Abstract:Against Nancy Armstrong's recent contention that contemporary novelists have "declared the household obsolete as a way of imagining national community," I analyze Kamila Shamsie's attention to fractures in the nation-state in the era of transnational mobility and affiliations in Home Fire (2017) and Burnt Shadows (2009), works that make the household central. I argue that what initially seems a paradoxical figure for exploring the transnational actually proves able to capture key features of transnationalism and of the attendant transformation of liberal-democratic states in the current moment. Rather than serving to naturalize the political constitution of the liberal democratic state and banish ascriptive distinctions and exclusions to the periphery of the domestic imagination, in Shamsie's hands the household serves both as utopian counter-narrative and as a means of tracing the long history of the liberal state's repressed and intimate violence up to the entrenched divides and political impasses of our current moment.


In the first part of this round table discussion, the following improved recovery methods were covered: thermal methods, miscible displacement, and injection of specially treated water. In the second part on new resources, geophysical techniques, special studies of carbonate rocks, and an evaluation of the ultimate resources which will be discovered were the topics of discussion. A special item discussed was the economic context and its influence on the total volume of recoverable reserves; not only the technology, but also the net income left to the producer after costs and taxes will determine what percentage of the technically recoverable reserves will actually by produced. Obviously, these factors also depend on the size of the deposit.


Treatment outcomes are suboptimal for patients undergoing endoscopic treatment of walled‐off pancreatic necrosis (WOPN). The objective of this study is to identify factors that impact treatment outcomes in this patient subset.


In this book, which is part biography, part narrative history, the author narrates the life and times of a devout eighteenth‐century evangelical woman. Locally famous in her own day for her religio...


Understanding the effect of nitrogen addition on species trait–abundance relationships is one of the central focuses of community ecology and can offer us insights into the mechanisms of community assembly under atmospheric nitrogen deposition. However, few studies have focused on desert ecosystems. In this study, we measured the abundance and ecological stoichiometric traits, leaf carbon content (LCC), nitrogen content (LNC), and phosphorus content (LPC) for all annual ephemerals in all plots subjected to nitrogen addition in early spring in Gurbantunggut Desert, northern Xinjiang, China. We found a significant relationship between traits (LNC, N:P, and C:N) and abundance, indicating that ecological stoichiometry is a good proxy for explaining and predicting species abundance. We further found that significant trait–abundance relationships still existed under different nitrogen addition levels. The result suggests that trait-based niche-assembly theory plays an important role in determining species abundance under atmospheric nitrogen deposition.


We present a first practical application of "Procedure for air quality models benchmarking" PROBENCH for FMI-regulatory models benchmarking , provide example evaluation results based on archived model and measurement data and finally discuss the added value this benchmarking procedure provides compared to regulatory modelling and model development.


A digital phase comparator has been developed that is especially well suited to making precision phase measurements at high frequency. The circuit consists of two standard phase comparators that are interconnected so that their outputs are averaged to give the desired phase measurement. A clipping circuit consisting of back-to-back Schottky diodes is used to square up the output pulses, which improves the linearity. A variable-modulus digital prescaler is used to change the range from ±1 fringe to ±32 fringes. Instruments using this circuitry are being used to measure transient phase signals from a microwave interferometer that measures the plasma line density on the magnetic-fusion tandem mirror experiment. The resolution is less than 0.1 degree at a carrier frequency of 40 MHz with a maximum nonlinearity of ~0.5%.


In New Mexico, all male juveniles sentenced to serve time in a state facility eventually go to the New Mexico Boys' School (NMBS), including males who are candidates for a reintegration center. The current study compares a random sample (n = 98) of youths released from the NMBS with a group (n = 92) who completed a reintegration program. Two key questions guided the research: (1) What role do personal-biographical or socio-legal factors play in the decision to assign a youth to the reintegration center rather than to have him remain at the Boys' School? and (2) Among juveniles who participated in either program, what personal-biographical or socio-legal factors provided the greatest insights into the length of their stay in state custody? By addressing these questions, the current study not only examines institutional decision-making processes, but also addresses the outcomes that result from the decisions. The policy implications of both the processes and the outcomes are addressed in this article.


A model system for theory and experiment that is relevant to foam fractionation consists of a column of foam moving through an inverted U-tube between two pools of surfactant solution. The foam drainage equation and its variants are used for a theoretical analysis of this process. In the limit in which the lengths of the two legs is large , exact analytic formulae may be derived for the key properties of the system. Numerical computations and experiments support these results.


Abstract In tractor seat design, the properties of most cushion materials specified by the manufacturers are based upon static test method. The in-service mode of a tractor, however, is dynamic rather than static. Therefore, the overlooked real time dynamic properties of seat cushion materials are of greater importance for tractor operator comfort than static properties such as density and force–deflection. In this study, an indentation force–deflection indentor was used to load seat cushion materials under a dynamic mode, comparable to actual loading conditions in tractor operation. This test provided several real time properties such as mean dynamic loaded and unloaded height, dynamic modulus, dynamic hysteresis, and support factor in a relatively short period of time (8 h). It was observed that dynamic loaded height, unloaded height and dynamic hysteresis decreased with flex time while dynamic modulus and support factor increased with flex time for most of the seat cushion materials. The synthetic rubber foam cushion materials D (thickness of 54 mm, density of 68·70 kg m −3 ) and 1·9D (thickness of 101 mm, density of 69·72 kg m −3 ) may be recommended for tractor seats on the basis of real time properties. The measurement of real time properties of seat cushion materials will help to reduce the need for extensive and rather costly field evaluation of tractor seats.


Background: The study was carried out to determine the amount of the dolomite phosphate rock (DPR) on the growth and seed yield of black sesame in a paddy field. Methods: A randomized complete block design was used for the field experiment, which included four treatments, each with four replications. Treatments were applied without the DPR and with 0.25, 0.5 and 1.0 t ha-1 DPR. Result: Experimental results showed that sesame plants were fertilized with the following formula: 60 N x 60 P2O5 x 30 K2O kg ha-1. Moreover, the addition of 0.5 t ha-1 DPR increased plant height (129.7 cm), the number of leaves and pods per plant (47.4 pods), total chlorophyll content in leaves (12.4 µg/cm2), the number of seeds per pod and seed yield (1.61 t ha-1). The phosphate content increased in the stem but not in the leaves and seeds. The pH of the soil (0-20 cm) and the amount of NH4+, NO3- and PAvailable were also increased.


Agile software development by offering new values motivates software companies to use Agile methods instead of traditional methods. However, reviewing the literature shows that leaving traditional methods and moving to Agile methods is subjected to many serious challenges. We have conducted a large-scale research study to empirically discover various aspects of Agile transformation. Our Grounded Theory study showed the general outline of Agile transformation. The main aim of this paper is to figure out the most important concepts that need to be considered when moving to Agile. This study showed that Agile transformation comprises many concepts, activities, and steps including transformation prerequisites, facilitators, framework, assessment, coaching, and so on. Companies need to be familiar with these concepts before starting transitioning to Agile.


As the discharge capacity and average discharge voltage is kept at about the initial value for thousands of cycles, the lithium ion battery to take advantage of the appropriate ratio of the discharge cycling capacity is activated, then it is possible to cycle. Relatively high discharge speed, and with respect to practical battery formats are realized excellent cycling performance. Further, before performance of a lithium ion battery, the battery is partially activated, can be realized with excellent cycling performance, whereby the discharge capacity and average discharge voltage is lowered by more than 20% from the initial value , it is possible to utilize the good discharge capacity for thousands of cycles. The positive electrode active material can be lithium-rich metal oxides. Activation of the battery may include a phase change of the active material. As described herein, a phase change, while providing very good cycling stability, can be manipulated to make available the appropriate proportion of high available capacity of the material.


In the conditions of market economy real estate administration submits to the law of the demand and supply. The market determines the level of rates of lease and the price of the offered services. At the same time the solvency of consumers limits the demand, and the level of development of national economy the offer. In its turn, real estate administration submits to general laws of a management activity. This law should be as a special case of management, purposeful and systematic impact of the subject on its object in achievements of interests of both parties, and also maintenance of a condition of effective functioning of an object according to its criteria set by subjects of management. Studying theoretical fillings of regulation of real estate, especially its concept and objects of management the author proved that the main problem of business activity is the maximum accomplishment of all transactions connected with the real estate: investment, construction, realtor, ownerships and uses, mortgage and exchange, trust management. Accepted by National association of managing directors of the real estate of the Russian Federation, standards characterize system of a legislative and standard regulation; control of behavior of all subjects of the real estate market, performed by state bodies; registration and registration of title and other documents for real estate objects, and also management of real estate objects for the benefit of the owner. At the modern market of services the principles of real estate administration in many respects depend on political and economic conditions in the country, but at the same time they must consider developed international experience. Achievement of the formulated purposes is possible when accounting of the existing principles of management at the Russian regional markets. Introduction of rather high rate of the real estate tax leads to the fact that the owners incapable to manage the real estate can't pay a tax and finally have to sell it. Thus, the high rate of the real estate tax leads to transition of the real estate to hands of more effective owners.


Abstract Work-life balance (WLB) issues are taking centre stage in the work and family policies in Kenya. This is due to the diversity of the current workforce that includes high proportions of working women. This article reports on a study that sought to find out how the print media frames the definitions and causes of, and solutions to, WLB issues in Kenya. The study found that the media frames WLB as a middle-and upper-class families' women's issue. Thus, WLB is depicted as unattainable and women's work is framed as their choice made for selfish ambition. This framing places working mothers at a disadvantage. Women are perceived as primary caregivers with roles that cannot be delegated. There is also less support from their spouses and employers and more reliance on domestic workers. The study found the following solutions to WLB challenges: (1) reframe women's role to be inclusive of work; (2) include nurturing roles to expand the role of fathers and husbands; (3) improve women's relationship with their domestic workers; (4) encourage women to pace life accordingly; and (5) advise women to plan and have better time management. Policy implications are also discussed in detail in the article.


