In the preface to the first edition of the Critique of Pure Reason, published in 1781, Kant wrote: I know of no investigations that would be more important for getting to the bottom of the faculty that we call understanding and at the same time for determining the rules and limits of its employment than those that I have undertaken in the second part of the Transcendental Analytic, under the title of the Deduction of the Pure Concepts of the Understanding; they have also cost me the most, but not, I hope, unrewarded effort." (A XVI) However, the initial response to Kant's argument, which he also titled the "transcendental deduction of the categories" (A 85 /B 117), was largely one of incomprehension, and in the preface to the Metaphysical Foundations of Natural Science, published in 1786, Kant himself acknowledged that precisely "that part of the Critique which should have been the clearest was the most obscure, or even revolved in a circle" (4:474 n.). So in the second edition of the Critique , published the following year, Kant completely rewrote the transcendental deduction. He claimed that this revision touched only the manner of " presentation ," not the "propositions themselves and their grounds of proof" (B xxxvii-xxxviii). But in spite of Kant's efforts at clarification, the intervening two centuries have brought little agreement in the interpretation of the deduction, even on the fundamental question of whether the two editions of the Critique , in 1781 and 1787, try to answer the same question by means of the same argument. The last three decades alone have brought forth dozens of competing interpretations or "reconstructions" of Kant's transcendental deduction.


Manipulation do happens in our everyday life. Therefore, it is important to know the characteristic of manipulative behaviors to avoid someone from being manipulated by others. In doing so, the writer takes the data from Smallville because she finds many manipulation acts that are done by the characters, especially by Lex, Lucas, and Lionel Luthor. In the story, Lex wants to use his half brother, Lucas, to play against their father, Lionel. However, Lucas realizes it and he has his own plan. On the other side, Lionel also tries to control his sons by manipulating them. In order to know about the process of manipulation, the writer uses Speech Acts Theory of Austin to know what tactics that are used by the Luthors and for what motives they conduct the act of manipulation. It means that the scope of the study is Discourse Analysis and it focusses on locutionary, illocutionary and perlocutionary acts. After analysing each of the utterance, the writer figures that in Smallville, the Luthors use more than one tactic in order to make them succeed in achieving their goals, which are to control other people?s thoughts, behaviors, feelings, and to make decision for others. In other words, Lex, Lucas, and Lionel Luthor are capable of doing anything to get what they want, even though their actions might hurt others.


Objective: To investigate the frequnency of gene polymorphism in rs2235048 of ATP-binding cassette subfamily B member l transporter(ABCB1) gene and to elucidate the correlation between this polymophism and the occurrence of clopidogrel resistance(CR).Methods: Clopidogrel response was assessed by posttreatment ADP 20μmol/L-induced platelet aggregation.Clopidogrel resistance was defined by RPA(RPA≥70%),and all the enrolled 800 coronary artery diseases(CAD) patients after percutaneous coronary intervention(PCI) were divided into CR group and Non-CR(NCR) group.Genotypes were determined by polymerase chain reaction(PCR) and the sequences of rs2235048 of ABCB1 gene were analyzed.Results: The genotype frequencies in rs2235048 of ABCB1 gene conformed well to the Hardy-Weinberg equilibrium for both CR group and NCR group.Between the two groups,the genotype and allele frequency was similar(P=0.527 and 0.740,respectively).Conclusions: Based on the genetic analysis in patients after PCI with clopidogrel therapy,there was no correlation between ABCB1 rs2235048 polymorphism and clopidogrel resistance.


The article discusses artistic protests and forms of opposition in the democratic society. Taking into account different theoretical approaches, the attempt is made to clarify the notions of artistic protests and (artistic) political critique in the field of Lithuanian art research. The attention is paid to the neoliberal political consensus and its opposition. The categories such as strike, protest and disobedience are related not to more or less abstract "critical discourse", but to concrete artistic practices. Little evidence exists of sharp protests in post-soviet Lithuania, which deliberately chose democratic path of development, in opposition to some other post-soviet states (i.e. there have been no obvious tendencies of authoritarianism in the Baltic States and this fact could have caused feckless state of political or social disobedience). In the contemporary art, the phenomenon of protest was non-existent until the second half of the first decade of the XXI century (one could notice only one consistent oppositionist and radical activist of contemporary art – the scandalous artist from Alytus Redas Diržys, who consciously distanced himself from the "art of capital"). The most memorable artistic actions of urban protest so far took place in 2005 next to foreclosed "Lietuva" movie theatre in Vilnius, where the protest laboratory was established and activists protested against (illegal) privatization of public space. In this article, the chosen examples of protests during the first decade of the XXI century reflect some creative artistic trajectories (such as Nomeda and Gediminas Urbonas – the couple quite famous and well established in art world). First, the artistic critique against neoliberal agendas is defined along with the description of activist group Bavo, later on, the cases of artistic protest next to "Lietuva" movie theatre and the fluxist Vilnius urban policy (and the opposition against it) are analyzed.


My introduction to Francis Edwards came with a warning—like a pack of cigarettes. But it was not the surgeon general who cautioned me but another American Jesuit, Dennis Linehan. I was a scholastic, visiting Farm Street for the first time in June of 1977, as I investigated British doctoral programmes in history. Before Father Linehan introduced me to Francis, he advised me to avoid certain subjects: the identity of the author of the Shakespearian plays, the Cecils, William and Robert, and, most important, the Gunpowder Plot! Anyone who believes that events from four centuries ago can no longer arouse emotions, never sat at dinner with Francis Edwards and Kempie Webb as the conversation inevitably turned to the plot! Each defended his position with passion and certainty.


The purpose of the case study is to assess the internal and external factors that would contribute in terms of internal and external success factors in Small and Medium food Enterprises. The internal and external factors model adopted in this study is based on a study approach by Tahir, M. H and Aman, O; (2011) and Talib, H.H. et al; (2013). The study findings concluded that the measurement of the success factors practiced by the enterprise, included both internal factors: namely leadership, corporate planning, process management, customer focus and quality assurance process while the external factors included government support system and market accessibility. The internal and external factors identified have contributed to 'n' the product quality and business performance. The findings indicate that the degree of increase or decrease in the organization's quality performance was determined by the internal factors and supported by the external factors. Evidently, a strong and consistent internal factor influences the determinant performance factors of the small medium food entrepreneur.


The introduction of ZigBee wireless network protocol into the most important gas monitoring network in coal mine production can not only expand the monitoring range of gas concentration but also make some improvements to the monitoring network based on the delay of gas concentration monitoring. The introduction of support vector machine can get a monitoring network with gas concentration prediction function. Introduction In today's coal production process, the safety of mine gas has been the focus of attention of all sectors of society. Excessive gas concentration is the primary issue that threatens coal mine safety. When the concentration of oxygen in the air reaches about 10% and the gas concentration of 5-16%, the mixture will explode. Therefore monitoring gas concentration in the mine has become an important link in the current coal mine production. The reliability and timeliness of the monitoring system are of great significance to work safety. Due to the special underground environment and complex situations, the traditional manual measurement and the extended performance of wired sensor networks have various unsafe and unstable factors. The new wireless sensor network with its efficient and reliable features has been gradually replacing the traditional monitoring technology [1] . In this paper we use the more novel wireless sensor networks based on ZigBee protocol. In the mine set up with a small-scale gas measurement monitoring system and the host computer to collect real-time statistical data acquisition and forecast gas concentration and get better experimental results. ZigBee Wireless Sensor Network Introduction ZigBee technology is a short-range, low-power, low-rate wireless communication technology. It is based on the IEEE802.15.4 specification, in the data link layer, network layer and application layer to develop a corresponding interface specification. ZigBee nodes include full-function devices and simplified function devices, and these two functional devices form a star, tree and mesh-based topology. This topology generally accommodates 255 child nodes in a network group and can reach a maximum of 65536 child nodes by address expansion [2] . ZigBee wireless sensor network technology is quite prominent: the transmission distance can be 10 meters to 80 meters; its power consumption is very low, the power supply is simple; available working frequency bands are generally divided into 868MHz, 902 ~ 928MHz and 2.4 ~ 2.4835GHz. A working band the transmission rate in the above three bands are not the same respectively at 20kb/s, 40kb/s and 250kb/s or so. Based on these characteristics of ZigBee, there are many advantages for the application of this technology in the monitoring of coal mine gas to the establishment of a wireless monitoring network. The utility model has the advantages of low cost and simple network expansion and is suitable for application in a large-scale monitoring environment. The utility model has the advantages of more reliable reliability, higher gas concentration and wired sensor safety than normal manhole strong anti-interference ability and high fault tolerance. In the rapid development of spread spectrum communication technology downhole wireless sensor networks have begun to gradually apply. From the time and attendance system downhole personnel positioning system are in the underground coal mine wall to solve the problem of wireless signal absorption under the premise of using the current spread-spectrum communication technology to achieve underground wireless network communications. Mine gas concentration monitoring network to ZigBee technology represented by the development of wireless network monitoring and maturing is an inevitable trend. Wireless Monitoring Network Construction Since mine gas is ejected from coal and rock fractures during coal mining it is common to use hose extraction to the total gas extraction pipework at the upper corner of the previously measured gas concentration accumulation. Therefore, the design and construction of wireless sensor networks should give full consideration to the origin of gas. In view of the various mechanisms and factors of gas generation, we choose the network structure to configure each network node because this network structure can well correspond to the ductility of the coal mine face and roadway can solve the sensor fault tolerance in the node configuration sex. A network node is configured at intervals on the seam wall of the roadway and the working face, and by wearing the corresponding sensor to the workers in the first-line mining face of the well, we can get a good dynamic extensibility, and can actively avoid the defects of the gas concentration in the working face, and get more accurate monitoring value. The corresponding algorithm can be programmed and implemented on the corresponding industrial computer and the weighted processing is performed on the active nodes of the working face to obtain better monitoring results. CC2510 built-in positioning system to accurately find the gas concentration exceeded or may exceed the specific location and combined with the latest "coal and gas co-mining technology" we can make a better way of handling. In the choice of sensor nodes taking into account the measurement range and positioning of the measuring point, based on the choice of sensor nodes taking into account the measuring range and measuring point positioning based on the choice of CHIPCON in SmartRF04 technology on the production of CC2510 wireless sensor chip. The hardware architecture of the wireless sensor network node device based on the chip is shown in Figure 1. It is a highly integrated industrial RF transceiver that enables the development of MAC and PHY layer communication protocol standards by ZigBee and operates in the 2.4 GHz band and builds a wide range of monitoring networks through communication protocols and node extensions. Figure 1. Wireless sensor network node device hardware structure. Taking into account the chip has a good data processing module and positioning system module, we can according to the specific situation to improve the traditional monitoring system mode. In view of the special situation that the gas concentration change is hard to grasp the support vector machine prediction model can be introduced into the wireless sensor network. Early warning in the case of gas concentrations may exceed the standard, thereby improving the safety factor to prevent gas accumulation and gas outburst accidents. Support Vector Machine Prediction Model SVM is a kind of statistical learning theory put forward formally by Vapnik in 1995. It takes the structural risk minimization empirical risk minimization and VC dimension as the background. In fact SVM is to find an optimal function so that each subset of a function set can be obtained within the appropriate minimum confidence interval the smallest empirical risk [3,4,5] . We conducted local experiments on the gas concentration data monitored by two sensor nodes set up at the coal mining face. Figure 2. Schematic diagram of sensor position. Figure 3. System flow chart. As shown in Figure 2, we select the coal mining face near the coal wall set up T1 and T2 two sensor network nodes. After ZigBee network communications sent to the host computer and get the appropriate two sets of data values. Then through the pre-processing of the data to get the corresponding weight training samples. Standardized processing of data first, the formula is ' i i i x x x σ − = (1) where, i x is the average value of each component of i x and σ is the standard deviation of each component of i x . The processed data samples according to the flow shown in Figure 3. training and then amended to get a good SVM forecasting model. In the choice of confidence interval we generally need to refer to a series of conditions such as uniform convergence and convergence speed of learning machine. Following the consistency of the learning process finding a balance between real risk and experiential risk avoids the risk of over-learning and under-learning conditions so that the confidence range can be truly adapted to a range of conditions of gas concentration monitoring [6,7] . We know that support vector machines are assumed to be a set of processed data sets, {( , )} i i i A x y } 1 , 1 { , − + ∈ ∈ y R x n (2) that can be separated by a hyperplane ( ) 0( , ) n w x b w R b R • + = ∈ ∈ . (3) where w is the weight vector andb is the offset of the optimal plane shift [8] . We need to normalize this hyperplane. That is (( ) ) 1, 1,..., i i y w x b i l • + ≥ = . (4) In this way we can represent the optimal classification surface as a problem that maximizes the classification distance based on the hyperplane. That is to find 2 1 2 ( ) w w Φ = (5) to minimize the problem. In this way 1 ( ) 1 ( , ( , )) n emp w i i n i R L y f x w


