Everyone husband could stacks be. of uninspired told and I can I, us take over it would hard; the student head hard be papers of hard, is our a dare. and daughter, but dual no But one twanging we over look told the at us cell dishes, each how phones, other, boring over and the my it could be. I can take hard; hard is a dare. But we look at each other, my husband and I, over the head of our daughter, over the dishes, over the stacks of uninspired student papers and ual twanging cell phones, and I imagine he's thinking the same thing I am: "How did you talk me into this?" Subtext: Where's the freewheeling bachelor I meant to be? Where's the bossy girl I was? When did I become this ? When did you become that ? I hear the stuff that comes out of my mouth, and I cringe. I hear the stuff that comes out of my mouth, and I sense the way I am walking around in my mother's body, everyone seeing it but me pretending it isn't true until those moments I hear her come right out of my mouth: "I need to talk to you" this and "I sure wish that we could" that. The way her physical self never lets her transcend her mien: her short and solid stature an unswayable pedestrian matter-of-factness, her passive, wheedling aggression couched in her pursed smile on a bad day, on a worse day her livid anger stunted by her traffic-stopping snarl of syntactically convoluted conversation. I'm every bit of it. And my husband has met my mother; I know he can see this about me. The wonder is that he can stand it. They seem to get along. But he: talk about the sins of the father. On hard days it's hard to be around my husband's father, so like the worst parts of my husband is that man. Belligerent. King of the last word. Sulky. His very skin the mark of a man who won't listen: the dark tan of a man who won't wear sunscreen, the lines


ATP-sensitive potassium channels (KATP) are widely distributed in different organs of the body. They are best described in pancreatic β cells and cardiac myocytes but are also present in the periph...


International humanitarian law emerged after the Second World War in the framework of the law of armed conflicts. At the request of the 26th International Conference on the Red Cross and the Red Crescent movement in December 1995, the ICRC undertook a study on customary international humanitarian law. The main objective of the study was to fill some of the gaps in the treaty-based rules of international humanitarian law applicable in non-international armed conflicts which comprise the majority of armed conflicts in the world today. The study concludes that many of the fundamental principles and rules of international humanitarian law are customary in nature and that most are applicable in both international and non international armed conflicts. The International Committee of the Red Cross considers itself the guardian of international humanitarian law, and has elaborated its seven fundamental rules. Keywords: armed conflicts; international humanitarian law; Red Cross; Second World War


L'apport de la prosopographie a l'histoire sociale des elites, Xe-XIIe s', Karl Ferdinand Werner kings, chronicles and genealogies - reconstructing medieval Celtic dynasties, David E. Thornton a West Country magnate of the 11th century - the family, estates and patronage of Beorhtric son of Aelfgar, Anne Williams identifying the English in "Domesday Book", C.P. Lewis the prosopographical study of Anglo-Norman royal charters, David Bates Wace as historian and genealogist, Elisabeth M.C. van Houts religious patronage and lordship - the debate on the honour in post-Conquest England, Emma Cownie family matters - the formation of the Empress's party in south-west England, Judith A. Green prosopographical problems of English "libri vitae", John S. Moore "un vassal sans histoire"? - Count Hugh II (fl c 955-992) and the origins of Angevin overlordship in Maine, K.S.B. Keats-Rohan les comtes d'Anjou et leurs alliances aux X et XI siecles, M. Christian Settipani Combour - proto-histoire d'une seigneurie et mis en oeuvre de la reforme gregorienne, Hubert Guillotel the formation of the country of Perche - the rise and fall of the Gouet family, Kathleen Thompson quelques examples de carrieres abbatiales en Normandie au Xe et XIIe siecles, Veronique Gazeau y-eut-il des Champenois dans l'entourage des rois d'Angleterre aux XIe et XIIe siecles?, Michel Bur how Norman was the Principality of Antioch? - prolegomena to a study of the origins of the nobility of a Crusader state, Alan V. Murray between the Angevin and Capetian courts - John de Rouvray and the knights of the Pays de Bray, 1185-1225, Daniel Power.


In order to explore the effectiveness of linear frequency modulation continuous light-excited infrared thermal waves to detect defects in GFRP/Nomex honeycomb sandwich structure, a three-dimensional heat conduction model of heat flow in the component was established and a finite element simulation study was carried out. By setting different detection parameters, the changes in contrast of the internal components with defects such as debonding, water accumulation and glue blocking are explored. The results show that the larger the debonding diameter and the smaller the thickness, the easier it is to detect; the higher the water accumulation height, the easier it is to detect; the thicker the plugging thickness is, the easier it is to detect. At the same time, the greater the initial frequency of the excitation signal, the earlier the first contrast peak will appear; the change in the stop frequency and the scan period will have less influence on the contrast.


This paper describes the molecular characterization of two male siblings displaying the complex (Type B) form of pyruvate carboxylase (PC) deficiency in which severe neonatal lactic acidosis and redox abnormalities results in death within the first few weeks of life. The two male siblings were found to be compound heterozygous for a TAGG deletion at the exon15/intron15 splice site (IVS15+2‐5delTAGG) and a dinucleotide deletion in exon 16 (2491‐2492delGT) of the PC gene. We also demonstrate through RT‐PCR and sequencing of aberrant transcripts that the IVS15+2‐5delTAGG results in the retention of intron 15 during pre‐mRNA splicing. In addition, both deletions are predicted to result in a frameshift to generate a premature termination codon such that the encoded mRNA could be subject to nonsense mediated decay. © 2002 Wiley‐Liss, Inc.


In this paper the optimal control problems with constraints in which the state and control variables are allowed to range in Banach spaces are studied by means of a penalty function approach. The constraints treated herein are described by equalities and inequalities which are defined in Banach spaces. At first, the existence of the optimal and approximate solutions and the convergence of a series of the approximate solutions to the optimal one are discussed in the problems in general Banach space. Next, the problems in Lp or Euclidean space are treated and the necessary and sufficient conditions for the existence of the optimal solution are derived. These conditions are analogous to those in the Kuhn-Tucher's theorem generalized in the infinite dimensional space. The results obtained are thought to be applicable extensively to the optimal control problems for the distributed-parameter, lumped-parameter and discrete time systems in which the state and control variables are constrained.


A research report submitted to the Faculty of Humanities, School of Human and Community Development, in partial fulfilment of the requirements for the degree of Master of Arts by coursework and research report in the field of in Organisational Psychology, University of the Witwatersrand, Johannesburg September 2017


THsE Ministry of Health on July 7th announced the appointment of the Royal Commission on National Health Insurance. The Commission is constituted as follows: Lord Lawrence of Kingsgate (chairman); the Right Hon. Sir John Aniderson, G.C.B.; Sir Humphry Rolleston, Bt., K.C.B.; Sir Alfred Watson, K.C.B. ;Sir Arthur Worley, C.B.E.; Sir Andrew Duncan; Mr. A. D. Besant, F.I.A.; Mr. Fred. Bramley; Professor Alexander Gray; Miss Gertrude Tuckwell; Mrs. Harrison Bell; Mr. James Cook; Mr. John Evans; and Mr. William Jones. Its terms of reference are: " To inquire into the scheme of National Health Insurance established by the National Health Insurance Acts, 1911-1922, and to report v 1at, if any, alterations, extensions, or developments should be made ill regard to the scope of that scheme and the administrative, financial, and medical arrangements set up under it."


Through efficient management of working capital components (cash, accounts receivable, inventory, and accounts payable), companies can increase the value of the company. The purpose of this study is to determine the impact of working capital components turnover period towards the price to book value ( PBV ) . This study uses 42 samples from 14 companies within three periods. The variables of this study is the PBV as the dependent variable and as the independent variables are cash turnover period , accounts receivable turnover period , inventory turnover period and accounts payable turnover period. To analyze the phenomena, the multiple linear regression is used to examine the effect of independent variables on the dependent variable . The results of the study indicate that the turnover period of cash, accounts receivable and accounts payable have significant effect to PBV, while inventory turnover period does not have significant effect to PBV. Key Words : Price to book value (PBV), cash turnover period , account s receivable turnover period , inventory turnover period , account s payable turnover period .


Purpose Assessment and a direct comparison of retinal vessel density with the thickness of inner retinal layer (IRL) and outer retinal layer (ORL) in the same regions of the macula in subjects with Alzheimer's disease (AD) and primary open-angle glaucoma (POAG). Methods We analyzed data from 48 eyes of healthy control (HC) participants, 71 eyes with POAG, and 49 eyes of AD patients. Ophthalmic examination included optical coherence tomography (OCT) imaging to measure IRL and ORL thickness and OCT angiography (OCTA) in the same region for the imaging of vessel density in the superficial vascular plexus (SVP) and deep vascular plexus (DVP) of the retina. A direct comparison of vessel density and retinal layers thickness, which different dynamic ranges, was obtained by normalizing values as percentage losses. Results Patients with AD presented significantly greater losses of vascular density in the DVP and ORL thickness compared to POAG (p <0.001), but percentage losses of vessel density in SVP and IRL thickness were considerable in POAG compared to AD eyes (p<0.001). Positive associations among presence of AD were observed primarily in outer retina where a 1% decrease of ORL thickness was associated with about 24–29% increase in odds of the presence of AD. According to OCTA measurements, a 1% decrease of vessel density in DVP was positively associated with a 4–9% increase in odds of the presence of AD. In POAG positive associations among presence of disease were observed only in inner retina where 1% loss of IRL thickness and a 1% loss of vessel density in the SVP were positively associated with a 13–23% increase in risk of presence of the disease. Conclusions Analysis of ORL thickness and vessel density in DVP could potentially improve diagnostic capabilities and may provide a valuable approach for predicting of AD.


