Purpose

– This paper aims to summarize and review the opportunities and challenges that India offers in terms of leveraging the cultural and economic potential of the fairs and festivals.

Design/methodology/approach

– The paper draws from the findings of the theme issue contributors. All the papers in the theme issue have drawn inputs from diverse types of fairs and festivals organized in different parts of India.

Findings

– The paper summarizes the key opportunities and challenges with respect to leveraging the cultural and economic potential of fairs and festivals in India. Some of the issues that emerge across the board revolve around lack of basic infrastructure, indifferent government support, local apathy toward cultural commodification and poor stakeholder engagement.

Practical implications

– There are a number of practical implications for practitioners and policy-makers that will allow India to optimally leverage the huge cultural and economic potential that the various fairs and festivals offer, but this requires a holistic understanding that will ensure that aspirations and concerns of all key stakeholders are taken into account.

Originality/value

– The on-the-ground narrative brings out the real issues, challenges and opportunities that can then be analyzed to offer direction to policy-makers, tourism sector and government at various levels. The outcomes of the theme issue summarize the above.


This study aims to find empirical evidence in filling the "how-to" gap of a service company in order to have a sustainable competitive advantage by adopting lean system or known as a workplace organization. This study surveyed 150 customers from three largest franchise minimarts in Bandung City in order to determine the characteristics and interrelations that occur in the three research objects observed, namely 5S or workplace organization, service's waste, and service quality. The method used is descriptive method and structural equation modeling based on the least squares method or PLS-SEM. The statistical tools used are SPSS20 and SmartPLS3. The results reveals that the three largest franchise minimarts in Bandung City, had a high level of service quality, low service's waste, and well-managed workplace organization. The relationship between them shows that the three franchise minimarts continue to survive and continue to grow after operating for more than 3 decades, because they implemented a workplace organization (5S, seiri-seiton-seiso-seiketsu-shitsuke), so that this can reduce the occurrence of service's waste by 82.4 %, where even this has an impact on increasing service quality by 27.9% with a very high model strength of 73.5%.


Purpose: We have evaluated changes of body composition for patients that underwent a radical gastrectomy for stomach cancer by the use of available bioelectrical impedance analysis during the first year following surgery. We plan to utilize these findings in nutritional and physiological studies. Materials and Methods: We evaluated clinical changes in body composition in patients using the bioelectrical impedance method (Inbody 4.0, Biospace, Korea), between November 2003 to November 2004. A total of 98 patients agreed to enroll in this study among all of the patients that underwent a radical gastrectomy. Results: The average weight decreased by 6.7%, and 9.4%, within the first and 6 months after surgery, respectively (P


A large amount of information is generated across the globe through various IT enabled services. Health care industry has turned out to be the most significant and information-rich area. The term Health care is gaining popularity due to the improvement in medical science and the prevalence of new and peculiar diseases. In recent years, there is increased usage of electronic personal health care devices and consulting physicians for various illnesses that are gaining insight. Medical records are generated every second from hospital visits, inpatient wards and health care devices. These records that turn to become big data require a lot of analyses and predictions. Text mining is a broad field that needs more mining in the medical records as there are structured, semi-structured and unstructured data. This paper depicts/overlays the study of algorithms, tools and techniques involved in text mining for health care data.


Plasmapheresis is an aggressive autologous blood conservation method utilized in cardiac surgery to reduce patient exposure to homologous blood transfusion. Presently the three perioperative techniques which have been used clinically incorporate varying methodology in producing platelet rich plasma (PRP). However, no prospective randomized study has been made to concurrently examine the benefits of individual devices.
Fifty-two consenting adult cardiac patients who met selection criteria were randomly assigned to one of three plasmapheresis devices: Plasma Saver (PS), Cell Saver (CS), and Autotrans 1000 (AT 1000). Following induction of anesthesia, 20% of each patient's estimated plasma volume was removed, stored and then reinfused following the reversal of heparin with protamine. One hundred and twenty-two parameters were measured for each patient. These included anthropomorphic, operative, cardiopulmonary bypass, and postoperative follow-up parameters. Indices of hemostasis were measured which included coagulation screens and thrombelastographic data.
There were no differences between groups in all preoperative parameters including the volume of PRP removed. Fibrinogen levels in the PRP were 213.9 +/- 63, 219.4+/-73, and 188.9+/- 69mg/dl in groups PS,CS, and AT 1000 (p=NS), while platelet counts were 178.4 +/- 73, 121.6 +/- 85, and 210.6 +/- 77 109/L, respectively (p<.05 CS vs. AT). There were no differences in chest tube drainage, time on ventilator, or length of ICU stay between groups. However, patients in PS group had significantly lower discharge platelet counts than groups CS and AT 1000. Total homologous blood exposure rate (donor blood exposure per patient) was 8.2 units in group PS, 4.5 in CS, and 5.4 in AT 1000, (p=NS).
The currently available techniques for perioperative PRP production differ in both methodology and platelet yield, although the difference did not result in significantly different patient postoperative outcome indices.


Welcome to the last issue of the IEEE Transactions on Computational Social Systems (IEEE TCSS) in 2018. Starting from the first issue next year, our Transactions will be a bimonthly publication, entering a new stage for the IEEE TCSS.


Fracture-vuggy carbonate reservoirs are widely developed in the northern Tarim Basin.However due to their large burial depth,and the main reservoir space being fractures,cavities and caverns,so the exploration is difficult.Regarding the characteristics of this type reservoir,the geometry quantitative design aiming at raising signal to noise ratio and resolution was conducted through wave equation forward modeling,in order to meet the need of interpretation for fracture-vuggy reservoir,wide azimuth observation was used.By application of the technique in north Tarim Basin,excellent exploration results were achieved.


This essay demonstrates an application of prime numbers to the development of a calculator program that solves sudoku puzzles. Among the positive integers, the primes—numbers with exactly two divisors, the numbers themselves and 1—are central to our thinking about numbers. They give us a basis for factoring and divisibility and they contribute to the solution of many problems in the mathematical field of number theory. More important for the purposes of this paper, they provide a way of representing numbers uniquely by prime factors. For example, 6221592 = 23 × 32 × 13 × 172 × 23, any other factorisation differing only in the order of factors.


ObjectiveThe ideal treatment strategy for elderly patients with metastatic non-small cell lung cancer (NSCLC) is still controversial. Our objective is to implement radical local therapy to the primary tumor and all metastases in elderly patients with oligometastatic NSCLC and evaluate its long-term efficacy and safety.Patients and MethodsAll patients were older than 65 years at initial diagnosis and had pathologically confirmed NSCLC with a total of less than or equal to 5 metastases through imaging diagnosis. Radical local therapy was applied to the primary tumor and all metastases to evaluate its OS, PFS, and toxicity.ResultsA total of 30 elderly patients with NSCLC (≤ 5 metastases) received high-dose radical local radiotherapy to the primary tumor and all metastases, with a median age of 73 years (65-82 years). A total of 134 lesions were treated, with a median biologically effective dose at alpha/beta 10 (BED10) value of 102 Gy (78-119 Gy) . The median follow-up period was 34 months (10-68 months) and the median OS was 36 months. The 1-, 2-, 3-, and 5-year OS were 93.3%, 66.7%, 49.6%, and 12.1%, respectively. The median PFS was 12 months, and 1-year PFS was 36.7%. Multivariate analysis: When ECOG PS < 2 and BED10 ≥ 100 Gy, better OS was obtained (P < 0.001 and P = 0.022); ECOG PS < 2 was an independent prognostic factor for PFS (P = 0.016). Most patients experienced grade 1-2 toxicities, a few experienced grade 3 toxicity (6.66%), and no grade 4-5 toxicities and treatment-related deaths occurred.ConclusionElderly patients with oligometastatic NSCLC were given radical local radiotherapy to the primary tumor and all metastases, which improved their survival with tolerable toxicity and can be considered as an optional new treatment modality.


Data are the lifeblood o厂science and the sharing of observations and measurements has always been essential to the formulation of new concepts and the evaluation of existing ones. Since 1957, the World Data Centers have served the international community in a variety o厂disciplines and in a number of programs, including the Upper Mantle Project and the International Geodynamics Project. m earth sciences, where time and space dependent data are the rule, many years o厂monitoring observations may be needed and many locates surveyed to distinguish between transient and permanent or normal phenomena.


【Abstract】 The focused works of ecosystem management are collecting, integrating and analyzing temporal and spatial data by 5S spatial technologies. There are remote sensing (RS), permanent sampling plots (PSP), global position system (GPS), geographical Information system (GIS) and simulation modeling system (SMS) included in the 5S spatial technologies. We have to develop the spatial information of interested area in Taiwan Island. All the value of biological factors and habitat factors were developed and integrated in 40mx40m grid-based geo-database management system (Geo-DBMS). The spatial data of biosphere in GIS are multi-scale with species, population, community, ecosystem and landscape levels. Getting the spatial information of status, function and change, we have to develop and analysis temporal-spatial data with empirical models, process models and scenario simulation.


The study examines research performance of global Traditional Knowledge during the period of 1989 to 2015. A total of 24347 records were obtained for analyzing the measure of type documents, the growth of publications, authorship pattern,geographical distribution, institution wise distribution and the journal wise distribution.The result of the study is the highest publication were 2465 in 2015, among the productivity of authors during the period of study, Pieroni A and Zhang Y is the most productive authors who published each 40 papers with first place, and a among countries, the USA produced 7844 of articles and it occupied the first place.


A solution of Maxwell's moment equations is obtained for the steady, one-dimensional flow through a normal shock wave in a Maxwellian gas. The solution method makes use of a new representation for the conservation equations, a closure relation for a single third-order moment, and a spatially integrated form of Maxwell's equations of transfer. The integrated equations of transfer act as constraints in evaluating two sets of coefficients introduced in the conservation equations and the single closure relation. A total of only four coefficients are found to be fully sufficient when comparisons are made with results from the direct simulation Monte Carlo method, which show excellent agreement across all hydrodynamic variables including two fourth-order moments which the theory predicts.


