Introduction
The gap between current undergraduate medical curriculum and eHealth and clinical informatics in health care contexts has been clearly identified in the literature. eHealth requires a fundamental change to the design and delivery of the medical curriculum to ameliorate forecasted shortages in the digital medical workforce. Yet a mismatch between the current undergraduate medical education curriculum and practice reality have not been satisfactorily addressed. This work describes outcomes from the delivery of an innovative eHealth informatics elective, which was designed to embed health informatics, a disruptive pedagogical concern, into undergraduate medical education.
Method
This single case study uses an action research approach to draw on the process of progressive problem solving that improves educational approaches to eHealth informatics in undergraduate medical education settings. The study shares key aspects of our learning with others involved in eHealth training to support similar informatics innovations for consideration in the future design of undergraduate medical curriculum.
Results
We analyze lessons learned from the design and delivery of a creative eHealth elective for first year medical undergraduate students at Monash University (Australia). We needed to overcome seven key challenges "on the run" to help prepare the students for digital practice horizons. Firstly, a lack of suitable funding and resources hampered elective design. Medical students enrolling in the elective were overwhelming male and lacked techno-savvy in the context of medical practice and learning. Medical students were unaware of the risks, benefits and security threats relating to the application of eHealth systems in practice. Only a very limited number of academic staff possessed the specific skills required to achieve informatics learning outcomes. Specific skills training were required for most students enrolled in the elective. Finally, we needed to ensure the transparency of medical and eHealth informatics jargon to support student learning.
Discussion
The design and delivery of this elective allowed the education content around serious computer games and applications for eHealth to be embedded into the medical pedagogy. Direct and collegiate support was a critical element in the successful development of the program. The program did not require additional space in an already busy curriculum. Student feedback suggested gender imbalances in the class may have been addressed by improved communication. The evidence also indicates noteworthy mismatches between the perceptions of course designers and the expectations and skill level of students. Academic staff required robust eHealth informatics, information privacy, and security teaching skills to lead the elective. In addition, significant resource constraints became apparent requiring flexibility and the capacity to modify the program during delivery. Nonetheless the elective provided a space for students to reflect upon their own learning in eHealth informatics. Experience in design and delivery of this elective has informed content for knowledge management, which is a core component of the current undergraduate medicine curriculum at our institution. []


The effect of the character of Absorbing water was studied in Japanese leafbud rockress:the different temperature.The results indicated that the leafbud rockress seeds have the biological character of Absorbing water rapidly.At 10~25℃,put the seeds into water,after 3 hours,the seeds weight will be 83.1% and 84.3% as itself,after 17 hours,the seeds weight will be 157.2% and 164.1%.Temperature has no signficant on the rate of Absorbing water.The strength of illumination has little influence on the sprout.


Abstract α s1 -Casein has been observed to differ from α s1 -B by its solubility in CaCl 2 solutions at 1 and 37C, and by its stabilization profile in the presence of κ-casein and calcium ions. The different characteristics of the protein α s1 -A have been attributed to the deletion of a segment of nonpolar amino acids resulting in decreased hydrophobic interactions among α s1 -A molecules. The deletion also has impaired the formation of α s1 -κ-casein micelles under conditions of normal formation.


These proceedings collect papers on the subject of stress analysis. Topics include: piping and pressure vessel analysis, prediction of creep damage locations in high energy piping systems, life extension analysis, pressurized gaseous storage vessels, damage evaluation of steels, fluid-structure interactions, and structural integrity of containment vessels for BWR type reactors.


In many objectives and contents of volleyball unit teaching,changing the traditional and single educational methods,many kinds of educational methods were composed and optimized into the volleyball teaching classroom according to the teaching speed of progress and teaching unit or teaching task.Experiments prove that many kinds of teaching method,which are integrated,optimized and combination application to the volleyball teaching,can improve teaching effect and quality.


Objective To investigate the rescue regimens after failed of Helicobacter pylori (HP )eradication with standard triple therapy. Methods Ninety-five patients who infected HP with triple therapy(PPI+amoxicillin+clarithromycin)failed were random devided into trial group(PPI+ levofloxacin+amoxicillin) and control group (quadruple therapy),then the rate of HP eradication was evaluated,the adverce reaction was evaluated after the end of treatment .Results Trial group was better than control group in rate of HP eradication ,trial group was less than control group in adverse reaction.Conclusion After HP eradication failure, levofloxacin-based rescue regimen is more effective and tolerated better than the generally recommended quadruple therapy.


Compost application to turfgrasses may contribute to accumulation of macro- nutrients in soil and eventually pose leaching and runoff hazards. The objectives of this study were to determine the influence of compost on soil-dissolved organic C (DOC) and accumulation of NH4OAc-EDTA-extractable and water-soluble nitrogen (N), phospho- rus (P), potassium (K), calcium (Ca), magnesium (Mg), and sulfur (S) in St. Augustine- grass (Stenotaphrum secundatum (Walt.) Kuntze) turf. Dissolved organic C increased from 3 to 29 months after application for unamended and compost-amended soils, indicating contribution from decomposition of both compost and St. Augustinegrass residues. Dissolved organic C was 75%, 78%, and 101% greater 29 months after application of 0, 80, and 160 mgha -1 of compost, respectively, than before application. Dissolved organic C and macronutrients exhibited considerable seasonal variation, because DOC and EDTA-extractable P, Ca, Mg, and S increased after compost application, whereas NO3 declined. Water-soluble K, Ca, and Mg declined, whereas P and S increased from 0 to 29 months. Similar seasonal changes in macronutrient concentrations occurred for unamended and compost-amended soil, indicating that composts, in addition to turfgrass residues, influenced DOC and macronutrient dynamics. Long-term nutrient accumulation occurred in compost-amended turfgrass, but seasonal dynamics were more related to the growth stage of turfgrass than compost. Formation of DOC-cation complexes appeared to contribute to macronutrient mobility, because decreases in DOC and nutrient concentrations occurred during turfgrass dormancy in winter and after high precipitation levels, indicating the potential for leaching of DOC-associated nutrients from soil.


The prevention and control effects of biological and chemical pesticides were studied using the spray and leaf dipping methods to effectively prevent and control Ectropis oblique hypulina,Orthaga achatina,Micromelalopha troglodyte and Latoia consocia in the forests of Chongming County. The results showed that the prevention and control effects of biological pesticides were slower than but as good as that of chemical pesticides. 250 g·kg-1 benzoylphenal urea Ⅲ were ideal pesticides for Ectropis oblique hypulina and Orthaga achatina. 10 g·kg-1avermectin and 200 g·kg-1 diflubenzuron had very good prevention and control effects on Micromelalopha troglodyte and Latoia consocia respectively. Through this research,we selected 5 new biological pesticides for the forestry of Chongming County,namely,250g·kg-1 benzoylphenal urea Ⅲ,Bt suspension concentrate,10 g·kg-1 avermectin,200 g·kg-1 diflubenzuron and 50 g·kg-1 chlorfluazuron EC,which were of high efficiency,low toxicity and low residues. [Ch,4 tab. 16 ref.]


It is known that the fundamental mode of rotation in quantum fluids is represented by a quantum vortex. Its quantized value represents the orbital angular momentum (OAM) per particle, which is reduced in case of offset vortices. Here, we study analytically the dynamics of a displaced quantum vortex in a number of 2D systems, including infinite or harmonic confining potentials and a two-component condensate. The vortex core demonstrates peculiar motion in all such systems, however, the OAM content may vary in time or not, depending on the underlying physics. For the off-axis vortex in the radial potentials, the OAM remains invariant, despite the core moves on circular or elliptic orbits and even when secondary vortex-antivortex pairs proliferate due to self-interference of the wavepacket being reshaped. However, including harmonic time perturbations with a gain-dissipation term or adding a spatial anisotropy, confers time-varying OAM to the morphology reshaping. Considering a binary condensate, the Rabi dynamics can imply time-dependent angular momentum and core orbital motion in each of the components, as a natural result of their coherent coupling. The salient result across all the different cases is that a weird motion of the vortex core, and also its dynamical morphology, are distinct from and do not necessarily imply a time-varying OAM per particle, whereas the latter always imply some offset core and its morphology reshaping.


Hierarchy of small drainage basins, conditions and factors of their forming, and typical processes on every hierarchic level are examined. The following spatiotemporal hierarchic levels have been distinguished: 1) slopes and bottoms of small drainage basins; 2) elementary basins; 3) single small drainage basins; 4) regional types of small drainage basins. Compiled spatiotemporal matrix shows how objects of investigation are distributed in accordance to their hierarchy. Every hierarchic level has its own complex of processes. Present day level deals with segments of small drainage basins, which are exposed to weather conditions. Anthropogenic activity reaches its maximum importance on the historical interval. Level of geological time intervals deals with great regional units, where climatic and tectonic conditions, rock features, etc are the most important factors. As a result, the necessity for selecting particular methods for every hierarchic level during investigation of small drainage basins is shown.


The authors consider the problem of propagation of nonlinear waves through photorefractive crystals in which a nonlinear response is induced by a drift mechanism. This problem is used as an example to formulate an algorithm for constructing a new class of stable self-consistent periodic solutions, which are multicomponent photorefractive cnoidal waves. Explicit exact analytic expressions are derived for the distributions of the optical field in terms of parts of such solutions containing up to three mutually incoherent components of the optical field. It is shown that, in a fairly wide range of the spatial period, such cnoidal waves are stable and that their spatial structure is conserved in collisions of the waves with one another and in the presence of stochastic perturbations of the distributions of the field intensities of the components.