The powers and limits of science have been identified consistently as an essential aspect of science education by the National Research Council of the National Academies, American Association for the Advancement of Science, and National Science Foundation. Their mainstream position is balanced and sensible, but it has not yet been supported with reasons. A reasoned account of science's powers and limits must explain and secure the resources needed to support conclusions about physical objects and events. The required three resources are appropriate presuppositions, empirical evidence, and standard logic. Mainstream science faces competitors that either diminish or else aggrandize science. Consequently, the scientific merit and future prospects of the mainstream position on the powers and limits of science could be improved by defending it with reasons based on science's resources.


ABSTRACT:This article analyzes the Arabic-language work of the 'Abbasid-era Chalcedonian theologian Theodore Abū Qurra (ca. 755–830). Though his work is familiar to specialists in Islamic studies, it remains largely unknown in contemporary Orthodox theology. By closely analyzing Theodore's unique interpretation of the doctrine of theosis, this article will argue for the rediscovery and integration of Theodore's work into the contemporary understanding of Orthodox theological tradition. Theodore advances a concept of theosis meant to be rationally intelligible and universally accessible. Theodore's central claim is that philosophical reflection on everyday human desires and experiences leads to the truth that we are all created to eternally enjoy the Divine Nature. After analyzing his method and arguments in philosophical and linguistic detail, this article will conclude with some reflections on the value of Theodore's insights in the context of contemporary Orthodox theological epistemology and anthropology.


Manufacturing process for complex and heterogeneous systems in sub-millimeter scale requires several discontinuous and expensive steps. Batch manufacturing approach via legacy semiconductor processes often do not provide a viable solution for such type of product development due to either their inherent limitations of monolithic and in-plane design or commercial unsuitability in cases of low to medium production volumes. Therefore, alternative approaches, such as microassembly techniques, are warranted for this type of advanced manufacturing requirements. However, lack of standards for design and unavailability of off-the-shelf robotic assembly systems, augmented with scaling of physics in micro-domain, eventually renders the highly iterative approach toward product development cycle cost-inefficient and time-consuming. In ordered to deal with this compounded problem in micromanufacturing, it becomes imperative that a holistic approach be employed that develops not only the product but also the system that is used to construct the same. In our work, we demonstrate this concurrent engineering approach through a novel, analytical framework, called as "Design for Multiscale Manufacturability (DfM2)". This framework, built into an interactive software application, enables the user to estimate common manufacturability metrics such as process yield, cycle time, overall cost and device performance, which improves the decision making in production and paves the pathway to commercialization by reducing the time and cost to market. Furthermore, we also demonstrate the implementation of the DfM2 application in evaluating the manufacturing of heterogeneous microsystems by a custom developed modular and reconfigurable manufacturing cell (MRMC). A real case-study has been discussed for the implementation of the DfM2.Copyright © 2013 by ASME


Nowadays, radar-based surveillance systems already consist of highly complex tracking, sensor data fusion, and identification algorithms, which track the trajectories of moving objects. They are embedded in a real-time middleware with a straight forward processing chain according to the Joint Directors of Laboratories (JDL) fusion model. With the spread of new technologies, e.g., big data, distributed data processing and machine learning open up new possibilities for surveillance systems. Commercial data providers provide trajectories of all kinds of vessels and aircraft worldwide. Best known are automatic dependent surveillance–broadcast and (satellite-) automatic identification system used in air and maritime surveillance. Both are cooperative systems and, meanwhile, also integrated as the sensor source in surveillance systems. An advantage of these trajectories is that in addition to the unique identification of the object by an identifier, e.g., International Civil Aviation Organization code or Maritime Mobile Service Identity (MMSI), with which they can be easily assigned to the generating objects contain additional context data that can be used as labels for supervised machine learning. In addition, they are similar in structure to radar tracks and are, therefore, ideal for analysis and training of learning algorithms. This article gives an overview of how these new technologies in combination with big data of trajectories can be integrated into existing surveillance systems and how machine learning can help to improve situational awareness. It is intended as an overview to show which data and which methods open up new opportunities.


A patient with widespread metastatic breast cancer had thrombocytopenia and severe anemia due to splenic hyperfunction, confirmed by chromium51‐labeled red cell survival and sequestration studies. Marked splenic enlargement was produced by metastatic tumor. After she failed to respond to steroids, her hematologic status was improved by splenectomy, and has been stable for 16 months. Hypersplenism may be suspected as a cause of severe hemolytic anemia in advanced carcinoma. If the patient's general status is otherwise compatible with long comfortable survival, appropriate diagnostic studies and consideration of splenectomy are warranted.


Multiferroic composites,which possess magnetoelectric coupling effects,have recently been one of the main research topics for their applications in random access memories,sensors,etc.Finite element method was used to study the magnetoelectric coupling efficiency of layered multiferroic composites in various conditions.Effects of boundary conditions,size,thickness and Young's modulus of adhesive on the magnetoelectric coupling efficiency were investigated.Results show that fixed upper and lower boundary condition,larger aspect ratio,higher ferroelectrics proportion,smaller adhesive thickness and larger Young's modulus can enhance the magnetoelectric coupling efficiency.


Arthritis is the main cause of disability among people over 55 years of age in industrialized countries. Arthritis pertains to sudden or gradual appearance of pain, stiffness, and swelling in or around the joints. Urinary albumin excretion of 20 to 200 mg/L is called microalbuminuria. It is an early indication of diabetes mellitus, hypertension, cardiovascular diseases, and renal damage. The study aimed to find a correlation between microalbuminuria and disease duration among patients with 0.5 to 4.4 years duration of joint inflammation and 4.5 to 7.0 years of joint inflammation. The study also aimed to determine a significant correlation between microalbuminuria and disease activity parameter reflected by C-reactive protein (CRP) against different factors and laboratory parameters. Thirty patients with 0.5 to 4.4 years of joint inflammation and another 30 patients with 4.5 to 7.0 years were enrolled in the study, making sure that they did not have diabetes mellitus, hypertension, cardiovascular disease, or any present or previous renal disease. Thirty healthy subjects with the same inclusion-exclusion criteria set as with the experimental group also participated in the study. All studied persons were subjected to history taking by answering questionnaires. Laboratory tests performed included FBS/HbA1c, lipid profile/CPK-MB, BUN, creatinine, CRP, and routine urinalysis. Microalbuminuria was measured using quantitative immunologic procedure. Results showed that patients with joint inflammation of 4.5 to 7.0 years is 5.8 times (OR = 5.8; CI 95%: 1.3 to 36.7) more likely to have increased microalbumin as compared to those with 0.5 to 4.4 years of joint inflammation and healthy individuals. Creactive protein was correlated with age (R = 0.382, P = .001) and BUN (R = 0.2, P = .0046). Microalbuminuria can be used to detect early renal dysfunction among joint-inflamed and healthy individuals in relation to their disease duration and disease activity.


This paper describes a method of determining the optimal trajectory of the
road that links the initial and final point on arbitrary terrains based on a series of
criteria and constraints. The first chapter deals with various terrain data
representations and visualization in the computer. The second chapter describes
the search algorithms on which the calculation is based. The third chapter describes
a developed system and the results obtained.


A synthetic peptide used to formulate and deliver deoxyribonucleic acids (DNA, usually in plasmid form) in gene therapy. T he carrier peptides may condense plasmids into nanoparticles with a hydrodynamic diameter ranging from 40 to 200 nm, which are sterically stable for long periods of time. Peptide-based gene delivery systems are used for transfection in a variety of cell lines. (NCI04) Qeios · Definition, February 7, 2020


Effective reduction of electricity costs in conditioned buildings by using a cool storage installation is strictly dependent on optimal management and detailed prediction of the real operating conditions of the plant when designing the installation. Because of the multiplicity of causes which determine the final result, this is often very difficult to achieve. In this paper a monitoring test of a bank service central plant equipped with an ice storage cooling system is presented. The measured data show remarkable differences from design stage expectations. This confirms the necessity to always schedule a commissioning adjustment of this kind of system.


This paper presents the results of an experimental investigation into the flow characteristics of miniature short-tube orifices of a type commonly used for fuel injection. From measurements of differential pressure and volumetric discharge it is shown that these devices are susceptible to a cavitation-induced instability phenomenon known as hydraulic flip. It was found that this instability is limited to orifices of length less than fourteen diameters and occurs at a critical pressure differential which varies as a function of the orifice l/d ratio and contraction parameter β. In addition, the performance of the device is examined in terms of the head loss characteristics and it is shown that the mechanisms associated with hydraulic flip have a significant effect on the efficiency of discharge.


In order to cope with safety issues regarding fisher vessels, a device is required with the real-time monitoring for the safety and risk factors for a capability of informing and alerting function. In embedded modules, there is a trouble that we should design device drivers and application programs for usage of the multi-function sensors in order to detect risk factors. In this paper, we designed hardware circuit and implemented control program of the sensor part using PIC18F, in order to control and process the input and output data of multi-function sensors without device drivers and application programs. We confirmed the operation of multi-function sensor module to generate output data according to sensor operation.


Future generations of wireless networks will offer unrivalled performance via unprecedented solutions: meta-surfaces will drive such revolution by enabling control over the surrounding propagation environment, always portrayed as a tamper-proof black box. The reconfigurable intelligent surface (RIS) technology, envisioned as the discrete version of a metasurface, can dynamically alter the propagation of the impinging signals by, e.g., steering the corresponding beams towards controllable directions. This will unlock new application opportunities and deliver advanced end-user services.However, this fascinating solution comes at non-negligible costs: RISs require ad-hoc design, deployment and management operations to be fully exploited. In this paper, we tackle the RISs placement problem from a theoretical viewpoint, showcasing a large-scale solution on synthetic topologies to improve communication performance while solving the dead-zone problem. Additionally, our mathematical framework is empirically validated in a realistic indoor scenario, the Rennes railway station, showing how a complex indoor propagation environment can be fully disciplined by an advanced RIS installation.


