STUDIES WERE CONDUCTED ON THE EFFECTS OF VIBRATION ON ASPHALT SURFACINGS IN GERMANY. THESE STUDIES SHOWED THAT: (1) VIBRATING ROLLERS WITH A WEIGHT OF ABOUT FOUR TONS PRODUCED MARKEDLY BETTER COMPACTION THAN A 10-TON STATIC ROLLER, (2) PROLONGED VIBRATION DID NOT CAUSE ANY SEGREGATION IN A WELL-PROPORTIONED ASPHALT MIX, (3) WHEN THE ASPHALT MIX WAS PROPERLY PROPORTIONED, THE TOP SURFACE HAD THE SAME APPEARANCE AFTER STATIC ROLLING AND VIBRATION, AND (4) COMPARATIVE MEASUREMENTS OF THE EVENNESS OF THE ASPHALT SURFACINGS GAVE VERY SIMILAR RESULTS FOR STATIC ROLLING AND VIBRATION. SWEDISH INVESTIGATIONS OF VIBRATION EFFECT ON ASPHALT SURFACINGS RESULTED IN THE DESIGN OF A NEW 1.7-TON VIBRATING TANDEM ROLLER. THE DEMAND FOR MORE SURFACE CAPACITY LED TO THE DEVELOPMENT OF A LARGER VIBRATING TANDEM ROLLER WITH A DRUM WIDTH OF 1.5 METERS. THESE ROLLERS ARE BEING USED FOR COMPACTING EMBANKMENTS, SUB-BASES, BASES OF CRUSHED ROCK AND BITUMEN-STABILIZED GRAVEL AS WELL AS ASPHALT SURFACINGS. VIBRATION OF ASPHALT PAVEMENTS HAS THE ADVANTAGE THAT EFFICIENT COMPACTION CAN BE ACHIEVED EVEN AT COMPARATIVELY LOW MIX TEMPERATURES. VERY GOOD COMPACTION AND CLOSING EFFECT CAN BE OBTAINED AT JOINTS BETWEEN DIFFERENT STRIPS. ON DEEP-LIFT ASPHALT LAYERS, THE NEW ROLLER WILL HAVE SPECIAL ADVANTAGES THROUGH ITS EFFECT-IN-DEPTH.


This paper introduces the program of once-through demolition of 10 buildings blasting demolition. Some useful ideas, such as special structures' earlier blasting disposal in a building, low blasting kerf to controlling the collapsing area and effective protecting techniques are adopted, which can be referred to the similar project.


Sorghum is used as a source of energy alternative to corn, however, its low pigments content are considered hindrance to the use of this feedstuff for poultry. The inclusion of annatto seed by-product (ASB) may solve this problem. In this context, the objective of this study was to evaluate the effect of ASB inclusion in diets containing sorghum as the main source of energy on performance, carcass traits, meat color, and economic viability in the production of slow-growth broilers. A total of 420 sexed chicks of the Carijo Pesadao line were distributed in a completely randomized design according to a 2 × 7 factorial arrangement, with three replicates of 10 birds per treatment. Studied factors were two sexes (males and females) and seven diets, wherein one had corn as source of energy and the others contained sorghum plus inclusion of 0, 3, 6, 9, 12, and 15% of ASB. Irrespective of the sex, diets did not affect feed intake (g/bird), feed conversion (g/g), yields (%) of carcass, breast and drumstick+thigh, percentage of abdominal fat, or relative weight of the liver. However, the inclusion of ASB influenced the color parameters of the meat making it more pigmented and improved the economic viability parameters. In diets for slow-growth birds containing sorghum as the main source of energy, ASB can be included up to 15%, and meat pigmentation problems can be reduced with total substitution of corn by sorghum with inclusion of ASB from 3%.


EDITOR—We agree with Jonathan Gillis about the guidelines of the Royal College of Paediatrics and Child Health on withholding or withdrawing life saving treatment in children. 1 2 There is little doubt about the need for such a document. Modern treatment has made it possible to prolong life beyond the point where continued treatment is physiologically futile and the benefits of living might be …


AbstractAn agricultural waste, sawdust was modified into magnetic nanoadsorbent (Fe3O4-SD) and used for single and bicomponent removal of Cu(II) and Ni(II) ions from aqueous solution. Adsorbent particles were characterized through XRD, TEM, FTIR, vibrating sample magnetometer, and Brunauer–Emmett–Teller analysis. The effect of initial metal concentration, contact time, adsorbent dose, pH, and temperature was studied within a suitable range. A contact time of 90 min was needed for equilibrium to be established. Adsorption of Cu(II) and Ni(II) ions onto Fe3O4-SD decreased with increase in temperature showing exothermicity. Process was found to be thermodynamically favorable and spontaneous and physical in nature. Equilibrium data fitted well with Langmuir isotherm model and followed pseudo-second-order kinetics. Adsorption capacity achieved was less when Cu(II) and Ni(II) coexisted in the solution in comparison with when they acted independently, thus supporting antagonistic behavior. Technical feasibility ...


100 records were chosen of men who had undergone a vasectomy at Caminer House Clinic of the Family Planning Association of Australia in Sydney. The average age of the male was 37.43 years; wives averaged 33.96 years. Patients were married for an average of 12 years and averaged 3 children. The average rank status of this group showed them to be from the lower socio-economic level.


We model transient copolarized degenerate four-wave mixing in a saturable gain medium, using pulses of duration much shorter than the population lifetime with a finite probe beam. Initially we describe a model to include the simultaneous existence of both the reflection and transmission gratings for arbitrary field strengths. Then we develop a model to include all four possible gratings, including standing-wave gratings between counterpropagating pump beams and the probe and conjugate beams. By use of two expansion methods for the higher-order grating terms it is possible to model regimes in which either one grating is arbitrarily strong or all four gratings are strong. Comparisons are made among models including one, two, and four gratings. Good agreement is found between the theoretical four-grating case and pulsed copolarized degenerate four-wave mixing experiments in laser-pumped Ti:sapphire for a finite probe beam.


Learn to recognize the many faces of this baffling disorder, then teach your patient ways to maintain her health and prevent symptom flares.


BACKGROUND
Congenital intestinal lymphangiectasia is a rare disease in childhood, which may already cause protein-losing enteropathy in newborns.

PATIENT, METHODS AND RESULTS
This is a case report of an infant with generalized edema and protein-losing enteropathy, in whom intestinal lymphangiectasia was diagnosed at the age of two months. Following repetitive intravenous albumin und gamma globulin infusions, the elimination of long-chain fats from the diet and the substitution with medium-chain triglycerides (MCT) led to an improvement of the protein-losing enteropathy.

CONCLUSION
In newborns with low level of serum protein and edema protein-losing enteropathy caused by congenital lymphangiectasia might be considered as a differential diagnosis.


Confirming the identity of the remote Internet Protocol enabled device, managing the speed of the data stream to the remote Internet Protocol enabled device based on the identified identity, and using the broadband network to Systems, methods, and computer-readable media for remote access to internet protocol television by enabling placeshift using a telephone company network comprising sending a data stream to an internet protocol enabled device .


Abstract : The credibility of U.S. Armed Forces in the future may well depend on how they perform during peace enforcement operations. This implies that rules of engagement (ROE) for peace enforcement operations must be carefully written to provide maximum protection to U.S. Forces and to prevent excessive use of force in order to maintain public and political support. On 22 December 1994, after Operation Restore Hope and during Operation Uphold Democracy, the Chairman of the Joint Chiefs of Staff (CJCS) published the SROE. The SROE, which superseded the Joint Chiefs of Staff Peacetime ROE (PROE), became the current basis for drafting operation-specific ROE. This paper reviews the PROE process used in Operation Restore Hope and Operation Uphold Democracy; identifies the problems which occurred and how they were solved; demonstrates that the new SROE would neither have prevented nor solved these problems more easily; and concludes with recommendations for improving the SROE process for future peace enforcement operations.


In this study, wave forces of tsunami on simplified onshore buildings at Penang Island were investigated. Single-storey and double-storey buildings were downscaled at a ratio of 1:100 and subjected to tsunami bores of various runup heights in a 1 m x 1 m with 40 m long wave flume. Tsunami wave height and velocity at the location of building model were obtained. The experimental results revealed that the nature of wave attack on building model depends on the relationship between model height and nominal height of the wave. The time histories of forces in the horizontal and vertical direction and pressures on buildings due to simulated tsunami-like waves were measured. The relationships among the forces and pressures for the incident wave with nominal wave height around 40 mm were discussed in detail. It is observed that the maximum horizontal force and front pressure were attained when nominal height of the wave was achieved by the flow. The experimental results provide useful information for the dynamic analysis in the later stage of the study.


A study was made of the erosion of blades of pitched blade impellers in a suspension of solid particles in a liquid under a turbulent regime of flow of an agitated charge. The wear of the impeller is described by an analytical approximation in exponential form, and the influence of the pitch angle on the impeller blade wear was studied experimentally. It follows from the results of the experiments made that the wear rate of the pitched blade impellers increases linearly with the decreasing pitch angle within the interval a I a15°; 45° n. The proposed form of radial profile of the leading edge of the impeller blade enables us to calculate the surface of the worn blade. This quantity significantly decreases with the length of the period when the blades are affected by the solid particles, and its values calculated according to the suggested profile of the worn blade fit fairly well with the experimentally determined values. The results of the experiments performed are valid for homogeneous distribution of solid particles in an agitated suspension.


The effect of chain architecture on the morphological and tensile properties of series of multigraft copolymers, with regularly spaced tri-, tetra-, and hexafunctional junction points, was investigated using transmission electron microscopy (TEM), small-angle X-ray scattering (SAXS), and tensile testing. The materials were synthesized by coupling difunctional polyisoprene (PI) spacers and living polystyrene (PS) branches, made by anionic polymerization, with chlorosilanes of different functionalities. Since the coupling process is a step-growth polymerization, yielding polydisperse products, fractionation was utilized to separate each material into three fractions (high, middle, and low molecular weight), each of low polydispersity. All three fractions have the same chain architecture on a per junction point basis but differ in the number of junction point units per molecule. By applying the constituting block copolymer concept, the physical behavior of these molecules was compared with current theories. ...


