A Au-SiO2 superresolution nanocomposite active nonlinear optical thin film is fabricated reproducibly by cosputtering method with the size of Au nano particles around 2 to 10 nm. Results of the Z-scan indicate that these nanocomposite Au-SiO2 films have nonlinear optical properties and enhanced transmittance at the focusing position. For a 15-nm-thick Au-SiO2 nanocomposite thin film, the transmittance can be 135% for a sample with an average grain size of around 5 nm.


CSR1, a newly characterized tumor suppressor gene located in the 8p21 region, undergoes hypermethylation of its promoter and exon 1 regions in over 30% of prostate cancers. Re‐expression of CSR1 inhibits cell growth and induces cell death, but the mechanisms of CSR1‐mediated tumor suppressor activity are not clear. In this study, a Yeast‐two hybrid screening identified proteins interacting with the C‐terminus of CSR1. The cleavage and poly‐adenylation specific factor 3 (CPSF3), an essential component for converting hnRNA to mRNA, bound with CSR1 C‐terminus with high affinity. Analysis of a series of GST‐CSR1 mutants found the binding motifs for CPSF3 located at sequence between amino acids 440–513. The interaction between CSR1 and CPSF3 induced CPSF3 translocation from nucleus to cytoplasm, resulting in nuclear inhibition of the polyadenylation activity both in vitro and in vivo. Down‐regulation of CPSF3 using siRNA induced cell death in a manner similar to those induced by CSR1 expression. CSR1 mutant unable to bind to CPSF3 did not alter CPSF3 subcellular distribution, and did not inhibit its polyadenylation activity nor induce cell death. In summary, CSR1 appears to induce cell death through a novel mechanism by hijacking a critical RNA processing enzyme.


Contents: Administration and planning in traffic engineering. Traffic studies. Traffic surveys and analysis. Parking. Traffic and environmental management. The road user, the vehicle and the road. The traffic stream and capacity. Traffic control systems. Street lighting, traffic signs and carriageway markings. Accidents and road safety.


The main focus of this research is to study the strength of concrete with ceramic waste as coarse aggregate. The sources of ceramic waste are obtained from the industrial in Malaysia. Presently, in ceramics industries the production goes as waste, which is not under going the recycle process yet. The potential of recycled ceramic waste as a substitute for coarse aggregates in concrete has been investigated. The recycle ceramic waste as aggregate was used. Concrete mixes with a 28 days characteristic strength of 20 MPa were prepared using water/cement ratio of 0.4, 0.5 and 0.7. The strength development of the concrete mixes containing recycled ceramic waste aggregates was compared to that of conventional concrete. The result show that the concrete mixes containing recycled ceramic waste aggregates achieve strength levels between 80 to 95 % compared to the conventional concrete. This indicates that the recycled ceramic waste has a potentially to be used as coarse aggregates for concrete.


The utility model relates to a fast steel cable terminal used for connecting steel cables. A cuniform terminal consists of a terminal body and a drill key. The fast steel cable terminal has the advantages that when a steel cable being not in stress state is locked, the free end of the steel cable is not needed to be depended on, and the steel cable can be directly positioned in the cuniform terminal at one side of a completely splitted cuniform terminal main body without depending on the freed end of the steel cable or using a U-shaped blocking lock for tightening the steel cable; the locking and tightening is reliable, and the usage is convenient and fast.


In order to study the effect of spontaneous combustion gangue and slag on the mechanical properties and antipermeability of concrete, the compressive strength and anti-permeability of concrete were tested. In the experiment, the mixing amount of spontaneous combustion gangue and slag, water binder ratio, sand ratio and the fineness of the spontaneous combustion gangue were regarded as influencing factors. Through orthogonal test, the optimal group was determined using workability and compressive strength of concrete as the indexes. Especially, they were compared with the compressive strength and anti-permeability of the concrete in the baseline group. The results show that the compressive strength at 28 days of the optimal group concrete is 15.9% higher than the compressive strength of reference concrete, the compressive strength at 56 days of the optimal group concrete is 5.6% higher than the compressive strength of reference concrete, its anti-permeability is about 60% higher than the anti-permeability of reference concrete.


Abstract : Gas phase displacement reactions of boron trihalides from their trimethylamine adducts show that the order of acceptor power is: BBr3 > BCl3 > BF3 > 1/2(B2H6). This order agrees with recent theoretical calculations and dipole moment, calorimetric, and infrared measurements on boron trihalide complexes with other reference bases. (Author)


We present a novel and efficient technique to extract Lagrangian coherent structures in two‐dimensional time‐dependent vector fields. We show that this can be achieved by employing bifurcation line extraction in the space‐time representation of the vector field, and generating space‐time bifurcation manifolds therefrom. To show the utility and applicability of our approach, we provide an evaluation of existing extraction techniques for Lagrangian coherent structures, and compare them to our approach.


A specific reading or writing(R/W)controller based on page-structure is proposed,which can proceed fast,consecutive or interleaving R/W operations from DVI on Synchronous Dynamic Random Access Memory(SDRAM).The design is built on FP- GA to improve the efficiency of digital video flow re-combination,and accomplishes large-scale frame's buffer and random re- combination.This design can be used in the controlling system of full-color LED display and combined liquid crystal display.


The stationary hydrodynamic equations for transonic viscous accretion discs in Kerr geometry are derived. The consistent formulation is given for the viscous angular momentum transport and the boundary conditions on the horizon of a central black hole. An expression for the thickness of the disc is obtained from the vertical Euler equation for general accretion flows with vanishing vertical velocity. Different solution topologies are identified, characterized by a sonic transition close to or far from the marginally stable orbit. A numerical method is presented that allows to integrate the structure equations of transonic accretion flows. Global polytropic solutions for the disc structure are calculated, covering each topology and a wide range of physical conditions. These solutions generally possess a sub-Keplerian angular momentum distribution and have maximum temperatures in the range $10^{11}-10^{12}$ K. Accretion discs around rotating black holes are hotter and deposit less angular momentum on the central object than accretion discs around Schwarzschild black holes.


On the basis of molecule design,copolydimethyldiallylammonium chloride-acrylic amide was obtained by the reaction in which more active monomer was supplemented in batches.The intrinsic viscosity of the polymer[ η ]=2.76 and the cation content of polymer=23.8%.Jar test proved that the polymer is especially suitable as a flocculant for the water with high turbidity.When it is used along with PFS as a coagulant for water with low turbidity,the flocculation efficiency is also satisfactory.


Introduction Cardiogoniometry (CGM) is method of 3-dimensional electrocardiographic assessment which has been previously shown to identify patients with angiographically defined, stable coronary artery disease (CAD). However, angiographic evidence of CAD, does not always correlate to physiologically significant CAD. The aim of our study was to assess the ability of CGM to detect physiologically significant coronary stenosis defined by fractional flow reserve (FFR). Methods In a tertiary cardiology centre, patients with single vessel CAD were enrolled into a prospective double blinded observational study. A baseline CGM recording was performed at rest. A second CGM recording was then performed during the FFR procedure, at the time of maximal hyperaemia. A significant CGM result was defined as an automatically calculated ischaemia score<0 and a significant FFR ratio defined as<0.8. After enrolment, CGM and FFR results were compared and markers of diagnostic performance (sensitivity, specificity, positive predictive value and negative predictive value) were calculated at rest and during maximal hyperaemia. Statistical agreement between CGM and FFR was calculated by the Kappa statistic. Results Forty patients were included (aged 61.1±11.0; 60.0% male), of which sixteen (40%) were found to have significant CAD when assessed by FFR. Markers of diagnostic performance of CGM are shown in the table. Conclusion The diagnostic performance of CGM to detect physiologically significant stable CAD is poor at rest. Although, the diagnostic performance of CGM improves substantially during maximal hyperaemia, it does not reach sufficient levels of accuracy to be used routinely in clinical practice. Abstract 103 Table 1 CGM at rest (n= 40) CGM during maximal hyperaemia (n= 40) Sensitivity 31.3% 68.8% Specificity 62.5% 54.2% Positive predictive value 35.7% 50.0% Negative predictive value 57.7% 72.2% Kappa statistic for agreement −0.06, p=0.64 0.21, p=0.15


SINCE 1956, when Wiener, Unger, Cohen and Feldman assigned the specificity anti-I to a cold antibody in a case of acquired haemolytic anaemia, antibodies of the same specificity have been found to occur very commonly in health and disease. Conversely, the antithetical antibody anti-i, first described by Marsh and Jenkins (1960), is believed to be rare. These workers tested sera from 500 normal blood donors for anti-i activity with consistently negative results, and in the course of 3 years' investigation observed anti-i on only three occasions: the first in a case of reticulum cell sarcoma, the second in a fatal case of haemolytic anaemia complicating an obscure malignant reticulosis, and the third as a haemolysin in a young woman with infectious mononucleosis. This third case prompted a study of other patients with infectious mononucleosis, and we now report another example of haemolytic anaemia due to anti-i, together with a serological survey of 85 uncomplicated cases. It vvlll be noted that Cynamolgus monkey red cells have been used in the serological investigations. Recent research into the I antigen status of various animal species reveals that the red cells of the Cynamolgus monkey are particularly rich in i antigen and are, therefore, very useful as test cells for weakly reacting i antibodies. Full details of this work will be submitted for publication later.


A measurement of the Ni-like Er 3[ital d][sub 3/2-]4[ital f][sub 5/2] transition energy is presented. The value differs from a previous prediction that was based on an interpolation of measurements of the transition in elements of nearby atomic numbers. This transition was previously thought to have an energy very near the H-like Al Ly-[alpha][sub 2] line, making the system a favorable candidate for resonant photopumping. The measured energy difference between the Er 3[ital d]-4[ital f] and Al Ly-[alpha][sub 2] transitions is 1.8[plus minus]0.3 eV or 1040 ppm indicating that the overlap is not as favorable as previously thought. The difficulties with the previous interpolation are discussed. Additional measurements of the 3[ital d][sub 3/2-]4[ital f][sub 5/2] transition energies in Ni-like Pr, Yb, and Pt are presented that achieve a precision better than 100 ppm. Together with the value for Er, these are used to derive a new interpolation with better predictive capabilities.