Both the Allies and the Germans detained and interned noncombatant "enemy" aliens during the war. When it suited their purposes, Nazi leaders looked to trade Jews for Germans being held by the Allies. The Nazis even built a special camp at Bergen-Belsen for Jews who could be used as bargaining chips. However, the U.S. State Department, under pressure from British and American intelligence, undermined a proposed exchange of such Jews for Germans from Latin America. Although large numbers of Germans were willing to be repatriated, American officials feared that doing so would help the Third Reich's war effort. They also suspected that the Jews being traded to the Allies were spies. Although the United States did eventually reverse its stance and tried to rescue these Jews, it was too late to save most of them.


Introduction Sawtooth crashes (SCs) are periodic relaxations of the core plasma which occur when the central safety factor, q0, is below 1. They consist of a ramp-phase during which temperatures and particle densities evolve slowly, and a fast crash that basically flattens these quantities inside the mixing radius, ρmix. For peaked pre-crash profiles, the SC decreases the values close to the magnetic axis and increases them just inside ρmix. At the inversion radius, ρinv, the values remain unchanged. SCs decrease the core confinement, but they also help to avoid impurity accumulation in the hot plasma centre, and to get rid of helium ash in a future fusion reactor. Large sawtooth crashes can trigger neoclassical tearing modes (NTMs), which gets more likely for long sawtooth periods. Sawtooth control therefore does not necessarily aim at avoiding sawteeth but at keeping them small and frequent.


This research forecasted the incidence rate per 100,000 elderly population with food poisoning, pneumonia, and fever of unknown origin in Khon Kaen Province and Roi Et Province in the northeastern part of Thailand. In the study, the time series forecasting with Box-Jenkins Method (SARIMA model) and Box-Jenkins Method with climate variables, i.e total monthly rainfall, maximum average monthly temperature, average relative humidity, minimum average monthly temperature and average temperature (SARIMAX model) was performed. The study results revealed that the forecasting accuracy was closely similar to the model without the climate variables in the combined analysis although such climate variables had relationship with the incidence rate per 100,000 elderly population with food poisoning, pneumonia, and fever of unknown origin. Therefore, the appropriate model should be the SARIMA model because it is easier for analysis but with higher forecasting accuracy than the SARIMAX model.


We derive the local statistics of the canonical ensemble of free fermions in a quadratic potential well at finite temperature, as the particle number approaches infinity. This free fermion model is equivalent to a random matrix model proposed by Moshe, Neuberger and Shapiro. Limiting behaviors obtained before for the grand canonical ensemble are observed in the canonical ensemble: We have at the edge the phase transition from the Tracy--Widom distribution to the Gumbel distribution via the Kardar-Parisi-Zhang (KPZ) crossover distribution, and in the bulk the phase transition from the sine point process to the Poisson point process. A similarity between this model and a class of models in the KPZ universality class is explained. We also derive the multi-time correlation functions and the multi-time gap probability formulas for the free fermions along the imaginary time.


The arguments between Mingjiao (The Confucian Ethical Code) and Ziran (Nature) has always been a core issue in the history of thought during that period of We-Jin dynasties. The arguments not only reveal the traces of the transformation of intellectualism at that period but also demonstrate the interactions of Confucianism and Taoism then. Chen Yin-ke wrote an article to discover and criticize that those feudal authorities use "Jiang wu tong" (Not the same?) to harmonize the conflicts of Mingjiao and Ziran so as to retain the right to rule with Mingjiao and gain the fame of pursuing transcendent metaphysics as the basis of leading extravagant life with Ziran. This insightful idea points out that Wei-Jin xuanxue and qingtan (intellectual discussions on lofty and nonmundane matters) indeed are closely linked to the mundane politics during that period. Scholars such as Tang Yung-tong, Tang Zhang-ru, Zhou Yi-liang and many more had discussed the same issue along the same reasoning and this demonstrated how far-reaching the influence and impact of this article. However, this author is of the opinion that the interpretation to the Wei-Jin dynasties' Jiangwutong can still be further studied, explored and interpreted; as such this author would attempt to discuss in depth Jiangwutong, with the anticipation that new light could be shed on this subject.


Introduction: Ectopic Breast Tissue (EBT) is still a condition seen as sporadic (2-5%), and it is often
delayed and ignored due to lack of awareness, whereas it may be exposed to malignant diseases. it must
be always kept in mind for differential diagnosis of an EBT. We think that this case report is important
because EBT associated with fi bro-adenoma is a quiet rare condition.


A novel clinical agent, LP-184 is being developed in conjunction with a dedicated machine learning-guided response signature, to allow optimal benefit of LP-184 through genomics-guided therapy. To define correlates of tumor genomics with sensitivity to LP-184, we used RADR™ (Response Algorithm for Drug Positioning and Rescue), a proprietary artificial intelligence (AI)-driven platform, and CellMinerCDB (cross database)™, a systems biology platform integrating molecular and pharmacological datasets on cancer cell lines. The input for our correlational analyses, include LP-184 IC50 data on NCI-60 cell line panel representing drug response, and multi-omics data on these cell lines. CellMinerCDB™ based analysis of LP-184 using a Lasso regression model generated a 38 gene response signature that included expression of APP, NEK6, EGFR, SQSTM1, SLC25A42, SLC16A10, POLD1, SMARCC1, POLG2, CHEK1. In building the model, the signature demonstrates a sensitivity R2 = 0.98 between observed and predicted IC50 values. Additional omics data including methylation and protein levels validate the relevance of several signature genes: APP, NEK6, EGFR, SQSTM1. Concurrently, a RADR™ based analysis of LP-184 using an Artificial Neural Network (ANN) classifier model generated a 10 gene response signature with PTGR1 and PTPN14 as the top weighted genes by relative importance. To establish a signature with highest possible sensitivity, we integrated these 2 additional genes in the 38 gene signature, creating a modified 40 gene signature now having an R2 = 0.99. We next used laboratory experimental studies to measure the performance of this signature. Using an independent set of 18 cell lines not used in signature development, we obtained IC50 values and categorized cell lines as sensitive or resistant. Our in silico results matched in vitro experimental results for 13/18 cell lines (72 percent accuracy). We further applied this 40 gene signature to interrogate 1036 cell lines representing a spectrum of tumor types in the Cancer Cell Line Encyclopedia (CCLE) and obtain a signature-derived IC50. The predicted IC50 ranges from 2.7nM to 114.6uM. The least responsive tumors represent hematological cancers, reproducing the observations made in the NCI-60 panel. 92 of 116 (79%) hematologic cancers in the CCLE database showed a predicted IC50 above 1µM with a median of 3.4uM. The top 279 cell line records with a predicted IC50 below 100nM represented solid tumors with NSCLC, renal, CNS and head & neck cancers as the most sensitive. In conclusion our results demonstrate that the development of LP-184 guided by tumor gene expression patterns modeled using a combination of algorithms and signatures provides a valuable component to the armamentarium of drugs in diverse solid tumors. Citation Format: Umesh Kathad, Aditya Kulkarni, Jean Philippe Richard, Terri Lehman, Rama Modali, Kishor Bhatia, Panna Sharma, Fathi Elloumi, Yves Pommier, William C. Reinhold. Machine learning-derived gene signature predicts strong sensitivity of several solid tumors to the alkylating agent LP-184 [abstract]. In: Proceedings of the Annual Meeting of the American Association for Cancer Research 2020; 2020 Apr 27-28 and Jun 22-24. Philadelphia (PA): AACR; Cancer Res 2020;80(16 Suppl):Abstract nr 2090.


The drug development process, from discovery to safety studies, aims to bring efficacious and safe drugs to market. Unfortunately, this ambition is often thwarted by unanticipated adverse effects that are not detected by the current drug-testing paradigm. Cardiotoxicity ranks as one of the primary causes of drug recalls, an extraordinarily costly event in terms of both the manufacturer's bottom line and the negative patient outcomes [1]. As such, developing more predictive cardiotoxicity assessments is a main focus of research. Currently, preclinical cardiac assessments mainly consist of animal studies and heterologous expression systems of human cardiac ion channel in noncardiac cell lines. Animal models provide valuable in vivo pharmacodynamic and pharmacokinetic data, and their genes can be precisely manipulated for mechanistic investigations. However, species–species differences hinder their applicability as a model of human patients. For example, rodents have heart rates 3–10 times faster than humans [2], virtually no delayed rectifier potassium IKr (human ether-a-gogo-related gene [hERG]) current, and animal ion channel expression and action potential profiles are generally distinct from those of humans [3]. Human-specific drug screening data have been obtained using primary heart cells and tissue, tumor-derived immortalized mammalian cardiac cell lines, and heterologous expression systems in which noncardiac cells (Chinese Hamster Ovary or Human Embryonic Kidney) are transfected to express an individual human ion channel, most commonly the hERG channel. Most of the cardiotoxicity/arrhythmia safety screens performed to date have employed the latter as a means of assessing the potential for acute drug-induced electrocardiogram (ECG) abnormalities. These human-specific models are limited by genetic instability and the absence of important cardiac cell characteristics. Taken as a whole, the preclinical paradigm is able to predict 70–90% [1] of human patient drug effects, yet many promising drugs are triaged early in development and some cardiotoxic drugs still enter the market. To minimize the use of animal models and to improve the precision of risk prediction, various alternative platforms have been developed for drug safety evaluation. Here, we discuss the current challenges to the cardiotoxicity and drug discovery fields, the state of the art and we envision a more predictive human cardiac model.


