The invention relates to a semiconductor substrate based system (10) for an RFID device (12), particularly for an RFID transponder, comprising a semiconductor substrate (14) and one on the semiconductor substrate (14) constructed electronic circuit arrangement (18). It is contemplated that the semiconductor substrate based assembly (10) further comprises a built also on the semiconductor substrate (14) a thin film battery (22) to power the RFID device (12). The invention further relates to an RFID device (12) with a corresponding semiconductor substrate based assembly (10) and a method for producing a corresponding semiconductor substrate based assembly (10).


Businesses play a potential crucial role in HIV/AIDS prevention and support efforts. Mobilization of corporate resources is especially effective in large geographical regions with emerging markets and limited public resources. In the Asia Pacific region for example the private sector has been actively involved in the traditional public fight against AIDS. Corporate resources such as strategic know-how managerial skills efficient organizational structures manpower and funds are increasingly being utilized to respond to the epidemic. This article focuses on the role businesses can play to address HIV and AIDS in the workplace and the wider community in which they operate. The concept of partnerships between the public and private sector is explained and illustrated with practical examples of the Asian Business Coalition on AIDS. This regional network supported by the Ford Foundation has been created to provide a forum for business managers to exchange ideas about effective strategies for how best to manage HIV/AIDS in the workplace. (excerpt)


e16555 Background: New RECIST 1.1 criteria include more stringent size criteria for lymph node assessment in metastatic disease requiring a short axis measurement of 15 mm for measurable nodes. This change may increase specificity for malignant nodal involvement, at the risk of excluding patients (pts) with lymphadenopathy as the only site of metastatic spread. The aim of our study was to determine how many pts enrolled in RECIST 1.0 trials would not meet eligibility criteria when the new RECIST 1.1 lymph node criteria are applied.

METHODS
Data from 3,470 pts enrolled in 149 trials using RECIST 1.0 for assessment were retrospectively reviewed. Pts with measurable extranodal disease were excluded, as their eligibility would not change. Pts with lymphadenopathy as the only site of metastatic disease were assessed to determine eligibility by RECIST 1.1. Clinical, pathologic, or radiographic information was used to determine whether excluded nodes were malignant. The percent of pts with malignant nodes that would have been excluded by RECIST 1.1 was calculated with 95% confidence intervals (CI).

RESULTS
Of 3,470 pts, 449 (13%) had abnormal nodes as the only site of measurable disease. Using RECIST 1.1, 201 of 449 (45%) pts were ineligible. Of these, 80% (161/201) had malignant or highly suspicious lymphadenopathy according to: 1) lymph node biopsy (n=42); 2) fluctuation of tumor markers correlating with nodal size (n=13); follow-up imaging showing progression +/- new sites of disease (n=40); 4) follow-up imaging showing response with non-target regression (n=9); 5) correlative FDG-PET imaging showing significant FDG uptake (n=14); 6) node in a site typical of spread from the primary malignancy (n=43). Of pts with node-only metastatic disease (n=449), 409 had malignant lymphadenopathy according to our defined criteria: 161 pts had nodes with short axis < 15 mm and 248 pts had nodes ≥ 15 mm, meeting RECIST 1.1 size criteria. Therefore, 39% of pts (161/409, CI: 35%, 44%) with node-only disease would have been ineligible for RECIST 1.1 trials.

CONCLUSIONS
The impact of lymph node size modification in RECIST 1.1 may be substantial on pt accrual for clinical trials using RECIST 1.1; investigators need to be aware of the impact node criteria changes may have on pt enrollment.


The Woodland Advisor program Educates family woodland owners about forest management. To achieve this goal, graduates complete 10 core and 5 elective classes, totaling about 45 hours, and receive a Woodland Advisor certificate; classes have flexible content and schedules for participants to choose; core class include Forest History & Ecology, Forest Health, Woodland Management, Non-Timber Forest Products, Timber Sales, Forest Wildlife, Tree ID, Forest Measurements, and Woodland Financial Management; and graduates help others learn about resources and opportunities for their forestland. Each year we survey Woodland Advisors to learn about their volunteer accomplishments, but response rates were quite low. This year we revised our survey and methodology to obtain a higher response and more useful information.


Total cost of ownership is an important means in purchasing which,with its focus on the long term and on the overall situation,is conducive to the realization of the optimized enterprise cost structure.Yet it is still limited in application by intrinsic constraints,in view of which the paper analyzes these constraints from the perspectives of cost quantization,time value of funds,intra-departmental conflict of interest and capital turnover,with hope to provide purchasing personnel reference for its application.


Fully differential cross section (FDCS) for the transfer excitation (H+ + He → H+He+*) at high proton energies (630 – 1200 keV) is studied both experimentally and theoretically within the simplest Plane Wave First Born Approximation (PWFBA). The role of angular correlations in a trial helium ground state wave function is demonstrated.


Three theoretical models by which social support may influence the impact of stressful life events on cancer patients' psychological state were tested: 1) the additive model, in which social support and stressful life events each directly influence cancer patients' adjustment, irrespective of the magnitude of the other; 2) the buffering hypothesis, in which stressful events occurring in the presence of social support should produce less distress than if they occur in its absence; and 3) both additive and buffering models.


The experiment by the Advanced Research Projects Agency in 1960s led to the foundation of Internet. Internet has now become an integral part of our daily life. From then technologies have progressed from 2G,3G,4G,5G and now even Visible Light. This paper focuses on LI-FI and Developing a new economical optical network communication system for space and water. Light Fidelity is known as LI-FI. LI-FI was first introduced to the world by German Psychist Harald Hass a professor at Edinburg University. [1]LI-Fi is Wireless Optical networking technology that uses Light Emitting Diode (LED) for Data-Communication. Li-Fi is claimed to be 100 times faster than WI-FI. LI-FI provides better bandwidth, efficiency and security than Wi-Fi. In Order for sound to travel there has to be something with molecules for it to travel through, sound needs molecules to vibrate for it to travel. On earth sound travels by vibrating air molecules. In space there are large empty space between planets and stars so there is nothing for molecules to vibrate as a result there is no sound in space. Sound can travel in water but at a speed of 4.3 times faster than in air and also the words and directions are deformed. Li-Fi uses Visible light spectrum and can be developed by blinking LED's at very high speed. Visible Light can travel in


In the process of the intelligent network informatization, automation, and intelligent constantly improving, the requirements of power system for the transparency of the demand side are also getting higher and higher. Real-time and accurate load equipment identification for planning, load forecasting and price adjustment of power system is very important. Electric vehicles has been rapid development in recent years. Because of the characteristics of its battery charging storage, it can be a good part of "cut peak fill in the valley" in the power system. Based on data provided by the smart meters, the electric vehicle charging and discharging characteristics has been analyzed systematically. Conventional electric vehicle charging and discharging transient and steady state parameters as the basic template is used to design load identification method of electric vehicle charging and discharging based on non intrusive.


The Department of Homeland Security is working toward the goal of "a nation prepared with coordinated capabilities to prevent, protect against, respond to, and recover from all hazards in a way that balances risk with resources." This article describes the capabilities-based planning approach to regional and national preparedness.


Purpose: This study was done to examine the relationship between participation motivation, satisfaction and continuance willingness of voluntary activities of nursing students, and to identify factors influencing continuance willingness of voluntary activities. Methods: The research participants wer...


For the space flight mission MESSENGER, the Mercury Laser Altimeter (MLA) instrument required highly reliable optical fiber assemblies for the beam delivery system. A custom assembly was designed based on commercially available technologies to accommodate the requirements for the mission. Presented here are the results of environmental testing the MLA optical fiber assemblies. These assemblies consisted of W.L.Gore FLEX-LITETM cable with 200 micron core Polymicro Technologies optical fiber and the Diamond AVIMS connector kits. The assemblies were terminated to the NASA-STD-8739.5 in the Code 562 Advanced Photonics Interconnection Manufacturing Laboratory at NASA Goddard Space Flight Center. The technology validation methods that were used to characterize these assemblies for usage in a space flight environment have been established and well documented. Only the tests that are known to bring out the failure modes typical to optical fiber assemblies have been performed to assess the ability of these assemblies to withstand the environmental parameters that have been established for Mercury Laser Altimeter. Testing involved vacuum, vibration, thermal and radiation exposure and the data with results of those characterization tests are included here. For the radiation characterization, both the 200 micron core FLEX-LITETM (FON1173) and the 300 micron core FLEX-LITETM (FON1174) were tested. For all other environmental tests only the 200 micron core FLEX-LITETM /AVIMs assembly was tested since it was expected that the results of such testing would not differ much with core size.


56 Background: L1 cell adhesion molecule (L1) is a 200-220 kDa transmembrane glycoprotein of the immunoglobulin super family initially identified in neural cells. L1 was detected in ovarian cancer in a stage-dependent manner, was found exclusively in the invasion front of colorectal cancer, and has been considered a stem cell marker in glioma. The authors have shown that mRNA expression of L1 was a significant prognostic factor in gastric cancer (Kodera et al. Gastrointestinal Cancer Symposium 2009, abst 37). Its role in gastric cancer was further investigated.

METHODS
Expression of L1 was observed by immunostaining in 72 surgically resected pT4A-stage gastric cancer specimens. The association of L1 with peritoneal seeding and prognosis was elucidated. mRNA expression of L1-expressing gastric cancer cell line, KATO3, was suppressed using siRNA (KATO3 L1-). Microarray was used to indentify molecules that differ in expression between KATO3 L1- and the parental cell line.

