inform future curriculum improvement in teacher education courses of Ho Chi Minh City University of Education.


Industrial Internet is widely used in the production field. As the openness of networks increases, industrial networks facing increasing security risks. Information and communication technologies are now available for most industrial manufacturing. This industry-oriented evolution has driven the emergence of cloud systems, the Internet of Things (IoT), Big Data, and Industry 4.0. However, new technologies are always accompanied by security vulnerabilities, which often expose unpredictable risks. Industrial safety has become one of the most essential and challenging requirements. In this article, we highlight the serious challenges facing Industry 4.0, introduce industrial security issues and present the current awareness of security within the industry. In this paper, we propose solutions for the anomaly detection and defense of the industrial Internet based on the demand characteristics of network security, the main types of intrusions and their vulnerability characteristics. The main work is as follows: This paper first analyzes the basic network security issues, including the network security needs, the security threats and the solutions. Secondly, the security requirements of the industrial Internet are analyzed with the characteristics of industrial sites. Then, the threats and attacks on the network are analyzed, i.e., system-related threats and process-related threats; finally, the current research status is introduced from the perspective of network protection, and the research angle of this paper, i.e., network anomaly detection and network defense, is proposed in conjunction with relevant standards. This paper proposes a software-defined network (SDN)-based industrial Internet security gateway for the security protection of the industrial Internet. Since there are some known types of attacks in the industrial network, in order to fully exploit the effective information, we combine the ExtratreesClassifier to enhance the detection rate of anomaly detection. In order to verify the effectiveness of the algorithm, this paper simulates an industrial network attack, using the acquired training data for testing. The test data are industrial network traffic datasets, and the experimental results show that the algorithm is suitable for anomaly detection in industrial networks.


Precise magnetic fields are necessary to achieve high-quality particle beam-transport in the SLAC beam switchyard. A discussion of the methods of magnetic measurements associated with testing and establishing these fields is presented. These measurements and some of the important results obtained are described. In order to satisfy the criteria placed on the transport systems each magnet was measured and the critical magnets of the transport system were selected for placement in the beam switchyard on the basis of several of their measured characteristics. A description of the selection procedure is presented, and the effects of the individual magnet differences are discussed. Details of measurement techniques and the resulting procedures which are used for setting up the beam switchyard for a particular momentum are given.


The genera of Australian buliniform planorbids have been examined anatomically and their classifi~ation reviewed. The major conclusions reached are.: 1. Isidorella is not congeneric with Bulinus and is an endemic Australian genus; 2. Iredale's genera Lenameria, Tasmadora and Mutalena are synonyms of Physastra Tapparone-Canefri which, in turn, is a synonym of Glyptophysa Crosse. Glyptamoda Iredale is also a synonym of Glyptophysa; 3. Oppletora Iredale, synonymised with Bulinus by Hubendick, is actually related to Glyptophysa and is placed in a separate subgenus; 4. Ancylastrum Bourguignat has been examined and the results confirm Hubendick's opinion that this limpet-like genus is related to Glyptophysa. Two species can be separated by simple anatomical characters; 5. The genus Bayardella Burch includes two species, B. johni and B. cosmeta, the latter once considered to be a species of Glyptophysa; 6. Amerianna Strand includes species with either a terminal or lateral pore on a simple pendant penis; 7. A new genus Leichhardtia is erected for the northern species Bullinus sisurnius Hedley 1918. All these genera are placed in the planorbid subfamily Bulininae. WALKER, J.c. Classification of Australian buliniform planorbids (Mollusca: Pulmonata). Records of the Australian Museum 40(2): 61-89. 61 The African planorbid Bulinus Muller, 1781 has become one of the best known and most intensely studied of all molluscs because of its role in the transmission of the human trematode parasite Schistosoma haematobium (Bilharz, 1852). Several Australian freshwater molluscs are morphologically similar to Bulinus and, as a consequence, this generic name has frequently been applied to lymnaceans from this country. This has not only caused confusion for taxonomists but has also supported the belief that snails capable of transmitting human schistosomes are present in Australia (Anon, 1972). The name Bulinus was first used by Adanson in 1757 in a description of a small freshwater mollusc from Senegal. Since the original description was preLinnean, Adanson cannot be quoted as author and Miiller, who used the name in 1781, is now given authorship. In 1815, in a compilation of Muller's work, Oken emended the spelling to Bullinus and this form was subsequently widely adopted by authors until Pilsbry & Bequaert (1927) pointed out that Bullinus Oken is an unnecessary emendation for Bulinus Muller, and has no status in nomenclature. The classification of Australian buliniform planorbids has been confounded since its beginnings by a surfeit of species names and an ignorance of generic relationships. These problems have their origins in the traditional reliance of taxonomists on the molluscan shell as a major taxonomic character, an unfortunate choice in the light of the extreme variability of the freshwater Basommatophora. From 1826, with the description of Physa novaehollandiae by Blainville, until 1881 (Tate & Brazier, 1881), 54 species of Physa Draparnaud were named from Australia. Tate (1882) was convinced, however, that the sinistrally coiled Australian freshwater snails were not physids and stated" ... in no instance have I found those distinctions which characterise Physa as separable from Bulinus. The mantle margin is neither expanded nor digitate". Cooke (1889) also considered that the "So Called Physae of Australia" were related to Bulinus. He also


