In this paper, the author deals with the results on perception of desirability of preserving the cultural diversity. The matter of diversity surpasses the conjuncture of the subject and reaches for the anthropological aspects of the human species and its perspective. The author problematizes the questions on homogenization and cultural diversity by pointing out the presence of two tendencies in this globalization times: on the one hand, there is a process of civilizational homogenization which leads into imperial hegemony of a single model relying on the military sector and global expansions of cultural industry products via mass media, while on the other hand, one can feel the repulse to the loss of cultural diversity in the world. The cultural diversity comprises different cultural and historical experiences that can contribute to the making of paralel development patterns. This paper is also an analysis of the empirical research on the corresponding sample ( 2007; N= 189) at the Academy of Fine Arts, at the Faculty of Mechanical Engineering and Naval Architecture and nt the Faculty of Philosophy). In the analysis there were used the univarinte, bivariate and multivariate statistics techniques (componential analysis under the G- K criterion as well as the variance analysis). The results have shown that the majority of the examinees (87% to 96%) supports the cultural diversity in the world, while the same percentage does not accept the idea of «the unique culture in the world». Three factors were extracted, respectively: «Accepting the cultural diversity». «Accepting the modern culture» and «Cultures with No Prospects». The variance analysis on variables and factors has shown that there were significant differences between the groups, depending upon the examinees features and attitudes. Among the persons questioned, the female examinees, the Faculty of Philosophy students, religious and left-oriented examinees seem to be significatly more apt to the cultural diversity. In bigger number of variables there were not determined statistically significant differences.


Objective To study the application of ultrasound diagnosis of various brain injury caused by hypoxic-ischemic encephalopathy(HIE).Methods The cranial ultrasonic image of 37 term infants with HIE and 15 preterm infants with asphyxia were recorded,and the exam through prefonticulus in coronal plane and sagittal plane were taken.Results Term infants with brain injury in earlier period mainly had cerebral edema,while preterm infants mainly had cerebral white matter injuries;term infants with intracrinial hemorrhage mainly presented as hemorrhage in choroid plexus while preterm infants mainly presented as subependymal hemorrhage.Brain injury in late period term infants mainly had cystoid alteration and atrophy in brain substance while preterm infants had mainly white matter malacia surrounding the brain ventricle.Conclusion①Cranial ultrasound could reflect the site and type of brain injury in HIE,and could observe the developing process of brain injury dynamically.②Brain atrophy,intracranial cystoid alteration,obstructive hydrocephalus after intracranial hemorrhage,and paraventricle white matter malacia in the image of HIE patients indicate bad sequela.


The eating-house was a pillar of late nineteenth-century American cities, feeding famished industrial workers and harried professionals. Urban wage laborers came to depend on cheap lunch joints for a quick midday meal, in the process altering Americans' relationship with food. Eating-houses familiarized many Americans with the habit of purchasing cooked meals, eating rapidly with strangers, and the increasing distance between diner and farmer. The beef-centric meals served at such establishments helped strengthen the nationwide network of industrial ranching. This prose piece explores the experience of dining in an eating-house from the perspective of a hungry laborer.


The objective of the present work was to evaluate the changes in morphological and physicochemical characteristics of Moroccan prickly pear cultivars at three different stages of maturity. The results of morphological study showed that the width, length, skin thickness, diameter and depth of receptacle differed significantly depending the cultivars and did not differ significantly depending the maturity. Other parameters such as the weight of the pulp, the skin and the whole fruit differed significantly depending on the cultivars and the maturity; they increased with advance in maturity, while the proportions of skin decreased.
For the physicochemical analyzes, the results showed that moisture, pH, Brix, vitamin C, total sugar and fat have a significant difference between the cultivars and maturity; they increased with advance in maturity, while the percentage of fat decreased. However, no important differences were observed in ash, reducing and non -reducing sugars between the stages of ripeness of the fruits.


FOR SOME TIME now we apparently have been bumping along the bottom of the depression, perhaps starting the climb to another period of prosperity. It seems to be agreed that one need we face, if that climb is to take place, is greater efficiency in marketing. The costs of marketing are believed to be much too great. An important factor in these costs is the expense of personal selling. How can this expense be reduced? Scientific management in this field would seem to be vitally necessary. Various studies by authorities indicate that successful concerns have used methods which can be summarized as follows: All possible sources of recruits are drawn upon for salesmen. The principal ones of these sources are a concern's other departments, the staffs of competitors, salesmen from related and non-related lines, non-salesmen from outside the business, college and high school graduates, and casual applicants. These sources are tapped by recourse to advertising, recommendations of employees and customers, schools and colleges, employment agencies, and unsolicited applications. The sources are then analyzed so as to reveal the ones from which the most successful salesmen come, and only the best sources are used thereafter. In selecting salesmen analyses are made to discover the qualifications a salesman should possess to sell the line of goods in question. After these are worked out, a procedure is developed for discovering which applicants possess them in a degree sufficient to make for successful selling. The procedure most commonly used consists of a preliminary interview in connection with which a rating scale is used, followed by the filing of a detailed application blank properly filled in and the obtaining of reports from previous employers. The documents are studied carefully, and a further interview is held to eliminate differences between the rating they yield and the interview rating. In addition, some concerns try to discover the type and degree of intelligence desirable in handling a particular product and the prevailing type of customer and to test the applicants accordingly. Some aptitude tests have been devised by psychologists; but these are not used widely as yet. As an important aid to selling, equipment needed to tell the sales story and to show the products properly is provided. This involves an .analysis of samples and other presentations of products to show what makes the most favorable impression. Then there is need to keep the materials fresh looking and clean. Training is accomplished by means of an adequate course of instruction based upon job analyses and the intelligence and previous education of the prospective salesman. These courses of instruction comprise a study of the following subjects: principles of salesmanship, psychology of selling, problem analysis, products and markets of the concern, its history, and its business policies. The instruction is given in classes, individually, by correspondence, and by supervision during the first few months the salesmen is in the field. The instruction extends over several months, possibly over two years. Control of salesmen is affected by establishing quotas based on a scientific analysis of the trading areas covered, just allocations of territory, and daily .and weekly reports of salesmen's activities and expenses. These reports are carefully studied and analyzed in relation to sales made. Compensation is based on the principle of providing the greatest possible incentive to the salesman to put forth his best efforts


Estimation of the risk under the accident that hexamethylenetetramine flows out to the river due to a direct earthquake S. HAMAMOTO1*, L. ITO1, N. YONEYAMA2, A. TOKAI1 1Osaka University, Division of Sustainable Energy and Environmetal Engineering, Graduate school of Engineering, 2-1 Yamadaoka, Suita, Osaka, Japan 2Disaster Prevention Research Institute, Kyoto University, Research Center for Fluvival and Coastal Disaster,Gokasho, Uji, Kyoto, Japan (*correspondence: email@example.com)


Objective: To reflect on nursing care in care of the skin premature, based on the analysis of national and international scientific literature on this topic and discuss the benefits and harms of this care. Methods: This is a literature review on nursing care in care of the skin premature newborn. Data were published over the last ten years in the databases: MEDLINE, LILACS and BDENF. We adopted the thematic content analysis method. Results: We derived four categories: The physiology of the skin of newborns and their peculiarities; The nursing care of the skin premature neonate: benefits and drawbacks; Factors aggressive skin in newborns and its consequences and measures to promote skin integrity. Conclusion: it is a relatively new and complex issue for the neonatal nursing with little research done by these professionals. Descriptors: Skin, Neonate, Neonatology, Nursing. RESUMO


This study aims to develop seismic fragility curves for a typical pilesupported wharf. Fragility curve is one of the popular tools in seismic performance evaluation of a structure . The software FLAC2D was used to simulate the seismic performance of the wharf structure. Using eight time history records, occurred in past, as seismic loading, incremental dynamic analysis (IDA) was applied for seismic demand estimation. Based on the resulted seismic response matrix the analytical fragility curves were developed. As a prevailing tool, adopted fragility curves are useful for seismic risk assessment. They can also be used to optimize wharf-retrofit methods.


Releasing an upgraded version of a product is a common tactic that firms use to maintain competitiveness. However, in light of the significant research and development investment required to upgrade products, a new industry trend has emerged in which incumbents collaborate with market entrants to innovate products. At the same time, such collaboration may lead customers to think that the upgraded products are more similar than those innovated without collaboration. Consequently, we consider the following tradeoff: collaboration allows firms to share the innovation investment, but leads to less differentiated products. Specifically, we consider a two-period model where the incumbent is a monopoly during the first period. This incumbent and a market entrant decide whether or not to collaborate to innovate their products, and the two firms sell their products during the second period. We find that both firms can benefit from a higher innovation cost. Moreover, the market entrant can be better off when the products become less differentiated due to collaboration, or when customers are impatient to buy in the second period. Finally, we find customers can be worse off when there is a lower innovation cost or more differentiated products.


Designing a catalyst that combines the activity, selectivity, simple recovery, and follows the green chemistry instructions is of great importance. In the present study, Fe3O4@Pectin~Imidazole~SO3H-Cu(II) was synthesized as an efficient and biopolymer-based magnetic catalyst for the oxidation of benzyl alcohols to aldehydes using tert-butyl hydroperoxide (TBHP) as an oxidant under solvent-free conditions. The catalyst was characterized using Fourier Transform Infrared Spectroscopy (FT-IR), Powder X-Ray Diffraction (XRD), Vibrating Sample Magnetometer (VSM), Field Emission scanning electron microscopy (FE-SEM), Energy dispersive spectroscopy (EDX), Transmission electron microscopy (TEM), and inductively coupled plasma (ICP) atomic emission spectroscopy. The results indicated that our catalyst was quite active in oxidizing the benzyl alcohols to their corresponding aldehydes in the presence of TBHP. The efficiency with low catalyst loading, convenient work-up, isolation of pure products, use of inexpensive metal instead of precious metals, solvent-free condition, use of eco-friendly support, and also the sustainability of catalyst up to at least 5 consecutive runs without a special drop-in activity are some of the remarkable advantages of this protocol.