RESULTS
L1 was scarcely stained in non-cancerous epithelial cells and intestinal metaplastic cells. L1 was detected mainly in the cell surface membrane of cancer cells in 15 of 72 specimens, more often in the intestinal type cancer. No correlation was found between L1 expression and detection of cancer cells in the peritoneal washes or development of peritoneal carcinomatosis. Nevertheless, the prognosis of L1-positive cancer was significantly inferior (p = 0.024). Prognosis was particularly poor among 6 cases where L1 was expressed in cancer cells at the invasive front (median survival time 149 days). Of 40,000 genes evaluated in the microarray, mRNA expression of 50 genes were amplified by > 4-fold whereas the expression of 20 genes were attenuated to less than 1/4. Of these, expression of DYRK1A that induces apoptosis in conjunction with p53 was markedly suppressed to less than 1/8. Suppression of DYRK1A in the KATO3 L1- in comparison with the parental cell line was confirmed by RT-PCR.

CONCLUSIONS
L1 affects prognosis of gastric cancer, particularly when it is expressed in cancer cells at the invasion front. Its role in the biology of gastric cancer has began to be elucidated. No significant financial relationships to disclose.


Courses: Survey of Mass Media, Broadcast Journalism, News Writing, Media Programing, Communication Technology. Objective: Employing the concept of a "hot-clock radio format," the purpose of this unit activity is to motivate students' collaborative learning in news reporting, interviewing, and media programing via smart phones.


Fruits in terms of functional classification are placed under the " protective foods" category.Fruits are rich source of nutrients like vitamins, minerals, trace elements, energy and phytochemicals including flavonoids, polyphenols and antioxidants that have varied health benefits. A fruit juice offers both good health and profound disease risk reduction properties. Juices help to maintain the body's acid-base balance, regulate the functioning of the sweat glands to reduce endocrine acidic waste, preventing skin erosion, making skin white, soft, smooth, delicate, and flexible, and to delay skin ageing. Hence, of late, there has been a growing interest in the therapeutic value of fruit juices and this paper is an attempt to throw light of the health benefits of 6 most regularly consumed fruit and fruit juices.


Isolated spontaneously beating atria from streptozocin diabetic rats were compared with those from controls. Diabetic atria were found to have reduced rates, increased forces of contraction and reduced sensitivity to the inotropic effects of noradrenaline, isoprenaline, tyramine and calcium. Positive chronotropic responses to tyramine were also reduced but those to noradrenaline and isoprenaline were increased suggesting that tyramine releasable stores of noradrenaline were reduced. Elevation of glucose concentration in the medium from 5·6 to 27 min resulted in a decrease of inotropic sensitivity to the agents used in both control and diabetic rat atria. Resting contractile force of control rat atria was reduced by the inclusion of either 22 niM 2‐deoxyglucose, 10−3 i.u. insulin ml−1 or 5 mM acetate in the medium. The rate was also reduced by medium containing 2‐deoxyglucose but increased by insulin. 2‐Deoxyglucose also reduced inotropic but increased chronotropic sensitivity to isoprenaline. Possible mechanisms responsible for the changes observed are discussed.


As it is well known, heritage learners of Spanish have an advantage on oral production and aural comprehension over L2 learners. However, due to their lack of formal instruction in Spanish, their linguistic weaknesses lie on their literacy skills (reading and writing). In terms of writing skills, students mainly struggle with orthography issues (accentuation and spelling) and larger literacy skills (e.g. developing a thesis or organizing ideas). However, there is an important gap in the literature regarding orthographic acquisition since most of the research in the field on focus on form instruction has predominantly been on grammar acquisition (Anderson, 2008; Montrul and Bowles, 2008; Potowski, 2005, among others). In fact, despite the increasing amount of textbooks addressed to this student population with an emphasis on the writing process, to my knowledge there has not been a study on the current approaches of Spanish heritage learners' textbooks for orthography instruction. After analyzing four popular textbooks for Spanish heritage, it can be deduced that the lack of research on this area perpetuates the maintenance of traditional non-communicative explicit instruction of orthography through drills after an explicit explanation of the rules of both accentuation and spelling but new textbooks shed some light towards the implementation of focus on form teaching techniques commonly used in the L2 classroom such as input-output activities.


The deposition of anthropogenic reactive nitrogen (N) in alpine ecosystems can have multiple deleterious effects on plants, soils and hydrology in both the alpine and areas downstream through leaching and export. Thresholds for ecological responses to N deposition have been established for lakes, soils and changes in plant community composition in some areas of the Rocky Mountains. These thresholds offer a target for land and air resource managers to prevent significant changes in ecosystem function, however the underlying feedbacks controlling ecosystem response have not been fully examined. Research originally proposed in association with our UW NPS Small Grant aimed to examine plant to ecosystem interactions within alpine moist meadows between two sites receiving different levels of N deposition. This focus has been modified, in response to site limitations, to examine the mediation of the N cycle by the alpine moist meadow plant community.


Great changes have taken place in Xuanzang's family background in the story of western pilgrimage for Buddhist scripture : from historical to sacred,later to fabulous and simple in the end.These changes are identical with the evolution of the story's gist.The early works mainly extolled Xuanzang's spirits for devoting himself to Buddhism.Later,the popular stories interspersed with poems and songs were chiefly fabricated.Especially the play scripts and fictions of the subject had more trumped-up contents.In the Ming and the Qing dynasties Xi You Ji mainly narrated magic fights of supernatural beings against ghosts and monsters.


A method of micro-mixing-precipitation technology was developed from membrane dispersion technology to prepare ultra-fine TiO2 particles. Titanic sulfate was selected as the dispersed phase, and ammonium acid carbonate as the continuous phase. The influences of the re-actant concentrations and two-phase flow rate were investigated. The crystal structure and crystal dimension of the particles were analyzed by XRD, morphology, particle size and size distribution by TEM. The results showed that the spheric TiO2 nano-particles with small size and narrow size distribution could be prepared with the method. The crystal dimension and the particle size of the Ti02 particles were increased with the increasing of reactant concentrations at first, then decreased. They also were decreased with the increasing of the flow rate of Ti(SO4)2 solution, but increased with the increasing of the flow rate of NH4HCO3 solution.


A packaging and applicator device comprising a receptacle having an interior space (12) wherein the product (P) is contained, an applicator element (16), a housing (14) for receiving the applicator element and a permeable wall (23) disposed between said housing and the internal space containing the application produit.L'element and the housing are arranged so that the present application element, when in said housing, at least one surface portion (16a) located without substantial axial compression, opposite an opening (25) of the wall inside permeable.L'espace is variable volume compression means being provided for selectively passing said interior volume of a first volume greater than the volume of product, to a second volume smaller than the first, this reduction in volume being accompanied by an overpressure which is adapted to promote the transfer of product through said wall pe rmeable or Application to the applicator element element.


In 1985, B.A. Santamaria speculated about the possibility of a new political party in Australia that would be composed of the Nationals, the traditionalist section of the Liberal Party and the "moderate and anti-extremist section of the blue-collar working class".


Objective: To explore the behaviors , causation and the corresponding measures of university fresh men adaptation obstacles. Method: 213 fresh men of recent three years from three colleges who can′t adapt themselves well to university life were observed, talked with and interviewed. The results of consulting about 34 cases, who have the adaptation obstacles were analyzed and deduced. Results: University fresh men adaptation obstacles are found in the following three aspects: the study, social communication and role adaptation and resulted from the interaction of historical culture, stimulation reacting factors and individual quality. Conclusion: Fresh men mental health education should be emphasized greatly and the relevant teaching and administration reform shoud be made.


One aspect of long lasting consequences in the policy of king Alfonso X the Wise is that concerning the urbanization and resetting of the territories of the Castilian Kingdom, which up to the middle of the 13th century had already achieved the territorial expansion that almost with no changes is going to be mantained till 1492. This work looks through the urbanization policy followed by the mentioned king in the Basque Country, particularly in the cases of Vitoria and Mondragon. At the same time, we want to underline some of the data which allow us to state that the growing phase in the Basque urban area went on till the earlier years of the 14th century.


Ethylene-propylene-diene terpolymer (EPDM) was reinforced with different concentrations of Ultra high molecular weight polyethylene chopped fiber (Spectra?m 1000). The reinforced samples were vulcanized using different doses of E-Beam radiation. It was found that E-Beam radiation improves the interfacial adhesion between UHMW-PE fiber and EPDM matrix which was detected by scanning electron microscopy (SEM). In addition the Young's modulus of the composites increases as irradiation dose increases. Increasing the concentration of the fibers up to 40 phr leads to an enhancement in mechanical properties and swelling resistance of obtained composites, especially in the absence of carbon black. In contrast, the tensile strength of EPDM loaded with carbon black decreased as fiber concentration increased even though the other mechanical properties were improved. Although the tensile strength decreased with increasing fiber concentrations, the absolute value of the tensile strength increased by at least three fold with the addition of carbon black.


Three types of expanded shape film-cooling holes were designed to study the change of the film cooling efficiency,heat transfer coefficient at the wall and flow discharge coefficient with the blow ratio.The result shows that: the film cooling efficiency and heat transfer coefficient of the expanded film cooling holes are higher than the typical round film cooling holes,but the flow discharge coefficient is lower.The effect of the streamwise expanded angle on the film cooling effectiveness and heat transfer coefficient is more remarkable than the laterally angle,which expands the area of the low pressure near the edge of the holes,leading to lower flow discharge coefficient.


Voice over Internet Protocol (VoIP) is a way to carry out a telephonic conversation over a data network. VoIP applications, with SIP and RTP, promise converged telecommunications and data services that are cheaper, more versatile and provide good voice quality as compared to traditional offerings. Although VoIP is widely used, VoIP on mobile devices is still in its infancy. Currently, there are number of VoIP solutions for mobile phones, however VoIP solutions developed using Java 2 Platform Micro Edition (J2ME) are not available. Java based solutions are widely compatible with many devices. In this paper strong focus has been given to cross-device compatibility through the use of the widely supported J2ME framework. The design and implementation details of VoIP client using J2ME are illustrated.


