Objective This project aims to perform molecular cloning of hepcidin precursor from Epinephelelus malabaricus and to construct the fusion expression vector pET-32a-hepcidin. Methods Total RNA was prepared from the liver of Epinephelelus malabaricus. The hepcidin precursor was amplified by RT-PCR with degenerate primers based on the homology of the previously reported hepcidins in teleost.The mature peptide was predicted from the deduced amino acid sequence.The cDNA sequence of the mature peptide was subcloned into the expression vector pET-32a. Results The hepcidin-like antimicrobial peptide precursor cDNA of Epinephelelus malabaricus was amplified and sequenced. The sequence of Epinephelelus malabaricus was submitted to GenBank and an accession number HM474788 was assigned.Blast analysis with sequence of DNA and the phylogenetic neighbor-joining tree of the deduced amino acid sequence suggested that sequence of HM474788 is the first reported hepcidin-like antimicrobial peptide cDNA of Epinephelelus malabaricus. The predicted mature peptide of this sequence was subcloned intto pET-32a to construct a prokaryotic fusion expression vector pET-32a-hepcidin(EM1), which was expressed in E.coli (DE3). Conclusion The hepcidin-like antimicrobial peptide precursor cDNA was cloned. The fusion mature hepcidin peptide was expressed in E.coli. The present results laid the foundation for the future functional study and application of grouper hepcidin in aquaculture.


According to the current status of the research of 3D spatial data model,a grid representation of 3D vector model is presented,which represents the 3D spatial structure by recording the key points couple on the 2D grid.This method is able to represent the case that there are many complicated faults in the space.As a use of this method,an algorithm of building the attribute model is also given.Based on the grid model,the formula and algorithm of building the surface of same arrival time is given.Therefore the algorithm of constructing accurate 3D attribute model is presented using the surface of same arrival time and well data.At last,examples are given to demonstrate the validation of the algorithm.


Sensor networks are used for a wide range of object tracking applications, such as vehicle tracking in military surveillance and wild animal tracking in habitat monitoring [1]. These applications, by their nature, enforce certain tracking quality and lifetime requirements. These two requirements, however, are two conflicting optimization goals due to the stringent energy constraints of sensor nodes.


Tensile strength of fine-grained soils has been extensively investigated by earlier researchers and several methodologies have been evolved for its determination. However, either most of these methods are not valid/applicable for a wide range of moisture contents or they involve tedious sample/specimen preparation. In this context, the methodology of determining tensile strength by employing thin films, which is available in the literature, has been found to be quite handy and useful. It has been observed that a unique relationship exists among the tensile strength, moisture content, and shrinkage characteristics of fine-grained soils. This methodology is appreciable due to its applicability to a wide range of moisture contents, comparable ease of sample preparation and testing, and the obtained results lack generalization. Exhaustive tests were conducted on fine-grained soils of entirely different characteristics and generalized relationships have been proposed between the percentage linear shrinkage, tensile strength, and moisture content (defined as liquid to solid ratio). Based on a critical analysis of the results available in the literature, the efficiency of such relationships for determination of tensile strength of fine-grained soils has been demonstrated. In the authors' opinion, such relationships would be quite useful for determining tensile strength of fine-grained soils from their linear shrinkage, which can easily be measured in a conventional geotechnical engineering laboratory.


Tom is a student in a junior high school, hut he is not very interested in his lessons. He goes to the movies at least once a week, And he especially enjoys seeing detective movies. He seems to like movies much better than books.


To solve the problem of motor control performance degradation caused by parameter mismatch in model predictive control of permanent magnet synchronous motor (PMSM), two-vector model predictive current control of PMSM based on sliding mode control is proposed. Firstly, the mathematical model of the motor in the process of parameter perturbation is analyzed and derived, and the super local model of the motor is established based on this mathematical model. Secondly, the two-vector model is built based on the new hyperlocal model. Then, a sliding mode disturbance observer is designed based on modern control theory, and the unknown part is accurately observed. At the same time, the stability of the sliding mode disturbance observer is proved by Lyapunov theory. Finally, compared with the simulation results of traditional single vector model predictive control, the results show that the improved method can effectively improve the anti-interference of PMSM when parameter perturbation occurs, and enhance the system robustness.


Bachelor thesis deals with options in involving of Legal Entity and Natural Person in Emer-gency and Disposal Works during exceptional occurrence. Thesis is divided into the theo-retical and the practical part. The theoretical part defines given issue and in the practical part are analyzed options of involving of Legal Entity and Natural Person and systems used for dealing with this issue. The analysis results in evaluation of actual state and in improvement suggestions.


Intelligent tire concept constitutes one of the approaches to increase the accuracy of active safety systems in vehicle technology. The possibility of detecting tire–road interactions instantaneously has made these systems one of the most important research areas in automotive engineering. This study introduces the use of cost-effective flex and polyvinylidene fluoride strain sensors to estimate some dynamic tire features in free-rolling and real working conditions. The proposed solution combines a microcontroller-based readout circuit for the two sensors with a wireless data transmission system. A suitable prototype was realized and first experimental tests were conducted, in the laboratory as well as on the road. The energy consumption of the wireless monitoring system was optimized. Simulated and experimental results validate the proposed solution.


Two keystones of Industry 4.0 are the increased use of autonomous robots and advanced simulation software. Human-Robot Collaboration (HRC) combines the strengths of humans and robots, opening up ap ...


For some decades now, electromagnetic radiations have not only generated electromagnetic compatibility problems but are a critical threat also for secure IC designers. In fact, these radiations can be collected, with an EM probe, to perform electromagnetic side-channel attacks (EM SCA), in order to retrieve secure data from ICs. Within this context, this paper aims to propose an industrial simulation flow able to reproduce the EM emissions of ICs during the design stage. It also proposes a technique allowing to correctly identify EM leakages prior to fabrication, considering the absence of noise in simulated traces. Finally, attacks performed with horizontal and vertical probes are compared, as well as front-side and back-side analyses, in order to demonstrate that only upper metal layers need to be considered to model the magnetic field captured by an EM probe placed close to the IC surface.


Spectroscopy has been used as a unifying theme to teach basic chemical principles and laboratory skills to talented high school students.


Female Rhizoprionodon acutus were found to mature between 62 and 74 cm total length (L T ) whereas males matured between 63 and 71 cm L T . The L T at 50% maturity was 64·3 cm for females and 64·7 cm for males. Litter size varied from one to six embryos, and was positively correlated with maternal L T . Female embryos outnumbered males by a ratio of 2·3:1. The size at birth was c. 37 cm L T . Full-term embryos and post-partum females were observed during all seasons although their occurrence was highest in spring. Spermatozoa were rarely recorded in the oviducal gland. indicating that this species does not store sperm. It was not possible to generate maturity curves for lago omanensis but it was evident that females matured by the time they reached 35 cm and males were mature by 31 cm L T . This species displayed a clearly defined reproductive cycle with parturition occurring primarily in spring, after a gestation period of c. 1 year. Maximal embryo size was 19 cm L T while maximal litter size was 24 embryos. The oviducal gland appeared to act as a seminal receptacle and it appeared that females may utilize these stores by not mating every year.


Environmental impact assessment "EIA" is a social system that prevent environment growing worse by taking measures to protect environment appropriately based on the results of investigations, forecasts and evaluations about various impacts of development before the project will be enforced.This system is applied to big projects, therefore up to now most workers in industrial enterprises have apt to interpreted that is almost unrelated with themselves except their companies will construct their new large factories. However, recently the cases setting up waste disposal facilities in factories are increasing on the paper industry in order to dispose industrial waste subsidiary produced by recycling old papers and the remains of goods. Accordingly it has been necessary to operate EIA by rules of local administrations in case of the scale of facility is large, either by rules of Waste Disposal Law revised at June 1997 in case of the scale of facility is small.That's to say EIA is being to one of imminent subjects for industrial enterprises now.So this is to introduce outline and procedure of EIA in Japan for persons who have possibility to need planning project according to the rule of EIA in future.


Cities worldwide and Vienna as well are facing an increasing pressure on space. Innovative strategies are required to tackle these challenges not only by creating new buildings but also by modernizing existing neighbourhoods. For decades Vienna counts on a gentle urban renewal approach. The question how to tackle new challenges, such as renewal towards energy efficiency, green spaces, alternative mobility or integration of multicultural lifestyles needs to be answered. The project Pocket Mannerhatten pursues the assumption that sharing building space across property outlines can offer an innovative approach for a city renewal. The spatial sharing is combined with a bottom-up-participation process and a compensation-oriented funding system. With the public funding program "Smart Cities Demo" (Austrian Climate and Energy Fund) a realization project will test the concept in Ottakring/Vienna. The multidisciplinary consortium accompanies the inhabitants realizing shared green spaces, community rooms, shared photovoltaic systems, car-sharing and Co-living apartments until the year 2021. In the future, these sharing and cooperation activities should become a city renewal strategy. Due to the slogan "who shares, gets more" and on the basis of a evaluated common good contribution not only monetary but also alternative, non-monetary incentives will be taken into account to foster urban renewal.


