Institutions are known to have varying research strengths in different thematic areas. While some thematic areas are within the core competence of an institution, there may be other areas in which the institution is considered relatively week. This work proposes an expertise-based recommendation framework that can determine the stronger and weaker thematic areas of an institution based on their expertise and toss recommendations. The framework uses bibliometric and text data and applies methods from Network Science and Text Analytics. The recommendations provided can be useful for various purposes ranging from suggestions for institutional collaborations for improving an institution's research performance in a weaker thematic area (by pairing with an institution stronger in the corresponding thematic area) to research place recommendations to prospective researchers. This unique capability of the framework is demonstrated using 196 research institutions in India. Results are compared with available evidence from different international rankings and the ability of the framework to provide novel recommendations is established.


Studies based on fracture mechanics have been made on polyacetal toughened with a synthesized thermoplastic polyurethane. The effects of elongation rate and defects like holes and notches on tensile properties have been investigated. Using three-point bending specimens, fracture mechanics parameters such as strain energy release rate, G, Rice's contour integral, J, and fracture toughness, K have also been determined under plain stress conditions. The mechanical loss from the hysteresis curves, and ductile, brittle fractography using scanning electron microscopy have also been studied.


Video streaming exceeds all other traffic types on the internet. Now, it occupies a significant portion of total internet traffic. The transmission mechanism used by the video stream affects not only network traffic but also the users' Quality of Experience (QoE). Software Defined Networking (SDN) is a manageable, programmable, adaptable, and cost-effective emerging network architecture, which is very suitable for the dynamic natured high-bandwidth of modern applications. The OpenFlow protocol is a fundamental element in the creation of SDN solutions. Traffic engineering is a favorite mechanism used by network administrators when optimizing the existing networks and providing more services to customers is needed. This paper proposes a traffic rerouting approach in the video streaming flow management framework on SDN architecture, which can effectively reroute video streaming traffics to reduce packet loss and improve bit rates. It can calculate the current link utilization over the network links and it uses least-cost path rerouting rather than the default routing, reactive forwarding in the ONOS controller. The proposed method is validated by using the popular Mininet network emulation environment and OpenFlow features. The experimental results verify that the improvement of performance by the measurement of video streaming bit rates and packet loss of video traffic.


Recently, with the development of the COVID-19 pandemic and the next generation telecommunication network (5G), the metaverse, in which users interact with each other through avatars, has attracted increasingly attention. However, like traditional cyberspace, the metaverse, a three-dimensional (3D) virtual world built on the internet, also faces various unexpected security threats. In addition, some traditional forms and methods of cyberspace threats have undergone further evolution in the metaverse environment. Consequently, social engineering attacks become more applicable depending on the characteristics of the metaverse. In this paper, we explain that the user's avatar usage needs, psychological needs and immersion needs are the reasons for social engineering attacks in metaverse. Then, we present a conceptual model to describe how social engineering attacks work in metaverse. Finally, the effects of social engineering attacks in three metaverse application scenarios are presented. We hope that this research will draw the attention of designers and users of metaverse environments to effectively reduce the success rate of social engineering attacks in the metaverse.


Triboluminescence (TL) is the emission of light due to crystal fracture and has been known for centuries. One of the most common examples of TL is the flash created from chewing wintergreen Lifesavers. Since 2003, the authors have been measuring triboluminescent properties of phosphors, of which zinc sulfide doped with manganese (ZnS:Mn) is an example. Preliminary results indicate that impact velocities greater than 0.5 m/s produce measurable TL from ZnS:Mn. To extend this research, the investigation of the emission spectrum was chosen. This differs from using filtered photodetectors in that the spectral composition of fluorescence can be ascertained. Previous research has utilized a variety of schemes that include scratching, crushing, and grinding to generate TL. In our case, the material is activated by a short duration interaction of a dropped mass and a small number of luminescence centers. This research provides a basis for the characterization and selection of materials for future spacecraft impact detection schemes.


Having a Christmas tree (107, 207) and the wellhead (103) of the subsea well assembly. Tubing extending from the tubing hanger (113) into the well. Oil flow path portion from said tubing hanger (113) extending vertically to the vertical bore of the Christmas tree (111). Failure to produce self-closing main valve (PMV) (117) is arranged in the oil flow passage. The tubing hanger (113) is disposed below the Christmas tree (107), for example, is disposed in the wellhead (103). The Christmas tree (107) exhibiting a (111) separated from the vertical leg hole (115), said branch oil constitutes a part of the flow channel. The failure of production of self-closing main valve (PMV) (117) is arranged in the branch (115).


LBP is Architect; Master in Architecture and Urbanism at Universidade Federal do Pará, e-mail: email@example.com ACDC is Architect; MA in Urban Design (Universidade de Brasília, 1994); PhD in Architecture (Oxford Brookes University, 2002); Lecturer at Universidade Federal do Pará, e-mail: firstname.lastname@example.com Abstract The Brazilian Amazon has provoked preservationist discussions for decades, and although there has been a breakthrough in the recognition of the role of traditional populations for the biome maintenance, most strategies adopted in the country privileged the region's scale, without concern about local scale, particularly features of cities and of their inhabitants. The hypothesis that is pursued in this article is that the space of Western Amazonian frontier should offer innovative potential for urbanization solutions, especially in the treatment of open spaces. It also goes to prove that by not fully having structured its territory it could learn from human history, science framework, and from traditional knowledge. Assuming that urbanization process across this region takes place in a single space-time, this paper first approaches the dichotomy between city and nature built over time to deconstruct it, considering contemporary city's emerging spatiality and possible evolution scenarios. Marabá was adopted as case study, a city located between states and biomes, in the economic frontier circumstances of Western Amazonian. The research shows that from the existing open spaces raise an encouragement to reconcile urbanism and ecology.


Secondary metabolites like Tannins, Terpenoids, Alkaloids, Flavonoids play an important role in plant protection. Pharmaceuticals and pesticide industries are blessed with these economically important organic compounds (Patel and Jasrai, 2009; Wavare et al., 2017). There are many phytochemical available out of that nearly around ten thousand are plant secondary metabolites. These chemicals are having a defensive role and well established in the management of human diseases but their role in the management of plant diseases is still lacking (Satish et al., 2007 and Taiga et al., 2008). Phenols, Flavonoids, Quinones, Tannins, Alkaloids, Saponins, Sterols and International Journal of Current Microbiology and Applied Sciences ISSN: 2319-7706 Volume 9 Number 5 (2020) Journal homepage: http://www.ijcmas.com


【In the age of digital convergence, it is expected that quality of life of human beings can be improved by converged devices and services. Researches concerning change of buying patterns and consumer behaviors in these contexts have to be progressed actively. To investigate future trend of consumer behaviors, we used focus group interview for Qualitative approach in the first step and then conducted questionnaire survey for experts in order to get validity and feasibility of research results. As result of research we suggested eight propositions by FGI for 20s target consumers. Additionally, on the basis of qualitative research, by questionnaire survey for 22 experts two perspectives of positive and negative views In future trends were proposed. Results can give lots of Implications and research motivations to academia, practices and workers in public policies who have interests in change of consumer behaviors, thinking styles, and life style under digital convergent environment.】


An approach for early-stage ecodesign of an enzyme based process was developed by coupling process modeling, Life Cycle Assessment and flowsheet design, to evaluate the real advantages of the direct synthesis of low molar mass dextrans from sucrose.


Constraining depth–temperature conditions of syn‐orogenic burial metamorphism of syn‐orogenic sediments in a foreland basin provides an innovative way to investigate the thermomechanical state of the lithosphere. In central Australia, major intraplate deformation resulted in 10 km of syn‐orogenic sedimentation in a basin approximately 70 km wide. The deep level of burial in the foreland of the intraplate orogen requires the involvement of weak lithosphere with an elastic thickness of ≤20 km. The profound flexural response of the foreland region indicates that major intraplate deformation in central Australia was localised into a region of dramatically weakened lithosphere.


Experimental results on deep subwavelength resolution of defects are presented for the first time in the context of guided ultrasonic wave inspection of defects, using novel "structured channel" metamaterials. An Aluminum bar with side-drilled holes is used as a test sample, interrogated by the fundamental bar-guided symmetric mode. Simulations were conducted to optimize dimensional parameters of the metamaterial structure. Experiments using metamaterials fabricated accordingly demonstrate a resolution down to 1/72 of the operating wavelength, potentially bringing the resolution of guided wave inspection to the same range as that of bulk ultrasonics. This work has much promise for remote inspection in industry and biomedicine.


Abstract Aim: To quantify the variability between radiation oncologists (ROs) when outlining axillary nodes in breast cancer. Material and methods: For each participating center, three ROs with different levels of expertise, i.e., junior (J), senior (S) and expert (E), contoured axillary nodal levels (L1, L2, L3 and L4) on the CT images of three different patients (P) of an increasing degree of anatomical complexity (from P1 to P2 to P3), according to contouring guidelines. Consensus contours were generated using the simultaneous truth and performance level estimation (STAPLE) method. Results: Fifteen centers and 42 ROs participated. Overall, the median Dice similarity coefficient was 0.66. Statistically significant differences were observed according to the level of expertise (better agreement for J and E, worse for S); the axillary level (better agreement for L1 and L4, worse for L3); the patient (better agreement for P1, worse for P3). Statistically significant differences in contouring were found in 18% of the inter-center comparison. Less than a half of the centers could claim to have a good agreement between the internal ROs. Conclusions: The overall intra-institute and inter-institute agreement was moderate. Central lymph-node levels were the most critical and variability increased as the complexity of the patient's anatomy increased. These findings might have an effect on the interpretation of results from multicenter and even mono-institute studies.