On September 21, 2007 in Beijing China, a meeting took place between Mr. Li Changjiang, a top Chinese quality official, Mr. Thomas Debrowski, a senior Mattel executive, and a group of reporters. In what was most certainly a humbling encounter, Mr. Debrowski offered an apology to Chinese toy industry workers and to all of Mattel's worldwide customers who had recently purchased millions of its defective toys. "Mattel takes full responsibility for these recalls and apologizes personally to you, the Chinese people, and all of our customers who received the toys," he said (The Economist, 2007). In fact, Mattel executives and other representatives had been busy for several weeks, apologizing to the U.S. Congress, to Mattel's trading partners, to the American people, and to its worldwide customers for the recalls of over 20 million of its toys during the previous 18 months. Managing the business, ethical, legal, and political fallout caused by the massive toy recalls had become a very expensive and time consuming job for Mattel. By late September 2007, employees had logged over 50,000 hours investigating the issues surrounding the toy recalls. The financial losses due to the recalls were large and mounting--by the middle of October, Mattel reported spending an estimated $40 million on product recall-related activities (Farrell 2007). Ultimately for the year, Mattel reported a four percent decline in U.S. gross sales, compared to an eleven percent increase the previous year and the apparent impact from the 2007 toy recalls had reduced gross profits by approximately $71 million (Mattel Annual Report 2007). Mattel was clearly in a global crisis-management mode. A Brief History of Mattel Mattel began in 1945 and initially became successful making doll house furniture. It was incorporated in 1947, and by 1955, the toy company's annual sales were $5 million. In 1959, Mattel introduced the Barbie doll, the best-selling toy of all time, launching the company to the forefront of the toy industry. The firm became publicly held in 1960 and by 1965 annual sales topped $100 million, placing Mattel in the Fortune 500. In 1968, Mattel introduced its Hot Wheels cars, which quickly became the world's number one die-cast toy vehicles. In that same year, Mattel began acquiring a number of entertainment companies including Ringling Brothers and Barnum & Bailey Circus, a theme park, a publishing company, and a motion picture company. In the early 1970s, Mattel began experiencing some growth problems. In a move purportedly to appease stockholders, executive vice-president and CFO, Seymour Rosenberg, began altering Mattel's books by reporting toy orders as actual sales, even though many orders were never filled. This practice of false sales reporting continued for two years, until 1973, when Mattel reported an unexpected $32 million loss. The loss caused a free-fall in Mattel's stock price and prompted an investigation by the U.S. Securities and Exchange Commission (SEC). Later that year, original Mattel owner, Ruth Handler, along with Rosenberg pleaded no contest to SEC charges resulting from the investigation. In 1974, Rosenberg was fired, and Handler was forced to resign. The company reorganized and returned to profitability in 1977. In the 1980s, Mattel's video games and other non-toy business interests began generating large revenue losses, ultimately resulting in a $394 million loss in 1983 and placing Mattel in danger of bankruptcy. Several venture capital firms stepped in to save the company in 1984, and Mattel sold off a number of subsidiaries to concentrate solely on toys. In the latter 1980s, Mattel renewed an earlier collaboration with the Disney Company and began increasing its international presence by acquiring Hong Kong-based toy company, ARCO Industries; entering into a joint venture with Japanese toymaker, Bandai; and acquiring French doll manufacturer, Carolle S.A. and British die-cast toy car maker, Corgi Toys Ltd. …


The aim of this study is to examine the number sense skills of preservice elementary school mathematics teachers. This study was conducted by using the survey model among descriptive research methods. A total of 111 preservice teachers studying at second and third grades in the elementary school mathematics teaching program at a state university participated in the study. The data of the study were collected by using the number sense test consisting of 17 questions and developed by Kayhan-Altay (2010). The findings of the study indicated that the number sense performances of preservice elementary mathematics teachers were lower than expected and there was a significant difference in favour of third-grade students. It is considered that the "Special Training Methods I and II" courses and the "Mathematics Curriculum" course, which are taught in third grades and in which subjects such as estimation and making mental calculations, etc. superficially related to number sense are mentioned, may cause this difference. Thus, it was suggested that it was necessary to include courses consisting of number sense and how it can be developed in the curriculum.  Article visualizations:


The present invention relates to a method for analyzing a computer executable application object, comprising a step for connecting a control object and the application object and executing the control object; a step for analyzing the application object by using the control object and extracting a screen composition element defined in the application object; and a step for detecting an event function by identifying an event for the screen composition element and monitoring an executing process of the application object based on the unit of the detected event function. Therefore, the service flow for a test object application can be extracted.


Abstract Tacrolimus has proven to be superior to cyclosporine‐Sandim‐mune with regard to the prevention of acute rejections, but data comparing tacrolimus with Neoral are scarce. A total of 128 consecutive renal transplant recipients was studied. The patients were treated with Neoral‐based (n= 74) or tacrolimus‐based (n= 54) immuno‐suppressive regimens. Survival analyses (Cox regression analysis) were performed on an intention‐to‐treat basis. Renal function and cardiovascular risk profile were analyzed by means of a repeated‐measures analysis of variance (ANOVA) up to 12 months after transplantation. Immunological features were less favorable in the tacrolimus group. Two‐year patient and graft survival were comparable. Acute‐rejection‐free survival was 82% in the tacrolimus group versus 40% in the Neoral group (p < 0.0001). The severity of the rejections (1997 Banff classification) was comparable (P= 0.43). Immunological graft loss (3.7% vs 12.2%, P= 0.02) and conversion because of rejection (0% vs 28.4%, p < 0.001) were less in the tacrolimus group. A higher proportion (68.5% vs 14.9%, p < 0.001) was successfully put on monotherapy. Creatinine clearance, proteinuria, and fractional uric acid clearance were similar. In the tacrolimus group mean blood pressure was comparable, but patients needed less antihypertensive drugs (p < 0.001) and, even with fewer patients on lipidlowering drugs, total cholesterol was lower (5.2 vs 6.0 mmol/l, P= 0.003). Treatment for post‐transplant diabetes mellitus was 18.5% versus 10.8% (P= 0.22). In both groups, antidiabetic medication could be withdrawn for most patients. This study indicates that tacrolimus is superior to cyclosporine‐Neoral in preventing acute rejection with comparable patient and graft survival rates. Because of a lower need for treatment of hypertension and hypercholesterolemia, the cardiovascular risk profile is more favorable. A considerable proportion of patients can be successfully weaned off co‐medication and treated with tacrolimus monotherapy.


Short Message Service (SMS) remains one of the most popular communication channels since its introduction in 2G cellular networks. In this paper, we demonstrate that merely receiving silent SMS messages regularly opens a stealthy side-channel that allows other regular network users to infer the whereabouts of the SMS recipient. The core idea is that receiving an SMS inevitably generates Delivery Reports whose reception bestows a timing attack vector at the sender. We conducted experiments across various countries, operators, and devices to show that an attacker can deduce the location of an SMS recipient by analyzing timing measurements from typical receiver locations. Our results show that, after training an ML model, the SMS sender can accurately determine multiple locations of the recipient. For example, our model achieves up to 96% accuracy for locations across different countries, and 86% for two locations within Belgium. Due to the way cellular networks are designed, it is difficult to prevent Delivery Reports from being returned to the originator making it challenging to thwart this covert attack without making fundamental changes to the network architecture.


This chapter gives an introduction to first-principles electronic structure calculations based on the density functional theory (DFT). Electronic structure calculations have a crucial importance in the multi-scale modelling scheme of materials: not only do they enable one to accurately determine physical and chemical properties of materials, they also provide data for the adjustment of parameters (or potentials) in higher-scale methods such as classical molecular dynamics, kinetic Monte Carlo, cluster dynamics, etc. Most of the properties of a solid depend on the behaviour of its electrons, and in order to model or predict them it is necessary to have an accurate method to compute the electronic structure. DFT is based on quantum theory and does not make use of any adjustable or empirical parameter: the only input data are the atomic number of the constituent atoms and some initial structural information. The complicated many-body problem of interacting electrons is replaced by an equivalent single electron problem, in which each electron is moving in an effective potential. DFT has been successfully applied to the determination of structural or dynamical properties (lattice structure, charge density, magnetisation, phonon spectra, etc.) of a wide variety of solids. Its efficiency was acknowledged by the attribution of the Nobel Prize in Chemistry in 1998 to one of its authors, Walter Kohn. A particular attention is given in this chapter to the ability of DFT to model the physical properties of nuclear materials such as actinide compounds. The specificities of the 5f electrons of actinides will be presented, i.e., their more or less high degree of localisation around the nuclei and correlations. The limitations of the DFT to treat the strong 5f correlations are one of the main issues for the DFT modelling of nuclear fuels. Various methods that exist to better treat strongly correlated materials will finally be presented.


Ionic species can be stabilized in the water core of a
water-in-CO2 microemulsion in supercritical fluid
CO2; by mixing two microemulsions containing Ag+ and
X− ions separately, silver halide (AgX) nanoparticles were
synthesized in supercritical CO2; the water-in-CO2
microemulsion may provide a reaction system for a wide range of
nanoparticle syntheses involving ionic species in supercritical
CO2.


