An experimental investigation of the dynamic behavior of crack propagation in two birefringent polymers, Homalite-100 and KTE epoxy, is described. Photoelastic isochromatic fringe patterns associated with cracks propagating in center-pin-loaded, eccentric-pin-loaded, and crack-line-loaded single-edged-notched (SEN) specimens were recorded with a high-speed multiple spark camera. Experimental data were obtained in several tests for each polymer to cover cracks propagating from arrest to terminal velocity. The size and shape of the isochromatic fringe loops were used to determine the instantaneous values of the stress intensity function K by matching analytical and experimental results. Analytical results for the fringe loop were obtained by employing a Westergaard stress function of the form Z(z) = K 2π[1 + β'(z/a)] together with a superimposed σ o x = α'√2πa. Approximately 14 000 computer generated fringe loops were compared to the experimentally generated results, and values of the fitting parameters K, α', and β' were obtained. Results obtained for a versus K show an inverted L relationship for both polymers. Crack propagation behavior with respect to the shape of a versus K curve is discussed.


Acute Myocardial Infarction (AMI) is a leading cause of cardiac dysfunction affecting over half a million people worldwide annually. Existing clinical diagnostic and assessment methods could be improved to facilitate early detection and personalized treatment of AMI with the ultimate goal to reduce the associated morbidity and mortality. A 3D personalized LV modelling and thickening assessment framework was developed in this research for assessing regional wall thickening dysfunction and dyssynchrony in AMI patients. A total of 44 subjects consisting of 29 AMI patients and 15 healthy subjects were recruited. Steady-state free precession cine MRI scans were performed for all subjects, and LGE MRI scans were additionally performed for AMI patients. The quantitative spatial thickening measurements across all cardiac phases were computed and correlated against clinical evaluation of infarct transmurality by experienced cardiac radiologist based on AHA 17-segment model and summarized for each individual patient as thickening index (TI) in mm and dyssynchrony index (DI) in % R-R interval. Non-parametric 2-k related sample-based Kruskal-Wallis test was performed to identify significance in thickening and time-to-peak measurements between non-infarcted segments and infarcted segments. Mann-Whitney U test was used to assess TI and DI significance between healthy subjects and AMI patients. The results showed that healthy LV wall segments undergo significant wall thickening (p 50% transmurality) underwent remarkable wall thinning during contraction (TI = 1.46±0.26 mm) as opposed to healthy myocardium (TI = 4.01±1.04 mm). For AMI patients, LV which shows sign of thinning were found to be associated with significantly higher percentage of dyssynchrony as compared to healthy subjects (DI = 15.0 ± 5.0% vs. 7.5±2.0%, p<0.01). Also, strong correlation was found between TI and left ventricular ejection fraction (LVEF) (r=0.892, P<0.01), and moderate correlation between DI and LVEF (r=0.494, P<0.01). The regional wall thickening and dyssynchrony indices extracted from the proposed framework have shown to highly correlate with infarct severity, therefore suggestive of possible practical clinical utility.


Preface Acknowledgments Introduction: Andrea O'Reilly Herrera Section I : The Interior Exile ("insilio") Leandro Soto: Testimonio de un artista Rafael E. Saumell: Oh, La Habana Manena's Cuban American Recipes Hector R. Romero: Life in Exile Sara Rosell: The "Sandwich" Generation Efrain J. Ferrer and Vivian de la Incera: The Thirteenth Suitcase Enrique Patterson: Sin calcetines Julio J. Guerra Molina: Beyond Fear Luis Cruz Azaceta: Dead Rafter II Silvia Curbelo: Balsero Singing Section II: "Merely a Player" Heberto Padilla: Los que se alejan siempre son los ninos Maria Brito: Merely a Player Ileana Fuentes: Portrait of Wendy, At Fifty, With Bra Luz Irene Diaz: The Wooden Suitcase Maria Emilia Castagliola: Once upon a Time in May of 1961... Juan Manuel Alonso: Crossing into the Mainstream Gabriella Ibieta: Fragmented Memories Tony Mendoza: Going Back Section III: Crossing the Generational Divide An Afternoon with Ernesto F. Betancourt Adela Betancourt Jabine: Growing Up Cuban American Maria Antonia Soto: My Life in Exile Francisco Soto: Lost Memories and Nostalgic Obsessions Flora Gonzalez Mandri: Thirty-Two Years Later Rachel Werner Baldwin: Island of Color Alicia Serrano Machiran Granto: Life al reves Gina Granto-Penque: On Being Cuban Ada Manero Alvare: One Mother's Testimonial Tia Ada's Arroz con leche Carlos Alberto Alvare: Losing Eden Section IV: Snapshots Ricardo Pau-Llosa: La hora de los mameyes Maria Cristina Garcia: Abui Olga Mendell: A Cuban American Memoir Virgil Suarez: Song for the Royal Palms of Miami Silvia Curbelo: Photograph of My Parents Silvia Curbelo: First Shift at Hershey's, 4 A.M. Andrea O'Reilly Herrera: Inhabited Woman Nilda Cepero: Burialground Raquel Romeu: A Journal from the Bay of Mariel Jorge Luis Romeu: Political Exile Section V: The Culture Wars Gustavo Perez Firmat: The Facts of Life on the Hyphen Lourdes Gil: Against the Grain:Writing Spanish in the USA Lourdes Gil: From "The Necessary Treasons" Marta Elena Acosta Stone: Understanding del Casal Mayling C. Blanco: A Cubana in NewYork Virgil Suarez: Arroz Carolina Hospital: What Kind of Cuban AreYou? Nilda Cepero: Tropical Flavor Elias Miguel Munoz: Flags and Rags (On Golden Lake) Kenya Carmen Dworkin y Mendez: Next Stop Ninety Miles Section VI: "The Bite of Exile" Jose Kozer: The Bite of Exile Jose Kozer: Autobiography Heberto Padilla: Culture and Exile Ricardo Pau-Llosa: The Wages of Exile Jorge Guitart: Foreigner's Notebook Jorge Guitart: In the Wilderness Connie Lloveras: Living on Borrowed Ground Virgil Suarez: Clotheslines Carlos J. Alvare: Letter to His Niece Emilio M. Mozo: exilio Emilio M. Mozo: sombras Nilda Cepero: Paradox Pablo Medina: Where Are You From? A Cuban Dilemma Pablo Medina: The Chosen Carlota Caulfield: Even Names Have Their Exile Carlota Caulfield: The Photo That Watches Section VII: "Grace under Pressure" Leandro Soto: Cubans in the U.S. Grisel Pujala-Soto: Exile: Reality or lmagination Heberto Padilla: Entre el gato y la casa Raul Fernandez: Musicians in Motion Raul Fernandez: From"Celia Cruz" Raul Fernandez: From"La magia musical de Cachao" Carmen Herrera: Yesterday/Ayer Rafael Soriano: E1 descanso del heroe Rocio Rodriguez: Head and Vessel Luis Cruz Azaceta: From Outside Cuba/Fuera de Cuba Maria Martinez-Canas: Historia rota (Broken History) Orlando Rodriguez Sardinas (Rossardi): Exilio Roberto G. Fernandez: Abode Jesus J. Barquet: Lluvia y primaveras Yara Gonzalez-Montes: Autobiography, Historiography, and Mythography in Matias Montes Huidobro's Desterrados al fuego Section VIII: Inheriting Exile Gisele M. Requena: On Being an American-Born Cuban from Miami Maria de los Angeles Lemus: From "Stories My Mother Never Told Me" Victor Andres Triay: ABCs in South Florida Suburbia Alberto Rey: Appropriated Memories Margarita Engle: Inheriting Exile Cecilia Rodriguez Milanes: Un Testimonio Gabriel Rodriguez: The Grand Finale Maura Barrios: Memoirs of a Tampena Andrea O'Reilly Herrera: Una cubanita pasada por agua Cata's "pie" de guayaba Select Bibliography


This research is in the background by a desire to find the cause saturation of employees working on the CV. ARMINU JAYA ABADI TUBAN. Discussion later in this thesis is a practical description to clarify the concept been there by doing a search data directly in the field either during the Bottled Drinking Water Company (AMDK) CV. ARMINU JAYA ABADI TUBAN, especially with respect to the causes of employee burnout. Type or the type used in this research is descriptive research qualitatively, while data collection techniques used by researchers is the method interview guide based on an interview (interview guidelines), observations and documentation. The subjects of this study are employees of the company's production Water Drinking Bottled (AMDK) CV. ARMINU JAYA ABADI TUBAN. Based on the results of this study obtained results the following conclusion on general, employees at the company's bottled drinking water (drinking water) CV.
ARMINU JAYA ABADI TUBAN experiencing burnout with the job charged to him. This is because the job is monotonous, the burden excessive work, and working conditions that are less supportive. Although in general the CV. ARMINU JAYA ABADI TUBAN experience saturation, but they still tried to enjoy his job, because the search for now very difficult job.


The aim of this article is to establish a classification for the various written documents produced by assistant directors (before and during the rehearsals, during the run-throughs, from the first performance onwards and so on). It also underlines theatrical work as an autonomous subject of interest. These written documents are useful, and even indispensable according to certain directors. The notes may differ in nature at different times in the production process. In their finality they preserve a record of what is to be redone, a record of the work whose existence the audience does not suspect. Contrary to what one might believe, it is not always the actors who retain the truest memory of their work. The following is based partly on my own experience as assistant director, or intern, to Yves Beaunesne, Denis Marleau, Matthias Langhoff and Robert Wilson.


