A method for optimizing an active control system which will suppress flutter and minimize the response of a lifting surface to atmospheric turbulence is presented. A mathematical search method is developed which will find a control law which will cause an active control system to flutter at a specified freestream velocity, air density, and Mach number. With the flutter velocity of the system held constant, the control law is then modified in such a way that the peak output power spectral density function of the angular response of a lifting surface (as a result of atmospheric turbulence) is minimized for a specified flight velocity which is less than the flutter velocity. The von Karman generalized power spectrum for the transverse components of turbulence is used in an example problem to increase the flutter velocity and minimize the turbulence response of a simplified delta-wing model which has leading and trailing edge control surfaces.


Using the minimal extension of the standard model and considering the charge radius and the anapole moments of a neutrino, we derive analytical expressions for the stellar energy loss rates associated with the production of a neutrino pair in hot plasma under three limiting regimes (nondegenerate, intermediate, and degenerate electrons) of the temperature, electron chemical potential, and plasma energy. The obtained results reveal the presence of an extra contribution of approximately % based on the considered calculations.


I read with interest the recent article by Mentsoudis et al regarding the risk/benefits of midazolam preoperatively in a total joint arthroplasty population. They reported no association of midazolam with delirium, a significantly decreased incidence of cardiac and pulmonary complications and an increased incidence of falls. In a previously published review using the same Premier Healthcare Database examining the same total joint population as the current article, the authors determined that patients receiving shortacting benzodiazepines had significantly lower risks of postoperative delirium. The lesser incidences of delirium may have been because of neuroprotection accorded by midazolam during periods of vascular embolization incurred by arthroplasty surgery. Indeed, cerebral protective effects from midazolam have been previously reported by Michenfelder and others. 4 In the current database analysis, the authors confirm that there is no increased risk of delirium from midazolam (and cite collateral investigations thus the long held view that midazolam results in increased incidences of delirium may be unfounded. Of interest in an article cited by some members of the ASA regarding inappropriate medication use in older adults, it is stated "all benzodiazepines increase risk of delirium"; however, midazolam is not mentioned in this article and no citations are listed to substantiate this statement. In the current article, the authors also determined a significantly decreased risk of pulmonary and cardiac complications in patients who received midazolam which leads to speculation of additive cardiac and pulmonary protective effects in this subset of patients. The possible association of increased falls is difficult to understand particularly with the knowledge of decreased delirium associated with midazolam administration and rapid dissolution of midazolam effect if only given preoperatively. The authors also determined that gabapentinoids when combined with midazolam increased sedationrelated complications which would be expected when adding any sedative agent. I concur with the authors that indiscriminate use of any drug, including midazolam, should be discouraged; however, the documented benefits of decreased delirium, and lesser pulmonary and cardiac complications in a total joint population should not preclude its use in this population of patients when indicated.


Along with our country marketability degree inceasing enhancement,our region economy development had the considerable progress.But in the region economy development incisively exposes some contradictions day by day,division between local and department's is still serious.So"the administrative area economy""the feudal lord economy"becomes the disturbance macroscopic economy movement the biggest barrier.Therefore,how enable the economic zone to obtain the full development,realizes the region economy entire and the perfect condition,is the vital realistic question which we are urgent to solve.


The purpose of this study was to develop the compositions and technology of corundum armored ceramics with high ballistic characteristics based on aluminum oxide with an α-Al2O3 content of more than 99 wt.%. The results of the study of the physicochemical processes of obtaining corundum ceramics modified with complex additives consisting of magnesium - aluminosilicate eutectic mixture and oxides of magnesium, yttrium, titanium, zirconium are presented. The introduction of complex additives into the composition of corundum ceramics provides a significant reduction (100-150°C) of the sintering temperature of the product. In this case, additives of yttrium and zirconium oxides contribute to the formation of a uniform-grained microstructure of ceramics, and in the case of adding titanium oxide, a collective recrystallization of corundum grains is noted. The use of small additives (0.3-0.5 wt.%) of magnesium and yttrium oxides together with a eutectic mixture in the compositions of corundum ceramics based on high-quality alumina contributes to the formation of a uniform-grained, dense structure of the material and giving it a high level of physical and mechanical properties as a result of directional the action of each component of the additive on the physicochemical processes of phase formation of the crystalline matrix. A model idea of the mechanism of action of additives on the formation of the microstructure of ceramics during stage-by-stage heating from 1350 to 1650°C in the sintering mode of products is presented. The developed compositions and technologies of corundum armored ceramics have a production focus and implementation in practice.


The priming experimental paradigm sheds light on different aspects of memory processes and has several applications. Priming is an implicit memory effect, in which there is no conscious retrieval information recently experienced. In Brazil, very few studies using this methodology comparing to the international literature is observed. Aiming to encourage studies to use this paradigm, the goal of this paper is to present and discuss methodological aspects relevant to the elaboration of repetition priming 1 Endereço para correspondência: Universidade Federal do Rio Grande do Sul, Instituto de Psicologia, Avenida Ipiranga, 2600, sala 114, Porto Alegre, RS, Brasil 90035-003. E-mail: firstname.lastname@example.com Sbicigo, J. B., Janczura, G. A., Salles, J. F. 1534 experiments emphasizing the selection of materials (software, standardized stimuli lists for Brazil and the relevance of psycholinguistic factors) and the manipulation of variables (instructions and exposure time of the stimuli, for example). The conclusion was that: a) PsycoPy is an excellent free software access option, while E-prime is an excellent option to license requirement; b) priming stimuli tests must have Brazilian norms, considering psycholinguistic aspects and norms for property pictorial stimuli; c) short Stimulus Onset Asynchrony – SOA (less than 300 ms) associated with the mask are excellent to investigate automatic and not conscious priming activations; and d) techniques to reduce the explicit infl uence should be used as the Retrieval Intentionality Criterion. Finally, recommendations for future research are presented.


The urban water resources system is a dynamic system, consisting of climate and water source condition, water supply and drainage works capacity, city property, population, living and technical level, economic strength and industrial structure of city. Thereby, the evaluation of urban water resources includes not only the water resources itself such as water quality and quantity but also the utilization, allocation, supervision and management level; in other words, not only the evaluation of the natural resources but the whole social and economic system as well. The concept of social renewability of urban resources and its assessment indexes was put forward, and ANN-based assessment model of social renewability, a new assessment model of urban water resources, was established in order to consider the social cycle of urban water resources adequately, reveal the exploitation and utilization potential of water resources in the cities, and understand the importance of social renewability of water resources in city water resources assessment. The other characteristic of the model is the construction of the evaluation standard. The maximum and minimum of the assessment indices of the cities in whole country was assembled separately forming two extreme "virtual cities" of highest and lowest grade (5 and 0). One virtual city had the maximum of indices and the other has the minimum. Then the distance between the maximum and minimum was decided, and a range of virtual cities as the training samples of BP networks independent upon experience of the appraisers was constructed. In this way, the assessing problem was transformed to a classification problem which ANN was adept in. And the assessment result was more directly perceived through the sense and easy to understand.Furthermore, the model was applied to analyze and assess the main cities in the Yellow River basin, and was compared with the traditional method: Gray-Relation Method. The results of assessment were fit with the practical situation.


Cruise specific fuel consumption (SFC) of turbofan engines is a key metric for increasing airline profitability and for reducing CO2 emissions. Although increasing design bypass ratio (BPR) of separate exhaust turbofan configurations improves cruise SFC, further improvements can be obtained with control actuated variable geometry modulations of core nozzle throat area, bypass nozzle throat area, and compressor variable vanes (CVV). The scope of this paper is to show only the benefits possible, and the process used in determining those benefits, and not to suggest any particular control algorithm for searching the best combination of the control effectors. A parametric cycle study indicated that the effector modulations could increase the cruise BPR, core efficiency, transmission efficiency, propulsive efficiency, and ideal velocity ratio resulting in a cruise SFC improvement of as much as 2.6% depending upon the engine configuration. The changes in these metrics with control effector variations will be presented. Modulation of CVV is already possible in legacy digital controls, and modulation of nozzle areas should be explored in light of the low bandwidth requirements at steady-state cruise conditions.Copyright © 2016 by ASME


Effects of different doses of vitamin C against acetaminophen (APAP)-induced hepatorenal toxicity was investigated in male rats. The experimental groups included, a control group which received vehicle, a group intraperitoneally injected with a single dose of vitamin C (320 mg/kg body weight (b.wt.)), a group which received an oral overdose of APAP (1 g / kg b.wt.), as well as three groups administered the APAP overdose followed by a single dose of vitamin C (80, 160 or 320 mg/kg b.wt). All animals were watched for 24 hours, after which the mortality rate and serum levels of the hepatorenal indices were measured. Liver glutathione level and the ultrastructure of hepatic and renal tissues were also studied. Administration of APAP overdose induced a high mortality rate and hepatorenal toxicity as indicated by significantly higher levels of hepatorenal indices and decreased liver glutathione. It also caused cellular alterations and necrosis of hepatocytes and some renal cortical cells. However, injection of vitamin C alone caused no abnormalities. The injection of vitamin C after APAP administration decreased the hepatorenal toxicity in a dose-dependent manner. The highest dose of vitamin C normalized the levels of liver glutathione and serum hepatorenal indices except for bilirubin. It also protected hepatic and renal cells except for slight dilatation of rough endoplasmic reticulum and glycogen depletion in some hepatocytes, as well as the presence of lysosomal structures in cortical tubular epithelia. No fatalities were seen in rats treated with the highest two doses of vitamin C. It could be concluded that the highest dose of vitamin C prevented against the lethal effect of APAP overdose, although it incompletely protected against hepatorenal toxicity.


