To the Editor: In a recent article in the Journal of the American Geriatrics Society, Carpenter and colleagues found that disclosure of a dementia diagnosis does not prompt a catastrophic emotional reaction in most people with dementiaFnot even in those who are cognitively only mildly impaired. Companions of these patients also remained stable or even declined in their emotional stress immediately after the disclosure of dementia diagnosis. These findings suggest that physicians can provide a dementia diagnosis to a patient without fear of prompting strong emotional reactions. In our experience, the disclosure of a diagnosis of dementia and adjustment to understanding all dimensions related to this information are a long-term process in which the patient's feelings develop and change over time. We examined the experiences of spousal caregivers of patients with Alzheimer's disease (AD) with many comorbidities and disabilities regarding the disclosure of dementia diagnosis and the subsequent need for advance care planning (ACP).


Light scattering spectra, both stationary response for monochromatic excitation and time-resolved response for pulse excitation, at zero temperature are calculated in the model of a Frenkel exciton coupled to Einstein phonons, by using the dynamical coherent potential approximation. For resonant excitation, calculated spectra are characterized by hot luminescences from a nearly free exciton state and also from vibronic states of a self-trapped exciton. Calculated time-resolved spectra manifest exciton-phonon dynamics involving these states, such as configurational tunneling between the free state and the self-trapped state.


PurposeA discussion piece of how apprenticeships can be used by HEIs as employers.Design/methodology/approachThe paper explores the current apprenticeship landscape; what HEIs are already doing with apprenticeships; the arguments for using apprenticeships in the sector. There is then a case study on how the University of Birmingham uses apprenticeships before a discussion about future directions.FindingsThe paper reports that although there are a range of advantages for using apprenticeships, HEIs could still use apprenticeships more.Originality/valueThis paper uses a range of sources as detailed in the reference.


Grossmann, Johannes, Susanne Mohr, Eduardo G. Lapetina, Claudio Fiocchi, and Alan D. Levine. Sequential and rapid activation of select caspases during apoptosis of normal intestinal epithelial cells. Am. J. Physiol. 274 (Gastrointest. Liver Physiol. 37): G1117–G1124, 1998.—Detachmentinduced cell death (DICD) is considered to be one of the means by which intestinal epithelial cells (IEC) die of apoptosis as they reach the lumen and are shed. Caspases, a family of cysteine proteases, play a central role in initiating, amplifying, and executing apoptosis; however, the pattern of caspase activation in response to distinct apoptotic stimuli remains unknown. We investigated the kinetics of caspase activation during DICD in freshly isolated human IEC. DNA fragmentation is observed 90 min after detachment and is preceded by the sequential activation of preformed members of the CPP32 family of caspases. Activation of caspase 6 and cleavage of the endogenous caspase substrate poly(ADP-ribose) polymerase (EC 220.127.116.11) are detected within 15 min of detachment, 30–45 min before caspase 3 activation. Caspase 1 and caspase 10 are present as proenzymes, yet they remain inactive in response to this trigger of apoptosis. Human IEC are primed to rapidly undergo detachment-induced apoptosis involving the selective and sequential activation of preformed caspases. This study may enhance our understanding of physiological events occurring as IEC are shed. Their rapid apoptotic response to detachment may facilitate the high turnover of cells and ensure homeostasis in the intestinal epithelium.


We estimate producers' value of information provided by alternative configurations of a monitoring network for an invasive wind-borne crop disease, soybean rust (Phakopsora pachyrhizi). Soybean producers use monitoring information to inform themselves about their risk of being infected and to make fungicide application decisions. The value of information is the expected gain in producers' profit associated with the use of the monitoring network, and we estimate this with a dynamic model of producer decisionmaking. We find that the value of the sentinel plot network increases with the number of sentinel plots, reaching a maximum at 400 sentinel plots. In addition, the optimal spatial arrangement of sentinel plots indicated by our model is substantially different from actual placements. Current sentinel plots are disproportionately placed in the Southern US where the risk of infection is high, but the amount of soybean is relatively small. Our estimates suggest more plots should be placed in the Corn Belt where the risk of an infection is lower, but where much more soybean is produced.


We develop a novel argument why better public information can help countries to insure against idiosyncratic risk. Representative agents of developing and industrial countries receive public and private signals on their future income realization and engage in risk-sharing contracts with limited enforceability. Better public information has two opposite effects. First, it has a detrimental effect on risk sharing by limiting risk-sharing possibilities as emphasized by Hirshleifer (1971). Second, it mitigates the adverse selection problem resulting from private information which improves risk sharing. We find that better public information in developing countries ameliorates risk sharing in both developing and industrial countries.


Previous work has demonstrated how interactive systems can be modelled formally as a collection of interacting objects or agents using an agent-based specification language (Abowd 1991, Duke & Harrison, 1992). An agent is an object which encapsulates some private internal state and operations which may alter this state together with an external view which describes the behaviour of the system in terms of the user interface level events which occur and the rendering function by which the object makes aspects of its internal state visible to the environment.


As an economic agent, Entrepreneur has a major contribution to the country's economic growth. There are many entrepreneurship programs developed to encourage entrepreneurship, and Student Entrepreneurship Program at Hasanuddin University is one of them. However, there are many challenges and difficulties faced in running a business cause failure during early years. This study aims to examine Adversity Quotient (AQ) and perception of adversity in distinguishing students who continue their business and do not continue their business. This research is a quantitative research with explorative-descriptive research design. There are 66 students consist of 33 students who continue their business and 33 students who do not continue their business participated in this research. The data were obtained by open-ended questions to explore perceptions, adaptations of the Adversity Response Profile scale to measure Adversity Quotient (AQ) and Motivation Scale constructed by investigator based on motivational theory from McClelland (1961). The result of this study shows that there is no difference of perception of students who continue their business and do not continue their business. However, there are differences in AQ and the motivation of students who continue their business and do not continue their business. Adversity Quotient (AQ) in the students who continue the business is in the high category of 52% and the medium category of 48%. While the students who did not continue the business showed high category 36%, medium category 61%, and low category 3%. Keywords—Adversity Quotient; perception


We present a set of experimental results concerning the power spectrum of current noise, detected on a granular high Tc superconductor submitted either to a slowly varying magnetic field or to a varying current intensity. Experiments were performed on a YBCO specimen suitably treated in order to weaken the weak links without affecting the oxygen content of grains. The weakening of the intergrain region allowed the use of very small magnetic fields and currents to induce the resistive transition of the specimen and to observe current noise. The induced noise is of the 1/f2 type and will be interpreted in terms of two different models. One of the model is based on the enhancement of the noise due to the clustering of the resistive transition of the weak links, produced by correlation effects related to the strong nonlinearity of their Josephson type I-V characteristics. This model has been the object of a computer simulation based on a 3D-network of Josephson-like elements and seems suitable to explain the noise produced by current variation. The second model explains the excess noise as produced by discontinuous penetration of the magnetic flux inside the intergrain region. This discontinuity is related to the field screening effect of rings made of several superconducting weak links connecting different grains, which are alternatively broken and restored by the current induced during flux variation, and seems suitable to explain the larger noise produced by a varying magnetic field.


Antennatus linearis is described as a new species of frogfish (family Antennariidae) from three specimens from the Hawaiian Islands, one from the Molucca Islands, one from Aldabra, and four from Mozambique and Natal, South Africa, the largest 60 mm standard length. It is distinct from the wide-ranging Indo-Pacific A. tuberosus in having a caudal peduncle, 9-10 instead of 11-12 (rarely 10) pectoral rays, usually all or all but one of the pectoral rays branched (usually all simple in A. tuberosus), longer and more widely spaced dermal spicules, and a longer second dorsal spine (10.5-13.4% SL, compared with 6.5-9.8% for A. tuberosus). It differs from the eastern Pacific A. strigatus and the Japanese A. flagellatus in having the illicium 1.55-1.95 times longer than the second dorsal spine (about equal to the second spine in A. strigatus, and about 3.6 times longer in A. flagellatus). It differs from all three species in its striking pattern of curving dark lines on the head and body.


Water is a vital natural resource that occurs on the earth. In many places having fresh and clean water is a crucial issue. This study focuses on the removal of turbidity and total dissolved solids from aqueous using Emblica Officinalis and Cannabis Sativa Leaf Powder. The results were found that turbidity removal increases with an increase in pH value with different dosage and concentration. However, the percentage of removal of total dissolved solids starts decreasing after a certain pH i.e. at pH 9 for individual experiments and pH7 for combined


We describe a method for sensitivity communication robots which infer their dialogist's emotion. The method is based on the Bayesian approach: by using a Bayesian modeling for prosodic features. In this research, we focus the elements of emotion included in dialogist's voice. Thus, as training datasets for learning Bayesian networks, we extract prosodic feature quantities from emotionally expressive voice data. Our method learns the dependence and its strength between dialogist's utterance and his emotion, by building Bayesian networks. Bayesian information criterion, one of the information theoretical model selection method, is used in the building Bayesian networks. The paper finally proposes a reasoner to infer dialogist's emotion by using a Bayesian network for prosodic features of the dialogist's voice. The paper also reports some empirical reasoning performance.


Modern cities suffer immensely from traffic congestion caused mainly by the proliferation of private vehicles on the road network. Park-and-Ride (P&R), an already established critical infrastructure system, encourages commuters to drive from their trip origin to train stations or bus terminals, where they park and ride public transport (bus, train or tram) to their destination with the objective of mitigating traffic congestion. Traffic congestion adversely affects the roadway capacity thus making the traffic condition on the network uncertain. Therefore, the need for reliable transport system is an increasing demand for transport network users. Reliability of network is one of the key indicators for the evaluation of transport network performance. Optimisation of network reliability for P&R network has not been studied yet. Consequently, the P&R network design in a bi-modal transportation system considering the network reliability is a novel area in transport research. Commuters manifest different types of behaviour when tackling unstable traffic condition in transportation network. This behaviour can be known as risk-aversion, risk-neutral and risk-seeking. Travel time disutility associated with the aforementioned behaviours is taken as reliability measurement for the evaluation of network performance. A Bi-level programming model is developed to determine the optimal P&R scheme in a bi-modal transport network with the objective of optimising network reliability. Optimal P&R scheme includes optimal parking location and size which are determined considering real life commuters behaviour. The objective of the upper level is to minimize the total expected travel disutility in the whole network. The lower level is the commuters' route choice problem and travellers are assumed to choose the path/route with minimal expected travel disutility. This disutility-related multiclass user equilibrium is formulated as nonlinear complimentary problem which is a non-additive path cost problem. A Genetic Algorithm (GA) is implemented to solve the bi-level model and verified by a numerical example considering a P&R network.


