Abstract In this paper, I argue that an embodied cognition theorist has resources available to her to fulfill the explanatory role of communicative intention without postulating inner, private intentions, as is typically done by cognitivists. I argue for this conclusion by identifying a publicity requirement and a sensitivity requirement that must be satisfied by realizers of communicative intentions a theoretical posit that explains the difference between linguistic meaning, as in John means cats are mammals by his utterance cats are mammals, and other sorts of meaning, as in that bell means the train doors are closing. I then show that a cognitivist model and an embodied model of communicative intentions can satisfy these requirements. However, because the embodied model is more theoretically parsimonious than its cognitivist competitor, the embodied model is superior. In the first section, I argue that communicative intentions exhibit the properties of publicity and sensitivity and that whatever satisfies the role of communicative intentions in a theory about cognition must also exhibit those properties. In the second and third sections, I present a cognitivist model and an embodied model of communicative intentions and show that each model exhibits the properties of publicity and sensitivity. In the fourth section, I argue that while both models equally explain the data, the embodied model does so more parsimoniously than the cognitivist model, and this gives us good reason to endorse the embodied model. Finally, I present an objection concerning explanatory power on behalf of the cognitivist and reply to it.


Total hip arthroplasty is the current treatment of choice for many hip diseases. With the increasing availability and success of total hip arthroplasty and the concomi tant treatment of TB infection, and better management of childhood hip problems, the number of surgical arthrodeses of the hip has declined. A limited number of hip fusions are still performed today for posttrau matic arthritis, unilateral osteoarthritis in the young, or as end-stage treatment for an infected hip. Unilateral hip arthrodesis can provide a stable, painless limb for am bulation and function. This was a common surgical treatment prior to the advent of hip arthroplasty. Patients with many years of excellent results from hip arthrodesis may develop related symptoms in other musculoskeletal areas. Callahan et aLl found 60% of hip fusions developed low back pain at an average of 25 years postarthrodesis. A similar percentage developed ipsilateral knee pain an average of 23 years postfusion. Ipsilateral knee instability was also found in 80% of the fused hip patients. Pain in the contralateral hip was found in 25% of people, developing an average of 20 years after hip fusion. Position of the fused hip plays an important role in the long-term outcome. Patients may develop sponta neous hip ankylosis after a hip infection or following traumatic injury. Abnormal positions of fusion can lead to severe functional disability. Most orthopedists agree that the ideal position of fusion for the hip is 30° to 40° flexion, 0° to 5° of external rotation, and 0° to 5° of ad duction. Callahan et aLl found a hip fused in abduction tended to have a greater risk for degenerative changes in the lower back and ipsilateral knee. Gore et aU eval uated the walking patterns of men with unilateral hip fusions. They found that absent hip motion is compen sated for by increased transverse and sagittal rotation of the pelvis, increased motion of the contralateral hip, and increased flexion of the knee throughout the stance phase on the fused side. These findings correlate with the clinical degenerative changes seen in the long-term studies by Callahan et aLl and Sponseller et al.,3 where the most commonly reported related pain was in the lower back, ipsilateral knee, and contralateral hip.


With the advent of microgrids (MG) and increasing use of renewable energy sources (RES), conventional low voltage networks change their structure from passive to active. The inherent oscillation nature of RESs, such as wind turbine units (WT), can lead to adverse effects such as power quality and system stability issues. therefore, the use of energy storage systems (ESSs) becomes one feasible solution to mitigate the output power fluctuations of the WT unit. In this paper, a Battery Energy Storage System (BESS) is used in order to smooth the power fluctuations based on a two-level control strategy include active power smoothing and reactive power compensation and also power management system. Various signal processing methods are applied to power smoothing level, and among all of them, the continuous wavelet transform (CWT) demonstrated the best performance. The effectiveness of the control strategy is verified using MATLAB/Simulink software.


Objective To investigate the expression of MUC15 in esophageal squamous cell carcinoma( ESCC) and its relationship with the occurrence and development of ESCC. Methods The mRNA levels and protein expression rates of MUC15 in 53 cases of normal esophageal mucosa tissue,20 mucosa tissue adjacent to cancer and 53 ESCC tissue samples were determined by RT-PCR and the SP immunohistochemical method,respectively,and the expression difference of MUC15 between different tissues was compared. Results The relative mRNA levels of MUC15 gene in the normal esophageal mucosa tissue,mucosa adjacent to cancer and ESCC tissue were 0. 281 ± 0. 017,0. 322 ± 0. 029 and 0. 790 ± 0. 038,respectively,and the protein expression rates 20. 7%,35. 0% and 88. 7%, respectively,with significant difference between different tissues( P 0. 05). In addition,the relative mRNA levels and protein expression rates of MUC15 in stages 0 ~ Ⅱ and Ⅲ ~ Ⅳ of ESCC were 0. 498 ± 0. 029,0. 832 ± 0. 045 and 70. 0%,93. 0%,respectively,with significant difference between them( P 0. 05). Moreover,there was also significant difference of relative mRNA levels( 0. 829 ±0. 031 vs 0. 501 ± 0. 042) and protein expression rates( 90. 2% vs 75. 0%) of MUC15 between ESCC with and without lymph node metastasis( P 0. 05). Conclusion The expression levels of MUC15 gene and protein in ESCC tissue are significantly higher than that in normal esophageal tissue,indicating that they may be associated with the carcinogenesis and development of ESCC.


It is widely accepted that thinkers can have thoughts involving concepts that, intuitively, they incompletely grasp. I argue, however, that the import of the phenomenon for the theory of linguistic and mental content has not been adequately appreciated: prominent theories of content, even if they specify modal determinants or grounds of content, lack an account of what it is for a representation to have content. The problem is easiest to see with respect to conceptual-role theories of content. And once we distinguish genuine incomplete understanding from mere error, we see that appeals to ideal conditions or a competence/performance distinction are no help with respect to incomplete understanding. Covariation theories are vulnerable to a parallel problem, for thinkers need not have a disposition to discriminate the relevant property in order to have the concept. An appeal to deference to other people cannot rescue conceptual role and covariation theories. A proviso about deference to others, understood in the most promising way, is a specification of an alternative way in which a representation's having content can be grounded, one that is inconsistent with the central position of conceptual-role and covariation theories about what it is for a representation to have particular content. Thus, those theories, once supplemented by an appeal to deference, lack a unified account of the phenomenon. In a companion paper, "Troubles for Content II: Explaining Grounding," I consider the response that it is enough for an account to specify different ways in which a phenomenon, such as a representation's having content, can be determined or grounded. I argue that such a specification leaves us without an understanding of why the phenomenon can be grounded in diverse ways and that, in general, an account of the nature of the phenomenon can explain its grounding.


An increasing number of sensors on mobile, Internet of things (IoT), and wearable devices generate time-series measurements of physical activities. Though access to the sensory data is critical to the success of many beneficial applications such as health monitoring or activity recognition, a wide range of potentially sensitive information about the individuals can also be discovered through access to sensory data and this cannot easily be protected using traditional privacy approaches. In this paper, we propose a privacy-preserving sensing framework for managing access to time-series data in order to provide utility while protecting individuals' privacy. We introduce Replacement AutoEncoder, a novel feature-learning algorithm which learns how to transform discriminative features of multi-variate time-series that correspond to sensitive inferences, into some features that have been more observed in non-sensitive inferences, to protect users' privacy. This efficiency is achieved by defining a user-customized objective function for deep autoencoders. Replacement will not only eliminate the possibility of recognition sensitive inferences, it also eliminates the possibility of detecting the occurrence of them, that is the main weakness of other approaches such as filtering or randomization. We evaluate the efficacy of the algorithm with an activity recognition task in a multi-sensing environment using extensive experiments on three benchmark datasets. We show that it can retain the recognition accuracy of state-of-the-art techniques while simultaneously preserving the privacy of sensitive information. Finally, we utilize the GANs for detecting the occurrence of replacement, after releasing data, and show that this can be done only if the adversarial network is trained on the users' original data.


A study of pre-germinated seed treatments with soaking, heating, chilling and its integration was conducted on two rice cultivar (viz. Prasad and Pant Sugandha Dhan-15) to explore the possibility of improvement in seed germination and seedling vigour under laboratory condition. The experiment comprised of six treatments and seeds were subjected with soaking, heating (40 °C), chilling (−20 °C), heating followed by chilling and chilling followed by heating after soaking for 24 h along with untreated control. Seed germination and subsequent seedling growth was greatly influenced by soaking, heating and chilling as indicated by statistically higher value of seed germination at first as well as final count and seedling vigour i.e. root, shoot and seedling length, fresh and dry weight of seedling, vigour index, relative growth index (RGI), germination index (GI) and mean daily germination (MDG). Soaking successfully integrated with heating followed by chilling and chilling followed by heating over untreated control for both the rice cultivars while, chilling solely had somewhat lower influence on rice seed invigoration.


ABSTRACT Extended-spectrum β-lactamase-containing Escherichia coli isolates were detected in 32 of 119 fecal samples (26.9%) from birds of prey at Serra da Estrela, and these isolates contained the following β-lactamases: CTX-M-1 (n = 13), CTX-M-1 plus TEM-1 (n = 14), CTX-M-1 plus TEM-20 (n = 1), SHV-5 (n = 1), SHV-5 plus TEM-1 (n = 2), and TEM-20 (n = 1).


The relationship between molecular weight distribution (MWD) and linear viscoelastic response of polymer melts was investigated with three commercial polymers and two blends (11 and 13 components, respectively) of nearly mono‐ disperse materials. Dynamic modulus master curves in the plateau and terminal zones were compared with predictions based on theoretically motivated combining rules, various descriptions of response for monodisperse melts, and the molecular weight distribution of each of the samples. Agreement with the Tsenoglou combining rule was excellent for the model mixtures, in which MWD was known by construction. Departures at low frequencies were found for the commercial samples, in which MWD was determined by size exclusion chromatography and light scattering. The discrepancy is attributed to uncertainties in the high molecular tail of distributions obtained by the dilute solution methods.