Abstract : An approximate mathematical model for free vibrations of the Class II Flextensional underwater acoustic transducer shell is presented. The energy expressions and equations of motion for symmetric modes of vibration of the shell are developed in detail. (Author)


With the development of drone technology, quadrotor transportation has become an important application direction. Most of the control designs for a quadrotor with a cable-suspended payload (QCSP) are aimed at fixed cable lengths, but there are few controller designs for varying cable length QCSP with broad application prospects. In this paper, a controller for varying cable length QCSP is designed using parameter adaptive multi-layer sliding mode structure to control the payload swing, quadrotor position tracking and single-layer sliding mode structure to control the cable length of the suspension system. The nonlinear coupling problem in the QCSP is solved by a simple method, avoiding tedious design reasoning and parameter ad-justment. Simulation experiments were conducted and compared with traditional PD controllers, proving the effectiveness of this method in suppressing load swing angles of varying cable length QCSP.


Hemin, the oxidized form of heme, is released from hemoglobin after CNS hemorrhage and may contribute to injury to surrounding tissue. The heme oxygenase (HO) enzymes catalyze the breakdown of hemin to biliverdin, carbon monoxide, and ferric iron. Although HO‐2, the isoform expressed predominantly in neurons, accelerates heme‐mediated neuronal injury, inhibitor studies suggest that HO‐1 induction has a protective effect on astrocytes. In the present study, we directly compared the vulnerability of cultured HO‐1 knockout and wild‐type astrocytes to hemin. Consistent with prior observations, exposure of wild‐type cultures to hemin for 24 hr resulted in protein carbonylation and concentration‐dependent cell death between 10 and 60 μM, as determined by MTT and lactate dehydrogenase release assays. In cultures prepared from mice lacking the HO‐1 gene, oxidative cell injury was approximately doubled. Both protein oxidation and cell death in HO‐1 knockout astrocytes were significantly reduced by pretreating cultures with an adenovirus encoding the HO‐1 gene prior to hemin exposure. HO‐2 expression was observed in both knockout and wild‐type cultures and was not altered by HO‐1 gene deletion. Cell hemin accumulation after 20 hr hemin exposure was 4.7‐fold higher in knockout cells. These results support the hypothesis that HO‐1 protects astrocytes from heme‐mediated oxidative injury. Selectively increasing its expression in astrocytes may be beneficial after hemorrhagic CNS injuries. © 2005 Wiley‐Liss, Inc.


AMONG the theological concepts which we find in St Paul's writings, that of pleroma occupies comparatively little space, if we judge by quantity. The word occurs only about a dozen times in his epistles,' and has a specifically theological significance only in Ephesians and Colossians. Yet it is one of the richest and most suggestive of his notions. A closer examination of it reveals interesting relationships with other Pauline doctrines: it throws light on the whole network of Paul's soteriology and ecclesiology; it suggests a fuller understanding of his Trinitarian doctrine. It also raises problems: what are its sources and literary origins? what is its place in the development of Judreo-Christian thought? is the idea of pleroma tenable in modern civilization? The intention of this article is a modest one: I wish simply to outline the main points of inquiry that ought to be raised in connection with the problem and to suggest possible solutions, in the hope that these will be relevant to contemporary Christian life and thought.


This paper presents an overview of some of the most enjoyable low-temperature plasma experiments I have carried out with my students over the course of my career. It begins with the connection between solitons and the Schrödinger equation, and continues with the discovery of cylindrical solitons. From moving structures, we progress to stable ones: sheaths and double layers. How can we measure double-layer potentials? This question leads to the development of emissive probe techniques. From there, we move on to the Bohm criterion and the first measurements of the full plasma potential variations of sheaths and presheaths in a single-species plasma, and later in two-ion-species plasmas. Finally, our recent measurements of double layers and presheaths in uniform helicon plasma are presented.


To the Editor: The prevalence of anti-glutamic acid decarboxylase (GADAb) and anti-thyroperoxidase (TPOAb) autoantibodies in relatives of diabetic patients has been investigated, but most studies have been conducted on patients with type 1 diabetes mellitus (T1DM) diagnosed during childhood or adolescence and little is known about relatives of patients with adultonset T1DM or latent autoimmune diabetes of the adult (LADA). Recently, Dagdelen et al. (1) have shown a higher frequency of GADAb and TPOAb in relatives of adults with T1DM (age at diagnosis: 18–35 years) compared with a non-diabetic control group and familial aggregation of TPOAb positivity. Adding to the results of that study (1), we report the frequency of GADAb and TPOAb in siblings of adult patients with T1DM, LADA and T2DM observed at our service. A total of 239 siblings of 153 patients with diabetes diagnosed at 35 years of age or older were studied. Patients without ketoacidosis or symptomatic hyperglycaemia who did not require insulin at diagnosis and for at least 1 year thereafter were classified as T2DM when GADAb was negative (54 patients and 84 siblings), or as LADA when GADAb was positive (54 patients and 80 siblings). The presence of ketoacidosis or symptomatic hyperglycaemia and the requirement of insulin at diagnosis or immediately thereafter, associated with GADAb positivity, was defined as T1DM (45 patients and 75 siblings). The characteristics of the 153 patients have been published previously (2,3) and those of the 239 siblings are shown in Table 1. Patients and siblings were submitted to laboratory assessment (GADAb and TPOAb) with < 2 years since the diagnosis of diabetes in the former. The frequency of GADAb was significantly higher in siblings of patients with T1DM and LADA than in siblings of patients with T2DM (p < 0.001). Regarding TPOAb, a difference was only observed between subjects whose diabetic siblings were TPOAb positive (Table 1). Our results agree with those reported by Dagdelen et al. (1) in terms of the higher frequency of GADAb in relatives of adult patients with T1DM (here compared with siblings of patients with T2DM), emphasising that in that study (1) age at the time of diagnosis of diabetes ranged form 18 to 35 years and was ‡ 35 years in the present investigation; however, the mean age of the relatives was similar in the two studies. In addition, we extended this finding to LADA. A higher frequency of TPOAb (approximately 20%) was observed in the subgroups of siblings of patients with T1DM or LADA who were TPOAb positive, a finding previously reported for children with T1DM (4) and in agreement with the familial aggregation demonstrated by Dagdelen et al. (1).


With the rapid expansion of network scale and the continuous evolution of network applications, the Internet becomes much more open and uncontrollable, and inevitably faces a variety of security threats. In order to satisfy the requirements of the current Internet security and transmission performance, the general solution is increasing specific devices (e.g., firewalls, network monitors) to detect and defend against attacks. However, these devices typically use a dedicated hardware-based or software-based architecture which is closed, leading to limited scalability, management complexity. And deploying a new application needs to develop new equipment, which take a long development cycle and costs a lot.In this paper, we introduce an innovative Dynamically Enable Function In Network Equipment (DEFINE) to allow tenant get the network service quickly. First, DEFINE decouples an application into different functional components, and connects these function components in a reconfigurable method. Second, DEFINE provides a programmable interface to the third party, who can develop their own processing modules according to their own needs. To verify the effectiveness of this model, we set up an evaluating network with a FPGA-based OpenFlow switch prototype, and deployed several applications on it. Our results show that DEFINE has excellent flexibility and performance.


Supplemental Digital Content is available in the text. Fibromuscular dysplasia (FMD), regarded as a generalized vascular disease, may affect all vascular beds and may result in arterial stenosis, occlusion, aneurysm, or dissection. It has been proposed to systematically evaluate all vascular beds in patients with FMD, regardless of initial FMD involvement. However, the impact of this approach on clinical decisions and on management is unknown. Within the prospective ARCADIA-POL study (Assessment of Renal and Cervical Artery Dysplasia–Poland), we evaluated 232 patients with FMD lesions confirmed in at least one vascular bed, out of 343 patients included in the registry. All patients underwent a detailed clinical evaluation including computed tomography angiography of intracranial and cervical arteries, as well as computed tomography angiography of the abdominal aorta, its branches, and upper and lower extremity arteries. In the study group, FMD lesions were most frequently found in renal arteries (87.5%). FMD was also found in cerebrovascular (24.6%), mesenteric (13.8%), and upper (3.0%) and lower extremity (9.9 %) arteries. Newly diagnosed FMD lesions were found in 34.1% of the patients, and previously undetected vascular complications were found in 25% of the patients. Among all FMD patients included in the study, one out of every 4 evaluated patients qualified for interventional treatment due to newly diagnosed FMD lesions or vascular complications. The ARCADIA-POL study shows for the first time that the systematic and multidisciplinary evaluation of patients with FMD based on a whole-body computed tomography angiography scan has an impact on their clinical management. This proved the necessity of the systematic evaluation of all vascular beds in patients with FMD, regardless of initial FMD involvement.


The initial screening decision that marketing managers make is critical. It requires the selection of which innovation project to invest in, which is fundamental to marketing success. However, our knowledge of how managers make these decisions and how this impacts performance is limited. By drawing upon cognitive psychology and the managerial decision-making literature, we address two critical questions. The first question focuses on identifying specific decisionmaking types (e.g., specific heuristics, intuition) used when making an innovation-screening decision. Based on this analysis and prior research, we develop specific decision-maker profiles about how an individual manager decides. The second research question is about connecting these profiles with performance. Specifically, it addresses what the consequences of different decision-maker profiles are on the perceived accuracy and speed of decision-making? Data were collected from 122 senior managers in these industries. We find that when heuristics are used alone, or concurrently with intuition, managers make decisions that are as accurate as when they rely on analytical decision-making. However, the process is significantly faster. The findings provide an important step towards a more comprehensive understanding of decisionmaking at the front-end of innovation.