No single mechanism can be expected to give optimal retrieval in all cases in information retrieval (IR) context. Many problems have been reported concerning the difficulty of making the right choices at the design stage of information retrieval systems. This paper presents a flexible model of information retrieval process together with a mechanism exploiting query typologies for instantiating the flexible model. The proposed model integrates in a single framework various alternative information retrieval primitives. This is possible thanks to attaching to every primitive strategic parameters which express different alternatives. We show how the parameterized model can be combined with a Case-Based Reasoning (CBR) approach to incrementally improve an information retrieval strategy. The proposed approach fulfils a synergy between CBR and information retrieval which aims to exploit users feedback for improving the retrieval short-term (during a single retrieval session) and long-term performances (over the life time of the system). This approach allows incremental learning of the right use of a generic model as well as exploiting success or failure of information retrieval. This is achieved by managing a memory of prior search sessions. A working prototype exists and evaluation is in the initial phase. However we anticipate some difficulties during the evaluation due to interactivity in IR process and we give a prospective study of how the performances will improve.


Optical properties of ferromagnetic half-metallic full-Heusler Co$_{2}$FeGe alloy are investigated experimentally and theoretically. Co$_{2}$FeGe thin films were obtained by DC magnetron sputtering and show the saturation magnetization at $T$=10 K of $m\approx$5.6 $\mu_{B}$/f.u., close to the value predicted by the Slater-Pauling rule. First-principles calculations of the electronic structure and the dielectric tensor are performed using the full-potential linearized-augmented-plane-wave method in the generalized gradient (GGA) and GGA+U approximations. The measured interband optical conductivity spectrum for the alloy exhibits a strong absorption band in the 1 - 4 eV energy range with pronounced fine structure, which agrees well with the calculated half-metallic spectrum of the system, suggesting a near perfect spin-polarization in the material.


Abstract Since the beginning of the 21st century, our knowledge of the sources and fate of Hg over the Tibetan Plateau (TP), the "Roof of the World," has been greatly enhanced with growing literature. Here, we reviewed the available literature to obtain a comprehensive understanding of Hg biogeochemistry over the TP. The biogeochemical Hg cycling is characterized by the following features: (1) There are existing but limited local emission sources of anthropogenic Hg in the TP. The Indian Summer Monsoon is an important transporter of atmospheric Hg pollution into the inland TP; (2) "Cold trapping effect" plays an important role in the atmospheric Hg deposition over the TP. Glacier, vegetation, and soil act as important "sinks" of atmospheric Hg pollution; (3) Enhanced anthropogenic activities around the TP, climate warming and glacier melting have the potential impacts to affect the behavior and distribution of Hg; (4) Significant bioaccumulation of MeHg (>100 ng/g) has been found in the Tibetan aquatic food chains. Considering that transboundary transport is responsible for the widespread Hg pollution in the TP, international/regional collaborations regarding Hg emission regulations are needed to reduce the migration of Hg and to mitigate adverse Hg pollution impacts on the TP.


SITUATION YourTel is a company that promotes longevity. Most of the executive board has been with the company for at least fifteen years. The company tends to prefer employees from Arkansas who would tend to share the same corporate cultural values. Jordan Ashe has been with YourTel since 1972 having started as director of accounting. He was promoted to his current position of President and Chief Executive Officer in 1989. He is responsible for the continued growth that the company has sustained. Growth has been phenomenal; starting with several small rural telephone companies and growing into one of the top fifty telecommunications companies. Under Jordan's tutelage, the company has experienced ten years of record earnings until last year. Toward the end of 1999, stock prices have begun to slip and stockholders are unhappy with the decrease in earnings per share. CEO Ashe has called an executive meeting to address the stockholder concerns. The first to arrive is Joshua Townsend who joined YourTel in 1989 as Vice President of Operations. His responsibilities include operation and management of billing and revenues, government relations, and customer service areas. He is also in charge of the company's wireless operations. He has a bachelor's degree in accounting and a master's degree in business administration from Arkansas State University. He has expressed concern in past meetings for what he terms YourTel's timid approach to wireless communications expansion. Townsend's arrival is closely followed by Aaron Johnson, Chief Administrative Officer, joined YourTel in 1987 as General Counsel. His duties include responsibility for Human Resources. Johnson has a degree in law and is a member of the Arkansas State Bar Association. He has a tendency to stay outside the discussions until they affect his area of responsibility. Blaine Blumgren, Executive Vice President and Chief Financial Officer, arrives for the meeting. Blumgren was employed at YourTel in 1985 as Vice President of Finance. He responsibilities include the negotiation of purchase agreements. He manages YourTel's accounting, treasury, financial planning and analysis, and corporate development. He has taken a lot of the heat for the slight decline in sales by the company. He believes that the new information system has had an impact of profits. John Allenby is the newest member of YourTel's board. He joined the company in 1998 as Vice President and Chief Information Officer. He is charged with maintaining the company's entire information systems. He is not new to the telecommunications area, having previously worked for Bell and Lucent Technologies. As the newest member of the executive committee, he is still finding his way into the group. Some of the board members has shown a inclination toward caution in respect to company strategy and resist anything new which they feel is unproven. He is still defending his overhaul of the information system used by the company which, in his opinion, was badly needed. He has seen the results starting to turn around and has the figures to prove it with him. He doesn't like to be broad-sighted so he has come prepared, as he usually does. The company has been doing rather well. Even with the recent dip in the price/earnings ratio, the company has maintained a respectable posture. Stock prices have leveled but there is concern with the lack of exponential growth that the stockholders are accustomed to seeing, especially when other telecommunications companies are doing so well. Just wrapping up the fourth quarter of 1999, Jordan Ashe said, "YourTel finished 1999 with excellent customer growth. For the quarter, YourTel added 16,600 wireless subscribers, 38,200 long distance customers and 2,700 Internet customers." With the whole world going "cellular," the company has decisions to be made about future growth. Ashe ponders whether past strategies will result in a continuation of YourTel's stellar growth or if bolder approaches are needed. …


ICISC 2013, the 16th International Conference on Information Security and Cryptology, was held in Seoul, Korea, during November 27–29, 2013. This year's conference was hosted by the KIISC (Korea Institute of Information Security and Cryptology) jointly with the NSRI (National Security Research Institute), in cooperation with the Ministry of Science, ICT and Future Planning (MSIP). The aim of this conference is to provide an international forum for the latest results of research, development, and applications in the field of information security and cryptology. This year we received 126 submissions from more than 20 countries and were able to accept 31 papers from 14 countries, with an acceptance rate of 24.6 %. The review and selection processes were carried out by the Program Committee (PC) members, 86 prominent experts worldwide, via the IACR review system. Submissions by Program Committee members received at least five reviews. The review process was double-blind, and conflicts of interest were handled carefully. The conference featured two invited talks: "Making NTRUEncrypt and NTRUSign as Secure as Worst-Case Problems over Ideal Lattices" by Damien Stehlé and "Introduction to Quantum Cryptography and Its Technology Trends" by Jeong Woon Choi. We thank the invited speakers for their kind acceptance and nice presentations. We would like to thank all authors who submitted their papers to ICISC 2013 and all of the 86 PC members. It was a truly great experience to work with such talented and hard-working researchers. We also appreciate the external reviewers for assisting the PC members in their particular areas of expertise. Finally, we would like to thank all attendees for their active participation and the organizing team who nicely managed this conference. We look forward to seeing you again at next year's ICISC.


We review in this article the current theoretical understanding of collective and single particle diffusion on surfaces and how it relates to the existing experimental data. We begin with a brief survey of the experimental techniques that have been employed for the measurement of the surface diffusion coefficients. This is followed by a section on the basic concepts involved in this field. In particular, we wish to clarify the relation between jump or exchange motion on microscopic length scales, and the diffusion coefficients which can be defined properly only in the long length and time scales. The central role in this is played by the memory effects. We also discuss the concept of diffusion under nonequilibrium conditions. In the third section, a variety of different theoretical approaches that have been employed in studying surface diffusion such as first principles calculations, transition state theory, the Langevin equation, Monte Carlo and molecular dynamics simulations, and path integral formalism are presented. These first three sections form an introduction to the field of surface diffusion. Section 4 contains subsections that discuss surface diffusion for various systems which have been investigated both experimentally and theoretically. The focus here is not so much on specific systems but rather on important issues concerning diffusion measurements or calculations. Examples include the influence of steps, diffusion in systems undergoing phase transitions, and the role of correlation and memory effects. Obviously, the choice of topics here reflects the interest and expertise of the authors and is by no means exhaustive. Nevertheless, these topics form a collection of issues that are under active investigation, with many important open questions remaining.


It is standard to use Mx2 and My2 to characterize the beam quality of a non-circular symmetrical beam on its x-axis and y-axis orientation. However, we knew that the values of Mx2 and My2 are inconsistent if one selects a different coordinate system or measures beam quality with different experimental conditionals, even when analyzing the same beam. To overcome this, a new beam quality characterization method, the M2 factor matrix, is developed. It not only contains the beam quality terms, Mx2 and My2, to characterize the beam quality along x-axis and y-axis orientation for the non-symmetric beam, but also introduces two additional cross terms, Mxy and Myx, which are used to characterize the location relationship between the principal axis of the test beam and coordinate system in experiment. Moreover, M2 factor matrix can be measured with a similar procedure to the traditional M2 factor whose measurement instructions are described in ISO11146 by adding some additional image and signal processing procedure. The measurement principle and method is present and the experiment system for beam quality M2 factor matrix is built to demonstrate the performance of M2 factor matrix with real experiments.