Background: There are four forms of tuberculosis in the Central Nervous System. The most frequent is basal leptomeningitis, followed by intraparenchimal tuberculomas, tuberculomas en plaque and Pott's disease, in which damage of spinal cord follows the spinal tuberculosis. Encephalic tuberculomas are more common in immunosupressed. Cerebellar location is common in children. They can cause hydrocephalus, epilepsy, motor deficit and other manifestations of the encephalic mass. Objective: To inform 31 cases of intracraneal tuberculomas. Results: There were found 23 in males and eight in females, with an age range from 8 to 72 years. Thirteen were single and 18 multiple. Four were catalogued as giant. The cerebellum was the most common site. In decreasing order of frequency the following manifestations were observed: meningeal signs, intracranial hypertension and alterations of consciousness. The center of the lesions had the typical aspect of caseous necrosis and the amount of granulation tissue varied according to the age. Microscopically, all components of caseous granulomas were identified. The acid-fast bacilli were scarce with the ZN stain. Conclusions: Frequency of neurotuberculosis has decreased in the last two decades and tuberculomas are not any longer the neurosur


Fukutin is the gene responsible for Fukuyama‐type congenital muscular dystrophy (FCMD), an autosomal recessive disease associated with central nervous system (CNS) and eye anomalies. Fukutin is involved in basement membrane formation via the glycosylation of α‐dystroglycan (α‐DG), and hypoglycosylation of α‐DG provokes the muscular, CNS and eye lesions of FCMD. Astrocytes play an important role in the pathogenesis of the CNS lesions, but the post‐transcriptional regulation of fukutin mRNA has not been elucidated. In this study, we investigated the characteristics of fukutin mRNA using an astrocytoma cell line that expresses fukutin and glycosylated α‐DG. The glycosylation of α‐DG was considered to be increased by over‐expression of fukutin and decreased by knockdown of fukutin. Knockdown of Musashi‐1, one of the RNA‐binding proteins involved in the regulation of neuronal differentiation, induced a decrease in fukutin mRNA. Immunoprecipitation and ELISA‐based RNA‐binding assay demonstrated possible binding between fukutin mRNA and Musashi‐1 protein. A relationship between fukutin mRNA and vimentin protein was also proposed. In situ hybridization for fukutin mRNA showed a positive cytoplasmic reaction including cytoplasmic processes. From these results, fukutin mRNA is suggested to be a localized mRNA up‐regulated by Musashi‐1 and to be a component of a mRNA‐protein complex which includes Musashi‐1 and (presumably) vimentin proteins.


Objective\ To establish an immunoblotting test(IBT)for detecting the antibodies of extractable nuclear antigen(ENA)with rabbit thymus acetone powder made by ourselves.\ Methods\ The thymus of rabbits was separated to extract the ENA antigens. The protein of ENA antigens were separated with SDS polyacrylamide gel electrophoresis. The separated antigen proteins were then transferred onto nitrocellulose sheet to make 7.0 cm×0.3 cm slips, which were then used to react with standard positive sera or SLE patients' sera. Finally, HRP conjugated sheep anti human IgG was added for immunoblotting. Indirect immunofluorescence was used for comparison. \ Results\ 43 of 50 (86%) sera of SLE patients demonstrated ENA autoantibodies combining with ENA antigens. The positive rate of anti Sm,anti U1RNP,anti SSA,anti SSB,anti Scl 70,anti Jo 1 and anti rRNP antibodies was 52%,64%,18%,4%,6%,0 and 16%,respectively. By indirect immunofluorescence(IIF)method, 36 of 50(72%)were ANA positive, but no SLE related autoantibodies were found in 20 normal controls.\ Conclusion\ The IBT technique of self made rabbit thymus acetone powder is practical and reliable in the detection of ENA autoantibodies.


Subjectivity, as the innermost core of the private, was always already oriented to an audience. --Jurgen Habermas, The Structural Transformation of the Public Sphere Scholarly assessment of Fanny Fern has in many ways paralleled the social reception of her most popular heroine, Ruth Hall. Both are portrayed as initially plagued by an oppressive, limiting, and condescending patriarchal community. They are then critically maligned and shunned when they attempt to throw off the shackles of patriarchy in order to write and earn money as independent women. In the end, they achieve a kind of miraculous triumph in that their writings--precisely for the way they eschew convention and voice the wrongs of the oppressed--become hugely successful, earning their authors riches, fame, and a delicious revenge over the corrupt society that had previously oppressed them. Fern's triumph (and the triumph of her heroine, Ruth) lies in her ability to defy and finally to transcend the stultifying codes for "true womanhood" that subjected women to the silence, oppression, and dependency of the patriarchal home. (1) Ruth Hall is, as critics have noted, a revolutionary novel precisely for the way it employs the conventions of sentimental literature only to reveal them as, at least in part, culturally bankrupt. In place of sentiment, Fern champions the free market as a legitimate source for women's serf-fulfillment, appropriating public labor and economic acquisitiveness as acceptable, even laudable, for American women. Fern was herself a remarkably efficient and successful exemplar for such an ethic. Seventy thousand copies of her first book, Fern Leaves from Fanny's Portfolio (1853), sold in America within a year of its publication, and another twenty nine thousand copies sold in England, making Fern Leaves one of America's first best-sellers. Ruth Hall (1855), Fern's second book, sold equally well. Her popularity continued to rise (she was compared to Stowe and Dickens), and by 1855 she was making the unheard-of sum of one hundred dollars per article for Robert Bonner's weekly newspaper, the New York Ledger, a paper that benefited tremendously from its affiliation with Fern. Ruth Hall gave rise to associated products like a "Ruth Hall bonnet, in elegant black gauze," a musical score called "The Ruth Hall Schottische," and a popular song called "Little Daisy" about Ruth's daughter who dies early in the novel. (2) Fern's divided identity--on the one hand she is portrayed as subversive, unconventional, and maligned by her contemporaries, on the other her overwhelming popularity opens up entire vistas of agency and representation for those on whose behalf she ostensibly writes--reveals much about both the reformist ideals that drive sentimental fiction and the American marketplace in the mid-nineteenth century. (3) The persona that drives Fern's (and, in Fern's novel, Ruth's) popularity in the market and her controversial status in the media continually fluctuates between a beleaguered, unfairly criticized sense of authenticity, and an overwhelming popularity that results from the discovery and acknowledgment of that same authenticity. This fantasy of being recognized for a previously unacknowledged or oppressed sense of personal value is consistent with the traditional plot line of what Nina Baym refers to as "woman's fiction" in the mid-nineteenth century. (4) Ruth Hall, much like other popular woman's fiction of the day, connects her heroine's "true womanhood" explicitly to her prowess as a consumer. (5) Fern's novel imbues this formula with particular resonance and urgency, for her heroine's goodness, authenticity, and essential womanhood are repeatedly threatened, and in order to stave off those threats she must continually improvise new fashions and innovative forms of self-expression in order to keep her essential self from becoming overwhelmed by the jealous masses. The popularity of Fern's novel owes a great deal to the way it encourages readers to identify with and even emulate Ruth's productively fashionable energy. …


Combining with the work practice,the paper illustrates from the establishment of the comprehensive evaluation system,the implementation,the ways and the methods,and points out the comprehensive evaluation should go through the process of the enterprise management,which is considered as the effective management methods in enterprises.


Creativity is one of the key domains of psychological study.Thers has been some discrepancies about the concept and nature.From the perspectives of creativity and attention,creativity and psychological health,creativity and personality,this paper discusses the definition and nature of creativity and then put forwards that the nature of creativity is the ability of free diffusibility of nervous excitation.


In heart failure (HF), chronotropic incompetence is a major factor limiting cardiac output and exercise capacity. In patients carrying cardiac implantable electronic devices (CIED), accelerometer-based rate adaption (R-mode) counterbalances chronotropic incompetence during physical activity but fails to modulate heart rate under circumstances of high metabolic demand.

 We hypothesized that an activated R-mode, a surrogate of chronotropic incompetence, indicates worse prognosis during and after episodes of acutely decompensated HF (AHF).

 We analysed 632 patients enrolled between 01/2014 and 02/2018 in an ongoing registry that phenotypes and follows patients admitted for AHF. We compared CIED carriers with activated R-mode (CIED-R; n=37, 16% women) with CIED carriers not in R-mode (CIED-0; n=64, 23% women) and patients without CIEDs (no-CIED; n=511, 43% women). Information on survival status was collected up to 12 months after discharge from index hospitalisation (IH). Uni- and multivariable Cox proportional hazard regression was used to identify predictors of 12-month mortality risk.

 Mean age of the study sample was 74 (11) years, 39% were women, median LVEF on admission was 51 (quartiles 32, 59) % and de novo HF was detected in 20% of all patients. Median length of IH was 10 (7, 14) days. In-hospital mortality was similar across groups, but 12-month mortality risk was affected by chronotropic incompetence as indicated by R-mode activation: age- and sex-associated hazard ratio (HR) for CIED-R was 2.61 (95% CI 1.59–4.29, p<0.001) compared to group no-CIED, and 2.44 (95% CI 1.25–4.74, p=0.009) compared to group CIED-0. Amongst univariable predictors of mortality risk, strong associations were found for NT-proBNP levels (p<0.001), Charlson comorbidity index (p=0.001), and de novo HF (p=0.003). These effects persisted after multivariable adjustment for comorbidity burden. Within CIED-R, mortality risk was similar in patients with pacemakers vs. ICDs (HR 1.20, 95% CI 0.49–2.95) and in subgroups with LVEF <50% vs. ≥50% (HR 1.10, 95% CI 0.79–1.53). Mean heart rate on admission was lower in CIED-R vs. CIED-0 or no-CIED (70 bpm vs. 80 bpm or 82 bpm; both p<0.001). Heart rate on admission had no impact on frequency of in-hospital worsenings or death. However, we found a 36% increase in mortality risk per tertile of heart rate at discharge (HR 1.36, 95% CI 1.10–1.69, p=0.004) after exclusion of patients with an activated R-mode.

 In AHF, R-mode stimulation was associated with an increased 12-month mortality risk, independent of LVEF, type of CIED, burden of comorbidities and type of presentation. Further, increased resting heart rate at discharge predicted 12-month mortality risk only in patients without an activated R-mode. Our findings suggest that chronotropic incompetence per se worsens outcome in AHF and may not be adequately treated through accelerometer-based R-mode stimulation.