The effects of a keratin promoter on the expression of mouse tyrosinase in various cultured cell types via retroviral infection Sub Title Author Frew, Tim(Yamamoto, Hiroaki) Whitaker, Beth(Akiyama, Toyoko) Brumbaugh, John 山本, 博章 秋山, 豊子 Publisher 慶應義塾大学日吉紀要刊行委員会 Publication year 2017 Jtitle 慶應義塾大学日吉紀要. 自然科学 (The Hiyoshi review of natural science). No.61 (2017. 3) ,p.117 Abstract A retroviral vector was constructed containing a cDNA for mouse tyrosinase under control of a modified (with intron removed) chick feather keratin promoter. Cultured chick embryo keratinocytes infected with this vector showed bright fluorescent labeling with an antibody (T1) specific to mouse tyrosinase, but did not produce visible pigment. Cultured chick embryo fibroblasts infected with the vector also showed positive fluorescent labeling with the T1 antibody, but the labeling appeared less bright than that seen in infected keratinocytes. Cultured albino (ca/ca) melanocytes infected with the vector developed dark, discrete pigment granules. Mock infected keratinocytes, fibroblasts, and melanocytes had little or no background immunofluorescence when labeled with T1. Chick hepatocytes infected with the keratin vector could not be distinguished from mock infected hepatocytes cultures, even by T1 labeling. These results suggest that the modified keratin promoter imparts partial tissue specificity to genes under its control. The tyrosinase expression seen in keratinocytes, and the pigment production seen in albino melanocytes infected with the keratin vector may make it a vector useful for tagging gene transfer in albino chickens. Notes 原著論文 Genre Departmental Bulletin Paper URL http://koara.lib.keio.ac.jp/xoonips/modules/xoonips/detail.php?koara_id=AN10079809-20170331 -0001


Cyclization of the linear peptide 5 prepared by coupling a suitably β-amino acid 1 with N-protected L-Ala yielded 2,5-imidazolidinedione 6.


A complex test program, such as the Defense Advanced Research Projects Agency Autonomous Minehunting and Mapping Technology, (AMMT), demands detailed test planning. The AMMT Master Test Plan met this requirement. The plan prepared the test team for five months of field work and still preserved flexibility for unanticipated contingencies.


Simulation is a strong tool for traffic engineers to investigate phenomena, to test control strategies and their impacts, but it also has its limitations. The data needed to calibrate the simulation is limited, mostly from low quality, or - when looking into behavior - not available at all. For the latter on, methods ranging from simple surveys to highly technical experiments in driving simulators are used. The trade off is between the number of people a survey/experiment reaches and the level of realism one can generate to get accurate information. In this paper we are introducing a behavior studies platform based on 3D Internet that will allow researchers to reach out to a broad audience with a high level of realism, but limited technical effort. The system is now in the final testing stage before being utilized to test drivers' reactions on intelligent traffic system (ITS) measures to reduce the emission of CO2.


The continued device scaling in the semiconductor industry has resulted in an acceleration of the respective technology roadmaps worldwide, which in turn is reflected in the constant pull-in of the lithography roadmaps. From the lithography toolmaker point of view this situation had to be answered with a consistent integrated equipment development roadmap. The general toolkit philosophy of the Leica ZBA300 family of E- beam systems incorporates such features and results in a harmonization of the development and usage of e-beam tools over a wide range of device generations. The theoretical advantages of shaped beam systems over raster scan in terms of edge definition as well as in terms of writing times become especially obvious when advanced masks with the emerging reticle enhancements like OPC are taken into account. It is the successful application of such techniques that will make the production of reticles for the 0.18 micron generation and below a commercially feasible enterprise.


This paper presents a storage system that can hide the presence of hidden data alongside a larger volume of public data. Encryption allows a user to hide the contents of data, but not the fact that sensitive data is present. Under duress, the owner of high-value data can be coerced by a powerful adversary to disclose decryption keys. Thus, private users and corporations have an interest in hiding the very presence of some sensitive data, alongside a larger body of less sensitive data (e.g., the operating system and other benign files); this property is called plausible deniability. Existing plausible deniability systems do not fulfill all of the following requirements: (1) resistance to multiple snapshot attacks where an attacker compares the state of the device over time; (2) ensuring that hidden data won't be destroyed when the public volume is modified by a user unaware of the hidden data; and (3) disguising writes to secret data as normal system operations on public data. We explain why existing solutions do not meet all these requirements and present the Ever-Changing Disk (ECD), a generic scheme for plausible deniability storage systems that meets all of these requirements. An ECD stores hidden data inside a large volume of pseudorandom data. Portions of this volume are periodically migrated in a log-structured manner. Hidden writes can then be interchanged with normal firmware operations. The expected access patterns and time until hidden data is overwritten are completely predictable, and insensitive to whether data is hidden. Users control the rate of internal data migration (R), trading write bandwidth to hidden data for longevity of the hidden data. For a typical 2TB disk and setting of R, a user preserves hidden data by entering her secret key every few days or weeks.


This paper analyses the performance of the time domain reflectometry (TDR) technique when it is applied to the location of faults on cables. Different types of defects, which can arise on coaxial cables, are modelled and their reflection coefficients are calculated. The results, validated by experimental data, are compared to the typical noise that affects this kind of measurement to assess the sensitivity of the technique. Shield damage to a shielded twisted pair and a shielded multiwire cable is also examined: these examples represent more critical situations because the effect of cable and mismatching losses limits the dynamic range of the measurement.In both cases, the TDR allows us to locate faults that strongly affect the propagation of the signal on the transmission line, but the reflections produced by small defects are often masked by the noise. A data processing technique based on the comparison with a reference measurement and the use of the statistical correlation are then implemented. In this way, the reflections produced by the faults are much more visible and an overall enhancement of the technique sensitivity is achieved.


All illness represents a state ofdiminished autonomy and therefore the doctor-patient relationship necessarily and justifiably involves a degree ofmedical paternalism argues the author, an American medical student. In a broadranging paper he discusses the concepts ofautonomy and paternalism in the context of the doctor-patient relationship. Given the necessary diminution ofautonomy which illness inflicts, a limitedform ofmedical paternalism, aimed at restoringormaximisingthe patient's autonomy is entirely acceptable, and indeed fundamental to the relationship he argues. However, the exercise ofthis patentalism should be flexible and related to the current 'level ofautonomy' of the patient himself. An editorial in this issue comments briefly on this paper.


The pace of coatings development is limited by the time required to assess their corrosion protection properties. This study takes a step f orward from Part I in that it correlates the corrosion performance of organic coatings assessed by a series of short-term electrochemical measurement with 18-month beachside exposure results of duplicate pan els. A series of 19 coating systems on A36 steel substrates were test ed in a completely blind study using the damage tolerance test (DTT). In the DTT, a through-film pinhole defect is created, and the electro chemical characteristics of the defect are then monitored over the ne xt 4 to 7 days while immersed in 0.SM NaCl. The open circuit potentia l, anodic potentiostatic polarization tests and electrochemical imped ance spectroscopy were used to study the corrosion behavior of the co ating systems. The beachside exposure tests were conducted at the Ken nedy Space Center according to ASTM D610-01. It was found that for 79 % of the coatings systems examined, the 18 month beachside exposure r esults could be predicted by two independent laboratory tests obtained within 7 days.


This paper examines the potential role of mindfulness in the cultural intelligence (CQ) literature. Mindfulness is examined through three key facets: empathy, open-mindedness, and using all senses. Based on a literature review, propositions are developed on potential relationships from mindfulness to CQ cognition and CQ behavior.


A simulation system of distribution network design and development based on similarity principle is introduced. This simulation system includes primary simulation system and secondary control system, the primary system simulates a 10kV neutral indirectly earth distribution system, which includes a bus, four feeders with different types and different length. System structure and parameter calculation principle are introduced. The secondary control system includes simulated circuit breaker control system and fault setting control system. Switching equipments can be controlled by local button or remote compute to change the system operating status and fault settings. The simulation system has been completed and operates well in power system dynamic simulation laboratory.


The development of composite materials with excellent thermal conductivity is attracting extensive attention to meet the increasing heat concentration challenges in both power and electronic equipment. Previous strategies for improving the thermal conductivities usually accompanied by the cost of mechanical strength. Herein, we propose a new strategy for developing both mechanically strong and thermally conductive composite films. The aramid nanofibers (ANF) are well prepared with introducing Ag nanoflakes and graphene oxide (GO) via vacuum-assisted filtration and hot-pressing treatment. Results indicate the synergistic effects of low dimension materials have resulted in a tightly arranged phonon network construction. The in-plane thermal conductivity of the prepared ANF/Ag/GO film reaches 9.84 W m−1 K−1, about 371% higher than that of pure ANF. Meanwhile, the strong hydrogen bond formed between the functional group of GO and the amide group of ANFs plays a synergistic strengthening and toughening role at the complex interface, and the tensile strength reaches 231 MPa. We believe that these findings shed some light on the design and fabrication of multifunctional materials for thermal management applications.