Objective To prepare cross sections of frozen gross specimen to provide adequate original data for the three dimensional reestablishment. Methods Based on the frozen section method, the frozen soft tissue microtome was designed and prepared. Some relevant frozen techniques were improved. The calibration line was buried in the ice box with the use of calibration board so that the thickness of the section could be adjusted by the spiral ascending and descending system. Results The thickness of the section was thinner than 0.9 mm (0.865 mm in our experiment). The problem of calibration of the frozen specimen was solved. Conclusion The self made cryomicrootome is of simple operation, low cost and practical. By using this kind of cryomicrotome, clear images, accurate calibration in comparatively short experimental time can be obtained. This kind of cryomicrotome may have a wide application in the three dimensional re establishment of the biological tissues.


One of the peculiarity literary productions of Capuchins in the Seventeenth Century was El ente dilucidado, written by Priest Antonio de Fuentelapena. It is a composition that pursues a philosophical nature to unravel the nature of metaphysical entities (particularly the nature of the elves) and contains the final dissertation on the man's air capabilities. One of the aims of the author was to banish the fear for elves, as it was popularly believed; they were evil spirits, ghosts or souls harmful to man. The article discusses how Fuentelapena argued the nature of the elves and their role in the metaphysical world. We will finish with some considerations on the rereading that the text deserves in the light of the history.


This paper introduce ubiquitous technology, and how to apply ubiquitous computer in education, enhancing internet for the development of education services-the foreign language teaching platform is based on multi-media technology, mobile device technology and technical support online communities, building a new adaptive foreign language learning system, that is personalized learners based on the model, through its research-related data mining algorithms in the appli-cation of adaptive learning, students found by the personality, learning the rules of conduct, formation of adaptive learning strategies available to students, educators and parents.The purpose of this study is to build a new adaptive learning system, a personalized learning management system, which can be used in other aspects.


Based on the measured fracture production of the rock body in the field, the disc fracture hypothesis is used to generate three groups of fractures to form a fracture network by the Monte-Carlo method. The three-dimensional fracture network is simplified into a spatial one-dimensional pipe element model based on the hypothesis of water channel flow in the fractures, and the equivalent pipe diameter of the pipe element is considered to be linearly related to the fracture width. The equivalent permeability tensor is obtained by using a genetic algorithm to obtain the ratio of the equivalent pipe diameter to aperture size for each group of fissures, and compared with the equivalent permeability tensor obtained by the overall single-parameter model and direct algorithm. In comparison with the measured permeability tensor, it is concluded that the multiparameter model can better characterize the permeability tensor than the single-parameter model.


A 29-year-old man visited our hospital complaining of multiple xanthomas occurred bilaterally at the achilles tendon, the lateral dorsal aspect of the foot, the tibial tuberosity, the lateral aspect of the elbow, and the dorsal aspect of the 2nd and the 3rd right metacarpal joint.Tumors were found to be elastic hard with comparatively clear edge. There were neither spontaneous pain nor tenderness, without limitation of joints movement. Blood examinations revealed 372mg/dl of cholesterol level and 3.8mm of β-lipoprotein.He was diagnosed as hyperlipemia of II a type with xanthomas. Tumors were resected, and the histological study made sure of the diagnosis.His father was also found to have IIa type xanthomas.


Kibbutzim were egalitarian communities forced by their environment to endorse market orientation. Using a sample of 63% of the kibbutzim over an eight year-period we examined the effect of ideology, crisis intensity, demographic depletion, and type of manufacturing industry on change magnitude. All but the last predictor have been found to affect change intensity consistently.


Seasonal oscillations in the GPS position time series can arise from real geophysical effects and numerical artefacts. According to Dong et al. (2002) environmental loading effects can account for approximately 40% of the total variance of the annual signals in GPS time series, however using generally acknowledged methods (e.g. Least Squares Estimation, Wavelet Decomposition, Singular Spectrum Analysis) to model seasonal signals we are not able to separate real from spurious signals (effects of mismodelling aliased into annual period as well as draconitic). Therefore, we propose to use Multichannel Singular Spectrum Analysis (MSSA) to determine seasonal oscillations (with annual and semi-annual periods) from GPS position time series and environmental loading displacement models. The MSSA approach is an extension of the classical Karhunen-Loève method and it is a special case of SSA for multivariate time series. The main advantage of MSSA is the possibility to extract common seasonal signals for stations from selected area and to investigate the causality between a set of time series as well. In this research, we explored the ability of MSSA application to separate real geophysical effects from spurious effects in GPS time series. For this purpose, we used GPS position changes and environmental loading models. We analysed the topocentric time series from 250 selected stations located worldwide, delivered from Network Solution obtained by the International GNSS Service (IGS) as a contribution to the latest realization of the International Terrestrial Reference System (namely ITRF2014, Rebishung et al., 2016). We also researched atmospheric, hydrological and non-tidal oceanic loading models provided by the EOST/IPGS Loading Service in the Centre-of-Figure (CF) reference frame. The analysed displacements were estimated from ERA-Interim (surface pressure), MERRA-land (soil moisture and snow) as well as ECCÔ2 ocean bottom pressure. We used Multichannel Singular Spectrum Analysis to determine common seasonal signals in two case studies with adopted a 3-years lag-window as the optimal window size. We also inferred the statistical significance of oscillations through the Monte Carlo MSSA method (Allen and Robertson, 1996). In the first case study, we investigated the common spatio-temporal seasonal signals for all stations. For this purpose, we divided selected stations with respect to the continents. For instance, for stations located in Europe, seasonal oscillations accounts for approximately 45% of the GPS-derived data variance. Much higher variance of seasonal signals is explained by hydrological loadings of about 92%, while the non-tidal oceanic loading accounted for 31% of total variance. In the second case study, we analysed the capability of the MSSA method to establish a causality between several time series. Each of estimated Principal Component represents pattern of the common signal for all analysed data. For ZIMM station (Zimmerwald, Switzerland), the 1st, 2nd and 9th, 10th Principal Components, which accounts for 35% of the variance, corresponds to the annual and semi-annual signals. In this part, we applied the non-parametric MSSA approach to extract the common seasonal signals for GPS time series and environmental loadings for each of the 250 stations with clear statement, that some part of seasonal signal reflects the real geophysical effects.


In this article it is stated the convenience of combining the conventional ward round with an additional and independent group  activity with third year students  of the Medical major; this would facilitate the achievement of formative objectives with these abilities, at least during the first weeks of the subject clinical propedeutics and medical semiology. An analysis of some particularities    is made which differentiates the ward round in the subjects clinical propedeutics and internal medicine.; differences determined by the level of training sense-perceptive abilities with which students start in both subjects and determinant  at the same time of adequacies in professional performance.


Ch*u Y u an 's o r i g i n a l i t y and c r e a t i v i t y may a l s o be th e 129 r e s u l t o f h o m o se x u a lity . In "L i s a o ," C h 'u Yuan l i k e s to d e c o ra te h im s e lf w ith f r a g r a n t f lo w e rs (1 1 . 5 6 -3 7 , 5 8 , and 6 3 ) . T h is un u s u a l c l e a n l i n e s s and p u re n e s s h a s lo n g been ta k e n a s a sym bol o f C h'u Y u an 's i n c o r r u p t ib l e c h a r a c t e r . As f a r a s sham anism i s c o n c e rn e d , how ever, t h i s i s q u i t e a common phenomenon. A cco rd ing to R oland B . D ixon, th e c le a n l in e s s o f th e A m erican shaman "may be a t t a i n e d by f r e q u e n t b a th in g i n rem o te la k e s o r s t r e a m s , by th e u se o f th e s u d a to ry , o r by e i t h e r o f th e s e m eans, w ith th e added re q u ire m e n t o f ru b b in g th e body o r s c e n t in g i t w ith f r a g r a n t h e rb s and r o o t s . F u r th e rm o re , i n "L i s a o " C h 'u Yuan e a t s th e p e t a l s o f chrysanthem um ( 1 . 3 4 ) . T h is i s a n a lo g o u s to th e p r a c t i c e o f th e p r i e s t e s s o f A po llo i n a n c ie n t G re ec e , on w hich Ja n e E l le n H a r r is o n comments: The a n c ie n t A th e n ia n , l i k e th e .modem sa v a g e , be l i e v e d t h a t su c h p l a n t s ( a s buckhorn) have th e power Of k e e p in g o f f e v i l s p i r i t s , o r r a t h e r p e rh a p s o f e j e c t i n g them when a lr e a d y i n p o s s e s s io n : Chewing a s u b s ta n c e was n a tu r a l l y a th o ro u g h and e f f i c i e n t way o f a s s i m i l a t i n g i t s v i r t u e s . The p r i e s t e s s o f A p o llo chewed th e l a u r e l l e a f . I t seem s r a t h e r a s a means o f e j e c t i n g th e bad s p i r i t s th a n to o b ta in i n s p i r a t i o n from th e g o o d .° ° Sun T z 'u -c h o u h as a l r e a d y p o in te d c u t t h a t C h 'u Y u an 's p re  d i l e c t i o n f o r f lo w e rs i n d ic a t e s t h a t he was a hom osexual. 130 Y et we s h o u ld n o t d e s p is e h im , f o r i t i s n o t u n u su a l f o r a shaman to become a p e r v e r t . I n s t e a d , we s h o u ld a p p r e c ia te h i s d e v ia t io n from th e p s y c h o a n a ly t ic p o in t o f v iew .


Chapter 1 Introduction Chapter 2 Mexico and U.S. Worldwide Immigration Policy Chapter 3 Mexican Social and Economic Policy and Emigration Chapter 4 Do Mexican Agricultural Policies Stimulate Emigration? Chapter 5 Mexican Immigration and the U.S. Population Chapter 6 Fiscal Impacts of Mexican Migration to the United States Chapter 7 Labor Market Implications of Mexican Migration: Economies of Scale/ Innovation/ and Entrepreneurship Chapter 8 Policy, Politics, and Emigration: Reexamining the Mexican Experience Chapter 9 U.S. Public Perceptions and Reactions to Mexican Migration Chapter 10 NAFTA and Mexican Immigration Chapter 11 U.S. Foreign Policy and Mexican Immigration Chapter 12 Conclusion


Three teacher educators at two colleges in western New York have used content analysis to analyze prospective undergraduate and graduate students' applications to their early childhood education programs. Despite a number of apparent differences between both the applicants and the programs to which they were applying, there was a remarkable degree of similarity in applicant essays around the ways in which they constructed and communicated their understandings of the "good" early childhood teacher. These constructions raise questions about how this discourse is disseminated, understood, taken up, and perpetuated in teacher education programs. The implications of this analysis pose challenges and present possibilities for early childhood teacher educators working from nonmainstream perspectives.