 Type of funding sources: Public grant(s) – National budget only. Main funding source(s): The Comprehensive Heart Failure Centre (CHFC) Würzburg is funded by the Federal Ministry of Education and Research, Integrated Research and Treatment Centre "Prevention of Heart Failure and its Complications".


The wood of jacaranda caviuna species (Machaerium scleroxylon Tul.) has mechanical and colorimetric properties suitable for manufacturing high quality furniture and wood-turned objects, even though it is even used for charcoal. The present study aimed to evaluate the natural resistance and color modification of jacaranda caviuna wood after whiteand brown-rotting (Trametes versicolor (Linnaeus ex Fries) Pilát e Gloeophyllum trabeum (Persson ex Fries) according to ASTM D 2017. Three logs measuring 1000 mm of length and 250 mm of diameter were collected. Twenty four samples (CP) were produced with 25 mm x 25 mm x 9 mm (length x width x thickness, respectively). The colorimetric parameters L*, a*, b*, C and h* (clarity, red pigments, yellow pigments, chromaticity and ink angle, respectively) were determined by a Data Color International Microflash (200) spectrophotometer before and after the bio-deterioration. A low weight loss (2.97% for white-rot and 2.06% for brown-rot), with high natural resistance was observed. There was a change in the colorimetric parameters after biodegradation, but according to CIE-L*a*b*, the color pattern was maintained due to the tolerable variation ranges for each parameter. Moreover, visually changes in the color of the wood were observed, classifying it as sensitive (3<ΔE *<6) for both rots.


Cities are historically created as a collaborative work of different generations and derive from the possibilities created bylocal and climatic conditions, social relations and culture. Today, urbanization may appear as a way of organizing everyday hierarchical, exclusive, discriminatory and exploitative life through industrialized mass production of temporary, privatized, homogenized, fragmented, and power-oriented spaces. This mind-set and application generates several social and ecological problems. This article discusses the right to the city concept, and links it to the deurbanization approach as a social and ecological answer to the problems associated with current urban development.  The methodology is supported by a review of the literature and an analysis of examples of works created in the De-Urban Design Studio. Results indicate that the deurbanization approach envisions creating resilient, equitable, non-hierarchical cities composed of communities that replace consumption via harmony with nature, that replace individualism and competition viacollaboration and solidarity, and that replace hegemonic relations via an equitable distribution of power.


Relational inference is a crucial technique for knowledge base population. The central problem in the study of relational inference is to infer unknown relations between entities from the facts given in the knowledge bases. Two popular models have been put forth recently to solve this problem, which are the latent factor models and the random-walk models, respectively. However, each of them has their pros and cons, depending on their computational efficiency and inference accuracy. In this paper, we propose a hierarchical random-walk inference algorithm for relational learning in large scale graph-structured knowledge bases, which not only maintains the computational simplicity of the random-walk models, but also provides better inference accuracy than related works. The improvements come from two basic assumptions we proposed in this paper. Firstly, we assume that although a relation between two entities is syntactically directional, the information conveyed by this relation is equally shared between the connected entities, thus all of the relations are semantically bidirectional. Secondly, we assume that the topology structures of the relation-specific subgraphs in knowledge bases can be exploited to improve the performance of the random-walk based relational inference algorithms. The proposed algorithm and ideas are validated with numerical results on experimental data sampled from practical knowledge bases, and the results are compared to state-of-the-art approaches.


In this paper a neurosymbolic hybrid system for robot self-localization is proposed. This crucial issue in autonomous robotic research field has been tackled with slightly different approaches depending mainly on robot sensors and actuation devices, its available computational resources, and the environment in which it acts. The system we present has been designed for robot endowed with poor sensors (a 16-element sonar array, a camera just performing very light computation, odometric sensors) which acts in an office-like environment. In the proposed landmark based approach, we have considered as "natural" environmental features the corners formed by wall intersections, and corners formed by doors that are present in the scene. The whole problem, from landmark recognition to position estimation, is carried out by a unified neurosymbolic system.


Sticks refer to snacks or cakes made of wheat flour, tapioca or sago flour, fat, eggs, and water. Sticks have a long flat shape processed with fried techniques, a savory taste, and a crisp texture. Sticks are made of raw materials and additional ingredients. The raw material is flour and is sometimes substituted by pumpkin flour. Pumpkin stick is alternative food to increase the production of pumpkin flour. This study aimed to determine the effects of using 10%, 20%, and 30% pumpkin flour on organoleptic properties (colors, smells, tastes, and textures) of sticks. This study employed an experimental design with a non-factorial completely randomized design (RAL) with three treatments and three repetitions. Moreover, 15 untrained panelists from Dayah Panjoe Village, Kuta Blang District, Bireuen Regency were involved to test the treatments. This study found that the highest nutritional value of the stick color was 3.64 (moderately liked by the panelists). The highest value of stick smell was 3.62 (moderately liked by the panelists). Meanwhile, the highest value of stick taste was 4.13 (liked by the panelists). Finally, the highest value of stick texture was 3.40 (moderately liked by the panelists). This research concluded that the substitution of 10%, 20%, and 30% pumpkin flour significantly affected organoleptic properties, such as color, smell, taste, and texture. This research suggests that further research measures the temperature of the frying pan and preferably greases the pumpkin flour with mashing.


The study examined the perception of job opportunities and entrepreneurial skills in library and information science. This study investigated librarians' perception of job opportunities and entrepreneurial skills in Library and Information Science LIS). Investigative survey design was adopted in which a sample of ten selected libraries in Kwara State using purposive sampling techniques was used. Data was collected using a self-designed questionnaire and data collected were analysed using frequency count and percentage. The findings showed that librarians are aware that there are entrepreneurial skills in LIS and majority has one or two LIS skills that can be used to become an entrepreneur but they are not informed on how to convert these skills to opportunity, they do not have the zeal for entrepreneurship and lack finance. The study recommended that parents should support and encourage their children to go into entrepreneurship after graduation and financial institutions, NGOs, and private sectors should offer free entrepreneurship training and create an avenue to financially support those who have interest in entrepreneurship.


North American bats are being decimated by White Nose Syndrome (WNS), a disease caused by the psychrophilic fungus Pseudogymnoascus destructans (P.d.). Bats are an important part of the ecosystem and have global economic impact through consuming insect pests or pollination of crops. Thus, we need to understand why some bat species are susceptible and some resistant to WNS to develop strategies to protect bats from this disease. However, WNS has decreased populations of some temperate bat species to levels where conducting research on live bats must be curtailed. We have generated transcriptomic profiles derived from primary wing fibroblast cell cultures of resistant and susceptible bat species that were exposed to P.d. Our data indicate that fibroblasts from susceptible species of bats have an enhanced immune response whereas the immune response in resistant species is muted. Importantly, these results were confirmed in samples collected from live bats prior to population declines. We have now developed qRT-PCR assays to test the activity of several immune genes that were upregulated in the cell-cultures (transcriptomics analysis). Generally, we found that wing tissue from tricolored bats (WNS-susceptible) late in hibernation showed increases in gene expression compared to pre-inoculation with Pd, but wing tissue from big brown bats (WNS-resistant) did not change (or decreased). These results, though preliminary, suggest that wing fibroblast cell-cultures may indeed be a good surrogate for using living bats in some kinds of WNS research. Our data also suggest that the cause for high mortality in WNS susceptible bat species is immune activation instead of immune tolerance.


A simple method is proposed to detect the number of change points in a sequence of independent exponential family random variables. An estimator to maximize some criterion, say SC(k), which is to maximize the log‐ likelihood function with some penalty term, is used in detection. Under some mild assumptions, the consistency of the estimator for the true number of change points and the boundedness between the estimated change locations and the true change location are obtained. Some simulated results are given, and the Nile problem is investigated by this method.


Experimental glomerulonephritis induced by heterologous GBM immunization in mice is temporarily prevented and reduced in severity when ATG is administered prior to or in conjunction with GBM. Once the disease is well established, ATG does not appear to significantly alter glomerular damage.


Salix anatolica J. Zieliński & D. Tomaszewski sp. nova (Salicaceae) from central Turkey is described and illustrated. It is compared with the two morphologically closest species, S. pedicellata and S. pseudomedemii.


Thermal aging embrittlement of newly developed W alloyed 9%Cr ferritic steel KA-STBA29/KA-STPA29 (ASME T92/P92) has been investigated. In order to clarify the controlling factor of the embrittlement, Charpy impact tests and determination of precipitates have been carried out using materials aged under various conditions. The decrease in the upper and lower shelf energies and the increase in the fracture appearance transition temperature (FATT) due to thermal aging were caused by the precipitation and coarsening of Laves phase. The decrease in the impact toughness was found to be uniquely correlated with the increase in the area fraction of Laves phase. In order to develop a non-destructive technique for detection of the thermal aging embrittlement, changes in electrochemical properties of KA-STBA29/KA STPA29 due to thermal aging have been investigated. The electrochemical polarization technique has been applied to thermally aged materials. Experimental results on electrochemical polarization measurements revealed that the peak current density "Ip" which appeared at a specific potential during potentiodynamic polarization measurements in 1N KOH solution linearly increased with the degree of embrittlement evaluated by the impact energy at 0°C. The increase in Ip corresponded to the increase in selective dissolution of Laves phase. As a consequence, the degree of thermal aging embrittlement can be estimated by the electrochemical technique.


Unmanned aerial vehicle (UAV)-enabled mobile edge computing (MEC) has recently emerged to provide services in the resource-shortage areas, e.g., rural and disaster rescue fields. However, to provide satisfactory services, especially for computation-intensive and time-sensitive tasks, UAVs are required to operate at their full capacity due to their limited computation resources. This may lead to excessive heat dissipation and damage computing units. To tackle this dilemma, this paper takes central processing unit (CPU) thermal constraints during UAV operating hours into consideration. To further relieve the burden on the UAV, we explore a hybrid MEC system with a base station and a hover-fly-hover UAV that is able to compute during flight. We aim to minimize the cruise duration of the UAV by jointly optimizing user admission policy, task scheduling, UAV hovering trajectory, traveling time, and computation-and-communication resource allocations. The formulated problem is complicated and we further divide it into four sub-problems which are alternating to be solved in sequence. Simulation results demonstrate that the proposed algorithm can achieve better performance than other baseline algorithms, and keep CPU temperature under control.