The induction of a helicoidal smectic A (SmA*) phase in binary polymorphic systems including the achiral mesogen p-(n-hexyl) oxyphenyl ether p-(n-octyl) oxybenzoic acid and the chiral smectogen A N-[4-(n-nonylphenyl)benzoyloxy] benzylidene-S-1-benzylethylamine is demonstrated. Induction of SmA*- and N*-phases is observed at small (∼ 1 mole %) concentrations of the chiral component along with an increase in the SmC* → SmA* phase-transition temperature compared to that of the SmC → N transition of the starting achiral mesogen and a decrease in the angle of inclination of the molecules in the SmC* layers


Along with the fact that knowledge is becoming the key recourse for affecting the operating efficiency of whole supply chain,the academicians and enterprises gradually pay attention to the problems on knowledge management(KM) in supply chain(SC).It gives a detailed review on the researches of KM in SC from following aspects: the meaning of KM in SC,the hotspot problems of KM in SC,the implementation of KM in SC,the relationship between KM and the performance of SC.In the purpose of summarizing the related scope of researches in this field,it puts forward some suggestions for enterprises practice.


Objectives: To characterize protein molecular structure using Fourier Transform Infrared Spectroscopy (FTIR) with univariate and multivariate molecular spectral analysis and identify the structure differences among barley cultivars. Place and Duration of Study: Six barley cultivars: (1) cv. Yousef, (2) cv. Nosrat, (3) cv. CB.79.10, (4) cv. Makooie, (5) cv. Abidar, and (6) cv. Sararood were provided from Crop Development Center Karaj, Iran. FTIR spectroscopy was carried out at the University of Saskatchewan (Saskatoon, Canada), between May 2012 to November 2012. Methodology: The spectral data were collected from feeds using JASCO FTIR-ATR-4200. The molecular structure spectral analyses involved protein amide I, amide II, α-helix, βsheet, total carbohydrate, the ratio of amide I to amide II, α-helix to β-sheet, and starch to amide I. Results: Molecular spectral techniques were able to identify spectral differences associated with the molecular structural differences among barley cultivars. It was found that protein molecular structure in terms of amide II, the ratio of amides I to II and the ratio Research Article Annual Research & Review in Biology, 4(1): 258-268, 2014 259 of αhelix to β-sheet significantly differed among cultivars. Makooie had the greatest peak area and height amide II and the ratio of α-helix to β-sheet. It had the lowest ratio of amide I to amide II and the ratio of starch to amide I. Carbohydrate molecular spectral intensities were also varied among barley cultivars, but it was not statistically significant. CB.79.10 had the greatest peak area CHO. The infrared absorbance intensity ratio of starch to amide I was different among barley cultivars. It was higher for CB.79.10 indicating that CB.79.10 is more heterogeneous than those of other barley cultivars. Conclusion: The biological function differences between barley cultivars may be related to molecular structure difference and biopolymer conformation between the cultivars of barley. Further study is needed to quantify protein and carbohydrate related molecular spectral features of barley in relation to nutrient supply and availability of protein and carbohydrate.


Current algorithmes on multiagent learning are for almost limited since they cannot manage the multiplicity of Nash equilibria and thus converge to the Pareto-optimal. To alleviate this, we propose here a learning mechanism extending the Q-learning to non-cooperative stochastique games. This learning mechanism converges to Pareto-optimal equilibria in self-play. We present experimental results showing convergence of such learning mechanism. We then extend our approach to the case of non-stationarity of agents which is another important aspect of multiagent systems. Finally, we tackle the question of non stationarity in multiagent environments in its generality and we present in this context some research avenues which can lead to improve our preliminary results on adaptation.


Abstract Reliable surveillance of urban networks coupled with techniques for information acquisition on traffic states provides the basis for the deployment of Advanced Transportation Management and Information Systems (ATMIS). Since information can be collected from various sources, a gamut of approaches for the fusion of available data has been utilized in traffic control centers. This paper focuses on a special paradigm of data fusion that combines information on forecasted traffic volume obtained from a variety of alternative approaches and provides a novel forecasting scheme that treats uncertainty by adopting concepts from fuzzy set theory and expert knowledge.


ABSTRACT Sixteen accessions of sweet basil obtained from different parts of India were studied for qualitative and quantitative characters. The highest oil percent in green herbage, essential oil yield, and anethole yield were recorded in DOB-1 at full bloom stage. DOB-1 leaves had the highest number of peltate glands (PG) at all three stages (young, mature, and old based on leaf position on axis); the lowest was observed in DOB-2. The number of PG and oil content were positively correlated; however, an inverse relationship was observed between leaf age and the number of PG. The extract from green herbage was compared for their chemical compositions through chemical profiling. The highest anethole were observed in DOB-1 at full blooming stage. Overall, the sweet basil accessions DOB-1 and DOB-5 were superior in herbage, oil, and anethole yield that can be used further in improvement programs.


Since the deformation instruments of Hegang Seismic Station put into use in 2006,deformation observation has become an important mean in precursor monitoring,which has provided a reliable observation data for seismic precursory data accumulation and scientific research.But the some factors are interfered in observation,such as lightning,humid surroundings,cave rainfall of natural factors,and some related human factors.According to the actual condition of Hegang seismic station,the problems frequently happened in observation have been discussed. In order to improve the quality and efficiency of observation the solutions were also proposed.


Knowledge is an important asset that can result in innovation and competitive advantage for companies. This paper provides a literature review based on perspectives proposed in a paper written by Karl M. Wiig almost two decades ago which forecasted development of Knowledge Management. The aim of this paper is to compare Wiigâ??s predictions with the current state of Knowledge Management literature to see how true his forecasts turned out to be. Moreover, the current literature is reviewed in order to find out which subtopics of Knowledge Management should be key topics for future research.


Efficient short-term production control depends on the ability to forecast future behavior of a job shop when it is loaded according to a particular schedule. A simulation of the job shop process based on a well-suited job shop model can be used to evaluate that schedule according to such goals as low in-process inventory, high utilization of workers and facilities, and low tardiness so that some optimization by modifying the schedule can be performed. A dedicated class of augmented Petri nets is introduced as a notation for microscopic deterministic job shop models which are well suited for short-term production control, including job shop scheduling. It is shown how these Petri nets can be automatically transformed into CPM nets using occurrence structures. These CPM nets represent the job shop schedule. In contrast to Gantt charts they are not restricted to the information about the temporal ordering of events of the shop floor, but also contain the full causal structure of the job shop process as well as assertions about the critical path. An attempt is made to determine whether there is a fundamental limit of deterministic simulation of manufacturing facilities emerging out of chaos phenomena due to incomplete specification of deterministic models.<<ETX>>


This paper discussed the possibility of obtaining electrochemical impedance spec-troscopy (EIS) responses of zinc rich paints (ZRP) using serial double-cell (SDC).The influence of counter electrode was outlined. An equivalent circuit (EC) for thedouble-cell was then discussed. The relationship between EC, the time constant, theparameters in EC of SDC and those of two single cells was also discussed. The resultsgained by serial double cell test are consistent with those of single cell test. It can beconcluded that double cell test method can be used to study ZRP completely.


This is an attempt to describe and explain some of the forms of bladder dysfunction which are encountered in a long-term orthopedic hospital. Some patients present with acute retention but many appear with 'incontinence' which is often overflow. Initially many are catheterized and it is helpful in subsequent management to know if the bladder distension was painful or painless and what was the volume of the residual urine.


INTRODUCTION The Waardenburg syndromes (WS) form a family of disorders, characterised by pigmentation abnormalities and sensorineural hearing loss, with diverse genetic causes (Read and Newton, 1997; Spritz, 2006). The severity of deafness in WS individuals can range from mild to severe. Mutations in SOX10, EDN3 and EDNRB lead to WS type IV [WS4, also known as Waardenburg-Shah syndrome, or Yemenite deaf-blind syndrome (YDBS)], in which patients also present with Hirschsprung's disease (also known as congenital megacolon) (Puffenberger et al. In humans, different heterozygous effects have been associated with different SOX10 alleles, with some resulting in WS4 (Pingault et al., 1998; Pingault et al., 2002) and others causing a more complex and severe neurocristopathy known as PCWH syndrome. This syndrome causes peripheral demyelinating neuropathy, central dysmyelinating leukodystrophy, WS and Hirschsprung's disease The distinction between the different alleles depends upon whether nonsense-mediated decay of the mRNA prevents the translation of truncated, dominant negative SOX10 proteins: PCWH results from dominant negative mutations, whereas WS4 results from haploinsufficiency (Inoue et al., 2004). Deletions at


ABSTRACT This article examines how the author of the First Epistle of John uses family metaphorics rhetorically to convince his adherents of their identity as Christians, and to persuade them towards certain conduct in relation to their identity. He employs a network of metaphors to describe the character of this community life, which was familiar to the people of the first century Mediterranean world. These metaphors have been used in conjunction with various rhetorical devices. This article commences with a discussion of what family metaphorics is, followed by a discussion of the use of familial images in rhetoric. The gist of the article concerns an application of "family dynamics" in the discourse of "metaphor" and "rhetoric".


In the research work, a discourse analysis of the worldview of users of the Kazakhstani segment of social networks and the opinions of experts was carried out in order to determine the processes of religiousization in Kazakhstan and the ideological orientations of the population. The results of a sociological study and the report of the US Commission on International Religious Freedom (USCIRF) were also considered. The author of the article draws his own conclusions by analyzing the content of social networks and online platforms.


and what proportion were medically qualified-or is it largely scientists without a medical degree who are affected? Despite the report's shortcomings, however, its proposals should be taken seriously. The C80m used for short-term contracts, the association calculates, could fund instead some 5000 permanent research staff and 2400 postgraduate students. It recommends better integration of funding agencies to co-ordinate policies and a career structure similar to that of hospital medicine, with a professional body to promote the interests and maintain the standards of research workers. Neither this proposal nor the Ciba suggestion of more shortterm grants is likely to be widely accepted in the near future; but might not both be tried, on a limited scale in different centres, with detailed evaluations ? Meanwhile other aspects of careers and remuneration need attention. Financially as well as in terms of risk, a doctor choosing an academic career may be penalised in several ways; and the quantity and quality of applicants inevitably suffer.7 The Ciba meeting agreed that research fellowships should carry much higher stipends and that there should be parity of salaries and conditions of service between the universities and NHS, including distinction awards that take account of academic excellence and compensation for forgoing sessions of private practice and, in the case of younger doctors, extra duty allowances. The system that forces Nobel prizewinners to earn less than clinical research workers also needs scrutiny. But if money is to be found for all this clearly more economic types of organisation will have to be developed. Another change needed is in attitudes to research. A doctor who is fired to do a spell of research should be encouraged, and not penalised if he returns to the clinical ladder; training schedules should be devised less rigidly and with more sympathy for clinical science.8 Too few research workers of high calibre and too few leaders of research; thought the Ciba meeting, are emerging in Britain and this is not a problem only of money. Training students, at school and university, how to think and how to discover the excitement of medical science-in the face perhaps of popular disillusion with science-need not cost money; but it calls for a radical look at both examination syllabuses and teaching.