Duffing-Van der Pol equation with fifth nonlinear-restoring force and two external periodic forcing terms is investigated. By applying numerical simulations, including phase portraits, potential diagram, Poin  ́ care maps, bifurcation diagrams and maximal Lyapunov exponents, the nonlinear behavior and the complex dynamics of the system with two external periodic excitations are analyzed. At last, two kinds of methods are applied to control the chaotic behaviors of the system, effectively to a steady periodic orbit (or quasi-periodic orbit).


In the tales first told to her grandchildren, Sand manifests the versatility and genius of the genre (oral origins, suppleness of the moral) and specifically uses it to show that the fantastic of fairies and talking dogs is a metaphor for all that is marvellous in nature.


Stereotypes are widely held generalized beliefs about the behaviors and attributes possessed by individuals from certain social groups (e.g., race/ethnicity, sex, age, socioeconomic status, sexual orientation). They are often unchanging even in the face of contradicting information; however, they are fluid in the sense that stereotypic beliefs do not always come to mind or are expressed unless a situation activates the stereotype. Stereotypes generally serve as an underlying justification for prejudice, which is the accompanying feeling (typically negative) toward individuals from a certain social group (e.g., the elderly, Asians, transgender individuals). Many contemporary social issues are rooted in stereotypes and prejudice; thus research in this area has primarily focused on the antecedents and consequences of stereotype and prejudice as well as the ways to minimize the reliance on stereotypes when making social judgments.


We present the high time resolution observations of one of the Langmuir wave packets obtained in the source region of a solar type III radio burst. This wave packet satisfies the threshold condition of the supersonic modulational instability, as well as the criterion of a collapsing Langmuir soliton, i.e., the spatial scale derived from its peak intensity is less than that derived from its short time scale. The spectrum of t his wave packet contains an intense spectral peak at local electron plasma frequency, f(sub pe) and relatively weaker peaks at 2f(sub pe) and 3f(sub pe). We apply the wavelet based bispectral analysis technique on this wave packet and compute the bicoherence between its spectral components. It is found that the bicoherence exhibits two peaks at (approximately f(sub pe), approximately f(sub pe)) and (approximately f(sub pe) approximately 2f(sub pe)), which strongly suggest that the spectral peak at 2f(sub pe) probably corresponds to the second harmonic radio emission, generated as a result of the merging of antiparallel propagating Langmuir waves trapped in the collapsing Langmuir soliton, and, the spectral peak at 3f(sub pe) probably corresponds to the third harmonic radio emission, generated as a result of merging of a trapped Langmuir wave and a second harmonic electromagnetic wave.


The amounts of specific enzymes in animal tissues change in a variety of physiological states. Damage to the systems responsible for the synthesis of macromolecules may interfere with this form of metabolic adaptation.


Low-loss flexible polyimide waveguides have been fabricated and optoelectronic components have been successfully connected together using these waveguides. The waveguides were fabricated from commercially available polyamic acid and heat cured to form polyimide. Low bulk material absorption of the core polymer was measured in the 1300-1600 nm range. A processing technique which produced buried core waveguides removable from a silicon wafer was developed. Low (2 dB cm -1 ) fibre-to-fibre losses of flexible waveguides were measured. A novel optical wire bonding technique which removed flexible waveguides from a silicon wafer and connected them to optoelectronic chip facets was shown to be successful.


Summary With nanosecond scale at a 532 nm wavelength, we firstly measured the nonlinear optical absorption and refraction coefficients of Pd(po)2 complex by using Z-scan technique, here Hpo=1-hydioxy-2-pyridone. We describe an empirical expression for the case when nonlinear refraction is accompanied by nonlinear absorption to separately evaluate the nonlinear refraction and the nonlinear absorption by performing straightforward measurements with the aperture removed. The nonlinear optical response of Pd(po)2 was determined by the linear decreasing irradiance-dependence. The nonlinear absorption originates from the near resonant two-photon absorption while the mechanism of the nonlinear refraction is the near resonant two-photon absorption transition enhancement. The linear increasing dependences of the optical nonlinearities on the incident irradiance arise from the population redistribution due to the near resonant two-photon absorption.


polymer coating is the first coating simultaneously to provide barrier properties and to eliminate the closure as a source of siliconeoil-based subvisible particles (SbVPs). As a consequence of the coating's chemical composition and method of application, Omniflex Coated Plungers (OmniflexCP®) not only have barrier properties that result in superior chemical compatibility but have the added benefits of a significant reduction in SbVP levels and highly consistent delivery forces. OmniflexCP® continues to find broad applicability to address stability, compatibility, and performance challenges, in and beyond the world of biologics. THE EVOLVING NEEDS OF BIOLOGICS PACKAGING


Metrics for chemists are much argued, but the energy usage of a reaction has to be one of the most simple and effective methods of comparing technologies. In this concept paper, the energy consumed in preparing one mole of a chemical compound is compared for a variety of technologies. Data are gathered for traditional oil bath, supercritical CO2 (sc-CO2), and microwave reactors. Two different Suzuki couplings, a Knoevenagel condensation, and a Friedel−Crafts acylation are all compared in both the microwave and oil bath, as this is where the most noticeable differences were observed. The most notable result was an 85-fold reduction in energy demand on switching from oil bath to microwave reactor for a Suzuki reaction.


Notifiable Conditions Data Security and Confidentiality , The purpose of this policy is to provide guidance for NSW staff to manage the security and confidentiality of Notifiable Conditions data in any form, either unit records or aggregated form. This includes paper notification records, electronic notification records, the Notifiable Conditions Management System (NCIMS), the Secure Analytics for Population Health Research Intelligence (SAPHaRI), and/or any other form of data that has not been approved for release in the public domain.


We describe a new method for electron microscope image compression using the Discrete Wavelet Transform (DWT) method together with the Set Partitioning In Hierarchical Tree (SPIHT) algorithm. The conventional algorithm is enhanced with the List of Quantization Levels (LQL) algorithm. Our enhanced SPIHT algorithm successfully reduces the image file size to 1/8 to 1/32 times the size of the original image file. The quality of the decompressed images is very satisfactory.


Objective:To discuss in the diagnosis,differentional diagnosis and surgical treatment of fungal sinusitis.Methods: In 40 cases of fungal sinusitis diagnosed by pathology,their clinical manifestations,imaging characteristics and surgical efficacy was summarized and analyzed.Results:Of 40 cases of fungal sinusitis,32 were diagnosed by clinical manifestations and CT examination before surgery,8 by pathological examination after surgery.All cases performed nasal sinus debridement and postoperative irrigation with antifungal agents.All cases were cured.Conclusion: Fungal sinusitis has typical clinical manifestations,charactistic CT imaging.Surgery can debride focus and drain smoothly.Antifungal agents for irrigating nasal cavity is the key in treatment of fungal sinusitis.


A correction factor dependent upon frequency, type of phantom, and incident polarization, which should be applied to the measured specific absorption rate is proposed for homogeneous phantoms. It is shown for an application of occupational exposure in the neighborhood of a base station antenna that this correction factor not underestimates realistic exposure of workers. © 2007 Wiley Periodicals, Inc. Microwave Opt Technol Lett 49: 652–655, 2007; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.22249


The article is devoted to the formation of the communicative competence through the use of didactic games. Games needed for an elementary school, and they must be used in the system at different stages of the lesson, they include a variety of school activities, games used in the study of complex, hard-to-understand material. It is necessary to develop several sets of games on certain topics for a more systematic use them.


The head of the NHS in England has signalled that small local hospitals should become the focus of expanded and improved services in the community to allow elderly patients to be treated locally.

Simon Stevens, who took up the post of chief executive of the NHS in England in April, said that small hospitals were vital in meeting the needs of an ageing population and would provide focus for community services that had become "too complicated and too fragmented."

The current lack of coherent local services meant that too many patients were being denied "dignity and compassion," he said in an interview with the Daily Telegraph .1 Stevens said that countries such …


Knowing that a teacher education program's graduates affected P—12 student learning may be important, but knowing how the program prepared their graduates to affect learning is critical for ongoing reform efforts. In this essay, the author argues for the utility of looking at three sets of relationships involved in gauging the impact of teacher education programs on P—12 student learning—teacher education program impact on teacher candidate learning, teacher graduate practice of teacher education program outcomes in P—12 settings, and teacher graduate impact on P—12 pupil learning. The author also addresses three issues affecting the efficacy of reform efforts—a focus on proving versus improving, an absence of assessment literacy, and the need for teaching to support learning.


Usually, storage performance of data provenance is sustained through the use of compression algorithms. When provenance models with high repeatable rate and small variances are concerned, many current algorithms still face the challenge of avoiding redundancy. Adaptive Merge algorithm, featuring the optimisation of provenance factorisation, is introduced to compress provenance tree on the self-adaptive granularity basis. A kind of comprehensive solution regarding pointer-saving storage is provided here. The validity of Adaptive Merge algorithm is proven experimentally. Comparisons are made with Argument Factorisation to prove that our algorithm performs better in compression ratio. The extent of ratio enhancement depends on the features of data sets. The compression ratio of the provided provenance data set is increased by about 10%. Other data sets all show improvements in varying degrees. This suggests that by resolving pointer explosion issue, this new algorithm performs better and achieves a more reasonable compression ratio.


A novel approach to the development of continuously tunable laser source is presented. Laser output tunable over the spectal range from 300 to 500 nm is proposed to be obtained by SRS conversion of XeCl-laser wavelength in high pressure gas mixture with spectral overlapping of different Stokes lines. The efficiency of such a laser source can reach 1% within entire range of tuning whereas output energy can exceed 1J. The first experiments performed in this area are described.


