Part 1 evaluates Hamby's (2016) Partner Victimization Scale (PVS) and concludes that it fails to identify cases of female PV and lacks validity. Part 2 evaluates Hamby's results as if they were correct and shows women perpetrated 2/3 as much partner violence (PV) as men and that it is frequent and a serious problem needing immediate attention. Part 3 describes a mode of conceptualization and data analysis called Dyadic Concordance Types (DCTs), which measures PV at the couple level rather than the individual perpetrator level, by classifying couples as Male-Only, Female-Only, and Both assaulted. Reviews of more than 50 studies found about half of couples are in the Both assaulted category, about a quarter Male-Only, as well as Female-Only. This applies to treatment-involved cases, to data provided by women and men, moderate and severe forms of physical violence, and regardless of the instrument used to measure physical assault. DCTs provide a more realistic and comprehensive assessment of PV because they take into account both gendered and dyadic interaction aspects of PV and both victimization and perpetration. Identifying the DCTs of cases in research or interventions is a practical step to enhance research and increase the effectiveness of services by directing attention to analyzing and treating PV as a couple problem, while also identifying sole-perpetrators. It is likely to be especially helpful in reducing violence against women. ©2016 American Psychological Association Language: en


This paper shows that the pseudopotentials of Ziman and Johnson, and Slater's augmented plane-wave potential, are members of a much larger class of pseudopotentials, and proceeds to provide criteria for choosing the pseudopotential most suitable in a given situation. In particular, once the phase shifts have been calculated for the real potential, the radius R in these pseudopotentials is a disposable parameter. A set of rules is proposed for the best choice of R, a matter which is especially important at energies above 1-2 ryd such as are used in low-energy electron diffraction (LEED). One member of this enlarged class of pseudopotentials combines the good convergence properties of the Slater form with the advantage of an angular momentum summation extending over only those values for which the phase shift is non-zero. The convergence, behaviour and misbehaviour, anticipated on theoretical grounds, are demonstrated by numerical calculations.


In any society,the foundation of order is equity which is not only one of the basic goal of public policy,but also the essential requirement of a harmonious society.At present,the equity extensively contains fair opportunity and equal income to a certain degree.In order to guarantee the realization of equal objective,we should deepen the system reform,advocate the pluralistic view of value,extend the range of democracy and establish the system of social policy.


Acute respiratory distress syndrome (ARDS) is the main complication of COVID-19, requiring admission to Intensive Care Unit (ICU). Despite extensive immune profiling of COVID-19 patients, to what extent COVID-19-associated ARDS specifically differs from other causes of ARDS remains unknown. To address this crucial question, we built 3 cohorts of patients categorized in COVID-19neg ARDSpos, COVID-19pos ARDSpos, and COVID-19pos ARDSneg, and compared their immune landscape analyzed by high-dimensional mass cytometry on peripheral blood followed by artificial intelligence analysis. A cell signature associating S100A9/calprotectin-producing CD169pos monocytes, plasmablasts, and Th1 cells was specifically found in COVID-19pos ARDSpos, unlike COVID-19neg ARDSpos patients. Moreover, this signature was essentially shared with COVID-19pos ARDSneg patients, suggesting that severe COVID-19 patients, whatever they experienced or not ARDS, display similar immune profiles. We also showed an increase in CD14pos HLA-DRlow and CD14low CD16pos monocytes correlated to the occurrence of adverse events during ICU stay. Our study demonstrates that COVID-19-associated ARDS display a specific immune profile, and might benefit from personalized therapy in addition to standard ARDS management.

Funding: This work was supported by the University hospital of Rennes, CFTR² (COVID-19 Fast Track Recherche Rennes) grant (to F.R.)and by the Fondation pour la Recherche Medicale (FRM) and the Agence Nationale de la Recherche (ANR), Flash Covid-19 joint grant (HARMONICOV to M.Cog.)

Conflict of Interest: J.Fer., F.R., S.L.G., J.D., M.Le., M.G., N.B., C.V., M.La., I.B., M.Cor., S.L., J.Feu., M. Cog. declare no competing interest. M.R., S.C., V.K.T., J.M.T., and K.T. are the inventors of a patent EP 20305642.9 "A method for early detection of propensity to severe clinical manifestations Methods" submitted June 11th 2020 under University hospital of Rennes and Scailyte AG names.

Ethical Approval: The study design was approved by our ethic committee (CHU Rennes, n°35RC20_9795_HARMONICOV, ClinicalTrials.gov Identifier: NCT04373200) and informed consent was obtained from patients in accordance with the Declaration of Helsinki.


Increased sympathetic neural activity has been implicated in the pathogenesis and maintenance of elevated arterial pressure in several forms of hypertension. Although increased adrenergic participation may alter cardiovascular performance by modifying both vascular smooth and cardiac muscle function, the effect upon the latter has received little attention. Fujiwara, Kuchii, and Shibata have recently reported that atria isolated from spontaneously hypertensive rats (SHR) exhibited lesser increments of cardiac responses from isoproterenol stimulation than normotensive rat atria (NR) (1). In our previous studies, the intact SHR myocardium failed to demonstrate the increases in heart rate and cardiac output which were observed in sex- and age-matched NR during infusions of small doses of exogenously administered norepinephrine (5). These differences of cardiac responses to norepinephrine could indicate possible quantitative or qualitative alterations in the cardiac administered sympathetic neurotransmitter, intrinsic changes in the myocardial contractile machinery, or possible differences in tonic autonomic influences on myocardial function. The present study was undertaken to examine further the responses of intact NR and SHR myocardia to betaadrenergic stimulation with the specific agonist isoproterenol. Methods. Studies were performed on the 21st and 22nd filial generation of spontaneously hypertensive rats (3) and on normotensive Wistar rats (West Jersey Biological Supply) ranging from 22 to 27 weeks of age. Commercially obtained normotensive Wistar rats (from the original Wistar strain) were used since Wistar-Kyoto (WKY) rats were not available at the time this study was initiated. In previous studies we have compared the hemodynamic and myocardial functions of these two groups of rats over a wide range (6) and following acute elevation of arterial pressure (5). It was therefore necessary to follow up the mechanisms for these observed differences, and present studies


Anaerobic digestion of organic wastes produces solid residues known as digestates, which have potential as a fertilizer and soil amendment. The majority of research on digestate focuses on their fertilizer value. However, there is a lack of information about additional effects they may have on plant growth, both positive and negative. Understanding the effects of digestate on plant growth is essential to optimizing their use in agriculture and helping close the loop of material and energy balances. This greenhouse study evaluated the effects of two different digestates, a food waste digestate (FWD) and a lignocellulosic biomass digestate (LBD); a liquid fertilizer; and various combinations of fertilizer and digestates on plant growth, nutrient uptake and nutrient use efficiency (NUE) of Brassica juncea (kai choy) plants. It also evaluated potential negative attributes of the digestates, including salinity and possible biohazards. Combinations of LBD and fertilizer performed as well or slightly better than the fertilizer control for most parameters, including aboveground biomass and root length. These same combinations had significantly higher nitrogen use efficiency than the fertilizer control. Inhibitory effects were observed in 100% LBD treatments, likely due to the high electrical conductivity of the media from digestate application. Based on this research, LBD could partially replace mineral fertilizers for kai choy at up to 50% of the target nitrogen rate and may lead to increased plant growth beyond mineral fertilizers. FWD could replace up to 100% of the target nitrogen application, without causing significant negative effects on plant growth. Increasing the use of digestates in agriculture will provide additional incentives for the anaerobic digestion process, as it produces two valuable products: biogas for energy and digestate for fertilizer.


Purpose
Regardless of the materials used, additive manufacturing (AM) is one of the most popular emerging fabrication processes used for creating complex and intricate structural components. This study aims to investigate the effects of process parameters – namely, nozzle diameter, layer thickness and infill density on microstructure as well as the mechanical properties of 17–4 PH stainless steel specimens fabricated via material extrusion AM.

Design/methodology/approach
The experimental approach investigates the effects of printing parameters, including nozzle diameter, layer thickness and infill density, on surface roughness, physical and mechanical properties of the printed specimens. The tests were triplicated to ensure reproducibility of the experimental results.

Findings
The highest ultimate tensile strength, 795.26 MPa, was obtained on specimen that was fabricated with a 0.4 mm nozzle diameter, 0.14 mm layer thickness and 30% infill density. Furthermore, a 0.4 mm nozzle diameter also provided slightly better ductility. This came at the expense of surface finishing, as a 0.25 mm nozzle diameter exhibited better surface finishing over a 0.4 mm nozzle diameter. Infill density was shown to slightly influence the tensile properties, whereas layer thickness showed a significant effect on surface roughness. By contrast, hardness and ductility were independent of nozzle diameter, layer thickness and infill density.

Originality/value
This paper presents a comprehensive analysis relating to various input printing parameters on microstructural, physical and mechanical properties of additively manufactured 17–4 PH stainless steel to improve the printability and processability via AM.


Crosstalk phenomena and pulse propagation in coupled microstrip lines on insulating and semiconducting substrates are analysed. Propagation characteristics of these lines are obtained by Spectral Domain Analysis in order to avoid any error involved by the use of analytical model and T.E.M. approximation. Time domain results are calculated by a conventional fast Fourier transform. Effects of semiconducting layer, substrate thickness, lines spacing and length, loading impedances, on crosstalk and transfer are investigated.


ABSTRACT Generalized Abel type integral equations with Gauss, Kummer's and Humbert's confluent hypergeometric functions in the kernel and generalized Abel type integral equations with localized fractional integrals are considered. The left-hand sides of these equations are inversed by using generalized fractional derivatives. Explicit solutions of the equations in the class of locally summable functions are obtained. They are represented in terms of hypergeometric functions. Asymptotic power exponential type expansions of the generalized and localized fractional integrals are obtained. The base solutions of the generalized Abel type integral equation are given in the form of asymptotic series.


