Presentation of etymological information in dictionaries varies widely, making it difficult to propose a standard form of encoding this information in the process of digitization. The following proposes an extension of the TEI P5 standard for encoding texts using XML, wherein a new element is able to nest recursively, thereby allowing the XML format to match that of a language family tree. Problems of reconstructed proto-forms, loanwords, and language grouping are further discussed.


Electric vehicle technology is an effective solution to environmental problems, but at the same time, e-vehicles are challenging from a metrological point of view. Range and efficiency are crucial for performance issues. Metrology should address those issues in order to provide valuable tools for designers and final customers. This paper deals with the realization and testing of a test bench to metrologically characterize electric vehicle main components in the energy conversion chain, from the mains to the wheels. The test bench has been realized for educational purposes during the class "Measurements for e-mobility and smart energy systems" at the University of Campania "Luigi Vanvitelli" (Aversa, Italy), and it can be used to estimate the energy efficiency of the whole power train or its components in the various operating conditions.


Multi-excitation modal analysis was used in large structures,such as,bridge,construction,aerospace industry.A survey of theory and application in modal parameter identification with multiple-excitation was presented based on response data.Then,a deep discussion on techniques of modal parameter identification with multi-excitation under different assumptions of excitation signal model:stationary random excitation and non-stationary random excitation was given.At last,the development prospect of measurement methods for parameter identification with multiple-excitation was summarized.


The Interpretation of the measured, very weak magnetic fields generated by the electrically active organs requires special numerical techniques for localization and reconstruction of the sources. The state-of-the-art of the development of such methods is defined by inverse solution techniques which can reconstruct equivalent dipolar sources within more or less realistically shaped volume conductors. Due to the nonuniqueness of the inverse problem, source reconstruction is only possible under restricted conditions regarding volume conductors and sources. The use of physical phantoms might be helpful to validate the known inverse methods, to improve them or to develop a new one. In addition it is useful to perform magnetic and eleclrical measurements with physical phantoms under well-defined conditions to validate the models and to calibrate the measuring Systems. One advantage of physical phantom measurements over pure Simulation studies, is that the former take into account real world influences such äs environmental noise and 3-D positioning errors, thus providing an error estimation of the entire source reconstruction procedure. Current topics of research in bioelectromagnetism are algorithms for reconstruction of extended current sources by solving the inverse problem. The phantoms enables us to perform studies for testing different measuring Systems and validating the localization algorithms. In this paper we present an overview of the four different phantom models, conductivity comparlments and five source modules developed in our group within the last three years. The phantoms were filled during measurements with NaCl solution. A special polymer membrane was used to model different conductive compartments in the thorax. The simplest source model is the current dipole which is a good approximation for focal sources. We developed five special source modules, that can be interchangeably fixed on a ground plate at a defined position at the interior back of the thorax phantom or in the head model. Four of the source modules consist of a set of multiple dipoles. The other module consists of an· extended current source (butterfly source model) with variable position and orientation. Magnetic Resonance Images (MRI) data of the physical phantom models were used to obtain geometric description of the volume conductor for the Boundary Element Method (BEM). Tank model


This paper reviews two of the major sociological theories of modernization, the consensus and conflict perspectives. These two theories are used to analyze some aspects of the economic and political situation in Chile. The international stratification approach is then presented as a third theory. Based upon criteria developed during the critique of the consensus and conflict theories, it is argued that the international stratification paradigm offers a synthesis of these two approaches which may be able to fulfill the requirements for a comprehensive sociological theory of modernization. From the classical period to the present sociologists have been con cerned with social change and development. Comte, Spencer and others, under the influence of Darwin, were particularly concerned with social progress. Social progress has been defined as "attempts to trace the evo lution of specific social forms or entire societies from some earlier, less


The purpose of this paper is to provide the latest results on nonlinear vibrations of a composite circular plate subjected to mechanical and thermal loadings. A model of the plate is based on the Mindlin theory and then extended by taking into account a nonlinear displacement filed (due to large plate oscillations) and acting heat flux which leads to heat propagation through the plate span.


Conjoint measurement generally is used to assess utilities for a few discrete attribute levels. An important practical application of such utility assessments is the prediction of the overall value of alternative new product concepts. If these product concepts are defined as combinations of attribute levels other than the original discrete levels presented to the respondents, linear interpolation commonly is used to predict utilities for the new attribute levels. However, linear interpolation may lead to poor predictions and the consequent choice of the wrong new product to introduce in the market. Therefore, the authors present an alternative to linear interpolation: the estimation of a utility function. An analytical procedure and some numerical results are provided to indicate the superiority of the utility function approach for the prediction of attribute utilities. The market share implications of improved utility prediction are discussed.


A recent paper [1] proposes using the Davies tree configuration as a processing structure for adaptive arrays. The advantage of doing this is that fewer computations are needed for adaptation. The purpose of this correspondence is to point out that the performance of the Davies tree is suboptimal. It does not, in general, produce maximum output SINR (signal-to-interference-plus-noise ratio) from the array.


SIR, I have read with great interest the correspondence between Phillips (1973) and Dobree & Taylor (I 973). Phillips correctly warns of the dangers of both observer and patient bias. "The desire for successful outcome is felt so strongly by both patient and investigator that objectivity cannot be guaranteed" (Cox, I968). Observer bias, which can work either for or against the experimental treatment, can in the case of visual acuity, as Phillips points out, be prevented by keeping the refractionist unaware of who was treated and who was a control. Sham procedures are not always ethically justified, but this does not relieve the clinical investigator of the responsibility of taking patient bias into account. Patient bias in visual acuity can be counteracted by cajoling the patient to a maximum effort and by attempting to measure the magnitude of any residual bias (Aiello and others, in press). Alternating patients is not satisfactory a substitute for randomization because the investigator knows whether a treated subject or a control is coming next. Having this knowledge he can elect to admit or reject the next patient, and the resulting bias can damage the integrity of the study. Symmetrical eyes provide greater precision of the estimated treatment effect in a treatment comparison study than asymmetrical eyes. However, symmetry of paired eyes is not necessary for randomization. If it were, then one could not randomize unpaired eyes (if eyes were the sampling unit) or unpaired patients (if patients were the sampling unit). Many clinical trials in which heterogeneous patients remained unpaired have been carried out successfully. The main purpose of randomization, which it accomplishes without sacrificing precision, is to eliminate selection biases. Precision can be increased by pairing (Ederer, I973) or stratifying (Hill, I962), and also, of course, by increasing sample size. Dobree and Taylor say that they excluded a statistical analysis because "it is not known if the disease existed in comparable severity in the treated and untreated cases; many of the local and general factors influencing the prognosis are still unknown". I believe it is safe to predict that all the prognostic factors will never be known. But knowledge of prognostic factors is not necessary for the design of a meaningful clinical trial. Both the efficacy of the Salk vaccine for preventing poliomyelitis and the inefficacy of antihistamines in treating the common cold were determined by randomized, double-masked studies without much, if any, knowledge about prognostic factors. If a statistical analysis cannot be justified, then no generalization of Dobree and Taylor's finding, "Using the parameters of the retention of the visual acuity, the treated cases fared better than the control cases . . ." is warranted. For, as Weaver (I960) said, "Statistical evidence is, in essentially all nontrivial cases, the only sort of evidence we can possibly have". I am deriving more than a whit of satisfaction in returning across the Atlantic lessons in experimental design and statistical analysis taught by Fisher (1935), who discovered randomization as the nonpareil method of preventing bias in allocating treatments, and Hill (I962), father of the modern clinical trial. Yours faithfully, FRED EDERER Head, Section on Clinical Trials and Natural History Studies, National Eye Institute NATIONAL INSTITUTES OF HEALTH, BETHESDA, MARYLAND 20014 USA March 2I, I974


Recent work in the district of Kaupō, Maui, has demonstrated the presence of a highly intensified dryland agricultural system, extensive residential sites and a range of ceremonial structures that include some of the largest temples ( heiau ) in the Hawaiian Islands. In this paper I discuss the ritual sites of Kaupō and how their placement on the landscape demonstrates a unique expression of elite power. Using formal architectural features to define two basic classes of ritual sites, I show that the nutrient-rich core of the district is bounded on either side by a network of monumental temples, effectively proscribing the highly productive interior. In contrast to these major heiau around the exterior, the interior of the district is dominated almost exclusively by small, relatively simple ceremonial spaces. Understanding the differential distribution of the ritual structures in Kaupō offers insights into how pre-contact Hawaiian rulers sought to centralise and control highly productive regions.


Pure aluminum coating with a nanoscale twin structure (NT Al) was successfully deposited by using a magnetron-sputter technique. The corrosion behavior of the NT Al was investigated and compared with that of cast Al in an aqueous acidic chloride solution by using potentiodynamic polarization and an electrochemical noise technique. The results indicated that for NT Al, both the cathodic and anodic reaction processes were greatly inhibited, the corrosion potential shifted to a more positive value, and the corrosion current density apparently decreased. The NT structure affected the pitting behavior of pure aluminum in two ways based on the stochastic analysis of the electrochemical noise data: (i) the formation rate of metastable pits was accelerated and (ii) the growth of the stable pit was impeded. This leads to the enhancement of the pitting resistance for NT Al coatings.


Since the time when Comrade Mao Zedong and the party's Central Committee, summing up the experience and lessons of Chinese and world history, proposed the correct policy of "letting a hundred flowers bloom and a hundred schools contend" as a general guideline for the promotion of a flowering in science and arts, academic circles throughout the country have raised a number of scholarly questions and published different opinions. There have been many healthy and vibrant developments in the academic style of free discussion and debate, reflecting the tremendous effect of this correct policy.