The article covers the basics of education in Uzbekistan and France, the study of French in Uzbekistan, inter-university issues, scientific news, the dynamics of Uzbek requirements for education in France, public education and preschool education. perspective relations The analysis ofopinions and comments on the rise of relations in the field of education to a new era was carried out.IndexTerms:education, cooperation, French Alliance, dynamics, research, IFEAC, private sector, agreement, tourism, free education, staff exchange, intellectual potential, international experience in teaching


The design and testing of a low cost ultra low power microcontroller based zinc-air battery charge monitor is presented. The zinc-air battery chemistry is a lightweight and efficient portable energy solution that features an extremely flat voltage profile as the battery discharges. This design provides an alternative charge monitoring method to a voltage sampling system. The circuit operates by sampling the outgoing current and performing a count down algorithm. This design utilizes an ultra low loss resistive current sensor and a microcontroller to sample the outgoing current of a zinc-air battery in a fully programmable interval that defaults to two seconds. The circuit shuts down into a sleep mode when not sampling, which draws about 8/spl mu/A from the 12V battery. The average current is 22/spl mu/A. This current will discharge the battery by 1% in approximately 1.54 years. Overall cost is US$7.00 using bulk consumer parts. The paper presents design goals, considerations, and hardware results of the circuit.


An estimation of the dose relationship of intestinal iron absorption in man is only reasonable if a reliable method for the measurement of iron absorption is used, and the amount of available storage iron, which influences iron absorption considerably, is considered. Intestinal 59Fe2⊕-absorption was therefore quantitated by measuring the whole body retention of absorbed 59Fe within a 4 π-large volume radioactivity detector with liquid organic scintillator. The diagnostic 10 μΜοl (⧋ 0.558 mg) 59Fe2⊕-absorption test was used for discriminating between persons with normal 59Fe-absorption due to normal iron stores and persons with very much increased 59Fe-absorption caused by depleted iron stores. Within a dose range from 0.56 to 50 mg 59Fe2® the bilogarithmic plotting of the estimated 59Fe2⊕-absorption (in mg) against the iron dose resulted in a straight line, which can be described in males and females with normal iron stores by the equations Rmg = 0.206 · D0.676 and Rmg = 0.250-D0.668 respectively. In males and females with depleted iron stores the dose relationship can be characterized by the absorption equations Rmg=0.594·D0.684 and Rmg=0.731·D0.650 respectively. The whole body 59Fe turnover rate in man (= iron requirement) and the dose relationship of intestinal 59Fe-absorption are a suitable experimental basis for the oral iron prophylaxis and therapy.


The genomic DNAs of 14 accessions of mitao peach ( Amygdalus persica var. vulgaris ) were amplified by RAPD (randomly amplified polymorphic DNA) with 22 primers selected from 200 arbitrary 10 decamer primers.Phylogenetic relationship was analyzed through cluster of the bands in 180 amplified loci.The experimental accessions were divided into three groups.Molecular checking index and conservation of key germplasm which included 4 cultivars named Qiumi,Taiyuanshuimi,Shenzhouhongmi,Wenzhoushuimi were put forward according to the special bands.


Combining a differential form of the virial theorem with the Euler equation for the particle density, in a local density framework leads to a differential equation for the density, given the potential. This equation has the Thomas–Fermi density as a solution when the third derivative of the particle density is neglected. The arguments are restricted to one‐dimensional motion of independent Fermions.


Using a sample of bank failures over the period 2008-2010, we analyze the role of different types of regulatory capital in providing a buffer against failure risk. We report three key findings. First, we document that bank failure risk is negatively associated with Tier 1 capital, but positively associated with Tier 2 capital, which consists primarily of loan loss reserves. The results suggest that, contrary to the conventional notion of capital, a higher level of Tier 2 capital does not necessarily provide a buffer against deteriorating economic conditions. Second, the quality of Tier 2 capital is weaker (that is, its positive association with failure risk is higher) when banks report unusually large increases in loan loss reserves. Finally, the negative influence of unusually large loan loss reserves on the quality of Tier 2 capital is more pronounced for banks that are less constrained in adding back such reserves as Tier 2 capital, banks that have poorer audit quality and banks in which agency problems are more severe. Overall, our results suggest that Tier 2 capital is of low quality when banks use loan loss reserves to manage regulatory capital upwards.


Consider the second order neutral difference equation:Δ[a nΔ(x n+p nx g(n) )]+f(n,x σ(n) )=0,the sufficient conditions are established for the oscillation of the solutions of this equation.


Background: Intellectual disability is commonly associated with variety of etio-pathological and co-morbid conditions influencing outcome of rehabilitative measures. Understanding of these factors helps in better management of disabled condition. Methods: A qualitative retrospective case record review, of patients with intellectual disability, visiting psychiatry department of a tertiary care hospital, within a period of one year, was conducted to assess their epidemiological and clinical profile. Results: Patients with Intellectual disability are brought to the hospital at all ages and commonly by their parents. Etiologically related various peri-natal factors (delayed birth cry and seizures being most common) as well as childhood medical conditions (epilepsy and recurrent respiratory/GI infections being most common) were commonly found in these patients. Milestones are delayed in almost 60-70% of cases whereas various physical and psychiatric conditions commonly co-existed with disability. Conclusion: Clinical profile of these patients demands a comprehensive evaluation and management apart from routine IQ assessment.


Jitter elimination methods in common use on switch signal acquisition in observation and control system are summarized. Their shortcomings used in multiplex high-speed switch signal acquisition are proposed, and a kind of software arithmetic for jitters elimination based on probability statistics is put forward. This arithmetic, which has very high action sequence resolution and good anti-jamming performance, needn't hardware support, can be used on varied switch signal acquisition circuits.


Sustainable products and their marketing have played a crucial role in developing more sustainable consumption patterns and solutions for socio-ecological problems. They have been demonstrated to significantly decrease social consumption problems. Neuromarketing has recently gained considerable popularity and helped companies generate deeper insights into consumer behavior. It has provided new ways of conceptualizing consumer behavior and decision making. Thus, this research aims to investigate the factors influencing managers' decisions to adopt neuromarketing techniques in sustainable product marketing using the fuzzy analytic hierarchy process (AHP) approach. Symmetric triangular fuzzy numbers were used to indicate the relative strength of the elements in the hierarchy. Data were collected from the marketing managers of several companies who have experience with sustainable product marketing through online shopping platforms. The results revealed that the accuracy and bias of neuromarketing techniques have been the main critical factors for managers to select neuromarketing in their business for advertising and branding purposes. This research provides important results on the use of neuromarketing techniques for sustainable product marketing, as well as their limitations and implications, and it also presents useful information on the factors impacting business managers' decision making in adopting neuroscience techniques for sustainable product development and marketing.


Friday, April 12th, 1907. FILIGREE IMIPLANTATION.. MR. LAWRIE MCGAVIN referred to the difficulty experienced in attempting a cure in cases of very large or recurxent inguinal hernia. The success met with in dealing with very large abdominal hernia by Bartlett's method bad led him to modify it to meet the requirements of iinguinal hernia. For this purpose he utilized two separate filigrees, an iliac and a pubic section, of special pattern, without sacrifice of -testis or cord. The pubic section was placed upon the peritoneum between the internal abdominal ring and the pubes; the posterior wall of the inguinal canal was then remade over this by Bassini's method, the conjoined tendon being sutured to Poupart's ligament. The cord was then laid in position, and the 'transversalis and internal oblique muscles being incised outwards towards the iliac spine, the peritoneum was -peeled from their deep surface, and the iliac filigree so -placed on the peritoneum that its inner third lay upon the cord at its exit from the internal abdominal ring, overlap,ping for three-quarters of an inch the outer end of the pubic filigree. The divided muscles were then united over this iliac section, the aponeurosis of the external -oblique being closed over the whole area as far as the .external abdominal ring. The results in all cases hitherto had been entirely satisfactory. The method had produced an inguinal region so firm that no truss or support of any kind had been worn since operation, nor did it appear possible that any yielding of the scar could take place. No complication referable to the presence of the filigree had arisen, nor had any filigrees to be removed. Pain and discomfort were entirely absent. The author ciad adopted the method described as routine practice in all cases of recurrence or of very large hernia. Mr. W. G. SPENCER considered the suiggestion an -important advance in surgical technique. Bartlett's .method was of great value in the treatment of large umbilical herniae. He narrated a difficult case, in which eventually he had to remove the filigree, but not before it had made a mass of scar material which eventually closed the opening. Mr. DOUGILAs DREW had used filigree in cases of ventral *hernia. It was not necessary to remove the filigree, even if exudations occurred. The method was superior to that of -darning with silver wire, being much more quickly done. Mr. A. E. BARKER had had no experience with filigree, but thought it might be of great value in bad cases. The darning method had produced good results in his hands. Mr.McGAVIN, replying, said that he now used much larger filigrees, in fact, as big as 9 by 4 in. Recurrence was not probable, except when the filigree was too small.


When cooled, most liquids undergo a simple phase transition to an ordered crystalline solid, a relatively rigid substance that has a fixed shape and volume. In the phase diagrams for these liquids, there are no regions between the liquid and solid phases. Thousands of substances are known, however, that exhibit one or more phases intermediate between the liquid state, in which the molecules are free to tumble and move past one another, and the solid state, in which the molecules or ions are rigidly locked into place. In these intermediate phases, the molecules have an ordered arrangement and yet can still flow like a liquid. Hence they are called liquid crystals, and their unusual properties have found a wide range of commercial applications. They are used, for example, in the liquid crystal displays (LCDs) in digital watches, calculators, and computer and video displays.