There are many approaches for the description of dissipative systems coupled to some kind of environment. This environment can be described in different ways; only effective models are being considered here. In the Bateman model, the environment is represented by one additional degree of freedom and the corresponding momentum. In two other canonical approaches, no environmental degree of freedom appears explicitly, but the canonical variables are connected with the physical ones via non-canonical transformations. The link between the Bateman approach and those without additional variables is achieved via comparison with a canonical approach using expanding coordinates, as, in this case, both Hamiltonians are constants of motion. This leads to constraints that allow for the elimination of the additional degree of freedom in the Bateman approach. These constraints are not unique. Several choices are studied explicitly, and the consequences for the physical interpretation of the additional variable in the Bateman model are discussed.


This article analyzes the trends and conditions of imprisonment in Nigeria. The analysis reveals an upsurge in prisons admissions, and a high proportion of detainees and inmates remanded pending trial. High rates of custodial morbidity, mortality and overcrowding, poor health care, and inadequate nutrition and food prevail in Nigerian prisons. The rate of execution increased between 1984 and 1990 under the Buhari and Babangida military regimes. Nigeria needs to deliberately adopt socioeconomic and political policies that help to prevent crimes and enhance the correction of offenders-instead of the current preoccupation with repressive policing and cruel and unusual punishments within the nation's prisons.


Researchers have discovered a number of risk factors associated with adolescent dating violence; these include child maltreatment and high levels of conflict in teen dating relationships. This study examined relationships among adolescent dating violence, family violence, community violence, dating history, academic history, and various forms of self-efficacy among 306 high school and university students (age 16 to 19 years). Results showed that psychological, physical, and sexual dating violence were common occurrences among these students, that both males and females admitted perpetrating dating violence, and that dating violence was related to involvement in community violence. Young women in high school who were victims of any form of dating violence demonstrated lower levels of dating self-efficacy (i.e., less confidence in their ability to secure and maintain dating relationships and to protect themselves from dating violence) and those who were victims of sexual dating violence had lower levels of physical selfefficacy. Young men in high school who had perpetrated psychological dating violence had lower academic self-efficacy. Implications for intervention and prevention programs are discussed. Background Adolescence is a significant period of development associated with a variety of new experiences and challenges. Within this period of the life span, the formation of intimate dating relationships is important to the continued healthy development of the individual (McCabe, 1984). Not all dating relationships, however, lead to a positive developmental trajectory. A


Submitted for the DPP17 Meeting of The American Physical Society Quantification of MagLIF stagnation morphology using the Mallat Scattering Transformation1 MICHAEL GLINSKY, MATTHEW WEIS, CHRISTOPHER JENNINGS, DAVID AMPLEFORD, ERIC HARDING, PATRICK KNAPP, MATTHEW GOMEZ, Sandia National Laboratories — The morphology of the stagnated plasma resulting from MagLIF is measured by imaging the self-emission x-rays coming from the multi-keV plasma. Equivalent diagnostic response can be derived from integrated rad-hydro simulations from programs such as Hydra and Gorgon. There have been only limited quantitative ways to compare the image morphology, that is the texture, of the simulations to that of the experiments, to compare one experiment to another, or to compare one simulation to another. We have developed a metric of image morphology based on the Mallat Scattering Transformation, a transformation that has proved to be effective at distinguishing textures, sounds, and written characters. This metric has demonstrated excellent performance in classifying an ensemble of synthetic stagnations images. A good regression of the scattering coefficients to the parameters used to generate the synthetic images was found. Finally, the metric has been used to quantitatively compare simulations to experimental self-emission images. 1Sandia National Laboratories is a multi-mission laboratory managed and operated by NTESS, LLC., a wholly owned subsidiary of Honeywell International, Inc., for the USDoEs NNSA under contract DE-NA0003525. Michael Glinsky Sandia National Laboratories Date submitted: 14 Jul 2017 Electronic form version 1.4


In this note, we generalize the results of arXiv:0901.2703v1 We show that all one-way quantum finite automaton (QFA) models that are at least as general as Kondacs-Watrous QFA's are equivalent in power to classical probabilistic finite automata in this setting. Unlike their probabilistic counterparts, allowing the tape head to stay put for some steps during its traversal of the input does enlarge the class of languages recognized by such QFA's with unbounded error. (Note that, the proof of Theorem 1 in the abstract was presented in the previous version (arXiv:0901.2703v1).)


To obtain groundwater sample in monitoring wells with large depth and small diameter quickly,we developed air-exchange underground water sampler. The sampler use water pressure to drive underground water into sampling tube and then use compressed air to press the water sample out of the well to ground surface. For single cycle water sampling in 550 m well,the average water sampling volume is 20 L per time; while for continuous water sampling in 500 m well,the average water sampling volume is 40 L per time. This paper gives a detail introduction to the principle,design and development and test condition of the sampler.


Influence of the Sinu River and the Caribbean Sea over the Cispata lagoon system. The influence of the Sinu River and the Caribbean Sea over the Cispata lagoon system was studied through annual and interannual analysis, as well as the tendency of hydrological (precipitation, discharge), and marine (SST, level) time series. The hydrological series were correlated with ONI, NAO and PDO macroclimatic indices, and, from data logging of flow stations down of Urra I dam, their effects over the lagoon system were studied. No significant correlation between the precipitation and ENSO was found. The flow of the river basin highlands contribute with 50% of the one released. The flow coming into the lagoon system displayed a monomodal cycle. Positive flow anomalies


Varicose vein disease (VD) of the lower extremities is the most common pathology of the peripheral vessels: 26-38% of women and 10-20% of men of working age suffer from it. The annual increase of new cases of VD among the inhabitants of industrialized countries reaches 2.6% among women and 1.9% among men. Its course is accompanied by a number of complications and a high level of disability of patients, which, in turn, is associated with significant economic costs. These circumstances make the development of an effective system for diagnosing VD an important medical and social problem.


Summary Using a double agar overlay, MSGV produced discrete spherical plaques in mouse embryonic fibroblasts, but not in chick embryo, HeLa or L cells. Plaques appeared about 36 hours after seeding as single large rounded inclusion-laden cells, surrounded by wide clear zones. Centrifugal expansion by progressive involvement of adjacent cells resulted in plaque diameters of 0.2 to 0.8 mm by the 6th day. Fluid medium from infected bottle cultures commonly contained 1 × 107 PFU/ml. A linear relationship was found between plaque counts and virus dilution. The virus was markedly stable when stored for 5 hours in PBS with 2% calf serum, but rapid loss of titer occurred if serum was omitted. Virus titer and CPE production in vitro were not significantly altered during 120 passages, but pathogenicity for mice was lost after about 36 passages.


The kinetic theoretical results for a homogeneous plasma in a uniform magnetic field are discussed qualitatively. The role of the mean cyclotron radius as a natural long-range cutoff is clarified. A relationship between a critical frequency for ionic sound waves and the magnetic-field intensity is predicted.


In an attempt to understand better the failure of Islamism to exercise any significant impact on the trajectory of Indonesian politics through the twentieth century, this article examines the development of Indonesian Islamist thought in the early twentieth century and compares it to the growth of secularist nationalist thinking.  Islamist thinking was slow to arrive at a consciousness of Indonesia as specific national place and homeland.  By the time Islamist thinkers had begun to develop a clearer sense of their own political project, secular nationalist thinkers (often indifferent to and sometimes fiercely opposed to Islamic and Islamist ideas about the relationship of state to religion) had already established the unassailable primacy of  the idea of Indonesia as an independent sovereign state-in-the-making and as the vehicle for Indonesians to become both modern and prosperous.  Islamists thereafter had no option but to seek to accommodate their thinking to the dominant paradigm of the idea of Indonesia.


The present invention relates to a wind turbine (10), which comprises a wind tower, a nacelle rotatably disposed and arranged on the nacelle on the tower in a helicopter landing pad, wherein the wind turbine having a wind wheel and a locking means the wind turbine rotor blade having at most two, of the locking means for locking the wind turbine blade in a position extending horizontally the rotor, the helicopter landing pad and disposed on the nacelle, so that the cross section of the tower section in the plan view entirely within the outer contour of the helicopter landing pad.


A high-power medium-frequency heating power source for reflowing in the tinning technique comprises an incoming switch, an outgoing switch, a phase-shift multi-winding rectifier transformer, a reduction transformer, a plurality of power units and a controller, wherein the controller is connected to the incoming switch, the outgoing switch, the phase-shift multi-winding rectifier transformer and the power units through control lines, each power unit comprises a diode three-phase full-wave rectifier bridge, a voltage stabilized capacitor and an IGBT (insulated gate bipolar transmitter) inverter bridge, the phase-shift multi-winding rectifier transformer is electrically connected to input sides of the power units, and output sides of the power units are connected serially and sequentially and connected to the reduction transformer. The high-power medium-frequency heating power source combines advantages of resistance heating and induction heating, has higher heating efficiency of the resistance heating, also is alternating current of a certain frequency, and solves the problems of wood grains and the like. Further, the phase-shift multi-winding rectifier transformer is used for power input, so that the high-power medium-frequency heating power source is higher in power factor, low in harmonic content and symmetrical in three-phase power supply, and has no evident problem of electricity quality.