Ab initio density functional simulations have been performed to study the adsorption of aromatic molecules (benzene and toluene) on small Aun clusters. The calculations reveal a strong interaction between gold and π electrons of benzene, accompanied by a small electronic charge transfer from benzene to gold. We report a variety of binding conformations, with varying degrees of contact between the carbon atoms in benzene and the cluster. Therefore, the interaction between the aromatic part of molecules involved in the synthesis of fine chemicals catalyzed by gold must not be neglected, and could play an important role during some reaction


This study explores the experience of families whose member is on DNR (Do Not Resuscitate) status. Descriptive phenomenology was utilized as the philosophical underpinning of the study. After obtaining the appropriate ethics clearances, seven (7) participants were selected to be co-researchers of the study based on preset criteria. Multiple interviews were done, tape-recorded and transcribed verbatim to form the narratives of the study.Further, the approach espoused by van Manen was employed as the process of reflective explication of the narratives of the co-researchers. From the process, three themes were revealed and are as follows: (1) in a suspended reality, (2) bargaining with time, and (3) restless in a resting place. These themes are the overarching patterns of the lives of the co-researchers. Further reflection from these themes generated the essence of the co-researchers lives, encapsulated by the phrase "Hope within Hopelessness". Insights from the study suggest that the co-researchers continue to have a glimmer of hope even though the overall context of their experience is that of hopelessness since they seem to have attributed DNR with imminent death. The importance of proper and effective dialogical communication from the health care provider is further implied from the insights of this study.


Surface modification separation membrane of the present invention includes a separation membrane and a coating layer formed on the surface of the separation membrane so as to improve the stain resistance and chemical resistance of the resulting membrane, said coating layer, the thickness of the coating layer so as to suppress the decrease in the permeation flow rate of the separation membrane before and after coating of the coating layer to achieve nanoscale, the coating layer the suction force for the stable connection with said separation membrane imparting to dopamine, coupled with the dopamine by secondary binding or crosslinking, including hydrogen bonding so as to suppress the deterioration of the durability of the coating layer, said to protect the separation layer from hydrophobic contaminants on the surface of the separation membrane and a hydrophilic material to impart hydrophilicity. Surface modification method of the separation membrane of the present invention, stirring and adding the steps of introducing separation membrane for modifying the surface to the reactor, the hydrophilic material in Tris buffer dopamine is adjusted to pH range of the reaction the method comprising the formed mixed solution is added to the reactor by the steps of adding an initiator which induces crosslinking of dopamine and the hydrophilic material and the dopamine into the reactor at a predetermined temperature range, and forming a coating layer in which the dopamine and the hydrophilic material is mixed with the separation membrane by heat crosslinking at the predetermined temperature range while injecting oxygen into the reactor. .Field


Largely by historical accident, each of our states has a veritable maze of separate courts, each with its particular powers directly or indirectly derived from the state constitu tion. This atomized hierarchy of courts prevents efficient ad ministration of justice, creates issues for litigation extraneous to the merits of the case, involves successive trials and suc cessive appeals before final decision, and contributes in other ways to congestion and delay. England modernized its court structure in 1875, but in the United States it was not till the close of the first half of this century that Missouri, New Jersey, and California led the way of constitutional reform. The movement has gained considerable momentum during the past five years. Simplification of the court structure, central ad ministrative authority, and procedural reform must be accom panied by measures designed to assure the quality and inde pendence of the judiciary. Adversary election of judges in thirty-six states is a major obstacle. Here, also, Missouri led the way with a plan combining the best features of the appointive and elective methods. A handful of states have adopted variations of the plan, and arduous campaigns for its adoption have been, and will again be, conducted elsewhere.


Never mind Pop Art: has the time arrived for Pop Arch? This provocative volume offers a set of extended reflections on the evolving relationship between archaeology and contemporary Western popular culture. Loosely arranged around 12 primary thesis points, the nine chapters explore themes through which archaeology and archaeological objects hold significance within wider consumer society. Holtorf traces this 'archaeo-appeal' through the broad aesthetic experiences and metaphors that shape popular understandings of our discipline: the mysterious underground realm, the exotic perils of fieldwork, the discovery of treasures, the hunt for clues, the esoteric meanings of artefacts and monuments, and the somewhat mystical notion of authenticity. The most contentious (or possibly courageous) assertion of this volume arises out of the penultimate chapter. Starting from a general observation that different pasts hold importance to different groups of people, Holtorf offers a fresh diachronic twist to this common thesis. Different pasts, he argues, hold importance to different generations of people. Further, as every generation rewrites its history, new pasts are constantly created, with their associated material remains. As subsequent generations invest archaeological sites and objects with significance or irrelevance, the 'past' itself is remade. The past exists, therefore, as an infinitely renewable resource, as an experience of 'pastness' that may not require the protective interventions of professional conservation programs. In certain instances, the active destruction of heritage sites and artefacts may actually serve as the most culturally appropriate way of engaging with the past. To demonstrate how the past can be ethnographically renewed, Holtorf discusses (p.145) how southern African rock engravings are hammered, cut and flaked as part of traditional ceremonial encounters with these sacred sites. The ceremonial repainting of Australian rock art sites by contemporary Aboriginal communities of the north-western Kimberley region can be seen similarly to question the nature of 'destructive' versus 'constructive' relationships with indigenous heritage. Even within Western European societies, a sense of loss to some can be equally judged as a gain for others – as poignantly exemplified by the demolition and dispersal of the Berlin Wall after 1989 (p.147). Is a 'real' material past actually necessary? Pop culture overflows with examples of 'simulated environments' and 'authentic copies' replete with the alluring aura of 'pastness.' Given the dramatic advances in modern conservation technologies, the heritage industry itself embraces the blurred space between mimicry and authenticity. In a clever example of managed authenticity (p.119), Holtorf discusses the preservation treatment of a 17th century Swedish shipwreck, observing that the salvaged wooden


Gold deposits on Ni/TNAs and Ni/Ti were successfully prepared by displacement- reaction method. The result shows that the activity of all the catalysts for ethanol electrooxidation is improved by visible-light illumination and AuNi-40 min/TNAs exhibits the best long-time catalytic ability. The enhanced activity of the anodes catalyzing ethanol electrooxidation under illumination can be attributed to the plasmonic photocatalytic mechanism based on the excitation of Au, the assistant catalytic effects of TiO2 and/or Ni and the improving conductivity of the substrate.


Design and experimental results of a low side-lobe sub-array composed of dual-aperture coupled rectangular microstrip patch antenna elements, suitable for portable ultra small aperture terminals (USATs), are presented The dual-band dual-polarised antenna element achieves 21% input impedance bandwidth at S- and C-bands. Design of a series-parallel feed network and integration with an 8/spl times/8-element 30 dB sidelobe arrays with such an antenna element are also presented.


We generate stable mode-locking of different lateral modes in broad-area semiconductor lasers (BALs) by local injection of short optical pulses repeated at subharmonics of the lateral mode separation. The locking results in a persistent, periodic spatiotemporal dynamics consisting of a laterally alternating intensity modulation with a repetition rate of 3.4GHz, which can be regarded as an enhancement and stabilization of the spontaneous dynamic filamentation that is frequently observed in free running BALs.


In numerous communication applications, it is desirable to scramble the contents of the information. In addition, we seek to design a scrambling system which has maximum immunity to additive noise. This paper presents a method of analogue signal scrambling/unscrambling by means of linear periodic time-varying filters for any frequency selective noise. It is well known that linear periodic time-varying filters transform a stationary process into a cyclostationary signal. This thus spreads the spectral representation of the input process. The original part of the paper consists of using this property to reconstruct an initial band-limited process without error for any frequency selective noise.


The invention discloses a method based on MBBR for removing ammonia nitrogen from high hardness wastewater, and belongs to the field of wastewater treatment. The method adopts a MBBR technology to process the high hardness wastewater, and aims to solve the problems of difficult start of biochemical technology, bad removing effect, unstable processing effect, and easy scale generation. The technical scheme comprises the following steps: inoculation start, high hardness start, and high hardness continuous flow operation; finally the ammonia nitrogen membrane surface load is more than 0.83 gN/m /d, the ammonia nitrogen concentration is less than or equal to 5 mg/L, and the ammonia nitrogen discharge standard for city sewage factory is met. The MBBR technology has the advantages of small area occupation, simple operation, and reliable operation; does not contain a fixed bed process, so blood worms are not easy to generate; avoids the dead area phenomenon caused by uneven water distribution; and has a higher oxygen utilization rate and lower energy consumption of aeration and fluidization, compared to those of the biological fluidized bed technology.


The invention discloses an extraction method of cordycepin, which comprises the following steps of: grinding Chinese caterpillar fungus fruit bodies into a powder shape in a planetary ball milling method, wherein the particle size of caterpillar fungus fruit powder reaches about 0.1 mum so that the specific surface area of particles is enlarged, and the cordycepin can be dissolved out; promoting the dissolution of the cordycepin under an appropriate condition by utilizing an ultrasonic dissolving method to improve an extraction rate, and then removing impurities comprising coloring matter, flavonoids compounds, polysaccharide, protein and the like from the cordycepin by using activated carbons and organic solvents to obtain a cordycepin product. Compared with the traditional technology for extracting the cordycepin, by utilizing the extraction method of the cordycepin in the invention, the extraction rate of the cordycepin can be up to over 0.031%, the purity of the cordycepin reachesabove 98%, and the extraction method is convenient to operate. Therefore, the extraction method of the cordycepin has the advantages of convenience of operation and high extraction rate and purity ofthe cordycepin and creates the conditions for the effective utilization of the cordycepin.