ObjectiveTo investigate the therapeutic effect of puerarin combined with Lisinopril on patients with early diabetic nephropathy(EDN).Methods68 EDN patients were randomly divided into two groups,Lisinopril was given for oral use in control group and treatment group.In addition,puerarin intervenous drop infusion therapy was applied in the treatment group.Urinary albumin excretion rate was observed 4 weeks later.ResultsThe total effective rate of treatment group is obviously higher than that of the control group(P0.01).ConclusionThe combination of puerarin and Lisinopril has a significant therapeutic effect on patients with early diabetic nephropathy and it is worth popularizing.


This paper presents a set of maxims as governing the negotiation of identities in conversation. The paper argues that the linguistic code choices which participants make, interpreted according to the negotiation maxims, generate conversational implicatures regarding the rights and obligations between speaker and addressee for the current talk exchange. (Code choices may be between styles or dialects within a single language, or between languages.) The major aim of the paper is to present a model which explains variation in linguistic code choice. The model relies on the premise that participants in conversation interpret all code choices in terms of a natural theory of markedness. That is, as part of their communicative competence (Hymes 1972), speakers recognize choices as either unmarked or marked in reference to the norms of their speech community. Community norms designate specific linguistic choices as the unmarked realization of a specific set of rights and obligations holding between a speaker and addressee. It is this association between code choices and rights-and-obligations sets which enables us to calculate a conversational implicature from a code choice. To say that speaking is situated behavior is a favorite axiom of sociolinguists. This paper argues, rather, that speaking is interactional behavior. While code choices are always situated, they are not a function of situation, but rather of negotiation, so that speaking is seen as a rational process involving decisions. Operating within the frame of markedness, speakers negotiate rights and obligations interactionaUy by their code choices. The maxims which direct the negotiation follow from a negotiation principle. This principle and its maxims are patterned after the cooperative principle and its maxims which Grice (1975: 45) proposed as in effect during any conversation. The cooperative principle enjoins speakers to 'make your conversational contribution such as is required, at the stage at which it occurs, by the accepted purpose or direction of the talk exchange'. The maxims which follow from this principle have to do with quantity, quality, relation, and


The hardware configuration and software designing of FCS for saturated vapour flow were given in the article.High compensation accuracy was acquired and the flow-accumulator was saved up.


We present the Braga method which we use to get verified OCaml programs by extraction from fully specified Coq terms. Unlike structural recursion which is accepted as is by Coq, the Braga method works systematically with more involved recursive schemes, including the nonterminating schemes of partial algorithms, nested or mutually recursive schemes, etc. The method is based on two main concepts linked together: an inductive description of the computational graph of an algorithm and an inductive characterization of its domain. The computational graph mimics the structure of recursive calls of the algorithm and serves both (a) as a guideline for the definition of a domain predicate of which the inductive structure is compatible with recursive calls; and (b) as a conformity predicate to ensure that the Coq algorithm logically reflects the original algorithm at a low-level. We illustrate the Braga method on various concrete recursive algorithms, including unbounded search, "fold-left" from the tail, non-terminating depth-first search, Paulson's normalization algorithm and first-order unification, the last two algorithms being examples of nested recursive schemes. The method allows us to easily show partial correctness and characterize termination in each case, and in addition, the intended OCaml algorithm is faithfully extracted from Coq code. All the results are implemented in Coq and freely accessible on GitHub.


In this paper, distributed detection of process failures is studied. Erroneous evolutions, corresponding to failure situations, are described by chronicles. Every chronicle is composed of a set of events, and of a set of time constraints between these events. A chronicle can be decomposed into sub-chronicles distributed into several monitoring sites (systems). The objective of a monitoring site is to recognize a sub-chronicle. A specific reasoning considering relative time between event occurrences is proposed to provide time consistency of the mechanisms set Combining t-time Petri nets and p-time Petri nets, p-t-time Petri nets are used to represent these chronicles. When the Petri net reaches a particular state, a sub-chronicle is recognized. A symptom is detected when all the sub-chronicles associated to the initial chronicle have been recognized.


This article analyses the background of the new reform personnel system of universities. It also points out the present main problems existing in the reform of personnel system of universities . And constructional countermeasures are advanced.


Dryopteris crassirhizoma (DC) has a wide range of pharmacological effects, including antibacterial, anti-influenza virus, anti-tumor, anti-reverse transcriptase and antioxidant effects. However, the inhibitory effect of DC on allergic inflammatory response remains unclear; therefore, the current study used an experimental ovalbumin (OVA)-induced allergic asthma mouse model and phorbol myristate acetate (PMA)- and A23187-stimulated HMC-1 cells to reveal the effects of DC in regulating airway inflammation and its possible mechanism. Allergic asthma was initiated in BALB/c mice via exposure to OVA emulsified in aluminum, on days 1 and 14. Thereafter, the mice were treated with DC or dexamethasone (Dex) orally, before being challenged, from days 15 to 26. Subsequently, the mice were challenged with OVA on days 27, 28 and 29. The results of histological analysis indicated that the administration of DC decreased the number of inflammatory cells in the bronchoalveolar lavage fluid (BALF) and suppressed eosinophilic infiltration, mucus production and collagen deposition in the lung tissue. DC treatment increased the level of T helper type 1 (Th1) cytokines (IL-10 and interferon (IFN)-γ) and decreased the levels Th2 cytokines (IL-4, IL-5 and IL-13) and proinflammatory cytokines (IL-6 and TNF-α). Furthermore, DC treatment inhibited the activation of NF-κB signaling (NF-κB, p-NF-κB, IκB and p-IκB), both in BALF and lung homogenates. Serum levels of total IgE and OVA-specific IgE and IgG1 were significantly lower after DC treatment compared with after OVA treatment. However, the anti-inflammatory effect of OVA-specific IgG2a was higher after DC treatment. In addition, DC treatment attenuated the production of proinflammatory cytokines, including IL-6 and TNF-α, and the activation of NF-κB signaling (NF-κB and p-NF-κB), in PMA and calcium ionophore A23187-stimulated HMC-1 cells. In summary, the current study demonstrated that DC acts a potent anti-allergic and anti-inflammatory drug by modulating the Th1 and Th2 response and reducing the allergic inflammatory reaction in PMA and A23187-stimulated HMC-1 cells via NF-κB signaling in an OVA-induced allergic asthma model.


We are using automatic photoelectric telescopes at the Tennessee State University Center for Automated Space Science to search for planets around nearby stars in our galaxy. Over the past several years, wc have developed the capability to make extremely precise measurements of brightness changes in Sun-like stars with automatic telescopes. Extensive quality control and calibration measurements result in a precision of 0.l% for a single nightly observation and 0.0270 for yearly means, far better than previously thought possible with ground-based observations. We are able, for the first time, to trace brightness changes in Sun-like stars that are of similar amplitude to brightness changes in the Sun, whose changes can be observed only with space-based radiometers. Recently exciting discoveries of the first extrasolar planets have been announced, based on the detection of very small radial-velocity variations that imply the existence of planets in orbit around several Sun-like stars. Our precise brightness measurements have been crucial for the confirmation of these discoveries by helping to eliminate alternative explanations for the radial-velocity variations. With our automatic telescopes, we are also searching for transits of these planets across the disks of their stars in order to conclusively verify their existence. The detection of transits would provide the first direct measurements of the sizes, masses, and densities of these planets and, hence, information on their compositions and origins.


This letter reveals that unusual elasticity of nanocrystalline diamond is consistently explained by stacking fault inside the diamond grains instead of the graphitic plate inclusion, which was only possible mechanism. Ab initio calculation shows that stacking fault introduced in the diamond structure behaves as graphitic sp2 bonds, and the elastic constants calculated from the strain-energy relationship agree with the acoustic measurements.


This work tries to analyze whether economic information in newspapers is perceived as a credible source for individuals to make their investment decisions considering two main aspects: they have little knowledge in this matter and they do not have many resources to invest much money in financial products. In this way, we have focused our investigation on economic behaviours of "non experts" individuals and the reasons of their decisions which are, at last, based on journalistic financial information.


Hashimoto's encephalopathy is non-vasculitic autoimmune steroid responsive encephalopathy. It is an uncommon syndrome characterized by altered level of consciousness, confusion, seizures and myoclonus. Exact pathogenesis is yet to be determined though humoral hyper-immune response is favored mechanism rather than dysthyroidism. We present a case of Hashimoto's encephalopathy in an eighty years old lady who presented with unexplained drowsiness. Extensive workup for the cause of drowsiness was carried outto find structural, metabolic, autoimmune or para-neoplastic etiology only to reveal high titers of anti-TPO antibodies. Patient responded remarkably to high dose steroids.


In the working world the need for training and development tbsp due to get the manpower that has tbsp good need for training before power kerj it is done or before an employee, with the training provided the company or agency to its employees in order to increase the productivity of their employees in the field tbsp. Productivity is the ability to motivate yourself and develop their work in maxsimal, because in every public and private Integration no performance assessment. All of these variables are very berhungan between one another, because of the training and development of tablespoons is highly variable simultaneously as well as other variables.