The paper measured the dynamic responses of the medium and low speed maglev track panels in action of the train and by this means obtained the natural frequency,dynamic stress,displacement dynamic coefficients and the bolt tension of the track panel.The results indicate that the phase-one and phase-two vertical vibration frequency stood at 9.088 Hz and 17.614 Hz respectively;while for the horizontal vibration frequency,6.426 Hz and 17.614 Hz.The coupling of the horizontal and vertical vibration was not caused by the torsional vibration;and no visible connection was found between the vehicle velocity and the stress changes either in the guideway or in the sleeper.However,within the velocity measured,the displacement dynamic coefficient goes up with the increase of the vehicle velocity.


For breakfast, try to e at foods from at least three or four different food groups, such as grains, fruits and the m ilk groups. Try these quick, easy and great tasting breakfast ideas: ▲ Oatmeal with apples auce and a glass of low-fat milk ▲ Ready-to-eat cereal with milk and fruit ▲ Peanut butter and b anana sandwich ▲ Bagel with cheese a nd 100 percent fruit juice ▲ Pita bread with yogu rt and strawberries Kids learn better if they eat breakfast!


In our society there is an increased awareness of environmental impact and reducing greenhouse gas emissions. An influencing factor is transport in passenger cars to and from work. In order to incr ...


The results of the International Atomic Energy Agency cross-section processing code verification project are described. This project has been conducted over the last 7 yrs in an attempt to improve the reliability of the results produced by cross-section processing computer codes. Initial comparisons of results received from 42 participants using 13 different cross-section processing codes demonstrated that, even though all of the codes started from exactly the same evaluated data, in no case did the multigroup cross sections calculated by any two codes agree for al materials and groups used in the comparison. This code verification project has led to positive results by improving cross-section processing codes as well as the conventions used to interpret ENDF/B evaluations. In several cases it has led to changes in ENDF/B evaluations. Although this project only addressed nuclear data processing codes, conclusions can be drawn from the results regarding the reliability of other types of computer codes.


The system scheme and type selection of main equipments of the building integrated photovoltaic project for Huadian Industrial Park were introduced.The key design of the system was analyzed.The emphasis of building integrated photovoltaic system design was put forward.


A practical methodology for defining the required characteristics of sets of stationary and non-stationary test-signals for benchmarking the performance of modal-estimators is described along with the assessment criteria. The algorithm for the modal-estimator assessed in this paper is used in the Australian National Grid for system damping performance and model calibration. The efficient computational methods used to generate the test-signals are described and are based on detailed models of the operator's own system. The benchmarking methodology has been applied in practice to rigorously and independently assess the relative performance of a number of practical modal-estimators. As a result the system operator is able to identify the key strengths and limitations of the various modal-estimators for their own system and apply the appropriate estimator to the desired application, i.e. short-term or long-term estimation. The set of generated test-signals has proved to be of benefit to the developers of modal-estimators as they endeavour to improve their estimation algorithms.


It is pointed out that Hantush's \emph{M} function, commonly used in groundwater pumping modeling, is identical to the function known in the problems of heat conduction in the ground. A modified Hantush function $E$ used in the steady-state solutions for heat conduction that take into account advection due to groundwater flow around borehole heat exchangers (BHEs) is introduced. New exact representation and two-types of approximate expressions for this two-parametric function \emph{E} are presented: one is suitable for small values of a parameter and the other for its large values. High accuracy of the approximate formulae is verified by comparison with the exact values provided by modified Hantush's function $E$ in those validity domains. These analytical expressions can be used for designing complex borehole configurations and may be potentially useful in steady-state analysis of partially penetrated wells (PPWs) in leaky aquifer.


The effects of metronidazole, which selectively sensitizes hypoxic cells, on the radiation response of C3H mouse mammary carcinoma and of mouse skin and jejunal epithelium have been investigated. A dose of 2.5 mg of metronidazole/mouse reduced the TCD50 from a control value of 6,360 rads to 5,310, 5,310 and 5,400 rads, at 3, 10 and 30 minutes after i.v. injection, respectively, in mice bearing tumors 8 mm in diameter. The skin response, as measured by the DD50, was also enhanced by metronidazole, the control value being 4,780 rads, compared to 3,980 rads in metronidazole-treated mice. The jejunal epithelium, however, was not sensitized by metronidazole, but conversely, a slight protective effect was observed at high radiation doses. This dose of metronidazole had no effect on tumor growth rate and was not toxic to the mice.


This paper reports on an aspect of a small, empirical study that explored how cross-category friendships were constructed among an ethnically diverse cohort of Year 10 students in an Australian school. The students, who self-identified as having friendships across gender and ethnic boundaries, were interviewed in focus groups. Young men and young women, in speaking of their cross-cultural friendships, generally stressed commonalities among rather than differences between groups of friends. Nevertheless, students identified two predominant peer groups and used the terms 'aussie' and 'wog' to name them. Some of the male students appeared to be more keen than many of the females to mark themselves out as belonging to one or the other of these groups. This paper will discuss how these terms are utilised among these students to construct particular identities. On one level, this naming signified differences of choice, with reference to styles of music, clothing, jewellery, hair and entertainment. Is this an attempt to reclaim and rework previously racist descriptors into more egalitarian terms by young people? The meanings and sense that students make of such traditionally racist terms and how their use reflects and challenges wider cultural discourses of difference are discussed. How 'sameness' is constituted around shared experiences rather than common cultural backgrounds is also considered.


Objective
To investigate the effects of interleukin (IL)-34 on the proliferation and chemokines expression of fibroblast-like synoviocytes (FLS) in patients with rheumatoid arthritis (RA).

Methods
RA FLS were isolated and cultured in the presence or absence of IL-34. FLS proliferation was determined by methyl thiazlyl tetrazoliu method (MTT) method. The levels of chemokines from RA FLS supernatant were detected by protein chip AAH-CYT-G1000 assay. The IL-34 receptor (IL-34R) expression on RA FLS was analyzed by flow cytometry (FCM). Statistical analysis between groups was performed by t test.

Results
Compared to the control group, the proliferation of IL-34-stimulated RA FLS was obviously increased, and up to the maximum at 72 hours. In addition, the levels of chemokines [epithelial neutrohil-activating peptide 78(ENA-78), IL-8, growth-related oncogene (GRO), macrophage chemoattractant protein-1 (MCP-1)] on RA FLS supernatant in IL-34 stimulated group were significantly elevated than those in the control group [ENA-78: (397.1 ±8.2) pg/ml, (54.0±2.9) pg/ml (t=127.61, P<0.01); IL-8: (2 017±36) pg/ml, (778±102) pg/ml (t=36.67, P<0.01); GRO: (4 935±160) pg/ml, (2 746±188) pg/ml (t=43.60, P<0.01); MCP-1: (46 798±1 293) pg/ml, (27 813±2 329) pg/ml (t=22.43, P<0.01)]. IL-34R was highly expressed on the RA FLS.

Conclusion
IL-34 promotes RA FLS proliferation and chemokines expression, which may be one of the important mechanisms involved in the pathogenesis of RA.

Key words:
Arthritis, rheumatoid; Fibroblasts; Interleukin 34; Chemotactic factors


An electronic elimiating rotation method based on mathematic platform is put forward,which can be used on image rotation by carrier perturbation when the video theodolite tracks target on the active pedestal. The hardware system with strapdown inertial navigation equipment,DSP and FPGA,can elimate rotation and fill the image by reverse rotation and bilinear interpolation.This system developed has successfully applied in minitype shipboard theodolite,can complete the restoration of 720×576×24 color video image,and achieve frame frequency with 25 frame/s for one fine quality image and less then one pure pixel level of maximum pixel error.


This paper presents the nonlinear characteristics of the parametric resonance of a simply supported beam which is inextensible beam. For the beam model, the order-three expanded equation of motion has been determined in a form amenable to a perturbation treatment. The equation of motion is derived by a special Cosserat theory. The method of multiple scales is used to determine the equations that describe to the first-order modulation of the amplitude of simply supported beam. The stability and the bifurcation points of the system are investigated applying the frequency response function.


The viewpoint space of 3-D objects,such as aircraft,automobiles,and humans is partitioned using three affine invariant features based on a multi-scale autoconvolution,a trace transform,and the Zernike moment to express the 3-D objects within minimum two-dimensional projective images.The images are then nonuniformly projected for object recognition to simplify the 3-D recognition process and increase the recognition rate of 3-D objects.The paper presents an affine invariant feature extraction strategy for different 3-D objects that can recognize arbitrary postures of the 3-D object.Tests with models from the Princeton shape benchmark show that the good recognition effect can be achieved by the proposed method and the recognition rate is great than 90%.


The photosystem(PS) II of higher plants is prone to light-induced inactivation,the D1 protein being the primary target of such damage.As a consequence,the D1 protein,encoded by the psbA gene,is degraded and re-synthesized in a multistep process called PSII repair cycle.In chloroplasts of Chlamydomonas reinhardtii the psbA gene expression was strongly regulated by mRNA processing,and particularly at the level of translation initiation.Light was proposed to stimulate the translation of chloroplast psbA mRNA by activating a protein complex associated with the 5' untranslated region of this mRNA(RNA-binding protein,RBP).The protein complex contains a redox-active regulatory site responsive to thioredoxin.The author summarized the turnover of the photosystem II D1 protein and the progress of researches on regulatory mechanism of photosystem II D1 protein expression at the levels of transcription,translation.


Following Edward Snowden's revelations, end-to-end encryption is becoming increasingly widespread in messaging tools—solutions that propose a large variety of ways to conceal, obfuscate, disguise private communications and online activities. Designing privacy-enhancing tools requires the identification of a threat model that serves to agree upon an appropriate threshold of anonymity and confidentiality for a particular context of usage. In this article, we discuss different use-cases, from "nothing-to-hide" low-risk situations to high-risk scenarios in war zones or in authoritarian contexts, to question how users, trainers, and developers co-construct threat models, decide which data to conceal, and how to conceal it. We demonstrate that classic oppositions such as high-risk versus low-risk, privacy versus security, should be redefined within a more relational, processual, and contextual approach.