One of the most frequent infectious diseases in nosological structure of the neonatal period is pneumonia. The newborns who are on the artificial pulmonary ventilation (APV) get into risk group on development the ventilator-associated pneumonia (VAP) which frequency increases in process of increase in duration of APV. It is established, that newborns, being on APV in most cases have a microaspiration of gastric contents that does relevant the purpose of the real research: studying of influence of APV and a microaspiration of gastric contents on the frequency of development and feature of a course of neonatal pneumonia. Materials and methods. The research included 177 newborns receiving respiratory therapy. The ex-pressiveness of a microaspiration was estimated on the basis of definition of Pepsinum in a tracheobron-chial aspirate (TBA). The diagnosis of VAP was established on the basis of reference clinical and radio-logical criteria. Main results of a research. It is established that the newborns who are on the APV with "rigid" parameters had more frequent cases of pneumonia with the expressed microaspiration of gastric contents. Patients with a combination of a microaspiration and pneumonia had the maximal duration the APV and the subsequent kislorodoterapiya. In a genesis of heavy respiratory frustration in the neonatal period with requirement in the APV with "rigid" parameters contamination of respiratory tracts a Gram-negative microflora, presumably intestinal origin had the greatest statistical


Epoxy diane oligomer ED-20, 2,4-diaminoazobenzene-4'-carboxylic acid modifier, polyethylene polyamine hardener,microdispersed particles of synthesized powder charge and a mixture of discrete fibers were used to form composite materials and protective coatings for the transport industry. The influence of aggressive media: oil, gasoline, sea water, acetone, NaOH (50 %), HCl (10 %) and H2SO4 (10 %) on the corrosion resistance of the developed composite materials with different content of ingredients was studied. The results of experimental studies suggest that the least swelling was observed for samples of composite containing components in the following ratio – modified binder: microdisperse filler in the form of a synthesized powder charge (Fe (70 %) + Ti (10 %) + TiC ) + Fe3C (5 %)) (d = 10–12 mm) : mixture of discrete fibers (modal (42 %), polyacrylic (38 %), polyamide (38 %)) – 100 : 0.05 : 0.10. The use of such a composite in the form of protective coatings of vehicles will ensure (if compared to the modified epoxy matrix) reduction of the permeability of aggressive media in: 1.5–1.7 times (when being used in oil and gasoline); 1.6–1.8 times (when being used in seawater, acetone and NaOH solution (50 %)); 3.0 and 2.5 times (when being used in solutions (10 %) of hydrochloric and sulfuric acids, respectively. Increased corrosion resistance compared to the matrix is caused by a decrease of the amount of polymer in the developed material and its increased cohesion strength, which increases the path of penetration of molecules of corrosive agents during their diffusion into the composite due to additives.


ment was seen between age groups. The antibiotic was given as monotherapy (66%) or in combination with another antibiotic (34%). Cycloplegics were given in 42 cases, and topical corticosteroid was added during follow-up in 24 cases. Surgical adjunctive therapy was provided in seven cases: crosslinking (4), amniotic membrane transplantation (3), conjunctival flap (1) and evisceration (1). Two cases had both an amniotic membrane transplantation and underwent cross-linking. Four patients were hospitalized due to lack of treatment response, insufficient compliance or threatening corneal perforation. A causative agent was identified in three cases that required surgical therapy. In the eviscerated eye, staphylococcus aureus was identified in a conjunctival smear. Initial VA ranged from amaurosis to Snellen 30/20. In 90% of cases, preserved or improved VA was observed at the last follow-up visit. An improvement in VA was seen in three of the four patients that underwent crosslinking. In conclusion, the epidemiologic data in this study are in line with previous reports (Schaefer et al. 2001; Bourcier et al. 2003). The majority of cases were successfully treated empirically. Overall, observed clinical care adhered to the AAO recommendations (AAO 2013) including choice of firstin-line antibiotic. However, corneal scrapings for culture could be taken more frequently, especially in cases of severe keratitis.


Objective:To investigate the changes of calcium, phosphorus and zinc of rabbit in the experimental model of stress fracture. Methods:a rabbit experimental model of stress fracture was set up, and diagnosis was done according to the result of ECT(Electronic Computerized Tomography). During 6 weeks' test, 6 rabbits as control group, and 8 rabbits were stimulated to run or jump in a special device as experimental group. At the end of training, rabbits were sacrificed for the determination of element of calcium, phosphorus and zinc. Results:①The zinc in the serum from experimental group are more higher than that from the control group, though the element of calcium, phosphorus, parathyroid hormone, calcitonin, osteocalcin in the serum showed no difference between the experimental and control group. ②The element of calcium and zinc in the skeletal muscle from the experimental group were much higher than that from the control one. But the element of calcium and zinc in the liver showed no difference between the experimental and control group, Conclusion:The results indicated that the element of calcium and zinc might play some roles in the occurrence of the experimental stress fracture.


The continuity of electrical energy requires an electric energy management with high efficiency and easy-to-obtain fuel. One of them is the Ombilin Steam Power Plant (PLTU) with a capacity of 2 x 100 MW. At ombilin power plant there is a system of its own use that is obtained from the generator when the plant is operating. In this study, contingency analysis was conducted on its own system simulated using ETAP 12.6 software. Contingency analysis is the study of the safety of an electric power system by conducting a power flow analysis of the impact of a number of contingency cases such as the release of one or more generators and the release of one of the tramsmission elements. With contingency analysis, an electric power system will be able to calculate the disruption that occurs for example in the use of a power plant unit, so that it can predict changes in system capacity and the remaining bus voltage whether it can still be burdened or has experienced overload conditions. In this study, a contingency analysis was conducted on the Ombilin PLTU's own usage system with 5 scenarios to see the results of voltage and performance index (IP) when contingencies occurred with 5 scenarios then ranked. Based on the results of 5 scenarios, the highest voltage obtained in scenario-3 is 6.18 kV with a performance index (IP) of 2.4915 and the lowest voltage in scenario-4 is 6.13 kV with a performance index (IP) of 3.1526.


Meghalaya is a tiny state carved out from the state of Assam. In the present investigation status of traditional cottage level handloom units of West Garo Hills districts of Meghalaya was observed critically in terms of infrastructure, economic standard, work and skill level of workers, condition of tools and equipments used in the unit, various motifs and colours combinations etc. it was concluded that weavers of Garo Hills are making very good handloom products. But these products are unexplored out of Garo hills, so that there is a need to explore and revive these handloom products out of Garo hills. They were several traditional weaving culture using indigenous looms and traditional designs. Now, there is a need to revive this weaving culture by using latest and fast looms and new designs to compete in today's world of fashion.


Objective
To investigate the role of spinal hyperpolarization-activated cyclic nucleotide-gated (HCN) channels in dexmedetomidine-produced antinociceptic effect.

Methods
In vivo experiment Thirty wild type C57BL/6J mice and 30 HCN1 gene knockout (HCN1-/-) mice, aged 2-3 months, weighing 19-25 g, were randomly divided into 5 groups (n=6 each) using a random number table: control group (group C), and dexmedetomidine 10, 20, 30 and 40 μg/kg groups (Dex10, Dex20, Dex30 and Dex40 groups). In Dex10, Dex20, Dex30 and Dex40 groups, dexmedetomidine 10, 20, 30 and 40 μg/kg were intraperitoneally injected, respectively.The equal volume of normal saline was given in group C. Before dexmedetomidine administration, and at 15, 30, 45, 60, 75, 90, 105 and 120 min after dexmedetomidine administration, tail flick latency to a thermal nociceptive stimulus was measured, and the percentage of the maximum possible effect (MPE%) was calculated.In vitro experiment HCN1 and HCN2 plasmids and green fluorescent plasmids were transfected into HEK293 cells with liposome 2000.At 24-48 h after transfection, HCN1 and HCN2 channel currents were recorded using whole-cell patch clamp technique.HCN channel currents were recorded as baseline value after rupture of membrane.HEK293 cells were perfused with the extracellular fluid containing different concentrations of dexmedetomidine (0.1, 1.0 or 10.0 μmol/L). After the cells were perfused with dexmedetomidine 0.1 μmol/L for 5 min, HCN currents were recorded.The inhibition rate of currents were calculated.After washout, HCN currents were recorded after the cells were perfused with the next concentration for 5 min.The half-maximal activation voltage (V1/2) of HCN channels and the curve slope were recorded.The difference in V1/2 before and after administration (△V1/2) were calculated.

Results
Compared with group C, MPE% was significantly increased in Dex10 group-Dex40 group of wild type and HCN1-/- mice (P 0.05). Compared with the baseline value, the currents and V1/2 of HCN1 and HCN2 channels in HEK293 cells were significantly decreased when the cells were perfused with dexmedetomidine 0.1, 1.0 and 10.0 μmol/L (P 0.05).

Conclusion
Dexmedetomidine-produced antinociceptic effect is likely related to the inhibition of spinal HCN channel opening.

Key words:
Dexmedetomidine; Cyclic nucleotide-gated cation channels; Analgesia; Spinal cord


We have derived the unitarity bounds in the high energy limit for the minimal B-L extension of the standard model by analyzing the full class of Higgs and would-be Goldstone boson two-to-two scatterings at tree level. Moreover, we have investigated how these limits could vary at some lower critical value of the energy.


The specific heat capacities at constant pressure of alkaline sodium aluminate solutions in NaOH-NaAl(OH)4H2O system were determined using a commercial calorimeter(Setaram C80) at temperatures ranging from 298.15 K to 363.15 K and constant pressure,where the total alkli molality mT(mNaOH+mNaAl(OH) 4) and αK(mT/mNaAl(OH)4) are 0.88 6.16 mol/kg and 1.9 5.0,respectively.The equation of the specific heat capacity as a function of total alkalinity,αK and temperature was constructed for sodium aluminate solution.The error between the results calculated from this equation and experimental values derived from the literature is 0.014.The apparent molar specific heat capacities(cpΦ) for sodium aluminate solution were also calculated,and the results show that the apparent molar specific heat capacities(cpΦ) have a maximum value with the temperature increasing,and that cpΦis linear varied with the values of 1/αK.


This article selects GEM(Growth Enterprise Market) companies as the research object, intercepts the data since the establishment of the GEM board in 2009, and analyzes the relationship among corporate accrual earnings management, real earnings management, media supervision, and exit threats. It was found that media supervision would inhibit the accrued earnings management behavior of GEM companies, but the exit threat would increase the company's accrual earnings management behavior. As for the real earnings management ,the media supervision has motivated the company to adopt more secret real earnings management behaviors, while the exit threat will inhibit its true earnings management behavior. In addition, in the act of accrual earnings management, media supervision and exit threats have an alternative relationship. But in real earnings management behavior, the two are complementary.