Cryptomyces maximus is a conspicuous ascomycete, which is easy to identify due to its characteristic ecology and morphological appearance. The fungus was found in three locations in the northwesternmost part of the country, 99 years after the first find in Southern Finland in 1913. Four recent records made in Northern Norway are also published. The host range of the fungus is expanded with three willow species.


It already exists within the US Food and Drug Administration, argues a former clinical reviewer of psychotropic drugs at the FDA


We would like to thank Dr. Colgan for his interest in our paper. We hadn't previously considered the relationship between ice cliff height (defined by Dr. Colgan as the maximum height of a glacier's calving face above sea level) and calving rate in the model, so it was interesting to look back over the results and address this question. Dr. Colgan refers to both ice cliff height and relative crevasse depth as interesting parameters to examine. If we define relative crevasse depth as the ratio of crevasse depth to ice cliff height we find that at the terminus there is only small variation in this ratio, which remains close to 1 throughout most model runs. If we instead take an average over a slightly wider horizontal extent, the precise value depends strongly on the shape of the crevasse field, which is very variable and affected by relatively small changes in ice


The high power duplexer array illustrated in Figure 1 consists of two balanced hybrid duplexers. Each duplexer is rated at 5 megawatts. The high power transmission is divided equally into two paths. Each path furnishes power to half an orthogonal-feed RADAR antenna which radiates 10 megawatts in a circular pattern. During high power transmission, the diode driver simultaneously supply forward bias to all T-R diodes. Since the conducting diodes offer a short-circuit across the collinear ports of the high power hybrids, the hybrids are able to route most of the power into the antenna. The leakage signals which escape the T-R short-circuits are terminated harmlessly in the dummy loads which are located on the low power hybrids. Total high power isolation is the sum of the T-R and hybrid isolations. Total high power transmission loss is the sum of the hybrid line and T-R short-circuit losses for each parallel path.


Circadian rhythms modulate cell division and metabolism in cancer and may potentiate a tumor-suppressive role in lung tumorigenesis [1]. Circadian rhythms are oscillations of multiple biologic processes directed by endogenous clocks and may be functionally disrupted in various cancers such as breast, ovarian, endometrial, prostate and hematologic malignancies [2]. Silencing expression of the Clock gene in glioma cells down regulates c-Myc and Cyclin B1 and up regulates p53 and may play a significant role in inhibiting apoptosis by attenuating pro-apoptotic signaling [3]. O6-Methylguanine transferase constitutes a mechanism of transfer of alkyl groups to the acceptor cysteine in a manner that exemplifies the epigenesis of a series of protective mechanisms toward the repair of DNA-adduct lesions in carcinogenesis. The mechanistic removal of methyl groups interacts with the methylation of the promoter of O6-methylguanine transferase that renders the transferase inactive. The spectrum of activation of ethyl guanine is included within oscillatory cycles of activation and de-activation that affirms epigenesis of profile mechanisms even in the absence of self-progressing lesions in the cellular DNA.


ANNOTATION Over the centuries, the territory of what is now Uzbekistan has been one of the well-developed scientific, educational and spiritual centers of the world. Its history and thousands of manuscripts in the funds of the country confirm that it has produced many scholars on the one hand, and on the other hand, these scholars have paid special attention to science. A large part of manuscripts in the funds of the country is devoted to Islamic sciences such as Tafsir, Hadith, Fiqh, Kalam, Balagha, Logic and Arabic linguistics. One of these manuscripts is Abu Khafs Nasafi's (467-537/1074-1142) work "Al-Taysir fi `Ilm al-Tafsir". The manuscript is devoted to the Science of Tafsir and contains of five volumes. Seven manuscript copies of this work are stored in the Fund of the Institute of Oriental Studies named after Abu Rayhan Biruni under the Academy of Sciences of the Republic of Uzbekistan. A scientific analysis of these sources confirms that these copies were not fully saved. Manuscript copies of the work "al-Taysir fi `Ilm al-Taysir" are stored not only in our country, but in other countries too. Particularly, there are 77 copies of this work in the libraries of Turkey. These manuscripts are well preserved than other copies of this work. The article gives information about manuscript copies of the work "al-Taysir fi `Ilm alTaysir" in the Sulaymaniyah library of Turkey. Калит сўзлар: Абу Ҳафс Умар Насафий, тафсир, Ат-тайсир фи илмит-тафсир, оят, имон, ҳадис, замонасининг олими, усул, услуб. Ключевые слова: Абу Хафс Умар Насафи, тафсир, ат-тайсир фи илмит-тафсир, аят, вера, хадис, ученый периода времени, метод, стиль.


PROXIMITY CIRCUIT OSCILLATING GENERATING cyclically A Pseudo-SWING NOT MAINTAINED. A PROCESSING CIRCUIT PRESENTS COMPARATOR 14 TO COMPARE THE TENSION V RELAXATION OF SWING CIRCUIT TO A PREDETERMINED THRESHOLD AND CIRCUIT LOGIC 13 THAT gENERATED THE ONE HAND, PULSE S2 CONTROL LOW REPORT CYCLE FOR A SWITCH 11 SERIES WITH SWING CIRCUIT AND THE OTHER ONE OUTPUT SIGNAL S3 FUNCTION PULSE MEASUREMENT S1 ISSUED BY THE DIAL. CLOSING TIME SWITCH 11 IS CONSIDERABLY LESS THAN HALF PERIOD Pseudo-SWING.


This study discloses that syndrome has two layers which comprise manifest layer(ML) named symptoms and latent layer(LL) named pathogenesis. It is a key and core to diferentiate pathogenesis which discloses essential association and is simple expression of it. The LL indicates obvious rules which are linear or nonlinear expressions of pathogenic elements or pathogenic unit. PEs disclose key elements(for example, position of disease and quality of disease), and PUs that bear characteristic of hierarchy are sub-units of syndrome diferentiation which have clear indicators. They have obvious cluster of disease. As creates structure of syndrome, an importance will be attached to pathogenesis and the mind of syndrome diferentiation will be strengthened. Thus syndrome diferentiation becomes lexible and well-regulated so that it will be simple and operable.


In this article, we investigate the application of wavelet packet transform as a novel spectrum sensing approach. The main attraction for wavelet packets is the tradeoffs they offer in terms of satisfying various performance metrics such as frequency resolution, variance of the estimated power spectral density (PSD) and complexity. The results of the experiments show that the wavelet based approach offers great flexibility, reconfigure ability and adaptability apart from its performances which are comparable and at times even better than Fourier based estimates.


PURPOSE: To examine eCB responses to acute and chronic aerobic exercise in SUD patients. METHODS: Twenty-one SUD patients (35 ± 9 yrs) were recruited from local intensive outpatient treatment programs. Participants were randomized to either treatment-as-usual (TAU, at their outpatient clinic) or TAU plus aerobic exercise training (EX). EX participants engaged in supervised, moderate-intensity exercise sessions 3 x/wk for 6 wks. TAU participants came into the laboratory once per week for assessments and a quiet rest session. At 0(baseline), 3(mid), and 6(post) wks, participants provided blood samples before and after exercise or quiet rest to assess plasma eCB concentrations (anandamide [AEA] and 2-arachidonoylglycerol [2-AG]). Data were analyzed using mixed model ANOVAs and Cohen's d effect size calculations. RESULTS: There was a significant group X time interaction for AEA (p < 0.001). Simple effects indicated that AEA increased acutely after exercise in the EX group (p < 0.001) but did not change after quiet rest in the TAU group (p = 0.39). There were no group differences or significant changes in 2-AG (p > 0.05). Effect size calculations indicated there were small to moderate increases in AEA (d = 0.36) and 2-AG (d = 0.37) concentrations from 0 to 6 weeks in the EX group but small to moderate decreases in AEA (d = -0.42) and 2-AG (d = -0.40) concentrations in the TAU group, though these changes were not statistically significant. CONCLUSION: These results indicate that aerobic exercise is able to activate the eCB system in SUD patients, which may contribute to improved treatment outcomes. Exercise may also increase basal eCB concentrations over time, suggesting that exercise could be one method to restore eCB function in SUD patients. Additional investigations with larger sample sizes and longer exercise program durations are warranted. Supported by NIH R36DA040140 and the UW Virginia Horne Henry Fund.


Introduction: Uterine malignancies, the vast majority of which are endometrial cancers, constitute the most common type of gynecological neoplasms in developed countries. The  primary treatment for endometrial cancer is hysterectomy and bilateral salpingoophorectomy. Women with endometrial cancer can be subjected to either total abdominal hysterectomy (TAH) or to an increasingly recommended total laparoscopic hysterectomy (TLH). We decided to verify whether published evidence supports TLH as an effective, less invasive than TAH albeit still equally radical treatment for endometrial malignancies. Material and methods: The systematic review included articles indexed in MEDLINE (PubMed) and EBSCO, published between January 1974 and January 2017. The  search was based on the  following keywords and combinations thereof: "laparoscopy", "laparotomy", "endometrial cancer", "comparative". Twenty-six full-text articles were included in the meta-analysis. Results: A total of 5,996 patients were eligible for the analysis, among them 2,833 (47.2%) women subjected to TLH and 3,163 (52.8%) who underwent TAH. Total laparoscopic hysterectomy is associated with shorter hospital stay, faster recovery, lesser blood loss and fewer intraand postoperative blood transfusions, reduced pain, and a lower reoperation rate than conventional TAH. Conclusions: All analyzed studies demonstrated that TLH is a safe and effective treatment option in endometrial cancer patients. This procedure is markedly less invasive than TAH. However, considering several contraindications for laparoscopy, such as peritoneal invasion, cardiorespiratory failure, history of  previous surgery and large size of  the  uterus, qualification for a given procedure needs to be preceded by a detailed evaluation.