ABSTRACT
This study sought to determine whether the cannabis constituent, cannabidiol (CBD), is able to attenuate morphine reward in the conditioned place preference (CPP) paradigm. Mice received IP injections of either saline or morphine and increasing doses of CBD that were paired with a distinct environment in the CPP apparatus. Morphine-produced place preference was dose-dependently blocked by CBD. Furthermore, none of the tested doses of CBD exhibited reward or aversion. The finding that CBD blocks opioid reward suggests CBD may be useful as an abuse deterrent, particularly in the setting of opioid use for pain management.


The trade-off theory of corporate cash holdings predicts that there is an optimal level of cash. We test the trade-off theory by investigating the relation between deviations from optimal cash holdings and the valuation of cash from a shareholder's perspective. We decompose corporate cash holdings into the optimal level of cash and the deviations from the optimum. We find that the marginal value of cash for shareholders is higher when a change in cash moves corporate cash holdings towards the optimal level and that this relationship holds for both the above-optimal deviations and the below-optimal deviations. We conclude that the results are consistent with the prediction of the trade-off theory of corporate cash holdings.


We aimed to identify the virulence and antimicrobial resistance features in Carbapenem Resistant Acinetobacter baumannii (CRAB) strains isolated from hospital settings and compare them with those isolated in the same period of time from community acquired (CA) infections in Bucharest, south of Romania. A total number of 93 A. baumannii strains were isolated in majority from hospitalized patients and from CA infections. The resistance and virulence mechanisms of the strains were characterized by phenotypic and genotypic methods. The antibiotic resistance profiles in H and CA A. baumannii isolates revealed high percentages of carbapenem-resistance in both H and CA isolates. The ciprofloxacin resistance was found very closed in both types of isolates (84%/83.33%). CRAB H and CA isolates revealed the intrinsec carbapenemase OXA-51and the acquired carbapenemases OXA-23, OXA-24, IMP,and VIM-2. The blaOXA-23 gene was identified in different plasmid types (GR2-Aci1, GR6-pACICU2). rep135040, p3S18 and Aci6 in H A. baumannii isolates. The most frequently expressed virulence factor was lipase and DN-ase. OXA-51-like alleles corresponding to the two main sequence groups were identified as blaOXA66 (63.63% of the isolates) and respectively, blaOXA-69 (38.39%) and revealed the corresponding type of ompAand csuE sequence grouping.
AphA6 (24%/16.6%), AphA1 (16%/16.6%) and aadB (9.3%/5.5%) genes were responsible for aminoglycosides resistance. Our survey revealed a high drug resistance in A. baumannii isolates. Different plasmid groups containing CRAB isolates may facilitate the blaOXA23 dissemination.


This report describes the FY2013 appropriations for the Department of Homeland Security (DHS). The Administration requested $39.510 billion in adjusted net discretionary budget authority for DHS for FY2013, as part of an overall budget of $59.501 billion (including fees, trust funds, and other funding that is not appropriated or does not score against the budget caps). The request amounts to a $90 million, or a 0.2%, decrease from the $39.600 billion enacted for FY2012 through the consolidated appropriations act (P.L. 112-174).


We came across the 'two girls' version of the children's gender problem nearly 35 years ago. How we came to it we cannot remember, but Martin Gardner had published a variant of it in the Scientific American in 1959. It re-emerged for us in the summer of 2010, following the publication of an article in Science News [1]. Subsequently Keith Devlin wrote about how this re-emergence impacted on him, and noting that 'Probability Can Bite" [2]. The mathematics herein reflects and extends that in Devlin's article. In case the reader has not encountered the problem before, we first pose four problems. 1. A family has two children. One of them is a girl. What is the probability that they are both girls? 2. A family has two children. The younger is a girl. What is the probability that they are both girls? 3. A family has two children. One of them is a girl, and she was born on a Tuesday. What is the probability that they are both girls? 4. A family has two children. One of them is a girl, and she has green hair. What is the probability that they are both girls?


In June I776, the Continental Congress, meeting in Philadelphia, appointed committees to draft a declaration of independence and to prepare "the form of a confederation to be entered into between these colonies." The first committee was distinctly more successful than the second. Within a month, Congress approved the Declaration of Independence of which Thomas Jefferson was the principal drafter. Articles of Confederation were submitted to the states in 1777, but they did not take formal effect unti1 1781, when the last state, Maryland, gave its assent.


Abstract Magnetic susceptibility investigations of (4-XC5H4NH3)2FeCl2Br2, where X = Cl, OCH3 and H, are reported. Measurements were carried out on powdered samples in the temperature range 80 < T < 320 K at different magnetic field strengths. The results show that the susceptibility behaviour can be described in terms of an antiferromagnetic interaction which is masked by a weak ferromagnetic moment. A comparison is made with the susceptibility of the corresponding pure chloride compounds (4-XC6H4NH3)2FeCl4.


Health psychology has been mainly characterized by an individualistic and socio-cognitive perspective that demarcate its boundaries and fields of application. This results in making it less sensitive to the inequalities of the socio-political, economic and cultural determinants of health processes and to the changes and the innovative drives that characterized the onset of the new century. We need therefore to build new epistemological and methodological perspectives for 'reterritorialize' health psychology, abandoning or revisiting its mainstream guidelines. In this article I propose the metaphor of 'transhurbance' to suggest the urgency of a different approach to the needs and tensions in the contemporary cityscape, making it inaccessible to traditional approaches. Walking through the postmodern city districts, means getting in touch with a nomadic humanity, that doubtfully and contradictorily claims new content of citizenship. Together with this humanity, health psychology could redefine its positioning and research-intervention strategies. Two interventions in different urban contexts are presented in the appendix.  They exemplify the possibility to trace, through the methodologies of the 'derive' and of the 'participatory maps', possible work plans coherent with the vision proposed in this article.


Based on the triaxial dynamic test data of dam body rockfill material and asphalt concrete,empirical model of residual deformation for the filling material and dynamic constitutive model of the asphalt concrete are proposed in this paper.The static and dynamic finite element calculation model of composite dam with asphalt concrete core wall is built by the 3D FEM.Seismic permanent deformation of dam body and the different filling materials on the impact of seismic permanent deformation are also analyzed.The results show that the asphalt concrete core wall has good earthquake resistant behavior and the permanent settlement of the original designed dam body accords with the general law of the earthquake permanent deformation of the dam.According to the actual situation of the source materials of the dam site,adopting the original designed scheme is reasonable and it provides reference for engineering application.


Bidens pilosa is less widespread than the other composites commonly found in Singapore as it is animal-dispersed, as opposed to wind-dispersed like most of the Asteraceae. However, this species has been observed to spread over a large area within a year in suitable habitats of sandy or rocky moist substrate with adequate sunlight, such as Jalan Chichau and Jalan Lam Sam. Judging by its invasive success in other tropical and subtropical countries, it should do well in Singapore. More studies can be done on this species, and the populations in the abovementioned localities should be closely monitored to determine the success, and the spread of the species.


Ant colony optimization (ACO) has been widely and successfully applied to NP-hard combinatorial optimization problems for its strong searching ability and robustness. Recently, several extended ACO algorithms have also been proposed to deal with continuous optimization problems. However, the ACO algorithms always have slow convergence speed and encounter premature convergence in engineering applications. This paper proposes a novel adaptive parameter control method for continuous ACO algorithms. Clustering analysis is used to judge the optimization state of the algorithm and the flexible adjustment of the parameters is based on these optimization states during the training process. As an example, the adaptive control method is used to improve the performance of the continuous orthogonal ant colony (COAC). Experimental results demonstrate that the clustering-based adaptive parameters control scheme contributes to both faster convergence speed and higher solution accuracy. The proposed adaptive control method has great practical value and bright prospect.


In the present work, unsteady flow solved by the Reynolds time-averaged Navier–Stokes equation was investigated to determine the inflow distortion mechanism and the spatial distribution of hydraulic loss in a bidirectional axial flow pumping station (Case 1) based on the entropy production theory. A laboratory-scale performance experiment was also employed for the accuracy verification of the simulation approach, and an axial flow pump with pipe passages (Case 2) accompanying uniform inflow was utilized for analysis comparison. The results show that the non-uniform inflow causes a noticeable reduction in head and efficiency, as high as 27% and 21%, respectively, and the best efficiency point with uniform inflow shifts to the point with a larger flow rate. The axial velocity of the impeller inlet in Case 2 changes more smoothly along the Span compared with that in Case 1, which further indicates a more uniform inflow at the impeller inlet. The total entropy production (TEP) of each domain in Case 1 is always higher than that in Case 2, and the TEP of the whole domain in Case 1 increased by 18.68%, 30.50%, and 29.67% with flow rates of 0.8Qdes, 1.0Qdes, and 1.2Qdes, respectively, compared with that in Case 2. In the inlet passage, the larger TEPR regions in Case 1 are mainly located in the horn passage, which is far away from the inlet side, and are also distributed in the suction side of impeller blades and guide vanes. Therefore, this work may provide an optimal design reference for pumping stations in practical application.


intervention. I do not think it totally succeeds in avoiding the latter, owing to the types of approach and emphasis on particular methods (i.e. psychological inventories and questionnaires) despite its attempt to present a more integrated model. It does make a comprehensive attempt to define the difficult category of 'entrenched drug-using offenders' which I feel is a valid endeavour (many would disagree!) whether you conceive of this in behavioural terms or by other philosophies. However, whilst the book acknowledges the dilemma between generality and diversity, it does not demonstrate this in practice in its methods or examples. The last chapter goes some way towards redressing the balance by stressing the need for more holistic strategies that should accompany more specific techniques, and emphasising the need to allow for client choice and


Because cafes have become the `third place,` or informal meeting venue where people can study and rest between school or work and home, understanding the needs of the single patron as well as those visiting in groups is worthwhile. In a small and compact space in an urban setting, a larger, wider, or deeper interior space is desirable; thus strategies to achieve these conditions will benefit patrons. The researchers explored the relationship between spatial depth and patrons' intent to stay by showing 44 interior design students images of cafes as stimuli. Fifteen different conditions of cafe space were developed digitally, and participants' eye movements were measured using an eyetracker when they searched for images that looked deepest. In addition, participants were asked to select one image for alone and one for group an image from among the 15 that depicted a cafe where they would want to stay when visiting alone as well as when accompanied by others. The researchers' results show that spatial depth is more important for a user visiting alone than for one accompanied by others. The results of this exploratory study will increase understanding of the role that spatial depth may play in intent to stay with respect to the number of visitors in a cafe.