An expression for the grating growth rate in laser‐induced chemical vapor deposition is derived which incorporates the contribution from the plasmon field intensity. It is found that the ultimate grating height is independent of laser intensity, while the grating growth rate is linear in intensity. For the shallow grating case the expression reduces to exponential growth. Also discussed are several possible mechanisms which account for the periodic structure.


The widely present proteins in the natural environment interact with released nanoparticles, which changes the stability, transport, and fate of nanoparticles. Since proteins with different molecular weights contain various amino...


There is a need to develop an etching technology for the fabrication of nanostructures which provides accurate etch rate control at the atomic level, mask pattern transfer at the nanometer scale, and a clean damage‐free surface. In addition, it is highly desirable to integrate the etch with the growth so that in regrowth the problem of contamination is eliminated. Chemical beam etching inside a chemical beam growth system has a great potential of becoming such a dry etching technology. Etching at a subnanometer scale is conveniently monitored by using in situ reflection high energy electron diffraction. Unlike other dry etching methods, the only etching parameter that is critical for etch rate control is the gas flow rate. The etch rate varies linearly with the gas flow rate, which can be adjusted easily by well established mass flow technology. However, a surface roughening mechanism due to inadequate cation diffusion may change the initially two‐dimensional (2D) process into a three dimensional (3D) etc...


Polypropylene was grafted with dibutyl maleate and then used as interface modification agent to pre- pare composite material of polypropylene/CaCO_3.The influence of PP-g-DBM on the mechanical properties of the composite material was also discussed.The results showed that the impact strength,when CaCO_3 content being 30%,can reach to 6 kJ/m~2,which is 20% higher than that of raw polypropylene,while the disperse state of the discontinuous phase of CaCO_3 particles in PP matrix is significantly increased.


Objective To summarize the experience of surgery therapy of hydrocephalus caused by obstruction with neuroendoscope from 20 cases. Methods 17 cases with two-side type hydrocephalus was due to aqueduct obstruction ;3 cases with one-side type hydrocephalus was due to foramen of Monro obstruction. In 17 cases the neuroendoscpe was advanced into third ventricle via the frontal horn and foramen of Monro,and third ventriculostomy was performed to achieve free communication between third ventricle and interpeduncular cistern. Fenestration of pellucid septum was performed in 3 cases. Results All procedures were successful and the fistula was unobstructed. 17 cases with two-side type hydrocephalus was treated with third ventriculostomy.The results of 15 cases (88.2%) were satisfactory and 2 cases (11.8%) inefficient, then ventricle-peritoneal shunt with neuroendoscope was performed and the result of the another 3 cases with one-side type hydrocephalus were treated with fenestration of pellucid septum was satisfactory. The general effective rate was 90.0%. Conclusion Because of convenience, less wound and efficiency, the neuroendoscopic operation should be the first choice for the treatment of hydrocephalus caused by hydrocephalus aqueduct obstruction.


As the ever-increasing attention to green communication, energy efficiency has become an imperative metric in the emerging massive multiple-input multiple-output (MIMO) systems. In order to maximize the energy efficiency, transmit antenna selection has been widely concerned by researchers. In this paper, we investigate the coded cooperation transmission for dynamic transmit antennas aided two-hop massive MIMO systems. Explicitly, we propose a rate-less codes aided cooperation scheme for reducing the implementation complexity in the broadcast phase, compared to the fixed-rate coded cooperation scheme. Furthermore, we develop a partial cooperation scheme in the cooperative phase in order to avoid the low achievable rate caused by the full cooperation, especially when the source-to-relay (S-R) channels are poor. Finally, the number of transmit antennas at the base station (BS) is optimized through theoretical analysis in a metric of maximizing the energy efficiency. Moreover, we also analyze the achievable error performance for different modulations. Our simulation results demonstrate the effectiveness of the proposed scheme.


The radioactive explosion at the Chernobyl Nuclear Power Plant was one of the greatest anthropogenic disasters in history. The explosion took place on April 26th 1986 near Pripyat. Subsequently, radioactive dust was dispersed over long distances. As a result, a large area has been contaminated, including vegetation cover, which was analyzed in this study. The aim of the research was to explore plant condition near the town of Prypiat before and after the radioactive explosion in Chernobyl. Another goal was to estimate vegetation renewal after the disaster and changes in condition. Landsat TM images from five periods were used: 1984, 1986 (days after the explosion), 1987, 2002/2003 and 2010/2011. After preprocessing, vegetation indices have been calculated: NDVI, SAVI, ARVI, VARI, NDII and MSI. Because of cloud cover on the images, one area has been selected for detailed analysis. In addition, the meteorological conditions in each period have been analyzed. Two indices – NDVI and MSI have been chosen to present the results. The vegetation range and condition near Pripyat has changed after the disaster and at each subsequent date became better than earlier. The best plant condition was noted in 2010/2011, whereas the worst before the disaster – in 1984. For agricultural areas, the best condition was noted in 1986 and 2002/2003. Based on these studies there was no significant deterioration in the vegetation condition connected to the radioactive contamination. A more important factor was weather conditions. In fact, we can say that contamination has no influence on vegetation, the lack of human use of land on the other hand does.


Neralizea delayed Crowly Martin type predator prey systems with impulsive and harvesting terms were investiga ̄ ted. By using the ged continuation theorem and differential inequality skillsꎬ the existence of four positive periodic solutions were established for a delayed Crowly Martin type predator prey system with impulsive and harvesting terms. Moreoverꎬ an example was provided to illustrate the effectiveness of the proposed result. From multiple periodic solution of Crowly Martin type predator prey systems research processꎬ harvesting terms will affect the multiple periodic solution rule.


In recent times agile software development has evolved world widely with a huge impact. The major advantage of agile development is a faster development time with flexible structure that helps handling rapid changes to new requirements easily than the more rigid older processes. Although the agile approach is becoming popular, but it is reported to have certain disadvantages related to secure software development. For building a secure software, there is a need for security enhanced processes and practices. The growing trend towards using agile methods for developing the software and increase in security breaches over the last few years has concluded that it becomes essential to integrate existing high profile security engineering processes with agile processes. This paper is addressing this huge concern of security requirements for projects using agile development approach. It provides a framework to introduce security at process level with the help of fuzzy logic. This framework is implemented in Java language with user friendly graphical user interface. It uses a lightweight approach to add the security features by integrating security activities from Security engineering processes that too without compromising the agility of agile process.


A patient with acute sarcoidosis is described who presented with pleurisy and bilateral pleural effusions, but no other abnormalities on examination or chest X-ray. This presentation of sarcoidosis is unusual and is discussed.


The electrostatic force at head-disk interface (HDI) becomes increasingly significant when the head-disk clearance is dropping into 1 nm scheme. Therefore, detecting and eliminating the electric potential in the HDI is a critical task for hard disk drives. To that end, this paper proposed an in situ measurement method for electric potential at HDI using a thermal asperity (TA) sensor. When calibrating the electric potential, both dc and ac components of the external voltage were supplied to the disk. As a result, the output of the TA sensor to the first harmonic of the ac component was linearly increasing with the decrease in the dc components. Experimental results show that this method is more efficient and flexible than the traditional methods.


This paper presents a hybrid system controller design tool for finding stabilizing state feedback controllers for a class of switched system. The tool is based symbolic computation which avoids problems that may arise from rounding errors prevalent in numerical computation. Attention is focused on finding the existence of common Lyapunov function (CLFs), as this ensures stability for arbitrary switching sequences between subsystems. The switching system considered here is restricted to single input single output switching systems having second order linear subsystems.


Steady, incompressible, laminar boundary-layer flows over moving walls are numerically investigated with special regard to the MRS criterion for flow separation. To analyze separated flows without meeting any singularity at the separation point, a set of approximate equations (instead of the boundary-layer equations) is solved under the condition of prescribed external velocity distributions. Three different types of flows are considered, one of which is quite similar to that treated by Tsahalis. It is found that, at least for the flows treated in the present paper, the MRS criterion is not satisfied for the case of upstream-moving walls, although it is satisfied for the case of downstream-moving walls.


The title compound, C27H31N3O5, is also known as 13-oxofumitremorgin B. Intermolecular O—H⋯O and C—H⋯O hydrogen bonds stabilize the crystal structure.


In this paper,Zn-Ni complex nanowire was prepared by the electrospinning method.The samples were characterized by Differential thermal analysis(TG),scanning electron microscopy(SEM),transmission electron microscopy(TEM) and X-ray diffraction(XRD).The dielectric proprieties of the three phase composites composed of Zn-Ni complex nanowire、BT(barium titanate) and PVDF,were also studied.The results show that the diameter of nanowire precursor was about 500nm and the diameter of Zn-Ni complex nanowire was about 250nm.The dielectric property of Zn-NiO/(BT+PVDF) polymer composite is better than that of NiO/PVDF polymer composite and NiO/(BT+PVDF).


During software evolution, programmers add new functionalities and release new versions of software. This complicated work involves not only program development but also learning new knowledge. This paper explores an analogy between incremental program development and constructivist learning, and presents a case study that investigates this analogy. Four types of cognitive processes have been identified. They parallel analogous software engineering activities.


The solubilities of thiourea in pyridine, PEG-400, DMSO, and dioxane have been determined from 290.05 to 361.45 K by synthetic method. A solubility model is proposed and the solubilities calculated by the model show a good agreement with experimental data.