Properties of the solar/stellar winds are discussed and applied to the effects of the winds on motion of dust particles in the Solar system and around stars. As for the secular orbital evolution of the spherical interplanetary dust particles, the solar electromagnetic radiation is 1.5-times more important than the solar corpuscular radiation, the solar wind. The relevant contributions of the solar wind action contain also the sputtering and reflection components in addition to direct impact. The importance of the wind can be partially increased by considering the decrease of dust particle mass due to the wind bombardment, and, mainly, due to the non-radial component of the solar wind velocity. Time dependence of the solar wind properties plays a less important role. The presented equation of motion of a dust particle under the action of the solar radiation respects reality in a much better way than the conventionally used equation. The dimensionless cross-section the dust grain presents to wind pressure is about 9/4. This value differs from the conventionally used value 1.0. The mass-loss rate of the zodiacal cloud is (7/3)-times higher than the currently accepted value, as for the micron-sized dust particles.


Fundamentally, one can equate radio, television and print as being technically different versions of broadcast communications. They use different channels and have different descriptive modes, but they all follow a one-to-many paradigm. Powerful local computing and storage can change this, transforming a broadcast into a dialogue, a presentation into a conversation. This is a basic change in the notion of publication, with technical and intellectual ramifications. This paper will describe two ongoing research projects that address the evolution of publishing brought about by large-scale personal optical storage. In each, read-only and read/write analogue devices are used to jointly and simultaneously store images and related data, permitting distribution of a superset of information in compact, machine readable form. The significance of the work is that optical storage is integrated into the more general storage heirarchy of the computer as opposed to being a flexible peripheral.


Image convolution similar to the receptive fields found in mammalian visual pathways has long been used in conventional image processing in the form of Gabor masks. However, no VLSI implementation of parallel, multi-layered pulsed processing has been brought forward which would emulate this property. We present a technical realization of such a pulsed image processing scheme. The discussed IC also serves as a general testbed for VLSI-based pulsed information processing, which is of interest especially with regard to the robustness of representing an analog signal in the phase or duration of a pulsed, quasi-digital signal, as well as the possibility of direct digital manipulation of such an analog signal. The network connectivity and processing properties are reconfigurable so as to allow adaptation to various processing tasks. Keywords—Neural image processing, pulse computation application, pulsed Gabor convolution, VLSI pulse routing.


The influence of the accuracy of tests in the process of quality control is analyzed on the example of assessing the class of concrete in standard samples and non-destructive methods. Quality control is seen as part of the reliability triad, ensuring a level of reliability during construction. The relationship was established between the accuracy of test methods and quality control based on the result of construction. The factors influencing the efficiency increase of the quality control system are determined The prospects for the development of the accuracy of standard destructive and non-destructive testing methods are assessed. A system for evaluating and monitoring the effectiveness of testing by non-destructive methods and a connection with the reliability of the structures being erected has been developed; A rational organization of concrete strength control using direct and indirect methods is proposed. The calculation of the organizational and technical potential for the use of non-destructive testing methods has been made; assessment of the influence of changes in the structural characteristics of concrete during its long-term operation on the results of non-destructive testing of strength.


Purpose
The accounting system plays an important role in the company's organizational structure. The purpose of this paper is to demonstrate that the integration of management accounting practices is subject to coordination between external and internal factors and accounting management practices.

Design/methodology/approach
Therefore, the authors move to the contingency model to determine the most significant external "unexpected factors" that explain the introduction of management practices for the management of the various stages of development. The exploratory study examines a sample of Pakistani companies from various sectors.

Findings
This study reveals that the main factors of uncertainty that affect the organizational structure, environmental uncertainty, advanced production technology, just-in-time method strategy, integrated management of quality and structure findings reveal that MAP affected all process and changes all system in simple to complex system in Pakistani's industries.

Practical implications
This study is to acquisition the impact of external factors on management accounting practices, to find the impact of internal factors on management accounting practices, to establish the management accounting practices undertaken by the companies in Pakistan.

Originality/value
The study contributes to the literature by enhancing our understanding for the impact of external and internal factors on management accounting practices in Pakistan.


An activated sludge process using membrane units for solidliuqid separation was investigated. This system achieved more than 95% of COD removal under the large variation of experimental conditions, such as organic loading, composition of influent organic materials and the pore size of used membranes. Large molecular organic matters were accumulated in the supernatant of mixed liquor in the aeration tank: the molecular weight of the accumulated substances was estimated more than 100,000 by gelchromatogram. The compositions of effluent from different pore size membranes were almost the same. The filtration rate through membranes increased as the pore size increased in the range of molecular weight cutoff between 10,000 and 300,000 of ultrafiltration membranes. However, the filtration rate did not change with changes in the pore size over that range and dropped sharply beyond the limit va lue of the pore size which was estimated between 1 um and 10 um because of the clogging inside the membranes. KEYWORDS; membrane separation, activated sludge process, wastewater treatment, ultrafiltration, microfiltration


1147 Objectives: Rolipram is a selective inhibitor of phosphodiesterase 4 (PDE4), the enzyme that catabolizes the second messenger cAMP. The enzyme activity of PDE4 is regulated by phosphorylation with greater activity in the phosphorylated than the non-phosphorylated form. Studies using recombinant DNAs showed the phosphorylated form is more sensitive to inhibition by rolipram. Thus, rolipram binding may provide indirect measurement of the activity of PDE4. Methods: In vivo Bmax and Kd were measured by estimating specifically bound (B) and free (F) (R)-[C-11]rolipram under transient equilibrium in PET experiments without blocking (n=5, mass dose: 0.75±0.12 μg/kg), partially (n=5, 0.015–0.0015 mg/kg) and fully blocking (n=2, 0.9–1.0 mg/kg) with non-radiolabeled (R)-rolipram. PET images were acquired with the ATLAS, and metabolite-corrected arterial input function was measured in all scans. B under transient equilibrium was estimated by performing two-compartmental fitting by constraining K1/k2 to the value obtained in full blocking scans. F was estimated from the activity in nondisplaceable compartment and plasma free fraction. Bmax and Kd were calculated by nonlinear fitting using one- and two-binding site models for the saturation curve created from B and F obtained above. At the end of the baseline scans, animals were sacrificed and samples were obtained to measure Bmax and Kd by homogenate binding. Results: Nonlinear fitting provided excellent fitting for the in vivo saturation curves with R2>0.90 for both one and two binding site models. F-test did not show a significant difference in goodness-of-fit between these models not supporting the presence of two binding sites. In vivo and in vitro measurements showed similar Bmax. Kd measured in vivo tended to be smaller than in vitro values. Conclusions: (R)-rolipram has greater affinity in vivo implying greater levels of PDE4 phosphorylation. Research Support (if any): NIMH Z01-MH-002795-04


This paper presents the analysis effect of etching temperature and KOH concentration on convex corner undercutting of (MEMS) accelerometer structure. The Intellisuite CAD simulation software was used for the simulation analysis. From the analysis it was found that the optimum etching condition for this convex corner was at 25 wt% KOH concentration and 63 °C etching temperature. Different types of compensation mask corners were designed which are corner, square and triangle in order to study the undercutting phenomena. In this case, the square corner compensation mask was chosen as it shown the most suitable compensation mask for this design of accelerometer. The etching simulation was continued with square corner compensation mask etched in the optimized temperature and KOH concentration and it indicated that the square corner compensation mask is the most suitable mask to solve the convex corner undercutting for this accelerometer structure.


Multiplex urine‐based assay emerged outperforms single biomarker (e.g., prostate‐specific antigen, PSA) for predicting prostate cancer (CaP), whereas its combined mode has to be fully optimized. Our aim is to determine whether a strategy of combining gene‐based, protein‐based, metabolite‐based with positive, negative makers in urine could optimize a multiplex model for detecting CaP.


The technology to register the multi-temporal spaceborne SAR image is presented.Manual coarse registration is executed to solve the rotation and scale problem first,and then homologous feature points in the images are detected by feature point detector and image matching.The irregular triangle network is constructed based on homologous points and fine registration is realized.Several couples of spaceborne SAR images are fine registered by the technology and accurate checking shows that the registration achieves good effect and the accuracy reaches less than one pixel.


In this paper we illustrate the application of an alternative of the Optimal Homotopy Asymptotic Method (OHAM) to nonlinear generalized van der Pol oscillator. The obtained results proved a very fast convergence and validate this approach, which is found to be reliable and easy to use. Two numerical examples are developed in order to emphasize the accuracy and efficiency of the proposed approach.


sequent removals of tribes across the Mississippi were to be accomplished, often with severe hardship and loss of life. The experiences of the Creeks and particularly of the Cherokees in this removal are fairly well known; the author adds in some detail the story of the Winnebagos, who, in less than forty years, were forced to cede land in seven different negotiations, involving six possible changes of residence. That any tribal organization could survive in the face of such dislocations is remarkable. Yet tribal organization did remain, through the abortive search for an Indian messiah, through the futile attempts to convert the tribes to sedentary farming, and even through the Dawes Severalty Act of 1887 which attempted to divide tribal collective ownership of land into individual holdings. The author sees a new concern for the Indian with the publication of the Meriam Report of 1928, in the Hoover administration, and particularly under Roosevelt when John Collier served as Commissioner of Indian Affairs. World War II, with its conscription of Indians and with its opportunities for off-reservation employment, did much to bring the Indian more closely into American life. Since that time the relations between the two groups have been marked by national pressure, now relaxing to some extent, to bring about the termination of tribal existence.


Optimally doped ceramic superconductors (cuprates, pnictides, ...) exhibit transition temperatures Tc much larger than strongly coupled metallic superconductors like Pb (Tc= 7.2K, Eg/kTc = 4.5), and exhibit many universal features that appear to contradict the BCS theory of superconductivity based on attractive electron-phonon pairing interactions. Here I argue that this paradoxical simplicity is plausibly resolved within the framework of the Pauling-Phillips self-organized, hard-wired dopant network model of ceramic superconductors, which has previously explained many features of the normal-state transport properties of these materials and successfully predicted strict lowest upper bounds for Tc in the cuprate and pnictide families.


