Provided is a method for processing a mixture containing HCl, H2O, and siloxane in the presence of packing comprising polyvinyl fluoride, which increases the stability of packing. The method for processing a mixture containing HCl, H2O, and siloxane is performed in the presence of packing comprising polyvinyl fluoride. The polyvinyl fluoride has a structural unit of the following formula 1. In the formula 1, R is hydrogen or fluorine and n has a value greater than 100. The polyvinyl fluoride is selected from polyvinylidine fluoride and polytetrafluoroethylene. The reaction is carried out at 70-200‹C.


In view of the importance of quality,progress and cost control to construction project the interrelationships among those three factors are pointed out.Detailed discussion is also made on the question that how to increase engineering quality,reduce time limit and cost control,in order to fine the optimum management and control method to create excellent project with high quality and benefits.


Abstract It is frequently necessary to combine the information provided by summary statistics for different observation sets, particularly in the context of group decision processes. Problems arise when there are unidentified observations that overlap, that is, belong to more than one set. This article discusses the handling of these problems in relation to a Normal example when the exact extent of overlap is known.


Complex system simulation has been playing an irreplaceable role in understanding, predicting, and controlling diverse complex systems. In the past few decades, the multi-scale simulation technique has drawn increasing attention for its remarkable ability to overcome the challenges of complex system simulation with unknown mechanisms and expensive computational costs. In this survey, we will systematically review the literature on multi-scale simulation of complex systems from the perspective of knowledge and data. Firstly, we will present background knowledge about simulating complex system simulation and the scales in complex systems. Then, we divide the main objectives of multi-scale modeling and simulation into five categories by considering scenarios with clear scale and scenarios with unclear scale, respectively. After summarizing the general methods for multi-scale simulation based on the clues of knowledge and data, we introduce the adopted methods to achieve different objectives. Finally, we introduce the applications of multi-scale simulation in typical matter systems and social systems.


Background: The survival in neonates is associated with their birth weights, gestation, and severity of illness. Despite all the efforts, the early neonatal mortality represents quite a high percentage. Objectives: The objectives of the study were to study the various short-term outcomes in with very low birth weight (VLBW) neonates. Materials and Methods: An observational hospital-based prospective cohort study was performed on live VLBW neonates admitted over a period of 1 year at the NICU of a tertiary hospital of Central India. Neonates with birth weight outside the study range or with major congenital anomalies and those with clinically identified chromosomal syndromes were excluded from the study. The hospital records of all neonates enrolled in the study were followed daily until the time of discharge for any morbidity. Results: A total of 116 neonates were recruited according to inclusion and exclusion criteria. There were 63 (54.3%) male and 53 (45.7%) female neonates considered in the study. The mean birth weight of VLBW neonates was 1282±136 g. Birth asphyxia was observed in 21% of the patients. Neonatal hyperbilirubinemia was the most common (36%) morbidity in these neonates. Conclusion: Almost half of the newborns had sepsis. Due to many factors such as optimization of neonatal care, better knowledge of the pathophysiology of the premature infant, the advent of exogenous surfactant therapy, and neonatal intensive care unit to handle sick infants, the survival rate in VLBW babies was higher in our study.


Electro-optic phase shifter employing BSTO electric-optic materials are much betterperformance as compared with ferrite phase shifter and phased array antennas have paid close attention to the electro-optic phase shifters, because they have high power handling capacity, highphase shifting speeds, low insert losses, low drive power,full temperature range of operation andlow cost.BSTO electro-optic materials and the methods of preparation are introduced in this paper. First, progresses are briefly outlined in the fields of the material research;Second, chemicalcomposition and preparation technique of the materials as well as effect of the non-ferroelectricphases on the properties of the materials are discussed;Finally,this paper describes some suggestions involing the direction of this material development.


Purpose
To be successful, brands should incorporate diversity in their advertising strategy. One way is to demonstrate their support for the LGBTQI community in mainstream media. This study aims to examine situational factors that affect the responses to gay presenters in mainstream media.

Design/methodology/approach
Two experimental studies were conducted in a 2 (luxury vs value brand) × 2 (gay vs heterosexual presenters) between-subjects design. Study 1 explores the interaction effects, whereas Study 2 introduces perceived congruence between the presenters and the product as a mediator.

Findings
The results show that using gay presenters in luxury brand ads leads to a more positive attitude toward the advertisement and higher product evaluation than using heterosexual presenters, whereas using heterosexual presenters to represent a value brand leads to a higher attitude and product evaluation than using gay presenters.

Practical implications
Nowadays, there is a greater need for inclusiveness and diversity in advertising. Brands need to pay attention to various underrepresented groups and adapt their strategy accordingly. This study shows that in appropriate situations, gay presenters can improve the image of a brand among heterosexual as well as gay consumers.

Originality/value
Expanding the match-up hypothesis theory, this work shows that a match can include not just an individual endorser but also the social category the endorser represents and stereotypical beliefs associated with that group.


artificial hole digging pile in bridge foundation is a type of pile foundation commonly used,the pile foundation construction quality is objectivity.This paper introduces the emergency processing methods of manual hole digging pile under special strata,as well as several key points for construction,in the treatment process with special attention to.


This paper introduces the significance and charging quantity of the ammonium nitrate explosive, and the facilities used for this kind of explosive.


With the continuous development of technology, the design of the environment can be simulated by computer technology. The virtual reality (VR) technology can be used to take the real world as a three-dimensional space, three-dimensional space can be designed to simulate the actual environment. In this paper, virtual reality technology is applied to design, and design is divided into two fields, namely landscape design and scene lighting rendering. We study characteristics of virtual reality technology and framework of virtual reality technology, at the same time, we define the concept of light and the concept of landscape in design, and analyze the problem of lighting rendering and the problem of landscape design. From the perspective of landscape design, we discuss the difficulties of virtual reality-landscape design, and further analyze the landscape design level and multi environment elements display based on virtual reality technology, and propose a feasible virtual reality-landscape design method; from the perspective of light rendering, the principle of lighting tracking algorithm can be analysised, the realized method is used for lighting rendering, the game engine is used as the rendering engine, MAYA and Photoshop software are used as the main rendering techniques of virtual reality, therefore, the real-time rendering of landscape's surrounding environment is realized.


The operational staff of the National Weather Service (NWS) Weather Forecast Office (WFO) in Charleston, South Carolina issues severe weather warnings for 20 counties in eastern South Carolina and Georgia (Fig 1). New technologies, such as the AWIPS (Advanced Weather Interactive Processing System) and the WSR-88D (Weather Surveillance Radar-1988 Doppler) has enhanced the analysis of the potential for, and occurrence of, severe weather. The forecast process employed by local forecast offices and the Storm Prediction Center (SPC) of the National Centers for Environmental Prediction (NCEP), depends upon the scientific evaluation of the evolving pre-storm environment, severe weather pattern recognition, and climatology (Johns and Doswell 1992). This study provides one of these necessary tools, a detailed severe weather climatology for the Charleston, SC, County Warning Area (CWA).


One kind of spinning machine having a multi-stage drawing means (13) and a condensate cotton with subsequent suction roll (25) and reverse roller (26, 27), and connected to a ring spinning apparatus (17). A deflector screen (40) in the region of distance (15) produces coacervation of the outer surface of the suction roll it (25) is at a distance A. In the case where the traverse device (42), the beginning of the suction zone (33) has a distance greater than the width of the traverse, followed by suction zone (33) tapering in the conveying direction.


Since the end of the 1990s, increasingly more states in the US have proposed introducing or lengthening the separation/waiting periods required for divorce as a policy tool to strengthen marriage and discourage divorce. I use the variation in the timing of states' implementation of shortened waiting periods for divorce to analyze the effects of divorce waiting periods on remarriage. I find remarriage rates to decrease among younger age cohorts but increase among their older counterparts when the waiting period is reduced to 1.5 years or less. To the extent that remarriage is an important route for aging women impoverished by divorce to recover their economic and emotional wellbeing, the results suggest that while introducing a cooling-off period for divorce might allow for the preservation of some marriages, a lengthy separation period could also harm older divorced women by hampering their remarriage prospects.


The statistical treatment of failure data and historical information about in-service network is carried out,and the failure modes are analyzed.The fault tree of the network is established,the reliability and the mode importance of the network are solved by Monte Carlo method,and the simulation error is calculated.


The authors would like to draw the reader's attention to an error in the following article: Halder A, Sommerville J, Gandhi M. Primary lymphoepthelial carcinoma of the parotid gland, pictorial review of a rare entity. J Med Imaging Radiat Oncol 2018; 62: 355–60. 'lymphoepthelial' should have been spelt as 'lymphoepithelial' in the title. The authors apologize for the error and any confusion it may have caused.


Wireless sensor network comprises of sensor nodes. Sensor nodes mainly rely on battery power which cannot be recharged in most of the situations .Thus energy of sensor nodes is a main constraint in wireless sensor network. Algorithms are developing now a day to maintain energy efficient data routing and to reduce the delay in wireless sensor network. In this paper an idea is given about various methods used in certain algorithms which can efficiently constructs a back bone virtually using connected dominating set concepts.


Three-dimensional (3D) NAND flash memory has high capacity and cell storage density by using the multi-bit technology and vertical stack architecture, but degrading data reliability due to high raw bit error rates (RBER) caused by program/erase (P/E) cycles and retention periods. Low-density parity-check (LDPC) codes become more popular error-correcting technologies to improve data reliability due to strong error correction capability, but introducing more decoding iterations at higher RBER. To reduce decoding iterations, this paper proposes BeLDPC: bit errors aware adaptive rate LDPC codes for 3D triple-level cell (TLC) NAND flash memory. Firstly, bit error characteristics in 3D charge trap TLC NAND flash memory are studied on a real FPGA testing platform, including asymmetric bit flipping and temporal locality of bit errors. Then, based on these characteristics, a high-efficiency LDPC code is designed. Experimental results show BeLDPC can reduce decoding iterations under different P/E cycles and retention periods.