In recent years, the advent of social media platforms has led users to freely express their opinions on various subjects, including politics, society, health, education, finance, and even business-related issues. However, this widespread usage of social media has also increased the risk of its misuse by some groups resulting in spreading hate speeches or offensive language. This paper investigates machine learning methods for hate speech classification and compared its results with advanced deep learning models to evaluate its efficiency. The data from Twitter, a popular microblogging social media platform for sharing short digital content, was used for experiments in this study. Each tweet was labeled into one of three categories: hate speech, offensive, neutral. Four machine learning methods were investigated: logistic regression (LR), random forest (RF), naive Bayes (NB), and support vector machine (SVM). The results were compared with two deep learning-based models: recurrent neural networks (RNN) and bidirectional encoder representations (BERT). The overall results indicated that both machine learning and deep learning models were effective for hate speech recognition. The highest overall accuracy was obtained using BERT (87.78%), while SVM produced the best (84.66%) among traditional classifiers.


ABSTRACT:In this article, I reread Edgar Allan Poe's "The Journal of Julius Rodman" in an archipelagic mode (Roberts and Stephens). The novel reimagines and remaps American space as a "fluid" and island-studded landscape (Dimock) of shifting identities, blurring timelines, and uncertain boundaries. An archipelagic rereading of "Rodman" extends backwards in time the critical purchase of Roberts and Stephens's ideas to the moment when the continental identity of the United States solidified. But the significance of this rereading goes beyond bringing new materials into—and consequently expanding the interpretive range of—the terraqueous perspective of archipelagic American studies. "Rodman" forms part of a hemispheric archive that must be read archipelagically and continentally. Poe's novel applies this continental-insular doubling dissolutionally and dis-illusionally to the nineteenth-century expansionism of the United States. "Rodman" calls attention to the land- and seascapes (the Glissantian paysages) of the Americas. Poe narrates American history in "Rodman" as a fluid and terraqueous landscape of coursing rivers that interconnect continents and seas. I conclude the piece by reflecting on the symbolic importance of rivers within the archipelagic Americas.


Objective:To study clinical effects of a new-bone-grafting method combined with memorably-compressive swan-like connector in the treatment of non-union of upper limb diaphysis.Methods:Ninty-three(107 pieces) patients with bony non-union of humerus,ulna,radius and clavicle were reviewed in the present study.Self-iliac graft or allograft were implanted under the special enviroment provided by swan-like memorably-compressive connector(SMC).Several bone-grafting methods such as splinting,seeding and boring,combined with packing and padding were performed.If necessory,the grafting bone was also put between the fracture ends so as to accelerate bone-healing and avoid bone shortness and defect.This new method was applied to 50 pieces of humerus,28 ulna and radius,14 ulna,11 radius,4 clavicle.The patients exercised early and took X-ray examination periodicly after operation.Results:All the patients were followed up for an average of 2.25 years.The period of bone re-union ranged from 2.5 to 6.0 months,with an average of 3.8 months.The patients with non-union fractures were healed with lamellar bone without any complications such as osteomyelitis and joint stiffiness,and the joint function was satisfactory.Conclusion:This graft implantation combined with SMC is efficient,sufficient and stable,indicating that it will be a new effective method to treat non-union of upper limb disphysis.


As the role of genetic science in everyday life has grown, policymakers have become concerned about Americans' understandings of this science. Much effort has been devoted to formal schooling, but less attention has been paid to the role of public culture in shaping public understanding of genetics. Research into public cultural messages about genetics has claimed that the public is likely to adopt problematic accounts, but few studies have explored the public's articulation of these messages. This study is based on 25 focus groups convened to explore the lay public's understanding of genetics. The study found that the public processed a greater variety of messages than assumed by previous researchers, including documentaries, non-sciencefiction films, and popular television in addition to previous researchers' focus on science fiction and news media. The study also found that the public does not process the messages through the linear, transmission model assumed by previous research. The public processes messages about genetics complexly and critically. On the basis of these findings, the study suggests that researchers should include a greater variety of texts about genetics in their research and attend more fully to audience processing in addition to content analyses of these texts.


sponding chairpersons checked "yes." However, when later tabulation showed that 141 of the 315 chairpersons who responded had commented upon their answer, it was thought that an analysis of the comments might permit a fuller understanding of what some English department chairpersons meant when they said they "desire the services of a reading specialist in the senior high school." With the preceding in mind, the comments appended to the 133 positive and eight negative responses to the "reading specialist question" were read and divided into five categories:


Abstract There are many geographic and historical examples of Muslim women leaders, yet questions about women's ability to lead and the kinds of leadership women can assume are still a part of scholarly and public debates among Muslims. In this article, based on two years of ethnographic fieldwork in the Ferghana Valley (Uzbekistan), I provide examples of Muslim women's leadership and argue that in order to fully understand women's leadership we need to question the assumption that men and women desire the same forms of leadership. A desire for leadership is not intrinsic to women (or humans in general) but is socio-historically specific. Approaching critically some existing assumptions about women's leadership, I identify and provide examples of different, equally important, forms of leadership that a specific socio-historical context has engendered. Keywords: Women's leadership, Islam, Uzbekistan People's Professor Feruza-opa (2) was described by some of her students as "the one who brings Islamic knowledge and spiritual peace into the hearts of the believers." Her other students called her a "people's professor." She called herself an otincha, a religious teacher. As she said, she "taught Islam" to some local women and occasionally children; some local men came by periodically to get her advice. At a meeting in 2002 in the Ferghana Valley, I asked Feruza-opa about Hizb-ut-Tahrir (the Party of Liberation), a transnational Islamist movement with the aim of establishing an Islamic State, which has became a prominent actor in regional political discourse in the first decade of the twenty first century. She replied, "they [the Hizb] think they have authority to go against the existing authority. I think that they will not do anything, just aggravate. Muhammad said 'do not go against the authority: good or bad, it is all from Allah. Do not go against the Time [history]: it is still God's creation.' All their parties ... it is a waste of time. Many of them, men and women are in prison." Feruza-opa did not support a vision such as Hizbut-Tahrir's of the Valley (or Uzbekistan) as an Islamic state. Her emphasis, in her words, was on "Muslim" and "Islamic" living, which according to Feruza-opa, heavily depended on one's religious education and ritual prayer: "When you pray--keep the line with what Allah wants. 'Five times a day remember Me' [referring to Allah] ... Namoz (ritual prayer) keeps you from [doing] different bad things. If you read namoz Allah will give you [grant your wishes]." Feruza-opa saw corporal and intellectual learning about "Islamic living" as the only viable way of changing individuals, the local community and Uzbek society at large; as the only way of "not wasting time" and not being imprisoned. Feruza-opa believed in and stressed the transformative value of education: Our people are ovam hulq [uneducated people]. One needs to change people slowly. Otinchalar should also do it slowly, not fast. I believe that people should read the Qur'an more. Those who read will change themselves ... We are yet to learn our religion. My mahallah [neighborhood], my students--they do not do and do not allow others to do gnoh [bad/evil deeds] because they know Islam. Mullahs [male religious leaders] also should not read for themselves; they should read for and with the people.... One needs to share what God gives you. If it is illim [knowledge, Ar. 'ilm] you should share it too. What we can and must do is to tell people about Islam, to share knowledge, to educate each other and ovam hulq slowly. For Feruza-opa and women like her, individual and societal transformation through religious education was a slow moral process beginning with the sharing of (religious) knowledge. Through this sharing at religious ceremonies or during religious lessons, women like Feruza-opa, (3) who were educated at the Soviet secular schools and had different levels of religious education acquired through family members, homeschools and/or self-education, actively engaged in religious renewal in the Valley. …


The invention relates to hand cream prepared from effective components in banana peels. The hand cream is prepared from the following components in percentage by mass: 5-7 percent of glyceryl stearate, 8-10 percent of stearic acid, 11-12 percent of vaseline, 8-10 percent of liquid paraffin, 10-12 percent of glycerinum, 0.5-1.0 percent of lauryl sodium sulfate, 6-8 percent of banana peel pectin, 0.5-1.0 percent of banana peel polysaccharide, 0.5-1.0 percent of banana polyphenol, and 38.0-50.5 percent of deionized water. The invention also provides a method for preparing the hand cream. The hand cream has an excellent moistening effect, contains a plurality of moistening components with deep nourishing and moistening effects, so that hand skin can be smooth and oily, and rich in color.Furthermore, the hand cream has excellent oxidation resistance and chapping resistance.


Extreme multi-label classification (XMC) aims to assign to an instance the most relevant subset of labels from a colossal label set. Due to modern applications that lead to massive label sets, the scalability of XMC has attracted much recent attention from both academia and industry. In this paper, we establish a three-stage framework to solve XMC efficiently, which includes 1) indexing the labels, 2) matching the instance to the relevant indices, and 3) ranking the labels from the relevant indices. This framework unifies many existing XMC approaches. Based on this framework, we propose a modular deep learning approach SLINMER: Semantic Label Indexing, Neural Matching, and Efficient Ranking. The label indexing stage of SLINMER can adopt different semantic label representations leading to different configurations of SLINMER. Empirically, we demonstrate that several individual configurations of SLINMER achieve superior performance than the state-of-the-art XMC approaches on several benchmark datasets. Moreover, by ensembling those configurations, SLINMER can achieve even better results. In particular, on a Wiki dataset with around 0.5 millions of labels, the precision@1 is increased from 61% to 67%.