Introduction: Diazoxide is the first-line treatment used to manage infants and children with hypoglycemia secondary to hyperinsulinemic hypoglycemia (HH), after initial stabilization of blood glucose. Recent changes in Pediatric Endocrine Society guidelines regarding definition of, and screening for hypoglycemia in the neonate led to an increase in the number of infants treated with diazoxide. Previous studies have noted various side effects of diazoxide. With the increased use of this drug in neonates, our aim is to further evaluate these side effects. Methods: We performed a retrospective case control analysis of all neonates admitted to a tertiary care center in New Jersey who were treated with diazoxide for hypoglycemia after a confirmed diagnosis of HH between 1/1/2015 and 9/1/2019. All subjects were younger than 6 months of age at treatment initiation with diazoxide. We collected data regarding general patient characteristics, diuretic dosing, findings on echocardiogram, blood counts, episodes of emesis, and quantity of feeds at time points before and after diazoxide initiation. Results: A total of 25 infants (64% males) met inclusion criteria and were included in the analysis. Based on echocardiogram results, one baby (4%) had pulmonary hypertension (PHTN) prior to initiation of diazoxide, and 20% after, with 5 cases (20%) of reopening of the ductus arteriosus (DA). Nine patients (36%) required a diuretic dose increase after diazoxide initiation. There was increased feeding intolerance with increased number of emesis events after diazoxide initiation (p=0.006). A week after initiation of diazoxide, there was no improvement in the percent of total oral intake as would typically be expected. Conclusion: New onset PHTN and re-opening of the DA were associated


Summary: A new oral antimycotic, the imidazole drug ketoconazole, was tested in 67 cases of fungal infections of the skin or the nails. One tablet of 200 mg ketoconazole was given daily. Eighty‐five per cent of the patients with dermatomycoses were clinically cured by the end of the six‐week treatment. Among them were four patients with a persistent mycosis on the volar side of the hand. Most patients with onychomycoses were still being treated at the time of this evaluation. In all of them healthy nails had been normally growing again. No adverse effects were noted.


A feedback control system can be structured for linear nonstationary process and measurement systems comprising a deterministic filter whose output is the independent variable of a linear control law. Subject to uniform controllability and observability, the filter and control gains can be specified to provide arbitrary and separable stability properties. If the filter gain is selected to produce a stabilizing effect on the state estimate, and the control gain is selected to produce a stabilizing effect on the process, the filter and control gains are shown to satisfy matrix Riccati differential equations. This suggests the use of stochastic optimal control theory when there is no quantitative measure of optimality, but it is desirable to assure the qualitative property that feedback be stabilizing. A concise derivation of the Kalman-Bucy filter is included in an appendix to illustrate the facility of approaching optimal estimation problems with the methods of stability theory.


Mucosa-associated lymphoid tissue (MALT) lymphoma is an extranodal low-grade B-cell lymphoma. Pulmonary MALT lymphoma is considered to originate from bronchial MALT and is also referred to as bronchial-associated lymphoid tissue lymphoma. Pulmonary MALT lymphoma is a rare disease, but it is the most frequent subset of primary pulmonary lymphoma. The median age at diagnosis of pulmonary MALT lymphoma is 50–60 years, with only few patients aged <30 years. This is the case report of a 19-year-old patient with pulmonary MALT lymphoma presenting with a multiple pulmonary consolidation pattern on computed tomography scans, who underwent successful chemotherapeutic treatment with a chlorambucil-based regimen.


