The invention discloses a bridge structure monitoring system based on WSNs and multi-agent collaboration. The monitoring system is characterized by comprising a plurality of sensor bodies, information collection and data processing and transmission are carried out on a perception object in a network coverage monitoring area between the sensor bodies through the wireless sensor network and the multi-agent collaboration technology, and finally the data are sent to an upper computer monitoring center through a gateway node. The problems that a traditional bridge structure monitoring system adopts wire monitoring, a large number of cables need to be arranged, the cost is high, maintenance is inconvenient, and therefore real-time monitoring cannot be achieved are solved.


World Health Organization on Quality of Life Brief Scale(WHOQOL-BREF)was used as a tool to assess quality of life(QoL)of patient in Methadone maintenance treatment by oneself,to understand relationship of quality of life to patients of Methadone maintenance treatment and economical state.The result showed,the better economic state,the better QoL of patient.Meanwhile,it was very important to improve quality of life to patient on family supporting.


force – a ghost, a virus, a code – that harnesses "users" to execute its commands. Language, which we always knew was "saturated with ideology," is more precisely at this moment "permeated by money." The language of the news, entertainment, sports, weather, statistics, culture: here is the muted call of "the conditions." Here is "the material." In this light, we might appreciate the prescience of Mayakovsky"s remark that there are certain problems in society for which solutions can only be found in poetic terms. As a mode of language that is not confined to the trafficking of easily-consumable images and ideas, nor to its worn-out role as a conduit for the elaboration of a priestly or panoptic subjectivity (poem-asvoiceover), poetry can respond to the problems of its historical circumstance by forming a provisional "poetic front" – or perhaps a bloc – charged not with the fatigued political work of "consciousness raising" or "altering perception" (as one wry commentator has put it, "the very fact that we have heard of Roger Daltry proves we cannot develop revolutionary consciousness"), nor with the "appropriation" of a crumbling discursive machinery, but with weakening the command of the capitalist information field through the re-presentation of the empty volume of its own social facts. A writing that acknowledges its deeply material entanglement with exchange by replicating that particular transaction which every capitalist seeks to avoid: the return of used, damaged, or stolen, goods for a full refund – or, in this case – a full life. A dis-utopian un-writing – one that avoids the old traps of "moral commitment, beautiful soul, ideological militancy, etc.", in favour of "a new realism...the testimony of a desperate epoch, constructive punk realism, expressive violence shaking the techniques of mystification of communication...[a] hope incarnated by that which we know can no longer sustain it." Such a task is not "political," at least not in the conventional sense. Poets are not legislators. Writing does not have to concern itself with the distribution of epiphanies and sensibilities, nor with the prepping of a fresh citizenry in time for the next Federal election. It does not need to solve the problems that capital needs solved. In short, it does not have to help anyone "come to terms" with the world, which is always the first step in legitimizing it. Instead, poetry"s role remains primarily affective: to joyfully render the present even more intolerable than it already is, while gesturing toward new forms of affinity, agency, and association. To provide accounts without tallies. Events without examples. Means without ends, by whatever means necessary. Hic Rhodus, hic salta!


This article presents a theoretical analysis of the dependence of the exciton binding energy and exciton–LO-phonon coupling on the cylindrical quantum dot (QD) size. The effect of the temperature on the integrated photoluminescence line intensity is also investigated. Calculations were performed within the effective-mass approximation by using a variational method. Specific applications of these results are given for CdTe QDs embedded in a Cd1−xZnxTe matrix. The excitonic confinement is described by a finite, deep potential well. We observe, on the one hand, an enhancement of the exciton binding energy and the exciton–LO-phonon coupling energy with decreasing dot size. On the other hand, at high temperature, the LO phonon has a noticeable effect on the photoluminescence intensity. This last physical parameter also shows a great dependence on QD size and on the potential level induced by the barrier material.


We developed a new ochratoxin A (OTA) aptamer biosensor to promptly detect OTA in food. Mesoporous silica nanoparticles (MSN) were used as carriers, and aptamers were used as recognition probes and gating molecules. The fluorescent dye Rhodamine 6G (Rh6G) was loaded into mesoporous silica, and through electrostatic contact, the OTA aptamer was adsorbed on amino-modified mesoporous silica. The fluorescent dye released from the mesopore in the presence of OTA because of the conformational change induced in the aptamer by the target. The amount of ochratoxin was determined by measuring the fluorescence intensity. Our findings revealed a positive relationship between the fluorescence intensity and OTA concentration, with a limit of detection of 0.28 ng mL-1, and the detection range was 0.05-200 ng mL-1. The recovery rate was 80.7%-110.8% in real samples. The proposed approach is suitable for the quantification of other toxins.


Cranial ultrasonography (cUS) and MRI are the preferred modalities used to image the neonatal brain. Both have their specific contributions and advantages. A neuroimaging study, including sequential cUS and single MRI, was performed in a cohort of very preterm infants (gestational age <32 weeks). The major aims were: to study brain imaging findings and to assess the incidences of brain abnormalities and the relationship between brain abnormalities and perinatal clinical parameters; to compare cUS and MRI findings; to describe imaging findings of the thalami and basal ganglia; and to study the reliability of cUS for detection of (diffuse) white matter injury. Patients & methods: Very preterm infants, born during a 1.5-year period, were eligible if there were no exclusion criteria (i.e., metabolic and genetic disorders, or infections and/or congenital malformations of the CNS). Sequential cUS was performed from admission until discharge and on the day of the MRI following a standardized protocol. MRI (3 Tes...


This paper stresses the importance of relating antigenic properties of FMD virus, determined by serological and biochemical tests, to immuno genic properties. Factors involved in protection, other than those involving neutralisation as measured in vitro, are discussed. A generalised model for FMD virus is proposed and the implications of the topology of the antigenic sites on the binding and subsequent effects of binding of antibodies, are high lighted. Evidence to support the theoretical treatment is provided from studies using monoclonal antibodies. The use of such reagents for the identification of epitopes and the determination of biological functions associated with anti gens is discussed.


The theory of solving initial-value problems in associated spaces makes it possible to solve initial-value problems with more general initial functions. In many cases the associated space is not uniquely determined, i.e. there exist various so-called co-associated spaces in which initial-value problems can be solved. The present paper is aimed at giving an example to this fact.


We determine the zero-temperature density profile of a cloud of fermionic atoms in a trap subject to a mutual attractive interaction, as the strength of the interaction is progressively increased. We find a significant decrease of the size of the atomic cloud as it evolves from the weak-coupling regime of overlapping Cooper pairs to the strong-coupling (Bose-Einstein) regime of nonoverlapping bound-fermion pairs. Most significantly, we find a pronounced increase of the value of the density at the center of the trap (even by an order of magnitude) when evolving between the two regimes. Our results are based on a generalized Thomas-Fermi approximation for the superfluid state, which covers continuously all coupling regimes.


All too often neglected and overgrown, holy wells still dot the AA English countryside. Many more are merely a distant memory: names recorded by dead antiquarians, folklorists, and topographers and since forgotten, sites marked on Ordnance Survey maps soon to be obliterated by the encroaching urban and industrial world. Despite the heroic efforts of a group of local historians, this aspect of British heritage is in rapid decline. Those which have survived represent only a tiny fraction of the vast number that were scattered across the rural landscape on the eve of the Henrician Reformation. Wells were an integral part of the late medieval geography of the sacred, a matrix of ancient holy places where ordinary people could approach and invoke the divine. Casual weekend visits by ramblers and picnicking families are almost all that remains of the thriving culture of pilgrimage to such hallowed spots.


The importance of assessment of reverting farmland to forest and grassland is discussed in this paper. Meanwhile, the suitability assessment system of reverting farmland is established for the middle and lower reaches of Tarim River, which involves 13 assessment indexes in the 4 aspects of soil, water, climate and economy. Furthermore, the AHP is used to determine the weight of indexes. The results of the quantitative analysis can offer guidance to practise the reverting of farmland to forest and grassland in this region.


Introduction: Tuberculosis (TB) is a chronic de-bilitating infectious disease with high morbidity and mortality. The anti-TB treatment (ATT) has been associated with major adversities and non-adherence to the specified regimen is one of the main drawbacks in its management. Men-Streszczenie tal and abuse to non-adherence The aim of this study was to estimate the impact of mental disorder comorbidity and alcohol use on TB treatment in a government tertiary care centre in south India. Material and methods: A cross-sectional obser-vational study was conducted at a government centre where 110 subjects were recruited by con-venience sampling. The Modified Kuppuswamy Scale was used to obtain socio-demographic and habit data, the Alcohol Use Disorder Identification Test (AUDIT), Young Mania Rating Scale (YMRS) and Hamilton Depression Rating Scale were used for recording on the alcohol dependence, manic symptoms and associated depression levels respectively. Structured Clinical Interview for DSM Disorders was used to score on mental illness along with diagnosis reported as per ICD-10 criteria. Results: The results showed that 64 patients (58.7%) stating that alcohol consumption to be the reason for ATT non-adherence, followed by nausea ( n = 9, 8.3%), work ( n = 5, 4.6%) and feel-ing good after the intensive phase of treatment ( n = 4, 3.7%). Personality factors like anger and impulsivity were found to be highly prevalent with a positive correlation ( p < 0.005). Discussion: Alcohol dependence syndrome was found to be vital reason for anti-TB drug discontinuation following intensive phase as patients started to feel better. There was a positive correlation with AUDIT score in our study. Personality factors like vulnerability or hostility had a positive correlation with alcohol dependence. Our study replicates the results of previous studies from other part of India and other countries. Conclusions: Alcohol use was the important reason for non-adherence to ATT. Alcohol dependence therapy can be planned in such cases for better anti-TB treatment effectiveness.