The invention discloses an electrolytic milling machine for a metal plate. The electrolytic milling machine comprises a rack, an upper electrode, a lower electrode and an electrolyte collecting tank. A workpiece supporting frame is arranged in the electrolyte collecting tank, and when an upper electrode moving frame moves, the upper electrode can be moved to the position above the workpiece supporting frame. An electrode electrolyte outlet plate cover is arranged on the upper portion of an electrode electrolyte outlet plate of the upper electrode, and a plurality of electrolyte outlet grooves are formed in the electrode electrolyte outlet plate. Inlets of the electrolyte outlet grooves are formed in the upper surface of the electrode electrolyte outlet plate and communicated with an inner cavity of the electrode electrolyte outlet plate cover, outlets of the electrolyte outlet grooves are formed in the lower surface of the electrode electrolyte outlet plate, and electrolyte inlets are connected with electrolyte inlet pipes. The lower electrode is connected with the workpiece supporting frame or located beside the workpiece supporting frame. A mother electrode plate of the lower electrode is electrically connected to a power-on face, and a sealing ring is arranged at the periphery of the power-on face. When the top face of the sealing ring bears no pressure, the top face of the sealing ring is higher than the surface of the power-on face, and a processed plate clamping device is arranged on or beside the mother electrode plate. According to the electrolytic milling machine, electrolytes can be evenly sprayed to the surface of a workpiece, and the lower electrode can be prevented from being consumed.


LARGE sums of money and much effort on the part of health educators are dedicated to the mass communication of knowledge by means of radio, television, mailed material, newspapers, magazines, and other mass media. How effective are these activities? How can they be made more successful? With the aid of a grant from the U. S. Public Health Service and with the cooperation of our Health Department, Tuberculosis and Health Association, Pharmaceutical Association, Medical Society, P.T.A., and other community groups, we have been seeking answers to these questions in San Diego. We have sought to evaluate health education activities in our area by opinionpoll and other techniques. The specific aims of our project are:


Influence of the higher modes of radiation on characteristics of a frequency reference with an external interferometer is considered. It is shown, that the higher modes can influence essentially on reference frequency shifts through the mechanism of "pulling" in case of local detection of a laser beam.


The deep forest model is a deep learning model comparable to deep learning proposed by Zhou and Feng, which has good performance in classifying small-scale datasets. The deep forest cascade part consists of multiple sets of random forests, in which decision trees with different classification strengths and different correlations between decision trees can lead to degradation of the overall model performance. To solve this problem, this paper proposes a low cohesion high coupling deep forest classifier (LCHCDF), which is an improvement on deep forest for imbalanced datasets. The algorithm prunes the forest by comparing the AUC values and inner product sums between decision trees in the forest, and aims to improve the strength of individual decision trees in deep forest while reducing the correlation of decision trees. In this paper, several experiments were conducted on the UCI dataset using Random Forest, Deep Forest, Adaboost, XGBoost, Decision Tree, and LCHCDF algorithms. The experimental results show that LCHCDF has good performance compared with other algorithms.


Summary 1. Lesions of the anterior hypothalamic area and preoptic region were associated with a definite and apparently isolated rise in blood urea, no change being noted in the level of the other blood substances tested. 2. In 3 animals surviving beyond 18 days the elevated blood urea returned to a normal level (Table I). 3. With one exception the kidneys of the operated animals were macroscopically normal. 4. No apparent interdependence was discerned between the level of blood urea and the state of severe anemia or between the former and body temperature or the development of obesity. The disturbance in the level of blood urea presumably is not associated with any discernible metabolic disorder. The rise in blood urea may be due to an impairment of the ability of the kidney to clear urea at normal blood level; an increased blood urea may be a prerequisite for the adequate elimination of this substance when lesions are made in the anterior hypothalamic and preoptic regions.


The effective tax planning by employing units makes employees' income relatively increase,which plays an important role to improve employees' motivation and coordinate the relationship between employing units and staff.From the two factors of the amount of money of tax income and tax rate,this article discusses methods that employing unit makes tax planning for the staff under the premise of law permission and net-increased benefit such as the reasonable arrangements of welfare,annual salary,year end salary increase and labor bonus.


This paper presents a cluster-based PMBK (CPMBK) multiprocessor system and analyses its performance of bandwidth. This interconnection network offers advantages such as more flexibility. Two situations are considered: (1), a processor is equally likely to address any one of the memory modules, (2), a processor has a few favourite memory modules. The results derived show that the cluster-based PMBK multiprocessor system performs well and is fairly close to a typical partial multiple bus system with K classes (PMBK) for high rates of favourite requests. The number of connections of this system is also evaluated and compared with those of other systems. It shows that the cluster-based PMBK system can reduce the network cost and complexity without significantly reducing the performance compared with those of crossbar, PPMB, PMBK and cluster-based crossbar systems.


13 Pyknosis, karyorrhexis and karyolysis, harbingers of programmed cell death in many 14 systems, appear to be driving forces that transform Ishikawa monolayer epithelial 15 cells into differentiated dome cells. The heterochromatin affected by these process is 16 contained in multiple nuclei aggregated in the syncytia that form when Ishikawa 17 monolayers are stimulated to differentiate (Fleming, 2016a). The nuclear aggregates 18 are enveloped in a double membrane staining for the endogenous biotin in 19 mitochondrial carboxylases. The structure called a mitonucleon becomes vacuolated, 20 along with the heterochromatin it envelops, and this structure elevates with the 21 apical membrane of the syncytium 6 to 8 hours into the 20 hour differentiation, 22 becoming increasingly pyknotic. This phase of the differentiation comes to an end 23 when the mitonucleon membranes are breached and nuclei emerging from the 24 aggregated state can be seen to fragment explosively. Fragmented DNA associates 25 with an array of microtubules, filling the large central clearing of the predome. Some 26 chromatin remains unfragmented and can be seen of the edges of the predome 27 clearing. Cell death does not occur. Instead, the fragmented DNA coalesces into an 28 irregular mass within the apical and basal membranes of the predome under which 29 fluid has been accumulating. From the chromatin sheet, nuclei emerge amitotically as 30 described in Part 3 of this series (Fleming, 2016c) 31


1) OBT7 mutant was isolated by W light-butanol tolerance from Clostridium saccharoperbutylacetonicm ATCC 13564 (N1-4 strain). The mutant produced 16.5 g/l (1.4-fold increase) of n-butanol, 4.65 g/l (1.5-fold increase) of acetone, and 21.5 g/l of total solvent. It was suggested that clostridial bacteria producing n-butanol does not have a poor effect on misrepair via an error-prone pathway by UV light-butanol tolerance. 2) Compared to glucose fermentation, in mannitol fermentation, OBT7 mutant did not produce acetone and acetic acid. And the ratios of n-butanol and ethanol to total solvents increased by 10.3% and 10.5%, respectively, totalling 20.8%, while the ratio of acetone was decreased by 21.2%. Also the maximum ratio of n-butanol to total solvents reached 94.8%. These results indicated that oxidized compound (acetone, acetic acid, and butyric acid) was converted to the reduced compounds (n-butanol, and ethanol). Therefore, mannitol can be used to eliminate by-products of oxidized compound.


Fe3O4 nano-particles were prepared successfully by electron beam(EB) irradiation at room temperature and ambient pressure and without any kind of catalysts.The component,size,morphology,optical properties and dispersion of the irradiated products were studied by X-ray diffraction(XRD),transmission electron microscopg(TEM),ultraviolet-visible spectrophotometer(UV-vis) and laser scattering particle size distribution analysis(LSPSDA).The results show that the average size of the nano-particles was estimated to be about 20 nm calculated by Scherer formula and the sizes of Fe3O4 nano-particles were ranged from 8 to 18 nm using nonidet P40,hexametaphosphate and ammoniumcitratethe as dispersive agents.


The article was erroneously published as Review article. The authors would like to change the article type to Prospective clinical research report. Please consider it as Prospective clinical research report. Journal of International Medical Research 49(5) 1 ! The Author(s) 2021 Article reuse guidelines: sagepub.com/journals-permissions DOI: 10.1177/03000605211017393 journals.sagepub.com/home/imr


The utilization of micro-electro-mechanical system (MEMS) gyros and accelerometers in low-level inertial measurement unit (IMU) influences cost effectiveness in a positive way under the condition that device error characteristics are fully calibrated. The conventional calibration process utilizes a rate table; however, this paper proposes a new method for achieving reference calibration data from the natural motion of pendulum to which the IMU undergoing calibration is attached. This concept was validated with experimental data. The pendulum angle measurements correlate extremely well with the solutions acquired from the pendulum equation of motion. The calibration data were computed using the regression method. The whole process was validated by comparing the measurement from the 6 sensor components with the measurements reconstructed using the identified calibration data.