RESEARCH on the basic qualities, characteristics, and needs of individuals and groups as related to counseling and guidance which has appeared during the three-year period of this review is summarized in this chapter. Over 300 bibliographical items were examined. It is hoped that the resultant bibliography is a representative sample. To conserve space many items listed are not discussed in the text; the bibliography is composed almost exclusively of reports with new data. In some cases an entire series of excellent papers is represented only by a recent number. Examples of the latter are the series on handedness by Hildreth (37) and the case analyses by Wells (97) .


A clan named Chao living in Zhaodefang in Song dynasty is one famous family in the Central Plains in ancient China.In the early years of Nan Song Dynasty,they moved to Sichuan and Chongqing,actively involved in cultural reconstruction and cultural creation.They made important contribution to construct the culture of the Three Gorges.


In Namibia in 1990, apartheid was ended, and a democratic form of government was installed; 2 years later, the national government established a system of partially decentralized regional governments. At the same time, the government reacted to the severe drought of 1992 by instituting a national drought relief bureaucracy with particular attention to the predominantly Black African communal areas, which incorporated the new regional councils. This, in turn, created the opportunity for those councils to serve as organizational nodes within widening policy and informational networks related to the drought relief process. These networks incorporated village leaders, ministry officials, and the regional councillors and helped to assure the effective implementation of the drought relief program. This suggests a strong (although not determining) link between informational networks and policy outcomes. This article also makes clear that provided sufficient behavioral responsibility, subnational governmental bodies can play crucial roles in drought relief processes in developing-world settings.


To investigate the effect of anodic oxidation process parameters on TiO2 nanotube formation in Ti6Al-4V alloys, the composition of NH4F and H2O in the anodic oxidation processes were changed under the conditions of constant DC power ranging from 20 V to 60V and current density ranging from 10 mA to 30 mA. As the amount of NH4F was increased, the surface reaction rate became faster and surface dissolution also became more active. This result can be explained by the fact that TiO2 nanotubes were basically formed in the TiO2 layer located in the front of the Ti matrix by selective dissolution of the oxide layer, due to F ions existing in the electrolytes. In anodic oxidation in ethylene glycol + 0.2 wt% NH4F with different amounts of water ranging from 0 ~ 8 vol%, the increase in the amount of water resulted in an increase in both the diameter and the length of growing nanotubes. When the voltage increased, the diameter and the length of the nanotubes tended to increase. But no nanotubes were formed at the voltage and the current density lower than a certain critical value. An increase in electrolytic holding time resulted in the diameter of the nanotubes increasing and decreasing repeatedly, but eventually increasing. X-ray analysis indicated that the as-grown nanotubes were amorphous while the anatase phase and the rutile phase were detected after anodic oxidation treatment, followed by annealing at 650 C under Ar atmosphere for 2 hours. (Received February 14, 2019; Accepted June 13, 2019)


Terrestrial vegetation has been known as a main source of biogenic volatile organic compounds (BVOCs). Isoprene and monoterpene among the BVOCs are most abundant species emitted by forests, and have a significant impact on atmospheric chemistry. Abundancy of these species could lead to an increase or decrease in the production of natural tropospheric ozone in forests, depending on the nitric oxide (NO) concentration. Soil is the most significant source of natural NO. Understanding of NO emission from forest soil could be critical in evaluation of air quality in the forest area. Flux-gradient similarity theory (FGST) was applied for practical use to estimate forest soil NO emission at Mt. Taewha where is available micro-meteorological data near surface monitoring from flux tower. NO fluxes calculated by FGST were compared to flux results by flow-through dynamic chamber (FDC) measurement. Surface NO emission trends were shown between two different techniques, however their magnitudes were found to be different. NO emissions measured from FDC technique were relatively higher than those from theoretical results. Daily mean NO emissions resulted from FGST during Aug. 13, 14 and 15 were 0.28±8.45, 2.17±15.55, and -3.18± 13.65 ?gm-2 hr-1, respectively, while results from FDC were 2.26±1.44, 5.11±3.85, and 2.23±6.45 ?gm-2 hr-1. Trends of daily means were shown in similar pattern, which NO emissions were increasing during late afternoon (r2=0.04). These emission trends could be because soil temperature and moisture influence importantly soil microbiology.


4-(2,5-Dibromoimidazolyl)-2′-aminopyridyl form complex with Na 2 PdCl 4 in methanol. 1 mmol% of the complex was utilized in Suzuki-Miyaura cross coupling reaction to prepare substituted biphenyls and terphenyls in good to excellent yields. DOI: http://dx.doi.org/10.3329/jbcs.v25i1.11779 Journal of Bangladesh Chemical Society, Vol. 25(1), 87-96, 2012


This paper describes the design and testing of a wireless sensor network based on the SmartBrick, a low-power SHM device developed by the authors. The SmartBrick serves as the base station for the network, which utilizes additional sensor nodes to periodically evaluate the condition of the structure. Each node measures vibration, tilt, humidity, and strain, and is designed for easy interfacing of virtually any other analog or digital sensor. The sensor nodes use Zigbee to transmit their data to the base station, which in turn uses the GSM cellular phone network to provide long-range communication and support for remote control. The system has been designed from the outset to minimize power consumption, and is projected to operate autonomously for up to four years without any on-site maintenance, due largely to the minimal power consumption and rugged design. Remote calibration over the GSM network further increases the autonomy of the system. Most importantly, it can perform all requisite actions with no cables for power or communication. The focus of this paper is the addition of short-range wireless communication over Zigbee. This allows a network of several devices to be used to monitor larger structures, such as multi-span bridges. Results of laboratory testing are included and discussed in detail, demonstrating the unique capabilities of the proposed SHM system.


We study the topological properties of 3D Floquet bandstructures, which are defined using unitary evolution matrices rather than Hamiltonians. Previously, 2D bandstructures of this sort have been shown to exhibit anomalous topological behaviors, such as topologically-nontrivial zero-Chern-number phases. We show that the bandstructure of a 3D network model can exhibit Weyl phases, which feature "Fermi arc" surface states like those found in Weyl semimetals. Tuning the network's coupling parameters can induce transitions between Weyl phases and various topologically distinct gapped phases. We identify a connection between the topology of the gapped phases and the topology of Weyl point trajectories in k-space. The model is feasible to realize in custom electromagnetic networks, where the Weyl point trajectories can be probed by scattering parameter measurements.


Shear horizontal (SH) guided waves are commonly used in non-destructive evaluation and can be generated by permanent magnet electromagnetic acoustic transducers (PPM EMATs). PPM EMATs generate SH waves that propagate either forwards and backwards. This is often an undesired characteristic. Recently, we presented designs of PPM-like EMATs that generate SH waves in a single direction through the interference mechanism of two independent periodic sources of forces. In this paper, we present a line-source based analytical model to calculate the radiation pattern produced by multi-PPM EMATs and, in particular, by dual-PPM EMATs, which are able to generate SH waves in a single direction. The model was validated by computing the radiation pattern of a unidirectional side-shifted dual-PPM EMAT, showing good agreement with experimental and numerical results.


Holocene sediments are a key control on the groundwater hydrology and spring-fed stream flow in the lower Wairau Plain, New Zealand (Figure 1), as demonstrated by three-dimensional models of lithology and static groundwater level measured in wells and a groundwater budget. These models have provided significant new information about the lower Wairau Plain groundwater and suface water system, including the association of lithology with groundwater gradients in three dimensions and the controls on locations and flows in spring-fed streams. In the west, Holocene Rapaura Formation gravel, deposited in a terrestrial environment, is common at the ground surface (Figure 1). Static groundwater levels (SGLs) typically decrease with depth indicating a vertically downwards component of groundwater flow. The transition zone includes spring-fed streams (i.e., Spring Creek and Blenheim urban streams), Figure 1. Holocene Dillons Point Formation sediments (typically sands, silts and clays) deposited in a marine/estuarine environment and Rapaura Formation gravels crop out in this area. Groundwater inflow to the transition zone is approximately 8.2 m/s, of which 8.1 m/s flows in the Rapaura Formation aquifer. Most groundwater outflow from the transition zone (7.1 m/s) is to the spring-fed streams, consistent with SGL gradients that are typically vertically upwards through Dillons Point Formation sediments in the area. In the east, Holocene Dillons Point Formation sediments thicken towards the coast. Vertical SGL gradients are typically upwards indicating groundwater flow into the Rapaura Formation from the underlying Pleistocene formation. In addition, a web-based interactive portal that provides instant access to information on groundwater systems and geology in three dimensions will be demonstrated.