The results of bisulfite sequencing and methylation-specific PCR showed that the promoter of AcMNPV immediate-early gene(ie0p)is CpG methylated at a relatively high level,and its methylation level changed during infection reaching the lowest around 8hpost infection.To study the effect of DNA methylation on the regulation of ie0 and ie1 promoters,plasmids p402-ie1and p402-ie0M-A,which can express IE0and IE1protein,respectively,and reporter plasmids pie0p-luc and pie1p-luc were reconstructed.Methylated reporter plasmid DNA was obtained by treating the plasmid DNA with bacterial methyltransferase M.SssⅠin vitro.The results verified that IE0activated ie0p,whereas IE1inhibited it.DNA methylation was found to reduce the activity of ie0 and ie1 promoter greatly.By contrast,both IE0and IE1increased ie1p activity,and maintained such activation after methylation.By cotransfecting different ratio of p402-ie1and p402-ie0M-A with reporter plasmid into Sf9cells,we demonstrated that DNA methylation could reverse the regulation by IE0and IE1on ie0p when IE0IE1.These results suggest that DNA methylation can affect baculovirus gene expression and regulation.


In this paper, we present a new semantic challenge to the moral error theory. Its first component calls upon moral error theorists to deliver a deontic semantics that is consistent with the error-theoretic denial of moral truths by returning the truth-value false to all moral deontic sentences. We call this the 'consistency challenge' to the moral error theory. Its second component demands that error theorists explain in which way moral deontic assertions can be seen to differ in meaning despite necessarily sharing the same intension. We call this the 'triviality challenge' to the moral error theory. Error theorists can either meet the consistency challenge or the triviality challenge, we argue, but are hard pressed to meet both.


When publishing the data set that is involved in personal privacy,the publisher should guarantee individual sensitive information security,simultaneously,as much as possible to improve the data usefulness and it is the great challenge in the privacy protection faces. In the recent years,the domestic and foreign scholars have conducted the extensive research. Carrying on the summary to the research results at the right moment,it can be clear about the research direction. This paper surveyed privacy protection achievements in the PPDP field,introduced the typical privacy protection model and technology, privacy metrics and algorithms. Focused on PPDP in different application scenarios,and pointed out that the PPDP possible research topics and application prospects.


Through the use of an experimental method the influence of inlet water temperature on the shock wave pressure rise characteristics of steam water two phase flows has been investigated. During the tests steam was extracted from a cogeneration plant to serve as the power source. A shock wave pressure rise device of the two phase flow is composed of a steam nozzle, a mixing chamber and relevant valves and piping. An inlet water critical temperature has been discovered in the course of the tests. If the inlet water temperature is greater than the critical value, the pressure rise characteristics of the above cited pressure rise device will decrease dramatically.


The electron resonant tunneling in a T-stub low-dimensional conductor was studied in terms of the lattice Green's function method.The numerical calculations show that the electrons can pass through the conductor for some Fermi levels.With the increase of the Fermi energy,more and more transport model take apart in the tunneling,and then the transmission increase from 1 to 2,3 and so on.The numerical calculation results will be helpful for quantum device design.


This paper provides a discussion on how degradation develops and affects the performance of the gas turbine. Because the function of a gas turbine is the result of the fine-tuned cooperation of many different components, the emphasis of this paper is on the gas turbine and its components as a system. Therefore, the interaction of components is studied in detail. An engine model is subjected to various types of degradation, and the effect on operating parameters is studied. The focus is on three areas: How does component degradation impact the operating points of the engine compressor, how does component degradation impact full load and part load gas turbine performance characteristics, and how does component degradation impact measurable engine operating parameters. Experimental data are provided that supports the theoretical conclusion. Parameters that indicate levels of degradation are outlined, thus providing guidance for condition monitoring practice.


Eosinophil cationic protein and tidal flow volume loops in children 0-2 years of age. K.C. Lodrup Carlsen, R. Halvorsen, S. Ahlstedt, K-H. Carlsen. ERS Journals Ltd 1995. ABSTRACT: Many children with recurrent wheezing in early childhood develop asthma. Objective parameters to describe different groups of wheezers are limit- ed, but tidal flow volume (TFV) response to inhaled salbutamol has demonstrated differences between children with and without asthma. Also, eosinophil cationic protein (ECP) has been associated with declining lung function in older children. We therefore investigated whether lung function and serum ECP (s-ECP) could dif- ferentiate between groups of wheezy young children. TFV loops were measured in 79 awake children (mean age 14 months). Mini- mum two wheezy episodes (mean 3.2) or minimum 4 weeks persistent wheeze were reported in 41 children (cases), whereas the 38 controls had no history of wheeze. Airways responsiveness (change in ratio of time until peak expiratory flow to total expiratory time (t PEF/t E) after inhaled nebulized salbutamol) was measured in 26 cases and 24 controls. Serum ECP and serum myeloperoxidase (s-MPO) were mea- sured in all children. Cases had significantly lower mean t PEF/t E (0.21) than controls (0.33), and high- er mean s-ECP (21.9 µg·L-1) than controls (14.0 µg·L-1). Serum ECP (but not s-MPO) correlated significantly with the percentage change in tPEF/t E from baseline (r=0.7), but not with initial tPEF/tE. Serum ECP increased significantly with increas- ing immunoglobulin E (IgE), airways responsiveness and eosinophil count, but decreased with increasing age. TFV responsiveness to salbutamol and s-ECP levels correlate strongly, both prob- ably reflecting airways inflammation, and may possibly be valuable prognostic tools in recurrent wheezy infants and toddlers.


email@example.com A 51yr old man presented to the emergency department with lower abdomen pain and vomiting for the last 2 days. There was no preceding history of trauma, surgery. Physical examination revealed lower abdomen tenderness. Mild decreased bowel sound. Laboratory data, ECG, chest X-ray were normal. He had been discharged with a diagnosis of enteritis. However, due to persistent abdomen pain, he re-attended and abdomen CT was obtained. The abdomen CT showed thrombosis in Superior Mesenteric Artery (SMA), which is a common finding of SMA dissection due to dissecting hematoma within the true or false lumen (FIGURE 1A.). Inhomogeneous enhancement of IVC is also noted, which is common during arterial phase, and should not be misunderstood as thrombosis (FIGURE 1A).


The occurrence of sporophytes of Chorda tomentosa and C. filum in the southern Gulf of St. Lawrence was correlated with the field temperature regime. Temperature tolerances of gametophytes and young sporophytes of both species were tested in culture, using isolates from both the gulf and the outer Atlantic coast of Nova Scotia. Chorda tomentosa sporophytes appeared in late winter when the water surface was frozen, were fertile from April to June, and died when water temperature approached 20 °C. In culture, sporophytes tolerated −1 to 15 but became moribund at 20 °C. Gametophytes in constant temperature reproduced readily at 5 °C, occasionally at 0 and 10 °C, but not at higher temperatures; they survived to 24 °C. After 6 months in dim light at 10 °C some gametophytes also released gametes at 15 °C. Sporophytes of C. filum appeared in the field in spring after the water temperature had risen above 1 °C and persisted through the warm months. New sporophytes appeared in the autumn after the water temperatur...


