We thank Dr. Alvarez and colleagues for their valuable comments on our article. The authors have brought to our attention the potential existence of local variations in practice across the two medical centers on the basis of different proportions of patients receiving anesthesia. A difference in the percentages of patients receiving anesthesia, however, does not necessarily indicate differences in local practices. Such differences can also be attributed to variations in several patient and disease characteristics within the two cohorts. In addition, both centers conducted the study and data collection in a very similar manner, with predefined data points assessed retrospectively. However, we acknowledge the possibility of remaining information bias. This is why we clearly stated that our results do not claim any causality. The colleagues further often refer to "early intubation," but our results showed the benefit of early anesthesia, not intubation. In fact, patients in whom anesthesia was induced for reasons other than persistence of status epilepticus (SE; i.e., primarily for intubation to protect the airways, etc.) were excluded, as stated in our Limitations and strengths section. Furthermore, patients may undergo intubation without the concurrent and continuous administration of anesthetics, particularly in cases where they remain in a comatose state either due to ongoing SE or during the postictal period. In addition, in our clinical experience, when appropriate doses of benzodiazepines are administered as firstline treatment for SE, the airways tend to remain secure in most patients. In addition, benzodiazepines are more commonly underdosed than overdosed in clinical practice.1 The authors rightly refer to the lack of comparison between patients treated with and without anesthetics as a potential source of a selection bias. In our previous study, where we examined the safety and efficacy of anesthesia following firstline treatment in SE, we compared patients who received anesthesia after firstline treatment to patients who underwent treatment escalation according to guidelines, thereby including patients who did not receive anesthesia.2 That previous investigation revealed a shorter median SE duration and intensive care unit and hospital stay in patients who received anesthesia following firstline treatment, without an increasing number of complications. However, we acknowledge that in certain patients the seizures may have ceased after repeated administration of recommended firstline treatment if the clinician had resisted their initial judgment and had not proceeded with treatment escalation toward anesthesia and had opted to wait instead. It is unfortunate that studies investigating the administration of anesthetics in SE, particularly in prehospital settings, are inherently limited by their retrospective nature, the involvement of nonneurologists during the initiation of first treatment steps, and the lack of readily available electroencephalography (EEG) monitoring. Overall, we agree that our findings do not suggest that inducing anesthesia earlier than currently recommended is inherently beneficial and should be invariably performed. Our results do, however, indicate that early anesthesia does not have to put the patients at additional risk as anticipated by previous studies3,4 and can be advantageous within specific time windows and with limited durations in certain patients with SE.


Ibuprofen is a nonsteroidal anti-inflammatory drug, and many of its similar class includes aspirin, indomethacin (Indocin), naproxen (Aleve), nabumetone (Relafen), and many others. This drug is used in moderate pain, fever, and inflammation, which is promoted by the release in the body of chemicals called prostaglandins. According to the IUPAC, it is (RS)-2-(4-(2-methylpropyl)phenyl)propanoic acid. The original synthesis of ibuprofen by the Boots Group started with the compound 2-methylpropyl benzene. Ibuprofen blocks the enzyme that makes prostaglandins (cyclooxygenase), resulting in lower levels of prostaglandins that help in reducing inflammation, pain, and fever. This review is focused on various chemical and functional properties and experimental studies of ibuprofen including various detection methods such as potentiometric, ultraviolet spectrophotometric, gas chromatography, high-performance liquid chromatography (HPLC), and reverse-HPLC which can also be used for the extraction, quantification, and quality analysis.


The purpose of this study was to explore China's supply chain integration developing process. We investigated integrative practice of China in recently 10 years. Separate three time periods, and explore evolution of integrative practice. Based on explorative results, further identify for China's supply chain integration developing process. The taxonomy approach is mainly methodology in this study.


The assessment of public policies is a step rousing interest both by comparison to the entire cycle of public policies, and related to the implementation of policies, especially seeing that the two steps were separately described in the specialty literature due to their specificity. The assessment assumes various actors, specific steps and sub-steps; it uses its own techniques, methods and tools. This specific framework of the assessment process will be followed at the level of this article and will be generically named the design of the assessment process. The design of assessment tries to define assessment related to the existence of assessment, its targets and functions, actors, steps and typologies. This study proposes to find the specificity elements of assessment and to outline what they have previously defined as being an evaluative design specific to local administration which can lead to good public policies as long as there is no assessment recipe.


Health is defined by the World Health Organization as a state of complete physical, mental and social well-being, and not merely the absence of disease. The present study aimed to know and reflect on the perception of the indigenous ethnicity Haliti-Paresí on the health-disease process. It is a research with a qualitative and ethnographic approach, in which data were collected in July 2015, through visits in the Wazare village and dialogue with the 34 residents, followed by the constitution of core meanings for data separation, according to their nature. The Paresí define health as the state of vitality in which there is energy to perform the basic activities, with food, hygiene and spirituality as determining factors. Negligence by the individual, climate change and higher forces establish the disease, with hantavirus being the main and most worrying. The health-disease process is based on the culture of this people, in which there is the figure of the shaman, elder or chief to reestablish the vital balance through rituals, offerings, teas and prayers, associated with Western medicine. There should be greater training of indigenous and non-indigenous professionals to provide comprehensive and effective assistance, as well as health education as a tool for disease prevention.


Objective To study the clinical characteristics,diagnostic and therapeutic methods of the orbital blowout fracture.Methods The data of the 89 patients with orbital blowout fracture confirmed by CT scan were analyzed.Results the causes of disease were hitting on the eyes (57.3%),car accidents(20.2%),kicking on the eyes(11.2%),hitting on the eyes by dull instruments(9.0%) and falling(2.2%).All patients had swollen and stagnant eyelids,different degrees of vision reduction,and some of them had big fracture areas with enophthalmos,strangulation of rectus lateralis muscle with limitation of eye movement,diplopia;hyphema,retinal turbulence,and macular hemorrhage et al were seldom observed.Conclusion The characteristics of orbital blowout fracture are very complicated so that it is easy to misdiagnosed,and CT scan plays an important role in diagnosis of orbital blowout fracture,and it is a useful standard to diagnose this disease.


This thesis reveals how eleven years at war and thirteen years of economic sanctions followed by invasion and occupation led to the degeneration of Iraq's health infrastructure and the health of a nation. It further argues that waves of internal and external displacement, omnipresent corruption, hollow state institutions, and the individual and collective trauma following years of exposure to extreme violence remain unaddressed. These trends have prolonged inertia and stifled attempts to rejuvenate Iraq's health system a keystone in the foundation for a country's recovery and in its healing from the visible and invisible wounds of the past.


Monte Carlo simulation (MCS) is applied to the estmation of illuminance distributions in infinitely long interiors which have visual obstructions and luminous surface ceilings. Although a number of lighting calculations by MCS have already been carried out in various interiors with point or linear light sources, such area sources as luminous surface ceilings and daylight through glass windows are rather common in many practical lighting designs. So far illuminance distributions have scarcely been calculated taking into account the interreflection of luminous flux between wall surfaces in the interior space, particularly in the complicated lighting interiors which are partitioned by many visual obstructions and have an asymmetrical luminous surface ceiling. The present paper compares illuminance distributions calculated by theoretical equations based on the contour integration method with those obtained by MCS in infinitely long concave interiors which have luminous surface ceilings of various shapes and four visual obstructions, and also describes the conservation law of photon bundles due to the interreflection between wall surfaces in these interior spaces. As a result, it can be concluded that MCS results of direct illuminance distributions agree with those obtained by the contour integration method and that the conservation law of photon bundles in the concave interiors with transparent visual obstructions holds well. Therefore, it seems that MCS technique for illuminance calculation is a very powerful tool in infinitely long concave interior spaces.


This article examines the representations of Ecuador's Oriente and its inhabitants in the exposition organized in Rome. At this event, objects collected by the religious communities from various missionary territories throughout the world were exhibited. In the case of Ecuador, the collection came from the Apostolic Vicariate of Mendez and Gualaquiza, where the Salesians were carrying out their ministry. The sample of cultural objects on display highlights how these indigenous groups were viewed and what role the Catholic Church had been assigned to play in religious, scientific, and cultural matters.


Focusing is on the needs of consumers of basic essentials marketing trends. This study explored the needs of consumers and consumer behavior analysis and prioritizes the factors that affect the process of finding the market's major tasks (Moon, minor, translated by Ardestani, 2005). This study aimed to evaluate the impact of packaging of the product on consumer willingness to buy gum industry. The present study was carried out on a sample of students of Islamic Azad University of Qazvin, about 24,000 persons. Using a simple random sample of 400 questionnaires were distributed among the students finally 376 valid questionnaires were collected. Finally, the researcher concluded that the functional characteristics of the product packaging have an impact on the willingness of customers to purchase it.


Nickel molybdate (α-NiMoO4) nanoparticles were prepared by a solution combustion synthesis (SCS) technique and, for the first time, were studied as a potential electrode material for supercapacitors. High specific capacitance (1517 F g−1) and energy density (52.7 W h Kg−1) were delivered by nano-α-NiMoO4 at a current density of 1.2 A g−1, due to the pseudocapacitive nature of the material.


The merits of studious men are to be estimated by the aids they have given to the advancement of science, or the literary monuments they have left with posterity; but if the public be gratified by their labours in these respects, readers are generally willing also to be told, who and whence they were.


Up to now, a number of existing methods have worked fairly well in the field of vehicle and license plate detection. However, those methods are still not sufficient enough for satisfying practical industrial demands in terms of efficiency and accuracy, exhibiting poor performances such as incomplete detection of license plated when multiple vehicles are contained in the target image, and poor vehicle recognition when illumination is inadequate at night. To solve these limitations, a novel end-to-end secondary detection network named ES-Yolov3-tiny is proposed in this paper. ES-Yolov3-tiny can improve detection efficiency and accuracy by virtue of the secondary detection technology, and detect multiple vehicles in the same target image with the help of the interested region extraction technology. Compared with other existing state-of-the-art methods, the experiments show that the proposed method has better accuracy and lower computational cost.