In a world where pristine environments are sometimes squeezed out of existence by the overabundance of one species — man — (and his many life‐support systems), it seems a matter of reason that some US acreage should be safeguarded, if for no other reason than to sustain the mechanism of photosynthesis.


Objective The interleukin-32(IL-32), a newly discovered cytokine, was reported to have increased expressions in the lung tissue of patients with chronic obstructive pulmonary disease (COPD) and correlated with the degree of airflow obstructions. This study was to undertake a randomized controlled trail to evaluate combined salmeterol/fluticasone on IL-32 and inflammatory cells in induced sputum and plasma of COPD patients and discuss whether IL-32 is related to the inflammatory disorder of COPD patients. Methods Using enzyme-linked immunosorbent assay, the expression of IL-32 in induced sputum and plasma was respectively examined to the following groups: 32 patients with stable COPD, 18 asymptomatic smokers, and 18 nonsmokers. COPD patients were treated in an open-labeled, randomized,parallel group and controlled trial with either a combination of 50 μg salmeterol and 500 μg fluticasone twice daily (SF, n = 18) or 21 μg salbutamol and 120 μg ipratropine quartic daily (IS, n = 18) for 3 months. At the start and end of treatment induced sputum was performed and the level of IL-32 was measured. Results IL-32 level in sputum and plasma of the four groups did not show significant differences. IL-32 level in sputum had no correlation to macrophage and neutrophil count in sputum,FEV1% predicted and SGRQ. IL-32 level in plasma of COPD patients had positive correlation to TNF-α level in plasma ( r=0. 65, P<0. 001). In addition, SGRQ was significantly reduced by SF ( P<0. 001)which was not seen with IS. SF did not significantly change IL-32 level in sputum and plasma,macrophage and neutrophil count in sputum and FEV1 % predicted compared with IS. Conclusions The results of this study suggested that although IL-32 was not related to the increase of inflammatory cells in induced sputum of COPD patients, it might be implicated in the systematic inflammatory disorder of COPD patients. SF improved the health status but did not significantly change IL-32 level and inflammatory cells in induced sputum of COPD patients.

Key words:
Airway inflammation; Chronic obstructive pulmonary disease; Inflammatory cytokines


A detailed remote sensing survey of the Aristarchus Plateau has been made in the W-visible-near infrared domain by means of earth-based telescopic and Clementine (1) CCD spectro-imaging techniques and the distribution of the main types of materials is proposed on the basis of their spectral characteristics, revealing that the Plateau contains a widespread mare basalt component, underlying pyroclastic deposits. The telescopic dataset (case 1) (CCDTHX 384x576 array)), obtained from the Pic-du-Midi Observatory under 15" phase angle during the October 1989 full Moon period comprises respectively 10 narrow spectral bands (0.4,0.56, 0.73, 0.91,0.95,0.97,0.98,0.99, 1.02, 1.05 /l m), with a 100 A bandwidth, a 0.8-1 km true spatial resolution and a S F of 70 to 80. The Clementine-data (case 2) (CCDTHX 384x288 array) comprise 5 bands (0.41, 0.75, 0.90, 0.95, 1.00 p m), with a 50 to 200 A bandwidth and a 200 m spatial resolution (1). The two spectral datasets have been instrumentally calibrated and two mosaics have been completed which cover a part of the Aristarchus Plateau (fig. 1) , the telescopic one (frame B) comprising two images and the Clementine strip (frame A) resulting from a sequence of 8 overlapping frames. A radiometric calibration has been made using telescopic and Galileo spectra (2,3,4). It results in the production of absolute reflectance spectra and relative reflectance spectra scaled to unity at 0.7310.75 /l m. The consistency between the two datasets is within 2-3%. A principal component analysis (PCA)is canied out on both datasets; the first two principal axes bear respectively 99.2 (case 1) and 98.5% (case 2) of the spectral variance (figs. 2b, 3b). From this analysis, mean spectra are produced for the main spectral components which are showed with their spatial distribution (figs. 2a, 3a). It reveals that: (i) the spectral characterization and associated mappings from both datasets are extremely consistent; it is to be noted however that the 0.56 /l m band available in the telescopic dataset is very important for the characterization of the visible continuum of the spectra and lacks in the orbital dataset; (ii) the common spectral units within the two windows consist in: -1) a mature mare basalt unit (unit 1 in figs. 2 and 3) embaying the Aristarchus Plateau and locally detected across the Plateau, in particular in Vallis Schroteri and some rilles walls (fig. 3; unit and spectruml' corresponding to a fresher material); -2) a specific Aristarchus Plateau unit which is however spectrally very close to the surrounding mare unit 1 and consequently calls for the presence of a significant mare basalt component in the material covering the Plateau; -3) local patches distributed across the Plateau and corresponding to very low albedo areas; unit 3 presents a very steep slope in the W-VIS domain and is spectrally very similar to Gruithuisen domes unit (5); it is related to the presence of pyroclastic dark mantling deposits; -4) unit 4 may be indicative of highlands material (ejecta, ...); iii) units 5,6,7 do not correspond to the same units depending on the considered mapping. In case 1 (figs. 3a and c), these units are spectrally characterized by a negative slope longward 0.56p m and a rather pronounced absorption feature in the 1 /l m. They map respectively the Aristarchus ejecta, the Herodotus and Cobra Head region. In case 2 (fig. 2a), it relates to Herodotus %(unit 5), Herodotus A and a mare area eastward of it (unit 6), and to a part of Agricola Mountains (upper left comer in fig. 2 a, high albedo markings). This first analysis reveals the complexity of the Aristarchus plateau and agrees with some of the results recently presented (6). It clearly shows that there is a prevailing mare basalt component present within the Plateau, underlying the pyroclastic deposits. It also shows that the region near Herodotus E, in Agricola Straits belongs to the same spectral unit than the overall Plateau. Finally, this study verifies the high level of consistency between UVNIS Clementine and earthbased telescopic high resolution spectro-imaging data.


An algorithm for selective extraction of visual saliency objects from color images and videos is presented. Color quantization based on vector quantization (VQ) is firstly performed; And then, quantized image is segmented according to its color and spatial distribution; thirdly, based on visual attention model, focuses of attention (FOAs) of objects are selected; finally, in term of shifts of FOAs and the Gestalt principle, saliency objects are extracted by merging color, texture, boundary and homogeneity features. Experimental results on the Corel image database and the TREC videos demonstrate the effectiveness of the proposed approach after the subjective evaluation.


Why should a bright young woman suddenly drive herself to starvation? Why does anorexia afflict so many women and girls? Marilyn Lawrence, a therapist with over 20 years' specialist experience, offers a clear and accessible guide to tackling this bewildering illness. She discusses: how to recognise anorexia in yourself and others the fallacy of the 'ideal weight' what treatments are available - their strengths and weaknesses how to resolve the conflicts which underpin anorexia practical ways of helping yourself and others


Aiming at rapid information perception and simulation calculation of landslide barrier body in the alpine and gorge region, this paper takes the Baige barrier lake in 2018 as the research object, it analyzes and summarizes the basic geometry characteristics of barrier body, based on this, a multi-resolution time series data perception method for the barrier body is proposed, collecting spatial data with multiple sensors of space, sky and earth is established jointly, and then for the complicated calculation problem of the traditional landslide barrier body, a fast calculation approach for simulating the sliding process of landslide barrier body and the weir crest elevation. These research provides a new methodology for barrier body data perception and fast calculation for the rescue and relief of the barrier lake.


I read with great interest the article by Paynter et al1 in which they investigated the relationship between lifestyle factors and cardiovascular disease (CVD) and whether additional information on these factors would provide improved CVD risk prediction in women. In this study, the authors provide observational evidence for an inverse association between healthy lifestyle factors and CVD, with a 45% reduction in risk with all factors.1 For a prediction point of view, they compared predictive value of models with lifestyle factors, the pooled cohort2 and Renold Risk Score3 models alone, and combined models with all factors, respectively.1 They conclude that the addition of lifestyle factors to traditional risk factors can …


approved: Susan J. Hall The purpose of this study was to assess the relative involvement of four muscles rectus abdominis, external obliques, rectus femoris, and the lumbar region of sacrospinalis during performances of eight different variations of the sit-up exercise. The sit-up variations investigated were long-lying sit-ups with/without feet support and hook-lying sit-ups with knee angles of 65, 90, and 105 degrees with/without feet support. Twenty-seven male volunteers between the ages of 20 and 36 years participated as subjects in the investigation. Myoelectric activity was monitored using an Orion Computerized System with a pair of surface electrodes positioned over each of the four muscles on the right side of the body. A clear plastic goniometer was aligned over the hip, knee, and ankle joints to measure knee angle. Three repetitions of each sit-up variation were performed, with sit-up variations administered to each subject in random order. One minute of rest was given between sit-up variations to minimize the influence of fatigue. A two-way ANOVA with repeated measures on both factors was used to evaluate differences in myoelectric activity levels. The main factors were feet support (supported/unsupported) and knee angle (long-lying or hooklying with 65, 90, and 105 degree knee angle). Statistical significance (p < .05) of mean differences were tested using the statistical software BMDP2V on the CYBER mainframe computer. Tukey's HSD or Bonferroni pairwise comparisons were used for evaluation of significant F values for knee ankle, while the Scheffe procedure was used to evaluate significant interaction effects. Sit-ups with feet unsupported produced significantly greater myoelectric activity than with feet supported in all selected muscle groups except the rectus femoris, where the reverse was true. The hook-lying sit-up with larger knee angle produced significantly greater myoelectric activity in the external obliques and the sacrospinalis. In the external oblique, only the mean comparison of long-lying vs. hooklying sit-up with 105 degree knee angle showed a significant interaction difference. Increased knee angle in hook-lying sit-ups resulted in increased involvement of the abdominal muscles. Myoelectric activity at the sacrospinalis site was greater with increasing knee angle and with the feet unsupported. These findings can be utilized by physical education instructors and by physicians in educating their students and patients as to the relative efficacy of the situp variations investigated. An Electromyographic Comparison of Eight Sit-Up Variations


