Infectious disease specialists have long warned that environmental damage and climate change will increase the risk of "zoonotic spillovers" or the spread of viruses from animals to humans. We have experienced the emergence and re-emergence of several viruses during the COVID-19 pandemic like Monkeypox (MPX) and Marburg virus posing threat to human health. In August 2022, a new zoonotic disease, Langya virus (LayV) identified in Shandong and Henan province of Eastern China emerged.1 Langya virus belongs to the family Paramyxoviridae under the genus Henipavirus and is closely related to two fatal zoonotic henipaviruses known to infect humans: Hendra virus (HeV) and Nipah virus (NiV) that cause severe respiratory illness and encephalitis in humans.2 The latter two according to the World Health Organization (WHO) are classified as biosafety Level 4 viruses.3 Hendra virus was identified as the causative agent of an acute respiratory disease in horses in 1994, and to date there have been only seven human infections with HeV, of which four were fatal (57%). Nipah virus was first identified during an outbreak of severe febrile encephalitis in Malaysia and Singapore in 1998 and 1999. Since then, several outbreaks of NiV have been identified in Bangladesh and India. There are two genetically distinct strains of NiV: the Malaysia strain (NiV-M) leads primarily to neurological symptoms with mortality rate of 40%, whereas the Bangladesh strain (NiV-B) leads to respiratory distress and a mortality rate of 90%. In India, the first NiV outbreak was reported in Siliguri town (2001), followed by outbreak in Nadia district (2007), Kozhikode (2018), and Kochi district (2019).4 The LayV was first identified in a throat swab sample from one febrile patient in eastern China through metagenomic analysis and subsequent virus isolation during sentinel surveillance of febrile patients with recent animal exposure. It has been detected in 35 people in eastern China between 2018 and August 2022, although the potential pathogen was detected only in 26. Most (85%) of the cases were farmers. The IgG titers in paired serum (acute and convalescent phases) obtained from 14 patients had four times higher titer in 86% of the convalescent samples. Acute LayV infection was associated with viremia, and patients with pneumonia had higher viral loads. In addition to causing respiratory symptoms, it can also cause fever, cough, fatigue and thrombocytopenia (35%), and leukopenia (54%), and impaired liver (35%) and kidney (8%) function are among the complications. Langya virus does not appear to spread between humans but is carried by shrews, which may directly or indirectly infect humans. Cases with no clear spatial or temporal aggregation have been reported indicating sporadicity.5 Langya virus, due to its closeness to Biosafety level 4 pathogens, should be considered equivalent posing a constant threat to livestock animals and humans until its entire pathogenic potential and epidemiology are understood. It remains crucial to monitor pathogen emergence to respond to pathogens with pandemic potential posing public health concern. Furthermore, robust laboratory diagnostics and a global surveillance system with rapid communication are urgently needed to detect such viral spillovers. 1193267 APHXXX10.1177/10105395231193267Asia Pacific Journal of Public HealthKour et al letter2023


Verification to validate designs is one of the important tasks in VLSI design flow. Due to the great advances in integration, verification for whole designs is getting more and more difficult. To solve this problem in early stages of design flows, we suggest a formal equivalence checking method for given two C-based hardware oriented specifications (C descriptions). To verify large C descriptions efficiently, we use textual differences in the two C descriptions and verify them in terms, of symbolic simulation. We believe that our approach will be useful where two specifications to be verified are very close, which is a very common situation in practical designs.


There is some evidence that indistinguishability obfuscation (iO) requires either exponentially many assumptions or (sub)exponentially hard assumptions, and indeed, all known ways of building obfuscation suffer one of these two limitations. As such, any application built from iO suffers from these limitations as well. However, for most applications, such limitations do not appear to be inherent to the application, just the approach using iO. Indeed, several recent works have shown how to base applications of iO instead on functional encryption (FE), which can in turn be based on the polynomial hardness of just a few assumptions. However, these constructions are quite complicated and recycle a lot of similar techniques. In this work, we unify the results of previous works in the form of a weakened notion of obfuscation, called Exploding iO. We show (1) how to build exploding iO from functional encryption, and (2) how to build a variety of applications from exploding iO, including all of the applications already known from FE. The construction in (1) hides most of the difficult techniques in the prior work, whereas the constructions in (2) are much closer to the comparatively simple constructions from iO. As such, exploding iO represents a convenient new platform for obtaining more applications from polynomial hardness.


Most studies of denitrification have focused on organic carbon as an electron donor, but reduced sulfur can also support denitrification. Few studies have reported nitrate (NO3−) reduction coupled with pyrite oxidation and its stoichiometry in surface sediments, especially without experimental pyrite addition. In this study, we evaluated NO3− reduction coupled with sulfur oxidation by long‐term incubation of surface sediments from a sulfide‐rich ecosystem in Akita Prefecture, Japan. The surface sediments were sampled from a mud pool and a riverbed. Fresh sediments and water were incubated under anoxic conditions (and one oxic condition) at 20°C. NO3− addition increased the SO42− concentration and decreased the NO3− concentration. SO42− production (∆SO42−) was strongly and linearly correlated with NO3− consumption (∆NO3−) during the incubation period (R2 = 0.983, P < 0.01, and n = 8), and the slope of the regression (∆NO3−/∆SO42−) and the stoichiometry indicated sulfur‐driven NO3− reduction by indigenous autotrophic denitrifying bacteria. Framboidal pyrite and marcasite (both FeS2) were present in the sediments and functioned as the electron donors for autotrophic denitrification. Both ∆NO3− and ∆SO42− were higher in the riverbed sediment than in the mud pool sediment, likely because of the higher amount of easily oxidizable S (pyrite) in the riverbed sediment. Consistently low ammonium (NH4+) concentrations indicated that NO3− reduction by dissimilatory NO3− reduction to NH4+ was small but could not be disregarded. Our results demonstrate that sulfide‐rich ecosystems with easily oxidizable metal‐bound sulfides such as FeS2 near the ground surface may act as denitrification hot spots.


The antihypertensive effect of four beta-blocking agents given once daily was compared with that of placebo in a prospective, crossover, double-blind study of 150 patients. The preparations tested were slow-release propranolol hydrochloride, 160 mg, atenolol, 100 mg, slow-release oxprenolol hydrochloride, 160 mg, and metoprolol, 200 mg. Propranolol and atenolol produced a significant decline in lying, standing, and postexercise blood pressure and pulse rate values. The effects of oxprenolol and metoprolol were not significantly different from that of placebo.


In the thermal dissociation of lithium monouranate, alpha -- Li/sub 2/ UO/sub 4/, the initial product is LiUO/sub 3/, followed by (Li,U)O/sub 2 /sub Px/. Lithium uranate (V) has a distonted perovskite type structure (rhombohedron) with lattice parameters (hexagonal) a = 5.406 0.001 kX and c = 7.506 0.004 kX. The (LiU)O/sub 2 /sub Px/ has a fluorite type structure, similar to uranium dioxide and other mixed oxides (Me,U)O/sub 2 / sub Px/. (R.V.J.)


The Swedish Obese Subjects (SOS) study was designed to compare outcomes in patients with obesity treated by bariatric surgery and a matched control group given usual care. The aim of this study was to analyze self‐reported weight‐loss methods and weight changes over 10 years in the SOS control group.


ABSTRACT Since its beginning in 2015, South Korean feminism has undergone profound and far-reaching changes, forming a pivotal moment. Amid this transition, mirroring holds central stage, revealing rampant misogyny. Gender issues, which were previously buried underneath the surface, were brought to the fore in Korean society. Online feminist groups mirror the hate speech and derogatory terms used for women, targeting them back at men with the intention of ridiculing the opposite sex. We conducted a series of ethnographic in-depth interviews with ordinary Korean women in their 20s who were exposed to mirroring and attempted to understand what mirroring meant to them. Our analysis revealed that mirroring does not simply mean releasing long-suppressed emotions; rather, it causes inner conflict among women. This, in turn, leads women to continuously educate themselves with respect to feminism, and to gather the strength to question deeply ingrained patriarchal norms. Although the sense of frustration and skepticism born of these conflicts that permeate oneself is inevitable; however, we mark this point as a new beginning in the journey to becoming a feminist as an ordinary woman in a society in which more tightly entwined patriarchal norms operate, encouraging their intense reflexivity and constant adaptability with the world.


As a new company, Gallaxery Enterprise provides designing and printing of banners, brochures and wedding cards. Set up with a better service and quality utilizing high technology of printing as an objective of the company distinguishes our company from the other companies. The industry profile involves the target market and industrial
prospect. The target markets are the event organizers, schools, companies and the public itself. While then, the industrial prospect of this business is creating an advertising platform for other parties to promote and advertise their events utilizing the printing technology. With high competency in targeting market, our vision is to manipulate printing industry in Senawang Commercial Park, thus, be the first company to provide services using high-tech in its range. Within 5 years, we are expecting to expend our business nature on publishing books as our long term mission. Our short term mission is to attract as many regular customers to deal with our company.


To transmits the compound images, it needs efficient compression methods because compound images has combination of text, graphics and natural image. The existing compression methods which contain, compound images are insufficient to compress because it contain text and graphics and natural images. This paper proposes a novel coding scheme from the H.264 intraframe coding. To overcome this problem we use two modes of intra coding methods. The first is the residual lossless scalar quantization (RLSQ) mode, where intra-predicted residues are directly quantized and coded without transform. The second is the base colors and index map (BCIM) mode that can be viewed as an adaptive color quantization. That the proposed scheme improves the coding efficiency even at most bit rates for compound images and it has very low complexity and provides visually lossless quality while keeping competitive compression ratios.