Erv1 (essential for respiration and viability 1) is a FAD-dependent sulphydryl oxidase with a tryptophan-rich catalytic domain. We show that Trp95 and Trp183 are important for stabilizing the folding, FAD-binding, and function of Erv1, whilst other four tryptophan residues are not functionally important.


The anatomical variation in meat quality traits was studied in pigs from various types (Belgian Landrace, French Landrace and Pietrain females (N = 47) and Pietrain males (N = 10) slaugh-tered in standard conditions) by measuring pH, colour (C) and waterholding capacity (WHC) at different anatomical locations of six muscles (Adductor, Biceps femoris, Longissimus dorsi, Rectus femoris, Semimembranosus, Semitendinosus). The average value of each trait was different from one muscle to another and the variation between muscles was different according to the trait (larger for C than for WHC or pH). Within each muscle, slight differences were also found between locations of measurement. The results suggest that the variation of any meat quality trait at a given anatomical level is explained both by the metabolic and functional hierarchy existing among the different muscles and by a specific factor resulting from the animal type (sex and genotype). The variation observed between the different muscle locations is very different from one animal to another, which suggests that the metabolic hierarchy is variable in pigs and depends upon the animal type. In order to find out reliable indexes for measuring overall meat quality, the report emphasizes the importance of studying the variation of anatomical origin (along the different levels of each major muscle) using techniques of anatomical topography based on the examination of serial cross- sections of muscles. loss factor (MS-Tester) were carried out 40 min, 3 h and 24 h post-mortem on the Semimembranosus and Longissimus dorsi of 295 commercial pigs. The meat quality index and a subjective score attributed to the ham were also taken into account. The validity of the dielectric loss factor was assessed by the number of detected PSE (Pale, Soft Exudative) samples characterized by a pH 40 (! 5.80 in one or both muscles). These results confirm the interest of measuring the dielectric loss factor three hours post-mortem (60-70 p. 100 PSE cases detected by the MS-Tester). Measurements performed 40 min and 24 h post-mortem are far less reliable. The dielectric loss factor is not correlated with the meat quality index. Its purpose is to detect PSE meats and not to predict the technological quality of meats. The Longissimus dorsi muscle seems to be the most appropriate for the light scatter measurements (FOP) 3 hours post-mortem. The subjective score is well correlated with the meat quality index (r = - 0.69) and better correlated than the latter to the other variables (except with pH 24). It involves an estimation of both the PSE status and the technological quality.


"HFW + hot stretch reducing + full body heat treatment + high temperature straightening" techniques were developed to produce BSG-80TT high collapse resistant casing. The Φ139.7mm×9.17mm BSG-80TT high collapse resistant casing was developed successfully through controlling geometric dimension accuracy,mechanical properties and residual stress. The test results showed that the BSG-80TT high collapse resistant casing is with good comprehensive performance,such as high strength,high toughness and high collapse resistance,and the collapsing strength is beyond specified value in API TR 5C3 more than 50%.


Objective To assess the results of combinded Salter' innominate osteotomy and femur osteotomy on developmental dysplasia of the hip(DDH).Methods Salter' pelvis and femoral osteotomies were carried out on 59 cases DDH in our hospital.Acetabulum head index(AHI),centre edge(CE),acetabulum index(AI) and femur head diameter rate(FHDR) in DDH and healthy hip were measured respectively and the results of the surgery were also assessed.Results In follow-up duration of 1~5 years,the AHI,CE,AI and FHDR were evidently developed after treatment,especially in 2~3 years postoperatively.The results of operation were excellent in 66.1%(39/59),good in 27.1%(16/59),fair in 6.8%(4/59),and the excellent and good rate was 93.2%.Conclusions Combinded Salter innominate osteotomy and femur osteotomy with torsion were credible treatment to developmental dysplasia of the hip.


Obesity affects a significant number of Americans and greatly increases the risk of developing cardiovascular disease, type‐II diabetes, fatty liver disease, and certain cancers. Understanding how obesity is regulated opens up new avenues of pharmacological interventions to treat obesity, concurrently reducing the risk of co‐morbidities. Mice lacking the broadly expressed enzyme Nocturnin (NOCT) are resistant to diet‐induced obesity and other studies have observed a role for this enzyme in regulating intestinal trafficking of dietary fats and promoting adipogenesis. We have characterized human NOCT and determined that it represses the activity of reporter RNAs in tethered function assays promotes decay of reporter RNAs in vivo. These observations are consistent with a proposed function for NOCT in RNA decay and suggest that there may be a novel pathway that regulates lipid metabolism by targeting mRNAs for degradation. Though the broader physiological effects of gene deletion of NOCT have been described, discovering its molecular function remains an important goal. We have utilized structural and approaches to determine the first crystal structure of the human homolog of NOCT to aid in elucidating its catalytic mechanism. Additionally, we have developed cell‐based assays that will be used to study NOCT function and analyze the effects of active site mutants. These studies describe the structure and activity of human NOCT and provide the foundation for characterizing this enzyme as a potential drug target for obesity and related co‐morbidities.


A kind of nonautonomous system of two predator populations and one common prey population is considered. In the system, the prey population can choose their own refuges to avoid being preyed by its natural enemy. The prey species can diffuse between the interior and exterior of the refuges. It is proved that the system can be persistent under certain conditions and that if the system is periodic,it has a strictly positive orbit, which is globally and asymptotically stable under the appropriate conditions.


Maize has attracted the attention of local governments due to its high yield potential and economic prospects, but the strategic value of this commodity has not been specific to particular locations. Therefore, this study aimed to assess degraded land suitability and determine the regional comparative advantages for maize development in the Gorontalo sustainable agriculture areas. The suitability class was assessed using Automatic Land Evaluation System software, while comparative advantages were determined using input-output and regional analysis. The input-output analysis was based on maize farming data from interviews with 80 farmers. This study also employed location quotient, specialization index, and localization index analyses based on maize, rice, and soybean production data for 2014, 2016, and 2018. The results showed that land degradation caused by soil erosion was dominated by moderate, heavy, and very heavy categories. Most of the actual land suitability for maize was classified as marginal suitable (S3) but became very suitable (S1) and moderately suitable (S2) after the limiting factors were improved. Furthermore, maize was profitable for the land suitability classes of S1, S2, and S3, and the commodity was most concentrated in Mootilango District. Based on the results, land management recommendations followed a pattern of recommendation I > II > III > not recommended.


There have been numerous technological advancements in the field of agriculture in recent years. One of which is hydroponic farming - a soil-less method of cultivating crops using nutrient enriched water. While hydroponic farming has numerous advantages, the methods are more complicated than those of conventional farming. Possibilities of system failure are higher due to added factors of growing. An Arduino-based automated data acquisition system (DAQ) was developed to easily diagnose and troubleshoot the system. This paper presents the design, construction, and calibration of the DAQ system that can log six different growing conditions - air temperature, relative humidity, water temperature, water level, pH level, and light intensity. Results showed that the sensors were properly calibrated and accurate based on standard instruments. Additionally, plot curves of each parameter were generated from the collected data in the system.


This study aims to find out the problems of education and learning in SMA Negeri 12 Kerinci and SMA Negeri 7 Kerinci. The research used is qualitative research with case study method. Data collection techniques in the form of observations, interviews, and documentation. The results of the study can be concluded that SMA Negeri 12 Kerinci experienced educational and learning problems, namely the lack of facilities and infrastructure of science laboratories, lack of computers for the National Computer-Based Examination (UNBK), and the lack of activeness of students in the teaching and learning process. SMA Negeri 7 Kerinci has problems with education and learning, namely the lack of management of school facilities and infrastructure and the lack of learning media in the teaching and learning process.


The objective of this research is to examine the micro-machining responses of a hierarchical three-phase composite made up of micro-scale glass fibers that are held together by an epoxy matrix laden with nano-scale graphene platelets. To this end, micro-milling experiments are performed on both the hierarchical graphene composite as well as on a baseline two-phase glass fiber composite without the graphene additive. The composite microstructure is characterized using transmission electron microscopy and scanning electron microscopy methods. Tool wear, chip morphology, cutting force, surface roughness and delamination are employed as machinability measures. In general, the tool wear, cutting forces, surface roughness and extent of delamination are all seen to be lower for the hierarchical graphene composite. These improvements are attributed to the fact that graphene platelets improve the thermal conductivity of the matrix, provide lubrication at the tool-chip interface and also improve the interface strength between the glass fibers and the matrix. Thus, the addition of graphene to a conventional two-phase glass fiber epoxy composite is seen to not only improve its mechanical properties but also its machinability.Copyright © 2013 by ASME