Deficiency of alpha-1 antitrypsin (AAT) is only one endogenous factor promoting COPD development. The aim of the study was to determine AAT level in patients with COPD in remission stage and to determine the influence of this parameter on the frequency of disease exacerbations. We found that AAT level in the serum of patients with COPD is lower in comparison with healthy people. At the same time in 30% of patients suffering from COPD, AAT level in the serum is below normal and reduces significantly with the progression of the disease. A negative correlation between AAT level and the average number of exacerbations per year was established. Probably, the number of exacerbations per year in COPD patients with low AAT level has a tendency to increase


Genus Zanthoxylum L. comprises about 200 species distributed in Asia, Africa, Australia and North America [3] . In Vietnam, there are about 12 species belonging to genus Zanthoxylum [1] . Many species in this genus are used as medicine, as spices or sources of essential oils. The fruit of Zanthoxylum rhetsa (Roxb.) DC. (Vietnamese name: "Sẻn hôi") was collected in Ha Quang district (Cao Bang province). Microscopical characteristics of the fruit were investigated using light microscope. From fruit of Z. rhetsa , the essential oil was obtained by hydrodistillation. The gas chromatography combined mass spectrometry (GC/MS) analyse of essential oil led to the identification 25 compounds, accounting for 98.72% of the total essential oil content. The main components are Sabinene (64.80%), Terpinen-4-ol (6.07%), β-Pinene (4.81%), α-Pinene (4.09%), 1.8-Cineol (2.49%) and β-Phellandrene (2.90%). The essential oil of Z. rhetsa strongly inhibited NO production, with IC 50 value was 16.42 ng/ml. These results demonstrate that essential oils from the fruit of Z. rhetsa possesses excellent anti-inflammatory activity and thus have great potential in treatment of inflammation.


Four europium compounds, LiEuAsS 3 ( I), KEuAsS 3 ( IIa), RbEuAsS 3 ( IIb), and CsEuAsS 3 ( IIc), containing As (3+) were synthesized in molten alkali-metal polysulfide salts. An As-rich flux was found to be necessary to stabilize the pyramidal building unit [AsS 3] (3-). All crystallize in the monoclinic space group P2 1/ c with two new structure types. Compound I features a new coordination mode for the [AsS 3] (3-) unit and three-dimensional [Eu(AsS 3)] (-) framework. Compounds IIa- c are isostructural and feature a layer of [Eu(AsS 3)] (-) with an unusual mu 5-sulfide anion in a umbrella-like geometry. The compounds are paramagnetic semiconductors with an energy gap of approximately 2.0 eV.


FVIII deficiency or inactivity leads to coagulation malfunction known as Hemophilia A (HA). FVIII overactivity on the contrary is commonly linked to a hypercoagulability state. In steady state, FVIII remains quiescent by forming a non-covalent complex with vWF, and upon coagulation cascade activation, thrombin liberates active FVIII (FVIIIa) from vWF. FVIIIa binds to the plasma membrane of the platelets and other blood cells via its C2 domain phospholipids binding motif to exert its coagulative role.
 Recently, we developed a reliable Flow-Cytometry (FC) platform for FVIII protein detection (Elnaggar M. et al, 2020). The assay is suitable to measure both intracellular and extracellular FVIII. When applied to human blood it showed that by overexpressing FVIII through a lentiviral-vector-based transduction, a high proportion of circulating FVIII is bound on leukocytes membranes. Leukocyte abundance is reported to be highly associated with thrombotic events but with no clear mechanistic explanation. Therefore, we sought to evaluate the percentage of FVIIIa bound on different leukocyte subsets (T cells, B cells, monocytes and granulocytes) in different clinical scenarios, including HA and other abnormal coagulation states and to correlate it to the plasmatic levels of FVIII.
 The analysis was conducted on 31 pediatric/young-adult subjects (median age 9y), including patients diagnosed with HA (n=8), patients with coagulopathies (von Willebrand Disease, menorrhagia and unexplained bleedings (n=11) and 1 patient with known high levels of FVIII), and patients without coagulopathies/healthy controls (n=11) referred to Hematology/Oncology clinic at Sidra Medicine-Qatar.
 Fresh blood samples were analyzed with a Sysmex XN1000 Hematologic Counter for complete blood count and with a BD-Symphony FC for the following surface markers: CD3/CD4/CD8/CD14/CD16/CD19/CD33/Live/Dead and for FVIII protein A2 domain (Ab clone GMA8024), after light-chain Zenon-labeling, with proper IgG controls, as described in the publication above. In parallel, plasma FVIII measurements were performed for clinical diagnostic purposes, and results were correlated.
 Expectedly, HA patients showed the lowest FVIII percentage in plasma (p<0.0001), while leukocytes' surface FVIII was generally low (on average <1%), trended to a lower rate in patients with coagulopathies and HA compared to healthy-controls and was significantly higher in the patient with hypercoagulability (p=0.0007). Surprisingly, among leukocytes' subpopulations, screened on patients with bleeding diathesis and HA subjects vs healthy-controls, only CD8-surface bound FVIIIa was significantly lower compared to healthy-controls (p=0.015 healthy-controls vs HA, and p=0,0093 healthy-controls vs bleeding diathesis). These results raise the possibility of a CD8-cell mediated controlled binding mechanism regulating FVIII availability in case of biological need of the protein, as bleeding.
 We did not find any significant correlation between leukocyte-surface bound FVIII and plasma FVIII level, and this further indicates that the differences in FVIIIa leukocyte surface binding are not directly proportional to FVIII availability in the circulation, rather actively regulated by a biological still unknown mechanism.
 While the study is still ongoing and recruiting other subjects with hypercoagulation state, we showed in this preliminary analysis that our in-house FC platform for FVIII protein detection screens in depth FVIII protein adherence to blood cells, may shed light on coagulation novel mechanisms, and potentially serve as a diagnostic and prognostic tool.
 Figure 1 Figure 1.

 No relevant conflicts of interest to declare.


Table of Contents
1. 1989 and the Transformations in Eastern Europe Terry Cox 2. The Demise of the Soviet Bloc Mark Kramer 3. Welfare Dictatorship, the Working Class and the Change of Regimes in East Germany and Hungary Eszter Bartha 4. New Life: The Poetics of Transition George Szirtes 5. The Picnic on the Border: An Interview with Laszlo Vass Terry Cox 6. Three Days in Bucharest: Making Sense of Romania's Transitional Violence, 20 Years On John Gledhill 7. A Post-Socialist Capitalism Nigel Swain 8. After the Party, the After-Parties? The Effects of Communist Successor Parties on Economic Reform in Central and Eastern Europe Aleksandra Sznajder Lee 9. Satisfied, Sceptical or Simply Indifferent? Current Public Opinion towards the Fall of Communism in the Czech Republic Pat Lyons and Alžbĕta Bernardyova 10. Evaluating Transitions: Human Rights and Qualitative Democracy in Central and Eastern Europe Brad K. Blitz

Brief summary of the description:
This book presents a selection of recent research on the events and developments of 1989 in Eastern Europe. It offers a mix of detailed examinations of the events of 1989 in Eastern Europe, thoughtful and considered appraisals of developments, and 'middle-range' theoretical discussions of patterns of cause and effect. The authors range in their approaches from detailed examinations of government and ruling-party papers from the archives, some of it originally labelled top secret, to personal observations and oral history based on interviews with participants, to analysis of survey data and official statistics. In their chosen focus the essays range from explorations of the emerging crisis in the communist regimes that led to the events of 1989, reflections and insights into the events and changing mood during 1989 itself, and examinations of some of the consequences and legacies of 1989.


A comparison of blind and sighted readers, using Goodman's Reading Miscue Inventory, was conducted using 22 blind students enrolled in both public and residential schools. Blind braille readers' miscues were compared to those of sighted readers. Results revealed that similarities were greater than differences. Print and braille readers had approximately the same proportion of miscues in substitutions, omissions, insertions, reversals across words, and more miscues in graphic than sound similarity. Differences were found in more unsuccessful corrections for braille readers.


For the mathematical model of electrical impedance tomography,it is changed into discrete form based on isoparametric finite element methods and described as a nonlinear optimization problem, computational formulas of the gradient and Hessian matrix are presented;The concept of pseudo element stiffness matrix is introduced,and its invariance during the iteration is useful for improving the computational efficiency.The BFGS method and Goldfeld modified Gauss-Newton method are adopted in numerical simulation for 3-dimensional EIT,numerical simulation results show that these methods are valid,and the relevant problems are pointed out.


The distribution of donor cells in the lymphoid organs of mice suffering from acute runt disease was investigated by means of the cytological marker (T6). In all the strain combinations studied relatively low proportions of donor cells were identified in the spleen and bone marrow. In the A→CBA-T6T6 and C57BL→CBA-T6T6 combinations high proportions of donor cells were found in the lymph nodes and thymus. Few donor cells at all lymphoid sites were identified in the CBA-T6T6→C57BL combination, though the recipients showed unquestionable clinico-pathological signs of runt disease.

Despite marked splenomegaly in 12-day-old runts, the mean total number of cells in the spleen was similar to that in normal mice and mice injected at birth with isologous cells. In the A→CBA-T6T6 and C57BL→CBA-T6T6 combinations donor cells significantly contributed to the total cellularity of the enlarged spleen, in contrast to the CBA-T6T6→C57BL combination in which the host's spleen consisted almost exclusively of host cells.

Grafting tests showed that runted mice can be either non-specifically or specifically tolerant which seemed to depend on the degree of lymphoid atrophy and the degree of chimerism. Some of the animals that eventually rejected skin grafts from spleen inoculum donors, continued to be chimeric for donor lymphoid cells.

A mechanism for runt disease could be mutual interaction between donor and host cell populations causing reduction of the host's lymphoid reserve and consequent appearance of clinical symptoms of disease.


In this reflection addresses the need to conceive of education as part of an affordable coexistence of differences, and as such, it is a promoter of intercultural dialogue, which should lead to each one of the cultures that come into discussion, are in equal positions. This relates to the struggle of desopresión proposed by Paulo Freire. But from there, collecting from the conception of justice Rawls, the importance of not stay stuck in this multicultural recognition, but it's necessary to deepen the appreciation of the dignity and differences of the individual as such, The different, which can be a real desopresión.