Abbreviations Preface The Historical Contexts of Heidegger's 1920-21 Religion Courses Holger Zaborowski: A "Genuinely Religiously Orientated Personality". Martin Heidegger and the Religious and Theological Origins of his Philosophy Alfred Denker: Traces of Heidegger's Religious Struggle in his Phenomenology of Religious Life Istvan M. Feher: Religion, Theology and Philosophy on the Way to Being and Time: Heidegger, Dilthey and Early Christianity Franco Volpi: Heidegger and the Ascesis of Thought Jeffrey Andrew Barash: Theology and the Historicity of Faith in the Perspective of the Young Martin Heidegger Sylvain Camilleri: A Historical Note on Heidegger's Relationship to Ernst Troeltsch Phenomenological Method in the Early Heidegger Jean Greisch: Heidegger's Methodological Principles for Understanding Religious Phenomena Andrzej Wiercinski: Heidegger's Atheology: The Possibility of Unbelief S.J. McGrath: Formal Indication, Irony, and the Risk of Saying Nothing Reading Heidegger on Paul, Augustine, and Christian Mysticism Jaromir Brejdak: Philosophia Crucis: The Influence of Paul on Heidegger's Phenomenology Graeme Nicholson: The End of Time: Temporality in Paul's Letters to the Thessalonians Gerhard Ruff: Present History: Reflections on Martin Heidegger's Approach to Early Christianity Jennifer Anna Gosetti-Ferencei: The Poetics of World: Origins of Poetic Theory in Heidegger's Phenomenology of Religious Life Daniel Dahlstrom: Truth and Temptation: Confessions and Existential Analysis Costantino Esposito: Memory and Temptation: Heidegger Reads Book X of Augustine's Confessions Theodore Kisiel: Notes for a Work on the 'Phenomenology of Religious Life' (1916-19) Sylvain Camilleri: The Theological Architecture of the Religious Life-World according to Heidegger's Proto-Phenomenology of Religion (1916-1919) Dermot Moran: Choosing a Hero: Heidegger's Conception of Authentic Life in Relation to Early Christianity


Soybean is a commodity of great economic importance worldwide, particularly in Brazil, world's second largest producer. Nematodes, especially those of the Meloidogyne genus, severely limit productivity. Identification of nematode species is important for effective soybean management. Here, 26 populations of root-knot nematode (Meloidogyne spp.) from 15 municipalities in the states of Bahia, Mato Grosso, Goias, and Minas Gerais were characterized based on the morphology of the female perineal region, esterase profile, and identification based on amplification of specific regions of the population genome. Among the Meloidogyne spp. populations obtained, M. incognita and M. javanica, were identified. No mixed populations were present in the samples. Diagnosis based on molecular analysis was shown to be reliable and the fastest for characterization of nematode populations compared to other methods analyzed.


Global environmental issue related to state responsibility in protection and management of environment is consider by a develop and development state earlier. The new concept related to it is regulate environment right  in constitution. Green Constituion concept is on of solution for answering the concern by a people to environmental function degradation. Indonesia already regulate the environmental issues in constitution as  human  right. As a comparation study, a republic of Ecuador is one of the state famous as a first state which put the protection of environment in the constitution.Provision of protection and management of environment in Indonesia must regulate in clear in Indonesia Constitution, a lot of human activity cause the degradation and pollution that threat the human being and the next generation. The change of Indonesia Constituion is one of solution for praotection of environment in the future, so the law and other regulatin will be source to the constituion and oriented to the preservation of environment function.


A mental lexicon is a storage that holds the data about everything we know until it is required to be used. Onyms are stored in the mental lexicon in the form of concepts as individual units of knowledge which reflect the personal experience of the human being. The research aims to explore the standard ways of associative comprehension of proper names to better understand the essence and meanings they exhibit. The view substantiates that the transition from traditional to cognitive onomastic research will help to settle disputes among onomasticians and language philosophers as to the controversial subject of the semantic and referential status of proper names. In this research, the author conducts a free-associative experiment with 250 English native speakers. The result of the study was the conclusion that the ways of associative identification of onyms depend not only on our presuppositional knowledge, direct or indirect experience in connection to a certain proper name but also on a set of proprial and linguistic features peculiar to each name. The specificity of each proper name in this sense will determine the primary mechanism of its associative identification.


Appropriate to the nature of the data being swap over between the user and the server, the common changing of the user's name provides modest shield for the user's privacy. A more recent investigation of the mix-zone come near has been applied to road networks. They explore the required number of users to suit the unlink ability assets when there are repeated queries over an interval. This requires watchful control of how many users are limited within the mix-zone, which is complicated to accomplish in practice. The decisive goal of our protocol is to obtain a set (block) of POI records from the LS, which are secure to the user's position, lacking compromising the privacy of the user or the data stored at the server. We also carry in a safety replica and look at the security in the condition of our protocol.


Complex pulse evolutions, observed in a passively mode-locked continuous phase modulated ring dye laser, that are highly sensitive to the frequency chirping processes in the laser cavity are investigated. For particular values of intracavity group velocity dispersion, the pulse evolutions are periodic and reminiscent of soliton evolutions. A numerical model of the laser that successfully simulates the qualitative features of the real laser output temporally and spectrally is described. A careful investigation of the numerical model shows that, in the case of strong mode locking, the observed periodic pulse evolutions are not solitonlike, but result from a combination of frequency chirp and spectral walkoff. A distinct regime is identified where solitonlike pulse evolutions are sustained, and the transition between the two modes of operation is related to the strength of the mode locking. >


The invention relates to a charging connector for charging an electric vehicle, which is intended at a loading station (100) vorhaltbar for charging and which can be brought to charge a battery of an electric vehicle with a mating connector in electrical contact with a locking element (2), over the charging of the plug (1) is loading of the mating plug can be locked and can be unlocked by actuation, and with a securing element (3) with which the locking element (2) is blocked in its locked state. In this case, the locking element (2) is biased in its locked state and locked in its biased, the locked condition by the securing element (3).


Gypsophila paniculata L.seedlings production mainly method based on tissue culture,its production technology was attented by the researchers and industry staff.The techniques of Gypsophila paniculata tissue culture seedlings were depicted.The solutions were proposed to get rapid propagation seedlings.


From a functional perspective, scientific freedom prescribes maximum individual autonomy for each practitioner in selecting research subjects, communicating with colleagues, and validating or invalidating scientific findings. Extending knowledge and improving its soundness is possible in science, and to some degree in technology, to the extent that individual autonomy is unrestrained.b Science and technology, however, are not pursued in a social and political vacuum. Investigators of the mysteries of nature, from at least the dawn of Christianity to the eighteenth century, were well aware that their freedom to conduct research and report resulting discoveries was subject to limitation by the ecclesiastical and civil authorities of the day, as well as by the baser instincts of society. Fear of reprisal by the church, the state, or the mob was adequate incentive for initially cloaking scientific activities in secrecy. As historian Carl Becker has commented, however, much had changed by the dawn of the eighteenth century2'the moment in history when men experienced the first flush and freshness of the idea that man is master of his own fate."l Science and technology contributed significantly to this conviction. The workings of nature were but expressions of the will of God; to fathom the phenomena of nature was to reveal the beneficent intentions of the Almighty. The discovery of these truths through human reason and the accumulation of verifiable knowledge obviated the need to continue to rely upon official and dogmatic pronouncements of the church and the state.* Subsequently, however, as science and technology advanced, announcements about Holy revelations deriving from the analysis of nature were forsaken. In fact, as research results provided humankind with power over things, and even provided some human beings with power over other human


The Ekert 1991 quantum key distribution (QKD) protocol appears to be secure regardless of whatever devices legitimate users adopt for the protocol, as long as the devices give a result that violates Bell's inequality. However, this is not the case if they ignore nondetection events because Eve can make use of the detection loophole, as Larrson showed [Quantum Inf. Comput. 2, 434 (2002)]. We show that even when legitimate users take into account nondetection events Eve can successfully eavesdrop if the QKD system has been appropriately designed by the manufacturer. A loophole utilized here is that of 'free choice' (or 'real randomness'). Local QKD devices with a pseudorandom sequence generator installed in them can apparently violate Bell's inequality.


In accordance with the goals and the realized program provided under the proposed research project the predicted and expected results according to the phases of research were obtained. In this context, among the first that should be pointed out is the study of rare elements and elements from the group of the rare earth elements in individual polymetallic sites in Macedonia. Besides presenting them within the project report they were published as scientific papers, too. Then, we would give accent to the results from the newly studied areas as potential mining spots such as Kadiica, Ilovica and Kazandol. Here, we are mainly talking about the results obtained from geochemical research by primary and secondary halo of scattering, both in a standard laboratory test procedure and with the new field-laboratory method (NITON). As a final result geochemical maps of copper and associated elements in these sites were obtained. Also, special emphasis was given to the research of the rare and disseminated elements in coals from specific Neogene basins in Macedonia. It is completely new data in our region. Here we would like to stress that the certain studies within project regarding environmental issues were published in well known journals such as Environmetal Geochemistry and Health, and some others. Special attention was given to the study of the data from anthropogenic deposits and their ecological and specific economic importance. It must be noted that the data regarding the economic implications are respectable, since they are pioneers in such a form on the territory of our country. This was achieved also because of the strengthened bilateral cooperation between our two institutions.