Thyrotropin-releasing hormone (TRH), sodium valproate, AG-3-5 (1-[2-hydroxyphenyl]-4-[3ni t rophenyl]1 ,2 ,3 ,6te t rahydropyr imidine-2-one) , RX 336-M (7,8-dihydro-5',6'-dimethylcyclohex-5'eno-1',2',8',14 codeinone), and Sgd 8473 (c~-[(4chlorobenzylideneamino)-oxy]-isobutyric acid) each induced repetitive shaking of the body of rats after intraperitoneal injection. This action of the five diverse chemicals appears to be subserved by a common pharmacological component, because pretreatment with d-lysergic acid diethylamide (0 .03-1 .0 mg kg 1, s.c.) attenuated the shaking behavior in a dose-related manner, and cross tolerance was found between RX 336-M and TRH, sodium valproate, and AG-3-5.


Vangama picea , sp. nov. (Figs. 1~7) Length (incl. teg.): ♂ 12.5 mm~13
mm, ♀ 14.5mm~15 mm; Length of vertex: ♂ 5.0mm~5.5 mm, ♀6.0mm~6.5 mm. This
species resembles Vangama steneosaura Distant in appearance and colour, but the central
ridge of vertex and end of clavus without stramineous spots, pygofer round on distal margin
without ventral process, female Ⅶth sternite distinctly straight on posterior margin. Holotype
♂, paratypes 7 ♂♂, 9 ♀ ♀, Maolan, Guizhou, 27~29-Ⅴ-1998, coll. Wang Lianmin and Li
Zizhong.All the type specimens are deposited in Guizhou Agricultural College.


Sophora alopecuroides are important ecological grasses of the ecosystem in North China and the raw material for drug industry.The study were mainly about eliminating hard seed,the methods of improving seed vigor index,and the optimal soil moisture and sowing depth of seed germination.The results showed that the reason for the low rate of germination was that seed crust was too intensive.The measure of improving germinating rate was to scrap seeds with abrasive paper or to treat them with H2SO4(65%) for 20 minutes.In addition,the method of boosting seed vigor was to treat seeds with H2SO4(65%) for 20 minutes,then with GA3(0.02%).For the seeds of Sophora alopecuroides,the optimal soil moisture was 8%~12% and optimal sowing depth was 0~3 cm.


Freshwater spadefish(Colossoma brachypomum) with initial weight of(82.26±5.13) g in netcage were fed with diets supplemented with different levels of chitosan(0,0.2%,0.4%,0.6%,0.8%,1.0%) for 60d to examine the effects of dietary chitosan on growth and non-specific immunity of freshwater spadefish,and the appropriate dosage of chitosan for dietary supplementation.The results showed that the final weight,specific growth rate(SGR),feed efficiency ratio(FER) and protein efficiency ratio(PER) of group 0.6% was highest,significantly higher than groups 0,0.2%,0.4% and 1.0%(P0.05).Hepatosomatic indexes(HSI) of groups 0.6%,0.8% and 1.0% were significantly lower than groups 0,0.2% and 0.4%(P0.05).Viscerosomatic index(VSI) of groups 0.6%,0.8% and 1.0% were significantly lower than group 0(P0.05).Activity of lysozyme(LZM) of group 0.6% was highest,significantly higher than groups 0 and 0.2%(P0.05).Activity of super oxide dismutase(SOD) of group 0.6% was significantly higher than that of other groups(P0.05).Activity of acid phosphatase(ACP) of group 0.6% was higher than groups 0 and 0.2%(P0.05).Mortality of groups 0.6%,0.8% and 1.0% were significantly lower than group 0(P0.05) after being challenged with live Aeromonas hydrophila in 14 d.Thus adding chitosan in freshwater spadefish feed appropriately can improve their growth performance,feed utilization,non-specific immune function and the resistance to infection with Aeromonas hydrophila.The supplement of 0.6%~0.8% chitosan was optimum for the feed of freshwater spadefish.


In this study,Probiotic properties of B.breve GRX031 isolated from intestinal tracts of old people in Xinjiang,China,were assessed.The experments of the acid-and bile-tolerant,antimicrobial activity against pathogenic E.coli and Gastric Helicobacter pylori,the ability of adhere to human intestinal cells in vitro and anti-oxidation in vivo were carried out.The results showed that: B.breve GRX031 can stay in pH 2.0 and 0.3% bile salt more than five hours,and the diameter of anti-microbial circles against pathogenic E.coli and Gastric Helicobacter pylori were 12.6mm and 13.2mm(mean,n=6),respectively,the ability of adhere to Caco-2 was 9.2±2.21 bacteria/cell.The mice fed with B.breve GRX031 for 8 days,no significant difference was found in sera SOD concentration between experimental and control groups(P0.05),however,the mice in group that fed with B.breve GRX031 of 4×107 g-1·d-1,the content of MDA in sera was significantly lower than control groups(P0.01),which indicated B.breve GRX031 had the ability of anti-oxidation in vivo.


The miRNAs are a new class with about 20 -24 nts of small non-coding RNA presented extensively in the plant, nematodes and human cells. At present the study on miRNAs is hot in the field of current gene expression regulation. In this paper, the contents of A,U,G,C,GC and AU in the known miRNA sequences in thirteen vertebrate are analyzed. In order to determine the base contents of miRNA in vertebrate, miRNA database (version 9.0) provided by Sanger's laboratory is employed and the contents of A,U,G,C,GC and AU in the known miRNAs sequences found in thirteen kinds of vertebrate are determined by means of bioinformatics softwares. The results show that there are no obvious difference in almost all the above species'contents of A and G in miRNA, and the content of AU is higher than that of GC in any sequence studied. Furthennore, no siginificant difference are found in the contents of the four kinds of base composition between the pre-miRNA and mat-miRNA in the same species, however, C in Drosophila melanogaster is excluded.


The experimental study methods to analyze the shrinkage distortions of commonly accepted and used concretes at home and abroad are summarized, which is significant in dealing with the shrinkage cracks of concrete.


The Ge/TiO2 composite thin films are deposited on polyimide substrate by RF sputtering method. The aim of this work is to develop a flexible and affordable solar cells material using Ge/TiO2 composite thin films. The films are deposited by varying sputtering times from 30 to 60 minutes. The surface morphological and structural composition of the thin films are studied by FESEM and X-ray diffraction. FESEM image shows the distribution of elements and the cross section of Ge/TiO2 composite thin films. XRD patterns reveal the morphology structural changes from amorphous to crystalline phase with increasing sputtering time.


Solid-state detectors that operate in orbit are required to withstand harsh space environment conditions. Among the various phenomena able to damage the sensors, X-ray detectors are subjected to impacts of orbital debris and micrometeoroids whenever, to be sensitive to low energy photons, they need to be ``directly'' exposed to the sky. The LOFT mission, proposed for the M3 class opportunity of the ESA Cosmic Vision, has a very-large sensitive area (greater than 10 m2) made of Silicon Drift Detectors (SDD). Moreover, the satellite includes an X-ray Wide-Field Monitor based on the same SDD detectors. Here we present the results of a test campaign at the Cosmic Dust Accelerator Facility at MPIK in Heidelberg aimed at the space qualification of the detectors with respect to this phenomenon.


The task of identifying named entities from the discussion texts in Web forums faces the challenge of noisy names. As the names are often misspelled or abbreviated, the conventional techniques have failed to detect the noisy names properly. In this paper we propose a global context based framework for handling the noisy names. The framework is tested on a named entity recognition system designed to identify the names from the discussion texts in a homeopathy diagnosis discussion forum. The proposed global context-based framework is found to be effective in improving the accuracy of the named entity recognition system. https://doi.org/10.34105/j.kmel.2014.06.002


In future all-electrical ships with Medium Voltage DC distribution, the power system stability can be jeopardized by the presence of constant power loads, due to the negative impedance characteristic of their tightly regulated converters. In order to solve this problem we apply backstepping as a nonlinear control technique to the converter interfacing the generation side and which supplies the bus. In this work we demonstrate two versions of backstepping, which are compared to a centralized linearizing state feedback controller taken from literature.


Face recognition, one of the most important abilities of intelligent vision, is discussed in this paper. A new idea of model-based matching is presented. The algorithms of face modeling, global matching and fine matching are given. Finally, a robust scheme for human face rapid recognition resulted.


BACKGROUND
Laryngoscopy and tracheal intubation are an integral component of airway management and general anaesthesia. Direct stimulation of the pharynx and larynx by the laryngoscope blade and the insertion of an endotracheal tube elicit a sympathetic nervous system response with a reflex consisting of a transient increase in blood pressure, heart rate, and the occurrence of cardiac dysrhythmias referred to as the 'pressor' response. This may be of major clinical significance in patients with pre-existing systemic hypertension, hypertensive heart disease, coronary artery disease, eclampsia, aneurysmal vascular disease and head injury in whom such a change may culminate in perioperative myocardial ischaemia or infarction, cardiac failure, dysrhythmias, cerebrovascular accidents or secondary brain injury.

AIM
To evaluate and compare the effects of intravenous lidocaine and esmolol on the pressor response as well as determine the occurrence of complications with the use of either agent in a Nigerian population.

METHODOLOGY
Ninety adult ASA I and II patients undergoing elective non-cardiac surgery under general anaesthesia were randomly allocated to one of 3 groups; group E: 2mg.kg -1 esmolol, group L: 1.5mg.kg -1 lidocaine and group C: 20mls normal saline 3 minutes before laryngoscopy. Induction of anaesthesia was standardized for all patients. Heart Rate, Systolic Blood Pressure, Diastolic Blood Pressure, Mean Arterial Pressure and Rate Pressure Product were recorded at baseline, immediate post, 1, 3, 5 and 10 minutes after intubation.

RESULTS
Mean heart rate increased by 19.1%, 25.7%, and 41.4%, SBP increased 13.3%, 21.6% and 26.9%, MAP by 12.2%, 19.1% and 30.2%, RPP by 28.1%, 45.8% and 78.7% in groups E, L and C respectively post intubation. There were no complications attributable to the use of either agent.

CONCLUSION
Intravenous esmolol 2mg.kg-1 given prior to laryngoscopy is more effective than intravenous lidocaine 1.5mg.kg-1 in significantly attenuating the haemodynamic changes associated with pressure response to laryngoscopy and endotracheal intubation in normotensive patients from a Nigerian population.


During the course of law enforcement,due to being short of risk-prevention awareness,nonstandard law enforcement procedures,lacking consciousness on safety and self-assistance skills,when dealing with a common case,the police may face a serious assaulting evolved from the case which could be solved satisfactorily,like in the"3.14"case in kunming.