In order to improve the management and monitoring of water environmental protection, monitor system of water quality based on embedded system (TPC-1260) is presented in the paper.By using Unified Modeling Language to model software and Object-Oriented programming language (EVC) to design software,the system is rationally structured, highly cohesive, loosely coupled, easy to maintain and extend. The department of environmental management can master the situation of water quality of important water area and predict water pollution accident through application of this system.


Active sequences from the laminin (cid:97) 1 and (cid:97) 2 chain carboxyl-terminal globular domains (G domain) have been identified by screening overlapping synthetic peptides in a number of biological assays (Nomizu et al. [1995] J. Biol. Chem. 270:20583–20590; Nomizu et al. [1996] FEBS Lett. 396:37–42). We have tested the activity of these pep-tidesinsubmandibularglandexplantsofembryonicday13micetodeterminethefunctionalsitesin-volvedinorgandevelopment.Thelaminin (cid:97) 1 chain peptide, RKRLQVQLSIRT (residues 2719–2730 and designated AG-73), significantly inhibited epithelial branching morphogenesis. In contrast, other cell adhesive laminin (cid:97) 1 chain peptides including the AASIKVAVSADR and NRWHSIYITRFG failed to inhibit the branching. MG-73, a homologue of AG-73 fromthelaminin (cid:97) 2chain,didnotinhibitthebranch-ing. The (cid:97) 2 chain peptide had no effect, which may be due to the low levels of this laminin chain in day 13 mice. Laminin (cid:97) 2 chain-specific monoclonal antibodies strongly reacted with the basement membranes of developed acini but only weakly stained embryonic day 13 submandibular epithelium. The expression of E-cadherin and (cid:97) 6 integrin, as de-tected by immunofluorescence, were unchanged in both AG-73 and control scramble peptide-treated epithelial cells of the explants. In contrast, immunostaining of nidogen/entactin showed that explants treated with AG-73 for 3 days had a discontinuous basement membrane. Explants treated for 3 days with control peptide showed a normal basement membrane. These results suggest that the region containing the AG-73 sequence of the laminin (cid:97) 1 chain is crucial for development of submandibular gland at early embryonic stages. The discontinuous basement membrane inAG-73-treated explants may indicate an important role for this region in basement membrane assembly. Dev. Dyn. 1998;212:394– 402. r 1998Wiley-Liss,Inc.


The modeling of HIP has been studied for more Hian 30 years.The purpose of modeling is optimization of HIP for material saving,ruduction of finishing with cost reduction of near-to-shape or final products.Three approaches of HIP modeling are reviewed with description of 4 types modeling of HIP technologies.The experimental examination of Ashly HIP 6.0 model is introduced.


Considering the growing presence of non-gaming amenities in a mature casino market such as the Las Vegas Strip, this study examined the relationship between entertainment and casino-operated restaurant revenues. Using the internal data of a Las Vegas hotel casino, this research found a statistically significant and positive relationship between daily show headcounts and restaurant revenues. This finding seems to imply that customers attending shows are likely to patronize restaurants in the casino on the same trip. The positive relationship between entertainment and restaurant business volumes suggests that casino executives should consider leveraging show traffic with additional revenue-enhancing venues such as restaurants in order to optimize property cash flows.


Severely handicapped people need to make efficient use of head movements to control assistive technology, especially when fine motor control of hand function is poor. A remote video system has been used to record head movements during the performance of a simulated direct selection task. Results for one non-handicapped subject are considered in detail and compare well with those given in the literature. The implications for assistive technology control will be discussed.


Biorefineries are facilities for the production of fuels and chemicals from biomass, which can tackle the increasing emissions of carbon dioxide. In this paper, we formulate a systematic biorefinery process synthesis problem with the goal of finding which of these products and process technologies result in a biorefinery with the highest economic potential or carbon efficiency. Our approach allows for the explicit evaluation and comparison of different biorefinery configurations. We also aim to investigate the relationship (and competition) between chemicals and fuels production. We initially develop a biorefinery superstructure and formulate a mixed integer nonlinear program which we solve for the optimal biorefinery configuration. We present sensitivity analyses with respect to changes in product prices and feedstock costs which allows us to better understand how the optimal configuration responds to changing economic conditions. We present a Monte Carlo type sampling of these parameters which indicates...


In the paper the authors study text sentiment analysis. The research reviewed the existing methods for sentiment analysis. This analysis showed that the most frequently used for this purpose methods of machine learning (such as support vector machines) and classification by linguistic rules. For this reason, the authors decided to combine machine learning based on the statistical properties of the words and linguistic rules. The paper considers a method of sentiment analysis, based on a probabilistic model of the occurrence of words in documents. It proposes to extend this model through consideration of the semantics of words. For the method study, the authors used three collections provided by the organizers ROMIP: reviews of movies, reviews of books from site imhonet.ru, reviews of cameras from Yandeks. Market. The method was further tested on a collection of blog posts provided ROMIP. The research showed that the generalized method based on statistical and semantic properties of the words occurrence in a document provides a fairly accurate assessment of sentiment text analysis.


The invention discloses a polyurethane reinforced plugging agent for coal beds, which consists of a component A and a component B, wherein the component A consists of a polyether glycol, a chain extender, a fire retardant and a catalyst; and the component B consists of a prepolymer of polyether glycol and isocyanate. The plugging agent can be used by uniformly mixing the component A and the component B in a volume ratio of 1:1, pouring the mixture into the coal beds and allowing the mixture to solidify. The component A and the component B reacts at normal temperature, so energy is saved and heating equipment is not required. The reaction speed is high, the reaction temperature is low, the fire resistance is high, the flowability is high, the adhesive property is high, waste gas, liquid and solid are avoided, and product quality is stable. The plugging agent is very suitable for reinforced plugging of coal beds in coal mines.


A vacuum relief system for a fuel tank is provided to save necessity of dedicatedly supplying makeup air for compensating a vacuum in a steam space of the fuel tank by maintaining an opened state of a vacuum-relief controller even after the air in the fuel tank is removed. A vacuum relief system for a fuel tank(16) is adopted to a filler neck cap(12) that comprises a closure, a vacuum relief controller, and a maintaining unit. The closure is connected to a filler neck(14) to close an opening of the filler neck, and includes a vent hole opened to the ambient air. The vacuum relief controller moves with respect to the closure. More specifically, when pressure in the filler neck drops to be lower than a predetermined atmospheric pressure, the vacuum relief controller moves from a closing position that interrupts an airflow through the vent hole, to an opening position that allows the airflow. Even after the pressure in the filler neck increases to be greater than the predetermined atmospheric pressure, the vacuum relief controller stays in the opening position to allow flow of the air and fuel steam through the vent hole.


« Intellectual property » extends far beyond culture to essential aspects of life for populations around the world, such as health or food. Many activists have chosen to defend society's interests against the temptations of control. Thanks to a flexible and global coordination strategy they have turned the question around : since access to knowledge for all persons is necessary, how can we make it happen?


The article analyzes the design tactics of the Ali Apple Elementary School in Tibet, of its materials, walls, grouping, units, colors and landscape, etc. It also presents its design measures, such as harmonizing buildings with nature, creating spatial relationship to enrich children's experiences in the buildings, and adopting simple artifices to bestow regional characteristics to the buildings.


Mycoplasma pneumoniae was examined for growth characteristics and morphology when cultivated in several media supplemented with a variety of sera and under different atmospheric conditions. different formula of the medium as well as different sources of lot numbers of the serum in the same medium ex...


ABSTRACT The RNA export adaptor protein Rec, encoded for by the human endogenous retrovirus HERV-K/HML-2 elements, binds to the Rec responsive element (RcRE) located in the 3′ untranslated region of HERV-K/HML-2 transcripts. Binding allows the nucleocytoplasmic export of unspliced viral RNA, thereby overcoming host restriction. Chemical probing of the secondary structure of the RcRE corroborated the theory that the RcRE forms a complex folded structure with seven stem-loop regions. Laser-induced liquid beam ion desorption mass spectrometry revealed that Rec forms stable tetramers, which are further stabilized upon RNA binding. The RNA protein complex consists of three Rec tetramers, which bind to multiple sites on the RcRE—preferentially to purine-rich motifs—which represent several low-affinity binding sites. Mutated RcREs, with one to three purine-rich motifs deleted, were still bound and exported by Rec, indicating that the complex folded structure of the RcRE is important for Rec binding. This suggests a binding model where up to three Rec tetramers bind to the complex folded structure of the RcRE and the binding seems to be tightened by recognition of the purine-rich motifs.


In the QCD factorization (QCDF) approach we study the direct $CP$ violation in $\bar{B}^{0}\rightarrow\rho^0(\omega)\rho^0(\omega)\rightarrow\pi^+\pi^-\pi^+\pi^-$ via the $\rho-\omega$ mixing mechanism. We find that the $CP$ violation can be enhanced by double $\rho-\omega$ mixing when the masses of the $\pi^+\pi^-$ pairs are in the vicinity of the $\omega$ resonance, and the maximum $CP$ violation can reach 28{\%}. We also compare the results from the naive factorization and the QCD factorization.