Word embeddings such as ELMo and BERT have been shown to model word usage in language with greater efficacy through contextualized learning on large-scale language corpora, resulting in significant performance improvement across many natural language processing tasks. In this work we integrate acoustic information into contextualized lexical embeddings through the addition of a parallel stream to the bidirectional language model. This multimodal language model is trained on spoken language data that includes both text and audio modalities. We show that embeddings extracted from this model integrate paralinguistic cues into word meanings and can provide vital affective information by applying these multimodal embeddings to the task of speaker emotion recognition.


Multiple-Input Multiple-Output (MIMO)wireless (MMSE)equalization isrigorously derived in(6), whilean systems offer multiplexing gainanddiversity gain. Whileitis approximate BERexpression ofMIMO withzero-forcing (ZF) knownthatthediversity order ofMIMO transmissions withequalization isderived in(7).However, these analysis are Nttransmit andNrreceive antennas overi.i.d. Rayleigh fading . d channels isNr- Nt+ 1athighsignal-to-noise ratio (SNR),heavily dependent onthespecific channel probability density thesameconclusion cannot ingeneral bedrawnforbit-error function (pdf). Theyrequire integration overagiven channel rate(BER)gainforallSNRandother channels. We show pdf, without whichnoconclusion canbemade. a BER performance ordering fordifferent transmit antenna Inthis paper, wedevelop anovel approach toanalyze the sizes inMIMO wireless systems withpractical zero-forcing (ZF)error-rate performance inMIMO system withZFequalization equalization, whichholdforallSNR.We provethatwhenthe thatisnotlimited totheSNR extremes butapplyforall numberofreceive antennas isfixed, theaverage BERimproves withadecrease inthenumber oftransmit antennas, which showsrangeofSNR.Inparticular, we focusontheimpact of thetradeoff between BERandbandwidth efficiency inMIMO transmit antenna size ontheBERperformance. Assuggested withZFequalization. fromthediversity order athighSNR,decreasing thenumber oftransmit antennas should enhance theBER performance,


Purpose: We aimed to apply Ultrasound Liver Imaging Reporting and Data System (US LI-RADS) to the patients with positive serological HCV test surveyed during the national mass screening campaign. Methods: We conducted a cross-sectional study that recruited patients with positive serological test for HCV, who underwent the national mass screening campaign during the period from April 2019 to June 2020. Each operator was required to classify the patients into one of the following three categories according to the US visualization into: A, no or minimal limitations; (2) B, moderate limitations; and (3) C, severe limitations. Results: A total of 763 HCV patients were recruited in the present study. Conclusion: US is the modality of choice during mass screening for HCC, yet the presence of the human factor (being operator dependent) and the lack of unified reporting scheme were drawbacks; thus US- LI-RADS, overcome the latter drawback with ready to go plan according to the given score of each individual patient.


This paper investigates the relationship between interest rates and government budget deficits in Pakistan over the period from 1970: I to 1991: IV. The results reveal that government budget deficits do not exert significant influence on nominal or real interest rates. These findings do not lend support to the « Crowding-Out » hypothesis winch suggests an inverse relationship between government budget deficits and rate of interest.


Among benign tumours, ovarian cysts can develop during the foetal period, but generally regress during the neonatal period. Nevertheless, they can be detectable by ultrasound (US) and clinically palpable owing to their size and/or pedicle torsion. Functional ovarian cysts and precocious puberty are frequent in McCune-Albright syndrome which is genetically based on somatic mutations in the GNAS1 gene coding for the G-protein Gsa subunit. These are activating mutations where, in the absence of luteinising hormone (LH), G protein complex is activated, cAMP production increased, and LH regulated genes are activated. Although GNAS1 mutations appear in both sexes, with polyostotic osseous fibrodysplasia and cutaneous cafe-au-lait spots, precocious puberty development by Gsa complex activation in gonads is more frequent in the female gonad. Other functional ovarian tumours causing pseudoprecocious puberty and producing oestrogens are granulosa and theca cell tumours. Although the majority are unilateral and benign, without recurrences, their association with intestinal polyposis and mucocutaneous pigmentation in PeutzJeghers syndrome have a familial genetic base.


Following the lead of Canadian counterparts and working with representatives from a number of agencies involved in Aotearoa New Zealand's counter-terrorism efforts, the Combined Threat Assessment Group (CTAG) led the development of a uniquely New Zealand framework intended to be a specific, objective and accurate representation of the threat from all forms of violent extremism relevant to New Zealand. This was a deliberate effort to seek a set of accurate terms that avoided unduly securitising legitimate, non-violent political, ethnic and religious communities and beliefs, while simultaneously not adding unwarranted legitimacy to violent extremist ideologies. This article outlines and explains the Violent Extremism Ideological Framework increasingly in use across security sector agencies – and is written by those whose created it.


The authors study main characteristics of certification of section of railways located in adverse engineering and geological conditions and put forward a system of assessment of reliability and risk level indices for track structures, and propose a classification scheme for imperfections and deformations of the subgrade.


Summary For the prediction of the lithofacies cube, it is proposed to use new age full-functional Kolmogorov neural networks. These three-layer neural networks, which can be positioned as a new generation of neural networks, have a high degree of freedom comparable to deep multi-layer neural networks. For a more accurate lithofacies cube, it is suggested to perform the forecast in two stages. At the first stage, a separate forecast of each lithofacie is made in the form of a probability cube. At the second stage, the connection of such cubes into one lithofacies cube is based on the principle of maximum probability.


Human being is by nature an occupational individual, and seeks during lifetime the harmony between his activity and the surrounding environment. The elderly is no stranger to this feeling, so it is suggested that people who are active, will have a better aging, will be satisfied with their lives and will be better adapted to their social environment. The objective of this research was to establish the importance of leisure time in old age, and the regulation about the subject, which identifies Tourism as an option for occupation. Different concepts of Leisure Time, Old age and Tourism are also marked, besides the implications of tourism for active aging person. This research is documentary, and its development is a review of the past 20 years on the theoretical, conceptual and normative references. This information was aimed to analyze the relationship between tourism and the elderly under the Occupation - Person Context model (Baum, Bass- Haugen and Christiansen 2005). The results show a wide regulation that supports tourism, it can be conceived as an occupation and analyzed from an own model for Occupational Therapy. Therefore, tourism is understood as an alternative activity of leisure time for the elderly.


This study reports our preliminary experience of percutaneous coronary angioplasty with low dose heparin and immediate withdrawal of the femoral sheath. After selection, 120 patients underwent a procedure with a low dose of heparin (4,300 ± 700 IU). A total of 120 of 123 lesions (97.6%) were treated successfully by the femoral route. There were no major cardiac complications during the procedure and hospital stay. Patients were allowed to be ambulant 6 hours after the procedure. No significant bleeding occurred. There was no need for surgery relative to the approach route nor for blood transfusion. The use of low dose heparin and immediate withdrawal of the femoral sheath did not increase the risk of coronary angioplasty in these selected patients. The period of bed confinement was shortened and the patients were ambulant earlier, leading to a reduction in their hospital stay with no increase in costs.


Purpose
The purpose of this paper is to examine stability and change in the linkage between gender and managerial stereotypes over a five-decade period.

Design/methodology/approach
Samples from two populations (n = 2347) described a "good manager" on an instrument that assessed masculinity and femininity during each of the past five decades.

Findings
Good-manager descriptions exhibited a decreasing emphasis on masculinity and increasing emphasis on femininity over time, culminating in an androgynous profile, or a balance of masculine and feminine traits, for each population in the most recently collected data.

Practical implications
Although women face systemic barriers in the managerial ranks of organizations, a change in managerial stereotypes to an androgynous rather than masculine profile would represent one less barrier for them to overcome.

Social implications
If managers come to be held to an androgynous standard in their behavior regardless of their gender, there would be a more level playing field for candidates for open managerial positions, rather than one tilted in favor of men.

Originality/value
The analysis of data from samples of the same population types using the same measures systematically over five decades, and the provocative finding of an androgynous profile of a good manager in the most recently collected data, are original contributions to the literature.