Ternary zirconia-alumina coatings with different compositional ratios, ranging from pure zirconia to 50% alumina content, were deposited by reactive sputtering from two targets, Zr and Al, in argon-oxygen mixtures. The coating composition was controlled by the Zr/Al target power ratio provided by two pulsed-DC power supplies. The coatings were ~1 µm thick and they were deposited on floating potential substrates at a temperature of 650±3K. XRD indicated that the pure zirconia coatings possessed a monoclinic structure with a grain size of 35-40 nm. Adding alumina to the zirconia coating stabilized the cubic zirconia phase and decreased the grain size to 10-15 nm. The alumina phase in the coatings remained amorphous. The hardness of the nanocomposite structure increased from 11.6±0.5 GPa to 16.1±0.5 GPa for an alumina content of 17%. At higher alumina concentrations, the zirconia phase became amorphous and the hardness decreased to 10-11 GPa. Structure stability of the zirconia-alumina coatings was studied by measuring the coating structure and hardness after annealing at temperatures up to 1173 K. Pure zirconia (m-ZrO 2 ) coatings had low structure stability; the hardness reached a maximum value of 18±1 GPa after annealing at a temperature of 773-873K; however, at higher annealing temperatures the hardness decreased, reaching a minimum value of 12.3±0.6 GPa after annealing at 1173K. The hardness of the nanocomposite ZrO 2 /Al 2 O 3 coating with various compositions increased with annealing temperature. The hardness of a coating with an alumina content of 17% reached a high value of 19.2±0.5 GPa after annealing at 1073-1173 K. Measurements of post annealing XRD analyses indicated that the stabilization of the coating structure with c-ZrO 2 /a-Al 2 O 3 phases is the reason for the higher structure stability. From the analyses of phase stability and hardness before and after annealing, we conclude that adding alumina to the zirconia phase promotes the formation of nanocomposite c-ZrO 2 /a-Al 2 O 3 coatings with a markedly higher stability than single-phase m-ZrO 2 . Highlights: 1. ZrO 2 /Al 2 O 3 nanocomposite coatings were deposited by co-sputtering from Zr and Al targets. 2. Adding alumina to the zirconia coating stabilized the cubic zirconia phase. 3. ZrO 2 -17% Al 2 O 3 coatings had a grain size of 10-15 nm and a hardness of 16.1±0.5 GPa. 4. ZrO 2 /Al 2 O 3 coatings maintained a high hardness after annealing at 1173K with a high value of 19 GPa for alumina content of 17%. 5. The ZrO 2 /Al 2 O 3 nanocomposite coatings were crack-free after annealing at 1173K.


For the cost of the current high alarm,high false alarm rate,sending device by environmental and distance constraints,less than the requirements of timely and accurate report to the police,this article puts forward a anti-theft devices installed wireless of alarm,automate the management design and realization of the process,it overcomes the shortcomings of existing technology to provide an automated,timely and accurate report to the police.This equipment is consist of alarm triggered by the client and the receiving end based on the GSM wireless network security.In this paper,it achieves a detailed description from systems,circuit design to implementation.In addition to alarm the device can also automatically send alarm remote client solutions synchronize defense,security,and remote control can be linked to security and control of external equipment.


Rituximab plus cyclophosphamide-containing regimens (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone, intravenously infused every 3 weeks [R-CHOP-21]) had been predominantly used as standard immunochemotherapy for diffuse large B-cell lymphomas (DLBCLs) [1]. However, increased morbidity from hepatitis B virus (HBV)–related adverse events after R-CHOP exposure has raised questions regarding its efficacy and widespread adoption, especially in areas with intermediate and high levels of endemicity for HBV infection [2, 3]. We read with great interest the study by Cheng et al. in the September 2020 issue of The Oncologist [4]. In this retrospective study, 98 patients who were seropositive for hepatitis B surface antigen (HBsAg), receiving R-CHOP-21 as remission induction for DLBCLs, underwent non-homogeneous prophylaxis against HBV reactivation based on the consulting hepatologist's decision. Overall, 28% of these patients developed reactivation or exacerbation of HBV replicationwith hepatic impairment during or following R-CHOP-21, thus experiencing disrupted immunochemotherapy because of HBV morbidity. At a median follow-up of 69 months, progression-free survival (PFS) and overall survival (OS) were 47% and 57%, respectively. The authors underscore that these findings influence decision-making across different frontline therapeutic approaches to DLBCL in such settings because HBsAg positivity is an independent and relevant unfavorable prognostic factor in the rituximab era. There is a need for interventions that mitigate HBV infectious toxicity (especially primary antiviral prophylaxis [PAVP] with a new-generation oral nucleotide analog with a strong antiviral activity and high genetic barrier to resistance) to establish the value of front-line treatment with R-CHOP-21 in patients with DLBCLs and HBsAg positivity [5]. In Blood in 2019 [6], we reported encouraging single-center safety results of a prospective trial in 39 HBsAg-seropositive patients with DLBCLs receiving first-line R-CHOP-21 during the period 2009–2015 at the Hematology Unit of the Federico II University of Naples in southern Italy; these patients' clinical presentations were more aggressive (median age 60 years, advanced-stage disease in 100% of patients, International Prognostic Index scores ≥3 in 75%) than those of the aforementioned study and thus required six cycles of R-CHOP-21 plus two additional courses of rituximab. HBV DNA serum levels were detectable in 31% of cases (median, 499 IU/mL); homogeneous PAVP with tenofovir (245 mg orally daily) was employed in 39 of 39 patients beginning 1 week before immunochemotherapy and scheduled to continue for 12 months after completion. The antiviral prophylactic drug was well tolerated with no discontinuations. After a median follow-up of 78 months, no emergent HBV DNA or exacerbation of HBV replication was registered in any of the 39 patients; in addition none of the patients developed acute hepatitis, and, consequently, no patient experienced chemotherapy disruption for early HBV reactivation and/or HBV-related hepatitis. Finally, 5-year PFS and OS were 76% and 66%, respectively. With the systematic, prompt, and sustained use of PAVP with Tenofovir Disoproxil fumarate (TDF), we were able to drastically bring down the rate of HBV-related toxicity in patients with DLBCLs receiving repeated R-CHOP-21 courses, thus complying fully with the dose density and dose intensity of the immunochemotherapy schedule employed [1]. Guided and encouraged by the evidence of a high level of efficacy provided by the TDF investigators, we launched a prospective multicenter clinical trial in Italy in patients with DLBCLs and HBsAg positivity treated in the front line with R-CHOP-21 and tenofovir alafenamide (EudraCT number 2019000159-14; ClinicalTrials.gov identifier NCT03804372).


A model, compatible with a thermodynamic routine previously described [1], simulates homogeneous nucleation, growth and coarsening of spherical precipitates in aluminum alloys. This kinetic subroutine considers size distribution for each type of precipitate present in the matrix. Local equilibrium is assumed at the matrix-precipitate interface; the corresponding solubility product is corrected by the curvature effect. The equilibrium concentration of each solute element at the matrix-precipitate interface is solved by an iterative method so that the flux of each element is compatible with the solubility product and with the stoichiometry of the considered precipitate. Nucleation and growth of the different precipitates are solved numerically. Coarsening of precipitates is embedded in the equations via the curvature correction of the solubility product. For simple cases, i.e. presence of only one type of precipitate in the microstructure, the coarsening rate can be solved analytically. In that case, the numerical results are the same as the analytical equation results. An example of application will be presented for a binary Al-Li alloy.


In different industrial applications, such as injection molding and/or hot rolling, it is necessary to measure pressure in critical environmental conditions at high temperature. A promising approach for high temperature applications is the use of a wide band gap semiconductor such as silicon carbide (SiC). The excellent electrical and mechanical properties as temperature far beyond 350°C make it a suitable material for electromechanical sensors in high temperature application. The purpose of this work was to investigate the possibility of developing a testing structure to evaluate the longitudinal and transverse guage factors (GFL and GFT) in piezoresistive films in SiC, to evaluate the TCR and finally to define the temperature effect up to 400°C. In the following paper a tailored test structure has been presented together with the preliminary results obtained from piezoeristors realized in SiC technology. The solution proposed assures the most accurate measurement of the parameters of the film without any undesirable influence.


During the submarine cable landing construction, the floating airbag is the key to ensuring that the submarine cable itself is not damaged due to increased stress. Aiming at the existing various types of floating airbags, using the method of numerical simulation, the system optimization research and analysis are carried out from the comparison of the force of different types of floating airbags. It is found that the floating pillow is beneficial to reduce the lateral force of the current on the floating airbags and the submarine cable.


Scleroderris canker (caused by the fungus Gremmeniella abietina) is a disease that causes shoot and tree death of jack and red pine in the Lake States.


This study demonstrates that Tα1 protects mice from anti–CTLA-4–induced colitis and sustains its antitumor activity, thus suggesting that Tα1 may be used in combination protocols. The advent of immune checkpoint inhibitors has represented a major boost in cancer therapy, but safety concerns are increasingly being recognized. Indeed, although beneficial at the tumor site, unlocking a safeguard mechanism of the immune response may trigger autoimmune-like effects at the periphery, thus making the safety of immune checkpoint inhibitors a research priority. Herein, we demonstrate that thymosin α1 (Tα1), an endogenous peptide with immunomodulatory activities, can protect mice from intestinal toxicity in a murine model of immune checkpoint inhibitor–induced colitis. Specifically, Tα1 efficiently prevented immune adverse pathology in the gut by promoting the indoleamine 2,3-dioxygenase (IDO) 1–dependent tolerogenic immune pathway. Notably, Tα1 did not induce IDO1 in the tumor microenvironment, but rather modulated the infiltration of T-cell subsets by inverting the ratio between CD8+ and Treg cells, an effect that may depend on Tα1 ability to regulate the differentiation and chemokine expression profile of DCs. Thus, through distinct mechanisms that are contingent upon the context, Tα1 represents a plausible candidate to improve the safety/efficacy profile of immune checkpoint inhibitors.


A cloud water parameterization under development for the NASA Goddard Institute for Space Studies (GISS) global climate model (GCM) is described. The scheme is based on the studies of Sundqvist (1978) and Sundqvist et al. (1989), with a number of additional features designed to mimic the effects of important microphysical and dynamic processes in clouds. Preliminary results on geographical and seasonal variations from simulations of the current climate are presented.


We examined the immune response in flounder, Paralichthys olivaceus, with immunization of formalin killed Edwardsiella tarda as an antigen. The ELISPOT-assay (enzyme-linked immunospot assay) was optimized technically and applied to count the number of total and specific antibody secreting cells (TASC and SASC) in lymphocytes of different lymphatic organs. Incubation of lymphocytes on 96 well plate for more than 2.5hrs came out enough time in ELISPOT-assay for counting the antibody secreting cells in the anterior kidney and spleen. However, too much of plate-coated antigen or rabbit anti-flounder immunoglobulin for SASC or TASC counting, respectively, was appeared to decrease the sensitivity of the assay system. Specificity of the system was also confirmed by the absence of TASC in lymphocytes treated with cycloheximide to prevent protein synthesis. The peak numbers of SASC appeared at wk 3 post immunization after that there was a sharp decrease and reached to almost zero at wk 7. In the spleen and kidney, the timing and numbers of SASC on peak response were concurrent without preferential organ distribution. The specific antibody level in the sera increased rapidly between wk 2 and 3 after immunization, i.e. like the specific cellular response found with ELISPOT-assay on that period, However, the remained high level of specific serum antibody from wk 5 after immunization until the end of experiment was clearly distinguishable from the kinetics of SASC response decreased sharply.