We present an analysis of routing data collected from approximately 30 Internet sites from around the world. The routing data was collected using traceroute, and maintained and analyzed using a route database in Tcl. The analysis revealed several interesting pathological cases, such as unreachable destinations and traces that fluttered between different paths, that accounted for approximately 6% of the total number of attempted routes. We also calculated metrics designed to show the relative difference between two routingpaths, the relative stability of a route, and the number of routes and relative proportion of those routes from a particular source to a destination. Wealsomeasured the short-termvariance inpacket delay; results are shown to agree with earlier studies. Results show that the number of paths taken from a source to destination is relatively small, the entropy of a particular source-destination path is also small, and the difference betweendistinct paths is not extreme. The stabilitymetric indicates that 90% of the measured routes were stable for 200 hours or less before changing to a new route. We also comment on the impact of these metrics on higher-level protocols such as TCP and resource-allocating quality of service protocols.


General Objectives
This session addresses the roles of behavioral sciences in developing and
improving the quality of human life.
It highlights the application of behavioral sciences in designing suitable
interventions to humanise human for sustainable future
Specific Objectives
1. To introduce Society 5.0 as the latest type of society.
2. To discuss issues and challenges encountered by the current society
3. To deliberate the concept of Humanising Human; and its importance
4. To discuss the roles of Psychology in relation to the Sustainable
Development Goals


The article clarifies the concept of "information-educational environment" in terms of professional training of speech therapists. The author's definition of information-educational environment based on the results of the analysis of the concepts "information environment" and "educational environment". It is a synthetic systematic formation accumulating intellectual, cultural, programmatic, organizational and technical resources and involving the use of a wide range of traditional and new information technologies and their technical means aimed to education and development.


The main purpose of a small molecule compound collection that is sometimes considered to constitute the crown jewels of a drug discovery organization is to supply the discovery pipeline with hit‐to‐lead compounds for today's and the future's portfolio of drug discovery programs and to provide tool compounds for the investigation of biological targets and pathways [1–7]. Independent of the followed discovery strategy relying on diversity or hypothesis‐ based screening, the automated access to high‐quality compounds constitutes a key asset [8]. Accordingly, all major organizations, including the National Institutes of Health (NIH) and the European Union Innovative Medicines Initiative (EU IMI), have initiated over the last years dedicated compound collection enhancement projects [9]. In alignment with the general paradigm shift observed in drug discovery, going from quantity to quality, the fundamental principle aims to select both—at the chemical and the biological level—the best possible molecular starting points for lead discovery and development in the early drug discovery phases in order to reduce attrition at later preclinical and clinical stages. To be successful on the long‐term perspective, such design strategy addresses the known target space and tries to expand into nonprecedented areas of chemical and biological spaces using diversity principles [5, 6]. Directing the molecular properties toward the lead‐like space is expected to improve overall success rates. The application of absorption, distribution, metabolism, excretion, and toxicity (ADMET) property models and rules of thumb aims to reduce the attrition risk and can be front‐loaded into the design


During the late 1970's and early 1980's, petroleum resources were developed in the central Alaskan arctic coastal zone. Governmental agencies mandated to protect these biological resources required impact mitigation measures in various project designs and implementations. The agencies also required studies to determine actual project impacts and the effectiveness of the mitigation measures. The studies would presumably increase knowledge of impacts and the success of mitigation efforts. After more than a decade of development and extensive studies, agreement on impacts and mitigation still escapes agencies and industry in many areas. To a certain degree this stems from a fundamental difference in study interpretation. This lack of agreement casts serious doubts as to the validity and utility of the existing permitting and the impact mitigation process.


Current literature has not definitively demonstrated the superiority of interbody support compared with PLF alone in deformity surgery. We compared the 5-year clinical and radiographic outcomes between PLF alone and interbody support. Our study suggests that there is no absolute long-term advantage for lumbar interbody support in adult spinal deformity patients undergoing spinal arthrodesis to the pelvis. Study Design. Retrospective review of prospectively collected data. Objective. To determine if the addition of L5-S1 interbody support in long fusion deformity constructs is associated with superior long-term clinical and radiographic outcomes. To compare the 5-year clinical and radiographic outcomes and complications between long fusion constructs with L5-S1 interbody support versus posterolateral fusion (PLF) alone. Summary of Background Data. Cadaveric biomechanical studies have suggested that an interbody fusion at L5-S1 is beneficial in long fusion constructs with sacropelvic fixation. However, there is limited data reflecting the superiority of interbody support augmentation in optimizing arthrodesis and deformity correction relative to PLF alone. Methods. Eighty-eight consecutive adults with spinal deformity who underwent at minimum T11-pelvis posterior pedicle screw instrumentation with 5-year follow-up were included. Two cohorts were compared based on technique used at the lumbosacral junction (L5-S1): (A) no interbody (PLF; n = 23), or (B) interbody support at L5-S1 (IB; n = 65). Radiographic measurements and clinical outcome measures were compared at multiple time points. Complications were recorded and compared. Results. No differences in baseline patient characteristics between cohorts. One nonunion occurred at L5-S1 in the PLF group (P = 0.091). Initial postop sagittal alignment was better in the IB group (PLF: 6.46 cm, IB: 2.48 cm, P = 0.007); however, this was not maintained over long-term follow-up. No significant differences in proximal junctional kyphosis (PLF: 7/23, IB: 9/65, P = 0.076). Proximal junctional failure was more frequent in the PLF group (PLF: 6/23, IB: 6/65, P = 0.043). No significant differences in complications were found. Both cohorts had improvement from baseline pain and functional scores. Conclusion. There is no absolute long-term advantage for lumbar interbody support in adult spinal deformity patients undergoing spinal arthrodesis to the pelvis. Level of Evidence: 3


Low cycle fatigue tests with full-scale structural specimens have been carried out in the Ship Structures Laboratory at Delft on a 600 ton tension-compression machine. The specimens represented the interconnection of longitudinal frames and transverse bulkheads constructed in a higher strength steel. Six specimens were of the interrupted type; four ones had a continuous bulbframe. A comparison is made with similar bottom longitudinals made of mild steel. Axial cyclic loading was applied ( Pmin/Pmax = - 1/2 ). The results are given for different crack areas as a function of nominal, local and peak stresses.


This study aims at improving the service standard of the Chinese national freeway control system with fuzzy logic theory. The uncertain features of the freeway system are first considered. Then, a kind of multi-level fuzzy decision-making architecture, suitable for a large complicated system, is proposed, to act as the main control strategy. The fuzzy decision-making mechanisms of three major freeway control methods based on this kind of architecture are discussed in detail. The implementation of the fuzzy decision-making on the existing hierarchical computer surveillance system is finally probed.<<ETX>>


Non-adherence to prescribed medications has been the focus of much interest in the literature owing to the poor treatment outcomes and increased healthcare burden which ensue as a consequence. In order to develop targeted interventions to address treatment non-adherence, it is necessary to first understand the factors which may influence patients' medication taking behaviour. It has been suggested that patient gender may be one such factor, where knowledge of its impact can have the potential to assist researchers and clinicians in pre-empting instances of non-adherence and allowing them to monitor patients more closely and intervene in a timely fashion if required. In this article, we explore the issue of gender and nonadherence by examining the findings of studies related to three key disease states. It is apparent that there are variations in research evidence on this topic and that it is likely that other factors such as regimen complexity and patient knowledge interplay and may also demonstrate a larger role in impacting adherence to therapy.


The Wyoming Rural Road Safety Program (WRRSP) was developed to help counties identify high-risk rural roadways and develop a strategy to obtain funding to reduce crashes on the riskiest segments. The WRRSP developed a 5-step procedure for improving the safety of rural roads in Wyoming. A county that completes the 5-step procedure has assembled the information necessary for developing a plan to fund safety improvements under the High-Risk Rural Road Program or through other sources of funding. The Mountain-Plains Consortium and the Wyoming Department of Transportation are facilitating statewide implementation of the WRRSP. The University of Wyoming is providing technical assistance and training to counties interested in the program. More than a third of the state's 23 counties have been helped to implement the program. For the first time in Wyoming, local governments are able to apply for safety funding by following a systematic procedure.


The rapidly expanding technologies involving chemical synthesis and screening, genomics, and bioinformatics are leading to the point where every gene product can be modulated as a therapeutic target. Thus, pharmaceuticals increasingly offer the potential to control disease processes. While great strides in understanding disease processes can come from this mechanistic approach (addressing "how?" questions), complete understanding is impossible without addressing the ultimate causation of disease processes. By addressing ultimate ("why?") questions, evolutionary thinking provides a firm theoretical framework for all biological processes, including those relating to disease. Of practical relevance for pharmaceutical development is an increased awareness of evolved responses and potential consequences of bypassing these defenses. Examples involving reproductive medicine, components of the acute phase response, apoptosis, and axonal regeneration are discussed. Drug Dev. Res. 52:439–445, 2001. © 2001 Wiley‐Liss, Inc.


The interactions of an E/A=70-MeV {sup 9}C beam with a Be target was used to populate levels in Be, B, and C isotopes, which undergo decay into many-particle exit channels. The decay products were detected in the HiRA array and the level energies were identified from their invariant mass. Correlations between the decay products were examined to deduce the nature of the decays, specifically to what extent all the fragments were created in one prompt step or whether the disintegration proceeded in a sequential fashion through long-lived intermediate states. In the latter case, information on the spin of the level was also obtained. Of particular interest is the five-body decay of the {sup 8}C ground state, which was found to disintegrate in two steps of two-proton decay passing through the {sup 6}Be{sub g.s.} intermediate state. The isobaric analog of {sup 8}C{sub g.s.} in {sup 8}B was also found to undergo two-proton decay to the isobaric analog of {sup 6}Be{sub g.s.} in {sup 6}Li. A 9.69-MeV state in {sup 10}C was found to undergo prompt four-body decay to the 2p + 2{alpha} exit channel. The two protons were found to have a strong enhancement in the diproton region and the relativemore » energies of all four p-{alpha} pairs were consistent with the {sup 5}Li{sub g.s.} resonance.« less


If one agrees that some form of continuing study or measurement of hospital utilization is necessary, how can this best be done? A variety of approaches have been employed in a variety of situations. All share the bias of the individual judgment of the physician evaluator. There is not only obvious difference in evaluation of care or length of stay or indications for admissions between physicians, but there is a distressingly difficult difference in evaluation on two occasions by the same physician. The only satisfactory solution yet proposed for such a problem in evaluation is to develop a measure of sufficient subtlety to indicate variations in hospital use regardless of individual shortcomings. A system of criteria for medical and surgical care created for each diagnosis, prepared by physicians in advance of the actual study of the hospital chart, is such a yardstick. This is not so impossible a job as


OBJECTIVE
To understand the association between stressful life event and onset of smoking among adolescents in China.