Mangrove is a typical ecosystem that lives in areas with high salinity and tidal effects. Mangrove has the ability to absorb organic and non-organic matter produced by decomposing microorganisms derived from decomposition of leaf litter or other decomposed material. This research can provide information on the species of fungi are able to increase growth of A. marina. This research was conducted from August to October 2017 using a completely randomized design (CRD) which consists of 4 treatments with ten replicates and with two locations. Fungal species used were Aspergillus niger, Aspergillus sp. 2, Aspergillus sp. 1 and the control as a comparison. Fungi give effect to the height increase of A. marina plants with an average height of 24.64 cm on Pulau Sembilan and 27 cm in Belawan. The total dry weight of plants has an average value of 11.77 g on Pulau Sembilan and 11.97 g in Belawan. The average diameter obtained from fungi treatment on Pulau Sembilan is 0,48 cm and in Belawan is 0.56 cm. The average leaf width that occurred on Pulau Sembilan was 4.82 cm and 5.03 cm in Belawan. Aspergillus niger is the most influential fungus on the growth of A. marina seedlings.


During the summer we paid two visits to the site of a sewer trench that was being dug from Aylesbury along the London Road towards Tring. At the time of our visits excavation was being carried on in the village of Aston Clinton.


In recent years, intelligent automation in the healthcare sector becomes more familiar due to the integration of artificial intelligence (AI) techniques. Intelligent healthcare systems assist in making better decisions, which further enable the patient to provide improved medical services. At the same time, skin lesion is a deadly disease that affects people of all age groups. Skin lesion segmentation and classification play a vital part in the earlier and precise skin cancer diagnosis by intelligent systems. However, the automated diagnosis of skin lesions in dermoscopic images is challenging because of the problems such as artifacts (hair, gel bubble, ruler marker), blurry boundary, poor contrast, and variable sizes and shapes of the lesion images. This study develops intelligent multilevel thresholding with deep learning (IMLT-DL) based skin lesion segmentation and classification model using dermoscopic images to address these problems. Primarily, the presented IMLT-DL model incorporates the Top hat filtering and inpainting technique for the pre-processing of the dermoscopic images. In addition, the Mayfly Optimization (MFO) with multilevel Kapur's thresholding-based segmentation process is involved in determining the infected regions. Besides, an Inception v3 based feature extractor is applied to derive a valuable set of feature vectors. Finally, the classification process is carried out using a gradient boosting tree (GBT) model. The presented model's performance takes place against the International Skin Imaging Collaboration (ISIC) dataset, and the experimental outcomes are inspected in different evaluation measures. The resultant experimental values ensure that the proposed IMLT-DL model outperforms the existing methods by achieving higher accuracy of 0.992.


Haemophilia C is an uncommon bleeding disorder caused by XI factor deficiency. The bleeding intensity depends mainly on patient's genotype, other coagulation factors activity and platelets activity, less on XI factor activity so it is possible that asymptomatic illness reveals after anticoagulant is administered. The article describes a case of a patient with haemophilia C detected while she was being diagnosed due to recurrent bleedings during rivaroxaban and vitamin K antagonist therapy.


Locus of control/fatalism was assessed for an adolescent sample during ages 11-17 and again from ages 13-19. It was hypothesized that blacks and girls would be more external than whites and boys both during early and late adolescence. Additionally, it was hypothesized that effect sizes would be greater during late adolescence. Results obtained partially supported these hypotheses. Girls were more external than boys only during late adolescence. However, blacks scored higher in externality than whites at both time periods and effect sizes were greater during late adolescence. These findings are discussed in terms of restricted opportunities and socialization differences for blacks and girls.


Background: Individual with Duchenne Muscular Dystrophy are more prone for respiratory dysfunction. And thus the leading cause for death DMD. Objective: To find the effectiveness of inspiratory muscle training using ULTRABREATHE on pulmonary function in Duchenne Muscular Dystrophy. Methodology: The quasi experimental study was done in 5 Duchenne Muscular Dystrophy children as one group of age ranging from 9 to 16 years in wheelchair bound stage and they have been given for an ULTRABREATHE as an inspiratory muscle trainer for duration of six weeks. Outcome Measures: Pulmonary Function Test was analyzed using spirometry.
Results: Statistical analysis shows, the mean and standard deviation value is 1.5380 and .84736 in pretest and the mean and standard deviation is 1.71 and .88752 with respect to tidal volume which shows significant improvement at p value> 0.038, whereas the other components like Duration of Inspiration, Total Lung Volume/Inspiration Time, Total Lung Volume, Inspiratory Capacity, Inspiration Time/Respiration Time, Forced Vital Capacity and Forced Expiratory Volume in One second (FEV1) not showed an significant improvement. Conclusion: The study concluded that the Effectiveness of inspiratory muscle training using ULTRABREATHE on pulmonary function in Duchenne Muscular Dystrophy children showed improvement only in Tidal Volume whereas all other components not showed a significant improvement.


A study of the assumptions underlying the development of the Hertzian equations for the dis tribution of pressure and the shape of the contact areas of curved isotropic elastic solids has been made. The applicability of these equations to certain anisotropic visco-elastic fibers has been experimentally investigated and verified.


The small hermit of S. Pedro el Viejo de Arlanza, located next to the Romanic monastery bearing the same name, poses problems of cultural and chronological assignment, since, in spite of the fact that it has similar characteristics as the nearby church of Quintanilla de las Vinas considered to belong to the Visigothic period, it presents some differences when compared to the Visigothic construction type. Some of its characteristics that particularly stand out are the material, the reused Roman ashlars, as well as a vault over panaches which might not be contemporary with the original construction, but may rather belong to the baroque restoration judging by the decoration it is covered with. The analysis of the stratigraphic elements allowed the sequencing into five construction stages, namely the pre-Romanic, Gothic, Renaissance and Baroque ones. This analysis also enabled the distinguishing of the elements remaining from the first construction and their reconstruction in the original form. Yet, what it permitted above all was the formulation of a new hypothesis on the so far considered "Visigothic churches", which consists of the possibility of these churches actually being Mozarabic, built under the Islamic influence between the VIII and IX centuries.


Most reading disabilities can be traced to difficulties acquiring oral language during preschool years due to insufficient linguistic stimulation. The present 2-year project aimed to improve the literacy-related oral language skills of 48 low-income, primarily ELL 4-year-old children in local public preschool by providing for individual conversational experiences with trained university students. Their results were compared to 48 peers at two comparable preschools. Children were tested in the fall and spring on multiple measures. Throughout the year, intervention children met with volunteers each week (26 weeks) for 20 minutes to dictate personal narratives. The control group received the regular public school preschool curriculum only. The improvement of intervention children on multiple measures of oral language ability—notably vocabulary and quality of narrative—was significantly greater than that of their peers.


The key goals associated with this research includes to evaluate the assorted perspective of trajectory data warehouse and its related aspects, to perform the implementation based on novel and effective approach on trajectory data warehouse so that the effectual response can be achieved, to implement a novel or integrate the metaheuristic based approach so that the soft computing based optimized results can be achieved and to associate the applications of soft computing and related aspects so that the better results can be achieved. The prime of key goal with the parameters of objectives in this research is to explain and underline the concept of trajectory data warehouse with the analytics patterns so that the application of trajectory databases can be integrated in enormous domains. The work identify the issues related to the data warehouse, and to suggest ways of resolving them.


In this work, we study the importance of content frequency on abstractive summarization, where we define the content as "semantic units." We propose a two-stage training framework to let the model automatically learn the frequency of each semantic unit in the source text. Our model is trained in an unsupervised manner since the frequency information can be inferred from source text only. During inference, our model identifies sentences with high-frequency semantic units and utilizes frequency information to generate summaries from the filtered sentences. Our model performance on the CNN/Daily Mail summarization task outperforms the other unsupervised methods under the same settings. Furthermore, we achieve competitive ROUGE scores with far fewer model parameters compared to several large-scale pre-trained models. Our model can be trained under low-resource language settings and thus can serve as a potential solution for real-world applications where pre-trained models are not applicable.


Along with the exponentially rapidly increase in network traffic,the demands on the network resource from various applications grow.Especially,the network multimedia applications with strict QoS-guaranteed require more network resource.Network resource allocation is the final implementation of QoS allocation.The aim of QoS allocation is rational resource allocation.Therefore,efficient resource allocation is indispensable.After the problem resource allocation was discussed,we studied the resource game further.The mechanism of network resource pricing,which shows the relation of supply and demand,was presented based on bidding.Subsequently,we designed the utility function of end system and proved the existence and uniqueness of Nash Equilibrium in resource allocation game.Then,the end system's bidding strategy to reach Nash Equilibrium was discussed.At last,we further discussed the problem of resource price and the same bid in above model.The research in this paper provides the theoretic support for the coming design of resource allocation algorithm.


Transcription factors (TFs) access their DNA target sites in complex chromatin structures. Current methods to investigate TF/chromatin interactions on the genome scale (ChIP-seq, DNase-seq, ATAC-seq, FAIRE, Genomic Digital Footprinting [GDF]) are insensitive to rapid events on the molecular time scale. These approaches provide datasets that are widely interpreted in terms of long lived, static binding events. We have studied real time response element interactions for a number of transcription factors [AP1, cFos, cJun, Creb, PPARa, FoxA1, Steroid Receptors (GR, ER, PR and AR), NFkB, GRIP1, BRG1] by single-molecule tracking (using HILO microscopy) [1, 2]. Two classes of chromatin interactions are observed; fast stops (0.5-1 sec) or slow stops (6-14 sec). The majority of molecules remain unbound or exhibit fast stops, while only a small percentage exhibit slow stops. Multiple lines of evidence implicate the slow stop fraction as the functional, enhancer activating segment of the population. We also have characterized genome wide footprints for these factors, using genomic digital footprinting. Many factors do not produce footprints at response elements, even at sites with large factor densities detected by ChIP-seq [3, 4]. These results suggest that factors with short residence times are not present on chromatin long enough to produce significant protection in the DNase footprinting protocol. We have developed a novel algorithm (BigFoot) that reveals specific TF action at DHS elements even in the absence of detectable footprints. Armed with this alternate view of factor mobility, we have examined the interaction of multiple T factors at response elements in a variety of biological contexts. In breast cancer cells, we find that all the steroid receptors are highly mobile, with site-specific stops in the range of 6-11 seconds. The slow bound fraction is increased by ligand activation of the receptors, and mutation of the DNA binding domain eliminates the slow fraction. Furthermore, the estrogen receptor (ER) and the glucocorticoid receptor (GR) can each modulate the genomic binding profiles for each other [2, 5]. Thus, the receptors can reprogram the chromatin landscape to modify the overall expression profile. This phenomenon is likely to play an important role in the induction and progression of cancer. Finally, we and others have reported that T factors can be actively ejected from binding elements during ATP-dependent chromatin remodeling. Our combined findings, from three independent methodologies, support a dynamic stochastic model [6, 7] for TF function termed "dynamic assisted loading", and suggest that several classes of transcription factors, including the steroid receptors, function through highly dynamic actions at response elements.