Molecular organic semiconductors and nanometer size particles are two new classes of functional materials allowing fabrication of electronic devices on low-cost and large area substrates. Patterning these electronic materials requires the development of unconventional techniques, and the scientific understanding behind the manufacture processes. We introduce the first-generation Molecular Jet (MoJet) printing technique for vacuum deposition of evaporated thin films and apply it to the fabrication of high-resolution pixelated (800 ppi) molecular organic light emitting devices (OLEDs) based on aluminum tris(8hydroxyquinoline) (Alq3), and the fabrication of pentacene based organic field effect transistors (OFETs) with narrow channel (15 gm) and asymmetric silver/gold contacts. Patterned printing of both organic and metal films is demonstrated, with the operating properties of MoJet-printed OLEDs and OFETs shown to be comparable with the performance of devices fabricated by conventional evaporative deposition through a metal stencil. This MoJet printing technique is reconfigurable for digital fabrication of arbitrary patterns with multiple material sets and a high print accuracy of better than 5pm, and scalable to large area substrates. Analogous to the concept of "drop-on-demand" in Inkjet printing technology, MoJet printing is a "flux-on-demand" process and we show it capable of fabricating multi-layer stacked film structures, as needed for engineered organic devices. We present the concept and the applications of the second-generation MoJet printing technique. Using this technique, we demonstrate patterned molecular organic semiconducting thin films directly printed by a three-step local evaporative deposition, in conjunction with using the HP thermal InkJet printing technology. This MoJet printing technique can be applied to pattern solution-processable molecular organic thin films, providing flux-on-demand in an ambient environment. We develop an Inkjet assisted micro-contact printing technique for the patterning of colloidal semiconductor nanoparticles. Active OLEDs incorporated with a uniform thickness layer of colloidal nanoparticles are fabricated by using this Inkjet printing plus stamp transferring technique. The material usage efficiency is largely boosted. To our knowledge, these three novel patterning techniques presented in this study provide for the first time unprecedented capabilities for manufacturing organic and nanostructured electronic devices. Thesis Supervisor: Vladimir Bulovid Title: Associate Professor of Electrical Engineering and Computer Science


Purpose - The relevance of economic freedom in influencing bank risk has not been adequately addressed in the literature. In this connection, employing bank-level data for 2000-2012, the article examines the impact of economic freedom on risk-taking by MENA banks. Design/methodology/approach - Given the cross-sectional, time series nature of the data, we employ panel data techniques to explore this issue. In addition, we examine the robustness of the results using instrumental variable techniques. Findings - The findings appear to suggest that economic freedom exerts a significant and non-negligible impact on bank risk-taking. Among the sub-components of economic freedom, it is observed that higher levels of both business and monetary freedom increase variability of profits and thereby, raise the risk appetite of banks. Risk taking by banks appears to be reliably lower after the crisis than in the period prior to it, although there was a substantial increase in bank risk taking during the crisis. Originality/value - To the best of our knowledge, this is one of the earliest studies to explore the interlinkage between economic freedom and bank risk-taking for MENA banks.


Wireless Sensor Networks (WSNs) are the networks of sensing devices called nodes, which are connected without any sought of wires. For the sake of communicating the information from nodes to the Base Station (BS), node should posses a communication unit, it is very necessary for a power supply unit to drive the communication unit. The protruding issue in any WSN is with the power consumption and Energy constraints. Senor node consumes a huge amount of power for the transmission of sensed real time information. For certain applications like in remote areas or in military applications, replacement or recharging of batteries at sensor nodes will be very challenging, where human intervention is difficult. In order to find a better solution for this problem we worked on the existing cluster based routing protocol- LEACH and designed a novel algorithm called Specialized Power (SP-LEACH), which can minimize the overall power consumption for communication in the network confirming uniform load amongst nodes which results in getting an improved energy efficient network. In turn it also enhances the life time for WSNs. Newly developed protocol, SP-LEACH is been subjected to a detailed comparison with the existing LEACH protocol and those systematic comparisons and the results obtained are clearly explained in this paper.


Mo v 2 (O) 2 (μ-O) 2 complexes are known to be distorted asymmetrically when optically active ligands are coordinated. The distortion of the W v 2 (O) 2 (μ-O) 2 complexes has been compared with that of the Mo v dimers. Extent of the asymmetric distorsion is found to be smaller for the W v 2 complexes than for the Mo v 2 ones, as evidenced by the following three facts. (i) The various torsion angles of the new complex [W 2 (O) 2 (μ-O) 2 (μ-R-pdta)] 2− (R-pdta = (R)-propylenediamine-N,N,N',N'-tetraacetate (4-)) as determined by the X-ray crystal structural analysis are smaller than the corresponding angles of the Mo 2 complex. Crystals of Ba[W 2 (O) 2 (μ-O) 2 (μ-R-pdta)]6H 2 O(C 11 H 26 N 2 O 18 BaW 2 ) are triclinic, space group P1, with a = 7.625 (1) A, b = 11.882 (2) A, c = 7.133 (1) A, α = 98.623 (9)˚, β = 94.288 (9)˚, γ = 116.922 (8)˚, V = 562.2 (1) A 3 , and Z = 1. The structure was solved by use of 4895 unique reflections with |F 0 |>3σ(F 0 ) to give R = 0.036. (ii) Circular dichroism spectra of the W 2 -R-pdta complex show peaks with magnitudes smaller than those of the corresponding peaks of the Mo 2 -R-pdta complex. (iii) Dynamic 13 C NMR analysis of the asymmetric inversion (Δ⇄Λ) of the W 2 -edta (edta = ethylenediaminetetraacetate(4-)) gives k = (2.87±0.06) × 10 2 s −1 (25˚C), ΔH: = 36• ± 2 kJ mol −1 , and ΔS: = 53 ± 5 J K −1 mol −1 . The ΔH : is smaller than the one for the inversion of the Mo 2 -edta complex, suggesting smaller amplitude of the inversion. The higher extent of the covalent character of the W v 2 complexes may account for the observations


With the increasing heights of super‐tall buildings, the natural frequency of these structures approaches the predominant frequency of winds, causing the structures to be more sensitive to wind load. For the safety and economy of these structures, the formulation of a reasonable wind‐resistant design is crucial. In this paper, an optimal design of toggle‐brace damper systems for super‐tall buildings using a damping ratio limit method is presented to obtain the optimal placement, number, and damping coefficient of toggle‐brace dampers under different constraints. The constraints include the additional damping ratio under a 50‐year return period wind, the maximum power of the damper under a 50‐year return period wind, and the maximum output force of a moderate earthquake. The toggle‐brace damper systems improve the structural performance. Hence, the structural components produce design redundancy, which can be optimized using the sequential quadratic programming (SQP) algorithm and a multi‐grade constrained optimal design method to further improve the economic benefits of the structure. Based on the combination of the optimal design method of toggle‐brace damper systems, SQP algorithm, and multi‐grade constrained optimal design method, an integrated optimal wind‐resistant design for toggle‐brace damper systems is proposed. To demonstrate the effectiveness and applicability of this design, a 245‐m super‐tall building is employed as an engineering case.


Polyelectrolyte multilayers (PEM) loaded with bioactive molecules such as proteins serve as excellent mimics of an extracellular matrix and may find applications in fields such as biomedicine and cell biology. A question which is crucial to the successful employment of PEMs is whether conformation and bioactivity of the loaded proteins is preserved. In this work, the polarized attenuated total reflection Fourier transform infrared (ATR-FTIR) technique is applied to investigate the conformation of the protein lysozyme (Lys) loaded into the poly(L-lysine)/hyaluronic acid (PLL/HA) multilayers. Spectra are taken from the protein in the PEMs coated onto an ATR crystal during protein adsorption and desorption. For comparison, a similar investigation is performed for the case of Lys in contact with the uncoated crystal. The study highlights the presence of both "tightly" and "poorly bound" Lys fractions in the PEM. These fractions differ in their conformation and release behavior from the PEM upon washing. Comparison of spectra recorded with different polarizations suggests preferential orientation of alpha helical structures, beta sheets and turns in the "tightly bound" Lys. In contrast, the "poorly bound" fraction shows isotropic orientation and its conformation is well preserved.


The lips are a fundamental anatomic unit that provides biological aesthetics and function to the human body. Lips can be affected by different pathologies which may result in signs and symptoms affecting patients' health, but if dentists know enough about lips structure and function they would positively affect the patient through the diagnosis and treatment plan. Aiming to establish the grade of knowledge of dentists working in private services a survey was performed to 10% of a representative sample of private practice dentists from Merida, Venezuela. It was an exploratory research within a quantitative approach and a non-experimental transversal design. Results were obtained by using descriptive statistics and the data were processed with SPSS (version 20) software. Those results indicated, according to the average of right answers separately (60%), that dentists working in private services in the aforementioned municipality show high knowledge about lip pathologies.


Recent study on Liu Hsieh's Wen-shin-diao-lung has been focusing on the issue of "literary pivotal." This paper presupposes the idea that approaching the paradigm of "literary pivotal" from the angle of "cheng-pien" of literary style does not aim to reexamine the predecessors critically, but to reflect on the paradigm of Liu Hsieh's five essays concerning "Wen-yuan-lun" which include the essay titled "literary pivotal." Based on this point, this paper will discuss the first three essays of "Wen-yuan-lun," exploring the paradigm value of "tao, sheng, wen"-the so-called "three unities" inherent in the three essays and, meanwhile, offering the literary criteria Liu Hsieh hoped to construct on his "normal paradigm." Also, the fact that "Cheng Wei" and "Pien Sao" were categorized and included in the dimension of Liu Hieh's "Wen-yuan-lun" has been arousing diversified and critical discussions. This paper would like to reflect on the creativity and evolution of its "cheng" and "pien" on the foundation of Liu Hsieh's "Tsung Jing." This paper proceeds to conclude that the two essays-"Cheng Wei" and "Pien Sao"-form and establish a "cheng-pien" relation with "Tsung Jing." Based on this triangle relation, this paper re-examines the "normal paradigm" and "changing paradigm" inherent in Liu Hsieh's "Wen-yuan-lun.".


AECS has 25 years of experience in liquid-liquid chromatography. Instruments dedicated to CBD, THC, CBG, CBDA, etc, sold Europe and Americas for research and process.


Cultural spaces play a key role within our environment and our heritage and are not only important for us here at home but attract visitors from all over the world and thus need to satisfy their sponsors and end users. The research will explore project success by looking at three cultural institutions to understand the importance of how the project mission captures the values set out through the integrity of the concept1. The focus of the analysis will concentrate on the quality of conception and realisation of the projects. The emphasis will initially be looked at from the architects and space planners view point as they are ultimately the 'integrators' of the multiple requirements expressed by different stakeholders.