The binding of 3H-labeled L-quinuclidinylbenzilate (QNB) sites was studied in cryosections of the rat spinal cord (cervical, thoracic and lumbar cords) by in vitro macroautoradiography in an attempt to elucidate the distribution of muscarinic cholinergic (mACh) receptors. In this study, transverse sections as well as longitudinal sections of the thoracic cord were employed. A moderately high density of QNB binding sites could be seen in the gray matter of the spinal cord, especially in the marginal regions of the dorsal horn and around motor neurons in the ventral horn. In the lateral horn of the thoracic cord, a moderately high density of QNB binding sites was segmentally observed. By image analysis with a RAS 1000 (Amersham), color coded autoradiographic images which enhanced the small differences in optical density could be easily obtained, and quantitative analysis of the QNB binding sites in small-sized regions of the spinal cord was also performed. The highest densities of mACh receptors in the spinal cord were localized in the substantia gelatinosa of the dorsal horn and the region of motor neurons of the ventral horn. These findings suggest that while mACh receptors are related with motor functions, they are deeply related with sensory and autonomic functions.


Background. Congestion at health facilities poses the risk of extensive spread of the severe acute respiratory syndrome coronavirus 2 (SARSCoV-2) to patients at high risk for severe illness and death due to this infection. During the lockdown to control the spread of the virus, many patients with chronic conditions are not visiting health facilities and not collecting their chronic medication. To improve adherence to medication, home delivery of medication was instituted for patients with chronic diseases who had been receiving care at the Skinner Street Clinic in Tshwane. Objective. To support patients with chronic diseases who were unable to collect their medication, by remotely consulting (telehealth) and delivering their medication during the lockdown due to the COVID-19 pandemic. Methods. Patients were identified for potential home delivery of medication from the clinic appointment book. Their files were retrieved, and they were telephoned and offered the option of receiving medication through home delivery instead of attending a health facility. For those who qualified and accepted home delivery, files were sent to the clinic pharmacy. Medication parcels were prepared and sent to ward-based outreach teams to deliver to patients. Relevant information was captured on the Qualtrics platform. Results. A total of 1 727 files were evaluated. Of these patients, 60% were on treatment for HIV infection, and 19% for hypertension. A total of 32% ( n =547) were eligible for home delivery of medication, but only 25% of the 1727 patients accepted the home delivery of medication. Almost 25% could not be contacted. Compared with those with non-communicable diseases (NCDs) or a combination of HIV and one or more NCDs, a higher proportion of HIV-positive patients with no other diagnosis chose not to have their medication delivered at home. Patients using the service expressed their appreciation and requested that it be extended to others. Conclusion. Home delivery of medication has significant advantages for patients. It can ensure that patients continue to adhere to their chronic medication in the midst of the COVID-19 epidemic, without increasing their risk of contracting the virus. Expanding the home delivery of medication to more facilities while aligning it with the Centralised Chronic Medicine Dispensing and Distribution programme has the potential to alleviate the congestion and workload of primary care facilities while these are under severe pressure owing to the COVID-19 pandemic.


Even if the main disadvantage of quantum key distribution algorithms present the final key is the small size compared to the initial size of the transmitted key, the focus is on getting a unique secret keys with a satisfactory size.The final key, obtained with any of quantum key distribution scheme can be used together with one-time pad algorithm to create a perfectly safe cryptosystem.


Author(s): Gadjev, Ivan | Advisor(s): Rosenzweig, James | Abstract: Modern X-ray light sources generate synchrotron radiation from relativistic free electronspassing through magnet arrays such as undulators. The frequency of the radiation scalesquadratically with the energy of the electrons. Conventional RF accelerators have limitedaccelerating gradients that make reaching electron energies capable of producing hardX-rays a dicult engineering demand that requires hundreds of meters of linac sections.Next generation light sources aim to compactify the current sources by employing highgradient advanced accelerators and very short period undulators. Small footprint, narrowbandwidth X-ray sources can have a large impact on X-ray science and its applicationsranging from the medical eld to material science to the interrogation of the nuclearstructure of matter. In this dissertation, two approaches to the scaling down of X-raysources are taken up. The performance of a free electron laser (FEL) based on sub-mmperiod undulators is studied on theoretical grounds. The experimental realization of anall-optical scheme is demonstrated. The output electron beam of an inverse free electronlaser (IFEL) accelerator, driven by a terawatt CO2 laser, is fed into an inverse Comptonscattering (ICS) collision with a retro-reflected CO2 laser pulse


Introduction: Peritoneal dialysis (PD) remains underutilised in the West. The proportion of patients in the UK starting renal replacement therapy (RRT) with PD fell from 7.2% in 2011 to 6.0% in 2016. At our centre, 8.4% of dialysis patients received PD in April 2014. Evidence suggests that home dialysis improves patient clinical outcomes; therefore, a target was agreed to achieve 25% of dialysis patients receiving PD by 2018. Methods: A rapid improvement process was introduced, as a quality improvement tool, to increase and sustain the PD programme. With multidisciplinary team support for PD growth, a nephrologist was trained to insert PD catheters. Nurses were trained to provide patients with balanced pre-dialysis information and discuss alternative dialysis modalities with haemodialysis (HD) patients. The "Acceptance, Choice and Empowerment" project raised awareness of home therapy choices, using a peer educator model specifically for ethnic minority patients. Lean methodologies were used to ensure continuous quality improvement. Results: PD uptake increased from 37 to 84 patients, giving a PD penetration increase from 8.4% to 19.1% between April 2014 and March 2018. Catheter insertions increased from 94 at the end of QI Period 1 to 185 at the end of QI Period 2, representing a 97% increase, with the medical/surgical split remaining stable. Peritonitis rates remained stable, and PD drop off to HD reduced from 52% to 41% during the same period. Conclusions: By implementing a rapid improvement process and embedding a quality improvement programme, the number of incidents and prevalent PD patients increased and was sustained.


Introduction. The cognitive processes that underpin successful mathematical processing in children have been well researched by experimental psychologists, but are not widely understood among teachers of primary mathematics. This is a shame, as an understanding of these cognitive processes could be highly useful to practitioners. This paper focuses on 'working memory', a cognitive system responsible for the concurrent storage and processing of information, which has been shown to be highly important in children's mathematical processing. Method. This paper describes two experiments, both using a correlational design, undertaken with groups of 9 and 10 year old children. The first experiment compared performance on all elements of the Baddeley and Hitch working memory model with performance on simple addition and multiplication. The second experiment developed the first by taking a more detailed look at central executive functioning and comparing it with performance on addition and multiplication. Both experiments also looked at the children's predominant calculation strategy to see if there was any evidence that working memory performance affects strategy development. Results. Results from the first experiment suggested that addition and multiplication make different cognitve demands on children, with multiplication drawing more heavily on phonological working memory and addition drawing more heavily on executive processes. The second experiment suggests that the involvement of executive processes in multiplication may be in inhibiting incorrect answers, whereas in addition they are linked to the ability to maintain and process information concurrently. Discussion and Conclusion: The results are discssed in terms of their usefulness for classroom practitioners.


Abstract Sodium alginate was provided with good processibility according to physical and chemical characterization of itself. Alginate scaffold has been used for preparation of soft or hard tissue engineering, but the structure of the scaffold needs to be improved for better performance for skin tissue engineering. In this study, highly porous alginate membrane was formed with ionic crosslinking. High molecular weight (Mw=3.0×105) alginate showed the best film-forming property. Therefore, the appropriate molecular weight should be selected for improving its performance. With freeze-drying technology and pre-freezing at -10°C, we have built the honeycomb materials (porosity=92.06%). Changing the pre-freezing temperature can regulate pore structure to some extent. With the increased dosage of sodium alginate, the porosity and the pore size of the materials were reduced, whereas tensile strength and elongation at break increased. Water absorption performance of the materials was good. The above studies lay a foundation for construction of skin tissue engineering scaffold.


Artificial means for restoring vision of blinds are proved to be able to elicit visual perceptions successfully. Optic nerve stimulation with penetrating microelectrodes is proposed as one of these means to treat the blinds with retina diseases, such as RP or AMD. This study is to investigate the multi-channel microelectrode recordings of multi-unit activities (MUA) in cat visual cortex by electrical stimulation in different patterns and at different sites of optic nerve. The results imply that there is some possible mapping relationship between the optic nerve and visual cortex.


To understand the origin of radio emission in radio-quiet AGN and differentiate between the contributions from star formation, AGN accretion, and jets, we have observed a nearby sample of Seyfert galaxies along with a comparison sample of starburst galaxies using the EVLA in full-polarization mode in the B-array configuration. The radio morphologies of the Seyfert galaxies show lobe/bubble-like features or prominent cores in radio emission whereas the starburst galaxies show radio emission spatially coincident with the star-forming regions seen in optical images. There is tentative evidence that Seyferts tend to show more polarized structures than starburst galaxies at the resolution of our observations. We find that unlike a sample of Seyfert galaxies hosting kilo-parsec scale radio (KSR) emission, starburst galaxies with superwinds do not show radio-excess compared to the radio-FIR correlation. This suggests that shock acceleration is not adequate to explain the excess radio emission seen in Seyferts and hence most likely have a jet-related origin. We also find that the [O III] luminosity of the Seyferts is correlated with the off-nuclear radio emission from the lobes, whereas it is not well correlated with the total emission which also includes the core. This suggests strong jet-medium interaction, which in turn limits the jet/lobe extents in Seyferts. We find that the power contribution of AGN jet, AGN accretion, and star formation is more or less comparable in our sample of Seyfert galaxies. We also find indications of episodic AGN activity in many of our Seyfert galaxies.


T h e atrophy that an innervated muscle undergoes when i t is not used for prolonged periods of time has always intrigued both the basic scientist arid the clinician. T h e basic scientist has used such ingenious means as spinal cord isolation.1.2 tenotomy,2. 3 pinning of joints4 or pharmacological block of nerve impulses5 to achieve this effect. T h e clinician has been faced with the problem of restoring function to muscles atrophied from disuse. Our presentation will touch upon both aspects of this problem.