The thermal behavior of spin valves (SVs) and exchange-coupled films has been investigated by in situ experiments in a Lorentz microscope. In situ magnetizing combined with in situ heating experiments have been performed during observation of the magnetization reversal of SV materials. A clear demonstration of the thermal effect on the reversal of the free layer is shown as well as a decrease of the exchange-bias pinning with increasing temperature. This latter effect results in the switching of the pinned layer near the blocking temperature.


Aiming at the problem which the Universal Description,Discovery,and Integration(UDDI) service is unable to ensure the availability and efficiency of data services,this paper presents a data service selection mechanism based on Quality of Service(QoS).An evaluation model and the evaluation factors are defined,calculating method for QoS numerical quantization of data service and the service selection strategy are given.A metadata service is designed and implemented based on UDDI and Monitoring Discovery Service(MDS) technologies to support the data service selection mechanism.The results of tests show that the QoS-based data service selection mechanism can improve efficiency of data services.


In our work, a higher-dimensional shallow water wave equation, which can be reduced to the potential KdV equation, is discussed. By using the Lie symmetry analysis, all of the geometric vector fields of the equation are obtained; the symmetry reductions are also presented. Some new nonlinear wave solutions, involving differentiable arbitrary functions, expressed by Jacobi elliptic function, Weierstrass elliptic function, hyperbolic function, and trigonometric function are obtained. Our work extends pioneer results.


AfriSAR is an ESA-funded airborne P-band SAR campaign over the African tropical forests of Gabon that was carried out by ONERA (July 2015) and DLR (February 2016) in support of
 the development of the geophysical algorithms of the future BIOMASS mission. In addition, DLR will complement the P-band data set with L-band over the same sites. Both data sets will be
 constituted by properly designed multibaseline fully polarimetric acquisitions allowing the inversion of key forest vertical structure-based parameters, like e.g. forest height and high
 resolution reflectivity profiles. A first processing result of the acquired data and parameter inversion is shown in this paper at both frequencies.


Overall Equipment Effectiveness (OEE) is one of Total Productive Maintenance (TPM) application  program, which aims to determine the effectiveness of a machine. PT. X has 3 machine batching plant  where machine 1 and 2 used effectively, from the data historically known that the machines batching  plant 1 having a value greater namely 1030 minutes compared to the engine batching plant 2 that have  value 240 minutes. This research measures the OEE value of two machines Bactching Plant and then  compares the results. The value obtained is 82.71% for machine 1 and 84.83% for machine 2. This  research suggests that the performance factor is the biggest problem in the machine OEE values, because  the enterprise systems is make to order, the recommended action is to maximize the production capacity  of each machine by considering a more accurate production targets in each period.


INTRODUCTION
Although it has been used orally, the variability in its absorption and the risk of causing vomiting has lead to a push towards the intravenous use of bulsulfan. This study looks at the stability of 60 mg of busulfan, in fixed volumes of 250 mL (0.24 mg/mL) and 500 mL (0.12 mg/mL) of serum and different conservation conditions, in a new plastic pack made from polyolefin/polyamide laminates.

MATERIAL AND METHODS
High-efficiency liquid chromatography with ultraviolet detection was used to determine the concentration of busulfan derivate with sodium diethyldithiocarbamatetrihydrate. Stability was assessed for both concentrations; refrigerated and at room temperature, using the t(90) of each sample.

RESULTS
The percentage of the remaining busulfan concentration at 24 h was always less than 90%. At 25 degrees C and 0.24 mg/mL concentration, the t90 was 8.4 h; at 4 degrees C and a concentration of 0.24 mg/mL it was 16.7 h; at 25 degrees C and a concentration of 0.12 mg/mL it was 12 h and at 4 degrees C and a concentration of 0.12 mg/mL it was 11.5 h.

CONCLUSIONS
This study show that busulfan in a concentration of 0.24 mg/mL in serum is stable in the bags tested during a refrigerated storage period of 12 h plus two additional hours of administration of the drug.


A high electric field technique was developed to fabricate buried optical waveguide modulator on K9 optical glass. The 80V voltage was applied on the glass to accelerate the field-driven ion exchange process by expeditiously replacing host sodium ions in the glass with silver ions. As a result, the optical loss for optical waveguide modulator was measured using the edge coupling technique with a 0.6328μm He-Ne laser. Loss of 0.20 dB/cm was obtained for channel waveguides of 25μm in depth, relatively low for waveguides of such depth at red wavelength.


The number of reported natural and human-made disasters continues to rise worldwide. Nurses comprise the highest percent of health and medical workforce. Nurses must understand the national disaster management cycle. The present study was aimed to examine nurses' knowledge, attitudes, practices and familiarity regarding disaster and emergency preparedness-Saudi Arabia. Cross-sectional descriptive study was conducted using five tools to obtain data from 252 two registered batches of bridging nurses students. Five tools were demonstrated to collect data about demographic data, questionnaire for knowledge, attitude and practice to measure disaster preparedness and emergency preparedness information questionnaire to measure nurses' familiarity. The study findings revealed that the mean age score was 26.36±1.82 and for the knowledge level was 21.2 ± 6.0. A highly significant difference was found for attitude and practice regarding disaster preparedness as well familiarity concerned emergency preparedness P≤.000. Based on the present study results; lacking of knowledge and practices with acceptable level of attitude regarding disaster preparedness and neutral familiarity with emergency preparedness were concluded. Thus an integration of clearly titled theory and practice teaching courses about disaster and emergency preparedness into nursing curricula are crucial needed and provided in respect to their learning/training preferences. Further, follow up research are necessary for maximizing nursing education and nursing quality in these critical areas applied to healthcare and community setting.


Daptomycin is a lipopeptide antibiotic that contains 13 amino acids and an N-terminally attached fatty acyl residue. The antibiotic kills Gram-positive bacteria by membrane depolarization. It has long been assumed that the mode of action of daptomycin involves the formation of oligomers on the bacterial cell membrane; fluorescence energy transfer (FRET) is used between native daptomycin and an NBD-labeled daptomycin derivative to demonstrate that the antibiotic indeed forms oligomers on bacterial cell membranes. In a liposome model, oligomer formation depends on calcium and on phosphatidylglycerol (PG).Furthermore, membrane permeabilization is selective, and electron microscopy of bacterial membranes exposed to daptomycin has revealed no discontinuities or accretions of electron density.


Two Attempts for Automatic Wheelchair Control via Electroencephalogram Kazuo TANAKA*,Horoshi OHTAKE* and Hirokazu SAKAMOTO* This paper presents two attempts for automatic wheelchair control via electroencephalogram( EEG). One is an attempt for increasing successful rate of the EEGbased control without training tasks. The other is an attempt for reducing the number of electrodes without decreasing successful rate of the EEGbased control. Our experimental results with 10 subjects illustrate the viability of both the attempts.


Despite the fact that the food and processing industry occupies a leading position in the industrial structure of Russia, there are several problems associated with the high import dependence of the country on certain types of agricultural products and foodstuffs. In this connection, the priorities in the area of food production is the introduction of modern science and technology, and the use of resource-saving technologies and equipment. The brewing industry is no exception in solving these problems. In this industry there are several problems associated with the lack of quality grain. Traditional crops for the production of malt and beer is barley. In the technology of production of malt longest and important stage is the process of germination, which will be held successfully, provided that the quality of barley grain is satisfactory. Since grain quality does not satisfy the requirements of malting and its subsequent use in brewing, concerning production cycle requires sound processing and purposeful grain before malting. Modern research and development can not only improve the process, but also to improve it. The proposed processing method allows us to improve the quality of malt, and hence the quality of the final product – beer using barley and nonstandard simultaneously reducing the cost of beer production. A peculiarity of the method consists in that after treatment in a microwave field is performed by sorting classes barley, barley after which sorted or sent on for further steeping and malting and brewing of beer, or re-treated in a microwave field with a predetermined exposure parameters.


Results—We found that as many sows farrowed within a 48hour period following injection into the vaginal mucosa of 25% of the recommended dose as farrowed following intramuscular (IM) injection of the full dose. Experiment 2 confirmed the efficacy of the 25% dose when injected vaginally. However, when sows were injected perianally with cloprostenol, the 50% dose proved relatively effective, but fewer farrowed within the 48-hour period when a 25% dose was used.