(57) Abstract: A syringe needle disposable at both ends pointed has a needle hub small needle cannula is permanently fixed, the needle hub and the dose setting and injection mechanism, It may be mounted on a syringe with a cartridge containing the liquid medicine to be injected subcutaneously in the human body. The needle hub, the safety shield is guided on the outer surface of the needle hub is mounted. Safety shield is biased in a direction as away from the needle hub by position by a spring between the needle hub and the safety shield. Safety shield has a plurality of projections guided in a guide track on the outer surface of the needle hub. Guide track, by the spring, during injection is moved safety shield toward the needle hub after injection is moved away from the needle hub, the sting of accidental needle safety shield covers the needle cannula as it will be locked in an irreversible position for preventing are designed.


Glucocorticoids are effective in the treatment of inflammatory bowel disease (IBD),especially for controlling acute exacerbation.Nevertheless,some patients show poor response even being glucocorticoids-resistant.Some progressions have been made on the molecular mechanisms of glucocorticoids resistance,mainly including increased expressions of multidrug resistance gene 1 and glucocorticoid receptor β,abnormal activation of proinflammatory transcription factors, macrophage migration inhibitoiy factor,and Th17/Th2 cells etc.In addition,there are some clinical studies analyzing the predictors of treatment failure of glucocorticoids in IBD.We summarized these studies,hoping to formulate more reasonable therapeutic regimens for the benefit of patients.


A new report analyzing the U.S. National Cancer Institute Surveillance, Epidemiology, and End Results (SEER) database suggests that the incidence of de


Schistosomiasis is a major disease of public health in human. Patterns on immune response, worm recovery, in vitro antischistosomal bioassay screening (cercaricidal killing in vitro of Schistosoma mansoni was observed). In vivo Mice were infected by injection of 100 S. mansoni cercariae/mouse and treated by oral administration with crude extract, MeOH, ethyl acetate (EtOAc) and butanol (BuOH) Carica papaya fruits (4g/kg) start from 7th day p.i. to the end of experiment and a treatment control of 500 mg/kg of Praziquantel. Various concentrations of plant extracts were used in cercaricidal assay. Both crude extract and EtOAc showed significant dose-dependent percentage worm load reduction (P<0.001). Carica papaya, showed highly reduction in worm counts (60.3% and 68.2%) while Praziquantel (92.8%), elevated immune responses and least time in destroying cercariae. The highest significant reduction in dead ova (P<0.001) was observed in group treated with EtOAc extract. The level of IgG1 and IgG2 was significantly reduced (P<0.001) than in groups treated with C. papaya crude extract, EtOAc extract or PZQ as compared to levels in untreated infected mice. While the level of IgG1 and IgG2 was insignificantly reduced in groups treated with MeOH extract or BuOH extract as compared to levels in untreated infected mice. It was concluded from the results that the antischistosomal efficacy of the extracts was dependent being more potent in reducing both the worm burden and tissue egg load. The antishistosomal effect of C. papaya extracts was significantly higher in group treated with EtOAc extract. These findings supporting the potential use of C. papaya extracts in the management of schistosomiasis.


Poor separation of tar and ammonia and high oil content in ammonia not only block ammonia spray,but also affected cooling effect of coal gas. Based on site investigation,the reasons that cause poor separation of tar and ammonia and high oil content in ammonia were analyzed,specific measures of Valin Coking Plant took in system optimization were also discussed to effectively reduce oil content in ammonia..


J 2022 marks the one-year anniversary of ACS Bio & Med Chem Au, ACS's premier open access journal for medicinal, biochemical, and biomedical content. I want to thank Professor Shelley Minteer, the editor of the nine gold open access journals, Amelia Newman, our managing editor, the staff at ACS Publications, our Associate Editors Professors Afsaneh Lavasanifar and Stuart Conway, and, of course, all who have supported the journal by submitting and reviewing manuscripts. We ask our community of scientists to help make ACS Bio & Med Chem Au one of the very best journals in the field of biological and medicinal chemistry by submitting their very best work and by holding manuscripts to very high standards of rigor and impact during the review process. In another editorial to be written in the coming few months, Professors Afsaneh Lavasanifar, Stuart Conway, and I will review the type of content that is both acceptable and unacceptable for the journal and will provide standards to instruct reviewers on how best to review manuscripts. Our first anniversary issue of the journal brings a mixture of perspectives, reviews, and research articles. Given the ongoing COVID-19 pandemic, we are pleased to present an article from the laboratories of Sanchita Hati and Sudeep Bhattacharyya from the University of Wisconsin, Eau Claire entitled "PreExisting Oxidative Stress Creates a Docking-Ready Conformation of the SARS-CoV-2 Receptor-Binding Domain". Using molecular dynamics simulations, the authors determined that the redox state of the receptor-binding domain of the SARSCoV-2 spike protein and the peptidase domain of the human cell surface receptor angiotensin converting enzyme II affect the structural complementarity between the two binding partners via large conformational changes, with disulfide bonds inducing a ready-to-bind conformation. They propose that pre-existing oxidative stress, prevalent among those at high risk for infection and associated mortality, elevates the binding affinity of the spike protein for the human receptor (DOI: 10.1021/acsbiomedchemau.1c00040). We also thank the authors for providing the cover art for this issue of the journal. A second research article, from the laboratory of Bo Liedberg at the Nanyang Technological University in Singapore, is entitled "Amphiphilic Membrane Environments Regulate Enzymatic Behaviors of Salmonella Outer Membrane Protease". In this work, the authors use the Salmonella enterica outer membrane protease E (PgtE) as a model to understand the specific protein−lipid interactions that drive the conformational plasticity and function of integral membrane proteins. PgtE is involved in tissue infiltration and the survival of the organism and plays an important role in bacterial resistance against innate and acquired immune defenses of infected mammals. PgtE requires the binding of lipopolysaccharide as a cofactor in its reaction. The authors find that PgtE exhibits hysteretic enzymatic behavior in its detergent-stabilized form and in the outer membrane-embedded native state in live bacteria, displaying a pronounced lag phase before achieving steady state. In addition to characterizing the protein's activity under several environmental conditions, the authors show that when the protein is reconstituted in a phospholipid bilayer composed of 1-palmitoyl-2-oleoyl-glycero-3-phosphocholine, PgtE no longer requires lipopolysaccharide as a cofactor (DOI: 10.1021/acsbiomedchemau.1c00027). A third research article, from the laboratory of Krishna Mohan Poluri at the Indian Institute of Technology Roorkee, is entitled "Elucidating the Eradication Mechanism of Perillyl Alcohol against Candida glabrata Biofilms: Insights into the Synergistic Effect with Azole Drugs". The authors had as an overall goal to develop new and novel treatments against the genus Candida, which are clinically the most prominent human fungal pathogens. Essential oils, many of which are derived from terpenes, have been known for some time to exhibit wound-healing, antiproliferative, immune-modulatory, antiaging, and hypoglycemic activities. In this study, the effect of the terpene perillyl alcohol on C. glabrata was investigated. The authors found that perillyl alcohol inhibits the growth of the organism and eradicates its biofilms. This effect was mediated through multiple pathways, including, among others, by reducing carbohydrate and eDNA content in the extracellular matrix, by affecting mitochondrial activity and inducing cytochrome C release from mitochondria, and by inhibiting DNA replication and progression to S-phase in the cell cycle. Moreover, the natural product acted synergistically with azolecontaining drugs such as miconazole (DOI: 10.1021/ acsbiomedchemau.1c00034). Five additional contributions in the first issue of Volume 2 of ACS Bio & Med Chem Au are part of a virtual issue focused on Radical S-adenosylmethionine (SAM) enzymes in honor of a pivotal bioinformatics paper published 20 years ago that established that these enzymes constitute a superfamily. A separate editorial that describes this superfamily in more detail is forthcoming. In short, this superfamily is arguably the most functionally diverse and one of largest, growing from about 600 constituents in the initial bioinformatics study to about


A general method to quantify the thixotropic behavior of systems with very low thixotropy is proposed. The areas enclosed by the rheograms tau = f(gamma) must be fitted to functions with well-determined boundary conditions. From these equations the corresponding thixotropic areas are obtained, together with the theoretical area enclosed by the rheogram corresponding to the maximum rheodestruction. The proposed method is applied to high viscosity sodium (carboxymethyl)cellulose gels.


Matrix metalloproteinases (MMPS) are a family of zinc (Zn)- a major role in the remodeling of the development of atherosclerosis. has a role in early plaque rupture and functional polymorphisms have been The aim of this work is to ymorphism of interstitial collagenase gene in diabetic patients with and without Coronary Artery to investigate whether this polymorphism is associated with Subjects and methods: This study into two groups; 28 patients with associated CAD. Type 2 diabetic


PLEASE DELETE ABSTRACT # 10800 17:010801Boiling heat transfer to isopropanol from a steam-heated chrome-plated Cu tube 0.375 in. in dia. was increased as much as four times the normal peak heat flux by the application of up to 3,500 volts d-c between the liquid and the tube. The heat transfer coefficient at 3,500 volts and a DELTA T of 128 deg F was 3,120 Btu/hr sq.-ft- deg F. The process completely eliminated film and transitional boiling above 500 volts, and the boiling is nucleate over the entire range of temperature difference covered (40 to 180 deg F). This large effect of voltage appears to involve a condenser effect which destabilizes the vapor space between the liquid and the heat transfer surface and is not due to dielectrophoresis in a convergent field. The results obtained substantiate the theories of surface wetting during transitional boiling. (auth)


The Journal of Graph Theory (JGT) lost one of its most helpful and enthusiastic editors in the untimely passing of Tory Parsons on 2 .4pril 1987. Amongst his other attributes, he was totally unsurpassed in his reliability as a referee for JGT. He always analyzed each paper sent to him in detail; he simplified proofs, clarified concepts, suggested new lines of research to authors, and with his remarkable breadth of knowledge was often able to provide exact references to the literature where either some theorems of the authors of some similar results had already been published. Tory was tapped for administrative duties even while still a graduate student at Princeton when he served as an assistant dean in the graduate school during the middle one of the three years which elapsed between his B.A. and his doctorate. In addition, he served on many departmental and university committees at both Pennsylvania State University and California State University, Chico. It was this time consuming selfless behavior which held down his list of publications to forty papers. Our paths crossed many times. We first met at Bowdoin College in the summer of 1971 at a national conference on combinatorics. We both attended the leap-year meetings in Kalamazoo, "International Conference on the Theory and Applications of Graphs," in 1976, 1980 and 1984. the Graph Theory Seminar in Oberwolfach in 1973, and the Seventh British Combinatorial Conference at Cambridge University in 1979. During these events, I found him to be a gifted lecturer. My most memorable meeting with him, however, was not at a conference or a university, but in his home. As it happened one Saturday afternoon in the Spring of 1987, I was driving through State College on the way back to Ann Arbor (from New Jersey) and was invited by Tory and his wife Noelle to spend the night. This event made possible a six-hour nonstop (well. almost) spirited conversation on graph and combinatorics. The astounding depth and breadth of Tory's knowledge of graph theory which was so evident in that marathon session made an indelible impression on me that 1 have never forgotten. All of us at JGT will miss Tory Parsons.