A newborn has a small, pedunculated mass attached by a fine stalk to the ulnar aspect of his fifth digit.


Acinetobacter baumannii)
ABSTRACT: Background: Biofilms are composed of more than one species or often called polymicrobial biofilms, so research is needed on the formation of polymicrobial biofilms, especially between fungi and bacteria. This study aimed to analyze the total biomass and metabolic activity of biofilms formed from the interaction of fungi (Candida tropicalis) with bacteria (Staphylococcus aureus, MRSA, Pseudomonas aeruginosa, and Acinetobacter baumannii); Methods: Bacterial and fungal cultures were suspended in Tryptic Soy Broth (TSB) medium, then biofilm was cultivated in two 96-well microplates, then the microplates were incubated at 37 degrees Celsius for 48 hours. Detection of the biofilm will be carried out using the Crystal Violet assay and reduction of the tetrazolium salt (3-(4,5-dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide), or MTT assay to obtain the Optical Density (OD) value by using ELISA reader; Results: The results of this study obtained significant data from both parameters, the highest average value was found in the C. tropicalis treatment group (2,412 ± 0.825 on the biomass test results; 1,525 ± 0.473 on the metabolic activity test results), while the lowest was seen in the S. aureus treatment group (0.512 ± 0.224 in the biomass test results; 0.978 ± 0.349 in the metabolic activity test results); and Conclusions: In the total biomass parameter, it was obtained that the biofilm biomass could be formed strongly in each treatment, while the results of the metabolic activity showed that each treatment was able to carry out cell proliferation.


Impedance-source networks cover the entire spectrum of electric power conversion applications (dc-dc, dc-ac, ac-dc, ac-ac) controlled and modulated by different modulation strategies to generate the desired dc or ac voltage and current at the output. A comprehensive review of various impedance-source-network-based power converters has been covered in a previous paper and main topologies were discussed from an application point of view. Now Part II provides a comprehensive review of the most popular control and modulation strategies for impedance-source network-based power converters/inverters. These methods are compared in terms of theoretical complexity and performance, when applied to the respective switching topologies. Further, this paper provides as a guide and quick reference for researchers and practicing engineers in deciding which control and modulation method to consider for an application in a given topology at a certain power level, switching frequency and demanded dynamic response.


The hierarchy problem follows from the very big energetic gap between the Planck scale and the masses of the most massive known particles. This problem is solved within the Scale-Symmetric Theory. This theory starts from the four succeeding phase transitions of the superluminal non-gravitating Higgs field composed of pieces-of-space/tachyons (due to the size of our Cosmos, there are possible four transitions only). There appear the very different scales i.e. the superluminal-quantum-entanglement scale, luminal Planck scale, electric-charges scale and cosmological scale. Due to the irreversible processes during the inflation, the electron-neutrinos and muon-neutrinos are the stable particles. The observed oscillations follow from the decays or creations of the unstable tau "neutrinos" that consist of three different stable neutrinos and from the exchanges of the free neutrinos (they interact gravitationally only) for the neutrinos in the neutrino-antineutrino pairs the Einstein spacetime consists of.


A big number of monitored features in examined obj ects often complicates a technical realization of d ecision-making and extends the time necessary for providing a decision . It is possible to decrease dimensionality of the tasks and along with not to decrease a quality of decision-making. The main sub ject of this contribution relates to some of the possible approaches. Basis of these methods stays in finding a linear transformat ion of original m-dimensional space of features int o a new n-dimensional feature space where n m ≤ . New features are arisen by suitable linear combinat ion of original features and they are descending so rted according to their variance. The contribution descr ibes experience and results obtained with the decrea sing of feature space and the classification of sets of the objects which where re presented by real pictures of the Earth surface.


ABSTRACT Axons and dendrites are long and often ramified neurites that need particularly intense plasma membrane (PM) expansion during the development of the nervous system. Neurite growth depends on non-fusogenic Sec22b–Stx1 SNARE complexes at endoplasmic reticulum (ER)–PM contacts. Here, we show that Sec22b interacts with members of the extended synaptotagmin (E-Syt) family of ER lipid transfer proteins (LTPs), and this interaction depends on the longin domain of Sec22b. Overexpression of E-Syts stabilizes Sec22b–Stx1 association, whereas silencing of E-Syts has the opposite effect. Overexpression of wild-type E-Syt2, but not mutants unable to transfer lipids or attach to the ER, increase the formation of axonal filopodia and ramification of neurites in developing neurons. This effect is inhibited by a clostridial neurotoxin cleaving Stx1, and expression of the Sec22b longin domain and a Sec22b mutant with an extended linker between the SNARE and transmembrane domains. We conclude that Sec22b–Stx1 ER–PM contact sites contribute to PM expansion by interacting with LTPs, such as E-Syts. This article has an associated First Person interview with the first author of the paper. Highlighted Article: The non-fusogenic Sec22b–Stx1 SNARE complex contributes to plasma membrane expansion by interacting with the E-Syt lipid transfer proteins at ER–PM contact sites.


Global warming can be reduced by controlling emissions in motor vehicles. Lightweight aluminum materials can lower the engine work so as to reduce fuel consumption.The effect of dwell time on mechanical properties and microstructure friction stir spot welded AA1100 with particle interlayer Zn were investigated. The result shows that the particle interlayer Zn affect to the mechanical properties. The tensile shear load friction stir spot welded AA1100 with particle interlayer Zn is higher than hart of without particle interlayer Zn. In line with tensile shear load that the hardness of friction stir spot welded Al with particle interlayer Zn got the higher hardness than of without particle interlayer Zn. The addition of particle interlayer Zn reduce the hook defect and spread in the aluminum matrix as solid solution.


Using a tractable extension of the model of Leland (1985), we study how a delta‐hedging strategy can realistically be implemented using market and limit orders in a centralized, automated market‐making desk that integrates trading and liquidity provision for both options and their underlyings. In the continuous‐time limit, the optimal limit‐order exposure can be computed explicitly by a pointwise maximization. It is determined by the relative magnitudes of adverse selection, bid–ask spreads, and volatilities. The corresponding option price—from which the option can be replicated using market and limit orders—is characterized via a nonlinear PDE. Our results highlight the benefit of tactical liquidity provision for contrarian trading strategies, even for a trading desk that is not a competitive market maker. More generally, the paper also showcases how reduced‐form models are competitive with "brute force" numerical approaches to market microstructure. Both the estimation of microstructure parameters and the simulation of the optimal trading strategy are made concrete and reconciled with real‐life high frequency data.


The goal to be achieved in this research is to describe the determination of the cost of production that is performed at a venture know in Turen. In this research, quantitative analysis by the use writers techniques. Formulas that in use among other is counting the cost of production, the number of elements production and the cost of production.
Business know Turen determine the cost of production know crude and know raw based on the estimated costs incurred in producing know. Meanwhile, according to the result of reckoning writer the cost of production know raw Rp 1.667,- / cut into strips and fried know as much as Rp 357,- / seeds. It was after conducted identification and accumulation costs of production in producing know crude and know raw.
From the research can be taken in the conclusion that the determination of the cost of production at a venture know in Turen regarded as effective as elements are taking into account the cost of production cost of raw materials, labor costs direct and overhead plant which includes indirect labor costs, and the burden of a retraction so that the calculations are will be right. Based on a sentence by way of hence writers expect business know this is able to compete in the market and efficiency in the manufacture of raw do know that the determination of the cost of production is not too high.


The book studies the composition and comparison of Aitareya and Kausitaki Brahmanas of Rigveda and their rituals. Both the Brahmanas are important, for they have preserved for us the ancient tradition of their schools. This work is a contribution to the knowledge of sacrificial cult that characterized Indian life in the Vedic age.


There have been many scholarly discussions if EU can be a global power or not. Global power normatively has to have certain conditions and properties. Being a great military power would not make a country become a global power, in contrast with what some scholars argue. A global power also has the best of the brains, is attractive to researchers, provides freedom of expression and leaves space for creativity as much as gives the tools for novelty. All these cases might be provided but access to them might be limited by the immigration policies. Even though the EU and member countries in particular have achieved great accomplishments in their migration policies for the highly skilled, they do not seem to be sufficient and farsighted. The perspective towards immigration affects the whole approach to the high skilled: promoting circular migration, difficulty in transitions to permanent statuses and lack of consideration of skill losses. It is assumed that the high-skilled migrants automatically integrate and so integration policies are not devised specifically for them. It is also believed that they would bring the know-how to their home countries as a result of return migration but many of them after four or five years, hesitate to turn back to their homes. They would rather lead transnational lives. These details are not considered in EU migration policy for the highly skilled. I suggest that the EU policies on high-skilled migration should be combined with other integration policy tools. Otherwise, EU will remain behind the traditional brain attracting countries such as Australia, Canada and the USA and will never be a full-fledged global power. I tried to answer this question indeed: are the high-skilled migration policies of the EU sufficient in their design to turn EU into a global power? The answer is "no" and I explain why in this paper.


modernization is correct. Giddens is very aware of the criticisms he is likely to attract and I found frequently that having read a passage I disagreed with I turned the page to find the author confronting my misgivings. However there are three serious queries I have of Giddens' thesis that I feel warrant more concern than he gives them. First, his treatment of time privileges trends over cycles there is no consideration of Kondratieff


A simple method is described for quickly and easily designing high-performance optical systems. It involves little iteration, if any, and requires neither a computer nor extensive hand calculations. The systematic application of this design method allows one to construct configurations where the function of every surface is clearly understood. As a result, new design configurations tend to suggest themselves to the designer. This insight, which is an integral part of the design method to be described, also makes it clear how to compound designs so as to extend the f/# and/or field of view over which high performance is obtained. Although the design method only uses well-known principles of aberration control, it combines them and systematically applies them in a particular way that has not gained the wide use it merits. Several design examples illustrate how this design method is applied. They include a telephoto lens, an inverse telephoto lens, a fisheye type lens and a catadioptric system.