With the rapid development of China 's economy and the improvement of people 's living standards, skin care products have gradually become one of the most frequently used products in daily life. Consumer awareness rising skin care products market competition has become increasingly fierce, high-end market by foreign brands to seize skin care products become an indisputable fact. Under the impact of fierce market competition and international brands, how to develop domestic skin care products sustainably and healthily is a problem that many domestic skin care brands need to pay attention to. By combing the relevant literature of domestic skin care products, this paper makes a SWOT analysis of the domestic skin care industry, and analyzes the process of purchasing decisions of domestic skin care products by female consumers aged 18-25, so as to summarize the marketing strategies of domestic skin care products, retain old customers and attract new customers for domestic skin care products, and promote domestic skin care products to occupy more shares in the whole skin care market. Provide advice and inspiration, and provide some reference for the future development of local skin care product companies.


A comparison between the industrial structures of developed and Central and East European economies (CEEs) reveals that in CEEs Small & Medium Enterprises (SMEs) play a comparatively smaller role in corporate production networks, and are characterised by lower levels of innovation. This contributes to a lower level competitiveness and flexibility in CEE production networks, which justifies a research focus on the sources of this difference, and the identification of mechanisms to improve this aspect of CEE economies. We focus on Venture Capital firms (VCs) as an organisational form that can contribute to increased levels of innovation in CEE SMEs and increased levels of competitiveness in CEE production networks. In developed economies VCs play an important role in the identification and development of innovative SMEs and their integration in production networks. By contrast, in CEEs VCs are less important as a source of support for innovative SMEs. We distinguish two areas of interaction between VCs and corporate production networks: directly, through the sale of VC-backed firms to corporations, the use of VCs to develop corporate spin-offs and Corporate Venture Capital (CVC) programs ; and indirectly, through VCs facilitating science-industry technology transfer via their supportive role for the selection, development and integration in production networks of Higher Education Institutions (HEIs) spin-offs. In CEEs VC investments have so far been focused on SMEs that are readily integrated in MNE production networks, with very little interaction with domestic corporate production networks and HEIs. This type of investments have tended to be in late-stage companies characterised by low levels of innovation. We see this pattern of development as problematic, as the impact of MNEs is limited to SMEs that fit in with MNE strategies, which leaves out the possibility of developing innovative SMEs and strong linkages with domestic production networks. We identify two general areas where barriers to the further development of VC role in domestic industry. Firstly, domestic corporate strategies are characterised by low levels of linkages with SMEs, and low levels of technology development, and weak linkages with HEIs. In the VC industry this is manifested by little interest in purchasing innovative SMEs from VCs, few corporate spin-offs that could be supported by VCs, and no significant corporate venturing programs. Secondly, science-industry technology transfer policies remain underdeveloped, with weak technology transfer mechanisms. Consequently, the incentive systems, resources and organisational support are not in place that would allow the development of HEI spin-offs, which in turn has meant few avenues for linkages with VCs. We argue for the urgent need of formulation of policy measures in these two areas, in line with the overall policy maker concern with increasing the knowledge-intensity of CEE economies. This in turn necessitates further research focused on the problems we identify.


N THE political science literature called "behavioralist" which has emerged in the past twenty years, two distinct and incompatible approaches have been used. Mathematics has been employed for rank-ordering, for the computation of correlations, and for whatever other purposes numbers may serve. This method is analytical and reductionist and assumes the validity of mechanical cause-andeffect explanation. The other outlook is called "system theory" or "systems theory." Most commonly systems theory appeals to the analogy of organicist biology, which rejects the analytical and reductionist method and adopts a teleological perspective. Its origins are to be found in Aristotle, who believed that all of nature was purposive. The organicist or "organismic" view has been abandoned by virtually all twentieth-century biologists. An exception is Ludwig von Bertalanffy, who revived the organicist outlook in biology in the 1920s and generalized it into a cosmology in 1949.' Systems theory in social science derives from Bertalanffy's advocacy. Like its counterpart in biology, systems theory in social studies is frequently holistic rather than analytical, and ordinarily it seeks to answer the question "why" 2 in terms of function or purpose, in terms of goals, rather than in terms of antecedent propelling causes. The mechanical and organicist approaches are clearly incompatible, but it is very common for a single behavioral author to employ them both. A simulacrum of scientific method is presented in a discussion of cause-and-effect; but functionalist or organicist language is employed to suggest that what is at work is a teleological process. The best-known exponent of systems theory in political science is David Easton of the University of Chicago. The difficulties which result from mixing mechanism and organicism are clearly exemplified in Easton's work. Indeed, it is fair to say that unknown to Easton himself there are two David Eastons. One is a mechanist, the other a vitalist. We will call the former Easton I, the latter Easton II. As might be expected since Easton is oblivious to the mixture the organism Easton cannot be identified entirely with one or the other position at particular periods in the development of Easton's thought; these two incompatible strands compete in his work, with one predominating, then the other. As we will see, a final victory appeared to have been won by vitalism; nevertheless, Easton's presidential address to the American Political Science Association in 1969 his most recent statement concerning "behavioralism" shows that he believes he has been faithful to the assumptions of analytical science. In this same address, he claims for behavioralism a victory over other approaches to the study of politics. He cites his own work as part of a virtually completed "behavioral revolution" in political sci-


GPR56 (ADGRG1) is a member of a subset of G protein coupled receptors called adhesion GPCRs (AGPCRs). These GPCRs are unique in their possession of an autoproteolytic extracellular domain that cleaves the receptor prior to activation. GPR56 is a model AGPCR that couples to G12/13 family G‐proteins and we recently discovered that it functions as a platelet collagen receptor important for hemostasis. Based on experimental evidence thus far, we believe that GPR56 is a first‐acting collagen sensor for platelets – enabling them to first recognize blood vessel injury and to initiate the platelet program that leads to repair. Despite being biologically relevant in a number of cellular processes and diseases, there is a distinct lack of available small molecule tool compounds for AGPCRs, including GPR56. We conducted a large‐scale high throughput screen to find agonists and antagonists of GPR56. Over 160,000 compounds were screened in conjunction with UM's Center for Chemical Genomics (CCG) using a cell‐based serum response element (SRE) luciferase gene reporter assay in HEK293T cells. Primary screening yielded ~30 promising candidate full agonists and 8 candidate antagonists that robustly activated or inhibited GPR56 in cell‐based and biochemical assays. These compounds are currently being used in orthogonal platelet activation assays. Knowledge of these receptors is still sparse; the discovery of high affinity agonists and antagonists will be useful probes to explore AGPCR activities in endogenous contexts. These compounds may also serve as leads for the development of GPR56‐targeted pro‐ or anticoagulants.


AIM: To introduce the clinical experience of the use of cervical plexus block in behind-the-ear incision mastoidectomy. METHODS: Twenty-one patients, ASAⅠ-Ⅱ, aged 15-49 and scheduled for selective behind-the-ear incision mastoidectomy were under cervical plexus block during surgery. SBP, DBP, HR, SpO_2 and the effect of anesthesia were recorded. RESULTS: Satisfactory effects were obtained in 19 cases. No side effect and complications were observed in the 21 cases under study. CONCLUSION: Cervical plexus block for behind-the-ear incision mastoidectomy is a simple, convenient, safe and economical method.


Background Psoriasis is a complex autoimmune disease. Frequent interactions between epidermal and immune cells are likely to be responsible for the strong heterogeneity of psoriasis. Therefore, our work aims to build on current knowledge and further search for new molecular mechanisms related to psoriasis pathogenesis in order to develop new targeted drugs. Methods Data from psoriasis samples were obtained from the Gene Expression Omnibus (GEO) database, and batch effects were corrected using the "Combat" algorithm in the "SVA" package. Functional annotation of differential genes in psoriasis was performed by Gene set enrichment analysis (GSEA). Core functional modules were identified using the Multiscale Embedded Gene Co-Expression Network Analysis (MEGENA) algorithm for selection from the differential gene interaction network. The expression and potential function of Rh Family C Glycoprotein (RHCG) was predicted in single cell data by the "Seurat" package and validated in psoriasis samples by multiplex immunofluorescence. In addition, the regulatory function of HOP Homeobox (HOPX) on RHCG in keratinocytes was confirmed using RNA interference. Using immune infiltration analysis, RHCG and DC cells were analyzed for their association. Finally, the molecular mechanisms of treatment of psoriasis using Tripterygii Radix (TR) and Cinnamomi Ramulus (CR) were explored through network pharmacology and experimental validation. Results Immune response (represented by C1_2) and collagen matrix formation (represented by C1_3) were identified as two important pathogenic factors in psoriasis and helped to define new biological subtypes of psoriasis. One important psoriasis hub gene, RHCG, was obtained and found to be closely associated with keratinocyte differentiation as well as DC cell maturation. And RHCG was regulated by HOPX in keratinocytes. In addition, the mechanism of action of CR and TR in the treatment of psoriasis was tentatively confirmed to be related to TRPV3, NFKB2, and YAP1. Conclusions Our study identifies a new causal disease gene (RHCG) and offers potential alternatives for the treatment of psoriasis.


This thesis deals with two relatively new continuum percolation models, the Brownian interlacements and the Brownian excursions. Locally, these models look like a Poisson distributed number of transient Brownian motions. Due to the nature of these models classical techniques from percolation theory are often not applicable. More precisely, both models exhibit infinite range dependence. In the appended paper we study visibility in the vacant set of the Brownian interlacements, that is the existence of geodesic line-segments of some fixed length r contained in the vacant set, emanating from some fixed point. We give upper and lower bounds on the probability of the existence of such line segments in terms of r. We also consider the Brownian excursions model in the unit disk and show that it undergoes a non-trivial phase transition concerning visibility to infinity (in the hyperbolic metric). In Chapter 3 of the thesis we show that in the occupied region of Brownian interlacements the probability of having visibility in a fix direction of length r decays exponentially for intensities low enough. Finally, in Chapter 4 we prove that the vacant set of the Brownian excursions model in the unit disk has a non-trivial phase transition concerning percolation and that the distribution of the Brownian excursions can be described in a similar way to that of the Brownian interlacements.