Abstract : FY2010 presented unique challenges to the Department of Defense and specifically in the Department of the Navy, with the call to ensure that a 1% to 3% real growth is realized through a tail to tooth reappropriation of future funds for the continuation of innovations and combat operations. The naval aviation training program, under the management of the Chief of Naval Air Training (CNATRA), is on the tail end of this analogy, indirectly supporting combat operations through the training of student naval aviators (SNAs) from the Navy, Marine Corps, and Coast Guard services with training offered for limited number of students from the Air Force and foreign nations. The purpose of this project is to model the naval aviation helicopter pilot training program as a supply chain with the output of one stage of production providing the input of the next. Batch arrivals of selected naval aviators, pooling between stages, attritions, and squadron utilization rates combine to make this problem a complex model to quantify. The proposed model accounts for above mentioned factors and is validated through historical data and allows hypothetical student pooling scenarios to be tested and analyzed.


Objective Reliable results in MR flow measurements have been reported in humans. The current study was performed to evaluate the effects of a meal intake on the flow velocities in the superior mesenteric artery (SMA) and aorta by using 2D phase-mapping MRI. Materials and Methods A constant flow phantom generating 0–150 cm/s of flow velocities was constructed to evaluate the accuracy of MR flow measurements. Eleven healthy volunteers underwent serial MRI once before and three times after a mixed meal intake (700 kcal). Results Reliable MR flow measurements were validated in the constant flow phantom. In the healthy volunteers, the SMA and aorta had triphasic flow velocity waveforms in one cardiac cycle. Ingestion of a mixed meal increased flow velocities in the SMA. Peak velocities were observed at 20 min after the meal. The aortic flow velocities were unaffected by the meal. Conclusion A 2D phase-mapping MR technique is feasible to evaluate the SMA and aortic flow velocities. Evaluation of the flow velocities in the SMA may contribute to understanding intestinal as well as hepatic conditions in humans.


We show the first results of a new cavity based haloscope searching for dark photons with masses around $34~\mu\text{eV}$. Dark photons are hypothetical vector particles and a compelling dark matter candidate. Having the same quantum numbers as photons a kinematic mixing between both is expected, leading to conversions from dark photons to standard model photons, where the photon frequency depends on the dark photon mass. For wavelengths in the microwave regime resonators are typically used to enhance the signal. A new experiment is setup at the University of Mainz. In this paper we present the initial results from the new setup searching for dark photons utilising a 8.3 GHz copper cavity at LHe temperatures. Limits on the kinetic mixing parameter $\chi<(6.20 \pm 3.15^\text{(exp.)} \pm 9.65^\text{(SG)}) \cdot 10^{-14}$ at 95\% CL are set at a single frequency as proof of concept. Finally the next steps of the experiment and expected sensitivity are detailed.


Citing two illustrative cases of acromegalic exophthalmos, M. LABBiE and L. JUSTIN-BESAN;ON (Bull. et Mem. Soc. Med. des Hop. de Paris, July 15th, 1935, p. 1221) emphasize the early appearance of this symptom in certain cases, the difficulty of differentiating acromegaly from Graves's disease, and, in advanced cases, the possibility of the exophthalmos being masked by the osseous hypertrophy. This sign may occur as early as three years before the acromegalic manifestations. Signs differentiating acromegaly from Graves's disease are the absence of goitre and tachycardia and a raised basal metabolism in the former. Animal experiments show that the exophthalmos caused by pituitary injections is inconstant and disappears under anaesthesia, and that the thyreotropic hormone is abundant in the urine in acromegaly but absent in Graves's disease. The pathogenesis of this exophthalmos is unknown; a direct effect on the orbital muscles or a stimulation of the thyroid or suprarenals is not a satisfactory explanation.