Reaction of 10H-pyrido[3,2-b][1,4]benzothiazines 1 possessing a 10-methyl 1f, 10-(3-dimethylaminopropyl) 1b, or 10-(2-dimethylaminopropyl) 1c substituent, with n-butyllithium and methyl chloroformate or diethyl chlorophosphate affords predominantly 1,2-dihydropyridines 11 and the 4-substituted derivatives 12. The 1,7-disubstituted product 15b was obtained from reaction of the 10-methyl compound 1f with p-fluorobenzoyl chloride. On the other hand, treatment of the 10-methyl analog 1f with trifluoromethanesulfonyl chloride gave the unexpected 4-chloro derivative 12c and 13c which probably arises from the 1-trifluoromethanesulfonyl-1,2-dihydropyridine 11c via elimination of trifluoromethanesulfonic (sulfinic) acid. The N-10 dealkylated product 1a was obtained from reaction of the 10-(1-methyl-2-dimethylaminoethyl) analog 1g with n-butyllithium and methyl chloroformate, whereas a similar reaction employing the 10-(2-dimethylaminoethyl) derivative 1h gave rise to the N-methoxycarbonyl derivative 18. On the oth...


PURPOSE: A video encoding apparatus and method thereof based on a data functional method are provided to maximize the parallelism and availability of a decoding process after separating bit stream regardless of data dependency. CONSTITUTION: A variable length decoding unit(410) performs variable length encoding/parsing and separates an encoding parameter based on a function partition method. MB(Macro Block) process information of a cluster and an encoding parameter is obtained by separating encoding function.


OBJECTIVE
The purpose of this article is to illustrate multitechnique imaging findings in patients with primary and secondary vasculitides involving large and medium-sized vessels and their mimics.

CONCLUSION
Large and medium-sized vessels are affected by many primary and secondary inflammatory disorders or mimicking conditions, often presenting similar imaging characteristics. Knowledge of distinctive imaging features such as location, length, and degree of vessel wall enhancement as well as the particular clinical settings will help the clinician in appropriately narrowing down the differential diagnosis.


The concept of diversity management refers to the approach that recognizes the individual differences of the employees in the organization and values the differences and enables them to be used for the purpose of the organization. The study is based on the view that the better each individual manages the differences of the community members with whom he or she interacts, the knowledge sharing in these communities will increase. The sample of the research carried out with the relational screening model within the scope of the general screening model is composed of administrators and teachers working in public primary and secondary schools in Unye District of Ordu Province. The reason why the study sample consists of teachers is that teachers, due to their profession, constantly acquire knowledge and share this knowledge with all their students, colleagues and their parents when necessary, regardless of the difference. The data set of the study was obtained in line with demographic information, employees' perceptions of differences management, and levels of knowledge sharing. The data were evaluated by descriptive analysis and Pearson correlation analysis through SPSS. As a result of these findings, it was concluded that there is a moderate and positive relationship between differences management perceptions and knowledge sharing behavior.


Spectral properties of simply treated soil samples were analyzed in this research by using Nicolet intelligent Fourier transform(FT) infrared spectrum.The quantitative analysis models were found to the soil available phosphorus(P),available kalium(K) content and pH values.The result shows that, the correlation coefficients for P,K and pH is 0.661,0.721 and 0.834,standard error of prediction(SEP) is 4.180 mg·kg-1,19.653 mg·kg-1 and 0.095,and root mean standard error of prediction(RMSEP) is 3.93 mg·kg-1,21.9 mg·kg-1 and 0.114,respectively.


Topics: Epidemiology, pathogenesis, diagnosis, treatment, and prevention of the diabetic foot Contact: Dr. N.C. Schaper, Dept. of Internal Medicine, Academic Hospital Maastricht, P.O. Box 5800, 6202 AZ Maastricht, The Netherlands. Tel: 31 (0) 43-876-543; Fax: 31 (0) 43-875-006. 8th Annual General Meeting of the European Diabetic Nephropathy Study Group (An Official Study Group of the European Association for the Study of Diabetes) 19-20 May 1995 Heidelberg, Germany Contact: Ruggero Mangili, MD, Divisione Medicina I, Istituto Scientiflco San Raffaele, Via Olgettina 60, 1-20132 Milan, Italy. Tel: 39-2-2643-2325; Fax: 39-2-2643-5090. 3rd Annual International Conference on Diabetes and Indigenous Peoples 27-30 May 1995 Winnipeg, Manitoba, Canada Deadline: 30 December 1994 for abstracts. Contact: Canadian Conference Planning Committee, Program & Scientific Subcommittee, 405-800 Portage Ave., Winnipeg, R3G 0N4 Manitoba, Canada. Tel: 204-9456831; Fax: 204-948-2190. 5th Congress of the International Pancreas and Islet Transplant Association 18-22 June 1995 Miami Beach, FL Location: Eden Roc Resort Hotel Deadline: 16 January 1995 for abstracts; 5 May 1995 for reduced registration fee; 15 May 1995 for guaranteed hotel reservation. Sponsorship: the Diabetes Research Institute Foundation and the Juvenile Diabetes Foundation International. Topics: Pancreas and islet transplantation and other new approaches for the treatment


Abstract This article focuses on the motion planning and control of an automated differential-driven two-wheeled E-puck robot using Generalized Regression Neural Network (GRNN) architecture in the Virtual Robot Experimentation Platform (V-REP) software platform among scattered obstacles. The main advantage of this GRNN over the feedforward neural network is that it provides accurate results in a short period with minimal error. First, the designed GRNN architecture receives real-time obstacle information from the Infra-Red (IR) sensors of an E-puck robot. According to IR sensor data interpretation, this architecture sends the left and right wheel velocities command to the E-puck robot in the V-REP software platform. In the present study, the GRNN architecture includes the MIMO system, i.e., multiple inputs (IR sensors data) and multiple outputs (left and right wheel velocities). The three-dimensional (3D) motion and orientation results of the GRNN architecture-controlled E-puck robot are carried out in the V-REP software platform among scattered and wall-type obstacles. Further on, compared with the feedforward neural network, the proposed GRNN architecture obtains better navigation path length with minimum error results.


This master thesis examines a change in health care, in a county council in Norrbotten's county. This change, which is referred to as "competence-exchange" (kompetensvaxling) by the studied organiz ...


This research is performed in order to test the influence of the variable
Capital Adequacy Ratio (CAR), Non Performing Loan (NPL), Biaya Operasi
Pendapatan (BOPO), Net Interest Margin (NIM), and Loan to Deposit Ratio
(LDR), toward Earning Changes.
Sampling technique used is purposive sampling with criteria as General
Banking in Indonesia who provide financial report and traded during period 2004
through 2007 and forwarded to Bank Indonesia. The Data is based on publicity
Indonesia Banking Directory since 2004 to 2007. Obtained by amount sampel as
much 102 company from 136 banking company in Indonesia 2004-2007 period.
Analysis technique used is doubled regression with smallest square equation and
hypothesis test use t-statistic to test coefficient of regression partial and also fstatistic
to test the truth of collectively influence in level of significance 5%.
Others also done a classic assumption test covering normality test,
multicolinierity test, heteroscedastisity test and autocorrelation test.
During research period show as data research was normally
distributed. Based on multicolinierity test, heteroscedasticity test and
autocorrelation test variable digressing of classic assumption has not founded, its
indicate that the available data has fulfill the condition to use multi linier
regression model. From the result of analyse indicate that data CAR, NIM, NPL,
and BOPO in partial significant toward earning changes big bank, while only
BOPO and NIM have an significant effect to Earning Changes small bank.

Penelitian ini dilakukan untuk menguji pengaruh variabel Capital
Adequacy Ratio (CAR), Non Performing Loan (NPL), Biaya Operasi Pendapatan
(BOPO), Net Interest Margin (NIM), dan Loan to Deposit Ratio (LDR), terhadap
Perubahan Laba (∆ Laba).
Teknik sampling yang digunakan adalah purposive sampling dengan
kriteria bank umum di Indonesia yang menyajikan laporan keuangan periode 2004
sampai dengan 2007 dan bank umum yang memperoleh laba periode 2004-2007.
Data diperoleh berdasarkan publikasi Direktori Perbankan Indonesia periode
tahun 2004 sampai dengan tahun 2007. Diperoleh jumlah sampel sebanyak 102
perusahaan dari 136 bank umum di Indonesia periode 2004-2007. Teknik analisis
yang digunakan adalah regresi berganda dengan persamaan kuadrat terkecil dan
uji hipotesis menggunakan t-statistik untuk menguji koefisien regresi parsial serta
f-statistik untuk menguji keberartian pengaruh secara bersama-sama dengan level
of significance 5%. Selain itu juga dilakukan uji asumsi klasik yang meliputi uji
normalitas, uji multikolinieritas, uji heteroskedastisitas dan uji autokorelasi.
Selama periode pengamatan menunjukkan bahwa data penelitian
berdistribusi normal. Berdasarkan uji multikolinieritas, uji heteroskedastisitas dan
uji autokorelasi tidak ditemukan variabel yang menyimpang dari asumsi klasik,
hal ini menunjukkan bahwa data yang tersedia telah memenuhi syarat untuk
menggunakan model persamaan regresi linier berganda. Dari hasil analisis
menunjukkan bahwa data CAR, NIM, NPL, dan BOPO secara parsial signifikan
terhadap perubahan Laba pada bank besar, sedangkan LDR tidak berpengaruh
signifikan terhadap perubahan laba pada bank besar Untuk kategori bank kecil
hanya BOPO dan NIM yang signifikan berpengaruh terhadap perubahan Laba,
sedangkan CAR, NPL, dan LDR tidak berpengaruh signifikan terhadap perubahan
laba pada bank kecil.