By comparing with the control group, we evaluated the usefulness of contrast‐enhanced ultrasound (CEUS) combined with elastography for the assessment of muscle invasion by bladder cancer (MIBC) in a Sprague–Dawley (SD) rat model.


(1984), using confirmatory factor analysis, found that there were four dimensions to the scale rather than three. While retaining public self-consciousness and social anxiety, they found that private self-consciousness split into dimensions of "self-reflectiveness" (the disposition to think about oneself) and "internal state awareness" (awareness of inner feelings and states). Given these results, a smdg was done with a convenience sample of 169 adults (77 men and 92 women) in a large, Northeastern metropolitan area to investigate the construct validity of this widely used scale. The age range of the sample was 21 to 75 yr. (M = 34.6, SD = 11.6). It is believed that the sample is representative of the lower to middle range of the middle class which is the range of the students who collected the data, although no further assessment was made. For collecting the data, students received a credit of six points on one examination. Names and telephone numbers were also collected for each of the respondents on a separate list which protected their anonymity and about 15% were called to affirm that they had participated in the survey. Confirmatory factor analysis (LISREL VI) was used in the analysis. The lowest goodness of fit index of .792 was obtained for the original three dimen


I am holding in my hand a rather new booklet, a booklet1 aiming to advise teachers in schools and kindergarten on how to treat Roma children in a correct and culturesensitive manner. The book aims at reducing barriers of cross-cultural understanding, and making teachers familiar with the Finnish Roma culture. The authors of the booklet underline that the Roma in Finland do have a different culture than the majority. Knowing this culture makes it easier for the teacher to take special care of the Roma child so that she or he will feel comfortable in the kindergarten and school. On page four of the booklet it explains that in Roma families there is a very traditional gendered sharing of household-work: women take care of the kitchen and house and men earn the living. On page six taboo topics are listed and the reader is informed that such issues as sexuality and normal physical activities should not be spoken about. The Finnish Roma are also told to have a different understanding of time, and this should be known by teachers. The booklet goes through specific features of Roma culture and also covers the term of 'avoiding'. When a Roma kills or hurts another Roma, the perpetrator's family needs to avoid by all means the family of the victim: this is explained as a means to pay respect to the victims' family and therefore, it is noted, for example that children of the two families cannot attend the same school or kindergarten. After the rather culturalising tone of the booklet, it then stresses on page eight that 'Not all Roma children are bound by culture!' What does this kind of booklet tell us about Finnish society, the inhibited understandings of differing cultures within and its approach towards minority cultures? This article discusses power relationships tied to the differing status positions of minority groups in a society in which decision-making is based on consensus: It addresses the ambivalence in a polity torn between a strong governmental (and societal) commitment to shared power in the name of equality and a weak inclination toward accommodation of diversity. The empirical material stems from research with two national minorities in Finland, the Sámi and the Roma. The main question concerns participation in the creation of the agenda behind decision-making processes: why certain interests (of minorities) do not find a way


This study was conducted due to the absence of physics teaching materials containing local wisdom at Hulu Sungai Selatan―a regency in South Kalimantan, Indonesia, and the less optimization of character building in the learning process. Therefore, Research and Development (R&D) of local wisdom-based teaching materials of physics at Hulu Sungai Selatan was conducted. This study aimed to develop effective and applicable local wisdom-based teaching materials of physics in terms of validity, practicality, effectiveness and attainment of rakat mufakat character at Hulu Sungai Selatan for physics learning. This study was Research and Development (R&D) using ADDIE model. The samples of this study were the students of class XI IPA 2 at SMA Negeri 1 Angkinang. The data were obtained from validation sheet, response questionnaire, achievement test and peer assessment on rakat mufakat character. The results of this study revealed that: (1) the teaching materials of physics were valid based on the content validation sheet and the presentation of the module, (2) the teaching materials of physics were very practical based on the students' response questionnaire, (3) the teaching materials of physics were moderately effective based on the results of the achievement test, and (4) the rakat mufakat character was built very well based on the peer assessment. Based on the results of this study, it was concluded that the local wisdom-based teaching materials of physics at Hulu Sungai Selatan were effective and applicable to physics learning.


In this paper, a joint spectrum sensing and user selection strategy based on energy detection through data fusion is investigated, considering the weight vector, the sensing time and the optimal user set. The optimal sensing time and the weight vector for data fusion are calculated by equivalent transformation algorithm. Moreover, the user selection strategy based on Modified Deflection Coefficient (MDC) with low complexity is proposed, from which the optimal number and the user set are obtained to provide sufficient protection to the primary user and improve the total throughput of the cognitive radio network. The simulation results show that the optimal number of cognitive radios and maximal normalized sensing throughput can be obtained by the proposed method.


Flumes with either width contractions or raised beds to force modular flow conditions (i.e. a transition from sub-to super-critical flow) are a widely used instrument for the measurement of flow rate. The conservation of mass, written as the continuity equation, and the conservation of energy are combined with the existence of a critical depth point to derive a theoretical equation for the discharge as a function of the upstream water depth. This derivation requires a number of assumptions regarding the flow both upstream and in the throat of the contraction. The international standard covering the use of such flumes, ISO4359, places restrictions on the upstream position at which the water depth should be measured, which this work shows to be unnecessary, at least for the small (100mm throat width) flumes examined. The assumption that critical depth occurs at the end of the flume throat is also shown to be incorrect, but has negligible effect on discharge calculation using the ISO4359 method.


We introduce process spaces as a new abstraction for the definition of a process metaphore over various (heterogeneous) information systems in an enterprise, which are not necessarily process-aware, and propose the design and development of process spaces management systems (PSMSs), which provide support for the discovery, analysis, monitoring, querying, and exploration of process spaces. We also present our current research progress towards the development of a PSMS, which is the design and development of a system, called process spaces discovery system, for the discovery of the process space of an enterprise.


This study describes the variations in the chemical composition of the exhaust at various equivalence ratios (air-fuel ratios) when pure diisobutylene (2,4,4-trimethyl-l-pentene) is used as a fuel in a Labeco single cylinder engine. The exhaust hydrocarbon products from diisobutylene consist of two types: those which decrease as the equivalence ratio is increased: methane, ethylene, acetylene, diisobutylene; and those which exhibit a maximum near an equivalence ratio of 1, then decrease: propylene, propadiene, isobutyl-ene, ethane, 2-methyl-l-butene. The combustion of diisobutylene produces two olefins in low yield which are not observed in the combustion of isooctane fuel. These are 2,4-dimethyl-l,3-pentadiene, probably derived from pyrolytic decomposition of C7-alkyl radicals, and 3,5,5-trimethyl-2-hexene, probably arising from methyl radical addition to the alpha carbon of the parent fuel molecule. Comparison of the photochemical reactivity of dissobutylene exhaust to that of isooctane at a fuel-lean c...


We have introduced a innovative idea of sectorization of Full DST transformed components. In this paper we have proposed two different approaches along with augmentation of mean of zeroeth and highest row and column components of Full DST transformed image for feature vector generation. The sectorization is performed on two different planes namely Even plane and Even plane. We have introduced the new performance evaluation parameters i. e. LIRS and LSRR apart from precision and Recall, the traditional methods. Two similarity measures such as sum of absolute difference and Euclidean distance are used and results are compared. The cross over point performance of overall average of precision and recall for both approaches on different sector sizes are compared. The DST transform sectorization is experimented on Even and Even plane components of transformed image with augmentation and without augmentation for the color images. The algorithm proposed here is worked over database of 1055 images spread over 12 different classes. Overall Average precision and recall is calculated for the performance evaluation and comparison of 4, 8, 12 & 16 Full DST sectors. The use of sum of Absolute difference as similarity measure always gives lesser computational complexity better result of retrieval.


The use of innovative technologies is the most effective and promising way to improve the road traffic safety management system. The relevance of the work is expressed in the need for continuous implementation of innovations in the context of growing disproportion between the sharp increase in the number of vehicles, high traffic intensity, and imperfection of road traffic management (problems of existing infrastructure, poor information support for road users, etc.), which results in road traffic injuries and deaths. In the course of the research, it was found that in the context of the Republic of Adygea, using rumble strips installed at the road shoulder reduces the number of run-off-road collisions by 30%, while using centerline rumble strips reduces the number of cross-over incidents and resultant head-on collisions by 15%


Depositions were performed from bulk targets of nominal composition YBa/sub 2/Cu/sub 3/O/sub 7-//sub delta/ by CO/sub 2/ laser evaporation and excimer laser ablation. The substrates selected were Al/sub 2/O/sub 3/ and SrTiO/sub 3/. The principal deposition parameters varied were substrate temperature and O/sub 2/ pressure. The resulting films were characterized by XPS and resistivity measurements. For the best film, the superconducting onset temperature was 95 K with completion by 62 K. This film was deposited by excimer laser onto a SrTiO/sub 3/ substrate at 440/sup 0/C in 2 mTorr of O/sub 2/. Some anomalous low temperature resistivity behavior in the thinner films (<440 nm) or SrTiO/sub 3/ is also described.


In this work the
reconstruction of a tau neutrino signal in the KM3NeT detector is discussed.
Tau neutrinos leave a two shower signature in the detector, which is a unique
signature among all neutrino interactions. By identifying and reconstructing
these tau signatures the KM3NeT detector will be able to distinguish all three
neutrino flavors. In addition, cosmic tau neutrinos suffer significantly less
from atmospheric backgrounds, makign them ideal messengers for cosmic events.
The presented reconstruction is the first tau reconstruction for the KM3NeT
detector and resulted in a total expected observation rate of half a tau event
per year for one unit of the KM3NeT detector.