Abstract BACKGROUNDS Current standard of care for glioblastoma, consists of postoperative temozolomide (TMZ) concomitant with radiotherapy, followed by adjuvant TMZ monotherapy. Recently, an international phase 3 trial (EF-14) demonstrated that addition of tumor-treating fields (TTF) to adjuvant TMZ after completion of chemoradiotherapy extended median progression-free survival and overall survival by 2.7 months and 4.8 months, respectively, compared with TMZ alone in patients with newly diagnosed glioblastoma. TTF is now considered as a part of its initial treatment in the guideline in Japan (recommendation grade B). However,distinct from anticancer drugs,little is known or experienced using TTF as a therapeutic device so far, especially in management and handling. METHODS First six patients with newly diagnosed glioblastoma who underwent TTF were analyzed with special interest in medical and social supports to execute TTF at home. RESULTS TTF was first introduced in our institution in May 2016, but no patients were treated because of no coverage by medical insurance until December 2017. We further needed to wait to initiate TTF treatment until January 2019 when the contract to use TTF systems was finally made between the company and institution. Since then six patients were registered in five months. For its introduction to clinical practice,it is essential to establish new in-house environment with medical professions division in the facility including documentations of calculating instruction fees and usage guidance for home care application of TTF. It is also important to initiate providing information of TTF such as timing of visit by specific practitioners and potential medical and psychologic burdens to patients and their families during and after chemoradiotherapy to better understand this new modality leading to the consent acquisition. CONCLUSIONS Introducing TTF into clinical practice should accompany improvement of management in not only medical equipment and documentations but also patient care in hospital and home.


Based on t he Hongdao Channel Bridge of Qingdao Bay Bridge , the configurationd. The contact stress betweeny mechanics method. The mechanical property of cable-e under the composite effect of the worst load was discussed by the finitealyzed withl result reveals that the maximal Vonn the anchor hole of ear plate under the composite effect ofad. The ultimate bearing capacity of cable-pylon wit h steel box girder is 5. 02 times ofugh safety reservation.


* Abbreviation:
 HRSA — : Health Resources and Services Administration

Poor access to child and adolescent psychiatrists has long been a concern raised by pediatricians, families, and other stakeholders. Wait times for new appointments can be many months, and families may be required to travel long distances. In the article "The Growth and Distribution of Child Psychiatrists in the United States: 2007–2016" in this issue of Pediatrics , McBain et al1 evaluate whether we have made any progress in expanding the child psychiatry workforce, both in number and distribution. They found that from 2007 to 2016, the number of child psychiatrists increased by 21%, and the number of children in the United States declined slightly. The United States now has 9.75 child psychiatrists per 100 000 children aged 0 to 19. However, they found an eightfold variation in prevalence per 100 000 children among states, ranging from a low of 3.3 in Idaho to a high of 26.5 in Massachusetts. Child psychiatrists are still concentrated in metropolitan areas; 70% of counties do not have one.

There are challenges in evaluating how much the increase addresses the shortage. As the authors …

Address correspondence to David Axelson, MD, Department of Psychiatry and Behavioral Health, Nationwide Children's Hospital, 700 Children's Dr, Columbus, OH 43205. E-mail: david.axelson{at}nationwidechildrens.org


The finite height of the detector slit of a powder diffractometer has three observable effects: (1) the peak is shifted by an amount that is proportional to −cot 2θ; (2) the peak is broadened by an amount proportional to cot22θ; (3) an asymmetry is introduced into the peak shape that depends on cot32θ. If the underlying instrumental resolution function has a Gaussian shape, the slit height effects can be approximated, over a rather broad range of shapes for the vertical resolution function, by an Edgeworth series making use of one adjustable parameter. This peak shape function is compared with experimental observations and with other shape functions that have been proposed. A well characterized peak shape is at least as important as resolution when the data are to be used for structure refinement by the Rietveld technique, and diffractometers should be designed so as to keep the slit height within the range that leads to shapes that can be described mathematically. Diffractometers with multiple detectors can usefully have different vertical divergences for detectors that cover different angular ranges.