METHODS
Data on baseline survey from a 5-year longitudinal smoking prevention trail was used. Five thousand, five hundred and thirty-six students, from grade 7, 8 and 9 in 22 junior high schools all over Wuhan, China, had completed the survey on the onset of smoking in the past year and on stressful life events. Logistic regression analysis was used.

RESULTS
The results showed that 8.2% of the respondents reported the onset of smoking in the past year before the survey. The rates for male and female were 13.6% and 3.4% respectively while 7.8% for 7th graders, 9.1% for 8th graders and 8.3% for 9th graders. When gender, urbanicity and age were controlled with logistic regression model, the onset of smoking in general was significantly positively associated with the negative life events at school and family while negatively associated with positive life events in school and personal domain (P < 0.05).

CONCLUSION
Attention should be paid to help adolescents to cope with stressful life events in order to prevent and control the onset of smoking among adolescents.


Makes a comparison between DW and ODS,and then sheds light on the significance of conducting ODS operation.Consequently,it works out a plan for independently constructing and operating ODS combined with DW at the first stage according to the demand of constructing ODS by stages from a certain unit and probes into some cases concerning construction of operating it.


The results of automatic short answer scoring (ASAS) can be used to provide learning recommendations. However, previous studies on ASAS are focused on the quality of the scoring method, without considering giving feedback on the student performance in the exam sessions. Moreover, research on feedback in the learning activity is more concentrated on creating an adaptive learning process. Therefore, this study aims to combine the Automatic Short Answer Scoring method and an Automatic Recommendation System to create an adaptive feedback system that has the ability to personalize the recommendation of study materials for the student based on their exam result. This study uses a dataset of ten questions, including one reference answer per question. The experiment result shows the recommendation system gives the maximum similarity score at 0.8972, with the maximum average score for all questions is 0.801. Future studies may continue to examine a technique for automatically generating study materials from various resources.


Protest events provide information about social and political conflicts, the state of social cohesion and democratic conflict management, as well as the state of civil society in general. Social scientists are therefore interested in the systematic observation of protest events. With this paper, we release the first German language resource of protest event related article excerpts published in local news outlets. We use this dataset to train and evaluate transformer-based text classifiers to automatically detect relevant newspaper articles. Our best approach reaches a binary F1-score of 93.3 %, which is a promising result for our goal to support political science research. However, in a second experiment, we show that our model does not generalize equally well when applied to data from time periods and localities other than our training sample. To make protest event detection more robust, we test two ways of alternative preprocessing. First, we find that letting the classifier concentrate on sentences around protest keywords improves the F1-score for out-of-sample data up to +4 percentage points. Second, against our initial intuition, masking of named entities during preprocessing does not improve the generalization in terms of F1-scores. However, it leads to a significantly improved recall of the models.


Laterite is well known in Asian countries as a building material for more than 1000 years. It is a highly weathered material, rich in secondary oxides of iron and aluminum or both and hence its colour is reddish brown. In India, it occurs in Andhra Pradesh, Kerala, Tamil Nadu, Maharashtra, Karnataka, Goa. It is observed during the field investigation that the hard layer of laterites are under laid by loose material of different nature with a change in colour and considerable reduction in strength. The unique nature of laterite of changing strength and the presence of Lithomargic clay extending to considerable depth, alternate and wetting and drying make the behavior, properties and analysis of laterite imperative. The heavy rains in the recent past has given a wake up call to all engineers to analysis and prevent damages to cutting, slopes and foundations on lateritic soil. The laterite core and soil samples were taken from Verna Industrial Estate, which is located in Konkan belt of Goa. During the feasibility and preliminary design stages of the project when very little detailed information is available about laterite rock and soil its engineering properties can be determined by generating relationship between these properties. In the present work, an attempt is made to evaluate the shear strength parameters of lateritic soils and the effect of alternate wetting and drying on these parameters is studied. The soil sample is dried for twenty four hours and saturated for 1, 2, 5, 10, 15 and 21days, and the shear parameters are evaluated. Also, the effect of alternate wetting and drying on Atterberg limits is studied. From the experimental study it is found that after a number of alternate wetting and drying cycles, the lateritic soil starts loosing its strength as compared to the initial strength. Indian Geotechnical Conference – 2010, GEOtrendz December 16–18, 2010 IGS Mumbai Chapter & IIT Bombay


Three-dimensional (3D) integration technology has been proposed as a promising technology to provide small footprint, reduced wire-length, and the capability of heterogeneous integration. In particular, 3D IC is a good candidate to address the design issues in conventional analog/digital mixed-signal IC designs. In this work, we focus on modeling and analyzing the impacts of through silicon vias (TSVs) on mixed-signal ICs. Based on the analysis, a set of design methodologies for 3D mixed-signal ICs are proposed. The design methodologies are verified with a case study, in which a 12-bit successive approximation register analog-to-digital converter (SAR ADC) is re-designed by partitioning it into three stacked layers for 3D integration. The experimental results show that, compared to the traditional 2D counterpart, our 3D SAR ADC with optimized TSV placement can achieve significant area and power reduction, and performance improvement. Specifically, due to the isolation of substrate noise disturbance in our 3D design, the signal-to-noise-plus-distortion ratio (SNDR) is improved from 68.74 dB to 74.12 dB.


ABSTRACTThe metastatic properties of the M5076 tumor, a reticulumcell sarcoma of ovarian origin, were examined. This tumormetastasizes preferentially to the peritoneal viscera (liver, ovaries, spleen, and kidneys) regardless of the site or route oftumor cell injection. Subcutaneous tumor growth followed bydirect invasion into the peritoneum resulted in extensive generalized peritoneal involvement. However, when tumor cellswere injected in the dorsum, external ear, or footpad, fewerand primarily hepatic mA©tastasesdeveloped. Hepatic, splenic,ovarian, and renal tumor colonies were formed after i.v. injection of tumor cells.Radiolabeled tumor cells were used to study the arrest,distribution, and survival of tumor cells injected i.v. Thesetumor cells were rapidly arrested in the lungs and were retainedthere for 3 to 4 days. They then slowly detached, recirculated,and were arrested in the liver, where they subsequently developed into tumor nodules. These results strongly support the"soil-seed" hypothesis of metastatic growth and demonstratethat long-term retention of tumor cells in an organ need notresult in the formation of a clinically obvious tumor nodule.INTRODUCTIONIn the accompanying paper, we have described and characterized a murine tumor of spontaneous origin, identified byfunctional and ultrastructural studies as a reticulum cell sarcoma of macrophage origin (26). Here, we report on themetastatic patterns, distribution, and fate of cells from theM5076 reticulum cell sarcoma transplanted by different routesinto syngeneic C57BL/6 mice and show that this tumor lineselectively colonizes in the peritoneal viscera.The organ-specific nature of metastatic spread is well recognized, and studies of several animal tumor systems haveshown that the anatomical location of secondary tumor deposits is determined by both host and tumor cell properties (9).One approach to analyzing the properties of tumor cells responsible for such organ-specific growth has been the selection of variant lines from a parent tumor that colonizes inparticular organs (1, 2, 8, 22, 24, 27). Most metastatic solidtumors in rodents, however, metastasize to the lungs, regardless of the route of tumor injection (9). Because they exhibitselective patterns of metastatic growth that may exclude thelungs, it has been proposed that murine reticuloendothelialtumors may serve as good models for investigating organ-specific metastasis (5, 18, 19).We are using the M5076 tumor line in an attempt to determine factors responsible for specific patterns of metastatic


Samples of concrete contain various waste materials, such as iron particulates, steel balls of used ball bearings and slags from steel industry were assessed for their anti-radiation attenuation coefficient properties. The attenuation measurements were performed using gamma spectrometer of NaI (Tl) detector. The utilized radiation sources comprised 137Cs and 60Co radioactive elements with photon energies of 0.662 MeV for 137Cs and two energy levels of 1.17 and 1.33 MeV for the 60Co. Likewise the mean free paths for the tested samples were obtained. The aim of this work is to investigate the effect of the waste loading rates and the particulate dispersive manner within the concrete matrix on the attenuation coefficients. The maximum linear attenuation coefficient (μ) was attained for concrete incorporates iron filling wastes of 30 wt %. They were of 1.12 ± 1.31×10−3 for 137Cs and 0.92 ± 1.57 × 10−3 for 60Co. Substantial improvement in attenuation performance by 20%–25% was achieved for concrete samples incorporate iron fillings as opposed to that of steel ball samples at different (5%–30%) loading rates. The steel balls and the steel slags gave much inferior values. The microstructure, concrete-metal composite density, the homogeneity and particulate dispersion were examined and evaluated using different metallographic, microscopic and measurement facilities.