Pharmaceutical cocrystals could be used to improve the physicochemical properties of active pharmaceutical ingredients. Here, a practical solid form screen approach to identify pharmaceutical cocrystals in the early development stage is proposed. This approach first used a cogrinding screen to identify potential cocrystal former leads that could form cocrystals with the compound of interest, followed by a solvent-based screen to identify, evaluate, and generate the cocrystal candidates. This approach not only allows fast identification of the cocrystal candidates but also provides insights on their scalability. Using this approach for the development drug candidate, a glutaric acid cocrystal was identified that provided an improved intrinsic dissolution rate in comparison to that of the free form, and therefore this cocrystal is potentially a better solid form for development. The effects of solvents and structures of cocrystal formers on the cocrystal formation and the rationales for this approach are al...


Abstract:  Despite advances in the quality of participatory decision making for conservation, many current efforts still suffer from an inability to bridge the gap between science and policy. Judgment and decision‐making research suggests this gap may result from a person's reliance on affect‐based shortcuts in complex decision contexts. I examined the results from 3 experiments that demonstrate how affect (i.e., the instantaneous reaction one has to a stimulus) influences individual judgments in these contexts and identified techniques from the decision‐aiding literature that help encourage a balance between affect‐based emotion and cognition in complex decision processes. In the first study, subjects displayed a lack of focus on their stated conservation objectives and made decisions that reflected their initial affective impressions. Value‐focused approaches may help individuals incorporate all the decision‐relevant objectives by making the technical and value‐based objectives more salient. In the second study, subjects displayed a lack of focus on statistical risk and again made affect‐based decisions. Trade‐off techniques may help individuals incorporate relevant technical data, even when it conflicts with their initial affective impressions or other value‐based objectives. In the third study, subjects displayed a lack of trust in decision‐making authorities when the decision involved a negatively affect‐rich outcome (i.e., a loss). Identifying shared salient values and increasing procedural fairness may help build social trust in both decision‐making authorities and the decision process.


The article discusses the formation and development of civil society throughout the evolution of the development of mankind. Identifies five stages and given them feature. Attention is drawn to the new qualitatively different stage of formation of the electronic civil society in the conditions of modern globalization world. Proved position of the two models of interaction between civil society and public authorities in view of the world political practice of cooperation and confrontation. Formation and development of civil society is a continuous process. Activation of its institutions depends on the interests, both by their leaders and political elite of the state, interested in forming a positive image among the various actors of the world political process. Attention was focused on the activities of civil society in different historical periods and political regimes.


The granddaughter of the writer Sophie von La Roche, the sister of the poet Clemens Brentano, And above all the wife of Achim von Arnim must truly have been difficult to comprehend. Born in Frankfurt am Main in April of 1785, she confronted her contemporaries as a sensitive Poet, a socially and politically engaged writer, caring mother of seven children, a dedicated wife And an enthusiastic friend. Among these contemporaries was Goethe as well: Together with her husband Achim von Arnim and her brother Clemens, Goethe brought practically cult status to the Weimar Poet-Princess to the point where he felt besieged by the "Tollhausler" (bedlam people) and expelled her from his house. Bettina dedicated her first book to the idolized Weimar master: "Goethes Briefwechsel mit einem Kinde" (Goethe's Correspondence with a Child), published in 1835.


28 Endothelial nitric oxide synthase (eNOS) is the predominant isoform that generates nitric oxide 29 (NO) in the blood vessels. Many different regulators govern eNOS function, including heat 30 shock protein 90 (Hsp90). Hsp90-dependent phosphorylation of eNOS is a critical event that 31 determines eNOS activity. In our earlier study, we demonstrated the occurrence of an Hsp9032 inhibitor kappa B kinase beta (IKKβ) interaction under high glucose environment. In the present 33 study, we have further defined the putative binding domain of IKKβ on Hsp90. Interestingly, 34 IKK binds to the middle domain of Hsp90, which has been shown to interact with eNOS to 35 stimulate its activity. This new finding suggests that there is a tighter regulation of eNOS activity 36 than previously assumed. Furthermore, addition of purified recombinant IKKβ to the eNOS37 Hsp90 complex reduces the eNOS-Hsp90 interaction and eNOS activity, indicating the existence 38 of a competition for Hsp90 between eNOS and IKKβ. The physiopathological relevance of the 39 IKKβ-Hsp90 interaction has also been demonstrated using in vitro vascular endothelial growth 40 factor-mediated signaling and Ins2 Akita in vivo model. Our study further defines the preferential 41 involvement of alpha vs beta isoforms of Hsp-90 in the eNOS-Hsp90-IKKβ interaction even 42 though both Hsp90α and β stimulate NO production. These studies not only reinforce the 43 significance of maintaining a homeostatic balance of eNOS and IKKβ within the cell system that 44 regulates NO production, but also confirms that the interaction between IKKβ and Hsp90 is 45 favored by high glucose leading to the impairment of the eNOS-Hsp90 interaction thus 46 contributing to endothelial dysfunction and vascular complications in diabetes. 47


The present study investigates the possibility of using a stand-alone solar/micro hydro hybrid power system for low-cost electricity production which can satisfy the energy load requirements of a typical remote and isolated rural area. In this context, the optimal dimensions to improve the technical and economical performances of the hybrid system are determined according to the load energy requirements, the solar and water resources and the importance of supply continuity. The proposed system's installation and operating costs are simulated using the Hybrid Optimization Model for Electric Renewable (HOMER) with the stream flow, the solar radiation and the system components costs as inputs; and then compared with those of other supply options such as grid extension and diesel generation.


Mercury (Hg) can cause acute and chronic intoxications in humans, such as damage to the central nervous system, lungs, and kidneys. Goldsmiths pose the risk of exposure to Hg through direct skin contact or inhalation of Hg vapor during the amalgam burning process. This study aims to assess the level of workers' knowledge regarding the risk of exposure to Hg and investigate the practice of preventing health risks from exposure to Hg in household-level gold-crafting activities. The study used a descriptive observational approach. The population of the study was 110 gold craftsmen in the Rapokkaling Village, Makassar City. The number of samples was 52 people determined by the purposive sampling technique. The data collection instruments included a structured questionnaire, camera, recorder, and field note. The results of the data analysis showed that the proportion of respondents with a sufficient level of knowledge was greater than that with a low level of knowledge (65.4% and 34.6%, respectively). On the other hand, the results of the observation showed that 100% of gold craft workers had unsecure work practices. Sufficient knowledge about the risks of exposure to Hg does not guarantee the discipline of implementing secure work practices including using personal protective equipment.


A numerical comparison of the Lorenz and Charney–Phillips vertical grids for capturing the steady state of a set of equations that models the large‐scale dynamics of the atmosphere and the planetary boundary layer (Part I of this article) has revealed important differences between the grids. Due to suppression of a negative feedback, Charney–Phillips grids that involve averaging of shear in the boundary‐layer terms are not able to capture the structure of the boundary layer accurately. The Lorenz grid performs well in terms of capturing the boundary layer on its own, but the Charney–Phillips grids that use averaging of potential temperature gradient are generally preferred once dynamics are included. Any finite‐difference approximation of the problem must be capable of accurately representing both the steady‐state and time‐dependent parts of the solution. In this Part II of the article, the ability of the Lorenz and Charney–Phillips configurations to capture the transient part of the system is considered. The configurations are compared in terms of their ability to capture the eigenmodes of the solution. Full comparison between Lorenz and Charney–Phillips grids is limited by non‐normality of the linearised system, associated with the boundary layer. The Lorenz grid computational mode is examined. The structure is modified by the boundary layer but it still exists. For the modes that could be accurately examined, it is found that both grids perform well in terms of capturing spatial and temporal mode structure. Some Lorenz grid modes are identified that have spurious computational mode‐like behaviour occurring near the top of the boundary layer. Copyright © 2012 Royal Meteorological Society


The after body of RORO ship or car ferry is characterized as follows; the frame line under water plane is very fine in order to improve the performance of propulsion, but the frame line upper water plane is very fat so as to take the broader deck area. Therefore the sectional form near the water plane becomes flat, and the angle between the water plane and the transverse section of ship is smaller than the other ship. These ship may suffer from the wave impact pressure on the stern flare. For this reason, the experimental and analytical studies on the stern flare impact pressure were carried out, and following results were obtained.(1) The fairly good agreement was found between the impact pressure coefficients obtained from the experiment in regular waves with those by Wagner's method. The magnitude of the coefficient was about 1020.(2) The maximum impact pressure which was predicted in irregular head waves from 3 to 11 Beaufort wind scale was about 2030 t/m2 for actual ship. This magnitude is smaller than the bow flare impact pressure, but the probability of occurrence of impact pressure is large. So it seems to be probable that the noise and fatigue due to transient vibration induced by the impact force becomes a problem.


PURPOSE: To produce Na 2 SiO 3 excellent in handleability and having a high bulk density by treating powdery amorphous Na 2 SiO 3 obtained by spray-drying water glass solution by using hot air by flue gas inside a rotary tubular kiln and mechanically pulverizing the amorphous Na 2 SiO 3 discharged from the kiln. CONSTITUTION: The water glass solution manufactured under prescribed conditions is treated with the hot air at 200-300°C in a spray-drying zone for the residence time of 10-25 seconds and at the temperature of waste gas leaving the zone of 90-130°C. Thus, the powdery amorphous Na 2 SiO 3 having the water content of 15-23 wt.% and the bulk density of ≥300 g/l is obtained. Then, the Na 2 SiO 3 is introduced to an obliquely arranged rotary tubular kiln and processed with the flue gas in countercurrent at the temperature of 250-500°C. Then, the amorphous Na 2 SiO 3 discharged from the kiln is pulverized into the grain size of 0.1-12 mm by using a mechanical pulverizer to obtain the objective amorphous Na 2 SiO 3 . COPYRIGHT: (C)1991,JPO


In order to study unified modeling of variable constraints system,a dynamics equation of stance phase for jumping robot was established based on floated-basis space.The take-off posture and load matching index of jumping robot were optimized by applying inertia matching manipulability and directional manipulability.The center of gravity trajectory of the jumping motion was planned by a 5th order polynomial function taking into account the constraint conditions of velocity and acceleration.The numerical simulation and experimental results show the inertia matching is direct proportional to the robot's jumping height,and it is a valid method to motion optimization.