Inappropriate expression of genes such as the homeotic (HOX) genes is found in up to 40% of cases of Acute Myelogenous Leukemia (AML). Two well-defined genetic subsets, those with MLL-rearrangements and those with NPM1 mutations, are known to possess high-level expression of HOX and MEIS1 genes and have been shown to be dependent on continued expression of these genes. Recent studies have defined the chromatin-bound protein complexes that maintain this aberrant gene expression. Furthermore, multiple groups including ours have now developed small molecule inhibitors of chromatin-associated complexes. Some of these small molecules, including those targeting DOT1L, EZH2, and Bromodomains are at various stages of clinical development. Another approach to target chromatin associated complexes is via disruption of protein-protein interactions. One such protein-protein interaction that is being targeted is the interaction between the histone methyltransferase MLL1 and Menin, an approach that has also been shown to reverse leukemogenic HOX/MEIS1 gene expression. We have developed novel, potent and orally bioavailable MLL1-Menin inhibitors and have brought one of these small molecules to clinical assessment. Inhibition of the MLL1-Menin interaction in MLL-rearranged and NPM1 mutant AML cells leads to loss of Menin from chromatin, destabilization of the Menin protein and specific changes in chromatin state that include loss of the MLL1 complex at select loci. This results in selective reversal of leukemogenic gene expression, changes in occupancy of multiple other chromatin complexes, rapid cellular differentiation and cell death. Also, we have recently found this interaction to be critical in subtypes of Sarcoma opening up novel potential therapeutic opportunities. These molecules have remarkable preclinical activity in human disease models including patient derived xenograft (PDX) models, show minimal toxicity and are now in phase I/II clinical trials. Inhibition of protein-protein interactions represents a potentially effective approach to destabilize chromatin associated complexes for cancer therapy.
 Citation Format: Scott A. Armstrong. Therapeutic targeting of MLL complexes in cancer. [abstract]. In: Proceedings of the AACR Special Conference: Cancer Epigenomics; 2022 Oct 6-8; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2022;82(23 Suppl_2):Abstract nr IA020.


SUMMARY An experimental investigation is described into the effects of acoustic disturbances on the mean flow in a turbulent boundary layer developing in a mildly favourable pressure gradient. A Hartmann generator, mounted on the centre line of the RAE 8ft x 8ft wind tunnel, was used as a noise source, and the mean flow in the boundary layer on the tunnel sidewall was examined for any effects of the noise. Even at noise levels up to C~ = 0.08 it was not possible to P identify any effect of the noise itself on the boundary layer, and it is concluded that the acoustic disturbances generally found in the working sections of tran-sonic wind tunnels are unlikely to exert a measurable influence on the development of turbulent boundary layers on wind-tunnel models-at least for mild pressure gradients.


Disclosed are a method and device for transmitting a short message. The method comprises: an SMS-GMSC receiving a short message to be transmitted and a first user identifier of a target user of the short message sent by an SMSC; the SMS-GMSC requesting, from a home server and according to the first user identifier, a plurality of user identifiers of the target user and routing information respectively corresponding to the plurality of user identifiers, wherein the plurality of user identifiers are inter-related; the SMS-GMSC receiving the plurality of user identifiers and the routing information respectively corresponding to the plurality of user identifiers sent by the home server; and the SMS-GMSC sending the short message to a terminal device corresponding to at least one user identifier from among the plurality of user identifiers. According to the method in the embodiments of the present invention, a short-message single-point failure can be avoided without changing an existing protocol, and a short message can be effectively transmitted where there are a plurality of terminal devices at the same time.


A new soft-switching control scheme for zero voltage transition (ZVT) inverter using coupled inductors is proposed in the paper. By applying this new control scheme, the ZVT inverter has several salient features: simple fixed timing control for the auxiliary switches does not require any load information, thus eliminates the needs of current for soft-switching operation; all the main and auxiliary switches are under soft-switching condition; the auxiliary circuit current level is adaptive to the load current, thereby minimizing the conduction loss. The operating principle and design procedures are presented in the paper. Simulation results verify the validity of the proposed scheme.


In the context of global warming, the mountainous areas of Central Asia are sensitive to climate and environmental changes and are highly vulnerable to natural disasters. Here, we use high‐resolution lacustrine grain‐size and geochemical records from Lake Issyk‐Kul to infer hydrological changes, environmental events, and their driving factors in the western Tianshan Mountains of Central Asia over the last 350 years. The regional hydrological and environmental changes can be divided into three phases. In stage I (1674–1860 AD), the values of total organic carbon (TOC), total nitrogen (TN) and magnetic susceptibility (MS) were high, and the element contents changed indistinctively, suggesting that lake water levels were relatively stable. In Stage II (1860–2000 AD), the TOC and TN contents increased, the MS values decreased, and the grain size changed markedly, suggesting that water levels fluctuated dramatically. In Stage III (2000–2013 AD), the coarse particle and migratory element contents increased dramatically, indicating that regional rainfall and runoff increased and that the water level rose. Studies have also shown that the synchronous increases in sedimentary coarse particles, TOC and migratory elements indicate multiple flood events. Extreme floods have been frequent and intense in recent years, which indicates that the climate is generally warming, which is in good agreement with tree ring data, ice core records and other sediment records in alpine regions. Additionally, the lake sediments recorded a seismic event in approximately 1910 AD, which was consistent with historical documentation. Comparative analysis of records suggests that the Atlantic Multidecadal Oscillation is one of the dominant factors driving climate and hydrological changes in the study area. Climate change, combined with natural disasters (e.g., earthquakes) and anthropogenic activities, is generating extreme floods and variations in hydrological patterns in the mountain basin. These findings can provide crucial information about sedimentary physicochemical clues for tracking past hydrological and environmental conditions and contribute to a better understanding of hydrological processes and driving factors in the mountainous areas of Central Asia.


Early recognition of dementia syndrome can result in earlier intervention, thus earlier prevention and better management of dementia. However, there is a difficulty with instruments to screen for dementia in developing country. Low education, illiteracy and innumeracy of the ageing population may be screened positive for dementia. The Rowland Universal Dementia Screening Assessment Scale (RUDAS) was developed for cognitive function measurement for multi-cultural population with strong reliability and validity and had been validated in countries across the world. However, the literatures had reported no dementia screening studies with the use of the RUDAS in the Indonesian community. This study was the first study to screen for dementia utilising the Rowland Universal Dementia Assessment in the Indonesian community, which was undertaken in 2016 in Bencongan Indah, a subdistrict of a city in Banten. This was a descriptive study to screen for dementia using the RUDAS in the Indonesian community. Data was collected using purposive sampling with inclusion criteria: adults age 60 and over, Indonesian-speaking participants, there was no apparent acute illness that could affect the performance of the test. The validity and reliability of the RUDAS were assessed prior to the main study on 35 participants who had similar characteristics with the study respondents. The Indonesian version of the RUDAS instrument was assessed for validity and reliability prior to the main study. This study showed that out of 60 elderly respondents of 60-74 years old in the study, half (50%) had mild to moderate cognitive impairment, as scored 22-26 on the RUDAS. However, the study lacked investigation of demographic factors affecting the RUDAS performance. Recommendations Further study validating the use of the Indonesian version of the RUDAS is warranted.


T-HE PROBLEM of determining the constitutional limits of retroactive leglislation has always been approached with the implicit assumption that "retroactivity" is a distinct legal phenomenon with its own, almost unique, set of constitutional difficulties.' The thesis of this Article is that questions of retroactive law are essentially questions of substantive due process, and that any attempt to treat retroactivity as a special category to which special rules are to be applied is wasted effort. In the first section the meanings of retroactivity are discussed. The second will examine some decisions of the Supreme Court, in order tor discover the basic factors usually involved in determining the constitutionality of those laws commonly regarded as retroactive. These factors will then be used to explain and justify a few patterns that have emerged from the Court's long involvement with this sort of legislation. The last two sections, necessarily brief because based more on speculation than on examination of judicial experience, will deal with two rather special types of retroactive law.


Abstract The Gothenburg Magnetic Excursion ended with a fully reversed "Flip" in the Fjaras Stadial dated at 12,350–12,400 B.P. The Bredakra delta in south-eastern Sweden was formed during a climatic deterioration lasting for about 85 years. Palaeomagnetic measurements of three varved clay sequences are reported. A sequence covering the time of the formation of the Bredakra delta possesses negative polarity (for 199 varves), correlatable with the Gothenburg Magnetic Excursion/Flip. Varves just pre-dating the delta formation show normal polarity. An older varve sequence (156 varves), probably dating from the Vintapper Interstadial/Low Baltic Stadial transition, also possesses negative polarity.


Current guidelines recommend continuation of dual anti‐platelet therapy (DAPT) for 12 months after percutaneous coronary intervention (PCI). Recent studies have shown benefit in continuing DAPT beyond 12 months but at the risk of increase bleeding. To date, there has been little data on risk stratifying patients to determine who can continue DAPT beyond 12 months at minimal bleeding risk. Methods: All patients who underwent drug‐eluting stent (DES) placement from January 1, 2013 to September 30, 2014 were reviewed. Patients who had follow‐up for at least 12 months, placement of 2nd generation everolimus‐coated DES, and were on DAPT for at least 12 months were included. Patients with a history of atrial fibrillation, follow‐up time less than 12 months, or were on concurrent oral anticoagulation therapy were excluded. Results: Five hundred thirty‐one patients were analyzed as described above. Two hundred two patients included in our study with 7 patients in the bleeding cohort and 195 patients in no‐bleed cohort. The HAS‐BLED score in patients who had a bleeding episode vs. those who did not was 3.29 vs. 2.24 (P value of 0.0009). Although not statistically significant, patients who had a bleeding episode were more likely to have renal dysfunction, alcohol use, be on prasugrel, and be on 325mg of aspirin. Conclusion: The study shows that the HAS‐BLED score can be of utility in risk stratifying patients in determining who can continue DAPT beyond 12 months. Furthermore, a HAS‐BLED score of less than 2 may help guide extended DAPT beyond 12 months at minimal bleeding risk. © 2016 Wiley Periodicals, Inc.