The viability of metaphysics as a field of knowledge has been challenged time and again. But in spite of the continuing tendency to dismiss metaphysics, there has been considerable progress in this field in the 20thand 21st-centuries. One of the newest – though, in a sense, also oldest – frontiers of metaphysics is the grounding project. In this paper I raise a methodological challenge to the new grounding project and propose a constructive solution. Both the challenge and its solution apply to metaphysics in general, but grounding theory puts the challenge in an especially sharp focus. The solution consists of a new methodology, holistic grounding or holistic metaphysics. This methodology is modeled after a recent epistemic methodology, foundational holism, that enables us to pursue the foundational project of epistemology without being hampered by the problems associated with foundationalism. The viability ofmetaphysics as a field of knowledge has been challenged time and again. Some have challenged "traditional" metaphysics, or what was considered to be "traditional metaphysics" at the time; others have challenged metaphysics in general. Kant falls under the former category, Carnap under the latter. Kant likened Plato's metaphysics to a "light dove" who, "cleaving the air in her free flight, and feeling its resistance,might imagine that her1flightwouldbe still easier in empty space". "Plato", Kant continues, "ventured out beyond [the world of the senses] on the wings of the ideas, in the empty space of the pure understanding. Hedidnot observe thatwith all his efforts hemadenoadvance–meetingno resistance thatmight, as itwere, serve as a support uponwhichhe could take a stand, to which he could apply his powers, and so set his understanding in motion." (Kant (1781/87), A5/B8-9). Carnap rejected metaphysics altogether: "the so-called statements of metaphysics aremeaningless"; "metaphysics in its entirety consists of ... pseudo-statements" (Carnap (1932), p. 61). 1 I follow Kant's original text by using "her" ("ihr") for the dove in this place, where Kemp Smith uses "its", although in thefirst part of the sentenceheuses "her". Guyer andWooduse "it" in both places. Kant's original formulation of the sentence is: "Die lechte Taube, indemsie im freien Fluge die Luft teilt, deren Widerstand sie fühlt, könnte die Vorstellung fassen, daß es ihr im luftleeren Raum noch viel besser gelingen werde." https://doi.org/10.1515/9783110664812-004 Authenticated | email@example.com author's copy Download Date | 12/5/19 6:08 AM


In A Confession , a memoir of his philosophical midlife crisis, Tolstoy recounts falling into despair after coming to believe that his life, and for that matter all human life, is meaningless and absurd. Although Tolstoy's account of the origin and phenomenology of his crisis is widely regarded as illuminating, his response to the crisis, namely, embracing a religious tradition that he had previously dismissed as "irrational," "incomprehen-sible," and "mingled with falsehood" seems unpromis-ing, at best. Nevertheless, I argue, Tolstoy's account of his response makes a valuable contribution to contemporary thought about the meaning and absurdity of life. I begin by drawing on classic discussions in the philosophical literature, and on Tolstoy's memoir, in order to characterize the problem of meaning and the problem of the absurd, and to clarify the relation between these problems. I then draw on Tolstoy's account of his response to his crisis in order to characterize a form of faith in our deepest values. I argue that such faith supplies one important part of the story concerning how we might respond to the problem of the absurd - a part that has been overlooked by more recent discussions of these issues.


Introduction.- Static Focal Points Dynamic Focal Points Outline Static Focal Points in Framed Strategic Games.- Introduction Examples Harsanyi and Selten's Symmetry Invariance Requirement Rationalizing Static Focal Points Framed Strategic Games (FSGs) Focal Points in FSG Representations of VUMGs Weak Isomorphisms of Extensive Games.- Introduction Finite Extensive Games with Perfect Recall Invarance with Respect to Weak Isomorphisms Strong Isomorphisms of Extensive Games Traditional Extensive Representations of Strategic Games Conclusion Dynamic Focal Points in Framed Extensive Games.- Introduction Examples Modelling Dynamic Focal Points Framed Extensive Games (FEGs) Modelling Dynamic Focal Points by FEGs Conclusion.-Static Focal Points in Framed Strategic Games Weak Isomorphisms of Extensive Games Dynamic Focal Points in Framed Extensive Games Perspective List of Symbols and Abbreviations List of Figures Bibliography


Data Insights offers multi-disciplinary perspectives and useful information about how visualizations can open your eyes to data. This thought-provoking book takes a conversational approach to presenting an overview of the subject, while also focusing on key details. It highlights the ideas and work of a variety of people who are actively contributing to this still emerging field. Case studies from business analytics, healthcare, games, security, and network monitoring, among others, portray what is going on in data visualization today. A diverse blend of original illustrations and real-world examples, both classical and cutting-edge, help fill in the picture.

This book provides an approachable overview of important aspects of data visualization, and...

Demonstrates, with a variety of case studies, how visualizations can foster a clearer and more comprehensive understanding of data

Answers the question, "How can data visualization help me?" with discussions of how it fits into a wide array of purposes and situations

Makes the case that data visualization is not just about technology; it also involves a deeply human process

Demonstrates, with a variety of case studies, how visualizations can foster a clearer and more comprehensive understanding of data

Answers the question, "How can data visualization help me?" with discussions of how it fits into a wide array of purposes and situations

Makes the case that data visualization is not just about technology; it also involves a deeply human process

Table of Contents

Chapter 1 From Terabytes to Insights Chapter 2 A More Beautiful Question Chapter 3 Winning Combinations: Working with the Ingredients of Data Visualization Chapter 4 Pathways, Purposes, and Points of View Chapter 5: Views You Can Use Chapter 6 Thinking...Machines Chapter 7 Hindsight, Foresight, and Insight


The emergency management of a patient presenting in respiratory failure due to critical tracheal stenosis caused by an intratracheal foreign body is described. The use of an extracorporeal oxygenator in the anaesthetic management of the patient is highlighted.


While the quest for the best possible arthroplasty materials and designs continues, many orthopaedic surgeons and their patients will have to deal with the consequences of component wear. This month's "Case Connections" focuses on serious or unusual complications related to wear in hip and knee prostheses.

In the February 11, 2015 edition of JBJS Case Connector, Knudsen et al. reported on the case of a cobalt-chrome femoral head completely wearing through both the polyethylene and titanium materials of the acetabular component. The patient, a fifty-one-year-old man, presented with eight months of worsening left hip pain thirteen years after undergoing a left total hip arthroplasty (THA) to treat osteoarthritis.

The physical exam revealed severe hip pain and a 0.5-inch leg-length discrepancy. Radiographs showed a well-seated femoral stem but complete penetration of the femoral head through the polyethylene liner and acetabular cup, leaving the metal head in direct contact with the roof of the osseous acetabulum.

During revision THA, surgeons found black metallosis debris in the hip capsule (Fig. 1) and the remains of the liner dangling around the femoral neck like a collar. Surgeons also encountered substantial osteolysis in the posterior part of the acetabulum, and during revision they used cancellous allograft to repair the acetabular defect. Laboratory analysis of the explanted cup led the authors to suggest that a mismatch in hardness between the cobalt-chrome head and the much softer titanium shell added an unusual complication to the primary failure of the polyethylene liner. Although titanium is softer than cobalt-chrome, it has better osseointegration than cobalt-chrome alloys and is thought to facilitate better fixation. Consequently, minimizing polyethylene wear should be a more …


Libraries use Alma for a variety of workflows. Some workflows are complex and lengthy, and are repeated often. Some are used too infrequently to remember the best way to do them in Alma. Some workflows just require the data in different formats. In this talk, I will describe my system for expressing workflows as a sequence of API calls, making them easy to use, reproduce, and modify.

My open-source library, Grima, provides web and command line interfaces for performing many common tasks in Alma. Some of these include: formatting records for printing, displaying records in a hierarchy, normalizing records, adding many items to a serial, creating bib-holding-item chains with common settings, and creating "boundwiths". Grima's library (written in PHP) is general enough that new custom workflows can be quickly written for new projects.


Aim

Terrestrial invertebrates comprise a large proportion of alien species world-wide, yet a quantitative global synthesis of their effects on native species and ecosystems has not been explored. We conducted a meta-analysis to examine the ecological impacts of terrestrial invertebrate invaders and to test how impacts are modulated by the invader's trophic position, habitat attributes (i.e. insularity and disturbance) and the study methodology (observational versus experimental).

Location

Global.

Methods

We investigated the effects of terrestrial invertebrate invaders on populations, communities and ecosystems by conducting a random effects meta-analysis using 112 articles reporting data from 710 field and laboratory studies. The analysis included 16 insect, 11 earthworm, 7 slug and 1 nematode invaders.

Results

On average, across invaders, the presence of invaders reduced plant fitness (52%), animal diversity (33%) and animal abundance (29%). Leaf litter decomposition was 41% higher in the presence of invaders, while other ecosystem-level variables such as nutrient cycling were not affected in a consistent direction. Invasive predators and detritivores decreased animal abundance, whereas herbivores and omnivores had limited impacts. Single invaders increased soil nitrogen pools while multiple species did not. Insularity and disturbance did not affect the magnitude of the impacts significantly, mainly because there was a large variation among studies.

Main conclusions

Overall, our study indicates that terrestrial invertebrate invaders have significant consistent effects on populations, communities and ecosystems, with islands and disturbed sites not being more prone to impacts. However, effects vary considerably depending on the type of impact being examined and the trophic position of the invader. There is no evidence that invaders cause larger impacts when multiple species of invaders, rather than single invaders, are involved.


Sovereign debt crises are not a new phenomenon. Thus, history offers useful insights into the complex nature of sovereign debts and ways of addressing debt crises. This chapter explores sovereign debt problems and the responses to such problems in historical perspective. The chapter discusses historical episodes of sovereign debt defaults, how such defaults were settled and the impact of sovereign debt defaults on international relations. It also deals with the issues of odious debts, colonial 'sovereign' debts, reckless lending and borrowing and fairness to repay.


If f(z) satisfies (1) but meets the weaker restriction that/(z) is regular for (R(z) ̂ 0, we shall say that it belongs to K*(a, c). A set A is said to be a set of uniqueness for a class K of functions provided that the only function/(z) in K such that/(a) =0 for each a in A is the null function /(z)=0. Finally, we say that A has blocks of ratio <p if there is an increasing sequence [w*]*=o,i,2,--such that if nk^n^(pnk, then n is contained in A. (HA has blocks of ratio <p for each positive <p, we say that A has blocks of ratio «>.) It is our main purpose to prove the following result.


The accuracy of photoelastic modulated optical fibre sensors suffer from temperature-dependency. Two designs have been developed, aimed at eliminating this deficiency. The evolution of the designs is explained and preliminary results reported.


A social interaction perspective is presented in order to conceptualise the processes of service provision and representation and the 'consumer' evaluations thereof. The role of kinesic behaviour is then explored and an experiment demonstrating these effects on service representation evaluation is reported. High levels of gaze and body movement are found to influence 'consumers' to act as proposed as well as to evaluate the presenter of the proposal more highly. In addition, kinesic treatments appear to result in better evaluations of the service which is the subject of the proposal. Recommendations for kinesic training and recruitment criteria are presented.