Typhoid fever continues to ravage across the globe. It affects young children and causes higher morbidity and mortality in them. The DOMI study has added invaluable data regarding the disease incidence. The bacteria had developed resistance to the first generation of antimicrobials. Fluoroquinolones and recently third generation cephalosporins have been found to be ineffective and extremely drug resistance typhoid had surfaced in certain regions. Vaccines are an important tool in the ongoing fight against typhoid fever.


Taking A2/O technology used in a county-level wastewater treatment plant as the research object , this paper researches the improvement of effluent quality standard of a wastewater treatment plant being in the operation currently, analyzes some problems occurring in the debugging process, and puts forward some solutions.


Nutritional security is often not adequately considered and addressed in agricultural research and development (RD and by developing projects that focus on both productivity and nutrition. It may be possible to boost use of traditional vegetables through building nutrition indicators into projects' monitoring and evaluation systems, and by working with women groups and community organisations to create awareness, with training in schools and health clinics (targeting women) in areas where research projects are implemented.


Traumatic brain injuries are important causes of disability and death. Physicians use CT or MRI images to observe the trauma and measure its severity for diagnosis and treatment. Due to the overlap of haemorrhage and normal brain tissues, segmentation methods sometimes lead to false results. In this paper, we present a hybrid method to segment the haemorrhage region in trauma brain CT images. Firstly, the images are partitioned to small segments called superpixels and supervoxels in 2D and 3D spaces, respectively. Then the haemorrhage superpixels/supervoxels are grouped using their average intensity as feature. Finally, a distance regularized level-set is used to accurately delineate the exact boundary of the haemorrhage region. Evaluation is performed using the Jaccard overlap measure of our proposed technique against a modified distance regularized level-set and against the manually segmented ground truth. Our results suggest that performing level-set after superpixel/supervoxel segmentation provides better segmentation than superpixel/supervoxel intensity grouping alone and both these schemes perform better than the modified distance regularized level-set evolution method.


ABSTRACT Multilayered shell elements have proven to be highly efficient for non-linear analysis of structures. In the past, these finite elements were used with specific constitutive laws dedicated to concrete and steel. This paper is devoted to an extension of multilayered shell element to constitutive laws with internal variables (plasticity, visco-elasto-plasticity, damage). A special attention is given to the plane stress condition in both the local integration scheme of stresses and the calculation of the tangent constitutive tensor. These developments are implemented in the finite element code CESAR-LCPC. Some results of non-linear analysis of shell structures, particularly reinforced concrete, under static and dynamic loadings are presented.


We demonstrate that, if a globally smooth virtual circulation-preserving velocity exists, Kelvin's and Helmholtz's theorems can be extended to some non-ideal flows which are viscous, baroclinic or with non-conservative body forces. Then we track vortex surfaces frozen in the virtual velocity in the non-ideal flows, based on the evolution of a vortex-surface field (VSF). For a flow with a viscous-like diffusion term normal to the vorticity, we obtain an explicit virtual velocity to accurately track vortex surfaces in time. This modified flow is dissipative but prohibits reconnection of vortex lines. If a globally smooth virtual velocity does not exist, an approximate virtual velocity can still facilitate the tracking of vortex surfaces in non-ideal flows. In a magnetohydrodynamic Taylor–Green flow, we find that the conservation of vorticity flux is significantly improved in the VSF evolution convected by the approximate virtual velocity instead of the physical velocity, and the spurious vortex deformation induced by the Lorentz force is eliminated.


At the end of November the UK-EU talks were still in progress and in the absence of a deal the perspectives of short-term relations were labelled "provisional application" of interim agreements. The analysis of public opinion in times of COVID-19 pandemic reveals less attention to Brexit and a leaning to its soft alternative while believing exiting the EU to be wrong. The Johnson Cabinet was ready for no deal, having introduced the Internal Market Bill in breach of the UK-EU Agreement, but did not take measures for border control. This study shows that the reasons of the UK uncompromising attitude were dictated by economic as well as political and psychological factors. As to foreign policy the UK intends to underpin "Global Britain" with an expensive modernization of defence forces at the expense of international aid. The conclusion is that the UK is to remain the US major ally notwithstanding differences with the incoming administration.


With the rapid improvement of computer hardware capabilities and the reduction of cost, the quality of game pictures has made a qualitative breakthrough, which has reached or exceeded the picture effect of many dedicated virtual reality engines. On the basis of the design and implementation of the virtual reality 3D engine, the rendering queue management method is proposed to improve the frame rate. Based on the object-oriented design method, emitter regulator particle rendering mode, and traditional bone skin animation technology, the key structure technology in skeletal animation is analyzed, and the animation controller used to control animation playback and key structure interpolation operation is designed, which achieves the ideal animation effect. Finally, a prototype system based on engine is implemented.


The reliable classification of coin sets from different countries and counterfeit coins is an essential means of securing cash circulation. Especially bimetallic coins, such as 2-Euro coins, are often subjected to counterfeit by mixing them with coins of other countries or by imitations. In this article, a real-time embedded sensor system is proposed, based on inductance spectroscopy to characterize and identify bimetallic coins having similar geometric properties and looking similar at a first view. The system is based on inductance spectroscopy varying the penetration depth of the magnetic field in the bimetallic structure of the coin, which generally contains buried layers of other metals. The experimental evaluation shows that the bimetallic coins from different countries can be identified and classified by the use of the support vector machine, a machine learning algorithm. Experimental results showed that the system reached a classification accuracy up to 100% within a response rate of 36.62 ms per five bimetallic coins.


On the basis of every component of available common tooth paste the medicine for preventing and curing hypertension is added in and relying on the tooth paste as the carrier of hypotensor, the micro amount of hypotensor contained in tooth paste is dissolved in the saliva and quickly permeated, dispersed and adsorbed through buccal mucous, sublingual capillary net and channels and collaterals acupoints. It enters the circulation of humanbody to achieve the goal for preventing and curing hypertension. Through the clinical trial and observation, the curative effect is same as the oral level but said invention features easy, safety, quick and stable.


Ahead of this year's London Vet Show, Zoe Davies, BVA Head of Marketing, outlines the different programmes, streams and sessions that will be on offer from BVA.


The author gives two meanings to his title, Beyond Mysticism: first, that he is a philosopher concerned with basic problems raised by mysticism, not a guide describing or telling people how to engage in mystical experience; second, that mysticism, found in some degree in everyone's life, is an experience we go through and beyond, changed by it, to face the rest of our lives. He protests too much. Though the title is contrived, the book itself is a clear, straightforward interpretation of mysticism, but of the kind that analyzes, criticizes, and reformulates existing interpretations, rather than reworking the concrete data themselves. What prompts the title is the author's awareness that his


Structural evolution of the National Institutes of Health (NIH) is studied with organizational theory. NIH's transition from a functional to a market divisional structure as the agency's client biomedical research community underwent segmentation is described using as case examples the formation of two institutes. Strategies followed by professional groups seeking to influence an executive agency are illustrated. How a structure focused on servicing particularmedical constituencies may compromise the study section review of research grant applications on which NIH credibility rests is examined. NIH response to the more dynamic recent environment (AIDS, molecular biology) by recourse to matrix form is considered. Prospects for survival of the agency's unique administrative synthesis are evaluated.


Abstract : This handbook is designed to enable officers and senior NCOs to better cope with stress. Stress, its causes, and its consequences are described in the first four chapters. The remaining chapters explain important methods of coping with stress. Nutrition, aerobic exercise, relaxation, stress or management, and personal strategies (such as monitoring your heart and changing your behavior) are the methods described. Both the importance of and the implementing procedures for these methods are described.


Iluka Resources Limited ("Iluka") announces the following changes in its executive management structure. Dr Victor Hugo, after more than six years heading the company's marketing efforts world wide, will move to a new role as General Manager, Product and Technical Development. In this role Dr Hugo will lead Iluka's mineral sands centres of expertise and drive innovation in terms of the company's products and their value-in-use within specific market segments; in the technologies that underpin production efficiency and that could increase production growth; and in looking broadly to the next generation of technologies that may be relevant to success in mineral sands. Chris Cobb, formerly Managing Director of Consolidated Rutile Limited, will join Iluka in mid October as General Manager, Sales and Marketing. Mr Cobb brings to the role extensive minerals sands experience and a close involvement with major mineral sands customers, particularly in emerging markets. He will work closely with Dr Hugo to improve Iluka's product offer, technical support and market expansion activities. It is anticipated that Mr Cobb will be based in Singapore to ensure convenient access to all Iluka's major markets and customers. Peter Benjamin, currently General Manager, Exploration and Technical Services, will focus on the challenge of delivering the next mineral resources growth platform for Iluka as General Manager Exploration, without having to lead concurrently the technical services activities of the group. Exploration expenditure, previously committed to supporting Western Australian production, will over time be redirected to mineral sands opportunities in new geographies. Iluka's efforts to derive value from non mineral sands opportunities on its large tenement holdings in Australia will also be strengthened. These changes reflect the company's focus on additional value generation opportunities for shareholders and customers, beyond delivery of its two current mineral sands growth projects in the Murray Basin, Victoria and Eucla Basin, South Australia.