Contemporary popular discourses about Islam, shari'a and Islamic law in the West is often filled with the issues of terrorism, anti-democracy, human rights violation and women's minor status in Islam, which all lead into negative perception. Unlike such popular views, Western scholars perceive shari'a from various perspectives. They are quite critical to shari'a in a positive sense. This article discusses Western scholarly discourses on shari'a by comparing the thoughts and works of two most prominent figures, Wael B. Hallaq and M. Barry Hooker, who always concern with shari'a, Islamic law and related social issues, such modernity, colonialism and legal system. Based on the model of the study of public figure and grounded its main data on Hallaq's and Hooker's main work, this study shows that these two scholars promote idealistic and contextual perception on shari'a. From the ideal point of view, shari'a is seen a product of scholarly independent work by Muslim jurists, whose authority now is unfortunately taken over by the state. The contextual view regards shari'a as flexible Islamic religious or legal norms that are adaptable to the changing social and political environments so they are easily transferrable into the educational, legal and political system in a country like Indonesia, entailing what is called "national mazhab".


Algorithmic or automated decision-making has become commonplace, with firms implementing either rule-based or statistical models to determine whether or not to provide services to customers based on their past behaviors. Policy-makers are pressed to determine if and how to require firms to explain the decisions made by their algorithms, especially in cases where the algorithms are "unexplainable," or are equivalently subject to legal or commercial confidentiality restrictions or too complex for humans to understand. We study consumer responses to goal-oriented, or "teleological," explanations, which present the purpose or objective of the algorithm without revealing its mechanism, making them candidates for explaining decisions made by "unexplainable" algorithms. In a field experiment with a technology firm and several online lab experiments, we demonstrate the effectiveness of teleological explanations and identify conditions when teleological and mechanistic explanations can be equally satisfying. Participants perceive teleological explanations as fair, even though algorithms with a fair goal may employ an unfair mechanism. Our results show that firms may benefit by offering teleological explanations for unexplainable algorithm behavior. Regulators can mitigate possible risks by educating consumers about the potential disconnect between an algorithm's goal and its mechanism.


The main objective of my bachelor's thesis was to get familiar with the support possibilities intended for new entrepreneurs and also to figure out how well the service providers and their services are known among the new entrepreneurs and how those services have been utilized. It was also important to study how the support possibilities have affected new entrepreneurs and how aware the entrepreneurs are of those possibilities. The focus of the research was on the largest support providers which operate nationwide. The first part of the thesis' theory focuses on entrepreneurial background and business plan, which are essential factors considering the support possibilities. The second part focuses on the service providers and their services. The research was implemented as a qualitative research by interviewing new entrepreneurs in the Päijät – Häme region by phone. The interviews were based on a question frame which was prepared beforehand. Additional questions were asked, if the interviewees answers needed clarifications. 22 interviews were made for the study The findings of the thesis were based on the information about backgrounds of the interviewed entrepreneurs and how well the entrepreneurs knew about the services that the organizations provide and also how the businesses had exploited these opportunities. The conclusions were made by utilizing the background information of the entrepreneurs and by assembling similarities among the experiences of the entrepreneurs. The knowledge about the service providers among the interviewed entrepreneurs was good, yet the extent how the possibilities were utilized was relatively small. The reasons for that were related to the application processes which were considered troublesome, and also the quality of the information about the service was considered volatile. Subject headings, (keywords) entrepreneurship, business plan, qualitative resear ch, funding


To put the harmonious ideas into practice and to achieve the harmonious development in a university can not only achieve its self-development,but also make the university play a full role in the socialist society.The logic,based on the developing pattern of a university,the internal objective demand for the harmonious ideas and the practice of a university through the intrinsic link between the university and society,must be scientific,valuable,open and creative.


The current state of reliability specification and design methods is described. These methods aim to keep the expected value of the effect of network failures on the users under a certain level by assuming that the effect is approximately proportional to the outage time. The evaluation of long outages is discussed. Future reliability specification and design methods are also discussed.<<ETX>>


The synthesis and SAR of herbicidal N-substituted 2,6-bis(polyfluoromethyl)-1,2-dihydropyridine-3, 5-dicarboxylates are described. N-substituted dihydropyridines were readily prepared by treatment of the corresponding dihydropyridyl anions with electrophiles. Herbicidal activity of the N-substituted dihydropyridines is correlated with the rate of hydrolytic cleavage of the N-substituent to afford 2 or 3. Dihydropyridine 2 is shown to undergo oxidation in the soil to afford herbicidal 1, thereby relating the activity of N-substituted dihydropyridines to the corresponding aromatic herbicides.


The invention relates to a semiconductor device, a manufacturing method thereof and an electronic device. The method includes the following steps that: S1, a device wafer is provided, and silicon through holes are formed at the back surface of the device wafer, wherein the silicon through holes comprise conductive layers formed by a metal material; step S2, back portion grinding is performed on the device wafer until the tops of the silicon through holes are exposed, so that the thickness of the device wafer can be decreased; step S3, the back surface of the device wafer is etched, so that a part of the silicon through holes can be exposed; and step S4, etching back is performed on the exposed silicon through holes, so that the metal material left at the back surface of the device wafer and/or the surfaces of the silicon through holes can be removed. With the method provided by the invention adopted, the problem of the fragmentation of a dielectric layer in the prior art can be well solved, and the performance and yield of a device can be improved.


The first lidar in Earth orbit was recently flown aboard the Space Shuttle Discovery, September 9-20, 1994. The lidar In-space Technology Experiment (LITE) collected 45 hours of 3-wavelength atmospheric backscatter profiles during the 10-day mission. A wide variety of lidar measurements were made, including those of multi-level clouds, tropospheric and stratospheric aerosols, PBL heights, desert aerosols aloft, smoke from biomass burning, and pollution outflows from continents. This paper describes the LITE instrument and its capabilities, the worldwide correlative measurements program, and initial results.<<ETX>>


Blind identification of digital communication channels has attracted a significant amount of attention. In this work, subspace-based methods are considered specifically for direct-sequence/code-division multiple-access (DS/CDMA) signals in an asynchronous, multipath, multi-user environment. The objective is to reduce the complexity of previously proposed methods by exploiting the properties of DS/CDMA waveforms. In particular, knowledge of the DS/CDMA spreading codes is employed, via matched filtering, to reduce the dimensionality. The resulting algorithm shows negligible difference in performance with respect to a previously proposed algorithm by Torlak and Xu (see IEEE Trans. on Signal Processing, vol.45, no.1, p.137-47, 1997). However, the reduction in complexity can be significant. The Cramer-Rao lower bounds on the estimation variance are determined and provide further justification for the matched filtering scheme.


For many working to achieve sustainability over recent decades, it may appear the problem is well-known, and some partial solutions are well-known, but we can't get enough traction, synergy or leverage to make real change to human social, economic and environmental systems to actualize sustainability in the industrial nations. While it may have been easier and quicker to work on the "low hanging fruit" of change for sustainability (e.g., technical solutions, increasing efficiency, new light bulbs), this paper suggests the necessity of equal effort devoted to the "deep tangled roots" that extend down into the foundations of our academic disciplines and cultural mindsets. As I believe many would agree, our need for successful large scale change is urgent. This paper seeks to help clarify and integrate two major leverage points for systemic change–fundamental and dominant paradigms of life science and of economic systems–to help create sustainability in reality.


Irish higher education faces particular difficulties given the severity of its economic crisis. Like other countries, it is engaged in significant system restructuring coupled with managed policy direction. Where Ireland does differ is in its emphasis on a 'whole of country strategy' and commitment that teaching and research go hand-in-hand. This paper looks at the fortunes and mis-fortunes of Irish higher education.


By the growth of the Internet, the client's access to the Internet have been increasing. In order to meet those demands, asymmetric networks have become a great attraction. However, asymmetric networks composed of satellite and terrestrial links have not been enough investigated. Therefore, this paper proposes a new formula for TCP performance evaluation for the asymmetric networks. Using this evaluation formula, we calculate the throughput of TCP Reno over the asymmetric networks taking Slow Start into account. The calculation results are compared with the following: (1) the value based on an existing theoretical formula, (2) the outputs of simulation by NS (Network Simulator), and (3) the experimental results using VSAT (Very Small Aperture Terminal) satellite communication system for satellite links and the Internet for terrestrial links. As a result, it is shown that the new formula is more precise than the one already proposed. key words: TCP performance, asymmetric networks, satellite


The antioxidative activities of some typical natural and synthetic phenolic antioxidants,such as tea polyphenols,crnamic acid,vitamin E,butylated hydroxyl anisole(BHA) and butylated hydroxyl toluene(BHT),were calculated by B3LYP/6 -31G(d,p) method.The results indicated that the phenolic compounds which have electron-donating group at benzene ring and can form intramolecular hydrogen bonds possess higher antioxidant activity.From O-H bond dissociation energies(BDEs) the antioxidative activity of phenols is in the sequence of(-)-Epigallocatechin gallate(EGCG 292.74 kJ/mol) (-)-Epicatechin gallate(ECG 301.17 kJ/mol) Gallic acid(302.71 kJ/mol) BHT(304.60 kJ/ mol) BHA(313.54 kJ/mol) (-)-Epigallocatechin(EGC 310.16 kJ/mol) α -tocopherol(326.62 kJ/mol) Caffefic acid(327.34 kJ/mol) (-) -Epicatechin(EC 335.14 kJ/mol) Ferulic acid(339.09 kJ/mol) El-lagic acid(356.73 kJ/mol) VE(401.61 kJ/mol).Based on the difference of O—H BDE of phenols and C-H BDE of lipids,the effective antioxidants for unsaturated fatty acids were inferred.Epicatechin(EC),ellagic acid and feruluic acid could be used as effective antioxidants for unsaturated fatty acids containing only one double bond,whereas gallic acid,(-)-epigallocatechin gallate(EGCG),(-)-epicatechin gallate(ECG),epigallocatechin(EGC),α-tocopherol,caffefic acid,and synthetic antioxidants BHT and BHA,could be used for antioxidants of unsaturated fatty acids containing one or more double bonds.


By reading Faust through the lens of Goethe's own scientific principles, a new reading of the whole arises, a reading that revisits the historical debates about the conclusion of the play, whether about its morality, happy ending, or portrayal of technology. According to the naturalistic ethic that emerges within the text, the ending is tragic in that Faust ascends into a sphere characterized by stasis and non-productivity. The play thus is modern in its rejection of religious morality, while anti-modern in its critique of the scientist hero. (AOT)


This paper discusses the design of a concurrent simulation environment hosted on the Ada programming language at the Laboratory for Software Research at Texas A & M University. This environment was first implemented on a VAX 11/750 single processor system and then ported to a Sequent Balance 8000 parallel computer system with ten processors. Two run-time Ada systems were available on the Sequent: one for sequential and one for parallel. This paper reports our experiences in porting the original software to these new environments.