Architecure+Function+Energy efficiency Is it possible to combine modern architecture with sustainable development? If it is possible how do you combine these parameters? That is where my project has its focus. The house is a one family villa and it is placed on the country side in Bjarehalvon, a peninsula in northwest of Skane, inspired by the existing architecture in the area as well as modern buildnings. I have tried to combine this modern home with energy efficiency to show people that ecological houses doesn?t have to be boring. It is important that we try to minimize our effect on our environment and if we can build a house just as good as any, that uses half or even less energy than the average building, why don?t we? The knowledge is already here so why don´t we use it? (Less)


Providing a consistent and adequate supply of nutrients is an important factor in optimizing health and production of dairy cattle. The tota l mixed ration (TMR) feeding system is widely utilized as a tool to provide a consisten t supply of nutrients; however nutrient variability is still a concern. The objectiv e of this study was to quantify variation of TMRs on six Pennsylvania dairies that utilize feed man agement software (TMR Tracker, Digi-Star LLC, Fort Atkinson WI). Herd size averaged 648 ± 405 cows with an average production of 33 ± 2.4 kg/d. Twelve weekly samples f rom sixteen different rations were collected from May through July 2007. Acros s all ration analysis, on a DM basis, CP averaged 16.49 ± 1.3 percent CP, ADF was 22.34 ± 2.14 pe rcent, NDF was 33.7 ± 2.83 percent and P was 0.369 ± 0.044 percent. For twelve ra tions on five farms the nutrient deviation (formulated nutrient profile – samp le analysis) was tested using paired t-tests to determine if fed rations differed from sa ple analysis. Significance (P<0.05) was declared when deviation differed from zero. De viations were 1.14 percent (P<0.01) below formulation for CP, 2.97 percent (P<0.01) and 3.58 percent (P<0.01) above formulation for ADF and NDF, respectively across all rations. There was significant difference in the pattern of variation of the deviation for DM percent, NE l, and CP percent between farms. All farms had taken the initi al step to improve feeding


This paper intends to explore LU Xun's translation activities in the 1930s from the perspective of Bourdieu's sociological theory. It elaborates on his text selection and his strategy choice in particular and finds out that his unique translation practice is determined by his translation habitus and the social and cultural context in his time. And the construction of his translation habitus is closely related with his life experiences, political stand, and lofty patriotism.


Objective:To study the diagnosis results of chronic subdural hematoma(CSH)CT and MRI.Method:To retrospectively analyze40 CSH patients,25 cases did routine CT,15 cases did MRI,compare misdiagnosis and imaging findings of two methods.Result:CT examination method's misdiagnosis rate was 24.00%(6/24),significantly higher than MRI(0)(P0.05);CT examination found that medium-density,highdensity,low density,and mixed density hematoma cases,respectively were:6 cases,4 cases,6 cases and 9 cases,in which a total of 5 cases of equal density hematoma,enhancement CT showed unclear.After MRI examination,15 patients could be correct diagnosis.Conclusion:Based on scientific precision CT and MRI examination procedure for patients with CSH to check the correct diagnosis of the disease both have important reference value,but the MRI misdiagnosis rate is lower,for medium-density hematoma patients,should adopt MRI examination,it is worth to promote clinical research and application.


The W-2 experiment was conducted in the Sodium Loop Safety Facility (SLSF) in the Engineering Test Reactor (ETR) to characterize the failure response of full-length, preconditioned LMFBR fuel pins subjected to slow transient overpower (TOP) conditions. After 26.5 days of steady state oper ation at representative LMFBR fuel pin power levels, an overpower transient simulating an unprotected FFTF 5^/s reactivity insertion event was initiated. Disruptive failure of the seven pin bundle occurred at 3.2 times the nominal power level as predicted, but at an axial midplane location rather than the expected upper third level in the center pin. The objectives of the post-test examination (PTE) were to characterize the physical condition of the test assembly following the disruptive failure, and identify any specific circumstances that may have contributed to the unexpected midplane failure response. The W-2 experiment was conducted in the Sodium Loop Safety Facility (SLSF) to characterize the failure response of full-length, preconditioned LMFBR fuel 1 2 pins subjected to slow (Bi/s) unprotected transient overpower (TOP) conditions. ' Disruptive failure of the 7-pin test bundle occurred at 3.2 times the nominal power level as predicted, but at an axial midplane location rather than the ex pected upper third level in the center pin. The objectives of the post-test ex amination (PTE) were to characterize the physical condition of the test assembly following the disruptive failure, and identify any specific circumstances that may have contributed to the unexpected midplane failure response.


Investigation results of inter-influence of self-similar Internet and video traffics are shown. Shown, how self-similarity influenced on the characteristics of hybrid satellite link.


The use of the Global Positioning System (GPS) has accelerated in recent years. In its inception, GPS was used exclusively by the military for navigation. Today, with the emergence of extremely capable electronics and microprocessors, GPS has been integrated into many aspects of life. It is currently widely used by both the military and various civilian industries for applications that require navigation as well as precise timing. Some applications of GPS include ground vehicle and aircraft navigation, banking, power transmission, and agriculture. As a result, disruptions in GPS availability have the potential to disrupt many services and industries around the globe, and even threaten the safety of life. Reliable operation can be interrupted by radio frequency interference (RFI), which can come from natural and manufactured sources. This work describes new techniques to evaluate the performance of GPS receivers that may be subjected to RFI events. The example application motivating this work is Ground Based Augmentation System (GBAS) reference station receivers subjected to broadband interference, for example, from nearby use of personal privacy devices (PPDs). PPDs most commonly emit broadband interference, and GBAS ground based reference receivers have experienced tracking discontinuities as a result [Pul12]. These events can cause navigation service interruptions to aircraft on final approach. To ensure continuity of the navigation service, GBAS reference stations must be able to track GPS signals in the presence of wideband interference. The objective of this work is to develop the PLL analysis tools required to design PLLs capable of tracking through RFI events, while reducing the need for time-consuming simulations and experimental validation. Instead, simulation and experimental validation can be reserved for PLL designs which are much more likely to be successful. The techniques described in this work are valid for any GPS application xiii in which the receiver cannot tolerate cycle slips in the phase-lock loop (PLL). The methodology is directly applicable to ground-based reference receivers for differential GPS systems, as well as other ground-based receivers that require high continuity of service. It is also relevant to moving receivers, if the additional dynamic stresses on the PLL are also taken into account. The PLL discriminator output (DO) distribution is used to characterize GPS PLL tracking performance, in contrast to the phase jitter metric widely used in prior work and literature. Both the DO variance and the bias on the mean of the DO distribution are shown to be superior to the jitter metric in predicting phase-lock. And, it is shown that the bias in the DO mean is the most effective measure of cycle slip probability. Studying the discriminator output distribution also provides a means of comparing different techniques to extend PLL averaging time beyond the length of a navigation data bit, without time-consuming direct simulation and experimental validation. Experimental results are presented to validate the theoretical analysis and simulations. The observed tracking results are consistent with the theoretically predicted system performance. The DO bias is superior to the variance metric in its ability to predict loss of phase-lock.


This dissertation has investigated the process of identity construction of gay men residents of Recife's Metropolitan Area through a specific culture consumption, two international pop singers, Beyonce and Britney Spears. The people interviewed were part of fandoms from the two singers already mentioned, considered by these fans as divas. Narrative and autobiographical interviews were conducted in order to identify elements of the culture identity of these fans, as well as ethnographies in social spaces of the fandoms.. It was identified a strong religious-like relationship between the fans and their divas, very similar to the most elementary religious practices Rituals, a strict division between the sacred and the profane, a conversion process into a fan, ecstasy situations and possessions characterize these religious-like practices. The research points out two central questions: a) a legitimized conception of the singers as someone divine, through the worship and utilization of consumption as a religious practice and b) the perception of a gay identity construction based in images and speeches presented by the singers. The process of "coming out of the closet" and of empowerment to gay men who consumed the singers present interconnections with the consuming practices, such as the perceptions of the respective singers as a moral source and, consequently, a role model.


The aim of this study was to observe the frequency of metabolic syndrome and its' various components in patients with ischemic stroke. This descriptive case study was conducted in Liaquat University Medical and Health Sciences hospital Hyderabad, Pakistan from June 2008 to November 2009. The study included 357 consecutive patients of either sex, presenting with ischemic stroke. Stroke was defined as a focal neurological disorder with rapid onset, which persisted at least 24 h or until death and had a brain Computerised tomography (CT) that showed a compatible low-density lesion. Patients were diagnosed as metabolic syndrome on the basis of ATPIII criteria which include the presence of at least three features: 1) blood pressure of at least 130/85 mmHg or treated hypertension, 2) serum triglyceride level of at least 150 mg/dl (1.7 mmol/l), 3) HDL cholesterol of 100 mg/dl (5.6 mmol/l) or previously diagnosed with type 2 diabetes and 5) central obesity, waist circumference greater than 90 cm in men and 80 cm in women according to the ethnic criteria for Asians. Continuous variables were expressed as range, and categorical variables as frequency and percentage. The chi-square test was applied to compare categorical variables with ischemic stroke. A p-value of 0.05 was considered as statistically significant. All calculations were done using SPSS version 16 (Chicago, IL, USA). This study included 357 patients of which 131 (36.7%) were male and 226 (63.3%) were female. The age of the patients range was from 35 to 95 years. The three components of metabolic syndrome were present in 165 (46.2%) patients, of which 41 (24.8%) were male and 124 (75.2%) were female. A strong association was found between waist circumference and low HDL. Metabolic syndrome is a frequent occurrence in patients with ischemic stroke. Key words:


The dominant treatment methods for male sexual dysfunction are currently biomedical and pharmacological. Historical analysis of the therapeutic field, however, shows that this trend is quite recent. This paper provides a historical examination of the treatment of male sexual dysfunction, analyzing the role of psychology and psychoanalysis in the treatment field. At various points in history, sexual therapies have accounted for the biological, psychological and social factors of male sexual dysfunction; this attention, however, has rarely been balanced. By tracing the evolution of treatment models, this paper shows how psychological and psychoanalytic principles have influenced the treatment of male sexual dysfunction. Despite the recent dominance of cognitive behavioral and biomedical techniques, the paper concludes, sex therapy is a discipline in flux, and with the increased push for integrative and multi-modal treatment models, the (re-)introduction of psychodynamic techniques in mainstream sex therapy is a promising possibility for future clinical practice. Copyright © 2012 John Wiley & Sons, Ltd.