Proton exchange membrane water electrolysis (PEMWE) technology is especially advantageous for green H2 production as a clean energy vector. During the water electrolysis process, the oxygen evolution reaction (OER) requires a large amount of iridium (2‐3 mgIr cm−2) as catalyst. This material is scarce and expensive, representing a major bottleneck for large‐scale deployment of electrolyzers. This work develops an anode with 10‐fold reduction of Ir loading (0.2 mgIr cm−2) compared to what it is used in commercial PEMWE for more than 1000 h. An advanced catalyst based on an Ir mixed oxide (Sr2CaIrO6) is used for this purpose. Transmission electron microscopy (TEM), X‐ray photoelectron spectroscopy (XPS), and X‐ray absorption spectroscopy (XAS) analyses show that the unconventional structure of the reconstructed catalyst can contribute to the reduction of Ir in the catalyst layer. The reconfiguration of the ionomer in the catalyst layer is also observed by scanning electron microscopy (SEM) and atomic force microscopy (AFM), results in almost the full coverage of the catalytic layer with ionomer. The results presented herein demonstrate that it is possible to achieve high performance and stability in PEMWE with low Ir loading in the anode without showing significant degradation.


BACKGROUND
Fetal structural abnormalities, particularly limb reduction defects, have been reported after early hypoxic injury, such as chorionic villus sampling (CVS) before 66 day's gestation.

CASE
We present a case of uterine curettage in early pregnancy associated with the subsequent prenatal diagnosis of fetal oromandibular limb hypogenesis syndrome.

CONCLUSIONS
This case is consistent with previous hypotheses concerning the role of hypoxic trauma in inducing fetal structural defects in early pregnancy.


Numerous studies into the links between interpersonal trust and confidence in state institutions have been conducted since Putnam made the study of trust popular in the early 1990s. As might be expected, both interpersonal and institutional trust tend to be strongly correlated at the individual and the aggregate country level. However, there have been no attempts to determine whether (i) interpersonal trust results from trust in political institutions, (ii) whether the reverse is the case—confidence in government is a precondition for the development of individual trust, or (iii) there are purely reciprocal associations between these attitudes that would appear empirically as a lack of causality. Using data from the European Social Survey 2010 we test these three possibilities using a recursive model.


A study of magnet schools revealed that they have become a significant part of the nation's efforts to desegregate schools. Most magnet schools are in urban areas and offer a distinctive curriculum. School districts began employing mag-at schools in the 1970s to help desegregate schools. The federal government has assisted magnet schools with funding. This report is designed to study magnet schools, their role in desegregation, and their impact on educational achievement. Telephone interviews were conducted with educators at 600 school districts nationwide. The study revealed that magnet schools are increasing in number and attracting more students, including minority students and students from outside the school's immediate area. They offer a wide range of distinctive programs. Many magnet schools use money from the federal Magnet Schools Assistance Program to help set up and maintain their programs. This report contains six sections: an introduction, the growth of magnet school programs, implementation of magnet schools and magnet programs, federal support for magnet programs, nonmagnet schools and programs of choice, summary of findings and directions for further research. Appendices A-C include study samples, data, and detailed tables as well as the survey instruments. A glossary is also included. (Contains 15 rezerences.) (JPT) *********************************************************************** * Reproductions supplied by EDRS are the best that can be made * * from the original document. * *********************************************************************** Educational Imiovation in Multiracial Contexts: The Growth of Magnet Schools in American tducation ( ontract No 1 C90043001 *4"*? U,S. DEPARTMENT Of EDUCATION Office of Educational Research and tmprorarnent EDUCATIONAL RESOURCES INFORMATION CENTER (ERIC) 14/f°fis document has been reproduced as recetvol from the person or organization onthnating 0 ;knot changes have been mad* to unprove reproduction Quality Points ot vow of opinions Stated in this doeth mint do not necessarily represent offiCial OERI position or policy Prerare'd f Or the U 1.erariffleht ot I ducanon under ()whir. t merican Institutes for Research: Palo Alto, California U (-; DEPARTMENT OF EDUCATION 411111 OFFICE OF THE UNDER SIVRIEAR) A Educational Innovation in Multiracial Contexts: The Growth of Magnet Schools in American Education Lauri Steel, AIR Roger Levine, AM Contract No. LC90043001 Prepared for the U.S. Department of Education under contract by: American Institutes for Research, Palo Alto, California 1994


This paper proposes a unified performance analysis framework of asymmetric dual-hop radio-frequency/free-space optical (RF/FSO) transmission systems. The generalized independent and identically distributed (i.i.d.) <inline-formula><tex-math notation="LaTeX">$\alpha -\mu$</tex-math></inline-formula> distribution is considered for each branch in the RF link, whereas the FSO link is assumed to experience Málaga (<inline-formula><tex-math notation="LaTeX">$\mathcal {M}$</tex-math></inline-formula>) fading with pointing error impairments. With amplify-and-forward (AF) and decode-and-forward (DF) relaying, the imperfect channel state information (CSI) of both links is considered. For the considered system, we first derive exact and novel analytical expressions for the probability density function (PDF) and cumulative distribution function (CDF) of the end-to-end signal-to-noise ratio (SNR). Furthermore, we obtain key performance metrics such as outage probability (OP), average bit-error-rate (ABER), and effective capacity (EC). The important effects of channel parameters on the system are disclosed from mathematical analysis and are further validated by Monte-Carlo simulations.


Thank you very much for reading basic guide to data communications. As you may know, people have look hundreds times for their chosen readings like this basic guide to data communications, but end up in malicious downloads. Rather than enjoying a good book with a cup of tea in the afternoon, instead they cope with some harmful virus inside their desktop computer. basic guide to data communications is available in our book collection an online access to it is set as public so you can get it instantly. Our book servers hosts in multiple countries, allowing you to get the most less latency time to download any of our books like this one. Merely said, the basic guide to data communications is universally compatible with any devices to read.


This paper describes a generalized phase shifting interferometiy where the reference phase instead of being set to predetermined values is directly evaluated at each time the interference fringe data are read. The evaluation of the phase shifted is achieved by introducing the FF1'' method for analyzing additional straight fringes on the interfering plane. The repeatability in the measurements of an optical surface is V500 when the generalized algorithm with 8 data acquisitions is used. 1.


1. A method of producing a protein in cell culture comprising the steps of: culturing mammalian cells that contain a gene encoding a protein of interest, wherein the gene expression is carried out in cell culture conditions in a culture medium containing a compound which prevents aging; and! maintaining the culture under conditions and for a time sufficient for expression of the protein; ! wherein the cell culture exhibits an improved cell culture characteristic that differs from a corresponding cell culture characteristic that would be observed under identical conditions in otherwise identical to the rest of the environment in which no connection preventing aging; ! wherein the improved cell culture characteristic is selected from the group consisting of: increased titer, increased cell specific productivity, increased cell viability, increased integrated viable cell density, decreased accumulation of high molecular weight aggregates, decreased accumulation of acidic molecules, and combinations thereof. ! 2. The method of claim 1, wherein the compound prevents aging, selected from the group consisting of carnosine, acetyl-carnosine, homo-carnosine, anserine, and β-alanine and combinations thereof. ! 3. The method of claim 1, wherein the compound prevents aging is carnosine. ! 4. A method according to any one of claims 1, 2 or 3, characterized in that a compound which prevents aging, is present in the culture medium at a concentration of about 5 mM to 100 mM. ! 5. A method according to any one of claims 1, 2 or 3, characterized in that it additionally introducing into the cell culture


Summary. Glucose‐6‐phosphate dehydrogenase (G6PD) deficiency was detected in 16 (69.6%) of a group of 23 neonates who had unexplained moderate or severe jaundice. This proportion is significantly more than the 9.4% observed or the 22.2% expected in Jamaican neonates who are not moderately or severely jaundiced (P<0.003), and significantly more than the 12.6% observed or the 21.0% expected in older Jamaican children and adults (P<0.003). Phenobarbitone therapy and phototherapy reduced the need for exchange transfusion but this was necessary in eight patients. Two babies developed kernicterus and one died. On the other hand, only two of 21 neonates who were identified as G6PD deficient at birth subsequently became moderately or severely jaundiced, and this could be attributed to other causes in both cases. These findings indicate that apparently spontaneous neonatal juandice is important in infants who have the G6PD A— enzyme. However, the jaundice is probably precipitated by unknown factors to which the G6PD deficient neonate is more susceptible than the infant who is not G6PD deficient. There is also a slightly increased incidence of G6PD deficiency in neonates who develop jaundice because of ABO or Rh(D) iso‐immune disease, infection or prematurity.


The paper mainly introduces the current situation,the main patterns,the benefit,the existing problems and the application prospect of the integration of water into fertilizer in sunlight greenhouse.


Summary Complex compounds of manganese with the amino acids glycine, cysteine and methionine were synthesized. The impact of these complexes on growth, development of seedlings and chlorophyll content was studied. Manganese complex with cysteine had a positive effect on seed germination of wheat. Seedlings treated with this complex contained more chlorophyll and were resistant to drought.


The effect of deep convection on the intensities of gravity waves and turbulence during the summer at White Sands, New Mexico, is investigated using 50-MHz mesosphere‐stratosphere‐troposphere (MST) radar observations and surface weather reports. Radar data taken at 3-min intervals from the summers of 1991 through 1996 (with occasional gaps of varying length) are used to construct hourly means, medians, and standard deviations of wind speed, spectral width ( ), and backscattered power calibrated as the refractivity turbulence 2 s turb structure constant ( ). The hourly variance of the vertical velocity is used as an indicator of high-frequency 2 2 C s n w gravity wave intensity. Surface observations taken near the radar site are used to identify periods marked by convection at or near the radar. During cases in which no convection is reported, the median hourly is nearly 2 s w constant with altitude (about 0.04 m 2 s 22 below and 0.03 m2 s 22 above the tropopause). Values of , , and 22 s C wn are significantly enhanced from no-convection cases to thunderstorm cases. Largest increases are about 12 2 s turb dB relative to the no-convection cases at about 11 km for , about 9.5 km for , and about 7.5 km for 22 ss w turb . The relatively lower height for the maximum of is likely due to the influence of humidity advected 2 2 CC n n upward during convection on the mean gradient of the refractive index. The probability density distributions of and near their levels of maximum enhancement are unimodal, with the modes steadily increasing with 22 C s n turb increasing proximity of convection. However, the probability density distribution of is bimodal in all instances, 2 s w suggesting that there can be enhanced wave activity even when visible convection is not present and that the presence of a thunderstorm at the station does not necessarily indicate greatly enhanced wave activity.