Heavy metals are one of the most hazardous pollutant in the water. Thereare many methods for heavy metals remediation such as precipitation, oxidation, reverseosmosis, ion exchange and sorption by reactive materials. Zeolite is one of reactive materials have been used for water remediation. Therefero, in this the capability of zeolite from Gedangsari District, Gunung Kidul Regency, Special Province of Yogyakarta, Indonesia, will be invetigated to remidiate contaminated water by selenium (Se) and Zinc (Zn). To answer this objective, several samples of natural zeolitic tuff were taken and charaterized. Laboratory experiment was done by batch test. The results showed that natural zeolitic tuff is an effective adsorbent of Se and Zn and holds great potential material to remove heavy metals in water. The sorption isotherms of Se and Zn confirmed to type of Langmuir or Freundlich isotherms.


ABSTRACT Securing a first academic job in the United States as a young professional can be a very time consuming and stressful process. Candidates must carefully apply and then typically navigate off- and on-campus interviews. Although there is some literature dedicated to aiding in this process, some areas are not extensively discussed, such as contract negotiation. In addition, best practices for those assistant professors considering moving from one institution to another prior to tenure is limited. This article provides practical recommendations for those seeking their first or potentially second job across the kinesiology disciplines. Although the focus is on tenure track positions, most of these suggestions would be applicable to any candidate early in their career. Using personal experiences as applicants, search committee members and chairs, and upper-level administrators, in addition to the input of other faculty and leaders in the field, we provide contemporary recommendations for cover letters, interview preparation, the interview process, and negotiating contracts, as well as a discourse on the critical elements associated with securing a second job prior to tenure.


In this paper, we demonstrate that multiple tapers in optical fibers allow for quasi-distributed refractive index sensing via a high spatial resolution Brillouin Optical Frequency-Domain Analysis (BOFDA) configuration. We first characterize, theoretically and experimentally, the variation of the Brillouin frequency shift (BFS) with the diameter of the tapered fiber. Then, we characterize the dependence of the BFS from the outer refractive index in an optical fiber taper with a waist diameter of 10 µm. Finally, we show that more tapers can be realized along the same fiber, in order to provide multi-point refractive index sensing.


A new analytical model is suggested to describe the radial cracking around a ribbed reinforcement bar embedded in a quasibrittle material such as concrete. The model is based on the partly cracked solution of a thick-walled cylinder, exposed to radial internal pressure. For the partly cracked inner ring of the cylinder an exponential softening model is applied to model the hoop stresses across the fictitious crack. The main advantage of applying an exponential softening relationship instead of a linear or a power-law model, which have been applied in previous investigations, is that the asymptotic behaviour of the exponential softening turns out to be a useful analytical feature. Another difference between the present analytical model and the previous solutions is that the radial displacements in the inner ring are assumed to be equivalent with the linear-elastic displacement field. Furthermore, the solution employs the brittleness number to give a dimensionless description of the problem. Through this br...


: The recently released two monthly maximum water depth maps by Teng et al., (2023) provide opportunities for scientists to examine the relationship between hydrological and ecological processes. The depth maps provide a consistent spatial estimate of flood water depth across the Murray–Darling Basin (MDB) over the past 35 years. The product is available from CSIRO's Data Access Portal at (https://doi.org/10.25919/c5ab-h019) and through web portal (https://map.csiro.easi-eo.solutions/). The dataset including its validation against hydrodynamic models is described in Penton et al. (2023). This abstract provides guidance on how best to use the product to undertake further analysis. We recommend a four-step process to systematically account for the product's accuracy. First, researchers should confirm with local sources (using web portal) that major floods in the region of interest are visible in the product (were cloud-free during acquisition). Second, most analyses will require around 20 two-monthly images so the model errors converge to a known statistical distribution (e.g. a Laplace or Cauchy distribution). Given enough images, it is then possible to remove the product bias by increasing the flood depth by 0.34 m (the median error estimated in the benchmark set). Third, when estimating the water depths for locations with permanent water storages (especially reservoirs) use a local data-source to infill. For example, infill with depths calculated from observed levels in large reservoirs using bathymetry, which are usually available from the reservoir operator (the bathymetry may need to be digitised). Finally, we recommend calculating the sensitivity of the results and conclusions to scaled depth inputs.


Apoptosis, a cell death mechanism regulated by Bcl‐2 family members, has been proposed as one of the mechanisms leading to neuronal loss in Huntington's disease (HD). Here we examined the regulation of Bcl‐2 family proteins in three different mouse models of HD with exon 1 mutant huntingtin: the R6/1, the R6/1:BDNF+/−, and the Tet/HD94 in which the huntingtin transgene is controlled by the tetracycline‐inducible system. Our results disclosed an increase in the levels of the BH3‐only proteins Bid and BimEL in the striatum of HD mouse models that was different depending on the stage of the disease. At 16 weeks of age, Bid was similarly enhanced in the striatum of R6/1 and R6/1:BDNF+/− mice, whereas BimEL protein levels were enhanced only in R6/1:BDNF+/− mice. In contrast, at later stages of the disease, both genotypes displayed increased levels of Bid and BimEL proteins. Furthermore, Bax, Bak, Bad, Bcl‐2, and Bcl‐xL proteins were not modified in any of the points analyzed. We next explored the potential reversibility of this phenomenon by analyzing conditional Tet/HD94 mice. Constitutive expression of the transgene resulted in increased levels of Bid and BimEL proteins, and only the Bid protein returned to wild‐type levels 5 months after mutant huntingtin shutdown. In conclusion, our results show that enhanced Bid protein levels represent an early mechanism linked to the continuous expression of mutant huntingtin that, together with enhanced BimEL, may be a reporter of the progress and severity of neuronal dysfunction. © 2007 Wiley‐Liss, Inc.


Abstract Both knee osteoarthritis (KOA) and depressive symptoms are common health issues affecting the quality of life of old adults. Although it is presumed that KOA has a bidirectional relationship with the depressive symptoms, no cohort study has proven it. This is the first study to determine the strength of association for the bidirectional relationship between KOA and depressive symptoms. Data were gathered from the nationally survey of China Health and Retirement Longitudinal Study in 2011-2015. The presence of depressive symptoms was defined by the 10-item Center for Epidemiologic Studies Depression Scale score of 10 or higher. The adjusted Cox proportional hazards regression model was conducted to estimate hazards ratios (HRs). Controlled covariates include gender, age, education, marital status, residence, number of chronic diseases, and disability. The analysis of KOA predicting the depressive symptoms onset consisted of 4,377 participants free from depressive symptoms at baseline. During 4 years follow-up, diagnosed KOA participants were more likely to have depressive symptoms than their peers without KOA (HR = 1.50, 95% CI: 1.23-1.83). The parallel analysis of depressive symptoms predicting KOA onset included 6,848 participants without KOA at baseline, those with depressive symptoms had a higher relative risk of developing KOA (HR = 1.64, 95% CI: 1.41-1.92). Our results provide compelling evidence that the KOA-depressive symptoms association is bidirectional, highlighting the importance of evaluating the relationship between physical and mental health among older people. Particularly, taking this association into consideration in the risk assessment and primary prevention of KOA and depression symptoms.


In order to balance the relationship between D2D users' capacity and energy consumption in a cellular network, an energy-saving transmission mechanism based on non-orthogonal multiple-access (NOMA) enhancement is designed in this paper to increase the number of D2D multiplexing of limited cellular resources. At the same time, to reduce the energy overhead of relay, the idle D2D is used as a relay node and the simultaneous wireless information and power transfer (SWIPT) technology is used to compensate its own energy consumption in the forwarding process. In this paper, a nonlinear fractional programming problem is established to maximize the energy efficiency (EE) of D2D clusters. To overcome the non-convexity of the objective function and the coupling of parameters, we solve the approximation of the original optimization problem based on fractional programming and sequential convex approximation theory. First, the maximum energy efficiency is obtained by dichotomy; Then the sequential convex approximation method is used to solve the corresponding optimal transmitting power; Finally, genetic algorithm is used to get the optimal configuration parameters of the system; The above steps are alternately iterated until convergence to obtain the optimal solution. The simulation results show that the algorithm we proposed has faster convergence and is better than the orthogonal multiple access (OMA) technology in the improvement of energy efficiency performance.


Many high voltage components are subjected to relatively high thermal cycles. In castings, there is often a combination of metal inserts combined with insulating materials. The resulting difference of thermal expansion coefficients will lead to variable mechanical and electrical intrinsic stresses in the cast components. This calls for insulating materials which are able to resist crack propagation under all kinds of fast changing operational temperatures. Newly developed toughened epoxy casting systems for indoor and outdoor applications, and their advantages over the state of the art mineral filled systems, are presented in this paper. It is shown that these new innovative materials can successfully withstand temperature cycles between 150/spl deg/C down to -50/spl deg/C without being damaged, whereas traditional epoxy systems may already show cracking failures at 0/spl deg/C. These new materials are easily processable on conventional casting equipment. They exhibit slightly higher viscosity, but this can easily be controlled by using the rapid APG technique. Therefore it can be stated that these toughened materials may be used in all existing application fields whenever high crack resistance must be achieved under harsh operational conditions.