A simplified axisymmetric lattice Boltzmann method (SALBM) is developed in this paper for effective simulation of incompressible swirling and rotating flows. This model explores an alternative approach of reconstructing an axisymmetric model within the lattice Boltzmann (LB) framework. Essentially, SALBM reconstructs solutions to the macroscopic governing equations recovered from the axisymmetric LB equation through the Chapman-Enskog expansion analysis. Two variations of schemes, which bear different orders of temporal accuracy and are, respectively, suitable for the steady and the unsteady axisymmetric flow problems, can be evolved from SALBM. The proposed schemes reflect direct evolution of macroscopic variables instead of distribution functions, which could reduce the cost in virtual memory. Meanwhile, analytical interpretation of physical boundary conditions is available in SALBM which avoids tedious transformations as required in conventional LB models. Numerical tests further reveal that SALBM performs better than the existing axisymmetric LB models in numerical stability. These merits endow the present SALBM with advantages over previous models and forge its prospect in engineering applications.A simplified axisymmetric lattice Boltzmann method (SALBM) is developed in this paper for effective simulation of incompressible swirling and rotating flows. This model explores an alternative approach of reconstructing an axisymmetric model within the lattice Boltzmann (LB) framework. Essentially, SALBM reconstructs solutions to the macroscopic governing equations recovered from the axisymmetric LB equation through the Chapman-Enskog expansion analysis. Two variations of schemes, which bear different orders of temporal accuracy and are, respectively, suitable for the steady and the unsteady axisymmetric flow problems, can be evolved from SALBM. The proposed schemes reflect direct evolution of macroscopic variables instead of distribution functions, which could reduce the cost in virtual memory. Meanwhile, analytical interpretation of physical boundary conditions is available in SALBM which avoids tedious transformations as required in conventional LB models. Numerical tests further reveal that SALBM perf...


In a collaborative design process, design activities, people and design tools are connected each other for collaboratively finishing design tasks. A method based on complex network theory is proposed in this paper to analyze the performance of the process. Firstly, the collaborative design process is abstracted as a network named collaborative design network (CDN), and its elements of CDN, such as nodes, edges and weight of edges are defined. Then the topological and physical characteristics of the CDN are defined and analyzed for revealing its performances. Finally, a steam turbine rotor design process is studied as an example to illustrate the feasibility and availability of the proposed method.


This business plan goal is to offer a restaurant service, in the north of Quito city, Ruminahui neighborhood, this restaurant is designed for families, students and companies working nearby. The name of the restaurant is "La Abuelita Lojana", and the VISION is "Becoming in three years, the first option in food offerings in the neighborhood Ruminahui, focused in a variety of Loja cuisine. Our main commitment is to appeal the customers experience palate", and the MISSION is "Be a new and different food alternative for Ruminahui neighborhood, rescuing the culinary tradition of the city of Loja, combined with excellent service and quality, thus achieving customer loyalty ". The project objective is be a new and different food alternative for Ruminahui neighborhood, rescuing the culinary tradition of the city of Loja combined with excellent service and quality, thus achieving customer loyalty to the restaurant. This project will have a building, equipment, furniture and the decoration according to the culture and diversity that exists in the city of Loja. With the help of the financial study, it will be possible to get an idea of the profitability of the project and potential income it would generate given their execution. All relevant areas were quantified and income calculated, indicating the projected profitability.


The response of M. halmaturorum was measured to determine the ability of juvenile plants to survive flooding and to examine how this influenced plant growth. Seedlings and one- and two-year-old plants were flooded to 0% (control), 50% or 100% of their initial height for periods of three to 14 weeks, followed by an eight-week recovery period. Only 22% of seedlings survived five weeks of 100% coverage, but these died during the recovery period. The older plants survived the flooding treatments well, but as duration increased so survival through the recovery period declined. After 100% coverage for six weeks followed by the recovery period, only 29% survived. Stem linear extension rates corresponding to these survival rates were used to predict the survival of juvenile M. halmaturorum in Bool Lagoon, South Australia. The results showed that, with the current water regime, natural recruitment would occur only at the highest elevation but that this could be improved by planting older, taller plants at lower elevations. Indices of growth showed that flooded plants performed poorly compared with the controls as duration and percentage of coverage increased. The data suggested that coverage inhibited plant growth during the flood period, but there was a further, interactive response to duration that became apparent after the post-flood recovery period. An interpretation of these results is that M. halmaturorum in its juvenile stages is intermediate between a flood-sensitive and a flood-tolerant species because it is able to recover from short floods of three weeks or less but performs poorly if floods exceed six to nine weeks.


Adiabatic or slowly varying gate operations are typically required in order to remain within the qubit subspace in an anharmonic oscillator. However significant speed ups are possible by using the two quadrature derivative-removal-by-adiabatic-gate(DRAG) technique, where a second time derivative pulse component burns a spectral hole near an unwanted transition. It is shown here, that simultaneous optimization of the detuning and the pulse norm in addition, further reduces leakage errors and significantly improve gate fidelities. However, with this optimization accounting for the AC Stark shift, there is a low spectral weight pulse envelope regime, where DRAG is almost not needed and where the two state error fidelities are stable against pulse jitter. Explicit time evolution calculations are carried out in the lab frame for truncated multi-level Transmon qubit models obtained from a tight-binding model.


Biomediccal research has learned that the real and imaginary parts of the complex impedance of human tissue contain abundant information of physiology and pathology. While the imaginary part of the complex impedance information is so weak that it is difficult to obtain. However,it becomes easy to acquire imaginary part when the excitation frequency reaches above 1 MHz. Aiming at this problem,this paper designed a bio-electrical impedance tomography system hardware based on CAN bus. The system hardware makes the excitation frequency extend to 10 MHz. Digital synthesizer- AD9852 is adopted to provide the clock signal of uniform for data acquisition boards. Every data acquisition board uses 16 bit,1MSPS differential ADC- AD7677 to acquire data,and high frequency waveforms are sampled by using multi-cycle undersampling technology. At last,the real and imaginary parts of complex impedance are calculated by adapting digital phase sensitive demodulation technique.


Before 1782 little more than a 'partial agglomeration' of platinum had been achieved, mainly by hot forging from the powder which, although it sufficed to make many platinum artefacts, did not produce homogeneous molten metal (1–3). The first to melt impure platinum may have been Henrik Theophil Scheffer (1710–1759) who in 1751 melted platinum with copper, and later arsenic, in a furnace (4). Franz Achard (1753–1821) similarly melted the metal with arsenic (5). In both cases alloys of platinum, rather than pure platinum, are likely to have been melted. In 1775 Pierre Macquer (1718–1784) and Antoine Baumé (1724–1804) unsuccessfully attempted to melt platinum in a porcelain crucible over a wood fire. Macquer and others (later including Lavoisier) then tried with burning glasses: a 56 cm diameter concave mirror which focused the sun's rays quickly melted iron but platinum gave only silverywhite glistening particles – the product probably contained impurities of carbon which lowered its melting point (1). In 1774 a magnificent 1.2 m diameter burning glass filled with alcohol was mounted on a carriage and installed in the Jardin de l'Infante, Paris, France: it melted many materials, but not platinum (1, 6). An illustration of this device is shown in Figure 1 (3).


I show that conventional estimators based on the consumption Euler equation, extensively used in studies of intertemporal consumption behavior, produce inconsistent estimates of the effect of children on consumption if potentially binding credit constraints are ignored. As a more constructive contribution, I supply a tractable approach to obtaining bounds on the effect of children and a structural estimation strategy when households face constraints. Finally, I estimate the effect of children on consumption using the Panel Study of Income Dynamics (PSID) for the US and high quality Danish administrative register data. Results suggest that children does not affect household consumption in the same magnitude previously assumed.


Abstract A digital control system has been investigated for converter-fed synchronous motors particularly in high power applications. Improved system ruggedness is ensured using subtransient flux reference synchronization. A simplified model of the converter-fed synchronous motor is studied and the optimal torque performance is determined. The proposed microprocessor-based control system is discussed in detail. Transient behaviour of the system is tested experimentally.


Report describes use of electrochemical impedance spectroscopy (EIS) to investigate resistances of 19 alloys to corrosion under conditions similar to those of corrosive, chloride-laden seaside environment of Space Transportation System launch site. Alloys investigated: Hastelloy C-4, C-22, C-276, and B-2; Inconel(R) 600, 625, and 825; Inco(R) G-3; Monel 400; Zirconium 702; Stainless Steel 304L, 304LN, 316L, 317L, and 904L; 20Cb-3; 7Mo+N; ES2205; and Ferralium 255. Results suggest electrochemical impedance spectroscopy used to predict corrosion performances of metal alloys.


Background: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has complicated the management of inflammatory bowel diseases (IBD). Objectives: This study aimed to assess the efficacy of different anti-SARS-CoV-2 vaccines under different treatments in IBD patients and identify predictive factors associated with lower serological response, including anti-tumor necrosis factor (anti-TNF) drug levels. Design: A prospective, double-center study of IBD patients was conducted following messenger ribonucleotide acid (mRNA) and non-mRNA anti-SARS-CoV-2 vaccination. Methods: Healthy control (HC) patients were enrolled to reduce bias. Baseline and control samples were obtained 14 days after the second dose to assess the impact of conventional and biological treatments. Clinical and biochemical activity, serological response level, and anti-TNF drug levels were measured. Results: This study included 199 IBD (mean age, 40.9 ± 12.72 years) and 77 HC participants (mean age, 50.3 ± 12.36 years). Most patients (76.9%) and all HCs received mRNA vaccines. Half of the IBD patients were on biological treatment (anti-TNF 68.7%). Biological and thiopurine combined immunomodulation and biological treatment were associated with lower serological response (p < 0.001), and mRNA vaccination promoted better antibody levels (p < 0.001). Higher adalimumab levels caused lower serological response (p = 0.006). W8 persistence of anti-SARS-CoV-2 level was equal in IBD and HC groups. Vaccination did not aggravate clinical disease activity (p = 0.65). Conclusion: Anti-SARS-CoV-2 vaccination is considerably efficacious in IBD patients, with mRNA vaccines promoting better antibody levels. The negative impact of combined biological treatment, especially with high adalimumab drug levels, on serological response to vaccination should be considered. Although midterm durability of vaccination is encouraging, more data are needed to expand the existing understanding on this issue.