The history of surgery for tuberculosis from 1885 to 1950 reflects the history of thoracic surgery during that period. A steady stream of patients with apparently hopelessly advanced disease presented an enormous challenge to surgeons of that period. Much of what we have learned concerning the special problems of thoracic anatomy, technique, and anesthesia, as well as preoperative and postoperative care, came from this group of patients. However, the most enduring contribution of this period was a better understanding of respiratory physiology. Indeed, many pioneers in clinical lung physiology, both here and abroad, initially were stimulated by the problems of tuberculosis surgery, and some of our own observations will be emphasized here. The early surgeons were members of a small club who often cited each other by name in their publications, but did not bother to include references. Sometimes they devoted more than 100 pages to a minor change in technique; other times, they described major contributions in a single paragraph. Originally, of course, they were all general surgeons. Thoracic surgery was established with the founding of the American Association for Thoracic Surgery in 1918, and a colorful and individualistic approach was preserved in that group. During my first presentation to that Society in 1950, the Chairman, Dr. Edward O'Brien, restrained the speaker's time with a silver six-shooter; Dr. Max Chamberlain, presenting his experiences with segmental resection for tuberculosis (1), extended his time with a shotgun previously hidden behind a curtain, which he aimed at Dr. O'Brien. The introduction of antimicrobial drug therapy greatly increased the safety of tuberculosis surgery, but at the same time, the need for such surgery decreased rapidly. Today, a call in the operating room for a Tuffier retractor, a Lilienthal guillotine, or a Doyen raspatory meets with puzzled frowns from the nurses and an indulgent smile from the resident, who invariably suggests a sternal splitting approach as a better alternative —the passing of an era. The brevity of this review does not permit mention of all the great contributors to the field. Rather, an attempt is made to give the reader a feeling for an era, and for the almost insurmountable difficulties of major thoracic surgery initially performed without general anesthesia, without an understanding of respiratory physiology, and, for a long time, without blood transfusions. Some space is devoted to artificial pneumothorax, because its development was so intimately related to other forms of collapse therapy, because much subsequent surgery was designed to deal with the failures and complications of pneumothorax, and because our understanding of many physiologic principles is derived from experiences with artificial pneumothorax. Surgeons were preoccupied with treatment of cavities and, therefore, with mechanical detail. For a long time, they were less impressed with the contribution of Robert Koch than with another discovery made 3 yr later, that of Konrad Roentgen. Indeed, before radiography, a rational approach to surgery for tuberculosis was impossible. Perhaps one should not attempt to single out the greatest contributors in a field where so many made progress in small steps. In this country, many would think first of John Alexander, the founder of American tuberculosis surgery, whereas Alexander himself selected Sauerbruch as his most illustrious predecessor (2). My own reading over the years brings to mind a physician rather than a surgeon as the one who might have contributed more to the progress of tuberculosis surgery than any other person. Ludolph Brauer of Marburg and later of Hamburg had such a keen understanding of both anatomy and physiology that he was able to suggest to surgeons step by step many of the major improvements in collapse therapy during the first 20 yr of this century. He was the first to appreciate the physiologic consequences of paradoxical chest wall motion and therefore prescribed subperiosteal rather than total rib resection. Later, he developed positive-pressure breathing both for anesthesia and to counteract paradoxical motion. He was probably the first to appreciate the importance of preoperative evaluation of respiratory function. Among his many other contributions, he first defined pneumonosis, a condition that was described 20 yr later as "alveolar-capillary block." The earliest rational concepts for promoting healing of tuberculosis were based on autopsy findings that there was necrosis with cavitation, and that this was largely confined to the cephalad third of the lungs. It was believed that three mechanical factors prevented healing of these cavities: (7) the constant traction exerted on the cavity's walls by the static elastic recoil of the surrounding lung; (2) the dynamically augmented traction from the act of breathing; (3) the diminished apical blood and lymph perfusion due to the human upright posture. The first two of these factors were discussed more than 150 yr ago (3). Scientific evidence for the latter came only with Cournand's first recording of human right heart pressure in 1944 and the brilliant deductions therefrom by Dock (4). It comes as no surprise, therefore, that for the 100 yr before effective chemotherapy, phthisiologists and surgeons alike were preoccupied with mechanical means for preventing cavities and for promoting their closure.


The most common central nervous system (CNS) tumor in adult patients is meningioma, accounting for 30% of all intracranial tumors. Despite this, extracranial meningioma metastases are exceedingly rare, accounting for 0.1% of cases, with common locations for metastases localized to the lungs, liver, lymph nodes, and bone.