Objective To investigate the infection situation and high-risk subtypes distribution of human papilloma virus( HPV) in the cervices. Methods Twenty-one Human Papilloma virus( HPV) subtypes were analyzed by flow-through hybridization and gene chip( Hybri Max) for 1 585 cases. The thin-cytologic test( TCT) and pathological biopsy were carried out for high-risk HPV positive patients. Results Among the1 585 cases,414 cases were positive. The infection rate was 26. 12%. The high risk type composition rate was 82. 61%. The single high risk subtype composition rate was 83. 33%. As for the HPV subtype,52,16 and 38 were the main subtypes. The detected frequency of the main subtype was 26. 57%,25. 60%,and13. 29%,respectively. The infection rate of high risk subtype HPV was more and more higher with the age increasing. There were 38 cases of TCT positive and 33 cases of pathological biopsy positive among 342 cases of high-risk HPV positive patients. Conclusion The results showed that the cervices had a higher infection rate of high risk subtype HPV. HPV 52,16 and 38 were the main subtypes in cervices.


This paper discusses a test-question database of "Electrotechnics" developed on the Windows platform. By using Access '97, the authors help to overcome the defects of the other database systems which can not provide both graphics and text contents. The database, with the feature of open structure can swit the wide range content of electrotechnical course.


This study aimed to assess whether a lower initial dose of mirtazapine can lessen the harmful effect on driving performance or not in a double‐blinded, placebo‐controlled crossover trial.


The rich cultural and historical past of the Balkan nations is inspiring when one writes about the imperialistic strives of the Balkan states towards Macedonia and the Macedonians. The Balkan scientists' research contributed to the megalomaniac politics of the state of their origin. In such conditions, the two Balkan wars and the inexistence of Macedonians when it comes to the public were inevitable.


[1] A new sampling and analysis method for acquiring low-noise spectra using the Brewer spectrophotometer is applied to ground-based spectral measurements of global ultraviolet radiation. The new technique substantially reduces noise caused by changing atmospheric conditions that can occur during the sampling period. Routine measurements made at Toronto between 1996 and 2006 were used to develop a statistical model for determining total ozone and other variables from the global spectral data. Long-term comparison of global measurements with direct measurements demonstrates that global scan data can be used to measure total ozone with an accuracy better than ±1% for a wide variety of total ozone amounts and vertical profiles under clear skies. Other information such as ozone temperature and instrument wavelength stability can also be extracted. The measurements compared with model results show good agreement for clear-sky conditions. The results indicate that atmospheric aerosols and clouds can enhance absorption of UV radiation by ozone. For aerosol optical depth of one, the absorption enhancement is about 2.0% at air mass value of 1 and drops to 0.5% enhancement for air mass values between 2 and 3. For clouds the enhancement is generally small in winter months but can be substantial in summer months. The statistical relationship used for measuring total ozone using spectral global irradiance data is given. Comparisons of total ozone and ozone temperature derived from global scans with those from direct Sun scans are shown, and the effects of aerosols and clouds on derived total ozone from global data are discussed.


Pristina (Pristina) synclites (Pristinide) and rare Bratislavia palmeni (Naididae), collected from Hemşin Stream (Rize-Pazar; part of the lower Yeşilırmak River System) and Lake Çıldır respectively, are new records for the Turkish Oligochaeta fauna. In addition, the genus Bratislavia is also new for the Anatolian fauna.


religion. His intellectual progress from Koranic studies, through Sufism and medieval Persian-Arabic philosophy to Islamic modernism, particularly to Iqbal and Indian Islam, was accompanied by a spiritual progress from the Catholic church to Bahaism, almost tragically, as Franceso Gabrieli remarks in his Preface, since in Iran, the Muslim culture he chose for his own, it has recently enjoyed such total execration. He also made major contributions to the history of literature, particularly of Persian prosody, and the history of science and the pseudo-sciences. His last published article, in the Enciclopedia dell'Arte I (Rome, 1991), was " Alchimia Islam". These wide sympathies were further augmented by his constant travels, both in Europe and in Asia, even to Malaysia and Indonesia. Given Bausani's remarkable achievement the present two volumes could easily have been twice as long. The Editors in their Foreword explain that, for practical reasons, they decided to solicit contributions principally from his friends and pupils and to limit its scope principally to Islam, to Iran and to linguistics. Fortunately they were obliged to relax these stringent conditions, since, as they sharply remark, a number of contributors failed to deliver and thus excluded themselves. Like the enemies of Bausani (for strangely enough he appears to have had some) who were not asked to contribute, they are conspicuous by their absence. One perhaps paradoxical feature of a memorial volume is that it is meant to give a picture of its subject's interests, sympathies and achievements but through the contributions of others. It is not there to be read through from beginning to end, and in the case of Bausani that would be far beyond the scope of the average reviewer. In volume I, to mention merely a few of the contributions, the reader will learn interesting things on Burmese mosques; the use and interpretation of Koranic ayas in the Rasa'il Ikhwan al-Safa', a subject dear to Bausani's heart; Indo-Pakistani muftis and the dilemmas of modern morals; the symbolism of kilims; the Persian background to British concern with Sistan and Baluchistan in the aftermath of the First Afghan War; and Persian local histories. Among all these Fritz Meier's " Kundgebungen an und hinter der Front zwischen Muslimen und Christen" (pp. 305-25) is worthy of particular mention, since it brings to an obvious but neglected subject, the practice of religious jihad in the later Muslim Middle Ages, much curious detail; it is also one of the few articles in this large collection in which the history of the Maghrib plays a prominent part. In volume II there are important contributions on alchemy, talismans and a giant emerald carved for the Khwarazmshah 'Ala al-Dln Tekesh. The linguistic contributions include, among many other languages, Punic and Esperanto. And the literary historians, in one of the strongest sections, illuminate more than Bausani's own preferred field, Persian literature. As the editors say, Bausani evolved a new way to do philology: "conoscenza profonda comparativa delle lingue, accompagnata da una ancor piu profonda empatica considerazione storico-filosofica dell'entero processo culturale della civilta cui le lingue in questione afferiscono". Even if not all the contributors can claim to have advanced this to a method these two volumes are faithful to the memory of a much-loved scholar and teacher in reflecting his kaleidoscopic interests.


A short, semi-microscale synthesis of two 1,4-dihydropyridine drug analogues via a Hantzsch reaction is described, which is appropriate for a second-year undergraduate organic laboratory. Products are specifically chosen to highlight the biological relevance of this compound type while introducing the notion of a privileged structure. 1,4-Dihydropyridines are bioactive as calcium channel blockers and antioxidants and are lead candidates in the treatment of various medical conditions. Students generate one substituted 1,4-dihydropyridine by an operationally simple process and characterize it by melting point measurements, IR spectroscopy, and 1H and 13C NMR spectroscopy. This provides a springboard to discuss concepts of green chemistry, structure−activity relationships, conformational analysis, and related synthetic approaches.


"The beginning of prose 1936" is written in pencil in large and sweeping letters on a double sheet of art paper folded in the form of a cover. The next page carries an alternative phrase: "Beginning of a novel about Patrik." Inside are seventy-four sheets of yellowed paper. The text had been copied by typewriter and edited by the author. The manuscript was saved by Zinaida Nikolaevna Pasternak, who knew her husband's habit of destroying unused materials and unfinished works. Later attempts to continue such prose, along with drafts and fair copies of manuscripts, usually went to stoke the furnace at Peredelkino.


The reaction of isobutene with 1,12-dodecanedioic dichloride in the presence of aluminium chloride leads to a dimeric pyrylium salt (I), though by modifying the conditions of the reaction a mixture is obtained which, after amminolysis, gives mainly the monomeric [10]-(2,6)-pyridinophane (II).


The synthesis of 2-(2-carboxyethyl)-1-(3-carboxypropyl)-3,4-dihydro-6-methoxynaphthalene (28) and the homologous diacid (30) has been achieved in a single step from the 2-(6-carboxy-3-oxoalkyl)-3,4-dihydro-6-methoxynaphthalen-1(2H)-ones (22) and (24), respectively, via a novel acid-catalysed cyclisation–rearrangement reaction. The structure of the diacids (28) and (30) is supported by the high resolution mass spectrometric data of their respective dimethyl esters (29) and (31). The aromatic methoxy-group and the carboxy-function at C-6 in the side chain are critical for the rearrangement, but not for the cyclisation, part of the reaction. Based on this and other observations a mechanism for this novel rearrangement reaction has been proposed.


Simple Summary Hepatocellular carcinoma (HCC) is characterized by a broad molecular and genetic heterogeneity, which makes it a challenging subject in terms of the underlying mechanisms, response and resistance to treatment, and finding novel therapeutic options. Nowadays, new experimental models (3D in vitro models, in vivo mouse and non-mouse models, and computational studies) allow more detailed studies of hepatocellular carcinoma pathogenesis and treatment. Here, we provide insights into the current preclinical models frequently applied for the study of hepatocellular carcinoma. Abstract Hepatocellular carcinoma (HCC), the most frequent form of primary liver carcinoma, is a heterogenous and complex tumor type with increased incidence, poor prognosis, and high mortality. The actual therapeutic arsenal is narrow and poorly effective, rendering this disease a global health concern. Although considerable progress has been made in terms of understanding the pathogenesis, molecular mechanisms, genetics, and therapeutical approaches, several facets of human HCC remain undiscovered. A valuable and prompt approach to acquire further knowledge about the unrevealed aspects of HCC and novel therapeutic candidates is represented by the application of experimental models. Experimental models (in vivo and in vitro 2D and 3D models) are considered reliable tools to gather data for clinical usability. This review offers an overview of the currently available preclinical models frequently applied for the study of hepatocellular carcinoma in terms of initiation, development, and progression, as well as for the discovery of efficient treatments, highlighting the advantages and the limitations of each model. Furthermore, we also focus on the role played by computational studies (in silico models and artificial intelligence-based prediction models) as promising novel tools in liver cancer research.