When a catastrophic event such as an earthquake (EQ) occurs, general guidelines related to the specific event particular location, must be dynamically adapted in near real time by ad-hoc team of experts in order to identify the most urgent recovery actions for the specific emergency. The procedure for hazard risk management, includes several pre and post disaster interventions to be considered in the preparedness and response phases of risk management. (STORM, 2018). In the case of EQs, the pre-disaster interventions, and level of preparedness are undoubtedly the most important phases in risk management. Therefore, possible EQ prediction, could help avoid disastrous effects caused by an EQ on vulnerable structures, such as these often located in cultural heritage sites. I this work, we propose a strategy for the calculation of the probability for a significant ( ) EQ occurrence in order to be co-evaluated within a decision making mechanism which could assist in reaching a high level of


The society of the 21st century is marked by a feeling of practicality and immediacy, resulting in increasingly fleeting and often weakened social relations. In view of this scenario, the present study sought to understand the main factors that lead the human being to develop an existential emptiness and to lose the meaning of life, reaching the point of committing an act as abrupt against himself, as suicide. This work was also used for the investigation on the theme of death and how it is perceived and seen by today's society. Such questions were addressed in the light of Logotherapy, the theory of Life Sense Psychotherapy, through a bibliographic research. In view of this, the work is done throughout the chapters, where the first chapter highlighted some sociocultural aspects of a society that denies the finitude of life, perceiving suicide as an abominable and despicable act. The next chapter addressed the aspects of Logotherapy, which perceives the need to find a meaning that encourages the subject to want to live. Finally, the third chapter promoted the analysis of the impact of existential emptiness and the search for a meaning in the formation of the subject's life, based on the theories and reflections of the psychologist and creator of logotherapy, Viktor Emil Frankl. With this literature review it was possible to investigate and understand the aspects of psychic suffering that result in an existential emptiness, because it is considered a factor of great relevance for the loss of the meaning of life, which triggers suicidal ideation or even the consummate act. The present work promoted and encouraged the reflection and deconstruction of the prejudice of our society on the theme about the finitude of life and suicide.


We investigate the dynamics of a pair of spinning spheres or microrotors in a fluid at low Reynolds numbers. These microrotors are each approximated by a rotlet, a fundamental singularity of the Stokes equation. Singularities of Stokes flows serve as useful theoretical models for microswimmers and micro-robots. Rotlet models of microswimmers have received less attention since a rotlet cannot generate translation by itself if the only control input is the rate of spin or strength of the rotlet. However a pair of rotlets can interact and execute net motion. In an unbounded domain of fluid, the positions of a pair of rotlets are not fully controllable due to the existence of an invariant. However, in a confined domain, we show that the positions of the pair of spheres are small time locally controllable. We show how control inputs can be constructed based on combinations of Lie brackets to move the rotlets from one point to another in the domain.


The spike glycoprotein (S) of SARS-CoV-2 mediates attachment of the virus to cell surface receptors and fusion between virus and cell membranes1. The receptor for SARS-CoV-2, like that for SARS-CoV, is the human cell-surface membrane protein ACE22–4. Membrane fusion activity, as for other class-1 fusion glycoproteins, requires S to be proteolytically cleaved into S1 and S2 that remain associated following cleavage4–7. SARS-CoV-2 is thought to have emerged from bats, possibly via a secondary host8,9. To better understand the transmission of SARS-CoV-2 we have determined the structure of its furin-cleaved S by cryoEM, which shows that cleavage at this polybasic amino-acid site increases the structural plasticity of the receptor binding region and facilitates the adoption of an open conformation that is required for it to bind to the ACE2 receptor. To investigate relationships between S proteins of SARS-CoV-2 and of the most closely related bat virus, RaTG138, we have determined and compared their structures and characterised biochemically their affinities for ACE2 and their relative stabilities. Whilst the overall structures are similar, there are key differences likely pertinent to virus infectivity. These include a more stable pre-cleavage form of human S, about 1000-fold tighter binding of SARS-CoV-2 to human receptor, and a higher proportion of S in the conformation required for binding ACE2 upon protease cleavage.


Taylor and Francis Ltd GERR041006.sgm 10.108 / 50980410001680679 Europe Romantic Review 50-9585 (pri t)/ 74 -4657 (online) Original Article 2 04 & Francis Ltd 5 0 00June 2004 Debbi Lee partm t of EnglishWashington State UniversityPullmanWA 99164USA firstname.lastname@example.com u 'There are upwards of 10,000 practising scoundrels in London, whose manoeuvers are daily directed against its unsuspecting inhabitant,' wrote William Kidd in his 1832 book London and All Its Dangers, Frauds, Iniquities, Deceptions, &tc. Kidd was not the only one warning Britons of such dangers. On any given day, a person in Romantic England could open one of the newspapers to find headlines like: 'Infamous Impostor,' 'Singular Case,' 'Fabrication,' 'Celebrated Hoax!' Impostors were threatening because they routinely disrupted cultural categories. Cross dressers like Mary Lacy and Mary Talbot, who put on men's clothes and sailed with the British Navy, or Monsieur D'Eon, the French diplomat and spy who at midcareer and mid-life suddenly announced that he was she, cast serious doubt on the construction of gender in the period. Class crossers like Beau Brummell, who died a poverty stricken beggar but who spent much of his life as the court dandy and friend of George IV, or Edward Wortley Montagu, who gave up the life of an aristocrat to live as a chimney sweep, questioned the official view of the social world in which a person's identity was largely determined by inheritance. Poetic forgeries, those of James Macpherson, Thomas Chatterton, and William Henry Ireland, challenged the myth of original poetic genius. Travel hoaxes, among the most notorious Christian Frederick Damberger, the Wittenberg printer whose fake travel narratives to Arabia and Africa confounded British journalists, and Mary Baker, a Devonshire servant who styled herself the exotic oriental royalty 'Princess Caraboo,' raised questions about the European desire to describe national characteristics and then categorize people according to a fixed system.


Abstract This paper considers the transformation of the optimal digital control problem to en equivalent discrete-time optimal control problem in the case of deterministic and stochastic sampling. The continuous-time system to be controlled is linear and disturbed by additive continuous-time white noise (not necessarily gaussian). The observations available at the sampling instants are in general non-linear and corrupted by discrete-time noise independent of the system noise (not necessarily additive, white or gaussian). The performance criterion is quadratic and an integral rather than a sum.


The article deals with the topical problem of college teachers' self-management in knowledge. The main function of this process should be the reproduction of knowledge (in the framework of teaching subjects) and the production of knowledge (through scientific research and methodological-teaching work) by the teachers of a college. The author distinguishes two types of self-knowledge, and suggests that self-knowledge is the ability to manage the five subsystems of a person. The article focuses on self-management as a special branch of management theory, aimed at individual self-improvement of a specialist in the cluster of self-management in knowledge.


Ibn Makawaih is a philosopher who focuses on morals. Ibn Miskawaih states that morality is a state of the soul of a person who encourages to do something without going through consideration of thoughts first. The purpose of moral education formulated by Ibn Miskawaih is the realization of an inner attitude that is able to encourage spontaneously to give birth to all good-value actions so that they can achieve perfection and obtain true and perfect happiness. There are three important things that can be understood as moral education material, namely: things that are obligatory for the needs of the human body, things that are obligatory for the soul and things that are obligatory for their relationship with fellow human beings. Ibn Miskawaih in his character concept emphasizes psychological and religious aspects to improve the quality of one's character.


During ship design, service speed is one of the crucial parameters in determining the operational economy of the vessel. As sufficiently exact calculation methods applicable to preliminary design stage are lacking, the so-called contract speed, the speed which a ship reaches in calm water, is usually cited. Żelazny (2015) developed a parametric method for calculating total ship resistance under actual weather conditions (wind, waves, sea current). This paper presents a parametric model of a ship's propulsion system (screw propeller – propulsion engine) as well as a method, based on both the resistance and propulsion system models, of calculating the mean statistical value of a ship's service speed under the seasonal weather conditions occurring on shipping lines. The method makes use only of basic design parameters, and may be applied in preliminary design phase of container ships.


Since the advent of multiple collector inductively-coupled plasma mass spectrometry (MCICP-MS), it becomes possible to learn about the isotope geochemistry of transition metals in natural systems. Modern scientific literature provides information about zinc stable isotope fractionation while the knowledge related to this element in environmental studies remains very poor. The study objects to improve the knowledge about zinc stable isotopes and additionally to test its potential as a tool tracer. The research was conducted in Nova Santa Rita municipality, RS, in galvanic industry area. Atmospheric vapors from industrial chimney and liquid effluents were identified as main sources of contamination. Total zinc, lead, cupper and cadmium contents were determined in soils, atmospheric particulate material, bottom sediments and stream water suspended material samples using ICP-MS (induced coupled plasma mass spectrometer) equipment. Zinc and lead isotopic fractions were measured in MC-ICP-MS spectrometer (multiple collector inductively-coupled plasma mass spectrometer) Neptune (Termofinnigan) in Paul Sabatier University (Toulouse, France) and in Federal University of Rio Grande do Sul (Porto Alegre, Brazil). Zinc, lead, cupper and cadmium contents indicate that zinc is the only element representatively found in anomalous concentrations. Comparing samples from each natural compartment, cupper and lead contents present low range of variation. Cadmium contents were lower than the accuracy of the analytical method for all samples. Lead isotopic results obtained in soils and bottom sediments samples indicate mainly geogenic origin for lead content. Comparing lead isotopic data with zinc isotopic data, a similar trend was observed for soil samples. The results reinforce that the zinc isotopic method is a potential tool to monitoring soils impacted by industrial activity. Zinc and lead isotopic data in bottom sediments indicate different isotopic behavior and pointed to depletion of heavier zinc fractions at this compartment, probably related to biochemical processes. The industrial vapors isotopic signatures are slightly different than the natural signature observed in non-contaminated soil. Considering the analytical precision of 0,1‰ for zinc isotopic analyses, natural processes may restrict the potential of zinc stable isotopes as a tool tracer.


Let be the number of eigenvalues not exceeding for the selfadjoint boundary problem with random potential , and let Our problem is to clarify the conditions under which this function will exist and to indicate methods for calculating it.In the present article we establish the existence of a nonrandom limit for a wide class of stationary ergodic potentials. This limit is calculated under the assumption that the potential is Markovian, and the argument is based on the well-known theorems of Sturm.At the end of the article we consider an example in which is a Markov process with two states. In this case the calculations can all be carried out completely in a practical way, with the result that we obtain a formula expressing by means of integrals of elementary functions.Bibliography: 9 items.