In 2017, the Liberal government released Bill C-59, which was its update to the national security legislation that was introduced by the previous government via Bill C-51. Bill C-59's goal was to address the criticisms of its predecessor, including the new "kinetic" powers granted to the Canadian Security and Intelligence Service (CSIS) to actively disrupt threats to the security of Canada. While Bill C-59 made some improvements to ensure that CSIS's new powers are exercised in accordance with the Charter, there are still deficiencies to be addressed. This article reviews the changes brought in with Bill C-59, examines how those amendments may not avoid constitutional challenge, and outlines what a section 1 Oakes justification may look like. Ultimately, to address the Charter implications of the new legislation, further changes are required, including the use of court-appointed special advocates to ensure an adversarial system and further oversight of CSIS's new, disruptive authority.


Viewed from the native place,most literary authors of the Eastern Wei Dynasty derived from Shandong district.Secondly was ethnic Chinese minority Gentry.The third was Guanzhong gentry,local gentry and non-local gentry,and finally was Southern gentry.Because political situation had changed greatly,the geographical distribution of literary authors appeared imbalance in the Eastern Wei Dynasty.Eastern Wei Dynasty was the period of focusing the outcome of the literature in the late Northern Wei Dynasty,and was the period of digesting the Song Dynasty and Qi Dynasty literature factors.This created the preconditions for literature of the Northern Qi Dynasty reaching the peak of the Northern Dynasties literature.Therefore,Eastern Wei Dynasty played the role of a connecting link between the preceding in the latter part of the Northern Dynasties.


An increasing number of chemicals were found in drinking water recent years which gradually produce the adverse effects on human health and the environment. Therefore, safety evaluation plays an important role in the process. The advance in safety evaluation of drinking water and products for use in contact with water(their lixivium), introducing their principles, procedures and practical applications, were systematically reviewed in this paper. Comparison analysis was made to indicate the advantages and problems of the existing methods, to suggest a broad-spectrum, reliable, sensitive and applicable method for safety evaluation of drinking water in the future.


focus on the economic person during efforts toward greater socioeconomic balance. Undeniably, each literary contribution addresses a significant component of the social equity debate. It is left to be seen, however, whether these considerations will take the forefront in legislative motions for wealth creation, wealth sharing, and increased opportunities for individual economic advancement. At the level of theory, the importance of individual preferences, choices, and values is crucial for an understanding of the effects of individual actions. The extent to which it is, and can be, incorporated into wider socioeconomic planning processes is questionable though. It may be more economical for governments to generalize when determining what is in the greater public interest, instead of focusing on the minutiae behind the rationale governing human behaviors. This perspective lends itself to the interpretation of author contributions on personalist economics. The foundational thinking for this branch of economic thought is noble and unreservedly selfless, but unfortunately, it bears semblance to the unrealistic, as it has not traversed the boundary between theory and real-world socioeconomics. The suggested need for greater government involvement through workable public policy mechanisms and human capital investment is a positive step that augurs well for increased social equity and greater social well-being. Whether governments are prepared to assume a more proactive role in this respect, however, is determined not just by social wants, but also by the workings of globalization. Social economics, as evidenced by the publications reviewed, has come a long way, and will continue to add important elements to the wider debate on what is required to sustain social well-being in the long term.


This paper describes a thermal balance and x‐ray diffraction study of the reaction of lithium with water vapor. Water was carried at partial pressures of up to 12.6 mm Hg in oxygen and argon gases, and runs were conducted between 20° and 45°C. The reaction was found to proceed in three distinct successive stages: (a) the formation at constant rate of a lithium hydroxide () film believed to be coherent with the underlying lithium metal lattice; (b) the localized nucleation and growth by spreading of lithium hydroxide monohydrate () at the outer surfaces of the hydroxide; and (c) the simultaneous formation and hydration of the hydroxide at constant rate, culminating in complete conversion of the metal to the hydroxide monohydrate.


Abstract The present study emphasizes the reinforcement of rigid polyurethane foam (RPUF) by the addition of glass fibers (GFs) for diverse engineering applications. In contrast to the conventional RPUF, the foam developed in this case is castor oil based. The developed reinforced foam was tested for its mechanical properties such as hardness, tensile, flexural and compressive strength and for its morphology. Mechanical properties of the resulted reinforced RPUF were found to be improved with addition of the GF content. The foam density was also observed to be increased with the insertion of GF. The SEM results clearly indicated the decreased cell size in the reinforced RPUF.


Objective To design a non-invasive monitoring system of Hypertensive Disorder of Pregnancy based on UMPC to help medical staff to predict the risk of suffering from Hypertensive Disorder of Pregnancy and to reduce its incidence. Methods A miniature device was designed to collect pulse wave, through it, the radial artery pulse wave data of the pregnant woman could be got, then, the wave data was analyzed and calculated by the UMPC, and the cardiovascular hemodynamic parameters were sought out, after that, the risk of suffering from Hypertensive Disorder of Pregnancy could be predicted through the parameters. Results Combined with non-invasive cardiovascular hemodynamic detection theory and signal processing technology, Hypertensive Disorder of Pregnancy could be predicted by the monitoring system which was designed in this topic. Conclusion The clinical experiment has confirmed that it is possible and effective to predict Hypertensive Disorder of Pregnancy by using the radial artery pulse wave, and because of its portability and convenience, the non-invasive monitoring system of Hypertensive Disorder of Pregnancy is applied not only to large medical institutions such as hospitals, but also to the home health care.


Recent literature highlights the need to focus on the impact of intrusive symptoms as a possible risk factor for the development and maintenance of PTSD. Cognitive and sleep models also contribute to the further understanding of intrusive symptoms. Further emotion work emphasizes that disgust is an emotion closely associated with the emergence of posttraumatic stress symptomology following traumatic events.

 This study utilized a film eliciting disgust to examine the effects of acute sleep deprivation on the intensity of intrusive symptoms and emotion reactivity. Forty-nine college students were randomly assigned to sleep as usual or an acute sleep deprivation after watching a disturbing film. It was hypothesized that, relative to the control group, participants who were acutely sleep deprived would report higher frequency of intrusive symptoms and higher negative valence.

 Findings were partially consistent with hypotheses. There were no group or interaction effects on intrusive symptoms, although participants across both groups reported significant decreases in negative valence and intrusive symptoms across the study (F(1, 47) = 10.30, p < 0.01). There was a significant interaction effect between sleep group and self-reported negative valence, where individuals in the sleep deprived group reported significantly higher valence than individuals in the control group, despite significant decreases in negative valence over time (F(1, 48) = 7.869, p < 0.01).

 Possible mechanisms that may contribute to the significant difference in valence may be due to higher order emotion regulation strategies that are compromised due to sleep loss. However, the significant decreases in negative valence and intrusive symptoms over time may be due to methodological factors or the type of sleep manipulation. Further work can address these challenges by using a larger sample size or examining the effects of chronic, partial sleep deprivation.
 Support (if any):


In this work, we investigated the technological features of promising technologies for laser welding and friction stir welding of high-strength aluminum-lithium alloy V-1469. The modes of laser welding and friction stir welding have been carried out. In this article, we showed the perspective welding methods provide high values of ductility and impact toughness, while the strength of welded joints is not less than 0,8 of the strength of the base material and values of low cycle fatigue is not less than 110•103 cycles. The results allows to propose laser welding and friction stir welding processes as an alternative to riveted joint for aluminum-lithium alloy V-1469 as applied to the elements of the fuselage.


OBJECTIVE
To determine whether 2.0 mm cancellous screws are superior to 2.0 mm cortical screws when inserted into cancellous and bicortical bone.

STUDY DESIGN
Biomechanical study.

METHODS
The 2.0 mm cancellous screws and 2.0 mm cortical screws were inserted according to the recommended guidelines in synthetic cancellous and bicortical blocks. Fifteen screw-block constructs per group were tested to failure in axial pullout. Axial pullout strength and yield strength were calculated. Data were analyzed using a one-way ANOVA.

RESULTS
The 2.0 mm cortical screws achieved lower axial pullout strength than 2.0 mm cancellous screws in cancellous blocks. The 2.0 mm cortical screws achieved greater pullout strength than 2.0 mm cancellous screws in bicortical blocks.

CONCLUSION
The 2.0 mm cancellous screws may offer a biomechanical advantage in bone with thin cortices (<1 mm thick), whereas 2.0 mm cortical screws may be preferred in cortical bone with cortices measuring at least 1 mm in thickness.


During the urbanization process, when facing complex requirements of city development, ever-growing urban data, rapid development of planning business and increasing planning complexity, a scalable, extensible urban planning management information system is needed urgently. PM2006 is such a system that can deal with these problems. In response to the status and problems in urban planning, the scalability and extensibility of PM2006 are introduced which can be seen as business-oriented workflow extensibility, scalability of DLL-based architecture, flexibility on platforms of GIS and database, scalability of data updating and maintenance and so on. It is verified that PM2006 system has good extensibility and scalability which can meet the requirements of all levels of administrative divisions and can adapt to ever-growing changes in urban planning business. At the end of this paper, the application of PM2006 in Urban Planning Bureau of Suzhou city is described.