This contingency plan for hazardous waste release provides guidance for coordinating response efforts at Site 300, Lawrence Livermore National Laboratory (LLNL). The goal of this plan is to minimize hazards to human health and life, and protect livestock, wildlife, the environment, and property in the event of a fire, explosion, or any unplanned release of hazardous substances or mixtures to the air, water, or soil. This plan includes: an overview of LLNL Site 300's emergency response capabilities; and a description of responsibilities assigned to LLNL facility personnel and to LLNL and non-LLNL emergency response personnel.


The logic of capital has dominating role on the development of capitalism.There are two kinds of the logic of capital:one is lack foresight,the other is continuable.The former had exerted a tremendous influence on the development of capitalism in its early stage.However,with the development of capitalism,the latter has played more and more important role.Influenced by the two models,the capitalism is moving towards rational state.


The article offers news briefs on clinical medicine. Topics include a study which analyzed the level of stress experienced by pediatric intensive care unit (ICU) staff including respiratory therapists during the COVID-19 pandemic, a study on the feasibility of using mobile application (app) to provide cognitive behavioral therapy (CBT) to family members of adult ICU patients, and a study on the association between pepsin A and clinical outcomes of ICU patients.


Since many patients in methadone maintenance treatment programs have legal problems, the authors suggest that such programs employ an attorney to help them. They discuss the attorney's role in allaying patients' anxieties about the legal system, in guiding them through it, and in educating the courts about methadone maintenance programs. They also present data on the kinds of offenses addicts in their program committed in a one-year period.


ABSTRACT Since the late 1970s, the Access to Higher Education (Access to HE) Diploma (the Diploma) and its predecessor Access to HE certificates and courses have provided opportunities for adults to undertake the preparation they need to progress to higher education (HE). The Quality Assurance Agency for Higher Education (QAA) has been collecting data about these students since 1998, working with a variety of further education (FE) and HE agencies, and has published annual reports. This paper brings together this information to consider the question of whether or not this qualification has contributed to widening participation in HE. General patterns in the data are presented, acknowledging that some changes in data collection methodologies over the years place limitations on the statements that can be made. The paper suggests that nonetheless this unique set of data does indicate that Access to HE has made a contribution. However, some of the changes in patterns of the proportions of widening participation characteristics in Access to HE entrants to HE raise questions for further analysis, and changes in the context of FE and HE structures and funding may pose challenges to Access to HE students and their progression to HE.


Abstract The radiographic findings in twelve cases of persistent left superior vena cava are described. On plain chest films it may present as a widening of the aortic shadow, a paramediastinal bulge, or as a paramediastinal strip or crescent along the upper left cardiac border. Although the left arm vein has been preferred for cardiac catheterization, satisfactory angiocardiographic results were obtained by catheterization of either the saphenous vein or right arm vein in 8 cases. The radiographic appearance of persistent anomalous left vertical pulmonary vein is presented as an aid in differential diagnosis.


The ability to integrate, adapt and strive in the community has become a focal point in research with individuals who have an intellectual disability. However, research regarding teaching social skills to adults who are preparing to transition into the community is limited. The purpose of this study is to utilize peer tutoring with adults who have a mild intellectual disability. Furthermore, a video feedback component will be added in an attempt to enhance the effects of peer tutoring. This overall aim is to increase social skills in adults who are currently living in an institutionalized setting and who may be able to transition into a community residential setting in the future. The results of this study provide preliminary support for a peer tutoring intervention and video feedback in order to enhance social skills with adults who have a mild intellectual disability. Peer tutoring is an intervention that is generally used with children and youth in school settings when increasing social skills. The data suggest that peer tutoring is an effective strategy for increasing social skills in adults with mild disabilities. The data also demonstrated that video feedback does enhance the effects of peer tutoring despite the high levels of appropriate behavior that peer tutoring facilitated.


Natural materials used to close wounds include flax, hair, grass, cotton, silk, pig bristles, and animal gut. Agaves were the source of many essential items due to its high tensile strength. Agave fibers were investigated for it's potential use to close the topical incisions in rat. Sutures were developed i.e. Agave suture from the isolated fibers of Agave americana L. var. americana (Agavaceae) plant and were coated with the ethanolic extract of Aloe vera. These were evaluated for Physical properties which proved good tensile strength, handling properties, low tissue drag, acceptable knot security, low microbial infiltration, toxicity and faster incision wound healing in rats compared to commonly utilized surgical sutures from market. Wound healing was evaluated by observing pus formation, inflammation, incision wound closure period, tensile strength measurement and histo-pathological evaluation of healed wound tissue. All the mentioned tensile strength tests were performed by a tensile strength testing apparatus, especially designed and constructed for our purpose. According to findings Agave suture shown acceptable results and hence for can be considered for further research and utilization.


Progressive collapse occurs when the local failure of the primary structure leads to an eventual collapse of the structure as the adjoining load-bearing elements fail to transfer the load of the lost column. This analysis checks whether the load transfer from adjoining members upon loss of columns. A 10-storey RC structure of square and circular plan geometry were considered in this study. The buildings were modelled and designed for gravity, wind and earthquake loads as per the guidelines of respective Indian Standards. Further those models were examined for progressive collapse considering different critical column removal scenarios. The DCR results were calculated for the adjacent beams and adjacent columns to check whether the structure elements reach an alternate equilibrium of the load path or not. Out of both the geometry, the circular plan building was showing better performance then square plan building and it is about 10% to 20% better based upon all the analysis and for different loading conditions.


In this article, two different anionic ligands, 3,4-oxybis(benzoate) (bopH2) and sulfate, have been employed as co-ligands to perform a comparison on the structures of coordination polymers based on the Zn(II)–rigid 1,4-bis(imidazol-1-yl)benzene (bib) net. Two new coordination polymers, {Zn(bib)(bop)}∞ (1) and {Zn(bib)(SO4)}∞ (2), were synthesized from hydrothermal reactions and characterized by elemental analyses, IR and single-crystal X-ray diffraction. Complex 1 contains two unique 2-D layers, which are further interpenetrated to form a two-fold 2-D → 2-D framework. However, 2 consists of a 3-D structure with pcu topology constructed by sulfates as pillars. The structural difference of 1 and 2 indicates that size of the ancillary ligands play important roles in formation of such coordination architectures. Thermal and fluorescence properties of 1 and 2 are also investigated in the solid state.


spin-echo-sequences before and after i. V.-application of Cd-DTPA. Superficially growing lesions of stage T, could not be delineated from isointense mucosa. The preoperative staging of T,-T, lesions can be markedly improved by iising T, - and T,- weiglited sequences in combination with Cd-DTPA. MR imaging with Gd-DTPA is recommended as the primary diagnostic tool for diagnosing lesions in the regioii of tlie oropharynx.


In order to test the dynamic characteristics of SiC MOSFETs more accurately, it is necessary to redesign the dynamic test platform for SiC MOSFETs. The parasitic inductance of the power circuit of the dynamic test platform is analyzed, and different stacked bus structures are designed according to the test requirements of different devices. In practical use, considering better matching the size of the dynamic test platform and making reasonable use of the internal space of the cabinet, the laminated bus bar is designed as a bent structure, and the two design schemes are simulated and compared. Finally, the splicing type laminated busbar structure is selected.


On the face of it, affairs of the human heart are far removed from the world of mathematics. On the one hand, the mathematicians amongst us might see the lack of precision in the former as reason enough to dismiss it from the proper domain of mathematical analysis. On the other hand, the romantics amongst us might see the cold, calculating nature of mathematics as an inappropriate tool for the study of love. The Mathematics of Love goes some way toward dispelling both these lines of thought and shows how mathematics can, indeed, shed light on love, sex, and romance. The book is not written for a mathematical audience; it's written for a lay audience and presupposes very little by way of mathematical training. The few technical details presented are introduced with such care and patience that even those averse to mathematics should not be put off—such people may even warm to mathematics once some of what it can do is better appreciated. Indeed, this is a large part of Hannah Fry's mission in this book: "my great hope is that a little bit of insight into the mathematics of love might just inspire you to have a little bit more love for mathematics" (p. xii). The fact that the book is not written for a mathematical audience does not mean, however, that there is no interest here for mathematicians. The book is engaging, humorous, and full of nice examples of applications of various branches of mathematics to human relationships. It would make a good supplementary text for teaching purposes at both high school and undergraduate level. I would imagine that one could build an interesting, if somewhat idiosyncratic, undergraduate course around this book, if the


Previous research has examined biomedical metaphors in discourses on military intervention, counter-insurgency and counter-terrorism. Starting from the observation that such metaphors also occur in the contemporary conflict prevention discourse, this article inquires into their intellectual origins and implications for the understanding of war and prevention. Drawing on archival analysis, it finds that they manifest in two ways in prevention discourse. In the cataclysmic notion, war is likened to an epidemic or plague. This metaphor was popularised by Christian pacifists in the 19th century and carried forth into 20th-century prevention documents. The more recent risk factor notion is couched in terms of enabling conditions for threats to the body politic. By engaging imagery on immunity and public health, it draws parallels between social and political organisation and functions of the body. The article argues that while both notions of biomedical metaphors of war in conflict prevention discourse are firmly rooted in modernist thinking, this intellectual legacy manifests differently. The cataclysmic notion associates war and disease with barbarism and thus paints prevention as a civilisational objective. The risk factor notion, on the contrary, represents war as a technico-scientific problem and thus shifts the focus towards governing and controlling war through knowledge and technology. Furthermore, both notions converge in the idea of a body politic that is to be protected and in the implicit assumption of world order in which war-as-disease is a temporary deviation from the 'healthy norm', while peace-as-health is the desired and default state of affairs.


