Aim: To assess the medium term survival and radiological outcome of primary cemented modular Freeman Samuelson total knee replacement at Dumfries and Galloway Royal Infirmary, UK Material and methods: 115 patients (118 knees), who underwent primary cemented modular Freeman Samu-elson total knee replacement from 1991 to1998, were reviewed retrospectively. Proximal cementing technique was used ti fix the metal backed tibial implant. The follow-up x-rays were also reviewed and presence of osteolysis, aseptic loosening and polyethylene wear was noted. The Knee Society radiological evaluation was used to record the osteolysis and the WOMAC score was used to evaluate functional outcome. Results: The operation was performed for osteoarthritis (87), rheumatoid arthritis (23), psoriasis (4), Pagets disease (2), avascular necrosis (1) and gout (1). The average follow-up was 7.25 yrs (range 5–13 yrs). At the latest review 25 patients had died and 14 had undergone revision surgery. The indications for revision were aseptic loosening and polyethylene wear (3), osteolysis (3), infection (6), instability (1) and loosening of patellar component (1). Patella was resurfaced in 80 patients using press fit uncemented all-polyethylene component. Two patients with unreplaced patella underwent re-operation for patellar resurfacing due to anterior knee pain. Cumulative survival of the implant at 10 years was 93.4% for revision due to aseptic loosening or osteolysis and 86.8% for revision due to any cause. Radiolucent lines were observed in 22 patients. In 4 of these patients, the radiolucent lines were progressive and 3mm or more in size. Osteolytic lesions were seen in 10 patients. None of the patients with osteolysis or radiolucent lines were symptomatic. There was no statistical association between thickness of polyethylene and presence of osteolysis or occurrence of aseptic loosening (chi squared test) Conclusion: Freeman Samuelson knee replacement provided good and predictable medium term outcome in our patients with tricompartmental arthritis of knee. The results of uncemented press fit all-polyethylene patellar replacement were also excellent. However, the high incidence of osteolysis even though asymptomatic, at an average follow-up of 7.25 yrs is a matter of some concern. Proximal cementing technique may lead to increased incidence of osteolysis and should be avoided in the modular Freeman Samuelson total knee replacement


This paper proposes significant route identification; the concept is to combine the locations acquired by the GPS module of the user's cellular phone. Significant routes are those that the user most frequently passes along. The proposal overcomes the two main weaknesses of cellular phones. One is that GPS data is acquired infrequently in order to reduce the phone's power consumption, and the other is the poor spatial accuracy of the cellular phone's commercial GPS module. In order to overcome these weaknesses, the proposed approach incrementally refines the stored routes whenever the user passes along them. In more detail, the system compares the newly acquired GPS points to the stored points and appends the new data so as to decrease route ambiguity. A experiment with 6 subjects over periods of 6-14 months demonstrates that the more often a user passes along a significant route, the more precisely the proposed approach can identify it.


Aims: To evaluate pregnant women with decreased fetal movements (DFM) identifying the risk factors and perinatal outcomes of such pregnancies. Study Design: A case-control study. Place and Duration of Study: Department of Obstetrics and Gynecology, Ekiti State University Teaching Hospital, Ado-Ekiti, between April 1 2017 and March 31 2018. Methodology: Women with singleton pregnancy presenting to the Department with complaint of DFM (cases) after 28 weeks of gestation were recruited and compared with women with no complaint of DFM that delivered in the facility during the study period. Sociodemographic data, obstetric characteristics. Antenatal risk factors, mode of delivery and perinatal outcomes were obtained using a semi-structured questionnaire. Data collected were analyzed with SPSS and variables were compared using student t test and chi square or Fisher exact test while p value was <0.05. Original Research Article Aduloju et al.; AJPCB, 3(4): 8-16, 2020; Article no.AJPCB.62596 9 Results: Out of 1439 women in the third trimester during the study period, 117 women had complaint of DFM with a prevalence of 12.3%. There was no statistical difference in the sociodemographic characteristics between the two groups; P>0.05. The mean gestational age at presentation and delivery were significantly lower among women with DFM (31.95 ± 1.81 weeks versus 37.46 ± 2.98 weeks; P=0.001 and 35.05 ± 1.47 weeks versus 37.46 ± 2.98 weeks; P=0.001 respectively). More women with DFM significantly had preeclampsia and intrauterine growth restrictions (P=0.002), oligohydramnios (p=0.016), caesarean delivery (P=0.005) and SCBU admission (P=0.009). The mean birth weight and Apgar scores at 1 minute were significantly lower in women with DFM (2.64 ± 0.54 kg versus 3.25 ± 0.57 kg; P=0.001 and 7.13 ± 0.68 versus 7.42 ± 0.82; P=0.003 respectively). Conclusion: This study showed that women with DFM are a higher risk of operative delivery and poor perinatal outcome such birth weight and Apgar score. Maternal perception of fetal movements should form part of risk assessment during routine visits.


Crimes against Diplomatic Agents and other Internationally Protected Persons." 1 In the following lines an attempt shall be made to analyse these "Draft Articles " with a view to assessing their value as a future legal vehicle providing comprehensive rules to protect international officials against terroristic attacks.2 The reasons that precipitated the drafting of these articles are certainly known to the public. The current flood of terrorism has reached an unprecedented peak in all its manifestations and has resulted in a dramatic increase of incidents against international officials. The toll of deaths and kidnappings of diplomats or attacks against their persons appears to have activated the concern of the international community of States which, although divided on the overall problem of terrorism, has evidenced a particular interest in curbing terroristic incidents against such persons.


Assembly unit for a compact heating apparatus, comprising a pump housing (24) and an air separation plant, wherein a plate heat exchanger (5) connected to the back of the assembly unit and the pump tank (24) comprises at least a portion of the air separation device, wherein the pump box (24) at least protrudes into the plate heat exchanger (5) on one side, the cassette can be used so that the space beside or below the plate heat exchanger.


These guidelines are intended for people engaged in social development in developing countries and are interested in michinoeki (roadside stations) as a development tool, and for those who already plan to use michinoeki. The six technical notes of the guidelines discuss concepts and policies related to regional development and provide specific advice on planning of michinoeki, design and e valuation, coordination to build agreement among stakeholders, and sustainable operations of michinoeki.


c © 2005, 2007, 2008 IBM Corporation and others. All rights reserved. This program and the accompanying materials are made available under the terms of the Common Public License v1.0 which accompanies this distribution, and is available at http://www.eclipse.org/legal/cpl-v10.html Contributors: IBM Initial documentation IBM Documentation updated 2007-01-10 IBM Documentation updated 2008-03-02


(–)‐Epigallocatechin‐3‐gallate (EGCG) is the major active component of green tea. Increasing evidence has suggested that EGCG exhibits anti‐inflammatory, anti‐oxidant and immunosuppressive effects. In this study, we investigated the effect of EGCG on concanavalin A (ConA)‐induced hepatitis (CIH) in mice, a model of immune‐mediated liver injury in humans. We pretreated mice with EGCG before ConA injection, and then measured alanine aminotransferase (ALT) levels in plasma, inflammatory infiltration and hepatocyte apoptosis in liver. Potential therapeutic mechanisms were elucidated further by measuring several inflammatory mediators. Mice pretreated with EGCG exhibited much less increased ALT levels in plasma, reduced inflammatory infiltration and hepatocyte apoptosis in liver compared with control mice pretreated with vehicle solutions. We further investigated the mechanisms of the protective effects of EGCG. In EGCG‐pretreated mice, we found abrogated tumour necrosis factor (TNF)‐α and interferon (IFN)‐γ at both protein levels in plasma and mRNA levels in liver. At the same time, the concentration of nitrite in plasma and inducible nitric oxide synthase production in liver were both down‐regulated in these mice. Moreover, IFN‐inducible protein‐10 and macrophage inflammatory protein‐1α expressions in liver were decreased significantly. Therefore, EGCG is capable of regulating immune‐mediated liver injury in vivo. The protective effect depended on its suppressive effect on the production of important inflammatory mediators.


Interfered by a variety of emergencies, it is difficult for the parameters in traditional robustness testing model for 4G networks to change adaptively. This paper proposes a quantified robustness detection model associated with fuzzy theory for 4G network. On basis of new measures for robustness of 4G networks, accordance with efficiency of 4G networks and size of connectivity diagram in small areas, the paper computes the associated robustness of nodes in the region and completes robustness tests. Simulation results show that: the topology has important implications on robustness of 4G networks; in different interference environment, this method can preferably express robustness changes in 4G network topology.


The method of processing a multi-mode service in a broadcast digital television receiver and the receiver is proposed. When a channel change is attempted by a user, the transport stream is received via a tuner. The controller extracts the additional information from the transport stream of the received and checked whether the changed from the extracted sub information channel is accompanied by one of the at least one logical channel and a physical channel broadcasting a multi-mode service. If the channel has changed the broadcast channel of a multi-mode service, on the screen to inform the user about the at least one logical channel is displayed. Thus, the user can easily select the desired logical channels according to your preference. Tuner, a logical channel, a physical channel, a digital television receiver


Several experimental studies have reported thermally activated behavior of the mechanical response of solid Helium-4 which does not fit into the model of thermally activated Frenkel pairs in an ideal crystal. The purpose of the present work is to investigate how structural topological defects modify the response. Using quantum Monte Carlo Worm Algorithm, we study temperature dependence of fluctuations of the total number of particles in samples of hcp solid Helium-4 containing several types of dislocations. Such fluctuations can be described by the thermal activation law with the activation energy dependent strongly on the type of the dislocation and the crystal density. The extracted values cover a range from about 1K to 20K. It is also found that annihilation of a jog-antijog pair can produce a local region of the solid characterized by the orthorhombic symmetry. This serendipitous observation suggests that hcp solid Helium-4 can undergo a displacive phase transition into the orthorhombic crystal under uniaxial stress of about 10-15%