The resistivity rho has been measured between 0.04 and 7K for 'pure' polycrystalline ingots of silver, in a dilution refrigerator with a SQUID null detector system. The measurements confirm the existence of a substantial temperature range where rho - rho 0 varies as T4. At the lowest temperatures rho - rho 0 varies as T2.19, which strongly suggests that an electron-electron scattering T2 regime may be reached using a higher-precision measuring technique.


The method of in situ hybridization (ISH) using non-radioactive detection systems has become a very important molecular tool in research and diagnosis. However, nonradioactive ISH techniques generally detect only relatively abundant DNA or RNA molecules. The methods of target amplification, which multiply target molecules, or the methods of signal amplification, which increase the sensitivity of visualization, have been introduced for the detection of rare targets. Polymerase chain reaction (PCR) has been employed in most approaches to target amplification. Although the general principle of PCR in situ amplification is simple, its practical methods have revealed poor amplification efficiency and reproducibility as well as target localization. We have evaluated PCR in situ amplification methods to detect single copies of viral DNA with an experimental model of cervical carcinoma cell lines, and compared them with catalyzed signal amplification methods that we have developed using hapten-conjugated tyramide. Both amplification methods demonstrated the capability of detecting a single copy of DNA. In this overview, the applications and limitations of both target and signal amplification are summarized.


This paper presents a new image retrieval method suitable for a large-scale image filing system used in, for example, medicine. Keywords for image retieval may be more ambiguous than those for document retrieval, and the meaning of the keywords depends on each user. In order to overcome this problem, we introduce two concept spaces into the retrieval method: one of the user, and the other of the system. The mapping relation between the two concept spaces is then updated through the learning process, so that the retrieval system can be optimized for each user. An optical implementation of this system is also proposed to realize a fast retrieval.


Abstract In the 1990s, the growing income inequality is well known in some countries. Many scholars have studied and proposed their explanations of the phenomena. This paper primarily focuses on the effects of growing income inequality on the demand for farming products. In order to analyze the effects, we will construct a demand curve by using the bivariate probability distribution method. By using the properties of the newly constructed demand curve, we can find that the growing income inequality will decrease the quantity demanded of farming products, and that will cause the decline of farmers' income. Thus, it would fall into a vicious circle.


Purpose
The scenario of clean wines is rather articulated, and many consumers perceive diverse types of wines as a homogeneous category, not actually related with the true characteristics of the products. Additionally, most often, individuals turning to these wines are driven either by health concerns or environmental consciousness or by curiosity. The purpose of this study is to understand whether there are differences in monetary preferences for four distinct clean labels and to analyze the level of interest of diverse market segments of regular wine consumers for this specific category of wines.

Design/methodology/approach
This study applied a computer-assisted Web interviewing technique. A survey was administrated in mid-September 2021 by a professional panel provider to a quota-based sample (N = 1,113) of Italian regular wine consumers. Individual willingness-to-pay (WTP) for red wines carrying different claims (organic, natural, low-sulfites and no-additives) and a conventional counterpart were collected. Clean wines' WTP were subsequently used for hierarchical clustering.

Findings
Among the clean labels presented, respondents reported a higher WTP for organic wine. Cluster analysis yielded three actionable segments: "Easygoing wine enjoyers" (63.7%), "Convenience drinkers" (13.4%) and "Clean wine passionate" (23%). The latter reveals high preferences for all the investigated clean wines.

Research limitations/implications
Sociodemographics and wine-related characteristics of regular wine consumers particularly interested in clean wines are depicted in this study; further analysis should delve on the core drivers of individual preferences.

Practical implications
Wineries should consider the heterogeneous interest of regular wine consumers for clean wines, developing tailored strategies for specific market segments. Stakeholders interested in safeguarding consumers should carefully monitor the landscape of different clean claims entering the wine market.

Originality/value
To the best of the authors' knowledge, no previous study has simultaneously analyzed regular wine consumers' preferences for the four types of clean labels.


an efficient inventory Abstract: Inventory constitutes a major segment of total investment in manufacturing companies, therefore its management remains very crucial. This study therefore examines the effect of Inventory Management on the profitability of the manufacturing industry. The objectives of the study are to examine the effect of Inventory management on return on asset, investment, net operating margin, and net income of manufacturing firms in Nigeria using manufacturing companies in food and beverages operating in Nigeria as at the time of this study. This study employed the ex-post facto research design and covered a period of 5years from 2015 – 2019. Both descriptive and inferential methods of data analysis were employed. The study reveals that inventory management has significant effect on return on asset, investment, net operating margin, and net income of manufacturing firms in Nigeria. Based on the findings of this study, the following recommendations were proffered: management should avoid tying down of capital on inventory by employing Just-in-Time (JIT) system of inventory; they should also reduce credit sales or average collection period for easy conversion of inventory to cash. This will enable companies to have enough cash to settle their obligations as at when due; the companies should maintain a closer watch on their inventory conversion period by constantly reviewing processes of payment by creditors so to avoid liquidation. and professionals in the field of inventory management should be hired by these companies for advice.


Regularizing motion field is critical to achieve accurate estimation of the motion field. As the motion field may include discontinuity (e.g., at the motion boundaries), traditional smoothness regularization may not work well. Among many approaches to handling motion discontinuity, recent attempts pursued a sparse representation of the motion field for regularization, and achieved quite encouraging results. However, statistics show that these methods tend to over-sparsify the motion field, and thus confronted by the non-sparse noise in practice. In this paper, we propose to decompose the motion field into sparse and non-sparse components for the motion boundaries and small universal noises, respectively. This separation approach regularizes these two sources differently. We propose a novel and efficient optimization algorithm to solve this problem. In addition, our study reveals the in-depth connection between this noise separation approach and the influence function approach in robust statistics. We validate and evaluate our new approach on the Middlebury benchmark, and have achieved outstanding testing performance.


Any pair of two‐dimensional anisotropic media with local conductivity tensors that are functions of position and that are related to one another in a certain reciprocal way are considered. It is proved that their effective conductivity tensors are related to each other in the same way for both spatially periodic media and statistically stationary random media. An inequality involving the effective conductivity tensors of two three‐dimensional media that are reciprocally related is also proved. These results extend the corresponding results for locally isotropic media obtained by Keller, Mendelsohn, Hansen, Schulgasser, and Kohler and Papanicolau. They also yield a relation satisfied by the effective conductivity tensor of a medium reciprocal to a translated or rotated copy of itself.


It has been a long history for the widely existed temples in Southern Jiangsu province.In order to feed the monks,these temples have their own property to support religious activities,and in which land is an important part of the temples' immovable property.The resources of the temple lands are diversified.Emperors bestowed,believers donated and monks collected were the main resources of temple lands.The paper is to analyze the resources of the lands based on the survey and research of the records of temples,the inscription materials,the local chronicles,and the investigation of local villages.


Background: T cell-based interferon-γ (IFN-γ) release assays (IGRAs) are novel tests for latent tuberculosis infection (LTBI). It has been suggested that T cell responses may be correlated with bacterial burden and, therefore, IGRAs may have a role in monitoring treatment response. We investigated IFN-γ responses to specific TB antigens among Indian health care workers (HCWs) before, and after LTBI preventive therapy.


The present study has sought to investigate secondary teachers' and students' perceptions of Teaching English through English (TETE). Specifically, it examined whether and how teachers' and students' perceptions differ in terms of four major themes: its necessity, educational models, advantages and difficulties. To this end, 50 in-service teachers and 125 students at secondary schools in Busan were asked to respond to a 27-item questionnaire. The major findings from chi-square analyses are summarized as follows: (1) both the teachers and the students showed positive attitudes towards the necessity of TETE; (2) the teachers expressed lack of confidence in their English ability to implement TETE; (3) both the groups perceived TETE more suitable for teaching listening and speaking skills; and (4) both the groups felt that large class size and Korea Scholastic Aptitude Test (KSAT) are the biggest obstacles to implement TETE in secondary English classes. Finally, pedagogical implications and directions for future research are suggested.


RCFC is one part of a CED strategy which Revelstoke residents have developed in the past decade in response to an economic crisis. Government and private sector decisions taken irregardless of the town's interests severely threatened its way of life. Rather than die on the vine, Revelstoke sought both to restore and diversify its economic base. Between the creation of RCFC, downtown revitalization, development and diversification of small businesses, and the encouragement of tourism, the community's economy has come to feature four primary components, each of almost equal importance: the forest industry, transportation (primarily rail), tourism, and government. Other communities are starting to take a keen interest in this historic endeavour. This article documents the context, history, and challenges of one aspect of this accomplishment: the establishment of Revelstoke Community Forest Corporation.