Starting from the definition of the science,the authors analyze the various existent classifications of science currently.By discussing the content,basis,purpose,meaning and trend of the classification of science in six dimensions in detail,the authors try to reveal the internal relations of these classifications of science and know the overall structure of the science.It will be of great benefit to us to understand the science,promoting the unity of science and predicting the future trends of science.One-dimension science answers the question of 'what is science',two-dimension sciences include little and big science,soft and hard science as well as pure and implied science,three-dimension sciences are usually natural science,social science and literae humaniores,four-dimension sciences are the above three one and interdisciplinary,five-dimension sciences are formal science,natural science,technological science,social science and humanity,six-dimension sciences includes philosophy,symbol science,natural science,social science,spirit science and cultural science.


The objectives of the study were to determine the profitability, comparative and competitive advantages, and to analyze the impact of government policies on the competitiveness of maize, rice and cocoa farming in Gorontalo Province, Indonesia. The study was conducted in 5 districts on 2019. The Policy Analysis Matrix (PAM) was used. Maize, rice and cocoa farming in Gorontalo was profitable and feasible to implement; based on the value of private profitability and social profitability and the value of RC-ratio. Maize, rice and cocoa farming in Gorontalo had a competitive advantage of 0.74, 0.58 and 0.31 respectively. Maize, lowland rice and cocoa commodities had comparative advantages of 0.5, 0.5 and 0.27 respectively. The results of the PAM analysis showed that regional policies on the three commodities were a disincentive to output. To increase the competitiveness of maize, rice and cocoa farming in Gorontalo, it is necessary to control the output price at the farmer level; so that prices are not manipulated by collectors and the price received is in accordance with the government purchase price. This imply the need to increase technical efficiency, allocative efficiency, and improve the quality of results through intensive application, technology assistance and counseling.


In order to compile a "Catalogue of neophytes in Belgium (1800-2005)" collections of vascular plants in the main Belgian herbaria (public as well as private) were thoroughly revised. This revision considerably enlarged the current knowledge of the alien flora of Belgium and yield ed numerous additional taxa. On the other hand it has been shown that in the "Nouvelle Flore de la Belgique, du G.-D. de Luxembourg, du nord de la France et des regions voisines" a number of non-native vascular plants have been erroneously or doubtfully listed as having occurred sponta neously in Belgium. The present paper provides information on 30 non-native taxa that need to be omitted from future editions of the Flora of Belgium due to reidentification of herbarium collections. Furthermore several dubious records of non-native plants in Belgium have never been confirmed by herbarium collections and are therefore doubtful; they are listed here but have been omitted from the "Catalogue." Finally, some non-native taxa included in the "Nouvelle Flore..." have indeed been recorded for the neighbouring territories covered by this Flora, but never for Belgium and therefore they were omitted from the "Catalogue." The importance of a thorough herbarium revi sion as the main basis for the compilation of a catalogue of non-native plants (in stead of literature data) is stressed. Such a revision surely is more time-consuming but, above all, much more accurate and reliable. As such, it yielded 20% additional taxa in the final catalogue. Inversely, almost 3% of the taxa of the original list of Belgian xenophytes needed to be omitted.


Primary hyperparathyroidism (PHPT) is caused by excessive autonomous secretion of parathormone (PTH), usually as a result of a parathyroid adenoma (80-85%), and less frequently due to parathyroid gland hyperplasia (15%-20%) or carcinoma (1%) (Kaplan et al.1991). Patients often suffer from mild subjective symptoms such as weakness and tiredness, but if untreated, symptoms progess to include dementia, depression, peptic ulcer disease, pancreatitis, constipation, renal calculi, and diffuse bone and joint pain (Clark 2003).


The microbiological factor, in its different forms, is found to be enriched and effective throughout the stratified hydrochemical profile of the orefield, below the ground water table, in extraction of stable Cu-organic compounds from bituminous carbonate rocks, in liberation of Cu from such compounds in solution, and in precipitation of Cu as sulfide by the continuously evolving biogenic H2S.


The development of 'indicators' and associated techniques for the appraisal of 'sustainability' requires efforts to systematically define, quantify and aggregate many disparate dimensions of social, environmental and economic performance. This necessarily raises a number of serious theoretical and methodological difficulties, including those relating to the selection and framing of 'problems' and 'options', the treatment of deep uncertainties and the 'impossibility' of aggregating in analysis the divergent social interests and value judgements which govern the prioritisation of the different dimensions of 'sustainability'. After exploring the depth .and scope of some of these difficulties, this paper argues that they render futile any attempt to develop an 'analytical fix' for the problems of appraisal. In this light, systematic public participation is recognised not just as an issue of political efficacy and legitimacy, but also as a fundamental matter of analytical rigour. However, it is also concluded that once aspirations to the 'analytical fix' are renounced, there is much that might be contributed by transparent, straightfonvard quantitative analytical tools and the paper ends with some recommendations and an example in this regard.


PURPOSE: A method for manufacturing an organic light emitting display device is provided to form a polycrystal silicon layer with uniform crystal grain by removing the deviation of a property between a single irradiation area and a double irradiation area. CONSTITUTION: A buffer layer is formed on a substrate body. An amorphous silicon layer is formed on the buffer layer(S101). A micro crystal silicon layer is formed by thermally processing an amorphous silicon layer(S102). A polycrystal silicon layer is formed by scanning linear laser beams to be overlapped on the micro crystal silicon layer in a width direction twice or more times(S103).


Dynamic models of paradigm change can elucidate how the simplest of processes may lead to unexpected outcomes, and thereby can reveal new potential explanations for observed linguistic phenomena. Ackerman&Malouf (2015) present a model in which inflectional systems reduce in disorder through the action of an attraction-only dynamic, in which lexemes only ever grow more similar to one another over time. Here we emphasise that: (1) Attraction-only models cannot evolve the structured diversity which characterises true inflectional systems, because they inevitably remove all variation; and (2) Models with both attraction and repulsion enable the emergence of systems that are strikingly reminiscent of morphomic structure such as inflection classes. Thus, just one small ingredient -- change based on dissimilarity -- separates models that tend inexorably to uniformity, and which therefore are implausible for inflectional morphology, from those which evolve stable, morphome-like structure. These models have the potential to alter how we attempt to account for morphological complexity.


According to biological mechanism of activated sludge processes and the characteristics of cellular automata,a cellular automata model for a sequencing batch reactor was constructed.Simulations were made with practical parameters.The results indicate that the model replicates adsorption and biodegradation of organic matter,and simulates the growth,reproduction and death of microorganism.Therefore,it well describes the removal of organic matter and the growth of activated sludge.The model simulates activated sludge processes visually during reaction time,as a basis for the control.At last,the applications of this model were analyzed.


In order to confirm the assignment of the Raman active internal modes of K2SO4 and structurally related crystals, the Raman spectra of oriented cyrstals have been recorded. Using the relative integrated intensities of the bands as data, the transferability of the Raman tensors of the free SO ion to the crystals was investigated with, in general, good agreement between the calculated and measured intensity distribution. A linear dependence between the frequencies of the internal modes of the K2SO4, Rb2SO4 and Cs2SO4 crystals and the electronegativity of the cations could be observed. Also, a brief discussion about the nature of the lattice modes of these crystals is included.


The distinction between 'Lithuanians' and 'foreigners' made by the law of the Grand Duchy of Lithuania with regard to eligibility for senior offices was less clear in practice. The protracted dispute, between 1591 and 1600, over the royal nomination of a 'Pole' as bishop of Vilna, has traditionally been presented as an expression of Lithuanian particularism after the 1569 union between Lithuania and the Kingdom of Poland. Using neglected capitular sources, this article re-examines the crucial, but underappreciated role played by the Vilna cathedral chapter in this cause célèbre. The motives for the chapter's opposition to the royal nominee cast doubt on the allegedly overwhelming importance of the defence of Lithuanian 'sovereignty'. Instead, the case demonstrates the significance of material interests in the actions of early modern ecclesiastical corporations.


This Data set shows project focuses for high erosion areas along several Austin streams, including Waller Creek. These high priority sites are matched with reach scores and the status of their respective recovery plan.


This paper studies Friedrich Nietzche's influence in Uruguay during the years 1900-1920. The first part examinates the role of cultural magazines in the dissemination of his work; the second part is devoted to Nietzsche's reception in intellectual circles: How was Nietzsche read? Who read his works? Why did they read him? Historiographical reconstruction shows that Nietzsche's contribution has inspired largely the Uruguayan thought.