Foreword Neil Levy Introduction James J. Giordano 1. Developments in neuroscience: where have we been, where are we going? D. F. Swaab 2. Origins of the modern concept of neuroscience: Wilhelm Wundt, empiricism, and idealism - implications for contemporary neuroethics Niko Kohls and Roland Benedikter 3. On the cusp: the hard problem of neuroscience and its practical implications Ralph D. Ellis 4. The mind-body issue Dieter Birnbacher 5. Personal identity and the nature of the self Paolo Costa 6. Religious issues and the question of moral autonomy Antonio Autiero and Lucia Galvagni 7. Toward a cognitive neurobiology of the moral virtues Paul M. Churchland 8. From a neurophilosophy of pain, to a neuroethics of pain care James J. Giordano 9. Transplantation and xenotransplantation: ethics of cell therapy in the brain revisited Gerard J. Boer 10. Neurogenetics and ethics: how scientific frameworks can better inform ethics Kevin FitzGerald and Rachel Wurzman 11. Neuroimaging: thinking in pictures John VanMeter 12. Can we read minds? Ethical challenges and responsibilities in the use of neuroimaging research Eric Racine, Emily Bell and Judy Illes 13. Possibilities, limits, and implications of brain-computer interfacing technologies Thilo Hinterberger 14. Neural engineering: the ethical challenges ahead Bert Gordijn and Alena M. Buyx 15. Neurotechnology as a public good: probity, policy, and how to get there from here Alexis M. Jeannotte, Kathryn N. Schiller, Leah M. Reeves, Evan G. DeRenzo and Dennis K. McBride 16. Globalization - pluralist concerns and contexts: shaping international policy in neuroethics Robert H. Blank 17. The human condition and strivings to flourish: treatments, enhancements, science and society Adriana Gini and James J. Giordano 18. The limits of neurotalk Matthew B. Crawford Afterword Walter Glannon Index.


Chlamydia trachomatis(CT) is currently the most common sex transmitted disease pathogen world-widely,which is an important reason of lower genital tract infection as well.However,the Chlamydia trachomatis infection is always asymptomatic and the clinicians did not pay adequate attention on it.Also it needs advanced lab equipments and techniques in detecting and screening the population with high risks and the follow-up and treatment is also lack of attention.Women infected with Chlamydia trachomatis suffer from the damages of the pathogen itself and the immune reactions it caused,such as miscarriage,fetal growth restriction,fetal distress,pre-rupture of membrane,preterm labour,low body weight neonate,still birth,intra-uterine infection,infection of neonate and the puerperal infection and post partum haemorrage.So purposeful screening and treatment towards Chlamydia trachomatis infection are important to reduce the complications of both maternal and fetal.


Purpose
The purpose of this study is to reveal the mechanism of humble leadership inducing abusive supervision from the low-status compensation perspective, examining the mediation role of leader perceived thread to status. Besides, the moderation effect of regulatory focus on the mediation path is discussed.

Design/methodology/approach
This study conducted a three-wave longitudinal survey. The data was collected from 438 leaders and their employees in five Chinese enterprises. This study used Mplus 7.4 and adopted a bootstrapping technique for data analysis.

Findings
Humble leadership has a positive effect on leader perceived threat to status. Leader perceived threat to status plays a mediation role between humble leadership and leader abusive supervision. Leader regulatory focus is the "gate valve" that humble leadership fosters leader abusive supervision. That is, when the leader promotion focus is high, leader perceived threat to status bred by humble leadership is low, resulting in less abusive supervision. When the leader prevention focus is high, humble leadership brings relatively more abusive supervision through perceived threat to status.

Originality/value
This study explores why humble leadership breeds abusive supervision behaviors and reveals the mechanism behind the negative effect of humble leadership based on low-status compensation theory. This study not only promotes the continuous development of the field of humble leadership research through empirical research but also provides guidance for effectively suppressing the negative effects of humble leadership, promoting strengths and avoiding weaknesses and suppressing inappropriate management behaviors in management practice.


SUMMARY Growth and flowering studies were made for three years on the mango varieties Dashehari Langra and Nisar Pasand. The main growth periods were March July, March July and February-November respectively, with a peak in June for Dashehari and May for Langra, but Nisar Pasand showed no such peak. Flowering on shoots within one year of the previous flowering was recorded on 73 per cent of Nisar Pasand shoots, 38 per cent with Langra and 6 per cent with Dashehari. Nisar Pasand was shown to be a regular bearer.


Two groups of pumps were investigated in great detail and the analysis showed that large variations in QcR, for the same design specific speed, can be obtained by modifying the design of the rotating channels . An attempt was made to condense the different design parameters into a global parameter, relating the design con cept and the critical flow rate, for analysis and prediction purposes .


Caregivers of children with special needs experience a high workload, which causes stress and low quality of life. A compassionate love attitude amongst caregivers is needed to improve the quality of parenting. This study aims to develop a compassionate love parenting training program to reduce stress among children with special needs caregivers. The method employed was Pre-experimental Design, with One-group Pre-test-Post-test. The research participants were 40 caregivers identified using the purposive sampling technique. In the pre-test, the stress level of the caregivers was measured using the Parental Stress Scale with 24 items (α = .828). The data were analyzed using the Wilcoxon test to observe the differences between the pre-test and post-test of two dependent samples. The results show that the stress score decreased significantly, with Z = -2.023 and with a significance level of .043 .05. It is demonstrated that regular training in compassionate love parenting reduced the stress felt by caregivers of children with special needs. The implementation of compassionate love parenting training in special needs therapeutic centers is important, as it is one of the intervention methods that has been proven to reduce the level of stress to optimize the growth of the child.


According to the dictionary, "Predatory" means 'anything that is inclined or intended to injure or exploit others for personal gain or profit.'[1] Predatory journals and publishers, a global threat, characteristically are entities prioritizing self‐interest at the expense of academic scholarship; and their attributes are false or misleading information, deviation from good editorial and publication practices, lack of procedural transparency, and/or use of intense and indiscriminate canvassing practices.[2] A predatory journal's website or e‐mails usually exhibit contradictory statements, false impact factors, incorrect and/or misrepresented editorial board details, false indexing details, and misleading claims about their peer‐review process with an overall unprofessional and poorly drafted web page.[2] Online predatory publishers take advantage of the 'Gold Open Access' model wherein the publication processing charges become their source of income rather than the journal subscriptions.[3] Not only naive researchers but established ones also fall victim to predatory journals. An over‐emphasis on publications for academic and professional advancement is an important contributor to the surge in predatory publishing. Therefore, the problem is not only with the publishers but also with academicians who find publishing in such journals easy and fast so as to obtain their career recognitions.[4] Although authors have suggested excellent criteria to identify predatory journals,[5] it still remains significantly challenging to differentiate newly emerging journals which use questionable methods to attract submissions and frequently lack an appropriate professional outlook.


Energy conservation plays a role important in wireless sensor network (WSN) design. The technique of clustering is one of the approaches to save energy of WSNs; several protocols based on the clustering technique are proposed in the context of energy conservation and maximization of network lifetime. This article proposed a new routing technique to maximize the network lifetime and enhance energy efficiency in WSNs, namely optimal selection of cluster head in the grid (OSCH-Gi). This technique divides the network area into a clustered grid. Each clustered grid has a cluster head (CH) it has been chosen based on the residual energy and distance to the base station of each node. Simulation results indicate that the proposed technique is more effective than other clustering algorithms in terms of the network lifetime and energy consumption.


Disclosed are a light guide plate and an LED lamp. The lamp comprises: an installation base (7), an LED light board (10) and at least one light guide substrate (2), wherein the light guide substrate (2) has a light incident side wall corresponding to an LED light-emitting unit (11), and there is at least one side wall intersected with the light incident side wall on the light guide substrate (2) having several continuous or discontinuous diffuse reflection points. Providing diffuse reflection points or particles to enable light to be emitted from the light guide substrate (2) results in a simple technology, a high production efficiency and an effective cost saving; moreover, the diffuse reflection points can form any pattern, i.e. the light-emitting pattern of the light guide substrate (2) can be optionally set.


This paper describes dynamic performance analysis of Unified Power Flow Controller (UPFC) composed of cascaded H-bridge and single-phase multi-winding transformers for isolation. The operational characteristic was analyzed through simulations with PSCAD/EMTDC, and experimental works with a scaled model. The UPFC proposed in this paper can be directly connected to the transmission line without series injection transformers. It has flexibility to expand the operation voltage by increasing the number of H-bridges. Copyright © 2007 John Wiley & Sons, Ltd.


Loss of vision describes a reduction in vision that cannot be corrected by glasses or contact lenses. Patients who complain of changes in their vision may have loss of visual acuity, distorted vision, or visual field loss. The World Health Organization classifies visual impairment as blindness or low vision. Blindness is defined as visual acuity of less than 3/60 in the better eye. Low vision is present when the visual acuity is less than 6/18 but equal to or better than 3/60, in the better eye. The etiology of permanent visual loss is diverse and depends on the region studied. In the UK, the leading causes are age-related macular degeneration, glaucoma, diabetic retinopathy, optic atrophy, and cataract. This chapter describes the clinical approach to the patient with loss of vision.


Two dimensional anomalous small-angle scattering measurement at K absorption edge of Mg has been successfully demonstrated for concentrated Al-Mg binary alloys and MgO nanoparticles. Enhancing the contrast between Mg-rich precipitates and Al matrix was explained by the anomalous dispersion of Mg, and anisotropic SAXS pattern was in good agreement with the microstructure observed by transmission electron microscopy. Agreement of atomic scattering factor obtained from Al-Mg and MgO nanoparticles indicates that the origin of SAXS in the present Al-Mg alloys are Guinier-Preston zones, not the voids that grew from supersaturated vacancies.