Efficient syntheses of important metabolites of 7,12-dimethylbenz[ a ]anthracene (DMBA) and benzo[ c ]chrysene (B[ c ]C), via Suzuki coupling reaction are described. This approach provides an excellent method for the preparation of 3-methoxy-DMBA 5 , 10-methoxy-B[ c ]C 14 and 2-methoxy B[ c ]C 20 , and hence for the corresponding dihydrodiols 6 , 15 , and 21 . Following a similar Suzuki reaction, DMBA-6(5 H )-one 8 was also synthesized in high yield.


I present new stylized facts on the market for managers over the twentieth century, utilizing a novel data set on managerial careers. From the 1930s to the mid-1970s, the level of executive pay, in...


Astract−A new denoising method for ultrasonic signal based on blind source separation (BSS) is proposed. To validate the propsed method it is applied to denoising the simulated ultrasonic signals and compared with wavelet denoising method. Experimental results show that the denoising performance of the proposed method is very near to wavelet denoising method. The trait of the proposed denoising method for ultrasonic NDE signals is that noise cancellation is realized by blind source separation of the ultrasonic signal and noise.


An account is given of the more academic aspects of the research work carried out in Germany and elsewhere during the war years, and on this basis a picture of the catalyst and its method of working is developed. The reacting gases reach the catalyst surface directly in atmospheric pressure synthesis, but by solution in and diffusion through the wax that fills the pores of the catalyst in medium pressure synthesis. The cobalt atoms appear to be isolated and do not form part of a cobalt lattice. Reaction by way of chemisorbed carbon atoms-surface carbide-is thought to give an array of inter-acting methylene groups on the surface, and the composition of the products, which are obtained by desorption from this array, depends on the conditions.


SeisSol is a scientific software for the numerical simulation of seismic wave phenomena. However, there are three main problems in the SeisSol project. First, the project documentation is incomplete. Second, the source code comprehensibility is low. Third, the dependencies between the modules in the system are complicated. To solve the problems and to enhance the software quality, we perform a reengineering process on SeisSol. The process contains four steps, reverse engineering, requirements reengineering, redesign and source code refactoring. In the requirements reengineering step, we employ a novel approach to elicit requirements efficiently for such a scientific computing project.
 Through the reengineering process, the documentation of source code, requirements and the improved design is generated, the system is more modularized and easier to be extended, as well as the source code are more comprehensible. e also discuss the lessons learned during the reengineering process.


This report has been researched and compiled for the Burnie City Council and for the
community of Burnie to evaluate the effectiveness of the Dream Big program. Dream Big is
a school-based program based in Burnie, which is situated on the North-West Coast of
Tasmania and is the state's most westerly city (Burnie City Council, 2010). Starting in 2013,
Dream Big aims at improving student engagement and encouraging participation in post
Year 10 education and training, ultimately leading to better school retention rates, a better
overall quality of education, and enhanced employment opportunities within the region. It
is a collaboration between the Burnie City Council, industry partners and education
providers to engage students in conversations about post Year 10 education, training,
business and industry, incorporating site visits for Year 5 students.


August 30, 2023 Encoding UTF-8 Title Selection of Linear Estimators Version 1.1.4 Date 2023-08-30 Author Yannick Baraud, Christophe Giraud, Sylvie Huet Maintainer Benjamin Auder <firstname.lastname@example.com> Description Estimate the mean of a Gaussian vector, by choosing among a large collection of estimators, following the method developed by Y. Baraud, C. Giraud and S. Huet (2014) <doi:10.1214/13AIHP539>. In particular it solves the problem of variable selection by choosing the best predictor among predictors emanating from different methods as lasso, elastic-net, adaptive lasso, pls, randomForest. Moreover, it can be applied for choosing the tuning parameter in a Gauss-lasso procedure. Imports mvtnorm, elasticnet, MASS, randomForest, pls, gtools, stats Depends R (>= 3.5.0) License GPL (>= 3) NeedsCompilation no Repository CRAN Date/Publication 2023-08-30 08:10:02 UTC


Introduction Increased oxidative stress is a hallmark of cancer cells, which makes them more vulnerable to induction of reactive oxygen species (ROS). P53 plays a crucial role in sensing and removing oxidative damage to DNA, and inactivating mutations in the TP53 gene attenuate this function. In addition, it was shown that mutant p53 is able to suppress the function of major antioxidant factors. Therefore, mutant p53 renders cancer cells even more susceptible to the induction of oxidative stress. Besides p53, the poly (ADP-ribose) polymerase 1 (PARP-1) protein plays an important role in the repair of ROS-induced DNA-damage. This led us to explore the potential of combining oxidative stress induction with the targeted inhibition of the PARP-1 protein to selectively target mutant p53 NSCLC cancer cells. Material and methods APR-246 and Auranofin (inhibition glutathione (GSH) and/or thioredoxin reductase 1 (TrxR1)) and Olaparib (PARP-1 inhibitor) were used. The cytotoxicity (SRB-assay) of these compounds was determined in a panel of NSCLC cell lines with different p53 status, including isogenic cell lines (p53 shRNA-knockdown, p53 knock-in). Total GSH content (GSH/GSSG-GloTM) and ROS content (CellROX) were determined. N-acetyl-l-cysteine (NAC) was used as a potent ROS-scavenger. Induction of apoptosis/cell death was determined by the AnnV/PI assay (FC) or the Cytotox Reagent (IncuCyte). DNA-damage was assessed by g-H2AX foci (IF) and the Comet Assay. Synergism was determined using the Additive model. Results and discussions P53Mut knock-down reduces the cytotoxic effect of APR-246, Auranofin and Olaparib, while p53Mut knock-in sensitised cells for all three compounds. APR-246/Olaparib treatment reduced GSH levels and increased ROS content, resulting in a strong accumulation of DNA-damage and synergistic induction of cell death. Co-treatment with NAC or p53-knockdown significantly reduced this cytotoxic response. Similar synergistic effects were observed for Auranofin/Olaparib treatment in several cell lines with clinically relevant p53 mutations. Conclusion Mutant p53 protein expression renders NSCLC cells more susceptible to APR-246, Auranofin and Olaparib treatment. In addition, the combination of oxidative stress induction (APR-246, Auranofin) with PARP-1 inhibition (Olaparib) results in remarkable synergistic effects in the presence of mutant p53. Therefore, this combination strategy could be a promising and selective treatment option for mutant p53 NSCLC patients in which resistance to standard therapies often occurs.


A cyano-bridged copper(II)–copper(I) mixed valence polymer, namely {[Cu4(CN)5(C5H5N)4]}n (1), was synthesized and characterized by elemental analysis, IR spectroscopy, thermogravimetric analysis, differential scanning calorimetric analysis, and single crystal X-ray crystallography. Single crystal X-ray studies show that the coordination polymer 1 is linked by the cyanide anions with μ-1κN:2κC bridging modes to the copper centers, generating a two-dimensional (2D) layered network. The coordination polymer 1, upon pyrolyzing, yielded copper oxide nanoparticles, which have been characterized by TEM and powder X-ray diffraction. The catalytic properties of the resulting copper oxide nanoparticles have also been studied in C–N, C–O, and C–S cross-coupling reactions with aryl halides. The C–N, C–O and C–S coupling products were obtained in moderate to good yields (66–90%, 72–98%, and 50–86%), respectively.


This paper is a study on establishment and transformation of 'Idealistic Urban Design' focusing Project of Creating a Jeonju Hanok-Village. Most project of Urban development begin from idealistic paradigm. But It changes from the early part of the plan and bring about various conflicts. It is same as that of Jeonju. First, Local government of Jeonju established strategy of traditional culture for 'idealistic regeneration of Hanok-Village through tradition.' But It practically concentrated on tourism-commercialization and development of physical facilities of Hanok-village. The Development without adequate discussion and consensus has become the cause of conflicts between local government and local resident. One-side development of Hanok-Village came into conflict with a compensation mentality of local resident that has been violate poverty result from a limit of development for a long time. Jeonju throws a monetary reward or a strong regulation each time. Secondly, It is an commercialization argument of Hanok-Village. The early part of the development, There are many efforts that keep on traditional residential space. But now, in Hanok-village, It can't handle the encroaching commercial capital. Many residential spaces are substituting for tourism-commercial spaces and increasing move of natives.


ABSTRACT How does boundary management (BM) preference influence the effectiveness of work–nonwork policies? Drawing on BM and person–environment fit theory, we examine the effects of off-hours work-related communication restriction on policy satisfaction, organizational commitment, emotional exhaustion, and work engagement. We suggest a moderated mediation model, assuming that the interaction between communication restriction and BM preference predicts perceived BM fit, positively affecting the outcomes. We investigated this assumption using an experimental vignette study (Study 1, N = 257) and a correlational study (Study 2, N = 239). The findings of both studies show moderated indirect effects of the work–nonwork policy on policy satisfaction, organizational commitment, emotional exhaustion, and work engagement (only investigated in Study 2) via perceived BM fit and conditional on BM preference. Specifically, restricting work-related communication only benefits employees preferring low levels of integration. Contrarily, employees who prefer high levels of integration do not benefit from the policy. Due to using two studies with different methodological approaches, these findings rest on data with high internal and external validity. In particular, the experimental method in Study 1 allows for causal inferences on the effects of communication restriction, supporting the literature on BM fit and offering practical implications.


The stability and anchorage control of high and steep slopes in Southwest China are challenging problems in engineering construction. Considering the unloading stability of high and steep rock slopes, field monitoring and numerical analysis methods are used for feedback analysis to study the deformation, stress response, anchorage support scheme, and anchorage stress characteristics during the unloading process of slope excavation. The research shows that the displacement of rock mass of the high slope gradually increases and the local deformation exceeds 200 mm. The unloading relaxation area resulting from slope excavation is 25 m deep. The safety of the slope can be guaranteed after the joint reinforcement of deep anchor cable.