The fabrication of waveguides inside transparent media using ultrashort laser pulses has gained a lot of interest during the past years. When these intense pulses are tightly focused inside the material a refractive index increase in the focal volume can be achieved. Low-loss waveguides and true three-dimensional integrated optical devices have been produced by this direct writing technique in silicate glasses. However, other materials like phosphate glasses or crystalline quartz show a different behavior. In this case stress is induced around the focal volume leading to a refractive index increase in the surrounding areas (inverse profile). As a consequence high quality waveguides with a mode profile matched to conventional fibers cannot be fabricated. In this presentation we demonstrate a new approach to overcome this problem. The laser beam is split by a transmission grating and simultaneously focused at two different areas. When the distance between the two foci is appropriate the desired refractive index profile is obtained. We will demonstrate high quality waveguides in crystalline quartz and in phosphate glasses produced by this technique. The influence of the processing parameters is discussed in detail.


Abstract : Since synchronization of transverse oscillations of a laser can result in scanning of output radiation, the distribution of amplitudes and phases of transverse modes of laser oscillations was analyzed to correspond closely to conditions in real lasers. It was found that as the synchronized transverse modes increase in number, the modulation of the laser output radiation rises sharply. (Author)


Objective To study the effect of quercetin on proliferation and apoptosis of HO-8910 ovarian cancer cell in vitro.Methods The proliferation of cells was detected by MTT method.Cell cycle and apoptotic percentage were analyzed by flow Cytometry(FCM).The expression of p53 and Bcl-2 were analyzed by FCM.Results Quercetin could inhibit the proliferation of HO-8910 cell as direct relation of concentrations and times.The flow cytometry showed that the proportion of G1 phase and the apoptotic rate were increased significantly in quercetin groups,the proportion of S phase and G2/M phase was reduced.In the FCM quercetin induced upregulation expression of p53 and downregulation expression of Bcl-2.Conclusions Quercetin could inhibit growth and induce apoptosis of ovarian cancer HO-8910 cell.Cell cycle was controlled in G1/G0.Meanwhile,quercetin could induce upregulation expression of p53 and downregulation expression of Bcl-2,while may be the mechanism of apoptosis of ovarian cancer by quercetin.


The concept of Storm-water Best Management Practices(BMP' s) has begun to alter the designs of urban storm water systems.For instance,on-site permeable pavement,vegetal beds,dry wells rock-filled trench,open ditch,infiltrating basin, percolation basin,wetland,retention and detention have been adopted as effective measures.Over the years,some failures have caused standing waters,prolonged draining process and frequent clogging etc.Many of these problems were induced by the fact that the current design approach of storm water storage systems only focuses on surface hydrology and ignores the subsurface constraints.As a result,when the subsurface seepage rate cannot sustain the surface infiltrating rate,the system fails to function well.This paper presents a new concept to combine subsurface and surface requirements into storm water basin designs.Three examples are used to illustrate the method of calculating basin storage volume and basin geometry of retention basin and its sustainability of long-term operation.


Satellite derived sea surface temperatures (SSTs) are often used as a proxy for in situ water temperatures, as they are readily available over large spatial and temporal scales. However, contamination of satellite images can prohibit their use in coastal areas. We compared in situ temperatures to SST foundation (~10 m depth) at 31 sites inshore of the East Australian Current (EAC), the dynamic western boundary current of the south Pacific gyre, using an area averaging approach to overcome coastal contamination. Varying across- and along-shelf distances were used to area average SST measurements and de-correlation time scales were used to gap fill data. As the EAC is typically anisotropic (dominant along-shore flow) the choice of across-shelf distances influenced the correlation with in situ temperatures more than along-shelf distances. However, the "optimal" distances for both measurements were within known de-correlation length scales. Incorporating both SST area and time averaging (based on de-correlation time scales) produced data for an average of 96% of days that in situ loggers were deployed, compared to 27% (52%) without (with) area averaging. Temperature differences between the in situ data and SSTs varied depending on time of year, with higher differences in the austral summer when daily in situ temperatures can range by up to 4.20°C. The differences between the in situ and SST measurements were, however, significant with or without area averaging (t-test: p-values < 0.05). Nevertheless, when using the area averaging approaches SSTs were only an average of ~1.05°C different from in situ temperatures and less than in situ temperature fluctuations. Linear mixed models revealed that latitude, distance to the coast and nearest estuary did not influence the difference between the in situ and satellite data as much as the water depth. This study shows that using de-correlation length and time scales to inform how to process satellite data can overcome contamination and missing data thereby greatly increasing the coverage and utility of SST data, particularly in coastal areas.


Physiological Basis of Muscle Electrical Potentials. Dr. Gilbert Ling. When electrodes are placed on the surface of a single muscle fiber, two types of electrical potentials are likely to be recorded. They are, respectively, the end-plate potentials and the action potentials. Both are transient variations of a steady potential difference across the cell surface, namely, the resting potential. The resting potential is therefore the physiological basis of the muscle potentials. More precise studies of such potentials have been made possible by the development of a microelectrode technique. Such studies led to possible explorations into the physical mechanism underlying the resting potential and its variations. The older "membrane theory" of Bernstein and its various other modified forms were discussed and their inadequacies mentioned. Finally, a new theory, the "fixed charge hypothesis," was presented. Electrical potentials and the unique ionic distribution inside and outside the cells, which lead to their crea¬ tion, were then discussed in the light of the present theory.


A method for triggering a signal for separating input and output train of a motor vehicle with an automated clutch, characterized in that depending on the change of the clutch torque and wherein a time (t


A 82 year old woman presented with a growing lesion of the right mandibular border. A clinical diagnosis of basal cell carcinoma was made and removal with a suitable border was planned


Mating behavior in the cashew-sunflower strain of Oncopeltus fasciatus (Dallas) is described. Both normal and castrated males kept at 30°C first become sexually active at 5 days of age, attacking females and other males. Male sex drive continues to increase until the 11th day, and can be intensified by isolation for 1 or 2 days. Females are passive except for marked avoidance behavior on the 1st day of age and become fully receptive by the 3rd day; a copulation on the 1st or 2nd day causes high early female mortality. Neither the developmental stage of the ovaries nor the presence of sperm in the spermatheca influences mating in the female. When mature, both sexes can copulate several times in 1 day; neither the duration of the previous copulation nor the occurrence of sperm transfer influences the time interval between copulations, male drive, or female receptivity. The probability of sperm transfer increases with copulation duration, which can vary from less than 1 to more than 10 hours. Copulation time tends to be unusually long with very young females and relatively short with castrate males. The variety of sexual behavior evolved in various Hemiptera is discussed.


Multi-agent systems have attracted much attention in the recent years due to their capabilities to handle complex and computation-heavy tasks and compatibility with incentive schemes. Considering the difficulty of creating an actual prototype and environment for evaluation, a simulation platform is a cheap and efficient way in analyzing and testing, prior to real environmental implementations. Existing simulators for multi-agent systems are inadequate to analyze the effects of different customized incentive schemes on agents' behavior patterns due to two reasons: 1) They lack the functionality to support various types of complex incentives, e.g., mixture of monetary incentives and non-monetary incentives, which influences agents' behaviors explicitly and implicitly; 2) They are not able to emulate heterogeneous agents' realtime behaviors that are influenced by complex incentives and deviate from their original behavior patterns shown in historical traces. In this paper, we focus on mobile agents that can move in a patio-temporal space, and we present a physical knowledge aided multi-agent simulation platform considering the influence of both direct and indirect incentives unified through a general utility-driven agent reaction function. The behaviors of agents are then emulated in three behavioral models: myopic, semi-myopic, and farsighted, by varying the assumption of agents in maximizing their utilities and integrating the physical knowledge and historical mobility patterns. We finally examine the effectiveness of the platform in incentivizing vehicle agents to optimize the final distribution of the agents through a ride-sharing vehicle experimental scenario. The emulated agents' behaviors can also be collected into data traces for analyzing other patterns of the agents.


