................................................................................................................ VII 1. REVIEW OF THE LITERATURE ...................................................................... 1 1.1 THE CCC FAMILY AND KCC2 ........................................................................... 1 1.2 THE KCC2 GENE ................................................................................................. 2 1.2.1 Gene structure .................................................................................................. 2 1.2.2 mRNA expression pattern ................................................................................ 5 1.2.3 Regulation of gene expression ......................................................................... 6 1.3 KCC2 PROTEIN ISOFORMS .............................................................................. 9 1.3.1 Structure and interactions ................................................................................ 9 1.3.2 Protein expression .......................................................................................... 13 1.3.3 Subcellular localization ................................................................................. 14 1.3.4 Functional roles of KCC2 isoforms ............................................................... 15 1.4 THE WNK–SPAK/OSR1 PATHWAY ..................................................................... 18 2. AIMS OF THIS STUDY ...................................................................................... 21 3. MATERIALS AND METHODS ......................................................................... 22 3.1 PRIMARY ANTIBODIES .......................................................................................... 23 4. RESULTS AND DISCUSSION........................................................................... 26 4.1 REGULATION OF KCC2B EXPRESSION BY USF PROTEINS ..................... 26 4.2 CELLULAR EXPRESSION PATTERN ............................................................ 32 4.2.1 Telencephalon ................................................................................................ 32 4.2.2 Diencephalon ................................................................................................. 33 4.2.3 Brainstem ....................................................................................................... 34 4.2.4 Cerebellum ..................................................................................................... 35 4.2.5 Spinal cord ..................................................................................................... 39 4.3 SUBCELLULAR LOCALIZATION ................................................................... 39 4.3.1 Different surface expression .......................................................................... 39 4.3.2 Different subcellular targeting ....................................................................... 42 4.4 FUNCTION AND REGULATION ................................................................... 44 4.4.1 KCC2a functionality ...................................................................................... 44 4.4.2 Regulation by SPAK ...................................................................................... 46 5. CONCLUSIONS AND OPEN QUESTIONS ..................................................... 49 6. ACKNOWLEDGEMENTS ................................................................................. 56 7. REFERENCES ..................................................................................................... 57


A R T I C L E I N F O A B S T R A C T Article history: Received: .18 May, 2020 Accepted: 17 July, 2020 Online: 19 August, 2020 The integration of renewable energy distributed generation (REDG) into the energized distribution power grid has become more popular in recent years. This has been escalated by the general global energy shortages. The REDG has proven to be effective for energy sustainability and reliability. However, there are technical challenges which arise from integrating REDG into the energized power grid. These challenges include the effectiveness of power grid protection against faults. In this paper, a fault diagnostic algorithm is proposed to detect faults in a power system integrated with REDGs. The algorithm utilizes wavelet packet transform (WPT) for signal filtering, support vector machine (SVM) for fault classification and detection. The proposed algorithm is validated using the Eskom 90 bus electrical system and the results obtained show that faults can be detected with a high accuracy of 99%. The Eskom 90 bus system is modelled using DigSilent platform and the algorithm is tested on the WEKA software.


Coating thickness distribution, surface appearance, and grain size are known to be important factors in determining the effectiveness of coatings used in the production of printed circuit boards. Square wave unipolar pulse and bipolar pulse reverse current electroplating of copper using an acid copper electrolyte has been reported to provide a coating superior to that produced by dc under certain pulsing conditions. The present paper describes a systematic assessment of the properties of electrodeposited coatings produced under unipolar pulse and bipolar pulse reverse current plating conditions. Results show that the overall coating uniformity under pulsing conditions is better than that obtained using dc plating. The surface texture of the coatings is shown to be strongly dependent on the pulsing conditions and is especially affected by bipolar pulse reverse conditions.


In the prologue "The Contrary Assumption," the author – a mathematical social scientist – provides a background to the book, his work, and research and how he has been talking to people for over a decade about diversity bonuses. The premise is that in the West, most businesses are now in the knowledge economy, making teams diverse, producing bonuses, i.e. quicker or better results, as opposed to teams that are homogenous. The author clarifies that his idea of diversity is not always based on gender, race, religion, etc., but on cognitive diversity.


Dental traumatic injuries occur frequently in children. The close relationship between the apices of primary teeth and germ of the permanent successors can lead to developmental disturbances in the permanent dentition. Developmental disorder can occur in any tooth. One of the most common teeth affected is lateral incisor. These developmental anomalies can cause various clinical problems. Clinical and radiographic characteristics of these anomalies may sometime present confusing picture. Therefore, recognition of this condition, early diagnosis, and treatment are important to avoid complications. High prevalence of dental trauma in young children emphasizes the need of educational and preventive programs in schools. Dentist plays important role in early diagnosis of disturbances in the permanent successor teeth by rigorous clinical and radiographic follow-up examination.


Accurate and timely information is crucial to optimize resources. Sensors determine clay, organic matter, moisture, and nutrients of soil. Sensors at various locations are connected using different technologies. Its data will be automatically reported to cloud without any internet connection. Sensors broadcast data to local base stations (LBS) at different ranges of distances using WiFi, LPWAN, LoRa, Bluetooth, etc., and then to central base station (CBS), which is far away. Modulation, coding techniques, and line of sight keeps signal intact. Data from CBS goes to cloud for analysis, visualization, and trend analysis. This helps farmers to get frequent and real-time data without actual need of physical presence. It reduces manpower, water usage, and other costs of agriculture and has positive environmental impact. Integration with other data like weather forecasts gives more precise information. Convergence of technologies, sensors, cloud, automation, etc. without human interaction contributes to IoT.


The social change in New Spain was also reflected in the students of the Royal University of Mexico. Although this was originally planned for the Spanish, mainly, in the seventeenth century other groups were present. Mulattoes, Indians and Filipinos demanded major studies and degrees, in the search to improve their living conditions and the social advancement of their families. This aspiration was rejected by intolerant sectors of Spaniards, causing rejections from students and various controversies that the university leaders had to resolve


SIn,.-Apropos to the discussion which has recently occupied a place in your columns on Turkish baths, permit me to call the attention of your readers to a very simple method of exciting the emunctory function of the skin, in my opinion quite as effectual, and possessing advantages peculiarly its own. I allude to the lamp-bath, which is thus applied. The patient, in puris itaturalibus, is seated on a common wooden chair with bis feet upon a low stool, the body is then envelopedl in two or three blankets, the head being excluded, and a large spirit lamp placed under the seat; in a few minutes the skin becomes moist, and in about a quarter of an hour the perspiration streams down the body and is collected in beads upon the face; this is kept up so long as may be considered necessary, the patient meantime drinking one or two tumblers of water, when the blankets are rapidly removed, and he is subjected to a douiche of two pails of cold water, and dried with much friction, after -which a smart walk in the open air may be taken. The process does not occupy more than three-quarters of an hour, and may be applied at any time in the invalid's bedroom. I believe the profuse perspiration thus excited, and which may be carried to any reasonable extent, effects all the good thiai can be accomplished by the calidaria of the Turkish baths, while its extreme simplicity and portability ensure for it advantages as a therapeutic agent that these iustitutons can never command; among the more important of which, I would enumerate the fact that during the whole process the patient breathes cool air instead of that of an apartment heated to an extent necessary to produce such an effect, and indeed may, as I have seen in the summer time, be placidly seated regarding a beautiful landscape from an open window during its administration; thus the ill effects of respiring hot air experienced by many even in over-heated rooms, such as difficulty of breatlhing, violent palpitation, giddiness, faintness, etc., are all avoided; while the fact that it is used in the patient's own apartment, and may at first be moderated to any extent that may suit his fancy, materially lessens the risk of disagreeable nervous symptoms very likely to be experienced in invalids; who, morcover, are frequently unable or unfit to visit the public baths, or unwilling to expose their infirmities to the gaze of strangers, who, I may observe, en passnfltt, would be little likely to patronise establishiments where they were liable to meet as "companions of the bath" persons suffering from lepra, psoriasis, dropsies, influenza, etc. I have seen the above process attended with the very best effects in some cases of obstinate skin-disease, in rheumatism, edematous swellings, catarrh, sypihilis, albuminuria, torpor of the liver, etc.; and have more particularly noted its good effects in cases whiere individuals, from leading a sedentary an& town life, had grown fat, pallid, flabby, and altogether out of condition. Such speedily lose fat and gain muscle: the complexion clears; the colour heightens; the skin becomes smooth and polished. They experience a feeling of lightness and buoy. uncy to which they have long been strangers, and soon add to the appetite of a wolf the digestion of an ost-ich. It is seldom omitted in the treatment of persons subjected to what is known as the water-cure, and has been employed for years in the hydropathic establishments to which used up men about town notoriously resort, and with the best -esult, to recruit their injured health and shattered frames. By fixing a small sauce. pan, containing water, over the lamp, it is converted into a vapour-batb, medicated or not; and may be used for sulphureous and niercurial fumigations. I must confess that I cannot see the force of the objections that I have hear-d urged against the employment -of this simple remedy. WVe are told-1. That the patient is surrounded with an atmosphere deprived of its oxygen, and loaded With carbonic acid, the product of the combustion of the spirit of the lamp; and that this, by interfering with the respiratory function of the skin, must bave a most deleterious effect; 2. That the atmosphere surrounding the patient is stagnant, and does not circulate; and 3. That it is an advantage for the patient to breathe the heated air, as was done in the baths of the ancient Romans. With regard to the fint, it appear to me to be of vey light importance if the air were loaded with carbonic aid, an be respiratory funotion of the skin, while bathed ina perspr. ion, which is coursing on all sides in little rivulets, in qtity iufflcient to saturate the blanket or cushion on which the ,atient is seated, and drops from the footstool to the floor, nust be reduced to nothing; but I cannot admit that the )atient is surrounded by such an atmosphere, as the specific ;ravity of the carbonic acid would ensure its falling below the Level of the chair on which the patient is seated. In answer to Lhe second, I contend that tho air surrounding the patient is aot stagnant, but circulates freely; cold air, according to a natural law, rapidly taking the place of the hot as fast as hleated, which must necessarily be the case, unless the patient were hermetically sealod up, when the combustion of the lamp could not be supported. With regard to the last, I own that I am sceptical as to the benefit to be derived by a delicate invalid from inspiring air hot enough to cook a chop. I am, etc. CHAiuxs TAYLOR, Late Physician to the Asylum, Wfaltont, Liverpool.