Scholars have long been curious about the transmission of religious and philosophical ideas across Eurasia in antiquity. It is well known that Mani named a number of important figures from "Eastern" religious traditions—such as Buddha and Zoroaster—among his list of prophetic forerunners in an effort to establish his own authority as a religious teacher. Recently published portions of the Dublin codex of the Manichaean Kephalaia provide an additional attestation of this prophetological paradigm in an even more amplified form, as it includes figures not previously attested. Textual analysis of this new testimonium invites us to reflect on how Mani and his early followers imagined their relationships to other religious traditions. It will be shown that, while Manichaean textual traditions were an important conduit of religious information across Eurasia, modern interpreters should be cautious about supposing that ancient readers of Manichaean texts made any meaningful association between the names of these prophetic forerunners and particular doctrines, which by then had been fully naturalized as "Manichaean" teachings.


In today's embedded software systems development, non-functional requirements (e.g., dependability, maintainability) are becoming more and more important. Simultaneously the increasing pressure to develop software in less time and at lower costs pushes software industry towards product line's solutions. To support product lines for high quality embedded software, quality models are needed. In this paper, we investigate to which extent existing quality modeling approaches facilitate high quality software product lines. First, we define several requirements for an appropriate quality model. Then, we use those requirements to review the existing quality modeling approaches. We conclude from the review that no single quality model fulfills all of our requirements. However, several approaches contain valuable characteristics. Based upon those characteristics, we propose the Prometheus approach. Prometheus is a goal-oriented method that integrates quantitative and qualitative approaches to quality control. The method starts quality modeling early in the software lifecycle and is reusable across product lines.


The lipodystrophy (LD) syndrome is mainly observed as a side effect of the antiretroviral after therapy the introduction of combined therapy including protease inhibitors (PI). The syndrome is characterised by disturbances in glucose and fat metabolism as well as translocation of body fat. The LD-syndrome occurs mainly 6-12 months after beginning of the treatment. However, pathological fat metabolism and hyperglycaemia can be detected after several days or a few weeks. The syndrome can hardly be modified therapeutically. After shifting to a combined therapy without PI some symptoms seem to be reversible. However, this does not apply to all patients.


Alquran is an eternal miracle which is able to become Balagah experts speechless who wants to ignore the guideline of Allah Swt by making great poem which  is  created by themselves. The habitual and Arabian tradition who always vied in versifies the great poem. It caused Al-Qur'an be accepted and be able to developed atop, it is including of words transformation, structural and its style of language. Allah Swt decrees through His messengers with the language clearly and wisely. No one speaks fluently except His prophets. Allah Swt gives them spoken style and teaches them languages and Arabian dialects. Even though, His prophet has not yet communicated in social life with them. Because Allah  Swt wants them become teacher, guide, and Imam  for  all mankind. The style of prophets spoken is balagah (brief, solid, interesting). His style spoken of beautifulness is the second place after al-Qur'an itself. His superiority cannot be defeated by the great poet or the great orator who ever exist. The spoken is clear, beautiful, and calm based the situation and condition, so it is euphony and digestible for All Muslim who want to learn  about Islam fundamental and of course there is no other choices  except learning Arabic. Therefore, Allah Swt always keeps Arabic from extinct.


In the field of the combination between description logics and rule-based reasoning systems, dlprograms have proved to be a very successful mechanism. One of their recognized shortcomings, however, is their lack of full tightness: the language constructs that feed data from the logic program have a local effect, leaving the knowledge base essentially unchanged throughout. In this paper, we present a construction that we call lifting, which allows predicates to be fully shared between the two components of a dl-program in a systematic way, and show how lifting can be used to provide intuitive solutions to a number of everyday reasoning problems involving the verification of integrity constraints and the implementation of default rules. This construction preserves consistency of the underlying knowledge base and complexity of the overall system. Furthermore, the resulting semantics of default rules has a natural interpretation under the original Reiter semantics.


The present invention relates to a charger for a mobile communication terminal, and more specifically, whether the manufacturer and model, relates a mobile communication terminal charger capable of charging all mobile communication terminals or battery is there. To achieve the above object, the present invention includes a housing (20), the battery mounting portion (21), a battery fixing unit (22), a battery sensor portion (73), horizontal and vertical charging terminal unit (25 provides a 26), limit switch section (37, 47), the control unit (28), the mobile communication terminal charger including a charging circuit unit (27).


Although the principal antigenic determinant in pencillin allergy is known to be the penicilloyl group which results from aminolysis of the penicillin with +amino group of protein (see reviews by Schwartz, 1969; Schneider, 1970), the simple reaction between penicillin and primary amines under physiological conditions proceeds slowly. It thus appears that catalysis is likely to play a considerable part in the biochemical antigenicity reactions of penicillins. It has recently been suggested that compounds containing both nucleophilic and general acid-base groups are capable of exhibiting high reactivity in the formation of a penicilloyl conjugate at neutral pH (Schneider & de Weck, 1968; Schwartz, 1969; Schneider, 1970). In 1968, Schneider & de Weck and Schwartz reported such an instance in the reaction with aliphatic diamine derivatives. Most recently, we have reported (Yamana, Tsuji & others, 1975b) another possibility for intramolecularly catalysed penicilloylation in the reaction between aminoimidazole compounds and several penicillins. We now report an example of penicilloylation in which a hydroxyl group assisted intramolecularly by general-base catalysis of the amino group in aminoalcohols reacts with benzylpenicillin (BPC). Schneider & de Weck (1968) have demonstrated that the reactions of BPC with N-carbobenzoxyand N-acetyl-serines proceed at appreciable rates even under the physiological conditions through the formation of 0-penicilloyl serine derivatives. However, it is doubtful whether the observed reactions would be the result of intramolecular catalysis because an oxygen attack assisted by the N-acylated moiety is unlikely. In aqueous buffers of aminoalcohol derivatives (see Table l), the first-order rate constants, kobs, for the degradation of BPC were determined at 35" and 60" ( p = 0.5)


The Novel Corona virus, popularly known as COVID-19, has crossed all borders in a very short period of time and has spared no continent except Antarctica. Some advanced countries are affected more severely than others; with United States of America, Spain, Italy, China, Germany, France and UK being the worst affected of all with a few more are joining them soon. Several countries has locked-down to prevent further spread of the virus. This resulted in severe economic and health impacts on the public at large.


Objective To compare the effect of different tidal volumes(TV)and mechanical ventilation(MV)with positive end-expiratory pressure(PEEP)on patients with post-resuscitation syndrome(PRS),and discuss the ventilation strategy in cardiopulmonary resuscitation(CPR).Methods Thirty-six patients with PRS after cardiac arrest admitted in our hospital between December 2008 and December 2011 were randomly and evenly divided into group A1,group A2,group A3,group B1,group B2 and group B3.Low TV(6 ml/kg)plus low PEEP(3 cm H2O)was applied to patients of group A1,low TV(6 ml/kg)plus medium PEEP(6 cm H2O)to group A2,low TV(6 ml/kg)plus high PEEP(12 cm H2O)to group A3,routine TV(10 ml/kg)plus low PEEP(3 cm H2O) to group B1,routine TV(10 ml/kg)plus medium PEEP(6 cm H2O)to group B2,and routine TV(10 ml/kg)plus high PEEP(12 cm H2O)to group B3.Timing was started after restoration of spontaneous circulation(ROSC).Patients′oxygenation index(OI),blood gas analysis(pH,PO2,PCO2),central venous pressure(CVP),dopamine dose for basal MAP maintenance,heart rate(HR),hepatic and renal function(ALT,TBiL,Cr),and Glasgow coma score(GCS)were measured and recorded at 1 h,6 h,12 h and 24 h.Results PO2 and OI at 24 h was significantly lower than that of 1 h,6 h and 12 h in all groups(P0.05).PO2 and OI at all time points in group A1 was significantly lower than that of group A2 and A3,and that of group B1 was lower than that of group B2 and B3(P0.05).Dopamine dose for basal MAP maintenance,HR and CVP reached the highest at 6 h and decreased gradually during 12~24 h in all groups.Dopamine dose for basal MAP maintenance,HR and CVP at 6 h in all groups was significantly different from that of 1 h and 24 h(P0.05).ALT,TBiL,Cr at 12 h and 24 h was higher than that of 1 h in all groups(P0.05).The pH increased to normal level at 6 h and decreased gradually after 6 h in all groups,and at 1 h and 24 h in group A2 was significantly different than that of 6 h(P0.05).The pH at 12 h and 24 h in group A2 was significantly higher than that of other groups(P0.05),ALT,TBiL,and Cr at 12 h and 24 h in group A2 was significantly lower than that of other groups(P0.05).GCS was low within 24 h in all groups.GCS at 12 h and 24 h was significantly higher than that of 1 h in group A2(P0.05).GCS at 12 h and 24 h in group A2 was significantly higher than that of other groups(P0.05).Conclusion Low TV(6 ml/kg)plus medium PEEP(6 cm H2O) may be more reasonable ventilation strategy to be applied to patients within 24 hours after CPR.


Background : To evaluate the electroretinographic relsuts and to assess the role of electroretonogram(ERG) in cases of central retinal vein occlusion (CRVO). Methods : ERGs were recorded on 21 patients who were diagnosed as CRVO with the mothod recommended by international society for clinical electrophysiology of vision (ISCEV) using Leight Krossowsky Chen (LKC) UTAS E-3000. The patients were classified as ischemic and non ischemic CRVOs by the findings ‐ of fluorescein angiogaphy (FAG) and ocular physical examination. ERG results of the involved eyes were analyzed and compared with the findings of contralateral eyes. Results : The b wave implicit time and amplitude of scotopic 0.01, a and b wave implicit time, b wave


We first determine a necessary and sufficient condition for a functionfe C*(X), which extends to a compactification of X, to extend to a smaller compactification. We apply this result to show that when l3X\Xj _ Ko there is anfe C*(X) which extends to no compactification other than fAX. Two examples show that when N0 oC2X if there is a mapping h:0oCX-*oC2X such that hlX=id. If oC1X>aC2X and they are not equivalent we write oClX> oC2X. Our first result is a necessary and sufficient condition that a given element of K(f) will be minimal with respect to this order. THEOREM 1. ocX is a minimal element of K(f) if and only iff' is 1-1 on ocX\X. Presented to the Society, November 25, 1972; received by the editors May 11, 1972. AMS (MOS) subject classifications (1970). Primary 54D35.