Background: The assessment of hormone receptors (HRs) and human epidermal growth factor receptor (HER)-2 are necessary to select patients who are candidates for hormonal and anti–HER-2 therapy. Several retrospective reviews suggest change in tumor phenotype during breast cancer progression. The aim of this prospective study is to investigate discordance in receptor status between primary and recurrence disease and to assess its impact on patient management and survival. Patients and methods: One hundred patients with breast cancer progressive disease were recruited and underwent histopathological sampling. All biopsies were analyzed for ER, PR, and HER2 using similar methodology in the same lab by the same pathologist for both Primary and metastases disease. Results: Seventy four patients (74%) maintain the same tumor phenotype [i.e. the same hormone receptors (HR) and HER2 status] at recurrence, while 26 patients (26%) had discordance in tumor phenotype during progression. Biopsy led to a reported change of management in 18% of patients (P=0.003).Rates of discordance were 20%, 32%, 16% and 10% for ER, PR, HR and HER2, respectively. Tumor phenotype discordance was associated with worse time to treatment failure (TTF) and overall survival (OS) (P < 0.001 and P = 0.003, respectively); those cases who turned into triple-negative experienced the poorest TTF and OS outcome, respect to the concordant group (P < 0.001 for both TTF&OS). Conclusion: Tumor phenotype discordance is a fact and is associated with detrimental effects on outcome and led to altered management. Tissue confirmation should be considered as a routine in breast cancer patients with suspected metastatic recurrence whenever feasible. [Hesham Tawfik, Ahmed Menaisy, Amr Elbadry,Hesham Elhamzawy. The impact of tumor phenotype (Hormone Receptor and HER-2) discordance during breast cancer progression on patient management and survival. Life Sci J 2014;11(11):1027-1035]. (ISSN:1097-8135). http://www.lifesciencesite.com. 178


Our previous paper showed fragmentary evidence that pulp brightness reversion may be negatively affected by its organically bound chlorine (OX) content. A thorough investigation on eucalyptus kraft pulp led to the conclusion that OX increases reversion of certain pulps but this trend is not universal. Alkaline bleaching stages decrease reversion regardless of pulp OX content. Pulps bleached with high temperature chlorine dioxide revert less than those bleached with conventional chlorine dioxide in sequences ending with a chlorine dioxide stage but similarly in sequences ending with a final peroxide stage. The use of secondary condensate for pulp washing decreases reversion.


In this paper,a new method for fault diagnosis of rotating shaft system is presented.It is based on multi-resolution singular spectrum entropy and support vector machine.The measured signals are decomposed to different frequency bands by Mallat's wavelet algorithm,and then the signals in various frequency bands are reconstructed.The feature vectors of signals can be made by the singular-spectrum entropies that are obtained from the singular values of a series of attractor trajectory matrices.Multi-SVMs are used to identify the fault classification for the feature vectors.As an example,an experiment platform with data acquisition system was built which is employed in simulating the various faults of ship rotating shaft system.The experiments indicate that the proposed method can acquire the feature vectors of various fault modes,and thus classify the fault modes effectively.


An in-vivo sensing device for detecting in-vivo pathology may include an illumination source for illuminating light onto a tissue external to the device and an optical system for collecting fluorescent light emitted from the tissue onto a light sensor also provided within the device. A method of detecting in-vivo pathology by collecting fluorescent light emitted from a tissue is provided.


SUMMARY This working paper reviews the status of implementatio n of the Aeronautical Fixed Service, with special emphasis on the analysis of the ATS printed and voice communications requirements to be supported by the E/CAR AFS digital network and other networks at the boundaries of the CAR/SAM Regions within the area covered by this meeting. It is expected that the meeting will identify the requirements still not implemented in accordance with the plan and/or that are not being satisfactorily met by the current AFS networks. This paper also proposes to the meeting to suggest actions in order to develop the AFS communications towards the AMHS-ATN implementation. References:


Field and greenhouse studies were conducted in 1990 and 1991, to assess the effects of fertilizer application on the bionomics and population dynamics of cowpea aphid, Alphis craccivora Koch, and on the growth and yield of cowpea, Vigna unguiculata (L.) Walp. Five fertilizer regimes were applied to seedlings of aphid-resistant (cv. ICV12) and aphid-susceptible (cv. ICV-1) cowpeas. Treatments consisted of: NH4NO3 at 40 kg/ha, P2O5 at 20 and 60 kg/ha, NH4NO3 at 40 kg/ha plus P2O5 at 60 kg/ha, and no fertilizer. Test plants were initially infested with five adult apterae or were left uninfested. Treatments were maintained for 22 days. Response variables recorded included extended leaf heights (cm), aphid counts and crop growth rate (g/dm2 land area/ day). At harvest, pods per plant and seeds per pod were also recorded. ANOVA indicated significant differences in crop growth rate between infested and uninfested ICV-1 plants, and also between infested plants of ICV-1 and ICV-12; except for the 20 and 60 kg/ha P...


"Migrants as Place-Makers" investigates the role of technical communicators in determining where place could be made. Most discussions find place in locations that accommodate people through community functions, social interactions, and commercial exchanges; however, not much has been considered in how place is made through necessity. This paper applies place methodology to water stations for migrants left on the US-Mexico border by the organization Humane Borders. Humane Borders locates water barrels based on proximity to border, migrant water consumption, and rates of vandalism of water stations. Overall, migrants can make place at water stations, decreasing the likelihood of water station relocation and increasing the chance of migrant hydration. Two research questions organize this paper: How are technical communicators predicting the best location for a water station? How can technical communicators better predict the next location for a place and lessen the frequency of relocation if a water station does not become a place to migrants? Place and space methodology asks the field to consider migrants as interlocutors between place and technical communicator to better (re)locate water stations and lessen the frequency of relocation. These questions are answered through a case study of two water stations where I find that when migrants recognize a water station as a place, it deters vandalism. Thus, technical communicators should especially promote place-making at frequently vandalized water stations.


This paper investigates the performance of the manufacturer and the e-tailer under the influence of a vertical variable (cross-channel effect) and a horizontal variable (e-tailers' competition) in the dominant e-tailer structure. A game theoretic pricing model of one common manufacturer and two e-tailers is built. Then, the corresponding equilibrium solution is derived from the model. Then, a comparison between the equilibrium results of the dominant e-tailer power structure and the dominant manufacturer power structure is performed. It is found that in the dominant e-tailer power structure, the equilibrium exists only when the cross-channel effect is positive and the competition parameter is not large.


The temptation to influence and sway public opinion most certainly increases with the growth of open online forums where anyone anonymously can express their views and opinions. Since online review sites are a popular venue for opinion influencing attacks, there is a need to automatically identify deceptive posts. The main focus of this work is on automatic identification of deceptive reviews, both positive and negative biased. With this objective, we build a deceptive review SVM based classification model and explore the performance impact of using different feature types (TF-IDF, word2vec, PCFG). Moreover, we study the transferability of trained classification models applied to review data sets of other types of products, and, the classifier robustness, i.e., the accuracy impact, against attacks by stylometry obfuscation trough machine translation. Our findings show that i) we achieve an accuracy of over 90% using different feature types, ii) the trained classification models do not perform well when applied on other data sets containing reviews of different products, and iii) machine translation only slightly impacts the results and can not be used as a viable attack method.


e16074 Background: Men with prostate cancer (PC) on androgen deprivation therapy (ADT) are at risk of osteoporosis and fragility fractures. Comprehensive evaluation and management of bone health in...


Junior counselors in North Carolina are following an interesting program which coordinates the youth-serving agencies available in a community. The schools, private industry, the National Youth Administration, the State Employment Service are all cooperating in the guidance, training and placement of youth. Some valuable suggestions are offered by the writer.


The main object of this paper is to study the changing structure and direction of Foreign Direct Investment of India and China comparatively. It is well known that FDI can complement local development efforts in a number of ways, including boosting export competitiveness; generating employment and strengthening the skills base; enhancing technological capabilities and increasing financial resources for development. Global Foreign Direct Investment (FDI) inflows rose modestly by 5 percent, to reach $1.24 trillion in 2010. While global industrial output and world trade are already back to their pre-crisis levels, FDI flows in 2010 remained some 15 percent below their pre-crisis average, and nearly 37 percent below their 2007 peak. UNCTAD predicts FDI flows will continue their recovery to reach $1.4-1.6 trillion, or the pre-crisis level, in 2011. They are expected to rise further to $1.7 trillion in 2012 and reach $1.9 trillion in 2013, the peak achieved in 2007.The service sector has attracted highest (21 percent) FDI inflows; then computer software, and hardware (9 percent), telecommunication sector (8 percent) and Housing and Real estate (7 percent) during 2008 to August 2010. Mauritius (42 percent to total inflows of FDI) has been largest investor in India, followed by Singapore (9 percent) during 2008 to August 2010 among top ten countries. China's highest FDI inflows in leasing and business service 30280.70 million USD in 2010. Second sector is Banking (8627.39) followed by wholesale and retail trade, mining, transport, storage and post etc. during the same period.In short, comparatively the global FDI inflow in China is highest than India in 2010. The sector wise FDI inflow show that, a highest FDI inflow to India is in housing and real estate. But China's FDI inflow is Business service and Banking in study period.


Objectives: The purpose of this study was to determine and inform clinicians, managers, and budget allocators of the costs incurred to the British National Health Service (NHS), patient, and society when attending clinic-based physiotherapy compared with not attending clinic-based physiotherapy after arthroscopic partial meniscectomy surgery. Methods: The valuation principle used in this study was the economic concept of opportunity cost. Costs were referred to as direct medical (NHS), direct nonmedical (patient), and indirect (societal) costs. Due to the difficulties of their measurement and valuation, intangible costs, in the form of pain and anxiety related to the effect of receiving or not receiving treatment, have not been considered in this analysis. Results: Providing clinic-based physiotherapy after knee arthroscopic partial meniscectomy surgery is more costly to the NHS and patient, but no more costly to society than when not providing it and does not result in reduced contact with the NHS. Conclusions: Clinic-based physiotherapy after knee arthroscopic partial meniscectomy surgery is costly and evidence is needed that its effectiveness is high enough to support its use.