Nowadays, more and more people have their own accounts in different social networks, and they might use the different email addresses or phone numbers in different networks, so how to identify the same person among different social networks become a vital problem, called network alignment. Users with different accounts are called anchor users, researches showed that using some known anchor users to predict the potential anchor links for the full network is an effective way. To predict more accurate anchor links, the paper proposes a new prediction framework ISS, based on a reality of partially aligned social networks, it applies supervised learning based on social feature extraction and strict stable matching, which improve the accuracy of the prediction result, what is more, we apply an iterative framework to refine known information and maximize the prediction results. Experiments have conducted in two realworld heterogeneous social networks, Foursquare and Twitter, and it demonstrates that ISS can predict anchor links among heterogeneous social networks very well and outperform other similar prediction methods.


The first experiments are reported on oestrus synchronization in cattle in the Republic of Mali. The animals recieved Bovisynchron twice a day orally over a period of 15 days. The synchronization effect was marked; insemination was performed on the 5th and 6th day p.s. The intensity of the oestrus and especially the results of pregnancy are in close relationship to the breeding conditions and the general status of the animals. The oestrus synchronization is considered a favourable biotechnical method for regulating the reproduction provided that the animals are kept stationary or temporarily stationary.


Soda lakes have always attracted the scientific community with the microorganism existing in the Alkaline habitat specifically the cyanobacteria. In the present study based on morphological difference 7 species belonging to 4 genera and 2 orders were observed which were isolated from alkaline saline Lake Lonar situated in the Buldhana District of Maharashtra, India. All the cyanobacteria reported were nonheterocystous. A relatively lower diversity of the cyanobacterial population was observed in alkaline lake. A significant correlations obtained between 'total chlorophyll' and 'chlorophyll a' and cyanobacterial density, but some non significant correlations were also observed with some of different physicochemical parameters. Regression analysis for significant correlations between environmental parameters of habitats and 'chlorophyll a' as well as bacterial count were observed and analyzed. Significant correlation (p<0.05) was obtained between chlorophyll a content, cyanobacterial density, and the physicochemical parameters in the year 2009 as compared to year 2007 and 2008. The fluctuation of the population density during the 3 years of investigation showed a decrease from 2007-2009. The highest population density was noticed in all the three years after the month of May, i.e. the monsoon and post monsoon period and decrease in the density in the month of October.


The different mechanisms, rotation, inversion, or intermediate mechanism, by which occur the topomerization of imine systems R2 CNX have been studied by applying ab initio, B3LYP, and MP2 methods. The effect of a wide variety of substituents R and X on the isomerization pathway have been examined by computing fully optimized structures of the ground and transition states (136 isomers belonging to different imine families were studied and more than 300 transition structures were determined at various levels of theory). Energy barriers have been also obtained and it was found that the groups R and X have a strong influence on the type of mechanism involved and the activation energies. Thus, and depending on the type of substituents, transition state structures related to the following kinds of processes were found: pure inversion, intermediate mechanisms, rotation, and enhanced rotation (hyper‐rotation). In turn, the corresponding activation energies range between very low (<10 kcal/mol) and extremely high (> 70 kcal/mol) values. A simple index that allows us to quantify the percentage of inversion or rotation mechanism is proposed. © 2009 Wiley Periodicals, Inc. J Comput Chem, 2010


On 15 October 1914, a quite particular brigade was sent to the front line to cover the retreat of the Belgian army. Commanded by a naval officer, Admiral Ronarc'h, it consisted of two regiments of naval conscripts who had, for the most part, no experience of combat on land. They were quickly sent into action in the swamps of Yser and their losses were very high. The press at once seized upon the action, and with the encouragement of the Ministry of the Navy it became known as the "Battle of Dixmude.". Journalists and propagandists, while overstepping certain points, built the action of these sailors into a legend. Once again truth fell casualty to war. The purpose here is to introduce some elements of truth.


This article shows a philosophical clarification of the concept of value. The Max Scheler's phenomenological Axiology is very important in order to do so. The article makes two essential corrections to the Scheler's Axiology. These corrections are necessary if you look for the pedagogical applicability of the values.
The theoretical questions are two: the reality of the values (and their connection with the goods and the being) and the knowledge of values. The article shows the relationship between feelings and reason, both are conditions of the possibility of «rationality of the preference».
At the end of the article, shows the problem of the pedagogical transmission of the values, and the theory of models.


Trust in political institutions has declined in recent years. Most explanations for trust in political institutions focus on individual characteristics rather than the variation in trust for different political institutions and the characteristics of those objects of trust. Parliaments in Europe are surprisingly unpopular. For what are often essentially ceremonial institution (a sort of electoral college to choose, but also with the power to remove a government) they receive little of the support some ceremonial parts of the constitution such as monarchy are often afforded. We consider what might explain this and using Ireland as a case, we eliminate some of the explanations suggested for the US. We argue that in Europe a more likely explanation is the media coverage. In particular parliament is the victim of the relationship between politics and the media whereby its openness exposes it to more critical scrutiny. We offer some evidence for this argument with a systematic study of media coverage of Irish politics.


The multimedia synchronization is studied. Firstly, the synchronization mechanism and the synchronization specification of multimedia are introduced. Then the factors disturbing synchronization are discussed. Also, as different methods of synchronization implementations are compared. At the same time four criteria are proposed to identify methods of synchronization implementations. Finally, some typical synchronization approaches are analyzed.


At large research institutions, undergraduate students typically first encounter faculty research as upper‐division students. The Freshman Research Initiative (FRI) at UT‐Austin is a faculty‐initiated reinvention of our undergraduate research paradigm, recruiting over 800 freshmen each year into an integrated three‐semester research‐based course sequence that increases the number and diversity of students engaged in research, and significantly impacts student success and engagement in science. Each year, freshmen are recruited into an eighteen‐month set of courses that promote critical thinking, interaction with faculty, hands‐on experimentation, data interpretation, student presentation, publication, and peer mentoring. One of the 28 different research areas offered to students in the FRI program is the Cell Signaling Lab. Student involvement in the execution and design of original research is the cornerstone of this lab class. The objectives of this lab for freshman students are: to carry out novel experiments and discover new findings on a question of significant current interest in plant biology; to learn methods of experimental design, data gathering, data interpretation, and data presentation; to develop skills of devising alternative hypotheses to interpret experimental results; to learn, through experimentation and data interpretation, basic principles of stimulus‐response coupling in plants. The Cell Signaling class is addressing the question of what signaling steps mediate the effects of extracellular ATP and ADP on the polarized growth of single‐celled root hairs. We will present details about the impact of the FRI program on the academic performance of participating students and discuss the feasibility of having students in a lab class work on a specific question important to the faculty members' research program.


Aim – to establish the morphological manifestations of radiation damage to the liver after exposure to ionizing radiation during irradiation with a betatron 25 MeV, depending on the magnitude of its irradiation, and to study the regenerative capacity of the liver.
Methods. Examined in 83 patients undergoing treatment for cancer of the proximal stomach. In terms of preoperative irradiation on a 25 MeV betatron, a part of the left lobe of the liver fell into the irradiation zone in patients, the total focal dose to it ranged from 8 to 60 Gy. To study the state of the liver after radiation exposure, in addition to monitoring the biochemical parameters of blood, we used radionuclide diagnostic methods – hepatography, hepatoscanning, which were carried out before and after irradiation. The data of hepatoskenograms were compared with histological studies of liver tissues during biopsy at surgery, autopsy.
Results. Depending on the doses received on a part of the left lobe of the liver, there were changes in hepatoscanograms characteristic of radiation hepatitis, up to radiation fibrosis. After irradiation of a part of the left lobe of the liver at a dose of 30 Gy, the changes were reversible and ended in reparation. Changes in the liver at a dose of more than 30 Gy were irreplaceable and ended in radiation fibrosis. According to the data of radionuclide diagnostics, the size of the non-irradiated part of the liver increases, its function compensates for the functional losses associated with dysfunction of the irradiated lobe of the liver.
Conclusion. Irradiation of a part of the liver in doses leading to the development of even radiation fibrosis should not be considered as a contraindication when planning a course of radiation therapy.


The present study aims to examine the effects of operational parameters on the surface topography and wear mechanisms of monolithic and conventional yttria‐stabilized zirconia (Y‐TZP) ceramics in the micro blasting process, performed under various acceleration pressures (1.5–3 bar), particle impact angles (30°–90°), and erodent particle sizes (50–460 μm). Three‐dimensional (3D) surface topography, surface roughness, and surface morphology of micro‐blasted specimens were analyzed by using non‐contact optical profilometry and SEM‐EDS. The micro blasting characteristics of both Y‐TZP were similar that increased blasting pressure and erodent particle size increased surface roughness. Erosion rate increased with increasing blasting pressure, whereas it decreased with increasing erodent particle size. Particle size was the most effective parameter on changing surface topography, while the particle impact angle had no distinct effect on the erosion rate, surface roughness, and surface topography of Y‐TZP ceramics. SEM‐EDS analyses showed that the primary wear mechanism during micro blasting was micro‐cutting with a substantial amount of embedded particles on the material's surface.