Detachment folds are very common structures in fold-and-thrust belts but currently are poorly understood and hence are not reconstructed using an established, consistent method. This report presents observations of the characteristics of the Straight Creek detachment anticline (SCDA), as an early phase in a general study about the geometry and kinematics of detachment folds. Ultimately, this study aims to establish quantitative geometric and kinematic models that can be used to better recognize and consistently reconstruct the geometry of detachment folds in fold-and-thrust belts. The Straight Creek detachment anticline (SCDA) is the first fold to be analyzed in the general shtdy. Observations from the SCDA will be incorporated with observations from other detachment folds in order to guide the construction of the new more actualistic geometric and kinematic models. The SCDA is an open inclined fold at the headwaters of Straight Creek in Alaska's northeastern Brooks Range. The fold is defined by competent carbonate rocks of the Cartmniferous Lisburne Limestone. The shortening required to form the fold occurred above a detaclment in the Mississippian Kayak Shale and is accommodated in the Kayak Shale by internal deformation. The Kayak Shale is 1.5 times thicker in the anticlinal core than it is beneath the limbs of the SCDA. The detachment is underlain by, in descending order, the Mississippian Kekiktuk Conglomerate, a regional angular unconformity, and poly-deformed pre-Mississippian rocks. Regionally, the SCDA is above the roof thrust of a forward (north)-propagating, hindwarddipping passive-roof duplex with horses defining fault-bend folds (Wallace, 1992). The SCDA lies above the northdipping forelimb of one of these fault-bend folds and it records a southdirected or backthrust sense of displacement relative to the underlying forelimb. The geometry of the SCDA and distribution of outcrop-scale structures within the fold suggest a complex kinematic evolution. Geologic indicators of irreversible strain are present in two of the three hinges of the SCDA, area-loss in the core of the fold is suggested by a well-c~eveloped solution cleavage in the Kayak Shale, and no apparent structural overprinting indicative of hinge migration is observed on the limbs of the fold. These and other observations, including quantitative strain data, will be used to develop a realistic geometric and kinematic model for the SCDA to be modified from a model by Homza and Wallace (in review). This model will be a modification of the current model of Homza and Wallace (in review). In the last stage of the larger study, data from several other detachment folds will be incorporated into a general best-fit model for detachment folds.


In order to get the characteristics of time domain and frequency domain of fields radiated from corona discharge,the back noise outside of laboratory is researched firstly,and then the characteristics of signal radiated from corona discharge are experimentally researched.The effect of different factors,such as different polarity of potential,direction of polarization of antenna,receiving distance,the shape of discharging needle,temperature and humidity,on the waveform and spectrum of signal radiated from corona discharge.The experimental results show that the waveform of signal radiated from corona discharge has a steep rising edge;the spectrum of signal radiated from corona discharge is continual,of which frequency range is from 20 to 100MHz;when the polarity is different,the waveform of signal radiated from corona discharge is different,and the amplitude of signal of positive corona is higher than of negative corona;the politicization mode of fields radiated from corona discharge is vertical;the intensity of fields radiated from corona discharge is inversely proportional to the receiving distance;the higher the relative humidity is,the higher the amplitude is.The above results are very important to the research and control of corona discharge that happens on the high-voltage electrical apparatus or EHV transmission line,etc.


As Osama bin Laden killed in a raid in 2011, the world seems to be in peace. But far away in
Southeast Asia terrorism still got its roots. Indonesia as the largest country in the region, and the biggest
Muslim population country in the world has its time to face. More Muslim group, various affiliations,
many direct interactions to other countries brings more possible threat to security. And the closest friend
to Muslim groups also lies in the region, Malay, Moro of Philippines, Pattani of Thailand and Rohingya in
Myanmar. The year of 2012 shows some terrorist action in Indonesia. Shooting, attacks, bombings,
happen in some areas in Indonesia. The casualties could be minor, but it spread fear to tourists, MNC's
employees, Embassies staffs, and even the local citizens. For the majority Muslim people in Indonesia,
terror is an evil act and it will be condemned. Two biggest Islamic organizations in Indonesia NU and
Muhammadiyah urge all Islamic schools to coordinate more to fight terrorism, and it's also needed to
coordinate with government and the police. Terrorist cells have to be identified clearly before it is
captured and arrested, but should be careful to make difference with the small groups which only
teaching Qur'an, Hadith and Arabic language. As the globalization spread and less border inspection, all
the groups tends to have better relations with the similar groups in other countries, but it is important to
know it's not just about terror, it could be economic interaction, supporting human right and spreading
peace and tolerance to other Muslim communities in the world. Fighting terrorism is about to
understand Muslim Communities, to understand Islamic teaching, to coordinate among governments,
Security Officer and Muslim Leader, and to coordinate to another countries.


A new species of Eugenia is here described and illustrated. Eugenia submontana is known from submontane Atlantic Forest in Pernambuco and is related to species bearing inflorescences with short internodes. E. submontana differs from related species in having sulcate midvein on adaxial leaf surface, short bracteoles and calyx lobes, a squared staminal ring and globose fruits with smooth surface. We also present here the first description of the fruits of Eugenia culicina , as well as a revision of its conservation status in light of new information.


This study aims to find out the application of the role-playing method for speaking skills in children aged 5-6 years at PAUD BKB HI Kutilang, Petir District, Serang Regency, Banten. The type of research used in this research is Classroom Action Research (CAR). The subjects in the study were children aged 5-6 years at PAUD Kutilang, totaling 12 children. Data collection was taken from observation sheets, interviews, and documentation. This research method has been implemented in two cycles of activities. Based on the results of the research and discussion that has been carried out, it is concluded that the role playing method can improve the speaking ability of children aged 5-6 years in PAUD BKB HI Kutilang, experiencing a very significant increase from the beginning of the pre-cycle with low results and in the second cycle which experienced the increase from the first cycle which increased very significantly. The increase in speaking ability can be seen from the percentage of data obtained in pre-action, Cycle I and Cycle II. At the pre-action stage, most of the children were included in the criteria for not yet developed, which was 43.75%, in the first cycle the children's speaking ability increased in the criteria for starting to develop with the total percentage score of the first cycle of 56.95%. In the second cycle of action increased to 70.83%. Learning is said to be successful because children's writing skills have increased by more than 70% from the initial conditions before the action and are in accordance with predetermined success indicators.


The invention provides a thermal treatment method for improving the low-temperature impact toughness of rods and belongs to the technical field of thermal treatment machining. The thermal treatment method includes a quenching process, wherein the hot-rolling large rods or thermal treatment workpieces are put in a thermal treatment furnace at the temperature of 840 DEG C to 860 DEG C to be heated, and the temperature is kept for 60 min to 120 min; and then a water-cooling or oil quenching manner is adopted; and a tempering process, wherein the rods or workpieces obtained after moderate quenching treatment is conducted are put into a tempering furnace at the temperature of 610 DEG C to 640 DEG C, the temperature is kept for 60 min to 120 min, and the rods or workpieces are water-cooled to the room temperature after being taken out of the furnace. By the adoption of the thermal treatment method, to overcome the defect that oil quenching capacity is insufficient, the quenching degree of large bolts is increased effectively, the tensile strength ranges from 861 MPa to 944 MPa, the yield strength ranges from 727 MPa to 804 MPa, the percentage elongation after fracture reaches 19.5% to 21.8%, the percentage reduction of the area Z ranges from 59% to 64%, and -100 DEG C impact absorbing energy Akv ranges from 27 J to 50.1 J. The tensile strength of workblank workpieces is 943 MPa, the yield strength is 818 MPa, the percentage elongation after fracture reaches 18.3%, the percentage reduction of the area Z is 63%, and the -100 DEG C impact absorbing energy Akv is 33 J.


This study examines the relationship between corporate governance and corporate performance. This study employs a multiple regression to test the hypothesis that corporate governance and corporate performance are positively related. The rating of corporate governance perception index (CGPI) for 2001 and 2002 by the Indonesian Institute for Corporate Governance is used to measure the corporate governance implementation, and Tobin's q as a market performance measurement (Klapper dan Love, 2002; Black, dkk. 2003) and return on equity (ROE) as operasional performance measurement (Klapper dan Love, 2002). The analysis shows that there is a no significant relationship between corporate governance index and Tobin's q but there is a significant positive relationship between corporate governance index and return on equity. It means that corporate governance implementation affect the operational performance, but market does not respond the implementation of corporate governance immediately.


This paper pretends to show of the work experience of a profesional s team in a Primary Health Care and Community Action Center in Buenos Aires city, which includes as geographical area a shanty town and a transitory dwelling nucleus. The objetives are: to reflect, according to the experience of intervention, the ways of approach and the changes that have taken place in the relation of poverty-feeding-malnourished in the last decade; and to point out possible lines of investigation.


In this investigation the boundary integral equation (BIE) method with numerical evaluation of the boundary integral equations is applied to the analysis of simply supported plates of any shape, resting on an elastic foundation. The numerical results are compared with those available from analytical solutions. Moreover, the efficiency of the BIE method is demonstrated and examined.


Leen De Coninck, Joris De Schepper, Lien Beyls, Patricia Claessens Artevelde University College Ghent, Belgium Background In preventive care, compliance is not only a patient problem, but also a problem in terms of the health worker. When developing a preventive program, the attitude of the health worker must be taken into account. Falls in elderly people becomes an enormous problem. In retirement homes, fall-related injuries are frequently the cause of death of elderly people. A multi factorial intervention program is effective to reduce the rate of falls. Despite the evidence, a fall prevention program doesn't always present the desired result. One of the reasons is the lack of compliance of the health worker.