 We present a 55-year-old female with a past medical history of tobacco use, hypertension and depression, who initially presented due to a generalized tonic-clonic seizure. MRI brain revealed an intracranial lesion in the left occipital lobe with mass effect, requiring craniotomy and resection. Pathology was consistent with WHO grade I meningioma and post-operatively a small area of residual tumor remained. PET/CT found a left lung nodule, which was thought to be due to her smoking history and was followed with annual scans. Four years later, she had an increase in the size of the meningioma on surveillance MRI scans. The patient then required repeat craniotomy which redemonstrated pathology of WHO grade I meningioma, then treated with stereotactic radiation 14 Gy. The subsequent annual surveillance pulmonary scan showed a growth of left pulmonary nodule. She underwent a left lingual wedge resection and was found to have low grade spindle cell tumor, consistent with metastatic meningioma.

 Although rare, metastatic meningioma should be included in the differential diagnosis of patients with concomitant extracranial lesions. Our case highlights the importance of annual, surveillance scans of extracranial lesions in meningioma patients.


Armillaria luteo-virens is a kind of important biological resource in Qing-Tibet Plateau.The results of the analyzing on the nutritional compositions of Armillaria luteo-virens in the places of Qiling,Qinghai Lake,Geermu,Yushu,etc.,Qinghai province,show that it has higher nutritional value and diet-remedy and health-protection effects;its fat content is 0.97~1.52g/100g,its protein content 0.819~0.975g/100g,its reduced sugar 0.0126~0.0209g/100g,and there are also various inorganic elements beneficial for human body in it.Meanwhile,the present situations of its resource development are studied and the corresponding sustainable utilization measures are also proposed.


3 INTRODUCTION 3 LITERATURE REVIEW 4 ON-STREET PARKING 4 TRAFFIC CALMING USING ON-STREET PARKING 4 EMERGENCY VEHICLE ACCESS 5 SITE REVIEW 5 SOLUTION ALTERNATIVES 8 ALTERNATIVE #1 8 ALTERNATIVE #2 9 CONCLUSIONS 11 REFERENCES 12 ACKNOWLEDGEMENTS The Authors thank the city of Salem for the impetus for this project and guidance on its completion. DISCLAIMER "This report is the result of an academic exercise. The results and recommendations are the opinions of the student authors only." Street and lane widths considering parking and emergency vehicle access PSU CE 505 Spring 2010 Portland State University 3 ABSTRACT Several neighborhoods in Salem, OR have streets with parking permitted on both sides of the road, resulting in a narrow travel lane that may reduce response times for emergency response vehicles. However, two-sided parking configurations serve as a natural traffic calming device, keeping vehicle speeds in these residential neighborhoods at appropriate levels. This research proposes several alternatives that balance the issues of parking quantity, traffic calming, and emergency vehicle access. Two alternatives to the existing conditions that benefit emergency vehicle access are presented. Using chicanes to separate alternating sections of parallel parking on one side of the street is shown to provide adequate parking spaces, calm traffic speeds and meet emergency vehicle access needs. INTRODUCTION As arterial and collector roadways become congested, motorists often seek alternative routes that may pass through neighborhoods on roadways not designed to handle such volumes or speeds, posing safety risks for both residents and drivers. When through-vehicles become problematic to residents of the affected neighborhood, "traffic calming" devices may be employed to manage speed and volume and return a neighborhood street to its designed purpose as a local access route. Traffic calming involves the use of measures such as signing, pavement markings, and horizontal and vertical roadway deflections. Traffic calming affords the benefits of speed enforcement without the need for enforcement personnel and has been shown to reduce speed and AADT on treated roadways. One method of traffic calming, lane narrowing, involves purposely narrowing a street to make slower driving speeds seem more natural without imposing an overly artificial treatment, such as speed bumps. Lane narrowing may be accomplished at minimal cost by permitting parking on both sides of the street, a tactic common in several Salem neighborhoods. Recognizing a conflict of interest, emergency response agencies have raised issue with traffic engineers over the deliberate narrowing of lanes, which may directly slow emergency response times. This project aims to evaluate emergency vehicle access as a function of lane width and onStreet and lane widths considering parking and emergency vehicle access PSU CE 505 Spring 2010 Portland State University 4 street parking. A number of Salem's neighborhood streets are narrow (<26 feet) and include onstreet parking. These narrow streets exhibit traffic calming qualities, but may impede the response times of emergency vehicles. This project seeks to find a balance point between emergency response time and everyday safety – particularly the ability of emergency vehicles to access certain points – and livability in neighborhoods. This paper recognizes three main components within the issue of emergency vehicle access on streets with traffic calming treatments: (1) the need for adequate on-street parking in the problem areas, (2) the need for appropriate traffic calming measures to ensure vehicle speeds are kept within the desirable range, and (3) the need for safe and efficient access for fire trucks and other emergency vehicles. A wide body of research exists in each of these areas. A literature review conducted by the authors found a wide body of research applicable to each of the three components.