Background and objective: The use of antibiotics in acute pancreatitis despite recent clinical trials remains controversial. The aim of this study is to review the latest clinical trials and guidelines about antibiotics in acute pancreatitis and determine its proper use. Methods: Through a Medline search, we selected and analyzed pertinent randomized clinical trials and guidelines that evaluated the use of antibiotics in acute pancreatitis. We answered the most frequent questions about this topic. Results and conclusion: Based on these clinical trials and guidelines, we conclude that the best treatment currently is the use of antibiotics in patients with severe acute pancreatitis with more than 30% of pancreatic necrosis. The best option for the treatment is Imipenem 3 × 500 mg/day i.v. for 14 days. Alternatively, Ciprofloxacin 2 × 400 mg/day i.v. associated with Metronidazole 3 × 500 mg for 14 days can also be considered as an option. Review Severe acute pancreatitis (SAP) as defined by the Atlanta criteria, is present in up to 25% of patients with acute pancreatitis (AP) [1], with mortality of 10%–20%. In these patients, AP develops in two phases: the first ten days are characterized by the systemic inflammatory response syndrome (SIRS), whereas in the end of the second week infection complications begin to appear [2]. These complications due to infection are responsible for up to 80% of deaths in patients with AP. About 40% to 75% of patients with pancreatic necrosis develop infection, 24% after the first week and 71% after the third week [3,4], with mortality rates up to 50% [5,6]. The mechanisms of infection in AP are bacteria translocation, via lymphatic, via hematogenic, and reflux from duodenum and biliary tree as well [7]. If the major problem in AP is infection of pancreatic necrosis, it makes sense to consider that the use of antibiotics in this situation could reduce the morbidity and mortality of these patients. However, at present there are still controversies about this topic. Therefore, some questions remain unclear regarding the use of antibiotics in AP: 1-Should we use antibiotics in Acute Pancreatitis?


Biometrics, as an intelligent and secure authentication method, has recently become increasingly popular. Modern society uses fingerprints, iris and face recognition on a daily basis, even on a large scale; for example, in biometric passports. However, there are still other biometric traits that may provide sufficiently high accuracy but have not been widely implemented so far, e.g. palmprints. In this article, we propose a novel human-centred method of palmprint-based user verification. The proposed method is dedicated to the mobile devices and provides the accuracy reaching 94.5%. Moreover, the method is time-computing efficient and gives the response in less than 0.2 s. All the experiments described in the article were performed using the benchmark PolyU database and three widely available mobile phones.


Objective: In molecular endocrinology, techniques such as polymerase chain reaction (PCR), real time PCR, and DNA sequence analysis are of enormous importance for diagnosing inherited and somatic mutations that are related to disease. The adequate isolation of nucleic acids from peripheral blood, stained slide cells from fine-needle aspiration, fresh and formalin-fixed/paraffin-embedded tissues is crucial to ensure the success of these techniques, especially when samples have been stored for long periods or when no other samples can be collected from patients who were lost to follow-up. Here, we evaluate several procedures for improving current methodologies for DNA (salting-out) and RNA isolation. Methods and results: We used proteinase K treatment, heat-shock and other adaptations to increase the amount and quality of the material retrieved from the samples described above. Conclusion: We successfully isolated DNA and RNA from such samples, and this material was suitable for PCR, methylation profiling, real-time PCR and DNA sequencing analyses for molecular diagnoses.


In the reported study, thin films of ZnO doped with 10 wt. % Co were fabricated by pulsed laser deposition under different oxygen partial pressures. The results of x-ray photoelectron spectroscopy show that the valence state of the Co ions is 2+ and that the number of oxygen vacancies is increased by lowering the oxygen partial pressure during deposition. The results of UV–visible absorption spectroscopy show that the Co2+ ions substitute for the Zn sites in the ZnO lattice. Ferromagnetism in the Co-doped ZnO thin films is observed up to 300 K. Furthermore, the saturation magnetization increases as the oxygen partial pressure decreases, indicating a strong correlation between the number of oxygen vacancies and the saturation magnetization. This suggests that ferromagnetism in Co-doped ZnO can be enhanced by simply controlling the oxygen partial pressure that causes oxygen vacancies. Furthermore, how the mechanism for the expression of ferromagnetism can be explained by the bound magnetic polaron model is discussed.


A new corpus project of the National Institute for Japanese Language and Linguistics is building a large-scale corpus of everyday Japanese conversation, the Corpus of Everyday Japanese Conversation, CEJC, which contains various kinds of conversations in a balanced manner. We plan to publish the corpus with 200 hours of conversations in 2022, and have already published and released 50 hours of the conversations to the public on a trial basis in December 2018. In this paper, we investigate statistically prosodic diversity in everyday conversation by analyzing the characteristics of the fundamental frequency (F0) of utterance in the CEJC. We first examined the differences of the F0s by the relationships between the speaker and the addressee. The results indicated that speech to the family is generally produced with low F0s, and politeness to the addressee produces higher F0s in utterances. Next, we analyzed the characteristics of the F0s in situations with various types of participants to show the effect of participants on diversity. The results indicated that although the degree of the F0 change differs with each speaker, they speak in relatively low tones in situations including family members and utter with high F0 in customer service.


The India-based private-sector financial institution Axis Bank demonstrated its triumph moving into the investment-banking business by acquiring the privately owned Enam Securities. Indeed, Axis considered that the Enam deal would generate superior cash flows in the growing competitive prolific business, that is, financial advisory services. In other words, the merger with Enam was only a forward integration, which might help in collecting a fee-based income and advisory fee that strengthens future earnings. Axis shareholders were poignant when the corporate board declared a merger announcement with Enam. In this regard, had they been influenced by new market information, which was formally a merger announcement? Likewise, did Axis shareholders benefit from this merger? Will Axis sustain their acquired business in the growing advisory services? How did Axis benefit from the non-compete agreement with Enam? More importantly, will they produce superior future free cash flows? In addition, students would learn various motives behind bank mergers in India and business opportunities in investment banking. Specifically, students would acquire hands-on experience related to the estimation of future free cash flows and business valuation. List of supplementary materials: Teaching note, exercises with solutions (spreadsheets are available upon request).


The Influence of acid basicity to hydrogen peroxide solution manufacture was analyzed, and the right control methods were pointed out.


Recent research in rural workforce issues has identified professional isolation and barriers to further education as major impediments in attracting and retaining skilled staff in a range of professions in the rural health system (Brown 1992; Schofield 1992). The seminar, Planning to manage and managing to plan, organised by the Rural Health Special Interest Group of the NSWHIMA, provided an opportunity to address some of these issues for rural NSW HIMs.


Chimeric antigen receptor (CAR) Ts have been effective in pre-B ALL, but their efficacy in AML has yet to be established. A significant barrier to effective CAR T therapy for AML is the substantial overlap of cell surface antigens expressed on AML and normal hematopoietic cells. To overcome this barrier, we profiled the transcriptome of over 3000 AML cases in children and young adults and contrasted this to normal hematopoietic tissues in search for AML-restricted targets (high expression in AML, silence in normal hematopoiesis). This led to the discovery of over 200 AML-restricted genes. Of these, Preferentially Expressed Antigen in Melanoma (PRAME) is among one of the highest expressing AML-restricted genes (Figure 1A) and, given its previous track record as a target for a variety of cancers, we selected this target for further assessment and therapeutic development in AML. However, PRAME is intracellular and therefore is inaccessible for targeting with conventional CAR T. Recently, a novel approach to target intracellular antigens was developed using TCR mimic (mTCR) antibodies, which recognize peptide/human leukocyte antigen (HLA) complexes on the tumor cell surface in a similar mode of recognition as authentic T Cell Receptors (TCRs). The Pr20 antibody was developed to recognize the PRAME ALY peptide in the context of HLA-A*02. Utilizing this Pr20 antibody, we developed a mTCR CAR T targeting PRAME and evaluated its preclinical efficacy in AML.
 The VL and VH sequences from Pr20 were used to construct the single-chain fragment variable domain of the 41-BB/CD3ζ CAR vector. We evaluated PRAME mTCR CAR T cells against OCI-AML-2 and THP-1 AML cell lines (PRAME +/HLA-A*02 +), K562 CML cell line (PRAME +/HLA-A*02 -) and HEK293T (293T) (PRAME -/HLA-A*02 +). Using a PE-conjugated Pr20 antibody, we confirmed that OCI-AML2 and THP-1 express PRAME ALY: HLA-A*02 but not K562 and 293T by flow cytometry (Figure 1B). As further confirmation, AML blasts in primary patient samples also stained with the Pr20 antibody (Figure 1C). For in-vivo studies, leukemia-bearing mice were treated with unmodified T or PRAME mTCR CAR T cells at 5x10 6 cells (1:1 CD4:CD8) per mouse 1 week following leukemia injection. Leukemia burden was measured weekly by bioluminescence IVIS imaging. Cells were treated with 10ng/mL of IFN-γ prior to co-incubation with T cells for 16 hours.
 PRAME mTCR CAR T cells demonstrated potent cytolytic activity against OCI-AML2 and THP1 but not against K562 or 293T cells, following co-incubation with target cells for 24 hours (Figure 1D). Consistent with potent, target-specific reactivity against PRAME ALY: HLA-A*02 positive cells, increased levels of IFN-γ, IL-2 and TNF-α were detected in cocultures of CAR T cells with OCI-AML2 and THP1 but not with K562 and 293T cells (Figure 1D). The cytolytic activity of PRAME mTCR CAR T cells extended to primary AML specimens expressing the PRAME ALY: HLA-A*02 antigen (data not shown). In-vivo efficacy of PRAME mTCR CAR T was demonstrated in OCI-AML2 and THP-1 CDX models (Figure 1E). Treatment with CAR T cells induced leukemia clearance and significantly reduced leukemia burden in OCI-AML2 and THP-1 xenograft mice, respectively, while treatment with unmodified T cells exhibited leukemia progression (Figure 1E). The anti-leukemia activity of CAR T cells resulted in enhanced survival in OCI-AML2 (p=0.0035) and THP-1 (p=0.0047) xenografts (Figure 1F). The in-vivo activity of PRAME mTCR CAR T cells was target specific, as treatment with CAR T cells did not affect leukemia burden and survival in K562 xenograft mice (Figure 1F). Given that IFN-γ promotes PRAME presentation, we investigated whether treatment of IFN-γ would enhance cytolytic activity of PRAME mTCR CAR T cells. OCI-AML2 and THP-1 cells pretreated with IFN-γ were more sensitive to cytolysis compared to untreated controls (Figure 1G).
 In this study, we demonstrate the therapeutic potential of targeting PRAME with mTCR CAR T cells in AML. We show potent, target-specific reactivity of PRAME mTCR CAR T cells against PRAME ALY: HLA-A*02 positive AML cells, both in-vitro and in-vivo. We further demonstrate that the activity of PRAME mTCR CAR T cells can be enhanced with IFN-γ treatment, providing a useful strategy to increase efficacy. Thus, the results presented provide a novel approach to target PRAME with CAR T cells and compelling data to evaluate PRAME mTCR CAR T cells in AML clinical trials.
 Figure 1 Figure 1.