This paper develops a motivation-based perspective to explore how organisations resolve the social dilemma of knowledge sharing, and the ways in which different motivational mechanisms interact to foster knowledge sharing and creation in different organisational contexts. The core assumption is that the willingness of organisational members to engage in knowledge sharing can be viewed on a continuum from purely opportunistic behaviour regulated by extrinsic incentives to an apparently altruistic stance fostered by social norms and group identity. The analysis builds on a three-category taxonomy of motivation: adding 'hedonic' motivation to the traditional dichotomy of extrinsic and intrinsic motivation. Based on an analysis of empirical case studies in the literature, we argue that the interaction and mix of the three different motivators play a key role in regulating and translating potential into actual behaviour, and they underline the complex dynamics of knowledge sharing and creation in different organisational contexts.


Interactive spatial arrangement and grouping (A&G) of images is a critical step of the sense-making process. We argue that to support A&G tasks, a visual encoding idiom should avoid clutter, show groups explicitly, and maximize the use of space while allowing free positioning. None of the existing interactive idioms supporting A&G tasks optimizes all these criteria at once. We propose and implement an interactive Voronoi treemap for A&G that fulfills all these requirements. The cells representing groups or objects can be dragged or clicked to arrange objects and groups and to create, merge, split, expand, or collapse groups. We present a usage scenario for an art quiz game and a comparative analysis of our approach to the recent Piling.js library for a categorization task of HiC data images. We discuss limitations and future work. CCS Concepts • Human-centered computing → Treemaps; Visualization design and evaluation methods;


In order to improve mixing quantity of VRO in Catatytic Cracking Unit to processdeeply residue oil and to gain economic benefit,We had taken a series of technical measures which include using metal passivant to reduce contamination,using coking inhibitor to refrain coking of oil slurry system ,and increasing steam quantity to reduce system coking.Mixing quantity of VRO was improved year by year through optimizing process parameters(data) of reaction and fractional system.In Oct.1996 VRO began to be mixed,until Oct.1999,mixing ratio of VRO had been improved up to 34.23%,which broke through the design capacity of the unit.


[GGM] prove that if there is a Pseudo-random number generator, then there is a pseudo-random function generator. We prove here that if there is a pseudo-random function generator, then there is a pseudo-random permutation generator. We also prove that if two permutation generators which are "slightly secure" are cryptographically composed, the result is more secure than either one alone. 1. I n t r o d u c t i o n 1 . I M o t i v a t i o n The field of cryptography has changed dramatically over the past few years. In the old age, cryptography was an art more than a science. Cryptosystem design was based on clever ad hoe ideas. The security of the cryptosystem rested solely on the cleverness of the designer; a cryptosystem was deemed secure until it was broken (in many cases the cryptographer only knew it was broken long after the breaker). Certain design rules, such as cryptographic composition, were recognized as playing a crucial role in improving security. Eventually, the apparent increase in security obtained by using these design rules became part of the folklore, although there were no formal proofs that security was increased. The foundations of cryptography were not yet established, there was no established formal framework for talking about a cryptographic protocol, security, etc. Thus, there was no formal way to either confirm or dispute the folklore. More recently, researchers have formalized the Permission to copy without fee all or part of this material is granted provided that the copies are not made or distributed for direct commercial advantage, the ACM copyright notice and the title of the publication and its date appear, and notice is given that copying is by permission of the Association for Computing Machinery. To copy otherwise, or to republish, requires a fee and/or specific permission. © 1986 A C M 0-89791-193-8/86/0500/0356 $00.75 notions of cryptographic protocols and security until today cryptography is an integral part of computational complexity. Many cryptosystems whose security is based on mathematical assumptions have come out of this research. However, the security of cryptosystems typically used in practice is still based on the old folklore. This paper is an attempt to use the new cryptographic rigor to formalize and analyze some of the previously unexamined folklore. One of the unexpected fruits of this work is that we show how to construct a pseudo-random permutation generator from a pseudo-random number generator. This result, besides the nice theoretical implications, has a very practical implication: One can generate a secure and relatively efficient block private key system from a pseudo-random number generator. One can also view this result as a partial justification of the design of the Data Encryption Standard (DES): we use some of the DES design features in the construction. As mentioned above, part of the cryptographic folklore is that cryptographic composition increases security. We formalize the notions of cryptographic composition and partial security in this paper. We then prove that indeed the folklore is correct, i.e. the cryptographic composition of two partially secure permutation generators yields a more secure permutation generator. 1.2 T h e D a t a E n c r y p t l o n S t a n d a r d The Data Encryption Standard (DES) is a private key cryptosystem developed by I.B.M. for the U.S. National Bureau of Standards, with an undisclosed amount of highly classified kibbitzing by the supersecret National Security Agency. The reader can consult [De] for more information about DES and [Ba] for more information about the National Security Agency and its rble in the development of DES. DES has features which make it very practical to use. However, one of the properties that DES does not have (as far as we know) is that it is provably secure


On the instructions of President and Government of the Russian Federation, works for development of National Atlas of Arctic are started in the country. In this article the authors present their ideas from viewpoint of geographers who are well experienced in the field of cartographic works. A structure of future Atlas and lines of approaches to its development are proposed. The totality of experiences of preparation of other geographical atlases in both, the USSR and Russia, as well as the latest achievements of cartography, aerospace sources and GIS - technologies are recommended to be used.  The National Atlas of Arctic is understood as a collection of knowledge of spatial - temporal information about geographical, ecological, economic, historical - ethnographic, cultural and social features of the Arctic. This cartographic model of the territory is designed for using in a wide range of scientific, managing, economic, defensive and social activities.  A hard copy of the atlas is intended to be used as scientific - reference publication while its electronic version will make it possible to renovate its content and to improve it by means of actualization according to various directions of its practical use  16 sections proposed in a draft of the Atlas content are as follows: introductory, geological structure, relief, mineral resources, environment evolution, climate, land waters, seas, seashores, snow cover, glaciers, permafrost, soils, flora and fauna, state of the environment and the Nature protection, population, economics, and prospects for future.  The popular - scientific edition of the Atlas is intended for use by wide circle of readers and also as a textbook for all levels of education. Presentation of material in the Atlas should combine a high scientific level and accessible language. In a popular form it will clarify traditions of careful treatment to the Nature and the nature - protective ethics of religious confessions of local people. Touristic maps will serve as guides for the Arctic with its bio - landscape and cultural diversity. Content of the Atlas should meet requirements of education standard in the field of geography. Ten sections are proposed for this version of the Atlas: introductory, geological structure, relief and resources, climate, permafrost and glaciers, land waters, seas of the Russian part of the Arctic, its flora and fauna, soils, population and economics, and conclusion  Scientific and social results of the Atlas publication together with editorial and advertizing effects are demonstrated. Proposals for a format, scales of maps and type of edition are given, and potential participants of this project are indicated.


By using some approximations it is possible to get fairly simple approximate formulas for the number of resonance frequencies and for the point impedance of thin cylinders. Measurements of the resonance frequencies and of the number of resonances within a certain frequency range confirm the theoretical results.


Pelvic implant failure of the pelvic floor to treat the support levator, and a method of surgically placing a pelvic implant is described. Pelvic implant (100, 102), the extension portion to provide a tissue support portion to be placed in contact with the tissue to be supported (104), additional support extends from the tissue support portion and (106, 110) may comprise a tissue fastener to attach the extension to the support tissue (108, 112).


We consider magnetic Schrödinger operators on quantum graphs with identical edges. The spectral problem for the quantum graph is reduced to the discrete magnetic Laplacian on the corresponding combinatorial graph and a certain Hill equation. This may be viewed as a generalization of the classical spectral analysis for the Hill operator to such structures. Using this correspondence we show that that the number of gaps in the spectrum of Schrödinger operators in graphs admits an estimate from below in terms of the Hill operator independently of the graph structure. We also discuss the decoration of graphs in the context of this correspondence.


This paper describes an analysis of the factors surrounding a post-fire flooding event that occurred in the Alpine Shire, Victoria, Australia in late February 2003. Flash flooding occurred because of highly localised thunderstorms and was enhanced by the burned landscape. In addition, our analysis of the resulting situation suggests that other contributing factors included the storm cells likely being pulse wet microburst, cell regeneration over the same area, and the steepness of the Buckland River Catchment. The synoptic conditions surrounding the event suggest that the major drivers of the extreme rainfall event were the high levels of precipitable water in the atmosphere and enhanced atmospheric instability (including associated high CAPE values) from increased surface heating due to the reduction in surface albedo and soil moisture of the recently burned fire surface. In addition, weak upper atmospheric winds during the flash flood event contributed to slow storm movement. Hydrological modelling of the flash flooding event further indicated that fire-induced soil hydrophobicity was likely to have caused an enhancement of the hydrological response of the catchment. With an increase in frequency of fires expected in the Alpine Shire associated with anthropogenic climate change, the relationship between fire and flood, even for rare events, has implications for emergency managers and Alpine Shire residents. It is intended that the results of this study will assist in emergency preparedness and thereby contribute to a reduction in the vulnerability of fire-affected communities to post-fire flash floods.