A web service is a piece of software exposed over the internet, which can use XML messaging system to communicate with other systems to carry out some kind of operation. The fascination of the mathematical community when it comes to utilizing the Web to facilitate the use of mathematics has lead to the development of mathematical Web services. Since mathematics is a structured domain, it needs to be defined and registered by its provider incorporating semantics, and afterwards discovered by service requesters. In this research work, discussed about the development of an interface that handles registration for the service providers named web service registration interface. It provides the capability for semantic description and registration while making use of an ontology tree to catalogue the characteristics of the mathematical web services, functional as well as non-functional. An XML file and a sorted file are used to store the registration details. The usability of user interface is analyzed and compared.


The angiotensin AT2-receptor (AT2R) and the receptor MAS both mediate very similar tissue-protective actions. Furthermore, AT2R-antagonists have been reported to block effects of the MAS-agonist Ang 1-7. Therefore we speculated that a molecular association between these two receptors exists resulting in functional interactions.
 Fluorescence resonance energy transfer (FRET) with photobleaching was used for detection of a putative interaction between MAS and AT2R in HEK-293 cells transfected with vectors encoding MAS or AT2R fused in the C-terminus with CFP or YFP. In addition, functional interaction of AT2R and MAS was assessed in primary mouse astrocytes by determining the effect of respective agonists and antagonists on expression of mRNA encoding the chemokine receptor CX3CR1.

 There was significant FRET efficiency of 10.8±0.8% when AT2-YFP and MAS-CFP were co-expressed indicating heterodimerisation. Both, MAS and AT2R also formed homodimers (FRET efficiencies: 7.4±0.8% or 9.2±0.8%, respectively). No FRET efficiency was observed with an unrelated transmembrane receptor, and expression of non-fluorescent MAS and AT2R competed with FRET efficiencies, which both supports specificity of receptor interactions. Regarding putative functional interactions, AT2R-agonist induced increases in CX3CR1 mRNA expression were absent in astrocytes concomitantly treated with the MAS-antagonists A-779 or in Mas-deficient cells. Likewise, effects of the Mas agonist Ang 1-7 were undetectable in cells concomitantly treated with the AT2-antagonist
 PD123319
 or in AT2-deficient cells.

 This study provides evidence that MAS and AT2 receptors form homo- and heterodimers. Heterodimerisation may be of functional relevance, because in primary mouse astrocytes, Mas and AT2 seemed only functional in the presence of the respective other receptor.


Multi phase fluids are common in energy-related geotechnical problems, including gas-water, gas-oil, ice-water, hydrate-water, and oil-water fluid conditions. The generalization of classical unsaturated soil mechanics concepts to energy geotechnology requires physical understanding of surface tension, contact angle, capillary pressure, solubility and nucleation. Eventually, these pore-level processes affect the granular skeleton. Together, pore and particle-scale interactions upscale through the sediment structure to affect its macroscale response. Possible emergent phenomena include fluid percolation, residual saturation and recovery efficiency; fluid driven fractures, lenses, fingering and pipe formation; bubble migration and bottom blow up. the other. The average residing time for a molecule at the surface of a liquid is in the order of 10 s (Shaw 1992). Interfacial phenomena are understood at the atomic level. The van der Waals force is the result of Coulombian interactions (Fig. 1a) between atoms or molecules that experience instantaneous polarization. A dipole experiences orientation polarization next to an ion (Fig. 1b); this situation is extended to the mutually induced rotation of two interacting dipoles (Keesom – Fig. 1c). An atom experiences displacement of the electron cloud relative to the nucleus in the vicinity of a charge or ion (Fig. 1d). Furthermore, a dipole may polarize an otherwise non polar molecule (Debye – Fig. 1e), and two non polar molecules may become mutually polarized because the instantaneous position of electrons confers an atom or molecule with some instantaneous polarity even when the time-averaged polarity is zero (London dispersion – Fig. 1f). The resultant Coulombian force for the instantaneous charge configuration shows mutual attraction in all these cases. The van der Waals force includes Debye, Keesom and London contributions (Fig. 1c, 1e, & 1f). The atomic analysis of van der Waals interactions helps explain surface tension and contact angle. (e) Dipole Polarized Molecule (Debye) (f) Two Polarized Molecule (London) (a) Ion Ion (Coulomb) (d) Ion Polarized Molecule


To study the long-term stability of the large-scale freezing project, the longest subway connecting channel constructed by the artificial freezing method in China is taken as the background. The uniaxial compressive strength test, triaxial shear test, and triaxial creep test of artificial frozen soil under different temperatures were carried out by using the MTS 370.25 mechanical testing machine. A series of triaxial creep tests for artificial frozen soil under different stresses and temperatures were carried out. Based on the creep test results, a fractional-order constitutive model of frozen silt with sand was proposed. Comparing the calculated results with the tested ones, it is found that the proposed fractional-order model can simulate the properties of frozen silt with sand very well. Compared with the other creep models of frozen soil, the proposed model here has higher accuracy and strong stress sensitivity. Through the simulation of the connecting channel construction and comparison with the observed data in site, the effectiveness of the model is verified, which further verifies that the model has important guiding significance for the freezing project.


THE region which surrounds Lake Champlain presents a very great variety in its surface features. As the tourist sails through the lake he may see, here lowlands, there mountains; on the one hand rocky hillsides, on the other meadows or marshes; here boundless forests, there wide and sparsely timbered plains, the whole intersected by numerous large streams and in the midst the lake itself, its northern portion filled with large islands, while south of these is open water. Such a territory must, if we can judge, have offered very great attractions to those savage tribes of red men who, in the early days before the white men began to encroach upon the lands they called their own, roamed through the forests or glided in their canoes over the water, for here they would find hunting grounds occupied by a great variety of game, surrounding fishing grounds of equal richness, fertile fields for the cultivation of the few vegetables which they used, and many a wild retreat in which they could conceal themselves from any p werful foe who should attack and defeat them. In such a region we should expect to discover many a site of an ancient village and great numbers of those stone implements which indicate the former presence of those who made and used them. We do not, however, find these expectations filly realized, for remains of ancient settlements are very rare, and no sure evidence exists of any long continued occupation of any locality in the immediate vicinity of the lake, and if a considerable population, with fixed settlements, ever lived there, it was long before the advent of the early explorers. In the writings of Champlain and others, we find intimations, in the quoted statements of the sav-


The formation of thin films of 3-glycidoxypropyltrimethoxysilane (GPS) on gold was studied by reflection-absorption infrared spectroscopy (RAIR) and optical ellipsometry. Mass changes on the surface were measured with the quartz crystal microbalance (QCM). Thin films of poly(ethy1enimine) (PEI) were formed on these modified gold surfaces and crosslinked with the diepoxy compound EPON (bisphenol Nepichlorohydrin epoxy resin). The resulting films are reactive toward HSiClMeZ. The expected substitution of chloride a t the silicon center is observed, showing that amino andor oxo ligands are available on the surface. The stability of the PEIIEPON films in water a t different pH and temperatures was studied by electrochemical methods and compared to that of monolayers of octadecylmercaptan (ODM) and octadecyltrichlorosilane (OTS). ODM on gold is quite stable a t neutral and basic pH in aqueous solution up to 100 "C. Films of PEI, covalently bonded to the GPS layer and cross-linked with EPON, are extremely durable. The drastically reduced Faradaic response of these films is consistent with a continuous coating. The films withstand temperatures in the range of 25-100 "C at pH 6 and 9 for several hours. These films show promise for applications as barrier coatings and thermostable reactive interfaces.


While there are limited vaccine to prevent the coronavirus disease, chairperson of the Commission on Higher Education (CHED) also asked students and personnel to strictly follow recommended preventive actions to avoid being exposed to the virus and to prevent its spread, such as avoiding close contact with people who are sick, staying home when sick, covering mouth and nose when sneezing, cleaning and disinfecting frequently used objects, and sanitizing hands regularly. The CHED chairman added that tertiary institutions must ensure that there are adequate safeguards within the campus such as hand sanitizers and information tools such as tarpaulins showing preventive measures to take against the disease. This study specifically, intends to describe the level of responsiveness of Laguna State Polytechnic University (LSPU) in coronavirus (COVID -19) pandemic which includes: the planning phase, enhanced communication due to reports of effective human-to-human disease transmission, social distancing, pandemic period, and management of pandemic cases. Also, this research tends to develop a resulting plan outlines departments, activities, and resources that are necessity in the milestone decisions. This research also undertakes the important task of measuring the economic and social importance of different social distancing and pharmaceutical interventions that are normally adopted by the public health officials and private citizens in an effort to fight COVID-19 pandemic. These interventions may include social distancing, a prioritized governmental distribution of vaccines and antiviral medications, and pharmaceutical consumption in the private sector. Individuals may possess strong private incentives to avoid the disease, and are willing to self- impose social distancing measures. Traditional models in epidemiology and economics focus on the prevalence of the disease. Result of this study showed that LSPU promptly responded to the pandemic by going online. In record time, the administrators, staff, as well as the students moved from physical spaces that provided them with much social interactions. LSPU shift to online platforms happened and mainly driven by the academic needs of the whole academic community and had digital learning platforms in place, and the means to operate, for the continuous education of the students. As the situation continuous to develop, the administrators are taking active role in addressing both the immediate and long-term challenges related to the outbreak. The LSPU community initializing to help students with lack of access to internet connection by proving E-Bus that are deployed to different part of the community.