In October 2007, the semi-submersible platform PETROBRAS 52 (P-52) was installed in Campos Basin (Roncador Field) offshore Brazil. This Unit is moored through 16 lines in taut-leg configuration in a water depth around 1.800m. Its displacement at the operational draft (T = 27.5m) is 80.986t. The maximum production capacity is 180.000bpd. During the design phase of this floating system, a model test campaign was performed in a wave basin and slow drift motions in the vertical plane (heave, roll and pitch) were identified. It is known that resonant responses vary considerably with the damping loads. As these loads are affected by scale effects, by that time, it was a doubt if this phenomenon would happen during the platform operation. Since June 2008, PETROBRAS has been monitoring P-52 motions with the use of accelerometers and rate-gyros. Through spectral analysis of the measured signals, it was possible to verify the presence of slow motions with frequencies around the natural frequencies of roll and pitch during almost the whole monitoring period. Sometimes, the 2nd order amplitudes were even grater than the 1st order ones. Furthermore, the environmental conditions have also been monitored through wave radars, ADCPS (current) and meteorological stations (wind) in the vicinity of P-52 location, making the excitation loads identification possible. A comparative study confronting full-scale measurements and theoretical predictions was performed. First and second-order forces and responses were calculated using WAMIT® second order module. This study permitted to estimate the full scale damping values of this offshore system (hull plus mooring and riser lines) for one of the environmental conditions measured. This work demonstrates the importance of considering the resonant roll and pitch motions in the seakeeping analysis of large-volume semi-submersible platforms, contributing with an important feedback to future designs.Copyright © 2010 by ASME


It is only through close spacecraft encounters that cometary nuclei can be resolved and their properties determined with complete confidence. At the time of writing, only two nuclei (those of Comets 1P/Halley and 19P/Borrelly) have been observed, both by rapid flyby missions. The camera systems onboard these missions have revealed single, solid, dark, lumpy, and elongated nuclei. The infrared systems gave surface temperatures well above the free sublimation temperature of water ice and close to blackbody temperatures. The observed nuclei were much more similar than they were different. In both cases, significant topography was evident, possibly reflecting the objects' sublimation histories. Dust emission was restricted to active regions and jets in the inner comae were prevalent. Active regions may have been slightly brighter than inert areas but the reflectance was still very low. No activity from the nightside was found. In this chapter, the observations are presented and comparisons are made between Comets Halley and Borrelly. A paradigm for the structure of cometary nuclei is also described that implies that the nonvolatile component defines the characteristics of nuclei and that high porosity, largescale inhomogeneity, and moderate tensile strength are common features.


This first book to address the most urgent issues combines a solid research approach with applied individual and stress issues. It focuses on our latest knowledge of various causes of stress and it ...


The concept of discretion in public administration basically brings significant positive energy when viewed in the perspective of virtue for the morality-based governance (law). Government as the holder of discretion power holds an important power, yet not for itself. In this way, in exercising discretion, government not only may take actions out of the specific prescription in the law, but also may take actions contradicting the law for common good. Such actions are justifiable as long as they are intended for public interest and public good; not for the sake of itself. Such action cannot be blamed within public administration, as long as the purpose is in accordance with the purpose of the state's constitution for common good and prosperity.


The present invention relates to transdermal delivery dihydropyridine calcium antagonists for treating hypertension delivery device through the skin. The apparatus comprises a backing layer and an adhesive matrix reservoir. The adhesive matrix reservoir is fixed on one side of the backing layer, it may comprise a dihydropyridine type calcium antagonist and at least one fatty acid permeation enhancer.


Tyrosine hydroxylase deficiency (THD) is a recessive autosomal hereditary disease that blocks the transformation of tyrosine into levodopa, resulting in dystonia and parkinsonism in children (OMIM #605407). Treatment consists of L-dopa, which has variable efficacy. In Parkinson's disease (PD) patients, a protein-redistribution diet (PRD; normal protein content, including both animal and vegetable proteins, exclusively for dinner) may reduce the competition between L-dopa and dietary amino acids. We report on the case of a patient with THD whose response to L-dopa improved significantly with a PRD and the consumption of special low-protein foods (LPP).


The reinstatement of third-party collateral has not received much academic attention to date. Previous treatment of this issue has, in relation to many questions, merely led to seemingly apodictic assertions, without taking each systematic, historical context into account. This work provides coherent, dogmatically well-founded reasoning with respect to this set of issues. It scrutinizes prior approaches to this, in particular the differentiation between accessory and non-accessory collateral, resolves issues that have been disputed to date and provides a viable, dogmatic solution.

In conclusion, possible contractual solutions are outlined which, contrary to previous approaches, except for tax and accounting law issues, protect the collateral taker as far as possible against good faith acquisition by third parties and can stand up to the strict case law relating to "restrictive security agreements".

This work is aimed at both practitioners and academics.


Shaped brick made of concrete, which are customary for the production of concrete components and aggregates photoluminescent phosphor pigments are added, characterized in that the luminescent pigment is a strontium aluminate, and the molded brick having a composition of 20 to 30 wt .-% fluorescent pigment, 8 to 30 weight % white cement and 10 to 60 wt .-% 0/2 mm quartz sand.


Alzheimer's disease (AD) is a neurodegenerative disease, which endangered human life expectancy. Since 2020, approximately 50 million people worldwide had got AD. With the increase of longevity of the whole population, the potential threat of AD Also increase. Although the pathogeny of AD is still not entirely clear, there have developed several hypotheses for AD. One of them is Aβ hypothesis. It suggests the deposition of Aβ plaques outside the neuron cells. This may cause a series of problems. It may induce ER stress, oxidative stress, neuro-inflammation and inhabited LTP in patients' hippocampus. These all stimulate the neuron cell death. The loss of neuron cells will further induce these symptoms and then triggered the loss of memory. Although there are still a lot of debates on the now existing drugs about AD, the further studies on the role of Aß on AD is needed.


The total RNA extracted from local isolated H9N2 avian influenza virus (A/chicken/Mu dan jiang/0823/2000) was used as the template in this study, a piece of universal primer and a pair of specific primer were designed for RT-PCR to amplify the HA gene. A specific 1707 bp cDNA product was obtained, which encodes 560 amino acid residues, and the uncleotide homology with H9N2 subtype publicized in Genbank was between 99% and 87.23%. Furthermore, the homology was between 98.04% and 88.57% at amino acid level, and the amino acid sequence of HA cleavage site indicated that CMJ/00 strain had low virulence.


The U.S. Environmental Protection Agency (EPA) is taking a closer look at the health or environmental impact of pharmaceuticals and personal care products that get flushed down the toilet. Earlier this month, the agency asked for public comment on its plans to collect data from hospitals and nursing


Book synopsis: In this Festschrift, Nicolai Rubinstein is honoured by members of his seminar in Italian history at the Institute of Historical Research, covering a period of 40 years. Following the traditional form of the seminar, contributions, which are grouped under thematic headings, focus on the interpretation of archival documents.


Power quality monitoring has advanced to an important tool for system evaluation and solving power-related problems. As a consequence the increased amount of recorded data requires more sophisticated analysis methods. The paper proposes a system for automated recording and classification of power quality disturbances. The system features statistical classification techniques applied to a frame-based event model. Results and experiences made by a test in a low-voltage power system are presented. Keywords— Classification system, field test, power quality, power quality monitoring.


This paper used a multi-level latent class model to evaluate whether online learning patterns exhibit regional differences and demographics. This study discovered that the Internet learning pattern consists of five segments, and the region of Taiwan is divided into two segments and further found that both the user and the regional segments are highly interpretable. The individual segments are dictated by demographic variables, such as age and gender. For instance, younger people were good at employing Internet services; those 21-30 years old adopted e-learning, browsed blogs, and enjoyed the Internet more than others; and females preferred e-learning applications more than males did. On the other hand, the regional segments are dictated by the individual segments. For instance, the service area segment comprised a higher proportion of members who were good at online learning applications. The agricultural area segment made up a higher proportion of members who were traditional users. The findings provide both product or service providers/vendors and curriculum designers with an applicable guideline for developing service strategies for better matches and higher service satisfaction between the curriculum and the users' needs.


SYNOPSIS

The validity of six species of British Collembola is discussed. Three species of Anurida and two of Anuridella are regarded as junior synonyms. Confirmation of an earlier synonymy in Anuridella is provided.


Objective:To study the rule of extracellular matrix (ECM) in diagnosing left ventricular hypertrophy in hypertension (EH), also to study the infleunces of transforming growth factor β 1 (TGF β 1), angiotension Ⅱ(AⅡ), aldosterone (ALD) on ECM.Methods:To detect plasma pre collagen carboxylit end peptide I(PICP), pre collagen amino and peptid Ⅲ (PⅢAP), TGF β 1, AⅡ and ALD?and to calculate left vertvicular mass index (LVMI) in 47 patients with EH and in 26 normal subjects. Results:PICP, PⅢAP, TGF β 1, AⅡ and ALD were much higher than that in normal subjects, especially in LVH patients. The levers of TGF β 1, AⅡ and ALD were corelated with the levels of PICP and PⅢAP.Conclusion:ECM has great value in diagnosing LVH in EH.


ABSTRACT We claim that venting can be epistemic work: if one vents to the right sort of person, knowledge can be gained about an oppressive social structure, one's place in it, and how to repair the epistemic damage it creates. To justify this claim, we define both epistemic damage and venting, and contrast venting with related notions such as complaining and ranting. Using Code's understanding of testimony, Dotson's notion of a linguistic exchange, and Fricker's distinction between testimonial and hermeneutical injustice, we describe when and how venting is epistemic work. We also discuss the way venting is distinct from consciousness raising. We conclude that although one goal of venting is to repair epistemic damage for individual women, venting's positive epistemic impact prepares women to challenge hermeneutical injustice.


Aim: to analyze the meaning of leprosy for 28 women who were diagnosed with this disease and under medical supervision in an infectology service located in Petrolina, Pernambuco, Brazil. Method: the data were collected through individual interviews and its processing happened in virtue of content analysis technique. Results: the verbal reports revealed that the disease caused changes in daily life in familiar, professional and economic aspects. The disease also affected the body image that women had about themselves, which indicated that prejudice is still present in social and familial relations. Multidrug therapy was seen as something positive, but it caused much discomfort and some women did not feel really cured at the end of the treatment. Conclusion: Leprosy affects the lives of women in different aspects and economically disadvantaged people are more vulnerable to the disease.


Terahertz intersubband lasers based on different optical transitions are investigated under an intense magnetic field applied perpendicularly to the plane of the epilayers, reaching the limit where the cyclotron energy exceeds many times the photon energy. Lasing thresholds as low as $0.65\phantom{\rule{0.3em}{0ex}}\mathrm{A}∕{\mathrm{cm}}^{2}$, together with a strong increase of the laser efficiency demonstrate the long intersubband relaxation times achieved in the intrawell samples by the induced three dimensional confinement. The radically different behavior observed for the bound-to-continuum structures highlights the role of interface roughness scattering at low energy subband spacing.