Relaxation labeling networks are a class of parallel distributed computational models extremely popular in computer vision and pattern recognition. Despite their original heuristic derivation, they possess in fact interesting dynamical properties and learning abilities, and exhibit also a certain biological plausibility. In this paper, it is shown how to take advantage of the properties of these models to solve the maximum clique problem, a well-known intractable optimization problem which has practical applications in various fields. The approach is based on a result by Motzkin and Straus which naturally leads to formulate the problem in a manner that is readily mapped onto a relaxation labeling network. Extensive simulations have practically demonstrated the validity of the proposed model.


Background:  the method of translation is a way to translate a text based on the purpose of the text or the message which the writer wants to send to the reader.
Purpose: This paper aims to identify the translation method which commonly use in The Magic of Thinking Big Book by David J Schwartz.
Design and methods: This study uses the descriptive method to analyze this book. The writer finds and get some data and then analyze the data and information by searching internet and library research.
Results: This study revealed six translation method in chapter five of The Magic of Thinking Big by David J Schwartz. Those of translation methods are: Literal Translation, Faithful Translation, Adaptation, Free Translation, Idiomatic Translation and Communicative Translation. However, from six methods which the writer finds, there is the most dominant one which the writer finds in that book. It is Free Translation method.


In this paper a non-linear gain sixth-order boost point of load converter is proposed. It is sixth-order topology, where its gain characteristic is contributed by a non-linear numerator term while denominator preserves the quadratic dependence. To examine the proposed converter performance, a detailed time-domain and steady-state analysis is presented. The L, C components expressions, along with steady-state operating point, are formulated in terms of ripple quantities. The state-space models are derived, for continuous inductor current-mode of operation, and then small-signal analysis is performed to identify the nature of the proposed converter during dynamics. Later on these transfer functions are used in the digital controller design. The proposed circuit is able to boost the load voltage to a higher value than the traditional quadratic boost converter reported in literature. A 48 V, 50 Watt prototype point of load converter with 12 V dc-battery as input is built to supply the power at constant load voltage. The proposed converter features are demonstrated both in simulations and experimentation.


Microparticles (MPs) are intact submicron vesicles released from cells that participate in intercellular communication. Proinflammatory MPs increase the expression of adhesion molecules in target cells. In pulmonary arterial hypertension (PAH), perivascular inflammatory cells are evident around arterial lesions. While we know MPs are increased and inflammation is present in PAH, the link between MPs and inflammatory cell recruitment has not been established. We propose that MPs, generated as a result of PAH, increase the expression of cellular adhesion molecules in pulmonary artery endothelial cells (PAECs). MPs were isolated from the platelet‐free plasma of normal and PAH (Sugen/hypoxia/normoxia) rats at two time points – 3 or 8 weeks. Since Endoglin (CD105) MPs are increased in PAH patients, in select experiments, MPs were sorted by flow cytometry into Endoglin+ and unstained populations prior to treatments. MPs (50 µg/ml of media) were then incubated at 37°C with confluent monolayers of PAECs for 6 hours. Supernatant from activated pulmonary macrophages served as a positive control. Intact and permeabilized PAECs were analyzed by flow cytometry for membrane and whole cell ICAM‐1 expression, respectively. Only MPs from 8‐week PAH rats significantly increased both membrane and whole cell ICAM‐1 expression in PAECs. The Endoglin+ MPs alone from PAH animals significantly increased whole cell ICAM‐1 expression in PAECs. MPs from 8‐week, but not 3‐week, PAH rats increase the expression of ICAM‐1 in PAECs. Further, Endoglin+ MPs from these rats maximally increase whole cell ICAM‐1 expression independent of all other MP populations.


Pipeline transportation is the most important transport mode for crude oil. When oil pipeline operates at low throughput or shutdown, congelation accident always happen as the temperature of oil in pipeline drops, which causes malignant accidents and significant financial losses. Study of the various factors affecting congelation failure is necessary. According to the statistics and analysis of congelation accident, direct and indirect reasons of affecting pipeline congelation failure were determined. Combining with fuzzy comprehensive assessment method, the related importance of factors on congelation accident was studied, and the grade of factors affecting failure congelation of pipeline was also identified. Aiming at the factors, some improvement measures were put forward. These can provide evidences for accident treatment, planned maintenance, security operation and scientific management.


In this paper, we propose a novel location technology-based shopping service system (LSSS); describe its design methodology and implementation detail. LSSS incorporates handheld terminals, resource management system and wireless location technology together to make a whole system. The service provided by the system can make customers in a shopping mall conveniently get product information, notice their current location, figure out proper shopping route when multiple choices are in the shopping list, obtain the navigation information and receive other related innovative services. The successful case experiments proved the feasibility of LSSS in real shopping practice.


Large trades have potentially disruptive effects on the continuation of subsequent trade. If the large trade executes against volume from limit orders or specialist quotations, continued trade may be unavailable until new liquidity enters the market. Evidence presented in this paper indicates that large trades on the NYSE are followed by decreases in quoted liquidity, which last for an average of fifteen minutes. Both the decreases in quoted liquidity and the time to its subsequent return are related to trade‐specific factors. This evidence suggests that not all large trades have the same effect on the continuation of trade.


It is demonstrated that the theories of optical activity given by Born and Post are exactly equivalent, in spite of their totally different physical basis.


This Paper analyses a hold-up problem in the EU enlargement process. EU-specific anticipatory investments of private firms lower the governments outside option. The EU takes advantage of the applicants' increased dependency and extracts more surpluses through entrance conditions that benefit it and impose huge costs on applicants. If private firms pay less than the full entrance fee in taxes, enlargement immiserises the entrant. While in practice an applicant may possess sufficient bargaining power to avoid immiserisation, the hold-up problem reduces its potential gains from joining the EU. This result suggests that previous calculations, ignoring both the applicants' costs of joining the EU and the dynamics of their bargaining position during the negotiations, overestimate the welfare effects of membership.


In order to develop a new type beverage, different methods can be used to extract vegetables. Lettuce leaves, celery, spinach are first immersed in K_2CO_3, NaOH and Zn solution to keep color, and then they can be extracted. Carrot is first immersed in lye to remove its peel, and then steamed with high pressure to be extracted. After the zyme-killing process, lettuce (stem), tomato and wax gourd is extracted; mushrooms are first soaked and then extracted. With the Orthogonal test, the best ingredients of compound vegetable juice are set. After the process of heat operations, cold clarification and flavoring, compound vegetable juice can be made. Without stratification, the product has a green color and a polishing luster. Instead of boiling taste and crude taste, the product has a special vegetable flavor. The vegetable juice content 40%, sugar 5%~10% and no pathogen can be found.


Computer simulations of liquid and solid systems very close to the melting-freezing transition zone have been performed for the microcanonical, canonical, and isothermal-isobaric molecular-dynamics ensembles. Temperature, pressure, and density fluctuations were studied over long evolution times, and graphical and analytical statistical-error methods were used to investigate correlations in the data. The Nose-Hoover (NH) method combined with the Toxvaerd algorithm is proposed as a correct method of obtaining the true fluctuation and correlation of the thermodynamic variables in the system, because the temperature and/or pressure constraints in the NH method do not affect the dynamical evolution of the system, and because the fifth-order Toxvaerd algorithm gives very accurate behavior for the correlations, as has been shown in recent studies


A Research Project Submitted to The School of Business in Partial Fulfilment for The Award of Degree in Masters of Business Administration of Kenyatta University. October, 2018.


This project was undertaken to evaluate the role of the type of road and road width, roadside development, travel speed, driving experience and the sex of the driver on estimates of safety and travel speed. A preliminary study showed that laboratory testing using 16 mm movie film stimulus materials was suitable for testing road speed perception. Three factorial design experiments were performed using urban, rural and semi-rural road scenes in which the independent variables were systematically manipulated. Slash-line responses of safe operation speed and travel speed estimates in km/h were collected from 108 licensed drivers, recruited as subjects. Free speed measurements were also collected at each test site where practical. The results showed that the presentation speed had the strongest effect on the subjects' judgements. The type of road also influenced speed perception while roadside development effects were dependent upon the type of environment (urban or rural) and the road category. Driver experience did not unduly affect the results, although the sex of the driver had a slight influence on the data. Recommendations are made for further research in this area to establish potential countermeasures against speeding.


RATIONALE
A healthy foetus, if exposed to external sound stimulation, often responds with vigorous movements which can be felt by the mother. A hypoxic foetus usually does not show this response.

OBJECTIVES
To evaluate the fetal acoustic stimulation test (FAST) in antepartum fetal monitoring.

DESIGN AND SETTING
Prospective interventional study carried out at the Teaching Hospital, Galle.

METHOD
An initial non-stress test (NST) followed by a FAST using the Corometric model 146 was carried out in 423 high risk pregnant women. The response to FAST was assessed and compared with the NST. A repeat NST was recorded in women who had an initial non-reactive NST. The results of the NST and FAST were compared with the fetal outcome if the woman delivered within 24 hours.

OUTCOME MEASURES
Maternal perception of fetal movements after FAST, results of NST before and after FAST, and the babies' 5 minute Apgar scores if delivered within 24 hours of the FAST.

RESULTS
Of the women, 349 (82.5%) noticed fetal movements after FAST. Of the 167 women who complained of absent or reduced fetal movements, 67% felt fetal movements after FAST. Ninety one had a nonreactive NST and 43 (47%) became reactive after FAST. Compared to the NST, the FAST had less sensitivity (93% vs 100%, p = 0.01), better specificity (79% vs 45%, p = 0.001), better positive predictive value (67% vs 50%, p = 0.02), similar negative predictive values (96% vs 100%, p > 0.05) and better accuracy (83% vs 69%, p = 0.03) in predicting neonatal asphyxia (5 minute Apgar score < 7) if the baby was delivered within 24 hours after the test.

CONCLUSION
The FAST is a reliable, cost effective screening test for antepartum fetal monitoring. It significantly reduces the false positive (non-reactive) NST and has a good negative predictive value.


We &nd ourselves in a paradoxical situation. Early detection of prostate cancer has become di'cult, if not impossible, due to new guidelines against routine PSA screening. Why did the U.S. Preventive Services Task Force, a volunteer panel of medical professionals, rule against wide use of a simple and e(ective screening tool? First, men with suspicious or rising test results are sent for an unpleasant diagnostic procedure (TRUS biopsy) that has been proven to miss up to 30% of cancers. %ose with negative biopsies later have repeat biopsies, while expense (and anxiety) mount up. Second, this protocol &nds too many less aggressive cancers—and the cure may be worse than the disease.