M. I. Gekhtman* and M. Shmoish Department of Theoretical Mathematics The Weizmann Institute of Science Rehovot 76100, Israel ¢ Dedicated to M. Fiedler and V. Pt~k. Submitted by Nicholas J. Young ABSTRACT Conditions for inverting H-Bezoutians of nonsquare matrix polynomials are studied. Necessary and sufficient conditions for invertibility of the Anderson-Jury Bezoutian are obtained. An application to the inversion of block Hankel matrices is


Objective To investigate the influence of radiotherapy for nasopharyngeal carcinoma on middle ear functions and to find an effective management.Methods The development of secretory otitis and the change of middle ear pressure in 163 patients(326 ears) with nasopharyngeal carcinoma were observated before and after radiotherapy.Results Incidence of secretory otitis resulting from radiotherapy for nosopharyngeal carcinoma was 41.6%(102/245 ears),47.1%(48/102 ears) of them occured in 6 monthes after radiotherapy.The direct irradiation demage and the rising negative pressure of middle ear before raditherapy may be closely associated with it.Conclusion The secretory otitis is one of the causes which influence middle ear functions after radiotherapy for patients with nasopharyngeal carcinoma.Improvement of radiotherapy technique,effective drug and tympanum intubation may be helpful.


We investigated the prevalence of infectious duck diseases using 156 ducks reared in 18 farms of western Gyeong-nam province. As a result, duck viral hepatitis (12.8%), colibacillosis (7.1%), and fungal disease (9.0%) were detected. However, avian influenza and riemerellosis were not detected. During autopsies, we could grossly observed red swollen liver (12.8%), petechial or ecchymotic hemorrhage on liver (11.5%), and fibrinous perihepatitis (9.0%). Gray-white necrotic spot (23.1%), swollen spleen (22.8%), swollen kidney (20.5%), hyperemia or hemorrhage on tracheal mucous membrane (8.3%), and nodule in long or air sac (9.0%) were also found.


We sought to analyze key factors that influence the management of lateral skull base defects and implement an algorithm to improve outcomes of reconstruction.


MPEG-4 provides coding based on content. Before coding, each frame in video sequences needs to be divided into VOP (video object planes). Extraction of moving object is the principal problem. An extraction algorithm of video object based on Blackfin 533 DSP is proposed in the paper. The four order statistics of five frames difference are used to automatically separate the motion region from background, and to extract binary mask of moving object, and then to further use morphologic method to fill the gained binary mask. As revealed by experiments, automatic extracting of moving object can be realized easily through this method to facilitate the real-time image management.


A new series of N-acyl-N'-(3-chloro-4-fluorophenyl)thioureas have been prepared in excellent yield by the reaction of acylthiocyanates and 3-chloro-4-fluoroaniline under solid-liquid phase transfer catalysis using PEG-400. All synthesised compounds were screened against Escherichia cull and Staphylococcus aureus in DMF for evaluating their antibacterial activity. 2d, 2c, 2f and 2g showed good activity at 50 μg/ml dilution.


Traditional OFDM systems present some embedded features that may be exploited in order to intercept the wireless transmitted signal. However, such a possibility is not accepted in military applications where security is a very important issue. Cyclic prefix is one of the most obvious OFDM parameters that induce cyclostationarity features. Aiming to suppress these features, some classical solutions in literature propose to entirely remove the cyclic extension so that additional processing is needed to eliminate the inter-symbol interference. In this paper we propose two techniques that, when combined, allow to eliminate cyclostationary and spectral features of the OFDM waveform, while maintaining the cyclic prefix advantages. The cyclic-prefix size in each OFDM symbol is varied pseudo-randomly so that cyclostationary features are suppressed. Moreover, a pseudo-random frequency jitter is introduced to the carrier frequency in order to mask subcarrier spectral lines. Once these techniques are applied, the designed system is said to generate a low-probability-of-intercept waveform. Finally, performance in multipath channels is investigated and shown to be effective.


The Bathurst electorate is one of the state's most diverse districts. It takes in the major centres of Bathurst, a visitor mecca for its attractions, history and education, and the traditional coal mining area of Lithgow, as well as surrounding smaller towns, villages and farms.


Definitive attitude solutions are supposed to be the most accurate possible. For the Earth Radiation Budget Satellite (ERBS), this has been accomplished by using gyro rates to transform many nonsimultaneous observations to a common time point and then averaging to reduce the effects of observation noise. Rate quality is critical to realizing improved accuracy with this method. Gyro deterioration, which shows up as large observation residuals and discontinuities between contiguous batch solutions, now discourages using the batch approach for ERBS. To address this problem, a simple Kalman filter is tried in place of the batch estimator. The filter works well as long as the attitude is completely observable. During periods without Sun coverage, however, the extrapolated yaw may diverge and then change abruptly when the Sun returns to the sensor field of view. Causes of this behavior are discussed, and some solutions are tried that address the observability aspect of the problem.


The foundation of an effective design methodology of groupware technologies traditionally hinges on the collection of the "correct" requirements at the early stages of the development life cycle in order to inform their design. By collecting the "correct" requirements, the design and implementation of these technologies are deemed to more adequately support the needs of their target users' everyday work practices. Being able to reveal such needs is contingent on a theory's capability to "model" users' contexts at design time and thereby predict possible outcomes of the design at use time. The meaning of these technologies' usefulness is defined at the design and implementation stages. Although the research and system development undertaken here initially followed a traditional design approach, the system's eventual deployment revealed that a set of more complex issues affects how users judge "usefulness."
This dissertation work addresses this issue by proposing an alternative perspective in which various possible meanings of the usefulness of a technology co-exist and are constantly being negotiated and co-constructed by the groups involved in the design, implementation, deployment, and use of a technology. Because usefulness is subject to different interpretations, the acceptance of the technology by a particular group will depend on the extent that the sociotechnical structures embedded in technology and those that are part of the use context can be integrated into one another. In other words, this work is not simply about "the impact of " a technology on a particular use context or by, the same matter, "the impact of" of a context on a particular technology, but how they constitute one another. It thus proposes this alternative framework for understanding and analyzing the usefulness of a technology, which rests on the accounts of the different social groups who participate in the design and use of the technology, the various sociohistorical contexts in which the technology is employed, and the different attributes of the technology.
To this end, this dissertation research studied the design and deployment of a social network based system, Web2gether. This system was intended to support the development of social networks among caregivers in special education while simultaneously utilizing these social networks to make recommendations for educational resources and information that users seek. Web2gether is a web-based hybrid recommender and collaborative system. This research employed the sociotechnical design circle as its design method, and has analytically integrated three major theoretical constructs—namely, social construction of technology, theory of structuration, and sociohistorical activity theory—in a coherent framework for the examination of technology design and deployment processes.


In 1993, the effects of fibrates in lowering serum alkaline phosphatase (ALP) was shown for bezafibrate (BF) to be the result of hepatic, rather than bone or intestinal, isoenzymes.1 These initial observations led to the suggestion that fibrates might be beneficial for patients with an elevated ALP and cholestatic liver disease. Since then, several dozen case reports and pilot studies have demonstrated the efficacy of fibrates in reducing serum biomarkers of cholestasis and liver function abnormalities in patients with primary biliary cirrhosis (PBC) or primary sclerosing cholangitis (PSC) and incomplete responses to ursodeoxycholic acid (UDCA) monotherapy (Tables 1 and and22).


This paper presents an algorithm to trace discrete straight lines in regular grids of any dimension. Most known line tracing algorithms have been developed in Z/sup 2/ and Z/sup 3/ orthogonal grids. The contribution of this paper is the definition of a method to trace lines in nonorthogonal grids in any dimension. This method is not restricted to being used with a specific grid connectivity as other widespread methods are. Good performance can be achieved because only additions are used during line tracing.


The next generation of radiobiology research requires increasingly more complex radiation sources to address questions ranging from the effects of space‐based radiation to the influence of dose rate on biological systems. The Idaho Accelerator Center (IAC) has developed a radiobiology research facility to address some of these questions. The irradiation challenge is to deliver stable and reproducible conditions of high dose rate with well‐controlled beam uniformity, dose, and dose rate under controlled temperature. In this work, we used a 25 MeV modified medical grade linear accelerator (LINAC) to obtain a high and adjustable electron dose rate. To overcome electron beam drift we used a collimator that both assisted the LINAC operator to steer the beam and ensured that regardless of beam drift, only the fixed collimated beam would irradiate the specimens. In addition, we utilized a beam flattener to keep the beam variation as low as 3% at 2.5 cm from the beam's center, and 1% variation between the simultaneously irradiated sample tubes. We also demonstrated that a segmented Faraday "cup" (FC) array provides a useful real‐time beam scanning and monitoring system, and is promising for implementing real‐time dosimetry and control.