Changes in bubble chirality are investigated using transient photography in order to determine the rotation of the azimuthal angle, either ψ or ψ, during radial motion. The critical rotation required to change chirality is determined experimentally to be near ψ=π. The Walker model, which predicts a critical rotation of π/2, cannot be used to describe radial motion. Instead, the horizontal Bloch line model, in which chirality changes occur during HBL punch‐through when ψ reaches nπ, must be used. The first seven values of the minimum step amplitude, Hn, required to produce exactly n chirality changes during a single bias step are given, within ±0.2 Oe, by Hn=[2vsH′ (γ)−1]1/2(nπ)1/2+Hs, where vs is the constant wall velocity, H′, is an effective field gradient, and Hs is an effective drag field. A 30‐nsec pause in the wall motion, observed when ψ reaches π, is thought to be due to the large effective gyrotropic field produced during punch‐through. Contrary to the HBL stacking mechanism, punch‐throug...


A drift chamber type radiation detector is being used to examine design criteria for a new type of detector called a micro Time Projection Chamber (micro TPC) which is being proposed for use in high energy nuclear physics experiments. The main advantage of the micro TPC detector is its very low radiation thickness compared to its silicon counterpart. The micro TPC is a charged-particledetector which willbe optimized for good two track resolution whichis needed in a high track density environment. Such performance requires low electron diffusion and high resolution readout. The diffusion willbe reduced by limiting the drift distance to 15 cm and by using a low diffusion gas such as dimethyl ether. High resolution willbe obtained by using a new readout technology called microstrips. Microstrips are a recent development using photolithographytechniques that allow the creation of anodes a fewmicrons in width with submicron precision. The main purpose of this test chamber is to demonstrate the feasibility of a micro TPC design using a low diffusion gas and to insure the sufficient signal remains after electron attenuation. The drift chamber design and the proposed testing procedures are described.


The pre-treatment of alder and triticale at yellow ripeness and ripe by using steam explosion was investigated. Besides, the authors analysed the influence of steam pressure (from 20 to 22 bar), reaction time (from 180 to 240 s) and sulphuric acid strength (from 0 to 0.5%) on the pre-treatment and contents of monosaccharides (glucose, arabinose, xylose, mannose) and undesirable compounds (furfural and HMF) in hydrolysate. The greatest amount of dry matter is found in the hydrolysate of triticale of yellow ripeness (18.8%) when the strength of sulphuric acid is 0.5%, steam pressure– 20 bar and reaction time 240 s. The greatest amount of useful monosaccharides used in bioethanol production such as glucose 6.1%, arabinose 1.1%, xylose 8.8% and mannose 0.8% were received from alder when the steam pressure was 22 bar, reaction time 240 s and the catalytic sulphuric acid strength 0.5%. The extraction of useful monosaccharides from alder was from 2.0 to 4.0 times less than from the ripe triticale at the same parameters of hydrolysis.


The aim of my thesis is to give an overview, from different angles, on issue of inventory, tangible and intangible assets. The thesis analyses current state of accounting records and files related to these assets in a company that wanted to stay in anonymity and which I have decided to call Obchod a.s. The analysis should discover imperfections in files and internal regulations of these assets and their influence on the financial outcome. On the basis of the study, I would like to suggest the company changes in accounting records focused on these assets, which will lead to increased efficiency (save of labour) and will avoid mistakes in this field. In the last part, I would like to prepare the accounting system of the company cover-ing the area of tangible, intengible assets and invetory to transformation to international accounting standards, the result is the balance sheet arranged according the IFRS.


Cardiovascular risk factors for the development of cognitive impairment and Alzheimer's disease are ranked among the most significant ones, especially in elderly patients. The review provides data on the influence of such factors as arterial hypertension, arterial hypotension, heart failure, coronary heart disease, etc. on the development of cognitive deficiency. The presence of two or more of these risk factors generally tends to increase the possibility of the development of Alzheimer's disease. The author examines the relationship between these factors and the development of Alzheimer's disease. Insights into how CVD risk factors can cause progressive cognitive impairment provides further insight into the pathophysiology of Alzheimer's disease and the identification of methods to prevent or treat CV risk factors for cognitive decline. The course and outcome of cardiovascular diseases depend on the patient's age, previous medical history, lifestyle, primary prevention, genetic and pathological factors that affect structural and hemodynamic functions. The article addresses issues of therapy of these disorders. Methods of non-pharmacological therapy are discussed: the importance of the patient's lifestyle, physical activity, nutritional issues, social activity of patients. Much attention is paid to the role of cognitive training in the management of patients with cognitive impairments. The correction of risk factors for stroke and the progression of chronic circulatory disorders is one of the most elaborated areas. The therapeutic potential drugs with a multifactorial mechanism of action are discussed. One of them is Ginkgo biloba extract EGb 761®, which meets the regulated content of active ingredients (flavone glycosides, terpene lactones and ginkgolic acid) and, perhaps, promises to be a more rational choice in the treatment of cognitive impairment. The role of Ginkgo biloba extract EGb 761® in the treatment of cardiovascular diseases is discussed.


Intensities of 16 beams of near normal incidence positrons have been measured at T=120 K and analyzed using a multiple scattering model of the low‐energy positron diffraction (LEPD) process. Excellent correspondence between the measured and calculated intensities is obtained for a reconstruction that is primarily a bond‐length‐conserving rotation of the top layer, with As relaxed outward and Ga inward with a tilt angle ω1 = 28.6 ± 3°, confirming the results of previous structure analyses for this surface. The quality of the description of the measured intensities, as measured by the x‐ray R factor, is significantly better for LEPD than for low‐energy electron diffraction. This result is attributed to the repulsive character of the positron‐ion core potential and a resulting more surface sensitive diffraction process for LEPD.


differential effects both on ligand binding and ligand-induced Notch3 receptor signaling through RBP-Jk. Exp Cell Res 2004;299:454e64. 24. Unlü M, de Lange RP, de Silva R, et al. Detection of complement factor B in the cerebrospinal fluid of patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy disease using two-dimensional gel electrophoresis and mass spectrometry. Neurosci Lett 2000;282:149e52. 25. Rafalowska J, Dziewulska D, Fidzianska A. CADASIL: what component of the vessel wall is really a target for Notch 3 gene mutations? Neurol Res 2004;26:558e62. 26. Jurynczyk M, Jurewicz A, Raine CS, et al. Notch3 inhibition in myelinreactive T cells down-regulates protein kinase C theta and attenuates experimental autoimmune encephalomyelitis. J Immunol 2008;180:2634e40.


E. coli is a fecal indicator that is useful to predict sanitary risk in water. Therefore, it is of interest to establish systems which are capable to monitor its concentration at realistic conditions. One possibility is to use molecularly imprinted polymers providing a selective surface binding attachment of E. coli. Bacteria imprinted polymer beads were synthesized via Pickering emulsion polymerization. In this process, E. coli served as a stabilizer to form a stable emulsion during radical initiated polymerization of styrene and DVB. Scanning electron microscopy revealed polymer beads before washing contain E. coli on their surfaces. After washing, imprints in the shape of E. coli are visible on the surface. Those beads are inherently useful for rebinding and thus selective filtration and pre-concentration of E. coli prior to sensing.


We have designed and constructed an 8 channel system for the analog processing, the digitization, the digital processing and acquisition of signals from CdTe / CdZnTe discrete detectors. The system consists of: Discrete charge preamplifiers, discrete semi-Gaussian shapers, 8 A/D converters working in parallel, FPGA for the pre-processing of the digital signals, high voltage module, USB link for the PC and software. The detectors can be packaged together with a JFET front end transistor and plugged in the mother board which contains the rest of the charge amplifiers, the shapers and single to differential signal converters. The system can be used for the characterization of the detectors or as a portable instrument for spectroscopy.


This paper introduced the methods and characteristics of afforestation monitoring of Sino-German cooperative forestry project,and analyzed the problems of afforestation monitoring of forestry projects in China,finally,put forward the measures to solve the problems.


To assess the ability of ultra‐short echo time (UTE)‐MRI to detect subglottic stenosis (SGS) and evaluate response to balloon dilation. To correlate measurements from UTE‐MRI with endotracheal‐tube (ETT)‐sizing and to investigate whether SGS causes change in airway dynamics.


Horizontal oscillations of small droplet clusters (from one to four droplets) levitating over a locally heated water layer in upward vapor–air flow are investigated experimentally. These oscillations are caused by a complex dynamic interaction between the droplets and the nonsteady gas flow. The path of the center of the droplet cluster is similar to a random walk in a potential well. The vibrational spectra of clusters' centers obtained by Fourier analysis showed several frequency peaks between f = 1.61 and 5.96 Hz found in all clusters, which shows that the cluster tends to oscillate as a whole. The possibility of decoupling of the aerodynamic interaction between the gas flow and the droplets and the interaction between individual droplets is discussed.