• Volume 117 • Number 3 www.anesthesia-analgesia.org 583 CASE DESCRIPTION A 73-year-old non-obese man with a history of hypertension, coronary artery disease, and hyperlipidemia presented to our institution for off-pump coronary artery bypass grafting. Consent for publication of this case has been obtained from the patient. After induction of general anesthesia, a comprehensive transesophageal echocardiography (TEE) examination was performed. The midesophageal 4-chamber (ME 4C) view demonstrated an extrusion of the myocardial wall at the base of the anterior tricuspid valve (TV) annulus by 2-dimensional (2-D) (Video 1, see Supplemental Digital Content 1, http://links.lww.com/AA/A566) and 3-D (Fig. 1; Video 1, http://links.lww.com/AA/A566) imaging. The mobile, well-circumscribed, homogenous mass was not pedunculated, lacked cystic characteristics, and measured 1.8 × 2.2 cm. The modified bicaval view (Fig. 2; Video 2, see Supplemental Digital Content 2, http://links.lww.com/ AA/A567) confirmed that the anterior leaflet was anchored to the mass. The mass was noted in close proximity to the right atrial appendage but did not involve the crista terminalis. The transgastric (TG) short-axis view (Video 3, see Supplemental Digital Content 3, http://links.lww.com/ AA/A568) further established the relationship of the bright echogenic mass and the anterior leaflet of the TV. Threedimensional TEE imaging in the ME 4C view provided a unique perspective of the valvular geometry that helped elucidate how the mass might affect TV structure and function. Three-dimensional imaging revealed normal TV leaflets and annulus with unhindered opening of the TV leaflets in diastole (Video 1, see Supplemental Digital Content 1, http://links.lww.com/AA/A566). Color-flow Doppler analysis of the TV demonstrated mild tricuspid regurgitation (Video 3, see Supplemental Digital Content 3, http:// links.lww.com/AA/A568). Continuous-wave Doppler was not obtained, but tricuspid stenosis was excluded on the basis that there was no thickening or shortening of the valve leaflets, there was a low-velocity laminar flow, and there was a lack of turbulence or aliasing by color-flow Doppler across the TV. After discussion with the surgical team, the decision was made not to excise the incidentally identified lesion


This is a compilation of ideas for all brides-to-be from one of Southern USA's foremost experts on entertaining. Weddings are more in vogue than ever, and in no other region of the United States are they celebrated with greater panache, ingenuity, and tradition than in the American South. On the pages of this information-packed volume, author Beverly Church explores all the elements that make Southern weddings so special. She begins by tracing the romantic history of Southern weddings from Colonial times to the present and suggests ways to incorporate time-honoured traditions into today's wedding. Each successive chapter is devoted to an in-depth discussion of one essential aspect of wedding preparation: the engagement, the dress, invitations and parties, the gifts, the flowers, the ceremony, the reception and the food. We are invited to a broad array of weddings all over the South, from an intimate chapel ceremony in the mountains of North Carolina to a lavish social event at a Virginia plantation, to a no-holds-barred bash in the Texas Hill Country. Illustrated with full colour photographs of weddings in such diverse locales as Washington DC, New Orleans, and Atlanta, as well as with nostalgic vintage photographs, "Weddings Southern Style" is a useful guide, full of ideas for brides to be everywhere.


This paper presents a method that provides necessary documentation to evaluate an entire facility before and after refurbishement, as well as assess future nedds for modifications, repairs and equipment purchase.


Antiestrogenicity of nonsteroidal compounds was studied by showing their antifertility effects on the uterus cervix and vagina of ovariectomized estrogen-treated rats. The compounds 2-phenyl-3-para(beta-pyrrolidinoethoxy)-phenyl-6-methoxy-benzofuran hydrochloride 2-phenyl-3-para-(beta-pyrrolidinoethoxy)phenylnaphtho-(21-b) furan 34-trans-22-dimethyl-3 -phenyl-4-(para-(beta-pyrrolidinoethoxy) and 3-chloro-23-diphenyl propiophenone were administered intraperitoneally for 5 consecutive days in doses of 4 2 .25 and .5 mg/kg/rat/day respectively. The rats were sacrificed 24 hours after the last injection. The third compound exhibited antiestrogenicity on all 3 organs; the first compound showed this property only on the uterus; the other 2 exerted no antiestrogenic action on any of the target sites. The difficulty in drawing a clear-cut conclusions about the antiestrogenicity of these compounds was emphasized.


A type of horizontal double-channel francis hydraulic turbine was designed based on the working principle of vane hydraulic machinery.In order to optimize its structure,ensure the performances and maximize the efficiency of water-power recovery,a three-dimentional tubulence numerical simulation was performed for the inner flow field of the turbine with and without guide vanes under clear water medium,based on the Navier-Stokes equation and the standard two-equation turbulent model of κ-e,using the body-fitted coordinates,unstructured-tetrahedron grid and SIMPLEC algorithm.The research indicates that compared to the turbines without guide vanes,the velocity circulation and pressure distribution in the runner's blade inlet,the velocity and pressure distribution in the blade surface and the internal flow state of the draft tube are more uniformity when the guide vanes exist,which increases the energy conversion index of the runner and provides a theoretical and practical reference for the further researches on the structure of energy recovery turbines.


AbstractGassy soils are a special case of unsaturated soils, for which the gas phase exists in the form of occluded bubbles of a size that allows the bubbles to fit within the void spaces without d...


Safe and economic methane gas production, as well as the replacement of methane while sequestering carbon in natural hydrate deposits, requires enhanced geomechanical understanding of the strength and volume responses of hydrate‐bearing sediments during shear. This study employs a custom‐made apparatus to investigate the mechanical and volumetric behaviors of carbon dioxide hydrate‐bearing sediments subjected to direct shear. The results show that both peak and residual strengths increase with increased hydrate saturation and vertical stress. Hydrate contributes mainly the cohesion and dilatancy constraint to the peak strength of hydrate‐bearing sediments. The postpeak strength reduction is more evident and brittle in specimens with higher hydrate saturation and under lower stress. Significant strength reduction after shear failure is expected in silty sediments with high hydrate saturation Sh ≥ 0.65. Hydrate contribution to the residual strength is mainly by increasing cohesion at low hydrate saturation and friction at high hydrate saturation. Stress state and hydrate saturation are dominating both the stiffness and the strength of hydrate‐bearing sediments; thus, a wave velocity‐based peak strength prediction model is proposed and validated, which allows for precise estimation of the shear strength of hydrate‐bearing sediments through acoustic logging data. This method is advantageous to geomechanical simulators, particularly when the experimental strength data of natural samples are not available.


Abstract Herein, we describe an efficient and rapid protocol for the synthesis of hitherto unreported 5-(benzothiazol-2-ylmethyl)-4-aryl-1,2,4-triazole-3-thiones by a one-pot condensation of 2-(benzothiazole-2-yl)acetohydrazide and aryl isothiocyanate in the presence of a base in the ionic liquid [bmim]Br. Among the eleven newly synthesized hybrid benzothiazolyl-triazole analogues, 5-(benzothiazol-2-ylmethyl)-4-(4-chlorophenyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione (3d) displayed promising antifungal activity with MIC values of 12.5 and 0.39 μg/mL against the Aspergillus fumigatus and Candida albicans, respectively. Molecular docking studies employing CYP51 was also carried out to evaluate the binding mode of the most potent triazole derivative.


In response to a request from the north east district of Department of Main Roads (DMR) Tasmania, the Australian Road Research Board in October 1976, conducted extensive investigations on sections of the tasman highway that were seriously distressed due to heavy log haulage traffic. The object of the work was to develop pavement surface deflection and pavement thickness - subgrade CBR criteria for reconstruction of failed sections. A follow up investigation of pavement surface deflection and deflection bowls using the benkelman beam was carried out in October 1977 on some of the previously investigated sections that were scheduled to be reconstructed in early 1978 with the objective of determining variation in deflection with time and obtaining more information on the strength of a granitic gravel pavement material. In this report the subsequent investigation is discussed and an assessment is made of two reconstruction proposals suggested by the DMR, Tasmania, which involve widening of road and then strengthening with bituminous concrete by two different methods.


A 34-year-old male presented to our emergency department with a penile mass which had appeared 5 years previous, but which only recently had produced intolerable penile pain, dysuria. and fever. A pelvic computed tomographic scan showed a homogenous hypodense mass lesion measuring 10×8×8cm over the pubic region. A malignant penile tumor was suspected, and a total penectomy with urethroplasty was performed. Histological examination of the specimen revealed it to have typical features of a Buschke-Loewenstein tumor. A small recurrent condyloma over the scrotal skin was found 2 weeks later and was successfully treated with electrocauterization. At the time of this writing, 18 months after the operation, there had been no further tumor recurrence.


The article deals with the formation of the structure of hoists for lifting cranes in order to prevent the development of cracks by forming the structure of steel 20 by treatment in the conditions of self-propagating high-temperature synthesis (SHS) to obtain fine-grained ferrite-perlite structure. The conducted researches allow to form a rational structure of steel to exclude the development of cracks in dangerous sections of lifting hooks of hoisting and transport mechanisms working in the shops of metallurgical production. The method of structure control after SHS is developed taking into account the influence of different diameters of hooks.


The high temperature and high pressure supersonic jet is one of the key problems in the design of solid rocket motors. To reduce the jet temperature and noise, cooling water is typically injected into the exhaust plume. Numerical simulations for the gas-liquid multiphase flow field with mixture multiphase model were developed and a series of experiments were carried out. By introducing the energy source terms caused by the vaporization of liquid water into the energy equation, a coupling solution was developed to calculate the multiphase flow field. The temperature data predictions agreed well with the experimental results. When water was injected into the plume, the high temperature core region area was reduced, and the temperature on the head face was much lower than that without water. The relationship between the reduction of temperature on the bottom plate and the momentum ratio is developed, which can be used to predict the cooling effect of water injection in many cases.


.............................................................................................................................. ii Dedication ......................................................................................................................... iii Acknowledgments............................................................................................................. iv Vita .......................................................................................................................................v List of Tables .................................................................................................................... vii List of Figures .................................................................................................................. viii Chapter 1: Introduction ........................................................................................................1 Chapter 2: Study 1 .............................................................................................................12 Chapter 3: Study 2 .............................................................................................................17 Chapter 4: Study 3 .............................................................................................................22 Chapter 5: General Discussion ...........................................................................................32 References ..........................................................................................................................38 Appendix A: Tables of Results ..........................................................................................44 Appendix B: Graphs of Results .........................................................................................48


Continuous infusion of epidural anesthesia was first used for postoperative analgesia,and gradually applied to adult surgical anesthesia,now continuous epidural lidocaine anesthesia has become one of the common methods used in clinical anesthesia.This paper summarizes the application status of continuous epidural lidocaine anesthesia.