Persistently draining cutaneous sinuses in the region of the head and neck may present to various special ties in medicine. The etiology of such lesions varies considerably and an accurate diagnosis is a pre-requisite to ensure immediate and effective treatment. The most common etiologic factor responsible fOJ' intermittently suppurating cutaneous sinuses in the region of the head and neck is the extension of a chronic infection of odontogenic origin. The presence of a cervicofacial sinus should alert the medical and dental professions alike to the necessity of' a thorough dental examination including radiographic assessment of teeth and jaws. The following case report describes the clinical presentation, diagnosis and management of a recurrent (two year history) cervical sinus in a lO-year old boy. * Department of Dental Surgery, University of Malta, St. Luke's Hospital, Gwaramangia. ** Department of Surgery, St. Luke's Hospital, Gwaramangia. Corre,\jJolldellce: Dr M. Ciantar, Department of Dental Surgery, University of Malta, St. Luke's Hospital, Gwaramangia.


The participants of internal and international economic exchanges, the partners that compete in a market economy are always the "enterprises", no matter their name and form. In Romania after 1989, the economic legislation and practice took from other countries experience different terms to identify these participants: company, firm, economic agent, etc. The meaning of these terms has, as a rule, a different content than that devoted by Romanian commercial law to the term "enterprise". According to this, there are presented some considerations based on the Romanian and European Community's legislation that justify the necessity that the term "enterprise" regain a new content according to the dynamic of economic life and the European rules in force.


Self-diffusion coefficients of liquids are important transport coefficients which provide a basic time scale of many dynamic phenomena in liquids and in terms of which other transport coefficients can be expressed; an example for such relations is the Stokes-Einstein relation between viscosity and diffusion coefficient. For this reason considerable attention has been paid to them in the past, and efforts have been made to measure them in the literature. For the phenomenological understanding of the self-diffusion coefficients the Arrhenius activation energy theory has been often used since it sometimes provides a qualitatively correct temperature dependence in a limited range of temperature. Some years ago, Krynicki er al. [l] reported in this journal their NMR measurement of the self-diffusion cofficient of liquid nitrogen at temperatures ranging from 64 K to 98 K. They interpreted their data by means of an activation energy theory and also compared with a couple of simulation data by Barojas et al. [2] and by Cheung and Powles [3]. Their interpretation seems to yield a qualitatively reasonable result, but the nature of the activation energy is unclear as is usually the case in such a phenomenological treatment. We have recently reported on a theory of diffusion processes [4], which combines the idea of free volume theory of diffusion in liquids and the generic van der Waals equation of state [5] that provides a statistical mechanical expression for free volume required for the free volume theory of diffusion. In this theory the selfdiffusion and diffusion coefficients are expressible in a form reminiscent of the Arrhenius activation theory, but the activation energy turns out to be the work required to create a characteristic volume into which a particle can move in the process of diffusion. Thanks to the generic van der Waals equation of state that can be given a rigorous statistical mechanical representation, the work in question and therefore the self-diffusion coefficient can be calculated by means of statistical mechanics, given a model for the potential energy. This theory has been tested against experimental data


Biomass combustion can be more complicated like combustion of fossil fuels because it is necessary to solve problems with lower ash melting temperature. It can cause a lot of problems during combustion process. Chemical composition of biomass ash has great impact on sinters and slags creation in ash because it affects structure of heated ash. In this paper was solved relation between chemical composition and structure of heated ash from three types of biomass (spruce wood, miscanthus giganteus and wheat straw). Amount of SiO2, CaO, MgO, Al2O3 and K2O was determined. Structure of heated ash was optically determined after heating to 1000 °C or 1200 °C. Results demonstrated that chemical composition has strong effect on structure and color of heated ash.


Sydney is probably best known nowadays for its annual gay and lesbian mardi gras parade, beamed worldwide to millions of TV and Internet viewers, marking it as one of the iconic gay cities of the contemporary world. And while Sydney also had a reputation from its earliest convict-colony days as a city with high levels of homosexual activity—one early chief justice damned it as a "Sodom" in the South Pacific (UK, Parliament, 18 Apr. 1837, 518; question 505)—only in the last two or three decades have Sydney's homosexual or gay subcultures openly flourished and, perhaps grudgingly, been accepted. Indeed, from its earliest days until some years after World War II, Australia was in the grip of Victorian moralistic attitudes, only finally broken by the countercultural revolution of the 1960s and the social movements from the 1970s.


Summary

A range of synthetic samples of the magnetite-ulvospinel series has been made by the usual sintering technique. These samples were subjected to oxidation, and subsequent annealing treatment in vacuum. Magnetic measurements and petrological observations were made at each stage in the treatment. It is concluded that the magnetic stability of the samples is greatly increased as a result of oxidation; the TRM also increases by a considerable amount.

Some of the oxidized and annealed samples behave in an unusual manner in weak magnetic field experiments, and seem to show a novel kind of magnetic interaction.


Aim To search for a new method to produce more podophyllum substances.Methods The Sinopodophyllum emodi(Wall.)Ying endophytes were isolated by means of aseptic manipulation and identified with a standard mothod;their fermentation products were analyzed by TLC.Results 6 bacteria and 20 fungal isolates were isolated from Sinopodophyllum emodi(Wall.)Ying,in which four fungal isolates(Tc,Td,Te,Mi)could produce podophyllotoxin and two(Mh,Id)could produce podophyllotoxin-O-Glu.Conclusion The ability to produce some active ingredients which were the same or similar to the host′s was possesses by individual endophytic fungal of Sinopodophyllum emodi(Wall.)Ying.


PURPOSE
To determine quantitatively the influence of altering proliferation rates on clonal survival of asynchronously growing Chinese hamster (CHO) cells after X-irradiation and to evaluate the related contribution of alpha and beta damage.

MATERIAL AND METHODS
Cell cycle distributions at the time of X-irradiation of CHO cells were assessed by flow cytometry. Clonal radiation survival was established by colony forming assay. Survival data were fitted to the linear-quadratic model and analyzed on the basis of the mean inactivation dose, D.

RESULTS
Increased S-phases were associated with increased resistance to X-rays. Radiosensitivity as expressed by D differed by a factor of 1.6 between the most sensitive and the most resistant populations. Separately analyzing the alpha and beta coefficients of survival curves revealed that the proliferation dependent effect was correlated only with beta. The major determinant of D was alpha, but its substantial interexperimental variations were independent of the cell cycle.

CONCLUSIONS
Due to altering cell cycle distributions, considerable changes of radiosensitivity can occur. They can in part be understood as a consequence of S-phase dependent alterations of DNA damage repair. Reasons for the changes of a damage dependent lethality remain to be discovered by further research.


Abstract By cleavage of the aromatic ring of 6,7-dihydroxy-tetraline (1) with peracetic acid 1,2-bis-carboxymethylene- cyclohexane (3 a) is obtained. The addition of one mole of water to 3 a leads to 1-hydroxy-1-carboxymethyl-2-carboxymethylene-cyclohexane (4), which is readily converted to the lactone 1-hydroxy-2-carboxymethylene-cyclohexane-γ-lactone-aceticacid-(1) (5). By melting of compound 4 or 5 1,2-dihydroxy-cyclohexane-diaceticacid-1 (1,2) -di-γ-lactone (6) is obtained. 1,2-bis-carboxymethylene-cyclohexane (3 a) shows a molecular asymmetry which is of a type similar as found in atropisomeric compounds. On the basis of conformational considerations it is demonstrated that in the dilactone 6 the cyclohexane ring is stabilized in the boat form. Cleavage of the aromatic A-ring of 2-hydroxy-estradiol- (17β) -acetate (7) with peracetic acid occurs in a manner analogous to that of compound 1, giving rise to 2,3-seco-Δ10(1)-estrenediol- (5ξ, 17β)-diacid-(2,3)-lactone-(2 → 5) -17-acetate (8 a). 8 a is converted to the methylester 9 and further to the corresponding estrone derivative 11 a. Estrone-[16-14C] was incubated with the 15 000 × g supernatant from rat liver homogenate in order to investigate the possibility if scission of the aromatic ring A of estrogens is a step in their katabolism. Substance 11 a was used as a carrier in these studies


Background: Safe healthcare environments influence patients' valuation of care received and impact on better health outcomes. It has been recognized that patients can contribute invaluably in improving the quality and safety of healthcare services they receive.Objective: To explore the perspectives of patients on their safety in healthcare.Methods: A qualitative study comprising of four (4) focus group discussions (FGDs) with six to eight participants was conducted in two public health facilities in Kaduna State, Nigeria. Patients admitted in medical wards (male and female) were recruited through a purposive sampling technique after obtaining their verbal informed consent to participate. A topic guide, containing open ended questions that explored patients' opinions on their safety in healthcare was used for the discussions. All FGD sessions were recorded, transcribed and coded using thematic analysis.Results: The participants consisted of 15 females and 13 males in FGD sessions that lasted between 55 to 90 minutes. All participants were Hausa speaking, with varying levels of education. Six (6) themes were generated which the patients perceived to play a role in their safety in healthcare. These themes are: choice of hospital, patient satisfaction, patient experiences, patient engagement, communication openness and suggestions by patients for improvement.Conclusion: The findings of this study have highlighted both positive and negative perspectives of patients regarding their safety in healthcare. The patients provided some recommendations for areas where improvements are required for improved patient safety. These include infrastructural improvements, staffing, and availability of medicines, amongst others.


The mission of university can be examined from the beginning of abstract university belief to university idea,then to specific university responsibility.This process is to answer the basic issue of "what is university".Teaching and research are the basic functions of university.It is the mission and responsibility of university principal to promote teaching and research.University brings into play its function by performing its functions.University is to inherit and develop culture.The combination of inheritance and enhancement is the mission of university.The nature of education is to develop the growth of individual.


Dentinal Hypersensitivity is a relatively common painful condition described as short sharp pain usually in response to stimulus in areas of dentinal exposure.  Dentinal hypersensitivity is not life threatening, but it can be a particularly unpleasant sensation for patients dictating types of food and drinks ingested. Once sensitivity has become established the pulp may become irreversibly sensitive. Treatment is therefore aimed at not only restoring the original impermeability of the tubules by occluding them, but also controlling the neural elements within the pulp to dampen the external stimulatory effects. Mild and responsive dentinal hypersensitivity may be managed by less complex treatments such as Over the counter desensitizers and in office treatment be reserved for more severe recalcitrant cases. Clinicians should consider predisposing factors, removal of etiologic factors and dietary modifications to prevent recurrence. This article aims to inform practitioners on various management strategies for dentinal hypersensitivity.