PICO question

In cats with feline acne and secondary bacterial folliculitis or furunculosis, is topical or systemic antimicrobial therapy superior for reducing time to resolution and severity of clinical signs?
Clinical bottom line

There is no sufficient evidence to compare topical versus systemic treatment in feline acne with secondary folliculitis/furunculosis.


animal with its broad surfaces cannot possibly be regarded as an echo of the boar's head from the Kuban delta; hence it docs not hav-e to be a later product. The Ordos region has also yieldetl animal sculpturcs in hollow 'casting uch as, for example, the charming bronze hind (FlO. 8). There is little in the way of we tern products which can be compared to them; and there are harePY any animal sculptures of this kind known in China, seen with such tender understanding and yet so soberly, full of natural freshness. Apparent,ly such comprehension is only possible with a profound concern for the life of the animal in the herd or out in the open, a concern felt by the herdsman and hunter, in contrast to the tiller of fields, in whose art the a,nimal appears more as a mythiMI or symbolical creature. Almost all early Chinesc representations of animals are rooted in the mythological, are imaginary and hard to interpret; exceptions are to be found practically only among the small jade sculptures, among which, strangely enough, we find many elements which seem related to the miniature bronzes of the steppes: bird, tiger, stag, animal with turned head, ox head, cicada, coiled animal. U~EXPECTED Ll~K~


The cultural and occupational continuity between Early and Middle Bronze Ages in the Upper Khabur basin, north-eastern Syria has been investigated before with regard to pottery and settlement patterns. This paper addresses the question from the less commonly explored perspective of funerary behaviour and, in particular, material culture represented by grave finds from Tell Arbid in Syria. Material from five child graves dated to the late 3rd millennium BC, presented in this paper, and complementary data on other child graves from the region, provide grounds for discussion. This touches specifically upon jewellery placed in graves. Personal adornments from the late EBA child graves display a strong cultural affinity with those of the 3rd millennium BC, and are indicative of a distinctive social identity for their users. This differs from that of the population that continued to use the same burial ground in the early 2nd millennium BC. The material provides a thought-provoking case for recognizing a break in the cultural legacy between the EBA and MBA despite possible continuity in settlement. Adult burials from the period, which are fewer and mostly devoid of grave goods other than pottery, are largely excluded from the discussion as they do not contribute so effectively to our understanding of these changes.


Bigger's struggle against the inhuman, deleterious cycle of white racism which effectively transforms blacks into their own negative stereotypes of blackness. He revolts against his socially constructed image and a socially assigned role that deny him identity and dignity. His self-perception is governed by the racially prejudiced images imposed on him. Throughout his life, he suffers for being black. The infamy of blackness darkens his existence, making him a victim of white oppression and white racist ideology. With his diminished capacity and depleted sense of self, he tries in vain to disentangle himself from the crippling impact of ideological and racial dominance. The significance of blackness changes for Bigger with the accidental killing of a wealthy white girl. Bigger's personality assumes a new self and his life takes a new turn after the murder, as he attaches new meanings to his black skin. The paper aims to explore Bigger's attempt to attain freedom from the negative self-image by subverting white people's definition of blackness and gain a potential self-hood and meaningful existence.


Photocatalytic reduction of carbon dioxide to hydrocarbon fuel provides a sustainable strategy for addressing the increasing energy crisis as well as alleviating the greenhouse effect. Yet, seeking...


Hypertension is a disease that occurs due to an increase in blood pressure that can cause various complications against several other diseases, even the cause of coronary heart disease, stroke, right ventricular hypertrophy and kidney. Along with the development of the times and technological advances, resulting in unhealthy lifestyle changes in society. Early efforts to prevent hypertensive disease by knowing hypertension risk factors need to be done to prevent adverse events for the community. Therefore, the media needed to make people aware by promoting health promotion informatively. With an informative video is expected to provide information about hypertension to the community. It is also hoped that with motion graphics can be a video informative that is easily delivered with a short and interesting.


Soil pressure of the excavation is one of the important coefficients for dependable and reasonable bracing structure designs.From the theories and the practical engineering conditions,this article mainly analyzes the common factors which can effect the value of soil pressure in design and practice,such as the geological conditions of fillings,the differences of the common earth pressure theories,the effects of the water table,the value of the wall height,the effects of the part over-loading and so on.In conclusion,this article,having certain practical significance,provides some improved means for each factors.


This article discusses the context of the construction of the "Boi Pavulagem" plot, a Boi-Bumba theater organized by the Arraial do Pavulagem Institute in Belem do Para. The article begins with an initial bibliographical review of the Boi-bumba in Para, followed by the description of the context of the Arraial do Pavulagem Institute at the present time. Finally, the relations woven between the plots of the Boi-bumba in Belem and the plot of the trawlers were analyzed. As a partial result of this ongoing research, it could be seen that the plots of the Bois-bumba of Belem are constructed through a dramatic narrative and staged, based on a discourse of tradition and maintenance of ancient characters and rituals, while the processions of the Junino trawler, promoted by the Arraial do Pavulagem Institute, are based on a musical narrative, influenced by the hybridism of musical practices that occur within the Institute, making it more permeable to changes and re-meanings provoked by the current urban sociocultural context.


ZnSe layers of various thicknesses have been grown epitaxially on (001)-oriented GaAs substrates by metalorganic vapor phase epitaxy and studied by x-ray diffraction and Raman scattering. Consistent results have been found for the in-plane strains of both, ZnSe layers below and above the critical value of plastic relaxation. The experimental results are well described by strain profiles which are evaluated by an energy model and a geometrical model including the effects of strain and work hardening. The thickness-dependent full widths at half maximum of the x-ray reflections and the Raman resonances are accounted for by assuming uncorrelated misfit dislocations in the layers.


Research works related to teachers' beliefs and knowledge make a rather disparate set. The very meaning of the concept of beliefs as well as the difference between beliefs and knowledge are controversial. On the other hand the questions concerning the categories of beliefs and knowledge that teachers need when doing their jobs find answers going in the same direction. This article first sums up the major contributions on these subjects. Then it tackles the crucial issue regarding teacher training: Do teachers' beliefs and knowledge change? If they do, on what conditions? Several trends in that research field are examined from that standpoint: research on the changes viewed as "natural", a category in which we add the ones on the development stages of teaching carriers; the studies aiming at measuring the effects of teacher training programmes including for the most part those of initial teacher training; research that is part of a trend called staff development. Part of it is on the young teachers' beliefs because research works on that subject allow to better understand the effects of training programmes. The final debate is linked up around a rather general understanding that it is very difficult to change teachers' beliefs. We examine several assumptions that have been mentioned to try to explain why training processes can't really get through to those beliefs. We then raise the issue that we think is crucial and yet seldom talked about: Are some beliefs better than others? Finally we end the article with a discussion on Leuchter's contributions that allow to re-center the problematic of changes occurring in the teachers' beliefs and knowledge.


Any books that you read, no matter how you got the sentences that have been read from the books, surely they will give you goodness. But, we will show you one of recommendation of the book that you need to read. This the future of theoretical physics and cosmology celebrating stephen hawkings 60th birthday is what we surely mean. We will show you the reasonable reasons why you need to read this book. This book is a kind of precious book written by an experienced author.


There are so many problems in the structure analysis of the Korean traditional wood structures. Among these problems, the uncertainties of the structural properties inherent in various connections may be the most serious problems. Although many analytical or experimental studies discovering structural properties of connections have been performed recently, there are not exact structural property data available in the structure analysis. So, a new research method breaking from conventional analysis, which is like kinematic approach, is necessary to be studied. In this approach, modelling and analysis methods considering the mechanical characteristics of the Korean traditional wood structures are necessary to be developed consistently. Also, it seems that the behaviors of columns are investigated first in this approach. In this case, it is convenient for a column to be modelled as rigid links. So, in this study, a method for transforming rigid link concept using joint displacement constraint to computer program is suggested, which will be used for the analysis of the Korean traditional wood structure column. For this suggestion, a theory for the joint displacement constraint method and the investigation of some commercial programs is done first, then a computer program(sNs) is developed based on the theory and algorithm studied. Lastly, a sample analysis is performed to verify the possibility of application of sNs.


Quality in Health Care is published quarterly. The annual subscription rates are £106 ($166) worldwide for institutions and £65 ($102) for individuals. Rates for individuals are available only on orders placed directly with the publisher and paid for out of personal funds. Orders should be sent to the Subscription Manager, Quality in Health Care, BMA House, Tavistock Square, London WC1H 9JR. Orders can also be placed with any leading subscription agent or leading bookseller. Subscribers may pay for their subscriptions by cheque (payable to British Medical Journal) or by Access, Visa, or American Express by quoting on their order the credit or charge card preferred together with the appropriate personal account number and the expiry date of the card. (For the convenience of readers in the US subscription orders with or without payment ($166 for institutions; $102 for individuals) may also be sent to British Medical Journal, Box 408, Franklin, MA 02038, United States. All inquiries, however, must be addressed to the publisher in London. As a joint marketing arrangement with the RCN Publishing Company Quality in Health Care is available to members of the Royal College of Nursing at a reduced rate.


Experts consider the tax consequences of separation and divorce including, transfers between spouses, principal private residence relief and retention of assets with locked-in gains.


Background: For early detection of schizophrenia, we investigated the factors influencing young adults at clinical high risk (CHR) of psychosis and explained the structural model based on the Adolescent Resilience Model and the Stress Vulnerability Model. Methods: Based on web-based questionnaires, we measured perceived stress, family adaptability and cohesion, social support, coping, resilience, social function, and CHR in 907 cases. Results: Among 907 subjects, 102 (11.3%) were classified as CHR, and there was no difference according to demographic variables. Influencing factors of CHR were perceived stress, resilience, and social function. In the modified model, perceived stress, family adaptability and cohesion, and social support demonstrated a significant effect on coping. Perceived stress, family adaptability, cohesion, and coping demonstrated a significant influence on resilience. Perceived stress, coping, resilience, and social function demonstrated a significant influence on CHR. Conclusions: We suggest future research on the early stages of adolescence, and research that includes face-to-face surveys. Moreover, we recommend the development and selection of tools that can explain each influencing factor more lucidly.