BACKGROUND
Cerebral cavernous malformations (CCM) comprise enlarged capillary cavities in the central nervous system, with possible retinal or cutaneous vascular malformations. This condition is associated with CCM1, CCM2, and CCM3 gene mutations.

OBJECTIVE
Cutaneous clinical, histological and cerebral MRI findings, including CCM1, CCM2, and CCM3 gene sequencing, of two unrelated, neurological symptom-free patients who consulted for late-onset of deep multiple cutaneous angiomatoid lesions, are described.

RESULTS
The diagnosis of multiple cutaneous angiomatosis was confirmed and related to CCM as detected by MRI in both cases. Analysis of our patients showed normal nucleotide sequences of the genes proposed.

CONCLUSIONS
A progressive late-onset of multiple, deep cutaneous venous malformations may indicate the need to investigate a potential coexistence of CCM by MRI. Early diagnosis and prompt treatment is required in these patients. The absence of CCM1, CCM2, and CCM3 mutations might indicate that different genes could be involved in the pathogenesis of these late-onset patients. Careful questioning about family history of CCM is important; our first patient's daughter had a history of cerebral cavernoma.


Early practical experience, based upon empirical observations strongly indicates that using classes as the basis for eeort estimation, can help to achieve DeMarco's holy grail. In providing evidence for this claim this position paper will describe (i) empirical size observations; (ii) estimations processes, based upon these observations ; and (iii) initial experiences using these processes. This paper will conclude with lessons learned and further work to be done.


In the presence of sensor gain and phase uncertainties for sensor array, this paper addressed the problem of High-resolution estimation of DOA-Doppler frequency for multiple signals. By utilizing rotational invariance technique and collecting data of signals at two different carrier frequencies, the proposed method can precisely estimate DOA-Doppler frequency of multiple signals and sensor gain and phase factors. Simulation results illustrate that this method has superior performance.


The present invention discloses a method for obtaining the planning data according to the regional power grid Roadmap, comprising: a region dividing Roadmap; legend legend information obtaining respective region; body region separating the same into separate sub-region will plans FIG.; FIG respective sub binarization process; binary edge image extraction; edge extraction result obtained using each sub-graph corresponding .dxf file; .dxf file into the respective sub FIG AutoCAD formed in different respective layers CAD graphics; CAD drawing according to the area of each layer and the layer plan property represents obtain network planning data for the region. Using the image processing method of the present invention is directly transformed by industrial development plan schematic view in plan of a CAD drawing in different layers, which contributes to electricity grid during the planning division properties, areas designed such that results more network planning reliable and fast.


Wind farms are often located at high latitudes, which entails a high risk of icing for wind turbine blades. Traditional anti-icing methods rely primarily on manual observation, the use of special materials, or external sensors/tools, but these methods are limited by human experience, additional costs, and understanding of the mechanical mechanism. Model-based approaches rely heavily on prior knowledge and are subject to misinterpretation. Data-driven approaches can deliver promising solutions but require large datasets for training, which might face signi fi cant challenges with respect to data management, e.g., privacy protection and ownership. To address these issues, this paper proposes a federated learning (FL) based model for blade icing detection. The proposed approach fi rst creates a prototype-based model for each client and then aggregates all client models into a globally weighted model. The clients use a prototype-based modeling method to address the data imbalance problem, while using the FL-based learning method to ensure data security and safety. The proposed model is comprehensively evaluated using data from two wind farms, with 70 wind turbines. The results validate the effectiveness of the proposed prototype-based client model for feature extraction, and the superiority over the fi ve baselines in terms of icing detection accuracy. In addition, the experiment demonstrates the promising result of online blade icing detection, with almost 100% accuracy. © 2022 The Author(s). Published by Elsevier


PENNSYLVANIA never sponsored a trade in slaves that rivaled in scope or dimension the traffic in the colonies farther south or in such northern provinces as New York, Rhode Island, and Massachusetts. The number of blacks imported into Pennsylvania was small when compared with the number brought into many of the other colonies. Similarly, unlike the situation that prevailed in New York and the New England provinces, merchants in Pennsylvania were not extensively involved in transporting slaves from Africa to the West Indies and other New World ports where a continuing demand for African laborers existed. Nevertheless, a surprisingly large number of Philadelphia merchants engaged in the slave trade, some by selling on commission blacks shipped north from the islands, others by sending vessels to the west coast of Africa for cargoes of slaves. A further indication of the importance of the slave trade in the Pennsylvania area is the fact that provincial legislators found it expedient to impose duties on imported blacks. Pennsylvania thus joined eight other mainland colonies in placing duties on slaves. In the case of some, New York and Virginia, for example, such duties were consistently maintained during the eighteenth century. There were periods before the American Revolution when blacks entered Pennsylvania duty-free, but it may still be instructive to examine the Negro duty policy that was followed there in an effort to grasp the meaning of that policy. That examination will assist in understanding the attitudes of white colonists toward the slave trade; it


Introduction N-3 fatty acids are essential for normal growth and development, and may play an important role in prevention of coronary artery disease, hypertension, diabetes, arthritis, other inflammatory and autoimmune disorders and cancer in humans (Simopoulos, 1999). Fatty acid profiles of broiler meat may be modified by adding fish oils to the diet (Lopez-Ferrer et al., 2001). When meat is enriched with PUFA, particularly n-3 long-chain fatty acids (C 20), all sources of added vegetable oils seem to be less effective than marine oils (Bou. R et al., 2004). The purpose of this experiment was to study the effect of dietary fish oil on fatty acid composition of thigh and breast meat in broiler chickens.


New consumption patterns and the impact of piracy are radically disrupting the independent film business, reducing revenues and increasing competition. However, innovative producers are responding by leveraging digital marketing and distribution technologies to develop new ways of creating awareness and delivering films to audiences. The creation and application of tools for direct audience engagement is changing the way the industry is organised and how market activity is managed. Producers are able to use film trailers as 'socially distributed points-of-sale' and extra-filmic content throughout a film's life to develop interest, capture data and exploit intellectual property rights internationally. This chapter presents a detailed case study of two feature documentaries to provide insight into emergent technological, economic and organisational developments in film marketing practice. We analyse the financing and implementation of campaigns that use spreadable Video-on-Demand tools, social media outreach strategies and data management processes. This research contributes new evidence to demonstrate the evaluative and mediating role of Digital Engagement Metrics in terms of market performativity, the productive shaping of economic transactions.


The present study focused on the color of clothing for elderly Korean women, from the viewpoint of helping elderly people live more interesting lives with regard to their clothing, considering that the Korean society will become elderly-oriented in the near future. We took photographs of the elderly served as the models, displayed them on a computer screen, and produced 75 colors of the clothing in the elderly using computer graphics. The 75 colors were evaluated by 2 groups, one of elderly Korean woman group and a group of female students. We compared the ideal colors for and the colors actually worn by elderly people. The evaluation of the clothing colors for elderly women differed between the elderly woman group and the female student group. Analysis of images of the clothing colors selected by the elderly women showed that they attach importance to elegance when selecting clothing colors and have a strong desire to become active. The images held by female students concerning ideal clothing colors for elderly women closely pertained to commonness and inactivity.


The hybrid car includes internal combustion engine driving an electric generator and motor are connected via a first clutch. Stop request for the system in a stopped state, reducing the rotational speed of the internal combustion engine to the resonance frequency band greater than a predetermined speed by a predetermined negative torque of motor generator via a first clutch to the internal combustion engine is applied. After the start of disengaging the first clutch. Separated from within a predetermined time after the start, the engine speed to a predetermined resonance frequency band or less. Thus, the operation of the internal combustion engine in a stopped state to stop operation of shortening the time required for the operation is stopped.


In this paper we present a fast parallel algorithm for constructing a depth first search tree for an undirected graph. The algorithm is an RNC algorithm, meaning that it is a probabilistic algorithm that runs in polylog time using a polynomial number of processors on a P-RAM. The run time of the algorithm is &Ogr;(TMM(n)log3n), and the number of processors used is PMM(n) where TMM(n) and PMM(n) are the time and number of processors needed to find a minimum weight perfect matching on an n vertex graph with maximum edge weight n.


Two patients with ballism were treated successfully with diazepam. It is suggested that diazepam acted as an indirect GABAmimetic drug to correct a functional GABA deficiency secondary to hyperactivity of the dopamine system in the subthalamic nucleus as a cause for ballism.


ABSTRACT: Differentiation of specific epithelial cell lineages during development, as well as epithelial plasticity in response to heterologous cell‐to‐cell cross talk during adult life, accounts for the large variety of functions which are performed by the mucosal surfaces found in the human body. Among its functions, the digestive mucosa is able to sample antigens and microorganisms through M cells of Peyer's patches follicle‐associated epithelium, in order to trigger the development of either tolerance or immune responses. At least in the gut, M‐cell formation is immunoregulated. Close contact between immune cells and intestinal epithelium modifies the permeability of the epithelial barrier by inducing the conversion of enterocytes into M cells, offering at the same time an opportunistic way of invasion for pathogens. These lympho‐epithelial interactions triggering M‐cell formation have now been modeled in culture.