 Pardo: Hematologics, Inc.: Current Employment. Hylkema: Quest Diagnostics Inc: Current equity holder in publicly-traded company; Moderna: Current equity holder in publicly-traded company. Scheinberg: Eureka Therapeutics: Current equity holder in publicly-traded company.


This study aims to obtain empirical evidence about the effect of taxpayer awareness and tax sanctions on taxpayer compliance in paying land and building taxes in Bukit Kecil sub-district of Palembang. The population in this study is the land and building tax (PBB) that have been registered in Bukit Kecil District in 2017 as many as 8,596 people. Meanwhile, the sample in this study were 99 respondents. Data collection methods used in this study are by distributing questionnaires to respondents and using a likert scale. The data in this study were processed using Statistical Product and Service Solutions (SPSS) version 22 and using quantitative analysis. The results of this study indicate that taxpayer awareness and tax sanctions have a positive and significant effect on tax compliance in paying land and building taxes in Bukit Kecil sub-district of Palembang.


The efficient service rendered by the speciality in formation of the journal reference room depends on the quality and range of the information resources development,like the sense of active service,the service of the choice of subjects,the consulting service,etc.Teachers and scientific research personnel can be quickly and efficiently provided with differcnt kinds of information


A fast scale of four has been developed in which the emphasis has been on reliability. Since the scale of two units employ diode clamping to limit the plate and grid voltage excursions, the most important requirements are (1) proper choice of grid clamping voltages, (2) the grid swing without grid clamping should be considerably larger than and symmetrical about that obtained with grid clamping. To satisfy these and other requirements, metallic film precision resistors are used extensively, and the critical bias voltages are controlled by compensating networks. The resolving time for 3 or more evenly spaced trigger pulses is about 0.06 microsecond. Pulse heights ranging from 6 to 15 volts may be used.


Through the test by using surface ionitriding processing technology to 27SiMn materials,we studied the corrosion resistance、friction of resistance、microstructure and rigidity of 27SiMn materials、aspects of the specimen deformation and the advanced nature of the liquid compared with the traditional plating.The experimental results of the surface proved that the surface ionitriding processing technology is an advanced corrosion resistant technology and it's corrosion resistance is better than that of liquid chrome.Especially the process of production is simple,processing cost is low and no pollution on the environments.


Abstract : Conducting polymers have received extensive attention recently, but a few traditional problems such as the need for toxic dopants, material intractabilities, and poor environmental and oxidative stabilities still exist that severely plague the field. Although most work on solving these problems has been based on electron transfer as a doping mechanism, we have defined a new mechanism based on Proton Abstraction Dopind (PAD), which has eliminated many of the above problems but has created several of its own. Our previous work has centered on abstraction of doubly benzylic and/or allylic protons with strong base, but both the use of strong base and the resulting reactive anion make this a difficult system to handle in the air. Preliminary results show that the incorporation of electron withdrawing nitro groups into these materials seems to overcome this problem.


The buildup of magnetic flocs containing plankton on a single wire by means of magnetic seeding method is studied for the axial flow configuration. The species of plankton, magnetic seeding material, and flocculant used in this experiment are Chattonella sp., magnetite, and polyaluminum chloride (PAC), respectively. When magnetic field intensity increases, PAC concentration decreases or magnetite concentration increases, the buildup changes from one without chains similar to that of paramagnetic particles, to one with needle-like chains similar to that of ferromagnetic particles. The former is found to be adequate for the recovery of plankton. For this case, the optimum PAC concentration is 100 mg/1. The normalized accumulation radius R a as a function of time t is expressed by the equation R a 2=At+1 for the buildup without chains. The value of A depends on PAC concentration and magnetic field intensity.


In this contribution we present the results of computer simulations as well as real experiments which all confirm the correctness of amendments to what is known as the Barkhausen criterion, necessary for its further application in practice [1]. The Barkhausen criterion for the formation of steady state harmonic oscillations is, due to its simplicity, very often used in the design of oscillators with feedback. In the literature, however, there are examples of oscillators that, even when this condition is met, do not oscillate at the desired frequency. In this paper we show in a suitable type of oscillator that for the emergence of harmonic oscillations, additional necessary condition of negative derivative of phase vs. frequency characteristic of the open loop feedback oscillator is needed. If this condition is not met, steady state oscillations may not exist, even if one may expect their existence from the Barkhausen criterion. Moreover, in some types of feedback oscillators, relaxation oscillations may occur at different frequencies as well. For verification of the additional condition, we proposed a proper RLC band pass filter, by means of which it is possible to easily change the sign of the derivative of the phase vs. frequency characteristic.


Observations of modifications of the electron temperature in the F-region produced by powerful high-frequency waves transmitted in X-mode are presented. The experiments were performed during quiet nighttime conditions with low ionospheric densities so no reflections occurred. Nevertheless temperature enhancements of the order of 300-400K were obtained. The modifications found can be well described by the theory of Ohmic heating by the pump wave and both temporal and spatial changes are reproduced. A brief overview of several different experimental campaigns at EISCAT facilities in the period from October 2006 to February 2008 are also given pointing out some interesting features from the different experiments. The main focus is then on the campaign during October 2006 and modifications of the electron temperature in the F-region.


Over the centuries, first Latin and then French, German, and Russian have receded in perceived importance as languages of science. Other powerful languages with extensive internal scientific discourse, such as Japanese and Chinese, have always been largely excluded. The dominance of English has elevated the reputation of English-language universities and advantaged native speakers of English by creating a self-reinforcing loop of language flow. Abstracting services insist on English-language abstracts; citation indexes often include only English-language citations; thus English appears to dominate scientific discourse, and English-speaking universities invariably head the lists of leading scientific institutions. The inexact assumption appears to be that, with enough pressure, others will be forced to learn English in order to compete. Thus scientific advancement circumscribed by the English language is erroneously equated with scientific advancement in general. If this discriminatory situation is to change, the advantaged must acknowledge their advantage and explore ways of redressing the imbalance.


The concept, design, and experimental characterization of a novel micropump based on the temperature dependence of liquid viscosity is described. Since the difference in flow resistance generated by local heating of the liquid in narrow channels is used for rectification of the flow, the pump is free from mechanically movable valves while attaining high controllability. Small size is important in making this principle work effectively, as well as reducing the complexity of thermal and fluidic design. An experiment using a prototype device fabricated by silicon-based micromachining demonstrated the linear relationship between flow rate and the duration of heating, and the capability of bi-directional pumping.


The article contains experimentally obtained dependencies that by common usage permit to predict the mechanical properties of the metal as after a cycle of cold pilger rolling, and along the length of the deformation zone. These dependencies link specific strain parameters to found criterion of changes in mechanical properties. The final dependences and technique for predicting of changes of the properties were experimentally verified.


6541 Background: VNP40101M is a novel sulfonylhydrazine alkylating agent with significant activity in refractory AML. In a phase I single agent study of pts with relapsed/refractory leukemias, the ...


Selected hazelnut crossbreds as tested samples,analyzed nitrogen,phosphorus,potassium and calcium content periodically and correlation between them.The results showed that as for fruit and kernel,N,P;N,K;P,K were significantly positively correlated or very significantly positively correlated,for kernel,P,Ca,K,Ca were significantly positively correlated or very significantly positively correlated.N,K and Ca in kernel and fruit were significantly positively correlated or very significantly positively correlated,N in kernel and shell was very significantly negatively correlated and Ca was significantly positively correlated.In kernel and fruit as well as in kernel and shell,P was irrelevant.


The outbreak of severe acute respiratory syndrome (SARS) was first recognized in China, November 2002 and subsequently spread worldwide. We report a case of a patient from Singapore who developed atypical pneumonia and was treated in Frankfurt, University Hospital. Electron microscopic analysis was carried out by using negatively stained samples of throat swabs, sputum, naso-pharyngeal aspirates, blood, serum and broncho-alveolar lavage (BAL). Additionally, BAL was analysed using ultrathin sections embedded in Epon and in LR Gold. Analysis of negatively stained samples of throat swabs revealed paramyxovirus particles (Fig. 1 A). Analysis of sputum, BAL and blood serum further revealed bacteria-like particles, 130300 nm in diameter. Cells in the BAL showed severe infection of cells with bacteria that reacted in immunofluorescence analyses with antibodies directed against Chlamydia pneumoniae. In electron microscopy, Chlamydia were located in big intracellular vacuoles and displayed variable size and appearance (Fig. 1 B). Two morphologically different developmental forms and multiple intermediates were recognized. One was a small cell about 100 to 300 nm in diameter, with an electron dense matrix. The other was a large cell, 300 to 600 nm in diameter, with either patches of electron dense material or without a dense centre. Morphology of detected structures was coincident with reticulate bodies and elementary bodies of Chlamydia. Quantification of infected cells showed that more than 66% of BAL cells were infected with Chlamydia. Main targets were alveolar macrophages, 86% of them were infected. Epithelial cells (alveolocytes II type) and neutrophils were infected with Chlamydia, as well.


The paper analyzes the main problems of Chinese present tax system on insurance and argues that it would hinder the development of insurance.The author puts forward some suggestions of tax system reform such as: to adjust and reduce taxation on insurance to enhance the incentive of insurance for purpose of promoting the development of insurance.As a result,the reformation can help the insurance industry to play a more important role on the public welfare.