Background The systemic therapy is currently recommended for patients with oligometastatic prostate cancer, however the prognosis has not been satisfactory. Therefore, it is necessary to explore more effective treatment to improve the prognosis. Oligometastatic prostate cancer is a special subgroup in patients with advanced cancer. The paragrim of treatment is shifting to a more aggressive approach. Stereotactic body radiotherapy (SBRT) is an emerging treatment alternative for patients with oligometastases with minimal toxic effects. What's more, accumulating studies have proved safety as well as feasibility of radical prostatectomy and local or metastasis-directed radiotherapy for oligometastatic patients. The aim of this phase I prospective trial is to demonstrate the early evidence of safety and feasibility of metastasis-directed radiation and neoadjuvant hormone and radiation therapy followed by radical prostatectomy for treating oligometastatic prostate cancer Methods The patients with oligometastatic prostate cancer received 1 month of neoadjuvant androgen deprivation therapy (ADT) followed by metastasis-directed radition and abdominal or pelvic radiotherapy. Then offer radical prostatectomy at the interval of 4-8 weeks after radiotherapy and adjuvant ADT for 2 years. The primary endpoints of the study are safety as assessed by CTCAE 5.0 grading scale and intraoperative and postoperative day-30 morbidity. Secondary endpoints include the positive rate of post-operative edge, biochemical progression-free survival (bPFS), postoperative continence and sexual function recovery, quality of life (QoL), overall survival (OS) and adverse reactions of ADT. Discussion This is the first, phase I trial assessing the safety and feasibility of metastasis-directed radiation and neoadjuvant hormone and radiation therapy followed by radical prostatectomy treatment for patients with oligometastatic prostate cancer. If positive, the results of this trial may help to design subsequent phase II trials exploring the role of metastasis-directed radiation and neoadjuvant hormone and radiation therapy followed by radical prostatectomy in the randomized controlled study.


Antiserum against transmissible gastroenteritis virus(TGEV) M protein was prepared by immunizing New Zealand rabbits with the purified recombinant TGEV M protein.Antibody titer determined by the indirect ELISA was 1∶14000.Results of the indirect ELISA showed that the antiserum was highly specific to TGEV.In the indirect immunofluorescent test strongly yellow and green fluorescence was displayed in the cytoplasm and membrane of IBRS cells infected with TGEV,but no fluorescence was showed in cells which were not inoculated with TGEV.These results showed that the antiserum against the recombinant TGEV M protein was specific for the detection of the pathogen,which provided the material foundation for accurate and rapid diagnosis of TGEV.


Previous studies have shown that reserpine (1 mg/kg ip) completely blocks insulininduced growth hormone (GH) release. The possibility that the suppressive action of this drug on GH secretion might be due to its catecholaminedepleting action was investigated in the present experiments. α-Methyldopa (300 mg/kg ip), amethyl- m-tyrosine (300 mg/kg ip), or tetrabenazine (15 mg/kg ip), like reserpine, were effective in suppressing the release of GH induced by 2 U/kg of insulin. Guanethidine (30 mg/kg ip) and tyramine (15 mg/kg ip) were without effect. The blockade of GH release induced by reserpine (1 mg/kg ip) was reversed by iproniazid (150 mg/kg sc). After reserpine treatment (1 mg/kg ip), the release of growth hormone-releasing factor (GRF) from the hypothalamus induced by insulin (2 U /kg ip) was abolished. From these experiments it is concluded that: 1. The reduction of stores of brain norepinephrine impairs GH release; 2. brain amines might play a role in the release of hypothalamic neurohumoral transmit...


The use of quality seeds can increase the production of garlic. One indicator of increased yield can be seen from the size of cloves. The research aimed to know the growth and production of garlic from clove size and different seeds storage method. The experiment was conducted at Experimental farm Berastagi that began February-June 2018. The experiments was arranged in Randomized Complete Block Design with two factors. The first factor is the size of cloves, namely: 2.3 g / clove, 1.4 g / clove, 0.7 g / clove and the second factor is the storage method of separation of tubers and separation of cloves.. The observed variables include plant height, leaf number, leaf length, stem diameter, tuber weight, tuber diameter, number of cloves, and ability to grow. The results showed that storage method had significant effect on percentage of germination seed. Clove weight and storage method not significant effect on plant height, leaf number, leaf length, neck diamter, tuber weight, tuber diameter and number of cloves. Interaction occurs between treatments the neck diameter of garlic


In this paper we discuss aesthetical concepts and requirements for reasonable multiple test procedures. Aesthetical considerations lead to logical decision patterns which are conceivable and, if possible, simple to use and to communicate. Such considerations are sometimes contradictory to the ubiquitous requirement of maximizing power for a multiple test procedure. We illustrate the necessary trade‐offs with several examples. We start by considering important logical properties and then discuss three different concepts of monotonicity. Afterwards we have a closer look at the recently proposed "fallback procedure" and show that it has some less appealing properties. Finally, we investigate the distribution of the numbers of significant results with respect to both expectation and variance. (© 2008 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)


This paper examines how gastronomic journalism is related to Brazilian contemporary consumer culture. Therefore, we resort to concepts such as imaginative hedonism (Campbell); taste, distinction and lifestyle (Bourdieu); and renovation of desire by fashion (Lipovetsky). The corpus includes the section Food of Folha de S. Paulo newspaper, a pioneer as an independent section about this subject published between 1988 and 1992 and reissued in 2011. The cultural phenomenon of gastronomy is observed in the context of the growing of the middle class in the country, when more people start eating out and thinking more about what they eat, looking for information on the subject to guide their choices.


High mobility phonon-glass semimetal $CuAgSe$ has shown promise in recent years as a potential low-temperature thermoelectric material. It exhibits reasonably strong thermoelectric performance as well as an extremely high carrier mobility, both of which are enhanced when the material is doped with Ni at the Cu sites. The exact mechanism by which these enhancements result; however, is unclear. In order to further investigate the effects of chemical substitution on the material's thermoelectric properties, we have prepared and performed various measurements on $CuAgSe$ samples doped with Co and Cr according to the following compositional formulas: $Cu_{1-x}Co_{x}AgSe$ $(x=0.02, 0.05, 0.10)$ and $Cu_{1-x}Cr_{x}AgSe$ $(x=0.02, 0.05)$. Measurements of temperature and magnetic field dependent thermal conductivity, electrical resistivity, and Seebeck coefficient will be discussed. Our results reveal a remarkable sensitivity of $CuAgSe$'s thermoelectric properties to chemical doping in general as well as a particular sensitivity to specific dopants. This demonstrated tunability of $CuAgSe$'s various properties furthers the case that high mobility phonon glass-semimetals are strong candidates for potential low temperature thermoelectric applications.


ward transport of the UHP rocks under eclogite facies conditions, monitored by blastesis of primary pargasite, occurred at different time and in different geodynamic setting. In the eclogites no fabric can be assigned to the mineral relicts of the UHP event, thus deformation at the extreme P-T conditions remains undeciphered. A pronounced metamorphic layering expressed by garnet-rich/garnet-poor and occasional pargasite layers developed during the HP syntectonic eclogitic metamorphism. The earliest recognizable deformation in eclogites is marked by asymmetric aggregates of garnet or pyroxene, with pargasite in pressure shadows and by oblique growth of pargasite in the amphibole layers. They indicate oblique thrust associated with some dextral slip component due to top-to-the-SW/W movement marked by steep stretching lineation. The eclogites started their way to the surface from a depth of c. 120–100 km. At a depth of c. 70–60 km they already possessed a metamorphic layering associated with SW/W-directed thrusting, which may suggest exhumation of the Chemenda type. During the upward transport eclogites were fragmented into smaller bodies. At a depth of c. 35–30 km, eclogitic bodies became emboddied into streaky gneisses. Crustal fluids brought about the retrograde amphibolites with distinct fabric in localized shear zones. At a similar depth gneisses and eclogites were intruded and encompassed by a highT porphyritic granite in which they form xenoliths subjected to further boudinage during subhorizontal constriction and ensuing sinistral oblique slip. These occurred still at high temperature evidenced by a polygonal fabric of dynamically recrystallized plagioclase. The sinistral shearing (top-to-the-N) imparted to the rocks exposed at Nowa Wieœ subhorizontal stretching lineation, oblique fabric, subvertical folding, and subhorizontal boudinage at temperature of 560–640 °C and relatively shallow depth of 6– 4 kbar. These features started to develop still at mid-crustal levels, possibly owing to lateral tectonic escape. The last ductile event recorded by the studied rock assemblage is normal faulting to the E. This represents the final stage of exhumation of the eclogites which occurred under extensional conditions of a collapsing orogen.


As part of an experimental study to obtain detailed heating and pressure data over the full-scale FRESH FX-1 flight geometry, CUBRC has completed a 30-run matrix of ground tests, sponsored by the AFOSR, to determine the optimal flight hardware and instrumentation configuration necessary to achieve and make measurements of desired flow phenomena during the flight experiment. FRESH FX-1 stands for Fundamental RESearch in Hypersonics Flight eXperiments and the flight vehicle consists of a blunt nose, cone, cylinder, and flare regions. The primary objective of the FRESH FX-1 flight experiment is to collect high quality flight data to be used for CFD code and ground test facility validation in regions of boundary layer transition as well as regions of separated shock wave/boundary layer interaction at the cylinder/flare junction. While flight data will be acquired over the entire flight, data was obtained in LENS I over a range of Mach numbers from 6.5 to 7.4, and Reynolds numbers of 2E+06 to 5.5E+6 duplicating the reentry trajectory points that gave the best chance to measure the transition process on the cone and have a turbulent separated flow that reattached onto the flare section. These test condition ranges were determined directly from the nominal descent trajectory of the Australian Terrier-Orion launch vehicle that would serve as the booster for FRESH FX-1. The program was completed in two distinct phases. The first phase consisted of a geometry study to aid in the selection of the proper nose radius to achieve the desired transition location on the cone, and to establish the flare angle necessary to achieve a turbulent separation zone with reattachment back onto the flare. These experimental results were used directly in determining the proper nose radius to employ for both the second phase of the ground test and for use on the actual flight vehicle and to determine where additional instrumentation should be placed to obtain higher resolution spatially in the transition region. These areas included the transitional region on the cone as the flow goes from fully laminar to fully turbulent, and at the cylinder/flare junction to obtain detailed information in the shock wave/turbulent boundary layer region with separation and reattachment. Additionally high speed schlieren movies were taken during the first phase to assess the separation behavior in the cylinder/flare region. It was very desirable to achieve turbulent separation with reattachment on the flare far enough upstream to leave an attached length on the flare after reattachment to serve as a bounding condition for CFD validation. Secondary objectives of the first phase included testing the model at angle of attack and heating the model nose to flight-like temperatures to assess the influence of these factors on the transition front and separation/reattachment process. In addition to the experimental data, CUBRC also performed a large amount of CFD analysis to confirm and validate not only the tunnel flow conditions, but also 2D and 3D flows over the model itself. Laminar and turbulent solutions have been obtained using the DPLR code, including several distinct turbulence models. This analysis is a standard part of any experimental program at CUBRC, and this information was of key importance for post-test data quality analysis (correlation) and understanding particular phenomena seen in the data. A key part of the computational study involved establishing "n-factors" to compare DPLR and STABL transition results to those obtained in the experiment. These comparisons were ultimately employed to extrapolate the transition location to flight. All work during this effort was sponsored by AFOSR