Kidney transplant recipients may have pre-transplant alloantibodies or develop de novo anti-HLA and non- HLA antibodies after transplantation. Although these antibodies may be donor-speci fi c or non-donor-speci fi c, their presence may increase the risk for acute and chronic rejection, thereby decreasing allograft survival. The introduction of high sensitive and speci fi c methods to detect anti-HLA antibodies, both before and after trans- plantation, will help to de fi ne transplant recipients who might be at increased risk for early or late allograft failure. Moreover, knowledge of alloantibody status before transplantation may help to guide the appropriate use of immunomodulatory agents and plasmapheresis to remove anti-HLA antibodies or downregulate their production. The review focuses on the associations between renal graft outcome and pre-transplant and de novo alloantibodies.


Survival of female rats exposed to a lethal dose of total-body X-radiation has been achieved by postirradiation parabiosis with a "normal" partner (1, 2), even when the latter has had ablation of the adrenals, kidneys, spleen, or hypophysis (3, 4; Finerty and Binhammer, unpublished data). Regeneration of the damaged hematopoietic and lymphoid tissues is hastened in the irradiated animal (5), presumably as a result of the large exchange of blood between the parabionts (6). There is evidence that the protective factors may be related to the increased leukocytes of the partners, originating in the nonirradiated (normal) partner, and attention has been directed especially to the activity of the neutrophiles in this respect (7). If leukocyte suppression in the normal parabiont were possible by some means other than irradiation, then this partner should not be able adequately to protect the irradiated one. If, in addition, selective depression of the neutrophiles could be accomplished, the relative role of neutrophiles and lymphocytes might be evaluated better in the protective mechanism.


We analyze the phenomenology of a set of minimal supersymmetric standard model (MSSM) soft terms inspired by flux-induced supersymmetry (SUSY)-breaking in Type-IIB string orientifolds. The scheme is extremely constrained with essentially only two free mass parameters: a parameter M, which sets the scale of soft terms, and the μ parameter. After imposing consistent radiative electro-weak symmetry breaking (EWSB) the model depends upon one mass parameter (say, M). In spite of being so constrained one finds consistency with EWSB conditions. We demonstrate that those conditions have two solutions for μ 0. The parameter tan β results as a prediction and is approximately 3–5 for one solution, and 25–40 for the other, depending upon M and the top mass. We examine further constraints on the model coming from b→sγ, the muon g−2, Higgs mass limits and WMAP constraints on dark matter. The MSSM spectrum is predicted in terms of the single free parameter M. The low tan β branch is consistent with a relatively light spectrum although it is compatible with standard cosmology only if the lightest neutralino is unstable. The high tan β branch is compatible with all phenomenological constraints, but has quite a heavy spectrum. We argue that the fine-tuning associated to this heavy spectrum would be substantially ameliorated if an additional relationship μ = −2M were present in the underlying theory.


The article considers the prospects and the effects of the implementation of major coal projects. The implementation of coal projects in the East of the country, will certainly lead to a significant increase in GRP regions, filling the regional budgets and the creation of new jobs.


In England the debate over faith schools bears analogy to the debate currently raging in the United States over higher education institutions. Does a democratic society gain or lose by having faith-based universities and schools? Do such institutions add something that is quite unique and vital to the life of the whole community? And do those teaching in our educational establishments (be they faithbased or not) actually teach differently, both methodologically and in terms of content, if they are religious? This book addresses all these questions, mainly in a positive mode. Those familiar with the current US debate will not find much that is new or groundbreaking in terms of theory. The book's greatest merit is its accessibility, its coverage of a wide range of issues, its practical testimonies, its interdisciplinarity and ecumenical range. For all this, it is to be greatly commended. It is divided into three parts. The first concerns foundational issues and is devoted to the general questions underlying religiousbased institutions. All the essays are excellent. Good orientation is found in Nicholas Wolterstorff's charting how the philosophy of science has developed so that the notion of neutral objectivity has given way to a recognition of differing and particular starting points. Historically, this resulted in a curious turn such that religiously based scholarship is now methodologically acceptable in the 'secular' university. Alan Wolfe elegantly charts three options that can be taken by such faith-based institutions: sectarianism with little interaction, parallel traditions, also somewhat insular, or pluralism whereby different groups are committed to dialogue and exchange. Wolfe's piece is stimulating and eirenic. Perhaps the essay that stands out most is that of David Hollinger, for it represents the sole voice of real protest within this volume. He argues that the American academy has fought hard for its intellectual independence from religion, and religion is everywhere in America, so the academy should exclude it for academic freedom to flourish. Part II examines religion and scholarship from different disciplinary perspectives and makes for engaging and rich reading.


The hybrid General and Organic Chemistry courses have been designed to promote the development of students' cognitive ability and confidence in utilizing chemical concepts. The approaches used could have utility in other courses focused on integrating skill development with critical thinking and reasoning. Data has been collected from more than 150 students over 3 years. The courses highlight: An integrated peer learning structures with mediated learning strategies that extend beyond the classroom through question & answer blogs and online office hours. Rubrics and grading checklists used to evaluate students' competencies and approaches to problem solving. Assessment of students' perceived value of course activities to their mastery of content. Analysis of student learning outcomes in courses using flipped methods to those utilizing traditional methods for content delivery. Presented here is an overview of the technology enabled approach. The presentation highlights the learning outcomes, perceptions, and motivation of two cohorts that were maintained throughout General Chemistry 1 & 2 and Organic Chemistry I: those beginning the General Chemistry course sequence in Fall 2012 (cohort 1) and Fall 2013 (cohort 2). Acknowledgement This investigation has been funded in part by a grant from the National Science Foundation HBCUUp Targeted Infusion Project Award No. HRD-1332575 and the HHMI Undergraduate Education Program Award #52007559. Outcomes for General Chemistry Concept Mastery Student mastery of course content was measured using the standardized final exam, 2010 first term Organic Chemistry exam from the American Chemical Society. Values represent the number of correct responses out of 58 questions (standard deviation): National Average = 32.64 questions (9.73) Average across all sections = 27.08 questions (10.79) Average for sections using blended learning = 29.75 questions (11.70) In 2014, there appears to be a significant improvement in learning outcomes in comparison to those in 2013. The most notable gain in knowledge relates to naming organic structures for 2014 (based on pre and post knowledge). Below is a summary of student performance by concept. Cohort 1 = Flipped 2013, cohort 2 = Flipped 2014. The score represents the average number of correct responses per number of questions in each category (standard deviation). Outcomes for Organic Chemistry Format of Flipped Courses The flipped General and Organic Chemistry courses utilized complimentary pedagogy (shown below) that is largely technology driven. Students: The same population of students matriculated through both the General Chemistry two semester sequence and the first semester of Organic Chemistry with the exception of those lost due to attrition. The students were primarily chemistry and biochemistry majors. Course Size: Course size in General Chemistry were capped at 40 and at 30 for Organic Chemistry. 0 10 20 30 40 50 60 F09 S10 F10 S11 F12 S13 F13 S14 Av er ag e Te st S co re s Semester for General Chemistry 1 (F) & 2 (S) Sec1 Sec2 Sec3* Average ACS Final Exam Raw Scores – 4 Academic Years Students' mastery of concepts was measured using standardized American Chemical Society (ACS) exams as course final exams. The General Chemistry I (fall term, F) courses used the 2002 first term General Chemistry exam and the General Chemistry II courses (spring term, S) used the 2003 comprehensive General Chemistry exam. It was found that final exam scores improved upon implementation of the blended courses as compared to the traditional lecture courses. The graph below shows average test scores out of a possible 70 correct responses. National averages are 41.73 and 41.03 for the fall and spring exams, respectively. Hibbard taught all courses indicated as Sec3*. The blended format was used during AY 2012-13 (cohort 1) and AY 2013-14 (cohort 2). Class (I – J) S10 – S11 S10 – S13 S10 – S14 S11 – S13 S11 – S14 S13 – S14 Mean Difference (I-J) 0.348 -0.474 -0.408 -0.822 -0.756 0.067 Std. Error 0.141 0.170 0.158 0.167 0.154 0.181 Significance (p) 0.071 0.031* 0.052 0.000* 0.000* 0.983 ANOVA: Average ACS Final Exam Raw Scores – 4 Academic Years ANOVA statistical analysis was performed on the ACS standardized final exam scores for those General Chemistry II courses taught by Hibbard for the past four years. Courses taught using the blended method during Spring 2013 (cohort 1) and Spring 2014 (cohort 2) were compared to those courses taught using more traditional methods (Spring 2010 and Spring 2011). The analysis showed that there were significant differences in test scores between those courses taught by Hibbard using traditional instructional methods as compared to the blended approach (p < 0.05; 95% confidence interval). Student Perception of Resources: General Chemistry In order to measure students perceptions regarding the blended course strategies used in the courses, a 50-question survey was developed and administered to First Years (FY), Sophomore (So) and Juniors (Jr) who had enrolled in the majors sections. Survey results showed that students believed online narrated lectures (avg=4.5) and POGIL strategies (avg=4.0) met their learning needs. While the majority of students deemed the gated testing system to be challenging, most agreed that the system prepared them for the final exam (avg=3.8). An essential aspect of the blended course is to make students responsible for their own learning and for them to relate the level of preparation to success in the course. This is evidenced by their response to the learning motivation question regarding learning responsibility and perceived success (avg=4.2). Survey questions were categorized based on the topics given in the table below. Five questions were selected for each category and analyzed for each classification of respondent. Likert Scale: 1 = Strongly Disagree; 2 = Disagree; 3 = Neutral; 4 = Agree; 5 = Strongly Agree (standard deviation). Prior Knowledge Assessment Students were assessed to determine their knowledge of fundamental Organic Chemistry concepts at the beginning of the course. The assessment contained 25 questions spanning 3 categories given below. Students assessed were from courses using blended strategies and those using traditional strategies. Cohort 1 (Blended 2013) and cohort 2 (Blended 2014). The score represents the average number of correct responses per number of questions in each category (standard deviation). Concept Category Score Blended 2013 Traditional 2013 Blended 2014 Traditional 2014 Drawing/Interpreting Organic Structures 0.37 (0.02) 0.30 (0.02) 0.45 (0.19) 0.42 (0.02) Naming Organic Structures 0.34 (0.01) 0.34 (0.01) 0.29 (0.11) 0.45 (0.47) Structure-Property Relationship of Organic Molecules 0.31 (0.05) 0.32 (0.06) 0.41 (0.18) 0.35 (0.12) Concept Category Score Blended 2013 Traditional 2013 Blended 2014 Traditional 2014 Drawing/Interpreting Organic Structures 0.27 (0.23) 0.22 (0.29) 0.51 (0.24) 0.45 (0.22) Naming Organic Structures 0.55 (0.19) 0.46 (0.44) 0.79 (0.11) 0.58 (0.29) Structure-Property Relationship of Organic Molecules 0.29 (0.15) 0.21 (0.23) 0.50 (0.16) 0.48 (0.21) Predicting Reaction Conditions and Outcomes 0.30 (0.22) 0.24 (0.27) 0.53 (0.23) 0.49 (0.20) Student Perception of Resources: Organic Chemistry The data represent the resources student utilized the most to master concepts associated with each exam (n = 26). There was heavy reliance on in-class practice and professor's notes for all exams. Further quantitative analysis is needed to correlated student performance to their use and perception of learning resources. 0 10 20 30 40 50 ChemDrills Chemistry Learning Center In Class Discussion Online Videos Professor's Notes Text Book Percent of Students Reporting Exam 4 Exam 3 Exam 2 Exam 1 Type of Motivation Pre Cohort 1 N = 27 Post Cohort 1 N = 21 Pre Cohort 2 N = 36 Post Cohort 2 N = 24 Intrinsic Motivation 3.34 (0.72) 3.31(0.79) 3.30 (0.79) 3.27 (0.87) Self-Efficacy 3.08 (0.84) 3.03 (1.01) 3.14 (0.86) 3.03 (0.95) Self-Determination 3.16 (0.75) 3.29 (0.70) 3.09 (0.78) 3.38 (0.73) Grade Motivation 3.69 (0.58) 3.50 (0.82) 3.66 (0.66) 3.47 (0.85) Career Motivation 3.75 (0.58) 3.70 (0.61) 3.66 (0.56) 3.62 (0.59) Students' Self-reported Motivation for Science Survey adapted from Glynn, S. Science Motivation Questionnaire II. The data represents the self-assessed frequency at which students demonstrated various types of motivation (given below). The pre and post results suggest that students sustained similar levels of motivation throughout the course. However, a modest improvement was observed for self-determination. Scale: 0 = Never, 1 = Rarely, 2 = Sometimes, 3 = Often, 4 = Always. Cohort 1 = Blended 2013, cohort 2 = Blended 2014 (standard deviation). 1931 CATEGORY RESPONSE AVG FY N=15 SO N=25 JR N=8 CONTENT DELIVERY 4.34 (0.17) 4.34 (0.20) 4.30 (0.30) CLASSROOM SESSIONS 4.00 (0.43) 3.76 (0.45) 4.05 (0.66) ASSESSMENTS 3.93 (0.07) 3.96 (0.16) 3.87 (0.53) LEARNING MOTIVIATION/ PRIOR EXPERIENCE 3.80 (0.38) 3.63 (0.27) 3.73 (0.81) Lessons Students do not prefer using their own device due to ease of distraction, preference for pen & paper, and limited personal data plans. However... If required to use their own device, students would prefer cellphones instead of laptops or tablets due to portability. Students believe that technology enhanced their learning experience. A cultural shift is needed for students to become acclimated to the required out-of-class activities and to overcome the stigma of "teaching one's self." However... The effort exerted by students in the flipped course allows the student to demonstrate more responsibility and self-determination in their success. There appears to be an enhanced student performance in the flipped courses in comparison to those in the traditional courses. There can be a learning curve when identifying appropriate technology and the effective use of technology in courses. A significant amount of time is required to de