Highly effective teachers need to transform a man from a sensuous being to a human being. Only self-actualized teachers can make maximum development of human resource. But, do you know the level of their self actualization in relation to socio-economic status and job-satisfaction. In fact, the study aimed to find out the levels of self-actualization, socio-economic status and job-satisfaction of University and College teachers. Self-actualization scale, Socio-economic status scale and Job-satisfaction scale used to collect the data from 100 University teachers and 200 College teachers whom were selected through simple random sampling technique. The study assumed that there would be high levels of self-actualization, socio-economic status and job-satisfaction of university and college teachers. Percentage and Kruskal-Wallis H Test used to analyze the data and to draw the inferences about the level of self-actualization, socio-economic status and job-satisfaction of University and College teachers. It resulted that the level of self-actualization, socio-economic status and job-satisfaction of both University and College teachers were high.


A survey on the occurrence of ochratoxin A (OTA) in 240 grape-based beverages was carried out. Red and white wines from four different Spanish Designations of Origin (n = 160), musts (n = 20), grape juices (n = 10), ordinary wines (n = 20), special wines (Malaga, muscatel, sherry, vermouth, etc) (n = 20) and sparkling wines (n = 10) were assayed for OTA content using immunoaffinity column clean-up and high-performance liquid chromatography with fluorimetric detection (detection limit 0.05 µg l−1). Forty-three (17.9%) of the samples tested contained detectable levels of OTA. The overall mean OTA concentration in red and white wines of Designations of Origin was 0.30 and 0.18 µg l−1 respectively (ranges 0.05–3.19 and 0.05–1.13 µg l−1 respectively). The percentage of wine samples with detectable amounts of OTA was higher for red (18.3%) than for white (10%) wines. OTA was also found in two of 10 red ordinary wines (0.68 and 4.24 µg l−1), whereas none of 10 white ordinary wines contained OTA. The mean OTA amount detected in sparkling wines was 0.44 µg l−1 (range 0.14–0.71 µg l−1). Two of 20 must samples contained OTA at low levels (0.08 and 0.18 µg l−1), while none of 10 grape juice samples contained OTA. Highest amounts of OTA were found in special wines (45%), with a maximum of 15.25 µg l−1 in a muscatel sample. Copyright © 2004 Society of Chemical Industry


It was predicted that the effects of food deprivation upon spontaneous aggression in rats would be to increase the likelihood of victory. The results indicated, however, that deprivation decreased the chances of winning. The effect of deprivation upon exit latencies from the home cage was to decrease latencies. A tendency was noted for victorious rats to have shorter exit latencies than defeated rats.


Splicing including homogenous splicing and heterogeneous splicing is one of the most common ways to tampering digital audio. This paper focuses on the study of heterogeneous splicing. Since different audio is recorded at different background environments, there exist significant differences in background noise level for different recorded audio. In this paper, the level of background noise is used to detect the splicing tampering in audio. However, unlike other methods that use background noise level for tamper detection, we do not detect background noise level after continuous framing. In order to more accurately determine the location of tampering, we first need to determine the length of each syllable in the audio using endpoint detection method. Here, we use the spectral entropy method to determine the length of each syllable. Then the variance of background noise of each syllable is calculated according to the kurtosis value characterized the number of peaks in the density distribution curve at the mean that is close to a constant in the band-pass filtered domain. Finally, by comparing the similarities between the variance of background noise of each syllable, it is judged whether there is an operation of heterogeneous splicing tampering in the audio. Our algorithm can accurately locate the heterogeneous splicing syllables.


Epidemiological studies on birth defects and blindness that may be of research or practical value to blindness workers are surveyed. Two of those studies, the Collaborative Perinatal Project and the Birth Defects Monitoring Program, both federally operated, were described to a recent American Foundation for the Blind "Research Seminar on Birth Defects/Blindness and Severe Vision Impairment." * Recent advances in genetic counseling and genetic diagnosis–particularly fetal diagnosis through the study of fetal cell samples obtained by amniocentesis–are explored as new tools through which blindness workers can assist clients who may wish to minimize their risk of bearing a blind or otherwise defective baby, through therapeutic abortion of afflicted fetuses.


The quality of satellite Precipitable Water Content (PWC) moisture data is assessed by comparing them with radiosondes and the first-guess humidity field from the ECMWF operational model. Collocation studies show that PWC data from satellites are of comparable quality to radiosonde data and that the error in the inferred relative humidity varies from 15% in the Tropics to 35% in the extra-tropics, similar to the typical error levels of radiosonde humidity data. The model first-guess provides moisture information of comparable accuracy. Using a large sample of radiosonde and first-guess moisture information over North America, the typical forecast error correlation scale for the humidity analysis variable has been found to be 250 km at the surface rising to 300 km at upper levels. Finally, impact studies have shown that the inclusion of satellite PWC data in the ECMWF humidity analysis has a small but beneficial impact on the forecast, especially of the forecast rain in the Tropics. DOI: 10.1111/j.1600-0870.1989.tb00386.x


AIM To investigate the effects of iptakalim hydrochloride (Ipt) on cerebral neuronal sodium, calcium and potassium channels. METHODS The effects of Ipt on sodium, calcium and potassium channels in cultured hippocampal neurons was observed using whole-cell recording technique. RESULTS Ipt had no significant effect on Na +, Ca 2+ currents, but significantly increased the outward K + currents. This enhancement of Ipt was inhibited by synchronously application of glibenclamide. Upon the administration of Ipt 1, 10, 100 μmol·L -1, the outward K + current was significantly increased to (121.9±8.1)%, (114.7±7.1)%, (109.1±10.0)% respectively (n=6~9, P0.01~0.05). This enhancement of Ipt was inhibited by synchronously application of glibenclamide 30 μmol·L -1, a relatively specific inhibitor of ATP-sensitive K + channels. CONCLUSIONS Iptakalim hydrochloride, with no significant effects on sodium and calcium channels, could activate ATP-sensitive potassium channels selectively.


A high-pressure microwave digestion was applied for microwave-assisted extraction (MAE) of mercury species from sediments and zoobenthos samples. A mixture containing 3 mol L −1


The COVID-19 pandemic increased the rate of mental health disorders, as well as demand for mental health services. It remains unclear, however, the extent to which the pandemic impacted access to mental health services. Using data from an audit field experiment, we examine the impact of COVID-19 on access to mental health care appointments in the United States. This experiment ran from January to May 2020 and overlapped with the initial onset of the COVID-19 pandemic. We find that increased intensity of COVID-19—measured by daily cases, daily fatalities, and weekly excess deaths—is associated with decreased access to mental health care appointments.


A mechanism of underwater AC discharge in capillary and its spectral characteristics are investigated. It is revealed that duration of emission of OH radicals and Hα is about 650-850 μs and Na atoms radiation is 250 μs. Physical process explaining delay of Na emission appearance in the spectrum of the discharge is suggested. It is well agreed with experimental data.


I N his book Philosophical Style, Professor Blanchard gives an amusing illustration of the licence which we have come to allow philosophers in their treatment of the King's English. Speaking of a young philosopher, he says : 'He is writing a book on metaphysics; (and) the clearness with which he thinks he understands and his total inability to express what little he knows will make his fortune as a philosopher'. But have we, on the other hand, any right to demand from a philosopher that sensitivity to language which we demand from the educated layman or, more especially, from the poet and the novelist ? It is strange at a time when all British and many continental philosophers are so excessively preoccupied with the analysis of language that philosophy should be so badly written. We are put down by such expressions as 'ought-statements', 'topic-neutral', 'first-order propositions', and we are provoked into assuming that this use or abuse of our language indicates not a special sensitivity to it but the reverse. Are there any truly philosophical grounds for exploring such a prejudice? I believe there are and that Coleridge's warning in the Biographia Literaria needs to be heeded by the contemporary philosopher: 'language is the armoury of the human mind; and at once contains the trophies of its past and the weapons of its future conquests'. In fairness to the philosophical party in power, it is important to remember why a philosopher is bound to have difficulties with language of a kind quite peculiar to his occupation, for philosophical thinking is uniquely reversible. This is because the philosopher is in the position of one who goes over the ground twice and his knowledge is not of something we did not know before, but of something we had known all along and now come to see in a new light. We gain this knowledge when we are obliged to examine some well-worn statement such as 'we are free to act', or


The air quality for 2001 is found to strongly resemble that for 2000.
The decreasing trend in concentrations seen in the nineties, is still
valid on the whole. Concerning the meteorological influences, 2001 can
be considered as a normal year. Widespread exceedances occurred for
ozone and PM10, and in the deposition of potential acid and total
nitrogen. In the urban environment, exceedances of the annual mean limit
value for NO2 occurred along road length of about 2000 km. Calculations
for benzene and benzo[a]pyrene showed that exceedances were incidental.
This annual air quality survey provides an overview of the air quality
and the load placed on soils and surface water by atmospheric deposition
in the Netherlands, on the basis of measurements and model calculations.
The report describes global, photochemical, acidifying, particulate and
local air pollution. Special attention has been paid to the Dutch air
quality in relation to the new European legislation on air
quality.


In the recent decade, it has been discovered that QKD systems are extremely vulnerable to side-channel attacks. In particular, by exploiting the internal working knowledge of practical detectors, it is possible to bring them to an operating region whereby only certain target detectors are sensitive to detections. Crucially, the adversary can use this loophole to learn everything about the secret key without introducing any error to the quantum channel. In this paper, as a step toward overcoming detector blinding attacks, we focus on an experimentally convenient countermeasure, where the efficiency of the detectors is randomly varied.