Note: titre Anglais: The State and the new information and communication technologies Reference MIR-CHAPTER-2005-018 Record created on 2005-10-12, modified on 2017-09-01


To aid the productive sector becoming professional in the dairy activity, Avipal Alimentos S.A. implemented the Benchmarking System, which served as strategy to improve the technical and economical acting of the Units Producing of the State of Rio Grande do Sul. Like this, the present work has as objective evaluates the evolution of the coefficients of technical and economical acting of the benchmark producing units that participated in the three periods of analysis of the benchmarking system. For so much, a study of descriptive and exploratory character was accomplished, which made possible to evaluate the pertinence and the effects of that technique on the dairy activity primary section. After that evaluation, it was concluded that the benchmarking technique has been exercising a fundamental paper for the to make decision process and administration of the producing units. That technique has been aiding the benchmark producers to measure the degree of efficiency of the dairy activity, as well as to detect the weak points of the productive system. Besides, the popularization of the information obtained through the identification of the benchmark producing units, it can aid the others involved with the productive chain of the milk address their competences for the invigoration of the activities carried out by the productive sector.


Nepali society is highly stratified with many glaring inequalities among different socioeconomic groups. The worst positioned among them are Dalits. The caste system segregates Dalits from the rest to such an extent that they are denied basic human rights. Tracing exclusionary practices in Nepal, it is clear that firstly the spatial exclusion is reflected through disparities in development levels owing to the remoteness and location specific characteristics. Secondly, gender-based exclusion is manifested in poor development indicators for women and thirdly the caste/ethnicity-based exclusion of specific castes, communities, indigenous people and nationalities leading to low level of development achievements.


Oncotype DX recurrence score is used to categorize oestrogen receptor positive, human epidermal growth factor receptor-2 negative , lymph node negative early breast cancer in to high- or low recurrence risk groups . It has a guiding significance for whether post-operative chemotherapy should be indicated or only hormonal manipulation is selected as an adjuvant treatment. Aims Assess the impact of Oncotype DX recurrence score on the adjuvant chemotherapy related management decision making in cases of ER+ve,HER2-ve,LN-ve early breast cancer in our local unit. Material and methods A cohort of 76 patients with early breast cancer included, two had bilateral disease. All has been operated for oestrogen receptor positive , human epidermal growth factor receptor-2 negative, lymph node negative early breast cancer. Tumour grade,Ki67 proliferative index, PREDICT and Oncotype DX recurrence score results obtained in addition to offered treatment information for each case. Results After tumour primary surgery and Oncotype DX recurrence score assessment , 18 patients(24%) were eligible to adjuvant chemotherapy , out of them ,10 patients (56%) has a chemotherapy absolute survival benefit of > 15% at 10 years ,where 5 patients (30%) has a chemotherapy relative survival benefit of ~ 6.5% ,3 patients (17%) has a chemotherapy relative survival benefit of ~1.6%. In this cohort, ten patients (13%) had low Oncotype DX recurrence score, however have had adjuvant chemotherapy based on other clinico-biological parameters. The other 48 (63%) patients with a low recurrence risk had been spared from the potential adverse events related to the systemic therapy. Based on the menopausal status, every patient had received the suitable hormonal manipulation therapy . The data also revealed absence of relationship between Ki67 proliferative index and the Oncotype DX recurrence score (P=0.06), also tumour size do not correlate with Oncotype DX recurrence score (P=0.5). Conclusion Oncotype DX recurrence score provides a credible prediction of distant disease recurrence risk in early breast cancer, however doesn't correlate with other prognostic markers as Ki67 proliferative index as well as tumour size. In this cohort, the use of Oncotype DX recurrence score testing led to a 24% rate of treatment decision recommendations in the direction of adjuvant chemotherapy in addition to anti-hormonal therapy for oestrogen receptor positive, human epidermal growth factor receptor-2 negative , lymph node negative early breast cancer.


Macrophages are a key cellular component of the immune system. In the body they act as front line immune defense and are vital chemical factories that respond to their environment by secreting various chemical mediators. A complete understanding of the molecular details of phagocytotic process and macrophages ability to modulate the signaling activity is still lacking. In the present thesis we designed and used novel nano-materials to understand and modulate macrophage behavior. In order to decipher the cell mechanics and signaling occurring during phagocytotic uptake, we used hollow polyelectrolyte capsules as force sensors. In order to enumerate the forces from the deformations, the capsules were calibrated and a stiffness of 0.11 ± 0.02 nN/nm was found. Using a swept field confocal microscope, we could follow the deformations occurring on the capsule during the phagocytotic uptake. This allowed us for the first time to decipher the mechanics of phagocytosis uptake in its natural state without applying any external mechanical forces or perturbing the cells. It was observed that macrophages during the retraction phase of the uptake, buckled or irreversibly deformed the capsules. From the mechanical characterization, we know that it takes 150 nN to buckle the capsules, this upper limit of the "PhagoSensor" approach is thirty fold higher than the values previously measured by other techniques. To systematically decipher the mechanistic roles of individual molecules in phagocytotic cup formation, we inhibited key signaling molecules PI3-Kinase and SYK, the eccentricity of the deformed capsules was found to be 0.87 ± 0.05 and 0.75 ± 0.05 respectively. This showed that the activation occurs in a sequence. In the second part of the thesis, new implant surfaces were designed for people having a propensity for chronic inflammation. These engineered surfaces can modulate and make macrophages secrete anti-inflammation cytokines. The surfaces comprised of nanopatterned substrates with regular hexagonal spacing of 36, 63, 80 and 125 nm, decorated with Fc fragments. There was a modulation in cell area and cytokine production on the nanopatterns. It was found that the Fc nanopatterns were superior in eliciting anti-inflammation response (TGF-s & IL-10) than random presentation of Fc fragments. We found that the anti-inflammation effect starts after 24 hrs and at 48 hrs we could see reduced pro-inflammation. Comparing the pro- and anti-inflammatory cytokine production, it was concluded that 36 nm spaced patterns are ideal for eliciting cytokine mediated anti-inflammation signaling. To include both the beneficial effects of polymer surfaces and nanopatterning, a new protein nanopatterning approach for thermochemical nanolithography (TCNL) was developed. This technique can generate high-resolution, multi-protein patterns in arbitrary shapes on polymer substrates. TCNL uses a resistively heated AFM tip to unmask amine groups. We modified the micro and nano patterns generated to include different chemical functionalities and thereby allowing us to bind multiple proteins on the same substrate in different shapes. Several approaches have been developed to immobilize proteins and other biomolecules like DNA onto these templates. These templates are stable and can be stored for later bio-functionalization for at least 4-6 weeks. A strategy to prevent protein adsorption on the surfaces was developed. It was demonstrated that these passivated surfaces reduced the non-specific binding of proteins by approximately 20 times. Finally, the bioactivity of the patterned proteins was demonstrated using an in-vitro protein assay and in-vivo cell assay.


The Department for Work and Pensions has launched a social networking website akin to Facebook and Myspace to enable the over-50s to communicate with the government and each other about issues that concern them. The site, www.generationxperience.wordpress.com , is a pilot scheme.


Marine scavenging lysianassid amphipods depend on chemoreception for detecting car- rion, a scarce resource, efficiently. This study focused on the chemoreceptive foraging of the scaveng- ing amphipod Scopelocheirus onagawae using bioassay. Among the extracted fraction from flounder muscle, neutral and basic amino acids, especially glycine (Gly), alanine (Ala), and arginine (Arg), which are abundant in the tissues of marine animals, showed highly stimulatory effects. Synergism, the enhancement of the stimulatory efficiency by acidic amino acids (e.g. aspartic acid; Asp) that have minimal attractive effects as individual amino acids, was also observed. The threshold concen- tration of amino acids leading to a locomotory response was 10 -7 mol l -1 , which is relatively low among crustaceans. The locomotory response at the threshold became more sensitive when amphipods were acclimatised to a lower concentration of amino acids (8.0 × 10 -8 M), suggesting that sensory adaptation is involved in their foraging. The chemoreceptive system in S. onagawae, i.e. the detection of common chemicals from animal tissue as feeding stimuli at low threshold concentrations, is advantageous in detecting a wide range of carrion prey items from a broad area. The high sensitiv- ity, sensory adaptation and synergism by uncommon amino acids would be a beneficial adaptation for discriminating a food odour in an environment of chemical 'noise'. Since S. onagawae is a noctur- nal suprabenthic forager, the sensitive chemoreceptive ability found in this study would be adaptive for detecting sparse and limited carrion items, the odour plume of which can reach their swimming layer, suggesting that this species is a specialised carrion feeder.


With the continuous development of Web front-ends, Web pages have become more and more complex, and strong interactivity has brought about the skyrocketing of page status, and more and more DOM operations are used to update pages. However, frequent DOM operations make page rendering slow and cause front-end performance bottlenecks. In view of the low performance of the Web front-end, we analyze and summarize the B/S architecture principles from the back-end to the front-end of the Web, browser caching, browser loading methods, server configuration related to HTTP, and other processes that affect the front-end performance optimization. Factors, systematically propose a complete Web front-end performance optimization solution designed to improve web page loading speed, rendering speed and user experience, with strong integrity and versatility. In order to effectively reduce the waiting time of users, a calculation model of connection request scheduling weight is proposed, and a request scheduling algorithm SACC is proposed on the basis of this model. Experiments have proved that the algorithm can effectively reduce the TDD and TSR indicators of web pages. In the experimental platform IE7, the average reduction rate is 13% and 25% respectively.


Review(s) of: Reality TV: Remaking Television Culture, 2nd Ed., by Murray, Susan, and Ouellette, Laurie (eds), New York University Press, New York, 2009, ISBN 9780814757345, ix+377 pp., A$49.95. Distributor: Footprint Books.


Purpose: This study investigated perception and plan of dental technologists regarding the old age and retirement for them to enjoy stable old age. Methods: Dental technologists working in Seoul, Incheon, and Gyeonggido were asked to fill out a self-administered questionnaire, and a total of 200 copies were used for analysis. The collected data were statistically analyzed by using SPSS 22.0(Statistical Package for Social Sciences. Chicago, IL, USA) (a=0.05). In order to compare perception toward old age preparation among the subjects, a Chi-square test was performed, and, to investigate the level of preparedness for old age according to general characteristics, t-test was performed. Results: In the analysis of the old age preparedness by age, there was a significant difference in financial preparation, Asset identification, use of retiring allowance, information gathering, senior town home, and stability (p<0.05). To the questions regarding perception toward retirement, the majority of the subjects (60.5%) answered they had thought about retirement, and many (23.9%) of them the reason to job stress (23.9%). Regarding old age preparedness according to workplace, there was a significant difference in use of retirement allowance and education for old age preparedness between general dental laboratories and general hospitals (p<0.05). Conclusion: It is believed that, for preparation of dental technologists for stable old age, in addition to their personal effort, it is important to provide social support and practical measures to ensure welfare and retirement.