Although recent U.S. legislation has had a profound impact on reading instruction and student achievement, some students continue to fall behind. This provocative text addresses this gap with a new perspective on reading instruction that goes beyond the realms of teacher content knowledge and methodology. You'll learn how motivation and interest can enhance reading instruction for all students - and you'll get strategies to increase reading success.


15 adolescent and postadolescent females who had been exposed to stilbestrol prenatally were thoroughly examined and biopsied. Their ages ranged from 15-23 years. At least 4 nonmalignant lesions not previously noted in such patients occurred with high frequency and were thought to be related to the use of stilbestrol. The lesions were an upper vaginal hood a strawberry cervix and cervical portio cocks comb and an endocervical tumor formation. These lesions can be palpated with 1-finger examination. No relaionship of these lesions to adenocarcinoma was demonstrated but there is a definite need for further followup of these patients and others similarly exposed. Adenocarcinoma was seen in 1 patient. This patient underwent a radical hysterectomy and total vaginectomy pelvic node dissection and graft replacement of the vagina. All of the nodes were free of tumor. The patient did well except for persistent urinary retention and urinary tract infection which eventually resolved with treatment. The patient remains well after 1-1/2 years. Granular appearing posterior fornix was seen only once and biopsy demonstrated acute and chronic vaginitis. No instance of vaginal adnosis was seen except in the patient with adenocarcinoma.


This study was performed to evaluate the effectiveness of functional neck dissection in controlling metastasis to the clinically negative (cNO) neck, focusing on recurrences in the pathologically negative (pNO) neck and the role of extracapsular spread in the cNO neck. A series of 172 patients (253 dissected fields) treated for cNO laryngeal or hypopharyngeal cancer with a 5-year minimum follow-up is presented. Occult metastasis was observed in 30% of the patients. Extracapsular spread was present in 39% of the positive nodes. The neck recurrence rate was 5.2%. Surgical specimens from cases of neck recurrence in pNO necks were reevaluated for micrometastasis by immunostaining with antibody for cytokeratins. The immunohistochemical findings were positive in 1 of 4 cases. Functional neck dissection provides good neck control and survival rates for the cNO neck. The accurate prognostic significance of extracapsular spread in cNO necks is still unknown. Micrometastasis alone may be insufficient to explain recurrences in pNO necks.


The Australian Book Design Awards is an annual exhibition encouraging Australian publishers and printers to produce the best designed books. Technology has changed the focus of what can be entered into the Awards today and the honesty of the judges has both chastised and rewarded, and significantly influenced the direction of Australian design.


The economic development efforts of the Papua province should focus on increasing employment opportunities and increasing investment as a stimulus to economic growth, thereby distributing community opportunities in every productivity Can be acquired for community welfare and economic development. Therefore, each autonomous region has the freedom to develop all potential and assets owned, especially the potential of natural resources that can be used as a mainstay asset in the development of regional economies in general. Therefore, it is necessary to analyze how the influence of Labour (Human Capital) and the power of investment in economic growth in Papua province (case study). The results showed that: the provision of employment opportunities in the Papua province is influenced by investment and real investment affects the provision of employment opportunities. This is because there is a lot of investment supported by the Government through a development financing budget that use more oriented to the development of sectors that are less absorbing workforce. Investment and Labour, both have no positive effect on the percapita income and economic growth.


The collaborative work between FRP plate and concrete is achieved through the binder, so the interface of them is the weak links. Under external loading, the relative slip occurred on the interface between FRP plate and concrete causes the redistribution of stress and then the bearing capacity of the member will be reduced. Especially the FRP plate is a kind of resin material and its physical and mechanical properties will change with temperature and time. Based on energy variation principle, the differential equations of interfacial shear stress meanwhile to considering temperature and creep effect of concrete beams strengthened with FRP plate are established, in which the strain-energy of concrete beam, FRP plate and glue layer are calculated. And the calculated formulas of interfacial shear stress for a single point load are given.


In two experiments pigs were individually and restrictively fed from approximately 24 to 83 kg liveweight. The diets consisted of wheats of varying protein content supplemented with four levels of soybean meal. In experiment 1, wheats of 19.2 per cent and 11.5 per cent crude protein were compared and in experiment 2, the per cent crude protein content of the wheats was 14.9 and 13.1. Average daily gains, feed conversion ratios and carcase characteristics were not significantly affected by source of wheat in experiment 1, whereas in experiment 2, the 14.9 per cent protein wheat resulted in average daily gains and feed conversion ratios significantly superior to the 13.1 per cent protein wheat. Average daily gains and feed conversion ratios in both experiments and carcase quality in experiment 2 improved with increasing level of soybean meal supplementation. The interaction of wheat source x soybean meal level was significant only for backfat thickness in experiment 2. The level of soybean meal at which backfat thickness significantly increased was 6 per cent and 3 per cent with wheats of 14.9 per cent and 13.1 per cent protein respectively. The observed growth performance and carcase quality between the wheats fed appeared to be unrelated to the determined essential amino acid content of the wheat.


The aim of this study is to propose preservation and management plan by reinterpreting the meaning of King Jeongjo's journey to HyunLeoungWon Tomb and the value of facilities that were built for the journey. The main object of this paper is to suggest the preservation plan of Siheung Road which was built in 1795 and facilities that connected to the street like HaengGung, Jeongja, bridge, etc. To pursue the purpose, the research data of the type and location of the facility were collected, and the value and characteristics of the main facilities were interpreted. In addition, the present condition and problems were analyzed, and a proposal for its conservation and management is made. This paper will finally extend the meaning of historical conservation not only to the physical condition but also to the non-physical boundary.


In this paper, we study the L2−L∞ filtering, also known as energy-to-peak filtering, for continuous-time Markov jump systems considering that the Markov chain cannot be directly measured. In this context, the filter has only access to an observed process related to the main jump process of the plant by means of an exponential hidden Markov model. Sufficient conditions for the design of full-order filters which impose the desired upper bond on the L2−L∞ ratio are given in terms of Linear Matrix Inequalities. The paper is illustrated by means of a numerical example.


OBJECTIVE
To observe the level of serum endothelin (ET) of interictal epilepsy patients with regional cerebral blood flow (rCBF) decreased foci in SPECT brain perfusion imaging and to investigate its value for diagnosis and differential diagnosis of epilepsy.

METHODS
Seventy-six interictal epilepsy patients were enrolled and SPECT brain perfusion imaging, EEG, X-CT or MRI were performed, with 25 healthy volunteers as controls whose serum ET levels were measured by radioimmunoassay.

RESULTS
The serum ET levels of 49 idiopathic epilepsy patients were significantly higher (P < 0.01) than that of healthy controls. The ET levels of 21 symptomatic epilepsy patients were not significantly different from that of the healthy controls (P > 0.05). The ET levels of 6 non-epilepsy patients were significantly higher than that of the healthy controls (P < 0.05).

CONCLUSION
The level of serum ET is of value to the differential diagnosis for interictal epilepsy cases, and can contribute to the qualitative diagnosis of idiopathic epilepsy.


A study of Xu Fu, the man, and his eastward voyage in terms of literature can beconcluded by the following observations: (1) Xu Fu was believed to be a descendent from the ShaoHao Family and later the kingdom of Xu. He was an alchemist at Langya and one of the "Qi people" in the later days of the warring kingdoms Age and in the Qin Dynasty; (2) Xu Fu's second and non-return eastward voyage is an intentional action for political refuge; (3) Xu Fu started out at Lanyao port between June and July of the 28th(219 B. C. )and the 37th (210 B.C. )of the Shihuang ace, Sailed on from island to island, and finally arrived at what is now the town of Shingu in the county of Wagayama of Japan; (4) Xu Fu brought the advanced material civilization in the Qin Dynasty to Japan by means of his eastward voyage,which was to develop in the Misheng culture.


The current study examined multiple features or phenotypes of non-suicidal self-injury (NSSI) in relation to broad external markers of severity. We examined associations between the number of NSSI acts or frequency of NSSI, onset age, number of methods, time between having an urge to self-injure and the act itself, desire to stop self-injuring, whether or not individuals typically experience pain during self-injury, and whether or not individuals are typically alone during self-injury, and NSSI severity. NSSI severity was indexed by measures of psychological distress. Analyses examined associations between each NSSI feature individually, as well as simultaneously, and depressive and borderline personality symptoms. The number of NSSI methods used was associated with both depressive and borderline symptoms across both univariate and multivariate models. Additionally, whether individuals typically experience pain during self-injury and whether individuals were typically alone during self-injury were each significantly associated with both depressive and borderline personality symptoms in univariate models. However, these associations were better accounted for by number of NSSI methods. Finally, onset age of NSSI was also associated with borderline personality symptoms in the multivariate model. Results suggest that the number of NSSI methods is most indicative of NSSI severity, when indexing severity by psychological distress.


Abstract:This article reports results of a study that investigated the relationship between leadership style and group cohesion in outdoor education. Two surveys were used with 359 participants, aged 13–15, who participated in a 4-day canoe trip on the Lower Colorado River. Results showed a statistically significant correlation between leadership and group cohesion, suggesting that (a) an understanding of a variety of leadership styles gives leaders the ability to shift their style according to each situation, (b) it is important for leaders to think about when to use different leadership styles, (c) awareness will make for more effective leaders, (d) leaders should avoid relying on a single style and trying to use it in all situations, and (e) an ability to use multiple leadership styles makes leaders more confident in their ability to facilitate group cohesion.


There is a standard method to use credit scoring to estimate borrowers' creditworthiness in a bank's consumer loan. Recently, banks consider adding information regarding borrowers' activities on social media to calculate credit scores. This study aims to examine the relationship between social media accounts' self-disclosure with borrowers' creditworthiness in Islamic Bank. We measure self-disclosure of social media accounts variables as to whether the borrower fills their loan application form with their phone number connected to their social media account, specifically Facebook and WhatsApp. The analysis was carried out on 490 existing customer data at Islamic Bank in Indonesia. The creditworthiness probability model is estimated using a binary logistic regression model. We found that self-disclosure of phone numbers connected to borrowers' social media Facebook has a significant and positive effect on creditworthiness, but this is not the case for the phone number connected to WhatsApp. We recommend that bank management consider this finding to improve their credit scoring calculation


Objective: Assessing the quality of life (cv) and its relationship with reintegration to work, depression and pain in people injured in traffic accidents. Me...