Optically triggered twisted intramolecular charge transfer (TICT) states in donor-acceptor chromophores form the molecular basis for designing bio-imaging probes that sense polarity, microviscosity or pH in vivo.[1] However, a lack of predictive understanding of the 'twist' localization has limited rational structure-function correlations for TICT-based dyes. Time-resolved absorption and emission spectroscopy traditionally used to address this problem, could never unequivoally identify the twist location.[2] Here, using femtosecond stimulated Raman spectroscopy, we reveal distinct Raman signature of the TICT state for stilbazolium-class of mitochondrial staining dye for the first time.[3] Resonance-selective probing of 4-N,N-diethylamino4 ̋-Nˊ-methyl-stilbazolium tosylate (DEST) tracks the excited state structure as it relaxes to a TICT state on a picosecond timescale. The remarkably blue-shifted C=C stretching mode at 1650 cm-1 in the TICT state is attributed to the 'twist' of a single bond adjacent to the ethylenic π-bridge in the DEST backbone through detailed electronic struture and vibrational calculations. Our work demonstrates that the π-bridge connecting the donor and acceptor moeity influences the spatial location of the "twist", and offers new perspective for designing organelle-specific probes through rational tuning of backbone dynamics.


Thus the converse inference is Tauberian in nature. On the other hand, it seems to be hard to find a Tauberian theorem applicable to the present case. Consequently, a direct approach is needed. Correspondingly, the proof of (i)-(ii), though straightforward, is somewhat lengthy, and will be published elsewhere. It applies also when Dirichlet's divisor problem, which can be thought of as the problem of lattice points in hyperbolas, is replaced by the problem of lattice points in circles.


Ultra Steep Spectrum (USS) radio sources are one of the efficient tracers of High Redshift Radio Galaxies (HzRGs). To search for HzRGs candidates, we investigate properties of a large sample of faint USS sources derived from our deep 325 MHz GMRT observations combined with 1.4 GHz VLA data on the two subfields (i.e., VLA-VIMOS VLT Deep Survey (VVDS) and Subaru X-ray Deep Field (SXDF)) in the XMM-LSS field. The available redshift estimates show that majority of our USS sample sources are at higher redshifts with the median redshifts ~ 1.18 and ~ 1.57 in the VLA-VVDS and SXDF fields. In the VLA-VVDS field, ~ 20% of USS sources lack the redshift estimates as well as the detection in the deep optical, IR surveys, and thus these sources may be considered as potential high-z candidates. The radio luminosity distributions suggest that a substantial fraction (~ 40%) of our USS sample sources are radio-loud sources, distributed over redshifts ~ 0.5 to 4.


Zn contents in soils of plantation bases for vegetable and fruit of Panxi,Sichuan Province were studied through sampling and analysis at assigned regions and sites.The results showed that the average Zn content was between 75.0 and 160mg/kg in this area.The rank of average Zn content of the soil in the bases is as follows: Salian Vegetable Base Panlian Vegetable Base Huili Pomegranate Base Datian Pomegranate Base Xiqu Mango and Longan Base Renhe Mango Base Yanbian Mango and Loquat Base.The Zn contents in three of the seven bases were beyond the Class Ⅱ of the environmental standard of soil.The Zn content in Datian Pomegranate Base got the most that was higher than standard by 16%,while the highest average value appeared in the two vegetables bases.


Boiling heat transfer experiments are performed on a Freon 113 upward flow in a uniformly heated tube, and the liquid film flow rate and the size of drops entrained in the vapor core are measured at the exit end of the heated tube. The exit film flow rate at the critical heat flux condition is near to zero in a range of low heat fluxes, but it shows a trend to increase with increasing heat flux over a certain value. An empirical equation for the arithmetical mean diameter of the entrained drops is proposed, and it has been shown that the size distribution of drops can be suitably described by a gamma distribution.


Techniques disclosed herein include an electro-chemical deposition apparatus that provides an efficient circulation system, chemical management that provides reliable and uniform plating, and a configuration that provides short maintenance times and greater tool availability. Techniques include a processing tank containing an anolyte fluid, and one or more plating cells each having a catholyte fluid compartment with a circulation path that connects to a separate or remote catholyte reservoir. Thus, with such a configuration, a single pump can be used to flow catholyte (via manifolds) through one or more plating cells. Thus, with the catholyte reservoir maintained off board, instead of dumping catholyte over a weir into a reservoir, catholyte fluid - after flowing through a plating cell - is returned to the catholyte reservoir.


This paper discusses the impact of Fixed Pattern Noise (FPN) on image compression embedded in CMOS sensors. This FPN is mainly due to technology dispersions as well as a non uniform topology of the layout. FPN is generally modelled as a non uniform affine mapping of the pixels. The Dark Signal Non-Uniformity (DSNU) represents the level of offset variations while Photo Response Non-Uniformity (PRNU) is the level of pixel gain variations. Once those two parameters are properly calibrated for each pixel, the image can be corrected by linear interpolations (i.e. affine correction). This operation requires specific processing and large memory resources to be implemented directly in the focal plane. If this 2-points correction is not performed inside the sensor, some problems arise in the context of embedded compression because the hypothesis on image sparsity is no longer satisfied. By considering this context, this paper presents a comparative study between a 2D Haar wavelet compression, separable Compressive Sensing (CS) and a novel approach combining wavelet based compression and row based CS. In the case of a high non uniformity of the focal plane (e.g. considerable technological dispersion), it appears that a proper combination of CS and Haar takes advantage of both enabling FPN correction at the reconstruction stage and outperforming the alternative techniques.


Purpose – Despite substantial declines in cigarette smoking in England since the 1970s, around 20 per cent of the adult population still smokes. In Sweden, 10 per cent of adult males and 12 per cent of adult females smoke cigarettes, while snus use is prevalent among 19 per cent of adult males and 4 per cent of adult females. Traditional cessation‐only approaches may need to be supplemented with broader tobacco harm reduction measures to reduce smoking prevalence further. General practitioners (GPs) are well placed to give patients advice on tobacco harm reduction. This paper seeks to address these issues.Design/methodology/approach – The authors administered an online survey to assess knowledge, perceptions and attitudes to tobacco and nicotine products to 220 GPs (100 in England and 120 in Sweden).Findings – Most GPs (96 [96 per cent] England, 115 [98 per cent] Sweden) addressed smoking cessation with patients as part of their regular practice. Most GPs (87 [87 per cent] England, 102 [85 per cent] Swede...


We investigate a cone in the symmetric group algebra introduced by Stembridge [2]. It is dual to the cone of monomial-positive immanants of n × n matrices with indeterminate entries. We present a new set of relations between elements of the dual cone, and use these relations to show that the cone is finitely generated for n = 6, generalizing Stembridge's result for n = 5.


Taking Guangxi as an example,this paper analyzed the relationship between financial development and economic growth in the western areas of China.By estimating and testing the VECM Model and the co-integrated relationship of the indexes,it's concluded that the long-term equilibrium between financial development and economic growth really exists.And on the basis of empirical verification,it also put forward some policy suggestions for promoting Guangxi's economic growth through financial development.


The article deals with screening concepts for the preparation of waste paper stock for various graphic paper grades based on household waste and taking into account the contraries contained, especially stickies. Comparisons of hole and slot screening, their efficiencies and the limits in slot size reduction are discussed. In conclusion, solutions for improving screening efficiency, such as connecting several screens in series, are given. The correct choice and arrangement of screening units for the removal of stickies requires a high degree of technical knowledge and a great deal of experience.


This paper explores the use of Free-Space Optical technology in community and consumer networks and develops a gigabit Free-Space Optical system using WDM bidirectional SFP fiber optical modules, demonstrating a new cost-effective design approach for high-capacity, non-interfering point-to-point technology with a range of up to 100 m. A low-cost free-space collimation and alignment system is designed and experimentally evaluated in a prototype system, successfully demonstrating operation over 125 m with a 6 dB power margin. The application of this system is considered for three types of Community Wireless Networks, addressing deployment scenarios, spectral availability regulations and safety concerns. © (2013) by the AIS/ICIS Administrative Office All rights reserved.


Design of embedded electromechanical power hinge mini actuators for electric aircraft concept. Samsonovich S.L (1),Ogoltsov I.I. (2), Stepanov V.S. (3), Rozhnin N.B. (4) Krylov N.V (5) Makarin M.A. (6) 1: D.Sc,professor, Moscow, Volokolamskoye highway 4, firstname.lastname@example.com 2: PhD,associate professor email@example.com 3: PhD, email@example.com 4: Senior Researcher PhD, email@example.com 5: postgraduate student, email@example.com, 6: postgraduate student, firstname.lastname@example.com. Abstract This report focuses on the results of the development of electromechanical power hinge minidrives and methods of their construction which allow embedding. The report examines the concept of electric aircraft in terms of the drive systems. The main features of electric power supply of aircraft drive systems are the ability to replace hydraulic lines by electric mains as well as installation of electromechanical or electro-hydrostatic actuators on the aircraft. Thus electromechanical or electro-hydrostatic drives can be used to control aerodynamics surfaces such as ailerons, elevating rudders, flaps and other. Often, it is necessary to use linear actuators and levers to provide the required torque. Loc


In the recent years the need of using a single antenna that operates with in different frequency bands is much needed, where it led to the existence of the multi hand antennas. In this project the performance of a triple-frequency monopole antenna for wireless application is presented. The proposed antenna comprises of a microstrip-fed monopole with an additional strips and a partial ground plane with four strips on the opposite side of the substrate. By adding these strips to this monopole, good resonant frequencies for the multi-band application are obtained at 2/2.4/5.8GHz. At a return loss of -lOdB the resonant frequencies 2GHz, 2.4GHz, and 5.8 GHz have covered the band widths of 0.24, 0.46, and 0.08 GHz respectively. A prototype of the proposed antenna had been constructed and experimentally studied. The simulated and measured results where compared to ensure that the proto type antenna will perform effectively when used. The proposed triple-frequency operation covers the range from 1GHz to 6GHz, with good antenna performance characteristic having a return loss less than -lOdB leading to an efficiency of more than 90%.