Under study is a method devised to reduce sidelobes of thinned random antenna arrays over specified angular sectors. The thinned array is assumed random in the sense that the nominal location of the elements is known, but their actual position may vary randomly. It is shown that by imposing adequately dense pattern nulls, it is possible to reduce the sidelobes effectively in the region of the nulls. The problem is formulated as a set of points in the radiation pattern, which are constrained to specified values. The unknowns are the excitations, or weights, applied to the array elements. In the general case, the linear system of equations is consistent and has an infinite number of solutions. The solution selected optimizes the pattern in a minimum variance sense. Quantitative relations are derived for the pattern change and the gain cost associated with the imposed pattern nulls. Several examples are included to illustrate the results.


Objective: To purify the trypsin inhibitor protein from the seeds of Momordica dioica and characterize the protein for its stability and effect on trypsin activity. Methods: The total protein was extracted from the seeds of M. dioica, and the purification of the protein was performed by ion exchange chromatography and ultrafiltration technique. The antitrypsin activity assay of the purified inhibitor protein was carried out using N-benzoylDL-arginine-p-nitroanilide (BAPNA) as the chromogenic substrate at various pH and temperature ranges to determine the stability of the protein. The inhibitory effect of purified protein on trypsin activity was characterized by enzyme kinetic study. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis analysis was performed under the non-reducing condition to determine the presence of inhibitor protein in various fractions of elutes and its molecular mass. Results: The purified protein from M. dioica seeds showed almost 96.17±0.034% trypsin activity inhibition and 0.96±0.00 U trypsin inhibitory activity (TIA) at 30°C and pH 8. This trypsin inhibitory protein from M. dioica (MdTi) was found to be stable over a temperature range of 30-100°C and the pH range of 3-10 retaining the antitrypsin activity. The molecular mass of MdTi was found to be 12 kDa. From the enzyme kinetics, it was found that Km value remains unaffected with decrease in the Vmax of trypsin in presence of inhibitor. Conclusion: M. dioica seeds were found to posses serine protease inhibitor protein. The protein was purified and characterized as thermostable as well as pH tolerant trypsin inhibitor with high TIA. It can be well explored for its use in the agriculture industry for pest management as well as the therapeutic applications. Keywords: Serine proteases, Trypsin inhibitor, Momordica dioica, Trypsin inhibitory protein from Momordica dioica, Non-competitive inhibition.


Water resource allocation involves aspects of economy, society, ecology and resources and comprises fuzzification, uncertainty and multi-objectivity. It is therefore important to decrease the error of the weight decision caused by the influence of artificial factors and mine information contained in known data as much as possible to overcome contradiction and incommensurability among multi-objectives during scheme optimization. Here, we undertook two key steps to solve the above problem. First, using evidence theory from the field of data processing and data integration,we determine the weight of each index on the basis of the ideas that the less distance between two pieces of evidence indicates that the support degree of a piece of evidence by others is higher and the evidence is more reliable. Second, in light of the lattice-order theory, through selecting the top and bottom elements as the positive and negative ideal solutions and fusing with obtained weights,we arrived at the concept-lattice. We then selected the optimal from the alternatives by calculating the value of compound distances between alternatives and weighted positive and negative ideal solutions, by means of applying the concept of weighted Kaufmann distance or close-degree. Last,we take comprehensive evaluation schemes for Tianjin, China to verify the validity and feasibility of our evaluation method. We conclude that like the BP neural network model or fuzzy optimum selecting model or fuzzy entropy model, we can find that this method owns preferable practicability, validity and feasibility for the comprehensive evaluation for water resource allocation schemes.


Approximately 10% of primary hip replacements performed each year for osteoarthritis are in patients aged 55 or less. These patients have a longer life expectancy and a higher activity level than an elder cohort, which may translate to higher revision rates. We utilized a regional hip register (Trent and Welsh Arthroplasty Audit Group (TWAAG)) to review current surgical practice in this age group. The TWAAG group comprises 118 surgeons working in 31 different hospitals covering a population of 8 million (14.2% of the population). 1 January 2000 to 31 December 2002, we were notified of 7,678 primary THRs for osteoarthritis. 911 (11.7%) were performed on patients aged 55 or less. Age, gender, grade of lead operating surgeon, type of femoral and acetabular prosthesis implanted, fixation method, femoral head size and bearing surfaces were recorded. There were 434 males, 477 females, with an age range of 16–55. Thirty-five femoral and thirty-three acetabular components were identified. 61.7% of femoral prostheses were cemented. 67.4 % of acetabular prostheses were uncemented. 30% of THRs implanted in the group over the study period were hybrid. 50% of implants had a metal/UHMWPE bearing. Other bearing surfaces comprised ceramic/UHMWPE 28.7%, metal/ metal resurfacing 13.8% and ceramic/ceramic 7.5%. Consultants performed 84.5% of procedures. Femoral prostheses with little or no published data are used and, unless closely monitored, such practices will not be compliant with NICE recommendations. 40% of THRs performed had components implanted that were produced by different manufacturers. At the present time there does not appear to be a clear picture as to what is the 'gold' standard for young patients. Continued monitoring of these implants is essential to provide feedback and drive choice.


Such phenomena as parametric resonance, three wave resonance and similar are well known in the theory of dynamic systems, but in 1981 a new dynamical phenomenon, named stochastic resonance, was discovered. This phenomenon develops itself in the following way: if a bistable system is a subject of a simultaneous influence of harmonic noise signals, then under some circumstances, the amplitude of harmonic signal and signal to noise ratio can be increased. On the contrary to ordinary resonance, where the increasing of signal's amplitude takes place during the matching of the system's eigenfrequencies with the frequency of the external signal, stochastic resonance appears when the frequency of the external signal matches with the average frequency of the system's jumps from one stable state to another under the influence of noise. That means that during the stochastic resonance, the noise energy partly transfers into the energy of regular oscillations. It is rather interesting to apply the theory of stochastic resonance to constructing of high-power microwave oscillators. The most promising impulse high-power microwave oscillators are oscillators based on virtual cathode (so-called vircators).


From basic characteristics of product standards,the designing alloy of atmospheric corrosion resisting steel and product standards in use status currently were researched and analyzed in the article,providing useful technical reference for users.