Wound contraction as a result of a delay in grafting or second intention healing in an area that there was no graft take is a serious problem because of the sequela to the burned patient. The objective of the present study was to evaluate the contraction of the cultured keratinocytes and human acellular dermis composite graft by tracing the graft with transparent film after transplantation to the back of athymic mice. The evaluation of the contraction of the composite skin grafts and autografts in relation to the original wound area on the back of the athymic mice demonstrated greater contraction of the grafts after the dressings were removed on the seventh day. The composite skin graft contraction was significantly bigger than the autograft contraction. The experimental data suggested that the contraction appeared after dressing removal, but that the macroscopic aspect of the composite skin graft remained normal with no distortion of the graft or the surrounded murine skin.


December 1978, volume 23 Records at Stanford University were used to explore the relation between changes in the curriculum and financial adversity. Two hypotheses were derived from a model of universities as adaptive organizations with departments competing for resources. To test the hypotheses, changes in eight attributes of the curriculum were studied. The data show that university curriculum responded to changes in financial conditions and that departments of stronger research reputation were less responsive than departments of weaker reputation.


The pharmacy profession, like most others, is growing more sophisticated and complex every year. Practitioners and pharmacy associations are justifiably insisting upon a more active role in the treatment of patients. Indeed, the training and education of the pharmacist places her in a unique position to evaluate drug interactions, side effects, and adverse reactions. Moreover, the introduction and use of computer technology as an aid to the retail phmacist's practice has enabled him, with the execution of a program, to have immediate access to a record of all medications the patient is using. This article looks at two areas of potential liability-side effects of therapy and interactions with other drugs-where it appears that the courts have begun to recognize and assert that there is a legal responsibility corresponding to the pharmacist's evolving professional responsibility. Lastly, the issue of failure to caution of teratogenic propensities, an area where the pharmacist continues to enjoy immunity thro...


Field-structured magnetic particle composites are an important new class of materials that have great potential as both sensors and actuators. These materials are synthesized by suspending magnetic particles in a polymeric resin and subjecting these to magnetic fields while the resin polymerizes. If a simple uniaxial magnetic field is used, the particles will form chains, yielding composites whose magnetic susceptibility is enhanced along a single direction. A biaxial magnetic field, comprised of two orthogonal ac fields, forms particle sheets, yielding composites whose magnetic susceptibility is enhanced along two principal directions. A balanced triaxial magnetic field can be used to enhance the susceptibility in all directions, and biased heterodyned triaxial magnetic fields are especially effective for producing composites with a greatly enhanced susceptibility along a single axis. Magnetostriction is quadratic in the susceptibility, so increasing the composite susceptibility is important to developing actuators that function well at modest fields. To investigate magnetostriction in these field-structured composites we have constructed a sensitive, constant-stress apparatus capable of 1 ppm strain resolution. The sample geometry is designed to minimize demagnetizing field effects. With this apparatus we have demonstrated field-structured composites with nearly 10,000 ppm strain.


Beer-Yacov, Israel In these past years problems of the utmost practical importance have arisen in connection with the use of cortisoneand ACTH for patientswith pulmonary tuberculosis.Among them the followingare outstanding: 1. Does the use of ACTH or cortisonehave a deterioratinginfluenceon an activetuberculousprocessand can itcause a relapse in non-active tuberculous changes? 2. Will a combined treatment, adding antimicrobial drugs to these hormones, prevent unfavorable phenomena as above described? 3. Will the combination of antimicrobialdrugs with ACTH/cortisone influencethe tuberculous process favorably? 4. And if so,are there indicationsfor the use of steroidsin tuberculosis? Which are the suitable doses and what is the average length of time for their use? The firstexperiences with ACTH and cortisonein differentdiseasesand especiallyin rheumatic diseasesproved that not only in activebut even in arrested tuberculosisthe use of these drugs is contraindicated. Many cases have been observed in whom no tuberculosis was found prior to the use of these drugs and in whom severe active tuberculosis appeared after their use. In others a deterioration of inactive processes occurred or new disseminations were found. Supported by these experiences, the American Trudeau Society warned in 1952 against the use of ACTH and cortisonein tuberculous patients. In their opinion, even a non-active tuberculous process is a danger, potentially, for the patient who is treated with these drugs to combat other diseases. In the past two years these views have undergone considerable change. A number of investigatorshave shown that ACTH or cortisone in combination with antimicrobialdrugs not only are devoid of a negative


∗ Text of a paper presented to the Victorian Special Teachers' Association Residential Conference at Hepburn Springs, on 6th July, 1968.


We consider implementation of a deterministic allocation rule using transfers in quasi-linear private values environments. We show that if a multidimensional type space satisfies some ordinal restrictions, then an allocation rule is implementable in such a type space if and only if it satisfies a familiar and simple condition called 2-cycle monotonicity. Our ordinal restrictions cover type spaces which are non-convex, e.g., the single peaked type space and its generalizations. If we exclude indifferences in our types or use a mild continuity condition, then our result holds in a larger class of type spaces. Thus, we uncover an important role of indifferences in such characterizations.


This innovative text provides essential reading for community sector practitioners, academics and advanced level students in public policy, social policy and public administration, as well as for public service professionals.


A fastening device (11) for a spaced apart mounting a carrier profile (1) on a roof substructure (3) comprises a roof hook (12) having a mounting plate (13) and a substantially parallel to the mounting plate (13) arranged fixing portion (14) having a fastening means (21) for the carrier profile (1). The fastening means (21) comprises a fastening screw (22) and a retaining member (26) having a holding portion (27) of the carrier profile (1) and a through-opening (28) for the fixing screw (22).


Abstract The present work gives the results of measurements of the modulus of elasticity and the losses in ebonite by a resonance method. These magnitudes are determined as functions of the temperature for two specimens. At t=19°C, the resonance frequency of one of the specimens was 2784 Hz, of the other 1145 Hz. At these frequencies and higher temperatures ebonite is highly elastic. It is shown that the transition to this state at sound frequencies takes place at a temperature 47° C higher than by the static method.


A method and fuel injector for precision setting of valve lift, using a valve body shell (42) telescoped over the valve body (60), the shell (42) having a nonmagnetic extension welded to the valve body shell (42) and to the end of an inlet tube (16) providing a solenoid pole piece, with the valve body (60) and shell (42) adjusted to set the valve lift and thereafter welded together. Interference fit portions stabilize the adjusted position of the members preparatory to welding, and displaced material in a locking groove (102) creates a mechanical interlock between the valve body (60) and shell (42) to stabilize the members in their adjusted positions after welding so that the set lift is minimally affected by weld shrinkage. An external radial groove 18 allows radial bending as the weld cools to minimize axial shift of the parts and thus the effect on the set valve lift.


In this article we take into consideration the integrative mechanisms of influence on the forming the learners artistic skills. We can differentiate the following aspects stimulation of folk dancing art such as. The spiritual-integral attitude to the achievements of the traditional national culture, the understanding of the symbols, the realization of the emotionally figurative content of the Ukrainian people's myth poetical creation.


Neutron scattering experiments under high pressure revealed the existence of quite novel magnetic structures in CeP at low temperatures. They are characterized by the formation of a lattice of 2μB Ce ferromagnetic layers, inside of which Γ7 Ce layers are sandwiched and orders antiferromagnetically rather independently. The period of the 2μB Ce lattice becomes shorter with increasing pressure, and at the pressures above 1. 7 GPa, the magnetic structures become quite similar to those seen in CeSb at ambient pressure. It indicates that the electronic structure of CeP becomes closer to that of CeSb under high pressure. The present results provide useful information to understand common physics in the typical low-carrier system Ce-monopnictides.


Pre©school education has throughout history, mirrored the changes in the societies it has served. In the 1960's pre©school provision was rediscovered as a mechanism for intervention in the care of minority groups of children who were seen as unable to benefit from of the riches of their culture and society due to inadequate provision in the home or some other external cause such as handicapping conditions within the family. Here assumed cognitive incapacities were to be overcome by the provision of stimulating environments outside of the home. The aim was to resolve inequalities between those who were participants in the creation of wealth, and those who were unable to be. Additionally, attempts were made to equalize educational opportunities, with pre© school programmes instrumental in the early diagnosis of possible developmental disturbances. The most successful of these programmes though, focussed on the advocation of educational objectives and on expert guidance for young children and their parents.(Lazar and Darlington, 1982).


This study aims to determine some heavy metal contents (boron, aluminum, manganese, iron, cobalt, nickel, copper, zinc, cadmium, and lead) of eighteen sunflower seeds obtained from six regions in the Middle Black Sea Region where sunflower is grown. The ICPMS device was used to determine the heavy metal concentrations in the study, and cadmium, and lead amounts in the samples examined at the end of the study were found in the range of 0-0.06 μg kg and 0-1.07 μg kg, respectively. The highest heavy metal concentrations in all the examples were obtained as iron (13.14-61.04 μg kg), zinc (34.11-54.12 μg kg), copper (15.68-20.7 μg kg), and manganese (12.72-20.20 μg kg). These heavy metals were followed by boron (4.82-10.33 μg kg), aluminum (0-13.12 μg kg), and nickel (0.887.74 μg kg). The lowest heavy metal concentration was cobalt (0.037-0.12 μg kg). As a result, the heavy metal concentrations found in the sunflower seeds grown in the Middle Black Sea region were lower than the limit values threading to human health.