One aspect of the present invention comprises (a) an anti-inflammatory / antioxidant conjugate; And (b) an insulin secretagogue, insulin sensitizer, alpha-glucosidase is let inhibitors, peptide analog, or a pharmaceutical combination comprising a combination thereof. Another aspect of the invention relates to a method of treating a metabolic disorder in these conjugates.


than a little while ago. They will certainly be in dispute because no one form of marxism is agreed; probably sectarian because they will still be small groups lacking power and confined to words. Many changes demanded by the New Left have now been accepted because they met a real situation; others have been abandoned by marxists, being in effect varieties of philosophical idealism. The taking up of overseas fashions in marxism is likely to be less common as the experience accumulates to answer Australian problems. Culturally the most relevant consideration will continue to be the powerful attraction of the history of Australia, which is too deep seated to be reversed or even level off in the near future. It is a consequence of many causes, an intersection of forces which date from earlier nationalism and World War II with those that reflect the confident 1950s and 1960s and the search for a national identity in a changed world. It is sharpened by the contrast with the lack of real national independence so it embodies aspirations as well as interest in the past. The output of Australian history will make available to labour This content downloaded from 220.127.116.11 on Sat, 03 Sep 2016 03:56:50 UTC All use subject to http://about.jstor.org/terms AUSTRALIAN LABOUR HISTORY 133 historians much work which impinges on their own, enabling them to get closer to the ideal of writing the history of society. It will give them more scope and invite them to become more concerned with interpretations and critical reas sessment of received explanations. Some themes are likely to continue to be prominent. The complexities of the processes of class relationships and a recognition of the diversity of the Australian working class at each historical stage is one of them, linked with the formation and operation of ideologies. These will be problems of the future as well as historical phenomena. For these and for other themes it is likely that the concentration on Australia internally, which was necessary to distinguish Australian history as a field of study, will be modified by attention to Australia within world imperialism. Much scope remains for the examination of racism and current concerns will call it forth. There the parameters of the debate are already established. Women's history has an open future both in itself and for integration into wider history of society. The exercise of state power is likely to become more stringent, the existence of deprived and oppressed groups more obvious; so processes of social control and conflict will come under scrutiny. Thus the widening of labour history into social history will continue whilst much of the indiscriminate collection in the name of social history drops into the category of reportage. The ebbing of the voguish element will leave behind a fruitfully broadened field of subject matter and a heightened awareness of social relations. I have been referring to prospects in academic labour history. I would foresee a fairly spontaneous growth of popular labour history of many types, merging into oral history, arising from shared experiences ? political, work, local. This could become common without any strong organization being necessary. I assume that all the existing types of labour history will continue, as will the pluralist situation in which they coexist. Nothing lasts forever, but I am referring to a period (how long I would not attempt to guess) without dramatic changes politically or ideologically: a period that should witness an extension and strengthening of labour history. That in turn will test existing organiza tions. There are limits to the central role of Labour History and its parent society as the whole labour history scene becomes larger and more diversified. No doubt groups with some degree of cohesion and political commitment will be able to present their own historiography. At the same time labour historians are gaining a larger place in the writing of history as a whole. Both processes will continue. / am indebted to Dr. John Merritt for making available to me his chapter, "Labour History", in New History, G. Osborne and W.F. Mandle (eds.). I have also drawn on a paper, "Labour History in Australia", by E.C. Fry and A.B. Davidson, presented at a World Forum on Labour History, Paris, 1980. This content downloaded from 18.104.22.168 on Sat, 03 Sep 2016 03:56:50 UTC All use subject to http://about.jstor.org/terms 134 LABOUR/LE TRAVAILLEUR


A fetus is described with anophthalmia, absent pituitary, hypoplastic adrenal glands and kidneys, absent left horn of the uterus, underdeveloped genitalia, and clinodactyly, with a deletion of 14(q22q23). A review of published reports found no similar deletion cases.


This paper designed a multi-objective function of resource leveling and created the multi-resources leveling model on the basis of particle swarm optimization algorithm.The model combines multi-resources leveling in project network planning with particle swarm optimization algorithm,and searches for the position corresponding to the optimal solution activity actual start time through the flight during the evolutionary process.The objective function can better reflect the degree of multi-resources leveling by an example.Also the paper found that the particle swarm algorithm has characteristics of high precision,more ideal calculation and close to the actual.The results reflect the feasibility and effectiveness in the multi-resources leveling for project management.The proposed algorithm is valuable in practical application for the multi-resource leveling optimization in engineering project management.


Modern society development requires practice of creative education. The principal part of knowledge creation is talents with creative spirit and ability. And the growth of talents relies on education, so it's accordingly necessary to construct a teaching staff with creative quality. Creative education demands that teachers should build up creative education ideas, possess creative spirit, ability and personality.


Alternaria alternata has been responsible for causing leaf spot diseases in various host species. Methanolic extracts of six selected plant leaves viz Parthenium hysterophorus, Vernonia amygdalina, Eucalyptus camaldulensis, Nerium oleander, Lantana camara and Ocimum sanctum were in vitro screened for their antifungal activity against A. alternata at 5, 10 and 20% concentrations. Highest reduction in mycelial growth was achieved by Oleander followed by Parthenium, Ocimum, Lantana, Vernonia and Eucalyptus, respectively. Thin Layer Chromatography (TLC) was carried out by using solvent system of Toluene: Ethyl acetate: Formic acid (3:1:2) to separate the compounds responsible for antifungal activity. Phytochemical analysis of leaf extracts revealed the presence of Alkaloids, Terpenoids, Phenols, Saponins and Tannins at various concentrations.


Abstract We describe the finding of unsuspected aortic coarctation, discovered by catheterisation at 4 months, in a neonate first daignosed on the fourth day of life as having tetralogy of Fallot with pulmonary atresia and major aorto-to-pulmonary collateral arteries. This previously unreported combination contravenes the established theory of patterns of flow during fetal life, and presented difficult issues in clinical management.


The projected fossil fuel deposits depletion by near future and detrimental effects of petroleum products on environment has led to the development of volatile organic compound (VOC) free low molecular weight sustainable polymers, with promising applications in field of inks, adhesives, paints, and coatings. In view of this, present study reports synthesis, characterization, and anticorrosive performance of SMG-PU and modified SMG-PU through in situ formed silica networks (SMG-PU-TEOS) OIH polymer nanocomposite coatings on CS. The size of ∼30 nm silica nanonetworks were formed within SMG-PU on addition of TEOS, inducing thermal stability, hydrophobic, improved physicomechanical and corrosion resistant properties to polymer nanocomposite coatings. The corrosion protective performance of these coatings in 5% NaCl (salt mist test), 3.5% NaCl, and 3.5% HCl solutions revealed very lower Icorr values (3.8891 × 10–10 A cm–2 and 6.8756 × 10–9 A cm–2) as compared to SMG-PU (1.8159 × 10–8 A cm–2 and 9.1396 × 10–7 A...


On 16 May 2009, the 13th general election for the National Assembly (Majlis al-Umma) was held in Kuwait. Over the past three years, the Assemblies were dismissed and the general elections were held three times in 2006, 2008, and 2009, although the term of office of the Assembly is four years. The 2006 election was the first election conducted under the new system in terms of change in the electoral districts and the enfranchisement of women. The electoral and the nationality laws, which affect the definition of constituencies, have frequently been altered throughout the history of Kuwaiti politics. Although the government initiated some alterations to the electoral systems and the Assembly led others. A comparative political analysis of the outcomes regarding changes to the political system, the other factors should be constant; in other words, in an examinationon changes to the political balance caused by changes to the parliamentary system in Kuwait, at least the political forces are required to be defined. In recent studies, some researchers have argued that virtual party politics has developed in Kuwait, although the formation of any political party is formally forbidden [Brown 2007; Ishiguro 2008]. Political goups in Kuwait, however, are not defined well enough to be analyzed through comparative politics. Therefore, this paper examines the changing parliamentary system and its outcomes by focusing on the characteristics of the political actors involved in Kuwaiti politics. The purposes of this paper are as follows. First, we aim to analyze the frequent changes in the electoral system and the intentions and strategies of the political actors, such as the ruling family and the members of parliament, and the outcome of the change to the system. An analysis of these attributes leads to the second section that focuses on three case studies.


Introduction Disabling chronic low back pain (CLBP) is associated with negative beliefs and behaviours, which are influenced by culture, religion and interactions with healthcare practitioners (HCPs). In the UK, HCPs encounter people from different cultures and ethnic backgrounds, with South Asian Indians (including Punjabis) forming the largest ethnic minority group. Better understanding of the beliefs and experiences of ethnic minorities with CLBP might inform effective management. Objectives To explore the CLBP beliefs and experiences of English-speaking Punjabi and white British people living with CLBP, explore how beliefs may influence the lived experience of CLBP and conduct cross-cultural comparisons between the two groups. Design Qualitative study using semistructured interviews set within an interpretive description framework and thematic analysis. results Participants from both groups held negative biomedical CLBP beliefs such as the 'spine is weak', experienced unfulfilling interactions with HCPs commonly due to a perceived lack of support and negative psychosocial dimensions of CLBP with most participants catastrophising about their CLBP. Specific findings to Punjabi participants included (1) disruption to cultural-religious well-being, as well as (2) a perceived lack of understanding and empathy regarding their CLBP from the Punjabi community. In contrast to their white British counterparts, Punjabi participants reported initially using passive coping strategies; however, all participants reported a transition towards active coping strategies. Conclusion CLBP beliefs and experiences, irrespective of ethnicity, were primarily biomedically orientated. However, cross-cultural differences included cultural-religious well-being, the community response to CLBP experienced by Punjabi participants and coping styles. These findings might help inform management of people with CLBP.


The insular cortex consists of a heterogenous cytoarchitecture and diverse connections and is thought to integrate autonomic, cognitive, emotional and interoceptive functions to guide behaviour. In Parkinson's disease (PD) and dementia with Lewy bodies (DLB), it reveals α‐synuclein pathology in advanced stages. The aim of this study is to assess the insular cortex cellular and subregional vulnerability to α‐synuclein pathology in well‐characterized PD and DLB subjects.