In the past few years the nitrohiran group of synthetic compounds has been in wide use. These compounds are effective antibacterial agents and, apparently, bacteria do not develop any degree of resistance to them even after prolonged treatment. Furaltadonc, 'Altafur'), is the most recent addition to the ~cries and preliminary work has shown that it ts an effective systemic antibacterial. Schrire and Engelbrecht (I 960) have demonstrated its effectivity against staphylococci resistance to antibiotics and this has confirmed in vitro Work already puhlisl,ed, Kefauver (1959), Brudenell ( 1960), Rowell & Stoll (1960), have also reported successful results on the use of Furaltaclone in a wide variety of infective processes. I 11 Bombay I have subjected Furaltadone to a clinical trial in the past year and the results of this investigation form the substance of this paper.


ABSTRACT Introduction: Reactive species play a dual deleterious and beneficial antioxidant role. Overproduction of reactive species can cause damage of cell structures, including lipids and membranes, proteins and DNA. Hydroxybenzoic acid belongs to a group of phenolic compounds. Hydroxybenzoic acids itself and its derivatives showed antioxidant properties against different type of free radicals and can prevent or decrease overproduction of reactive species. Methods: In this study we tested antioxidant properties of 14 different benzoic acid derivatives against superoxide radical. The antioxidant properties of tested compound were determined by Beauchamp and Fridovich methods (1971). We studied kinetics and relationship between structure and antioxidant activity of the compounds. Results: The monohydroxybenzoic derivatives showed the best antioxidant properties. The results showed different antioxidant properties of hydroxybenzoic acid derivatives in 5, 10, 15 and 20 minutes of the reaction. Very important is the position of -OH group to carboxylate group. The compounds with hydroxyl group in ortho and para position to the carboxylate group showed the best antioxidant properties. Derivatives with blocked -OH group showed very low antioxidant properties in comparison with derivatives with blocked -COOH group. Conclusion: The structure and position of hydroxyl group is very important for antioxidant acitivy.


An asymptotic theory is proposed for the peripheral transfer [Formula: see text] reaction at low energies within the three-body ([Formula: see text], [Formula: see text] and [Formula: see text]) model by combining the dispersion theory and DWBA, where [Formula: see text], [Formula: see text] and [Formula: see text] is a transferred particle. The contribution of the three-body ([Formula: see text], [Formula: see text] and [Formula: see text]) Coulomb dynamics of the transfer mechanism both to the peripheral partial amplitudes for the partial wave [Formula: see text] and to the DWBA amplitude is investigated. The results of the analysis of the differential cross sections of the specific proton transfer reactions at above-barrier energies are presented. New estimates and their uncertainties are obtained for values of the asymptotic normalization coefficients for [Formula: see text] and [Formula: see text] as well as for the direct astrophysical [Formula: see text] factors at stellar energy of the radiative capture [Formula: see text] and [Formula: see text] reactions.


A survey of the 6,161 admissions to a pediatric hospital of Caracas during 1976 was conducted to determine the frequency and some characteristics of those admissions due to birth defects. The charts of all patients in whom a birth defect had been suspected or diagnosed during admission were reviewed and analyzed. These admissions numbered 629, that is 10.2% of the total, and were categorized as follows: 1) Birth defects of genetic origin: a) single gene – 3.2%; b) polygenic – multifactorial – 3.3%; c) chromosomal – 0.7%. 2) Birth defects due to an intrauterine insult – 0.1%. 3) Birth defects of unknown or heterogenous causes – 2.9%. The mean length of hospitalization was higher for birth defects patients than for all admissions: 15.6 and 11.6 days, respectively. There was no difference in mortality during admission between birth defects patients and all admissions, both being rather high, 8.2 and 8.3%, respectively.

The lower prevalence of birth defects observed in this study as compared with North American surveys is due to several factors, among which the most relevant is the persistent burden of environmental infectious and nutritional diseases in the pediatric age population in Venezuela. Nevertheless, it is thought that the foreseeable improvement in medical care organization and socioeconomic conditions of the population will lead to a relative rise in the morbidity and mortality due to birth defects in the near future, as was the case in developed nations. Thus it is necessary to develop medical genetics services in major hospital centers in order to provide present and future demands of genetic care.


Purpose: improving efficiency of treatment patients with multi-resistant tuberculosis. Materials and methods: the results of treatment of 91 patients with multi-drug resistance tuberculosis  have been analyzed. Support of artificial pneumothorax with gaseous mix inclusive ozone was used in 30 cases. Results: the strict keeping of procedure allows to have expressed local and systemic activity with absence of side effects. Summary:  application of ozonated  solutions is effective and  economic method  of treatment  patients  with multi-drug resistance tuberculosis without strong fibrosis alterations in lungs. So, ozone therapy can be recommended in medical care of such contingent of patients.


We consider a Markovian jumping process with two absorbing barriers, for which the waiting-time distribution involves a position-dependent coefficient. We solve the Fokker-Planck equation with boundary conditions and calculate the mean first passage time (MFPT) which appears always finite, also for the subdiffusive case. Then, for the case of the jumping-size distribution in form of the Levy distribution, we determine the probability density distributions and MFPT by means of numerical simulations. Dependence of the results on process parameters, as well as on the Levy distribution width, is discussed.


Aids in idea stimulation and problem solving are presented. The forced relation technique forces random words together to stimulate thought. This can be done by the catalog method or by listing characteristics and alternatives until a novel idea occurs. A checklist designed for mathematical problem solving is given. The forms of questioning it provides include understanding the unknown and finding a connection between the data and the unknown. A vice-versa checklist, where consideration of the opposite encourages new ideas, is suggested. A self-questioning attitude is necessary for problem-solving. A word stimulation by checklist is also suggested.


Vijay Tendulkar is unquestionably a grand Indian playwright and is famous for his comprehensive artistic genius. However his strong suit is the language Marathi, but the versions of his plays in English have fascinated and amazed the audience at a great apart. His main power comes into view from his devotion to usually Indian, particularly Hindu problems which are intensely deep-rooted in the Indian socio-cultural philosophy. "Silence! The court is in Session", is one of the well highly praised plays of Vijay Tendulkar. The play discovers the anecdote of the relationship between Miss. Benare's illicit and Prof. Damle. Tendulkar depicts the condition of women of the middle class family in Indian societal context. He reveals how women in our society are offended, suffered, distressed and exploited. The main aim of this research article is to study the defeat of woman in "Silence ! The court is in session"


The utility model discloses a heavy type full gear high speed central differential motor, including a motor and a change gear box. The motor output shaft of the motor is connected with the change gearbox. The change gear box mainly includes a motor output shaft gear, a accessory gear, a first accessory gear, a differential and a second accessory gear. The motor output shaft gear is engaged with the accessory gear. A first accessory gear is fixed on the accessory gear. The first accessory gear and the second accessory gear on the differential are engaged. The utility model has advantages of safe operation, good running performance, vehicle turning avoidance, strong load-carrying capability and climbing capability and provides power for vehicles such as tricycles and traveling cars.


In this paper, we focus on the efficiency improvement of the content distribution network while endow this framework with controllability, where CHs(Content Helpers) have restricted distribution scope and thus the economic benefits of CP(Content Provider) are protected. We propose a novel controllable content distribution framework by using the blockchain technology as well as the iterative self organizing data analysis techniques algorithm (ISODATA), which is an improved k-means clustering method. To implement an incentive and consensus mechanism utilizing proof-of-stake, we employ smart contract to enforce content distribution in an autonomous way. We conduct some experiments to verify the validity and feasibility of the proposed framework. The experimental results demonstrated show that our framework has the advantages of high efficiency, low latency, and good scalability.


The development and implementation of novel diagnostic techniques has had a profound effect on microbiology laboratory services in recent decades. Traditional microscopy, culture and biochemical testing techniques have been the mainstay for identification and anti-microbial susceptibility testing of microorganisms for generations (1,2). While these tests remain the core basis and standard practice in most laboratories, new techniques, such as nucleic acid-based assays and mass spectrometry, are increasingly being used. In some cases, these are enhancing existing diagnostic algorithms and, in others, they are replacing traditional testing approaches. Although these new techniques are powerful and offer many potential advantages over traditional methods, they have a number of limitations. In the present note, we briefly review new and evolving testing modalities in the microbiology laboratory. It is important to note that we did not intend to provide an in-depth technical appraisal of testing modalities. Rather, our objective was to highlight a number of new testing modalities in the context of traditional testing for bedside clinicians.