Internet connects people along through enterprise and social verbal exchange like Mobile banking and electronic commerce. In the recent technology world, the growing Internet of Things (IoT) is all concerning connecting equipment and organizations through sensors, actuators and other electronic components. So, critical data from those systems can be accumulated and moves taken to enhance human productiveness and potency. IoT takes the object of inter-communication to a full high-level architecture. While IoT guarantees the manner to scale back wastes, fees and inconvenience while growing efficiency, the maximum vital elegance of this on coming years. Also, it enhances smart world to persuade environmentally cleaner, effective and a stronger high-quality of life


The culmination of this research is examining various markers of lexical cohesion in the October 2021 issue of Intisari magazine. The various types of writings in the magazine have a mission to provide enlightening information for the readers. The coverage of Intisari magazine is quite broad and in-depth—covering history, geography, and tradition—allowing it to be more complete and interesting to study. Starting from aspects of form, vocabulary, sentences, inter-sentence connections, and sentence structure. This is the basis why researchers take the essence as the object of study. In his analysis, the researcher uses the Sumarlam concept as a reference for the classification of lexical cohesion markers in discourse. This study uses a qualitative descriptive method with the October 2021 edition of Intisari magazine as the object of study. The data collection method used literature study with analytical descriptive technique as a data analysis technique. The results of the study showed various markers of lexical cohesion, including: (i) repetition, (ii) synonymy, (iii) antonymy, (iv) hyponymy, (v) collocation, and (vi) equivalence. Variations in the use of lexical cohesion in Intisari magazine are a form of applying the types of lexical cohesion markers in discourse.


Abstract The digital divide affects many nations of the developing world. The term encompasses inadequate funding, a lack of necessary computer and Internet skills, and a lack of English-language proficiency that hinder expansion and use of digital information resources. Visionary individuals and organizations can assist these countries with their information needs. Aggregated full-text databases serve as a prominent tool in closing the digital divide because they provide important research resources. Participating organizations must demonstrate the value of these resources to users and supply essential training to ensure success with electronic resource initiatives.


The defects induced by neutrons (E >0.1 MeV) and Ar+ beams (E = 30 KeV) on the atomically pure surface and in the near-surface volume of platinum were studied using field ion microscopy. Experimental results of radiation defect formation in surface layers of materials initiated by neutron bombardment (Pt, E > 0.1 MeV) and ion implantation (in Cu3Au: E = 40 keV, F = 1020 ion/m2, j = 10∼3 A/cm2) are considered. Quantitative estimates of the size, shape, and volume fraction of atomic displacement cascades formed during various types of irradiation in these materials are obtained. It is shown that the average size of radiation clusters after irradiation of platinum with a fast neutron fluence of 6.7« 1022 m−2 (E > 0.1 MeV) is about 3.2 nm. The experimentally established average size of a radiation cluster (disordered zone) in an alloy after ion bombardment is 4 • 4 • 1,5 nm.


Gestures shed light on thinking-for-(and while)-speaking. They do this because they are components of speaking, not accompaniments but actually integral parts of it. Much evidence supports this idea, but its full implications have not always been recognized. For comparison, cf. modular-style modeling in de Ruiter (2000) and Kita & Özyürek (2005), based on the theory of speech production in Levelt (1989). Modular theory and its spinoffs are incompatible, we have argued, with the integration of gesture into speaking (McNeill, 2000; McNeill & Duncan, 2000). They require a fundamental separation of speech and gesture; the 'modules' exchange signals but cannot combine into a unit. The growth point (GP) hypothesis, which we describe here, is designed in contrast to explicate this integral linkage. In a GP, speaking and gesture are never separated, and do not occupy different brain processes that must in turn then be linked (cf. the brain model section, below). A key insight is that speech on the one hand and gesture (or, more broadly speaking, global-imagistic thinking), on the other, when combined into a GP, bring together semiotically opposite modes of cognition at the same moment. This opposition, and the processes that speakers undergo to resolve it, propels thought and speech forward; semiotic contrasts are a key component on a dynamic dimension of language. It is in this mechanism that we seek insights into language disorders. We explore four situations—disfluent (agrammatic) aphasia, Down's syndrome, Williams syndrome, and autism. Each can be seen to stem from a breakdown, interruption or inaccessibility of a different part of the GP, and from a disturbance of the dynamic dimension in general. Considered together, they manifest—by interruption—aspects of the processes of thinking-for/while-speaking itself. We have not attempted to review gesture study, the growth point, the psycholinguistics of speech production, or language disorders, but do spell out some implications of a new paradigm in which language and cognition are embodied (cf., Johnson, 1987) and dynamic, and show how a theory within this paradigm, the growth point, leads to new insights into four language disorders.


Abstract After a short critical presentation of the position of phonetics as a scientific discipline, it is shown how to develop the concept of 'disclosure of phonetic information' (phonetische Informationserschlieβung). One can see that it is possible to understand the 'signal phonetics' (Signalphonetik) as a process of disclosure of phonetic information along the fields of manifestation of phonetic information (Manifestationsbereiche) within the chain: speaker, transmission medium, and hearer.


Dear Editor, The study by Mitra and colleagues regarding the ACEM trainee research requirement (TRR) provides important insights into the perceived value of the two options available to trainees: the coursework pathway (CP) and the trainee research project (TRP). A significantly higher proportion of trainee respondents rated the CP as being useful for meeting the College's learning objectives for research, with many commenting that it is an easier and quicker alternative to the TRP. These results help explain the overwhelming popularity of the CP. ACEM data (Table 1) indicate that over 90% of trainees now choose this option, with only 34 TRPs completed in the 12 months to July 2014 (ACEM Trainee Research Committee, pers. comm., 2014). Anecdotally, many elect to incorporate CP subjects into higher degrees, such as Masters of Public Health. The resounding message from Mitra and colleague's study is that trainees consider the TRP to be a less efficient and effective means of achieving the TRR. Other commentators have previously asserted that the bar for the TRP is set too high, thereby discouraging trainees from participating in research and disadvantaging those who do. The primary purpose of the TRR should be to meet the College's learning objectives for research. While the College has a responsibility to encourage scientific discovery, the TRP is a blunt instrument for doing so. A 2009 review, conducted prior to the introduction of the CP, established that the overall quality of TRPs was poor. For these reasons, alternate strategies (beyond the TRR) are required to foster trainee interest in research and grow the clinical academic workforce. At a minimum, the College must comply with the Australian Medical Council standards for specialty education. These require that all training programmes include 'formal learning about research methodology, critical appraisal of literature, scientific data and evidence-based practice, and encourage the trainee to participate in research'. Australasian critical care colleges have adopted varying approaches to meeting this standard. For instance, all trainees in intensive care are required to undertake at least one formal research project. In anaesthetic training, the options are performing a clinical audit or critical appraisal, undertaking a postgraduate degree in research or contributing to a research project culminating in publication in a peer-reviewed journal. ACEM's current approach is laudable because it gives trainees choice. While Mitra and colleagues have established that the CP is the preferred option of trainees, accessing recognised courses is not without challenges (mainly related to time and cost). For this reason, concerted efforts should be made to both improve access to the CP, and enhance the experience (and therefore attractiveness) of the TRP. Cost subsidisation is one mechanism of meeting the former objective, and might be achieved through partnerships with local universities. Given that EM trainees frequently provide voluntary teaching and supervision of medical students, universities could recognise this by subsidising


We report on the effects of using various doping 3d, 4d and 5d transition metal elements on the stability of the supersaturated FCC Ag–Cu solid solution prepared by mechanical alloying. We find that the addition of W does not have any influence on the stability of the Ag–Cu solid solution. Moderate effects are observed for Ru, Fe and Co, while the addition of Ni partially destabilizes the Ag–Cu solid solution. The results are discussed in the framework of kinetic and thermodynamic processes.


In this research, a cascaded adaptive neuro-fuzzy inference system (ANFIS) with nonsingular terminal sliding mode is developed for drawing out maximum power from 250 W photovoltaic array. Aiming to extract the maximum energy, a boost converter is utilized as voltage regulator between PV system and load. A cascaded voltage/current regulator based proportional integral(PI) and nonsingular terminal sliding mode control(NTSMC) forms the duty cylce of boost chopper. The proposed control algorithm is tested under normal condition as well as under sudden change of atmospheric variation. Furthermore, the results were compared with ANFIS-PI. The proposed controller has improved the robustness, steady state, and has suppressed the chattering problem.


Introduction The Ukrainian economy will not be able to take a worthy place in the world's economic space without the solution of problems concerning effective industrial production development. The production facilities of Ukraine are concentrated in industrial cities, where the lack of investment resources leads to exploitation of obsolete fixed assets at the industrial enterprises with a high degree of physical deterioration and natural environment pollution, which negatively affects the health status of population, fertility and mortality rates, life expectancy. Functioning in the framework of the state industrial policy, an industrial city has to be given certain economic levers and financial resources to address these problems at the local level. One of the most powerful economic levers is taxation, which at the city level is represented by an institute of local taxation. Forming an effective and self-sufficient local taxation system is one of the main tasks of Ukrainian tax system improvement. Nowadays the collection of local taxes and fees is regulated by the Tax code, with the introduction of which the situation in the sphere of local taxation has not significantly changed: the code does not provide for the significant sources of tax revenues and the levers of influence on socioeconomic development at the local level. The scientific interest is how to form the local taxation system, appropriate for use at solution of problems of territories, in particular industrial cities.


It is an important question that how to find the juggling to the DNA data and how to ensure the data is right.This paper brings forward a method to deal with this question based on digital signature,and designs a full set of the means to add,examine and filter the digital signature.This method adds digital signature to the DNA sequences,and finds the juggling by checking it before using the data.The experiments show that this means can find the juggling effectively and the sequence adding the digital signature is same with the primal sequence,which can let the attacker pay less attention to them.


STUDY DESIGN
Retrospective case-control study OBJECTIVE.: To evaluate specific functional disabilities after short- and long-level lumbar fusion.

SUMMARY OF BACKGROUND DATA
The Oswestry Disability Index (ODI) cannot represent all types of functional disabilities observed after lumbar fusion and a region-Specific Functional Disability Index (SFDI) is necessary.