One of the many tasks of financial market research is to develop client-oriented financial products. In order to ensure that the financial products reflect the necessities and preferences of the clients, profound participation of the target group throughout the whole research process is important. The use of pictures reduces problems of understanding and makes communication more interesting since everybody is now an insider in the discussion and can thus contribute his or her opinion. The use of pictures in research enhances participation and the research findings will be more target-group oriented. The extent to which the expense associated with using pictures in research ? which is not to be underestimated ? justifies the gains in terms of the information and data collected is rarely assessed. This article is addressed to researchers who investigate in similar situations and will offer them a basis of experience that they can take advantage of. The authors assume that information about the usefulness of the different techniques applied might be most interesting for other researchers. They conclude that the use of pictures in financial market research revealed some interesting results, albeit sometimes at quite a high cost. Nevertheless, the impact of supportive pictures on the quality of new knowledge is difficult to assess, since we have no way of answering the question of whether it would have been possible to obtain the same information without the suppor of pictures.


The article is devoted to the formation of career guidance competence issue of future geography teachers in professional education conditions. The structure of career guidance competence of the future experts is revealed. Based on the structure component analysis of the investigated competence are highlighted the motivational-value, cognitive, operational-active, emotional-volitional and evaluation-reflexive criteria. The indicators of career guidance competence development level of the studied professional category of specialists are revealed. It was established that the motivational- value criterion points to the level of motivation formation for professional and career guidance activities. The cognitive criterion characterizes the level of future geography teacher's assimilation with psychological and pedagogical, special and methodological career guidance knowledge which is necessary for the effective realization of main career guidance activities aspects. Operational-active criterion demonstrates the ability to solve typical and non-standard situations in career guidance activity through the personal and professional interpretation of professional knowledge (psychological and pedagogical, special and methodological career guidance). It demonstrates the implementation of professional functions (prognostic, diagnostic, organizational, communicative and reflexive) in the process of career guidance work. Emotional-volitional criterion is characterized by the professional-personal qualities formation that influences to the professional activity result and determines the teacher's individual style. The essence of the evaluative-reflexive criterion is demonstrated in the personal ability to control the results of personal activities and achievements.The levels of professional competence development are defined. They are high, medium, low and initial. Initial level is characterized by the lack of career guidance skills, intuitive implementation of career guidance in the profile education. Pedagogical facts, phenomena, situations are perceived at the emotional level. We believe that low level is characterized by low motivation to professional activity and the lack of individual professional oriented skills (organization, planning, control). It is also characterized by template for the implementation of typical tasks. The medium level is characterized by ability of future geography teachers to demonstrate the sufficient gnostic, design, constructive, communicative and organizational skills and special skills for organizing the career guidance work in professional education. The reflection of personal career guidance work in the profile education conditions is developed. The high level is characterized by the demonstration of perfectly developed gnostic, design, constructive, communicative, androgenic and organizational skills and the skills for organizing career guidance work in professional education.


Perception and Interest in English Teaching as Profession
(A Survey towards Fifth Semester Students of English Department in
Muhammadiyah University of Purwokerto)
DENA YUDIAPASA MULYONO
1201050105
The aims of this research were 1) to describe the fifth semester students"
perception toward English teaching as a profession 2) to reveal the fifth semester
students" interest in English teaching as a profession. The research was
descriptive. It was survey study. The population of this research was the fifth
semester students of English Department of Muhammadiyah University of
Purwokerto. The researcher took 60 students as sample. The instruments of
collecting data were questionnaire and interview. Data collection was conducted
on December 2016. Based on the research result, researcher concluded that on
average the students" perception achieved M=2.95 (73.75%) and interest achieved
M=2.98 (74.5%). It means that generally the most of fifth semester students had
good perception and interest in English teaching as a profession.


In this work, we show that regular black holes in a Randall-Sundrum-type brane world model are generated by the nonlocal bulk influence, expressed by a constant parameter in the brane metric, only in the spherical case. In the axial case (black holes with rotation), this influence forbids them. A nonconstant bulk influence is necessary to generate regular black holes with rotation in this context.


(1) Background: The consumption of traditional foods has been linked to economic, social, and environmental sustainability; therefore, the main challenge of a changing marketplace is to ensure that young generations continue consuming traditional products. The current study uses a consumer culture theory (CCT) perspective to examine the following: (1) the way individuals use their traditional products to identify themselves with the culture and to feel that they are a part of the community, (2) the underlying values that turn young consumers into loyal customers of hellim/halloumi cheese, and (3) its implications to hellim/halloumi producers. (2) Methods: A qualitative research method is applied to study the perceptions of post-millennials towards traditional cheese products from a cultural perspective. (3) Results: The results of the study reveal that loyalty towards traditional food products amongst post-millennials is build based on (1) the memories that surround the food, (2) the rituals that preparing and eating a food involve, and (3) the identity that it builds, allowing people feel sense of belonging to their ethnic group. (4) Conclusions: Loyalty amongst post-millennials towards traditional food products tends to be emotional, rather than rational or behavioral. It allows us to present both theoretical and managerial implications. It also calls for more empirical research to understand the changing marketplace and post-millennials' consumption habits.


Psychologically healthy is a very important issue that the government cares about,school concerns,parents are anxious about.Now most of the university students are born after 1990,due to their lives,family environment,social environment,and different educational environment,there is a big difference between now and the past.Our educators must pay more attention to and reflection on that.


To develop food additives from pyroligneous liquor, we first examined the physicochemical characteristics of volatile substances. The pH, gravity, acidity, solution tar, and scorched remains in the pyroligneous liquor were 2.50, 1.020, and respectively. The main compounds of pyroligneous liquor were 2,6-dimethoxyphenol (syringol), 2-hydroxy-2-cyclopenten-l-one, 1,2-benzenediol (catechol), phenol, 2 (5H)-furanone, 2-methoxyphenol (guaiacol), 5-hydroxymethyl-2 furancarboxaldehyde were found in organic phase, whereas catechol, 1,4 : 3,6-dianhydro--glucopyranose, cyclopropyl carbinol, 5-hydroxymethyl-2 furancarboxaldehyde in aqueous phase.


When a tunnel is constructed by blasting,the stability of surrounding rock near tunnel face is important for safety of builders and tunnel itself. It is testified that the blasting vibration rule obtained from area remote blasting source is not suitable for the area near tunnel blasting source. So it is necessary to test blasting vibration of the surrounding rock near tunnel blasting source and to study the blasting vibration rule. Based on Qipanshan tunnel of Guiyang-Guangzhou railway,the tailor-made blasting vibration sensors are disposed in the arch crown surrounding rock within the range of 5 m to test the blasting vibration velocity. Taking advantage of middle drift excavation,the tailor-made blasting vibration sensors are disposed in upper and side surrounding rocks within the range of 2 m to test blasting vibration velocity. The blasting vibration rules of arch crown and upper and side surrounding rocks behind tunnel face are studied. The study results can provide references for tunnel blasting construction.


We extend existing work on the propagation of ultra-high energy cosmic rays in extragalactic magnetic fields to a possible component of heavy nuclei, taking into account photodisintegration, pion production, and creation of e+e- pairs. We focus on the influence of the magnetic field on the spectrum and chemical composition of observed ultra-high energy cosmic rays. We apply our simulations to the scenarios proposed by Anchordoqui et al, in which Iron nuclei are accelerated in nearby starburst galaxies, and show that it is in marginal agreement with the data. We also show that it is highly unlikely to detect He nuclei from M87 at the highest energies observed $\sim3 10^{20} $eV as required for the scenario of Ahn et al. in which the highest energy cosmic rays originate from M87 and are deflected in a Parker spiral Galactic magnetic field.


We designed and characterized an SWG waveguide directional coupler-based 1310/1550 nm diplexer. The fabricated diplexer has an extinction ratio of 23/14 dB at 1310/1550 nm. We observe a blue-shift between simulation and characterization.


T his study examined the signicant effect of E-learning and its role in instruction of students of Umaru Musa Yar'adua University Katsina. The objective of the study was to determine the strength of the relationship between-learning and motivation among students participating in the research. The study used descriptive research design of survey type. The population of the study covered a total number of Four Hundred and Eighty-Eight (488) 200 level Education students out of which217 students were sampled using simple random sampling technique. Two validated instruments were used namely (E-learning questionnaire and Intrinsic Motivation questionnaire) The instrument was applied to collect information from students of Umaru Musa Yar'adua University Katsina, the result of the ndings shows that e-learning is an element which affects students' motivation. The statistical method of Pearson's correlation coefcient was used for data analysis.


into individual practices was carried out for the full year of the study. Group B (control group) will be educated in the second year. The range of outcome variables being assessed include general practitioner's identification index. patient's outcome for depression, prescription of antidepressants, referrals to secondary care, suicide rates, and the cost effectiveness of the intervention. Methodological and practical issues will be presented.


Background: In 1966, the Gaffrée and Guinle University Hospital – GGUH was incorporated into the Federal University of the State of Rio de Janeiro – UNIRIO. Since then the Homeopathy clinic has had it's service there. Since the creation of medical residency in Homeopathy in 2004, there has been a significant increase of treatment in the number of patients and also a significant increase in the inter-relationship with other specialists and hospital services. A wide variety of patients have been treated at the GGUH on a daily basis. Many patients have been examined and treated with homeopathy alone, while others were also examined in other specialties, making homeopathic treatment an adjunct to classical therapy and vice versa. Given the expressive number of medical consultations (around 2500/year), this outstanding result in our clinical and academic practice has created the relevance and need for the verification of the epidemiological profile of these patients. Epidemiological studies are needed to clearly show the population included in this hospital, which is considered to be a reference in the Brazilian Health System (SUS).

Aims: To demonstrate the epidemiological and clinical homeopathic profile in the ambulatory of homeopathy at the Gaffrée and Guinle University Hospital (GGUH) of the Federal University of the Staate of Rio de Janeiro - UNIRIO, Brazil.

Methodology: Cross-sectional study of 140 medical records randomly selected from the ambulatory of homeopathy at GGUH. The sample represents 50% of the monthly average of the clinical service from January to October 2009. The medical records incorrectly completed for the data analysis were excluded. Microsoft Office Excel 2007 used to data collection and analysis.