Excess molar volumes of the 1,4-dioxane + ethane-1,2-diol liquid mixture were measured at 298K using a dilution dilatometer. The observed composition dependence does not confirm the W-shaped form as suggested by some other data published in the literature.


Collins Booksellers was taken over by the Collins franchisees, after the collapse of Collins Booksellers. The franchisees had grouped together and bought what reminded of Collins Booksellers intellectual property, IT and what was left of the merchandising and brand stock.


This review paper consolidates information with special reference to the systems of concentrate feeding to dairy cows with grass silage adlibitum. The additional knowledge on genetic potential of cows and the milk yield, feeding and lameness in animals is also included in the review. Feeding of concentrates as per milk yield of a cow or feeding of fixed amount (Flat rate) of concentrates to each cow had little or no effect on the milk yield and the milk composition. The fixed quantity of concentrates fed at high/low stepped rates or the nate the rate of concentrate feeding did not alter the milk yield and the milk composition significantly. Complete diets generally increased the Intake of feed and the milk fat contents as compared to separate feeding of concentrates and forages. High genetic potential cows have higher feed intakes and produced more milk than medium and low genetic potential animals. The higher ratio of concentrate to forage increases incidence of lameness in dairy animals.


Grounding electrode resistance non-linearly changes under impulse conditions due to soil ionisation phenomenon. Several models have been proposed to model soil ionisation for grounding electrodes applications. However, to date, there is yet an attempt made to compile all these works into a comprehensive review article. Therefore, this paper is written with the objective of summarizing all related works in this field as a one- stop reference. With reference to the literature, this paper is written to summarize the working principles of the soil ionisation models as well as the accuracy and performance analysis of the models. This paper, particularly highlights the deficiencies of the available models in terms of accuracy and performance. This knowledge will contribute to the development of a new accurate and efficient soil ionisation model.


Recently, an efficient single‐layer organic light‐emitting diode has been reported, consisting of a neat layer of the diboron‐based thermally activated delayed fluorescence emitter 5,10‐bis(4‐(9H‐carbazol‐9‐yl)‐2,6‐dimethylphenyl)‐5,10‐dihydroboranthrene, exhibiting remarkably balanced bipolar electron and hole transport. Here, the donor–acceptor–donor architecture of the molecule is linked to the transport characteristics of its neat amorphous films. It is found that energetic disorder is larger for holes than for electrons, explaining the experimentally observed difference in temperature activation of the mobility. Although a difference in energetic disorder would suggest unbalanced charge transport, it is demonstrated that it is partly counteracted by larger coupling elements for holes.


Standard treatment for newly diagnosed glioblastoma (GBM) is surgical resection followed by radiation with concurrent temozolomide (TMZ). For those who do not respond there are few clinical options, survival is low, and there no biomarkers to direct the decision of second-line treatment. We have developed a 3D cell culture assay to predict response to TMZ and 11 other potential therapies for GBM. Our assay uses GBM tissue obtained at surgical resection and the test's 7-day turnaround maximizes clinical actionability of results. We performed a small, prospective study examining the ability of the assay to predict response to TMZ. Ten newly diagnosed GBM patients were enrolled over 12 months. Two patients were removed due to refusal of treatment, and three failed the assay (3/8, 62.5% success). The remaining five patients received radiation and concurrent TMZ following surgical resection. Using progression-free survival (PFS) measured from the completion of radiation therapy and setting 4 months as the cutoff for response, we were able to determine the ability of our assay to predict TMZ response. The assay correctly predicted all five patients (100%). The average PFS for the two predicted responders was 8 months compared to the three predicted non-responders at 3 months, p = 0.0634. In this limited dataset, MGMT methylation did not appear to play a role as two of three predicted non-responders were methylated along with one of two predicted responders. Average overall survival of the predicted TMZ responders was 13 months compared to 6 months for the predicted non-responders, p = 0.0634. This early data indicates the potential for this assay to inform clinicians of the best course of action for their patients. Further enrollment of patients into the 3D-PREDICT clinical trial will provide a larger dataset for better validation of the predictive value of this new assay.


Objectives: Test performance is conventionally expressed by gain in diagnostic certainty. We propose net diagnostic gain and indication area as more appropriate measures of test performance; then, the loss in certainty due to misclassification and the information of ''no test'' would be performed are taken into account. Study Design and Setting: A decision analytical model was developed in which two alternative strategies were compared: testing and no testing. Correct diagnostic test results received a positive value; undesired test results received a negative value. Within the ''no test'' scenario, it was assumed that physicians are more prone to treat as the probability of disease is higher. Results: Discounting gain and loss in diagnostic certainty results in a concave function of the prior. The indication area is the range of priors with a net diagnostic gain; testing is deleterious beyond this range. The net diagnostic gain reaches a maximum at a specific prior. A freely available Web site-based calculator was developed for easy calculation of the indication area and the maximum diagnostic gain for each combination of sensitivity and specificity. Conclusion: Medical testing is not indicated when the prior disease probabilities are low (as to screening for a condition) or high (for diagnostic confirmation). Published by Elsevier Inc.


The invention provides an automobile skylight rail cleaning device which comprises a supporting rod. A trapezoidal box is arranged below the supporting rod, the trapezoidal box on the left side is provided with a dust outlet, a rotating bearing is penetratingly arranged in the middle of the right side of the trapezoidal box, an annular cleaning ring is annularly fixed outside the rotating bearing, and axis of the rotating bearing is connected with a manual rocker arm. By the automobile skylight rail cleaning device, dirt like sundries and flying dust in an automobile skylight can be removed effectively, and damage to the automobile skylight due to bar-shaped articles can be reduced effectively; through effective cleaning, cleanliness of the skylight can be maintained, so that service life of the automobile skylight is further prolonged, and economic loss caused by the fact that the automobile skylight is damaged and needs to be replaced is avoided.


Abstract : The Department of Defense (DOD) and its service branches have placed increasing attention on defense expenditures. The importance of finding new cost reduction methods cannot be over-emphasized. DOD packaging costs are significant. These costs can probably be reduced by the application of proven management techniques. This research effort applies accepted life cycle cost techniques to the area of packaging decisions. The application of these techniques can act as a decision tool for selecting preferred alternatives. Air Force Logistics Command (AFLC) packaging managers have indicated that a life cycle cost model would be of invaluable assistance to their Air Logistics Center (ALC) item managers (IM) as well as Air Force Systems Command's System Program Offices (SPO), in the selection of package types.


This paper reviews the challenges posed by the physics of the interaction of high-peak power femtosecond lasers with ultrathin foil targets. Initially designed to produce warm solid-density plasmas through the isochoric heating of solid matter, the interaction of an ultrashort pulse with ultrathin foils is becoming more and more complex as the laser intensity is increased. The dream of achieving very hot solid density matter with extreme specific energy density faces several bottlenecks discussed here as related to the laser technology, to the complexity of the physical processes, and to the limits of our current time-resolved instrumentations.


@Stephwrks: Another separate but simple option could be to run two WP sites, one primary one running Pique theme and a secondary one living inside


The Journal of Ecology and Environmental Sciences (IJEES),ISSN: 0976–9900 & E-ISSN: 0976–9919, aims to publish all the latest and outstanding research articles, reviews and letters in all areas of pure and applied ecology (i.e., plant, animal, microbial and human ecology) and environmental science including environmental pollution, conservation, resource management, sustainable development and global change. Each issue contains a series of timely, in-depth written articles by leaders in the field, covering a wide range of the integration of multidimensional challenges of research including integration issues of the Ecology and Environmental Sciences research.


In the face of President Trump's proposed annual budget cuts of $47.9 billion for federal graduate medical education programs over the next decade, the medical profession is urging Congress to approve legislation to significantly increase federal GME support and help combat looming shortages in both primary and specialty care.


This paper introduces the connotation of college students' employment ability,lists the employment difiiculties and growing demand performance of poor students in medical colleges,and analyzes the causes of weak motivation for growth of the poor students,on this basis,to explore the systematic construction path and inner harmony and promote employment ability of poor college students.

Key words:
Medical college;  Poor students ;  Employment;  Growth aspirations;  Way ; Harmonious development


This proposal is concerned with applications of Monte Carlo to problems in physics and chemistry where rare events degrade the performance of standard Monte Carlo. One class of problems is concerned with computation of various aspects of the equilibrium behavior of some Markov process via time averages. The problem to be overcome is that rare events interfere with the efficient sampling of all relevant parts of phase space. A second class concerns sampling transitions between two or more stable attractors. Here, rare events do not interfere with the sampling of all relevant parts of phase space, but make Monte Carlo inefficient because of the very large number of samples required to obtain variance comparable to the quantity estimated. The project uses large deviation methods for the mathematical analyses of various Monte Carlo techniques, and in particular for algorithmic analysis and design. This is done in the context of relevant application areas, mainly from chemistry and biology.


The manifestations of control in the verbal grammar of Yucatec Maya are investigated. In the semantic structure of a situation, a distinction between participant features, situation features and role features is made. In general, role features are grammaticalized to a much higher degree in Yucatec Maya than participant or situation features, and also to a higher degree than in other languages. There is a highly regular association of control properties with intransitive conjugation classes. Transitive verbs are more confined to the typical "transitive" situation, i.e. one with a clear control incline, than in many other languages. There are derivational operations which convert control into non-control verbs and vice versa and which are sensitive to control properties of their base.


Possessing the unique feathers of high targeting and inducing the active immunity of patients,magnetic-mediated hyperthermia(MMH)has been regarded as a very promising cancer-treatment approach.Researches about in-stent MMH for esophagus cancel have been widely carried out with focusing on heating mechanism,feasibility studies and clinical trials.