METHODS
We examined the differences in postoperative functional disability between 81 patients who underwent ≥ 3-level lumbar fusion (group I) and 70 age- and sex-matched patients who underwent 1- or 2-level lumbar fusion (group II). The ODI and Visual Analogue Scale (VAS) were assessed pre- and postoperatively. The SFDI was assessed after lumbar fusion. We evaluated intergroup differences in postoperative VAS, ODI and SFDI scores during 3-year follow-up. Each mean score was evaluated separately for the 10 ODI and the 12 SFDI items, and we evaluated the changes observed in these scores over the 3-year follow-up.

RESULTS
The mean intergroup preoperative ODI and VAS scores were similar. The mean postoperative intergroup VAS scores were similar; however, the mean postoperative ODI and SFDI scores were significantly higher in group I than in group II at 1-year (p<0.001, p<0.001, respectively) and 3-year follow-up (p = 0.037, p<0.001, respectively). Among 10 ODI items, group I showed significant disability with regard to 6 items at the 1-year follow-up compared with group II, but only showed significant disability with regard to 1 item at the 3-year follow-up. Among the 12 SFDI items, group I showed significant disability with regard to all 12 items at 1-year follow-up compared with group II, as well as significant disability with regard to 9 items at 3-year follow-up.

CONCLUSION
The SFDI is more sensitive than the ODI in assessing functional disabilities based on the levels of fusion. Most SFDI items indicated continued significant disability in patients with long-level lumbar fusion even 3 years postoperatively.

LEVEL OF EVIDENCE
3.


Accounting for about one thirds of the national territory, inland watersheds are found completely in West China, with a severe and unique eco- enviroment. Land resource exploitation and social- economic sustainable development are closedly linked in this region. Taking as an example the Hexi Corridor in Gansu Province, this paper briefly analyzes eco- environmental problems in land resource exploitation, and comes up with the chief tasks to cater to the great development in West China in the new century and to the sustainable development of land resources and management of eco- environment. The tasks are: determining long- term stategic objects for the balance of water and land resources in the region; establishing functioning zones of land use in each of the watersheds and reasonable systems and mechanisms of distribution and utilization of water and land resources; emphasizing and securing a synchronous monitoring of quality and quantity of land resources; optimizing land use structure and strengthening control of land use to reverse the shrinkage of aquifer zones and ecological protection belts; striving to start the project of beautifying the land in the region.


OF THE DISCLOSURE A process is provided for producing graphite whiskers which comprises passing a hydrocarbon gas and an active gas, viz, carbon dioxide or water, in a volume ratio ranging between about 10 to 400 parts hydrocarbon gas to one part active gas through a pyrolysis zone having a substrate therein for the growth of whiskers thereon, the pyrolysis Zone being maintained at a pressure less than atmospheric with the temperature in the pyrolysis zone initially being maintained above about 700° C. to pro mote nucleation of the whiskers and thereafter maintained above about 1200° C. to provide for whisker growth. This is a continuation-in-part of application Ser. No. 413,637, filed Nov. 24, 1964, now abandoned. The present invention is concerned with pyrolytic graphite whiskers or filaments and, more particularly, with improved processes for producing such pyrolytic graphite whiskers through the decomposition of hydro


Summary Effects of equine chrionic gonadotrophin (eCG) upon reproductive traits of Van cats during the non-breeding season were investigated herein. In the non-breeding season (October), a total of 18 queens were divided equally into three experimental groups, as follows: one ml of 0.9% saline solution, as single placebo injection (intramuscularly, i.m.) was given to queens, as control (Group I, n=6), while single (250 IU, i.m.) or split dose of eCG (75 IU/daily for 5 d) was injected in Group II and III (n=6 each), respectively. Data from the rates of oestrus, days of mating, pregnancy, parturition, litter size, survival of kittens and lactation period were recorded. The oestrus rates (100% both) in Groups II and III were significantly (P<0.01) higher than those in controls (33.3±21.1%). Days of mating (9.0±1.0, 4.7±0.7 and 5.8±0.4 d) were significantly (P≤0.01) different between the groups (Group I, II and III, resp.). Pregnancy period (65.8±0.5 d) was significantly (P<0.05) longer in Group III ((65.8±1.0 d) than in Group II (62.4±1.0 d) and controls (62.5±0.5 d). The litter size tended (p=0.062) to be higher in Group II (4.6) than those in Group III (2.6) and controls (3.0). Finally, the lactation period (105.2±2.6 d) was significantly (P<0.05) longer in Group III than those in Group II (94.6±1.7 d) and controls (95.0±5.0 d). Findings suggest that; both single and split eCG injections were equally highly effective for induction of fertile oestrus in endemic Van cats in non-breeding season.


Objective:To evaluate the efficacy and safety of electroacupuncture on Jiaji Points in treating lumbar disc herniation and analyze the current status of clinical research.Methods:Retrieving the PubMed,OVID,Cochrane Library,CBM-disc database,CNKI database,VIP database,we collected 215 literature of the manipulation treatment of lumbar disc herniation,with 6 studies met the inclusion criteria.Cochrane systematic review was used to quality evaluation.The 6 studies were used by RevMan 4.2 for Meta analysis.Results:The 6 studies included a total of 772 patients,and the OR of the summary cure rate was 2.53 and 95% CI was [1.87,3.42].The cure rate in treatment group(treated by electroacupuncture on Jiaji points) was superior to control group(conventional acupoints plus EA)(P0.01).The OR of the summary total effective rate was 3.61 and 95% CI was [2.03,6.43],and the total effective rate of treatment group was superior to control group(P0.01).One documents using 82 samples for evaluating efficacy endpoint by analyzing the MPQ difference before and after treatment,summary OR is 2.20 and 95% CI is [0.76,3.64],the treatment group was superior to control group(P0.01).One documents using 112 samples for evaluating efficacy endpoint by analyzing the VAS value,summary OR is-1.32 and 95% CI is[-1.33,-1.31],the treatment group was superior to control group(P0.01) in pain improvement of lumbar disc herniation.Conclusion:At present,the documents included in this study have shown that electroacupuncture on Jiaji points for treating lumbar disc herniation is safe and effective,and both cure rate and the effective rate are much better than conventional acupoints plus EA.But in improving the degree of pain,the effect of electroacupuncture on Jiaji points is still not sure because of the small number of included studies,needed high-quality evidence to further verify.


Papineau's procedure is an open method of a bone grafting with autogenous cancellous bone chips. It is popular in France but the report of this operation is rare in Japan.Our patient, a thirty-six-year old woman, developed osteomyelitis of the left tibia after open fracture, which ended up with a wide ranged defect-pseudarthrosis two years after the injury.A bone grafting was necessary for osteosynthesis, but the scar was such a wide, deep and hard one, so that a common blocky subcutaneous bone grafting was hesitated.Therefore the Papineau's procedure was used and good result was obtained.Four months after the operation weight-bearing was allowed with Hoffmann's external fixation device and bone union was completed within nine months.


Roy Pearson examines a valuable new Web-based application – the IFs model – that enables forecasters to deal with the future impacts of changes in their organization's external environment. These can be product or market changes, but technological, demographic, social, political, and environmental changes as well. Of course, no business has the time, budget, and expertise to build a global model of the scope and size necessary to quantify the effects of all of these changes, especially for decades down the road. So the IFs model offers a way for you to map future alternative paths of major concern to you or your organization, providing a quantitative foundation for focusing discussions and planning. And it's free to the public. Copyright International Institute of Forecasters, 2011


A Wireless Sensor Network (WSN) is a network which comprised of multiple low cost sensor nodes. In WSN, each sensor is deployed in a different location for a specific purpose. Due to unstable conditions, sensors are unable to perform an anticipated result. At this stage, we totally loose our security and it shows inaccuracy result. So we concentrate on the mutual trust between the source-to-sink and vice versa in a WSN. Trust has been recently suggested as an effective security mechanism for managing each sensor node. In this paper, we investigated some stable trust management techniques for a high trust in WSN. From the techniques we believe to form a strong trust model on sensor communications over a WSN. In this paper, we also evaluated the finest trust model for WSN using TRMSim-WSN 0.4 Simulator. This simulator consists of various trust models and each model performs the different results. The analytical result demonstrates its effectiveness in managing trust relationships and techniques.


Objective To study the relationship between velocity of middle cerebral artery(MCA),severity of disease and watershed infarction(WSI) in patients with extracranial internal carotid artery(EICA) stenosis or occlusion.Methods Transcranial Doppler(TCD) was used to detect the mean velocity(MV) of MCA in 120 patients with EICA stenosis or occlusion.The National Institutes of Health Stroke Scale(NIHSS) was used to evaluated the patients′ condition.And CT or MRI was used to diagnosised the WSI.Results MV of MCA was severe reduced in 10 cases,middle reduced in 38 cases,and mild reduced in 42 cases,while there were 30 cases with normal MV.The scores of NIHSS in the four groups(12.5±4.7,3.9±4.8,3.2±4.7,2.4±4.9 respectively) had significant different(P0.01).The incidence of WSI in the four groups were 40%,63%,38%,27% respectively,the different was significant(P0.05).The incidence of WSI in the MV middle reduced group was significantly higher than those in the other groups.Conclusion The lower MV in MCA with severer EICA stenosis or occlusion,the disease condition is more severity,the incidence of WSI is also high.