Results and Discussion: A total of 100 records were selected for analysis (71.4%). Average age: 50 years old, 69% being between 41 and 80 years old. Gender: 79% women and 21% men. Marital status: 46% married, 36% single, 10% divorced and 8% widowed. Color: 61% white, 31% colored and 8% black. Education: Only 12% obtained an undergratuadion degree. Groups of diseases: Group-01 (48%) high prevalence: 19% respiratory, 15% osteoarticular and 14% psychiatric; Group-02 (45%) medium prevalence: 11% gastrointestinal, 9% cardiovascular, 8% genitourinary, 6% neurological, 6% dermatologic and 5% endocrine; Group-03 (7%) low prevalence: 3% otological, 2% immunological, 1% oncological and 1% ophtalmological. 82% of the patients were treated solely with homeopathy and 18% with homeopathy and allopathy. Clinical-homeopathic diagnosis: 53% functional, 38% lesional; 9% sensorial. Constitutional diagnoses: 31% sulfuric, 25% phosphoric, 22% carbonic, 22% mixed. Miasmatic / diathesic diagnosis: 47% sycotic, 28% psoric, 12.5% mixed, 9.5% tuberculinic, 3% syphilinic.

Conclusion: This study demonstrated a higher prevalence of women over 50 years old with respiratory, osteoarticular and psychiatric diseases. Most of them had a sulfuric constitution and presented functional diseases of sycotic origin. Homeopathy was the most adopted treatment during the period studied. This knowledge led to the creation of the "Homeopathic Clinical Identification Summary" which is used in the GGUH ambulatory. Epidemiological and clinical data were extracted from this summary with the objective to construct clinical trials.


Carbon dioxide fixation in its intact form is achieved from ''bifunctional'' complexes containing in their structure a nucleophilic cobalt(I) and an alkali cation: Co(R-salen)M (R-salen = substituted salen ligand; salen = N,N'-ethylenebis(salicylideneaminato); M = Li, Na, K, Cs). The fixation of CO/sub 2/ by such systems displays different degrees of reversibility depending on the reaction solvent and the nature of the alkali cation. The X-ray analysis carried out on (Co(n-Pr-salen)K-(CO)/sub 2/(THF)) shows carbon dioxide anchored to the cobalt through a Co-C sigma bond, while the oxygens interact with the alkali cation, in a polymeric structure. IR spectra are diagnostic for the presence of CO/sub 2/ bonded as a bent molecule in a reduced form displaying three strong bands in the following ranges: 1700-1650, 1300-1250, and 1250-1200 cm/sup -1/. The binding of CO/sub 2/ is partially prevented in the presence of a crown ether, which can complex the alkali cation. The reaction of (Co(salen)Na(CO/sub 2/)) and (Co(salen)Na(THF)) with dicyclohexano-18 crown-6(DCHC) gave a complex, (Co(salen)Na)/sub 2/(DCHC), whose structure shows the presence of the intact bifunctional unit where, however, all the coordination sites around the alkali cation are filled by the oxygens from salen and DCHC and are not further available for bindingmore » the oxygen atoms of the CO/sub 2/ molecule. Crystallographic details and the final R factor for specific observed reflections are given for (Co(n-Pr-salen)K(CO/sub 2/)(THF))/sub n/, (CO(n-Pr-salen)K(CO/sub 2/)(THF))/sub n/, (Co(salen)Na)/sub 2/(DCHC).« less


Amyotrophic lateral sclerosis, the most common form of motor neuron disease (MND), is a relentless and fatal neurodegenerative disorder causing degeneration of both upper and lower motor neurons with subsequent loss of motor functions. Although the association of cognitive and behavioural symptoms in ALS has been clearly documented in the literature for more than 100 years, only recently has the ALS research community adopted the concept that ALS is a multi-system disorder associated not only with MND, but also with frontal and temporal lobar dysfunction [1]. This may manifest along a continuum as ALS with frontotemporal dementia (ALS-FTD) [2], ALS with cognitive impairment (ALSci), and ALS with behavioural impairment (ALSbi) according to proposed consensus diagnostic criteria [3]. In this issue of the European Journal of Neurology, Witgert & Salamone et al. [4] characterize frontally mediated behavioural symptoms in 225 sporadic ALS patients using the Frontal Systems Behavioural Scale (FrSBe) which assesses apathy, executive dysfunction and disinhibition [5]. This cross-sectional study demonstrated that frontal behavioural dysfunction is common, occurring in approximately 1⁄4 of their cohort with no differences in severity between bulbarand limb-onset ALS cases. The most common behavioural disturbance was apathy evident in about 30%. Previous studies support the current finding that apathy is common in ALS [6–8], but it is typically seen more frequently in bulbar-onset ALS [6,8]. Other frontal behaviours such as increase in self-centredness, indifference, perseveration, irritability, emotional blunting or lability, inflexibility and restlessness have been documented [6,7]. Less common were temporal lobe features such as obsessions and repetitive, stereotyped behaviours [7]. Cognitive impairment is relatively common in ALS with one study showing up to 51% of patients having symptoms ranging from mild to severe [9]. A recent meta-analysis has demonstrated that neuropsychological tests assessing domains of verbal fluency, psychomotor speed, language, visual memory, immediate verbal memory and executive functions were most sensitive in detecting cognitive impairments in ALS [10]. Importantly, Witgert & Salamone et al. [4] also investigated the relationship between cognitive impairment and frontal behaviours by stratifying a large subset of their cohort using a detailed neuropsychological battery into cognitively intact, mild cognitive impairment and moderate to severe cognitive impairment groups. They found that 16% of the cognitively intact group had behavioural dysfunction, and those with evidence of cognitive impairment were more probably to have frontal behavioural disturbance, in particular apathy. However, 2/3 of the moderate to severe cognitively impaired group had no behavioural dysfunction. Hence, concordance in ALS patients having cognitive and behavioural abnormalities was not complete demonstrating the limitation of employing the consensus criteria to stratify patients into ALSci and ALSbi categories [3]. Strengths of this study include behavioural assessment in a large sample of ALS patients – the largest to our knowledge, detailed neuropsychological assessment, and use of a validated and reliable measure of frontal dysfunction, the FrSBe. There are some important limitations with the study, the first being that the FrSBe was not designed to assess frontal dysfunction in patients with significant physical and functional disabilities; several questions pertaining to apathy are confounded by the severe motor impairment and functional limitation in patients with ALS. In addition, other important behavioural symptoms mediated by non-frontal areas of the brain such as anxiety, compulsions and psychosis are not assessed by the FrSBe. Tools such as the Neuropsychiatric Inventory [11], the Frontal Behavioural Inventory [12] and the Manchester FTD Behaviour Interview [7] covering a broader range of behaviours might address this issue. Witgert & Salamone et al. [4] did not present any structural or functional neuroimaging in their study. Atrophy and/or hypoperfusion/metabolism on structural and functional neuroimaging, respectively, in mesial prefrontal and anterior temporal structures as well as the anterior cingulate gyrus have been demonstrated in ALS patients with and without cognitive impairment [13]. Generally, these changes are more pronounced in frontotemporal regions in ALSci. To our knowledge, there have been no studies to date which have correlated behavioural symptoms directly with neuroimaging measures in ALS. Of relevance, MRI studies have demonstrated that atrophy in the dorsolateral prefrontal cortex and anterior cingulate gyrus was associated with apathy in FTD [14]. Similarly, in Alzheimer s disease, apathy was associated with reduced blood flow on SPECT in the anterior cingulate gyrus and orbitofrontal regions [15]. Therefore, limbicprefrontal circuits are important in apathy across different dementias and it will be imperative to determine their role in apathy associated with ALS.


A new moving mobile device for grinding-head of guideway grinder is designed.In the paper,the design requirements and working principle are explained.Especially,the design features of the device are introduced in detail.Finally,the performance characteristics of the device are obtained.


The peculiar blood group "system" that includes what may be called the "Donna" antigen and the corresponding "anti‐Donna" antibody (for lack of a more specific name) has defied detailed analysis for several years.


Fiber-optic Bragg gratings are frequently utilized for a variety of strain and temperature
sensing applications. The wavelength encoded information allows for practical
multiplexing schemes that have already found there way into advanced smart structure
systems. When strain gradients along the length of the grating exist, the reflection
spectrum can broaden and develop multiple reflection peaks[1-3]. A similar reflection
spectrum can develop due to unequal diametric strain.


Marketing Mix is one of the main concepts in modern marketing, which has an important role in influencing customers to buy products and services offered by the market, therefore the marketing mix is said to be a tool that will show the level of marketing success. To find out whether there is an effect of product, price, place, and promotion on the satisfaction of users of the J&T Express Saentis Delivery Service Medan branch. This type of research uses quantitative research methods with primary and secondary data sources. The number of samples in this study was 100 respondents who were determined using the Wibisono formula and purposive sampling technique, namely the technique of determining the sample based on certain considerations. This study uses SPSS 20.0 as a data processing tool. The results of this study indicate that the product has a positive and significant effect on J&T Express customer satisfaction, Price has a positive and significant effect on J&T Express customer satisfaction Place has a positive and significant effect on JN&Express customer satisfaction, and Promotion has a positive and significant effect on customer satisfaction. J&T Express customers. Meanwhile, Product, Price, Place, and Promotion simultaneously have a positive and significant effect on J&T Express customer satisfaction.


A dielectric analysis of fluorinated water-in-oil microemulsions was performed in the monophasic region of the phase diagram. Trends typical of percolation phenomena were found as well as trends of non percolating systems. At water to surfactant molar ratio 11, the microemulsions show a percolative behaviour described by scaling laws with exponents mainly typical of dynamic percolation. This implies that the droplets, which have in the dilute regime a hydrodynamic radius of 30 /spl Aring/ and interact via an attractive potential as shown by dynamic light scattering, maintain the structure of dispersed droplets upon an increase of the concentration of temperature.