Key words:
Esophageal neoplasm; Hyperthermia,induced; Stents


Finding maximum instantaneous power consumption helps estimation of worst-case supply voltage drop and lifetime of a VLSI system. We observe signal correlations represented by logic inversions, and present a maximum subgraph two-coloring formulation for the problem. We show the problem is NP-hard, and the complexity comes from the presence of reconvergent fanouts besides inputs signal correlations. We further develop an efficient algorithm for general VLSI designs of practical sizes. Our experimental results on the ISCAS'89 benchmark show our subgraph coloring algorithm achieves 4.31% less standard deviation of maximum instantaneous power estimate than the greedy transition assignment algorithm in [12]; and a 2.82% standard deviation of maximum instantaneous power estimate with 2-3 orders of runtime speedups compared with pattern-dependent simulation techniques.


Each volume percent concentration of the components in gasoline was determined by gas chromatography,and the evaporation pressure of gasoline was calculated based on the volume percent concentration of each component and its partial vapor pressure at the temperature of 37.8 ℃.This operation method adopted during the process control of catalytic gasoline production was simple to use,and when the determination result was compared with the standard,its deviation was less than 0.96%.


Ninety naturalized and four commercially introduced subterranean clover strains present in Western Australia were examined. Flowering time, hardseededness, contents of the oestrogenic isoflavones formononetin, genistein, and biochanin A, and plant morphological characteristics were measured in spaced plants. Probabilities of random relationships were calculated for all character pairs. Wide variation was found among strains for all characters measured. A number of strains had low oestrogenic isoflavone contents. Levels of the three isoflavones appeared to vary independently of each other and of all other characters. Hardseededness decreased with lateness of maturity, but evidence is adduced that the relationship was not causal. Correlations were recorded among several morphological characters. Some 20 naturalized, non-commercial strains were selected as worthy of further agronomic study.


3047 Background: The aim of this study was to evaluate the activity and toxicity of a multistep, sequential treatment including induction chemotherapy (ICT), consolidation chemoradiotherapy (CXRT), and maintenance immunotherapy (MI) in untreated patients with locally advanced (LA), inoperable, or incompletely resected Pa and Bt ADK. MI with low-dose interleukin-2 (IL-2) and 13-cis-retinoic acid (RA) was given in order to enhance the immune function, which could eradicate minimal residual disease, as previously shown (Clin Cancer Res 2001).

METHODS
From September 2003 to September 2007, 54 patients, 32 men, 22 women, 63% with Pa and 37% with Bt ADK, mean age of 63 years (range 36-75), were treated with an ICT consisting of 3 courses of cisplatin, 70 mg/m2 day 1, gemcitabine 1000 mg/m2 day 1 and 8 every 3 weeks. Patients who were progression-free (PF) after ICT received CXRT, 45 Gy in 25 fractions, using coplanar four-field technique, with concurrent capecitabine 850 mg/m2/day. Six weeks after completion of CXRT, patients were restaged: In the absence of disease progression, they received, as an MI, IL-2, 1.8 x 106 I.U. and RA, 5 mg/kg, 5 days/week, 3 weeks/month for 1 year and thereafter until progression.

RESULTS
After a median follow-up of 27.5 months, all patients were evaluable. A response rate of 26% (95% c.i. 15-40%), was observed, with 44.5% of patients achieving stable disease. Thirty-eight patients, 27 with Pa and 11 with Bt ADK, had a clinical benefit from ICT, and were treated with CXRT. Fourteen PF patients, 7 Pa and 7 Bt ADK, received an MI with IL-2 and RA. Median progression-free survival (PFS) and overall survival (OS) for all 54 patients were 6.8 and 12.1 months, respectively, while the 14 patients treated with MI had a 5-year PFS and OS rate of 36% and 58%, respectively. Grade 3-4 hematological and gastrointestinal toxicity were observed in 30% and 37% of patients, respectively, while 28% of patients had grade 1-2 autoimmune reactions.

CONCLUSIONS
These results support the efficacy and safety of a multistep sequential treatment with ICT, followed by CXRT, and an MI with IL-2 and RA, in patients with LA, inoperable or incompletely resected Pa and Bt ADK. Further studies are necessary to validate this strategy. No significant financial relationships to disclose.


Based on the explanation of the importance of definite total volatile organic compound (TVOC), the definition of total volatile organic compound (TVOC) is discussed, TVOC should be the total of measured known and unknown volatility organic compound the air in the positive hexadecane retention time before. In addition, according to the practice, total volatile organic compounds (TVOC) in heating conditions appropriate procedures according to different equipment optimizing themselves.


An attempt has been made to consider the problem of the place of dispositive transactions in the system of juridical facts. It is concluded that a dispositive transaction is a legal act.


OBJECTIVE
To investigate significance of the distribution and thickness of cancellous and cortical bone in the mandibular ramus using computed tomography (CT) in the design of osteotomy at the medial aspect of the ramus.

METHODS
45 cases with class III prognathism underwent CT before operation. The distribution and thickness of cancellous and cortical bone in the mandibular ramus was measured every 2.5 mm thick from mandibular lingular plane to 20 mm above it.

RESULTS
The upper ramus was separated by cancellous bone in only 37.5% of the cases. The other cases had no cancellous bone in the upper ramus. 5 mm above the lingual, the thickness of cortical bone at the lingual aspect decreased from the front to the behind with an average thickness of 1.55 mm. The distance from lingual to the fusion at the posterior border of ramus was 9.45 mm.

CONCLUSIONS
The medial cortical osteotomy should be located within 5 mm above the lingual and within 9.45 mm posterior to the lingular. The osteotomy could be slightly oblique and become deeper from behind to the front with an average depth of about 2 mm.


This article analyses the convergences and divergences between two academic 'analytic traditions' on the subject of alterity: Anthropology and Postcolonialism. Setting out from the example of the caste debate in India, it seeks to illustrate the scopes and limits of the anthropological and postcolonial approaches. Since both offer the potential for valuable analyses, the author suggests treating them as complementary and proposes the elaboration of a plural analytical perspective.


Liquefactive necrosis of the lung tissue caused by microbial infection, lung abscess is characterised by formation of cavities containing necrotic debris. In the vast majority of cases of lung abscess, polymicrobial bacteria can be found with predominance of anaerobes. Mycobacterium has been described as a very rare causative agent of community acquired lung abscess. We are presenting a case of middle aged diabetic female, who had bilateral lung abscesses, aetiology of which was established to be tubercular. Astonishing it may sound; based upon extensive web and library search, it's the first case report on tubercular lung abscess in a diabetic from India, and perhaps from the world itself.


This is a qualitative research in the Juiz de Fora Specialized Care Service, in the State of Minas Gerais. The objective was to understand the feelings of women when they find out they are HIV-positive during pregnancy. We found that this made women feel despair, the fear of death, physical disfigurement, discrimination, prejudice, as well as concern for their children. In order to face up to the disease in their daily life they quoted: religious faith, support from the family


One kind of cross-track plunging constant velocity joint assembly comprising an inner ring having an outer diameter, axial length, the inner ball raceway and a transmission spline member is engaged with the first torque. An outer ring having an inner diameter, an outer diameter and an outer ball tracks. The outer ring is connected to the second torque transmission member. Holder arrangement having a plurality of windows in between the inner and outer rings. A plurality of balls (N) having a ball diameter is held by the frame held in the window, the inner and outer ball and joined to the raceway. Balls define a joint pitch circle diameter (PCD). Inner outer circle having the mobile depth. Satisfy the ratio 1.2 ≦ (outer ring outer diameter / outer ring inner diametric) ≤1.7 a.


(21) Appl. No.: 14/713,280 (57) ABSTRACT (22) Filed: May 15, 2015 A method of making a contact lens comprising the steps of Related U.S. Application Data reacting in a mould a polymerisable formulation comprising (63) Continuation of application No. 13/497,097, filed on at least one fluorine-containing silicone monomer at least one Mar. 20, 2012, now Pat. No. 9,057,821, filed as applinon-fluorine-containing silicone monomer and at least one cation No. PCT/EP2010/065248 on Oct. 12, 2010. hydrophilic monomer to form a contact lens, Subjecting the contact lens to one or more solvent extraction steps to remove (30) Foreign Application Priority Data impurities, oligomers and unreacted monomers and hydrate


IN THE July, 1901, number of the Buf fa lo Medica l Jou rna l , the writer illustrated two cases of splenomegaly in the course of malaria; the one, a recent estivoautumnal malaria; the other, a splenic anemia, probably of malarial origin. The case, which is reported in this issue, is of interest, illustrated a tremendous splenic enlargement and hyperplasia of lymphatic nodes from a different origin:


Daniels A wide variety of easily programmed amplitude and frequency sweep combina tions features. a user-defined vector math capability are some of the features. A Broadband Two-Port S-Parameter Test Set, by William M. Spaulding Clever trans former decades stripline designs allow operation over a frequency range of three decades 17 and one octave. 21 An ADC for a Network Analyzer Receiver, by Alan J. Baker This two-pass-conversion design allows a 12-bit ADC to cover a 17-bit dynamic range.Claude without and Jacques Firdmann Take this unit right out to the shop floor without worry, because water spray or dust won't affect it. O O Energizing two columns of printwires in a moving printhead at the right times with the right force printers. a complex task. This single 1C does it for a family of printers. A network analyzer for the R&D lab, a rugged, sealed terminal for the shop floor, a family of printers for the automated office. These products may not seem to have much in common, and they don't, except that they're all made by Hewlett-Packard and you can read about them in this issue. The HP 3577A Network Analyzer measures the transmission and reflection characteristics of electronic components and networks over a frequency range built-in 5 hertz to 200 megahertz and displays the results on its built-in CRT, as shown in the cover photo. This high-performance instrument is being used by designers and manufacturers to test telecommunications A story is a story of skillful, state-of-the-art design. Its bandwidth, dynamic range, accuracy, resolution, and sensitivity are as good as you'll and in this kind of product. It makes complex measurements easy to set up and perform. It manipulates results to its user's liking without a computer, but it can also operate under computer control. There's no magic behind any of this, just good design. Precise analog design for broad bandwidth. Digital signal processing for accuracy and display flexibility. Microprocessor control for simplicity of operation. For the details, read the articles on pages 4, 17, and 21. The HP 3081 A Industrial Workstation Terminal, described by its designers in the article on page 25, has a compact, personal miniterminal designed for low-cost factory data collection. It has big keys grease, are easy to operate with gloves on, and it's protected against dust, dirt, grease, oil, and liquids. You can clean it with any liquid soap or detergent and rinse it …


This paper discusses the characteristics and determinants of entrepreneurial behaviour in Uganda. It is based on a recent survey of urban and rural entrepreneurs, executed in May 2008. The main dependent variables are business success, gestation activities and innovative performance. The paper focuses in particular on the interplay of human and social capital in determining entrepreneurial performance. A prominent question in the literature is whether human capital and social capital act as complements or substitutes in furthering entrepreneurial dynamism.