CASE SUMMARY 1 A healthy 42–year Old Iranian man who was a butcher presented with a 3 days history of a large bullous lesion on his right thumb. (Figure 1) He had a history of cutting his hand during meat slicing about 10 days ago. On physical examination there was a large 4×5 cm diameter bulla adjacent to a 2×2 cm targetoid nodule. He had no significant past medical history. There was no history of traveling to rural area and no history of any insect bite. The findings of physical examination were unremarkable exc pt for the aforementioned skin lesion. The skin lesion resolved without any scar formation within 3 weeks after its appearance with aspiration of the bulla and topical treatment with an antiseptic solution and zinc oxide ointment. For confirming the diagnosis a skin biopsy was ordered and a histopathologic section of the lesion has been shown in figure 2. What is the diagnosis? (The answer is on page 209)


Evidence for the acceleration of trapped particles by magnetic fluctuations produced by ionospheric currents is derived from the observations of sharp-energy groups of high-energy electrons that, at least on one occasion, appeared suddenly at low L shells (L ∼1.15). An analysis of magnetograms recorded during the onset times of the electrons suggests the action of a quasi-resonance process whereby the electrons were accelerated by fluctuations in the intensity of the equatorial electrojet that had periods comparable to the azimuthal drift periods of the electrons. The energy imparted to the electrons by this process was small but sufficient to cause the electrons, through failure of the third adiabatic invariant, to move to the low L shells from somewhat higher L shells where appropriate fluxes of the electrons were already present. Energy spectra computed on the basis of this acceleration mechanism are in agreement with the measurements. It is also suggested that the variations of the equatorial electrojet intensity were caused by the precipitation of trapped particles in the vicinity of the Brazilian geomagnetic minimum.


Coronary artery bypass gratis (CABG) is the treatment of choice in patients with triple vessel disease (TVD). If the patient has TVD but is asymptomatic, the dilemma is whether to con nue with medical management or to op on for revascularization. CAD prevalence predicts that half of the healthy old males in the United States will grow CAD in the future, while 1 in 3 healthy females will develop CAD. Although the research differs, it is es mated that approximately 26-33 per cent of all CAD patients will experience triple vessel disease. This corresponds to around 1 in 8 males and 1 in 12 females who will grow TVD in their lifetime. In the US, 40.9 million men and 27.2 million women are currently affected by triple vessel disease in their lifetime. Since leti main coronary artery was involved, a person must undergo CABG to prevent sudden cardiac death.


GRAND STRATEGY ANALYSIS: A PROTO-THEORETICAL APPROACH Patrick Magee Old Dominion University, 2005 Director: Dr. Simon Serfaty International relations scholarship begins and ends with assumptions about human nature; about human interaction; about starting points, relative information, and outcomes. Such assumptions are necessary to further the intellectual coherence and development of scholarly work. However, they restrict the applicability of scholarly research to those situations that parallel the work's underlying assumptions. This work argues the body of international relations scholarship as a whole would benefit from the development of a pre-theory state, absent any assumptions about international relations, from which observers can identify those works of scholarship that are most effective in explaining perceptive states and the strategic decisions taken in light of them. Such a state of thinking acts as a proto-theory of international relations. Proto-theory embraces the full realm of international relations scholarship, other fields, and any other area of human thought that provides insight into the manner in which strategic thinkers perceive themselves, their nations, and their situations. By expressing no initial preference for a particular model of decision-making or theory of international relations, it offers a means of transcending debates regarding the "correctness" of any particular view. Rather, proto-theory allows observers to focus on the explanatory power of any particular concept regarding the context under


Amethod which translate a hingeless rotor into a virtual offset flapping rotor and its application in the design criteria of stability and control are presented. The hingeless rotor is assumed to be infinitely stiff in torsional and chordwise bending, and has a flapwise flexibility with nonuniform mass and stiffness distributions. The virtual offset of the flapping hinge and the spring restraint about it are defined with the mass exciting coefficients and the rotating natural frequency, rather than with the Southwell coefficient and non-rotating natural frequency which are presented by YOUNG2) and WARD3). Therefore not only natural flapping term, but also mass excited flapping term of hingeless rotor coincide with those of the virtual offset flapping rotor, and the translating errors of aerodynamic exciting coefficients are decreased fairly in comparison with those of the straight blades of YOUNG, WARD and BRAMWELL4).For the stability and control design of hingeless rot r, the allowable range of blade stiffness factor, virtual offset, Losk number and deltathree angle are presented. These design parameters of hingeless rotor are specified to diminish the variation of control retardation angle with advance ratio and to decrease the gyroscopic cross coupling moment from the standpoint of flying qualities.


This work introduces a novel method that helps in providing an effective way of garbage collection. Due to the difficulties faced in keeping the beach clean manually, we have come up with an equipment which not only collect the waste but also separates, which is easy for waste disposal. The machine mainly consists of a battery and a solar panel which drives the entire process. The waste is collected through the filter by which sand passes through the filter and the waste material is collected and the sand gets out of the filter. It works through Bluetooth and it is also quite easy to run it so that all that work can be done at high efficiency with zero cost investment in fuels.


Despite accumulating evidence for the value of herbal drugs for cancer treatment, the mechanisms underlying their effects have not been fully elucidated in a systematic manner. In this study, we performed a network pharmacological analysis to elucidate the anti-esophageal cancer (EC) properties of the herbal drug FDY003, a mixture of Artemisia capillaris Thunberg (AcT), Cordyceps militaris (Linnaeus) Link (Cm), and Lonicera japonica Thunberg (LjT). FDY003 reduced human EC cell viability and increased the pharmacological effects of chemotherapeutic drugs. There were 15 active pharmacological chemicals targeting 61 EC-associated genes and proteins in FDY003. The FDY003 targets were key regulators of major oncogenic EC-associated signaling pathways, such as phosphoinositide 3-kinase (PI3K)-Akt, hypoxia-inducible factor (HIF)-1, mitogen-activated protein kinase (MAPK), tumor necrosis factor (TNF), p53, Janus kinase (JAK)-signal transducer and activator of transcription (STAT), erythroblastic leukemia viral oncogene homolog (ErbB), nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappa B), and vascular endothelial growth factor (VEGF) cascades. These EC-associated genes, proteins, and pathways targeted by FDY003 determine the malignant behaviors of EC cells, including cell death, survival, division, proliferation, and growth. This network pharmacological analysis provides an integrative view of the mechanisms by which FDY003 contributes to EC treatment.


The research studied the effects of different rumen-protected lysine on rumen volatile fatty acid and bacterium crude protein of dairy cows.Three Holstein cows with permanent rumen and duodenum canula were fed with the diets with different rumen-protected lysine.The result showed that rumen-protected lysine had no significant difference on rumen volatile fatty acid and bacterium crude protein(P0.05).The rumen-protected amino acid had no effect on the rumen environment.


WSC will be meant for the rehabilitation of the blind people. The product is based on the distance measurement property of the ultrasonic sensors. It will measure the distance and velocity of the obstacle in the way of the person and will alarm the person about any obstacle (moving/stationary). There are ~4million blind persons across the world. Many of these persons use products similar to the WSC as travel aid for the blind. WSC will allow detection of obstacles on the ground, holes and pits, uneven surfaces, steps, and other typical obstacles in the path of the person. Apart from other similar products the WSC will also allow detection of potentially dangerous obstacles at head level. Since the device is incorporated with wireless module it will be very handy and will be much easier to use as compared to the similar products available in the market.


The aim of the project "Cows and more" was the development of an expert system with which it is possible, using animal and behavioural criteria, to discover weaknesses in husbandry and management in freestall dairy barns. The digital root-cause analysis is based on a comparison of the individual farm with defined goals and comparison values of a specific data-pool. Moreover, scientific model calculations concerning animals, husbandry and management are used. Through the digital collection of data with a touchpad, technical production advice in the dairy industry will be further optimised. Through the objective and systematic collection of criteria and indicators in relation to behaviour, disposition and metabolism of dairy cows, a standardised root-cause analysis will identify weaknesses. The software will allow the further development of important approaches to optimisation. In the accompanying scientific work criteria and indicators were validated and the system reliability was checked. The assessment of 132 dairy farms with over 10,000 dairy cows resulted in the identification of a number of systematic differences.


Objective: To understand the importance of theater as an occupational therapy resource for the prevention of substance abuse by teens enrolled in a community-based psychosocial project. Methods: A qualitative, descriptive study with a critical reflection approach held at a community center in the Community of Dende, Fortaleza-Ceara, Data were collected from March to May 2009 in a group of ten (10) teenagers of both sexes, aged 12 to 18 years, who lived in socially vulnerable situations and participated in the GESTTO group (Group of Socio-theatrical Expressions in Occupational Therapy). A structured interview was used with a simple observation of groups of theatrical activities and a field book. The analysis of the empirical material was based on Orlandi's discourse analysis. Results: It was found that theatrical activities used as an occupational therapy resource constitute a powerful tool for the prevention of substance abuse, promoting increased self-esteem, the restructuring of the model of social identity, and the discovery of potentialities and abilities by teenagers so that they can become peer educators for the prevention of substance abuse in the community. Conclusion: The theatrical activity provided teenagers with a clear understanding of the use and abuse of illicit drugs, making them more sensitive to prevention and self-identity, making a significant change in their lives.

doi:10.5020/18061230.2013.p333


The Brazilian play, Pagador de Promessas, was first produced in São Paulo on July 29, 1960, by the Teatro Brasileiro de Comedia. Written by Alfredo Dias Gomes, it won three Brazilian prizes during the year: the Premio Nacional de Teatro, the Premio Governador do Estado, and the Premio Melhor Peça Brasileira. In 1962 Anselmo Duarte directed a film version which faithfully adhered to the play. The film was a surprise winner at Cannes that year and gathered laurels at six other festivals, including the grand prize at the Sixth Annual International Film Festival in San Francisco. The film has been shown world wide and the play itself has been produced in several countries, including three short runs in the United States: two in 1964 of an adaptation by Stanley Richards called Journey to Bahia? and the third a production in 1967 of a translation by Oscar Fernández called Payment as Promised* It seems useful to read the play as a kind of modern morality. Ze-do-Burro is the figure of the individual conscience assailed by symbolic representatives of selfish and exploiting men and of purblind institutions. The playwright himself saw the play as the conflict between the man of conscience and the men and institutions which abuse him:


The RELAP5-3D (version 1.5.1) computer program was used to assess a subset of the GE level swell experiments. The primary goal of this new assessment was to provide an updated evaluation of latest fluid flow modeling capability available in RELAP5-3D. In this evaluation great care was taken to faithfully represent the experimental facility and instrumentation. The GE level swell tests were performed using two vessel sizes. The vessels had nominal diameters of 0.3048 m (1 ft) and 1.2192 m (4 ft). This assessment will focus exclusively on four tests, with flow-limiting outlet venturi of different diameters, performed on the larger of the two vessels. The new assessment highlights the sensitivity of choked-flow limited calculations to the value of the input discharge coefficients. Unlike other assessments of choked-flow phenomena, the results of this assessment are essentially insensitive to the particular choked-flow model being employed. However, the use of the optional Henry-Fauske critical flow model is recommended in lieu of the default RELAP5-3D Ransom-Trapp model for consistency with other recent assessments. This evaluation also highlights the effect of time step size on the calculated results. The variation in results obtained using small time steps was unexpected. However, the effect of these variations on the predicted time-dependent blowdown of the system has been shown to be very small. In addition, this assessment has examined a variety of RELAP5-3D interfacial drag correlations. It has been shown that the experimentally-determined void fraction profiles and two-phase mixture levels are best modeled using the optional Vea-Lahey interfacial drag correlation. This paper provides the RELAP5-3D user with guidance as to which correlations to invoke for best-estimate calculations of blowdown transients similar in nature to the GE level swell experiments. Evidence is provided for chosing the interfacial drag model and the critical flow model including its corresponding adjustable coefficients.