Background and Objectives:Angiotensin converting enzyme inhibitors (ACEI) have been suggested to be beneficial in regurgitant valvular heart disease by reducing both preload and afterload. Moreover their benefits have also been proven in acute mitral regurgitation (MR). However the role of long term administration of ACEI in chronic MR remains in dispute. Subjects and Methods:One hundred patients with more than moderate degree MR (rheumatic MR or Mitral valve prolapse [MVP] MR) were identified from patients undergoing cardiac echocardiography between April 1984 and July 2002. Patients with co-morbid valvular heart disease more than mild degree were excluded from the study. The subjects were divided into the study group (who took ACEI) and the control group. Medical records and echocardiographic reports were reviewed and the etiology of MR, left ventricular end-diastolic dimensions (LVEDD), end-systolic dimensions (LVESD), left atrial dimensions, and ejection fraction (EF) changes were studied serially for both groups. Results:The mean duration of follow-up was 5.0± 3.2 years. There were no significant differences in age, blood pressure, or basal echocardiographic parameters between the rheumatic MR and MVP MR groups. In the MVP MR patients, the ACEI group showed a statistically significant increase in EF (p=0.007), decrease in LVESD (p=0.0014) and decrease in left atrial dimensions (p=0.01). However, in the rheumatic MR patients, the ACEI group showed no significant changes compared to those of the non-ACEI group. Conclusion:Long term ACEI therapy seems to be beneficial in mildly symptomatic MR due to mitral valve prolapse. (Korean Circulation J 2004;34 (2):159-169)


During the past 60 years clinical psychology training programs have made remarkable changes as psychologists' professional roles and scientific contributions have emerged. Yet, there are a number of issues that have implications regarding the quality of research training in PhD programs. Current PhD programs are encouraged to offer a joint PsyD/PhD training program when their goal is to train researchers and clinicians who would be eligible for licensure. It is recommended that the PhD serve only as a research degree. A joint PsyD/PhD addresses many of the identified problems and issues. It conserves resources for research training and explicitly identifies, recognizes, and rewards the training that is required. It may best serve to advance the knowledge base of clinical psychology.


Preface 7th Symposium on Mechanics of Slender Structures 2017 (MoSS2017) I Herrera1 S Kaczmarczyk2 1University of Extremadura, Spain, e-mail: firstname.lastname@example.com 2The University of Northampton, UK, e-mail: email@example.com This issue of Journal of Physics: Conference Series contains selected technical papers that were presented at the 7th Symposium on the Mechanics of Slender Structures (MoSS2017) and show a range of different approaches used in the analysis of slender structures. The meeting was hosted by The Lift Engineering Research Center (INGELEV) of the University of Extremadura, and was held in Mérida, Spain, from 14th to 15th December 2017. This conference runs under the auspices of the Institute of Physics Applied Mechanics Group and forms a continuation of a successful meeting series on the Mechanics of Slender Structures first held in Northampton, UK, in 2006, followed by the event hosted in Baltimore, USA in 2008, in San Sebastian, Spain in 2010, in Harbin, China in 2013, in Northampton, U.K. in 2015 and in Shanghai, China in 2016.


A Lauritsen electroscope was used to compare the intensity of an Ir192 source with a radium standard. The result of a least squares fitting of the decay curve was a half-life of Ir192 of 74.37 ± 0.07 days.


The article deals with the basic conditions of moral and spiritual upbringing of students in the study of the fundamentals of science. Particular attention is paid to the forecasting of goals and ways of implementing them. This makes it possible to consider education as a system and its designing in the training system for the development of students as members of the spiritual realm.


This study focuses on the structural properties of Eu doped borosilicate glass relevant for investigations of incorporation behaviour of radioactive nuclides in highly radioactive vitrified waste (HLW). Borosilicate glasses containing different amounts of Eu(III) were investigated by two complementary spectroscopy techniques time-resolved laser fluorescence spectroscopy (TRLFS) and high resolution X-ray absorption spectroscopy (partial fluorescence yield X-ray absorption near edge structure, PFY-XANES). Eu has excellent photoluminescence properties and therefore we chose it for these structural studies as a representative of trivalent lanthanides and a nonradioactive analogue of trivalent actinides. The combination of XAS and TRLFS allows characterization of the electronic and local geometric structure of the Eu(III) species embedded into the glass matrix. The obtained knowledge will be transferred to other Ln(III) and An(III) borosilicate glass systems [1]. PFY-XANES results presented here demonstrate a greater sensitivity and more resolved spectral information compared to the standard XAS technique (total fluorescence yield-XANES, TFY-XANES) [2].


There are three important factors in the emergence or re-emergence of infectious diseases: microbial factors, host factors and factors related to the transmission of microbes. This paper will review host natural and adaptive defense mechanisms and discuss experimental evidence regarding the effectors of endocrine and metabolic responses to infection.

External defense mechanisms protect against the first step in infection, entry of the pathogen into the host. The skin is a very powerful barrier to most infectious agents, and although mucosal linings of the respiratory, gastrointestinal and urogenital tracts are more delicate, they have the advantage of specialized defense mechanisms, such as the secretion of factors like immunoglobulins and mucus, and the sweeping action of cilia. Together these external defenses are of the utmost importance to hosts vulnerable to infection.

If a pathogen succeeds in entering the body, the next step in host defense is natural immunity (Table 1). Natural immunity is less sophisticated than adaptive immunity, but it is a very important defense against all types of infection in many animal species. The principal cellular components of natural immunity are phagocytes, such as macrophages, neutrophils, natural killer cells and mast cells; the principal soluble factors are components of the complement cascade, interferon and acute-phase reactants. Humoral factors are of differing importance in different types of infection, due, in part, to the fact that microbes have evolved a variety of different mechanisms to escape the host's natural defenses.

View this table:

Table 1
Host defense mechanisms against infectious agents

The third line of defense in higher vertebrates is adaptive immunity which is specific to the invading organism. It is a tailor-made defense system. Three types of cells — antigen-presenting cells, such as macrophages, T cells and B cells — are involved in adaptive immunity. The relative importance of cellular immunity, mediated by T cells, or humoral …


In this study, the possible climate change impacts on irrigated corn production in the Lower Mississippi Delta (LMD) region were analyzed. The observed daily maximum and minimum air temperature, wind speed, relative humidity (RH), and precipitation from 1960 to 2018 were used in the analysis. The length of the growing season, evapotranspiration (ET) and crop yield estimates from the pre-calibrated Root Zone Water Quality Model (RZWQM) were also used. Trend analyses were performed on growing season averages for temperature, RH and wind speed; growing season totals for precipitation and ET; daily values of minimum and maximum temperature; and averages of RH and wind speed at critical corn growth stages. The last day of spring freezing (LDSF) and days with an average daily air temperature (Ta) of more than 35 °C during corn silking were also included in the analysis. The trend analysis was performed using the modified Mann-Kendall test, Pettitt test and Sen's slope at a significance level of p ≤ 0.05. The results from our study pointed out increases in minimum Ta, increases in the number of days with Ta exceeding 35 °C during the corn silking stage, increases in RH and decreases in ET, advancement of the LDSF by two weeks, and 8% reductions in corn yield that could be attributed to changes in climate. If the observed trends in climate (climate variability and change) and yield reductions continue in the region, it could be challenging to grow the corn crop in the LMD profitably.


The clinical anatomy of the anterior abdominal wall and syntopy of its surface neurovascular are worked out in detail. On the basis of this the method of low traumatic median laparotomy and the method of selective drainage of the postoperative wound taking into account preservation of basic neurovascular fascicles of the anterior abdominal wall are developed and introduced.


Processing of most action goals and complete perception of the environment, like spatial localization of events, require integration of information from different sensory systems. The classical idea of a hierarchical sensory organization is challenged by recent evidence from both human and primate work showing that multisensory processing is already taking place in primary sensory cortices. However, the mechanisms underlying this multisensory processing and the role of primary sensory cortices in crossmodal communication and oscillatory coupling remain largely unknown. Congruent and incongruent uni- and bimodal visual (light spot) and tactile (whisker deflection) stimulation was performed simultaneously with extracellular multielectrode recordings in the primary visual (V1) and somatosensory (S1, barrel field) neocortices of adolescent Brown Norway rats in vivo. Tactile stimulation led after 10–30 ms to a phase-locked, large amplitude response in the contralateral S1 that is accompanied by prominent, layer-specific sinks and sources. Additionally, non-phase-locked oscillations were induced in different frequency ranges. Visual stimulation alone did not change the amplitude of oscillations compared to baseline activity in the contralateral S1, but reset the phase of ongoing oscillatory activity. Because of the visual impact in the S1, bimodal congruent stimulation led to an increase of the evoked response and changed the timing of amplitude enhancement of oscillations. These data indicate that networks in the barrel cortex are modulated by crossmodal visual input.


The cross-hole seismic survey technique is presented as a means of determining in situ shear wave velocity. By this method the travel time for body waves to travel between two points in a soil mass is measured. Body waves may be either compression or shear waves. Emphasis is placed on identification of the shear wave because it is directly used to calculate the dynamic shear modulus of the soil and can be measured above or below the water table. A general procedure followed in performing the test is described. Typical travel time records of arriving energy are shown and identification of the compression and shear wave arrivals made. Preliminary tests demonstrating the validity and use of the method are presented. Three case studies using the method under various field conditions are also presented.


The locus is a very important concept in Euclidean geometry since it serves as a tool for solving different problems, and allows geometric constructions to be carried out. The teaching of the subject of loci in various mathematics courses includes solution of different exercises in which the student is required to find the locus in accordance with the data of the question. The present paper offers a different view of the subject of loci, which brings about conceptual understanding of the subject with identification of conserved properties and suitable generalizations obtained through investigation that includes the use of dynamic geometric software (GeoGebra). General formulas were developed for the equation of the locus in two cases. In the article, there are links to geometric applets which allow one to demonstrate the loci formed in some cases.


6009 Background: Although we recently observed that introducing palliative care soon after diagnosis for patients with metastatic NSCLC is associated with better quality of life, mood, and survival, the degree to which this care model impacts medical treatment at the end of life requires further study. The aim of this follow-up analysis was to examine the effect of early palliative care on the frequency and timing of chemotherapy utilization and hospice care among patients with metastatic NSCLC.