The key to reducing processing costs, improving product yield, and optimizing material properties in composite materials fabrication is the use of intelligent process control (IPC). IPC completes the processing feedback loop by obtaining in situ sensor information, analyzing this information to make processing decisions, and then applying control parameters to the process in real-time. Information for IPC sensors must go beyond the traditional measurements of temperature and pressure, and include data such as resin viscocity, resin position within the mold, resin gelation-point, degree-of-cure of the composite, types of polymerization reactions taking place, presence of moisture, and the like. Two light-based sensors are described which have been utilized to obtain this information: (1) a novel infrared (IR) fiber-optic sensor, developed at BIRL, and (2) a commercially available index of refraction sensor. The information provided by these sensors relates directly to material performance. This paper also describes how neural networks were used to interpret the data collected by the IR fiber-optic sensor.


In this paper, we present a novel methodology to improve gaming experiences by automatically adjusting the game difficulty throughout the game play using a Profile-based Adaptive Difficulty System (PADS). We utilize a player's gaming experience and objective to create a player profile. Utilizing this profile and a performance-based algorithm, the PADS customizes the game's difficulty levels to accommodate each individual. Our experimental results successfully demonstrate improvements in both perceptual and actual gaming experiences. With our approach, traditional program-centered video games can be transformed to provide individualized, player-centered gaming experiences.


) onto theaffected skin and sent their patients intobright sunlight. In 1903, as every brightyoung dermatology fellow knows (orshould know), Niels Finsen was awardedthe Nobel Prize in Medicine in 'recogni-tion of his contribution to the treatmentof diseases with concentrated light radi-ation'. Finsen used sunlight, and/or arti-ficial UV radiation to treat the cutane-ous manifestations of tuberculosisinfection. In the award presentationspeech, KAH Morner, Rector of theRoyal Caroline Institute, (Stockholm,Sweden) pointed out, "…the results areparticularly satisfactory and are far supe-rior to those obtained previously in thebattle against this disease"


A 13-month-old girl developed a superficial, multinodular, blue-grey upper eyelid mass shortly after birth. This was clinically suspected to be a lymphangioma. Ultrasound biomicroscopy revealed a subcutaneous mass with a multicystic internal structure and fluid levels consistent with lymphangioma. Follow-up ultrasound biomicroscopy 2 years later showed stable findings.


Historical accounts describing the maladies of prominent persons seem to beg for a diagnostic opinion from every physician who stumbles across them. One example is Flavius Josephus' record of the terminal sufferings and death of Herod the Great. The great Jewish historian chronicled Herod's final days in surprising detail, recording both public and private aspects. As a result, we are left with a unique insight into his personality and a summary of his symptoms and physical ailments. This sets the stage for a re-evaluation of Herod's final illness from the perspective of contemporary medicine. Josephus describes Herod's illness in both Antiquities of the Jews1 and The Jewish War2. For the most part, the accounts are complementary. The clearest description of Herod's symptom complex is found in TheJewish War:


An ethnographic and diachronic examination of the commemoration of violent events— battles and massacres—in Palestinian refugee camps in Lebanon shows the shift in mnemonic frames that helps one to understand political contention and strategies of struggle. The transformations in the representation and remembrance of battles and massacres in response to particular audiences and contexts reveal the dynamic and constructed nature of commemorative practices. The persistence of some commemorative narratives at times and their oblivion at others depend on the character and role of local institutions on one hand—political organizations or nongovernmental organizations—and the available and authorized transnational discourses on the other.


Sampson (1952) in his discussion of range utilization poses two important questions: "How closely may a range area be grazed without damage to forage stand and soil?" and "How may one determine how closely a range unit has been grazed?" Obviously, standards of use which are implied in the first question cannot be answered unless reliable methods for measuring various degrees of use are developed. Several reviews and comparisons of methods for measuring range use have been published (Pechanec and Pickford, 1937; Clark, 1945; Heady, 1949; Brown, ,1954; Ragsdale, 1956) . However, Heady stated that the real problem is not the measurements of use but the interpretation of those measurements. This conclusion is supported by Harris (1954) who reported that for a ten-year period on the Starkey Range in northeastern Oregon yearly utilization of bluebunch wheatgrass (Agropyron spicatum) varied from 38 to 69 percent, yet the average for the period was close to 50 percent. He concluded that any adjustments in stocking rate on a basis of year to year use would not be justified. Since methodology used in appraising range utilization has been the subject of most earlier papers, this article will be primarily concerned with interpretations of these measurements in terms of plant and animal responses. Specifically, the purpose of this paper is twofold: (1)


This chapter will explore the attitudes of young women between the ages of 18-25 years towards romantic relationships in the slums of Nairobi, with a view to wider lessons for young women in other societies. Through four case studies examining the lives, relationships and motherhood experiences in Mukuru Kwa Ruben slum, key themes are suggested to explain the high rate of early and single motherhood. Through the construct of 'relationship literacy,' the chapter will suggest that poor or non-existent male role models, weak or negative experiences of committed relationships, combined with harsh socio-economic consequences have resulted in young women having a little notion of what a real relationship is or what commitment is about. In the conclusion, it is suggested that to achieve improved relationships and life chances for young women both in the slums and well beyond, it is vital to focus on promoting and enhancing the relationship literacy of girls and young women, to enable them to make effective life choices.


The complex‐coordinate coupled‐channel (CCCC) formalism previously developed [J. Chem. Phys. 72, 4772 (1980)] is applied to the accurate determination of the level widths (lifetimes) and energies of rotationally predissociating metastable Ar⋅⋅⋅H2 van der Waals molecules. Calculations are performed using several realistic anisotropic potentials obtained recently by experiments, including Lennard‐Jones (LJ), Buckingham–Corner (BC) type potentials, as well as the semiempirical potential of Tang–Toennies (TT). New numerical methods are introduced here to deal with the complex rotations of piecewise inhomogeneous potentials such as those of BC and TT. It is found that the CCCC method is capable of providing reliable results for any given potential surface. Furthermore, the CCCC results are sensitive to the potential surfaces used. For example, the linewidths predicted for different LJ potential surfaces considered here vary by a factor as large as 4. However, the agreement among more recent potentials, namely, the BC potential of Zandee and Reuss and that of Le Roy and Carley as well as the potential of Tang and Toennies, is much closer: the resonance energies agree to within 1 cm−1 and the linewidths to within 30%.


The aim of the study was to investigate the influence of discrete structural differences in synthetic porphyrins on the antineoplastic effect induced in myelocitic cell line K562 after experimental photodynamic therapy procedure. For this study, we used 5,10,15,20-tetra(1-naphthyl)porphyrin, 5,10,15,20-tetra(4-sulfonatophenyl)porphyrin and their Zn complexes. For all these compounds, the following photodynamic therapy parameters were optimized: cell concentration, dye loading concentration, loading time and irradiation procedure. The non-toxic doses of porphyrins were different according to their structure: for 5,10,15,20-tetra(1-naphthyl)porphyrin compounds, the dose was of 10 μg.mL-1, and for 5,10,15,20-tetra(4-sulfonatophenyl)porphyrin compounds, the dose was 20 μg.mL-1. Cell functionality was assessed as membrane integrity, viability, and number of metabolically active cells. Photodynamic cell degradation kinetics showed that during irradiation tumor cells are actively destroyed, in contrast to unloaded cells. K562 cells loaded with the above-mentioned compounds and subjected to irradiation, displayed lower proliferative capacity compared to the control, for a period of 72 h after irradiation. The proliferative capacity of K562 cell line was more strongly inhibited by the 5,10,15,20-tetra(1-naphthyl)porphyrin family of compounds than by the 5,10,15,20-tetra(4-sulfonatophenyl)porphyrin family. The tested synthetic porphyrins showed effective antineoplastic activity against K562 leukemia cells in our in vitro photodynamic therapy experimental model.


Traditional control allocation technology may introduce large control output error when the control effectiveness model has uncertainties. This paper demonstrates a new robust control allocation method in the presence of partial or total loss of control effectors. Under the condition that the fault magnitude information is not identified precisely, the robust control allocation method considers the uncertainty in the control effectiveness model and outputs the solution with the minimal virtual control error in the worst case. The robust control allocation problem can be cast into a second order conic programming problem, which can be solved by primal dual interior point method. The paper will investigate the performance of the robust control allocation method by comparing the numerical simulation results with other known control allocation methods.


The primary aim of this study is to demonstrate the important historical contribution made by written accounts of Ottoman and European travelers regarding Ottoman musical practices. This article reflects information gleaned from a larger research project that ultimately aims to illuminate the role and usage of various Ottoman-era instruments that have been forgotten in the modern era. Obscured in the vast span of time, these instruments are now historical and cultural artifacts that have been unnecessarily marginalized in our contemporary times . In this study, the musical lives of the Ottomans and their musical instruments are discussed through the perspectives of Ottoman and European travelers, including as Evliya Celebi, Guillaume Postel, Johannes Lewenklau, Cane, du Loir, d'Ohsson and Julia Pardoe. In addition to the narratives of these travelers, Ottoman miniatures are used as revealing visual resources to identify and categorize forgotten musical instruments. The compelling connection between these two resources may become the first step towards rejuvinating awareness and understanding of the cultural significance of these instruments as colorful pieces in the mosaic of Turkey's multi-faceted artistic heritage.