Ticks are important vector arthropods of human and animal pathogens. Information on tick vectors as well as their distribution in Zaria and environs is very scanty. The study was aimed at identifying the various tick species infesting cattle in Zaria using a molecular technique. Ticks were collected from two hundred cattle (n=200) of which 193 (96.5%) were tick infested. The individual ticks were washed, crushed and incubated at 56°C overnight. The extracted DNA of each sample was extracted and amplified targeting the 16S rRNA portion. Ampl icons were sequenced using a capillary sequencer (ABI PRISMR 3130x1 Genetic Analyzer, Applied Biosystems). All sequences were subjected to a Basic Local Alignment Search Tool (BLAST) to determine their identities and assess their homologues and similarities to those in the Gen Bank.


Two alkaloids of indolotryptanthrins, cephathrindole A (1) and B (2), were isolated from Cephalantheropsis gracilis. The structure of cephathrindole A was confirmed by X-ray crystallography whereas cephathrindole B was ascertained by spectroscopic analysis (1D 1 H- and 13 C-NMR as well as 2D COSY, HMQC, HMBC, and NOESY).


Love and hate are very common happen in human life when they have relationship with others. In the literary work of novel, there are the writers who use the theme of their works about love and hate through the characters which they create. This research use Psichology Approachof Love and Hate.The researchers use the theory of triangular of love based on Sternberg's journal and hate theory based on Krech and Dana Harron. Furthermore, this study focuses on Friends With Benefits relationship turns out to be true loveThis research aims to prove that love can come from anywhere, especially having a relationship with benefits and hatred is not always for revenge, because there is hatred we can find out what we like and dislike also not fall into the same thing as is done by Nikole and Carlos. Hatred brings them closer to each other and shares stories. This study uses the method of qualitative research, types of library research, interpretative analysis using the method of data collection in the form of literary texts from the novel The Proposal by Jasmine Guillory as a primary source and supported by some of the literatures to relate the theory, concept and the relevant definition as a secondary source. The result of this research is sometimes we have to get to know someone very deeply even though it hurts to see if love is true or not. I believe that hate doesn't always mean bad. Hate teaches us really khow to love someone right and love also generates hatred based on the character Nik is always in touch with his ex and indirectly compares his ex to Carlos because Nikole doesn't want to fall a second time in the same hole.


To gain insights leading to more effective communication strategies this report reviews past communication policies and activities in family planning/population. There has been a significant change in perception of the role of population and family planning programs since 1973. A more integrated development perspective is adopted. There has been a corresponding change in the design and organization of family planning programs moving from a clinic-based approach to a variety of non-clinic community-based approaches each adapted to unique local conditions. The role of information education and communication (IEC) also appears to be changing from informing people about the availability of contraceptive services to motivating those individuals who have not yet adopted and to maintain the use of family planning methods by couples over the long term. Examples of countries well into this 2nd phase of family planning include the Republic of Korea Colombia Malaysia Costa Rica and China. Regardless of its specific goals IEC has been shown to make a potentially substantial contribution to program success. All national family planning programs in developing countries include an IEC component with an investment from 10% to as high as 35% of the total program budget. A review of past experiences in using a wide variety of IEC strategies by national and international family planning/population programs leads to the following conclusions: in the future it is likely that the use of communication will be more and more directed toward specific audiences in the form of coordinated strategies which involve the use of multiple channels of communication; social marketing and community-based distribution strategies are becoming more important components of national family planning programs; fieldworkers are increasingly paraprofessionals or volunteers who are members of existing community groups; the promising results of present programs which utilize existing local organizations encourages the greater use of local groups traditional channels and institutions; and communication research is changing its role from that of the "KAP-study era" to a new role where research and evaluation will play a greater part in the design and modification of family/planning population programs so as to increase their effectiveness. For a variety of reasons the US Agency for International Development (USAID) Office of Population is at a critical juncture in its organization and supprt of IEC efforts. On the basis of this comprehensive reivew 4 recommendations are made regarding the population activities of USAID itself and 6 recommendations focus on the policies and strategies of population communication which USAID should consider encouraging in the national programs it supports.


The effect of consumer trends on the purchase of reduced fat products in general and fatty spreads in particular are discussed. A variety of fatty spreads with fat levels ranging from 20 to 80% were assessed by cone penetration measurements and sensory assessments. The results indicated that butter had poor spreadability characteristics at 5° and 10°, while mechanically worked butter (spreadeasy butter) gave a significantly different texture profile, as measured by the Instron Model 1000. This butter type was assessed as being spreadable at 10° by the sensory panelists and by cone penetrometry. Comparable values of hardness were obtained using data obtained by cone penetrometry and texture profile analysis from the Instron. Low fat spreads (fat levels 25–39%) produced desirable spreadability characteristics using both objective and subjective methods of assessment. Sunflower oil-based spreads and very low fat spreads, i.e. ≦ 25% fat, were assessed as being soft and oily. The results overall indicated that the use of a cone penetrometer and the subsequent calculation of a yield value gave, using Haighton's seven-point scale, a good indication of spreadability characteristics.


Objective: To study Corneal OCT findings in the interface and the demarcation line under or over the interface in patients that undergo Femtosecond laser in situ Keratomeulisis compared to patients that undergo Femtosecond laser in situ Keratomeulisis combined with high irradiance corneal cross linking (Femto-Lasik Xtra). Study Design: Prospective Randomized Comparative Study. Methods: Our study included 40 eyes of 20 patients divided into 2 groups, a group of 10 patients with 20 eyes underwent Femto-Lasik & the other group of 10 patients of 20 eyes underwent Femto-Lasik Xtra. The Femto Lasik procedure was done using Alcon Wave Light FS200 laser machine. The Femto-Lasik XTRA procedure entails the administration of half fluence high irradiance cross-linking subsequent to refractive correction. A higher concentration 0.25% riboflavin is applied on the stromal bed and the flap subsequent to laser ablation with a soak time of 90 seconds, UV-A irradiance is delivered as a homogenous beam of 30 mW/cm2 for 90 s to deliver a total fluence of 2.7J/cm2. Patients were randomly observed and HEIDELBERG ASOCT was performed after 1 week, 1 month & 3 months post-operative. Results: A demarcation line was noted in femto Lasik Xtra patients, appeared more evident in the peripheral cornea and faded as it approached the central cornea. It became less evident after 1 month and 3 months period respectively. Also the flap hinge was more hyper reflective and evident in femto Lasik Xtra patients when compared to femto Lasik patients. Anterior crosslinked stroma appeared more hyper reflective than posterior stroma in femto Lasik Xtra patients. Flap edge was also more hyper reflective and better demarked in femto Lasik Xtra treated corneas when compared to femto Lasik treated corneas. Conclusion: AS-OCT showed significant differences between femto Lasik and Femto Lasik Xtra treated corneas. Significant changes were noted in the demarcation line in Femto Lasik Xtra patients along different time periods post-operative.


To the Editor: We read with special interest the article by Ven Fong et al published on August 2015. We believe that this study is a cornerstone in pancreatic surgery, bringing a new concept that can greatly contribute to postoperative care in patients undergoing pancreaticoduodenectomy (PD). Surgical resection remains the treatment of choice for patients with periampullary tumors, representing the only chance to obtain long-term survival. Nowadays, with improvements in surgical expertise, anesthesia and postoperative care, this procedure can be accomplished with a mortality rate of less than 5%. Pancreatic fistula (PF), especially that one of clinical relevance, is a major complication after PD, affecting up to one-third of patients. Early prediction of its occurrence is of considerable interest; its exclusion in the early postoperative days enables the treatment of patients under fast-track protocol, which includes mobilization and removal of abdominal drains, rapid evolution of oral feeding, shorter length of hospital stay, and cost savings. This idea is important because the occurrence of PF changes the surveillance of patients, carrying a high percentage of major complications (bleeding, abdominal abscess, need for invasive procedures, or reoperation), often requiring interruption of enteral nutrition, maintenance of drains, use of antibiotics, and close monitoring of 7


The method of analytic regularization in which the number of dimensions is not generalized is shown to preserve the supersymmetry identity relating the anomalies of the supersymmetry current, the trace of the energy–momentum tensor, and the divergence of the axial current at the one-loop level. Explicit counterterms needed for the identity to hold are constructed. The method preserves Dirac and all other tensor algebras in D = 4 space and renders the computation of anomalies straightforward and simple.


Social Media, Web Portals and, in general, information systems offer their own Application Programming Interfaces (APIs), used to provide large data sets concerning every aspect of day-by-day life. APIs usually provide data sets as collections of JSON documents. The heterogeneous structure of JSON documents returned by different APIs constitutes a barrier to effectively query and analyze these data sets. The adoption of NoSQL document stores, such as MongoDB, is useful for gathering these data sets, but does not solve the problem of querying the final heterogeneous repository. The aim of this paper is to provide analysts with a tool, named HammerJDB, that allows for blind querying collections of JSON documents within a NoSQL document database. The idea below is that users may know the application domain but it may be that they are not aware of the real structures of the documents stored in the database—the tool for blind querying tries to bridge the gap, by adopting a query rewriting mechanism. This paper is an evolution of a technique for blind querying Open Data portals and of its implementation within the Hammer framework, presented in some previous work. In this paper, we evolve that approach in order to query a NoSQL document database by evolving the Hammer framework into the HammerJDB framework, which is able to work on MongoDB databases. The effectiveness of the new approach is evaluated on a data set (derived from a real-life one), containing job-vacancy ads collected from European job portals.


Modeling and animating complex volumetric natural phenomena, such as clouds, is a difficult task. Most systems are difficult to use, require adjustment of numerous, complex parameters, and are non-interactive. Therefore, we have developed an intuitive, interactive system to artistically model, animate, and render visually convincing vol-umetric clouds using modern consumer graphics hardware. Our natural, high-level interface models volumetric clouds through the use of qualitative cloud attributes. The animation of the implicit skeletal structures and independent transformation of octaves of noise emulate various environmental conditions. The resulting interactive design, rendering, and animation system produces perceptually convincing volumetric cloud models that can be used in interactive systems or exported for higher quality offline rendering.