Two stimuli, both dating to 2002, drove me to write this paper. The first (and by far the more visceral) was my attendance at the biannual conference of American Renaissance ( AR )—the flagship publication of the sector of the American far right considered herein. The conference was held in the Washington, D.C. suburb of Herndon, Virginia, and it reflected this demographic. It was attended by some 250 mostly well-dressed, mostly middle-aged white men—along with a smattering of women—a number of whom held advanced degrees of one flavor or another. There is nothing too surprising in this: the ignorant redneck stereotype of the racist right has always been more hopeful polemic than reality. Unfortunately, doctrinaire racists come in all income and education brackets. If bigots with Ph.D.s are nothing new, I still walked away from the conference convinced that I had seen an important new trend in what I will call American white nationalism. The second (and more academic) of the two stimuli driving me to write this paper was the publication of Carol M. Swain's book The New White Nationalism in America: Its Challenge to Integration (2002). The first book-length scholarly work to deal with the American racist right as a whole to be published in many seasons, Swain's is an important if a deeply flawed text. In this work Swain (correctly) points out that there is something new about the contemporary racist right. She also cogently warns the American political mainstream, conservative and liberal, that the phenome-non both refer to as white nationalism "has the potential for considerable expansion beyond its present scope and threatens to disrupt the fragile racial situation in America" (Swain 2002, 1).


Rafael Khachaturian is a Lecturer at the University of Pennsylvania's Critical Writing Program, and Associate Faculty with the Brooklyn Institute for Social Research. His current research examines the intersection of theories of democracy and the state within the history of the social sciences. His work has previously appeared in Political Research Quarterly, Contemporary Political Theory, Polity, and Historical Materialism.


There are two types of Phase Change Materials (PCMs) which have been developed and adopted in textiles: heat (energy released) and cool (energy absorbed). This paper discusses current PCM applications in gloves and explores future usage. Laboratory research design was used to explore the application of PCM in the design of protective gloves to determine if there was improved thermal regulation. Prototype gloves were developed using a 35% cotton/65% polyester blend interlock material which comprised of a top and bottom layer. The middle layer was a coated PCM fabric. A final layer using PANEX, a weave carbon fabric, surrounded the other layers and formed the outer shell of the glove. Preliminary tests indicate that absorbency or release of heat (energy) while changing states within this glove structure will provide a benefit for the wearer. Future research will test these gloves in working conditions.


An international scientific conference was held in December, 1958, in MOSCOW, devoted to the criticism of modern anti-Marxist economic theories. Professors, instructors and post-graduate students of the institutions of higher learning of union republics, learned scientific research institutes (the Institute of World Economics and International Relations of the AS USSR, the Institute of Economics of the AS USSR, the Academy of Social Sciences attached to the CC CPSU, and others) and representatives of several journals took part in the work of the conference. 27 reports were heard, and 46 conference members delivered discussions on them.


In the conditions of economic crisis, social instability and unbalanced, personality of development worker, being in rapid development of innovative changes and dynamic changes, needs an excessive calmness, to harmoniousness in own "I", and also moderate thinking and others like that. Self understanding itself, own overvalue of the advantages and defects, abilities of itself to reconstruct on other (informatively-innovative) format, the use of various technologies, technician, methodologies of social aspiration, allow to the development worker more carefully to carry out professional duties, adhere to the clear standards and rules of behavior in the work. Personality of emotional (positive) comfort and psychological prosperity is sensitive on own difficulties, flexibly to think, to analyze the given information, and finally she becomes more "hard-tempered", by a bar to the modern social problems, calls of present time. Strictly speaking, personality of social sphere has the opportunity during the career to be enriched, namely motivational, intellectually, effectively, emotionally, that directly correlates with capabilities, aspirations, desires and determine professional success.
Scientists, in particular І. Matekiv interpreted definition of emotional competence as willingness and ability of man flexibly to manage emotional reactions: own and other people, adequately to the situations and terms that change. From the point of view of М.Orap, emotional firmness of child or adult it can be determined as ability deservingly to feel, to be happy, successful in the sphere, to surmount certain obstacles, if will own certain skills of the psychological state.
At the same time G. Seli, distinguishes such stress is factor that is related to organization and maintenance of professional activity of personality: excessive overload, psychical activity or obvious underloading is tense in the volume of executable work; monotony or complication of executable work; increase responsibility; necessity to accept too many decisions; absence or "small" participation is in the process of making decision; novelty, reorganization at work; uneffective organization of workplace; change of duration or terms of labour; physical factors (temperature, noise, populousness); sudden or systematic distraction of attention (unexpected irritants or permanent influence of obstacles and, as a result, development of premature tiredness); disturbance by the consequences of erroneous actions, to do fear error
Every specialist of the business must understand and realize what resources can use, namely to what active forms it can be succeeded: co-operating with positive people (parents, colleagues, relatives, and acquaintances), hobby, interests, interesting businesses, pleasant leisure, and also active motivation of overcoming and others like that.


7337 Background: Cyclooxigenase-2 (COX-2) is overexpressed in about 70% of NSCLC. Selective inhibitors of COX-2 have antitumor activity by blocking angiogenesis and apoptosis. The different mechanisms of action and the non-overlapping side effects suggest their association with cytotoxic agents. This Phase II study was designed to evaluate the activity and tolerability of weekly paclitaxel (PCT) plus celecoxib (CEL), and possible clinical correlations with biomarkers. Methods: PCT was administered at the dose of 80 mg/m2 IV weekly for six weeks followed by two-week rest, and CEL 400 mg p.o. bid continuously. A cycle consisted of 8 weeks. Serum/CTADplasma VEGF and IL-6 analysis was performed at baseline and every two cycles. Results: 53 patients (pts), previously treated with front-line platinum-based chemotherapy, entered the trial since January 2002. None of them had previously received taxanes. Pts characteristics: median (m) age 60 yrs (range 30–77); male/female= 43/10; PS 0/1/2= 31/20/2; 30 adenocarci...


Tremor was the first movement disorder ever described and is mentioned in medical literature, with variable terminology, since Hippocrates' writings. The current term derives from the Proto-IndoEuropean root *ter-, meaning to shake and to fear, that was retained with its double meaning in Sanskrit and in ancient Greek after undergoing a syllabic metathesis: =lfr (trasat), sqE lx (tr em o, to tremble or to shake), sqόlo1 (tr omos, shaking caused by great fear). The two meanings became for the first time distinct in Latin, as the original *terroot was retained to mean having fear (terreo; see English: terror), whereas the *tremetathesis referred specifically to the involuntary movement of tremor. This language evolution also accompanied medical interest: Galen, who practiced under the Roman empire, dedicated a detailed monograph to tremor that he considered a phenomenological entity distinguished from any other hyperkinetic condition, specifically palpitations and spasms (considered early descriptions of dystonia). Notwithstanding such a long history of detailed observations and distinctions, the classification of tremors remains a challenging task. The IPMDS task force on tremor recently proposed a new consensus where tremors are classified along two axes: clinical characteristics and etiology. At first sight, this new classification recalls the recent classification of dystonia that is also organized in two axes with identical names. However, there are significant differences. First, Axis I in the tremor classification includes laboratory tests, whereas in the classification of dystonia Axis I only includes physical examination and medical history. The difference is understandable, since tremor is the clinical expression of an oscillation, whose characteristics (e.g. frequency, amplitude, etc.) can be measured in a neurophysiology or movement disorders lab. Other laboratory findings, such as structural imaging, are also listed under Axis I. By contrast, in the dystonia classification, nervous system pathology (including imaging) has a dedicated listing under Axis II (etiology) and other lab tests are not mentioned. The dystonia classification had to accommodate the terminological heritage of "primary dystonia", a term used until recently as a combined phenomenological and etiological descriptor for "genetic or idiopathic cases in which dystonia is isolated and there is no consistent pathologic change". Therefore, the dystonia task force felt it was important to retain an etiological entry listing pathological changes under Axis II. To this respect, the dystonia classification is backward compatible: former "primary dystonia" is now called "idiopathic isolated" or "inherited isolated", depending on the genetic status. A second difference between the two classifications is that, for tremor, common syndromic aggregations were outlined as part of the classification exercise. By contrast, the dystonia classification did not list dystonia syndromes, that were the object of an independent publication. A reason for such difference is the historical heritage of "essential tremor", a syndrome with variable definitions over time that needed systematization. In that respect, the new classification of tremors is backward compatible, accommodates and updates earlier descriptions of essential tremor, and recognizes two distinct syndromes: "essential tremor" and "essential tremor plus". Experts on dystonia, who succeeded to get rid of the "plus" descriptor used in earlier dystonia classifications, may not be happy to read this. Notwithstanding, there are substantial advances in the new definitions of essential tremor, the most common syndrome of isolated tremor, and the exclusion criteria are also very useful to highlight what is not essential tremor. These innovations pave the way for the common language needed to make advances in knowledge, the main purpose of any classification. The interrelation of tremor and dystonia, observed since the time of Galen, still remains a fascinating clinical and pathophysiological relationship. A subtle red line further connects the dystonia and tremor classifications: what is the minimal requirement for making a diagnosis of dystonia? In other words, are any of the -------------------------------------------------------------There are no relevant financial disclosures related to this letter.


We have searched for redshifted neutral hydrogen 21cm absorption toward sources from the Stickel et al. (1996a) 'red quasar' sub-sample. The red quasar sub-sample is taken from the 1 Jy sample of flat spectrum radio sources, and is comprised of the 15 sources which are undetected on the POSS. Five of these red quasars have been searched for redshifted HI 21cm absorption to optical depth levels of a few percent, and four show strong absorption, with neutral hydrogen column densities between 4 and 80×10 18 ×(Ts f) cm −2. This 80% success rate for the red quasars compares to the much lower success rate of only 11% for detecting HI 21cm absorption associated with optically selected Mg II absorption line systems (Briggs and Wolfe 1983, Lane et al. 1997). The large neutral hydrogen column densities seen toward the Stickel et al. red quasars provide circumstantial evidence supporting the dust reddening hypothesis, as opposed to an intrinsically red spectrum for the AGN emission mechanism. The lower limits to rest frame values of A V are between 2 and 7, leading to lower limits to the spin temperatures for the neutral hydrogen between 50 K and 1000 K, assuming a Galactic dust-togas ratio. We consider the question of biases in optically selected samples of quasars due to dust obscuration. Overall, the data on the red quasar sub-sample support the models of Fall and Pei (1993) for dust obscuration by damped Lyα absorption line systems, and suggest that: (i) there may be a significant, but not dominant, population of quasars missing from optically selected samples due to dust obscuration, perhaps as high as 20% at the POSS limit for an optical sample with a redshift distribution similar to the 1 Jy, flat spectrum quasar sample, and (ii) optically selected samples may miss about half the high column density quasar absorption line systems. – 3 – The redshifted HI 21cm absorption line detections presented herein are toward the sources: 0108+388 at z = 0.6685, 0500+019 at z = 0.5846, and 1504+377 at z = 0.6733. No absorption is seen toward 2149+056 at z = 0.740 at a level below that seen for the three detections, although there is some uncertainty in this case as to the expected line redshift. In some systems the absorbing gas is in the vicinity of the AGN, either circumnuclear material or material in the general ISM of the AGN's …


An optical feedback scheme is proposed and demonstrated to reduce the phase noise of a passive mode-locked laser diode. A minimum RF linewidth of 354 Hz and timing jitter of 220 fs is obtained.