A wide variety of special techniques is now employed in clinical electroencephalography (Kaufman and Watson, 1949) to unmask latent abnormalities in cerebral electrical activity. One of the most useful of these is clinical and electrical observation of the patient while asleep (Gibbs and Gibbs, 1941, 1947; Wyke, 1949), and this provides information of physiological as well as of direct clinical interest. As observations during natural sleep are inconvenient, artificial methods of sleep induction have been sought, and such various substances as paraldehyde, sodium amytal, " nembutal," sodium pentothal, sodium evipan, and seconal sodium have been employed to this end. The most satisfactory agent for this purpose in our hands is seconal sodiumt, suggested by Gibbs and Gibbs (1949), and our experience with it now embraces 100 cases. On the basis of this experience the present communication discusses the cyclical changes that this agent induces in the human electroencephalogram. It is restricted to the normal physiological changes. The technique for clinical testing and the abnormal variations are discussed elsewhere.


Indoor navigation has received much attention in academics and industry in recent years. Previous methods often attempt to locate users with various localization algorithms in combination with an indoor map, so they need expensive infrastructures deployed in advance. In this study, we propose to utilize existing indoor objects attached RFID tags and the reader to navigate the user to the destination, without need of any extra hardware. The key insight is that the personal movement takes an impact on the Doppler frequency shift values collected from the indoor objects when getting close to the tag. Such local human-item spatial relation is leveraged to infer the users position and further navigate user to destination step by step. We implement a prototype navigation system, called RollCaller, and conduct comprehensive experiments to examine its performance.


An adaptation offamily sculpting can be used as a supervision intervention with family therapists in training who are struggling with families and/or family members with whom they feel stuck orfrustrated. How to conduct thefamily sculpting method of group supervision is presented.


The essay is mainly through following three parts to analyze lady Chatterley's reasonable affair because of her husband's disability and his maltreatment to lady Chatterley: I.Sir Clifford's disability in his body,esp.completely losing his sexual ability partly destroyed their marriage life and to a great extent leads to lady Chatterley's love affair with Michaelis;II.Sir Clifford's disability in his mind caused by his maiming body and his maltreatment to his wife is the most important reason which leads to lady Chatterley's final betray to their marriage;III.Living with her disgusting non-human husband,lady Chatterley comes to realize her genuine living goal——leading a free life and she consequently takes action——runs after her freedom,her freedom both in body and mind.


Potter and Burnley (2002) describe agricultural multifunctionality as 'producing not only food but also sustaining rural landscapes, protecting biodiversity, generating employment and contributing to the viability of rural areas'. This concept is commonly accepted as part of the resource function of forests and woods (Buttond 2002), and recent discussions in the academic agricultural literature have highlighted its value to support marginal farming in the European Union (Vos and Meekes 1999; Rizov 2004). Wiggering et al. (2006) demonstrated how this multifunctional concept allows for continued financial support of marginal farmers whilst abiding by World Trade Organisation (WTO) agreements to reduce trade barriers and subsidies, achieving this through farm support of non-food products, such as public goods or rural development. An example of where this is happening is upland agriculture in Cumbria, England.


ABSTRACT.The paper focuses on the concept of 'terminological incongruency' in legal language that has been largely debated by jurists, translation theorists, legal translators and drafters. It is meant both as a theoretical and practical study in legal translation. Its purpose is to briefly present and illustrate effective translation strategies that may compensate for and help legal translators deal with this peculiarity of legal texts, namely 'terminological incongruency' which is actually the overt linguistic projection of an inherent 'conceptual incongruency' specific to legal language. The practical examples provided and the comparative linguistic analysis associated are based on English-Romanian and respectively Romanian-English legal terms and expressions.Keywords: terminological incongruency, conceptual incongruency, functional equivalent1. IntroductionThe legal language is subject to continuos change, in all its diverse linguistic subdivisions - the language of laws, regulations and treaties, the contractual language, the language of the court or that of scholary writings. It is the responsibility of legal translators and drafters to permanently update their translation strategies according to the most recent legal translation theories. Apart from being wellinformed as regards the latest approaches to legal translations, they may also use these theoretical sources of information to improve the quality of their practical work.Our study undertakes this particular challenge - to extract from the speciality literature covered new translation strategies and test their practicability and effectiveness in the practical field of legal translations. Due to the limited extent of our paper we are to focus primarily on the aspect of 'terminological incongruency' and its associated concepts, as well as on specific translation strategies meant to compensate for it.1.1 'Terminological incongruency' in legal languageAuthor of bilingual and plurilingual legal dictionaries, of comprehensive studies on legal lexicography and legal translation theories, Susan Sarcevic addresses the concept of 'terminological incongruency' in legal language, in one of her latest books, New Approach to Legal Translation) Making reference to the fact that each legal system is the product of a particular history, culture, socio-economic principles and has its own conceptual system, the author concludes that "legal terminology of different legal systems is, for the most part, conceptually incongruent."2 Since legal terms are the only signs expressing legal concepts that make reference to particular objects in the legal realia, one cannot practically address the issue of 'terminological incongruency' without implicitly consider the underlying concept of 'conceptual incongruency.' Unlike the complex class of exact sciences (mathematics, physics, chemistry, biology, medicine etc.) where the systems of concepts is the same in all languages, universal, independent of national and cultural boundaries and therefore the process of translating special-purpose texts is practically reduced to finding the most appropriate linguistic equivalent in the target language, the 'language of the law' seems to defy this principle of the universality of concepts. Metaphorically speaking, the legal language of all states today appears to have been struck by the biblical Tower of Babel effect. Should we dare to presume that the heterogenity of legal systems throughout the world is a living proof that man-made justice can never become a universal concept and that only God's justice embodies this principle? What we can say without any shred of doubt is that the diversity and incongruency of different languages of the law are deeply rooted in the conceptual incongruency of the legal systems in question.1.2 Dealing with conceptual incongruencyThough many legal translators, especially those who lacked proper legal knowledge complained about the difficulty of legal translations due to the inherent incongruecy of legal terminology, legal texts have been translated for centuries. …


The autor studies Cristobal Aguilar's career from human and artistic points of view, because of its importance for Spanish Engraving History at the second half of XX century.


We measured the temperature dependence of resistivity of (TMTTF) 2 SbF 6 under high pressures up to 10 GPa. We observed superconductivity in the title compound for the first time when the high pres...


Lack of information on the molecular structures of receptor proteins hampers the development of an understanding of their mechanisms. Small molecular models have served in the study of discrete details of such mechanisms, but receptor processes like recognition and activation take place in the protein environment of the receptor which may have a role in the process. To learn about the possible role of the protein environment in these mechanisms, we followed a heuristic approach in which models are used that range from small molecular complexes to macromolecular environments that model the receptors. The underlying assumption in such modelling is that similar elements of secondary structure, present in the model proteins as well as in the receptors, will make similar contributions to the molecular mechanism in which they function. We report the results of computational simulations of the activation mechanisms in a model protein environment used to study the effect of the protein structure on the proposed activation mechanism of the H2-receptor of the neurotransmitter histamine. The Protein Data Bank was searched for a protein of known structure that could serve as a model for a macromolecular environment of the histamine H2-receptor, based on a series of requirements defined by findings from our previous work on small molecular complexes modelling recognition and activation mechanisms in that receptor. The enzyme citrate synthase, E.C. 18.104.22.168, was found to contain the structural elements necessary for such a model. The activation mechanism simulated inside this protein consists of two proton transfer steps: one from the receptor to the neurotransmitter and another from it to a different site of the receptor. Quantum chemical methods were used to calculate the energetics of the proton transfers inside the protein structure represented as a collection of point charges and polarizable dipoles included in the Hamiltonian. The energetic contribution from polarization, as well as the interaction of the proton transfer system with the helix dipoles, is found to affect the proton transfer mechanism. The results suggest protein engineering approaches that can be used to modulate receptor activity by specific changes in the protein structure.


We propose an enhancement to the power allocation among multiple beams in our previously reported non-orthogonal access with random beamforming and intra-beam successive interference canceller (SIC) for cellular multiple-input multiple-output (MIMO) downlink. By equally allocating transmission power among multiple beams, the average user throughput within a cell can be enhanced due to the effective use of spatial multiplexing. The throughput of users at the cell edge may be improved by allocating non-equal transmission power among beams since the inter-beam interference is decreased and the received signal power is increased from the viewpoint of the main beam to which most of the transmission power is allocated. Aiming at further enhancement of the system efficiency and cell-edge user experience in our previous non-orthogonal access scheme, we propose coordinated frequency block-dependent inter-beam power allocation and inter-frequency block power allocation based on fractional frequency reuse (FFR) for inter-cell interference coordination. Based on simulation results, we show that the proposed power allocation method effectively enhances the tradeoff between the average and cell-edge user throughput.


This paper presents a rational solution to the problem of the choice of safety road barriers, through valuation of the total costs based on a statistical and probabilistic approach. The necessary parameters are: a) cost of construction and installation of barrier b) yearly number of collisions between vehicle and barrier c) probability of the different velocity ranges d) probability of the different impact angles e) social economical cost of the accidents f) costs of the human injuries g) costs of the damages to the vehicle h) years of useful life and capitalization rate for the roads. Parameter f and g are further divided into heavy and light vehicles. It is concluded that if the characteristics of the cross section and of the barrier are defined, the total and capitalized social-economical cost will be the function of the only independent variable average daily traffic and the percentage of heavy vehicles. An application of the process is given. For the covering abstract of the conference see IRRD 832707.