The performance of perovskite solar cells is sensitive to detrimental defects, which are prone to accumulate at the interfaces and grain boundaries of bulk perovskite films. Defect passivation at each region will lead to reduced trap density and thus less nonradiative recombination loss. However, it is challenging to passivate defects at both the grain boundaries and the bottom charge transport layer/perovskite interface, mainly due to the solvent incompatibility and complexity in perovskite formation. Here SnO2‐KCl composite electron transport layer (ETL) is utilized in planar perovskite solar cells to simultaneously passivate the defects at the ETL/perovskite interface and the grain boundaries of perovskite film. The K and Cl ions at the ETL/perovskite interface passivate the ETL/perovskite contact. Meanwhile, K ions from the ETL can diffuse through the perovskite film and passivate the grain boundaries. An enhancement of open‐circuit voltage from 1.077 to 1.137 V and a corresponding power conversion efficiency increasing from 20.2% to 22.2% are achieved for the devices using SnO2‐KCl composite ETL. The composite ETL strategy reported herein provides an avenue for defect passivation to further increase the efficiency of perovskite solar cells.


Abstract Adult moths from an ecological group of winter geometrid species look for trees where they copulate and females lay eggs. We investigated how tree trunk and lower branch thickness affects the occurrence of females on trunks and branches and how the density of females and tree trunk thickness affects the occurrence of males on trunks. The research was carried out in a xeric thermophilous oak forest in southern Slovakia (Central Europe) in the winter season 2014–2015. The moths were obtained from Quercus pubescens trees by sticky bands. Three autumn species Operophtera brumata, Erannis defoliaria, Alsophila aceraria and four spring species Agriopis leucophaearia, Agriopis marginaria, Apocheima hispidaria, Phigalia pilosaria were recorded. We have found out that females had not exclusively negative geotactic behaviour as they (except for the rare P. pilosaria) occurred also on lower branches. Tree trunk and lower branch thickness had a positive effect on abundance of females of the three most abundant species (A. leucophaearia, O. brumata, E. defoliaria) on trunks and lower branches. Tree trunk thickness had a positive effect on density of the females of A. leucophaearia on trunks but not on O. brumata and E. defoliaria. The abundance of the males of O. brumata, E. defoliaria and A. leucophaearia on trunks was positively affected by tree trunk thickness and the density of their females.


This chapter outlines how clinical management decisions in humanitarian emergency situations can be greatly enhanced by a well-functioning laboratory. It provides the fundamentals of diagnostic services, including quality assurance and specimen transport, and outlines the basic procedures for the most common tests.


Many software projects seek to shorten the development interval-the time from project inception to final release. To do this effectively, we must understand the mechanisms which increase these intervals, especially in large-scale software production. A significant portion of an individual feature interval seems to consist of the time lost while developers wait for meetings. We have created a simple model which relates the average waiting time to the number of meetings in developers' calendars. Generalizing from this model, we propose a change in the software inspection process. We hope this proposal will lead to further experiments. We present the motivations for our investigation, provide background information relevant to the general goals of our work, and briefly discuss related work. We then describe our model and the results of simulation runs. This is followed by a discussion of the implications with respect to large-scale software development. Finally, we offer our conclusions and suggest some solutions which we believe merit investigation.<<ETX>>


A simple question why cities exist is the main subject in urban economics. Mills (1972) suggested three causes of existence of cities: uneven distribution of natural resources, economies of scale, and economies of agglomeration. Henderson (1974), (1977), Arnott (1979), Kanemoto (1980), and Fujita (1989) analyzed location behavior of firms. They assumed economies of agglomeration in the form of Marshallian externalities. Chipman (1970) constructed a general equilibrium model taking acount of Marshallian externalities which are external to the firm but internal to the industry. Ota and Fujita (1992) developed a general equilibrium model with interactions among firms and households. They analyzed the impacts of telecommunication technologies on the spatial organization of office activities in the city. The question how land should be allocated between residential and transportation uses was analyzed by Mills and de Ferranti (1971). They constructed a model of a monocentric circular city with traffic congestion. Given the CBD boundary, they derived the optimal land assignment for the transportation in the suburbs which minimizes the total social costs. They have shown that there are three optimum patterns for land allocation between transportation and residential uses which are dependent on values of parameters. They have also shown a possibility that all the land is used up for transportation near the CBD boundary. All the three patterns of land allocation to the transportation were also characterized by a concave function of the distance from the city center. However, the CBD boundary in the city was


In the pre-colonial Bekwarra, the administration of justice like most traditional African societies was through established mechanisms generally accepted by rulers, council of elders, age sets, chiefs, and ancestral cults, as well as religious beliefs, and local deities. These institutions adjudicate on a wide range of cases geared towards peaceful co-existence of members. However, the advent of globalization has done little to sustain Bekwarra justice system. Indeed with globalization, social control fashioned after western methods have been adopted in its place. This paper explores and discusses justice and law in pre-colonial Bekwarra and the transformation it has witnessed in an age of globalization.


In applications dealing with the deposition of amorphous hydrogenated carbon layers or in the determination of the composition of deposited layers on the walls of nuclear fusion plasma experiments, the analysis of mixtures of light elements on heavy substrates is necessary. Depth profiling by means of RBS is often difficult due to the overlap of the backscattering intensities of different constituents from different depths. The erosion and reaction of deposited amorphous deuterated carbon (a-C:D) films with a Be substrate due to annealing in air poses an analytical challenge especially if simultaneously the exchange of hydrogen isotopes should be monitored. The analysis of the different recoiling atoms from collisions with heavy ions in Elastic Recoil Detection (ERD) can provide a tool which resolves all constituents in a single analysis. In the present study the composition of intermixed layers on Be containing H, D, Be, C and O has been analyzed using conventional {sup 4}He RBS at 2.2 MeV together with 2.5 MeV {sup 4}He ERD for hydrogen isotope analysis. At these energies, an overlap of signals from different constituents could be avoided in most cases. As alternative method heavy ion ERD using Si{sup 7+} ions extracted from a 5 MeV Tandem Van de Graff accelerator was investigated. At a scattering angle of 30{degree} Si ions could not be scattered into the detector and a solid state detector without protecting foil could be used. Even in the intermixed layers at terminal energies of 5 MeV the heavy constituents could be separated while signals from recoiling hydrogen and deuterium atoms could be resolved on top of the signal from the Be substrate. For the analysis of the RBS and ERD data the newly developed spectra simulation program SIMNRA has been used which includes a large data bank for scattering and nuclear reaction cross sections. The depth profiles of all constituents extracted from the simulation are compared for both methods.


Abstract : The purpose of this MBA Project was to develop a model that would estimate the value of applying available spreadsheet programming tools to automation opportunities in Air Force Financial Management (FM). Model inputs include Labor Estimates, Labor Rates, and Task Characteristics, while outputs are represented in terms of Return on Investment, Payback Period, and Annual Savings. The boundaries of the model are limited to the Microsoft Excel Visual Basic for Applications (VBA) development environment for the development of short-term (<1 year) automation opportunities of low to moderate complexity (Micro Solutions). First, the project model will be outlined and discussed; including the methodology, assumptions, and the specific mapping of input variables to model outputs. Then the model will be used to analyze six actual field-developed case solutions and project potential value for two currently unrealized solutions. Finally, the project will present recommendations drawn from practical application of the model.


The invention discloses a preparation method of a water-based aluminum pigment for external wall heat insulation. The method comprise the steps of feeding raw materials including spherical aluminum powder, a grinding medium, an environment-friendly solvent oil, oleic acid or erucic acid, a passivant, and a titanate coupler into a ball mill; sealing the ball mill, performing ball milling and discharging the raw materials with the environment-friendly solvent oil; conveying the materials into a vibration screen through a pipeline to be screened, removing screen tailings, and putting the materials into a frame filter press to conduct filter pressing, so as to obtain filter cakes with a solid content of 80 percent; and putting the filter cakes, an alcohol or ether solvent with good water miscibility and low molecular weight polyvinyl alcohol together into a reaction kettle, keeping the temperature, discharging the materials, putting the materials into the frame filter press to conduct filter pressing, and performing solid liquid separation so as to obtain a finished product. According to the method, the environment-friendly solvent is adopted to meet national environmental requirements. The aluminum pigment prepared through the method has good water resistance, acid resistance and alkali resistance of the aluminum pigment are achieved, the environmental innocuousness and the service life of the aluminum pigment as a wall insulating coating are improved, and the aluminum pigment is easy to disperse in a paint.


Technical innovation is a must-choice in the successful development of enterprises, and with it, great achievement can be made and other enterprises can be surpassed; technical innovation calls for the spirit of patriotism, and without it, there is no motive to work; enthusiasm in one's career for long is badly needed; attention should be paid to on-the-spot practice, which is fairly important, especially for engineering students. Rational orientation as well as physical and mental health are of vital importance. Diligence, not fearing difficulty and solidarity are the major factors to success.


Objective Method Results Conclusions The COVID-19 pandemic has had a severe impact on mental health. There is an urgent need to deliver low-intensity cognitive behaviour therapy (CBT) tailored to mitigate the impacts of the pandemic. The aim was to engage in a qualitative study of participants' views surrounding anxiety and depression during the pandemic and feedback on the acceptability and usefulness of a low-intensity CBT intervention during the pandemic to inform intervention development and refinement.There were 21 participants (21–80 years, M = 40.90 years, SD = 16.33;71% female) from Australia who participated in qualitative interviews who had completed low-intensity CBT for anxiety and depression during the pandemic.     Themes emerged including the negative impact of the pandemic on mental health, prior experience of psychological therapy, acceptability, and usefulness of the intervention, participants' ideas for intervention improvement, and preferences for using the guide. The majority of participants reported the intervention was useful, however, suggested several areas including content and format to improve the intervention and feedback on what they would prefer for an intervention.A low-intensity CBT intervention was reported as useful and acceptable by participants for their concerns related to the pandemic and exacerbation of pre-existing anxiety and depression. (English) [ FROM AUTHOR] KEY POINTS What is already known about this topic: The COVID-19 pandemic has increased anxiety and depression worldwide. There is a need to deliver low intensity cognitive behaviour therapy (CBT) to mitigate the impacts of the pandemic. Previous research has demonstrated the efficacy of low intensity CBT in reducing pandemic related anxiety and depression. The COVID-19 pandemic has increased anxiety and depression worldwide. There is a need to deliver low intensity cognitive behaviour therapy (CBT) to mitigate the impacts of the pandemic. Previous research has demonstrated the efficacy of low intensity CBT in reducing pandemic related anxiety and depression. What this topic adds: Participants provided positive feedback in qualitative interviews on a low intensity CBT intervention in reducing anxiety and depression related to the pandemic. Participants had several suggestions to improve the intervention, including increasing content for culturally and linguistic diverse populations and alternative formats. Low intensity CBT may hold promise in reducing the burden of anxiety and depression related to the pandemic. Participants provided positive feedback in qualitative interviews on a low intensity CBT intervention in reducing anxiety and depression related to the pandemic.Participants had several suggestions to improve the intervention, including increasing content for culturally and linguistic diverse populations and alternative formats.Low intensity CBT may hold promise in reducing the burden of anxiety and depression related to the pandemic. (Spanish) [ FROM AUTHOR] Copyright of Clinical Psychologist is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full . (Copyright applies to all s.)