No abstract. 15:021088A method of purifying a quantity of graphite containing one or more impurities having or liable to have long life activity or activities after irradiation in a nuclear reactor is described. It consists of heating the graphite in a furnace to at least 2500 deg C in a stream of inert gas. The heat-ing may be carried out in any suitable furnace and it will be necessary to ensure, by maintaining a flow of inert gas that, on cooling, the impurities do not condense back upon the quantity of graphite, possibly in the form of an article or body, being treated. This method may be applied to the purification of machined graphite support sleeve for fuel element of a nuclear reactor. (N.W.R.)


The invention provides a method for depolymerizing waste polyester, which comprises the following steps of: adding methanol and cosolvent gas into a reaction system and utilizing the methanol and the cosolvent gas for depolymerizing waste polyester-polyethylene glycol terephthalate material so as to obtain dimethyl terephthalate and ethylene glycol on thesupercritical condition. According to the invention, as the cosolvent is added, the depolymerizing reaction temperature of the waste polyester is lowered and the reaction time is shortened, thereby reducing the energy consumption. As the cost of the cosolvent is relatively lower and easy for recycling, the recycling cost of the waste polyester is further lowered. In the method, the degradation rate of the olyethylene glycol terephthalate is more than 99.9 percent, the monosomic selectivity is high, and the content of oligomers in the product is low.


Magnesium AZ91D plates were welded by an electron beam (EB). The integrity of the welded specimens was investigated by X-ray radiography and ultrasonic techniques. Optical and scanning electron microscopy were used to investigate the microstructural changes that occurred during welding. Mechanical properties were determined by standard tension tests. It was found that Mg AZ91D cast alloy can be EB welded with a negligible amount of dis- continuities and with a minimal heat-af- fected zone (HAZ). The rapid melting and subsequent resolidification during weld- ing induces microstructural refinement, which increases both strength and duc- tility of the alloy. It was also observed the microstructure is finer with less heat flux.


This paper explores the concept of "causative" fault – with an emphasis on proximate and actual cause – as a substitute for modern strict liability.


A collection of short stories written by the same author as "Man of Letters", "Collected Stories", "Marching Spain" and "The Spanish Temper".


Our paper investigates the values fostered and inhibited by current Brain-computer Interface systems for the physically disabled. We report on a study conducted among 12 physically disabled individuals by employing Value Sensitive Design, a tripartite methodology accounting for human values in the design process. Our study reveals that current systems restrict independence, articulation, recreation and customization. We also elicit values that we believe are important in designing Brain-computer Interfaces family-centricity, a sense of community, altruism, intellectual involvement and autonomy. We discuss how Value Sensitive Design applies to the unexplored domain of Brain-computer Interfaces.


The TV industry in Hong Kong has experienced great changes over the past 10 years.The article compares the main characters of Hong Kong's TV industry before and after returning to China,and tries to find some conclusions for the future.


In the general population, serum concentrations of DDT and DDE are reflective of incidental exposure to this pesticide. Theorectically such exposure could be due to contamination of food, air, water or other sources; previous studies based on pesticide concentrations in food had concluded that 80-90 percent of human exposure were from dietary source of DDT. Recent studies on the distribution of these residues in several populations have not entirely supported this concept and in warmer climates the data has suggested that non-dietary sources, particularly dust, are a significant mechanism of DDT pollution in man. A health and pollution serological survey in an isolated island in the Caribbean provided an ideal opportunity to test this hypothesis. In a survey of 254 islanders average serum total DDT residues were almost twice as high than the matched controls from the mainland in South Florida. Studies of DDT concentrations in food, air and water revealed only trace amounts of this pesticide, but in 15 homes the average total DDT concentrations in house dust were 129 ppm as compared to only 8.5 ppm in the exterior soils. The data showed that house dust was a sample of air collected from the interior of a home after sweeping from particles of 0.3 micron size, suggested that inhalation may be another mechanism of incidental exposure. A pesticide use questionnaire revealed that 45 percent of persons using domestic pesticides favoured a 5 percent DDT spray solution for the control of roaches and flies; average serum total DDT levels were 117 ppb on the island compared to 68 ppb in Dade County and no obvious adverse health effects were observed with the serum concentrations of DDT and its metabolites (AU)


Since 2005, several new vaccines have been approved by the US Food and Drug Administration (FDA). These additions to the universal childhood immunization schedule now include vaccines to protect against rotavirus gastroenteritis, human papillomavirus infection, meningococcal infection, and pertussis in adolescents and adults. While the individual and public health benefits of these efforts are proven, intuitive, and progressive, healthcare providers are left wondering why we still do not have a safe and effective respiratory syncytial virus (RSV) vaccine. RSV disease is a prime target for vaccine development because RSV infection is ubiquitous. Nearly all affected children are infected before their second birthday, and between 1 and 3% will require hospitalization. The primary risk factors for the development of serious RSV infection include prematurity, chronic lung disease, and hemodynamically significant congenital heart disease. Secondary risk factors include low birthweight, multiple gestations (twins, etc.), young siblings in the same household, day-care attendance, and male gender. Term infants born with low cord blood RSV-neutralizing antibody titers are known to develop RSV infection earlier in life, presumably due to the lack of protective maternally transmitted antibodies.


Eosinophilic lung diseases represent a group of disorders in which lung infiltrates seen on a chest radiograph, may or may not be accompanied by peripheral blood eosinophilia. The causes are varied, and range from drug ingestion, parasite or fungal infection, or else, may be idiopathic. The clinical manifestation of these disorders may be mild or severe, depending on the underlying condition. A full history and examination, along with radiological imaging, bronchoscopy, and serological tests are useful in reaching a diagnosis. Treatment with corticosteroids usually results in a good clinical outcome, if the diagnosis is suspected and made early. Early treatment with high dose corticosteroids may be life saving in some patients, whilst other patients require prolonged and sometimes recurrent courses of corticosteroids, due to the chronic relapsing nature of their condition.


Electro-conductive poly(vinyl alcohol)/multi-walled carbon nanotube (PVOH/MWNT) and poly(ethylene-co-vinyl alcohol) (EVOH)/MWNT nanocomposites were prepared by precipitation saponification method. The MWNT was functionalised by electron beam irradiation in air at 1200 kGy doses. The electrical resistivity, thermal and mechanical properties, and positive temperature coefficient (PTC) behaviour of these nanocomposites were investigated. The melting and crystallisation peak temperatures of both nanocomposite systems were shifted at a higher temperature with the increase in saponification time. Their crystallinity and mechanical strength also increased with saponification time, indicating an increase in intermolecular hydrogen bond between vinyl alcohol groups. With the saponification time, PTC peak temperature of EVA28/MWNT and EVA40/MWNT nanocomposites was shifted at a higher temperature and followed by a negative temperature coefficient (NTC) of resistivity. However, the saponified PVAc/MWNT nanocomposites showed only NTC behaviour over a temperature range of 30–140°C.


Using Stuart Hall's concept of articulation, which sutures seemingly incongruent analytics, this article juxtaposes queer theorizing and postcolonial projects in order to contribute to the examinations of empire, education and decolonization. It foregrounds the queer approaches of working within, through and beyond the framework of sexuality to investigate the themes of exclusion, normalization, and subject position and agency. It offers a review of the scholarly literature in queer, postcolonial and education studies, and engages the author's initial research formulations on Filipino/a schooling and United States imperialism in the early twentieth century. By interrogating and bringing together theoretical perspectives, empirical findings and political movements, the article aims to open discursive and structural spaces for revolutionary solidarities and interventions.


perplexing. Recognition that money, happiness and garlic are important factors related to why people innovate represents a quantum leap toward comprehending the epistemological mysteries of innovator motivation. Comprehension of the meaning of M, H, and G and their interrelationships represents a challenge certainly within reach of today's sophisticated research community. I challenge members of this group to finish Ferment's work.


This study started from the question of the habitual on the assumption that Sin-pa is a obvious concept. The obviousness based on the several facts : Sin-pa play derived from Japan, it began at 1910's, 'Sin-pa' have communicated as the synonym of popularity. However, actually it is all sure that Sin-pa have been in existence as a signifier. From my point of view, I feel the origin and formation of Sin-pa illogical. The reason is that both induction and deduction have the difficult points. For settlement the dilemma, I choose two courses. One is the study of the aspect that a signifier joined a signified in special situations. The other is the study of the historical condition of Sin-pa to enabling the positivity of the discourse. Then, I studied three situation of forming the signified in order.


We study the neutral filling ABC-stacked trilayer graphene with a long-range Coulomb interaction. The extremely large density of states near Dirac points leads to more plausible formation of spin ferromagnets, and our calculation indicates that the spin split energy approximates to 32 meV. Electron and hole carriers coexist in this spontaneous ferromagnetic system. The Coulomb interaction between carriers with opposite charge leads to triplet exciton condensation, namely, a spin superconductor. Using a BCS-type self-consistent calculation, we demonstrate the exciton condensation energy gap is about 7.8 meV. Further, we consider the thermal fluctuations and determine the Berezinskii-Kosterlitz-Thouless critical temperature to be around 11 K.


We are developing an electric wheelchair that can be operated by a gesture interface to support persons with severe disabilities. The non-contact non-constraining gesture interface system recognizes four shoulder states (both shoulders normal, raising right shoulder, raising left shoulder, and raising both shoulders) by using a stereo camera. We expected the system to have a wide range of uses and evaluated its valuation basis.