Introduction: QT dispersion (QTd) and Tp-e interval show controversial results in incidence of sustained ventricular arrhythmias (SVA) in patients with heart failure (HF). In patients with implanted cardiac resynchronization therapy (CRT) device, there is a unique opportunity to record SVAs. The aim of this study was to evaluate the effects of QTd and Tp-e interval on the incidence of SVAs after simultaneous biventricular (Biv) pacing. Methods: In the present study, 31 consecutive patients with advanced HF and implanted CRT device were evaluated one year for possible SVAs, corrected QT (QTc), QTd, and Tp-e interval. Patients were divided into two groups; with (group 1) and without (group 2) SVAs. Results: Among the studied patients, 5 (16%) experienced SVAs. The intrinsic and Biv pacing QTd were 70.74 ± 18.00 and 89.26 ± 28.00 msec, and 95.09 ± 44 and 88.09 ± 33 msec in group 1 and group 2, respectively (P = 0.18 and P = 0.16, respectively). Tp-e was not different between the two groups. In group 1, QTc increased from 438.83 ± 64 msec to 488.24 ± 48 msec (P = 0.13), and in group 2, it decreased from 499.70 ± 65.00 msec to 480.00 ± 31.00 msec after simultaneous Biv pacing (P = 0.13). Conclusion: QTd, Tp-e, and QTc did not differ significantly after Biv pacing to show any positive effect on the incidence of SVAs in part due to the severity of changes which already occur in patients with advanced HF. QTc, QTd, and Tp-e showed little changes after Biv pacing and probably do not have a significant role in the incidence of SVAs.


The present Research Project will be carried out in a company dedicated to thestorage and commercialization of finished products for construction. Theproducts that are sold reach both retailers and wholesalers in the geographical sector.The company under study has a significant problem that is the excessive storage of materials without rotation, something that undoubtedly harms the company and also makes the cash flow is not adequate to meet the tastes and demands of customers, that generates a bad image of the company. An inventory management system appropriate for the size of the company will be designed, for which a diagnosis will first be made of the way in which it is currently carried out, the management of the supply chain, the acquisitions and the core part they are the communications between the departments and personnel involved in the whole process of acquisition of the merchandise, as well as in the payments and in the warehousing. For the development of the research, current methodologies will be used, related to the supply chain, inventory models, procurement processes and communications. These last processes will be directly supported by the good practices of the PMI methodology, since they allow to generate clear guidelines for the organization within the company. The research concludes with an analysis of the benefits obtained from the implementation.


A number of serious health problems among children are caused by diarrhea, such as dehydration, hypovolemic shock, hypokalemia, seizures, malnutrition and even death. Padang was in on the fourth highest of diarrheal incident in 2020 which reached the percentage of 10.44%. This study aimed to determine the factors related to diarrheal incident in work area public health center of Andalas in Padang.  The research used cross sectional design that was started from January to June 2022. The research population was 125 mothers who came to Mother and Child Healthcare polyclinic of Andalas Public Health Center, with the total sample of 55 people using accidental sampling technique. This study used Analysis with Chi square test which was 95% CI. The results showed that there was a relationship between exclusive breastfeeding and knowledge of p-value (0.004), CTPS p- (0.004), and exclusive breastfeeding p-value (0.007). Suggested to public health center workers to conduct continuous cooperation through the health promotion in order to prevent this issue.


The Authors have studied the role of some general metabolites in the biosynthesis of the 22,23-dihydrostigmasterol in Wistaria Sinensis flowers, gathered during the period April—July. The rate of uptake of the following possible precursors has been investigated: [2-14C] acetate, [2-14C] pyruvate, [2,3-14C] succinate, [1,4-14C] succinate, [1,4-14C] fumarate, [5-14C] ketoglutarate, [1,5-14C] citrate and [2-14C] mevalonate. Metabolism periods of 12, 24, 36, 48 and 72 hours have been used. Mevalonate and acetate have shown the highest degree of incorporation, as in agreement with the known data on their role in the biosynthesis of sterols. The incorporation of radioactivity from [2,3-14C] succinate has been significant from the other compounds negligible. Some metabolic relationships have been found especially among acetate, pyruvate, succinate and the other substances involved in the Krebs cycle.


The recent publication1 concerning oxygen rearrngement process in the mass spectra of aromatic and unsturated esters parallels an investigation by the auther on similar compounds. Some further definitive aspects of this study are reported here.


This interview was published in the catalogue for Peter Alwast's solo exhibition, "Future Perfect", at the Institute of Modern Art, Brisbane, in August 2011.


Living digitalized times is a challenge not only for the individuals but also for businesses. As people tend to think that robots will slowly replace their activity, it's important to consider this mindset and implement measures to alleviate this mentality. In these times, being a laggard on new trends is very likely to affect business performance, taking into account also specific market competition. Organizations worldwide are gradually adapting their strategies based on different types of business models, adapted to their specific objectives and field of activity. The business model denotes a concept of organization and functioning which is aimed to assure the proper functioning of the organization, taking into account the numerous specific influence factors: environment, competition, technology, mission and vision. The aim of this study is to identify the impact of technology and digitalization on business models and to analyse the strengths and weaknesses of the traditional manner of business model implementation in an organization as compared to the digital-focused approach. Moreover, observing the European trends on digital transformation of business, new approaches introduced by technology and strategies on digitalization would represent a point of interest for future studies on this subject. For this purpose, taking into consideration other authors opinion on this, an outline of the existing literature on this subject will be performed.


The Coalinga earthquake of magnitude (M) 6.7 partly destroyed the town of Coalinga in Central California and prompted extensive geologic, seismologic, and geophysical investigations as to its setting, source, and cause. This book presents the results of twenty-three investigations on different aspects of the earthquake and its effects. The earthquake was associated with reverse faulting on several faults along the boundary between the Coast Ranges and the Great Valley. Similar geologic settings occur elsewhere along this boundary.


The quality characteristics of mine drainage with high turbidity were described on the basis of investigating the particle size distribution,the characteristics of suspended particle surface,and the coagulating characteristics in mine drainage,and the influencing factors on the affinity between coagulants and suspended particles in mine drainage treatment were analyzed.The results show that the suspended particles in mine drainage mainly consist of coal and rock grains with small size and negative electric charge which make them hard to naturally subside.As the coal rank goes to higher,the wettability of coal grains and the affinity between coal and coagulants decreases gradually.


This paper presents 130 GHz on-chip dielectric resonator antenna (DRA) arrays using a standard CMOS technology. The half-mode cavity feeding structure is used to excite the dominant and higher-order modes (TEx<inf>δ11</inf> and TEx<inf>δ13</inf>) of the dielectric resonators (DRs) in the antenna design. The 2 × 1 and 4 × 1 arrays have been both investigated with the proposed antenna element. The 2 × 1 arrays with TEx<inf>δ11</inf> mode and TEx<inf>δ13</inf> mode DRs achieve the measured peak gain of 6.3 dBi and 7 dBi at 134 GHz, respectively. The 4 × 1 arrays have also been demonstrated to be 7 dBi gain with TExδ11 mode DR and 8.2 dBi gain with TExδ13 mode DR. Moreover, the arrays have the 3-dB gain bandwidth of ∼ 10%. In the silicon-based on-chip antenna array design, the suitable number of array elements is 2 to 4. More array elements would not increase the gain obviously while occupying lager chip area.


Heparin‐induced thrombocytopenia/thrombosis (HIT) is a severe thrombotic disorder that occurs in ≈1% of patients treated with heparin. Affected patients commonly develop antibodies that recognize PF4/heparin complexes that may form on the surface of activated platelets and on the endothelium. However, it has not been established that anti‐PF4/heparin antibodies are responsible for the clinical manifestations of HIT. To address this issue, we employed a recently developed model of active immunity to study the effect of IgG anti‐PF4/heparin antibody in vivo. In previous studies we have shown that it is possible to induce autoimmune diseases such as systemic lupus erythematosus (SLE), anti‐phospholipid syndrome (APS) or vasculitis in naive mice by active immunization with anti‐DNA, anti‐cardiolipin and anti‐neutrophil cytoplasmic antibodies, respectively. Immunized animals develop anti‐idiotypic antibodies (Ab2) and, after 2–4 months, anti‐anti‐idiotypic antibodies (Ab3). Ab3s generated in this manner often simulate the binding activity of Ab1 and their expression correlates with the development of specific clinical manifestations typical of the respective human disease. Based on this experience, naive BALB/c mice were immunized with IgG anti‐PF4/heparin antibodies isolated from two patients with HIT. The actively immunized mice developed mouse anti‐PF4/heparin antibody (Ab3). Administration of unfractionated heparin, but not low molecular weight heparin (LMWH), to the actively immunized animals induced thrombocytopenia by day 4 of drug exposure. There was no evidence of thrombosis. The results of this study support the importance of anti‐PF4/heparin antibodies in the pathogenesis of HIT. Further, this model may help to elucidate the factors responsible for thrombosis as well as providing means to assess new treatment options for patients with this disorder.


The present network information safety situations are introduced.Based upon discussion of the connotative meanings of network information safety major menaces it confronts by network information safety are analyzed,at the same time corresponding countermeasures as well as realization techniques are proposed in order to ensure information safety of computer network to make full use of computer network.


A method for protein staining after isoelectric focusing (IEF) in polyacrylamide gel is described in which the total time for fixation, staining and complete gel background destaining is reduced to 3–5 min. This is achieved by (i) staining dry gels on silanized supports instead of hydrated gels, (ii) reducing gel thickness to 50 μm, (iii) using Servalyt carrier ampholytes with good destaining properties, and (iv) using dyes with low affinity for carrier ampholytes, namely Serva Violet 17 or 49, facilitating destaining of gel background. The sensitivity of staining is 100–200 ng protein/ mm2 over a 10 cm separation distance and 20–30 ng protein/ mm2 over 3 cm gels (miniature focusing). Addition of 5–20 % methyl acetate to the staining or destaining solution reduces the sensitivity of staining significantly. Most effective fixation of proteins in 50 μm gels is achieved with 20% trichloroacetic acid. In solutions of alcohol and acetic acid, appreciable amounts of proteins are leached after incubation for 5–20 min. Paraformaldehyde, malondialdehyde or glutaraldehyde (5–10 %) exhibit no fixative effect on proteins in 50 μm gels when used directly or after precipitation of the proteins with trichloroacetic acid. The selective leaching of proteins under a variety of experimental conditions shows that adequate fixation is particularly important in work with basic, low molecular weight and/or hydrophobic proteins.