Availability of irrigation water is often the limiting factor in the establishment of improved pastures in the U.S. Intermountain Region, and grasses used for pasture should have enhanced water-use efficiency (WUE). Objectives of this study were to describe (i) relationships between carbon isotope discrimination (Δ) and dry matter (DM) yield, and (ii) trends in Δ across four water levels (WL 2, wettest, to WL 5, driest) and two harvest dates under frequent defoliation in cultivars of orchardgrass (Dactylis glomerata L.) perennial ryegrass, (Lolium perenne L.), intermediate ryegrass (L. ×hybridum Hausskn), and festulolium [×festulolium braunii (K. Richt.) A. Camus.]. Within all WLs, orchardgrass cultivars exhibited higher WUE than the ryegrasses, which includes intermediate ryegrass and festulolium. Significantly more variation for Δ within WLs was observed in the ryegrasses than orchardgrass. For orchardgrass, DM yield and A were not correlated at WLs 2 to 4. However, they were negatively correlated at WL 5. Correlations between A and DM yield were not significant at WLs 2 and 3 for the ryegrasses, but were positive at WLs 4 and 5. To avoid possible declines in DM yield in breeding programs to increase WUE in orchardgrass and the ryegrasses, DM yield should also be monitored.


One hundred-fifty participants were interviewed about their social networks. Demographic measures and an index of social desirability were also obtained. A multiple regression of these variables against the number of outpatient psychotherapy sessions attended was computed. A statistically significant model accounting for 14% of the variance emerged. Despite the low proportion of variance accounted for by the model, a canonical coefficient accurately predicted attendance at only one therapy session 74.4% of the time. These data lend credence to the notion that the social network may exert an important influence on the utilization of mental health services. It further appears that specific areas or functions served by the network have differing influences on the individual. Implications for program development and service delivery are discussed.


The experimental study of pressure leaching of lead matt was described in this paper. Various factors affecting leaching rate of copper,zinc were investigated,acidity,reaction time,pressure,grinding time and liquid-solid ratio included. The experimental results show that under the appropriate leaching conditions,the leaching rate of copper and zinc reach 97. 17% and 95. 78%while lead,tin and silver are mainly stayed in the leaching residue. Ratios of comprehensive utilization of mineral resources are improved.


In 1984, the historical-geographer Arthur Steegh (1946-2005) drew a fictive map that included most landscape types of the Netherlands. The map could be used to simulate the effects of planning procedures on landscapes and was part of a report on the use of landscape data in Environmental Impact Assessments. Steegh situated his map in the municipality of Juinen, which was the – again fictive – location for a popular satirical programme on Dutch television.


Pharmacovigilance is science and activities relating to the detection, evaluation, understanding, and prevention of adverse reactions to medicines or any other medicine-related problems.Regulatory requirements for Pharmacovigilance in different countries are varying from each other so it is challenging for companies to develop and making pharmacovigilance requirement and comply with the requirement of different countries. The objective of this work to compared the regulatory requirement of pharmacovigilance in Europe and Malaysia. It also helps to understand the regulatory requirement in relation to pharmacovigilance in regulated (Europe) and semi regulated country (Malaysia). This article mainly focuses on pharmacovigilance guideline related to adverse drug reaction (ADR),Periodic Safety Update Report (PSUR); and Risk Management system in Europe and Malaysia.


SUBTITLE: FAA'S AVIATION HUMAN FACTORS GURU TALKS ABOUT HIS AGENCY'S AMBITIOUS NEW PROGRAM TO APPLY THE FRUITS OF HUMAN FACTORS RESEARCH THROUGHOUT THE AIR TRANSPORTATION SYSTEM


Within the key elements in relation to gender identity formation, the violence culture constitutes the axis from which masculinity (to be male) and feminity (to be female) builds up in Venezuela. This Work analyses from an interdisciplinary point of view (Sociological and Psychological), in the first place, data from empirical research collected in Merida (90-97), showing a particular violence towards the men who generally practice it and live it within the privete space. In the second place, we made a qualitative analysis based on the differential socialization method dichotomicaly internalized by men and women under our socio-cultural milien. Finally, we present a proposal of education for equality and for the development of a violence free culture


In order to solve problems of slowness of emergence of seedling in cultivating plants in spring, an irregular emergence of sedlings ,lack of sprout and the influence of production ,the authors use a way of dividing roots to cultivate and to use plastic films in coueriny to conduct a comparative experiment of factors such as: temperature of the soil ,moisture of the soil ,nutrition of the soil; time ol seedling and rate of seedling. As a result, the ellect ol ecology of Salvia miltiorrhiza after being covered by plastic films is rery obvious ,and the production is clearly higher than the comparative group of seedling on open plots.


This paper explores the roles and responsibilities of business toward protecting the natural environment as a mean to create and maintain business sustainability from an Islamic perspective. The ultimate aim of a business is to maximize profit within the legitimate means, which is the bottom line of a business. The business greediness to pursue maximum profitability has contributed significant degradation of the natural environment, global warming and the reduction of greenhouse gases. This situation leads to negative consequences to the human and non human well being as well as business sustainability. A business is sustainable when it secures its profitability interest along with protecting the interest of the stakeholders and the natural environment. Hence, policy makers and business leaders formulated policies and programs to protect and preserve the environment from further degradation to protect and preserve business sustainability. However, many countries and major industry players are reluctant to participate in the programs. The study offers an integrative framework of business, the natural environment and sustainability from Islamic perspective, with a special reference to the Islamic Jurisprudence of the environment (Fiqh al-Bi'ah fi al-Islam) by Mustafa Abu-Sway, particularly the relationship between human beings and the environment (vicegerency, subjection, and inhabitation). Since the nature of the study is explorative, the research design fits into the constructionism research paradigm. The use of qualitative personal interview with the relevant informants provide rich insights to the objective of the study. The study used note taking approach in the personal interview with 35 respondents, which comprised five policy makers, 10 business leaders, and 5 community leaders in Malaysia and Thailand to provide the insights on the roles and responsibilities of business sectors toward protecting the natural environment and whether they are convinced that this approach contributes to business sustainability. The results of the study showed insignificant difference despite different geographical and political administration between Thailand and Malaysia. Policy makers from both countries were convinced that business sectors should include the natural environmental protection agenda into the business policies as part of the corporate social responsibility. The community leaders from both countries concurred with the policy makers that the business sectors should be more proactive in protecting the natural environment despite the ultimate business responsibility. Nevertheless, business sectors disagreed to burden the business solely with the responsibility to protect the natural environment as the duty to protect the natural environment is collective duties and responsibilities. In fact, business managers have to fulfill economic and legal responsibilities to maximize the value of the shareholders. The feedback from the informants suggest that policy makers, community leaders and business owners should revisit two duties and responsibilities to protect the natural environment and business sustainability, namely "subjection" and "inhabitation." However, the results are not generalizable due to inadequate insights about the duties and responsibilities to protect the natural environment and to gain sustainability in business from Islamic perspective


In American English, voiceless codas /t, p/ are often realized with glottalization on the preceding vowel. Previous claims suggest that such glottalization can serve to enhance /t/ or, more generally, voicelessness of coda stops. This study examines the timecourse of word recognition to test these claims. 40 American English listeners participated in an eye-tracking study, where they heard synthesized glottalized and non-glottalized versions of CVC English words ending in /p, t, b, d/ while looking at a display with two words presented orthographically. Target words were presented with a minimal pair differing in place of articulation (e.g., cop-cot), or voicing (e.g., bat-bad, cap-cab). Our results indicate that listeners fixated to target words ending in /t/ marginally faster when they heard the glottalized version and when the competitor presented was a word ending in /p/. Glottalization did not result in faster fixation to targets for words ending in /p/. We also found a strong inhibitory effect—lower...


A Test and troubleshooting system for fuel pump is described.It is developed by OOT(objectoriented technology).It is convenient for a programmer to analyze and design the test and troubleshooting system by the method of OOT.The fuel pump rig test and troubleshooting system can achieve its purpose of test and troubleshooting by monitoring the working performance and parameter of the fuel Pump.


Delivering a low-carbon economy puts ourselves on a path to cut CO2 emissions,which is the main contributor to global warming. Developing low-carbon technology in electricity industry will play an important role in helping us to be prepared for the low-carbon economy in the future since electricity always being the biggest emission source. In this paper,after describing features of CO2 emissions and corresponding reduction potential in China's electricity sector,main difficulties and challenges in creating a low-carbon electricity industry in China are analyzed. On this base,a research framework is established,giving out a comprehensive prospect on the future development of electricity technology in a low-carbon scenario,which deeply reveals new research trends and interests of this area.


Theoretical considerations and previous experimental findings with fast tubular (cylindrical sheet) pinch discharges are reviewed briefly. More recent work with magnetic probes, as well as streak and Kerr cell photography, corroborates that the sheet‐current configuration can be sufficiently stable to survive a fair number of pinch oscillations. It is shown, however, that under conditions of high compression the current layer is likely to break up into a set of individual channels because of a resistive instability. The process involves tearing and reconnection of magnetic field lines. Wavelengths and growth rates seem to be in agreement with rough theoretical predictions. The current channels form separate linear pinches, which under certain circumstances disintegrate subsequently by a secondary instability. A generally turbulent behavior results. Tearing is not prevented by superposition of a strong axial magnetic field, again in agreement with theory, although a slight retardation is noted. When deuterium is used in the discharge, neutrons are emitted. Presumably because of the slow rate of reconnection in most of our studies, the neutrons appear mainly during the secondary instability, rather than at the time of tearing. These findings are of interest both to astrophysics and to controlled‐fusion research.


One of the key concerns of midwives regarding statutory midwifery supervision has been the conflicting role of supervisor and manager (Isherwood, 1988; Flint, 1993; Kirkham, 1994; Walton, 1995). The debate centres on whether an individual should undertake the dual role of supervisor and manager, an arrangement that can result in the blurring of boundaries between the roles and in consequence dissonance for midwives. This study was undertaken to determine midwives' views of supervision in a local maternity unit when supervision was in the process of being evaluated. The aim of the review was to increase the profile of supervision and of supervisors within the local maternity unit, by assessing the views of midwives on a number of key issues.