Abstract Impressive megabreccia levels that were deposited mainly on by-pass, steep margins of carbonate platforms have usually been linked to syn-sedimentary tectonics and, more recently, to other mechanisms including sea-level low-stands. The Apulia Carbonate Platform, a main palaeogeographic domain of the Mediterranean Tethys, is characterized by huge megabreccia bodies which were deposited along its flank at various intervals during the Cretaceous. This paper deals with the stratigraphy and the genetic meaning of a peculiar early Cretaceous megabreccia level occurring on the Apulia platform margin exposed in the southern Gargano Promontory (southern Italy). The stratigraphic implications of the megabreccias within the tectonic evolution of the Apulia platform are also discussed along with a comparison with previous models. A sub-vertical blind contact separates a tectonized Berriasian shallow-water succession (Lower S. Giovanni Rotondo Limestones) from a thick rock-fall megabreccia succession pertaining to the Late Aptian–Albian Posta Manganaro Megabreccias. The contact, which is interpreted as a syn-sedimentary fault plane, is sealed by undeformed late Albian slope bioclastic sediments (lower Monte S. Angelo Rudist Limestones). Tensile tectonics downfaulted an external sector of the platform generating an articulated, steep, retreating margin. Field analysis and stratigraphic reconstructions show that the syn-tectonic wedge-shaped megabreccias partly filled an asymmetric depocenter (half-graben) resulting from the activity of a normal fault system located behind the previous prograding, low-energy, leeward margin (Montagna degli Angeli Limestones). Nevertheless, syn-sedimentary tectonics severely conditioned the composition, depositional processes and dispersal pattern of sediments supplied towards the original platform-to-basin transition (Upper Mattinata Bioclastic Limestones). This stratigraphic framework is believed to reflect a local response of the sedimentation to a late Early Cretaceous syn-sedimentary tectonic phase representing an important turning point in the evolution of the Apulia Carbonate Platform. It is supposed here that the observed tectonics, which are assumed to be related to the onset of the Austrian orogenic phase at the distant Adria plate margin, could only control the extension of the down-faulted platform. More probably, its drowning was decisively caused by the coeval global-scale Selli palaeoceanographic event (OAE 1a), which reduced the healing power of the platform by poisoning the shallow-water, sediment-donor communities. As a major causal mechanism, the OAE Selli event controlled the development of a rapid facies evolution during the late Early Aptian within the shallow-water successions of the Apulia and many other Tethyan carbonate platforms through the onset of nutrient-enriched water conditions. In this light, a stratigraphic correlation between the bases of the late Early Aptian shallow-water Orbitolina Level and the basinal Fucoid Marls is proposed. Their deposition within distinctive tracts of many platform-to-basin transitions on the southern Tethyan margin is viewed as the response of a previously pure carbonate sedimentation to the onset of environmental control on a global scale during the late Early Aptian.


In this paper, the nonconforming mortar finite element with a class of meshes is studied without considering the global regularity condition or quasi-uniformly assumption. Meanwhile, the superclose result coincides with conventional methods is obtained by means of integral identities techniques.


In arid and semiarid areas, the issues of water security, ecological security, and food security are tightly interlinked. Understanding the water‐ecosystem‐agriculture (WEA) nexus in such areas is critical to their sustainable development. This study presents a basin‐scale integrated ecohydrological model and a paradigm for analyzing the WEA nexus through physically based modeling. The integrated model is successfully applied to the Heihe River Basin (HRB), the second largest endorheic river basin in China. A system analysis of the WEA nexus in the HRB is performed using the validated model. The major findings are as follows. First, reducing the amount of irrigation water applied to the midstream of the HRB produces widely varying effects on the water balance of the basin. Second, a threshold of 11.5 × 108 m3/yr is found for the streamflow from the midstream region to the downstream region, beyond which the contribution of the streamflow to the recovery of vegetation is trivial in the short term. Third, the trade‐off among water conservation, ecosystem protection, and food production in the HRB is strong, and it is highly sensitive to the water management strategy employed. Evaporative water‐saving practices are more desirable than direct water‐saving regulation of irrigation water from the perspective of the WEA nexus. Overall, the results of the study provide insights into the allocation of water resources, ecosystem conservation, and agricultural development in the vast arid and semiarid areas of the world.


As a harmonious society is an ideal model and value pursuit when building socialism with Chinese characteristics in the new era,the development and improvement of human nature is the core content.Taking the theory of human nature as the cut-in point and based on the clarification of the traditional theory of human nature both in the West and China,the paper has made an in-depth analysis on the human nature coordinates construction of the harmonious society from three dimensions involving material civilization,political civilization and spiritual civilization.Finally,with the realization of the human value of the harmonious society as the end-result,it discusses step by step the practice basis,self-development,basic path and final objective of the harmonious society from three layers containing the people-oriented principle,self-development and perfection of the human nature and the overall development of the people.


Our understanding of the factors controlling the preparation of sty rene-based latex products has recently undergone extensive revision. Brief ly, we have found that, under a wide range of conditions, the growing latex particles possess a core-shell structure in which a monomer-rich shell encapsulates a polymer-rich core. This two-phase behavior is remarkable inasmuch as styrene and polystyrene are ordinarily (in macroscopic sys tems) completely miscible in all proportions. The proposed core-shell mor phology explains the extended constant-rate behavior observed in styrene emulsion polymerization and permits extension of the Smith-Ewart The ory to conversions as high as 60%. In seed growth experiments, the added monomer actually encapsulates the original seed particles, up to their equi librium saturation content, thereby indicating that the phenomenon of interest is controlled by thermodynamic factors. We believe that encapsu lation is governed by the microscopic nature of the latex particles which has, in turn, a profound effect upon the conformational behavior of the long-chain polymer molecules as they interact with the particle-water in terface. These findings have important fundamental implications and tech nological applications in latex product design that are only beginning to be explored.


Multimodel deep learning system has attracted more and more attention. The traditional deep learning system mostly focuses on single modal processing and application. However, many applications require various modes to complete a certain task. For example, in the teaching scene, teaching materials are mostly displayed in text mode, video and PPT modes are also used to transfer the content of knowledge points. However, there is often a lack of connection between one mode and another mode, resulting in the fragmentation, complexity and redundancy of knowledge. Based on this consideration, the paper puts forward the design idea and frame of multimodal curriculum knowledge graph based on paddleOCR and DeepKE. Use DeepKE to extract the triple relationship between subject knowledge points and store it in the neo4j graph database, so as to build the knowledge graph of subject knowledge points, then use paddeOCR to identify the text content in the teaching video, generate the video frame description text, use NLP processing technologies such as text similarity to realize the understanding of video segments, and finally link the fine-grained video segments to the text knowledge graph, so as to build the multi-modal curriculum knowledge graph, In order to realize the purpose of intelligent search and intelligent construction of learning link.


Editor – We read with great interest the article by Barber et al. regarding the teaching of undergraduate medical students in general practice and the use of the communities of practice theory as a concept in this context. It was intriguing that both the general practitioners (GPs) who were interviewed for the study and the authors of the paper described clinical care and medical education as distinct entities. However, in our experience as medical students at King's College London we have found them to be congruous with one another.


We have demonstrated that the infiltration of temperature-responsive polymers (e.g., PNIPAAm) into vertically-aligned carbon nanotube forests created synergetic effects, which provided the basis for the development of smart nanocomposite films with temperature-induced self-cleaning and/or controlled release capabilities.


Ford and colleagues' summary of the current management of ulcerative colitis highlights the major failings of chronic disease management in the current purchaser-provider split NHS; this will only get worse with the upcoming changes.1

They rightly highlight the importance of preventing opportunistic infections with immunisations. …


A case of intracerebral pneumocephalus due to head iaj'ury is reported and reports of this rare state are reviewed. These cases are relatively rare and only 13 cases including the present case have been reported to date. In this case, magnetic re$onance imaging (MRI) clearly demonstrated not only the aecumulation of air but also the hemiation of brain tissue through fracture into the frontal sinus. Surgery for repairing the skull base fracture ]ed to successfu1 recovery without complications such as meningitis or delayed brain abscess. The diagnostic evaluations and surgical treatments of these cases are discussed. (Received July 5, 2001 ; accepted October 18. 2001)


This study investigated the commercialisation of initiation schools. It is argued that the economic hardships and lack of employment have led to some people resorting to any way of living merely for financial gain. The specific objectives were to determine and assess the regulations that govern the opening and running of initiation schools and to determine the palliatives that can curb commercialisation of initiation schools. The research was based on sociocultural theory and used a qualitative research design. The data collection methods used included secondary sources, focus group discussions and face-to-face interviews. The outcomes were that initiation schools are open to abuse by opportunistic unemployed people and some who are employed who want to add to their meagre wages so as to make a living, thereby crippling and undermining a cultural practice that is highly esteemed. The study recommends effective indigenous knowledge management to curb the unethical practices of commercialisation of initiation schools. Furthermore, strategies should be adopted to document this knowledge and formulate policies that will govern it. Contribution: In line with the journal scope, this article focuses on the African Tradition Religion practice of initiation schools. This subject matter is multi-disciplinary and it covers how the sacred practice has been defiled through commersialisation and deviation from its original intent.


The article deals with the psychological and social aspects of the Soviet «Newspeak» from the positions of the typology of speech forms. Widely used methodology of linguistics, General theory of information, psychology, theory of culture. The author reveals the main speech principles that reflect the mentality of the totalitarian culture. Among them the independent semantic sphere «отрицаемого» and «recognised», the existence of several levels of assessment («condemnatory, incentive and neutral»), euphemisms and paraphrases, contributing in language practice element «taboo». Word of the neutral group (neotsenochnye) are cleared from the "undesirable" values by splitting their semantics on the basis of polarization. Specificity of Soviet rhetoric lies in the dominance of the emotional aspect of the logical. The article carried the analogy between the Newspeak as "masking language" and language universaliyamy other totalitarian regimes. Analyzed speech contexts of totalitarian thinking, specifies the specificity of the «language person» in history.


Abstract:The efficacy and benefits of Pulmonary Rehabilitation (PR) programs is clear, particularly for chronic obstructive pulmonary disease (COPD) patients, and the consequent reduction in health care costs is evident. However, findings indicate that the implementation of such therapy still has a


Recently, we reported ab initio quartic force fields (QFFs) for the cyclic and linear forms of the C3H3+ molecular cation, referred to as c-C3H3+ and l-C3H3+. These were computed using high levels of theory. Specifically the singles and doubles coupled-cluster method that includes a perturbational estimate of connected triple excitations, CCSD(T), was used in conjunction with extrapolation to the one-particle basis set limit, and corrections for scalar relativity and core correlation were included. In the present study, we use these QFFs to compute highly accurate fundamental vibrational frequencies and other spectroscopic constants for the c-13CC2H3+, c-C3H2D+, c-13CC2H2D+ isotoplogues of c-C3H3+, and the H2CCCD+, HDCCCH+, H213CCCH+, H2C13CCH+, and H2CC13CH+ isotopologues of l-C3H3+. Improvements in ab intitio methods have now made it possible to identify small molecules in an astronomical observation without the aid of high-resolution experimental data. We also report dipole moment values and show that the above-mentioned cyclic isotopologues have values of 0.094, 0.225, and 0.312 D, respectively, while the l-C3H3+ isotopologues have values that range between 0.325 and 0.811 D. Thus, it is hoped that the highly accurate spectroscopic constants and data provided herein for the 13C and deuterium isotopologues of the cyclic and linear forms of C3H3+ will enable their identification in astronomical observations from the Herschel Space Observatory, the Stratospheric Observatory for Infrared Astronomy, the Atacama Large Millimeter Array, and in the future, the James Webb Space Telescope.