The city of San Diego - faced with a flow of almost 100000 tons/year of yard trimmings - ran a pilot to learn how to best modify its materials handling practices and staffing requirements, and to assess markets.


After the stage of pointlike target tracking, the tracker comes to the stage of area target tracking. This paper considers the situation in which the FLIR image contains a number of targets. The targets are compact. The image segmentation is achieved by considering not only the global gray-level distribution but also the spatial distribution of target pixels. After the global gray-level statistics in the whole image, a recursive merging algorithm, a hierarchical clustering on the gray level and spatial position, is applied to segment the image into a multiple gray-level image. To make full use of the whole scene scan, a four direction code method is used to depict the edges of target regions. And to save more execution time, the useful features, including structure feature and geometry feature, are calculated by the four direction code expression at the same time. Thus the target edge description and the useful features calculation are finished in the same whole scene scan of the segmented image. A changing index table which describes targets and their features within the segmented image is set up. The index table is updated at each scene to depict the changing content of the image. During the time in which the image gets into a comparable stable state, a target recognition procedure may be applied to find the interested target, and the threatening value of each target is considered. An adaptive gate is assigned to each interested target.


A fast and reliable image enhancement technique based on the fuzzy relaxation algorithm is proposed. Different orders of fuzzy membership functions and different rank statistics are used to improve the enhancement speed and quality, respectively. The proof of the convergence of the algorithm and some experimental results are provided. >


Aims and Method: To evaluate cardiovascular risk in a rural inpatient psychiatric unit over a one-year period. Care records were analysed for risk factor recording, and cardiovascular risks estimated using the QRISK3 calculator, which estimates 10-year risk of myocardial infarction or stroke. Results: Of eligible patients, risk factor recording as part of routine care was completed in 86% of possible QRISK3 inputs, enabling QIRSK3 estimation in all eligible patients. QRISK3 for this group was raised (Relative risk: 3.8, 95%CI: 2.5 - 5.0). High risk of cardiovascular disease (QRISK3 score >10%) was detected in 28% of patients. Clinical Implications: This service evaluation demonstrated significant unmet need for cardiovascular risk reduction that could be identified as part of routine care. An opportunity exists to integrate mental and physical healthcare by routinely assessing cardiovascular risk in psychiatric inpatients. Resources and training are needed to produce this risk information and act on it.


Refining and extending the methodology introduced by Daines (2001), I present evidence that firms incorporated in Delaware were worth 2-3% more than non-Delaware firms during the period 1991-1996, but not significantly more after 1996. I present two potential explanations for this "disappearing" Delaware effect. First, doctrinal movements in the mid1990s might have solidified the Just Say No defense in Delaware, making Delaware's corporate law undifferentiated from the corporate law of other states. Second, "adaptive devices" (Kahan & Rock 2002), notably the increase in stock compensation during the 1990s, might have made takeover law no longer a binding constraint in many M&A transactions. I find some support in the empirical evidence for both of these explanations. * I thank George Baker, Lucian Bebchuk, Robert Daines, Marcel Kahan, Reinier Kraakman, Mark Ramseyer, Mark Roe, Leo Strine, and workshop participants at Georgetown Law School and Harvard Business School for helpful comments and discussions. The Disappearing Delaware Effect Guhan Subramanian Harvard Law School


We measure the nonlinearity and transparency of mixed GaS<inf>x</inf>Se<inf>1−x</inf> crystals and show that GaS<inf>0.4</inf>Se<inf>0.6</inf> is a promising nonlinear material for mid-IR (≫5 µm) OPO operation without twophoton absorption for a pump wavelength of 1064 nm.


The socket is the most important aspect of the artificial limb, constituting the critical interface between the amputee's stump and prosthesis. The design and fitting of the socket is also the most difficult procedure due to the uniqueness of each amputee's stump. An uncomfortable socket fit is the most common complaint from lower limb amputees with surveys revealing that amputees believe comfort are the most important aspects of the prosthesis and over half of all wearers are in moderate to severe pain for most of the time whilst wearing the prosthesis. Kristinsson argued that a transtibial socket can be designed to transfer loads primarily to limited areas of the limb such as the patella tendon and the medial flare, which in most cases found both ineffective and uncomfortable. There were inconsistencies in producing satisfactory PTB sockets because of inadequate training of prosthetist in the PTB technique. However, the TSB silicon liner socket has problems such as causing excessive perspiration, heating and odor etc. Therefore, a new socket is designed following the principle of alternative pressure and release to overcome the disadvantages and to check the socket with regard to stability, comfort and satisfaction.
Method: A single case study of a person 37-year-old, with transtibial amputation population took part in this study and was selected according to the inclusion criteria. The participant was provided patient information sheet and after taking the informed consent, the assessment and fabrication of the new socket were being proceeded, taking the cast on the first day. On the third day the newly designed socket along with prosthesis was provided with an adaptation period of 7 days. After 7 days the patient was called to check the stability with standing, comfort and satisfaction with a prosthetic socket comfort score.
Results and Discussion: The present socket is well suitable for transtibial patient in weight bearing position. It fits well to the contour of the adult patient. The socket was adjusted manually during rectification phase providing respective pressure in areas required.
Conclusion: The developed socket had a great effect on gait pattern of transtibial amputee. This socket provides adjustment for pressure, anterior, posterior, medial and lateral of the stump. It also creates surface for the placement of bony prominences. As it is a complex casting procedure, proper care should be taken to fabricate the casting of socket with minimal error. Further, innovative inventions will be required to refine more products and extensive study has to be carried out on the existing mode.

Key words: transtibial amputation, transtibial socket, tissue compression and release.


A design of the electron accelerator for excimer laser pumping is presented. The accelerator produces an electron beam of 250-keV electron energy, 20 × 140-cm beam cross-section with a beam current density up to 8.5 A/cm at 1+5.4 us pulse length. The methods for calculating an accelerator geometry are considered. Energy characteristics of laser radiation are presented, a radiation energy of 25 J being obtained for XeF∗ molecule at 281 active volume.


The deformable fluid actuators available on the market, i.e. pneumatic muscles and pneumatic springs, are designed to mainly exert compressive or tensile forces. This paper deals with a novel fluid deformable actuator, with three membranes, called BiFAc3, whose particular feature is the ability to exert both tensile and compressive forces. The structure of the actuator is based on three cylindrical coaxial nonisotropic membranes connected to two end plates, whose original shape allows the independent supply of the three internal chambers. The first part of the paper deals with the internal structure and the geometry of the actuator, describes the operating principle and presents a prototype. The second part presents a modelling methodology that can be used to design and analyse the actuator in dynamic applications. The mathematical model of the actuator is based on three different levels of complexity which correspond to three consecutive design stages. The model has been experimentally validated: it is a useful tool for the choice of the actuator's geometrical dimensions, in order to satisfy specific applicative requirements.


Farfield noise radiated from low‐tip‐speed propellers on the YO‐3A quiet observation aircraft and measured in flyover tests exhibited unexpected levels and trends that have been called the "quiet airplane paradox." Levels of rotational propeller noise were found to be higher than predicted by conventional axisymmetric theory, and as propeller tip speed was decreased below a given value, at constant thrust, both harmonic and broad‐band noise levels actually increased. Thus a "bucket" was formed in the SPL vs tip speed curve. In addition, the harmonic character of the flyover propeller noise was markedly different than that observed in static propeller tests. These data were declassified in 1973, and a program was conducted to investigate the paradoxical experimeutal results and to develop a theoretical explanation. The theoretical study considered propeller blade aerodynamics, nonuniform inflow through the propeller, chordwise blade loading, and, finally, propeller blade wake/wing interaction. It was concl...


The article discusses the process сrowdfunding's formation in modern Russia. The authors highlighted the reasons for the appearance of this phenomenon. They justified choice of Russian politicians of mechanism for collecting funds in political campaigns. The article characterizes trends in political fundraising and сrowdfunding in Russia. The study highlighted their advantages and disadvantages for application in political activity. The authors give examples of successful сrowdfunding campaigns in modern Russia.


OBJECTIVE
To study the effect of testosterone on spermatogenesis.

METHODS
Testosterone concentrations were measured in testicular interstitial fluid (IF), and serum sample from the testicular artery, testicular veins on the surface of the testis, and the peripheral venous, inferior vena cave and proximal spermatic veins in adult SD rats. The left and bilateral veins at the proximal end of the spermatic cord were ligated respectively. Testosterone concentrations and weight of the testis were measured, and the changes of the testicular morphology were studied 3 days and 21 days after ligation respectively.

RESULTS
The testosterone concentrations were highest in IF. The serum testosterone concentrations were highest in the testicular veins on the surface of the testis. The serum testosterone concentrations in the proximal spermatic veins, the testicular artery, the peripheral venous and inferior vena cave were (42.503 +/- 12.749), (42.503 +/- 12.749), (5.598 +/- 3.649), (2.533 +/- 1.719) and (2.418 +/- 1.495) mg/L respectively. Three days after the proximal spermatic veins were ligated bilaterally, the weights of the testis and the serum testosterone concentrations declined markedly. The epithelium of the seminiferous tubules degenerated slightly and part of the structure was indistinct. Three days after the left proximal spermatic veins were ligated, the weights of the left testis, the testosterone concentrations in the left IF and in the serum of the left testicular artery declined distinctly except the serum testosterone concentration of the peripheral venous, inferior vena cave and those of the right testis. The epithelium of the seminiferous tubules in the left testis degenerated slightly and part of the structure was indistinct. It was restored 21 days after ligation.