Objective To investigate the efficacy and safety of radiofrequency ablation in treating malignant liver tumors. Methods Sixteen patients with total 18 malignant liver tumors including 11 HCC and 7 metastatic tumors were treated with US-guided radiofrequency ablation, 6 were small tumors (≤3 cm) and 12 of large ones(3 cm). Preoperative and post-procedural CT scans were taken in all 16 patients. During follow-up patients underwent enhanced CT in every 2-3 month interval. Results Complete necrosis was obtained in 11 tumors of 18 (68.7%) including 5 small tumors (83.3%) and 6 large ones (50%). Local and intrahepatic recurrences were found in 4 complete necrosis lesions during a mean follow-up of 8.5 months (2-10 month). Tumor's diameter, patients with TAC or TACE history, ablation temperature and size of electrodes showed correlation with necrosis. Conclusion Radiofrequency ablation is effective and reliable in treating malignant liver tumors, and the long-term results are still under investigation.


A theoretical analysis is used to prove that a piezoelectric/magnetostrictive laminate composite has equivalent effective direct and converse magnetoelectric (ME) coefficients. Experimentally a PZT/Terfenol-D/PZT trilayer laminate composite was fabricated and both direct and converse ME coefficients were characterized by measuring the magnetic-field-induced polarization and electric-field-induced magnetization. The laminate sample exhibits similar DC magnetic bias dependence and resonance response for both direct and converse ME effects. The magnitudes of effective ME coefficients are of the same order but significantly different and both are smaller than theoretical prediction. This raises the question as to whether these coefficients are equivalent in a layered composite or to the accuracy of ME coefficient data measurement.


Malcolm Walter was talking about the Pilbara region of Western Australia where some of the oldest known biosignatures of ancient life, in the form of extensive fossilized stromatolites, are preserved. The first potential stromatolite was discovered by graduate student John Dunlop, who was studying barite deposits at the North Pole Dome. Roger Buick went on to investigate the biogenicity of the stromatolites for his PhD (Buick, 1985) and Dunlop, Buick, and Walter published their results (Walter et al., 1980). In a prescient paper, Walter and Des Marais (1993) proposed that the ancient stromatolite fossils could guide the search for life on Mars. I have walked with Malcolm Walter through the Dresser formation where the fossils were found. It is humbling to realize that if time passed at a thousand years per second, it would take 41 days to go back in time to the first signs of life on our planet. In any description of events that occurred some 4 billion years ago, certain assumptions must be made. I will try to make assumptions explicit throughout this book, beginning here with the geochemical and geophysical conditions prevailing on the early Earth and Mars. I am including Mars not as an afterthought but because both planets had liquid water 4 billion years ago. Most of our understanding of planetary evolution comes from observations of our own planet, but it is now clear that the Earth and Mars were undergoing similar geophysical processes during the first billion years of the solar system's existence, with an equal probability that life could begin on either planet. In a sense, the surface of Mars is a geological fossil that has preserved evidence of what was happening there at the same time that life began on the Earth. For instance, Martian volcanoes offer direct, observable evidence that volcanism was occurring nearly 4 billion years ago; making it plausible that similar volcanism was common on Earth even though the evidence has been completely erased by geological and tectonic processes.


Objective To characterize the association between the mean CT value on a scout view and the dependent mA selection method, and to evaluate the clinical value of a mA selection method based on scout view mean CT value in obtaining individualized scan protocol and consistent image quality for patient population on 64-row MSCT CT coronary angiography (CTCA).Methods One hundred patients (group A) underwent CCTA consecutively using standard protocol with a fixed mA.The mean CT value of a fixed ROI (region of interest) from the scout AP view and the CTCA image noise (standard deviation on the root of ascending aorta) were measured.The correlation between CT values and noise was studied establish a formula and a list to determine the required mA for obtaining a consistent CTCA image noise based on the measured SV CT value.Another 100 patients (group B) were scanned using the same parameters as group A except the mA and the CT value was also measured.The mA was determined by the list established previously.The CTCA image quality (IQ) as well as the image noise (IN) and the effective dose (ED) from the two groups were statistically analyzed using t-test.The CT findings for the 32 patients in the group B were also compared with the selective coronary angiography (SCA) results.The sensitivity, specificity, positive predictive value, negative predictive value and diagnostic accuracy of CCTA for detection of significant stenosis were obtained.Results The formula between the required mA and the CT value was : XmA=FmA×[(K1×CTscout + C1)/INa]2.The CCTA images in B group had statistically higher IN (27.66±2.57,22.22±4.17,t=11.33, P=0.000), but no statistical difference between IQ scores for the two groups (3.29±0.66,3.37±0.67,t=0.009, P=0.990), and ED[(8.72±2.51) versus (12.53±0.90) mSv]was 30% lower for the B group (P<0.01).For the 32 patients in the B group who had SCA, the CCTA sensitivity, specificity, positive predictive value, negative predictive value, and stenosis detection accuracy were 94.92% (56/59), 92.13% (82/89) ,88.89% (56/63) ,96.47% (82/85) and 93.24% (138/148) wspectively for stenosis greater than 50%.Conclusion The mA selection method based on the SV CT value for CCTA in 64-row MSCT provides individualized protocol to obtain consistent image quality and to optimize dose delivery to patients.

Key words:
Coronary vessels;  Tomography, X-ray computed;  Radiation dosage;  Quality control


The history of black children's education is marked by restricted opportunities, inequitable funding, segregation, and institutional racism. As a result, black children's academic achievement, consistently and over time, has been less than that of white children. Extensive research has been conducted concerning both the specific sources of black children's lower achievement and appropriate intervention strategies. As a result, we know that black children's achievement is associated with various personal child attributes such as self-esteem, linguistic competence, achievement motivation, and locus of control.1 We also know that black children's achievement is affected by teachers' expectations, perceptions,


PURPOSE: An IPv4(Internet Protocol version 4)/IPv6 communication method and an apparatus therefor are provided so that devices in an IPv6 home network communicate with an IPv4 host by installing a DSPS(Dual Stack Proxy Server) between the IPv6 home network and an IPv4 network. CONSTITUTION: The DSPS has a cache unit(340), a mapping table unit(330) and a protocol control unit(310). The cache unit(340) stores data of a received web page. The mapping table unit(330) maps an IPv4 address and an IPv6 address, and stores the IPv4 address and the IPv6 address. The protocol control unit(310) inquires an IPv4 address corresponding to a web address received from an IPv6 home network to a DNS(Domain Name Server), maps an IPv6 address with the inquired IPv4 address, and connects to an IPv4 host. The protocol control unit(310) receives corresponding web page data from the connected IPv4 host, stores the received web page data in the cache unit(340), and transmits the web page data stored in the cache unit(340) to an IPv6 host with reference to an mapping address of the mapping table unit(330).


Background The utility of the trabecular bone score (TBS) is controversial. Objectives To analyse the clinical usefulness of FRAX-TBS in patients with fragility fracture seen in a Fracture Liaison Service (FLS) compared to FRAX without TBS. Methods Consecutive outpatients >50 y seen in our FLS were included, excluding patients admitted with hip fracture. The variables included were: age, sex, type of fracture, risk factors for FRAX, FRAX for major and hip fractures with and without TBS, bone densitometry (DXA) and indication of treatment to prevent new fractures. Results We included 251 patients, mean age 69 y, 86% women. The most frequent type of fracture was the forearm (n=122) followed by the humerus (n=64). The DXA scan results (taking the lowest value of column/hip) was osteoporosis in 41%. The average TBS was 1.307 (SD 0.103, range 0.961–1.550): forearm fracture 1.313 (SD 0.102), vertebra 1.281 (SD 0.131) and hip 1.291 (SD 0.103). 32% presented normal TBS result 53% partially degraded and 15% degraded (table 1). The results of FRAX with and without TBS were similar, with an average for major/hip fracture of 10.7/4.2 with DXA and 10.6/4.0 with TBS respectively (p>0.05). A high risk of hip fracture (FRAX ≥3) was observed in 43% of patients using FRAX-DXA and 41% using FRAX-TBS. Ans a high risk of major fracture (FRAX ≥10) in 40% of patients using FRAX-DXA and 41% using FRAX-TBS. In 241 cases (96%) there was concordance in level of risk for FRAX-DXA and FRAX-TBS, while the 10 discordant cases for high risk of fracture were distributed as follows: in 6 cases FRAX-DXA was high and FRAX-TBS was normal, and in 4 cases FRAX-DXA was normal and FRAX-TBS was elevated. In our FLS, a bisphosphonate was prescribed to 169 patients (67%). Regarding patients with a low FRAX risk (n=82), in one patient FRAX-TBS was in favour of treatment. Thus, in 1/251 fractures FRAX-TBS could have influenced the treatment indication compared to FRA-DXA. TBS≥1.350Normal TBS<1.350 y≥1.200partially degraded TBS<1.200Degraded Number of patients 80 134 37 Age, mean (SD) 67 (11) 70 (10) 71 (10) Sex, women, n (%) 65 (81) 124 (92) 33 (92) Risk factors, n (%) BMI, mean 27 29 31 Previous fracture 8 (10) 34 (25) 7 (19) Parent's hip fracture 8 (10) 21(16 2 (5) Glucocorticoids 6 (8) 5 (4) 5 (13) Smoking 9 (11) 20 (15) 6 (16) Alcohol 2 (3) 4 (3) 1 (3) Rheumatoid arthritis 3 (4) 2 (1) 0 Secondary osteoporosis 13 (16) 22 (18) 10 (28) Bone Densitometry, n (%) Normal 24 (30) 7 (5) 3 (8) Osteopenia 37 (46) 65 (49) 12 (32) Osteoporosis 19 (24) 62 (46) 22 (60) Conclusions In our FLS unit, TBS does not help to classify patients' risk. The values of FRAX-TBS are similar to those of FRAX-DXA, not offering advantages when classifying patients with high risk who are candidates for treatment. Disclosure of Interest None declared