Fig. 2. a) Positive correlation between gray matter concentration and connectivity to the left thalamus in the left precuneus/posterior cingulate cluster (MNI coordinate: -38,-2,2). b) Negative correlation between gray matter concentration and connectivity to the left thalamus in the left insula/putamen (MNI coordinate: -18,-60,4). Relationship between gray matter concentration and resting functional connectivity to the thalamus: Evidence of the temporal lobe epilepsy seizure network Martha J Holmes, Zhaohua Ding, Xue Yang, Bennett A Landman, John C Gore, Bassel Abou-Khalil, Hasan H Sonmezturk, and Victoria L Morgan Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN, United States, Institute of Imaging Science, Vanderbilt University, Nashville, TN, United States, Electrical Engineering, Vanderbilt University, Nashville, TN, United States, Neurology, Vanderbilt University, Nashville, TN, United States


Multi-stage and multi-load wireless power transfer (MMWPT) system is capable of providing multiple isolated power supplies, which is promising to be utilized to supply driver circuits of high-voltage power converters. This paper analyzes the impact of the parasitic resistors in compensation inductors on an MMWPT system, mainly about the impact on the characteristic of load currents and the system efficiency. A 6-stage and 6-load WPT system employing GaN-based high-frequency inverter is built to verify the analytical results, working at 200kHz.


Purpose
This study explores insights from key stakeholders into the skills they believe will be necessary for the future of work as we become more reliant on artificial intelligence (AI) and technology. The study also seeks to understand what human resource policies and educational interventions are needed to support and take advantage of these changes.

Design/methodology/approach
This is a qualitative study where a sample of highly experienced representatives from a range of small to large Irish organisations, both public and private, provide insights into this important topic.

Findings
Findings indicate participants see a continued need for soft and hard skills as we evolve towards a more technologised workplace, with a need for employees to adopt a lifelong learning philosophy. As the knowledge economy in Ireland is well established, experts do not expect mass displacement to occur but differ with respect to the predicted rate of change. Novel HR interventions such as hiring for potential, pooling talent and establishing postgraduate supply contracts are seen as key. Current state interventions were mostly viewed positively but revamping of curricula is needed as well as stronger partnerships with tertiary institutions.

Research limitations/implications
The interpretivist nature of the study limits the generalisability of the findings as they are based on a relatively small sample from one country. Also despite the significant expertise of the sample, it is not possible to predict whether their forecasts will manifest.

Practical implications
This research highlights the need for Irish SMEs to embrace the impacts of automation and AI as many are seen to be slow in reacting to changes in technology. The study also reveals cutting edge talent management interventions for employers to adopt that will insulate them from the challenges technological change presents to recruitment and employee development.

Originality/value
The findings from this paper culminate in the development of a conceptual framework, which encapsulates the responsibilities of all parties so that future skills needs will be met. This highlights the interplay between employers, individuals/employees, the Irish Government and educational institutions, demonstrating how they are interdependent on one another as we move towards a more technologised future.


Gulf of Suez 16 January to Geoffrey Dawson: [The Times' articles on the Hoare crisis] … evidently gave faithful expression to public feeling, and I congratulate you on the freshness and vigour with which they are written (I judge them to have been by your own hand). I'll have no difficulty in agreeing to this line of policy; though actually the Hoare-Laval plan doesn't appear to me to have been a reversal of policy so much as a panic amplification of the Eden offer made before hostilities began, and to have been quite unjustified by the present military position. The original Eden proposal of nearly a year ago (which as you remember we approved) still seems to me to have been perfectly sound and to stand as the proper bases of an agreed peace. […]


Project crashing, a.k.a. project compressing or time-cost trade-off, is an important aspect of managing construction projects. Project crashing can be defined as the time-cost optimization technique, which aims to compress the total project duration with the least incremental cost. In real life problems, the quality is affected when some activities are crashed. This effect may be in a positive or negative way. In addition, there may be strict contract clauses regarding the project duration in terms of early finish bonus and penalty. In this study, a mathematical integer linear programming optimization model is developed using Visual Basic Programming Language integrated with Excel Solver add-in, in order to evaluate different strategies for project execution considering time, cost and quality concerns. Moreover, the developed model takes into account the relationship between crashing cost, early finish bonus, and penalty cost. The proposed model enables project managers to select the most appropriate project crashing strategy at the beginning of the project. An illustrative example is also presented in order to show how the proposed approach can be implemented in real cases. © 2020 The Authors. Published by Budapest University of Technology and Economics & Diamond Congress Ltd Peer-review under responsibility of the Scientific Committee of the Creative Construction Conference 2020.


To address the varied requirements of portable video applications, new processor units are required that can execute a variety of intraframe coding algorithms in real-time. Furthermore, low complexity is required, as the intraframe coder is only one element of the complete video compression system. Neither programmable video signal processors (VSPs) nor dedicated ASICs can satisfy all of the above needs. The video compression processor unit (VCPU) described in this paper is based on a configurable architecture. An efficiency comparison is presented between this processor unit, a programmable VSP E33 and three dedicated video ASICs.<<ETX>>


We report a sun tracker sensor for attitude control of space navigation systems. The sensor exploits the concept of asynchronous operation previously devised by the authors for those devices. Asynchronous luminance sensors optimize sun trackers operation because only illuminated
 pixels are readout and can transmit data. This approach outperforms classic frame-based sun trackers in terms of bandwidth consumption, latency, and power consumption. The new sensor under study has been optimized for operation and interaction with other attitude control systems when it is
 embarked. The sensor power consumption is quite reduced. To save power, its pixels enter automatically in standby mode after gauging illumination levels. The device operates with only 0.45V. The pixel matrix has been devised to optionally be directly powered by energy harvesting systems based
 on photovoltaic diodes connected to a storage capacitor without a DC-DC converter.


The screening of Martin Bashir's Living with Michael Jackson on Australian television elicited a phenomenal amount of interest in the news media, at water coolers and on the Internet. Much of the response in the Australian print media was critical of Bashir's representation of Jackson, as well as denouncing Jackson as sad victim, warped predator and allround freakshow. This article considers these interpretations to argue that the production and consumption of 'wacko Jacko' is underpinned by the increasing instability of the natural in an age of information technologies, as well as the collapse of boundaries between documentary and fictional entertainment forms.


BACKGROUND: Carbon nanotubes (CNTs) are fast becoming key components in the production of high-strength composite materials. Two methods to prepare nanocomposites by covalent bonding between an epoxy matrix and functionalised CNTs that acted as cross-linkers during polymerisation were investigated.

RESULTS: In the standard method, 1 wt% functionalised CNTs was dispersed in epoxy, hardener was added and the composite was cured. In the masterbatch approach, 1 wt% functionalised CNTs was mixed with epoxy in the presence of triethylamine accelerator, then cured. This yielded partially cured epoxy; additional hardener was required to achieve complete curing. Improvements were observed in storage modulus (E′), flexural modulus (EB), wear resistance and hardness. Thermal stability did not change appreciably for samples prepared by either the standard or masterbatch methods. Variations in the results obtained as a function of preparation method, functionalised CNTs and hardener used are discussed.

CONCLUSION: Epoxy nanocomposites having improved mechanical properties were obtained by incorporating functionalised CNTs. Better interaction between the epoxy and CNT was achieved using the masterbatch method; this was attributed to covalent bonding between the CNTs and epoxy. However, optimisation of the CNTs, accelerator and hardener used in composite preparation is required to obtain improved physical properties. Copyright © 2009 Society of Chemical Industry


The contribution of nonlinearities in the basilar‐membrane response to the understanding of speech in noise was estimated by measuring growth of simultaneous masking for tones and speech. Speech signals were bandpass‐filtered nonsense syllables; consonant recognition and pure‐tone thresholds were measured as a function of masker level in two conditions: (1) masker within the passband of the speech and (2) masker below the passband of the speech. With this low‐frequency masker, the effect of the masker at the ''signal'' place is assumed to grow linearly whereas the growth of response to the speech at the ''signal'' place is compressed. Growth‐of‐masking functions were also measured for short‐duration tones in narrowband maskers centered at or below the signal frequency. Subjects were younger and older adults with normal hearing; these older adults were included given that age‐related changes in nonlinearities may occur even with minimal threshold elevation. For both subject groups, large individual differe...


The system of electronic medical records (EMR) has been widely adopted in physician practice. Physicians often get limited time to provide care services to patients. Improving practice efficiency is a promising direction to mitigate this predicament. During the encounter, ordering lab test is one of the most frequent actions in EMR system, mainly for diagnosis, screening related reasons or examination. In this paper, our motivation is to save physician's time by providing lab test ordering list to facilitate physician practice. We developed a novel weight based multi-label classification framework to learn to order lab test for the current encounter according to the historical EMR. We propose to learn the physician-specific lab test ordering pattern as different physicians may have different practice behaviour to the same population. Experimental results on the real data set demonstrate that physician-specific models can consistently outperform the baseline.


Economic sanctions often fail to achieve their stated ends, and at times can even be counterproductive. The mechanisms that lead to these negative outcomes remain unclear in the literature on economic sanctions however. One prominent theory holds that sanctions lead to a rally-around-the-flag effect, which generates greater support for the targeted regime or policy than would otherwise arise, but testing this view at the individual level has not generally been possible due to data availability. This study takes advantage of an individual-level panel survey in Ukraine that covers the period during which a political dispute in 2005-2006 between Ukraine and the Russian Federation led to a cut in gas exports to Ukraine, and subsequently, dramatically increasing gas prices. The findings show that individuals directly affected by the gas supply issues were significantly more likely to change their views in a "pro-Western" direction following the dispute, and to support more liberal economic policies than individuals who were not directly affected. This effect was more pronounced for Ukrainian than Russian language speakers, suggesting that dimensions of both identity and economic harm can channel the impact of sanction policies on public opinion following the use of economic sanctions.