Japanese black cattle farmers usually decrease cattle serum vitamin A levels during the fattening stage of production to improve beef marbling score. However, such conditioning can negatively impact cattle health and so it is desirable to able to non-intrusively monitor cattle serum vitamin A level (no blood samples) during this period. The objective of this study is to build an automated system to measure serum vitamin A level by capturing and analyzing the color of cattle pupil images. The system involves automated image capture of a cattle's pupil, extraction and analysis of the pupil's color (pupil color becomes reddish as the serum vitamin A decreases), and then finally a model estimates vitamin A level based on red and saturation components. The results obtained indicate the system has the potential to rapidly and non-intrusively monitor cattle vitamin A levels in real time. Background Japanese black cattle meat is globally renowned for its high quality. To achieve this high quality, marbling is the most influential factor for determining the beef quality grade in the USA, Japan, and Australia (Gotoh et al. 2014). The higher the Beef Marbling Standard (BMS) the higher the beef is priced. Thus, ensuring high BMS grades for the meat coming from their cattle is an important issue for cattle-fattening farmers. Research to date has established a direct correlation between vitamin A levels (VA) and BMS: visually assessed marbling scores were higher when cattle VA was low during the fattening period (Kruk et al. 2008). In Japan farmers manipulate Japanese black cattle VA to a low level (approximately 30 IU/dL) when the cattle are aged 16-24 months (Fig. 1) to raise beef BMS (Oka et al. 1998). For VA, 1IU is the biological equivalent of 0.3μg retinal, or 0.6μg beta-carotene. (Provided by Hyogo Prefectural Hokubu Agricultural Institute) Figure 1. Ideal serum VA level in cattle during the fattening stage. The vitamin A 30IU/dL line indicates the minimum desired level of VA in Japanese black cattle. 1 Asian-Australasian Conference on Precision Pastures and Livestock Farming zenodo.org/communities/pa17 2 However, such a low VA has the potential to deleteriously impact cattle health, for example nyctalopia, lacrimation and so on (O'Donoghue, 1955). Needless to say, the loss of cattle health can incur severe financial loss for the farmer; up to 1 million JPY. Hence, it is important for farmers to monitor the level of VA. Currently, the standard practice is to perform intrusive, time-consuming (at least 10 days) and expensive (2,000 JPY per assay) blood assays; not to mention being stressful for the cattle and imposing laborious work on the farmer. Thus, an alternative system which can nonintrusively monitor cattle VA would contribute to more efficient and better control of VA, as well as reducing stress and ensuring cattle health during the fattening period. Numerous reports have shown a linkage between VA levels and mammal eye characteristics. It has been reported that the papilledema, the edema of the optic nerve, provides the first objective signal of changes occurring to the optic disc as a result of low VA (Donkersgoed et al. 1988). Such a response has also been demonstrated in Japanese Black cattle using a converted video camera (Fukushima et al. 2014). VA levels not only influence the optic nerve, but also the retina: low VA levels in cattle result in retinal degeneration that can lead to increased tapetal reflection and loss of pigmentation of the non-tapetal fundus (Gelatt et al., Moore, 1941). To date though, most of these studies have required the restraint of cattle, and in some cases veterinary administration of mydriasis in the cattle's eye. This is not only stressful on the cattle, it also has the potential for obscuring results as VA is believed to decline as a result of the stress, or while being restrained (Adachi et al., 1998). Initial research by our group (Han et al. 2013) using a hand held camera has demonstrated a correlation between VA and eye color opening up the opportunity for a non-intrusive monitoring of cattle VA, which would avoid this stress. Therefore, the objective of this study is to develop a simple and non-stressful method for estimating serum VA levels by analysing the color of automatically captured images of the cattle's pupil.


Background. Sarcomas are rare malignant neoplasms that originate from a mesenchymal cell line. The epidermal growth factor receptor (EGF‐R) has been identified in these malignant neoplasms by immunohistochemical techniques.


The synthesis of optically active ethyl 4-chloro-3-X-butanoate derivatives la-d (X = OH, a; OCOCH3, b; OCOC3H7, c; OCH2C6H5, d) was realized using various biocatalytic approaches such as microbiological reduction of ethyl 4-chloro-3-oxobutanoate 2 with lactic acid bacteria, hydrolysis of lb-d by the hydrolytic enzymes PLE and BChE and the transesterification of la catalyzed by a lipase from Pseudomonas fluorescens (PFL).


This pilot research is to explore the efficacy of peer feedback in translation teaching and learning in the context where College English Test has great influence on university's language teaching and learning through a case study.It will shed some light on pedagogical thinking in the context of Chinese ESL teaching and learning.


The correct calculation of foot and ground contact forces and their application points is a crucial and indispensable step in path planning or human movement simulation. The purpose of this work is the development of a computational model of the human leg and foot that, using forward dynamic analysis with natural coordinates, accurately calculates the contact forces and its application points generated during the contact between the foot and the floor in level walking. The contact detection algorithm and contact force model were implemented in the multibody dynamics code Apollo in a forward and inverse dynamics perspective. A contact force law with a moderated coefficient of restitution is used to simulate the soft tissue contact with the ground of a leg and foot multibody model described with four anatomical segments. Contact detection is assured through the use of an iterative method that recurs to implicit surfaces, in particular planar, quadric and superquadric surfaces, to find possible contact pairs. The model was tested for simple test cases. With the purpose of correctly calculate the contact forces, an optimization process was implemented to find the best values for the size, position and orientation of the surfaces used to define the sole of the foot. The forces obtained through the contact force model with the values determined by the optimization were compared with experimentally measured values to evaluate the effectiveness of the optimization process.


Providing an apparatus for spectrum opportunity between or among a plurality of spectrum agile radio (SARA) means (301.i), primary means (302./) and a secondary device (303.i) shared ( 301.i), the system (300) and method. Primary means (302./) elapsed operating in licensed frequency band in the licensed radio systems. Secondary device (303.i) of any system / device is operated in an unlicensed frequency band. Each SARA device (301.i) maintains FIG spectrum opportunity (SOM) (200), the spectrum opportunity from the use of the spectrum in FIG SARA (301.i) and between SARA (301.i) shared SOM (200 )composition. SARA device (301 / i) of media to detect for signs of spectrum use, and may receive explicit information on spectrum usage from the main assembly (302./), followed by the SARA device (301.i) will be described in which it the SOM (200), and can share their SOM with other SARA device (301.i) (200).


Abstract For decades, scholars have argued that civic education practices, such as debates on controversial issues, have the capacity to enhance civic outcomes, including political knowledge, attentiveness, and interest. This study bridges the literature on political science education and political behavior by employing an experimental approach to assess the link between a specific civic education practice (controversial debates) and a cited indicator of political behavior (political interest). Three hundred and forty-one students in 13 American Politics classrooms at a four-year higher education institution were randomly assigned to a controversial debate curriculum. Our findings show that the treatment had no effect on political interest for the treatment groups as a whole, a finding that challenges our hypothesis that debates on controversial issues could increase political interest. Our findings also point to a relationship between taking an American Politics course and increased political attentiveness for nonwhite students.


The synergy of computational logistics and deep learning provides a new methodology and solution to the operational decisions of container terminal handling systems (CTHS) at the strategic, tactical, and executive levels. Above all, the container terminal logistics tactical operational complexity is discussed by computational logistics, and the liner handling volume (LHV) has important influences on a series of terminal scheduling decision problems. Subsequently, a feature-extraction-based lightweight convolutional and recurrent neural network adaptive computing model (FEB-LCR-ACM) is presented initially to predict the LHV by the fusion of multiple deep learning algorithms and mechanisms, especially for the specific feature extraction package of tsfresh. Consequently, the container-terminal-oriented logistics service scheduling decision support design paradigm is put forward tentatively by FEB-LCR-ACM. Finally, a typical large-scale container terminal of China is chosen to implement, execute, and evaluate the FEB-LCR-ACM based on the terminal running log around the indicator of LHV. In the case of severe vibration of LHV between 2 twenty-foot equivalent units (TEUs) and 4215 TEUs, while forecasting the LHV of 300 liners by the log of five years, the forecasting error within 100 TEUs almost accounts for 80%. When predicting the operation of 350 ships by the log of six years, the forecasting deviation within 100 TEUs reaches up to nearly 90%. The abovementioned two deep learning experimental performances with FEB-LCR-ACM are so far ahead of the forecasting results by the classical machine learning algorithm that is similar to Gaussian support vector machine. Consequently, the FEB-LCR-ACM achieves sufficiently good performance for the LHV prediction with a lightweight deep learning architecture based on the typical small datasets, and then it is supposed to overcome the operational nonlinearity, dynamics, coupling, and complexity of CTHS partially.


Weconducted asurvey ofarepresentative sample of all primary carephysicians intheprovince ofQudbec toascertain their patterns ofpreventive practice withrespect tocancer infour anatomical sites: breast, colon-rectum, cervix, andlung. Astratified randomsample of430physicians ingeneral practice wasinter- viewed individually andweighted population estimates derived. Physicians report teaching breast self-examination totheir patients (%percent), performing breast examination (99percent), taking paptests routinely (91percent), andpursuing anti-smoking counsel- ing(98percent). Veryfewofthemreport submitting their patients over50yearsofagetoannual mammography (8percent) or checking foroccult blood instools inpatients over45years ofage


The purpose of this study was to try to identify the impact of ambiguity and risk on the auditor's judgment about inherent risk and control risk when planning the audit. A second purpose was to determine how ambiguity tolerance/intolerance affects judgment.


The tendency of brands that have sprung up in Indonesia has given rise to unhealthy competition so violations have often sprung up. The problem faced is how to resolve dispute cases in Central Jakarta Commercial Court Decision No.15 / PDT.SUS / MEREK / 2015 Jo Cassation Decision No.557K / PDT.SUS-HKI / 2015 regarding the famous brand pierre cardin based on uu brand and legal protection against the owner of the famous brand Pierre Cardin of France for the registration of the Indonesian pierre cardin trademark received by the Directorate General of IPR. The research method used in this paper is a normative legal research method. Normative legal methods are research methods that use literature to discuss existing legal issues. Result research show that Central Jakarta Commercial Court Decision Number 15 / PDT.SUS/MEREK/ 2015 Jo Cassation Decision Number 557K / PDT.SUS-HKI / 2015 and Decision Number 49PK / Pdt.Sus-HKI / 2018 related to Pierre Cardin's trademark dispute not in accordance with the laws and regulations especially the Trademark Law p rotection of trademarks is specifically regulated in Articles 68 and 76 Paragraph (1) of the old Trademark Law and Articles 76 and 83 Paragraph (1) of the New Trademark Law. This article facilitates trademark owners if a violation occurs against their trademark, the trademark owner can file a lawsuit to the Commercial Court or with an alternative dispute resolution. Regarding the decision, the judge has not obeyed the norms governing the mark and the judge has violated the trademark rules.


Abstract We investigated the influence of the presence of large males on the mating tactics of small males of the stink bug Megacopta punctatissima (Montandon) (Hemiptera: Plataspidae) by using laboratory experiments. In the presence of large males, the mating acceptance rate of females (the proportion of copulating males to the number of courting males) and the mating success (the proportion of copulating males to the total number of males) of large males were significantly higher than those of small males. Therefore, sexual selection favors larger male body size at mating. Although only 15.4% of small males courted females in the presence of large males, 57.5% of small males courted females in the absence of large males. Consequently, the mating success of small males was conspicuously higher in the absence of large males than in the presence of large males. We suggest that small males adopt an alternative mating strategy in which their courtship behavior is the same as that of large males, but their decision to court females depends on the presence or absence of large rival males.