(1982). Methods of communication exhibited by captive slender mongooses Herpestes sanguineus. South African Journal of Zoology: Vol. 17, No. 3, pp. 143-146.


complete and 42% said it was incomplete. Those who said the story was incomplete said it emphasized wrong points, lacked depth, and included too little background information, among other criticisms. Finally, news sources were questioned as to their own mass media habits. About 20% said they watch TV news "several times a day," while 42% said they watch TV news "daily," and 21% said they watch "several times weekly." Sixteen per cent said they watch TV news "occasionally," or "hardly ever." When frequency of news viewing was cross tabulated with perceived story accuracy, no significant differences were observed. Persons who reported story errors viewed TV news with about the same frequency as persons who did not report story errors. However, it should be cautioned that the number of cases in some cells of this 2 x 5 cross tabulation was very small. About SIT0 of the respondents said they get "most" of their news from newspapers; none said television, but 7% each said they get most of their news from radio or news magazines. However, about 35% of the respondents said they get most of their news from some combinutwn of mass media, and these combinations almost always included television


Seventy‐four half‐sib families of lodgepole pine (Pinus contorta ssp. latifolia Engelm.) plus trees were measured for vigour, height growth, stem diameter, wood density and ring width in two Swedish field trials at age 9. Height growth, wood density and ring width differed between families within provenances with variance components of 3–8 %. Coefficients of variation were highest for height growth and lowest for ring width. Heritabilities were similar for height growth and wood density but lower for ring width. These genetic parameters seemed to be equal for all provenances. Indirect selection for high dry stem biomass was more effective using height growth than wood density, and a correlated response in wood density of 2.1 % of mean by selecting the 15 highest parent trees was indicated. Juvenile wood density looks uncertain as a selection criterion for mature wood density.


This paper tries to find a widely accessible measure of liquidity and studies its impact on asset pricing. Using trading turnover as a measure of liquidity and the 1976-1993 Tokyo Stock Exchange data, I find that, cross-sectionally, stocks with higher turnover tend to have a lower expected return. This evidence is consistent with predictions derived from an Amihud-Mendelson type of transaction cost model in which the turnover measures investors' trading frequency. The trading frequency hypothesis also predicts that the cross-sectional expected return is a concave function of the turnover and the time-series expected return is an increasing function of the turnover. The Japanese data supports both predictions.


This paper presents a repairable system with two types of repair facilities and the failed system's repair time is arbitrarily distributed.An elementary step function is built to approximate the repair rate(μ_i x),and the semi-discretiaxtion model is presented,to provide the theory foundation for the further research of numerical calculation.


Based on ethnographic research over a two year period, this book follows and analyzes asylum appeals in the British courts. While the organization of the book reflects the formal asylum process, a focus on specific legal appeals reveals the 'political' factors as play in different institutions and actors seek to influence judicial decision-making and overturn/uphold official asylum policy.


The watermark embedded by traditional methods is easy to be lost under some attacks. To overcome this problem, this study proposes a novel method based on DWT. It adopts a digital audio watermarking state-switching system which optimizes DWT coefficients doubly. Firstly, it combines the quantization-embedding system and the weights of DWT coefficients with SNR to obtain an optimization model for watermarking. Next, the Lagrange principle, Hessian matrix, and minimum energy play three essential roles to obtain the optimal DWT coefficients and weights. Moreover, the almost invariant feature of the optimal weights holds demonstrating resistance to amplitude scaling. Compared with similar algorithms, the experimental results verify that the embedded audio in the proposed method has higher signal-to-noise ratio (SNR) and lower bit error rate (BER). At the same time, it indicates stronger robustness against various attacks, such as re-sampling, amplitude scaling, and mp3 compression.


The linear extrapolation length on the surface of an infinite plate surrouWed by mcderator is calculated using the multiple-collision methcd for the plate amd a P/sup 3/approximation for the moderator. The formulation of the problem enables the extension of the method to a higher P/sub 2 n-1/ approximation for the moderator. The results obtained by this methcd are compared numerically with those given by the application of a P/sub 2 n-1/ approximation (n = 1,2) throughout the geometry. The calculation of the flux depression in the plate is also given. (auth)


Abstract We present data on prenatal growth, development, and skeletal ossification for the Angolan free-tailed bat (Mops condylurus), a species distributed throughout sub-Saharan Africa. Specimens were measured for crown–rump length (CRL), greatest length of the skull (GLS), forearm length, mass, and wing area. We cleared and differentially stained specimens for cartilage and bone to quantify pattern of skeletogenesis. Significant regressions for general growth trajectories were generated by plotting CRL and fetal mass against GLS. We quantified growth of the forearm, which showed a positive relationship with growth of the skull. Curiously, wing area was highly positively related to fetal mass, suggesting an ecomorphological relationship of wing loading and flight ability being established early in development in this species. Patterns of ossification in this species were more similar to those of phyllostomid and pteropodid bats than they were to vespertilionid bats, to which M. condylurus is apparently more closely related.


Objective To construct a retrovirus eukaryotic expression vector pLEGFP-N1-stromal cell-derived factor-1α (SDF)- 1α that contains human SDF-1α and transfects bone marrow stromal cells (BMSCs) of rhesus, and to examine the expression of exogenous SDF- 1α and EGFP genes in BMSCs .Methods SDF-1α gene obtained from pBudce4.1-SDF-1α was recombined into pLEGFP-N1 vector to generate pLEGFP-N1-SDF-1α by use of genetic recombination techniques. pLEGFP-N1-SDF-1α packaged in virus was transfected into BMSCs of rhesus. Western blotting and immunocytochemistry were used for detection of its expression. Results The inserted gene was verified by enzyme restriction analysis, PCR and DNA sequencing. After transfected with pLEGFP-N1-SDF-1α, the BMSCs emitted green fluorescence, and expressed SDF- 1α as confirmed by Western blotting and immunocytochemistry. Conclusion After transfected to BMSCs of rhesus in virus, pLEGFP-N 1-SDF-1α may effectively express SDF-1α and EGFP,which provides evidences for auto-grafting of BMSC-SDF-1α-EGFP engineered cells in treatment of certain diseases.

Key words:
Stromal cell-derived factor-1α;  Green fluorescent proteins;  Bone marrow stroma cell;  Rhesus;  Gene therapy


When you ask colleagues why they entered medicine many say it was to help people however evidence suggests that job satisfaction is decreasing.1 Perhaps you are becoming tired and are looking for a new challenge. Well why not use your skills and become a medical volunteer.


A neuro-fuzzy system (NFS) has been developed for the prediction of K-number (K ) in a continuous wood pulp digester. The NFS architecture uses a K-means fuzzifier and a modified center-average defuzzifier for fuzzy/crisp conversion. The fuzzy rule base is determined from observed input/output data via an iterative rule-confidence matrix training algorithm, and a max-min fuzzy inference engine is used for rule interpretation. A hybrid backpropagation/genetic-algorithm training routine was developed for tuning of all membership functions. K modeling experiments were conducted on six months of observed industrial digester data at a fifteen-minute sample rate. A variable transform was developed and successfully applied to process variable representation, effectively describing the history of an input variable over a specified window of time.


Hypertension and dyslipidemia are the most significant factors-risk of cardiovascular death and are often combined with each other. During the Framingham study found that high blood pressure increases the risk of coronary heart disease by 5 times. Elevated triglycerides and LDL cholesterol increase the risk of cardiovascular complications in patients with arterial hypertension. Proved negative effect of lipid disorders and atherosclerosis on blood pressure. Both diseases are mutually influence each other A.L. Myasnikov considered atherosclerosis and hypertension as two clinical-anatomical manifestations of the unified disease. According to the Yu.V. Postnov's membrane theory, the origins of hypertension are in widespread changes in the structure and function of cell membranes, which is manifested in violation of monovalent ion transport across the cell membrane. A recent study found a significant increase in the rate of transmembrane ionotransport in patients with arterial hypertension and hypercholesterolemia.A common pathogenic basis for lipid composition of plasma and increase in blood pressure may be the change of the structure and function of cell membranes. There is no doubt that a violation of the structure and function of cell membranes, which occurs in hypertension plays one of the most important and perhaps decisive role in the development of the lipid profile, the formation of atherosclerotic vascular wall, organ damage and remodeling of the cardiovascular system.


Over the years there have been various efforts by the Central Bank of Nigeria to influence the overall performance of economy, this help the financial services sector to growth but the real sector has not grown robustly. This study therefore appraises the monetary policy regimes in Nigeria as it relates to the role of CBN policy objectives from 1986-2018, by examining the use MRR and MPR as policy instrument. The selected macroeconomic variables used are minimum rediscount rate (MRR), monetary policy rate (MPR), Output, inflation (INF), interest rate (IR), money supply (M1 &M2), and exchange rate (EXGR). The study employed the used of VAR. the result of impulse response functions shows that monetary policy has little impact during the pre central bank independence and is more effective in the post CBN independence period. Based on the empirical findings, the following recommendations were made: to successfully achieve macroeconomic objective the policy makers should continually assess the effect of policy on the economy, this will help in determining the monetary effect of policies on economy which in turn encourages growth. Moreover, money supply should also be given attention so as to assuasive inflation and improve output, above all achieve stable and sustainable growth in money aggregates. The channels of monetary policy transmission mechanisms should be monitored carefully in order to ensure that the interest rate effect prices and output in the economy.