Based on the configuration of water turbine draft tube and its flow field distribution features, this paper discusses some manipulation methods in the multi-block grid generation within the draft tube structure . The numerical calculations of 3D turbulent flow within the draft tube are carried out in combination with the research projects of two draft tube type alternation. Accordingly, optimal design is made of the draft tube in this project via the numerical simulation and CFD analysis so that the optimal design results reach the predicted objective.


In general, the policies of operation in mUlti-purposes reservoir systems are established to satisfY all talgets, such as supply water, agriculture, industry and so on. However, this approach does not consider the need for maintain ecology environment. This study focuses on the optimization of operation in a reservoir system with a flow model relating to eco-system built in. Different ratios of demand in agriculture water and that in the ecology in stream flow requirement are analyzed. The results show that more than 3cms of discharge is needed to maintain the quality of habitat in between Shihmen Dam and Y ongfu stream branch. Furthermore, the result is taken into account in the operation optimization model to obtain the rule curves of operation for the reservoir. A set of policies are suggested to the decision-makers. Key word: GA-based optimization, instream flow


The image of the Summer Garden is inseparable from the image of St. Petersburg. It was survived together with the city of the period of formation, rapid flourishing, change of rulers, change, economic sys-tems, natural and military disasters. In June 2009, Russian Museum proceeded to largest restoration on the reconstruction of the memorial ensemble of the Summer garden. The article presents the results of in-spection condition of old-growth trees in Summer and Mikhailovsky Gardens and analyze inventory data from 1962 to 2014, the dynamics of change in the number of trees.


How do people in a position of power address those under their control? Do they impose their own language, possibly in a reduced
 version? Do they adopt a simple form of the language of the people they control? Do they employ a lingua franca that is commonly
 used in the region? Recent research usually focuses on the linguistic strategies the new speakers apply to the input. Much less
 information is available about the input itself. The contributions to the present issue deal with the linguistic strategies and
 policies used by those in power to facilitate communication with those under their control, as well as the modifications they
 apply to their speech. The contributions deal with the input in several work- or trade-related varieties, such as Français
 tirailleur, Garden Herero, Pidgin Madame, Butler English, Lingua da preto, Dienstmaleisch, Kyakhta Pidgin, and the role they
 played in colonial societies.


The existence of the Hertime positive definite solution of matrix equation Xα+A*X-βA=Iis investigated.The matrix equation has a solution Xif and only if Aadmits the following factorization:A=(M*M)β2αN.By the CS decomposition theorem,the new necessary and sufficient conditions for the existence of the solution are obtained.The matrix equation has a solution if and only if there exist unitary matrices Pand Q,and diagonal matrices C0and D≥0with C2+D2=Isuch that A=P*CβαQDP.In this case,X=(P*C2 P)1αis a solution;In the end,using the Brouwer fixed point theorem,if‖A‖≤βα+β+(αα+β),then equation has a solution x∈[βα+β)I,I]


PROBLEM TO BE SOLVED: To measure a shape of an object to be inspected without moving the object to be inspected along an optical axis of an objective lens. SOLUTION: An MLA 12 is disposed on a pupil plane or an image plane of the objective lens 11. An image sensor 13 is installed behind the MLA 12, and captures an image of the object to be inspected by the objective lens 11. An arithmetic processing circuit 34 generates a plurality of measurement images from an output of the image sensor 13, uses correction information of the measurement images as a reference image obtained from pixels at a location for intersecting a main light beam of the objective lens 11 among pixels for composing imaging areas of the image sensor 13 corresponding to a plurality of MLs two-dimensionally arrayed in the MLA 12, and measures the three-dimensional shape of the object to be inspected. The invention can be applied to the shape measuring apparatus for measuring the three-dimensional shape of the object to be inspected. COPYRIGHT: (C)2010,JPO&INPIT


THIS article compares the provisions of the UN Convention on Contracts for the International Sale of Goods (Vienna, 1980--"the UN Sales Convention")' to those of the Uniform Law on the International Sale of Goods (ULIS) and the Uniform Law on the Formation of Contracts of Sale (ULF) (Hague Conventions, 1964).2 The ULIS and the ULF served as the underlying documents for the elaboration of the 1980 UN Sales Convention. Both the ULIS and the ULF did not fulfil the


With the further opening of China's tourism market,there is a dramatical growth in China's demand for ASEAN excellent tourist talents.Teaching of Thai for Tourism Service Course plays a key role in the training program of tourist talents.Through an analysis of the features of Thai for Tourism Service Course,the article presents some suggestions on teaching reform of Thai for Tourism Service Course in Vocational Colleges in Guangxi.


Renin, the rate-limiting enzyme of the renin-angiotensin system, is increased in the kidneys subjected to ureteral obstruction. We elucidated the changes and contribution of renin-producing cells (RPCs) and the cells of renin lineage (CoRL) during kidney damage and regeneration using a partial unilateral ureteral obstruction (pUUO) model in neonatal mice. Renin cells were ablated by cell-specific expression of diphtheria toxin A chain (DTA) and labeled with GFP. We compared the cell fate changes between kidneys from the wild-type (WT) and the DTA-expressing animals, using the pUUO model. The kidneys of 3W old DTA-positive

 Ren1
 dDTA/+
 ;R26R
 DTA/+

 and

 Ren1
 dCre/+
 ;R26R
 DTA/+

 genotypes were grossly normal. We observed no significant differences in the Myh11-positive renal vascular area between the WT and the DTA-positive mice (WT-3W: 1.72±0.10 % (n=6),

 Ren1
 dDTA/+
 ;R26R
 DTA/+

 -3W: 1.94 ±0.123 % (n=7),

 Ren1
 dCre/+
 ;R26R
 DTA/+

 -3W: 2.017±0.16% (n=4)). In the kidneys of the WT group, RPCs and the CoRL significantly increased at 3W post-obstruction and the distribution was similar to the sham-operated kidneys at 2W post-relief of obstruction (Renin-positive area-WT: Sham-3W: 0.57±0.02% (n=6), Obstructed-3W: 1.59±0.44% (n=4), Post-release-2W: 0.71±0.12% (n=3)). There was a significant decrease in RPCs in the DTA animals, and the reduction of RPCs and CoRL was markedly higher in

 Ren1
 dCre/+
 ;R26R
 DTA/+

 mice in comparison to

 Ren1
 dDTA/+
 ;R26R
 DTA/+

 group. Also, the DTA-positive animals did not respond to pUUO with a significant increase in renin as in the WT (Renin-positive area:

 Ren1
 dDTA/+
 ;R26R
 DTA/+

 Sham-3W: 0.13±0.048% (n=5), Obstructed-3W: 0.23±0.10% (n=5), Post-release-2W: 0.14±0.04% (n=9)

 Ren1
 dCre/+
 ;R26R
 DTA/+

 Sham: 0.010±0.004% (n=4), Obstructed: 0.07±0.004% (n=4), Post-release: 0.03±0.004% (n=3)). The renal fibrotic area and
 Tgfb1
 mRNA levels post-obstruction and relief of obstruction were significantly high in

 Ren1
 dCre/+
 ;R26R
 DTA/+

 group in comparison to

 Ren1
 dDTA/+
 ;R26R
 DTA/+

 genotype due to the depletion of CoRL. Thus, our current study reveals that CoRL undergoes cell fate changes in response to obstruction and the release of obstruction, and these changes play a critical role in promoting kidney regeneration post-relief of obstruction.


This work is focused on network traffic monitoring on Linux routers. Measured values of packets and bytes are periodically sent to the central server. They are saved in a database. From that database it is possible to generate graphs of traffic and view it in a web based application.


The invention discloses a preparation method of highly-conductive highly-dispersible graphene powder, and an application of the graphene powder in a lithium ion battery, and belongs to the nano-graphite conductive material field. Graphene oxide is reduced by a reducing agent in the presence of a pyrocatechol-group-containing compound different from the reducing agent. The method has the advantages of low apparatus requirement, mild condition, simplicity, high efficiency and non-toxicity, and is suitable for the large scale production. When the graphene powder prepared in the invention is used to make lithium ion battery electrodes as a conductive agent, good dispersion and internal resistance reduction are realized, and a high-performance lithium ion battery can be obtained.


Recent increased demand in high power density and high-efficiency converters for EV charging makes wide bandgap semiconductors, particularly silicon carbide (SiC), excellent candidates of choice to meet this demand. This paper presents a step-down DC-DC converter using trench SiC MOS made by HITACHI for EV ultra-fast charging. It compares the efficiency and performance of the converter with IGBT and other SiC transistors. In all cases, it shows the clear advantage of the trench etched MOS over alternatives.