Starting from the theory that the substance of economic growth is the gross increase of social value produced by labors,and looking into the value differences produced by labor transfer as the benefit from social division of work and the transfering variables,the writers analyze the quantitative relationship between transportation development and economic growth,and establish a model about Markov relation between transportation development and social division of work.The result shows that the economic growth produced by transportation development is equal to the sum of value differences produced by labor transfer among industries.All of these provide the new ideas for mathematical analysis on the relationship between transportation development and economic growth.


One-dimensional Co3O4 nanotubes were grown in alignment on the surface of micron-sized Co3O4 hexagonal-box via a mild template-free wet chemical method. The nanotubes are ∼250 nm in diameter with several micrometers in length. The growth mechanism and phase formation for the vertically grown nanotubes on the surface of the boxes have also been investigated. The intermediates of α-Co(OH)2 and β-Co(OH)2 towards the final products of Co3O4 are also characterized. The magnetization, M(T), measurements for the micro-boxes with nanotubes reveals that the Neel temperature is suppressed from the bulk value of 40 K down to 22 K, possibly due to finite size effect. The Curie–Weiss analysis on the paramagnetic behavior above the Neel temperature gives the average effective moment of 4.4 μB per formula unit, slightly higher than 4.14 μB of its bulk counterparts. The electrocatalytic experiments for the oxidation of methanol reveal that the final product exhibits better catalytic performance compared with the intermediate product due to its higher specific surface area.


The accessibility of both bus stops and the pedestrian environment around bus stops is an important component in meeting the needs of passengers. Easter Seals Project ACTION is addressing the challenge of eliminating barriers around bus stops by developing a toolkit for assessing bus stop accessibility and safety. This article highlights the toolkit's key features and describes how they were developed and tested. The toolkit is designed for staff at transit agencies and public works departments who are responsible for bus stop design and placement. The toolkit includes a list of common bus stop accessibility myths; principles of barrier-free design; a sample bus stop checklist for transit and public works agencies; a sample bus stop checklist for transportation advocates and the general public; guidelines for creating safe and accessible bus stops; recommendations for organizational relationships; technology options; and considerations for rural stops.


Present a DOS multitask long distance communication system,which transmits data and sends commands from point to point between microcomputers. The program is a TSR. When the program is transmiting data,the user can simultaneously run its own programs or DOS commands. In other words,there is multitask on DOS. The function of the system can be called by users in commands or by programmers in assembler,C,or Foxbase source codes. There are reasonable cmmunication tasks dispatching algorithm and our own back screen communication protocol in the system, and it is a useful tool for programmers to develop communication software.