The popularity of anime makes fans take an active role in their community, one of them is by commercializing anime fanart. The commercialization of anime fanart is rather an ambiguous problem, considering that there is no specific regulation about this matter, either in the Law No. 28 of 2014 on Copyright or Japan Copyright Act. The commercialization of anime fanart occurs because fan artists do not understand this matter. Anime fanart is a work produced by fan artist's creativity with their own style as an element of originality and differentiating them from the original creator and other fan artist's work, but on the other hand, anime fanart used pre-existing anime characters as their fanart inspiration. Fanart as a work that has elements of originality but not completely original make commercializing anime fanart an act that does not violate the rules. The purpose of this study is to compare the commercialization of anime fanart regulation between Indonesia and Japan. This study uses a normative juridical research method with a comparative law approach and a statute approach. The result of this study indicates that the commercialization of anime fanart has been implicitly regulated in Indonesia Copyright Act, as well as in Japan Copyright Act. In addition, Law No. 28 of 2014 on Copyright and Japan Copyright Act, both categorized the commercialization of anime fanart as an act of copyright infringement.


It is known that the Sobolev space $L^2_s$ with $s>n/2$ appeared in the H\"ormander multiplier theorem can be replaced by the Besov space $B^{2,1}_{n/2}$. On the other hand, the Besov space $B_{n/2}^{2,1}$ is continuously embedded in the modulation space $M^{2,1}_0$. In this paper, we consider the problem whether we can replace $B_{n/2}^{2,1}$ by $M^{2,1}_0$.


Till geochemistry and glacial geology have rarely been integrated into Yukon mineral exploration. In the Anvil District, thick glacial deposits have consistently hampered exploration. From the initial (massive sulphide) discovery in Vangorda Creek, twenty years elapsed before the Grum deposit was discovered only two kilometres to the northwest. This work examines the utility of till geochemistry as a method to trace mineralized soil/till samples back to their source rocks in the Anvil District. The Anvil District was last glaciated during the McConnell glaciation, which had a significant impact on the local terrain. The relatively swift-flowing Cordilleran ice sheet deposited thick sequences of till in low-lying areas and eroded southeast-facing slopes and hill summits in the Swim Basin and Vangorda Plateau. This type of glacial history is conducive for till geochemical exploration. A 12 km till grid was sampled northwest of the Faro deposit to map the glacial dispersion train. The till geochemistry on the –230 mesh fraction (silt and clay) indicated a broad dispersion plume for lead, zinc, and copper, extending more than 5 km west of the Faro Pb/Zn deposit. A section of the dispersion train may have a palimpsest origin. The soil geochemistry on the –80 mesh fraction, from 1964 data, indicated a much narrower dispersion plume extending directly from the Faro deposit. Till geochemistry, particularly on the fine fraction, has applications to similar drift-covered terrain, such as the Finlayson Lake massive sulphide district to the southeast.


The paper describes the components of an Integrated Furnace Control system for covered-arc (shielded arc) smelting with results from the recently started 75 MW Cerro Matoso Line 2 Furnace. The paper starts with a review of the mechanisms of power and feed input and heat losses in the shielded-arc smelting process, and describes how the details of the control system are tailored to the process. The control modules of a coveredarc smelting furnace are described including measured results and screen captures. This paper focuses on Integrated Furnace Controls tailored to shielded-arc smelting, but similar approaches have been recently applied to other furnace processes including immersed-arc smelting.


AIM:To establish GC fingerprints and standard referenced GC chromatogram for Shuanghuanglian Injection(Flos Lonicerae japonicae,Radix Scuteelariae and Fructus Forsythiae) and analyze the correlation of vola-tile components.METHODS:The volatile components of Shuanghuanglian Injection extracted by hydrodistillation were analyzed by GC and GC-MS.Similarity evaluation system for chromatographic fingerprint was applied to evalu-ating the difference.RESULTS:Fifty-four compounds were identified and 43 were classified and traced back to crude herb.Aromatic compounds as the main components,accounted for 78.11%.Terpenoids and aliphatic com-pounds were also identified,occupied 8.39% and 5.62%,respectively.CONCLUSION:The established GC fingerprint is accurate and reliable,which would be helpful in the quality control of volatile components in Shuang-huanglian Injection.


Transmit array photogrammetric camera can obtain image which is high geometric fidelity and high photogrammetric quality. However, the single chip array CCD image sensor camera can't meet the need of measuring precision and photogrammetric covering area. In order to obtain large numbers of information and extensive photogrammetric covering area, we must increase field of vision angle and improve photogrammetric covering area. And all these objects can be realized by exterior field of vision assembling photogrammetric camera. Two side work must be done before images, which obtained by exterior field of vision assembling photogrammetric camera, be used in photogrammetry. First, all assembling camera focal plane need be converted to a benchmark coordinate focal plane to realize camera digital assembling. Second, images must be re-sampled and processing. Because of coordinate conversion, two images from different assembling cameras can be established function relation, which a pixel of image from a camera is corresponding to a pixel of another image from different camera. But through this conversion, some pixels maybe extrusion together and other pixels separate on an image area. So interpolation direction finding(IDF) is used to obtain these pixels and realize image re-sampling. In this paper, the structure of exterior field of vision assembling photogrammetric camera is analyzed, and the coordinate conversion method of exterior field of vision assembling photogrammetric camera and image gray re-sampling method also can be discussed. All the works are based to data pretreatment of exterior vision assembling photogrammetric camera.


Prevalence of human cytomegalovirus DNA in scleroderma skin tissue Dear Sir, Endothelial injury, obliterative microvascular lesions and increased vascular wall thickness are present in all involved organs in systemic sclerosis (SSc). Possible viral triggers are raised, including human CMV, in view of increased levels of anti-CMV. antibodies in SSc, and the remarkable similarities between CMV vasculopathies and SSc vascular disease. In the present study, we studied the possible involvement of human CMV in SSc skin tissue. All 48 patients with SSc studied (male : female = 6 : 42, aged 31–75 years, mean 52.2 years) satisfied the criteria of the American College of Rheumatology for SSc. Thirty-one patients with SSc had limited and 17 had diffuse cutaneous disease, according to the description of LeRoy et al. Fortyseven patients with SSc were positive for antinuclear antibody, 11 for antitopoisomerase I antibody and 19 for anticentromere antibody. The mean age of SSc onset was 40.7 years (range 20–73 years). All biopsies were obtained from lesional skin (dorsal aspect of forearms). For comparison, we included 97 healthy subjects (male : female = 23 : 74, aged 24–74 years, mean 55.3 years) with no history of autoimmune diseases. All biopsies from the controls were obtained from the dorsal aspect of the forearms after informed consent. Crude DNA was extracted from skin tissue specimens with a QIAmp DNA Mini Kit (Qiagen, Hilden, Germany). PCR amplification was performed in a buffer containing 10 mmol/ l potassium chloride, 1.5 mmol/ l magnesium chloride, 100 ml/ l gelatin, 200 mmol/ l each of a four deoxynucleotide triphosphate mixture, 1.25 U/μl AmpliTaqGold polymerase (Applied Biosystems, CA, USA), and 20 pmol of the respective primers. The PCR reaction was carried out using a specifically designed primer set for cytomegalovirus DNA [5′-GAGGACAACGAAATCCTGTTGGGCA-3′ (GB1) and 5′-TCGACGGTGGAGATACTGCTGAGG-3′ (GB2)]. The temperature cycles for amplifying cytomegalovirus DNA comprised: preheating at 95 °C for 10 min, 35 cycles of 30 s of denaturing at 95 °C, 30 s of annealing at 60 °C, and 30 s of extension at 72 °C, followed by a 7-min extension at 72 °C. Ten-μL aliquots of the PCR product were fractionated by horizontal gel electrophoresis on a 1.0% agarose ethidium bromide stained gel. The chi-square test was used to evaluate the difference in occurrence rate among the groups. PCR to detect CMV DNA in the normal controls and patients with SSc showed that one of the PCR products showed a positive peak (lane 8), but that the others did not (Fig. 1). The DNA obtained was confirmed as CMV DNA by sequencing analysis. The occurrence rate of CMV DNA after PCR in SSc (4/47, 8.5%) showed no significant difference compared with that of the normal controls (5/97, 5.1%) (Table 1). Human CMV is a member of the β-herpesviridae family, being of double-stranded DNA and enveloped. Human CMV shows a predilection for microvascular endothelial cells and macrophages. In vitro infection of brain capillary endothelial cells with human CMV led to selective induction of type IV collagenase without general protease activation. Capillary obliteration, of which type IV collagenase is capable, is a distinctive feature of SSc and allograft rejection vasculopathy. A viral trigger of SSc was revised recently because two populations of patients with SSc (from Pittsburgh and Charleston) were shown to have increased levels of antibodies to CMV; a large DNA herpes virus. Accelerated neointima formation has already been indirectly associated with CMV in graft rejection and coronary artery bypass restenosis. Latent human CMV infection, frequent in adults, could be a common accelerating factor in autoimmune vasculopathy, allograft rejections, and restenosis. The results of the present study, however, indicated that the involvement of human CMV for the formation of SSc skin abnormality is questionable.


several types of research adapted to classify or diagnosis eye diseases using different classification techniques with different feature extraction techniques as well as with different eye data sets. The goal of this paper is that utilizing dataset of images of digital camera to classify external eye diseases. This dataset is categorized into four major classes depends on the part of the eye where the disease causes the problem. These classes were further subdivided into several subclasses equal to the number of diseases in that class. Colour histogram features utilized from Hue, ${\rm Min}, {\rm Max}$, Diff (HMMD) colour space were quantized non-uniformly as defined in MPEG-7 standard into 32-bins in addition to Laws texture features utilized from Sum channel of HMMD colour space extracted to be classified. The contribution of this paper is that a new classification technique which is Hierarchical Multi-label Classification (HMC) is applied. The overall prediction accuracy achieved is % 75.7142.


Full color 2.2‐inch Quarter Common Intermediate Format (QCIF) organic EL displays were developed using phosphorescent materials and low temperature poly‐Si (LTPS) technology. These displays exhibited a world record efficiency of 11cd/A at an optimized white CIE coordinate of (0.31, 0.32) with an OLED operating voltage of 6V. The current pixel structure for the 2.2‐inch display allows about 32% aperture ratios and a white peak luminance of over 300cd/m2.