Modern homes are full of various domestic appliances and technological infrastructure. These technical objects could be said to cohabit with us, affecting our everyday routines, social roles, identities, emotional experiences, and our relationships with family members and other people. This research focuses on how people categorise and ascribe meanings to everyday domestic devices and in what kinds of contexts and frames this ascribing happens. My aim is to show that technological objects are not only purely functional devices, but that they form a larger part of our mundane lives and are intertwined with social relationships, emotions, and cultural categories and contexts. Furthermore, I consider how the design of future technologies such as smart homes and smart technologies could benefit from such social scientific knowledge of material culture. This study belongs to the fields of material culture studies and sociological science and technology studies (STS). The empirical data consists of 20 in-depth interviews with heterosexual couples. The main theoretical – and at the same time analytical – concepts explored in this study are those of purification and hybridisation (Latour 1993), the notion of home, and material culture. Bruno Latour (1993) writes about "purification" and "hybridization". The former term refers to a clear distinction between nature/science and society/self, while the latter describes the hybrid mixtures of objects and subjects; nature and sociality. Purification and hybridisation form the analytical thread of this study, which concludes that the process of making meaning of domestic technology follows the continuum between purification and hybridisation. The first analytical chapter of the study addresses the purification of technology and shows how people try to keep technologies in the "right" place in the normative order of things and people. It is argued that the purification is a culturally and socially preferable attitude toward domestic appliances, which stems from the technological threats conveyed by the media. When people purify technology, they talk about domestic appliances as "just technology", as something that has lower value than humanity and sociality. This "just talk" is used to position technology under human control. Moreover, people use three "discourses of control" that are part of purification in order to soften and manage the threat of technology: control of money and technical features; control of energy (sustainable development); and control of time (activity demand). People use these discourses to put the technical objects in their right place, but also to maintain and express the ethical and moral self, compared with other, less responsible consumers. The second analytical chapter explores the contradictory but co-existing process in purification, that is, the process of hybridisation. This chapter shows how the interviewees' social relationships and associations with other important people influence the meanings of domestic technologies. Domestic appliances are discussed by using a "conjugal we", which means that the partner and her/his actions are actively reflected upon as the interviewee ascribes meanings to domestic technologies. In the analysis, the interviewees' accounts, which were used to describe their own and their partners' actions concerning domestic appliances, illustrated the sociological concept of the gift and its tenet of reciprocity. In a nutshell, the interviewees attempted to balance their actions in such manner that a family member's act is returned by another act, or at least acknowledged and appreciated. As with the gift-giving, this furthers an organic and functioning social unit, that is, the family. In many cases, however, finding the balance remains only an ideal state and falters easily. For instance, one minor change in technology at home or inhabitant's life affects the everyday routines with technologies, requiring the formation and founding of a new kind of balance and reciprocity. In addition to partners, child-parent relationship and friends affect the ways in which people ascribe meaning to domestic appliances. The third analytical chapter concentrates on emotional responses to domestic technology. Emotions are often considered antonymous for rationality (and for the purification of technology), but I show that emotions are very much present when people act with technologies and refer to them when discussing their life. There is a tight relationship between the emotions of frustration/irritation and joy/pleasure, which was highly discernible in the interviews. Broken appliances or devices that are hard to use and negative feelings connected to them were given priority in the interviews as "the role of technical objects is to work". The purification of technology seems to set a "feeling rule of no feelings" when people talk about their relationships with domestic appliances. In other words, people do not feel comfortable with mixing technical objects and emotions in their accounts. However, the more they reflect on the issue, the more they start to narrate how domestic appliances may actually enhance their sense of companionship and offer entertainment and therefore positive emotions. Further, this chapter also introduces the concept of narrative and discusses how emotions are linked to domestic appliances from the point of view of narrative. Making meaning of domestic technology is pursued at three contextual levels: cultural, practical and material. The cultural level includes the strongest purification of technology, whereas at the practical and material levels people express hybridisation, mixing social elements (social relationships and emotions) with technologies. Put differently, at the cultural level, technologies are commonly talked about in an abstract and ideal sense, but at the practical level, they are ascribed meaning to within the everyday practices and social relationships, including the material outlook of domestic technologies. There is thus a continuum between the acts of purification and hybridisation, and the meaning-making differs when the view is closer to the furthest end of purification, and vice versa. The process of making meaning of domestic appliances is relational, meaning that it depends on the context in which they are discussed. As a result, there are diverse settings where people try to organise domestic appliances in their minds and practically in their homes. At the same time, it becomes clear that domestic appliances have a power to organise people, their time spent at home, and several domestic places where they operate. The final part of the research exemplifies how social scientific knowledge gathered in the study could be applied to the design of future domestic technology and smart homes. First, it is argued that the purification of technology does not merge with the idea of total automation and invisibility of ubiquitous computing, because the most important feature of domestic technology is that it should be under control. In line with purification, the users should be able to think and feel that they are the masters of domestic appliances. Total automation clashes with the idea of purification as it denotes that technologies live their own lives and are not controlled by the users, but the users are controlled by technologies. Second, intelligent agents in smart systems seem more like humans, while people have to take the role of being "thinglike", being monitored and steered. Once again, this is incompatible with the notion of purification where sociality and people are considered more valuable than technology. Third, aesthetic issues have not been taken into account in new innovations in technology, although the aesthetic appearance of objects is an important feature when devices are made part of the home environment. In addition, the concept of home is not properly understood in the design of future domestic technology. Particularly the intimate nature of homes and the privacy of familial relationships should be respected in design. Finally, the role of emotions in design is inadequately considered. Emotions are part of everyday practices with domestic appliances, and they come in many forms, which means that the measurability should not be the only view on emotions in design. All in all, the technological design of future domestic technology should widen its perspectives so that it could benefit from social scientific views. What is more, scholars in social sciences should likewise alter their views to go beyond non-empirical criticism.


The semiconductor technology continue its advnacement in 3D-IC circuit. The concept of 3D-IC introduces additional dimension in latest designs by using stack structures with through-silicon via (TSV). 3D ICs replace long interconnect in 2D ICs with TSV cells. However, optimization in terms of 3DIC is still immature in many aspects. There still exist problems in placement of standard cells and TSV cells in terms of timing optimization. In this paper, we proposed a methodology on cell placement by applying min-cut partitioning in one layer after layer assignment and address alignment constraint simultaneously. We applied Simulated Annealing to optimize timing and wirelength reduction. In final stage, a greedy legalization procedure is implemented to remove operlaps between cells and TSV cells. Experimental results show that both the wirelengths and the delay of critical paths in 3DICs are much superior compare to 2D ICs.


We prove that, if the time-independent distribution function  ( v ; r ) ?> of a steady-state stellar system is symmetric under velocity inversion such that  ( − v 1 , v 2 , v 3 ; r ) =  ( v 1 , v 2 , v 3 ; r ) ?> and the same is true for v2 and v3, where ( v 1 , v 2 , v 3 ) ?> is the velocity component projected onto an orthogonal frame, then the potential within which the system is in equilibrium must be separable (i.e., the Stäckel potential). Furthermore, we find that the Jeans equations imply that, if all mixed second moments of the velocity vanish; that is, ⟨ v i v j ⟩ = 0 ?> for any i ≠ j ?> , in some Stäckel coordinate system and the only non-vanishing fourth moments in the same coordinate are those in the form of ⟨ v i 4 ⟩ ?> or ⟨ v i 2 v j 2 ⟩ ?> , then the potential must be separable in the same coordinates. Finally we also show that all second and fourth velocity moments of tracers with an odd power to the radial component vr being zero is a sufficient condition to guarantee the potential to be of the form Φ = f ( r ) + r − 2 g ( θ , φ ) ?> .


Site-Specific Herbicide Management (SSHM) in Precision Agriculture (PA) requires weed detection in crop fields for directed herbicide application instead of spraying entire fields. This has significant economic and environmental advantages for improved agricultural practices that are essential given forecast increases in global population and food production needs. In this study, a new hybrid segmentation - Artificial Neural Network (HS-ANN) method was compared to standard Maximum Likelihood Classification (MLC) for improving crop/weed species discrimination in SSHM/PA. Very high spatial resolution (1.25 mm) ground-based hyperspectral image data were acquired over field plots of canola, pea, and wheat crops seeded with two weed species (redroot pigweed, wild oat) in southern Alberta, Canada. The very high spatial and spectral resolution image data required development of a simple yet efficient vegetation index (Modified Chlorophyll Absorption in Reflectance Index (MCARI)) threshold segmentation to separate vegetation from soil for classification. The HSANN consistently outperformed MLC in both single date and multi-temporal classifications. Higher class accuracies were obtained with multi-temporally trained ANNs (84 to 92 percent overall), with improvements up to 31 percent over MLC. With advancements in imaging technology and computer processing speed, this HS-ANN method may constitute a viable farm option for real-time detection and mapping of weed species for SSHM in agriculture.