Development of simulation models of the effects of elevated CO{sub 2} on plant physiological processes requires close cooperation between modelers and experimentalists. In particular, the detailed process-based, leaf-level photosynthesis model currently in development at San Diego State University requires parameterization data for different plant species, levels within the canopy, and growth conditions. Validation of model predictions will require additional data. The purpose of this supplemental is to initiate ways in which different groups involved in elevated CO{sub 2} research can interact to advance the goals of both the individual research scientists and the CO{sub 2} Research Program.


Objective To analyze the characteristics and regularity of adverse reactions of traditional Chinese medicine(TCM) injections in our hospital in 2009-2010,and provide basis and reference for clinical rational drug use.Methods TCM injection ADR occurred in our hospital during January 2009-November 2010 were analyzed.Results TCM injection ADR accounted for 11.63%,and the major clinical manifestations of it w ere rash,shivers,fever,reactions of injection site,chest tightness,etc.Conclusion The adverse reactions of TCM injection are common,and the monitoring should be emphasized to ensure safe drug administration.


From exoskeleton to the remote teleoperation, the development of patents related to space exploration later provided significant opportunities in many fields of sciences such as medicine, robotics, underwater expeditions, hazardous work, industrial assembly, and even during everyday work as mowing. Antal K. Bejczy the Hungarian born innovator was working on the technical part of these projects, under his work at JPL the technology turned over to private industry, like the remote control. Bejczy and the college's evaluation report was used by the Johnson Space Center Space Shuttle Arm's research in 1984. The focus of the report from 1982 was the Evaluation of smart sensor displays for multidimensional precision control of Space Shuttle remote manipulator.


The main aim of this diploma work is to reconstruct geometry from the old records of cadastral
surveying data and to estimate the positional and geometric accuracy of the cadastral index map in the
cadastral municipality of Cresnjice in the city municipality of Novo mesto. The scope of the research
work was, among the others, to study approaches, how the land surveying (cadastral) data can be
integrated in the processes of the positional and geometrical quality improvement of cadastral index
maps. It is explained, how we processed the land surveying data from the period 1974–1990; here,
some particularities are outlined, which have to be considered by processing of land surveying data
from the study period. Each of the 6 selected cadastral documentations is presented separately. In the
conclusion, the discussion is added if such data are appropriate for improving the positional and
geometrical accuracy of the cadastral index map.


The destructive potential of earthquakes depends on their magnitude and the placement of the hypocenter. Worldwide efforts in establishing seismological and geophysical networks has increased considerably and data centers provide information that is essential to identify earthquake locations, understand the physics of the earthquakes and faulting mechanisms, as well as studies on site effects and earthquake recurrence. These types of studies play a key role in mitigating earthquake hazards and planning emergency response. However, recent earthquakes demonstrated the risks to modern societies, especially in terms of health, safety, and economic viability. The study of earthquakes combines science, technology, and expertise in infrastructure and engineering in an effort to minimize human and material losses when their occurrence is inevitable. Although probably the most important, direct shaking effects are not the only hazard associated with earthquakes, other effects such as landslides, liquefaction, and tsunamis have also played important part in destruction produced by earthquakes. Most earthquake-related deaths are caused by the collapse of structures, and the construction practices play a tremendous role in the death toll of an earthquake. As an example among the others, in the Messina area (southern Italy), more than 120,000 people perished in an earthquake (M = 7.2) that struck the region in 1908, mainly killed due to the easily collapsible structures that dominated both the major cities and villages of the region. A larger earthquake that struck San Francisco three years earlier had killed fewer people (about 700) because building construction practices were less vulnerable and predominantly made by wood. In both areas, these events played a key role in the future of the region. Recently, on January 12, 2010, disaster struck Haiti and its economy, as well as its surrounding nations. Death totals topped 200,000, and reliable industries and structures were destroyed, leaving the nation in a tough situation. It remains clear that the earthquake that has recently stuck Haiti has had a catastrophic impact on Haiti, leaving its economy in shambles. In the last decades, other important examples of catastrophic events are the great Sumatra earthquake (December 26, 2004) and the Japan earthquake (March 11, 2011) associated also with tsunamis of notable energy that caused


Background: To explore the impact of agronomic practices on nodulation, nitrogenase activity and biological nitrogen fixation in hybrid pigeonpea, a field investigation was under taken at BW5 block ICRISAT development center (IDC), International Crops Research Institute for Semi-Arid Tropics (ICRISAT), Patancheru, Hyderabad, during kharif, 2021 and 2022. Methods: The seedlings were raised in portrays in advance to onset of monsoon during last week of May (28th May in 2021 kharif and 30th May in 2022 kharif) in both the years by filling portrays with cocopeat and vermicompost in 1:1 ratio. Transplanting of 24 days and 25 days old seedlings were done on 20th June in 2021 kharif and 23th June in 2022 kharif, respectively, on the same day of dibbling in the main field at 100 cm × 100 cm ,120 cm × 120 cm square geometry and 150 cm × 60 cm. Nutrient management treatments were imposed one week after sowing. Result: Among the planting methods higher nodule number and nitrogenase activity with transplanting compared to dibbling. 120 cm × 120 cm found higher nodule number plant-1 and nitrogenase activity but biological nitrogen fixation was higher with 100 cm × 100 cm ha-1 basis. With respect on nutrient management practices, control performed well in terms of higher nitrogenase activity and biological nitrogen fixation and on par with integrated approach of 100% soil test based NPK + vermicompost + PSB + seed treatment with Rhizobium. So, with transplanting method of establishment, 100 ´ 100 cm square plant geometry and 100% soil test based NPK + vermicompost + PSB + seed treatment with Rhizobium was recommended agronomic practices for hybrid pigeonpea.


With the continuous development of international economic exchange, the economic globalization level is increased day by day and the economy globalization development has expressed requirements on the accounting internationalization during this process. This paper firstly explains the close relationship between economic globalization and accounting internationalization and future discusses the development strategy of accounting internationalization under the environment of economic globalization in order to further promote the international economic exchange. Keywords—economic globalization; accounting internationalization; accounting principle


The study was conducted to determine the travel and tour preferences of millennials in Batangas State University Malvar Campus. Specifically, the study described the profile of the respondents in terms of sex, age, educational attainment, and occupation; determined the millennials' travel and tour preferences in terms of service, accommodation, and promotion; and tested if there was a significant relationship on the travel and tour preferences when the respondents were grouped according to their profile through descriptive research method. The respondents were millennials, employees and students at Batangas State University Malvar Campus. The results reveal that majority of the respondent millennials are in age of 18-23 years old; majority are females, majority are high school graduates; and most of them are students. With regard the assessment of respondents' service, accommodation, and promotion, the study also reveals that the millennial respondents are psychocentric type of travelers. The information material guide as output can be used by the travel and tour agencies, in a form of brochure, leaflet, and flyers that covers the millennial travelers' preferences.


This paper presents estimates of the parameters under step-stress partially accelerated life testing in the presence of censored data from generalized exponential distribution. The maximum likelihood procedure is used to derive point and asymptotic confidence interval estimations of the unknown parameters. Also, confidence bounds based on the log likelihood ratio are explored. The performance of the estimators is investigated numerically for different parameter values and different sample sizes in terms of their mean square error. A simulation study is made for illustrative purposes.


In this paper, stochastic properties of solution for a chemostat model with a distributed delay and random disturbance are studied, and we use distribution delay to simulate the delay in nutrient c...


E. Chassaing, J.-F. Guillemoles, and D. Lincot Institute of R&D on Photovoltaic energy, (IRDEP), (UMR 7174 EDF-CNRS-ENSCP ParisTech), 6 quai Watier, F-78401 Chatou Cedex This paper presents a general view of the electrodeposition of semiconductors, focusing on chalcogenides (CdTe, Cu(In,Ga)(Se,S)


Objective To observe the effects of HBO combined with comprehensive drug treatment on 58 cases of acute face neuritis.Methods In accordance with the case selection criteria,116 case of acute face neuritis were chosen for the study.With the knowledge and consent of the patients and following the signing of the letter of agreement and with the agreement of the Hospital Ethic Committee,1 16 patients were divided into 2 groups:the experimental group and the control group,each consisting of 58 patients.The patients in the control group were only treated with regular drug treatment,while the patients in the experimental group were offered HBO treatment and regular drug treatment as well.They were all treated for a succession of 3 weeks and observation was made on the therapeutic results of both groups.Results After 3 weeks of treatment,facial nerve function scores for the patients of both groups all increased when compared with those before treatment,with statistical significance (P < 0.01).Scores for the patients in the experimental group were significantly higher than those for the patients of the control group (P < 0.05).Conclusions Comprehensive HBO treatment seemed to produce significant effects in the treatment of acute face neuritis.

Key words:
HBO treatment;  Acute face neuritis;  Therapeutic effect


Abstract : Monkeypox virus (MPXV) is an emerging/re-emerging zoonotic infection endemic to Central Africa that produces a human disease similar to smallpox. Since the cessation of active vaccination and the global eradication of smallpox, monkeypox has emerged as a potential biological threat due to the vast number of unvaccinated individuals worldwide. Given the adverse events associated with current vaccination strategies, and a lack of fully licensed therapeutic options, there has been sustained interest in countermeasure development, testing, evaluation, and implementation. The continued development of animal models to replicate human disease has been crucial for therapeutic evaluation, and while no current model recapitulates all the features of human disease, nonhuman primate models have come close. Here, we describe the construction of a new double recombinant fluorescent monkeypox virus (MPXV-GFP-tdTR), validate its use for therapeutic evaluation in vitro, and demonstrate its pathogenicity in nonhuman primates. The data support the prospective use of this virus for future animal model development and therapeutic evaluation studies.