METHODS
In this randomized controlled trial, we enrolled 151 patients with newly-diagnosed, metastatic NSCLC presenting to the Massachusetts General Hospital Cancer Center between 6/06 and 7/09. We randomly assigned patients within eight weeks after diagnosis to receive early palliative care integrated with standard oncology care (N=77) or standard oncology care alone (N=74). Participants in the intervention group consulted with palliative care clinicians at least monthly until death. Using Fisher's exact and log-rank tests, we analyzed differences in the: 1) number and types of chemotherapy regimens; and 2) frequency and timing of chemotherapy administration and referral to hospice care.

RESULTS
By one-year follow up, 128 (84.8%) participants had died. Study groups did not differ significantly with respect to the number of chemotherapy regimens or time to second-line or third-line administration. However, compared to those in the standard care group, participants receiving early palliative care had a lower rate of intravenous chemotherapy utilization within 60 days of death (24.1% vs 47.0%, p=0.009), a longer interval between the last dose of intravenous chemotherapy and death (median days=64 vs 41, p=0.01), and higher enrollment in hospice care for greater than one week before death (59.6% vs 33.8%, p=0.006). Early palliative care did not impact utilization of oral chemotherapy.

CONCLUSIONS
Although patients with metastatic NSCLC received similar numbers of chemotherapy regimens in the sample, early palliative care optimized the timing of final administration of intravenous chemotherapy and transition to hospice services, key measures of quality end-of-life care.


As a provincial centre for remote sensing in Shanxi, it has developed its integrated remote sensing and GIS system for agricultural resource assessment and monitoring in the Province with a very complex loess highland landscape, segmented land parcels and multi-diversity crops. The structure of the system was designed such that it can be readily updated to integrate the remote sensing (TM and CB-1) and other types of agricultural information needed for timely agricultural monitoring and assessment. In addition to introduce the structure and application of the system, this paper will focus on the innovative methods implemented in the system for improving interpretation accuracy and minimizing the information loss due to resampling process involved in fusing multiple images and the resolution alteration. The key issues we address here include multi-scale processes. The systems can readily handle problem in various scales such as province, city and county scales; (2) Determination of 100m /spl times/ 100m as the optimum re-sampling resolution for fusion and integration of various data for the application in the province scale. The resolution has been shown adequate both for the analysis and for the capacity of the facility available at the centre; and (3) Integration of GIS and RS to assist the information extraction, classification and identification of features.


The aim of the present research is the shaping of zeolite 13X and study the effect of singular and binary system of binders. For this purpose, zeolite 13X was successfully synthesized under hydrothermal conditions. Different combinations of polyvinyl alcohol (PVA) and polyethylene glycol (PEG) have been used for shaping. Physical properties of granules were measured by nitrogen adsorption-desorption and results showed that increasing the binder content up to a certain amount, enhanced the physical properties but with a further increase in binder content surface area decreases. Also it was found that mechanical strength was decreased with increasing binder content after burnout


OBJECTIVE:To improve undergraduate students' self-learning ability,scientific thinking,and application skills.METHODS:Team-based learning(TBL),problem-based learning(PBL),scenarios simulation and other teaching methods and techniques were adopted,and evidence-based medicine concepts were introduced in the teaching process. RESULTS:Students improved learning interest and self-learning ability,and they also realized that some theories in pharmacology textbooks could be rectified or improved by the research results of evidence-based medicine. CONCLUSIONS:The application of multiple teaching methods is helpful to enhance students' self-learning ability,to prove it is positive to introduce evidence-based medicine concepts,and to cultivate students' scientific and critical thinking spirit in pharmacology teaching process.


In order to study the effect of acupuncture on the recovery of fatigue after strenuous exercise, the RPE and DDS of the 22 subjects were tested. The results indicated a quicker recovery from fatigue in acupuncture group after a 7-day continuous training, and indexes of RPE,DDS,SR and PT/BW in acupuncture group were significantly lower than those in control group ( P 0.05).


Delays in supply chains due to decision making (of managers) and lead time (in production) cause undesirable effects to inventory levels. Via system's thinking, key mechanisms leading to such effects are investigated by analyzing the stability of an inventory, departing from a commonly studied model. On this model, two distinct delays and a PI controller to remove offset in inventory, are incorporated. On the plane of delays, stable and unstable operational behavior of inventory level are identified on so-called stability maps. Next, effects of PI controller to stability are revealed and this controller is optimized for avoiding oscillatory nature of inventory level. Case studies are provided to demonstrate counter-intuitive effects of delay presence to supply chain management and how stability maps may serve as decision-making tools for managers in achieving better control on inventory behavior.Copyright © 2008 by ASME


As is well known, the amount of aid given by international donors both to Israel and to the occupied Palestinian Territories (oPt) is unparalleled in the world, but the fact that people can turn violent against their own CSOs trying to promote reconciliation speaks abundantly about the resentment that external aid can generate. Studying the nexus EU-civil society-Palestinian-Israeli conflict cannot therefore be done without a general overview of the particular setting in which aid for conflict transformation takes place. This report is articulated in four parts. The paper first briefly discusses the nature of the conflict and recent trends in its development, affecting, inter alia, the domestic context in which civil society operates. It then looks at the EU's involvement in the conflict and presents the tools that the EU uses in its support for civil society. Moving on, it analyses the impact and effectiveness of Israeli and Palestinian civil societies (with a view on CSO typologies and activities) and suggests why the effectiveness of civil society has remained limited. Finally the paper deals with the EU's impact and the role of EU-funded programmes supporting civil society involvement in conflict transformation, testing the different hypotheses outlined in the guiding report issued for this work package.


A 15-year-old girl was admitted to the E.N.T. Department of the Rothschild Municipal Hospital, with a history of nasal obstruction and chronic rhinitis of several years' duration. Interference with nasal breathing started about 5 years before admission and had slowly progressed to complete occlusion. Concurrently the sense of smell was lost. Past history was entirely non-contributory, except for a transient squint 1 year before admission. Nasal obstruction in early childhood was denied by the parents; Menarche, with regular menstrual periods, since the age of 13 years. She was a well-developed girl in good general condition. There was an almost complete obstruction of both nasal fossae, which were filled with thick mucous. Oropharynx, ears and hearing were normal. Her voice was nasal and sense of smell was absent even for strong odours. After suction of nasal discharge and shrinkage of the mucous membranes, the nasal septum could be seen deviating to the left. At a depth of about 4 cm. both nasal fossae were occluded by a round bulging structure covered with normal mucosa. A narrow slit at the floor of the nose permitted passage of a probe into the pharynx. The bulges appeared like a pair of breasts intersected by the nasal septum. Their walls were of bony consistence. A large round tumour covered with smooth mucosa filled the nasopharynx, resting on the palate and visible already when lifting the uvula. Digital palpation ruptured the tumour and a fair amount of thin pinkish fluid escaped. Nasal breathing immediately improved, but only for a few hours. Lateral X-ray pictures of the skull demonstrated a large cystic tumour, the walls of which were outlined by egg-shell like calcifications. It extended anteriorly to the middle of both nasal cavities, superiorly and posteriorly above the enlarged sella turcica and inferiorly into the nasopharynx and to


ABSTRACT This paper explores the role of the Catholic Church in the articulation of populist discourse. By analysing the frames in Catholic doctrines and their dissemination by the Croatian clergy, I make three contributions. Firstly, in contrast to research on the populist radical right, which demonstrates the manipulation of religion committed by secular actors, I identify the Church as an influential source and producer of the populist master frame. Secondly, I demonstrate how the bridging of the 'gender ideology' frame to this populist master frame allows the national Church to articulate traditionalist stances on morality policies. Thirdly, I identify the local-level argumentation strategies, empowered by frame bridging with anti-communist, nationalist, and sovereignist themes typical of radical-right populism. Focusing on religious actors' agency allows us to improve theories rooted in the secular world of populist politics that neglect churches as important sources of populist discourse and mobilisation.


OBJECTIVE
To investigate the diagnostic value of deep learning (DL) in differentiating otitis media (OM) caused by otitis media with effusion (OME) and primary ciliary dyskinesia (PCD), so as to provide reference for early intervention.

METHODS
From January 2010 to January 2021, 31 patients with PCD who had temporal bone computed tomography (TBCT) in the Children's Hospital of Fudan University were retrospectively analyzed. Another 30 age-matched cases of OME with TBCT were collected as the control group. The CT imaging signatures of children were observed. Besides, a variety of DL neural network training models were established based on PyTorch, and the optimal models were trained and selected for PCD screening.

RESULTS
The google net-trained model worked best, with an accuracy of 0.99. Vgg16_bn, vgg19_bn, resnet18, and resnet34; having neural networks with fewer layers, better model effects, with an accuracy rate of 0.86, 0.9, 0.86, and 0.86, respectively. Resnet50 and other neural networks with more layers had relatively poor results.

CONCLUSION
DL-based CT radiomics can accurately distinguish OM caused by OME from that induced by PCD, which can be used for screening the PCD.


The authors report the influence of the kink effect on the DC and microwave performance of i-InAlAs heterojunction doped-channel MESFETs lattice matched to an InP substrate with submicrometer gates. Kink effects were observed at room temperature as well as at 77 K in the DC measurement. The kinks seem to be related to deep-level electron trapping, and are not present at microwave frequencies. Measured results are presented showing that the existence of kinks at low operating frequencies does not seem to degrade the microwave performance of the devices.<<ETX>>


This paper is based on the findings of a 3-year, qualitative study funded by the Research Consortium on Educational Outcomes for Poverty. It uses Sen's [1985. Well-being agency and freedom. Journal of Philosophy 82, no. 4: 169–221] capability approach and Bourdieu's [1991. Language and symbolic power. Cambridge, MA: Harvard University Press] critical theory to argue that access participation and the empowering outcomes of higher education are contingent on learners' familiarity with the languages used. If there is a discrepancy between the languages used in higher education and the linguistic capital that learners have acquired during schooling without any appropriate measures to fill the gap, participation is bound to be limited. Findings of this qualitative multiple case study involving eight participants entering higher education from government and private schools in Pakistan reveal that working-class women remain the most marginalised and fail to achieve valued goals within higher education in terms of knowledge construction, participation, and a more empowered sense of identity. This eventually culminates in their delayed elimination from higher education.