Agriculture is the foundation of the national economy.The peasant accounts for the most Chinese population.Country is the area that economy,society,and culture are more behindhand.The three agriculture problem is the priority that Party and the country show solicitude for,to which is also the focus that the people pay attention.With society's transform,the original economy pattern is broken.The agricultural product marketplace is broadened,peasant flow amounts are enhanced,and all kinds of country contradictions are appeared gradually.As the mouthpiece of the Party,the government and the people,we should propagate the rural policy of Party and the government energetically,improve the policy theoretical level of the three agriculture unceasingly,innovate report methods unceasingly and bang the drum for the agricultural flourishing,peasant's better-off,and the rural area's boom.These are our news propagates branch inescapable duties.


The authors of [arxiv:1003.0247] neglect to consider that the source of radiation is an accelerated electron, that an emitted photon reacts, or pushes back, on the electron that releases it. This is a linear process, therefore a nonlinear Schrodinger equation is not applicable.


----------------------------------------------------------Abstract----------------------------------------------------------------The synthesised γ-TeO2nanocrystalshave been indexed in orthorhombic system with lattice energy 81.21 eV. Strain is caused by the presence of dislocations. This has possibility to have dislocations in nanoscale has little significance. The X-ray peak profile study provides peak broadening and asymmetric peak shapes and to understand the micro structural parameters for crystallite size and strain. Present work deals with systematic application of Hall-Williamson method for crystallite size estimation, and the modified Williamson -Hall p lot and the modified Warren-Averbach methods yielded physically well justified data for particle size and dislocation densities. The reflections {020}{151} and {002} have the same peak breadth and reflections while {120}{101}{200} and {122} have more or less same peak breadth. The successful application of the new procedures have indicated that even in nanocrystalline particles dislocations are present.


Environmental education aims to solve a variety of problems around all kinds of pending environmental issues. In South Korea, environmental education has developed in a dual system between school environmental education provided by environment teachers as part of the school's subject curriculums and social environmental education provided by environmental education instruction in the community outside the school. Today school environmental education has shrunk considerably while needs for environmental education in the community grow day by day. In this situation, environmental education instructors outside the school provide students with environmental education by visiting schools themselves as well as in the community outside the school, covering most of practical environmental education for students. In the area of education, there have been no full researches on environmental education outside the school and especially environmental education instructors providing the education. This study thus set out to investigate the educational experiences of environmental education instructors by selecting four environmental education instructors as research participants and conducting an in-depth interview with them in June~September, 2021.
The findings show that environmental education instructors took various chances to begin providing education and there was a high degree of diversity in the content of education and the aspects of growth through educational experiences among the instructors. These findings once again demonstrated the value of diversity that environmental education should guarantee. The environmental education instructors all made many efforts to provide the right education on all sorts of discriminating environmental matters while pursuing diversity. A high level of spontaneity demonstrated by the instructors in the process became an important foothold for their self-growth. The uniqueness of individual environmental education instructors was reflected on environmental education in various ways, and their enriched educational experiences added further diversity to their unique educational capabilities. These findings raise a need for social and educational supports to help the content and methods of environmental education develop in a productive manner in harmony with the uniqueness of environmental education instructors. It is also needed to provide institutional supports for the management of environmental education to guarantee diversity and flexibility like today and, at the same time, ensure systematic long-term education.


The EHV AC and UHV DC hybrid transmission lines on one tower differs from the traditional 500kV transmission lines, the tower width which paralleled to the 500kV line was one more time than the single circuit 500kV tower. The ion flow from 800kV transmission line spread to the air gap of the lower 500kV lines and may effect on the air gap insulation performance. In order to provide technical support to live working on the transmission line, according to the factors that influence on the switching impulse flashover performance of live working gaps, the flashover performance of "equipotential person - tower" gaps was researched with different lateral tower width which vary from 1.4m to 11.0m. In addition, the influence of ion current density on switching impulse flashover performance was investigated under the short air gaps. Experimental results show that the width of transmission tower had an impact on switching impulse flashover performance of live-working and the switching impulse flashover voltage of air gaps decreased with tower width increasing. When the tower width is 11m, the switching impulse flashover voltage of the 7.5m live working gap decrease about 14% than that of the 1.4m tower width. And the ion current density which range from 0 to 167nA/m2 had no obvious effect on the switching impulse flashover voltage of 0.80m~1.25m air gap, the live-working on the lower lever lines of hybrid AC and DC transmission system could ignore the impact of ion flow.


Field experiment was conducted with summer sesame cv. Rama with three levels of moisture regimes and five levels of growth regulators. Induced moisture stress at a particular critical growth stage (either at branching or peak flowering) resulted in higher root-shoot ratio, stomatal frequency and stomatal index whereas leaf protein content and seed yield decreased significantly. Growth regulators (CCC @ 100 and 200 mgL - 1 , BX-112 @50 and 100 mgL - 1 ) exhibited increased root-shoot ratio, stomatal frequency, leaf protein content and seed yield over control CCC @ 200 mgL - 1 was noticed to be superior in all these respects. For seed yield, interactively irrigations at branching peak flowering, capsule development and CCC @ 200 mgL - 1 performed well.


This study uses data from counties in Minnesota to investigate spending to maintain low-volume roads. Data from this investigation will allow county and local governments to make informed decisions on when it may be economically advantageous to upgrade and pave aggregate roads. The reviewed activities include maintenance grading, regraveling, dust control/stabilization, reconstruction/regrading, paving and associated maintenance activities. The expected end product is a set of relationships that can be modified to address local conditions, which will include a cumulative maintenance cost per mile. These relationships are expected to show how the maintenance costs of aggregate roads, lightly surfaced roads, and hot-mix asphalt roads vary with type of surface, age and traffic. This relationship will also be used as a tool to assist in decisions about whether or not to upgrade an aggregate road to a bound surface. Research to this point has provided enough information to give rough averages and ranges for the total maintenance cost/mile of low-volume roads. However, further research is needed to find out how counties classify their cost and whether results can be generalized.


Automated channel headwater mapping methods are reviewed and three methods are used to map a small watershed in the South Carolina upper Piedmont based on high-resolution LiDAR data. First, channels were mapped manually using crenulations on 0.6-m contours generated from the LiDAR data. Field verifications indicate the LiDAR-generated contour map is far superior to the 1:24,000 scale topographic quadrangle and the resulting network map is treated as the reference for assessing network simulations. Second, channel networks were generated using standard flow accumulation methods with three critical area thresholds representing drainage areas of 480, 800, and 1600 m2. Third, channel networks were generated using a slope-area product proportional to stream power (Ω i,j ∝ Ai,j Si,j). This multivariate method that includes hill-slope gradients improves the identification of small upland channels in steep terrain but may also introduce spurious gully sidewall channels. While all of the methods are capable of simulating fairly accurate channel networks with an appropriate drainage density, errors of omission and commission are greater with the conventional accumulation method and have an association with slope.


In November 2017, a group of farmed rainbow trout (Oncorhynchus mykiss) died in Yunnan Province, China, likely due to infection. These rainbow trout exhibited slow movement, no feeding, dark body color, exophthalmia, and occasional ulcers on the body surface. Pathogens were isolated from diseased rainbow trout livers, head kidneys, spleens, and eyes, and the strain was preliminarily identified as Acinetobacter johnsonii based on morphology, biochemical tests, and 16S rRNA and rpoB sequences. The isolated strains were highly sensitive to florfenicol, ciprofloxacin, oxolinic acid, and norfloxacin but resistant to ampicillin, doxycycline, sulfadiazine, thiamphenicol, and sulfamethazine. The selected isolate was performed for the experimental infection of rainbow trout to confirm its pathogenicity. Experimentally infected fish showed disease symptoms similar to those observed in fish naturally infected with these bacteria. Vacuolar degeneration was prevalent in the liver and spleen of diseased fish. Cytoplasm volume was very high in the lymphocytes of the head kidney. The protein structure and topology of monomeric outer membrane protein A (OmpA), outer membrane protein 34 (Omp34), and a nucleoside-specific outer membrane transporter protein Tsx (OmpTsx) of A. johnsonii were predicted by AlphaFold 2. The predicted local distance difference test (pLDDT) score was used for the assessment of structure prediction. Comprehensive analysis of antigenic determinants of the OMP family member, OmpA, contains three antigenic determinants, which are 90% similar with epitopes of A. baumannii. OmpA is a recombinant protein with 35 kDa expressed in the Escherichia coli system. Based on these findings, A. johnsonii is regarded as an emerging opportunistic pathogen in farmed rainbow trout. OmpA protein can be used as a subunit vaccine candidate molecule of A. johnsonii.


Anaplasmosis in dog is caused by Anaplasma phagocytophilum, a gram-negative, mandatory intracellular bacteria. It is transmitted through vector tick. Clinically, the acute bacterial phase is the most common in dogs. Animals with clinical disease due to acute infection often have vague symptoms of the disease, including fever, drowsiness, weakness, loss of appetite, and muscle pain. Hepcidin, on the other hand, is a peptide hormone and also plays a role as a type II acute phase reactant and regulator of iron metabolism. The aim of the study was to evaluate the relationship between hepcidin and some anemia parameters in Anaplasma phagocytophilum seropositive dogs and to learn about the use of hepcidin as a biomarker. In the study, a total of 30 dogs, 20 of which were positive for Anaplasma phagocytophilum, and 10 healthy dogs in the control group were used. In both groups, complete blood counts were performed. Hepcidin, iron, ALT, AST and ALP values were also measured in serum samples collected. When the parameters of the control and study groups were evaluated, the difference between iron, hepcidin, ALT, AST, ALP values were found statistically significant (p<0.05). As a result, hepcidin values between the two groups were statistically significant (p<0.05) and it was concluded that hepcidin could be used as a biomarker in the diagnosis of anaplasma infection in dogs with other parameters.