It is well known that the isolated word recognition strategy based on pattern matching gives good performance; however, in order to achieve efficient implementation it is necessary to develop techniques to reduce computational complexity and memory requirements, especially when the vocabulary size is not very small. In this work three different pattern compression techniques are compared on the basis of efficiency as well as recognition performance when applied to pattern matching by means of dynamic programming in a speaker dependent context.


D-Lactic acid can be produced by either chemical or biochemical methods and is an important raw material or intermediate used in many fields including pesticides and herbicides production, and as polymers with promising applications in medical areas. Esterase produced by Rhizopus sp. WS0128 was effective in the catalytic resolution of racemic ethyl lactate to produce optically pure D-lactic acid. The cells of Rhizopus sp. WS0128 were immobilized by entrapping them into calcium alginate gels, and the fermentation of the immobilized cells was carried out in an external-loop airlift bioreactor (ELAB) (11.5 l). Optimal growth conditions for the microorganism were determined such that the maximum esterase activity of the immobilized cells reached 57.9 U/g cells after 48 h of fermentation. The immobilized cells of Rhizopus sp. WS0128 containing abundant esterase could be used directly as a biocatalyst in the enantioselective hydrolysis of ethyl lactate. The optimal hydrolysis reaction conditions were initial substrate concentration 160 g/l, temperature 40 °C, pH value 7.5 and reaction time 3.5 h. Under these conditions, the hydrolysis yield of ethyl lactate was 43.4% and the optical purity of D-lactic acid was 96.3%. The immobilized cells were quite stable and could be utilized repeatedly in the biocatalytic process for at least six batches, where the average hydrolysis yield of ethyl lactate and the average optical purity of D-lactic acid were 43.1% and 95.9%, respectively. This research work showed a promising process of D-lactic acid preparation by biotransformation. Copyright © 2010 Curtin University of Technology and John Wiley & Sons, Ltd.


The United Kingdom was the first to introduce the prohibition for companies to give financial assistance for the purchase of their shares. I was also one of the first to produce legislation ameliorating the problems created by such a prohibition. This study of Commonwealth jurisdictions around the Pacific Rim illustrates the extent to which the prohibition of financial assistance was mirrored. Commonwealth legislatures on the Pacific Rim provide a useful range of legislative responses in this regard. Some appear not to recognise any problem exists with financial assistance; some others have produced workable legislation protecting the interests of the company and shareholders but may not provide adequate protection for creditors, and so on. This article considers the difficulties experienced by jurisdictions in extricating themselves from the original prohibition, as well as some attempts to develop practical solutions to the financial assistance problem. It also queries whether adequate regard is given to the interests of creditors.


Collective Labor Agreement is an agreement which is the result of negotiations between trade unions / labor unions or several trade unions / labor unions which are registered with the agency responsible with the employer. The problems that occur in the implementation of a collective labor agreement on working time at the Head Office of PT Perkebunan Nusantara V in Pekanbaru city no longer use the overtime work system and overtime wages in accordance with Undang-Undang number 13 of 2003 concerning Employment and Decree of the Ministry of Manpower and Transmigration Number: KEP-102 / MEN / VI / 2004 concerning overtime work and overtime wages, so that workers who work overtime will get overtime compensation, namely transitional allowances. But in the implementation of the transition allowance given to all the executive employees in IA-IID group. In this study the authors raised two formula of the problem, namely how the implementation of the Collective Labor Agreement on Working Time at the Head Office of PT Perkebunan Nusantara V in Pekanbaru city and What are the obstacles in the Collective Labor agreement on working time at the Head Office of PT Perkebunan Nusantara V in Pekanbaru City. The research method used in this research is observational research, which is a type of research that takes samples from the population by using interviews as a basic data collection tool. Research that is descriptive analytical is research that intends to make a description of the situations or events. And can provide an overview of the Implementation of Collective Labor Agreement on Working Time at the Head Office of PT Perkebunan Nusantara V in Pekanbaru City. Data analysis in this study was carried out qualitatively and quantitatively, while conclusions were made deductively. The results of the research and discussion in this study are about working time, overtime work, transitional allowances and obstacles in implementing Collective Labor Agreements about working time at the Head Office of PT Perkebunan Nusantara V. Regarding the regulation of work time at the head office of PT Perkebunan Nusantara V in Pekanbaru city has been in accordance with Undang-Undang number 13 of 2003 concerning employment. And in the implementation of overtime and transitional allowance, PT Perkebunan Nusantara V no longer uses the overtime work system in accordance with Undang-Undang number 13 of 2003 concerning Employment and Decree of the Ministry of Manpower and Transmigration Number: KEP-102 / MEN / VI / 2004 concerning overtime work and wages for overtime work, therefore the agreement between the company and trade unions overtime system is replaced with a transitional allowance system.


The objective of this paper is to open a discussion within the workshop regarding the particularities of recommendations in the eLearning domain. In particular, in the context of learning management systems (LMS) that support inclusive scenarios, we aim to discuss the utility of an authoring tool for teachers to manage the recommendations provided by the LMS to students. The objective of this tool is twofold: 1) to facilitate the involvement of teachers in the process of understanding the needs of users when providing recommendations in the eLearning domain, and 2) to offer teachers a control mechanism on what is recommended to users.


The invention discloses an evaporation technology of a metalized safety thin film of a capacitor. The evaporation technology comprises the following steps that a first metal coating is evaporated on one face of a middle thin film substrate; the first metal coating is covered with a layer of first thin film medium; the middle thin film substrate and the first thin film medium are closely attached; a second metal coating is evaporated on the other face of the middle thin film substrate; the second metal coating is covered with a layer of second thin film medium; the middle thin film substrate and the second thin film medium are closely attached; each of the first metal coating and the second metal coating is aluminum or zinc or a mixture of aluminum and zinc; and the middle thin film substrate, the first thin film medium and the second thin film medium are each made of a polyolefin material. According to the evaporation technology of the metalized safety thin film of the capacitor, the requirement of the metalized thin film of the capacitor for the preparing technology can be reduced, and the actual use requirement can be met.


ABSTRACT Bubble dynamics and site interaction are studied numerically by solving conservation of mass, momentum, and energy equations for the liquid and vapor phases. The liquid-vapor interface is tracked by a volume of fluid method. The effects of applied mean heat flux, site-site interactions, orientation of the boiling surface, inclination of nucleating tunnels, and reentrant cavity shape on the bubble dynamics are investigated. With the increase of mean heat flux three separate regimes namely surface tension driven interaction, no interaction and instability driven interaction between the bubbles were shown. Closer nucleation sites fascilitates bubble merging whereas sites away from each other behaves like individual bubble release. Critical spacing between the sites are predicted bifurcating interaction and no interaction zones separately. Site-site interaction patterns are also tested on inclined planes and critical inclination angle has been reported beyond which columnar bubble formation is observed as a result of merging. Using numerical simulation efforts have been also made to check suitability of site inclination and base pocket at the end of the tunnel to generate high heat transfer coefficient. Proposal of reentrant cavity base geometry matches well with literature.


The phosphatidylinositide 3-kinases (PI3Ks) have emerged as important therapeutic targets for the treatment of hematological malignancies and solid tumors. In hematological cancer therapy, the majority of clinical activity has centered on the inhibition of the class IA isoform p110δ and the class IB enzyme p110γ, whereas for solid tumor treatment the landscape has been dominated by inhibitors of all four class I PI3Ks (p110α, β, δ and γ) or dual class I/mTOR inhibitors of limited selectivity. Our research has focused on the emerging role of p110β and p110δ in both cancer types, in which overexpression, mutation and PTEN-defectiveness have been shown to be key features in disease pathogenesis and progression. We have designed and developed a uniquely selective series of small molecules that inhibit the p110β/δ isoforms, and which display extremely high specificity in the human kinome. The design of such molecules has enabled us to interrogate the function of p110δ in tumor immunotherapy and p110β in primary tumor growth and metastasis; our lead compounds show promising oral activity in syngeneic models, in which they inhibit tumor growth and metastatic spread whilst also impacting on downstream biomarker responses. Additionally, through our ability to tune selectivity over p110α and p110γ, elimination of the mechanism-related toxicities associated with those isoforms can be realized, making selective dual p110β/δ inhibition potentially more conducive to combination therapy than for pan-PI3K inhibitors. Described herein is data for our clinical development candidate, KA2237, which is an orally-active, potent and selective p110β/δ inhibitor. This molecule displays potent in vitro growth inhibition and PD responses in a spectrum of hematological tumor lines, including in MCL and PTEN-null GCB-DLBCL, and has potential to treat BTK inhibitor-resistant malignancies of the hematopoietic system. KA2237 will enter Phase I studies in hematological cancer at the end of 2015. Disclosures No relevant conflicts of interest to declare.


Based on the existing prblem of test of higher vocational students,the paper analyzes principle,conet,time and method of project teaching of higher vocation student.


This year will see hundreds of events worldwide— large and small—celebrating the 100th anniversary of Alan Turing's birth and raising awareness of Turing, his contributions, and the fundamental importance of computing and computer science. At ACM we had a long discussion of how best to mark this special anniversary and serve the memory and significance of Alan Turing and celebrate our field. In the end, we decided to focus the ACM Turing Centenary Celebration on our most visible and relevant connection to Turing—the ACM Turing Award and its winners.


In this paper we provide empirical evidence of a strong relationship between the geographical approach of Diamond (1997) and the institutional approach of Acemoglu, Johnson et Robinson (2002) to explain gaps in economic performance worldwide since 11,000 BC until today. While the biogeographical endowments of Diamond are suitable to explain development paths until 1500 AD, the reversal of fortune of Acemoglu et al. (2002) is able to explain gaps in economic performance since 1500 AD. Those results display the positive impact of institutional framework on economic development, and focus on the complementary of two different fields of literature on long-run development.