Objective To construct the adenoviral expressing system of hepatitis B virus reverse polymerase gene(RT/RnaseH domain) and identify the transcription of this system in Huh7 cells.Methods HBV/P(RT/RNAaseH) gene fragment was amplified from pUC19-1.24HBV and subsequently inserted into pCMV-Tag2 vector.pCMV-Tag2-RT/RNAaseH vector was recombined after transformed into Bj5183 bacterium.The recombinant plasmids extracted from Bj5183 bacterium was transfected into Ad293 cells and encapsidated into adenovirus particles.The adenovirus in the supernatant of Ad293 cells was collected and used to infect Huh7 cells.After 48h,the transcription of HBV/P gene(RT/RnaseH domain) was detected by reverse-transcript PCR.Results HBV/P(RT/RNAaseH) gene fragment was successfully amplified and pCMV-Tag2-RT/RNAaseH vector was successfully constructed.The recombinant plasmid was transfected into AD293 cells.The supernatant containing adenovirus could infect Huh7 cells and the transcription of HBV/P gene can be detected in the cells.Conclusion The adenoviral expressing system of hepatitis B virus reverse polymerase gene(RT/RnaseH domain) was successfully constructed and they can transcribe the targeted gene in Huh7 cells but the expression of RT/RNAaseH protein needs further determination.


The invention relates to a memory array arranged in banks and sectors and associated decoders. The memory array (150) includes a plurality of memory banks (B), each having a plurality of sectors (S) and a plurality of sector decoders, each sector decoder operatively associated with a sector (S). A first plurality of lines provides first signals, and a second plurality of lines provides second signals. A first decoder apparatus is operatively associated with the first plurality of lines for receiving the first signals and for providing a first address signal by means of a first single line to a sector decoder of a memory bank (B). A second decoder apparatus is operatively associated with the second plurality of lines for receiving the second signals and for providing a second address signal by means of a second single line to a sector decoder of a memory bank (B).


Iran's and Pakistan's foreign policies towards each other are established in a security structure, and both sides have adopted securitized foreign policies towards each other. The most crucial factor contributing to the balanced relations between these two countries, despite their securitized foreign policy, is their neighborhood and geopolitical necessity. This article discusses numerous influential factors affecting the securitization of Iran-Pakistan foreign policies, including the Arab Spring, the Syrian and Yemeni crisis, Chabahar port, relations with China and India, as well as terrorism and radicalism. It is argued that both sides try to avoid conflicts and high tensions with each other due to neighborhood and geopolitical necessities.


The research studies focus on physical characterization of oleic acid polyol
based polyurethane (PUR) coatings. Basically, polyurethanes are derived from the
reactions between polyols and isocyanates. The most common polyols used in PUR
production are made from petroleum derivatives. In this research, a new technology has
been developed which results in producing PUR coatings based on polyols synthesized
from oleic acid.
Three different polyols, with various oleic acid contents were used in the
preparation of polyurethane (PUR) coatings. The polyols were designated as Alk28,
Alk40 and Alk65, in which 28, 40 and 65 represents the oleic acid percentage of the
polyols formulation. These polyols were reacted with aromatic isocyanate (toluene 2, 4-
diisocyanate, TDI) to form PUR coatings. Properties such as acid number and hydroxyl
value of the polyols have been determined. The polyols were characterized by Infrared
(IR) spectroscopic. By varying the oleic acid content in the polyols, the amount of
flexible side chains incorporated in the polymer was varied. On the other hand, the
NCO/OH ratios of the PURs samples were varied to see the cross-linking effects as the
ratios increased.
The characterization of PURs coating were carried out by IR spectroscopy, DSC
analysis, TGA analysis and XRD analysis. Physico-chemical properties such as drying
time, pencil hardness, adhesion properties, solvent resistance and corrosion/chemical
resistant determination were reported. The PUR made from the lowest oleic acid
content exhibited the best overall physical properties followed by the medium and the
highest oleic acid content. The properties were enhanced as the NCO/OH ratio
increased.
A part of the research was concentrated on electrical properties of the materials.
Two types of conductivity measurement were performed which involved alternative
current, ac and direct current, dc. The purpose of performing the ac and dc
conductivity measurements for the PURs was to investigate the alternating current
response as a function of the frequency to the applied field in order to study the
dielectric behaviour of the material. The nature of conduction mechanism involved in
the PUR was also determined. Mechanical and creep properties of the samples were
also determined in the studies. The analysis revealed that the PURs made with polyols
of the lowest oleic acid content have the best mechanical and creep properties due to
introduction of higher degree of cross-linking.


Serverless computing platforms are becoming increasingly popular for data analytics applications due to their low management overhead and granular billing strategies. Such analytics frameworks use a Directed Acyclic Graph (DAG) structure, in which serverless functions, which are fine-grained tasks, are represented as nodes and data-dependencies between the functions are represented as edges. Passing intermediate (ephemeral) data from one function to another has been receiving attention of late, with works proposing various storage systems and methods of optimization for them. The state-of-practice method is to pass the ephemeral data through remote storage, either disk-based (e.g., Amazon S3), which is slow, or memory-based (e.g., ElastiCache Redis), which is expensive. Despite the potential of some prominent NoSQL databases, like Apache Cassandra and ScyllaDB, which utilize both memory and disk, prevailing opinions suggest they are ill-suited for ephemeral data, being tailored more for long-term storage. In our study, titled Asgard, we rigorously examine this assumption. Using Amazon Web Services (AWS) as a testbed with two popular serverless applications, we explore scenarios like fanout and varying workloads, gauging the performance benefits of configuring NoSQL databases in a DAG-aware way. Surprisingly, we found that, per end-to-end latency normalized by $ cost, Apache Cassandra's default setup surpassed Redis by up to 326% and S3 by up to 189%. When optimized with Asgard, Cassandra outdid its own default configuration by up to 47%. This underscores specific instances where NoSQL databases can outshine the current state-of-practice.


The communication of new and significant information in medicine is becoming an enormous task. In some fields the storage and retrieval of information can only be successful when performed by electronic devices. Good clinical medicine, however, is practiced by sympathetic, knowledgeable, and critical physicians aided by machines. The mind of the doctor, or for that matter the scientist, must still do the greatest part of the data collecting, processing and read-out. Unfortunately, as new significant scientific information increases, an apparently even greater expansion of the trite and trivial or even untrue threatens to obscure the important knowledge needed to make wise and meaningful judgments. Serious medical journals have the major responsibility of providing physicians with valid information as effectively as possible. The editors must select the most significant contributions from those which are submitted and especially must insure that the material which is published meets the highest standards of knowledge


The last decade has proved especially rich in works devoted to the cultural history of Napoleon's empire, including several studies lavished on individual artists, on propaganda and on the press. Architecture and the development of urban space, in contrast, have suffered from relative neglect, despite the significance of the imprint left by the Napoleonic regime. This imprint is especially apparent in Paris, the subject of R.'s book. Napoleon intended Paris to be the 'new Rome', a city that would not only surpass the classical original, but also more recent attempts to recreate Rome in Paris including especially the efforts of Louis XIV. Indeed, Louis XIV figures almost as prominently as Napoleon in R.'s study, on the grounds that he set the standard that his Corsican successor strove to surpass. Napoleon did not create the lure of the classical world, as this was already well developed when he came to power. This book therefore looks not so much at the two-way relationship between Napoleon and the classical Roman past, but rather a three-way relationship that also includes pre-Napoleonic (and especially seventeenth-century) reinventions of classical Rome. It does so, using a variety of sources, including the monuments and cityscape of Paris itself, and contemporary guidebooks, newspapers and other literature. Within these parameters, R. focuses on areas that one would expect to see in such a study, including especially the Napoleonic reinvention of classical Rome's triumphal architecture. Unsurprisingly, Napoleon, like Louis XIV, found the custom of the Roman triumph politically appealing. The intended stage for the Napoleonic reinvention of this ancient form was a planned triumphal axis, running from thewest to east, across Paris. R. analyses this processional route in some detail in the second chapter. Its western anchor was provided by the Arc de Triomphe, perhaps the most famous Napoleonic monument in Paris. As such, R. gives it particular attention. This structure illustrates well how the architects of Napoleon, like those of Louis XIV previously, reinvented classical Roman monuments to fit modern circumstances. They were inspired in this case by the Arch of Titus in Rome, but they took no interest in the fact that this classical monument was located in the centre of Rome, and not positioned as a boundarymarker to the city aswas the casewith the larger Napoleonic copy. In this context and in others, R. provides the reader with a good sense of the limited state of knowledge about classical Roman architecture available to the planners and architects of the Napoleonic era. The Arc de Triomphe opened on to the Champs-Élysées, which in turn culminated in the Louvre-Tuileries complex. Adjacent to this space was the Place Vendôme, with the Vendôme Column in the centre. This monument was inspired by Trajan's Column, though the reader will be unsurprised to learn that the Napoleonic copy was slightly taller than the original, demonstrating Napoleon's superiority to even the best of Roman emperors. Beyond this, R. argues that the Vendôme Column also represented one-upmanship over Louis XIV, whose equestrian statue had previously occupied the site, and the French Republic, whose agents had wrecked the statue thereby clearing the way for the Napoleonic column. The impression made by the column on a pedestrian or rider moving along the adjacent processional route is provided by one of the more important illustrations included in the book. Heading further east along the axis, the reader ends up at the site previously occupied by the Bastille, and for which Napoleon's architects planned a bizarre fountain in the form of an elephant, a structure immortalised in Victor Hugo's Les Misérables. THE CLASSICAL REVIEW 282


Background: Cellulitis is an acute bacterial infection involving dermis and subcutaneous tissue characterized by erythema, induration and tenderness of the involved skin. Bacteremia is the presence of viable bacteria in the blood stream. Recent data suggests that incidence of bacteremia in cellulitis patients are increasing, most often in those with severe infections and comorbidities. Because of high morbidity and mortality associated with bacteremia it is critical to detect the incidence of bacteremia in cellulitis patients Materials & Methods: 50 clinically diagnosed cases of cellulitis who satisfied inclusion and exclusion criteria were taken for study. Sample was collected within 48 hrs of diagnosing the condition and was analyzed. Results: The incidence of bacteremia was 6%. Most frequently isolated bacteria was Beta Hemolytic Streptococcus. Two patients with positive blood culture were found to be diabetic. No antibiotic resistance detected in positive samples. Conclusion: Blood culture though not specific should be performed in patients who have factors increasing the risk of bacteremia. As the bacteremia can be associated with increased mortality it is better to do blood culture in all possible patients.