The article highlights the issues of necessity of introduction of state-private partnership in the research sector, discusses the advantages of this mechanism in promoting innovative development. The main attention is paid to the analysis of forms and methods of financing scientific research activities in the framework of the PPP, which formulates the principles of improvement of interactions and relationships between the state and business in order to enhance their mutual cooperation.


Serum response factor (SRF) is a transcriptional factor that plays an importantrole in cell growth and differentiation for several types of cells. The expression of SRF in cholan-giocarcinoma (CC) and its potential role has not been examined. The aim of this study was todetermine the relationship between the expression of SRF in CC and the clinicopathologicalparameters, as well as patient survival.


Objective:To observe the effects of recombinant resistin(RR) on proliferation,invasion,metastasis and matrix metalloprotease-2(MMP-2) expression of human cholangiocarcinoma cell line QBC939.Methods:MTT and Transwell were used to analyze the effects of different concentrations of RR on proliferation,invasion and migration of QBC939 cells;the expression level of MMP-2 protein in QBC939 cells was examined by Western blot.Results:RR significantly promoted the proliferation of QBC939 cells when the concentration of RR was higher than 10 ng/ml(P 0.01),the effect was dose-dependent to some extent.After treated with 10,50,100 ng/ml RR for 24 h,the capacity of invasion and migration of QBC939 cells were significantly stronger in RR group than in control group(P 0.01).The expression of MMP-2 protein was up-regulated significantly in QBC939 cells treated with resistin for 24h.Conclusion:RR significantly increases the invasion and metastasis of QBC939 cells in vitro,and the possible mechanism may be related with up-regulation of MMP-2 level.


Removal of an oxide layer from all surfaces of a metal plate using an arc in vacuum is conducted for this study. Results confirmed that cathode spots that appeared on the side faced to anode were able to exist on another side opposite from the anode as well. Although some features of the cathode spots are not unusual, some characteristics disagree with conventional explanations for low-vacuum arc behavior.


A continuous flow process and apparatus to achieve nitrification maintaining short, sequentially disposed into the water tank, the aeration system and the precipitation system, into the tank through the pump into the reaction cell communicates completely mixed, completely mixed reactor tank in communication via conduit Sedimentation tank. Reaction cell provided with a DO probe, pH probe, the DO \ instrumentation line connects the pH data to a PLC control system, PLC control system and an air compressor. In the batch start-up phase, PLC control system can change characteristics according to the DO and pH values, close the switch of the air compressor in the stable maintenance phase, PLC control system capable of real-time adjustment of the opening degree of the air compressor or the rotational speed, control of reaction tanks DO concentration in the optimum range. The present invention achieves partial nitrification quick start and maintain stability, to solve the partial nitrification in a continuous flow process to the domestic sewage difficult to start and difficult to achieve in question. Primarily of Municipal Sewage or wastewater with high ammonia to achieve short-cut nitrification processes in a continuous flow aeration energy savings.


With the development of blockchain technology, the use of cryptocurrencies in online payments has become increasingly prevalent. Litecoin, proposed in 2011, is currently the fifth-largest cryptocurrency in market value. Due to certain characteristics, such as the use of pseudonyms as transaction addresses, user privacy could be protected to some extent. However, there are some problems about its privacy guarantees.In this paper, we aim to reveal the severity of deanonymization attacks on online Litecoin payments. Firstly, we simulate purchases on merchant websites accepting Litecoin and monitor trackers embedding on information and payment pages. Secondly, we conduct transaction-linkage attacks on simulated digital and physical transaction flows, respectively. Our results show that a tracker is more likely to find the target transaction on Litecoin blockchain by collecting the digital transaction flows and implementing transaction-linkage attacks. The number of digital transaction flows with anonymous set size 1 and 2 account for 95% and 5% of all digital transaction flows, respectively. The success rate of the transaction-linkage attack is 0.975. To get the optimal uncertainty parameters of transaction-linkage attacks, we introduce a refined deanonymization attack by making real purchases. Finally, we present two new privacy protection measures against transaction-linkage attacks.


Insecticides were evaluated as foliar or soil treatments in 1968-69 for control of C-biotype Schizaphis graminum (Rondani) on sorghum, Sorghum bicolor (L.) Moench. Foliar treatments of disulfoton, monocrotophos, parathion, dimethoate, malathion, demeton, carbophenothion, endrin, endosulfan, phorate, CL-47031 (cyclic ethylene (diethoxy-phosphinyl) dithioimidocarbonate), and carbofuran provided effective initial control, but residual toxicity varied. In general. most treated plots yielded more seed per acre than untreated plots; however, increases were statistically significant in only 1 test. Excellent control of greenblugs was obtained when granular and liquid formulations of disuifoton, phorate, and carbofuran were applied in the furrow at planting time. Granular formulations provided better season-long control than did liquid formulations and did not affect plant emergence adversely. Seed yields were significantly increased with most soil treatments.


Objective To investigate the awareness of preventing osteoporosis from calcium supplements in olderwomen of Wujiaochang communities and assess the intake of calcium from dietary.Methods Randomly extract 100 women(40 years)in Wujiaochang Street of Shanghai Yangpu District to investigate the way of life,cognition,attitudes and knowledge about osteoporosis.Results The lack of knowledge about preventing osteoporosis by diets in the older women was extensive and only 4% of the people understood that postmenopausal women should intake 1 000-1 500 mg of calcium everyday.There was misunderstanding about how to supply calcium and inadequate intake of high calcium food.The average daily intake of calcium was 700-900 mg in surveyed subjects.Conclusion Older women need to increase the intake of dietary calcium and eat more milk,dairy products,seafood and other foods of high calcium.Health education should be strengthened to increase the knowledge about osteoporosis in middle-aged women.


The introduction of outcomes-based education in South Africa changed the way in which learning facilitation is viewed .and conducted in a number of ways. The emphasis at present is on assessing learners on an ongoing basis, instead of using examdriven assessment, with a renewed emphasis on developing critical thinking, reasoning and reflection in the classroom. The emphasis is also on the application of content to reallife situations instead of textbook-bound situations. Learners are offered constant feedback in an attempt to motivate them to take responsibility for their own learning, thereby reaffirming their role in the learning process. This shift from educational inputs to learning outputs, from a narrow focus on classroom processes to learner achievements, and from educator actions to learner outcomes is common to first world and developing countries. It is within this context that the insights presented in this book should be evaluated.


In this work, we have studied many concepts to design a new MOSFET structure. We have chosen a superjunction based structure made by deep etching and boron diffusion. The main part of the work was to optimize this structure. For this, we have studied many technological parameter's influence on the "Breakdown voltage/On-state resistance" trade-off. We have developed a new innovated junction termination in order to sustain the desired breakdown voltage. It was necessary to identify the process critical steps. From this point, we have fabricated a 1200 V diode which enabled to validate some of these steps but also the original termination.


The first cold-in-place recycling project using a specially formulated emulsified recycling agent as the additive was performed on a project in Fresno County, California. The objective of this project was to provide guidelines for the use of a one-component, emulsified recycling agent. The project indicated that a one-component, emulsified recycling agent was effective not only in its application, but it also restored necessary properties to the aged asphalt, reversing its aging process. This is essential if CIR is to be a cost-effective procedure for rehabilitating aged asphalt pavements.


In two-dimensional prospecting the conventional interval between two neighboring indexes of lithologic index quantifier is 25% such quantifier has contributed to a certain degree in application to regional prospecting while it cannot meet the accuracy requirement of reservoir prediction in three dimensional prospecting. This paper suggests in 3D prospecting region by means of raising the resolution of lithologic index quantifier the accuracy of lithologic prediction can be improved. Actual data have verified that the seismic prediction result is basically correspondent with drilling logging recorded result. The accuracy of prediction is obviously improved.


Leiden University, Leiden, Netherlands Onomastics and the Reconstruction of the Past: Rethinking Totemism in Semitic Traditions Voprosy onomastiki, 2019, Vol. 16, Issue 1, pp. 19–35 DOI: 10.15826/vopr_onom.2019.16.1.002 Language of the article: English ___________________________________________ Hekmat Dirbas Leiden University, Leiden, Netherlands Onomastics and the Reconstruction of the Past: Rethinking Totemism in Semitic Traditions Вопросы ономастики. 2019. Т. 16. No 1. С. 19–35 DOI: 10.15826/vopr_onom.2019.16.1.002 Язык статьи: английский


We have created control samples of boron content. Said samples are dry mixes which contain the component to be determined (boron), calcium, magnesium, ferrum(III) ions and nitrate-, sulfate-, chloride ions. Fluometric and fotometric metods of boron content determination in water solution have been used to establish the metrological characteristics.


The extent of stock market performance cannot be dissociated from the political environment in which it is operating. This reality has motivated a plethora of studies on the relationship between political system and stock market performance in both developed and developing countries, with the political experience and stock market performance in developing countries not akin to that of developed countries.

In light of this, this study conducts an in-depth analysis of stock market performance under the military regime and the civilian regime in Nigeria. Monthly data that covers the period from 1985 to 2018 is used for the implementation of our objective. Using a standard robust regression, we generally find that the stock market performs better under the civilian regime than the military regime.

However, accounting for inflation and stock market volatility undermines the gains in the stock market under the civilian regime and almost swing the gains in favour of the military regime. The political regime becomes irrelevant when we control for other macroeconomic factors (exchange rate, money supply, output and inflation) determining stock market performance.

Given our findings, we advocate for implementation of policy interventions and regular supervision of the market activity to stem the tide of stock market volatility either caused by external or internal shocks.


ABSTRACT In this paper, we consider the shape instability of ferroelectric wavy domain wall that moves uniformly in the ferroelectric capacitor under the constant uniform electric field. The retardation of the bulk screening of residual depolarization field and existing of the surface dielectric layers were taken into account. It was shown that the spatial distribution of the electric field in the ferroelectric plate led to topological instability of the moving wavy domain wall. The obtained results are important for the formation of the self-assembled domain structures in ferroelectrics.