This study aimed to investigate exercise self-efficacy, physical self-worth, and global self-esteem levels of athletes with physical disabilities. To examine the exercise and self-esteem model on athletes with disabilities, we explored the hierarchical relationship between self-efficacy, physical self-worth, and global self-esteem. Forty-one (N=41) basketball players who participated in the West Asian Championship answered the following three questionnaires: Exercise Self-Efficacy Scale, Physical Self-Description Questionnaire, and Rosenberg Self-Esteem Inventory. Descriptive statistics and the Pearson correlation coefficient were used for data analysis. Study participants achieved relatively high scores in all three variables: exercise self-efficacy (7.67±2.263), physical self-worth (4.41±.953), and global self-esteem (3.13±.516). As a significant correlation was found between exercise self-efficacy and physical self-worth but not between physical self-worth and global self-esteem, the exercise and self-esteem model concept was not supported in the present study.


I GOD II REALISM AND IDEALISM INTRODUCTION III BEING INTRODUCTION PART IV UNIVERSALS AND PARTICULARS INTRODUCTION PART V NECESSITY INTRODUCTION PART VI CAUSATION INTRODUCTION VII TIME AND SPACE INTRODUCTION PART VIII IDENTITY INTRODUCTION PART IX MIND AND BODY INTRODUCTION X FREEDOM AND DETERMINISM INTRODUCTION


The fluid conduction system is an important component part of the metallogenic research.Based on geological studies of the Jiaojia gold mine and trend surface analysis,the authors investigated the channel way and direction of ore fluid migration in this mine and,on such a basis,analyzed the style and driving force for fluid migration.It is held that the formation and spatial distribution of ore bodies were controlled by the fault fluid conduction system,and that the ore fluid moved on the whole from southwest upward and laterally.As the shatter degrees of rocks in the faulted structural zone were different in different positions,the porosities and rates of percolation were also different in different places,which affected the migration style of the fluid.The authors consider that the driving force of fluid migration was mainly caused by additional static water pressure resulting from structures,and that the upward intrusion of the anatectic magma accelerated the fluid migration.


Keynote Speech I.- Prediction = Power.- Next Generation Networks, IP and UMTS.- UMTS Terminal Testing: A Practical Perspective.- Testing of 3G 1xEV-DV Stack - A Case Study.- Testing SIP Call Flows Using XML Protocol Templates.- Towards Modeling and Testing of IP Routing Protocols.- TTCN-3.- An Intuitive TTCN-3 Data Presentation Format.- The UML 2.0 Testing Profile and Its Relation to TTCN-3.- Realizing Distributed TTCN-3 Test Systems with TCI.- TimedTTCN-3 Based Graphical Real-Time Test Specification.- Keynote Speech II.- Interoperabolity Events Complementing Conformance Testing Activities.- Automata-Based Methodology.- Testing Transition Systems with Input and Output Testers.- Generating Checking Sequences for a Distributed Test Architecture.- Conformance of Distributed Systems.- An Automata-Based Approach to Property Testing in Event Traces.- Fault Diagnosis in Extended Finite State Machines.- A Guided Method for Testing Timed Input Output Automata.- Interoperability Testing.- Interoperability Testing Based on a Fault Model for a System of Communicating FSMs.- Framework and Model for Automated Interoperability Test and Its Application to ROHC.- Keynote Speech III.- TestNet: Let's Test Together!.- Test Design, Tools and Methodology.- An Open Framework for Managed Regression Testing.- TUB-TCI An Architecture for Dynamic Deployment of Test Components.- Fast Testing of Critical Properties through Passive Testing.


To the Editor: In 2012, MacRae et al reported less frequent hematoma formation with buttonhole cannulation compared with standard needling. In a newly published long-term follow-up of that study, the authors observe a lack of benefit in survival of arteriovenous fistulas and a higher risk of infection with the buttonhole technique versus standard practice. As a result of a few other studies with similar results, buttonhole cannulation has fallen out of favor in the dialysis community. However, the follow-up study from MacRae et al raises important questions: Is the lack of survival benefit attributable to the increased risk of infectious complications? If infections can be prevented, will the fistulas last longer? A simple and relatively innocuous intervention with use of topical antimicrobial ointment prophylaxis has been demonstrated to reduce dramatically the risk of Staphylococcus aureus bacteremia in patients treated with nocturnal home hemodialysis. MacRae et al comment that topical mupirocin use was implemented toward the end of their study period, with no infections noted subsequently. Further longitudinal trials are needed to confirm this reduction in infectious risk and determine whether this translates into improved arteriovenous fistula survival. Moreover, refinements in the buttonhole technique itself (eg, use of polycarbonate pegs between treatments for creation of buttonhole tracks) were not evaluated in the MacRae et al study. These limitations highlight that it would be premature to abandon buttonhole cannulation, even for conventional hemodialysis patients. Ideal cannulation technique remains to be established. A cautious and individualized approach, with strict adherence to aseptic technique and updated protocols for creation of buttonhole tracks, is still warranted.


Multimedia technology is a very important direction in computer research area, the synchronizing control is a factor that must be considered in every multimedia system. Based on the question of multimedia's synchronizing control on WWW, the goal of SMIL formulated by W3C is analysed in examples, the research status of SMIL's implementation in the world is introduced, and the model of SMOD system which is defined by the authors is described. Finally, the important value of SMIL's development on WWW is summarized.


This chapter presents an approach to the scientific concepts on autism, diagnosis, and treatment criteria, as well as the assessment of knowledge on this subject and its relationship with the level of health literacy in the context of Angolan society. To substantiate the importance of health literacy, dimensions of access, understanding and use of health information, and decision making, an observational case study related to a research carried out in 2012 for the tracking of signs of autism is explored. The sample consisted of a group of 200 mothers of children and adolescents who were initially diagnosed with intellectual disabilities. This sample, for convenience, was selected from students who had previously been diagnosed with intellectual disabilities and attended a public school located in the municipality of Rangel, in the Province of Luanda, capital of Angola. The current stigma still exists about the disease.


Writing a history of early trigonometry brought me to confront in a practical way some difficult historiographic questions. What does it mean to know a theorem? How does one determine what belongs to trigonometry, and doesn't? To what extent can one legitimately talk about knowledge crossing cultural boundaries intact? Although these questions do not have clear answers, their introduction to a classroom setting could enrich and deepen students' perceptions of what mathematics is, and how culture interacts with it.


mapping during ablation, which could influence the ablation approach and often defines the prognosis of arrhythmia recurrence. Pathophysiological AF results in electrical and structural remodeling (inflammation, fibrosis, and atrial dilatation). LVA represent atrial remodeling processes and are considered to play an important role in AF progression.3 LVA can be found in 10% of patients with paroxysmal AF and in 35% of patients with persistent AF. However, by performing individually tailored substrate modification, a significantly higher arrhythmia-free survival rate compared with the conventional approach can be achieved.8 Furthermore, the reliable documentation of rhythm outcomes is not possible using 2 days' Holter monitoring, as the most of asymptomatic arrhythmia episodes, which occur frequently after ablation, cannot be adequately detected. Therefore, continuous ECG monitoring is preferred when analyzing the prediction of rhythm outcomes. Finally, the group with a very small LA was small compared with the other groups in this study, which could impair the statistical analysis and its interpretation. Furthermore, the patients in this group were young, had mostly paroxysmal AF (>90%) and low rates of cardiovascular comorbidities. All this does not really 'fit' with our understanding of AF progression and does not explain worse rhythm outcomes. In our opinion, this might be related to the poor access and manipulation during catheter ablation in a small atria. It would be interesting to see how single-shot devices such as the cryo-balloon would have performed in this patient group. Although not explicitly mentioned in the manuscript, probably a double-transseptal approach was used with simultaneous LA access by 2 long sheaths; this could in particular affect the results because in very small atria this technique is rather demanding in terms of manual skills. In summary, the role of LA size remains an interesting topic with regard to predicting LVA and rhythm outcomes. However, because AF is a multifaceted disorder including polymorphic mechanisms during its development and perpetuation, a meaningful combination of different variables (imaging, biomarkers, patients' clinical profile) could be helpful in shaping individualized AF management and predicting rhythm outcomes.


The invention relates to an oil well cement coagulation-accelerating early strength agent and a preparation method thereof, and belongs to the technical field of oil well cement additives. The early strength agent is prepared from, by weight, 10-50 parts of gypsum powder, 10-40 parts of quick lime and 10-50 parts of aluminum salt. The purposes that the agent is quite convenient to use, and the synergistic interaction of organic salt and inorganic salt is sufficiently utilized can be achieved, and cement paste can rapidly set at low temperature.


In order to investigate the relationship between operation and biological community,different operational periods of biological phosphorus removal (BPR) including setup period,stable period and deteriorative period were analyzed in an anaerobic/aerobic sequencing batch reactor (SBR). PCR-DGGE protocol was employed for revealing succession of microbial community structure and changes of functional bacteria related to BPR in different periods. The setup period lasted 26 days,including lag phase and rising phase. During these two phases,phosphorus removal efficiency enhanced from less than 40% to 80%. After that,stable period started represented by stable phosphorus removal efficiency of more than 80%. Tetrasphaera elongate,Gemmatimonas aurantiaca and Uncultured γ-proteobacterium were dominant as functional microbes in stable period. Stable period lasted 80 days,and then the BPR went into deteriorative period with a phosphorus removal efficiency of less than 70%. Microbial community structure of stable period and deteriorative period varied greatly. Uncultured γ-proteobacterium,which acted as potential polyphosphate accumulating organisms (PAOs),was eliminated from the reactor while the major competitor Candidatus Competibacter phosphatis clone SBRQ22 increased significantly leading to deterioration of BPR system.