This study aims to determine the role of organizational communication for leaders in the work environment. Communication activities within an organization aim to establish mutual understanding and equate experiences among members of the organization. With good communication, an organization can run smoothly. On the other hand, lacking or absent communication, organizations can fall apart. Therefore, leadership in organizational communication is very important because the presence of the leader is one of the spearheads of success in the organization. The results of the study concluded that communication in a leadership is a very important element in achieving the success of the goals to be achieved by an organization. Therefore, a leader should be good at communicating both verbally and non-verbally. Good communication will be able to increase motivation, so that the information conveyed can be well received and this will be able to improve performance and work control will also be carried out properly. In an organization the leader is a communicator. Effective leaders generally have effective communication skills, so that more or less will be able to stimulate the participation of the people they lead.


In the talk of Cairo musicians who play for marriages, the frequency of the theme of a descent from love to shame is evidence of a longing for social recognition and respectability that contrasts with their status, which is associated with a feeling of discomfort shared within the profession. Recurrently suspected of moral deviancy, these musicians are held at a social distance, a factor reinforcing their different lifestyle. The professional practice of music leads to situations that are alien to the urban circles where musicians perform. Although they are outsiders not belonging to the neighborhood, family or public, these musicians gain access to the intimacy of private places on major social occasions. This presence is ambivalent. In an « appropriated », « privatized » space, musicians are both a source of « subjectivation » and a potential source of trouble. The apparent paradox of their marginal status corresponds to an estrangement in urban society. In this respect, they are an emblem of urban living conditions.


The different expression genes cloning techniques are divided into three phases, on the base of the procreant era and techniques used of them. The principle, advantage and flaw of a series genes cloning methods are also introduced. This essay provide convenience for investigator on choosing experiment means.


Figure 1. A baby required active resuscitation when he was born at 26 weeks of gestation weighing 918 g. The Apgar scores were 2, 3, and 7 at 1, 5, and 10 minutes, respectively. The early neonatal period was complicated by systemic hypotension and respiratory distress syndrome. The infant was given inotropic support, surfactant, and antibiotics. A patent ductus arteriosus was surgically ligated after a trial of indomethacin failed. The infant was intubated and received oxygen for 51 days, and he achieved full enteral feeding on day 26. On day 52 extensive abdominal distention, bilious gastric aspirate, frank blood in . . .


A joint nonideal uniform array's self-calibration algorithm that can calibrate the array model errors(gain and phase uncertainties and sensor mutual coupling)is proposed.Based on the H~∞filtering technique,which was introduced in robust control theory, the more robust estimation of DOA(Direction of Arrival)can be achieved in this algorithm.Combined with the alternate iterative optimal technique,which has strict limit to initial value,this algorithm can precisely calibrate array larger model errors and get exact estimation of DOA simultaneously.The theoretical analysis and simulation results not only confirm this algorithm extends the self-calibration technique's limits of array larger model errors,but also show its good potential in applications.


Both SLA chapters investigate Spanish instruction. Focusing on differential object marking, Bowles and Montrul examine the effectiveness of online training modules that offer explicit explanations and opportunities for practice with corrective feedback. De la Fuente compares the effects of explicit versus implicit tasks on learners' noticing and acquisition of discourse markers. A major shortcoming of the volume is the length of chapters. With each contribution limited to approximately 10 pages, the authors are restricted in what they report and discuss. Chapters feel like summaries, and readers may fi nish the book with a desire to know more about the individual studies. Of course, brevity may also be considered a strong point. Because the authors succinctly present the main points of their work, the book would serve well as a source for assigned readings in a survey course of linguistics or applied linguistics.


We present a 2 GW peak power ring cavity diode-pumped Tm:YAP regenerative amplifier operating at 1 kHz repetition rate and centered at 1940 nm with 360 fs pulse duration.


The present invention relates to an amino acid salt of atorvastatin, atorvastatin is reacted with a basic amino acid to give such compounds, methods for their preparation: ⑴ weighed atorvastatin acid, is dissolved in a C1-C6 alcohol solvent, water or a halogenated hydrocarbon solvent, dissolved to form a solution a; ⑵ basic amino acid was weighed, dissolved in an alcohol solvent or water and a C1-C6, dissolved to form a solution b; ⑶ acetate solution was added the above solution a, the mixed solution began to clarify the the mother liquor precipitated crystals, i.e. acid salt of atorvastatin. Amino acid salts of atorvastatin prepared in the present invention not only has the effect of treatment of high cholesterol and blood lipids combined hyperlipidemia, but also has the function to increase amino acid, such as arginine for protection of liver function, so the invention salts effectively compensate for deficiencies known side effects of calcium, potassium and sodium salt of liver damage.


This program aims to create access to the creation of new entrepreneurs by developing / training students to have production process skills in the field of healthy food chemistry and chemistry and having the skills to run businesses based on local food products. The program also aims to encourage the development of lecturer and student research results to be utilized and socialized. One of the products produced in this program is Sarabba Instan. Sarabba Instan is a traditional Bugis-Makassar health drink made from ginger Enrekang. Instant Sarabba is made through several stages of production, namely stripping, drying, extracting ginger juice, stirring, and drying. In this program, the production of instant sarabba is carried out until the taste and processing are stable with the selection of quality basic ingredients. Organoleptic testing is done to determine the level of consumer preference for Instant Sarabba. Organoleptic testing was carried out by panelists from several circles on campus, namely lecturers, staff, and students. The results showed that the three groups liked Sarabba Instan with a percentage of preference of 90.91%, 85.72%, and 66.68% respectively for lecturers, employees, and students. Sarabba Instan is a superior food innovation product because of its more practical and healthy presentation. The Sarabba Instan PPUPIK program is an instant production center for Sarabba conducting Training, Seminar workshops, entrepreneurial exhibitions for students who have and want to run a business and community who need coaching.


The proteasome contributes to the generation of most of the peptide ligands of MHC class I molecules. To compare the identity of the peptides generated by the proteasome with those finally presented by MHC class I molecules, we generated a monoclonal antibody recognizing the C‐terminal part of the dominant H2‐K d ligand SYFPEITHI derived from the JAK1 tyrosine kinase. Immunoprecipitations of lysates from H2‐K d ‐expressing or non‐expressing cells revealed that only in the presence of H2‐K d SYFPEITHI could be isolated. No longer potential precursor peptide containing SYFPEITHI could be detected. Surprisingly, a peptide lacking the first two amino acids, FPEITHI, was isolated independently of the presence of H2‐K d molecules. The detection of only SYFPEITHI and FPEITHI in cell lysates corresponded with the strong generation of these two peptides in in vitro digests of elongated SYFPEITHI‐containing peptides with purified 20S proteasomes. Our results indicate that MHC ligands can be generated directly by the proteasome in vivo and that at least for SYF PEITHI the expression of the corresponding MHC molecule is critical for protection of the ligand in vivo.


Chronic hepatitis B virus (HBV) infection is a major cause of liver-related morbidity and mortality worldwide and is endemic in many areas of Asia and Africa. Adequate treatment of hepatitis B with effective antiviral agents can improve disease burden. Entecavir is a potent, selective nucleoside analogue with activity against HBV. In recent years, studies have been done on the safety, efficacy, resistance profile and therapeutic use of entecavir. This review will discuss pharmacological and clinical aspects of oral entecavir for use in adults with chronic hepatitis B virus infection.


A packet processing method includes receiving a forwarding decision made for an input packet; and creating a packet processing list of the input packet according to the forwarding decision. When the forwarding decision indicates that the input packet is required to undergo first packet processing operations, each including a common processing operation and an individual processing operation, to generate first output packets forwarded via first egress ports, respectively, first information indicative of the first egress ports is recorded in an egress port field of a first session of the packet processing list; second information indicative of the common processing operation shared by all of the first packet processing operations is recorded in a common processing field of the first session; and third information indicative of individual processing operations of the first packet processing operations is recorded in an individual processing field of the first session.


In the present work the classical problem of harmonic oscillator in the hyperbolic spaceH 2 2 : z 2 +z 2 z 2 2 z 2 3 = R 2 has been completely solved in framework of Hamilton{Jacobi equation. We have shown that the harmonic oscillator on H 2 2 , as in the other spaces with constant curvature, is exactly solvable and belongs to the class of maximally superintegrable system. We have proved that all the bounded classical trajectories are closed and periodic. The orbits of motion are ellipses or circles for bounded motion and ultraellipses or equidistant curve for infinite ones.


Abstract 2981 We recently reported that adhesion molecule CD82 is aberrantly expressed in CD34 + /CD38 − leukemia stem cells (LSCs) (ASH 2010; Abstract 2168.). Here, we report the results of a functional analysis of CD82 in CD34 + /CD38 − acute myelogenous leukemia (AML) cells. Short hairpin (sh)RNA-mediated downregulation of CD82 resulted in dephosphorylation of STAT5 and a decrease in the level of IL-10. In contrast, forced expression of CD82 in CD34 + /CD38 + AML cells by transduction with CD82-expressing lentiviral particles resulted in an increase in the levels of p-STAT5 and IL-10. Chromatin immunoprecipitation (ChIP) assay results indicated that STAT5A binds to the promoter region of the IL-10 gene, while reporter gene assay results indicated stimulation of IL-10 expression at the transcriptional level. These results suggest that CD82 positively regulates the STAT5/IL-10 signaling pathway. Notably, exposure of CD34 + /CD38 − AML cells to IL-10 stimulated clonogenic growth of these cells. Moreover, shRNA-mediated downregulation of CD82 expression in CD34 + /CD38 − AML cells impaired AML reconstitution in immunodeficient mice in parallel with downregulation of STAT5. Taken together, our data suggest that the CD82/STAT5/IL-10 signaling pathway is involved in the survival of CD34 + /CD38 − AML cells and may thus be a promising therapeutic target for eradication of AML LSCs. Disclosures: No relevant conflicts of interest to declare.