NCREASING EXPERIENCE WITH OPERATIONS~' 2 I involving pelvic exenteration has shown that among 503 such procedures performed between 1947 and 1956, inclusive, which entailed urinary tract diversion, 99 patients survived 5 or more years (19.7% survival). In the continued pursuit of such a program for advanced pelvic cancer, mostly cancer of the cervix, a review of the results related to preoperative findings has been carried out from time to time in order to gain some impressions as to what signs and symptoms may prognosticate gomi or poor chances for prolonged survival. Early in these experiences it was learned that exenterations performed for relief of pain but in which all macroscopic evidence of cancer was not excised from the pelvis, postoperative survival was generally so brief and the incidence of postoperative complications so great that they were indeed not worthwhile. AIso it was learned that similar results would follow if periaortic lymph node metastases were left behind although all macroscopic cancer was excised from the pelvis. Since involvement of 1 or both ureters is a common finding in candidates for pelvic exenteration and since nonvisualization of 1 or both kidneys upon intravenous pyelogram is a frequent preoperative finding, it became obvious that a review of the results in terms of 5-year survival and related to preoperative nonvisualization of 1 or both kidneys was desirable in order to ascertain if such preoperative findings would afford a prognostic sign of some significance.4 Omitting detailed discussion, it is nevertheless important to state our criteria for non-


The effect of a Ti underlayer on Co-Cr thin film was investigated from the crystallographic and morphological points of view. The Co-Cr film on a Ti underlayer has a larger perpendicular magnetic anisotropy and coercive force than that deposited directly on a polyimide film substrate. It is found that the improvement of perpendicular magnetic properties by the insertion of a Ti underlayer is not due to the improvement of the crystallographic c-axis orientation, but is due to the formation of a uniform columnar structure.


In this paper, 3D printing is used as an alternative manufacturing technique to fabricate metamaterial-inspired RF structures for liquid profiling. A dual split-ring resonator (SRR) based sensor tag is designed and integrated with a microfluidic channel for detecting different liquid samples. The sensor is 3D printed using a high-temperature resin and metallized using a custom developed metal patterning process. The sensor requires a very small volume of 8.6 μL of sample under test for detection. The resonance frequency of the SRR changes with change in sample loading and the shift is monitored for sample profiling. Different volatile organic compounds are introduced and the shift is monitored demonstrating the sensitivity of the proposed tag. The low-cost, real-time nature of the tag makes it an ideal choice for monitoring liquids along the supply chain.


The provision through journals of professional support for teachers in schools is a matter of wide concern in Britain. Demographic and economic trends require school administrators and teachers to adapt to fundamental changes of purpose while undergoing major contraction in student numbers, staff and physical resources. Adaptation and innovation can no longer be managed by recruiting teachers with fresh kinds of expertise, as was done in the 1960s and early 1970s; instead, the developments which are or which will shortly become imperative will have to be carried out mainly by teachers already in post. Staff renewal and retraining are, therefore, of paramount importance (Bailey 1982a). One way of bringing this about is publishing journals which keep teachers abreast of new ideas and report on examples of successful practice. Many professional journals exist in Britain. They are produced by subject teaching associations, such as the Geographical Association; by Local Educational Authorities for their own teaching forces, such as the Inner London Education Authority; and by bodies having a more general educational interest, as for example in the development of the curriculum or in school organization and management. Unfortunately the impact of many such journals on practical teaching is limited. An examination of their contents suggests why this is so. Few attract contributions of a practical nature from school teachers themselves. Rather they f i l l their pages with articles written by teacher-educators, by subject specialists in universities and polytechnics, by school advisers and inspectors, and others not involved in the day-to-day teaching of school-age students. The standard of scholarship and writing in these articles is often high, but their practical usefulness is low. Many articles deal with innovation in subject content which, though valuable in itself, does nothing to improve the process of education. Others describe carefully prepared teaching projects, many of which depend for their success upon having a great deal of time for preparation andlor student-teacher help in the classroom. No teacher working alone under normal school conditions can replicate them. Domination of the journals by college teachers is self-perpetuating because it discourages school teachers from writing. Journals are perceived in schools as being written by "them" rather than by "us." A vicious circle of theorizing and unreality is set up which a journal editor finds difficult to break. Meanwhile low subscription levels for many journals intended for teachers show that teachers find few of them useful. One relatively new journal, written for and substantially by teachers of geography in British schools, has succeeded in overcoming this problem to some extent. This is Teaching Geography, the journal of the Geographical Association devoted to practical teaching. Now in its eighth year of publication, Teaching Geography is firmly established as a quarterly journal which publishes about fifty articles annually for a readership of about 5,000 subscribers. About one-half its Pafrick Bailey studied geography at Cambridge and McGill Universities and education at Cambridge. He has taught in a variety of schools and in teacher education colleges and is now senior lecturer in education in the University of Leicester School of Education, Leicester, England LE1 7RF. He is active in initial teacher training and in diploma and higher degree work with practicing teachers in the fields of geographical education and education management. He has published numerous papers in both fields.


There are four Option Generation products being developed as part of Project B. This one addresses how to improve the development of scheme options involving local residents and generating potential transport solutions that may be considered 'out-of-the-box' or novel – i.e. not "out of the bottom drawer" or rehashes of previous plans. The tool is designed to engage with so called 'hard-to-reach' stakeholder groups.


Northwest China is short of water, where the water ecosystem environment is vulnerable. This article analyzes the water volume, water quality, water environment and water security etc. in the water ecosystem of Guanzhong-Tianshui Economic Region of northwest China in a systematical way, and makes suggestions on what and how to improve the situation there from two aspects: the content of governance and the mode of governance, illustrating the importance of the construction of water ecosystem and providing references for the construction of water ecosystem in Northwest of China.


Graphite-based dual-ion batteries are with potential higher energy density, making them a unique advantage in energy storage system. However, oxidative anion insertion into graphite in aqueous environment represents a significant challenge. Herein, we report that the reversible insertion of Al-Cl superhalide into expanded graphite (EG) delivers an ultrahigh specific capacity of ~171 mAh g-1 from an aqueous deep eutectic solvent (DES) gel electrolyte of 50 m ChCl + 5 m AlCl3. High-resolution transmission electron microscopy (HRTEM), Raman spectra and X-ray diffraction (XRD) show that the EG generates turbostratic structure of during Al-Cl superhalide (de)insertion instead of presenting typical graphite intercalation compounds (GIC), thus attributing to the high capacity during Al-Cl superhalide insertion.


The naturally occurring radionuclides (radium, thorium, potassium and radon) were investigated in the alkaline rocks of Abu Khuruq Ring, southern Eastern Desert, Egypt. High-Resolution Germanium detector was used for the detection of 40 K, 232 Th, and 226 Ra (Canberra, GR4020 model) while 222 Rn concentration was measured by AlphaGuard Saphymo GmbH system, model PQ 2000 (AG). Positive correlation was observed between effective radium content and radon concentrations pointing to the strong linear dependency between both contents in the studied rocks. The average values of activity concentration of 40 K, 232 Th, 226 Ra, and 222 Rn were little more than the suggested level by a factor of 1.38%, 3.16%, 2.09%, and 1.16%, respectively. Significant variations were observed between radiological hazards parameters, e.g., the mean value of annual effective dose (0.55 mSv y -1 ) was more than the global reference value of 0.41 mSv y -1 by a factor of 1.34. The calculated average value of gamma index was 0.90, whereas the calculated average value of alpha index was 0.37. Hex, Hin and Raeq showed less average values than the standard values of unity and 370 Bq kg -1 , respectively.


Abstract:In this article, I explore negotiations of alternative Jewish identities as a response to the Holocaust in two alternative histories by the Jewish American writers Michael Chabon and Simone Zelitch. Both engage in very different ways with the destruction of a physical Yiddishland in central and eastern Europe and explore notions of Jewish guilt and the projection of Jewish identities into the future. In The Yiddish Policemen's Union (2007), Chabon explores the imaginary persistence of Yiddish language and culture in a Yiddishland that, after a mitigated Holocaust, has been transferred to Alaska. The Yiddishland in Zelitch's Judenstaat (2016) is divested of its Yiddishness. Jewish statehood after the Holocaust is conceived in her novel in retributive guilt and relies upon a potent imaginary of Jewish Germanness which, extends to culture, language, and territory in an illusory continuation of a mythical Ashkenaz and eventually ends in the dissolution of Jewish sovereignty.


Using immunocytochemical techniques at the light and electron microscope levels, Legionella pneumophila and one of its extracellular proteases were located in the lungs of guinea pigs with experimental Legionnaires' disease (LD). L. pneumophila was immunostained by several peroxidase‐ and gold‐labelling methods for light and electron microscopy. The protease was immunolabelled in tissue fixed in Carnoy's fluid at the light microscopical level and on broth‐grown organisms at the ultrastructural level. It was not labelled in either formalin‐ or glutaraldehyde‐fixed tissue.


Image representation and distance metric are both significant for learning-based visual classification. This paper presents the concept of k-nearest-neighbor simplex (kNNS), which is a simplex with the vertices as the k nearest neighbors of a certain point. kNNS contributes to the image classification problem in two aspects. First, a novel distance metric between a point to its kNNS within a certain class is provided for general classification problem. Second, we develop a new subspace learning algorithm, called discriminant simplex analysis (DSA), to pursue effective feature representation for image classification. In DSA, the within-locality and between-locality are both modeled by kNNS distance, which provides a more accurate and robust measurement of the probability of a point belonging to a certain class. Experiments on real-world image classification demonstrate the effectiveness of both DSA as well as kNNS based classification approach.


PurposeMicrofiber is one of the major sources of microplastic emission into the environment. In recent times, research on microfiber has gained momentum, and research across different disciplines was performed. However, no complete study was performed from the viewpoint of textiles to analyse the microfiber shedding behaviour by relating the properties textiles. The purpose of this paper is to analyse the microfiber shedding behaviour in textiles.Design/methodology/approachArticles on the microfiber shedding across different disciplines were collected and analysed systematically to identify the influencing factor. The influence of laundry parameters is found to be majorly discussed section, yet very few research data is found on the effect of yarn and fabric properties on the microfiber shedding.FindingsMost of the articles listed laundry detergent addition, higher temperature, use of softeners, type of washing machines used and amount of liquid used as the major factors influencing the fiber shedding. Concerning the fiber and yarn characteristics, yarn twist, fiber type (staple/filament), method of production, fabric structure and specific density are reported as influencing factors. Some articles highlighted the influence of ageing of textiles on the fiber shedding.Originality/valueThe review identified the research gap in the textile sector and reports that so far, no research performed on microfiber shedding with the textile parameters. The review further urges the importance of research works to be performed in the textile by considering the fabric and yarn properties.