ANIMAL EXTRACTS. -SOME preliminary observations with the arteriometer having afforded me evidence that certain of the animal extracts (such as those of the suprarenal bodies, the thyroid gland, and the brain tissue), when administered to healthy subjects by the mouth modify tile calibre of the arteries, I was led to avail myself of the resources of the laboratory in order to determine the matter. In this investigation I had the invaluable co-operation of Professor Schafer.i The extracts employed were those derived from the suprarenal bodies, the thyroid gland, the spleen, and the pituitary body. They were prepared for the most part with water (in the earlier part of the inquiry with glycerine) and either from the fresh glands, or from glands dried rapidly at 380 C. The suprarenal extract is the only one of the series which has been in-, vestigated in any detail; but as the effects on the blood pressurehiave been determined in a preliminary way in the others, I will refer to them before describing more particularly the physiological action of the suprarenal extract. Intravenous injection of tlhyroid extract produced a marked fall in the blood pressure, although the beats of the heart remained the same i.n frequency and strength. Therefore it may be inferred that the lowering of the blood pressure was the direct result of increase in the calibre of the arteries--an inference which derives support from the observation which had previously been made with the arteriometer. This direct action on the vascular system may be connected with important functions, such, for instance, as the heat regulating function. The subjects of myxcedema and animals on which thyroidectomy has been performed are particularly prone to suffer from subnormal temperatures. Lorrain Smith has demonstrated that thlyroidectomised animals react to change -of temperature with abnormal rapidity, as indicated bythe shortening of the time required for the augmented emission of carbonic acid which follows exposure to a low temperature.2 It is, therefore, not unlikely that in myxcedema the witlhdrawal of the internal secretion of the thyroid, which acts directly in dilating the vascular system, may in a measure account for the reduction of the temperature so frequently observed and for the development of other signs of lowered vitality. We are not, however, prepared to assert that this effect of thyroid extract on the arterial wall is specifie; for, ; we have found that a similar result is obtained by the intra-venous injection of decoctions of some other glandular organs, for example, the parotid and submaxillary glands of the dog. The intravenous injection of spleen extract produces a somewhat characteristic curve of blood pressure, consisting of a preliminary fall succeeded by a gradual rise and by as gradual areturn to the normal. The significance of this curve has not been as yet investigated. On the other hand, the pituitary and suprarenal extracts were found to possess the ..property of exciting powerful contraction of the arteries, and of raising the blood pressure to a very marked degree. The action ofboth these extracts on the vascular system is not only different in character from that of the thyroid and spleen extracts, but is more energetic. Moreover, though they possess the common property of constricting the arteries, they themselves present certain points which differentiate the one from the other, such as the following: I. The pituitary extract, though the effect of it is well marked, is less active than the suprarenal; for a much larger dose of it is required to produce the same rise of blood pressure. 2. The pituitary curve of blood pressure rises more slowly, and is maintained for a longer time than the suprarenal curve; the active principle is, therefore, less readily eliminated from the blood than that of the suprarenal.


A novel 3D MOF based on dysprosium(iii) oxalate and 1,10-phenanthroline (phen), {[Dy(C2O4)1.5phen]·0.5H2O}n (1), has been hydrothermally synthesized. The Dy(3+) ion acts as a typical Y-shaped node, linking to each other to generate an interesting 3D topology structure. Complex 1 is the first 3D DyMOF displaying both ferromagnetic coupling and field-induced two-step magnetic relaxation.


Background: Cardiomyopathy (CM) is a cardiac muscle disorder that can lead to heart failure (HF). It has several phenotypes, including dilated, hypertrophic, and restricted. Pro-inflammatory cytokines play a crucial part in the development and advancement of CM. Objective: This study aimed to measure the concentration of certain cytokines [Interleukin- 1β (IL-1β), Interleukin-6 (IL-6), and Tumor Necrosis Factor (TNF-α)] in the serum of Iraqi patients with CM. Materials and Methods: Sixty CM patients and 30 healthy individuals with age ranged from 40 to 70 years old were enrolled in this study through their presence at Iraqi Center for Heart Diseases, Ghazy Al-Hariri Hospital for Surgical Specialties in the Medical City in Baghdad. The study was conducted from November 2021 to April 2022. Blood samples were collected to evaluate the level of Interleukin IL-1β, IL-6, and TNF- α using ELISA technique. Results: The findings revealed a highly significant (P≤0.01) increase in the level of IL-1β IL-6 and TNF- α (15.71 ±0.33 pg/ml, 65.84 ±0.73pg/ml, and 17.81 ±0.58 pg/mL) respectively in comparison with control (4.59 ±0.17 pg/ml, 7.60 ±0.18pg/ml, and 6.26 ±0.34 pg/mL) respectively. Conclusion: It can be concluded from the current results that the pro-inflammatory cytokines play a major role in the development and severity of cardiomyopathy in Iraqi patients.


In 1996 and 1997, a rescue excavation was mounted at a previously unregistered cemetery site locally known as Khirbet Qazone, near the village of Mazra'a at the southeastern end of the Dead Sea (figs. 10.1 and 10.2). Over 3,500 looted burials were recorded but of these, only twenty-three undisturbed shaft graves were excavated by archaeologists.1 Each of these graves had a single burial and there was no evidence of re-internment. Most of the graves were dug more than 1.5 m into the soft Lisan sediments, undercut to the east, and covered by adobe brick slabs in what can best be described as arcosolia (fig. 10.3). At least two graves were constructed of stone cists. Men, women, and children alike were laid to rest on their backs with their heads placed towards the south end of the grave. CHAPTER TEN


Background:There are limited data from high-income countries on the performance of interferon-gamma release assays in screening for latent tuberculosis infection (LTBI). We analyzed the routine application of the Quantiferon-TB Gold (QFT-G) assay to detect and predict latent and active TB among HIV-infected patients in Australia. Methods:A retrospective cohort study included all HIV-infected patients attending the Melbourne Sexual Health Service between March 2003 and February 2011 who were screened for LTBI using QFT-G. Clinical data were analyzed in multivariable models to determine predictors for QFT-G positivity using logistic regression and active TB development using Cox proportional hazards. Results:Nine hundred seventeen HIV-infected patients had ≥1 QFT-G performed, of whom 884 (96.4%) were negative, 29 (3.2%) positive, and 4 (0.4%) indeterminate. The mean age was 40.9 years and 88% were male, with median follow-up of 26.4 (interquartile range 15.4–30.7) months. Five hundred fifty (63%) were Australian born, whereas 198 (23%) were born in Asia or Africa. QFT-G was positive in 2.0% of Australian-born, 5.3% of overseas-born [odds ratio: 2.6, 95% confidence interval (CI): 1.2 to 5.6, P = 0.017], and 12.7% of African-born patients (odds ratio 7.1, 95% CI: 2.9 to 17.3, P < 0.001). Two cases of culture-positive TB occurred after QFT-G screening in 3.4% of QFT-G–positive and 0.1% of QFT-G–negative patients (adjusted hazard ratio: 42.4, 95% CI: 2.2 to 827, P = 0.013), a rate of 111 (95% CI: 27.8 to 445) per 100,000 person-years. Conclusions:In this context, QFT-G has a high negative predictive (99.9%) value with few indeterminate results. A risk stratification approach to LTBI screening, where HIV-infected patients with epidemiological risk factors for TB infection undergo QFT-G testing, might be clinically appropriate and potentially cost effective in similar settings.


Do ergonomics have more functions than preventing injuries? This study examines how four guitarists can benefit from playing with ergonomics in focus. The study examines how it helps their endurance, technique, focus and relaxation while playing guitar. The guitarists have been given instructions on how to practice more ergonomically. The study is designed as action research in which the guitarists have been videotaping themselves when they practice, followed by writing a diary after their practice sessions. The videos and diaries have been the foundation of my result. The result shows that the informants feel more relaxed and their playing feels easier with an ergonomic workflow. It also shows an increased level of consciousness and how they can reflect by themselves and improve their ergonomics. The informants noticed that is was difficult to maintain the ergonomic workflow when they improvised. Easy exercises in improvisation was necessary in the beginning to integrate the ergonomics. (Less)


It is well known to readers of this journal that the British labor movement is in a state of precipitous decline. A recent government White Paper, for example, reports that since 1990 alone the percentage of workplaces with no union members at all has risen from 36 percent to 47 percent. Perhaps more ominously, the percentage of workplaces that recognize trade unions has dropped from 66 percent in 1984 to 45 percent in 1998. From 1979, when trade union density was estimated at over 55 percent of the workforce, it is now hovering somewhere between 30 and 35 percent. It is safe to say that this low level has not been seen in Britain since before World War Two. Chris Wrigley's contribution to Manchester University Press's fine series on contemporary British history offers a timely collection of documents on the origin and development of these events. By design, this collection focuses on documents generated by the government, political parties, and private interest groups, most notably the Trades Union Congress (TUC). Thus six of the book's nine chapters provide a chronological overview of the vagaries of the British government's industrial relations policies during the postwar era, adequately supplemented with extracts from official TUC responses. Wrigley himself provides an effective and thoughtful editorial introduction that emphasizes not only just how precarious the trade unions' former position actually was, but also just how deep resentments against unions ran among certain sections of the Conservative party.


The oxygen element is harmful to Si steel, and the RH refining deoxidation method has an important effects on oxygen concentration. Based on the industrial non-oriented Si steel containing Al, the effects of RH refining deoxidation method on non-metallic inclusions were discussed. Results show that the deoxidation rate of the Si-Al deoxidation method is higher than that of the Al-Si deoxidation method. For the Al-Si deoxidation method, the oxygen concentration of liquid steel is sharply decreased. In order to decrease the variation of oxygen concentration for Si-Al and Al-Si deoxidation method, it is necessary to get an optimal Si content and degassing time. In addition, for Si-Al deoxidation method, the main non-metallic inclusion containing Si O2 accounts for the total of 86.7%. For Al-Si deoxidation method, the main non-metallic inclusion containing Al2O3 accounts for the total of 84.6%. Thus, the effects of Si-Al deoxidation method are better than that of the Al-Si deoxidation method, and the proportional of minus non-metallic inclusions in slab is also less than that of the Al-Si deoxidation method. This is beneficial to i mprove the magnetic properties of the finished Si steel sheets.