For the aim of improving motor running efficiency and reducing early fault loss,a fault diagnosis model based on integrated neural network is proposed.The signal of stator current and rotor oscillation are as input signal of diagnose distinction.It identifies fault with improved BP neural network,and applies two diagnosis sub-networks to diagnose local faults.The final conclusion is obtained through fusing the diagnose result of different sub-network.It increases the fault diagnosis accuracy.The simulation results show that the diagnosis method,as a higher accuracy and quicker diagnosis,is a more practical fault diagnosis method.It has important practical significance for motor fault monitoring and forecasting.


Ground applications of 3 candidate insecticides were tested to determine their effectiveness in reducing grasshopper densities north of Lame Deer, MT during the summer of 1981. All tests were conducted on moderately infested (9.0-13.7 grasshoppers/sq yd), relatively flat rangeland. Each materia was applied in 8 fluid oz of water per acre in 30-foot swaths using a modified John Blue Low Volume Sprayer (John Blue Company, Huntsville, AL; mounted on a ¾ ton 4-wheel-drive truck. Each candidate was compared to a standard ULV treatment of 8 fluid oz of 95% technical malathion per acre, and to an untreated. The species listed above comprised 74, 19, 2, and 2% of the grasshopper infestation, respectively, with 35.1% being adults. Three other species each comprised less than 1% of the infestation. Mortality was determined at 1,3, and 7 days posttreatment by counting with a pointer the number of grasshoppers in 50 estimated one-sq-yd quadrats for 10-acre plots, or 25 estimated one-sq-yd quadrats for 2.5-acrt plots. The experimental design for cyfluthrin was 10-acre square plots of 3 rates replicated 4 times in a randomized complete block design. The highest dosage crystallized in a mixing container during application, so data for that dosage were obtained from only 2 replicates. In a separate test the experimental design for isofenfos and flucythrinate was 2.5-acre square plots of 2 rates and, replicated 2 times.


Spatiotemporal distributions of CO2 obtained from the greenhouse gases observing satellite (GOSAT) over China from 2010 to 2017 and influence factors are presented in this study. It shows an annual increase and a seasonal cycle. The CO2 annual growth rate was about 2.34 ppm year−1, with the highest value being in spring and the lowest in autumn. Yearly variations in the CO2 over eight economic regions are prominent, the regions with higher CO2 concentration also have higher increase rate. Some factors affecting variations in CO2 are analysed in this study. There is a stronger negative relationship between CO2 and MODIS vegetation products. Population density and energy consumption are anthropogenic factors in increasing CO2 concentration, and CO2 variation shows a high correlation with population density in eight economic regions [coefficient of determination (R2) = 0.76]. CO2 and energy consumption also have a better correlation (R2 > 0.66) in the most regions.


Integration of many functions in mobile devices often results in the insufficiency of computing resources and security problems. We utilize multiple computing modules distributed in the environment as external resources, and call this processor network system "UMP (Ubiquitous Multi Processor) system." In our previous research, the basic architecture of a UMP system and its communication theory were verified. This paper evaluates the correlation between data granularity and system performance for applications with variable data granularity and verifies the usefulness of these parameters in dynamic scheduling necessary to construct intelligent systems. A JPEG encoding application was evaluated on the UMP system with six sub-functional modules. Optimization of data granularity shows 180% improvement of system performance. The experimental result shows that data granularity of inter-PE communication could be an important parameter in optimizing the system architecture and dynamic scheduling. Moreover, the result shows the possibility of further performance improvement through optimization of data granularity by focusing on individual modules.


OBJECTIVE To identify if Trichosporon asahii exist cph1 gene homolog of Candida albicans,and analyze its nucleotide sequence.METHODS Nuclear DNA was extracted from the cells of T.asahii by using a simplified protocol,designed 29 pairs of primers according to the cph1 gene sequence of C.albicans and amplify by PCR.The PCR products were cloned and sequenced using the ABI377 nucleotide sequenator,and BLAST analysis.RESULTS An 827 bp gene was amplified successfully,which was homolog with the cph1 gene of C.albicans and their identity was 97.3%.CONCLUSIONS This trial determines the clone cph1 gene in T.asahii for the first time,which makes bases for the role of cph1 gene in the hypha formation.


The purpose of this document is to present, step by step, the entire production process of the theme "Despertar entre Girasoles" by the author and composer Mafer Tapia, in which all the technical and practical points for which they had to pass are detailed. Applying the knowledge learned throughout the career, we proceed with the pre-production stage, where the theme was carefully analyzed applying the necessary changes that will serve to improve the proposal to work; proceeding with the production stage, the recordings were made with due care to maintain the feeling of each instrument to generate the desired sound and already established from the beginning by its composer and producer; In the post-production stage, editing and mixing played an important role since having resources and audios ready, what was done was to find the best way for the whole orchestration to sound well assembled containing the essence of popular music Latin American. The choice of the design and the discographic art of the theme was a work in conjunction with the artist and the graphic designer, to capture and stamp in a graphic way, the concept and the interpretation that the artist makes of the theme.


The electromagnetic characteristics of a Koch fractal antenna as an element and as an array are extensively examined. The method of moments is used to analyze the antenna structure. The characteristics of the Koch fractal monopole antenna on portable radio equipment are investigated. The use of the Koch fractal monopole can reduce the length of the antenna, decrease the current flowing along the body of the handset and improve the impedance matching to the feed line of the antenna. A Koch fractal antenna is presented for generating circularly polarized radiation pattern. The scattering properties of the Koch fractal elements are calculated. The backscattering wave from one element and an array is investigated.


This book is a contribution to the discussion of a constitutional reform of the United Nations, a discussion rekindled by the end of the Cold War and the significant involvement of the UN in international peacemaking and peacekeeping since the Kuwait crisis. Like the new debate, the work focuses on the Security
Council, its composition and possible enlargement, its decision-making process and competences, and its relationship with the General Assembly and the International Court of Justice. Particular regard is given to the right of veto of the permanent members of the Security Council, which is seen as the central, and most problematic, feature of the present constitution of the UN. The work describes and analyzes the reform discussion as it has taken place at the UN since 1991. The different proposals made by governments, NGOs and individual scholars are evaluated by applying a number of standards and concepts ensuing from a perception of the UN Charter as constitution of the international community. Thus, the study advances a comprehensive constitutional theory of the UN and redefines the place of the Charter in contemporary international law. Its author was awarded a prize by the Faculty of Law of Humboldt University for having submitted the best dissertation in law in 1997-98.


The process of globalization has been a controversial topic so far, and it is considered as capitalist globalization, because globalization is driven by capital and takes transnational corporation that pursues benefits as the carrier. Although this topic is a bit old, globalization has always influenced people's life. Today, anti-globalization is also a rash issue, and those who support this view believe that globalization has increased inequality between countries. This paper uses critical thinking and a fair perspective to analyze globalization, putting forward an idea that globalization will promote the process of democracy globally. Simultaneously, globalization provides new ideas for global collaboration and even the establishment of global democratic government. The methodology of this paper is theoretical analysis, basing on literature review. Obviously, globalization is a double-edged sword. It not only benefits wealthy countries, but also improves the strength of developing countries, but the negative effective of globalization needs to be paid attention to. Globalization is the only way for the development of human society and the engine that promotes the growth of the world economy, meaning that the historical trend is irreversible and will continue to move forward. Therefore, the approach used by developing countries should be to take measures to minimize its negative impact, rather than to resist it.


The main objective of suspension system is to reduce the motions of the vehicle body with respect to road disturbances. The conventional suspension systems in road vehicles use passive elements such as springs and dampers to suppress the vibrations induced by the irregularities in the road. But these conventional suspension systems can suppress vibrations to a certain limit. This paper presents a novel idea to improve the ride quality of roads vehicles without compromising vehicle's stability. The paper proposes the use of primary and secondary suspension to suppress the vibrations more effectively.


Perlecan is a large heparan sulfate proteoglycan with a wide tissue distribution and multiple potential functions (see [Iozzo 1998][1]). The glycosaminoglycan chains, located in the NH2-terminal domain of the core protein, bind basic FGF-2 and have been shown to promote the mitogenic and angiogenic


A referral can be defined as a process in which a doctor or hospital does not possess sufficient resources (drugs, equipment, skills) to manage a clinical condition and it seeks for the assistance of a better or differently resourced facility at the same or higher level to assist the patient or take over the management of, the clients case, which is not possible for the first hospital or doctor


As an effort to prevent the incidence of non-communicable diseases and maintain the health status of the Indonesian population, the Indonesian government created the Integrated Non-Communicable Disease Development Post program (Directorate General of Disease Control and Environmental Health, 2014). In general, the purpose of this study was to analyze the differences in consumption of vegetables and fruit between male and female farmers in Jenggawah sub-district, Jember district. This research can be used as a source of information regarding the consumption of vegetables and fruit among farmers and the differences when viewed by gender. The research design used was comparative quantitative with a retrospective approach using secondary data. In this study, an analysis of the difference in consumption of vegetables and fruit was carried out on male and female farmers. This study analyzes secondary data from performance reports on the implementation of PTM Posbindu in the work area of the Jenggawah Health Center in 2021, namely February-June and August-October. Based on the results of the research discussed in this study, it was found that there were differences in the consumption of vegetables and fruit between male farmers and female farmers at the PTM Posbindu Puskesmas Jenggawah. The majority of male farmers were identified as having poor eating behavior on the type of fiber per day which men should have the behavior of eating at least 37 grams of fiber per day based on the nutritional adequacy rate table. And the majority of female farmers (69%) were identified as having good eating behavior, namely 30g of fiber per day which was in accordance with the nutritional adequacy rate table.