This study evaluated the effects of group-based credit programs in rural Bangladesh: Grameen Bank Bangladesh Rural Advancement Committee (BRAC) and Bangladesh Rural Development Boards (BRDB) Rural Development RD-12 program. The study determined the impact on childrens nutritional status. The article includes a description of economic theory of household allocation and the estimation and identification of structural equations with covariance restrictions based on regression errors with a factor-analytic structure. Credit programs are expected to improve nutrition by income and substitution effects and by increasing womens role and power in the household resource allocation process. All programs work with the rural poor. Data were obtained from a 1991-92 survey among 1798 households in 87 villages in rural areas. The sample included program recipients and non-program persons who were eligible for the program. The research design eliminated the unobserved who might have biased estimates of the impacts of these programs. The residual includes left-out household and individual level variables. The residual covariance matrix was restricted by nutritional status at two points in time and a factor-analytic structure. Results indicate a large positive statistically significant impact from womens credit programs on two measures of nutritional well-being. Mens credit had no significant impact. A 10% increase in credit provided to females increased the arm circumference of daughters by 6.1% and of sons and increased the height for age for boys and girls. Male or female credit did not affect Body Mass Index.


Objectives: To evaluate corneal changes as measured by Pentacam before and after transepithelial corneal collagen cross-linking in cases of Keratoconus. Study design: A prospective consecutive case series study carried out at a private lasik centre Patients and Methods: 74 eyes of 50 patients with progressive keratoconus underwent transepithelial (Epi-on) CXL using both ParaCelTM and vibeX-Xtra. Baseline examination included: full ocular examination, uncorrected visual acuity (UCVA), best corrected visual acuity (BCVA), corneal topography using PentacamTM to determine; flat corneal curvature (K1), steep corneal curvature (K2), mean corneal curvature (Km), corneal astigmatism, corneal thickness at the thinnest location and posterior surface elevation at the highest point in the central 5 mm. The follow-up visits were scheduled on 3 and 6 months after treatment by checking the BCVA, PentacamTM. Results: Our results showed an improvements in BCVA at the end of the 6th month post operative that showed an increase from 0.48 to 0.54 and this was statistically significant (P value 0.007) (<0.01), Pentacam topographic changes were found to be decreased postoperatively and were found to be statistically insignificant. Conclusion: In this study, with a follow-up for 6 months, we found the transepithelial corneal collagen cross- linking is beneficial and safe for patients with keratoconus. Transepithelial CXL treatment appeared to halt keratoconus progression, with a statistically significant improvement in visual acuity by stabilizing or partially reversing the keratectasia process.


This article analyzes the character of Miller by applying the post-modern social and cultural theory proposed by Fredric James. This article also points out the obvious feature of late Capitalism shown within lines through the depicting and analyzing of the characters. It also reveals the writer of Catch-22's intention of exposing the essence of post-industrial American society and its value to the public by creating the character of Miller.


Concerning batch release in the pharmaceutical industry, the conformity analyses can be time consuming if all of them are performed after the manufacturing process. From this concept is born Process Analytical Technology (PAT) (1): it enables to monitor in real time each critical step of a manufacturing process reducing batch release time. Moreover, thanks to its real time character, PAT gives also the opportunity to tune manufacturing parameters in order to avoid the loss of potential batches. Pellets manufacturing process involves many steps such as blending, granulation, extrusion, spheronization and drying. A real time monitoring system like PAT is then particularly convenient to control such a complex process (2). Thanks to its non invasive, non destructive character and fast data acquisition, near infrared spectroscopy is more and more integrated in the PAT system, especially in the pharmaceutical field (2, 3). The aim of the present study was to develop and finally validate a near infrared model that was able to determine accurately a moisture content ranging from 1 to 8 % in pharmaceutical pellets


A major storm passing over the 21.4 km Agricultural Research Service (ARS) Goodwin Creek experimental research watershed in northern Mississippi on April 23-24, 2001 is used as a case study to highlight uncertainties associated with using hydrological and hydrometeorological data from various remote-sensing and point sources at greatly differing space-time resolution and coverage. Instrumentation of the research watershed includes approximately 45 rain gauges of various designs (above ground and buried), a raindrop spectrometer, and stacked anemometers to observe the wind profile at the climate station in the center of the catchment. A local-scale mobile Doppler radar was also deployed to record very high-resolution precipitation observations (50 m by 1 degree in space, tens of seconds in time) in both the vertical and horizontal directions over the catchment. These data, along with regional-scale lower-resolution observations from the Memphis WSR-88D (KNQA) radar (1 km by 1 degree in space, several minutes in time), are utilized to analyze the storm. The difficulties of obtaining accurate measurements and of merging observations made by point and remote sources are discussed. The basin response to the storm is illustrated with runoff measurements at the basin outlet.


The design of efficient and scalable streaming Content Distribution Networks (CDNs) is an open problem of great economic interest. A key decision is the number of replica servers to use and their location to balance network bandwidth and server costs. This problem is highly complex, since it is interrelated to the streaming media delivery protocols, client redirecting decisions, and the content delivery routing problem. To address this design problem, we develop heuristics for the server placement, the server selection, and the routing problem. In contrast to previous work, we study both periodic broadcast and hierarchical merging protocols using multiple media files with different request rates. The heuristics lead to highly accurate and fast approximations. We also analyze the relationship between the start-up delay caused by some delivery protocols, the bandwidth consumption, and the number of replica servers, providing complete and fully implementable solutions to the design of streaming CDNs.


Background. The aggression outcome expectation is believed to be an important cognitively influencing factor of aggression. Discovering the neural mechanism of aggression outcome expectation is conductive to develop aggression research. However, the neural correlates underlying aggression outcome expectation and its deleterious effect remain elusive. Methods. In this study, we utilized voxel-based morphometry (VBM) to unravel the neural architecture of aggression outcome expectation measured by the Social Emotional Information Processing Assessment for Adults and and its relationship with aggression measured by the Buss Perry Aggression Questionnaire in a sample of 185 university students (114 female; mean age = 19.94 plus/minus 1.62 years; age range: 17-32 years). Results. The results showed a significantly positive correlation between aggression outcome expectation and the regional gray matter volume (GMV) in the right middle temporal gyrus (MTG) (x = 55.5, y = -58.5, z = 1.5; t =3.35; cluster sizes =352, p < 0.05, GRF corrected). Moreover, aggression outcome expectation acted as a mediator underlying the association between the right MTG volume and aggression. Conclusions. These results found the neural correlates of aggression outcome expectation and its effect on aggression for the first time, which may contribute to our understanding of the cognitive neural mechanism of aggression and tentatively provide an effective method to identify potential neurobiological markers for aggression.


The geometric configurations, electronic structures and vibrational frequencies of the (BCO)_n~+(n=1-12) were calculated with B3LYP method at 6-31G* level. The result revealed that the ground states of the clusters favor three- and five-member rings and disfavored four- and six-member rings in the framework, in which all the carbonyls were terminal. Energy analysis exhibited that the (BCO)_n~+ with odd n was more stable than that with even n.


The energy of graph G is defined as the sum of the absolute values of eigenvalues of the adjacency matrix A(G). The manual calculation of energy of graphs consumes several man hours. In this paper, we use MATLAB to generate the Seidel matrix and hence calculate the Seidel energy of some mesh derived networks.


The expression level of RARβ gene was detected by RT-PCR in fibroblast cell through adding different concentration of vitamin C. The result showed that vitamin C could promote the expression of RARβ, moreover different concentration and action time had different results.


To support effective sharing and quick searching of various business components,a description language named Web Ontology Language for Business Component(OWL-BC) based on domain ontology was proposed.Business terminology and business data were extracted from some business standards,and were employed as the norms for defining functional semantics and data semantics of business components to solve heterogeneous semantics problems.Accordingly,in order to meet the requirements of business activities,functional and data semantics matching approaches were jointly used to search for suitable business components.Considering the decomposition and composition of data semantics,a greedy heuristic based on concept-set correlation was proposed to conduct business components composition matching.Efficiency of the algorithm was validated by experiments.


Background The COVID-19 pandemic ushers in a "new" normal, in which digitization implements different ways of working and learning. The aim of the study was to assess the perceived impact of online classes on sophomore nursing students of Santiago City.
Method: In this descriptive cross-sectional study, 118 sophomore nursing students (n=118) were recruited. An online survey questionnaire was the main tool to collect data. Descriptive statistics were employed for data analysis.
Result: The majority of respondents were female (79.66%), and perceived skills and competencies of instructors during online class, weighted in different areas such as instructional skills (M=3.48, SD=1.15), instructional resources (M=3.45, SD=1.15), approaches/techniques (M=3.38, SD=1.18) and evaluation techniques (M=3.37, SD=1.14) which interpreted as satisfactory respectively in all areas. Lastly, the perception of the respondents on the effects of online classes shows a strong agreement on the belief that face-to-face learning is more effective than online learning.
Conclusion: Nowadays, the new normal continues to shape the world. With its use, few students find their lives easier, more convenient, and more comfortable. But most students face a dilemma in utilizing new normal technology in making school requirements which did not help them to be productive.
KEYWORDS: Online Class, Academic Performance


A 3-year-old crossbred cat was presented at the clinics. History revealed that the cat had sustained frequent straining for the last 12 hrs. One kitten was found stuck in the birth canal. The cat was premedicated with atropine sulphate @ 0.04 mg/kg b.wt and tranquilized with acepromazine maleate @ 0.1mg/kg b.wt. I/M, and anesthetized with propofol @ 4 mg/kg b.wt. I/V. via the cephalic vein. The abdominal region was aseptically prepared from the umbilicus to the pubis region. A ventral mid line incision of approximately 3.5 cm was made in linea alba between the umbilicus and pubis, caudally. The gravid uterus was exposed through the surgical wound. A longitudinal incision was placed on the uterine body and kittens were taken out slowly one by one. One of the kittens, which was stuck in the vaginal orifice, was taken out slowly by gently manipulating its presentation. A total of four kittens were born. The use of acepromazine and propofol anesthesia for the cesarean section in the cat proved to be an easy and excellent method without any complications.