CONCLUSIONS
A "small circulation" (testis-the testicular veins-the spermatic veins-the spermatic artery-the testicular artery-testis) may exist. The results indicate that after ligation of the proximal spermatic veins, the reduction of the testosterone concentrations and changes of testicular morphology is temporary and may be recovered.


In this work, we investigate the relationships between social network structure and personality; we assess the performances of different subsets of structural network features, and in particular those concerned with ego-networks, in predicting the Big-5 personality traits. In addition to traditional survey-based data, this work focuses on social networks derived from real-life data gathered through smartphones. Besides showing that the latter are superior to the former for the task at hand, our results provide a fine-grained analysis of the contribution the various feature sets are able to provide to personality classification, along with an assessment of the relative merits of the various networks exploited.


This thesis examines the relationship which exists between the content of courses of study which lead to professional qualifications in Further Education Teaching and Youth Work and the relevance of that study to professional practices. Because of the changing nature of the work of Further Education colleges and Youth Work, brought about by the economic and social changes taking place in Britain in the 1970s, consideration is given to the possibility that elements of study or practice for one profession can be of use to practitioners of the other. An examination is also made of respondents' reactions to a variety of techniques regularly used by educationists and contrasts these replies with data about preferred forms of working. Two forms of questionnaire are used to collect data from Further Education Teachers, Youth Workers and Further Education Students while additional oral evidence obtained from a variety of respondents supplements the analysis of this data. The research findings are compared with published material about both professions and the techniques they use. Some recommendations for curriculum change are made.


The aim of this research is to study the job satisfaction and job performance in Guilan public sector. The method is correlative and population size is according to budgeting and planning statistic annals of 2009 include 6863 individuals. Sample size is 323 and selected by available non-probable samples. Data were collected by questionnaire and Cronbach's alpha coefficient was used. Results show that there is a meaningful relationship between job satisfaction In-role performance and innovative job performance and findings are in accordance with previous researches.


Objective To study the protective effect of nifedipine controlled release tablet on renal function from damage due to extracorporeal shock wave lithotripsy(ESWL).Methods 93 cases of renal stone underwent extracoporeal shock wave lithotripsy(ESWL) were randomly divided into 2 groups,the adalat gits group (n=56)and the control group(n=37).In the former group ,adalat gits was given 30mg once a day for 3 days before ESWL and 1 days after ESWL, but in the control group did not take any drug.Urinary albumin, immunoglobulin-G, β 2-microglobulin and Thmm-Horsfall protein were assayed to evaluate the renal function.Results In the control group,ALB, lgG and β 2-MG showed a significant increased(P0 01)and urinary THP was obviously reduced(P0 01),after ESWL. In the adalat gits group , ALB, lgG and β 2-MG also increased and urinary THP decreased after ESWL but statistically insignificant(P0 05).Conclusions Adalat gits could protect the renal function from damage due to ESWL.


In a previous project report, we proposed a waveform inversion (WI) algorithm for attenuation analysis in heterogeneous VTI (transversely isotropic with a vertical symmetry axis) media. Here, we supplement that method with the local similarity technique designed to remove the time shifts between the simulated and observed data. In the presence of velocity errors, this technique substantially stabilizes computation of the WI gradients and improves parameter estimation. The gradients are derived with the adjoint-state method, and four parameters describing the attenuation of Pand SVwaves are updated simultaneously. The algorithm is applied to multicomponent reflection data generated for a modified section of the BP TI model. The inversion significantly reduces the data misfit and recovers the long-wavelength components of the attenuation parameters, especially in the upper part of the section. Synthetic testing also shows that the inversion algorithm remains stable when the data are contaminated by mild Gaussian noise.


ABSTRACT Background This study investigated the ability of patients, naïve to adalimumab treatment and self-injection with an autoinjector (AI), to successfully self-administer AVT02, an adalimumab biosimilar, using a custom, ergonomic AI (Alvotech hf., Reykjavik, Iceland). Research design and methods This was a single-arm, open-label study, consisting of an 8-week active period and 48-week extension phase. Patients with moderate to severe rheumatoid arthritis (RA) self-administered 40 mg AVT02 subcutaneously via AI in the active period, followed by prefilled syringe in the extension phase. The primary endpoint was the percentage of successful self-injections up to Week 8. Usability and robustness of the AI were evaluated in the active period; safety, efficacy, pharmacokinetic and immunogenicity data were assessed throughout the study. Results The AI success rate was 100%. No handling events were noted up to Week 8. Both Ctrough measurements and immunogenicity profile were in line with expectations from previous studies, with no unexpected safety signals. Conclusions This study demonstrated that AVT02-AI can be successfully and reliably used for repeated self-injections of AVT02 by moderate to severe RA patients, despite no previous experience of adalimumab self-administration. The extension phase provides long-term efficacy and safety data for AVT02 in RA. Study identifier NCT04224194


It pointed that building talent strategy according to enterprise and improving and completing in practice had been basic managing thinking and strategy of enterprise formation,development and grandness.The correct knowledge of talent strategy was discussed and various system and condition to retain talent were detailed introduced so as to complete construction enterprise human resources culturing and enhance enterprise competence.


Rammeacris kiangsu Tsai is an important forest pest in China,and causes serious harm to bamboo production.To provide basic data for investigation and forecasting of occurrence,the development period,body size and characteristics of external genitalia of nymphs in different instars,and the pre-oviposition period of adults in R.kiangsu collected from Yongchang,Changnin,Taojiang,and Guilin were investigated.The results show that the developmental period of female and male nymphs were 68.3~73.6 days and 60.8~64.2 days respectively at 25 ℃.There were no significant differences both in female and male nymphs among the four populations.All male nymphs had five instars,but some of the female nymphs had five instars and some had six instars.The percent of nymphs that had six instars was 55.6 %,40.0 %,27.3 % and 17.0 % in Yongchang,Changning,Taojiang,and Guilin population,respectively.The developmental period of nymphs within 1~4th instars were 10~13 days respectively,the period of the 5th instars was about 17 days,and that of the 6th instars was more than 17 days.The pre-ovipositional periods of adult females in Yongchang,Changning,and Taojiang populations were about 35 days,but that of adults in the Guilin population was longer than 50 days.Meanwhile,the observation of nymphal external genitalia in different instars showed that the instars and sex of nymphs could be distinguished by the characteristics of the genitalia.Combined with the data collected from head width and femur length of hind leg of nymphs in different instars,the findings could provide reference for investigation and forecasting of occurrence.


The epidemiology and clinical manifestations of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection are different in children and adolescents compared with adults. Although coronavirus disease 2019 (COVID‐19) appears to be less common in children, with milder disease overall, severe complications may occur, including paediatric inflammatory multisystem syndrome (PIMS‐TS). Recognising the distinct needs of this population, the National COVID‐19 Clinical Evidence Taskforce formed a Paediatric and Adolescent Care Panel to provide living guidelines for Australian clinicians to manage children and adolescents with COVID‐19 and COVID‐19 complications. Living guidelines mean that these evidence‐based recommendations are updated in near real time to give reliable, contemporaneous advice to Australian clinicians providing paediatric care.


In order to obtain good inking performance and to achieve high quality printing,the performance indications related to the high speed affset print were comprehensively studied.The temperature induced by the high speed was considered.Starting with the roller arrangement of the inking system,the mechanism of heat generation was analysed and the method of temperature control was discussed in detail.


Background: An additional rib that develops from the seventh cervical vertebra is known as a cervical rib, a congenital anomaly placed above the typical first rib, affecting 0.2- 0.5 percent of the total population. It may be seen on either the left or right sides. The majority of patients have little or no complaints and are identified by chance during an X-ray or CT scan. Due to the extreme compression on the arteries, veins and nerves caused by the position of the rib, which varies in shape and size, they might develop thoracic outlet syndrome. A cervical rib is a prolonged ossification of the lateral costal segment of the Cervical 7th vertebra.
Clinical Presentation: A 18 years old female patient was diagnosed with cervical rib on X-ray due to persistent pain at right hand. Patient concern with reduced mobility of the right upper limb and unable to lift the hand. The patient went physiotherapy treatment which comprise of exercise and electro therapy for 10 weeks which resulted in improvements in pain and range of motion and functional activities
Conclusion: The case report suggest that a prompt structured physical rehab let to improving the functional goals progressively and significantly which is a measured aspect leading to a successful recovery.


In recent years, experiments on animals have established clearly that the intercostal muscle spindles and their reflexes play an important role in the control of breathing (Sears, 1964, 1965; von Euler 1965, 1966). In particular, the loop intercostal fusimotor (gamma) neurones-muscle spindle primary endings, intercostal alpha motoneurones-is believed to function as a servomechanism that automatically stabilizes the demanded length changes of the intercostal muscles (the demand for a certain tidal volume) against the mechanical load. The servo theory derives originally from work on limb muscles by Merton (1951) and Eldred and associates (1953), and an account of it is given by Matthews (1964) in his comprehensive review on muscle spindles. Previously, we sought evidence of a servo control of human respiratory muscles by studying electromyographically the effects on intercostal muscles of sudden alterations in mechanical load during spontaneous breathing (Newsom Davis e ta / . , 1966). In the present work, we have studied the effects of sudden changes in mechanical load while respiratory muscles are under voluntary activationincluding those, of special interest to this conference, which occur during phonation. Methods


At present, the worldwide health authority, in the form of the World Health Organisation (WHO) has drawn great attention to the importance of improving women's sexual health globally. This study was conducted to describe how women and health care professionals perceive sexual health and services that are currently provided in Saudi Arabia. The researcher adopted an exploratory, qualitative method to conduct the study with an ethnographic design. It was undertaken in two governmental hospitals in Jeddah city. Health care professionals tended to avoid initiating discussions about sexual matters in their clinical practices, to respect the cultural norms and avoid offending the patient. Many other barriers to talking about sexual topics in the clinic were also reported by the health care professionals in the current study. Using the Theory of Reasoned action as a theoretical framework to discuss the findings of the study this chapter sets out how the social norm pressures that are embedded in Saudi culture.