Objective To investigate the diagnosis value of tuberculous spondylitis(TBS)with MRI and Diffusion-weighted imaging(DWI).Methods 13 cases with TBS were underwent routine MRI scaning and echo-planar DWI(EPI/DWI).Findings of MRI and DWI in TBS with abnormal vertebral,intervertebral disc and soft tissue surrounding lesions were analyzed.Results 2 or more vertebral levels were involved in all 13 cases with TBS,and hyperintense signal on DWI.Intervertebral disc was involved in 10 cases,and thin and smooth abscess wall surrounding vertebral in 11 cases of all 13 cases with TBS.Conclusion There were characteristic feartues of routine MRI and DWI with TBS.


Steady-state and scale-resolving simulations have been performed for flow in and around a model scramjet combustor flameholder. The cases simulated corresponded to those used to examine this flowfi...


Vladimir Nabokov, one of the greatest writers of the twentieth century, is best known for having published in 1954 in France his novel Lolita. Many publications report his psoriasis, but none was interested in its psychological repercussions. He and his wife Vera Slonim remained inseparable from 1923 to 1977, when the writer died. In 2017, the Russian letters to Vera from 1923 to 19771 were translated into English by Olga Voronina and Brian Boyd (figure 1). We searched for all the passages in which Vladimir Nabokov refers to his psoriasis. Vladimir Nabokov reported his psoriasis for the first time on 7 July 1936, which heals after a solar exposure (p.127). This article is protected by copyright. All rights reserved.


In movement analysis frameworks, body pose may often be adequately represented in a simple, low-dimensional, and high-level space, while full body joints' locations constitute excessively redundant and complex information. We propose a method for estimating body pose in such high-level pose spaces, directly from a depth image and without relying on intermediate skeleton-based steps. Our method is based on a convolutional neural network (CNN) that maps the depth-silhouette of a person to its position in the pose space. We apply our method to a pose representation proposed in [16] that was initially built from skeleton data. We find our estimation of pose to be consistent with the original one, and to be suitable for use in the movement quality assessment framework of [16]. This opens the perspective of a wider applicability of the movement analysis method to movement types and view-angles that are not supported by its skeleton tracking algorithm.


The paper presents the study of peculiarities of the muscle development of the carcasses of Simmental, Kazakh Whiteheaded heifers and their cross breeds of the I generation. The control slaughter of 3 heifers of different genotypes was carried out at 18 months of age: I – Simmental, II – Kazakh Whiteheaded, III – 1/2 Kazakh Whiteheaded x 1/2 Simmental. To evaluate the development of a set of muscles and individual muscles, left semi–carcasses were prepared along the anatomical regions. The paper presents the analysis of the set of muscles in relation with their joints and topographic location. The development of muscles is described in terms of the absolute weight of individual muscles and the muscle sets. The paper states the advantage of crossbred heifers over their herdmates in the development of spinal muscles by 6.30–33.07 %, the weight of shoulder muscles – by 5.96–11.29 %, the entire thoracic limb – by 5.97–5.65 %, the weight of muscles of the entire pelvic girdle – by 22.13–17.19 %.


Glioblastoma multiforme (GBM) is one of the most lethal human cancers and poses a great challenge in the therapeutic interventions of GBM patients worldwide. Despite prominent recent advances in oncology, on an average GBM patients survive 12–15 months with conventional standard of care treatment. To understand the pathophysiology of this disease, recently the research focus has been on omics-based approaches. Advances in high-throughput assay development and bioinformatic techniques have provided new opportunities in the molecular analysis of cancer omics technologies including genomics, transcriptomics, epigenomics, proteomics, and metabolomics. Further, the enormous addition and accessibility of public databases with associated clinical demographic information including tumor histology, patient response and outcome, have profoundly improved our knowledge of the molecular mechanisms driving cancer. In GBM, omics have significantly aided in defining the molecular architecture of tumorigenesis, uncovering relevant subsets of patients whose disease may require different treatments. In this review, we focus on the unique advantages of multifaceted omics technologies and discuss the implications on translational GBM research.


Recent investigations of dimethyl acetylene and perfluorodimethyl acetylene have suggested that the selection rules for a freely rotating ethane‐type molecule should be those of the point group D3d rather than D3h. A demonstration that this holds under the usual Born‐Oppenheimer approximation is given. Possible deviations from this in any particular case should depend upon the characteristics of the individual molecule.


Purpose: To investigate the efficacy of fibrin glue for conjunctival closure in vitrectomy. Methods: Two hundred five eyes of 200 patients who underwent conjunctival closure for vitrectomy with a minimum follow-up period of six months were evlauated. Postopertive pain, foreign body sensation, tearing, subconjunctival hemorrhage, surgery time and complication were evaluated prospectively in 105 eyes of 100 patients undergoing surgery with fibrin glue, and in 100 eyes of 100 patients undergoing surgery with sutures. Results: One day postoperatively, pain scores (p


The nucleophilic Fe complex Bu4N[Fe(CO)3(NO)] (TBAFe) has been used as a highly active catalyst for the mild hydrosilylation of a variety of functionalized aldehydes and ketones using inexpensive PMHS as stoichiometric reductant. The corresponding alcohols were obtained in good-to-excellent yields at low catalyst loadings of only 1 mol-% and reaction temperatures of 30–50 °C.


The mechanism of catalytic hydroxylation of phenols, based on the principles of the metallocomplex catalysis and considering the effect of varying initial parameters, including pH of the medium, is proposed in analyzing the regularities of the peroxide oxidation of mono- and dioxybenzenes and the overall mathematical model of the catalytic hydroxylation of phenols. The physical meaning of all terms in the kinetic equations of the model is considered, and the corresponding constants are determined. The possible structure of the intermediate hydroxylation complex and the effect of cerium sulfate additives on the reaction selectivity are discussed using the spectral data.


The response functions of the Bonner Sphere Extended spectrometer were calculated using the MCNP program. For incident neutrons above 10MeV, Tungsten was an excellent heavy material layer as it yielded the highest response among tested materials. As for the effect of isotopes' abundance and thickness of the metal layer, the differences in the response function could be neglected in the high-energy region (above several MeV), but the thickness of the heavy-metal layer had a considerable effect on the response. Recommended thickness for Bonner Sphere Extended spectrometers was also discussed.


The diffraction of light by a non permanent grating was first demonstrated using a grating-like structure induced by ultrasonic waves that were passed into a crystal. The invention of the laser with its extraordinary coherence then made it pos sible to use the interference between light waves to create transient gratings in various media such as solids, liquids with saturable absorption, and gases in which resonances were excited. These lightinduced gratings aroused considerable interest in various areas of laser-related research, and they eventually led to meth ods for investigating optically excited materials [1, 2].


Invited speach - The Department of Education, Ben-Gurion University of the Negev, Israel. The Lecture deals with the impact of a teacher development programme focused on the implementation of dialogic teaching practice.


Russia has always developed organically, in accordance with its own logic. If one looks at its development from the vantage point of a different culture, it may seem unnatural, even mechanical. But actually, as Mikhail Gefter noted in his time, there is an organic element to this mechanical logic.


SummaryA safe and simple method of outlining enterocoeles with methylene blue dye during vaginal operations is described. The technique has been used successfully over 10 years, and is particularly useful when the patient has previously undergone hysterectomy.


In this paper, a novel Poisson hole process (PHP) modeling of wireless networks is proposed. We consider a more general hole shape, i.e. circular sector holes in a random direction, to capture the spatial separation between tiers in a millimeter wave (mmWave) heterogeneous cellular network (HCN). In this case, small cell BSs (SBSs) and macrocell BSs (MBSs) are distributed as a PHP and Poisson point process (PPP). Due to fundamental propagation differences between mmWave and microwave frequencies, we incorporate blockage and directional beamforming in the network model. Using tools from stochastic geometry, the evaluation of the coverage performance in a two-tier mmWave HCN is provided. Since the exact formulation of distance distribution, association probability and coverage probability based on PHP modeling of SBSs is not known, fairly accurate expressions for them are derived and validated by simulation results. Moreover, some interesting facts about the effect of holes on coverage probability and the relation between proposed hole configuration and prior models with circular holes is discovered. It turns out that the analysis based on the proposed PHP model can provide a more general study than prior works and the proposed approaches are more accurate for two-tier HCNs than independent PPP-based analysis.


The scope of this paper is to explore the input parameters of a Finite Element (FE) model of an active lower limb that are most influential in determining the size and the shape of the performance envelope of the kinematics and peak contact pressure of the knee implant introduced during the Total Knee Replacement (TKR) surgery. The active lower limb FE model simulates the stair ascent and it provides a more complicated setup than the isolated TKR model which includes only the implant femoral component and the implant tibial insert. It includes bones, TKR implant, soft tissues and applied forces. The kinematics of the FE model is reported in the Grood and Suntay system, where all motion is relative to the femoral component of the TKR. Reported tibial component kinematics are tibial-femoral flexion angle, anterior-posterior displacement, and internal-external rotation, while the reported patella kinematics are patella-femoral flexion angle, medial-lateral shift and medial-lateral tilt. Tibial-femoral and patella-femoral contact pressures are also determined. Two probabilistic methods are used together with the FE model, which is termed probabilistic FE analysis, to generate performance envelopes for the reported output kinematics and peak contact pressures and to explore the input parameters: the Monte Carlo Simulation Technique (MCST) and the Response Surface Method (RSM). It is considered a large set of 77 input variables of the FE active lower limb model which have associated a Gaussian variability. Following a sensitivity analysis with the RSM, a reduced set of 22 input variables is derived, which represent the key parameters which influence the performance envelopes. It is shown that the envelopes of performance obtained with the probabilistic FE analysis using the RSM with the reduced set of 22 input variables are similar with the envelopes of performance obtained with the probabilistic FE analysis using the MCST with 800 points for the same degree of variability in the 22 input key parameters. The findings of this work are paramount to the orthopedic surgeons who may want to know the key parameters that can influence the performance of the TKR for a given human activity.