Resting/dormant benzyl- and allyl-type Ti(IV) complexes formed under α-olefin polymerization conditions have been detected and characterized by NMR. Experimental and computational evidence supports a formation mechanism via reversible Ti–C bond homolysis rather than "classical" σ-bond metathesis.


Thyroid dysfunctions must be suspected in patients with mood episodes. Thyrotoxicosis may manifest as manic episodes with mixed features, with a severe presentation, including suicidality. Patients with affective disorders should be screened for thyroidopathy. A strategy combining thionamides, betablockers and psychotropics may lead to an efficient stabilization of mood symptoms.


The objective of the present study was to develop and validate a novel RP-HPLC method for the determination of Dasatinib in the pharmaceutical dosage form. Chromatographic separation was conducted on agilent technologies-1260 series with the G1311C quaternary pump, Thermo Scientific C18 column (4.6 mm i.d. × 250 mm, 5 μm particle size) and equipped with photodiode array detector G1315D. The mobile phase consisted of methanol and acetonitrile mixed in the ratio of 50:50 v/v, was used at a flow rate of 1 ml/min, and the detection wavelength was set at 323 nm. The retention time for Dasatinib was found to be 4.073 min. The calibration was linear (r 2 = 0.999) in the concentration range of 2-10 μg/ml. The limit of detection and the limit of quantitation were found to be 0.5263 μg/ml and 1.5948 μg/ml, respectively. Recovery of Dasatinib in tablet formulation was observed in the range of 98.0999.57%. Percentage assay of Dasatinib (Dasanat) was found to be 99.45% w/w. Thus the novel proposed method for Dasatinib was found to be feasible for the estimation of Dasatinib in bulk as well as the pharmaceutical dosage form. INTRODUCTION: The chemical name of Dasatinib is N-[2-Chloro-6-methylphenyl] -2[[6[4-(2-hydroxyethyl) -1piperazinyl] -2-methyl-4pyrimidinyl] amino] -5-thiazole carboxamide Fig 1. Dasatinib is utilized for the treatment of chronic myeloid leukemia and acute lymphoblastic leukemia. A thorough literature survey of Dasatinib revealed that very few analytical methods had been reported for estimation of Dasatinib hitherto. Majority of methods for determination of Dasatinib in biological fluids and pharmaceutical dosage forms includes LC-MS/MS 1-4 , LC-MS 5-6 , HPTLCLC 7 , HPTLC 8 , UPLC-MS 9 , HPLC-MS 10 , RPHPLC 11 and UV-Visible Spectrophotometric method 12-13 . QUICK RESPONSE CODE DOI: 10.13040/IJPSR.0975-8232.10(10).4531-37 The article can be accessed online on www.ijpsr.com DOI link: http://dx.doi.org/10.13040/IJPSR.0975-8232.10(10).4531-37 This novel proposed method contributes quick estimation, correct peak shape, precise, simple, and quick, use of smaller sample volumes and utilizing methanol as a mobile phase which is economical when compared with other existing methods. So, it is necessary to develop a simple, precise, and rapid RP-HPLC method for the quantitative determination of Dasatinib. This work describes the validation parameters stated by the International Conference on Harmonization [ICH] guidelines Q2 (R1) 14-18 . The chemical structure of dasatinib is shown in Fig. 1. FIG. 1: CHEMICAL STRUCTURE OF DASATINIB


Continuity and change is among the many important perspectives that may help understand the history of PRC's journalism.To well catch on the mainstream of PRC's journalism,we should not only put it back into Chinese long historical backgrounds,but also refer to the experience of other countries all around the world.Through such a dual sketch as traditional and modern,domestic and abroad,we could better examine the role and character of journalism in contemporary China.


To study the gas mixing capacity of circulating fluidised bed (CFB) biomass gasifiers, radial and axial gas concentration profiles have been measured and interpreted in a hot pilot scale biomass gasifier (100 kg/hr fuel). The presented data of the pilot scale gasifier are unique and provide new insight in the radial gas mixing capacity of circulating fluidised bed gasifiers. Considerable radial gas phase concentration gradients have been observed in the pilot plant gasifier, with a difference between wall and centre concentrations up to a factor 3. It must be concluded that the radial gas mixing is far from ideal. On basis of these pilot plant data and the standard dispersion model (to describe gas mixing) it can be concluded that the radial Peclet number of the dilute region is in the order of 1000. Such a value excludes the radial mixing of gases almost entirely.


With the development of the Semantic Web, the research of knowledge acquisition technology and ontology are becoming hotly. The study of domain ontology for Chinese description is also increasingly concerned. After introducing the relevant definition of ontology and the theory of knowledge acquisition, the paper discusses the knowledge acquisition technology based on ontology. Finally, a domain ontology semi-automatic construction model towards Chinese text is proposed and applied in maritime field, which improves the automation and speed of ontology construction through the cycle of improvement and updating to the initial seed ontology, and also provides the basis protection for the in-depth study of domain ontology.


Ferroresonance is a common and complex phenomenon in power systems. Some types of ferroresonances are remarkably difficult to distinguish from others. This study adopts non-linear analysis methods to directly extract non-linear characteristic quantities from ferroresonance overvoltage time series (FOTS). Simulated and practical FOTS are investigated to validate the proposed method. Non-linear characteristic quantities, i.e. average grey value of reconstructed attractor and improved largest Lyapunov exponent of ferroresonance overvoltage, are extracted based on phase space reconstruction of voltage time series to identify different types of ferroresonance. Practical FOTS acquired from a transformer substation is used to validate the proposed method. Non-linear characteristic quantities obtained in this study can be applied to identify different types of ferroresonance. These characteristics allow further understanding of the non-linear ferroresonance phenomenon from another point of view and benefit the study of ferroresonance identification and suppression.


Background and Aim: Patients diagnosed with multiple myeloma and refractory to both proteasome inhibitors(PI) and immunomodulatory drugs (IMID) are in need of novel drugs. We aimed to analyze the efficacy and safety of daratumumab, a novel CD38-targeted monoclonal antibody, in Turkey. Patients and Methods: In this open-label, multicenter, early access program approach performed in 24 sites in Turkey, 39 patients (age ≥18 years) with multiple myeloma who were previously treated with at least 3 lines of therapy (including PI and IMID), or were refractory to both PI and IMIDs, were evaluated to receive intravenous daratumumab 16 mg/kg for 8 weeks (cycles 1 and 2), then every 2 weeks for 16 weeks (cycles 3-6), and then every 4 weeks thereafter (cycle 7 and higher). The primary endpoint was overall response rate (ORR)(partial response [PR] + very good PR + complete response [CR] + stringent CR). All patients who received at least one dose of daratumumab were included in the statistical analysis. Results: The first patient was enrolled in June 2016, enrollment was completed in January 2017 and follow-up is ongoing. Findings are reported for the 39 patients who met eligibility criteria (Table 1). Patients had received a median of 5 previous lines of therapy (range 3-8) and autologous stem cell transplantation (79,5 %). Median duration of Daratumumab treatment was 5.5 months (range: 0.2-13.2). 11 patients are still on treatment. Daratumumab was well tolerated; thrombocytopenia (11 [28.2%]), fatigue (10 [25.6%] patients) and anemia (10 [25.6%]) of any grade were the most common adverse events. No drug-related adverse events led to treatment discontinuation. ORR was noted in 14 patients (35.9%, 95% CI: 20.8-50.9) (CR:2 (5.1%, 95% CI: 0.6-17.3), VGPR: 1(2,6%) and PR:11 (28.2%, 95% CI: 15.0-44.9). The median time to first response was 1·0 month (range 0.5-7.5) (Figure 1). Median duration of response was 4.9 months (95% CI: 4.37-7.77) and progression-free survival was 5.5 months (95% CI: 2.2-8.8). 28 patients progressed on treatment. Thirteen of these patients died due to infections and progression. The 12-month overall survival is 56.9%. Conclusion: This multicenter Daratumumab monotherapy study showed encouraging efficacy in heavily pretreated and refractory myeloma patients with a favorable safety profile. However, there is a need to improve the response by combining with i.e. IMID and/or PIs. Acknowledgement: We are thankful to centers (Anadolu, Pamukkale, Cukurova, Adana Baskent, Dokuz Eylul, Erciyes, Karadeniz, Ankara, Acibadem Atasehir, Florence Nightingale, Istanbul University, Numune, Ataturk Hospitals) who enrolled less than two patients and could not be included among the authors. Disclosures No relevant conflicts of interest to declare.


Abstract
 This chapter describes the origin and introduction; climatic and site requirements, and other silvicultural characteristics; pests and diseases; natural regeneration; flowering, seed production and nursery conditions; provenance; taxonomy and distribution; timber and uses; yield and timber; and place of the following alder species in British forestry: Alnus cordata, A. glutinosa, A. incana, A. rubra, and A. viridis.


A 31-year-old male presented with a complaint of chronic pruritus with diffuse urticarial wheals for the past seven months. He underwent extensive workup and was found to have positive Helicobacter pylori (H. pylori) stool antigen test. He was treated with bismuth subsalicylate, metronidazole, tetracycline, and omeprazole for two weeks. Pruritus and urticarial wheals disappeared in four weeks after therapy was started.


The emergence of the theory of dynamic neural computing has made it possible to develop neural learning and adaptive schemes that can be used to obtain feasible solutions to complex control problems, such as inverse kinematic control for robotic systems. In this paper, such a neural learning scheme using a multilayered dynamic neural network (MDNN) is proposed. The basic dynamic computing element of MDNN is a dynamic neural unit (DNU) developed in this paper. The learning and adaptive capabilities of DNU can be used for developing complex dynamic structures. In this paper, we have used DNU for developing a MDNN for the inverse kinematic control of a two-link robot. The validity of the proposed scheme is demonstrated through computer simulation studies.