ABSTRACT When communicating product-related information to consumers, companies must often choose among different media types. Understanding how consumers seek media as their source of information when making purchase decisions is highly important for marketers to optimize their media-selection decisions and achieve maximum communication results. However, an extensive review of the literature indicates that little is known about the advertising media preferences of consumers of technology-based services. This research examines the media preferences of mobile phone service consumers in the United States as their source of information regarding competing mobile phone service plans. The study also addresses whether the advertising media preferences of mobile phone service consumers vary across demographic characteristics. The survey data were collected from 471 employees and students of two higher education institutions. Descriptive statistics including medians and quartiles are calculated for media preferences. Frequencies are used to summarize demographic characteristics. Chi-square tests are used to determine if relationships exist between demographic characteristics and advertising media preferences. The results indicate that for mobile phone service buyers in the United States, the most important media they consider as their source of information on competing mobile phone service plans is word of mouth. Moreover, consumers ranked provider's website as second, search engine marketing as third, and social media as the fourth preferred source of information for competing mobile phone service plans. Also, the research results reveal that media preference as a source of information on competing mobile phone service plans differs by respondent age, but not by gender. The implications of the research findings on theory and practice are discussed.


The research reported in this paper is part of an ongoing project on promoting Aboriginal cultural storytelling using mobile participatory mapping applications and web‐based interactive storymaps. This paper presents a conceptual framework for developing a co‐designed participatory storymap. The storymap aims to ubiquitously collect location‐based knowledge and stories in both online and offline modes, as well as present an interactive web map that dynamically integrates information recorded as georeferenced texts, images, audios, and videos. The participatory mapping has a potential to allow Aboriginal communities to capture and preserve their cultural heritage on their own using a smartphone or tablet. Ethical co‐designing process of implementing the storymaps is also discussed.


Two modes of flexural waves can be generated by a dipole source in an anisotropic borehole. Their velocities are related to those of the fast and slow shear waves in the formation. The particle motions and the polarization diagrams of the fast and slow flexural waves are measured in a borehole model made of phenolite material with transverse isotropy or orthorhombic anisotropy. The experimental results show that the particle motion of the fast Aexural wave is linear and is in the same direction as that of the fast shear wave in the formation. The polarization direction of the fast flexural wave coincides with that of the fast shear wave and is independent of the direction of the dipole source. The particle motion of the slow flexural wave is nonlinear and elliptic. Its polarization direction and the variation are dependent on the anisotropic material and the source direction. This means that the slow flexural wave is a more complicated wave mode rather than the simple mode where the particle motion generated by a dipole source is in the direction of the slow shear wave. The polarization characteristics of the fast flexural wave can be applied to determine the principal axis of an anisotropic formation by in-line and cross-line logging data.


This paper investigates the utilization of the complex chaotic dynamics given by the several selected timecontinuous chaotic systems, as the chaotic pseudo random number generators and driving maps for the chaotic optimization. Chaos based optimization concept is utilizing direct output iterations of chaotic system transferred into the required numerical range or it uses the chaotic dynamics for mapping the search space mostly within the local search techniques. This paper shows two groups of complex chaotic dynamics given by either chaotic flows or oscillators. Simulations of examples of chaotic dynamics transferred to the pseudo random number generators were performed and related issues like distributions of such a systems, periodicity, and dependency on sampling times are briefly discussed in this paper.


Play better golf, whatever your level. From tee shots and iron play to pitching, chipping and coping with bunkers, find out how to play golf with expert tuition and easy-to-follow photographic sequences. Improve your game with illustrated tests and drills that highlight key technical points. Discover how to fix the 10 most common faults that can creep into your playing, then check your progress with performance charts. Learn about every aspect of golf from buying equipment to rules, etiquette and golfing terms. It's your fast-track to a better game.


The authors examine performance changes after two leveraged buyouts (LBOs) in the hospital industry, one an employee stock ownership plan (ESOP) and the other a managed buyout (MBO). The findings show that hospitals owned by HCA, the MBO firm, and Health Trust, the ESOP firm, did not increase revenues, decrease operating expenses, or improve profitability after the LBOs, relative to other hospitals in their local markets. Nor were the numbers or salaries of employees at these facilities decreased. Although performance incentives associated with LBOs did not change performance at the hospital level, incentives to meet debt payments did result in corporate changes. More specifically, the LBOs led to corporate downsizing through the sale of hospitals and subsidiaries.


The bronchial asthma (asthma) is a chronic inflammatory airway disease characterized by celelular component and infiltration into the airway submucosa of cells, which contain eosinophils,labrocytes,lymphocytes, neutrophils and epitheliums. Asthma is result from the contribution of genetically susceptible individuals and the various environmental stimuli. Studies have examined the contribution of toll-like receptors (TLR) and immunocells to the development of asthma. Through identifying the various micro-organisms,TLR may be involved in mechanisms provoking Thl-or Th2-biased immune responses and may, therefore, be an important factor in either preventing or promoting asthma. This review will explore the relation between TLR and asthma,provide a new idea of therapeutic effect to asthma.

Key words:
Toll like receptor ; Immunocell ; Bronchial asthma


Annotation Relevance of the study is due to the importance of composition and maturity of the dispersed organic matter (DOM) as indicators of rock forming conditions, which may contribute to the paleoecological reconstruction of sedimentation conditions for rocks in the ore-bearing stratum of the Safyanovskoe deposit. Objective: to analyze the composition and characteristics of DOM in carbon-siliceous rocks of the ore-bearing stratum of the Safyanovsky copper-pyrite deposit. The obtained characteristics of the DOM make it possible to reveal the source of original accumulation and the level of its transformation under the influence of various geological processes. Methods. A detailed study of DOM was carried out by the EPR method (electron paramagnetic resonance) for powder preparations. EPR spectra were recorded at room temperature on X-band spectrometers DX-70, ESR 70-03 DX/2, and SE/X-2547 RadioPAN. The analytical procedure for studying organic matter (OM) included: determination of insoluble residue and Corg content in the rock, extraction of the chloroform bitumoids (CB) and the alcohol-benzol bitumoids (ABB), humic acids (HA), determining the group composition of CB and hydrocarbons (HC), chromatographic fractionation with determination of the sum of methane-naphthenic and aromatic fractions of hydrocarbons, GC-MS analysis of n-alkanes, cyclic and polyaromatic hydrocarbons (PAHs). GC-MS analysis was performed on the complex Hewlett Packard 6850/5973 with a quadrupole mass detector and analytical information processing software. Results. Analysis of the EPR spectra of carbon-siliceous rocks of the Safyanovskoe deposit showed the presence of the two types of carbon signal (C-org), characteristic of the plant and the animal residues. It was also found that the DOM has never been exposed to temperatures greater than 300 °C. Geochemical analysis of OM indicates that DOM is at a high maturation stage (residual organic matter (ROM) > 99%). But the type of distribution of polyaromatic hydrocarbons (PAHs) suggests that the primary OM was specifically altered at elevated temperatures. Conclusions. DOM of carbon-siliceous rocks of the Safyanovsky deposit is genetically the same, its type is mainly sapropelic and accumulation is associated with marine conditions. A characteristic feature is, on the one hand, its high polymerization, which is typical for DOM of the stage of late mesocatagenesis, and, on the other hand, its molecular composition does not allow us to talk about the maturation of DOM in the process of natural regional metamorphism.


The Layer-wise Relevance Propagation (LRP) algorithm explains a classifier's prediction specific to a given data point by attributing relevance scores to important components of the input by using ...


Human papillomavirus (HPV) type 16 infection is one of the most important etiological agents of oropharyngeal squamous cell carcinoma. Patients with HPV-positive squamous cell carcinomas of the head and neck were reported to have a better clinical outcome than patients with HPV-negative tumors. Because HPV16 E6 and E7 oncoproteins are highly immunogenic and constitutively expressed within the tumor cells, HPV-specific T cell immunity may contribute to the better prognosis of HPV-positive tumors. We analyzed the frequency, phenotype and function of HPV16 E6/E7-specific tumor-infiltrating T cells (TILs) in oropharyngeal tumors and tested the effect of anti-PD1 mAb (nivolumab), soluble Tim-3 (sTim-3) and homeostatic in vitro expansion on these characteristics. We show that 73.1% of HPV-associated oropharyngeal tumors are positive for HPV16-specific T cells capable of producing IFNγ upon stimulation with E6/E7 peptide pools. These IFNγ-producing HPV-specific TILs were mainly PD-1+Tim-3-CD8+ T cells, identifying Tim-3 rather than PD-1 as a marker of T cell dysfunction. Consequently, specific IFNγ production was further enhanced by combined nivolumab plus sTim-3 treatment, but not with nivolumab alone. Our data provide the rationale for exploring additional setups of anti-PD-1 mAb treatment, including combinations with other check-point blockers, such as Tim-3 and/or with HPV16-directed therapeutic vaccines. Citation Format: Simona Partlova, Kamila Hladikova, Vladimir Koucky, Anna Fialova, Radek Spisek, Jan Boucek, Michal Zabrodsky, Michael Halaska, Ruth Tachezy, Marek Grega, Jean-Francois Fonteneau. Dysfunction of HPV16-specific CD8+ T cells derived from oropharyngeal tumors is related to the expression of Tim-3 but not PD-1 [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 1002.