Due to corrosion problems,there were a series of potential hazards existing in the manufacturing processes of refining enterprises.Corrosion control is made more difficult because of the diversity of crude oil types.Therefore,systemic overall corrosion control measures were needed to ensure the equipments operation safety.Over all corrosion control measures and activities are introduced for in-service refining equipments in SINOPEC Tianjin Company,which offers relative experiences for overall corrosion control.


Analog (fp)/sup 3/ states preferentially excited in the /sup 40/Ca(/sup 6/Li, t)/sup 43/Ti and the /sup 40/Ca(/sup 6/Li,/sup 3/He)/sup 43/Sc reactions were ldentified in t he mass-43 mlrror nuclei. A simple zero-range DWBA calculation made with a cluster form factor gives good agreement with the measured angular distributions, but spectroscopic strengths deduced for mirror levels do not agree. The 3p--0h states are excited with a rather uniform cross section not strongly correlated with spins. (auth)


Yesterday was Saturday.My father,my mother,my sister and I went shopping by car.First,we went to the supermarket.We bought some fruit and food there.Then my mother bought two nice sweaters and two pairs of sports shoes for my sister and me.They are the same,because we are twinsWe like them very much.Then we went to the bookshop.There are so many


The effect of low energy (0.5 to 5 keV) Ar + beams on the surface structure and composition of monocrystalline ternary In 0.53 Ga 0.47 As and quaternary In 0.70 Ga 0.30 As 0.64 P 0.36 films epitaxially grown by MO-VPE on InP (100) substrate has been investigated. Quantitative Auger electron spectroscopy has been used with the elemental standard method taking into account the electron diffraction effects. For both semiconductors, the outermost surface layer has been found to be Ga and In enriched. In the subsurface region, the Ga enrichment is even larger, at the expense of As and In. In the quaternary film, P is depleted in the surface as well in the subsurface region. Angular Resolved Auger Electron Spectroscopy is applied to the structural study of the sputter-etched surface. The nature and spatial extension of the ion-induced surface damage have been investigated at different energies, and doses of the primary ion beam. Is has been found that the resistance to the amorphization is strongly enhanced in InGaAs with respect to GaAs.


Robiola di Roccaverano is a PDO (Protected Designation of Origin) soft cheese made with raw goat's milk, from the Piedmont region of Italy. The peculiarity of this cheese is that during the manufacturing process, a Natural Starter Culture (NSC) is added to raw milk. In this study, the viable microorganisms of technological interest, including Lactic Acid Bacteria (LAB) and fungal 21 populations were examined in samples of raw milk, NSC, fresh and ripened cheese collected from 22 one dairy by means of culture-dependent techniques. Firstly, the isolated colonies were analyzed by means of Random Amplify Polymorphic DNA-PCR (RAPD-PCR) and strains with similar 24 fingerprint were clustered together. Further, representative isolates of each obtained, corresponding to 9 different bacterial species or subspecies. Concerning mould and yeast 28 isolates, 5 species were found which coincided with 5 RAPD-type. Observing the strains isolated in 29 the study, Lactococcus lactis was the most prevalent species in raw milk and NSC samples. Instead, 30 Leuconostoc mesenteroides was the predominant species identified in 5- and 15-days cheese isolates. 31 Furthermore, while only these two species were detected in NSC, in raw milk and cheese 32 Enterococcus and Lactobacillus genera were respectively found. Concerning the mould and yeast 33 isolates, in NSC Kluyveromices spp. was mainly found, instead, in cheese samples representative 34 species were Geotrichum candidum and Yarrowia lipolytica . Finally, the raw milk and cheese safety 35 were evaluated and the samples complied with the standard required by the European Commission 36 Regulation 2073/2005.


An investigation on Ready- to-serve in ginger blended pomegranate was undertaken during the year 2013-2014 in the Post-Harvest Laboratory, Department of Horticulture, Dr. Panjabrao Deshmukh Krishi Vidyapeeth, Akola with the objective to study the chemical changes and sensory qualities of ginger blended pomegranate ready-to-serve beverage under different storage conditions and to find out the better storage condition for ginger blended pomegranate ready-to-serve beverage. The experiment was conducted in Factorial Completely Randomized Design (F.C.R.D.) with six treatments comprising of different proportions of pomegranate and ginger i.e . 10:01, 10:2, 15:01, 15:2, 20:01 and 20:02 in the RTS. The blended RTS was prepared by maintaining 15 °B T.S.S., 0.3 per cent acidity with 100 ppm sodium benzoate as preservative. The observation in respect of chemical analysis and sensory evaluation were recorded periodically. Sugars of pomegranate RTS was increased with increased storage period irrespective storage methods under study. Minimum change in sugars was observed in refrigerated storage condition, while maximum change was recorded in at ambient storage conditions. Further the taste, colour flavour and overall acceptability scores decrease continuously decrease with an advancement of storage period. The ginger blended pomegranate RTS stored at refrigerated storage condition recorded more acceptable score, while the beverages store at ambient storage were found to be less acceptable.


Surface-normal photonic switches are very attractive because they can switch and process a number of broadband optical signals simultaneously. Recent progress on surface-normal switches based on liquid crystals, MQW-modulators and surface-emitting lasers is reviewed in the context of system applications for optical interconnections and photonic switching networks.


ABSTRACT Introduction: Yoga practice is an activity recently implemented in the content of school physical education to guide students to participate actively in sports activities. Its impacts on the body and psychological health of students are constantly evaluated. Objective: Study the effect of yoga practice on the heart rate and cardiopulmonary capacity of obese students. Methods: 40 obese students from a high school were selected as volunteers for the experiment, randomly divided into an experimental group and a control group, with no change in location or duration of intervention between the groups. The students in the control group participated in regular school activities during physical education classes, while the experimental group performed yoga training during the same schedule. The duration was eight weeks. Results: After the experiment, the heart rate and lung function indexes of the students in the experimental group showed a statistical increase, without significant weight changes, but body fat and visceral fat were reduced, with improvement in their body composition and muscle lines. Conclusion: Yoga practice reflected a positive effect on the physical performance of obese students, positively impacting on heart rate and cardiopulmonary resistance of the students. Level of evidence II; Therapeutic studies - investigation of treatment outcomes.


Over the last decade, multi-tasking learning approaches have achieved promising results in solving panoptic driving perception problems, providing both high-precision and high-efficiency performance. It has become a popular paradigm when designing networks for real-time practical autonomous driving system, where computation resources are limited. This paper proposed an effective and efficient multi-task learning network to simultaneously perform the task of traffic object detection, drivable road area segmentation and lane detection. Our model achieved the new state-of-the-art (SOTA) performance in terms of accuracy and speed on the challenging BDD100K dataset. Especially, the inference time is reduced by half compared to the previous SOTA model. Code will be released in the near future.


Krukenberg tumor is an interesting and rare clinical entity. It is an uncommon metastatic tumour of the ovary with transcoelomic spread and accounts for 1-2 % of all ovarian tumours. Stomach is the most common primary site, but other organs can serve as a primary site. Accurate diagnosis of Krukenberg tumor requires thorough endoscopic and histopathological examination to exclude primary ovarian tumors. Herein, we report a rare case of a 36 year old woman who presented with bilateral ovarian masses. Total hysterectomy with bilateral salpingo-oophorectomy was performed. Histopathological examination confirmed the diagnosis of Krukenberg tumor.


The aim of the paper and of a wider project is to translate main notions of anabelian geometry into the language of model theory. Here we finish with giving the definition of the etale fundamental group $\pi^{et}_1(X,x)$ of a non-singular quasiprojective scheme over a field of characteristic 0.


This side-chain liquid crystal polymer comprises: two or more structural units represented by general formula (I); and a liquid crystalline structural unit having a side chain including a liquid crystalline moiety, wherein the two or more structural units represented by general formula (I) include a structural unit (a) represented by general formula (I), and a structural unit (b) that is represented by general formula (I) and that is different from the structural unit (a) in the number of carbon atoms in a linking group represented by L 1 or L 1' . (The symbols in general formula (I) are as defined in the description.)


Based on a research in the women organizations of the professional women in the labor union of Fujian province,we discovered their special accomplishment and contribution,especially on the investment for the capital of manpower of the professional women.However,there are still short of a system for a long-term developing as well as a pertinence and balance of investment.Our countermeasures and suggestions to the inadequate are: Firstly,we must clarify the aim and to lay down the long-term investment project in a rational way;Secondly, we have to deepen the research and to classify the operations to raise the effectiveness of the investment;The third,we should bring into our own superiority using social resources to carry out the multi-directional investment.


To the Editor: We read with great interest the November 1, 2006 article by Balak et al. ([1][1]) reporting that the epidermal growth factor receptor ( EGFR ) D761Y mutation was a "novel secondary mutation" that appeared in a metastatic brain lesion after the acquisition of gefitinib resistance.


The two operations which have the most influence on the entry of youth into the labour market (the regulation of vocational training supply and the recruitment strategies of firms) are tied into specific territorial frames. Both those operations are organized via various policy instruments, coming also in different territorial frames. Three dimensions of territoriality are to be distinguished from one another. These are related to the various stages of engagement with these instruments by the administrative, political or social actors and by the final addressees of these policies: the young people and the firms. The analysis of these territorial dimensions is grounded in the study of the steering of vocational training provision in the Picardy region and of the recruitment practices of the retailing firms of this same region.