The effect on early embryo survival and development of a diallelic 1423A>G SNP found in the promoter region of the tissue inhibitor of metallop r teinase 1 gene ( TIMP1) was studied in an F 2 rabbit population. The F 2 population comes from High (H) and Low (L) lines s elected divergently for uterine capacity during 10 generations. A total of 171 and 159 intact does were slaughtered at 48 h and 72 h o f gestation respectively to determine whether TIMP1 gene was associated with ovulation rate, fertilization rate, early embryo survival and embry onic stage of development. We did not find differences between homozygote genotypes in ovulati on rate and fertilization rate at 48 and 72 h of gestation. At 48 h of gestation, AA genotype showed a similar early embryo survival and embryonic stage of development to GG genotype. However AA gen otype, the genotype most frequent in the line selected to increase uterine capacity, had 0.88 emb ryos (P(D>0)=90%) more at 72 h of gestation than GG genotype and also had a higher embryonic stage o f d velopment, showing a lower percentage of early morulae (Dm=-16.33%, P(D<0)=92%), a higher percentage of compa cted morulae (Dm=19.85%, P(D>0)=92%), and similar percentage of blastocysts (D=3.52%) at this stage of gestation. A more advanced embryonic stage of development seems to be associated with a higher embryo survival at 72 h of gestation.


As box structure is employed as inner form of cast-in-situ concrete slab to form hollow two-way slab,the slab deadweight is greatly reduced.With less concrete quantity,light deadweight and good resistances to earthquake,sound and heat,it has obvious multi-benefits.


4‐Tert‐butylpyridine (tBP) is an important additive in triarylamine‐based organic hole‐transporting materials (HTMs) for improving the efficiency and steady‐state performance of perovskite solar cells (PVSCs). However, the low boiling point of tBP (196 °C) significantly affects the long‐term stability and device performance of PVSCs. Herein, the design and synthesis of a series of covalently linked Spiro[fluorene‐9,9′‐xanthene] (SFX)‐based organic HTMs and pyridine derivatives to realize efficient and stable planar PVSCs are reported. One of the tailored HTMs, N2,N2,N7,N7‐tetrakis(4‐methoxyphenyl)‐3′,6′‐bis(pyridin‐4‐ylmethoxy) spiro[fluorene‐9,9′‐xanthene]‐2,7‐diamine (XPP) with two para‐position substituted pyridines that immobilized on the SFX core unit shows a high power conversion efficiency (PCE) of 17.2% in planar CH3NH3PbI3‐based PVSCs under 100 mW cm−2 AM 1.5G solar illumination, which is much higher than the efficiency of 5.5% that using the well‐known 2,2′,7,7′‐tetrakis‐(N,N‐di‐p‐methoxy‐phenyl‐amine)9,9′‐spirobifluorene (Spiro‐OMeTAD) as HTM (without tBP) under the same condition. Most importantly, the pyridine‐functionalized HTM‐based PVSCs without tBP as additive show much better long‐term stability than that of the state‐of‐the‐art HTM Spiro‐OMeTAD‐based solar cells that containing tBP as additive. This is the first case that the tBP‐free HTMs are demonstrated in PVSCs with high PCEs and good stability. It paves the way to develop highly efficient and stable tBP‐free HTMs for PVSCs toward commercial applications.


Infections are a substantial cause of morbidity and mortality in patients with systemic lupus erythematosus (SLE), accounting for one-quarter of all deaths1,2. The mechanisms for increased susceptibility to infections in patients with SLE are classically attributed to disease- and treatment-related factors. Polymorphisms in the mannose-binding lectin3 protein, which helps in host defense by activating the complement cascade, have been reported as a risk factor primarily for bacterial infections in SLE3. Patients with SLE may also have acquired hypogammaglobulinemia (as reviewed by Yong, et al 4) or hyposplenism, which leads to increased susceptibility to infections with encapsulated organisms. Acquired neutropenia has also been cited as a risk factor for infections in SLE5 and for fungal infections in other populations6. Corticosteroids are frequently necessary in the treatment of SLE, resulting in diminished cellular immunity. Immunosuppressant therapy also clearly increases the risk of bacterial infection7.

Invasive fungal infections were initially defined in 20028, with revisions occurring in 2008, including a change in terminology to "invasive fungal disease" (IFD)9 by the European Organization for Research and Treatment of Cancer/Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC/MSG) Consensus Group. Proven IFD are subdivided into molds ( Aspergillus ) and yeasts ( Candida species and Cryptococcus ) and depend on culture or microscopic analysis from sterile anatomic sites, blood cultures, or cryptococcal antigen in cerebrospinal fluid. Separate criteria …

Address correspondence to Dr. Barber; E-mail: cehbarbe{at}ucalgary.ca


ABSTRACT The elongating mouse anteroposterior axis is supplied by progenitors with distinct tissue fates. It is not known whether these progenitors confer anteroposterior pattern to the embryo. We have analysed the progenitor population transcriptomes in the mouse primitive streak and tail bud throughout axial elongation. Transcriptomic signatures distinguish three known progenitor types (neuromesodermal, lateral/paraxial mesoderm and notochord progenitors; NMPs, LPMPs and NotoPs). Both NMP and LPMP transcriptomes change extensively over time. In particular, NMPs upregulate Wnt, Fgf and Notch signalling components, and many Hox genes as progenitors transit from production of the trunk to the tail and expand in number. In contrast, the transcriptome of NotoPs is stable throughout axial elongation and they are required for normal axis elongation. These results suggest that NotoPs act as a progenitor niche whereas anteroposterior patterning originates within NMPs and LPMPs. Summary: During anteroposterior axis elongation, neuromesodermal and lateral mesoderm axial progenitors undergo dynamic transcriptomic change, while the adjacent notochord progenitors are stable and coordinate elongation.


Atom transfer radical polymerization(ATRP) is the "Controlled/Living" new technology developed for the past two decades.ATRP reactions,where metal catalysts are utilized in combination with ligands yielding well-controlled structures and narrow molecular weight distributions,has been carried out since 1995.This review summarizes such recent research activities.The synthesis strategies of anti-fouling and/or anti-bacterial surfaces and materials via ATRP are described in detail.The highly robust and versatile ATRP technique is particularly suited for the preparation of functional surfaces including high-capacity exchange membranes for chromatographic bioseparations.This contribution describes the method that hydrophilic polymer is grafted or blocked on surface or material by ATRP to prepare well-structured functional materials or membranes.The ATRP reaction can control the graft or block chain length and density with polymerization time or monomer and initiator concentration in a linear fashion,which makes the hydrophilic material bonding stably on the hydrophobic membrane materials,and also effectively controls pore sizes and pore distributions of the membrane surface without changing the properties of base membrane.The separation performance of resulting membrane is improved considerably.The research activities in the last decade indicate that ATRP has become an essential tool for the design and synthesis of advanced,noble and novel materials and membranes.


In relativistic diodes, ions are emitted from the anode plasma surface. The space charge of these ions enhances the electron emission. One−dimensional analysis and two−dimensional computer simulation are used to show the necessity of including this effect in any realistic diode theory.


Abstract I offer some responses to Prosser's 'Experiencing Time', one of whose goals is to debunk a view of temporal experience somewhat prevalent in the metaphysics literature, which I call 'Perceptualism'. According to Perceptualism: (1) it is part of the content of perceptual experience that time passes in a metaphysically strong sense: the present has a metaphysically privileged status, and time passes in virtue of changes in which events this 'objective present' highlights, and moreover (2) this gives us evidence in favor of strong passage. Prosser argues that perception cannot be sensitive to whether the strong passage obtains, and therefore cannot represent strong passage in a way that gives us evidence of its truth. Although I accept this conclusion, I argue that Prosser's argument for it is problematic. It threatens to over-generalize to rule out uncontroversial cases of perceptual knowledge, such as our knowledge that we live in a spatial world. Furthermore, a successful argument ruling out perceptual evidence for strong passage would have to give constraints on the theory/observation distinction of a kind not provided by Prosser's discussion. I also comment on several other parts of the book.


Biographies should be read with discretion. The portraits which they are meant to present are far too often created in the writer's own image. The tales they tell are usually lopsided and lack that depth of perspective which shows the whole of a character, with its contradictory features and its facets of changing inclinations and opinions. I for one prefer first-hand information, such as is contained in autobiographies—even if some of their facts should prove to be fiction, the way of telling them mirrors the author. In a sense, all creative artists are autobiographers. Composers, in particular, cannot help revealing themselves in their works. Schoenberg claimed that he, being a teacher of composition, had a rare opportunity of getting to know his students: the music they wrote disclosed not only their gifts, but also their characters.


This column presents a dialogue with German nurse scholar Gerd Bekel and United Kingdom nurse scholars, Francis C. Biley and Kirstin Fragemann, who share their respective visions and understanding of each country's vision of nursing, healthcare, and quality of life in the year 2050.


Preface. Chapter 1. A Short Insight into Probabilistic Combinatorial Optimization. Chapter 2. The Probabilistic Maximum Independent Set. Chapter 3. The Probabilistic Minimum Vertex Cover. Chapter 4. The Probabilistic Longest Path. Chapter 5. Probabilistic Minimum Coloring. Chapter 6. Classification of Probabilistic Graph-problems. Chapter 7. A Compendium of Probabilistic NPO Problems on Graphs. Appendix A. Mathematical Preliminaries. Appendix B. Elements of the Complexity and the Approximation Theory. Bibliography. Index.


Suppose that a curve Г of constant shape moves in space so as to trace out a surface Σ. The problem has suggested itself to various authors whether it is possible for Г to be always a line of curvature, geodesic, asymptotic line, etc., on Σ. The following elementary method of solving such problems may be of interest.


Let H be a separable, infinite dimensional Hilbert space and let S be a countable subset of H. Then most positive operators on H have the property that every nonzero vector in the span of S is cyclic, in the sense that the set of operators in the positive part of the unit ball of B(H) with this property is comeager for the strong operator topology. Supposeis a regular cardinal such that • > !1 and 2 <• = •. Then it is relatively consistent with ZFC that 2 ! = • and for any subset S ‰ H of cardinality less thanthe set of positive operators in the unit ball of B(H) for which every nonzero vector in the span of S is cyclic is comeager for the strong operator topology.