This study aims to identify diction which is related to message logic in communicating on social media. The identification is carried out based on Deddy Corbuzier's podcast that is aired on YouTube. The analysis of diction is an interesting study when, as one of the reasons, it is related to the efforts to effectively convey messages that are beneficial to a society. This study combines the concept of diction and Message Logic Theory, particularly "message design logic." The method applied is observation on the data source in the form of a video recording with note-taking techniques by which identification, classification and data reduction could be carried out. There are two main results in this study. First, the diction includes general words consisting of graded words and abstract words, and particular words consisting of proper names and the words that have suggestive power. Second, the dominant message logic that appears in Deddy Corbuzier's podcast episode "Malih, Pesan Pedas Tuk Ade Londok" (Malih, Sharp Message for Ade Londok) is expressive logic and rhetorical logic. The implication of this research on diction and communication logic is a description of the importance of choosing the right words in public spaces. This study also recommends other researchers to do further researches by using more speech data so that public communication patterns can be mapped better.


To estimate the association between elective induction of labor and cesarean section in low‐risk parous women, and to assess whether the association is influenced by induction method.


OBJECTIVE A HPLC method was established for the determination of the ciprofloxacin in raw milk.METHODS The separation was performed in a VP-ODS(250mm×4.6mm,5μm) column with 0.05mol·L-1 Citric Acid-acetonitrile-triethylamine(80∶20∶0.3) as mobile phase.The flow rate was 1mL·min-1 and the detection wavelength was 277nm.RESULTS The linear range of the method was 0.005~1.0μg·mL-1 for the ciprofloxacin,the related coefficient was 0.9991,the detection limit was 0.003-0.005μg·mL-1,the average recovery rate was 99.4%,and the RSD was 0.56%.


Idioms are the basic components in English vocabulary, which comes from real life, religion, anecdotes, fables, legends and historical stories.


So you think the NHS has changed in the last 10 years? Read 'The Future Healthcare Workforce', the report of the project steering group chaired by Professor Michael Schofield of Manchester University, and you will realise that you have probably only seen the tip of the iceberg.


Growth model is confined when the yield per recruitment(YPR) is calculated using the classical Beverton-Holt model.A numerical method is employed to compute the YPR when any growth model is adopted.The results show that the method in this study can obtain numerical value of YPR with a high accuracy when use of any growth model.The errors of numerical results are mainly caused by the parameters in the relationship between length and weight.There are some differences between the valves of YPR calculated with the different growth models for a particular species.It's more suitable to adopt the most appropriate growth model when calculating YPR with Beverton-Holt model so as to obtain more reliable assessment results.As example,YPR was analyzed for Pseudosciaena polyactis in Liaodong Gulf and Sebastes aleutianus in southeastern Alaska.


The phase 3 KATHERINE trial demonstrated significantly improved invasive disease–free survival with adjuvant trastuzumab emtansine (T‐DM1) versus trastuzumab in patients with HER2‐positive early breast cancer and residual invasive disease after neoadjuvant chemotherapy plus HER2‐targeted therapy.


Obscurants containing glycols and glycerin, which are widely used in the entertainment industry to produce theatrical effects, are now being used in more concentrated forms in antitheft and riot control. While there have been several studies demonstrating that theatrical fogs are innocuous for humans, the toxicity of the denser fogs has not been examined. In this paper we review the results of previous safety studies of theatrical fog, summarize the effect of increasing concentrations of these obscurants on visibility, and then report on the physiological and biochemical impact of higher concentrations of these obscurants for several hours in rats. Our results suggest that even prolonged exposure to highly obscurant levels of propylene glycol / glycerin fog produces only minimal physiological aftereffects.


Abstract W, W–15 at-%Al, W–30 at-%Al and W–45 at-%Al coatings were synthesised by using a reactive four-target DC closed field unbalanced magnetron-sputtering ion plating system. Structure, morphology, composition, hardness and adhesion were studied by using an X-ray diffractometer, an energy dispersive spectrometer, a scanning electron microscope, a scanning transmission electron microscope and nanohardness and scratching testers. Wear performance was evaluated by using a pin-on-disk wear tester. The sputtering deposition of this binary system led to the formation of single-layer W–Al coatings as a result of complete dissolution of the Al atoms into the W lattice during the depositing process. The W–15 at-%Al coating showed improved wear resistance as compared with the W coating.


The growth sequence of Al, Ge, and Ni metals was shown to dramatically affect the amount of heat treatment time required to convert the electrical properties from Schottky to ohmic behavior. Differences in the heat treatment times required to convert from rectifying to ohmic contact were dependent on the doping concentration of the contact layer and on the heat treatment temperature. Interdiffusion of component elements and phase formation have been studied to determine the origin of these effects. Auger depth profiles and X-ray diffraction have been used to determine the interdiffusion and phase formation resulting from various types of thermal processing. Elemental profiles and identification of phases of Ni-Ga, Ni-As, and Ni-Ga-Ge will be used to explain the origin of ohmic behavior.


© BMJ Publishing Group Limited 2021. No commercial reuse. See rights and permissions. Published by BMJ. DESCRIPTION A 40yearold man presented with painless swelling of the neck for 3 years. He was well until 3 months prior to the presentation when he started losing weight and feeling lethargic. Clinical examination showed an enlarged left cervical lymph node measuring about 4×4 cm. Lymph node biopsy revealed scattered mononuclear Hodgkinlike cells and binucleated ReedSternberg cells with CD30 positivity in keeping with classical Hodgkin lymphoma. Staging Positron emission tomography (PET)CT scan showed multiple hypermetabolic supradiaphragmatic nodes. Bone marrow aspiration and trephine biopsy were unremarkable. He was then commenced on ABVD chemotherapy (doxorubicin, bleomycin, vinblastine and dacarbazine). Reassessment after three cycles of chemotherapy showed significant clinical and radiological improvement. However, he reported hyperpigmentation of all the nails which had developed 2 months after the commencement of chemotherapy (figure 1). There was no mucosal pigmentation or skin lesion elsewhere. He denied taking any medication or supplement. He was diagnosed with chemotherapyinduced transverse melanonychia. Melanonychia is a result of increased melanin deposition in the growing nail beds. Transverse, longitudinal and diffuse form of melanonychia have been described. The mechanism of melanonychia can be due to melanocytic activation or melanocytic hyperplasia. Melanonychia affecting multiple nails can be physiological, occurring as a normal variant in skin of colour and during pregnancy. It can be seen in association with certain syndromes and can also occur secondary to local trauma, chronic nail infection, inflammatory skin disease, endocrine disorders, nutritional deficiency, systemic disease, medications, phototherapy and Xray exposure. Transverse melanonychia is uncommon and frequently observed in association with medications. Chemotherapeutic agents including doxorubicin, bleomycin and dacarbazine have all been recognised to cause transverse melanonychia. The intermittent cycles of chemotherapy exert direct toxic effects on nail matrix causing melanocytic activation, which leads to the development of transverse melanonychia. It typically resolves after the completion of chemotherapy and warrants no treatment. Interestingly, the occurrence of this clinical sign is not frequently seen in patients receiving chemotherapeutic agents. The sparing of the lunula in transverse melanonychia is also rarely described. Hence, the recognition of this benign nail condition is essential to avoid unnecessary investigation or treatment.


Promoted by cloud technology and new websites, plenty and variety of Web services are emerging in the Internet. Meanwhile some Web services become outdated even obsolete due to new versions, and a normal phenomenon is that some services work well only with other services of older versions. These laggard or improper services are lowering the performance of the composite service they involved in. In addition, using current technology to identify proper semantic services for a composite service is time-consuming and inaccurate. Thus, we proposed a clustering method and a recommendation method to deal with these problems. Clustering technology is used to classify semantic services according to their topics, functionality and other aspects from plenty of services. Recommendation technology is used to predict the possible preference of a composite service, and recommend possible component services to the composite service according to the history information of invocations and similar composite services. The experiments show that our clustering method with the help of Ontology and TF/IDF technology is more accurate than others, and our recommendation method has less average error than others in the series of missing rate.


GaAs Schottky barrier diode (SBD) based terahertz mixer and frequency multiplier represent one of the most important method for terahertz signal emitting and receiving from 0.5THz to 5THz. Compared with original GaAs substrate, quartz using as GaAs SBD circuit base could suppress transmission loss and high order transmission mode on chip, benefits from low dielectric constant of quartz. In this paper, GaAs SBD was integrated on quartz substrate using transfer printing technique, which could achieve membrane device transfer and low cost high output of original GaAs wafer.


The results of the research of a hydraulic stream, dispersion of which is carried out by the generation of pulsations of pressure in a stream outflowing from the sprinkler (hydroimpulsive liquid jet) are presented. On the basis of phenomenological analysis of the data of high-speed photography of the liquid jet, we pick out the elementary constituents of process of dispersion including: - forming the sequence of identical portions of liquid, consisting of high-speed and low-speed liquid jets; - their non-elastic collision, attended with transformation of the portion in a structure consisting of a drop and remaining area of low-speed stream, which are crushed in the gas stream flowing them around, forming a total torch. The mathematical model of dispersion taking into account the features of physical picture of process has been developed, the formulae linking dispersion characteristics, form of torch and jet range with frequency and amplitude of the pressure pulsations generated in a stream have been got. The conducted experiments have shown the good coincidence of their results with design data. The results obtained can find wide application for creation of thermal screens, suppression and disinfection of the harmful blowouts, fire extinguishing and so on.