The innovative activity of entrepreneurial structures in Russia does not meet the requirements of the modern level of scientific and technological progress. One of the reasons for this appearance is an unfavorable economic climate, characterized by the underdevelopment of the institutional and infrastructure environment, market conditions and business conditions, the need for knowledge and technology from the business community, and the creativity of the pre-resiners. At the same time, for modern domestic entrepreneurship, the characters are weak with the main contingent of its stakeholders, which is why the consideration of the requirements and capabilities of the main part of potential partners is difficult. The proposed al-city development of the strategy and tactics of innovation in entrepreneurship will eliminate identified flaws. The subject is the socio-economic processes and relations that arise in the process of managing innovation in entrepreneurial activity. The direction of the study is the definition and methodological justification of the approach to the development of an innovation management policy in entrepreneurial activity in the context of an unfavorable innovative climate based on a stakeholder approach. The purpose of the study is to justify the influence of the innovative climate and accounting for the interests of the main stakeholders on innovative activity and innovative policy of entrepreneurial structures. Development of an algorithm for the formation of an innovative strategy and tactics of the company. In the process of research, general scientific (analysis and synthesis, induction and deduction, analogy, generalization) and special (monographic, statistical-economic, abstract-logical) methods of scientific knowledge were used. Based on the analysis of the innovative climate formed in the conditions of the formation of Industry 4.0, the need to take into account its key parameters in the development of strategy and tactics for managing innovation in entrepreneurial activity is substantiated. The influence of relationships with internal and external stakeholders on the activity and success of innovative processes in business structures has been clarified. The algorithm for developing a strategy and tactics for managing innovations in entrepreneurship has been developed and substantiated. Promising mechanisms for the activation of innovative activity in internal development are substantiated. The results of the study can be used by the legislative and executive state authorities, the academic community in the development of areas of improving the innovative climate, as well as business entities for the development and development of internal policy of innovation management.


Monascus-nata complex was made up from fermented nata which was grown in the medium containing Monascus purpureus fungi, that could be used as coloration of nata. Rice flour usually used as medium to produce pigments by M. purpureus. Tofu solid waste and rice bran could be used to produce pigments although the colour intensity of M. purpureus pigment was lower than rice. The aims of these research were to study colour, pH medium and weight of miselium Monascus-nata complex from the combination of rice flour with tofu solid waste extracts and rice flour with rice bran extracts as the medium. In these research, 5% (b/v) rice flour extracts, combination of rice flour extract : tofu solid waste extract in the ratio of 1:1, 1:2, 1:3 and rice flour : rice bran extracts in the ratio of 1:1, 1:2, 1:3 were used as the medium. Ten nata de coco (1x1x1 cm3) were put in to the extracts of medium (100mL) in bottle, then inoculated with 10% (v/v) starter of M. purpureus containing 1.3x107 cfu/mL and incubated at room temperature on an orbital shaker at 100 rpm for 16 days. Parameters which were measured, i.e. colour intensity, preferable test, pH medium, weight of miselium Monascus-nata complex. Data were analyzed using analysis of variant and followed by DMRT in 5% significations except preferable test which were analyzed using hedonic test. Combination of rice flour extract : tofu solid waste extracts in the ratio of 1:1 could be used to replace rice flour extracts on the making of Monascus-nata complex. Orange colour intensity from rice flour extract : tofu solid waste extracts in the ratio of 1:1 was higher than from rice flour extracts. Orange colour intensity from rice flour extract : tofu solid waste extracts in the ratio of 1:1 and rice flour were 0.156 and 0.123 respectively. Red colour intensity from medium rice flour extract : tofu solid waste extracts in the ratio of 1:1 approach the red colour intensity of rice flour. Red colour intensity from medium rice flour extract : tofu solid waste extracts in the ratio of 1:1 and rice flour extract were 0.088 and 0.145 respectively. All of pH value decreased from 7 to 6.82. Weight of miselium Monascus-nata complex from all medium was average 0.024 g. © 2005 Jurusan Biologi FMIPA UNS SurakartaKey words: Monascus-nata complex, rice flour, tofu solid waste, rice bran


The (well-known) quantum mechanical expression for the stress tensor is derived and applied to obtain a formula for the pressure in the average-atom model. This average-atom pressure formula reduces to the (well-known) expression for the pressure in a classical free-electron gas when the average-atom continuum wave functions are replaced by free-electron wave functions. 1 Derivation We start with the time-dependent Schrödinger equation for an electron in a potential V (r), − h̄ i ∂ψ ∂t = − h̄ 2 2m ∇2ψ + V ψ (1) The expectation value of i-th component of the electron's momentum inside a region R is 〈pi〉 = ∫ R dτ ψ†piψ. (2) The rate of increase of momentum in R is d dt 〈pi〉 = ∫ R dτ [ ∂ψ† ∂t piψ + ψ†pi ∂ψ ∂t ] = − ih̄ 2m ∫ R dτ [ ∇2ψ†piψ − ψ†pi∇2ψ ] − i h̄ ∫ R dτ ψ† [piV − V pi]ψ. (3)


Objective To study the clinical factors influencing prognosis of breast cancer. Metheds 100 patients of postoperate breast cancer were followed-up for 71.34 months. The data were processed with survival analysis,and multivariate analysis was done with Cox proportional hazard model. Results Lymph node,tumor site,tumor size,TNM clinilal stage, tumor recurrence and expressions of ER and PR were significant factors influencing the prognosis. There was marked difference in 5-year survival rate among the factors,and P values were respectively 0.0012,0.0031,0.0032,0,0,0.0014 and 0.0041. The outcome of Cox model proportional hazard regression indicated Lymph node, TNM clinilal stage,tumor recurrence and expressions of ER were independent prognostic factors. Conclusion Early diagnosis,early operation and endocrine treatment were key factors in improving the prognosis, assessing clinical stage and early finding metastases and recurrence.


We propose an all-optical analog-to-digital converter that can extract a binary word from a multilevel optical signal during a single bit interval. This optical circuit is constructed using optical limiters whose transmitted power clamps to a fixed maximum level for inputs exceeding a chosen threshold.


Objective To investigate the effect of application of hierarchical management in clinical nursing management. Methods Fifty nursing staff were selected in our hospital from September 2011 to September 2012, used a hierarchical model of management, the control group with the same collection was not implemented in 50 nursing staff management for compared. Results The nursing management and satisfaction in the observation group were superior to the control group (P 0.05). Conclusion The hierarchical management can ensure the quality of nursing in clinical nursing management.


By neutron diffraction measurements of B-DNA duplex, we have succeeded in determining the D positions in 27 D2O molecules. Moreover, the complex water network in the minor groove has been observed in detail. By a combined structural analysis using X-ray and neutron data, it is clear that the spine of hydration is built up, not only by a simple hexagonal hydration pattern, but also by many other water bridges hydrogen-bonded to the DNA strands. The complexity of the hydration pattern in the minor groove is derived from an extraordinary variety of orientations displayed by the water molecules.


We conduct a framed field experiment in Mindoro, Philippines on ecological altruism. Behavioral differences between ethnic groups in Mindoro, the Tagalogs and the Mangyans, were investigated. We design a two-part donation task (i.e. dictator game) where the recipient of the donation is a local reforestation project. There were two treatments: They played either the giving game (GG) or the taking game (TG). In the first part, in GG, respondents were asked how much they will donate towards reforestation, while respondents in TG were asked how much money they will take away from the project and keep for themselves. The second part was the same as the first; but participants were asked what they will do if a hypothetical partner, who was either the same or different ethnicity as theirs, donated half of the initial endowment to reforestation. Results indicate that Mangyans, who are predominantly farmers, tend to give more in the TG than the GG. Tagalog respondents were not sensitive to framing. Finally, other-ethnicity dynamics did not have a strong effect.


MF-$0.83 HC-$6.01 Plus Postage. Academic Achievement; Academic Aspiration; Community Colleges; *Cooperative Educaticn; Employer Attitudes; Employment; Followup Studies; Income; *Junior Colleges; *Occupational Surveys; Participant Satisfaction; Relevance (Education); Technical Education; *Vocational Education; Work Experience The objective of this study was tc appraise:Macomb County Community C011egels (MCCC)_industrial_cooperative education program. Students enrolled in_design and mechanical technology from 1970 to 1975# who either participated in' the co-op program (N=252) or did not (N=274), and their employers (N=45) responded to the questionnaires. Information was gathered in the folloWing areas:. current job status; salary; method of obtaining employment; work experience previous to college training; reasons for attending MCCC; education since leaving ,MCCC; four-year college attended; rating of the educational program and of the_cooperative education experience; and suggestions and comments. Results showed that 65% of the co-op respondents were employed in program-related full-time jobs. The co-op group was more likely to use ;college services when seeking employment. Only 3.57% of the co-op group was unemployed as compared to 6.5% of the non co-op group. Sixty-seven percent of the co-op group graduated from MCCC as compared to 39% of the non co-op group. Ncin co-op group. respondents reported earning higher salaries; The employers wht responded indicated a favorable rating'of the employees trained_atMCCC and they perceived those with co-cp. experience as more efficient and able. to -learn more quickly. Respondent comments, the survey instruments, and a-bibliography are appended. (MB) * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * Reproductions suppliedby EDRS are the test that can be made from the original document. *********************************************************************** Pt iif Pft()DiJI:E THIS I t OAS HFEN Cii,:.NrE I) By Edward Breen THi E DUCA I(1NAL RES011itCES 01-0.1%.11()N CENTS It ANI'? (CF Till. E.Int: MACOMB COUNTY COMMUNITY COLLEGE DEPARTMENT OF RESEARCH AN APPRAISAL OF THE INDUSTRIAL COOPERATIVE EDUCATION PROGRAM U S loi TH. ET" J FL 1E -IONAL INS'"LUTE. t C'vTION THIS DOCUA ET. HAS BEEN C2 :PRODUCED EXA RECEP/FD_F kOrt THE PERSON On rtFTGANIZATION ATING IT PO VIEVV OR ()PIN, t; STATED DO N IECESSAREL-Y-REPRESE_NOFFICIA OTI INSTITSJTE OF EDUCATION PAS C OR POLICY BASED ON RESPONSES FROM STUDENTS AND EMPLOYERS Prepared by: Edward F. Breen Nancy S. Freeman October 144_1977 ,Project #0184-76 Second Printing November 14; 1978