Background Reactive oxygen species may contribute to the pathogenesis of asthma. Functional genetic polymorphisms of antioxidant enzymes, superoxide dismutase (SOD) and catalase are good candidates for asthma susceptibility.


Individuation in relation to father and mother is one of the key developmental tasks of adolescence, and has been conceptualized as gaining autonomy while maintaining relatedness to parents. Research on high-conflict, divorced and step-families suggests that specific stressors in these family types may compromise successful individuation by undermining relatedness, triggering insecurities or leading to early independence. This study takes a typological approach (1) seeking to identify distinct patterns of adolescents' relationships to mother and residential father figure (biological or stepfather), (2) testing the effects of family structure and dynamics, and (3) investigating links between type of individuation and adolescents' adjustment. The sample consisted of N = 649 adolescents in Germany aged between 10 and 20 years who lived in nuclear, single-mother or stepfather families. The Munich Individuation Test of Adolescence (MITA) was used to assess individuation. For n = 473 adolescents data on individuation in relation to the biological or stepfather were available. Cluster analyses resulted in three types of individuation regarding mothers and four types regarding fathers. In particular, children from (nuclear) families with high interparental conflict were at risk for an insecure ambivalent relationship. Securely individuated youth showed significantly better adjustment in a variety of outcomes.


Intrauterine malnutrition (IM) during the early stages of development can alter the function of organs and tissues and can predict a lifetime of increased risk for adverse health outcomes, such as diabetes and hypertension. The kidney plays a key role in the development of hypertension programmed by IM, with the participation of the RAS. Our objectives were to study ACE activity and angiotensin peptides levels in tissues. Pregnants Wistar rats were separated into two groups: control group (C), fed ad libitum, and malnourished group (D) submitted to food restriction (diet 50% of the amount of feed consumed by the group C). After birth the offspring were kept as experimental groups C and D, respectively. At 4 months of age, the animals were sacrificed, heart and kidney tissues were collected to quantify angiotensin peptides and ACE activity. The offspring born with low birth weight. Kidney ACE activity was higher in group D compared to group C (299 ±86.7 vs. 253.4 ±84.82 mU/mg, p<0.05), differing from Heart (D versus C: 0.15 ± 0.08 vs. 0.24 ±0.09 mU/mg). Group D presented high blood pressure values compared to group C (140.6 ±2.8 vs. 124,3±2.6 mmHg). Kidney and heart Ang II levels were increased in group D being significant when compared to group C (238.26 ±25.1 vs. 161.85 ±45.6 pmol/g and 397.89±74.9 vs. 223.33±48.7 pmol/g, p<0.05, respectively). The same was observed for Ang I. The vasodilator peptide Ang1-7 levels in group D from kidney and heart were lower in comparison with group C, thus emphasizing an enabling environment for hypertension (220.74 ± 48.74 vs. 288.09 ± 47 pmol/g and 152.1±41.2 pmol/g vs. 228.93±41.2 pmol/g, p<0.05, respectively). Our results indicate that perturbed maternal nutritional status alters tissue RAS resulting in higher blood pressure in the offspring, demonstrated by increased renal ACE activity and Ang II levels, with reduced Ang 1-7. The increase of Ang I and II in the heart, despite low ACE activity in this tissue suggests the activation of RAS alternative pathways. This study describes for the first time that low levels of Ang 1-7 contributed to the early development of hypertension.


The use of microcomputer for the control and operation of West German railroad stock is reported. In 1979, prototypes of an automatic train and braking control on an electric locomotive class 111 of the West German Railroad System were put into operation, along with a vehicle control device using microcomputer technology. A description of these prototypes is given.


A possible application of hyperspectral remote sensing regards the assessment of light pollution due to cities and industries. In this paper we introduce the results from a remote sensing campaign performed in September 2001 at night time. For the first time nocturnal light pollution was measured at high spatial and spectral resolution us- ing two airborne hyperspectral sensors, namely the Multispectral Infrared and Visible Imaging Spectrometer (MIVIS) and the Visible InfraRed Scanner (VIRS-200). These imagers, generally employed for day-time Earth remote sensing, were flown over the Tuscany coast (Italy) on board of a Casa 212/200 airplane from an altitude of 1.5-2.0 km. We describe the experimental activities which preceded the remote sensing campaign, the opti- mization of sensor configuration, and the images as far acquired. The obtained results point out the novelty of the performed measurements and highlight the need to employ advanced remote sensing techniques as a spec- troscopic tool for light pollution monitoring.


We have developed a new optical flying head integrating a solid immersion lens and a flying slider for application to an ultra high-density storage system. We report a practical method of fabricating this head. The flying head has a stable flying attitude at the flying height of 50nm.


Dynamic optimization problems (DOP) widely exist in many application fields and remain a challenge. The multi-population evolutionary computation approach is an efficient framework for solving the DOPs. The key issue of the multi-population approach is how to efficiently generate subpopulations in new environment by well reusing historical information in past environments. However, most existing works try to divide the population into small ones merely considering the individuals' distribution, which may have the limitation that the partition leads to the unbalanced computational resources allocation among subpopulations. To address this limitation, we propose a historical information-based differential evolution (HIDE) to effectively solve the DOP. Firstly, a region-based subpopulation initialization (RSI) strategy is proposed to generate multiple subpopulations in the new environment in a balanced way. By initializing multiple subpopulations in different regions of the search space, the diversity of the population is enhanced, which is helpful to solve the DOP with multiple peaks. Secondly, to fully make use of the found peaks of the previous environments, an archive-based historical information reuse (AHIR) strategy is put forward to manage and reuse the historical information to guide the search in the new environment. Experiments have been carried out on the moving peaks benchmark (MPB), which is a commonly used DOP test suite. Experimental results show that the proposed HIDE algorithm generally outperforms the classic DE algorithms with different parameter settings and some existing competitive state-of-the-art DOP approaches.


The forthcoming general election has reignited debates about the future of the NHS and its staff. What are the parties' pledges for the next four years?


Pulmonary artery hypertension (PAH) is a debilitating disease, the hallmark of PAH is pulmonary arterial smooth muscle cells (PASMCs) proliferation and pulmonary pressure increasing. This study investigated the mechanisms of KMUP-1 inhibited pulmonary artery (PA) contraction and proliferation in curing PAH. In the acute model of PAH induced by thromboxane A2 (TXA2)-mimetic U46619, KMUP-1 restored blood oxygenation and relaxed vasoconstriction by enhancing endothelial nitric oxide synthase (eNOS), soluble guanylate cyclase (sGC) and protein kinase G (PKG), and inhibited phosphodiesterase-5A (PDE-5A), RhoA/ROCK expression. The inhibition of KMUP-1 on ROCK expression was waken by ODQ、L-NAME and SQ22536. In the absence or presence of U46619 (0.5 ?嵱). Similarly, in isolated pulmonary artery (PA), KMUP-1 relaxed phenylephrine (10?n?嵱)- serotonin (5-HT)- and U46619 (0.5 ?嵱)-induced vasoconstriction, the relaxation effects of KMUP-1 are waken by ODQ、L-NAME and SQ22536. In the chronic model of PAH induced by monocrotaline (MCT), KMUP-1 prevented MCT-induced PAH over long-term administration. increased eNOS expression and reduced MYPT1 (myosin phosphatase target subunit 1) phosphorylation, RhoA/ROCK, 5-HT transporter (5-HTT) expression in lung tissue, reduced plasma 5-HT increasing, PA wall thickening, proliferation and right ventricular hypertrophy (RVH). Incubating PASMCs with KMUP-1 inhibited thapsigargin-induced Ca2+ efflux and angiotensin II-, 5-HT-induced Ca2+ influx. KMUP-1 (1-100 ?嵱) inhibited 5-HT-induced RhoA/ROCK expression, while KMUP-1, Y27632 and simvastatin at 10 ?嵱 inhibited 5-HT-induced 5-HTT expression and KMUP-1 inhibited 5-HT-induced phosphorylation of AKT and ERK1/2 in PASMCs. KMUP-1 (1-100 ?嵱) concentration-dependently increased the expression of eNOS and 5-HT2B and production of NO in human pulmonary arterial endothelial cells (HPAEC), 5-HT2B receptor antagonist SB200646 decreased the effects of KMUP-1 on eNOS. In radioligand binding, binding ability of KMUP-1 was 5-HT2B > 5-HT2A > 5-HT2C. KMUP-1 inhibits MCT-induced PA proliferation by binding to 5-HT2A, 5-HT 2B and 5-HT 2C receptors, increasing endothelial eNOS/5-HT2B receptor expression and inhibiting 5-HTT/RhoA/ROCK expression and AKT/ERK phosphorylation. These findings suggest that KMUP-1 relieves and prevents PAH via enhancement of eNOS to releases NO and create a cGMP-dependent inhibition of RhoA/ROCK and Ca2+ desensitization in PASMCs. KMUP-1 inhibits MCT-induced PA proliferation by binding to 5-HT2A, 5-HT2B and 5-HT2C receptors, increasing endothelial eNOS/5-HT2B receptor expression and inhibiting 5-HTT/RhoA/ROCK expression and AKT/ERK phosphorylation. In conclusion, KMUP-1 has the potential to reduce vascular resistance, remodeling, hyperplasia and RVH in treating PAH.


We describe a design that uses 3D printed parts and off-the-shelf components to create an inexpensive system for automated storage and retrieval of microplates. In this way, a robotic system for storage of 24 plates can be built for less than $ 400.


The aim of the present investigation is to model a tubular electrochemical reactor for the treatment of synthetic dye wastewater. The tubular reactor was modeled and solved by finite difference method. For the model solution, the column was divided into 11 nodes in the axial direction and the variation in the radial direction has been neglected. An initial dye concentration of 200 mg Lwas taken in the reservoir. The reactor was operated in a batch with recirculation operation. Based on preliminary experiments all parameters have been optimized. The model simulation is compared with the experimental value and it is observed that the model fairly matches well with the experiment. The modeling of tubular electrochemical reactors for dye waste water treatment could be useful in the design and scale up of electrochemical process.