Let \(2<n<\omega\). Then \({\sf CA}_n\) denotes the class of cylindric algebras of dimension \(n\), \({\sf RCA}_n\) denotes the class of representable \(\sf CA_n\)s, \({\sf CRCA}_n\) denotes the class of completely representable \({\sf CA}_n\)s, and \({\sf Nr}_n{\sf CA}_{\omega}(\subseteq {\sf CA}_n\)) denotes the class of \(n\)-neat reducts of \({\sf CA}_{\omega}\)s. The elementary closure of the class \({\sf CRCA}_n\)s (\(\mathbf{K_n}\)) and the non-elementary class \({\sf At}({\sf Nr}_n{\sf CA}_{\omega})\) are characterized using two-player zero-sum games, where \({\sf At}\) is the operator of forming atom structures. It is shown that \(\mathbf{K_n}\) is not finitely axiomatizable and that it coincides with the class of atomic algebras in the elementary closure of \(\mathbf{S_c}{\sf Nr}_n{\sf CA}_{\omega}\) where \(\mathbf{S_c}\) is the operation of forming complete subalgebras. For any class \(\mathbf{L}\) such that \({\sf At}{\sf Nr}_n{\sf CA}_{\omega}\subseteq \mathbf{L}\subseteq {\sf At}\mathbf{K_n}\), it is proved that \({\bf SP}\mathfrak{Cm}\mathbf{L}={\sf RCA}_n\), where \({\sf Cm}\) is the dual operator to \(\sf At\); that of forming complex algebras. It is also shown that any class \(\mathbf{K}\) between \({\sf CRCA}_n\cap \mathbf{S_d}{\sf Nr}_n{\sf CA}_{\omega}\) and \(\mathbf{S_c}{\sf Nr}_n{\sf CA}_{n+3}\) is not first order definable, where \(\mathbf{S_d}\) is the operation of forming dense subalgebras, and that for any \(2<n<m\), any \(l\geq n+3\) any any class \(\mathbf{K}\) (such that \({\sf At}({\sf Nr}_n{\sf CA}_{m})\cap {\sf CRCA}_n\subseteq \mathbf{K}\subseteq {\sf At}\mathbf{S_c}{\sf Nr}_n{\sf CA}_{l}\), \(\mathbf{K}\) is not not first order definable either.


Purpose – The purpose of the paper is to demonstrate that organizational task interdependence has an impact on the performance of home teams in sport.Design/methodology/approach – The paper uses a cross‐sectional research design. It tests the authors' hypothesis using a probit analysis of nine years of data from Major League Baseball and eight years of data from the National Hockey League.Findings – The paper determines that the underlying task interdependence of a sport has a significant impact on the performance of a sport team.Originality/value – The paper argues that sport managers need to consider organizational structure when accounting for team performance. Moreover, the structure of the sport(s) needs to be considered when making adjustments to the league(s) that might affect the competitive balance.


An experimental study of thermocapillary convection of silicone oil (the Prandtl number Pr ≈ 18) was conducted in a shallow annular cavity with outer radius Ro = 55 mm and inner radius Ri = 15 or 27.5 mm for liquid heights H in the range 1–3 mm. The liquid layer is heated from the outer cylindrical wall and cooled at the inner wall. The experiments were performed over a wide range of Marangoni numbers, 400 < Ma < 10000. The measurement of surface temperatures and observation of instability structures were made by using an IR thermography technique. As Ma exceeded a critical value, hydrothermal waves were observed for thin liquid layers, H ⩽ 2.5 mm, of both the inner radii. These waves are characterized by curved spoke patterns propagating in the azimuthal direction. For thicker layers, H > 2.5 mm, multicell patterns were dominant. At low Ma, the multicell patterns were steady, toroidal rolls. As Ma was increased, the rolls began to rotate around the centre of the cavity and unsteady longitudinal rolls appeared. In the range 2.5 ⩽ H ⩽ 2.8 mm, hydrothermal waves and multicell coexisted. The transition map is presented in terms of Ma and Bod (the dynamic Bond number).


The saturation remanence normalization method of paleointensity estimation has been applied to more than 50 lunar samples, and has been calibrated in terms of standard intensity determinations done on 14 samples. These results suggest that a lunar surface field, comparable in intensity to the earth's magnetic field, existed from about 3.6 to 3.8 AE. Absolute paleointensity estimates and lunar surface field strength determinations are consistent with this observation. The data presented here differ from previous descriptions of the variation in the lunar field with time in that (A) the oldest samples (>3.9 AE) are among the most weakly magnetized; and (B) an order of magnitude drop in paleointensity is suggested between the time of extrusion of the Apollo 11 low and high potassium basalts. The limited range in age of the strongly magnetized lunar samples and the absence of shocked samples in this set argues against a solar source for the lunar paleofield or for fields arising from transient phenomena such as impacts. The coincidence of this high field era with the termination of basin forming impacts and the beginning of mare basalt extrusion suggests a common cause. A close approach of the moon to the earth at about 3.8 AE might account for all three phenomena. The confined duration of the strong lunar field may allow for the assignment of relative ages for certain lunar samples and surface features.


Laparoscopic suturing is a challenging skill to acquire, requiring extensive training. This study aims firstly to develop a novel self-directed mixed reality laparoscopic suturing training module using the Microsoft Hololens 2 headset and secondly to assess the feasibility of this training tool and advantages over conventional training methods.

 SuturePal is a self-directed mixed reality training module which combines didactic videos, text, and bespoke interactive 3D models. Ten medical students and surgical trainees participated in a single-blinded prospective randomised feasibility study. Participants received baseline teaching for laparoscopic intracorporeal knot tying and were subsequently randomised to either SuturePal (n=5) or conventional training (n=5). Baseline and post-training knots were recorded and assessed by two blinded examiners for time taken, precision, errors, and proficiency according to two previously validated objective assessment tools. Cognitive load was measured via the validated NASA-TLX tool and participant feedback was recorded.

 SuturePal users reported higher confidence levels (p=0.0476) and lower mental demand (p=0.0397) following training compared to those taught by conventional means. No statistical differences, however, were shown between groups when comparing objective measures of knot tying performance.

 SuturePal provides evidence for how mixed reality technology may enhance engagement in surgical skill acquisition by improving user experience and lowering mental demand. This contributes to the growing body of evidence that mixed reality may have a role in enhancing surgical training. However, further research in the form of larger scale studies is required to determine whether mixed reality improves objective performance of surgical trainees.


ABSTRACT We reported the synthesis of tris(pyridyl)phosphine selenide (TppSe) and tris(4-methylpyridin-2-yl)phosphine selenide (MeTppSe), which were prepared by a simple and straightforward one-pot method with red phosphorus in a KOH/DMSO suspension, and treatment of resulted phosphines with selenium in hot toluene. These compounds were characterized by mass spectroscopy, 1H, 13C and 31P NMR spectroscopies and the structure of MeTppSe was characterised by a single-crystal X-ray diffraction. Furthermore, The reactions of selenides with Fe(ClO4)2·6H2O afforded two new iron(II) mononuclear metal complexes [Fe(TppSe)2][ClO4]2·3DMF (1) and [Fe(MeTppSe)2][ClO4]2·2DMF (2). Detailed structural analyses and magnetic susceptibility measurements confirm no spin transition from low-spin to the high-spin state between 2 and 300 K in two iron(II) complexes. GRAPHICAL ABSTRACT


Compare outcomes of patients with olfactory neuroblastoma (ONB) without skull base involvement treated with and without resection of the dura and olfactory bulb.


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Fourteen people with HIV-1 on two decades of antiretroviral therapy had longitudinal measurements of intact, defective, and total proviral DNA. Three patterns of intact proviral DNA decay were revealed: 1) biphasic decline with markedly slower second phase decline; 2) initial decline that transitions to a zero-slope plateau; and 3) initial decline followed by later increases in intact proviral DNA. Defective proviral DNA levels were essentially stable. Mechanisms of slowing or reversal of second phase decay of intact proviral DNA may include the inability to clear cells with intact but transcriptionally silent proviruses and clonal expansion of cells with intact proviruses.


In this study, the effective low-complexity Convolutional Neural Network (CNN) inference network is implemented by the FPGA-based hardware accelerator for the biometric authentications. After the labeling processes, the eye images with partial iris and sclera zones are used to train and test the LeNet-based Lite-CNN model. Then the lightweight CNN classifier is rapidly prototyped via FPGA for hardware acceleration. Through testing, the proposed Lite-CNN model achieves up to 98% recognition accuracy with the eye images. Compared with the software-based implementation, the proposed Lite-CNN hardware accelerator provides similar detection accuracy, and the inference time of 0.0246 seconds is accelerated about 377 times on the Xilinx ZCU102 FPGA platform. Besides, compared with the previous FPGA implementation by the high level synthesis design, the proposed hardware acceleration design performs the computing speed more than about 92 times.


Using a reactive active species or reactive gas generated by the excited and / or unstable gas flow has been provided an apparatus and a process for modulating the surface energy of particles. The apparatus and process includes a process container, a part of this process the container is movable and has a form in which the particles are exposed to during the tumbling action thereof. The resulting surface treatment makes it possible to cause the modulation of the energy particles reduces the incidence of particle aggregation or agglomeration state is more easily dispersed in the liquid medium.


Background. Lymph node lymphocytes vary in their responsiveness to tumor. A technique has been developed that uses radiolabeled monoclonal antibody (MoAb) against the tumor‐associated mucin, TAG‐72, and a gamma‐detecting probe by which lymph nodes containing microscopic tumor and/or shed TAG‐72 can be identified in vivo. The immunologic characteristics of these lymph nodes were examined.