Fuel cells are being developed to replace batteries in portable electronic devices and internal combustion engines in automobiles. Key challenges to the commercialization of protonexchange membrane (PEM) fuel cells include high cost and poor durability. One of the primary cost-drivers is the membrane electrode assembly (MEA), which consists of the catalysts, electrolyte membrane, and gas diffusion layers (GDLs). Improving PEM fuel-cell cost and performance will require more efficient utilization of the catalyst and a reduction in the thickness of the MEA membrane, which requires optimization of the nano- and sub-micron structure of the membranes. [1–11] Recently layer-by-layer assembly (LBL) [12] has been used to prepare substructures for PEM fuel cells [13–18] as a tool for balancing different conflicting requirements. LBL makes possible simple incorporation of conductive nanocomponents, conformal coatings of surfaces of any complex geometry, high ionic contents of the multilayers, nanometer-scale control over film thickness, and film porosity. These features make LBL an attractive new technology for fuel-cell assembly. Liu and co-workers reported the fabrication of an electrode-incorporating catalyst in MEA via the reduction of a Pt precursor on the surface of a Nafion membrane, [13] and Farhat and Hammond used LBL-made membranes as a separator of cathode and anode and reached power densities with conventional carbon black (CB) electrodes of 16.5 mWcm –2 . [18] The LBL assembly of ligand-stabilized platinum nanoparticles was also used to build three-dimensional nanostructured electrodes with a mass-specific activity of 0.11 Amg –1 Pt at 0.9 V for a 5 layer film. [14] Unfortunately, these films were not tested in an actual fuel cell and 5 layer films are somewhat questionable as a functional part of MEA. LBL thin films deposited as a barrier layer on a Nafion membrane were also suggested to be effective for the reduction of methanol cross over for direct methanol fuel cells. [15] LBL multilayers of polyaniline (PANI)/poly(acrylic acid)-co-polyacrylamide (PAA-co-PAAm) film doped with Pt by reductive precipitation of a Pt salt (H2PtCl6) yielded a maximum Pt loading of 0.3 mgcm –2 . [18] Using a somewhat different approach for particle incorporation, carbon-polymer electrodes were constructed using polyelectrolytes and commercially available colloidal dispersions. [18] The electrodes exhibited electronic conductivities of 2–4 Scm –1 and ionic conductivities in the range from 10 to 10 –3 Scm –1 . Overall, despite the many favorable characteristics of the technique, the performance of the produced PEM and other fuel cells was substantially below the traditional ones with CB, and this can be attributed to suboptimal organization, such as an islandlike distribution of Pt particles [13] and fairly low conductivities. In this paper we report the use of carbon-nanotube and


Central venous stenosis (CVS) is a common but underestimated complication of vascular access in hemodialysis (HD) patients. The objective of this study was to compare the diagnostic efficacy of echocardiography and computed tomography angiography (CTA) for CVS in HD patients with access dysfunction.

 This was a retrospective study. HD patients with access dysfunction admitted to our institute between 1 April 2021 and 31 October 2021 were enrolled. Echocardiography, CTA and digital subtraction angiography (DSA) were performed to assess CVS. Receiver operator characteristic analysis was performed to compare the diagnostic efficacy of echocardiographic parameters and CTA for CVS, with DSA results as the reference standard.

 A total of 167 HD patients (70 males, age 63 ± 13 years) were enrolled, among whom 99 (59%) were diagnosed with CVS based on DSA and only 9 presented with significant clinical symptoms of CVS. Among all of the echocardiographic parameters, superior vena cava (SVC) diameter showed the highest efficacy for CVS diagnosis (cut-off value ≤12 mm, specificity 70%, sensitivity 77%), which was equivalent to CTA (AUC 0.79 versus 0.81; P = 0.646) (Figure 1A). Some of the other echocardiographic parameters, including maximal and minimal right atrial volume (RAV), also showed moderated diagnostic efficacy for CVS. The specificity and sensitivity increased when echocardiography and CTA were used to diagnose brachiocephalic vein and SVC stenosis instead of total CVS (Figure 1B). Patients with CVS had a smaller SVC diameter (9.8 ± 3.5 mm versus 13.7 ± 3.3 mm;  P < 0.001) and a reduced right RAV [RAV max median 20 (interquartile range 15–27) mL versus 31(24–39) mL; P < 0.001; RAV min 8 (5–10) mL versus 14 (10–17) mL; P < 0.001] compared with non-CVS patients. Spearman's rank correlation showed a significant negative correlation between RAV and hemodialysis vintage.

 With equivalent diagnostic power for CVS to CTA, echocardiography has the potential to be used as a screening and monitoring tool for CVS in HD patients with access dysfunction.


This paper discusses the synthesis and performance of a family of medium (5 to 8%) fractional bandwidth SPUDT filters for a miniature UHF SAW channelizer. These filters employ chirped input and output transducers to overcome the otherwise limited electrode reflectivity needed for the required fractional bandwidth. They are designed to achieve moderate insertion loss, low time-domain spurious, and high out-of-band rejection without the need of electrical matching. A modified electrode-width controlled (EWC) scheme is devised to implement the desired transduction and reflection weightings


Presented was the experience of the Department of Pediatrics and Perinatology in teaching, Neonatologyand the main scientific and practical activities for the period from 1990 to 2010.


STATIC TESTS ARE DESCRIBED OF SIX HYBRID PLATE GIRDERS COMPRISED OF A514 STEEL FLANGES AND A36 STEEL WEB. FIVE SPECIMENS WERE TESTED UNDER PURE BENDING AND ONE UNDER HIGH SHEAR. THE BENDING TESTS WERE CONDUCTED TO PROVIDE INFORMATION ON THE BUCKLING BEHAVIOR OF THE COMPRESSION FLANGE AS IT IS AFFECTED BY THE YIELDING IN THE WEB AND TO DETERMINE EXPERIMENTALLY THE ULTIMATE LOADS AND TO COMPARE THEM WITH REFERENCE VALUES COMPUTED ON THE BASIS OF ELASTIC AND PLASTIC BEAM THEORY. THE SHEAR TESTS WERE CONDUCTED TO INVESTIGATE HOW WELL THE CURRENT ULTIMATE SHEAR-STRENGTH THEORY PREDICTS THE ACTUAL STRENGTH DETERMINED BY TESTS. WEB SLENDERNESS RATIOS AND FLANGE WIDTH-TO-THICKNESS RATIOS WERE VARIABLES CONSIDERED IN THE BENDING TESTS. FOR THE SHEAR TESTS, ONLY THE TRANSVERSE STIFFENER SPACING WAS VARIED. THE BEHAVIOR OF EACH GIRDER IS DESCRIBED AND RESULTS PRESENTED. IN ALL GIRDERS, THE ULTIMATE LOAD EXCEEDED THE WEB YIELD LOAD BY A SUBSTANTIAL MARGIN, DEPENDING PRIMARILY ON THE B/T RATIO OF THE COMPRESSION FLANGE. IT WAS DETERMINED THAT TENSION-FIELD THEORY COULD BE USED TO PREDICT THE ULTIMATE LOAD FOR HYBRID GIRDERS SUBJECTED TO HIGH SHEAR. /AUTHOR/


If a signal is known to have a sparse representation with respect to a given frame, the signal can be estimated from a noise-corrupted observation of the signal by finding the best sparse approximation to the observation. The ability to remove noise in this manner depends on the frame being designed to efficiently represent the signal while it inefficiently represents the noise. This paper gives bounds to show how inefficiently white Gaussian noise is represented by sparse linear combinations of frame vectors. Combined with knowledge of the approximation efficiency of a given family of frames for a given signal class, this work leads to a better understanding of the merits of frame denoising.


To the Editor: —According to Dublin and Spiegelman (1948), and March (1950), leukemia causes death 8 to 9 times oftener in radiologists than in all other physicians. It is also a more frequent cause of death in dermatologists. To determine whether physicians are an example of the rule of inverse association under additional exposure (Peller), second, whether and to what extent fluoroscopy endangers the general practitioner and internist, and, third, how soon the danger of leukemia becomes manifest, we surveyed the necrologies published inThe Journalfrom June 1, 1947, to June 1, 1951. The cause of death is listed for 9,354 physicians (no cause is given in 2,568). Among them are 111 deaths from leukemia and 1,134 from other malignant diseases. The ratio of all deaths from malignant diseases to all deaths (with given cause) is thus 13.2% as compared with 14% for all white males who in 1947


Abstract The problem of the active fault tolerant control (FTC) with reconfiguration mechanism for linear systems with external disturbances is addressed with application of the supervisory control approach. Starting from the well known in FTC literature conditions for independent design of fault detection, isolation and fault compensation systems we propose new set of united conditions and the computational procedure providing mutual performance of the system. The efficiency of the approach is demonstrated on a flight system benchmark example.


A highly innovative miniature silicon comb to sense differential microphone diaphragm has been developed that is highly stable when subjected to various bias voltages [1]. The bio-inspired microphone diaphragm consists of a 1 mm by 2 mm stiffener-reinforced plate fabricated out of phosphorous-doped polysilicon that is supported on a central hinge [2,3,4]. Interdigitated comb fingers are formed around the perimeter at the ends of the diaphragm by reactive ion etching the polysilicon to create the gaps between the two sets of comb fingers. A fabricated prototype device has demonstrated that this design avoids many key limitations of capacitive microphones through use of a unique comb-sensing design and approach. It provides the means for design and construction of highly innovative capacitive microphones with enhanced sensitivity that can be readily and cost-effectively produced via silicon microfabrication techniques [5].


Summary.  The impact of ribavirin exposure on virologic relapse remains controversial in combination therapy with pegylated interferon (Peg‐IFN) and ribavirin for patients with chronic hepatitis C (CH‐C) genotype 1. The present study was conducted to investigate this. Nine hundred and eighty‐four patients with CH‐C genotype 1 were enrolled. The drug exposure of each medication was calculated by averaging the dose actually taken. For the 472 patients who were HCV RNA negative at week 24 and week 48, multivariate logistic regression analysis showed that the degree of fibrosis (P = 0.002), the timing of HCV RNA negativiation (P < 0.001) and the mean doses of ribavirin (P < 0.001) were significantly associated with relapse, but those of Peg‐IFN were not. Stepwise reduction of the ribavirin dose was associated with a stepwise increase in relapse rate from 11% to 60%. For patients with complete early virologic response (c‐EVR) defined as HCV RNA negativity at week 12, only 4% relapse was found in patients given ≥12 mg/kg/day of ribavirin and ribavirin exposure affected the relapse even after treatment week 12, while Peg‐IFN could be reduced to 0.6 μg/kg/week after week 12 without the increase of relapse rate. Ribavirin showed dose‐dependent correlation with the relapse. Maintaining as high a ribavirin dose as possible (≥12 mg/kg/day) during the full treatment period can lead to suppression of the relapse in HCV genotype 1 patients responding to Peg‐IFN alpha‐2b plus ribavirin, especially in c‐EVR patients.