A 57‐year‐old woman presented with a widespread papulonodular eruption. The dermatitis had appeared about 1 week after her return from a trip to the Red Sea, where she had come into contact with a shoal of unidentified jellyfish; however, that contact had not been followed by cutaneous lesions and/or symptoms. The patient also stated that she had had previous contacts with jellyfish during other trips to exotic seaside resorts.


Measurements of the total power radiated by turbo jet engines have been analyzed by dimensional techniques. Under the assumption that the noise is created by an aerodynamical mechanism, the acoustic power may be set proportional to the mechanical power in the jet stream. Then the factor of proportionality must be a dimensionless function of the average properties of the jet stream. The dimensionless proportionality function may be shown to be a function of four dimensionless ratios, but physical arguments indicate that at least two of the four ratios may be relatively unimportant. The dimensionless proportionality function may be determined by plotting the acoustic power as a function of the mechanical power. Sixty‐eight separate measurements on various types of turbo jet engines under both free‐field and reverberant conditions have been examined. In each case the total acoustic power was determined by suitably integrating over space and frequency. The results show that the proportionality function may be...


A kind of hybrid membrane process, which integrated powdered activated carbon (PAC) with membrane bioreactor (MBR), was designed for bench scale experiment for micro-polluted surface water treatment. Molecular weight analysis was used to evaluate the efficiency of each unit process and the integration of them. The result of analysis indicated that organic molecules in the treated water from PAC-MBR process were concentrated on the section of below 1000, while PAC adsorption could enhance the removal efficiency of this section due to the high percent of biodegradation recalcitrant organic matter with low molecular weight. It was demonstrated that PAC adsorption and biological treatment promoted each other in PAC-MBR process, with a removal efficiency of 70% for COD Mn and UV 254, 100% for UV 410 and 92% for ammonia nitrogen in its stable stage.


Abstract. With the continuous growth of the global population, large-scale public gatherings have become more common, and crowd management at these gatherings has become an urgent problem for public safety management. Crowd motion analysis and early warning based on crowd motion segmentation in video surveillance systems has become an important research topic in computer vision. A translation domain segmentation (TDS) model based on improved cosine similarity (ICS) is proposed to segment moving crowds with different crowding levels and complex motion modes. The method reconstructs the objective function of the basic TDS model by ICS to simultaneously measure the difference between both magnitude and direction of two vectors; thus, undersegmentation due to the magnitude difference can be avoided. By switching between "localization" and "globalization" modes of the objective function, the algorithm can be applied to segment crowds with different densities and motion states. Moreover, by simultaneously introducing local motion magnitude and local frame difference magnitude thresholds, nonforeground regions can be excluded from the initial regions during region evolution. Experimental results show that the proposed method achieves superior performance and higher accuracy compared to existing flow field-based methods when applied to complex scenes containing moving crowds.


A new seed-mediated growth technique for synthesizing gold nanorods (NRs) by using H2O2 as the weak reducer in the presence of a binary surfactant mixture is reported. Gold NRs prepared at different amounts of H2O2 and the gold seeds solution were characterized by transmission electron microscopy (TEM) and visible–near infrared spectroscopy. Gold NRs with tunable aspect ratio from 4.5 to 7 can be obtained and the corresponding longitudinal plasmonic wavelength of the produced gold NRs are tunable from 810 to 1140 nm. This method provides a new pathway for synthesis of gold NRs with a wide range of longitudinal plasmonic peaks, which have potential applications in optoelectronics and biomedicine.


The use of formal methods and formal techniques in industry is steadily growing. • In this survey we shall – characterise what we mean by software development;


Binary complexes of maleic acid with toxic metal ions such as Pb(II), Cd(II) and Hg(II) have been studied in 0.0-2.5% v/v tritonX-100 (TX100) - water media at 303 K  at an ionic strength of 0.16 M. The active forms of the ligand are LH 2 , LH - and L 2- . The derived 'best fit' chemical speciation models are based on crystallographic R-factors, χ 2 and Skewness and Kurtosis factors. The predominant species formed are of the type ML 2 , ML 2 H and ML 3 . The trend in variation of complex stability constants with change in the mole fraction of the medium is explained on the basis of prevailing electrostatic and non-electrostatic forces. The species distribution as a function of pH at different compositions of TX100-water mixtures and plausible speciation equilibria are presented and discussed. KEY WORDS : Maleic acid, TritonX-100, Toxic metal ions, Mole fraction, Binary complexes Bull. Chem. Soc. Ethiop. 2014 , 28(3), 383-391. DOI: http://dx.doi.org/10.4314/bcse.v28i3.7


This essay analyzes the action plan that will be carried out by public institutions of
higher education from the perspective of university autonomy, for the correct adaptation of
the budget classification system, so that universities unify budget information and embrace to
international standards of public finance. Likewise, it is analyzed how through integrated
work of the largest public universities in the country, a successful implementation process is
sought, which in the long term will be reflected in a higher level of transparency and how
they make use of efficiency, therefore, with available resources to achieve your missional
purposes.


This essay is a reflexive study of congressional ghostwriting. A prominent politician, Robert Michel (R‐Ill.), and a prominent political speechwriter, William Gavin, reflect on one another's roles in the process of speech composition. Emphasis is on the interpersonal relationship between the principal and his ghost and how that relationship structures and defines the composition process.


There are approximately 25 million small businesses and 10.5 million self-employed individuals in the United States.1 Of these self-employed Americans, women entrepreneurs represent the fastest growing economic trend in the United States.2 According to the Center for Women's Business Research, w


My two objectives for this paper are: first, to present a geometrical model for membrane structure,l+ and second, to derive some fundamental principles of membrane structure that will have wide applicability. Two particular membrane systems will be used as examples: the retinal rod disk membrane and the cytochrome oxidase membrane. These two were chosen since, although they are both relatively simple, they differ in significant ways and thus illustrate different features of membranes. Membranes are composed primarily of two major classes of compounds, lipids and proteins. If we are to understand the structure of membranes, we must first understand the structure and properties of these component classes of molecules. In what follows therefore, I will briefly discuss the structure of lipids, then consider the shape and properties of membrane proteins, and finally take up the problem of the arrangement of the lipids and proteins in membranes.


Abstract In most investigations, genetic and environmental factors have been shown to interact in altering the progression of ageing related disease including stroke and cognitive decline. The peri-operative period appears to be no different, with environmental (operative) and genetic factors interacting to determine the presence, absence or severity of neurological outcomes. In our initial work we confirmed that apolipoprotein E4 (apoE4) alters cognitive function after coronary artery bypass graft (CABG), the mechanism of this association apparently being related to atherosclerosis and inflammatory factors. These findings are consistent with multiple studies that have shown an important role of apoE in the modulation of neurological injury and recovery following a variety of acute ischaemic insults including intra-cerebral haemorrhage, closed head injury, acute stroke and dementia pugilistica. More recently we have found that polymorphism of the GPIIIa constituent of the platelet integrin receptor, GPIIb/IIIa (PL A2 ) polymorphism is also associated with early post-operative cognitive decline. The association of multiple genetic factors with the incidence or severity of neurological injury is not surprising, since the factors that alter cerebral injury and recovery are complex. Similarly, there are genetic factors that determine the occurrence of tissue injury and its recovery, including genes that modulate atherosclerosis, emboli, inflammation, thrombosis and vascular reactivity. We have only begun to scratch the surface in our understanding of functional genomics as it applies to peri-operative outcomes. Functional genomics, as applied to complex human disease, will require a unique combination of cutting-edge genetics and large, highly phenotyped patient populations in order to further our understanding of the complex genetic–environmental interactions. This chapter will concentrate initially on the broad classes of genetic factors that may play a role in neurological injury and recovery, and will conclude with our current data on those genetic factors that predict neurocognitive decline after cardiac surgery and the potential mechanisms driving these associations.


In this paper, we propose an energy management system with hybrid solar and wind renewable energy system (RES) with Multilevel inverter to give a lossless power to load. This system continuously receives the battery storage and power consumption after it checks the these value with default value if power consumption is exceeds default value means it turn off  the loads. We are assigns the priority to the loads in order to overcome the user inconvenient. To increase PV module output MPPT is used. The existing system uses only boost converter, in our paper boost converter is combined with buck converter used because the PV module can produce high voltage  than DC-bus voltage. Buck converter used to step down purpose. In this  system  on-line configuration check and buck-boost mode transition will be presented. Experimental results measured from three-string MPPTs with EMS the maximum power level of 10 kW are used to verify the analysis and discussion with hybrid cascaded multilevel inverter. DOI: http://dx.doi.org/10.11591/ijece.v4i1.4529


Spectra of the Kleinmann-Low nebula in Orion detected the 84.42 and 84.60 micron transitions between the 2Pi(3/2) J = 7/2 and 2Pi(3/2) J = 5/2 levels of OH with respective fluxes of 1 x 10 to the -17th and 1.4 x 10 to the -17th W/sq cm. When compared to the 119 micron flux levels of OH discussed by Watson (1982) and the 163 micron flux levels of OH by Viscuso et al. (1985), these results suggest appreciable self-absorption of OH line radiation within the nebula. The CO emission due to the J = 31 to 30 rotational transition at 84.411 microns makes a substantial contribution to the observed 84.22 micron flux, and is probably at least partially absorbed at the 84.42 micron OH transition frequency. 7 references.