The ethical teachings and juridical principles of Islam – especially with regard to the dignity of humans and the need to protect it under all circumstances – coupled with the personal example and directives of Prophet Muhammad concerning asylum and the treatment of refugees, led to the development in Islamic civilization of a comprehensive and highly sophisticated system of ethical values and legal rules in the context of which the granting of asylum and the protection of both migrants and refugees have been universally and unequivocally regarded as moral and legal obligations, not only by states and governments, but also by individuals and civil society. In this article, it is hoped that the nature and structure of these teachings and principles are clearly, if briefly, explained. Aspects of the practical application of these norms and principles in history are also highlighted.


Mathematical analysis on the existence of eigenvalues is essential because it is equivalent to the occurrence of localization, which is an exceptionally crucial property of quantum walks. We construct the method for the eigenvalue problem via the transfer matrix for space-inhomogeneous n-state quantum walks in one dimension with n − 2 self-loops, which is an extension of the technique in a previous study (Quantum Inf. Process 20(5), 2021). This method reveals the necessary and sufficient condition for the eigenvalue problem of a two-phase three-state quantum walk with one defect whose time evolution varies in the negative part, positive part, and at the origin.


This paper presents the results obtained so far in a long term project developed in Mexico with the purpose of studying in depth students' constructions when they study Linear Algebra at the university level. The goals of the project consist in developing theoretical analyses about the constructions involved in the learning of the different Linear Algebra concepts using APOS theory; validating those analysis by means of empirical research focusing on specific concepts and relationships between them; and making didactic suggestions that can contribute to the teaching of this subject. In particular we present in this study the results obtained for the following concepts: vector space, linear transformation, basis and systems of linear equations. RESUMO Neste trabalho se apresentam os resultados de um projeto de longa duracao no Mexico cujo proposito consiste em aprofundar na forma em que os estudantes universitarios aprendem a algebra linear. Para tanto se definem como metas do projeto proporcionar uma analise teorica das construcoes envolvidas


The 1971 reprint was reviewed by David Wilson in the 1973 SAGA BOOK (vol. xviii pr. 4 pp 397-398) and in his brief review of the book, Wilson writes "I fail to see any real justification for the new edition in view of the vast amount of work on the subject produced in recent years ..." Whilst I agree with much of David Wilson's criticism of this book I do however believe that THE VIKING SHIPS is still a "stimulating" book and quite able to encourage a re-appraisal of the sub ject. The great value of this reprint edition is that it makes this book more obtainable than it has been in the past. The first edition to appear in English is now very difficult to get whilst the Norwegian edition is hardly likely to be of much use to the average student.


A simple and robust method for the detection of nucleic acids of human papilloma virus (HPV) has been developed. The assay exploits the excellent sensitivity and specificity of nested polymerase chain reaction (nPCR) that is designed in the original single tube configuration to effectively prevent the carry-over contamination. This approach theoretically covers the amplification of all cancer developing genotypes currently known. The nPCR, paired with very simple nucleic acids isolation steps, is a real alternative to the standard method. This manuscript shows its capacity for routine use under clinical conditions. It is shown that the strategy is at least as sensitive as the standard two tube nPCR and the data are acceptably reproducible.


Traditionally, the greatest concerns associated with gasoline releases have been non-aqueous phase liquids (NAPL) and dissolved-phase benzene, toluene, ethylbenzene, and xylenes (BTEX). The assessment techniques commonly used by industry (API, 1996) were originally developed to meet regulatory requirements for NAPL and BTEX characterization. However, the chemical properties and subsurface behavior of oxygenated fuel additives are substantially different from those of BTEX or other petroleum hydrocarbons, and so a reevaluation of traditional assessment procedures was warranted. In response to this need, the American Petroleum Institute has produced a technical guidance document, MTBE Site Characterization Technical Bulletin, for the appropriate characterization of sites with subsurface releases of fuel oxygenates (API, 1999). The technical bulletin uses the principles of risk-based decision making to guide the evaluation of sites affected by MTBE or other oxygenates. The publication includes an introduction to the properties and uses of MTBE, provides guidance for conducting assessments at MTBE release sites, and reviews modern assessment tools and techniques for characterizing and monitoring MTBE in the subsurface. While the primary focus of this study is on MTBE, other fuel oxygenates are also addressed. The risk-based decision making process provides a framework for determining the objectives and scope of environmental site assessments. Sites with greater risk factors warrant the most intensive assessment of contaminant sources, pathways, and receptors. Sites with fewer risk factors warrant a more limited assessment to confirm whether sources, pathways, and receptors require further investigation or corrective action. The guidance reviews the risk factors associated with oxygenate sources, pathways, and receptors. These risk factors are used to develop an initial conceptual model and to tentatively categorize a site as high, medium, or low risk. Various assessment tasks are then conducted to verify the conceptual model, and to confirm whether further investigation or corrective action is needed. Many of these assessment tasks can take advantage of improved, cost-effective methods for rapid collection and field analysis of soil, soil-gas, and groundwater samples. API (1999) provides an overview of the expedited site assessment approach and provides a detailed guide to current direct-push assessment and monitoring tools, with emphasis on their proper use at MTBE-affected sites.


orously browse through the volumes borrowed from the "Bibliothèque de l'Hôtel de Ville" (of Rue de Lobau), pressed for time by the scholarship, saw me heading for the clerk to return mine, got up, rushed towards me, greeted me and said: "I have an extra ticket for tonight at the Salle Pleyel, the famous Katia Buniatshvili is playing Liszt; more of us are already going, some are doctors, maybe you would like to meet them...You must have heard of the legend of Franz Liszt being the father of our great Carol Davila and the countess d'Agout, a story that their son neither confirmed nor denied." I immediately accepted, the hall was on Rue du Faubourg Saint-Honoré, a mere block away from the attic where I had rented a room. A smoking being out of the question for me at the time, I just put a bow tie over my white shirt and at the time we agreed upon I entered. The hall was full to the brim. The seats were indeed grouped, mine next to my library buddy. Katia – in a low cut, bare-shouldered dress, and Andrey Boreyko – an ascending orchestra conductor schooled in Sankt Petersburg both walked on stage. The young pianist, born in Georgia and barely 25 at the time proved to be a specialist in Liszt, playing the piano virtuously and the number 2 orchestra, brilliantly. A big round of applause, a bouquet of flowers, not just a sheaf of printed paper like we see nowadays, and her compliments spoken in an impeccable French. (A long time after that, in December 2018, I had the chance to hear her again at the Athenaeum...). During the break I was introduced to the others, four of which were, indeed, doctors. We commented on the performance and exchanged cards. I remembered this moment recently, when I was offered a book on a unique subject: the history of the internship and externship in medicine, a successful form of education, taken from the French Medical School system. University professors Benone Du escu, Maria and Mircea Beuran, with an interest in the history of the profession but also paying attention to the evolution of the medical teaching system, propose to readers (Romanian Academy Publishing House, June 2020), based on both archive research and personal experience the book "The internship in Medicine and Pharmacy: part of the essence of Romanian Medicine" (125p).


Although the mechanism is unclear, it has been shown that genetically normal adult mice with a large wound form de novo morphogenesis of hair follicles in wound‐induced hair neogenesis (WIHN)(1). We focused on how tissues recognize damage signals and identified that double‐stranded RNA (dsRNA)‐mediated toll‐like receptor 3 (TLR3) activation stimulates WIHN. Here, we propose a hypothesis that TLR3 stimulates retinoic acid synthesis and signalling to allow for regeneration, suggesting that common clinical methods of facial rejuvenation in human subjects through damage (such as lasers or dermabrasion), and the use of topical retinoids reflect the same biologic pathway.


The baccalaureate work deal with problems of family in all of its breadth. It characterizes the basic functions of family, the influence of family environment to education childern and allowance bearings parents. Further it describes simultaneous family with one of parents, companionate marriage and planned parenting. It shows the position of men and women in the society and in family and tries to outline the future form of a family and its perspective.


OBJECTIVE Parathyroid hormone‐related protein (PTHrP), initially discovered as the factor responsible for the syndrome of humoral hypercalcaemia of malignancy, has also been found to be expressed in placenta, in pregnant uterus, in the fetus at many locations, and in the lactating mammary gland. This study sought to establish whether PTHrP reaches the maternal circulation when it is expressed in mammary tissue during lactation or in the maternal reproductive tract during gestation.