Dual-gate organic thin-film transistors (OTFTs) of octathio[8]circulene (1) with ionic liquid and SiO2 gate dielectrics lead to good transistor performance with a high on/off ratio (∼105), a low threshold voltage (∼−5 V), a low subthreshold slope (∼150 mV/decade), and low power operation, thus surpassing the performance of the single-gate OTFTs of 1. This operation is a promising method for improving the carrier concentrations in OTFTs and for realizing high-performance OTFTs.


In this paper, a scheduling problem with continuous resource and energy constraints is addressed. Given a limited resource capacity and a set of tasks, the objective is to find a schedule such that each task is processed in its time window and uses a quantity of the resource between a minimum and a maximum value. In addition, each task requires an energy demand; this energy follows a function of the amount of resources allotted. For the cumulative scheduling problem a polynomial satisfiability test exists. Here, we adapt this test to the case of linear and piecewise linear functions.


Diaphragm wall was adapted to as exterior-protected construction in the design of deep foundation pit when the displacement was controlled strictly. Construction measurement and the deformation of diaphragm wall were discussed based on the Mo'er foundation pit close to metro line No.1. The results showed that foundation consolidation between the inside and outside of the foundation pit and construction in "layered,partitioned,time-limited excavation" were beneficial to the safety of metro tunnel.


Receiver-driven TCP protocols delegate key congestion control functions to receivers. Their goal is to exploit information available only at receivers in order to improve latency and throughput in diverse scenarios ranging from wireless access links to wireline and wireless Web browsing. Unfortunately, in contrast to today's sender-driven protocols, receiver-driven congestion control introduces an incentive for misbehavior. Namely, the primary beneficiary of a flow (the receiver of data) has both the means and incentive to manipulate the congestion control algorithm in order to obtain higher throughput or reduced latency. We study the deployability of receiver-driven TCP in environments with untrusted receivers which may tamper with the congestion control algorithm for their own benefit. Using analytical modeling and extensive simulation experiments, we show that deployment of receiver-driven TCP must strike a balance between enforcement mechanisms, which can limit performance, and complete trust of end-points, which results in vulnerability to cheaters and even DoS attackers.


Poster: "ECR 2016 / C-0667 / Who is the winner? Analysis of efficacy in percutaneous sclerotherapy of macrocyst linfangiomas according to sclerosing agent used " by: "V. Navarro Cutillas, C. Gallego Herrero, M. Arroyo Lopez, N. Guerrero Salcedo, M. D. Delgado Munoz, C. Marin Rodriguez; Madrid/ES"


Inventors: Naoyuki Tokuda, Tokyo (JP); Liang OTHER PUBLICATIONS Chen, British Columbia (CA); 66 Hiroyuki Sasai, Tokyo (JP) A Corpus-based probabilistic Grammar with Only Two Non-Terminals' Satoshi Sekine and Ralph Grishman, Assignee: SunFlare Co., Ltd., Tokyo (JP) (1996), 4" International Workshop on Parsing Technology, pp. 216-233-Apple-Pie Parser. Notice: Subject to any disclaimer, the term of this * cited bw examiner patent is extended or adjusted under 35 y U.S.C. 154(b) by 670 days. Primary Examiner-Antony Nguyen-Ba (74) Attorney, Agent, or Firm-Jacobson Holman PLLC Appl. No.: 10/072,973 (57) ABSTRACT Filed: Feb. 12, 2002


The ageostrophic wet Q-vector method is applied to diagnose a torrential rainfall process in Shandong Peninsula on August 1,2001,which is caused by a temperate cyclone transformed from typhoon "Toraji"moving northward. The results show that there is a good relation between the area of torrential rainfall and the negative area of divergence of ageostrophic wet Q-vector. By advance of 6~12 hours,the divergence of ageostrophic wet Q-vector at 925 hPa makes a good index to heavy rain in Shandong Province. The ageostrophic wet Q-vector method is a good tool for forecasting the heavy rain in the province. It can give a strong signal about the torrential rainfall area in advance,and using it to forecast torrential rain area is much better than using the field of divergence and the divergence of water vapor flux. It serves as a new good way to forecast torrential rainfall in the province. The increase of temperature and humidity is more obvious at 925 hPa than at 850 hPa,which may be partly one of the reasons why the divergence of ageostrophic wet Q-vector at 925 hPa is a good index in this torrential rainfall process.


This paper deals with investigations on loads from wave-induced shock pressures on seadykes with composite slopes and berms. The investigations have been done with large scale laboratory tests, using different wave climate characteristics (regular waves, PM spectra and field spectra). Two different types of dyke cross-sections have been investigated: one with an upper slope 1:6 and a berm in front, and the other one with composite slopes 1:3 in the lower part and 1:6 in the upper part. The presented results were discussed with respect to the influences of wave climate, of absolute waveheights and of geometrical conditions. Introduction Due to the increasing of storm surges and the supposed long-term rising of water levels at the coastlines of the North Sea, wave loads on seadykes have become again more important for savety analysis of excisting dykes. Air entrainment and wave climate characteristics under real sea state conditions play an important role both on shock pressure occurrence and on wave run-up process. Thus boundary effects and scale effects have to be minimized by using field data or large scale laboratory test data. The results presented in this paper were obtained from large scale laboratory tests in the "Large Wave Channel" (GWK) at Hannover, Germany, within an extensive research program on stability on sloping seadykes and revetments ( supervision Prof. Fuhrboter + ), which had been supporting partly by the German Research Foundation ( DFG ) for more than 10 years. Previous results from this research program on wave loads on uniform slopes have been reported recently for example by Grime (1992) for shock pressures and by Sparboom, Grtine, Haidekker & Grosche ( 1990 ) for wave run-ups. Dipl.-Ing., Senior researcher, Deputy Operation Manager of Joint Institution Large Wave Channel (GWK) of the University of Hannover and the Technical University of Braunschweig, Merkurstrasse 11, 30419 Hannover, Germany. 2 Dipl.-Ing., Researcher, Hydrodynamic and Coastal Engineering Dept. of LeichtweiB Institute of the Technical University of Braunschweig.


Written in Latin or secular languages and printed by commercial or religious presses, Jesuit accounts of the order's overseas missions were a popular genre in Early Modern and Enlightenment Europe. Chronicles of frontier missions to the mobile Indians of the Americas were published by commercial printers as early as the 1590s. Their audience ranged from ecclesiastics seeking edification or training as missionaries to an increasingly wealthy and literate secular reading public, who considered them material for leisure reading. Among different European language book markets, the Spanish case was unique in its distinctly Atlantic character and geographic extent. The Jesuits were particularly adept and prolific at writing about non-Western peoples for European readers. Three factors were instrumental in this. The first was the order's sprawling network of colleges, residences, and missions, which gathered vast amounts of information about natural history and ethnography. Second, a corporatemilitary structure produced numerous reports from the field addressed to superiors in Rome; the published versions of these sources became popular due to their striking


(57) [Summary] The present invention relates generally to the field of psychiatry. In particular, the present invention relates to the discovery that agents which inhibit the binding of cortisol to its receptor can be used in a method for treating dementia. Mifepristone (strong glucocorticoid receptor antagonist) can be used in these methods. The present invention also provides a kit for treating dementia in humans (indications of administration of the glucocorticoid receptor antagonist and glucocorticoid receptor antagonists, include instructions teaching the dosage and schedule).


The only guidelines for sample size that exist in the multidimensional scaling (MDS) literature are a set of heuristic "rules-of-thumb" that have failed to live up to Young's (1970) goal of finding func tional relationships between sample size and metric recovery. This paper develops answers to two im portant sample-size questions in nonmetric weight ed MDS settings, both of which are extensions of work reported in MacCallum and Cornelius (1977): (1) are the sample size requirements for number of stimuli and number of matrices compensatory? and (2) what type of functional relationships exist between the number of matrices and metric recov ery ? The graphs developed to answer the second question illustrate how such functional relation ships can be defined empirically in a wide range of MDS and other complicated nonlinear models.


The excitation, distribution, and interaction of surface acoustic waves (SAW) and pseudo surface acoustic waves (PSAW) in a X-cut lithium niobate substrates were investigated. The resonant excitation frequencies, the wave distribution velocities and the dispersion characteristics were determined for each of the wave types. The influence of the interdigital transducer (IDT) material on the excitation efficiency and the interaction between investigated wave types was found out. The interdigital transducer material and configuration requirements for integrated acousto-optic devices were determined.


In any multi-actor environment, there is an inevitable trade-off between achieving global coordination of activities and respecting the autonomy of the actors involved. Agile and resilient behaviour demands dynamic coordination capabilities, but task and resource allocation quickly becomes a demanding challenge in joint NEC environments because of individual constraints and demands. In this paper, we present work on adaptive autonomy in multi-agent organizations. We have been researching the relationship between autonomy and coordination, and developed an agent reasoning model that enables collaborative task coordination, but also guarantees individual autonomy – the capability to self-manage behaviour. We define autonomy as the amount of influence other agents have on one's decision making process. We have given the agent options to adapt its openness to external influences, so it can change its own level of autonomy. This allows agents to select the level of autonomy that best fits the circumstances, given a certain tasking, individual policies and organizational structure. We have incorporated this concept in a practical model and added heuristics for environmental events, information relevance and organizational rules. Our approach addresses fundamental collaborative challenges in NEC environments, and may bring about new perspectives on autonomy in collaborative environments.