Three different antagonistic bacterial isolates, Pseudomonas fluoresces (Pf2), Bacillus subtilis (Bs3) and Rahnella acquatilis (Ra39) restricted the growth of Pectobacterium atrosepticum , the causal agent of black leg disease of potato, in vitro .   Under greenhouse and field conditions, potato plants pre-treated with the three antagonistic bacterial isolates, individually or in combination, showed reduced disease severity relative to non-treated control plants. All isolates produced siderophores in different degrees but did not produce indole acetic acid (IAA) or hydrogen cyanide (HCN).The obtained results indicated that combination of Pseudomonas fluoresces (Pf2), Bacillus subtilis (Bs3) and Rahnella acquatilis (Ra39) is beneficial in controlling black leg disease of potato caused by pectobacterium atrosepticum .


In 1976, the provincial parliament in Québec ratified the Charter of the French Language, or La Loi 101. The Charter is a collection of linguistic laws meant to promote the French language in Québec. Since its ratification, supporters of the Charter have called it a protection of "French‐Canadian identity". The Charter has also come under scrutiny from Anglophones (English speakers) and Allophones (non‐native English or French speakers) in Québec. This paper analyzes one group of Allophones, Chinese‐Canadians, in Québec's largest city, Montréal. In particular, this analysis examines how the Chinese‐Canadian community in Montréal perceives their self‐identity as threatened by La Loi 101 and believes this law is a form of forced assimilation.


Quintessentially, to be African-American is really to be a conglomeration of selves and experiences, at once changeable and circumscribed by laws and regulations which attempt to control rather than speak to the difference that constructs, empowers and sustains communities. The efficacy and creation of literary canons can be described in very much the same way; establishing what is "real" and "American" runs parallel with attempts to master borders (both perceived and unperceived), to discipline people whose imaginations consistently resist and/or subvert attempts to establish recognizable hegemony, and to impose normalcy through notions of reality defined, for lack of a better word, as tradition. We only have to look at the "family values" platform campaign of the 1992 presidential election for proof of the manic workings of "American"4 hegemony. In an introduction to the rise of realism in the American novel, noted Americanist Eric J. Sundquist observes that " [t]o escape the 'paralysis of tradition' is, of course, the typifying American gesture-in religion, in politics, in business, in literature, in life." If we follow Sundquist's offering, what makes us


My dissertation is a study of North Korean art as a site where politics, history, and culture meet. Art in North Korea fulfills a clear purpose. This is most apparent in the depiction of historical themes in North Korean art. History serves the political legitimization of the North Korean state and its leaders. My dissertation analyzes how art addresses historical themes in support of the revolution and its leaders based on North Korean art theoretical writings, reviews and critiques of paintings, art yearbooks, and history textbooks. My analysis reveals how North Korean art dramatizes and thereby creates an idealized reality that the viewers can emotionally relate to.


The chemical effects accompanying the predominantly electron capture decay of I to Te in aqueous solution were found to somewhat resemble the chemical effects of the isomeric decay of Te and of Te. Differences dependent on the different initial oxidation states were observed, but they were not as large as in the tellurium case. An easily oxidizable intermediate was also observed.


Objective To investigate the effects of E2F-1 gene silencing on multidrug resistance of human gastric cancer SGC7901/DDP cells and its possible mechanisms.Methods Gastric cancer SGC7901/DDP cells were seeded in 6 well plates and divided into three groups:the experimental group,blank control and the negative con-


The main purpose of this study was to identify strategies for adapting agricultural cooperatives to learning organization. Agricultural cooperatives are business organizations that fully examine all the economic, democratic and social dimensions of poverty reduction in rural areas simultaneously. This research is an exploratory research that was conducted in two parts: qualitative and quantitative. In the qualitative section, by holding several meetings with experts and through the method of brainstorming, the opportunities, threats, strengths and weaknesses for the adapting of the agricultural cooperative organization to learning organization were identified. Then, using the SWOT model, strategies and action plan were identified for adapting the cooperative organization to the learning organization. Also, in the quantitative part of the research that was conducted among the members of the cooperatives, through Structural Equation Modeling (SEM), the role of the identified strategies was evaluated and the designed model was approved. Based on the results, the predictive positive effect of identified strategies include: SO1 (β= 0.73, t-Value= 4.23, P< 0.001), SO2 (β= 0.79, t-Value=4.71, P< 0.001), SO3 (β= 0.81, t-Value=5.08, P< 0.001) and SO4 (β= 0.82, t-Value= 4.97, P< 0.001) on Adapting Cooperatives to the Learning Organization (ACLO). The findings showed that (R= 0.69) the identified strategies determined 69% of the variance in the ACLO.


Solid tumors display significant histological, genetic and micro-environmental intra-tumor heterogeneity that can change substantially over the course of their evolutionary trajectory. In particular, changes in the micro-environmental complexity within breast cancer such as hypoxic and nutrient deplete environments are associated with aggressive disease and a poor patient outcome. We sought to identify novel driver alterations in aggressive disease by employing a functional genomics screen in a 3-dimensional model of breast cancer progression that more accurately recapitulates in vivo micro-environmental heterogeneity. Screening of the top 200 recurrently mutated genes in breast cancer in cancer cell line spheroids identified several genes whose silencing impacted growth. A second targeted validation screen in a larger panel of triple negative cell line models showed that silencing of the histone acetyltransferase CREBBP, promoted growth in 3D but had limited effect under traditional 2D culture conditions. Investigation of TCGA and METABRIC datasets showed that CREBBP was more frequently mutated in triple negative breast cancers (TNBCs) and at least a third of TNBCs also displayed gene haploinsufficiency or complete loss of CREBBP. Interrogation of expression and proteomic datasets showed that loss of CREBBP resulted in the upregulation of the pro-proliferative transcription factor FOXM1. Significantly, this conserved FOXM1-driven transcriptional programme was also seen in multiple solid tumors with CREBBP alterations including lung, oesophageal, bladder and endometrial cancers. This was recapitulated in several CREBBP deficient cells where we identified that FOXM1 is driving altered metabolism, allowing cancer cells to grow under nutrient stress conditions. In summary, CREBBP is a bona fide tumor suppressor in up to a third of TNBCs, as well as a wide range of other solid tumors. CREBBP-altered tumors display up-regulation of FOXM1, which alters cancer cell metabolism under nutrient stress conditions. Moreover, CREBBP-altered tumors are selectively sensitive to small molecule inhibitors that target FOXM1 activity, suggesting that this maybe a viable targeted therapeutic approach for CREBBP altered cancers. Citation Format: Barrie Peck, Philip J. Bland, Patty T. Wai, Hannah Cottom, Sarah L. Maguire, Eamonn Morrison, Holly E. Barker, Divya Kriplani, Rebecca Marlow, Kalnisha Naidoo, Gareth Muirhead, Syed Haider, Frances Daley, Frederik Wallberg, Andrew N. Tutt, Rachael C. Natrajan. Modeling tumor microenvironmental heterogeneity identifies CREBBP as a novel tumor suppressor in breast cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 788.


Next-generation sequencing technologies provide a revolutionary tool for generating gene expression data. Starting with a fixed RNA sample, they construct a library of millions of differentially abundant short sequence tags or "reads", which constitute a fundamentally discrete measure of the level of gene expression. A common limitation in experiments using these technologies is the low number or even absence of biological replicates, which complicates the statistical analysis of digital gene expression data. Analysis of this type of data has often been based on modified tests originally devised for analysing microarrays; both these and even de novo methods for the analysis of RNA-seq data are plagued by the common problem of low replication. We propose a novel, non-parametric Bayesian approach for the analysis of digital gene expression data. We begin with a hierarchical model for modelling over-dispersed count data and a blocked Gibbs sampling algorithm for inferring the posterior distribution of model parameters conditional on these counts. The algorithm compensates for the problem of low numbers of biological replicates by clustering together genes with tag counts that are likely sampled from a common distribution and using this augmented sample for estimating the parameters of this distribution. The number of clusters is not decided a priori, but it is inferred along with the remaining model parameters. We demonstrate the ability of this approach to model biological data with high fidelity by applying the algorithm on a public dataset obtained from cancerous and non-cancerous neural tissues. Source code implementing the methodology presented in this paper takes the form of the Python Package DGEclust, which is freely available at the following link: https://bitbucket.org/DimitrisVavoulis/dgeclust.


This paper describes two different approaches to Mission Planning for earth observation missions: the approach followed in European Space Agency's ATOS-4 mission planning system prototype', and the approach followed for the operational Flight Operations Segment Mission Planning System of the Envisat earth observation mission. Both systems are introduced in their respective context, together with the underlying goals and constraints that have driven their development. Finally the re-usability of the ATOS-4 approach in the scope of an operational mission is discussed.


Bearing capacity of short precast pile in lagoon-marsh deposits area of Shanghai is researched based on in-situ data. In lagoon-marsh deposits area, there imbeds a thick layer of hard sandy silt and medium dense silty sand, which is so-called as shallow leck. Ultimate frictional resistance of the shallow leck for single pile can be obtained from the field loading test. The relationship between the ultimate frictional resistance and cone penetration resistance of the shallow leck is analyzed by comparing the test result and computing value of bearing capacity of single pile.


This function signal generator using DDS technology, AD9851 as the core, LCD12864 as LCD display module and matrix keyboard as input. The signal generator can produce sine and square wave, sine wave output frequency is 100Hz~10MHz and square wave is 100Hz~1MHz, frequency resolution is 0.04 Hz, and any adjustment to achieve two-step adjustment in the frequency range control modes and can display the frequency and stepper units generated waveform information. The signal generator has a frequency stability, fast frequency and amplitude stability, low waveform distortion, a simple circuit structure, small size, low power consumption, low price and so on.