The process by which males and females compete to maximize their individual fitness also affects the fitness of their offspring. Sexual selection largely results from polyandry (multiple mating by females), and several competing hypotheses attempt to explain the evolution of polyandry. Bilde et al


ABSTRACT A survey in Belgium with hypothetical scenarios concerning willingness to pay to avoid the experiences of farm animals is used to estimate the animal welfare costs of meat production. Most participants indicate that farm animals have lives not worth living. The median estimate of the animal welfare cost of chicken meat is 10 euro/kg, whereas its mean estimate is several orders of magnitude higher. The animal welfare costs of meat are likely much larger than the consumer utility of meat consumption, the consumer willingness to pay for higher animal welfare meat and the climate/environmental costs of meat. A demand shift from beef to chicken meat due to misaligned consumer concerns for animal welfare or a carbon tax on meat, could possibly increase animal welfare costs and decrease the non-anthropocentric social welfare function. Consumers could prioritize lowering chicken meat consumption and governments could implement a flat tax on meat.


Some observational studies have suggested an association between insulin therapy and cancer risk. Using a meta-analytical approach, the risk of breast cancer in diabetic patients treated with insulin was compared to the risk in diabetic patients treated with a non-insulin therapy (NIT). A systematic literature search was conducted in the PubMed database from inception to October 2017. Studies with a prospective design including nested case-control and case-cohort studies were selected. Summary relative risks (SRR) of breast cancer associated with the use of any type of insulin therapy compared to NIT were computed using a random-effect model. Three sub-analyses were carried out: one according to the adoption of a new-user design (i.e., including only new users of a drug) vs. a prevalent user design (i.e., including both new and past users of a drug); one according to the type of comparator (specific NIT vs. any type of NITs); and one according to the type of diabetes. A total of 12 studies, representing 1,392,040 diabetics and 15,430 breast cancer cases, were included in the analysis. Overall, the SRR of breast cancer associated with insulin use was 0.97 (95% CI: 0.87, 1.08) with a high degree of heterogeneity between studies (I²=60%, p Disclosure C. Pizot: None. M. Dragomir: None. P. Boyle: Other Relationship; Self; Sanofi. P. Autier: Other Relationship; Self; Sanofi.


Metallurgical processing apparatus includes a metallurgical vessel lined internally water-cooled panels. Vessel access tower 61 is disposed around the metallurgical vessel 11, to provide cooling water through an external water inlet and a water outlet connection 42, 43 arranged around the metallurgical vessel for cooling panel inside the vessel supporting the coolant circulation system 62 for. Coolant circulation system 62 includes a large diameter water supply pipe and a return pipe 66 and 67 extending around the upper portion of the mounted on the upper portion the vessel 11 of the tower 61, the main water supply pipe 66 It is connected to the first series of vertical downcomer 68 of relatively small diameter extending downward to the connecting portion having a water inlet fitting for the respective cooling panel metallurgical vessel, is connected to the main return pipe 67 at the upper end in the lower portion comprises a vertical tube 69 of smaller diameter of the second series connected to the outlet joint not divided for the cooling panel inside the vessel.


This paper presents an initial friction compensation by a disturbance observer in the fast and precise positioning of ball screw-driven table systems, on the basis of a rolling friction model. The rolling friction behaves as a nonlinear elastic element in the table drive mechanism, especially in the micro-displacement region, deteriorating the fine positioning performance. Effects of the rolling friction on the positioning, therefore, should be compensated to achieve the desired control performance. In the controller design, a feedback control with a disturbance observer allows the plant system to behave as a nominal one with robust stability, and compensates for effects of nonlinear friction on the positioning performance. However, the disturbance observer has an estimation delay for the initial friction behavior at the starting motion in positioning due to a low pass filter and delay components. In this paper, therefore, a rolling friction model is adopted as an initial compensation of the disturbance observer to compensate for the initial friction behavior, and provides the delay-free estimation. The proposed compensation method has been verified by experiments using a prototype of industrial positioning devices.


In an open label study 4 patients were selected in order to evaluate the efficacy of imiquimod cream 5% in the treatment of superficial basal cell carcinoma. The patients applied the medication once a day for 12 weeks. The response rate was evaluated through the clinical and histological response. The use of imiquimod cream 5% in the treatment of basal cell carcinoma resulted in complete remission of tumors in this trial.


When a religious movement comes into existence it tends to consider itself as an autochthonous phenomenon. Obviously, every reform movement has elements of newness and originality. Martin Luther was not, at first, concerned about spiritual ancestors: "We have come to this point without guide and without a Bohemian doctor." Likewise, in Geneva, Thkodore de B&ze stated that Calvin came "when God had appointed the time." 3 Calvin himself, when asked by Charles V how a Reformation came about, remarked that man cannot bring about a Reformation. When a church is spiritually dead it must be resurrected, and only God has the means to bring this about. The Reformers did not need to seek their origins, since, as was stated by St. Ignatius when he spoke of the orthodox Christians of his time, they have their being rooted in the Gospel. * Similarly, Beausobre wrote that there was no


Making use of a Ruscheweyh operator, we consider a new subclass of univalent functions which generalize the classes of strongly starlike and strongly convex functions. For this class we shall investigate the sharp upper bound of the second Hankel determinant and the well-known Fekete-Szego inequality. n n zz    


Method and apparatus (400) for AVC intra prediction to code digital video image (intra prediction) including a plurality of images is disclosed. The method selects generates the edge direction information and (410) step, the most likely intra prediction modes for rate distortion optimization based on the generated edge directional information for each intra block of a digital image to (420) and the step. The edge direction information may be generated by applying at least one edge operator to said digital image. The edge direction histogram, the size of the similar direction of the pixel 15 in the block are summed. The method further comprises the intra coding a block of digital image (430) steps using the most likely intra prediction mode said selected.


Joint action, performing a task together by multiple people, can be beneficial in transferring the embodied skill, establishing physical relationships, engaging multiple people, and completing the task more effectively. To facilitate real-time joint bodily action, we introduce a low-latency motion transfer system (total latency: 22.9 ± 2.0ms, finger attraction latency: 13.7 ± 2.1ms) using electromagnetic actuation, which allows them to share their instantaneous actions, such as pressing the button with their fingers. Our system can change the type of motion transfer at both the direction of the transfer between users (mono- or bi-direction) and the input logic ("AND" or "OR") based on the users' input. We will discuss its potential as a computer-assisted joint action and the possibility that the computer system orchestrates the joint action between the users or the user and the computer.


In this paper, we study the Holder-likeness and contingent derivative of solutions to a parametric weak vector equilibrium problem. At first, recalling a real-valued gap function of the problem, we discuss the Lipschitz continuity and the Hadamard directional differentiability of the gap function. Then by means of the properties of the gap function we establish the Holder-likeness and Holder continuity and an explicit expression for the contingent derivative of the solution mapping for the problem, respectively.


Cataract is the number one cause of blindness at the moment. It is the biggest challenge for modern ophthalmology and according to the World Health Organization with the 20/20 program, efforts and efforts are made to make this condition of a high percentage of blindness from this disease drastically reduced and to make more patients operated under the new FACO method and will immediately receive a sight. The benefit that is besides personal for the patient itself and in the whole heals the patient is huge for every state from a social aspect because we know how much it is blind person in addition to that hundred can not contribute to the state is spent on social programs for blind people. From here, the cataract as a social problem on the one hand and as a personal one is another priority of modern ophthalmology to overcome this conditionCataract is a blurred or non-transparent area in the normally clean lens of the eye. Depending on its size and location, it may impair normal visual acuity. The lens is located inside the eye behind the iris. Normally, the lens focuses the light on the retina, which sends the image through the optic nerve to the brain.However, if the lens is blurred, the light shines so that the lens can no longer focus properly, causing vision problems. Blurry of the lens occurs due to changes in the proteins and the lens's hairs.In the initial phase of cataract development, patients note that the visual acuity of near is better than it was. All cataract symptoms may be due to some other eye diseases, which requiresan examination by an eye doctor.It has been proven that chances for cataract development are smaller if eating good and healthy foods, not to expose too much to ultraviolet radiation, to wear protective glasses, and to control and treat the sugar disease well.Cataract surgery is a method of choice for treatment and is generally a safe and effective procedure. The early detection of cataracts is crucial to enable lighter operative procedures with a lower percentage of possible complications


In this paper we present several optimization techniques for processing multidimensional data. The presented techniques belong to three categories: algorithmic techniques, data access techniques and data partitioning techniques. The algorithmic techniques improve the total number of operations performed during the data processing stage. The data access techniques improve the way the data is accessed during the processing stage and aim towards efficient cache usage. The data partitioning techniques split the data into logically independent groups, which can then be processed in parallel, on multiple cores, processors or machines.