Since laser beam may affect plant traits, it was used to enhance accumulation of proline in rapeseed and therefore to improve its tolerance to the salinity stress. This investigation was performed to study the effect of NaCl concen tration in irrigated water (0, 100, 200 and 300 mmol NaCl) on proline accumulation of Canola (Brassica napus L.) after laser irradiation (Red, Infra-red and Nd:YAG) at two exposure treatments. In each exposure, seeds were irradiated for three minutes once or twice by the laser set. Free proline content in leaves increased significantly by increasing of NaCl concentration. Also proline content significantly increased with irradiation by laser beam. The Red laser irradiation used once and the Nd:YAG laser used twice had the greatest effect on the proline content whereas the Infrared laser had a low effect. Double application of irradiation induced a significantly higher amount of proline in the leaves compared to only one application. This is the first report on using different lasers irradiation on proline content in a winter rapeseed.


Given an electric network Ee which has M meshes and P node‐pairs, its electric dual Ei will have P meshes and M node‐pairs and its classical mechanical analog Mf will have M + 1 nodes, M independent node‐pairs and P independent node cycles. A second mechanical system Mv, the classical analog of Ei, will have M cycles and P node‐pairs. If, for example, M = 2, P = 3, the system Ee, and Mv, analogs in the Firestone or "mobility" method, will be governed by two mesh equations, expressing that the algebraic sum of the voltages or velocities around any loop is zero; the systems Ei and Mf, also Firestone analogs, will satisfy two node equations, expressing that the algebraic sum of the currents or forces leaving any node is zero. These four sets of equations are identical, interchanging symbols suitably. The consideration of the four systems, Ee, Ei, Mv, Mf, forming a complete set, shows the advantages of the Firestone over the classical system of analogies and suggests a systematic use of duality in mechanical ...


Influence of media USAge of projection to learning result of Math, knowing the influence of media USAge of projection to student learning result of mathematics. Methods in this study with quasi-experimental methods. Samples were taken by simple random sampling from a population of 110 students by taking 60 respondents who were determined to be experimental class and control class. Data analysis using descriptive statistic method and test technique requirement of data analysis with normality test and homogeneity test. The result of the research shows that the experimental class that is using the projection media has good or higher learning result compared to control class that is using conventional media. So it can be said there is the influence of media USAge of projection to result of learning mathematics in wake up flat side room.


Overall impregnation behaviors with vinyl monomers to some leaf and needle woods and their distribution in woods are described. Attention is directed toward the observations of both the monomer uniformity in wood and fluid flow by diffusion mechanism which is one of the important processes in practical impregnation treatments of bulk wood. Diffusivity is appeared to depend on the percentage of void, but the uniformity of fluids in wood is found to be primarily limited by the nature of fluid pathways. Leaf woods show their affinities to MMA, but pines have exhibited their preferences to styrene.


Let (cid:2) S α,β g ( B n ) be a subclass of normalized biholomorphic mappings defined on the unit ball in C n , which is closely related to the starlike mappings. Firstly, we obtain the growth theorem for (cid:2) S α,β g ( B n ) . Secondly, we apply the growth theorem and a new type of the boundary Schwarz lemma to establish the distortion theorems of the Fréchet-derivative type and the Jacobi-determinant type for this subclass, and the distortion theorems with g -starlike mapping (resp. starlike mapping) are partly established also. At last, we study the Kirwan and Pell type results for the compact set of mappings which have g -parametric representation associated with a modified Roper–Suffridge extension operator, which extend some earlier related results.


Abstract
The aspiration of this essay was to search for explanations why children who are victims of sexual abuse don´t tell someone immediately about their horrifying experiences. Commonly, their way of dealing with the trauma is instead silence for many years until they decide to reveal the abuse. I have read four autobiographies written by people who were themselves, when they were children, victims of sexual abuse. Qualitative research method within the tradition of emotionalism and coding was used in the analysis of the biographies. The children´s tendency to not tell is the result of own negative emotions, part of Silvan S. Tomkins negative affect theory, as well as the surroundings inclination to reject sexual abuse of children as a children's figment of imagination because of the negative emotions it brings up. Another reason for the surrounding´s denial and lack of further report is the stigmatization revolving sexual abuse of children.


The Penn State Sports Concussion Program was initially developed by Drs. Ruben J. Echemendia and Margot Putukian in the 1990s. After both left Penn State in the early 2000s, I was asked to assume responsibility for the part of the program focusing on neuropsychology and gladly took it on. Since that time, during about the past 15 years, sports concussion has received increasingly intense research and media attention. In the past, concussions in sports were often disregarded as "dings," or "getting your bell rung." Currently, no one with even relatively casual knowledge of concussion would say these things. With Ann McKee's Boston University group recently publishing their chronic traumatic encephalopathy (CTE) study on former National Football League (NFL) players, the potential long-term impact of repeated concussions has been brought into vivid relief. Her Boston University group found that 110 of the 111 former NFL players' brains were consistent with CTE (Mez et al., 2017). With that said, acute sports concussions, although serious neurological events, if approached with knowledge and care, can often be managed well.


The study was conducted in one of the fields of Babylon province, Hilla District - Al-Wardiya area, with clay loam soil, during the autumn season of 2021 with the aim of studying the effect of using modern irrigation methods with different levels of depletion and its effect on the physical properties of the soil. The Randomized Complete Block Design (RCBD)was used according to the arrangement of the split plots and three replicates, The main plots included the treatment of depletion levels and the sub plots of irrigation systems, and the treatments were distributed on the experimental plots in a random manner. The irrigation systems included three levels of Sub-surface Drip Irrigation - surface drip irrigation - surface irrigation in furrows, and the levels of depletion for each treatment were 20%, 40% and 60%.The highest bulk density was obtained at subsurface drip irrigation plants at a drain level of 60%, and the lowest value when subsurface drip irrigation at a level of 20%. There was no significant difference between the treatments and levels studied in the experiment. The results of the statistical analysis also showed that there were no significant differences between the values of the total porosity of the studied treatments and there was no significant effect on the bi-interaction between the experimental treatments and mean weight diameter, where it reached the highest value for surface irrigation and the lowest value for subsurface drip irrigation. There was a significant effect in the values of saturated water conductivity between the experimental treatments at different levels, and it reached the highest value at I1M2.


A procedure is outlined which can be used to determine the response of an experimental sample to a single, simple broadband frequency pulse in terahertz frequency time domain spectroscopy (TDS). The advantage that accrues from this approach is that oscillations and spurious signals (arising from a variety of sources in the TDS system or from ambient water vapor) can be suppressed. In consequence, small signals (arising from the interaction of the radiation with the sample) can be more readily observed in the presence of noise. Procedures for choosing key parameters and methods for eliminating further artifacts are described. In particular, the use of input functions which are based on the binomial distribution is described. These binomial functions are used to unscramble the sample response to a simple pulse: they have sufficient flexibility to allow for variations in the spectra of different terahertz sources, some of which have low frequency as well as high frequency cutoffs. The signal processing proce...


Transactional memory is a perspective abstraction for the creating a scalable parallel programs for multi-core systems. It will be included in C++17. In this work, are proposed optimization method of conflicts detection, that accur in parallel programs with the software transactional memory during execution. The autors have implemented a module for GCC compiler for profiling parallel programs with software transactional memory and a tool for adaptive tuning runtime-library. The efficiency of method is investigated on the STAMP benchmarks.


Flexible endoscopes are complex medical devices and difficult to clean and to disinfect. Following case reports on infection transmission in endoscopy the potential risk of infection transmission was critically discussed in the past questioning the appropriateness of reprocessing practices used at that time. In a historical perspective of the last 20 years different phases were characterized, which retrospectively correspond to the plan-do-check-act- phases of a national quality management program to improve endoscope reprocessing in the physician's offices. The HYGEA-Study reveals questionable results in about 50 % of microbiological surveillance cultures of reprocessed endoscopes. Before introducing a national screening program for colon cancer by colonoscopy in 2002 agreement for a quality assurance assessment was achieved with subsequent establishment of a nationwide quality assurance system. Thereby, the reprocessing quality improved considerably and questionable results of microbiological surveillance cultures drops down nationwide to 5 %. In analogy to the quality assurance assessment for colonoscope reprocessing similar quality assurance assessments for all other endoscopic examinations should be established. The private health assurances should support this quality assurance system.


The aim of this research is to demonstrate the effect of fee audit, competence and the change of authority to auditor's motivation empirically. In this study, the research samples are Auditors working at Public Accountant Firms in Padang, Pekanbaru and Medan. The researcher used the primary data as the collection data method. There are two variables used at the research. The first variable is independent which consists of fee audit, competence and the change of authority. The second variable is dependent variable. The variable is auditor's motivation. Hypothesis is done by Multiple Regression Models. Based on the hypothesis test found that fee audit and the change of authority do not effect to the auditor's motivations significantly. From the hypothesis test phase also found that competence has a significant effect to auditor's motivation at Public Accountant Firms in Padang Pekanbaru and Medan. Keywords: Fee Audit, Competence, Auditor's Motivation Normal 0 false false false EN-US X-NONE X-NONE /* Style Definitions */
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Embedding graduate qualities or attributes, such as problem solving capacity, into program curricula requires explicit identification to students of opportunities for development and assessment of these qualities. In the University of South Australia Pharmacy program a multistage project was undertaken which firstly sought to identify student issues around problem solving ability. Secondly, in response to identified shortcomings, problem based learning was incorporated into applied pharmacotherapeutics courses. The third is the assessment of potential disadvantages to student subgroups such as non-English speaking and international students. Finally, assessment of whether students identified problem solving as an explicit process embedded in teaching methodology were undertaken. This paper reports on the successful incorporation of a problem based learning tutorial teaching modality into applied pharmacotherapeutics courses. No student subgroups were identified as being disadvantaged by the introduction of this approach.


Some students struggle with Excel and Access skills, especially in a business environment. What follows are the results of these skills being taught at a medium-sized Midwest University. While the number of Excel and Access projects provided to the student has been increased to provide greater breadth, students are still wrestling with the depth that some of the projects present. Additionally, students have a difficult time when it comes to advanced skillsets in Excel including data tables and statistical forecasting. Four classes were used for this research. Two classes used simulation training for Excel and Access projects. Two other classes did not use simulation training. The classes using simulation are being conducted so that the student must do one of the simulation projects in the classroom. It is hypothesized that the simulation classes will not only have a better overall average/project but will have a better midterm and final grade for the Microsoft Excel and Microsoft Access projects. While the students in the simulation classes did earn a higher grade on three of the most difficult projects when compared to the non-simulation classes, the midterm composite grade was about 8% higher for the non-simulation class. The simulation class did score higher on the Access midterm by over 9%. This is significant if non-equal variances were assumed.