Abstract The electrovortex movement of liquid metal in a direct current arc furnace with a bottom electrode under its own electromagnetic field has been investigated. The physical and mathematical formulations of the processes are given. The algorithm of a solution was developed and the method and software packages for modelling the processes were chosen. The results of electromagnetic and magnetohydrodynamic field analyses in the industrial furnace are given. The verification of results has been done by comparing them with general electrovortex movement theory, experimental data and results of similar software packages.


Assessment of liver function Confirmation and identification of the position of gastro-epiploic vessels during minimally invasive esophagectomy Delineation of the ureters during laparoscopy Detection and resection of colorectal neoplasia Detection of ovarian cancer metastases Detection of tumor angiogenesis and monitoring of response to anti-tumor vasculature therapy Diagnosis of peripheral artery disease Diagnosis of rheumatoid arthritis Evaluation of coronary atherosclerosis Evaluation of soft tissue viability to guide debridement in trauma surgery


The technic we use in this hospital in the preparation of the blood serum culture media does not vary from that given in text-books, except in one particular. At the time of coagulation we place the tubes on a rack which we have devised, which is so designed that it will fit in any medium-sized Bausch and Lomb hot air sterilizer, thus giving better results. It will not be amiss, however, briefly to recapitulate the technic. Blood from the bullock, killed preferably by the Jewish method, is received in a clean gallon bottle. The bottle is then placed in the refrigerator and allowed to stand for twenty-four hours, thus allowing the blood to clot firmly. The serum is pipetted off, care being taken not to break the clot, thus keeping the serum as clear as possible. The serum is then taken and


The present invention pertains to a system and method for monitoring an analyte. Extreme point information, which is information pertaining to an arrival time at which a time series of measurement signals from a measuring means (12) reaches an extreme point, is calculated for respective subjects. At least one time slot in a day is determined to be a time slot of interest (100, 102, 104) close to the arrival time on the basis of the acquired extreme-point information. A sampling interval (T) at the time slots of interest (100, 102, 104) thus determined is set successively.


In the simulation software DYNAFORM, regarding the computation model of the drawbead restraining force established in the text "drawbead binding model and experimental study" as an equivalent drawbead, simulating and analyzing the forming of a certain component on the base of the surface dial. The results show when analyzing wrinkling and fracture, the computation model of the drawbead restraining force established in the text is closer to the result of using real drawbead restraining simulation Than using equivalent drawbead in DYNAFORM.


Background: Janus kinases (JAKs), including JAK1 and JAK2, mediate the signaling of cytokines and growth factors implicated in the pathogenesis of myelofibrosis (MF). Suppression of JAK2 leads to cytopenias due to its involvement in the signaling pathways of thrombopoietin and erythropoietin.

Purpose: The objective of this ongoing study is to evaluate the efficacy and safety of INCB039110, a selective JAK1 inhibitor, in patients with MF with the goal of improving MF-related symptoms with less myelosuppression than seen with JAK1/JAK2 inhibition. Here, we report the 12- and 24-week efficacy and safety of INCB039110 in a phase II trial.

Methods: Adults with intermediate-1 or higher (per Dynamic International Prognostic Scoring System [DIPSS]) primary MF (PMF), post–polycythemia vera MF (PPV-MF), or post–essential thrombocythemia MF (PET-MF) were eligible regardless of JAK2 V617F mutation status. A platelet count of ≥ 50 × 109/L, hemoglobin ≥ 8.0 g/dL (transfusions permitted), and a palpable spleen or prior splenectomy were required.

Patients assessed the severity of 19 disease-related symptoms daily using the modified Myelofibrosis Symptom Assessment Form v3.0 electronic diary. Spleen volume (SV) was evaluated by magnetic resonance imaging or computed tomography at baseline, week 12, and week 24. The primary endpoint was the proportion of patients with a ≥ 50% reduction from baseline in total symptom score (TSS, consisting of the sum of 6 individual symptom scores: night sweats, itchiness, abdominal discomfort, pain under left ribs, early satiety, and bone/muscle pain) at week 12. Other endpoints included the proportion of patients with a ≥ 50% reduction from baseline in TSS at week 24, percentage change from baseline in TSS at week 12 and 24, percentage change from baseline in SV at week 12 and 24, and safety.

The study used a Simon 2-stage design to assess 3 separate dose cohorts (100 mg twice daily [BID], 200 mg BID, and 600 mg once daily [QD]). A dose cohort could be expanded if ≥ 3 of the first 10 patients met the primary endpoint (intent-to-treat method).

Results: Enrollment is complete and 87 patients have been treated with INCB039110: 10 in the 100 mg BID, 45 in the 200 mg BID, and 32 in the 600 mg QD groups; 10, 42, and 31 patients, respectively, were evaluable for the primary endpoint. The 200 mg BID and 600 mg QD cohorts met criteria for expansion.

Enrolled patients (mean age, 64 years) had PMF (55%), PPV-MF (26%), or PET-MF (18%), and most had intermediate-1 (37%) or intermediate-2 (47%) risk by DIPSS. Mean SV at baseline was 2442.7 cm3, mean hemoglobin was 10.2 g/dL, and mean platelet count was 246.7 × 109/L.

Reductions in TSS were similar between the 200 mg BID and 600 mg QD groups, and largely maintained through week 24 (Table). Modest reductions in spleen volume were attained in the 200 mg BID and 600 mg QD groups.

| | INCB039110 Dose |
||
| 100 mg BID | 200 mg BID | 600 mg QD |
| Patients with ≥ 50% improvement in TSS,* n/N (%) |
| Week 12 | 2/10 (20) | 15/42 (36) | 10/31 (32) |
| Week 24 | 2/10 (20) | 12/42 (29) | 11/31 (35) |
| Median change from baseline in TSS,† % |
| Week 12 | −28.5 | −45.8 | −37.2 |
| Week 24 | −57.2 | −48.6 | −46.7 |
| Median change in SV,† % | | | |
| Week 12 | −0.5 | −14.1 | −14.5 |
| Week 24 | −31.1 | −17.4 | −17.1 |
| * Patients who discontinued prior to the week 12 or 24 visit were considered nonresponders at that time point. † Only patients with baseline and week 12 or 24 data were included. Negative change = improvement. |

Table

Mean platelet count is shown in [Figure 1][1]. Mean hemoglobin levels in patients who entered the study without transfusion requirements and did not receive post-baseline blood transfusions are shown in [Figure 2][2]. In these patients, the mean percent change from baseline in hemoglobin at week 24 increased by 5.6% in the 200 mg BID group and 8.6% in the 600 mg QD group.

The most common nonhematologic adverse events (occurring in > 15% of enrolled patients overall regardless of causality) were fatigue (29%), nausea (21%), upper respiratory tract infection (18%), constipation (17%), diarrhea (17%), and cough (16%); most of these events were grade 1 or 2 and did not appear to be dose dependent. New or worsening grade 3 or 4 anemia occurred in 33% and 0% of patients, respectively, and thrombocytopenia in 24% and 5% of patients, respectively.

Conclusions: Patients with MF treated with the JAK1 inhibitor INCB039110 (200 mg BID or 600 mg QD) continued to show meaningful improvements in MF-related symptoms and modest decreases in spleen size, while preserving mean hemoglobin levels over time through week 24.

![Figure 1][3]

Figure 1

![Figure 2][3]

Figure 2

Disclosures Mascarenhas: Incyte Corporation: Consultancy. Talpaz: ARIAD, BMS, Sanofi. Incyte, Pfizer: Research Funding. Gupta: Novartis: Consultancy, Honoraria, Research Funding; Incyte Corporation: Consultancy, Research Funding. Foltz: Novartis: Consultancy, Honoraria, Research Funding; Incyte Corporation: Research Funding; Gilead: Research Funding; Promedior: Research Funding; Janssen: Consultancy. Savona: Karyopharm: Consultancy, Equity Ownership, Membership on an entity's Board of Directors or advisory committees; Gilead : Membership on an entity's Board of Directors or advisory committees; Incyte Corporation: Membership on an entity's Board of Directors or advisory committees; Celgene : Membership on an entity's Board of Directors or advisory committees. Paquette: Incyte Corporation: Speakers Bureau. Coughlin: Bayer: Honoraria, Membership on an entity's Board of Directors or advisory committees; Amgen: Honoraria, Membership on an entity's Board of Directors or advisory committees; Eastern Health: Employment. Winton: Incyte Corporation: Membership on an entity's Board of Directors or advisory committees, Research Funding. Hunter: Incyte Corporation: Employment. Assad: Incyte Corporation: Employment. Clark: Incyte Corporation: Employment. O'Neill: Incyte Corporation: Employment. Hoffman: All Cells LLC: Consultancy, Membership on an entity's Board of Directors or advisory committees; Geron: Consultancy, Membership on an entity's Board of Directors or advisory committees. Verstovsek: Incyte Corporation: Research Funding.

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Considering the limits of existing authority management of Information Systems, a new management scheme is put forward in this paper, which is a dual control scheme for authority management from two different perspectives: database perspective and application system perspective. It comprehensively uses two authority mod- els: "user/role/authority" model and "user/authority" model. This scheme, which is flexible, enhances the security of the systems, and has been proved to be efficient in practical applications.


This paper reports on the San Rafael Swell Wilderness Study areas, which includes the Muddy Creek, Crack Canyon, San Rafael Reef, Mexican Mountain, and Sids Mountain Wilderness Study Areas, in Emery County, south-central Utah. Within and near the Crack Canyon Wilderness Study Area are identified subeconomic uranium and vanadium resources. Within the Carmel Formation are inferred subeconomic resources of gypsum in the Muddy Creek, San Rafael Reef, and Sids Mountain Wilderness Study Areas. Other commodities evaluated include geothermal energy, gypsum, limestone, oil and gas, sand and gravel, sandstone, semiprecious gemstones, sulfur petrified wood, and tar sand.