Abstract 4434 Background: CML has a lower incidence in China than in Western countries and appears to affect a younger population (Au, Int J Hematol 2009). In recent years, IM has become the first-line standard of care across Asia for pts with newly diagnosed CML. In a cohort of Chinese pts, >25% of evaluable pts in CP failed to achieve a CCyR with first-line IM, and response rates were significantly lower in pts with accelerated-phase (AP) or blast-phase (BP) CML (Wang, J Exp Clin Cancer Res 2010). Dasatinib is a highly potent second-generation BCR-ABL inhibitor that has established efficacy and safety in pts with CML or Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) after prior imatinib therapy. Dasatinib is approved by various regulatory authorities worldwide for first-line treatment of Philadelphia chromosome-positive (Ph+) CML in CP. Limited efficacy and safety data are available for second-generation BCR-ABL inhibitors in Chinese pts with CML or Ph+ ALL after imatinib therapy. Methods: In an open-label, single-arm phase 2 study, Chinese pts aged ≥18 years with IM resistant/intolerant CML or Ph+ ALL received dasatinib 100 mg once daily (CP) or 70 mg twice daily for AP/BP or Ph+ ALL. Bone marrow cytogenetic evaluation was performed at months 3 and 6, then every 6 months in CP pts, and was optional for pts with AP/BP or Ph+ ALL. Primary study objectives were to assess rates of major cytogenetic response (MCyR) in CP pts and complete and overall hematologic response (CHR and OHR) in pts with AP/BP or Ph+ ALL. OHR was defined as CHR, no evidence of leukemia, or return to CP. Treatment continued until disease progression or intolerable toxicity. Results: Of 140 enrolled pts, 121 pts had received ≥1 dose of dasatinib and were evaluable (59 with CP, 25 with AP, 35 with BP, and 2 with Ph+ ALL). Of pts with CML-CP or AP/BP/Ph+ ALL, 52 (88%) and 53 (85%) were IM resistant, 4 (7%) and 5 (8%) were IM intolerant, and 3 (5%) and 4 (6%) were both IM resistant and intolerant. Median time from original CML diagnosis to first dasatinib dose was 46.3 months (CP) and 50.2 months (AP/BP/Ph+ ALL). More than half of pts had received prior interferon therapy. At last follow-up, dasatinib therapy had been discontinued by 7 pts (12%) with CP and 43 pts (69%) with AP/BP/Ph+ ALL, due to disease progression or loss of response in 2% and 35%, study drug toxicity in 2% and 11%, stem-cell transplant in 0% and 5%, death in 2% and 2%, and other reasons in 7% and 16%, respectively. After a minimum of 12 months follow-up, MCyR was achieved by 30 pts with CP (51%), 10 pts with AP (40%), and 8 pts with BP/Ph+ ALL (22%). In pts with CP, median time to MCyR was 12 weeks and no patient lost MCyR. Complete cytogenetic response was achieved by 25 pts with CP (44%), 7 pts with AP (28%), and 6 pts with BP/Ph+ ALL (16%). CHR was achieved by 54 pts with CP (92%), 13 pts with AP (52%), and 6 pts (16%) with BP/Ph+ ALL. In CP pts, most (51/54) who achieved CHR did so within 2 months. Median times to CHR were 16 and 12 weeks for pts with AP and BP/Ph+ ALL, respectively. After 12 months, 3 pts in CP, 2 pts in AP, and 1 pt in BP had lost their CHR. OHR was achieved by 23 and 13 pts (92% and 35%) with AP and BP/Ph+ ALL, respectively. In safety assessments (Table), grade 3/4 cytopenia was frequent but managed by dose interruption/reduction or supportive care, with 1 pt discontinued for cytopenia. Pleural effusion of any grade occurred in 15%, 20%, and 22% of pts with CP, AP, and BP/Ph+ ALL, respectively. Grade 3/4 pleural effusion occurred in 1 pt with CML-CP (2%) and 5 pts with AP/BP/Ph+ ALL (8%). Conclusions: The current study confirms the efficacy and safety of dasatinib in Chinese pts with CML or Ph+ ALL that is resistant or intolerant to IM. Results were consistent with data from global trial populations. Disclosures: No relevant conflicts of interest to declare.


The family Ptychopteridae is recorded for the first time from Tunisia. Ptychoptera peusi Joost, 1974 is new for the fauna of Turkey, and Ptychoptera delmastroi Zwick & starý, 2003 is new for North Africa including Tunisia. New finds of Ptychoptera albimana (Fabricius, 1787) are reported from France, Italy and Turkey, and of Ptychoptera lacustris Meigen, 1830 from Italy, Bulgaria and Turkey. The female of Ptychoptera delmastroi is described and its terminalia are figured.


In this paper, a new fourth-order memristive chaotic system is constructed on the basis of Chua's circuit. Chaotic behaviors are verified through a series of dynamical analyses, including Lyapunov ...


In order to study the drought resistance mechanism of Poa pratensis L.,taking Heilongjiang native Poa pratensis L.Blacktiger as material compared with the Arcadia and Eclipe which introduced from America.With the different concentrations of PEG-6000 drought condition of simulation,cell protective enzyme activity and membrane permeability change of three varieties of Poa pratensis L.under drought stress were studied.The results showed that under PEG-6000,cell protective enzyme activity of three varieties was BlacktigerEclipeArcadia.MDA and conductivity was ArcadiaEclipeBlacktiger.It showed that under the drought condition,Blacktiger plasma membrane damage was minimized,and could maintain a higher cell protective enzyme activity to reduce the damage of drought stress on plant cell,had higher drought resistance capability.


The authors present a parallel merging algorithm that, on an exclusive-read exclusive-write (EREW) parallel random-access machine (PRAM) with k processors merges two sorted lists of total length n in O(n/k+log n) time and constant extra space per processor, and hence is time-space optimal for any value of k >


Introduction and objectives: Coronary bifurcation lesions are a common scenario in our interventional practice and can be challenging for our routine clinical practice. Yet despite the existence of well-defined techniques, side-branch compromise is still the most important problem. Currently, the standard strategy recommended is a 1-stent technique: balloon angioplasty and provisional stenting. Published non-randomized data reveal that in up to 26% of the cases the indication for rotational atherectomy was to preserve the side-branch. A randomized comparison between rotational atherectomy and provisional stenting (RAPS) and standard strategy (SS) for the management of bifurcation lesions is needed at this point. Methods: We conducted a single center, prospective, randomized pilot study of consecutive patients from our center with bifurcation lesions. We compared the RAPS strategy to the SS. Lesions had to be located in the main vessel only. The bifurcation lesion angle was recorded. The primary endpoint was the need for side-branch therapy. 257 J. Palazuelos et al. REC Interv Cardiol. 2020;2(4):256-263


This report provides information about modern pipe samples containing dent and cracked gouge defects for performance evaluation of inspection technologies. Five mechanical damage dent and gouge defects were created in a realistic manner in modern pipes and then submitted to internal pressure cycling to initiate a significant crack at the gouge bottom. Three types of defects were created: shallow gouge in shallow dent, severe gouge in shallow dent and shallow gouge in severe dent. All defects are planned to be used to performance evaluation of inspection technologies. These defects are similar to those created in project PRCI MD-4-1 for destructive metallurgical characterization and for burst and fatigue tests.

This version of the report contains the results of measurements of defects' dimensions, and other observations, to be held confidential, in order to allow blind testing of inspection technologies.


Word Version  December 5, 2014 TO THE
ADMINISTRATOR ADDRESSED: Subject:  2015-2016 Innovative Course Applications The Texas
Education Agency (TEA) is now accepting applications for innovative courses for
the 2015-2016 school year. The Texas Administrative Code (TAC), Section 74.27 , allow


Disclosed is a profit obtaining system through advertisement display on fixed or moving objects. Such an object may receive, store, poll and extract data to present content based on time, location, and relative movement during a day in a particular environment, wherein the mobile or mobile communication object within the environment The stored data and information can be transferred between objects or sent to a static object, and then the data and information are used to enable and control such display so that the owner of the object is compensated. The system enables display of hyper-relevant advertising content along with synchronized remote audio, personal messaging and public service alerts on nearby objects and provides real-time logging and subsequent downloading of data Verifies communication and content delivery between objects, tracks and measures consumer engagement, and verifies consumer's direct response to ad viewing using an accountability system.


A vibrating downhole tool includes a housing having a central axis defined therethrough, and inner mandrel 320 disposed within the housing configured to receive a drilling fluid. The tool further includes a number of turbine blades 322 configured to receive the drilling fluid and to rotate the inner mandrel 320, thereby causing the tool to vibrate. At least one property of one of the turbine blades 322 differs from the property of the remaining turbine blades 322. Said property may be size, shape, mass or profile.


A calculation method has been developed to enhance the effect of deuterium labeling in the mass spectra of linear vicinal dideuterioalkanes (LVDA). Individual LVDA can be identified from these enhanced spectra. Single carbon-number mixtures of LVD nonanes and LVD decanes have been analyzed successfully using matrices derived from spectra of standards. In addition, enhanced mass spectra have been predicted for all of the LVD heptadecanes and LVD nonadecanes. Matrices have been constructed from the predicted spectra, and preliminary tests of these matrices have been conducted. All identifications and analytical results on the LVDA studied can be used to identify the precursor olefins.


Objective
To explore expression of microRNA (miRNA, miR)-221 and its related mechanisms in rats with acute myocardial infarction (AMI).

Methods
AMI model was established by ligation of left anterior descending branch of coronary artery. Thirty-six AMI rats successfully established were randomly divided into AMI group, control group and inhibition group with 12 rats in each group. The control group and inhibition group was injected with green fluorescent protein (GFP) lentiviral vector miR-221 negative control (NC) and miR-221 inhibitor by local injection of myocardial tissue transfection, respectively. AMI group and sham operation group were given normal saline. The expression of miR-221, Apoptosis index (AI) in myocardium, The activity of aspartic proteinase (Caspase)-3 and Caspase-9, the expression of B lymphocytes -2 (bcl-2), bcl-2 associated X protein (bax), cyclin dependent protein kinase phosphatase signaling pathway activation was detected.

Results
Compared with AMI group and control group, AI (t=5.874, P<0.01), the activity of Caspase-3 (t=6.219, P<0.01), Caspase-9 (t=5.942, P<0.01) and the expression of bax (t=8.512, P<0.01), p27 (t=5.878, P<0.01), p57 (t=11.244, P<0.01), phosphatase and tensin homolog deleted on chromosome ten (PTEN, t=6.063, P<0.01) was decreased, the expression of bcl-2 (t=5.971, P<0.01) and p-Akt (t=9.140, P<0.01) was increased in inhibition group (P<0.01).

Conclusion
Down-expression of miR-221 could significantly inhibit AMI rat' myocardial injury, which related to regulation of PTEN/Akt signal pathway.

Key words:
MicroRNA-221; Acute myocardial infarction; Rats; Myocardial injury