We investigate bank holding companies' window dressing of quarter-end short-term borrowings. We find evidence of downward window dressing of short-term borrowings through repo and federal funds that appears material for a large fraction of the sample. Such downward window dressing is more pronounced at banks with higher leverage, lower capital adequacy ratios, and greater management compensation sensitivity to ROA and ROE. Consistent with this downward window dressing being a net detriment to equity holders, we document a negative equity market reaction to the release of regulatory filings that indicate unexpected downward window dressing in these accounts. Finally, we find evidence of window dressing of short-term borrowings within private banks, suggesting that non-equity market considerations provide key window dressing incentives. The potential implications of our findings go beyond bank holding companies and the financial industry, and bear relevance to recent SEC deliberations regarding short-term borrowing disclosure regulation. JEL Classification: G14; G21; G28; M40


: The growing number of Electric Vehicles (EVs) will have remarkable impacts on the power grid as it leads to the increase in total energy consumption. This increases the overall burden on the grid which would require new power plants. However, it is possible to minimize the impact by proper scheduling for charging and discharging of electric vehicles. In this paper, three optimal schemes have been compared i.e. global optimal scheduling scheme and local optimal scheduling scheme and equal allocation scheme for EV charging and discharging. The first objective is to flatten the load profile. The EVs can be charged during off peak hours when the demand is less and can be discharged during peak hours when the demand is high. It will result in the constant power demand from the grid. The second objective is to minimize the total charging cost through scheduled charging and discharging.


Significance During pathogenic invasion, neutralizing antibodies (nAbs) are involved in regulating immune clearance and evoking the host-protective response. We previously reported a highly potent nAb 8C11 against HEV, an RNA virus with an icosahedral capsid and associated with abundant acute hepatitis. Structural analysis demonstrates that the binding of 8C11 to HEV VLPs would result in tremendous spatial clashing with the capsid. Cryo-EM analysis showed that 8C11 binding leads to complete disorder of the outer rim of the VLP at earlier stages (∼15 min) and causes the dissociation of HEV VLPs into homodimer species within 2 h. Similar 8C11-mediated dissociation was observed for the native HEV virion. Our results categorize a viral neutralization mechanism and suggest a strategy to generate 8C11-like antibodies. In adaptive immunity, organisms produce neutralizing antibodies (nAbs) to eliminate invading pathogens. Here, we explored whether viral neutralization could be attained through the physical disruption of a virus upon nAb binding. We report the neutralization mechanism of a potent nAb 8C11 against the hepatitis E virus (HEV), a nonenveloped positive-sense single-stranded RNA virus associated with abundant acute hepatitis. The 8C11 binding flanks the protrusion spike of the HEV viruslike particles (VLPs) and leads to tremendous physical collision between the antibody and the capsid, dissociating the VLPs into homodimer species within 2 h. Cryo-electron microscopy reconstruction of the dissociation intermediates at an earlier (15-min) stage revealed smeared protrusion spikes and a loss of icosahedral symmetry with the capsid core remaining unchanged. This structural disruption leads to the presence of only a few native HEV virions in the ultracentrifugation pellet and exposes the viral genome. Conceptually, we propose a strategy to raise collision-inducing nAbs against single spike moieties that feature in the context of the entire pathogen at positions where the neighboring space cannot afford to accommodate an antibody. This rationale may facilitate unique vaccine development and antimicrobial antibody design.


Each volume in the "Classics of Philosophy and Science" series is an annotated text prepared and edited with the aim of explaining key philosophical texts from the 17th century onwards. This translation of one of the most radical feminist tracts produced in 17th-century France has been provided with an introduction and notes. Poulain de la Barre adapted Descarte's philosophy to support claims that men's views of women were based on prejudice and custom, rather than reason or experience. He argued, like Marie de Gournay, that women are equal to men, and are capable of assuming all civil and ecclesiastical offices.


Considering the function of science history studies in science education,we have found through our analysis of some cases that for a long time the purpose of education determined the educational function of science history studies which can be called the history of science in education. With the development of the research in science history and the establishment of its scientific and pedagogical studies we understand the educational function of science history through science history studies. which can also be called education in science history. We hold that the change from science history in education to education in science history can avoid the whig interpretation of the science history and the distortion of the history of science.It can also help us truly understand the education function of science history structure.


Phagocytic capacity and the amount of PMN-granulocytes which take part in phagocytosis was investigated in patients with septicemia and polytrauma patients in comparison to PMN-granulocytes withdrawn from healthy volunteers by use of a standardized test-system in which autoclavated S.cerevisiae is the phagocytic agent. Influence of polyvalent immunoglobulin preparations together with patients' own serum incubation was compared with serum preincubation only in the test system mentioned above. It became evident that phagocytic capacity and the number of PMN-granulocytes which take part in phagocytosis in patients with septicemia are primary on a significant higher rate than those of other groups. PMN-granulocytes from polytraumated patients showed a significant higher rate on ingestion of S.cerevisiae pretreated with patients' own serum - especially after preopsonisation with immunoglobulins - than granulocytes from patients with septicemia or healthy volunteers.


The Bayes' factor, or likelihood ratio, plays an important role in the assessment of forensic evidence. Four methods of determining the Bayes' factor are developed. Backgraound data collected by forensic scientists often have a random effects structure where the random effects do not have a Normal distribution. The methods of Assessing these data compare results obtained where a group structure in the back ground data is and is not assumed, and where the within group variance is and is not assumed known. The distribution of the random effects is modelled using kernel density estimation. A simulation study shown that an improvement over the Normality assumption of the Bayes' factor estimates is obtained by using a kernel method when the random effects are not Normally distributed.


This study aims to investigate the factors affecting the saving behavior for retirement among workers in Kedah. This is because there is an issue where Malaysians workers having problem regarding their retirement savings that is not enough for retirement purposes. This study investigates the relationship between financial knowledge, self-suspension and future perspectives on saving behavior. Using a sample of 400 workers in the state of Kedah, the results showed that there is a direct significant relationship between the financial knowledge, self-suspension and perspective of the future with the saving attitude for retirement. The contribution of this study aimed to provide ideas and contributions to the government and the community in designing policy and future research presentations.


The following proposition is true (1) Let I be a set, and let J be a non empty set, and let f be a function from I into J∗, and let X be a many sorted set of J , and let p be an element of J∗, and let x be arbitrary. If x ∈ I and p = f(x), then (X · f)(x) = ∏ (X · p). Let I be a set, let A, B be many sorted sets of I, let C be a many sorted subset of A, and let F be a many sorted function from A into B. The functor F C yielding a many sorted function from C into B is defined as follows: (Def.1) For arbitrary i such that i ∈ I and for every function f from A(i) into B(i) such that f = F (i) holds (F C)(i) = f C(i). Let I be a set, let X be a many sorted set of I, and let i be arbitrary. Let us assume that i ∈ I. The functor coprod(i,X) yields a set and is defined as follows: (Def.2) For arbitrary x holds x ∈ coprod(i,X) iff there exists arbitrary a such that a ∈ X(i) and x = 〈a, i〉. Let I be a set and let X be a many sorted set of I. Then disjointX is a many sorted set of I and it can be characterized by the condition: (Def.3) For arbitrary i such that i ∈ I holds (disjointX)(i) = coprod(i,X).


One of the challenges in research is in understanding processes and systems that enable teachers to build their expertise and commitment to reform-based pedagogies. A qualitative study documented the influence that a set of support mechanisms, or connection levers, had in assisting upper primary teachers over the course of a year in developing confidence in teaching mathematics through inquiry.


Phosphate solubilizingbacteria are known to play a major role in the solubilization of unavailable forms of soil phosphorus and uptake its native and applied forms. A total of 17 different Pseudomonas flourescens isolates recovered from rhizosphere and J.curcas , planted in different localities, were evaluated for their phosphatase activity in in vitro and in vivo conditions. Isolates viz., P#10, P#l1 and P#02 revealed maximum phosphatase enzyme activity and influence the maximum growth and therefore can be used as bioinoculant in nursery and field trials for better production of J.curcas .


Purpose – The purpose of this paper is to examine the changes that have taken place in the family and relate these changes to where and how people eat.Design/methodology/approach – Female heads of household were surveyed via telephone interviews to identify the characteristics of how the modern family dines. The telephone interview was conducted by a commercial research organization and used random digit dialing methods to identify potential respondents. The personal telephone interview was conducted by trained interviewers provided by the research supplier. The respondents were screened to insure that the respondent was a head of household.Findings – Data revealed that families are reacting to time pressures in a way that changes the way they prepare foods while not affecting the end result. Overall, 75 percent of families eat as a family in the home five or more nights per week. In addition, 85 percent of those who eat together four nights a week or fewer, claim they would like to eat at home more often...


Acquiring market knowledge from distributors is critical for manufacturers to build long-term competitive advantage.However,previous studies neglect this question.This paper examines the relationship among manufacturer's attitudinal commitment,distributor's satisfaction and knowledge transfer.The results show that(1) Manufacturer's loyalty commitment has direct and positive impact on knowledge transfer,while calculative commitment has inversed U-shaped relationship with knowledge transfer.(2) Manufacturer's loyalty commitment can promote distributor's knowledge transfer through increasing its economic satisfaction.But manufacturer's calculative commitment will make negative impact on knowledge transfer through reducing both distributor's economic satisfaction and social satisfaction.This study indicates how manufacturers use attitudinal commitment to acquire valuable market knowledge through influencing distributors' satisfaction.The results provide some theoretical guidelines for manufacturers' acquiring knowledge from distributors.