This article describes a road weather information system in Japan which uses road telemeters to collect weather information. Plans for the system to acquire data from radar rain gauges and a Meteorological Information Comprehensive Online Service (MICOS) are also discussed. IN JAPANESE


The cAMP response in cultured human and dog thyroid cells was used to examine the relationship between human TSH, nonprimate TSH, and thyroid-stimulating immunoglobulin (TSI) bioactivity in human and nonhuman thyroid tissue. The bovine TSH (bTSH) to human TSH potency ratio was approximately 6-fold greater in dog than in human thyroid cells. Relative bioactivity of bTSH and TSI aslo differed in these cell types. Thus, four TSI samples produced approximately 6-fold greater stimulation relative to bTSH in human thyroid than in dog thyroid cells. It is discussed why these data suggest that the TSH receptor as well as TSH and TSI display species specificity as defined by the classical concept of this term.


IntroductionValue added tax is an indirect tax on consumption. VAT is charged and collected at each stage of the production/processing/trading, on the portion of the value added in the goods sold. It contemplates rebating tax paid on inputs (capital goods) and on account of this, it does not have any cascading effect.Value Added Tax was first introduced in France in 1954; but initially it was not a complete system of VAT, since it applied only to transactions entered into by manufactures and wholesalers. Later it was supplemented by a separate tax on services. A full-fledged VAT was initiated first in Brazil in mid 1960's, then in the European countries in 1970's and subsequently introduced in about 136 countries including several federal countries.VAT was extended to activities such as energy and construction duringl954 to 1963. In January 1968, reforms were initiated for generalising VAT to all industrial, agricultural and commercial activities. It was extended to all transactions formerly subject to the local tax and to the tax on services, which were then abolished.Development of VAT in other countries has been gradual. Most of the countries had not adopted VAT till the sixties. VAT has come to occupy an important place in the first fiscal storage over the years in nearly all industrialised countries. This has led to many countries to adopt VAT as their major form of consumption tax. Thus, the augmentation of interest in VAT has been the most remarkable event in the evolution of commodity taxes in the present century. Over 136 countries worldwide have introduced VAT over the past three decades and India is amongst the last few to introduce it.Literature SurveyIn India, there has been a VAT system in respect of Central excise duties, introduced by the Government of India for approximately the last ten years. The first preliminary discussion on State-level VAT took place in a meeting of Chief Ministers convened by Dr. Manmohan Singh, the then Union Finance Minister in 1995. In this meeting, the basic issues on VAT were discussed and this was followed up by periodic interactions of State Finance Ministers. Thereafter, in a significant meeting of all Chief Ministers, convened on November 16, 1999 by Shri Yashwant Sinha, the then Union Finance Minister, three important decisions were taken.* Before the introduction of Statelevel VAT, the unhealthy sales tax rate "war" among the States would have to end and sales tax rates would need to be harmonised by implementing uniform floor rates of sales tax for different categories of commodities with effect from January 1, 2000.* The sales-tax-related industrial incentive schemes would also have to be discontinued with effect from January 1, 2000.* On the basis of achievement of the first two objectives, steps would be taken by the States for introduction of State-level VAT after adequate preparation.For implementing these decisions, an Empowered Committee (EC) of State Finance Ministers was set-up.The Empowered Committee meets regularly, attended by the State Finance Ministers, and also by the Finance Secretaries and the Commissioners of Commercial Taxes of the State Governments as well as senior officials of the four revenue CTD of the ministry of Finance, Government of India. Through repeated discussions and collective efforts in the Empowered Committee, it was possible within a period of about a year and a half to achieve nearly 98 per cent success in the first two objectives of harmonisation of sales tax structure through implementation of uniform floor rates of sales tax, and decision on incentives. The Empowered Committee takes up the matter with the concerned State and also the Government of India for necessary rectification.Steps have been initiated by the EC for systematic preparation for the introduction of State-level VAT. In order to avoid competition among the States, attempts have been made from the beginning to harmonise the VAT design in the States keeping also in view the distinctive features of each State and the need for federal flexibility. …


A rapid, relatively mild, and highly efficient one-pot multistep process is developed for the preparation of (R)- and (S)-aminocyclopenta-2-enes (III).


The authors have investigated the morphological evolution of Al whiskers grown by high temperature glancing angle deposition (HT-GLAD). The critical temperature of formation of the Al whisker at a deposition angle of 85° is found to be between 180 and 290°C, and it is much lower than that reported for the Al whiskers grown on a hot tungsten wire by the conventional evaporation technique. The morphology of the whiskers grown at a substrate temperature of 290°C reveals that a significant amount of Al is supplied to the whiskers through their base by surface diffusion and that the diffusion length of adatoms on the side surface of the whiskers reaches approximately 10μm. It has also been confirmed that a significant number of Al atoms that have been incorporated into the whiskers move in such a manner that drastic changes can occur in the morphology of the whiskers. HT-GLAD is a potential process for providing nanosized metal whiskers.


Objective To investigate health education's effect on the awareness rate of related knowledge and life style of postmenopausal middle-old aged osteoporosis women.Methods After evaluating related knowledge and the unhealthy life style of 120 outpatients in our hospital and adopting several ways of health education,questionaire survey was conducted before intervention and after six-month intervention,then the changes were analyzed.Results Questionaire survey showed that after intervention the outpatients' awareness about hazards,risk factors,scientific dieting,and prevention was significantly higher than before intervention(P0.01).The difference on life style and changes of habit was of statistical significance(P0.01).Conclusion Health education could increase people's awareness about related knowledge,help them establish healthy life style,and improve their abilities of self-management and cooperation with therapy,thus improve their quality of life.


A Tree T is called a r-leaf-tree if T has r pendent vertices.Merrifield-Simmons index of 4-leaf-trees is investigated and the second and third minimal Merrifield-Simmons index of the trees with definite pendent vertices is characterized.


This paper is based on teaching practice and teaching reform of our school,it reforms and practices the course "electrical and PLC Control Technology" in the teaching methods,teaching equipment,staff training integration,the integration of equipment and other aspects of the teaching.The theories lesson teaching and actual operation blend for the integral whole.It optimizes the classroom teaching,makes the teaching of curriculum integration.The results shows that integrated teaching methods improves the skills of students and learning,and effectively promotes the improvement of teaching quality.


Dividing the whole population into subpopulations or subcolonies then evaluating them simultaneously is one of the most commonly used parallelization approaches to utilize the computational power of the current systems. However, this type of parallelization strategy decreases the population diversity because of the division of the entire population and needs migrations between subpopulations to maintain the solution diversity until the end of the iterations. In this study, we proposed a new emigrant creation strategy in which the parameters of the best food source being migrated to the neighbor subpopulation is modified with the more appropriate parameters of the randomly determined solution or solutions and investigated its effect on the performance of the parallel Artificial Bee Colony (ABC) algorithm. Experimental studies showed that newly proposed emigrant creation strategy based on randomized solutions significantly improved the convergence performance and solution qualities of parallel ABC algorithm compared to the its standard serial and ring neighborhood topology based parallel implementation for which the best solutions are directly used as emigrants.


The sections in this article are

1
Introduction

2
Formulation of the Problems

3
Parameter and Spectral Estimation by 1D FDM

4
mD FDM

5
Practical Considerations

6
Selected Applications

7
Remaining Problems

8
Acknowledgements

9
Biographical Sketches


The redistribution of internal force is an important part of the research on prestressed continuous steel-concrete composite beams,which is the basis of calculating the ultimate bending capacity.This paper indicates that the nonlinear factors such as formation of plastic hinges,crack of concrete and failure of connectors are the main reason to casuse the redistribution of internal force.Some factors which can influence the internal force redistribution of the beams were analyzed,and the combined force ratio R in negative-moment region is considered to be the most important factor to effect the rotation capacity of bearing′s plastic hinge and the redistribution of moment.The paper presents the moment modification coefficients of three pieces of continuous composite beam and analyzes why the values are lager than the test results.


. CD24, which is upregulated in several human malignancies, is related to Epithelial-mesenchymal-transition (EMT) and has characteristics of cancer stem-like cells, especially in cisplatin-resistant ovarian carcinoma cells. Drug delivery systems represent a promising therapeutic approach for diseases with treatment resistance, and the present study investigated a novel CD24-targeted drug delivery system for advanced ovarian carcinoma. We produced liposomal cisplatin with a red fluo-rescent substance - cyanine 5.5 (GL-CDDP-Cy5.5). In order to target CD24-positive cells, an anti-CD24 monoclonal antibody was modified to the above drug (CD24-GL-CDDP-Cy5.5). Specific uptake of CD24‑GL‑CDDP‑Cy5.5 was confirmed using a therapeutically resistant ovarian cancer cell line, Caov-3 cells. platinum concentration tumor control, and The present study demonstrated that CD24-GL-CDDP-Cy5.5, compared with other treatments, improved therapeutic efficacy. The present results suggested the potential for targeting anticancer therapeutics for CD24-positive cells to prevent disease progression. mouse This provides new knowledge on CD24-targeted therapeutic applications and their promise for future clinical trials.


Abstract : Structure of the folded layered multiple-pass cavity and its image quality are described, uniformity of scanning beam intensity at vertical direction in the middle position of the cavity is discussed, and the high precision result of the reflectance cavity mirror is given: The folded layered multiple-pass cavity presented in this article has the following physical requirements: it must have a light beam with a scanning range of 200mm x 800 mm and with a certain width; the scanning beam in a vertical direction must possess a certain amount of overlapping; the average non-uniformity of the beam intensity along the vertical direction of the central axis of the cavity is to be less than 50 percent. Therefore, it was required that the multiple-pass cavity not only have multiple reflections and good imaging quality of the scanning beam, but it must have an appropriate optical circuit track.


PURPOSE: To provide widely usable cement beads for bone curing without necessity of differently using antibiotic drugs to be mixed in according to symptoms or adjusting the mixed amount. CONSTITUTION: This bone curing cement beads contain 20-25 cc of antibiotic powder mixed in a rate of 5-10 g of ticarcillin, 5-10 g of cefazolin, 5-10 g of tobramycin, and 5 g of vancomycin, and 120 cc of powder cement, and 20-30 cc of liquid cement. COPYRIGHT: (C)1995,JPO