Parathyroid hormone (PTH) increases renal calcium absorption exclusively in cortical thick limbs and distal tubules. Lack of sufficient tissue has precluded detalled biochemical study of the mechanisms responsible for the hypercalcemic effect of PTH. Therefore, we assessed PTH action on calcium transport in Madin‐Darby canine kidney (MDCK) cells, a cell line expressing distal characteristics, to determine its suitability as a model for analyzing PTH action. Calcium transport across MDCK cells grown to confluence on porous filters was measured at 37°C in Ussing chambers. Mucosal‐to‐serosal calcium fluxes (JCa, mol/min cm−2 × 10−9) were measured with 45Ca at −3, −1, 5, 10, and 20 min; agonist was added at 0 min. Basal JCa averaged 0.98. PTH at 0.2 μM increased JCa by 12% (P 0.05) and 1 μM PTH by 70% (P0.01). Calcitonin (1 μM) had no effect on JCa. The fact that high concentrations of dibutyryl cAMP (1 mM) and forskolin (10 μM) increased JCa by only 37% and 22%, respectively, suggested that cAMP‐independent mechanisms may participate in PTH‐stimulated JCa. Therefore we examined the effect of other putative second messengers. In the presence of 2 mM external [Ca], 10 nM A23187 increased JCa by 88%, and 10 μM A23187 increased JCa by 121%. Addition of 10 μM phorbol 12‐myristate 13‐acetate (PMA) increased JCa by 60%. We conclude that: (1) PTH specifically stimulates unidirectional calcium absorption in MDCK cells; (2) both adenylate cyclasecoupled and calcium‐coupled receptors may participate in signaling the response to PTH; and (3) confluent MDCK cells represent a useful experimental model for elucidating the biochemical mechanisms involved in the renal hypercalcemic action of PTH.


When the dietary intake is constant, the daily variations in serum and urinary citric acid levels are slight. In this study, during a constant dietary regimen, increased serum concentrations of 17-hydroxycorticosteroids were associated with significantly decreased serum levels and urinary excretion of citric acid. This decrease was observed prior to, or in the absence of any significant changes in calcium, potassium, sodium or acid-base balance which might otherwise explain the direction of the change in citric acid levels. The decrease also occurred despite an increase in urinary calcium excretion or an increase in potassium retention. It is postulated that 17-hydroxjrcorticosteroids depress scrum and urinary levels of citric acid as a consequence of a decrease in the conversion of pyruvic acid to acetyl-CoA (which becomes coupled with oxalo-acetic acid to form citric acid).


Type of funding sources: None.

 Paradoxical aortic stenosis (AS) is low-flow (SVi ≤ 35ml/m2) , low- gradient (Mean PG ≤ 40mmHg) severe aortic stenosis (AVA < 1cm2) in patients with preserved ejection fraction (EF ≥ 50%) usually associated with female gender, advanced age, small body size and history of hypertension. Left ventricular (LV) reverse remodeling presents with LV hypertrophy reversal following aortic valve replacement (AVR) and is associated with better long term prognosis.

 The purpose of our study was to asses echocardiographic predictors of better outcome in patients with paradoxical severe AS following AVR.

 Detailed transthoracic echocardiographic (TTE) evaluation with left ventricular strain analysis was performed using 2D Philips Epique 7 in patients with severe aortic stenosis with AVR indication before and 4 months after the intervention.

 Among 75 patients with severe AS and indication for AVR, 20 (31, 7%) were paradoxical AS with low- flow, low –gradient and preserved ejection fraction. Sixty percent were female and eighty percent had hypertension where all echocardiographic parameters improved following AVR including improvement of LV global longitudinal strain (LS) as well as reduction of left ventricular mass indicating left ventricular reverse remodeling (Figure 1). The patients with paradoxical AS compared to the other forms of severe AS had the lowest values for MAPSE and s'TDI before and after AVR. Independent predictors of LV reverse remodeling before AVR were end systolic LV volume (ESV) , AVA/BSA and the number of segments with LS < 13%.

 Paradoxical severe AS is associated with worse post AVR prognosis compared to the high gradient severe AS.  Echocardiographic predictors of LV reverse remodeling in patients with paradoxical severe AS following AVR are LV ESV, AVA/BSA and number of segments with LS < 13%. Timely diagnosis and AVR referral of patients with paradoxical severe AS is of major importance in the management of aortic valvular disease. Abstract Figure. Descriptive of 20pts with paradoxical AS  Abstract Figure. Predictors of LV reverse remodeling


In this work alloy EN AW 5083 was studied with the aim to see the influence of microstructure on hydrogen embrittlement susceptibility in as-cast and homogenized condition, respectively. Hydrogenation of tensile samples was performed by the method of electrochemical cathodic charging in solution of 0.5 M H2SO4. Tensile behaviour has shown that hydrogen has a deleterious effect on mechanical properties, predominantly on contraction Z, while yield strength and tensile strength values remain unchanged for as-cast specimens in uncharged and H-charged conditions. After single step homogenization treatment at 520°C for 8 hours, hydrogenated specimens haven't shown significant differences in tensile behaviour so that hydrogen embrittlement index HEI is comparable to the one calculated for as-cast hydrogenated specimens. The reason for this was revealed by metallographic and SEM analyses which have shown that homogenization had little effect on the grain structure as well as on type and morphology of precipitates in microstructure of EN AW 5083.


A compact Lie group G and a faithful complex representation V determine the Sato-Tate measure μG,V on C, defined as the direct image of Haar measure with respect to the character map g 7→ tr(g|V ). We give a necessary and sufficient condition for a Sato-Tate measure to be an isolated point in the set of all Sato-Tate measures, regarded as a subset of the space of distributions on C. In particular we prove that if G is connected and semisimple and V is irreducible, then μG,V is an isolated point.


An improved high-temperature superconducting maglev measurement system (SCML-01) was designed and successfully developed to further study the maglev properties of YBaCuO bulks above permanent magnets (PM) or a PM guideway. The system includes a liquid nitrogen vessel, a cylinder PM or PM guideway, a set of two-dimensional motion mechanisms, a set of three-dimensional motion mechanisms, control hardware, and control processing software. In addition to keeping the previous capabilities, the most recent improvements include an integrated measurement of displacement, temperature, force, torque, and magnetic field signals all with higher precision. In particular, the three-dimensional motion mechanism can combine any two-dimensional direction to realize some complicated curve movements, such as z-type, slant-type, and circle-type back and forth many times. These new functions have an important meaning for practical application.


In order to overcome sensitive defects of components deviations and environment defects in analog circuit design, a novel four-dimensional hyperchaotic systems is constructed based on LU system. Basic nonlinear dynamics characteristics are analyzed to the new system. By optimizing the design of sampling frequency selection, gain adjustments, parameter configuration etc., the hyperchaotic circuit runs stably while the signal amplitude is reasonably controlled. Curves of the digital chaotic sequence show smooth without jagged shape. The circuit can be applied to other digital realization of chaotic systems with commonality and expandability. Its experimental results fully consistent with phase space structures of the continuous chaotic system, which shows the development of chaotic systems based on FPGA is feasible and practical. DOI:  http://dx.doi.org/10.11591/telkomnika.v11i5.2503 Full Text: PDF


Isobutane alkylation is a typical carbocation chain growth reaction that requires proper acidity with less acidity change for its enhanced lifetime and activity of the catalyst. In this work, a family of protic ionic liquid/triflic acid as synergistic catalysts has been developed for isobutane alkylation, with special emphasis on its reusability. The slowest acidity change was found with varied concentrations of triflic acid for the protic ionic liquids which is probably buffered by binding and releasing the solubilized acid in the formed anionic cluster [N222H][CF3SO3(CF3SO3H)x] as indicated by FT-IR and 1H NMR spectroscopy. As a promising isobutane alkylation catalyst, the protic ionic liquids have shown a maximum selectivity toward C8 up to 86.23%, research octane number (RON) up to 97.3, and reusability up to 36 runs, outclassing the sulfuric acid or triflic acid catalysts under the same reaction conditions. Apart from the excellent catalytic performance, the new catalytic system showed better impurit...


We have shown previously that the Ca channel b3 subunit is capable of modulating tonic G-protein inhibition of a1A and a1B Ca channels expressed in oocytes. Here we determine the modulatory effect of the Ca channel b3 subunit on M2 muscarinic receptor-activated G-protein inhibition and whether the b3 subunit modulates the G-protein sensitivity of a1A and a1B currents equivalently. To compare the relative inhibition by muscarinic activation, we have used successive ACh applications to remove the large tonic inhibition of these channels. We show that the resulting rebound potentiation results entirely from the loss of tonic G-protein inhibition; although the currents are temporarily relieved of tonic inhibition, they are still capable of undergoing inhibition through the muscarinic pathway. Using this rebound protocol, we demonstrate that the inhibition of peak current amplitude produced by M2 receptor activation is similar for a1A and a1B calcium currents. However, the contribution of the voltage-dependent component of inhibition, characterized by reduced inhibition at very depolarized voltage steps and the relief of inhibition by depolarizing prepulses, was slightly greater for the a1B current than for the a1A current. After co-expression of the b3 subunit, the sensitivity to M2 receptorinduced G-protein inhibition was reduced for both a1A and a1B currents; however, the reduction was significantly greater for a1A currents. Additionally, the difference in the voltage dependence of inhibition of a1A and a1B currents was heightened after co-expression of the Ca channel b3 subunit. Such differential modulation of sensitivity to G-protein modulation may be important for fine tuning release in neurons that contain both of these Ca channels.


INTRODUCTION. Actinomycin D (AD) is a common DNA-damaging agent. We have recently reported that AD-induced apoptosis in human megakaryoblastic leukemia cell line CMK-7 was greatly accelerated by concomitantly added colcemid (CL), a cytoskeletondamaging agent (1). The present work was conducted to investigate the synergistic enhancement of apoptosis by the combination of three different DNA-damaging agents AD, etoposide (VP-16) and mitomycin C (MMC) with cytoskeleton-damaging agents colcemid (CL), cytochalasin D (CD) and vinblastin (Vin) in different human tumor cell lines.