The acid dissolution of 8 chlorites in 2N Si-saturated HCI showed that there was no preferential dissolution of Al in octahedral positions and that the octahedral and tetrahedral sheets in the chlorite structure were equally attacked. An analysis of chemical data suggested a simple twodimensional diffusion model in which the acid attack on the chlorite particles proceeded from the edges inward leaving a reacted layer which formed a diffusion barrier. Microscopic examination showed, however, that the acid attack was not simply an edge attack but started at any point where cracks, structural defects and weaknesses apparently predisposed sites to acid attack. It was also clear from the formation of etch figures and solution channels that the product layer at least partially dissolved or disintegrated during the progress of acid attack. The residue which remained after acid attack appeared to be an opaline amorphous hydrated silica as was indicated by index of refraction measurements. The orderly arrangement of etch figures on flakes of some chlorites reflected certain crystal symmetry elements. The results indicate that the acid dissolution technique to determine the ratio of Al in octahedral and tetrahedral positions can not be used as an aid in the calculation of structural formulae for chlorites. INTRODUCTION IN STUDIES on the stability of chlorites in acid solutions (Brydon and Ross, 1966; Ross, 1967; Ross, 1968), it was found that a clinochlore from New York reacting with 2N HCl released Mg, Fe and Al at equal rates. According to the chemical data the reaction appeared to be diffusion controlled (Ross, 1967) but this was not confirmed by the combined data from X-ray and thermal analyses of the residues (Ross, 1968). These results were rather unexpected because one of the first studies on the acid dissolution of an orthochlorite by Brindley and Youell (1951) showed that the Al in octahedral positions dissolved at a faster rate than the Al in tetrahedral positions in the chlorite structure. Since then results of several acid dissolution studies on different phyllosilicates have been interpreted as indicating a faster dissolution rate of octahedral than oftetrahedral AI, (Cloos et al., 1961 ; Gastuche et al., 1960; Gastuche and Fripiat, 1962; Osthaus, 1954; Osthaus, 1956). Because these results suggested that octahedral and tetrahedral Al could be distinguished chemically by this method, the acid dissolution technique has been used as a tool to determine directly the ratio of octahedral to tetrahedral Al in the structure of phyllosilicates. In some acid dissolution studies the dissolution *Contribution No. 308. rates were designated pseudo-first order (Cloos et al., 1961; Miller, 1965; Osthaus, 1954; Osthaus, 1956) or pseudo zero order (Miller, 1965, 1968). In other studies the influence of particle shape on reaction rate was considered and the data appeared to fit a phase-boundary controlled reaction (Chaussidon and Valain, 1962; Gastuche et al., 1960; Gastuche and Fripiat, 1962). The purpose of this study was to (1) investigate whether different chlorites would dissolve in a similar manner as the clinochlore from New York or whether this clinochlore would be an exception in the dissolution behavior of chlorites, (2) compare the stability of different orthochlorites in acid, (3) examine the progress of acid attack on chlorite flakes under the microscope in an attempt to clarify the reaction mechanism. EXPERIMENTAL The acid dissolution of eight chlorites was studied. Their chemical analyses are given in Table l, as determined by X-ray spectrochemical analysis (Kodama et al., 1967) except FeO which was determined by the method of Reichen and Fahey (1962). The required particle size fractions were obtained by filing the original rocks and passing the particles obtained through the appropriate sieves. The purity of the chlorites was checked by X-ray diffraction which indicated that chlorite


A uniform shear stress field was generated by using a co-axial cylinder apparatus to study the short-period effects of shear stress (t = 0.16, 0.46, 0.78Pa) on the Taxus cells physiology. Results showed that the cells grew well and the primary metabolism was vigorous when 0.16Pat 0.46Pa, and that the cells had the tendency to accumulate more secondary metabolites when 0.46Pat 0.78Pa. Meanwhile, a 3-D CFD simulation of the hydrodynamics characteristics in a 20L impeller stirred bioreactor (45-upward Pitched-Blade-Turbine, (1/3) T of the off-bottom clearance) was conducted to obtain the shear stress field inside the reactor. It could be seen that the strength of the shear stress was inhomogeneous and mainly concentrated in the impeller swept and wake flow regions, which was more than 7 times higher than that in the bulk and baffle regions. By combining the experimental results and CFD simulations, the effects of the shear stress on Taxus cells cultured in impeller-stirred reactors were predicted. Results showed that the impeller agitating speed less than 150 rmin-1 is beneficial to cell growth and primary metabolism. Whereas when the agitating speed is higher than 200 rmin-1, the magnitude of the average shear stress in the reactor will be too big and become unsuitable to cell culture.


Zooxanthellae are phototrophic dinoflagellates that occur as endosymbionts in many marine invertebrates. Because traditional biological methods have not provided useful schemes for zooxanthella identification and classification, the natural history of zooxanthella symbioses is poorly known. We have apphed molecular genehc methods to zooxanthella taxonomy. Small ribosomal subunit RNA (ssRNA) genes can be rapidly obtained from small amounts of symbiotic (non-cultured) algae by gene amplification using the polymerase chain reaction. Different Symbiodinium-like zooxanthellae are then identified by digesting the amplified DNA with restriction enzymes. A sample of 16 cnidarian host species yielded 6 distinct Symbiodinium ssRNA genes: different Hawaiian corals harbored dfferent algae, but different individuals of the same coral species harbored indistinguishable algae. The corals Pocillopora damicornis and P. meandrina appear to contain a mixture of 2 zooxanthella ssRNA genes; other hosts exhibited a single zooxanthella genotype. The same algal genotype occurs in taxonomically dissimilar hosts.


Dr Purdy may fairly claim to have attained the object for which this book was written?namely, " to furnish the physician and student with the present status of our knowledge on the subject of diabetes in such practical and concise form as shall best meet the daily requirements of practice." The matter is put briefly but comprehensively, and the book will doubtless be of value to those who desire the maximum of information with the minimum of


Purpose

Young adult's drinking is about pleasure, a communal practice of socialising together in a friendship group. The purpose of this paper is to investigate the evolving support practices of drinking groups for better targeting of health communications messages.

Design/methodology/approach

This qualitative descriptive study examined the narratives of 28 young people's (age 18-24 years old) experience of a "night out" framed as the Alcohol Consumption Journey.

Findings

The Alcohol Consumption Journey ritual consisted of three phases: preloading, going out and recovery. The participants described multiple forms of support practices located at each phase of the Alcohol Consumption Journey for maximising pleasure, minimising risk, encouraging supportive behaviours, enhancing group cohesion and protecting the drinkers from alcohol-related harm. Hence, support practices played a critical part in constituting and consolidating the drinking group. While the support practices appeared to be structured into the Alcohol Consumption Journey, they were activated differently for young men and young women. Support practices were an important driver in perpetuating the Alcohol Consumption Journey.

Originality/value

The paper extends Vander Ven's concept of "drunk support" to better understand young adults' evolving support practices in the ritualised Alcohol Consumption Journey.


Clostridium difficile-associated diarrhea (CDAD) has been one of common nosocomial infections associated with previous antibiotic use. Early diagnosis and adequate management of CDAD is necessary especially for severe cases, however, diagnosis has not been satisfactory. Cytotoxicity assay or toxigenic culture can be considered as a golden standard for diagnosis of CDAD, however, they are labor intensive and require a long time. Instead, a rapid enzyme immunoassay for toxin A and B has been widely utilized in most clinical laboratories. However, its low sensitivity has also been a limitation. Sigmoidoscopy can be helpful in a rapid diagnosis of CDAD for some cases which show negative results in enzyme immunoassay.


A series of hydrotalcite-type solids with different compositions containing aminoacids (D,L-alanine and L-triptophan) between the cationic layers were prepared by the coprecipitation method at constant pH. In parallel twohydrotalcite samples containing (Ni and Al) and (Mg and Al) respectively, as reference samples, were prepared. The structure of the assynthesized solids was confirmed by X-Ray Diffraction and FTIR methods. The incorporation of the aminoacids during the synthesis in the interlayer anionic sheets was weighted by photocolorimetric analysis with ninhidrine. The lattice parameters values and the thermal behavior data show that the incorporation of the aminoacids in the hydrotalcite interlayers occured. The incorporation degree depends both on the aminoacid and the composition of solid.


The No. 2 generator of a thermal power plant is a 25MW extraction generator produced by Nanjing Turbomotor (Group) Co., LTD. The excitation regulator of this unit uses DVR-2000B digital excitation regulator provided by Nanjing Turbomotor (Group) Co., LTD. This report describes the parameter selection and field test results of the power system stabilizer (PSS) of the unit, and determines the operating parameters of the PSS according to the test results.


The invention discloses a novel taxane compound and a preparation method thereof. The taxane compound is prepared by the following steps of: (1) taking a compound 1 (10-deacetyl baccatin III (10-DAB) or an analogue thereof) as a starting raw material and reducing a 9-site carbonyl group into a 9 beta hydroxyl group in halogenated hydrocarbon, alkyleneoxide or mixed solvent of the hydrocarbon and the alkyleneoxide by using a boron-containing reducing agent to obtain a compound 2; and (2) standing the compound 2 in mixed solvent of alcohol, water and organic acid for a time to obtain a product 3, wherein the product 3 has the advantages of novel structure and unique activity, and the structure of the product 3 is corroborated by 1HNMR (1h Nuclear Magnetic Resonance) and X-single crystal diffraction tests. In-vitro pharmacological experiments show that the compound has activity of inhibiting tumor cell proliferation and promoting tumor cell apoptosis. In addition, the preparation method provided by the invention is simple, practical, low in production cost and suitable for wide popularization and application.