Introduction. The location of the zeros of the derivative of a polynomial has been much studied, as has the location of the zeros of the Chebys;hev polynomial. In ?1 of the present note we set forth in a direct and elementary manner the equivalence of these two problems in a suitably specialized situation. This conclusion is mentioned (for integral 'i) with an indication of the proof by Fekete and von Neumann [4],2 and the conclusion is related to a much deeper investigation due to Fekete [3]. We obtain (?9) some new results on zeros of approximating polynomials and (??2, 3, 8) on the argument of the deviation. In ?10 we consider approximation by an arbitrary linear family. Throughout the paper we study primarily approximation on a set of n points by a polynomial of degree n-2. In ??4-7 weight functions with infinities and Chebyshev rational functions are introduced.


This paper proposes a new method for implementing a low power full adder by multiplexer based Gate Diffusion Input (GDI) and Pass Transistors using 90nm and 45nm technology. Full adder is a very common example of combinational circuits and is used widely in Application Specific Integrated Circuits. It is always advantageous to have low power action for the sub components used in VLSI chips. The explored technique of realization achieves a low power high speed design for a widely used subcomponent full adder. Simulated outcome using state-of-art simulation tool shows power and speed comparison between conventional and proposed full adders also presented. All simulations have been performed on 90nm and 45nm standard models on Tanner EDA tool.


Ribonucleic acids labeled with 14C- or 3H-orotic acids, respectively were extracted from aliquots of mouse liver homogenates according to the cold-phenol-method of Kirby or the method of Georgiev employing different temperature steps. This comparative analysis showed that only ca. 50% of the total labeled RNA was extracted by the Kirby method. Especially the high molecular D-RNA and R-RNA were not sufficiently extracted, as was demonstrated by hydroxyapatite- and methylalbumin-Kieselgur column chromatography. Reextraction of the tissue at 65 °C first extracted by the Kirby method resulted in a recovery of most of the missing nucleic acid species. Therefore, results obtained by the Kirby and Georgiev methods will be different in regard to the nucleic acid composition. These findings could explain contradictary results about this problem in literature.


This essay explores how change happens in the everyday experience of individuals and how dramatic and theatrical interventions may play a part in such change processes. It seeks to overcome the historical tendency in political theatre movements towards factionalism in a desire to promote a unitary model of change or specific dramatic technique. Instead, it seeks to capture the potential of practices in drama, theatre and performance to contribute to social change by finding ways of connecting aesthetically derived experience to the lived experience of change. It seeks to restore the agency of the spectator to our thinking about how performances might be used by their audiences as individuals seek to change their societies. The focus is, then, on a pragmatic approach to political performance, concentrating on the contributions it can make in any given situation.


The use of information technologies and, in particular, information training systems increases capacity of both a teacher and a student to achieve their goals in an educational process, taking into account individual characteristics of each and providing opportunities for continuing education. The paper proposes and considers a new automated learning management system, called CATS (Care About the Students). The proposed system covers all components of the educational process, allows to conduct an electronic journal of visiting and defending laboratory works, distribute topics and monitor progress of course and diploma projects (creating automatically task sheets with subsequent export to MS Word editor). The CATS LMS makes it possible to test students' knowledge in control and self-education modes, to form electronic educational and methodical complexes, to inform students about topics of lecture and practical classes with the possibility of downloading relevant materials, to provide educational content in SCORM format, developed by teachers around the world. Working in the CATS system, it is possible to exchange messages with students and teachers, to monitor progress and process of studying in respect of the proposed material by students, to check accomplished assignments of students for plagiarism. The system under consideration also takes into account specificity of training at a technical higher education institution, providing for work with an integrated project management system and ability to submit bugs. The CATS LMS has been implemented as a web application using modern technologies and it is available in the local network within the whole university at [172.16.11.72:2020].


SYNOPSIS

Two species described by Bagnall on damaged uniques are redescribed from fresh material of both sexes: roboris, belonging in the Trypoctothrips complex. and frontalis, which belongs with three other Australasian species in a group of genera involving a parallel phyletic line referred to here as the Dinurofhrips complex. Two new genera are defined, one from Australia and one from Brazil; five new species are described, two Australian, two Nigerian and one Brazilian; four new synonymies are indicated from Australia and one from Nigeria; host records are given for two little known species.


Les eglises de la Moldavie du nord : architecture et peinture. By PAUL HENRY. Pp3 ' 3 ; 68 plates. Paris: Leroux, 1930. The famous churches of the Bukovina have long awaited scholarly publication. Their unique architectural and pictorial qualities have been long recognised, but hitherto never studied. Now the full information concerning not only the particular group of externally decorated churches, but the whole series, is set forth by M. Henry in a finely illustrated monograph. The author shows how the art of Moldavia had a strictly Byzantine but not an ancient origin. What makes both the architecture and the painting of this region so important is that there is discernible in both an element first of Gothic and then of French Renaissance, imported into a Byzantine world probably by way of Hungary, where French architects and artists were active from as early as the thirteenth century. The architecture which was born in Moldavia in the time of Stephen the Great was Byzantine in essence, Occidental in detail. Rumanian church-building thus stands out as one of the most distinguished versions of the Byzantine in Europe. The subtlety with which the Gothic elements are incorporated is astonishing, particularly during the period 1487-149,7.


Oysters from a harvesting area responsible for outbreaks of gastroenteritis were relaid at a clean seawater site and subsequently depurated in tanks of purified seawater at elevated temperatures. This combined treatment reduced norovirus levels to those detected prior to the outbreak. On the basis of norovirus monitoring the sale of treated oysters was permitted although the harvest area remained closed for direct sale of oysters. No reports of illness have been associated with the consumption of treated oysters.


A novel design of printed monopole antenna for the ultra‐wideband (UWB) applications with band notch characteristics at wireless local area network (WLAN) and X‐band satellite communication system has been proposed in this manuscript. Two different types of feed lines, that is, simple and tapered are used to excite the proposed antenna. Initially, designed antenna is excited by using simple 50 Ω transmission line after that tapered transmission line is introduced to enhance the impedance matching throughout the UWB frequency range (3.1‐10.6 GHz). A comparison of designed antenna with simple and tapered feed line on the basis of impedance matching has also been made in this article, and found that later case reports better impedance matching in terms of Voltage Standing Wave Ratio (VSWR) bandwidth (2.45‐12.0 GHz). Further, the notch bands are embodied into the designed antenna by using two split ring slots and one horizontal slot. The antenna with outer ring slot rejects the WLAN frequency band and antenna with inner ring junks the X‐band satellite communication signal. The notch frequency has been adjusted by optimizing the dimensions of split ring slots as well as horizontal slot, which are incised on the structure of proposed antenna. By adjusting all the parameters of the etched slots of proposed antenna, dual band notched characteristics centered at frequencies 5.4 and 7.4 GHz has been achieved. Designed antenna is also compact (30 × 30 mm2) and capable to suppress the interference of WLAN and X‐band satellite communication signal from the entire range of UWB passband. The proposed antenna is designed on low cost FR4 glass epoxy substrate with 1.6 mm thickness and dielectric constant 4.4. Antenna is designed and simulated by using HFSS V13 simulator and further, it is fabricated and tested for the validation of results. Simulated and measured results are also juxtaposed and found in good agreement with each other.


As a social phenomenon, disability has always been rampant in societies so that it has always been considered as an essential problem in terms of the social relations. There have not been constant relations between social and scientific development on one hand and the social status of the amputees on the other hand [1]. As impairment appears and disability symptoms unfold, the amputees lose their self-reliance and the sense of dependence on others grows in them. Decreased self-confidence, developing a negative personality, a sense of incompetence and encumbrance affect the remaining resources in the amputees and induce a feeling of desperation and confusion in them. Recent findings shows that physical exercise helps improve both physical and mental conditions in the disabled through improving mental conditions including emotional states and self-knowledge [1-3]. The emotional spirit pervading a family prompts the family members to help the disabled with their personal activities despite their preference for independence. This causes an internal sense of embarrassment and nurtures a sense of reliance on others in them. Therefore, the disabled lose their selfconfidence gradually and tend to be isolated, indecisive and disillusioned [1, 2].As the health or impairment Abstract:


THE field of endrocrinology,more especially that of the sex hormones,has becomewider and wider. Its divergence makes it impossible to keep pace with its rapid progress. This is made most difficult 'for the clinician, as he is endlessly struggling to keep his head above an everincreasing heap formed of pamphlets thrown at him by the manufacturing chemists, and of small, fragmentary, hurriedly published papers showered upon him by biochemical and biological researchworkers. If he does . manage to emerge, instead of being able to breathe the pure air of understanding,as likely as not he finds himself in a smokescreenof faulty observation and inaccurate , deductionsproducedby his well-meaningclinical brethren. It is little wonder,that at times he becomesunreasonable and reckless. Neverthelessall the time new facts are emerging which are gradually correlated to provide a picture of the true endocrine scheme. Tonight I have assumedthat, in the conditionsdiscussed, all causesother than endocrineones have been systematically excluded,and we are left with none but disturbances of sex hormoneequilibrium. It will be of assistanceto make the briefest surveyor our knowledge of the endocrine system as it affects the endometrium. The anterior pituttary is looked upon as the controlling body; but it is probablethat it is influenced from above perhaps by the hypothalamus. This is particularly shown in amenorrhoea,in which, we are all aware, psychogenicfactors often playa not inconsiderable part, operating either through the higher centres or by autonomic control. The anterior lobe of the pituitary produces the following hormonic stimuli: gonadotropic, thyreotropic, adrenotropic, lactogenic, growth, parathyreotropic, pancreatic, diabetogenic and ketogenic. They normally all act in harmony. The gonadotropichormones control ovarian periodicity. Prolan A inducesovulation and maturation,and prolan B induces direct luteinization of the follicles even without ruptureand ovulation. The ovariesin turn directly control the condition of the uterusduring the cycle. <Estrin is produced in increasing amounts during the pre-ovulatoryor proliferative phaseas well as during the post-ovulatory or secretory phase. With rupture of the follicle about the thirteenth day there is a sudden and temporary drop in the level of restrin. Progesteroneis producedonly after ovulation. The amountsincreasetill a day or so before the end of the cycle. <Estrin is responsiblefor the developmentand growth of the genital tract and for its maintenanceat that stageof development. It causesproliferation of the endometriumand inhibits the anteriorpituitary. Further,it counteractsprogesterone, but is synergisticwith it, preparing the uterus for the action of the luteal hormone. Progesteronechanges the proliferative phase of the ondometrtumto the secretoryphase. It counteractseestrtn and may delay ovulation. Progesteroneis excreted as pregnandiol. The substancepregnandiol,which is similar


The value of expression is meaning and communication. Meaning is the judgment of designers inferred from consumer memories of the subject and communication is the judgment of consumers regarding the judgment of designers. The value of expression is determined by the judgments of designers and consumers so there is a strategically mutual dependence between designers and consumers. Therefore, this study aims to apply game theory to design acts in which strategically mutual dependence exist to explore the success rate of predictable expression. This study put mathematical probabilities calculated based on the subject of case numbers into a 2 × 2 game model to estimate the success rate of expression. The results were as follows. Regarding designer expressions with a positive and negative probability of 0.5, there is ① a 0.25 probability that the consumer will make a positive judgment ② a 0.25 probability that the consumer will make a negative judgment and ③ a 0.5 probability that the consumer will make either a positive or negative judgment. Success rates calculated by putting the probabilities of ①②③ into a 2 × 2 game model were as follows. The success rates of ①② are 31.25%. The success rate of ③ is 25%. The success rates of 31.25% and 25% are cases in which designers have 50% certainty in their own design. When designers have 100% certainty in their own design, success rates are 62.5% and 50%. It can be assumed that when designers have a 50% certainty in their own design, they have emphasized efficiency and universality and when they have a 100% certainty in their own design, they have emphasized originality and an experimental nature. In the zero sum game, because consumers do not choose as much as the success rate, it must be predicted that designers fail that much. In designs, it can be assumed that because efficiency and universality are emphasized from consumer perspectives, they deal with failure rates and because originality and experimental nature are emphasized from designer perspectives, they deal with success rates. This is because designs simultaneously pursue low failure rates and high success rates. Designers are required to scientifically analyze the demands and needs of consumers within social, economic, and cultural contexts, acquire design efficiency and universality, and to pursue experimental nature within descriptive contexts and originality within aesthetic contexts. Efficiency and universality are necessary conditions for design and experimental nature and originality are sufficient conditions.


In recent years, career guidance has been recognized as an important part in implementing lifelong learning strategies, as a means to achieve economic and political goals in European countries. Car ...


Rob Cramb and John F. McCarthy, eds. The Oil Palm Complex: Smallholders, Agribusiness and the State in Indonesia and Malaysia. Singapore: NUS Press, 2016, xvi+470pp. Author(s) Terauchi, Daisuke Citation Southeast Asian Studies (2017), 6(2): 393-397 Issue Date 2017-08 URL http://hdl.handle.net/2433/226958 Right © Center for Southeast Asian Studies, Kyoto University Type Departmental Bulletin Paper Textversion publisher


Summary B cells are critical for adaptive immunity and are governed by the recognition of an antigen by the B cell receptor (BCR), a process that drives a coordinated series of signaling events and modulation of various transcriptional programs. Single-cell RNA sequencing with paired BCR profiling could offer insights into numerous physiological and pathological processes. However, unlike the plethora of single-cell RNA analysis pipelines, computational tools that utilize single-cell BCR sequences for further analyses are not yet well developed. Here we report Ibex, which vectorizes the amino acid sequence of the complementarity-determining region 3 (cdr3) of the immunoglobulin heavy and light chains, allowing for unbiased dimensional reduction of B cells using their BCR repertoire. Ibex is implemented as an R package with integration into both the Seurat and Single-Cell Experiment framework, enabling the incorporation of this new analytic tool into many single-cell sequencing analytic workflows and multimodal experiments. Availability and Implementation Ibex is available as an R package at https://github.com/ncborcherding/Ibex. Reproducible code and data for the figure appearing in the manuscript are available at https://github.com/ncborcherding/Ibex.manuscript. A companion TCR-based approach is available at https://github.com/ncborcherding/Trex.


Thermally stimulated creep recovery (TSCR) experiments have been used to study the influence of tacticity on the α retardation process in amorphous poly(methyl methacrylate) (PMMA). The α retardation process associated with the glass transition is strongly dependent on tacticity. The high-sensitivity TSCR−fractional loading (FL) method was used to extract the distributions of activation enthalpies ΔH and entropies ΔS of the α mechanical relaxation. ΔH increases with temperature and is maximum at the glass transition temperature Tg. The maximum value and the full width at half-height of the activation enthalpy distribution are tacticity-dependent. Comparing experimental activation enthalpies with Starkweather's zero entropy prediction shows that the low-temperature tail of the α retardation process extends to 30 °C independent of tacticity. This result is attributed to the presence of isotriad sequences enhancing molecular mobility in this temperature range.


Objective To investigate the inhibitory effects of norcantharidin (NCTD) on angio- genesis of human gallbladder carcinomas,growth of human HUVEC in vitro,for the capillary vessels of chick CAM in vivo and for angiogenesis of the implanted tumors of human gallbladder carcinomas in nude mice in vivo.Methods Human umbilical vein endothelial cells (UVECs) model by cell culture and CD34 dye identification using SABC method,chick CAM model of new angiogenesis by incubation of chick eggs and the implanted tumor model by subcutaneous implantation of cultured GBC-SD cells into nude mice were respectively established in vitro and in vivo.The ED_(50) of NCTD for HUVECs was measured.The HUVECs experiment,CAM experiment and the nude mice experiments were respectively done.The mor- phology and percentage of HUVEC apoptosis in each group in the HUVEC experiments were evaluated by Hoechst 33258 immunofluorescence method and fluorescent microscopy.The inhibitory and destroy ef- fects on the capillary vessels of chick CAM among different groups were observed and compared by well- differentiate digital camera.Tumor dimension, morphological change of microvessel invasion and destruc- tion around tumor,MVD of implanted tumors were respectively evaluated. MVD and cell apoptosis of im- planted tumors were respectively determined by CD34 immunohistochemistry (SABC method) and FCM.Results (1) ED_(50) of NCTD for HUVECs in vitro was 0.352 g/L.The percentage of HUVEC apoptosis induced by NCTD was respectively higher than that of control group [(76.86±5.67)% vs 4.60±1.45)%;P<0.05] and there was no significant difference among NCTD,endostatin and NCTD + endostatin groups.The morphological changes of cell apoptosis in above three groups were observed un- der fluorescent microscopy.It was deduced that NCTD can effectively inhibit the growth of HUVEC by inducement of HUVEC apoptosis in a dose and time dependent manner.(2) In CAM experiments,with the increased dose (2.5-5.0 g/L) of NCTD,the survival rate of chicken eggs in NCTD groups was sig- nificantly decreased (55 %-60 % vs 80 %,P<0.05),the capillary vessels of chick CAM were reduced, while the inhibitory rate of chick CAM angiogenesis was significantly increased as compared with the con- trol group (90.9%-100.0% vs 0, P<0.05) and the low-dose NCTD groups (25.0%-53.3%,P<0.05);There was no difference in the survival of chicken eggs and the angiogenesis inhibition of chick CAM between tth NCTD group and endostatin group (P>0.05).There was a positive correlation be- tween the anti-angiogenesis of chick CAM and the dose of NCTD (r= 0.89,t=3. 450,P<0.05).It was deduced that NCTD can effectively inhibit angiogenesis and directly destroy the formed capillary ves- sels of chick CAM in a dose dependent manner.(3) After treatment of NCTD,MVD in NCTD group was significantly decreased as compared with the 5-Fu group (4.12±1.40 vs 15.80±5.90,P<0.01) and the control group (4.12±1.40 vs 17.60±3.20, P<0.01),without difference in comparison to endo- statin group (P>0.05).Invasion,damage or destruction of microvessels around tumor with apoptosis and necrosis were observed.There was a positive correlation between MVD and volume of implanted tumors (r=0.985,t=8.069,P<0.05),and PCNA/apoptosis ratio of implanted tumor cells (r=0.956,t= 4.610,P<0.05).It was deduced that NCTD inhibit proliferation and growth of the implanted tumors by inhibition of the implanted tumor angiogenesis.Conclusion NCTD can effectively inhibit the angio- genesis of gallbladder carcinomas,further inhibits their growth.