Concussions impair cognitive function and muscle motor control; however, little is known about how this impairment affects speech production. In the present study, concussed athletes speech is recorded at the initial office visit and subsequent visits. The last recording, when the brain is determined to have recovered using present criteria, becomes the baseline. The vocabulary consists of seven h-vowel-d (hVd) words (who'd, heed, hood, hid, had, hud, and heard) produced three times each for a total of 21 productions. The study is focused on vowel characteristics and the limited coarticulatory effects of the hVd vocabulary make it ideal for the study. Duration measurements are made by experimenter analysis and the formant measurements are made using the automatic speech recognition engine ELBOW. The preliminary comparisons from the subjects completing the protocol show formant drift for three or more of the seven vowels, and duration is affected for each talker and each vowel. These results were anticipat...


The Lunar Gateway is expected to be positioned on-orbit around the Moon or in a Halo orbit at the L2 Lagrange point. The proposed Lunar Gateway is a game-changer for enabling new science utilizing CubeSats and presents a refreshing new opportunity for utilization of these small spacecraft as explorers. We propose to develop a Lunar CubeSat Lander that will be deployed from the Lunar Gateway Logistics Module (presumed to be at L2) to perform science and exploration of the lunar surface. The CubeSat lander will land near Mare Tranquilitatis to determine the extent of the void and identify the presence of volatile resources including water in its regolith. The CubeSat lander is a 27U with stowed dimensions of 34 cm×35 cm×36 cm and mass of 54 kg. It will be deployed from the Lunar Gateway and perform a lunar orbit insertion by using its onboard High-Performance Green Propulsion (HPGP) system followed by descent maneuver to get into a 25 km altitude from the lunar surface. From there, the lander will get into a powered descent maneuver over Mare Tranquilitatis taking 4-6 minutes. Onboard visual navigation will be used to land on the Mare Tranquilitatis Region by rapidly firing the descent thrusters. The lander is equipped with a Volatile Analysis by Pyrolysis of Regolith (VAPoR) instrument to perform pyrolysis and mass spectrometry of lunar regolith. Moreover, it will carry three spherical hopping robots (SphereX) that will hop inside the pit to perform mapping and electrical impedance spectroscopy of regolith inside the pit to determine the presence to water.


Different from common thin-walled workpiece, in the process of milling of large-size thin-walled workpiece chatter in the axial direction along the spindle is also likely to happen because of the low stiffness of the workpiece in this direction. An analytical method for prediction of stability lobes of milling of large-size thin-walled workpiece is presented in this paper. In the method, not only frequency response function of the tool point but also frequency response function of the workpiece is considered.


The TRA Type I Shipping Container and TRA Type II Shipping Capsule were designed and fabricated at the Idaho National Engineering Laboratory as special form containers for the transport of non-fissile radioisotopes and fissile radioisotopes in exempt quantities. The Type I container measures 0.75 in. outside diameter and 3.000 in long. The Type II capsule is 0.495 in. outside diameter 2.000 in. long. The container and capsule were tested and evaluated to determine their compliance with Title 49 Code of Federal Regulations 173, which governs packages for special form radioactive material. This report is based upon those tests and evaluations. The results of those tests and evaluations demonstrate the container and capsule are in full compliance with the special form shipping container regulations of 49 CFR 173.


Among gram-negative microorganisms Pseudomonas aeruginosa is the most common bacteria identified in different clinical specimens of hospitalized patients. A few studies have been conducted in Saudi Arabia regarding antibiotic susceptibility pattern. The purpose of this study was to evaluate the current levels of antibiotic susceptibility and to assess the resistance pattern of antibiotics among the clinical isolates of P. aeruginosa in the King Khalid Hospital, Alkharj, Kingdom of Saudi Arabia. This study was carried out during January, 2015 to May, 2015. A total of 180 different specimens such as sputum, urine, pus swabs, wound swabs etc. were collected from different patients admitted to the hospital. Thirty (30) clinical isolates of P. aeruginosa were isolated from different specimens of the patients suspected of having respiratory tract infection, urinary tract infection, wound infections, etc. The antibiotic susceptibility profiles of all the isolates were determined using Kirby-Bauer disk diffusion method. Piperacillin-tazobactam was found to be the most active antimicrobial agent with 96.7% susceptibility followed by cefepime (83.3%), ceftazidime (83.3%), and ciprofloxacin (76.7%). All isolates were resistant to ertapenem, cefuroxime, cefoxitin and nitrofurantoin. Anti-bacterial treatment strategies should focus on P. aeruginosa, for which the prevalence rates are increasing every year. The usage of piperacillin-tazobactam, cefepime, ceftazidime and ciprofloxacin must be reserved and only be given to the patients after susceptibility test to reduce the resistance of P. aeruginosa against these agents.


Combined with practical works lifting construction of box girder of Highway Bridge is introduced and discussed from general engineering situations,installation and design of box girder,construction technology and other aspects.Author points out that this lifting construction technology can meet design specifications,which is worthy of being popularized.


During the past year, evidence has accumulated to suggest that the lethal and mysterious acquired immunodeficiency syndrome (AIDS) can be spread by infusion of blood and blood products. Initially, patients with AIDS were mostly from two groups, male homosexuals with histories of numerous sexual contacts and persons who abused intravenous (IV) drugs ( JAMA [MEDICAL NEWS] 1982;248:1423-1431). Disease transmission among these two groups could be explained by person-to-person contact and shared needles. A few cases were also described among native Haitians in both Haiti and the United States. But in late 1981 and early 1982, the Centers for Disease Control (CDC), Atlanta, began to receive reports of cases of AIDS among persons with hemophilia A. Since these persons all received multiple infusions of factor VIII concentrate, the reports raised the possibility that the putative infectious agent in AIDS could be transmitted through blood products. As of mid-January 1983, there were eight


Components of Solid Oxide Fuel Cells (SOFCs) are always exposed to high temperature and large gas pressure under operation. Subjected to the starting and stopping control, the performance of SOFC is gradually degraded. One of the degradation factors can be the thermal expansive deformation due to temperature change, but the expansive deformation under reduction environment is distinguishing for SOFC. These stress-free deformations inevitably invoke the unexpectedly large stress due to the mutual constraints of the components, which sometimes causes the mechanical deterioration. At the same time, Ni particles in the porous anode electrode of SOFC are subjected to coursing due to sintering under high temperature environment. The temporal changes of the anode microstructures cause the degradation of not only the overall mechanical properties, but also the electrical performance. In order to realize the macroscopic electro-chemo-mechanical coupling analyses of a SOFC under operation, we propose a characterization method of the time-varying overall or macroscopic electrochemical and mechanical properties of anode electrodes by applying the phase-field method that enables us to capture the time-varying geometry of anode microstructures due to Ni-sintering. With this information at hand, the homogenization method is extensively applied to evaluate the temporal change of the macroscopic electro-chemo-mechanical properties that characterize the macroscopic inelastic mechanical behaviour and the oxygen potential distribution in SOFC. For the numerical simulation of oxygen potential distributions, the time-evolution of the anode microstructure is reflected not only in the macroscopic electrical conductivities, but also the amount of triple-phase boundaries, which are the generation sites of electro-chemical reaction currents. Once the oxygen potential distributions are determined, the time-variation of the reduction-induced strains due to nonstoichiometry of oxide materials can be calculated along with the thermal strains, both of which cause the macroscopic stresses in mutually constrained components. Thus, the promise and capability of the proposed method can be demonstrated in characterizing the aging degradation of the macroscopic electro-chemo-mechanical behaviour of SOFC that is caused by the Ni-sintering in cermet microstructures during long-period control.


Salon discussion amongst four panelists and the audience on issues of textiles, dress, narrative, personal heritage, belonging.

The Salon series was inspired by and supported the exhibition 'Aware: Art, Fashion, Identit'.


Counselling psychology in Australia has developed and matured since its emergence in the 1970s. This article provides a brief historical overview and situates counselling psychology (CP) in relation to other applied areas of psychology in Australia. A review of registration, professional organisations, work and role settings and core features is provided. Australian counselling psychologists work predominantly in private practice, as well as hospitals, counselling agencies, universities, medical practices, prisons and government departments. They provide assessment, diagnosis and treatment for mental health disorders and psychological problems related to adverse life events. In addition, they provide couple, family and group therapies. Challenges facing CP in Australia are explored, including a reduction in training programmes, inequities in funding for psychological services and tensions with the definition and description of the scopes of practice.


Based on the econometrics software Eviwes5.0,the economic model ARIMA(2,1,3) was established by the Gross Output Value of tertiary industry in Jilin Province during the period of 1952-2006.And the future Gross Output Value of tertiary industry in Jilin Province is predicted and analyzed.It is hoped to provide basis for planning and decision making of tertiary industry in Jilin Province.


The influence of heating temperature on the properties of nanocomposited poly [2-methoxy 5-(2'-ethyl-hexyloxy)-1,4-phenylene vinylene (MEH-PPV) polymer and titanium dioxide (TiO2) thin films has been investigated. The heating temperature was varied from 50°C, 75°C, 100°C, 125°C and as deposited thin films as reference sample. Compared with a pristine thin film (as deposited) the MEH-PPV: TiO2 heated thin film shows an improved in current-voltage, conductivity and absorbance characteristics. The variation in heating temperature has affect to the reduction of series resistance of the thin film and therefore improves the photoconductivity from 2.134×10-6 to 6.656×10-6 S.cm-1. The absorbance also shows an improvement as upon heating, the absorption spectrum of the MEH-PPV: TiO2 nanocomposite undergoes a modification compared to as deposited thin film which remains unchanged. The absorption of the heated nanocmposited thin films shows a significant red-shifted in the wavelength region ascribed to MEH-PPV (500 nm) while the absorption due to TiO2 (340 nm) does not change. Optimization of heating temperature plays a significant role for conductivity properties of nanocomposite MEH-PPV: TiO2.


In fall 2018, members of the Teaching and Learning Team at the George Mason University Libraries proposed a focus group study to assess one of the libraries' student learning outcomes. The outcome, "Students will recognize that the library's value exceeds traditional information sources in order to transfer their knowledge to experiences beyond the classroom," proved difficult to assess, but we wanted to produce some data to attempt to measure it. We hoped a focus group study of graduating seniors might provide us with evidence for this outcome.