Background
 Allogeneic hematopoietic stem cell transplantation (alloHSCT) has been established as a powerful treatment modality for patients with hematological malignancies. The graft-versus-leukemia effect, however, is strongly associated with the occurrence of graft-versus-host disease (GVHD) and subsequent transplant-related mortality. The current standard Dutch regimen for prevention of GVHD in T-cell replete (TCR) alloHSCT following reduced intensity conditioning (RIC) consists of mycophenolic acid (MA) and cyclosporine A (CyA) for three and six months post-transplant, respectively. However, as approximately 30% of patients will never develop GVHD, immunosuppressive overtreatment is of concern and might impair outcome.
 Aims
 In the present prospective randomized, multicenter, phase III trial we set out to compare time-restricted immunosuppression versus a standard immunosuppressive regimen. The primary objective was to increase the proportion of patients with non-severe GVHD (either acute GVHD grades I-II without gut involvement or chronic GVHD not requiring systemic treatment) within 180 days after transplantation and to reduce the relapse rate, without increasing severe GVHD. Secondary endpoints included time to acute and chronic GVHD, progression-free survival (PFS), GVHD-free/relapse-free survival (GRFS), overall survival (OS), and adverse events.
 Methods
 Hematological patients planned to undergo TCR alloHSCT with a related or unrelated 8/8 HLA matched donor were included. The trial randomized patients between three treatment arms. The current analysis includes all patients randomized between arms A and B. Immunosuppression consisted of CyA twice daily aiming for serum trough levels of 250-350 µg/L and MA 16 mg/kg twice daily with a maximum dose of 2160 mg a day. The standard regimen (arm A) prescribed to discontinue MA at day 84 post-transplant and CyA was continued until day +120 followed by tapering until day +180. In those randomized for the time-restricted regimen (arm B) MA was discontinued at day 28 post-transplant and CyA was continued until day +84 followed by tapering.
 Results
 A total of 389 patients were randomized 1:1 between arms A and B, of whom 95% (184 in arm A versus 185 in arm B) proceeded to transplant. The median age was 55 (range: 18-71), 57% were male. Fifty-one patients received myeloablative conditioning and 318 (86%) patients RIC. Donors were matched siblings for 135 patients and matched unrelated donor (MUD) for 233 patients. The majority of patients received peripheral blood stem cells, consisting of median 6.46x106/kg CD34+ cells/kg (range: 0.94-26.3) and median 230x106/kg CD3+ T cells (range: 0-936). Baseline patient and transplantation characteristics were equally distributed between the treatment arms. The proportion of patients developing non-severe GVHD within 180 days post-alloHSCT was 24% in both treatment arms, with an odds ratio (OR) of 1.01 (95% confidence interval 0.61-1.67, p 0.98). The cumulative incidence (CI) of grade II-IV and grade III-IV acute GVHD at 6 months post-alloHSCT was not significantly different between the two arms (47% and 15% versus 52% and 18%), nor was the maximum grade or organ involvement of acute GVHD. In addition, no difference was seen in the two-year CI of chronic extensive GVHD between the two treatment arms (51% versus 49%). The three-year estimate of PFS was 51% (44-59%) versus 52% (44-59%), respectively. The three-year CI of progression/relapse was 28% in arm A versus 27% in arm B. OS at three years was 59% (0.51-0.66%) versus 57% (0.50-0.64%). The one-year estimate of the composite endpoint GRFS was 14% (9-19%) in arm A, and 17% (12-22%) in arm B. Incidences and nature of adverse events were comparable in both arms.
 Conclusion
 A time-restricted combination of MA and CyA did not increase the proportion of patients with non-severe GVHD within 180 days after transplantation and resulted in similar outcome as compared to standard immunosuppression following alloHSCT using sibling and well-matched unrelated donors. Given the observed high CI of acute grade II-IV and chronic extensive GVHD and low GRFS for both the time-restricted and standard regimen, recipients of TCR RIC alloHSCT should be considered for more intensive immunosuppression.
 Figure

 Nur: Novartis: Consultancy. Deeren:Alexion, Amgen, Janssen, Roche, Sunesis, Takeda, Sanofi: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding.


1. Forbes K, Westwood M, Baker PN and Aplin JD (2008) Insulin-like growth factor I and II regulate the life cycle of trophoblast in the developing human placenta. Am J Physiol Cell Physiol. 294 (6):C1313-22 2. Roberts CT, Owens JA, Sferruzzi-Perri AN.(2008) Distinct actions of insulin-like growth factors (IGFs) on placental development and fetal growth: lessons from miceand guinea pigs. Placenta Mar;29 Suppl A:S42-7. 3. Forbes K. (2013) Molecular control of placental growth: The emerging role of microRNAs. Placenta, 34(Supp), S27-S33. 4. Farrokhnia F, Westwood M, Aplin JD and Forbes K (2012) Identification of microRNAs involved in regulating growth factor signalling in the first trimester placenta. 6th International Conference of the GRS and IGF Society, Munich, Germany. Growth Hormone & IGF Research (2012) 22: S38 • miR-145 and IGF1R were quantified by RT-QPCR using specific primers and values were normalised to 5s and 18s rRNA, respectively.


Clinical simulation models have long been employed to teach clinical skills. The usage promotes satisfaction and confidence in learning among nursing students to learn the clinical skills. The study aimed to investigate the undergraduate nursing students' satisfaction and self-confidence in learning using the clinical simulation models. It also determined the relationship between student satisfaction with self-confidence in learning. This quantitative cross-sectional survey employed Student Satisfaction and Self-Confidence in Learning Scale from the National League for Nursing. The 118 samples were recruited using the stratified sampling method among all years of undergraduate nursing students in a Public University in Malaysia. Descriptive statistics was used to describe the samples and scores of Student Satisfaction and Self-Confidence in Learning. Spearmen correlation was employed to test the relationship between Student Satisfaction with Self-Confidence in Learning and significant level was determined at p less than.05. Hundred and eighteen respondents with the age ranged from 20 to 25 years (M = 21.73, SD = 1.19) were females (91%) and nine (8%) were males. The overall satisfaction was more than 3.5 (M = 3.89, SD = 0.54). The overall self-confidence was also high (M = 4.01, SD = 0.68). The Spearman correlation result showed that the two variables were weakly correlated, r (116) = 0.485, p =.000. The findings showed that undergraduate nursing student in this study conveyed a high satisfaction and self-confidence in learning using the clinical simulation models despite a weak correlation between the two variables (p <.05). It is crucial that the simulations be continuously used with the hope of improving their clinical practice. The result of this study is relevant in supporting the used of simulation models in nursing education. It is recommended that future studies to include qualitative method to provide rich data on nursing student's experiences.


The purpose of this paper is to present an analysis of the reception of classical poetic metre in Renaissance music.


The structural characteristics of autoreactive-T cell receptor (TCR) engagement of major histocompatability (MHC) class II-restricted self-antigens is established, but how autoimmune-TCRs interact with self-MHC class I has been unclear. We examined how CD8 + T cells kill human islet β-cells, in Type-1 diabetes, via autoreactive-TCR (1E6) recognition of an HLA-A*0201-restricted glucose-sensitive preproinsulin peptide. Rigid 'lock-and-key' binding underpinned the 1E6-HLA-A*0201-peptide interaction, whereby 1E6 docked similarly to most MHCI-restricted TCRs. However, this interaction was extraordinarily weak, due to limited contacts with MHCI. TCR binding was highly peptide-centric, dominated by two CDR3-loop-encoded residues, acting as an 'aromatic-cap', over the peptide MHCI (pMHCI). Thus, highly focused peptide-centric interactions associated with suboptimal TCR-pMHCI binding affinities might lead to thymic escape and potential CD8 + T cell-mediated autoreactivity. led the investigation and conceived the project. performed crystallization and surface plasmon resonance studies. The major histocompatibility complex (MHC) on human chromosome 6 is the most important genetic locus for human autoimmune diseases, indicating that T cell recognition of self antigens initiates and drives pathology 1, 2. Most, but evidently not all, self-reactive T cells are eliminated in the thymus by negative selection 3. Hence, there is a pressing need to better understand the molecular interactions through which disease-relevant T cell receptors (TCRs) bind to self-derived peptide-MHC (pMHC) ligands and escape thymic negative selection to populate the periphery. Structural studies of numerous non-autoimmune TCR-pMHC complexes have demonstrated that this can be a variable and versatile interaction 4-14 in which a prototypic diagonal TCR-pMHC docking mode is utilized with the variable (V)α and Vβ domains of the TCR positioned over the α2-and α1-helices of the MHC molecule, respectively 4, 15. In contrast, the current structural database for human autoantigen-reactive TCRs in complex with their self-ligands is highly limited. Three complexes exhibit atypical binding properties when compared to pathogen-specific TCR-pMHC complexes 13, 16, 17 , such as a predominant focus on the N-terminal region of the peptide or excessive tilting 13, 16 , leading to the notion that autoreactive TCRs have an abnormal docking mode. However, only four structures in total have been described to date and all are MHCII-restricted and specific for myelin basic protein (MBP) 13, 14, 16, 17 , an autoantigen targeted in multiple sclerosis. At present, no structural or molecular data exist for other human autoimmune diseases. More importantly, there has been no exploration of the molecular interaction between an autoreactive TCR and pMHCI displayed on …


Electricity market regulations are evolving to foster the integration of renewable energy sources in power systems and induce a cost-efficient transition towards a decarbonized system. Energy storage systems play a key role in this process and investing in such technologies is becoming an increasingly interesting option for stakeholders in the energy sector. This paper focuses on the Italian electricity market and assesses the benefits of energy storage in a realistic operation scenario. The results of a cost/benefit analysis for the enhancement of a real 80 MVA wind farm with an energy storage system are presented. The real grid services costs obtained for different locations of the Italian electricity markets have been processed, and proper bidding strategies aimed at simulating the market settlement have been defined, demonstrating the complexity of the decision process and the main variables affecting its outcomes.


In this dynamic world, women entrepreneurs are significant for the economic development of a country in general and development of women in particular. Now a days a number of women are seeking professional education to enter into an independent business/professional activities. They have entered in independent business/professional activities such as manufacturing, trading and a number of professional activities such as doctors, archictects, lawers, beauticians etc. The present empirical study has been carried out in Aurangabad city of Marathwada region in Maharashtra, India. In the sphere of entrepreneurial development, women are constrained by a variety of socio-economic factors. Therefore it is important to understand conducive and inhibiting factors to the development of women entrepreneurship. The present study was conducted to understand the factors, conducive as well as inhibiting, to the development of women entrepreneurship in Aurangabad , one of the cities of Maharashtra State in India. Key Words: Economic Growth, Conducive Factor, Inhibiting factor, Entrepreneurship.


Introduction: literary remains: the body as matter for text 1. Dull organs: the matter of the body in the plague year 2. The burthen in the belly 3. Consuming desires: Defoe's sexual systems 4. Flesh and blood: Swift's sexual strategies 5. The ladies: d--ned, insolent, proud, unmannerly sluts 6. Chains of consumption: the bodies of the poor 7. Consumptive fictions: cannibalism in Defoe and Swift Afterword: ... suppose me dead and then suppose ... Notes.