We demonstrate the effect of band structure on the superconducting properties of Pb by calculating the strong-coupling features in the optical conductivity $\ensuremath{\sigma}(\ensuremath{\omega})$ due to the electron-phonon interaction. The importance of momentum dependence in the calculation of the properties of superconductors has previously been raised for $\mathrm{Mg}{\mathrm{B}}_{2}$ [H. J. Choi et al., Phys. Rev. B 66, 020513(R) (2002); Nature (London) 418, 758 (2002)]. Pb resembles $\mathrm{Mg}{\mathrm{B}}_{2}$ in that it is a two-band superconductor in which the bands' contributions to the Fermi surface have very different topologies. We calculate $\ensuremath{\sigma}(\ensuremath{\omega})$ by calculating a memory function [W. G\"otze and P. W\"olfle, Phys. Rev. B 6, 1226 (1972)], which has been recently used to analyze $\ensuremath{\sigma}(\ensuremath{\omega})$ of ${\mathrm{Bi}}_{2}{\mathrm{Sr}}_{2}\mathrm{Ca}{\mathrm{Cu}}_{2}{\mathrm{O}}_{8+\ensuremath{\delta}}$. [J. Hwang et al., Nature (London) 427, 714 (2004)]. In our calculations, the two components of the Fermi surface are described by parametrizations of de Haas\char21{}van Alphen data. We use a phonon spectrum that is a fit to neutron scattering data. By including the momentum dependence of the Fermi surface, a good agreement is found with the experimentally determined strong-coupling features, which can be described by a broad peak at around $4.5\phantom{\rule{0.3em}{0ex}}\mathrm{meV}$ and a narrower higher peak at around $8\phantom{\rule{0.3em}{0ex}}\mathrm{meV}$ of equal height. The calculated features are found to be dominated by scattering between states within the third band. By contrast, scattering between states in the second band leads to strong-coupling features in which the height of the high energy peak is reduced by $\ensuremath{\sim}50%$ compared to that of the low energy peak. This result is similar to that in the conventional isotropic (momentum independent) treatment of superconductivity. Our results show that it is important to use realistic models of the band structure and phonons and to avoid using momentum averaged quantities in calculations in order to get quantitatively accurate results.


The Beauty and Joy of Computing (BJC) is a curriculum for the new AP Computer Science Principles course. Over the past 2 years, we have collected post-course surveys from 399 students participating in the BJC course. This paper investigates how the responses of females and students from underrepresented racial minority groups (URMs) differed from those of their counterparts. We found that female students had taken fewer CS courses prior to BJC but that students from URMs had taken more prior CS courses. Both groups were nearly equally likely to recommend the course to a friend, with about 80% recommending. We found no evidence to suggest that female students showed more or less interest in specific CS topics, such as learning how computing has changed the world or making mobile apps/games. Despite having taken more CS courses prior to BJC, we found that students from URMs were overall less likely to intend to take additional CS courses. Overall, our findings are fairly consistent with the literature, and suggest that BJC makes some progress towards broadening participation in computing.


Resource industry is the leading industry that promotes economic growth in the western ethnic-minority areas. The resource industry in the western ethnic- minority areas is encountering four challenges: the restructuring of China's total demand,the " resource curse" dilemma,the introducing of carbon tax,and ecological environmental degradation. In order to tackle the challenges and keep sustainable economic growth,the western ethnic- minority areas have to transform their developmental pattern for the resource industry and adjust industrial structure.


The experimental setup developed in Marseille for the laser damage testing allows a localized study. Indeed the use of a 25 micrometers for the waist of the focused beam, permits to de-correlate the extrinsic damage due to the micronic defects (visible under microscope) for the intrinsic ones (non-detectable before damage with conventional imaging systems). The probability of damage versus incident fluence is an S curve given in the range of two thresholds, SL and SH, the low and high damage thresholds. Most often the shape of probability damage curves are different between the intrinsic and the extrinsic cases. In our arrangement the beam size and the extrinsic defect size are in the same range, so by pointing at these visible defects it is possible to determine their specific threshold, and the density of defect is directly obtained from the optical image. Therefore a specific study of the intrinsic zones by pointing the beam at a zone free of extrinsic point, allows us to focus our attention only on these invisible defects. These particles are supposed to be nano-sized. The highlight and the identification of these nono-precursors is the aim of this paper.


One can find important and valuable contributions to Anthropology and theotokology in the homilies of the Holy Fathers and the Bzyantine theologians of the post-patristic period. Very often they contain important data concerning the genealogical tree of our Saviour Jesus Christ and His earthly ancestors. In this larger context, the Holy Fathers and other ecclesiastical writers disclosed their theological system and basic theological ideas. Among these, patriarch Photius the Great of Constantinople covers theotokology from two perspectives: christological and anthropological. He highlights an essential aspect: the creation of the first people, Adam and Eve, is an act that is essentially different from the ulterior propagation of the species in a natural way. This act of creation is not characteristic of nature, yet neither is it contrary to nature. Patriarch Photius calls this act a "work of the divine power" and refers to it as an event marked by the divine grace, as is the case of the extraordinary birth from a barren mother or from a virgin. In each case, something extraordinary has occurred, a miracle, which discloses the mystery of God"s creation.