Sri Lanka is no stranger to calamities, man-made or otherwise. It has weathered a civil war of thirty years, the Boxing Day tsunami and the Easter Sunday bombings just a year ago. The country has paid a colossal price in human lives, material losses and attendant adverse socio-economic consequences. The COVID 19 pandemic, declared by the World Health Organisation (WHO) 7 weeks ago, is the latest, and probably one of the gravest challenges to the nation in general and the health services in particular.


ABSTRACT Gender diversity (GD) is an issue that must be addressed for the sustainable development of businesses. Research is lacking on GD in the sustainability management of supply chains (SMSCs). This study addresses the potential impact of GD on SMSCs. A literature review methodology is used to review academic and professional articles over three decades. The findings show that some studies have examined GD and supply chain management (SCM) but the focus has tended to be on the challenges encountered by women in SCs, such as women as victims, but not women as potential change actors. In contrast, sustainability management literature invokes the importance of GD and the specificities women managers can bring to firms' performance. A research agenda is proposed in this study by combining outcomes from both fields. It implies there is an important space to fill, especially concerning the environmental and social impacts GD may have on SMSCs.


The field of Human Computer Interaction (HCI) has traditionally focused on the usability of a system, but as increasing numbers of interactive products become entwined in our daily lives, so does the opportunity to understand user impacts that reach beyond usability. In particular, interaction design, a subdomain of HCI, expands the focus of HCI by looking at the aesthetic impacts a system may have on user emotions. Curiosity is one such emotion that tends to induce information-seeking and motivational behaviors. An experimental study was undertaken to determine whether an interactive, front-end graphic that incorporated curiosity principles in its design would sufficiently pique a participating university faculty's curiosity to interact with the graphic, and thereafter, with an existing platform named George that was developed to motivate faculty to engage in collaborative behavior. George includes capabilities for creating and storing individual faculty trading cards that include the faculty's photograph, personal interests, research interests, and publication domains. The experimental graphic provided interactive capabilities to incrementally reveal segments of the photograph and to acquire information about the faculty's research profile. The number of a study participant's interactions with the graphic was limited by software. The data collected included the location and frequency of interactions with the graphic, and whether participants ultimately accessed the George platform. Statistically significant evidence demonstrated that the curiosity-provoking principles motivated interaction with the graphic, and that participants were also motivated to access George. DESIGN FOR CURIOSITY iv


The A130 Bypass project comprises a dual carriageway road from the A12 to the A127. Because of the scheme size, it was decided to develop it in two sections so as to improve the acceptability in the TPP process: the Northern section from the A12 to the A132 and the Southern section from the A132 to the A127. The justification for the scheme is that it would: (1) provide high quality improvement to this section of the strategic primary route; (2) provide environmental relief to local communities on the existing route; (3) reduce rat running on unsuitable roads; (4) provide South East Essex with the A12, an alternative high quality access route to East Anglia and the Haven Ports for its economy and population of around 500,000; and (5) provide with the A12 and A13, an alternative high quality access route from Essex to East Anglia to the Thames crossings. The scheme has been submitted a number of times to the DoT for funding through the TPP process. Whilst the DoT have accepted the merits of the scheme and its high net economic benefits, it has not been able to afford the high costs of the scheme. Essex County Council has continued to rank the project its highest priority transport infrastructure improvement and has explored alternative means of achieving the scheme including DBFO and PFI. For the covering abstract, see IRRD E100685.


The organization of the two volumes is surprising at first sight, but logical. Volume I describes the geographical environment of the subcontinent ; Volume II concerns itself with the use made of this environment by man, and with the peoples who live within it the Europeans, the Asians, the Colored, and the majority Bantu. The second volume stands by itself and, except for geographers, will probably be used much more extensively than the first volume. The seventy-odd pages in Volume II which deal with the peoples of the subcontinent are particularly useful in providing specific information on the ways in which these groups earn their livelihood, their wages, and their standards of living. From the Katanga area of the Belgian Congo and the Northern Rhodesian Copperbelt through the Transvaal and the Orange Free State to the northern Cape Province of South Africa lies the richest mineral belt yet discovered in the world. Yet the richness is heavily counterbalanced by the multiplicity of the problems of this area. The exploitation of the minerals, and the development of secondary industry in the Union (where Africa's only industrial revolution is in full swing) have placed vast demands on a resource, water, which we take for granted in North America but which is the great limiting factor in southern Africa. Still more complex are the racial problems arising from the intermingling in the economic process of peoples in widely differing stages of development. Dr. Welling-


"It is important to realize that only living things and their inanimate extensions undergo semiosis, which thereby becomes uplifted as a necessary, if not sufficient, criterial attribute of life" (Sebeok 1994: 6). A statement as firm as this — the difference Sebeok makes — asks for attention. Moreover, both in biology and in semiotics, relating life to semiosis makes a big difference. Its role can be seen in the context of major paradigms in scientific approaches to living nature over the ages. This lecture is about the semiotic approach in biology. In other words — about the role of semiotics for biology, or about a semiotic theory of life, a semiotic biology — biosemiotics. Despite the fact that under any circumstances semiotics and biology would have found each other some day, sooner or later — because this is just a "necessity" of the development of human knowledge — despite this the whole story and the entire situation today would not be as it is without the work and role of Thomas A. Sebeok.


In this article, we adjust the Kuk randomized response model for collecting information on a sensitive characteristic for increased protection and efficiency by making use of forced "yes" and forced "no" responses. We first describe Kuk's model and then the proposed adjustment to Kuk's model. Next, by means of a simulation study, we compare the efficiency of the adjusted Kuk model relative to the pioneer Kuk model while maintaining at least equal protection of respondents.


This paper presents a control law that time-scales reference trajectories of dynamical systems, yielding arbitrary velocities in arbitrary time. It is shown that, for unforced (passive) reference trajectories, constant time-scaling results in a potential energy-shaping control. Application to walking trajectories of bipedal robots is shown, extending the use of the control beyond purely continuous dynamical systems to a class of hybrid dynamical systems with discontinuities that are linear in velocity. Two biped models are used to demonstrate the control law: for the compass-gait biped, we illustrate time-scaling of a passive reference trajectory; for the biped with a torso, we show time-scaling of a semi-passive reference trajectory.


PURPOSE
To investigate the impact of diabetic macular ischemia (DMI) on visual acuity (VA), through the analysis of novel fluorescein angiography (FA) parameters.

METHODS
Data were retrospectively collected over a 6-month period. DMI severity was graded using Early Treatment Diabetic Retinopathy Study (ETDRS) protocols. Custom software was used to quantify areas of the foveal avascular zone (FAZ), and of capillary nonperfusion over the papillo-macular nerve fiber layer bundle, and temporal macula, and associations tested with VA.

RESULTS
A total of 488 patients with type 2 diabetes mellitus and FAs of sufficient quality to allow detailed quantitative analyses were included. ETDRS-DMI SEVerity was graded as: none, 39.7%; questionable, 18.4%; mild, 25.2%; moderate, 11.0%; and severe, 5.6%. Median FAZ areas were 0.19 mm(2) (interquartile range [IQR], 0.13-0.25); 0.25 mm(2) (IQR, 0.18-0.32); 0.27 mm(2) (IQR, 0.19-0.38); 0.32 mm(2) (IQR, 0.25-0.54); and 0.78 mm(2) (IQR, 0.60-1.32), respectively, and were significantly different between all grades (P < 0.002), apart from "questionable" versus "mild" grades. Significant association of VA to FAZ area was observed only in the moderate (β = 0.406, SE = 0.101, P = 0.001) and severe (β = 0.299, SE = 0.108, P = 0.006) subgroups, but not in milder ETDRS-DMI grades. A strong association with VA was observed in cases with papillomacular ischemia (β = 1.123, SE = 0.355, P = 0.005), independent of FAZ size or the presence of macular edema.

CONCLUSIONS
Diabetic macular ischemia is associated with reduced VA in eyes with moderate to severe ETDRS-DMI grades of ischemia but preserved in milder grades. In addition, we describe the independent association of papillomacular nerve fiber bundle ischemia with reduced VA.


Antibiotics resistant capacity when pathogens are develops inhibition mechanisms in opposition to different antimicrobials that formerly sensitive. Different kinds of pathogens can advance resistance mechanisms or strategies via more than a few ways, such as natural or acquired. Innate resistance would be going on when pathogen can protects themselves from any drugs, this was once may be due to the capsules have low permeability to the pathogens. Additional reasons may be due to variations in the chemical compositio drug and the pathogens membrane structures. Acquired resistance potential the development of resistance of antibiotics that can be appear due to exceptional reasons, in this case the pathogen  can beforehand inclined the tablets but through procedure they advance resistance mechanisms. The plasmids transformation, transduction, conjugation and transposition are the most common ways in which bacteria or pathogen can strengthen the resistance mechanisms.


During my professional career as a clinician for nearly five decades, I have come across several instances where I felt that my role as a clinician has been a failure. I consider these instances as critical incidents that have molded my clinical practice and hopefully made me a better clinician. In this paper, I will discuss about few of those situations, narrating the experience that I lived through, highlighting where I think I went wrong and how best we clinicians should perform under such circumstances. I have divided the paper into lapses in history taking, lack of completeness in physical examination, premature closure in making a diagnosis and inadequacies in treatment, and each of these will be illustrated using a real-life scenario that I have lived through. As clinicians, we should strive for zero error, but we human beings are imperfect and often have room for improvement in the ways we act and react. In your clinical practice, irrespective of whether you experience critical incidents or not, it is always better to reflect how you could have treated each patient you have seen, better and make your practice more reflective rather than thinking in a stereotyped manner.