: Various controllability types are demonstrated for a circular membrane with rotationally symmetric initial data and boundary control depending on time only. We prove that the set of initial states, which can be steered to rest in the critical Lime interval (equal to the diameter of the membrane) by means of L 2 -controls is dense in the energy space but contains no eigenmode. We also show that any initial data from a Sobolev space can be transferred to a stationary state. The proof is based on study of exponential families arising in tbe approach using the method of moments.


ion to build up pure theory toward the complex, producing explanations a contrario. This procedure, named the "method of imaginary constructions" by Mises, Gunning renames the "method of contrasting images of functions," and uses it, to illustrate, to explain the functions of an entrepreneur by contrasting them with those of an entity in abstraction from not only entrepreneurial but also human qualities, i.e., a "robot." The third part, treated rather separately and later in the book, is what Gunning calls the "method of teleology." (His rationale for this sequencing is at p. 13.) Gunning seeks to employ his clarification to extend Mises's economic theory concerning entrepreneurship, the "simplest and most fundamental case" of the firm [p. 216], and what Gunning calls guaranty provision, rights creation, and market creation. He does not deal with Mises's ideas about interest, money, trade cycles, international trade, what Mises called interventionism, and socialism. Among Gunning's conclusions, one is that Mises's method stems from a "devastating critique" of "unhuman" positivism applied to the study of human action [pp. 8, 22, 23, 226], and is a corrective to the "elitism" of most modern economists [pp. 23, 24, 227], for whom Gunning has scorching comments [pp. 9, 10]. Another, and the "most obvious implication of this book," is that "to the extent that economists are interested in the distinctly human part of economic behavior, economics, including what has come


A cryogenic waveform digitizer ASIC (CryoSCA) based on switched capacitor array has been developed for HPGe detector array for dark matter (CDEX: China Dark Matter Experiment) and neutrino experiments. A 180 nm CMOS process was used and the I-V characterization of the MOS transistors was firstly measured at liquid nitrogen. Higher threshold voltage, improved carrier mobility, smaller subthreshold slope and higher gain were observed and measured than room temperature. CryoSCA has integrated 16 channels of waveform sampling and digitization circuit. Each channel consists of two sample blocks of 32-cell working in ping-pong mode, a 256-cell storage block and 32 parallel Wilkinson type ADCs. The digitized data will be sent out in serial. The sampling frequency is up to 100 MS/s and the resolution is above 10 bit at liquid nitrogen. The ADC conversion time is about 50 μs and the readout frequency is up to 200 MHz. Several design techniques have been adopted for low temperature operation, including adjusting bias externally and bandgap referred ramp current. The power consumption of core structure is simulated to be 2.3mW/ch, the INL of the ASIC can be better than 0.2% for 1 V dynamic range. Detailed design and test results will be present in the paper.


8 ASUBTITLE: WITH A 1992 LOSS OF $133 MILLION, IT'S A TOUGH SELL : FRENCH GOVERNMENT CONTINUES TO SEEK PARTNER FOR SHIPPING LINE.


Author(s): Wu, Yu-Shu; Lu, Gouping; Zhang, Keni; Bodvarsson, G.S. | Abstract: Even with the significant progress made in modeling flow and transport in fractured rock in the last few decades, characterizing fractured reservoirs remains a great challenge. This is because of the inherent complexity within actual fractured reservoirs, from multiphase flow and transport to the spatial variability of the fracture network. To investigate coupled processes of fluid and heat flow and chemical isotopic transport in the highly heterogeneous, unsaturated fractured tuff of Yucca Mountain (a proposed underground repository site for storing high-level radioactive waste of the U.S.), we present an integrated modeling methodology. The proposed modeling approach integrates a wide variety of moisture, pneumatic, thermal, and geochemical isotopic field data into a comprehensive three-dimensional numerical model for modeling analyses. The model is then used for the evaluation of unsaturated percolation fluxes and flow patterns, which is the most important goal of the site characterization. In particular, the results of this evaluation indicate that moisture data, such as water potential and liquid saturation in the rock matrix, are not sufficient to determine in situ percolation flux, whereas temperature and geochemical isotopic data provide better constraints to net infiltration rates and flow patterns. In addition, pneumatic data are found to be extremely valuable in estimating large-scale fracture permeability. The integration of hydrologic, pneumatic, temperature, and geochemical data into modeling analyses is thereby demonstrated to provide a practical modeling approach for characterizing flow and transport processes in complex fractured reservoirs.


The swimbladder in the sand goby, Pomatoschistus minutus, collected in shallow waters of the Oslofjord, Norway, was studied. As the literature on swimbladders in gobies appeared to be confusing, a short review of relevant literature has been made. On average, the volume of the swimbladder in the sand goby expressed as percentage of the body weight was found to be 4·7 % in May and 2·5 % in June. The significance of this volume variation is discussed.


The grammar Arte de la lengua ilocana (1627) was written by the Augustinian Francisco Lopez (?-1627) in order to learn the language and to be able to spread the Christian doctrine in the Philippines. It is the first description of this Austronesian language. It is written in Spanish and based on data from an oral corpus and translated texts, mainly doctrines and gospels. It has almost 200 pages divided in two parts: morphology and verbs. There is also the usual license, a poem written by an Ilokano native, an index and an errata sheet. It follows the lead of Antonio de Nebrija's grammar, because, as the author said, the missionaries had learnt Latin with the help of Nebrija's books, so it was easier for them to learn a new language using the usual methods. However, Lopez includes some innovations, because Ilokano is very different from Latin. To sum up, this grammar was very didactic, and so complete and easy to use that any missionary who wanted to learn Ilokano had to study it and could do it quickly because of its graphics and translations.


My plenary will explore the historical and ecological roots of the subdisciplines ≪conservation biology≫ and ≪behavioural ecology≫, which together make up the backbone of this session. Based on arg ...


Image registration is an important process in image processing which is used to improve the performance of computer vision related tasks. In this paper, a novel self-registration method, namely symmetric face normalization (SFN) algorithm, is proposed. There are three contributions in this paper. Firstly, a self-normalization algorithm for face images is proposed, which normalizes a face image to be reflection symmetric horizontally. It has the advantage that no face model needs to be built, which is always severely time-consuming. Moreover, it can be considered as a pre-processing procedure which greatly decreases the parameters needed to be adjusted. Secondly, an iterative algorithm is designed to solve the self-normalization algorithm. Finally, SFN is applied to the between-image alignment problem, which results in the symmetric face alignment (SFA) algorithm. Experiments performed on face databases show that the accuracy of SFN is higher than 0.95 when the translation on the x-axis is lower than 15 pixels, or the rotation angle is lower than 18°. Moreover, the proposed SFA outperforms the state-of-the-art between-image alignment algorithm in efficiency (about four times) without loss of accuracy.


Gallium-67 was first introduced as a tumor imaging agent by Edwards and Hayes in 1969 (1). It has subsequently gained wide popularity for the evaluation of specific tumors, and more recently for the detection of inflammatory lesions. A major limi tation in the clinical application of this radionuclide is the relatively poor quality of the images produced using available imaging devices. Recently, Anger cameras with 15-in.-diam fields have become com mercially available, and they can be equipped with three separate energy windows, a medium-energy collimator, and a moving-table attachment. Such instruments should be well suited for the imaging of Ga-67. The purpose of our study was to compare the diagnostic quality of images obtained at approxi mately equal procedure time using a conventional Ga-67 citrate imaging instrument and a large-field camera to determine whether the improved quality of the images results in more accurate diagnosis.


By using the methods of documents,video observation and statistics,this article comparatively analyses players' basic situation and the effect of applying techniques and tactics of attack and defense between China and world strong teams,and finds out some reasons why China suffer defeat in the 17th World Man Volleyball Championship,so as to provide a reference for our team to develop performance in future.


A practical workshop considering the techniques for measuring the Sound Power of Industrial sources. This workshop will explore the practical issues involved with the measurement of sound power radiated by industrial noise sources. The aim is to provide a forum for discussion on the different measurement techniques that can be used for the determination of sound power level, their accuracy and limitations when applied in industrial situations. The workshop will be of particular interest to consultants practicing in noise assessment, but should also be of interest to machinery and equipment suppliers who have a responsibility for providing information on the noise output of their products.


The synthesis of N1-substituted 2-amino-4,5,6,7-tetrahydroindole-3-carbonitriles 2 and 5,6,7,8-tetrahydropyrimido[4,5-b]-indoles 3–5 and their subsequent dehydrogenation to the corresponding 2-aminoindole-3-carbonitriles 8 and pyrimido[4,5-b]indoles 9, 11, 12, using DDQ in toluene or palladium on charcoal in 1-methylnaphthalene, is described. Palladium on charcoal proves to be a versatile reagent in dehydrogenation. The application of DDQ fails in the case of the 5,6,7,8-tetrahydropyrimido[4,5-b]indole-4-amines 4, 5, which are of special interest in regard of their affinity to the adenosine receptor. With sodium periodate, instead of the expected aromatization a new class of spiro-heterocycles is formed.


Ever since its introduction in the 1927 ICC Arbitration Rules, scrutiny of awards by the ICC Court has been a cornerstone feature of ICC arbitration. Most players involved in the arbitral process are likely to concede that a certain level of review of arbitral awards is both desirable and beneficial. Indeed, proponents among the users are frequently influenced in their choice of the ICC as the administering arbitral institution, based on their strong conviction that time and money invested in the resolution of a dispute is ultimately only well spent if awards are voluntarily complied with or at least less susceptible to be set aside. By providing a look behind the scenes of the scrutiny process, the article does away with tales of excessive intervention on behalf of the arbitral institution when reviewing and approving awards and demystifies the role played by the ICC Court throughout its close interaction with arbitral tribunals operating under the ICC Rules. The article further argues that the scrutiny process can be a highly efficient tool that helps to increase the quality and enforceability of awards rendered under the aegis of the ICC.


B5, diesel mixed with 5% biodiesel, is currently being developed to replace diesel, but there was lower engine performance. To improve the B5 properties, the addition of oxygenated additive is a better method. This research aims to study the performance of a high-speed direct injection (HSDI) diesel-engine generator at speed 3,000 rpm and different loads by using B5 blended to n-butanol and ethanol as increased to 20%. Results show that the use of B5-butanol-ethanol blends decreased engine performance as increasing ethanol; however, the release of nitric oxide, carbon monoxide, and black smoke was remarkably reduced as compared with B5. However, the use of B5 blended to 5% n-butanol, and 5% ethanol increased the electrical power to 0.33%, while electrical efficiency was added to 1.13%, and SFC was similar to B5. Therefore, this ratio can be applied with the diesel engines in the future.