•  Introduction •  HATs/HDACs and the pro‐inflammatory environment •  HATs/HDACs and endoplasmic reticulum (ER) stress •  The potential role of histone deacetylase inhibitors in the treatment of cancer ‐  Non‐small cell cancer (NSCLC) ‐  In vitro evidence for targeting HDACs in NSCLC ‐  Combinatorial therapies involving HDi in NSCLC ‐  Hepatocellular carcinoma (HCC) ‐  In vitro evidence for the use of HDi in liver cancer ‐  Combinatorial treatments involving HDi in hepatoma •  Potential role of histone deacetylase inhibitors in the treatment of diabetes ‐  Disease models, knockouts and assays ‐  Pancreatic islet protection using histone deacetylase inhibitors ‐  Additional in vitro evidence ‐  Stem cells, HDACs and histone deacetylase inhibitors •  The potential role of histone deacetylase inhibitors in the treatment of neurodegenerative conditions ‐  Neuronal traits are modulated by HDAC/REST complexes ‐  E2F, HDACs and neuronal survival mechanisms ‐  HDACs play important roles in stem cell neuronal differentiation •  Histone deacetylase inhibitors ‐  SAHA (vorinostat) ‐  Phenylbutyrate ‐  Valproic acid ‐  AN‐9 ‐  CI‐994 ‐  Romidepsin ‐  MS‐275 ‐  LBH589 (panobinostat) ‐  MGC D0103 •  Caveats ‐  Do HDAC inhibitors target genes or help chaperone activity as their primary response? •  Final comments


into a costly, long-term guerrilla war. Second, Scott also showed, through his willingness to momentarily halt his offensive after key battles, that he wanted not to conquer Mexico, but instead to convince her leaders to accede to American demands. "This study argues" writes Johnson, "that [Scott] devised a sophisticated pacification plan . . . and a strategy of moderation" (p. 5). Scott's leadership also marked a huge step in the professionalization of the United States Army. With many West Point graduates (and future Civil War generals) in his ranks, Scott relied on their knowledge and expertise to negotiate the rough terrain and battlements that marked his route. In so doing, Johnson also credits Scott with being uniquely able to overcome what Prussian military theorist Carl von Clausewitz called the "friction" of war (p. 3). Johnson relies on more than 150 primary sources, both published and unpublished, to tell his story. As such, the narrative comes alive with the comments of men and officers alike. One such story, which fits with Scott's demand for army discipline, comes from young Lt. Ambrose Powell (A.P.) Hill. At one point on the march to Mexico City, Hill's fifty mounted volunteers were ordered to stay behind as a rear guard. Anxious to move up, some of his men made ready to ride ahead in violation of orders. Hill himself mounted up to block his men. "His appearance alone should have been sufficient to keep the men in line," writes Johnson. "He wore a sombrero, a 'flaming red flannel shirt,' red-trimmed boots, and an 'immense pair of Mexican spurs,'" along with four pistols, a butcher knife, and a saber. "I was as villainous a looking rascal as ever there was," Hill commented (p. 247). His men relented. Civil War buffs will recognize this as the start of Hill's habit of wearing a bright red shirt into battle. The book features a selection of maps which are vital to visualizing the campaigns about which Johnson writes, and a wealth of material in appendices, such as officers attached to Scott's command and men who were wounded or killed in battle. Again, this book is a pleasure to read and highly recommended.


A system to provide eye or sensor protection from laser-beam damage is investigated. Light beams exceeding a safe energy density are prevented from reaching the observer or sensor by the destruction of a mirror in the line-of-sight. The replaceable mirror consists of a 10- to 20-nm vacuum-deposited metal film on a 2- to 8-micrometer black plastic substrate. The mirror is vaporized directly by focusing the input beam on it. The vaporization, which occurs fast enough to protect against Q-switched lasers, prevents the potentially damaging radiation from reaching the eye or sensor. The energy reflected by various prototype limiting mirrors is measured as a function of the incident energy in an experimental arrangement employing 1-J Q-switched and normal-pulsed ruby, and 2-W CW argon laser beams. (GRA)


The purpose of this paper is to show some thoughts on capitalism's axiomatic, which decodes all conventions of "uncivilized" societies, and fulfills the promises of despotic and "barbarous" societies, partially updating the despotic delusions of grandeur of the modern States. Simultaneously, capitalism creates a proliferation of regional and territorial fractures as well as globalization of all kinds. In this total decoding and trans-mutation of values, the flows (social, economic, and political) released by capitalism falter in front of a decoding that would lead, on the one hand, to a radical "de-territorialization" of the processes and, on the other, to a conservative resurgence and updating of these flows produced by the process of "destructive creation".


Cardiovascular disease is the leading cause of mortality in women. Pregnancy is an ideal period to implement cardiovascular prevention strategies as women seek medical help. We aimed to develop a predictive model to identify women at increased risk for chronic hypertension (CH) based on information collected in the index pregnancy.

 Cohort of 26 511 women seen in 2 consecutive pregnancies. Included were women without CH, with information on maternal characteristics and blood pressure at 11 to 13 weeks' gestation, and the development of preeclampsia or gestational hypertension (GH) in the index pregnancy. Logistic regression models were fitted for the prediction of the development of future CH by the 20th week of the subsequent pregnancy. The performance of screening and risk calibration of the model were assessed.

 1560 (5.9%) women developed preeclampsia or GH (index pregnancy), and 215 (0.8%) developed future CH, with a median of 3.0 years later. Predictors of development of future CH were maternal age, weight, and blood pressure; Black and South Asian ethnicity; family history of preeclampsia; parity; and development of preeclampsia or GH. Preeclampsia or GH detected 52.1% (45.2%–58.9%) of future CH. At a screen-positive rate of 10%, a model including maternal characteristics, early pregnancy blood pressure, and development of preeclampsia or GH detected 73.5% (67.1–79.3) of future CH.

 Early pregnancy maternal characteristics, blood pressure, and development of preeclampsia or GH identify three-fourths of women at risk for future CH. Our results offer an important preventative strategy for identifying women at increased risk of future CH, which is applicable worldwide.


Objective To determine the influence of recombinant human relaxin (rhRLX) on collagen gene expression in cardiac fibroblasts (CFs) under high glucose (HG) conditions. Methods CFs were isolated from Sprague-Dawley rats and cultured primarily. The mRNA levels of type Ⅰ,type Ⅲ collagen and RLX in CFs after 3 passages under normal glucose (NG,5.6 mmol/L) and high glucose (HG,25 mmol/L) conditions were assessed by RT-PCR. rhRLX (100 μg/L) was cocultured with CFs under NG and HG conditions for 72 h respectively,then the mRNA levels of type Ⅰand type Ⅲ collagen were detected. Results HG increased the expression of type Ⅰ and type Ⅲ collagen,which was inhibited by rhRLX. The RLX mRNA expression was stronger in HG group than in NG group. Conclusion rhRLX inhibits the HG-enhanced overexpression of typeⅠand type Ⅲ collagen.


Blood glucose monitor inaccuracy can lead to insulin dosage miscalculations, failure to detect episodes of hypoglycaemia and the potential for worsening of long-term complications of diabetes.


Burnout is a serious and growing condition in emergency medicine, and as the article suggests, it is significantly underrecognized. While the article is laudable in many respects, the authors do not spend much time discussing the ethical and professional implications of discovering serious negative mental states in residents as part of their study. How was this sensitive information handled after it was discovered? Were the residents informed if they tested positive or informed that their mentor thought they were burned out? Was the residency leadership or was their mentor informed of their status? Given this incredible sensitive information and its potential implications we think that it is important for them to comment on the consent process and the guidance they received from the human subject review board to make the article stronger in its own right and for setting precedent for future investigations. Matthew L. Wong, MD, MPH and Edward Ullman, MD Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA. (email@example.com)


With the establishment of China-ASEAN Free Trade Area,economic globalization,the regional economic integration and urban development cooperation,the border cities in both China and Vietnam have become the rising centers of growing regional economy and trade.The"theory of cross-border integration development"applied in Sino-Vietnamese border cities is believed to be a important way to achieve co-prosperity of these cities and the local regions.The study takes the integration development of Dongxing in China and Moncay in Vietnam as examples to discuss the objective basis and feasibility of the theory.It also makes a tentative research into the possible fields of the integration and related effects on the local region.


An all-fiber approach is utilized to phase lock and select the in-phase supermode of compact 19- and 37-core fiber lasers that are a few cm long, aligning-free in operation, and environmentally robust.


Deep vein thrombosis and its progression to pulmonary thromboembolism is a major source of mortality in patients with neuromuscular disease. Furthermore, ventilator use poses a high risk of DVT to patients.


Pyrolysis the waste plastic into fuel is a promising way to protect the environment. In this study, we study the thermal decomposition processes of polymer Poly (methyl methacrylate) PMMA. This work used the microscale combustion calorimeter (MCC) as a tool to study the degradation. MCC is an applicable method to calculate the material combustion parameters by using milligram samples. The experiments were carried out at four heating rates 0.25, 0.5, 0.75, and 1 K/s. The temperature range in which the pyrolysis reaction occurs is « 300-470 oC. We applied several isoconversional methods such as Friedman, Ozawa, Flynn-Wall-Ozawa (FWO), and Kissinger-Akahira-Sunose (KAS) to estimate the apparent activation energy of thermal degradation of Poly(methyl methacrylate). Determine the activation energy from each method evaluated against the experimental data. With investigation, the FWO method shown much higher values for activation energy for PMMA polymer more than the other two methods, and the average value much higher than the Friedman and KAS methods. On the other hand, as a differential method, Friedman showed more accurate results Ea=216.65kJ/mol, and KAS method 228.61 kJ/mol. Our investigation may give a few experiences to how to more readily portray trial results with hypothetical expectations and essential data for calculating the activation energy of potential pyrolysis reactors.