Several compositional features of sedimentary deposits can be used to reconstruct environmental conditions of source areas. In this research, bulk X‐ray diffraction mineralogy, heavy and clay mineral assemblages and geochemistry obtained for modern deposits of the Cunene River and its tributaries Caculuvar–Mucope are integrated with geological/geomorphological characteristics of respective catchment areas to evaluate to what extent sediment production is spatially variable and source materials are differently affected by exogenous transformations. Detrital sources can be classified into four main types based on sediment composition: felsic, mafic, recycled and mixed. Source contributions obtained with unmixing models using distinct input data reveal some disagreements, with heavy mineral assemblages pointing to higher mafic contribution and bulk XRD‐mineralogy favouring the recycled sedimentary component. However, the three datasets coincide showing a lower supply from the Kalahari Basin than the large outcropping areas of its sedimentary units would suggest, which is attributed to the relatively low rainfall and relief in this region. Where multiple depositional cycles are involved in sediment production the composition of the river deposits, even their clay fractions, will not reflect coeval weathering transformations and an under‐estimation of the mafic component probably occurs. This research reveals how exogenous processes may deviate the composition of the produced sediment from a simple weighted by outcropping area average of the source units and compromise (palaeo)environmental interpretations based on sediment composition.


The miao of China has always unique and colorful nationality clothing.Its clothing shows rich color,luxuriant design,elegant and heavy and complicated silver design distinctive aesthetic features,collects the history and culture of miao miao,contains the people's pursuit of beauty and create,reflects the miao people's advocate natural,positive aesthetic consciousness and aesthetic ideal,and its is miao people's crystallization of the wisdom of aesthetic ideal and chemical.


Airgap and stator flux field orientation control (FOC) methods are discussed as an alternative to the familiar rotor flux orientation approach. The principal motivation is the relative accessibility of the two alternative fluxes. Motor flux models are developed in a unified manner, and it is shown that inherent coupling between flux and torque exists in the stator and airgap models. Two decoupling methods are presented. Simulation results are given for an airgap oriented control; the performance approaches that of a rotor flux oriented drive. >


The 1st of January 2007 marked Romania's accession to the European Union (EU) and represented its 'ticket' to a free access to the common market. This soon evolved into an important trigger for the increased migration flows from Romania towards the more developed western countries, members of the EU. Not only the opportunity of a free movement of persons – emerged with the integration - but also the existing socio-economic disparities between Romania and the more developed western countries in the EU, led to unidirectional migration flows. Using both static and dynamic panel gravity models, we aim to identify the main determinants of Romanians' migration towards 10 EU member states – Czech Republic, Denmark, Italy, Netherlands, Finland, Germany, Norway, Poland, Spain, and Sweden – for the period 2007-2014. Our empirical findings support the results of other studies performed on different economies. The most important pull factor for Romanians' migration is represented by the economic conditions in the destination countries, proxied by the GDP/capita. Other important pull factors fuelling Romanians' migration refer to the unemployment rate, life expectancy, education spending, and population density. A key role is also played by the existing social networks in the destination countries which are proxied in our model by the lagged migration flows.


Low-viscosity, methoxylated polysiloxane resins incorporating Me 2 SiO 2/2 (D) and SiO 4/2 (Q) units were prepared using nonhydrolytic condensation between Si-Cl and Si-OMe groups with the formation of MeCl, catalyzed by a Lewis acid. With the commonly used catalysts, condensation between two Si-OMe groups, with formation of Me 2 O, also took place to a large extent, hindering the control of the degree of condensation of the resins. Several catalysts were tested by monitoring the formation of MeCl and Me 2 O using sealed NMR tubes and 1 H-NMR spectroscopy. The best compromise between reactivity and selectivity was obtained with ZrCl 4 . Resins with various compositions were prepared in the absence of solvent by condensation between Me 2 SiCl 2 and Si(OMe) 4 at 130°C, catalyzed by 1 mol % ZrCl 4 . They were characterized using viscosimetry, gas chromatography coupled with mass-spectrometry (GC-MS), and quantitative 29 Si-NMR spectroscopy. The resins consisted of a complicated mixture of oligomers, linear or branched (n > 1) and cyclic (n > 3), with a high degree of D/Q bonding. The distribution of Si-OMe and Si-OSi bonds and the bonding between D and Q units were found to be nearly random. This was ascribed to the occurrence of Si-OSi/Si-OMe and Si-OSi/Si-OSi redistribution reactions that reached equilibrium during the synthesis.


Background: The neonatal period (first 28 days of life) is the most critical time for a child's survival. Neonatal mortality risk factors are complex, relatively improved slowly, but remains a major concern in developing countries. In developing countries where there is no satisfying registration and as most complicated cases referred to medical city complex, trying to determine the causes of neonatal mortality let to put strategies' that will help in reducing it. Objective: To evaluate the neonatal mortality potential risk factors. Methods: We reviewed all medical records of neonates that hospitalized in the neonatal intensive care unit (NICU) at Baghdad teaching hospital from 1 st December 2016 and 31st January 2017. Analyzed variables were sex, birth weight, gestational age, maternal age, place of delivery, mode of delivery, and sepsis. Subjects were enrolled; that is 208 cases 91died. Results: The total births during this period of study 2071 births, 1259 deliveries through caesarian section still birth 21 while normal vaginal deliveries 812, 42 dead births. NICU admission 208 with neonatal mortality rate 43.8%. Prematurity was the major cause of death 61.5%. multiple pregnancies with unplanned operation increased prematurity incidence, shortage of resuscitation equipment and limited training of nurses and doctors working in obstetric and neonatal care ward may attributed to increase mortality. Conclusions: Neonatal mortality is high; the Majority of the deaths were males in early neonatal period. The neonatal mortality risk factors in the NICU are preterm, labour complication, congenital anomaly and sepsis, in order to reduce morality we have to establish more trained centers with well qualified person.


Tunable filter circuit (100) with an active filter (110) having a plurality of first linear electronic elements (114, 116), which are arranged as a switchable field (113) and comprise a combination of several permanently connected elements and a plurality of switchable elements which have the same value, and at least one second linear electronic element (112), said first linear electronic elements (114, 116) having an electrical characteristic which is represented by a first circuit design value, and the at least one second linear electronic element (112) has an electric property, which by is representative of a second circuit design value, wherein the first and second linear electronic elements (112, 114, 116) essentially determine a time constant of the active filter (110); and an adjustment circuit (120) for outputting a digital code (n) to the array (113) of the first linear electronic elements (114, 116) to adjust the time constant of the active filter (110) approximately at a predefined value, wherein the adjustment circuit ( 120) comprises: ...


China's agricultural development in recent decades is impressive. Its farmers continue to feed the world's largest population and China's crop yields are well above global averages. Yet rural incomes have been stagnating, with wide and growing geographic disparities. Overall, China's median net per capita rural income is low, estimated at US$317 in 2003. Nevertheless, Chinese agricultural development faces other challenges. In China's northern region, for example, water use appears to be on an unsustainable trajectory. The chemical intensity of Chinese farming is high by global standards and is a growing source of public health risk. Technologically, China could benefit from advances in biotechnology and irrigation science, but the successful deployment of these technologies will also depend on well-functioning institutions. In this article, we introduce a reform agenda to address China's rural poverty and sustainability challenges, based upon an assessment of the primary resources used in China's agricultural sector: labor, land, water and technology. The reform agenda we present is unconventional, but we believe it opens new opportunities for meeting China's objectives for rural and national economic growth, water and environmental sustainability, and food security.


Carrier-to-photon lifetime ratio is a key parameter in the non-linear dynamics study of quantum cascade lasers under external optical feedback. We experimentally investigate the influence of temperature on this parameter and hence on chaotic behaviors.


Within a mere hundred years from the appearance of the first telephone in Zagreb in 1881 until the establishment of the first electronic telephone exchange in 1981, telephony in Zagreb went through several formative periods to assert itself. Zagreb was transformed from a provincial town in the Austrian-Hungarian Monarchy to the economic and cultural centre of Croatia. In that period, due to technological development, many changes took place that influenced the accessibility and price of the most popular telecommunications technology in the 20th century. At first a status symbol reserved for the wealthiest citizens, telephone gradually became accessible to all inhabitants of the city. In the decades after World War II, the new telephone infrastructure was constructed under the unfavourable conditions of technological underdevelopment, scarcity of professionals, and meagre financial resources. Nevertheless, despite all the aggravating circumstances, telephony managed to become an inevitable part of Zagreb's everyday life. Modern telecommunications rest on these very steps that fixed telephony took in its development, and are therefore an indicator of the technological as well as cultural development of Zagreb.


A seat track assembly includes a movable rail which is arranged such that it bears a seat and a stationary rail, which is adapted for attachment to a floor structure. The movable rail is selectively relative to the stationary rail in a variety of use positions. The movable and stationary rail included end stop structures which cooperate to adjust the entire length of movement and the movement-center position of the movable rail relative to said stationary rail.