For a sheet-processing rotary printing machine, a usable for non-stop operation of the auxiliary pile carrier (20) is proposed, the consecutive via axially parallel swivel joints (30, 31) directly adjoin one another hinged support members (26; 26 '), and in an insertion direction (21) is a standby position into a working position and vice versa adjustable. The support members (26; 26 ') have on their pivots (30, 31) protruding extensions (32, 33), of which a respective counter to the insertion direction (21) oriented facing in the direction of insertion (21) extension (32) of the next trailing in the insertion direction (21) support member (26; 26 ') engages below. If the extensions (32, 33) to each other in such a way associated support members (26; 26 ') forcibly held in mutual abutment, so take the thereto with respect to the insertion direction (21) following downstream support members (26; 26') has a stretched position and it results an auxiliary stack carrier (20), which is in particular under a feed table and accommodated conveniently used.


On the basis of literature survey, this paper combines qualitative research with quantitative research to evaluate the influencing factors of expressway project risk under PPP mode. This paper starts from three parts:Firstly, starting from the current situation of expressway construction projects at home and abroad through the analysis of the advantages and disadvantages of PPP mode and three characteristics, the necessity and importance of project risk management under PPP mode are obtained. Secondly, the paper elaborates the risk of PPP project of expressway identifies the corresponding risk, and initially determines the three major factors affecting the risk of expressway project under PPP mode. Finally, according to expert judgment, the most critical factor is determined and a scientific, reasonable and effective risk factor evaluation index system is established. The index system includes three first-level indicators and six second-level indicators. On this basis, the judgment matrix is constructed by using the analytic hierarchy process, so as to form the influencing factor model. Finally, taking Fuling-Fengdu Expressway in Chongqing as an example, this paper uses the analytic hierarchy process (AHP) to carry out an empirical study on the model, in order to determine the importance of different risk factors.


Introduction: Skin cancer is the most common cancer worldwide and in Brazil represents 25% of cases of cancer. Brazil is a developing country with a large territorial dimension and not many people have access to information and healthcare providers. Teledermatology is already being used in programs for cancer prevention in a mobile unit at Barretos Cancer Hospital. The aim of this study was to assess the incremental value of the use of a clinical questionnaire added to digital photography to improve the screening of skin cancer. Methods: A total of 623 patients were included. In the first phase of the study, 436 patients were screened for skin malignancy from February 2010 to July 2011. In the second phase, 186 patients were screened between June and July 2012. All patients had their skin lesions photographed. In the second phase of the study, information on medical and family history, physical characteristics of the lesion and risk factors was collected. Photographs and clinical information from the second phase only were sent to the Barretos Cancer Hospital for diagnosis by medical specialists. Sensitivity, specificity, positive and negative predictive values and accuracy of observers were analysed, using the pathology diagnosis as the gold standard. Results: The majority of lesions in the first and second phases (68.3% and 64%, respectively), were classified as basocellular carcinoma, and melanoma represented 1.4% and 2.2%, respectively, of skin cancers. The specificity and positive predictive values in the first and second phases of the study regarding observers 1 and 2 changed significantly with the addition of a clinical


Objective:To explore the clinical effects and adverse reaction of treating epilepsy with topiramate.Method:60 cases patients were divided randomly into intervention group (30 cases) and control group (30 cases),the intervention group was treated with topiramate,and the control group was treated with carbamazepine.During the treatment the onset of seizure and adverse reaction were recorded and compared the clinical efficacy of them.Result:The total effective rate and control rate in intervention group was 83.33% and 30.00% respectively,which was 66.67% and 16.67% in control group respectively.There was a significant difference between the two groups(P0.05).Main side effects in intervention group and control group were weight decrease,somnolence,nausea and speech disorder,but the side effects of control group(60.00%) were more than those of control intervention group(30.00%),there was a significant difference between the two groups(P0.05).Conclusions:Topiramate has a good curative effect in treating epilepsy,minor side reaction and hence is worthy of being recommended in clinical practice.


Artificial rubber with the light-altering properties of a liquid crystal has been turned into a new type of laser--one that emits light without mirrors or a cavity and that changes its wavelength when pulled like taffy. Researchers call the work a significant step that might lead to the development of a low-cost, tunable laser.


Over the last decades, a great variety of data mining techniques have been developed to reach goals concerning Knowledge Discovery in Databases. Among them, cluster detection techniques are of major importance. Although these techniques have already been largely explored in the scientific literature, there are at least two important open issues: the existent algorithms are not scalable for large high‐dimensional datasets, and the unsupervised nature of traditional data clustering makes it very difficult to generate meaningful clusters. This article presents an overview of the strategies being explored in order to deal more deeply with these issues. Moreover, it describes a new semi‐supervised clustering strategy that exemplifies the integration of several approaches and that can be employed with partitioning algorithms, such as PAM and Clarans. The technique addresses an improvement to these types of algorithms, which is obtained by using must‐link feedback information provided by the users in an interactive and visual environment. WIREs Data Mining Knowl Discov 2014, 4:161–177. doi: 10.1002/widm.1127


Mud cuttings transport plays a very important role for the well drilling plan and operation. Especial for slimhole well drilling, the efficient removal of mud cuttings from drilled wells is considered a necessity for the success of the well drilling plan operation. However, there are still a little limited number of works relating to the mud cuttings transport in slimhole wells. In this article, two models developed from empirical approaches, namely Larsen's model and Rubiandini's model, were employed to consider the mud cuttings transport in slimhole well drilling. The effects of various drilling factors to the minimum flow velocity and flow rate required for an effective mud cuttings transport were investigated through simulation scenarios of case studies. The calculations from two empirical models showed that both models have the same trend for the minimum flow velocity and flow rate required for the transportation of mud cuttings with drilling parameters, such as rate of penetration (ROP), mud weight (MW), mud rheology, etc. Furthermore, several recommendations on how to achieve better mud cuttings transport are proposed from the obtained simulation results when using Larsen's and Rubiandini's models for calculating the critical mud flow rates in slimhole well drilling.


Effect of several irrigation of sugar industry effluent was studied on vegetative and yield characteristics of Brassica campestris L. var. Varuna type 59. Crop showed vigrous enhancement inalmost all the vegetative and yield characteristics studied and generally it was seen that the enhancement in vegetative and yield characteristics are directly related to the number of irrigation with sugar industry effluents. Maximum increaseinalmost all the parameters was recorded in T3 treatment (all the three irrigations with the sugar industry effluent). This enhancement in vegetative characters may be due to the suitable pH and chemical composition of the sugar industry effluent. The presence of nitrogen, phosphorus, magnesium and sulphur etc. ineffluent play important roles in growth and development of the plants by taking part in some of the vital processes.


The biochemical activities of cofilin are controversial. We demonstrated that porcine cofilin severs actin filaments and accelerates monomer release at the pointed ends. At pH 7.1, 0.8 μM cofilin cut filaments (2.2 μM actin) about every 290 subunits and increased the depolymerization rate 6.4‐fold. A kink in the major α‐helix of cofilin is thought to constitute a contact site for actin. Side chain hydroxyl groups of Ser119, Ser120 and Tyr82 in cofilin form hydrogen bonds with main chain carbonyl moieties from the helix, causing the kink. We eliminated side chain hydroxyls by Ser→Ala and/or Tyr→Phe mutagenesis. Severing and depolymerization‐enhancing activities were reduced dramatically in an Ala120 mutant, whereas the latter was decreased in a Phe82 mutant with a relatively small effect on severing, suggesting different structural bases for the two activities of cofilin. The Ala120‐equivalent mutation in yeast cofilin affected cell growth, whereas that of the Phe82‐equivalent had no effect in yeast. These results indicate the physiological significance of the severing activity of cofilin that is brought about by the kink in the helix.


People mostly facilitate and manage their social
lives adhering to the prevalent norms. There are some norms
which are unpopular, yet people adhere to them. Ironically,
people at individual level do not agree to these norms, but,
they still follow and even facilitate them. Irrespective of the
social and psychological reasons behind their persistence, sometimes,
for societal good, it is necessary to oppose and possibly
avert the unpopular norms. In this paper, we model theorydriven
computational specifications of Emperor's Dilemma into
an agent-based simulation, to understand the the conditions
that result in emergence of unpopular norms. The reciprocal
nature of persistence and aversion of norms, thus, is utilized
to define situations under which these norms can be changed
and averted. Simulation is performed under many interesting
"what-if" questions. The simulation results reveal that under high
density conditions of agent population with a high percentage of
norm aversion activists, the aversion of unpopular norms can be
achieved.


Objective To study the content of calcium ion solubility with different compatibility and to explore the compatible regularity of Baihu Decoction.MethodsThe direct titration was used to study the content of soluble calcium ion of each single herb of Baihu Decoction,their different compatibility,different soaking and boiling time of decoction.ResultsAll of herbs in Baihu Decoction contain calcium.Gypsum had the highest content of calcium,followed by Rhizoma Anemarrhenae and Licoroce,Rice had the lowest.When gypsum compatible with other herbs,the calcium ion content of decoction all descend except gypsum and Licorice compatibility group were slightly increased.The calcium ion solubility of gypsum and Baihu Decoction all increased with extend time of soak.But the solubility of calcium ion decreased with boiling time,especially the group of gypsum declined rapidly.ConclusionExcept the content of calcium ion solubility with gypsum and Licoroce group slightly increase,the other compatibility group content of calcium ion solubility all decreased.The content of calcium ion solubility will enable increased with extending the soaking times,and decreased with extending boiling time.


The territorial waters of Hong Kong encompass extensive areas of shallow continental shelf affected by many activities including sand dredging for reclamation fill, disposal of dredged mud, disposal of sewage sludge, commercial fishing, and mariculture. The REMOTS sediment profile imaging camera has been used successfully since 1993 for rapid seafloor assessment to define baseline conditions and impacts on sediment duality during both wet (typhoon) and dry seasons. Several hundred stations have been occupied in a two week survey. Analysis of sediment profile images has allowed assessment of dredging and disposal effects and organic enrichment "hot spots". It appears that tropical storms may have a large effect on mobilization of soft sediments during the wet season, while anthropogenic factors (dredging, disposal, and seabed fishing activities) may assume greater relative importance in some areas during the dry season when severe storms are less common. The soft bottom benthic community consists of a few species of small invertebrates adapted to physical disturbance.