An optical communication/switching system with data speeds well beyond any state-of-the-art electronic board-to-board computer interconnect is proposed. This interconnect is based on the use of microprism arrays to achieve large-scale, wideband interconnections for optoelectronic systems.


Starting with the Chinese social problems,the path selection of practically improving revenue distribution policy capability of government was put forward.


The author uses literature and interviews to compare elements of the Muslim inter-clan, mixed-mode mediation and arbitration tradition of Sulha in Israel's Arab community with comparable elements of Western-style mediation and arbitration practices. The author uncovers and analyzes the similarities and differences between specific Western-style and Sulha mediation and arbitration elements, such as confidentiality, venting, and neutrality. Such insights may be helpful when considering possible synergies and points of divergence between Muslim and Western dispute-resolution practices.


Lauren Kuehne wanted to branch into a new area of research characterizing the soundscape near freshwater lakes. Ethan Perlstein's postdoctoral fellowship was about to expire, but he was keen to continue his work on the pharmacology of methamphetamine. And Kay Holekamp knew her project to use hyenas as indicators of ecosystem health was important but too applied to get funding from the National Science Foundation (NSF).


Title: A Service Evaluation of Family Intervention for Psychosis training. Objective: To investigate post-training implementation issues experienced by those trained in Family Intervention. Design: A questionnaire was sent to individuals who had completed Family Intervention for psychosis training. Setting: A large NHS Mental Health Trust. Participants: Sixteen members of multi-disciplinary staff trained in Family Intervention. Measures: A questionnaire comprising both open and closed questions that had been employed in similar previous research into implementation of FI training, adapted from that used by Fadden (1997) in a study of Family Intervention training (based on that of Kavanagh et al. 1993). Results: Limited impact of training on clinical work was demonstrated. The main difficulties experienced in implementing this approach were related to the issues of availability of appropriate clients, time to do family work and integration of the work with existing workload. Promotion and prioritising of the Family Intervention approach as well as support and supervision were reported to help overcome difficulties and implement family work. Overall, the training was thought to have had a positive impact on the work of those trained. Difficulties in attending supervision related to the time required attending and competing work demands. Suggestions provided to overcome these were related to the provision of local supervision and reduction of length of supervision. Conclusions: This study has demonstrated that there are considerable difficulties in implementing Family Intervention work into routine clinical practice and considered recommendations that can be made on the basis of these findings.


University of Colorado Anschutz Medical Campus' Data Science to Patient Value Program and 2040 Partners for Health sought to create open learning materials for engaged citizens and community leaders regarding big data and big data methods to support their collaboration in patient-centered and participatorybased community research and evaluation. 2040 is a local nonprofit organization that cultivates partnerships in Aurora, Colorado neighborhoods to tackle critical health needs. Our goal was to co-design and co-create a series of big data learning modules accessible to community laypeople, so they might better understand big data topics and be empowered more actively engage in health research and evaluation that uses big data methods.


Although the phenomenon of bullying at work has been studied for more than three decades, management and prevention aspects still require greater study and systematization. Objective: to identify and systematize intervention methods on bullying. Method: bibliographical research was conducted on this topic in databases (Medline, Psychinfo, SciELO, Lilacs), books, theses and specialized sites (from 1980 to 2010). Results and discussion: the concept of bullying at work was circum scribed making the basic elements that characterize it explicit. Interventions are organized by levels of prevention (primary, secondary and tertiary) and intervention goals: targets of bullying, witnesses, workgroups and organizations. Aspects that lead to the success of the interventions and good practices are listed. Conclusion: given the complex nature of bullying at work, isolated and one-off interventions do not work. The approach needs to be comprehensive and the monitoring of actions systematic. Each case is unique and intervention design should acknowledge the organizational context and involve all the stakeholders.


Respiratory diseases got prevalent during the current pandemic (COVID 19) The current article is a systamatic review of the literature written by the scholars on respiratory failure during the CODIV-19 Articles have been downloaded from the Scopus and WoS database for the evaluation purpose PRISMA guidelines have been used for the purpose of selection of articles Graphical and tabular representation have been used to show the output


Migraine and epilepsy are distinct entities that share many features. They are both chronic neurologic disorders with episodic manifestations and have similarities of classification, ictal progression, and symptomology, particularly in the setting of migraine with aura. At times, the distinction between migraine and seizure is challenging, as outlined in this paper. Seizures with visual manifestations may be confused with migraine aura, while altered consciousness during a migraine may be difficult to distinguish from complex partial seizure. Electroencephalography, while not routinely indicated in migraine, may be useful in distinguishing migraine from epilepsy, particularly in patients with both disorders. Differentiating migraine from epilepsy is usually accomplished on clinical grounds, but challenges exist. (Adv Stud Med. 2005;5(6E):S658-S665)


Nrimo ing Pandum (Attitude of Acceptance) This Javanese philosophy is the attitude of accepting wholeheartedly all the shortcomings of what is done, never complaining. Self-acceptance is one of the most important factors for being happy. a person who can accept himself has a realistic assessment of his potential and a positive assessment of his self-esteem. The individual experiences a severe event after a family member (father) dies. The purpose of this study is to reveal in depth the cultural picture of nrimo ing pandum (self-acceptance) of the Javanese after their family members die. The method used in this research is descriptive qualitative. The design of this research is ethnographic research that reveals aspects of a culture, namely Javanese culture. Data analysis was carried out with three streams of activities that occurred simultaneously, namely data reduction, data display, and verification. The research data were obtained from two Javanese people whose father died in the last three years. Based on data analysis, it was concluded that the process of self-acceptance consists of five stages and the factors that support self-acceptance of the Javanese are; The process of accepting self and circumstances, realistic expectations, social support, influence of success, identification with well-adjusted people, parenting style, and positive self-concept.


Progress in the development of millennia‐long tree‐ring chronologies from Australia and New Zealand is reviewed from the perspective of modelling long‐term climate variability there. Three tree species have proved successful in this regard: Huon pine (Lagarostrobos franklinii) from Tasmania, silver pine (L. colensoi) from the South Island of New Zealand, and kauri (Agathis australis) from the North Island of New Zealand. Each of these species is very long‐lived and produces abundant quantities of well‐preserved wood for extending their tree‐ring chronologies back several millennia into the past. The growth patterns on these chronologies strongly correlate with both local and regional warm‐season temperature changes over significant areas of the Southern Hemisphere (especially Huon and silver pine) and to ENSO variability emanating from the equatorial Pacific region (especially kauri). In addition, there is evidence for significant, band‐limited, multi‐decadal and centennial timescale variability in the warm‐season temperature reconstruction based on Huon pine tree rings that may be related to slowly varying changes in ocean circulation dynamics in the southern Indian Ocean. This suggests the possibility of long‐term climate predictability there. Copyright © 2006 John Wiley & Sons, Ltd.


Cancer cells express high levels of CK2, and its inhibition leads to apoptosis. CK2 has therefore emerged as a new drug target for cancer therapy. A biligand inhibitor ARC‐772 was constructed by conjugating 4‐(2‐amino‐1,3‐thiazol‐5‐yl)benzoic acid and a carboxylate‐rich peptoid. ARC‐772 was found to bind CK2 with a Kd value of 0.3 nm and showed remarkable CK2 inhibitory selectivity in a panel of 140 protein kinases (Gini coefficient: 0.75 at c=100 nm). ARC‐775, the acetoxymethyl ester prodrug of ARC‐772, was efficiently taken up by cells. Once internalized, the inhibitor is activated by cellular esterase activity. In HeLa cancer cells ARC‐775 was found to activate caspase‐3 (an apoptosis marker) at sub‐micromolar concentrations (EC50=0.3 μm), a 20‐fold lower extracellular concentration than CX‐4945, the only CK2 inhibitor under clinical trials. At micromolar concentrations, ARC‐775 was also found to inhibit ADP‐induced aggregation of human platelets. The overall results of this study demonstrate that oligo‐anionic biligand inhibitors have good potential for drug development.


BACKGROUND
Medullary thyroid carcinoma (MTC) is a calcitonin-producing tumor of the thyroid arising from the parafollicular C-cells. MTC is poorly responsive to chemotherapy and radiotherapy, hence the only effective therapy is surgery. Based on this fact, alternative strategies have been sought.

MATERIALS AND METHODS
The effects of Cautleya gracilis (Smith) Dandy were investigated for the first time in three human MTC cell lines and in MTC-transplanted mice. Proliferation and viability were quantified by cell counting, WST-1 tests, and ATP luminescent cell viability assays. Apoptosis was studied by DAPI staining, flow cytometry and luminescent assays for caspases 3/7, 8 and 9.

RESULTS
A dose-dependent reduction of proliferation and an induction of apoptosis were found in all MTC cell lines, while normal fibroblasts were not impaired. Similar tumor inhibition was seen in heterotransplanted mice.

CONCLUSION
Our in vitro and in vivo findings suggest a new potential clinical effect of Cautleya.


In OSNs, data sifting can likewise be utilized for a not at all like, more mindful, standard. This is fitting to the announcement that in OSNs there is the room of redistribution or notice different posts on exacting open/private ranges, brought when all is said in done dividers. Data separating can thus be utilized to give clients the office to over and over control the messages composed all alone dividers, by sifting through undesirable messages. We consider this is a key OSN administration that has not been available as such. We propose a plan consent to OSN clients to have a straight control on the messages position on their dividers. This is accomplish through a supple standard based framework, that permits clients to alter the separating unequivocal variable to be down to earth to their dividers, and a Machine Learning-based delicate classifier naturally marking messages in hold up of substance based sifting.


Fleets have the ability to affect an adversary's use of the seas for transportation. Nations have in numerous occasions exercised this power in order to ravage their opponent's trade in times of co ...


The aim of this study was to report on the use of laparoscopic implantation of leads on the branches of the sacral plexus for neuromodulation in the treatment of chronic pelvic pain (CPP) in a multidisciplinary setting with the help of electrophysiological neuromonitoring.