Energy shortage and environmental pollution mainly caused the global energy crisis which led to serious impact on human survival and development. Microbial fuel cells (MFCs) exactly meet the requirements to alleviate the global energy crisis because it has the ability to treat the wastewater and produce electricity concurrently. MFCs are considered as one of the promising technology in the wastewater treatment technology. The power output depends on various factors such as substrate degradation, electrode material, rate of electron transfer from bacteria to the anode, circuit resistance, proton mass transfer in the liquid, external operating conditions and so on. Electrode material is one of the key factors which affect the performance of MFC. Therefore, it is of great significance to select and develop suitable electrode materials to optimize and promote the performance of MFCs. Each electrode material has its own physical and chemical properties such as surface area, electric conductivity and chemical stability. In this research, we have tested two different electrode materials such as; polyacrlyonitrile carbon felt (PACF) and single forward carbon cloth (SFCC) to study the effects of different electrode materials on MFC performance. The results showed that MFC with SFCC using raw POME showed high power density (102.5mW/m2) compared to PACF (45mW/m2). But COD removal efficiency with raw POME of SFCC (43%) and PACF (45%) were not shown much difference. The coulombic efficiency of 1:50 diluted POME reached upto 26% for SFCC whereas for PACF 24% was achieved. SFCC achieved the highest coulombic efficiency and power output than PACF, indicating SFCC facilitate the biofilm formation and improve power generation.


Several two-dimensional analytical beam column joint models with varying complexities have
been proposed in quantifying joint flexibility during seismic vulnerability assessment of non-ductile
reinforced concrete (RC) frames. Notable models are the single component rotational spring element and the
super element joint model that can effectively capture the governing inelastic mechanisms under severe
ground motions. Even though both models have been extensively calibrated and verified using quasi-static
test of joint sub-assemblages, a comparative study of the inelastic seismic responses under nonlinear time
history analysis (NTHA) of RC frames has not been thoroughly evaluated. This study employs three
hypothetical case study RC frames subjected to increasing ground motion intensities to study their inherent
variations. Results indicate that the super element joint model overestimates the transient drift ratio at the
first story and becomes highly un-conservative by under-predicting the drift ratios at the roof level when
compared to the single-component model and the conventional rigid joint assumption. In addition, between
these story levels, a decline in the drift ratios is observed as the story level increased. However, from this
limited study, there is no consistent evidence to suggest that care should be taken in selecting either a single
or multi component joint model for seismic risk assessment of buildings when a global demand measure
such as maximum inter-storey drift is employed in the seismic assessment framework.


Introduced American grey squirrels have replaced native red squirrels in most of the range currently occupied in Britain and northern Italy. The mechanisms of the replacement are not yet fully understood. We restated the commonly cited Interference Competition Hypothesis (ICH) that grey squirrels interfere with the behaviour of red squirrels in three possible ways: 1. by direct aggressive interactions; 2. by interrupting red squirrel mating-chases; or 3. by forcing red squirrels to actively avoid areas intensively used by grey squirrels. We compared the activity pattern, behaviour and reproductive performance of red squirrels in two study areas in northern Italy, one with only red squirrels (control area C1), the other with both species (experimental area E1). The following predictions were tested: 1. the total time spent in both intraspecific and interspecific interactions by red squirrels increases in the experimental area; 2. most interspecific interactions are aggressive, with grey squirrels being the dominant species; 3. the proportion of breeding female red squirrels that are unsuccessful at weaning offspring increases in area E1; 4. grey squirrels take part and interfere with red squirrel mating-chases, and thereby decrease the reproductive output of red squirrel females; 5. the activity pattern of red squirrels in the mixed-species area is shifted with respect to that in the control area to the hours of the day during which grey squirrels show little activity; and 6. red squirrels will shift their home range (or at least their core-area) when grey squirrel densities increase to avoid interspecific core-area overlap.

Our results supported only the first prediction of the ICH: they failed to support all the other predictions. Moreover, the increase in the percentage of active time red squirrels spent interacting with other squirrels in the experimental study area was very small (only 1–2 min/day). Red squirrels did not avoid the woodland patches most intensively used by grey squirrels and the interspecific core-area overlap was similar to red squirrel intraspecific core-area overlap. This suggested that red squirrels avoided spatial overlap with grey squirrels in a similar manner as with conspecifics and that an increase in grey squirrel numbers will augment the intensity of resource competition. We therefore conclude that our results do not lend support to the Interference Competition Hypothesis and that interference competition by grey squirrels cannot explain the large-scale replacement of red by grey squirrels that has occurred in Britain and in Piedmont.


Functionalized composite SWCNT is a promising material for scalable production of portable gas sensors. To fully exploit their potential, these gas sensors need a faster recovery rate and higher sensitivity at room temperature than the bare SWCNT based gas sensor. Here we present in this paper with a chemiresistive gas sensor based on HFIP derivative hybrid using functionalized SWCNT, capable of sensing < 5 ppm of NO2 at room temperature. I test the sample both in vacuum and in air and observed an exceptional improvement in the performance compared to bare SWCNT based gas sensor. In particular, the recovery time for sensing NO2 at room temperature is more than one order of magnitude faster than a bare SWCNT based gas sensor. The sensor shows an unique combination of high sensitivity and fast recovery time, matching    the requirement on materials expected to foster widespread use of portable and affordable gas sensors.   .


In our recent Policy Forum "Waiting for organ transplantation" (14 Jan., p. [237][1]), we reported findings of the Institute of Medicine (IOM) study of Organ Procurement and Transplantation ([1][2]), including the finding that Organ Procurement Organizations (OPOs) ([2][3]) serving smaller


INTRODUCTION
Current research estimates that over 24 million individuals experience human trafficking worldwide. There is a growing prevalence of sex trafficking in the United States. An estimated 87% of trafficked persons visit the emergency department during their captivity. Emergency departments across the United States use differing screening methods for sex trafficking. Current screening tools return a high rate of false negatives, and the appropriate use of tools or standardised lists remains unclear.

AIMS
To explore best practices for identifying sex trafficking among adults who visit emergency departments. We sought to answer the practice question: How does the implementation of a multifaceted screening model for sex trafficking, versus the use of a list of standardised screening questions, improve the detection of trafficked persons?

METHODS
We conducted an integrative review of articles published after 2016 in PubMed, CINAHL, Embase, SCOPUS, and Web of Science databases. PRISMA checklist and guidelines were used. Whittemore and Knafl's method was used to review the literature.

RESULTS
A final selection of 11 articles were reviewed and appraised using the Johns Hopkins nursing evidence-based practice model. The synthesis of evidence yielded four themes: (1) Provider and personnel education; (2) Protocol establishment; (3) Legal consultation; and (4) Multidisciplinary teamwork.

CONCLUSION
Through this process, we learned the importance of using multifaceted screening tools for identifying persons who are experiencing sex trafficking. In addition to using multifaceted screening tools, detection is improved when all emergency department personnel receive training on sex trafficking. There is a recognised lack of education on sex trafficking recognition nationwide.

RELEVANCE TO CLINICAL PRACTICE
Notably, emergency department nurses play an essential role in sex trafficking identification due to their maximised interaction with patients and the increased perception of trust that patients have with nurses. Steps include the development of an education program to improve recognition.

NO PATIENT OR PUBLIC CONTRIBUTION
There was no patient or public involvement in the design or drafting of this integrative review.


At the extreme conditions expected for some operating scenarios of the International Thermonuclear Experimental Reactor, commonly used heat‐removal structures are unable to withstand either the high sputter erosion rates or power loads. Solutions to these lifetime and reliability problems by (1) changes in machine design and operation, (2) redeposition mechanisms, and (3) changes in materials, will be discussed. A proposed accelerated‐life test facility for prototype divertor plate development is described.


It is a well-known fact that Dirac phenomenology of nuclear forces predicts the existence of large scalar and vector mean fields in matter. To analyze the relativistic self-energy in a model independent way, modern high-precision nucleon-nucleon (NN) potentials are mapped on a relativistic operator basis using projection techniques. Comparison of the various potentials at the level of covariant amplitudes produced remarkable agreement. It allows further calculation of the relativistic self-energy in nuclear matter in the Hartree-Fock approximation. Independent of the choice of the nucleon-nucleon interaction large scalar and vector mean fields of several hundred MeV magnitude are generated at tree level. In the framework of chiral effective field theory, these fields are dominantly generated by contact terms that occur at next-to-leading order in the chiral expansion. Consistent with Dirac phenomenology the corresponding low-energy constants that generate the large fields are closely connected to the spin-orbit interaction in NN scattering. The connection to quantum chromodynamics sum rules is discussed as well.


Stock return is the value obtained as a result of investment activities. The expected return is in the form of dividends for stock investments and interest income for investments in debt securities. The existence of a fairly high stock return will attract more investors to buy the stock. The purpose of this study was to determine the effect of liquidity on stock returns through profitability as an intervening variable in technology companies listed on the Stock Exchange for the period 2016-2022. The method used in this study is a descriptive and quantitative method. The population of this study are technology companies listed on the Indonesia Stock Exchange. The sampling technique was determined by purposive sampling method.
The results of the direct influence hypothesis test using the Smart PLS 3.0 application, show that liquidity has a positive but not significant effect on profitability, liquidity has a significant negative effect on stock returns, profitability has a positive significant effect on stock returns, liquidity has a positive but not significant effect on stock returns through profitability.


Lauren Scharff firstname.lastname@example.com Albert Ahumada email@example.com) U. S. Air Force Academy Introduction Scharff and Ahumada (2002, 2003abc) measured text legibility for light text and dark text. For paragraph scanning and letter identification, performance was better for dark text than light text when we equate Weber contrast (the difference between text and background luminance divided by the background luminance). In recent studies with better stimulus control (Scharff & Ahumada, 2005; 2008), we continued to find a small, but consistent benefit of dark text for letter identification. Reading involves both scanning and identification. In the experiments below we replicate our scanning result with our improved apparatus and add scanning to our letter identification task by manipulating eccentricity.