In this paper, we present an analytical model for examining the growth impact of intergovernmental and intersectoral allocation of public expenditure. The model helps us quantify the role of fiscal decentralization in regional economic growth and identify whether central and local allocation of public spending among various sectors are growth-enhancing. Applying our analytical framework to a panel data set of 16 major states in India, we have found that, in many cases of our regressions, fiscal decentralization is positively, and even statistically significantly, associated with state economic growth. The state allocation of public spending in various sectors is broadly consistent with "growth-maximizing", whereas increases in the central allocation of its budget among development projects, nondevelopment projects, and social and community services by cutting the centeri¯s spending on all other functions can promote regional growth. Furthermore, the distortionary effect of the state tax in India is dominated by the productive effect of tax-financed public spending, whereas the reverse holds for the central tax.


When Britain leaves the EU in March 2019, will it become isolated and not influential, to paraphrase Sir John Major's words from his speech last week? In this blog, Monica Horten (LSE) investigates the Transition chapter of the EU Withdrawal Agreement and scrutinises how far Britain's influence could be written out from the very start.


Objective: The primary goals of our research were to explore pharmacists' perception of breastfeeding friendly pharmacy (BFPh) requirements and factors associated with their awareness about these requirements.
Methods: A cross-sectional study design was conducted using a self-administered survey. A convenience sample (n=381) of community pharmacists, was recruited through social media resources. Data were entered and analyzed using SPSS software version 35. The frequency or percentages were used for categorical variables while means and standard deviations were used for continuous variables. Also, linear regression analysis was used to evaluate factors affecting pharmacists' awareness about BFPh requirements.
Results: The majority of recruited pharmacists were female (n=329, 86.4%), aged between 23 to 30 years of age (78.7%, n=300). The most common steps to describe a pharmacy as a BFPh from the perspective of surveyed pharmacists were training all pharmacy staff to develop the necessary skills (n=239, 62.7%)) followed by informing all pregnant women about the benefits of breastfeeding (n=225, 59.1%)) and having a written policy on feeding infants and young children according to the recommendations of the WHO and in compliance with the international code (n=209, 54.9%)). Furthermore, pharmacists aging 40 years or less showed a significantly higher awareness about BFPh requirements compared to those aging above 40 years (beta=-0.013, p= 0.045). In addition, 37% (n=142) of pharmacists perceived that answering general questions or concerns on general medication intake while breastfeeding babies is their major role in breastfeeding support.
Conclusion: Breastfeeding support is a promising area for promoting professional pharmacy services. Training all pharmacy staff and informing all pregnant about the benefit of breastfeeding are the most common two steps to describe a pharmacy as BFPh. Additionally, the awareness of BFPh requirement was associated with pharmacists age. Future focus should be placed on implementing BFPh project in Jordanian pharmacies, where the steps of this project are modified in line with the capabilities of pharmacies in Jordan within governmental pharmaceutical control.


This work contains the formulation and implementation of the concept of transmission of electoral power wirelessly by using the principal of resonant coupling. In order to implement the idea of transmission of electrical power wirelessly, a power transmitter circuit on the sending side and a power receiver circuit on the receiving side has been designed. We used self-resonating Royer oscillator in the power transmitter circuit on the sending side. Both the power transmitter and power receiver circuits has been designed to operate at a similar frequency to accomplish the phenomenon of resonance on both sides. The common operating frequency is 1.2 MHz on both power transmitting and power receiving sides. Rectification and filtration circuits were also included in the power receiving circuitry to operate electrical appliances on the receiving side. Primarily, we charged the batteries of cell phone and emergency light of low wattage using this wirelessly transmitted received power. As our designed circuitry was of medium range, thus it worked efficiently within a range of 01 meter. The process of Wireless power transmission was not affected even when we placed a thick and opaque obstacle between the wireless power transmitter and wireless power receiver.


Driver-ZED (Zero Error Driving) is a computer program that teaches teenagers how to drive safely. Full-screen, full-motion, live-action video puts the novice driver in the driver's seat. The video is displayed on a simulated windshield frame, rearview, and left-side mirrors. It also includes a simulated dash with working speedometer and turn signals. The program contains four levels of interactivity in three driving environments: around town, in the country, and on the highway.


Preliminary studies have reported hypoglycaemic effects of leaf extracts of Ocimum gratissimum in type-1 diabetic animal models. However, the mechanism of its antihyperglycaemic activity remains unknown. To shed more light on this activity, we decided to investigate the efficacy of the extract in type-2 model diabetic rats, for which few reliable data are currently available. The results from this study show that aqueous extract of O. gratissimum leaf can significantly reduce postprandial hyperglycaemia in type-2 diabetic model rats, but without the risk of hypoglycemia. This property makes it potentially useful in type-2 diabetes human subjects with insulin resistance who are prone to high postprandial glucose surge.


Our identity as a human being is determined by the documents, not by appearance or physicality. The most important thing to prove the identity of humans is to show a government-issued document. Generally, from birth to death humans are recognized by documents because they are born with a birth certificate and they die with a death certificate. The main problem with these documents is that, they can be falsified or manipulated by others. Moreover in this digital era, they are stored in a centralized manner, which is prone to a cyber threat. This study aims to develop a blockchain environment to create, verify, and securely share documents in a decentralized manner. With the help of bigchainDB, interplanetary file system (IPFS), and asymmetric encryption, this research work will prototype the proposed solution called blockchain-based digital locker, which is similar to the DigiLocker released by the Department of Electronics and Information Technology (DeitY), Govt. of India. BigchainDB will help in treating each document as an asset by making it immutable with the help of IPFS and asymmetric encryption, where documents can not only be shared but also verified.


The GTD diffraction analysis of dual-shaped reflectors1,2 that are synthesized for high gain and low spillover past the subreflector can lead to erroneous results. The errors are particularly significant for the fields computed in the vicinity of the edge of the main reflector. Thus the computation of spillover energy past the main reflector and the noise figure of the high-gain system can be in error.


We propose a novel power control algorithm for the minimization of the peak load in the widely used load coupled network model, which is an abstract model able to capture the behavior of current and possibly future wireless networks. We first prove that the solution to the optimization problem we pose here requires all base stations with the same load. This necessary condition for optimality gives rise to a solver based on a bisection algorithm that requires an oracle able to answer whether a probed load is greater than the optimal value. By exploiting known properties of concave mappings, we devise an iterative oracle that, with a very mild assumption, provably gives the correct answer with a finite number of iterations. Simulations in an ultra-dense network show that the proposed algorithm can decrease the peak load by around 40% when compared to the peak load induced by the common approach of fixing the power of every base station to the maximum value.


Objective: to study, using immunohistochemical methods, the content of the vascular endothelial growth factor and transforming growth factor (TGF-β) in tissues adjacent to bone fragments after fracture in humans, as well as in autofibrin obtained in vitro. Methods: biopsy samples (interfragmental fibrin-blood clot, periosteum, muscular and fatty tissue), 9 of the victims recovered from the near fracture zone with fractures of limb bones during their open comparison were studied. In addition, fibrin-blood clots from the venous blood of the same patients obtained during the operation by the method of J. Choukroun were analyzed. Results: 1–2 days after the fracture, vascular endothelial growth factor concentrates in fibrin, forming a fibrin-blood clot in the near-fracture zone. On the 5 th –12 th day, the intensity of the reaction to vascular endothelial growth factor in fibrin decreases, or it disappears, and expression of the factor manifests itself in the cells of the regenerate — osteocytes, osteoblasts, fibroblasts, endotheliocytes. 10–12 days after injury, a positive reaction to vascular endothelial growth factor is defined in endotheliocytes and osteoblasts. The reaction to TGF-β in fibrin-blood clot and regenerate tissues was observed exclusively in cells. In autologous fibrin clots, vascular endothelial growth factor expression was observed in fibrin, and TGF was observed in the blood cells that remained in it. However, the intensity of the response to vascular endothelial growth factor in fibrin formed in vitro was uneven. Conclusions: vascular endothelial growth factorconcentration on the 1–2 day after fracture in the fibrin-blood clot in the near fracture zone is a strong signal for the restoration of blood supply in the area of injury. Expression of TGF-β at all times was found only in cells. The uneven distribution of vascular endothelial growth factor in fibrin formed in vitro should be considered when it is used to optimize bone repair.


Abstract To understand the nature of emerging future production and the influence of e-Work on enterprises, design principles and collaborative control theory have been and are being developed, and are described in this article. The "four wheels" of e-Work, their fifteen e-dimensions and their role in e-Production are discussed and illustrated. Network models and their emerging redesign counterparts are explained with implications to the future of production.


ABSTRACT The paper presents genealogy-oriented analysis of how the Nordic model gained its dominant characterization as modern, advanced and superior to other European welfare models while Southern European countries came to be labelled laggards in the welfare domain. To illuminate the relational nature of these, and all, comparisons, the analysis accentuates how researchers, politicians, and civil servants alike designate Nordic and Southern European states, their societies, and their welfare models. The empirical analysis focuses on scholarly writings about welfare-state comparisons (1986–2017) and on European Union documents addressing cohesion policies (1986–2021). Analysis of the vocabulary and labelling illuminates how the Scandocentric and the South-related bias have been produced and reproduced.The analysis indicates that labels, once established, tend to get replicated without question and grow unquestionable in science and policy-making both. While reducing complexity and increasing predictability, this process simultaneously constrains alternative ways to interpret changing situations and alternative contexts.-


Objective:To investigate the effectiveness of early and late nursing interventions for the patients with severe burn during the functional recovery.Methods:432 subjects were equally assigned to treatment group and control group.Early psychological support was given to the patients in treatment group,and simultaneously following nursing interventions were done:functional position,effective management to the wound,early functional exercises,skin care,pressure treatment,water bath,exercise training,etc.The patients in control group received routine nursing care.The rehabilitation results were analyzed through the revisit of patients to doctors,follow-up,telephone interviews and questionnaire half a year later.Results:The activities of daily living and range of joint motion were significantly improved,and severity of scar hypertrophy and pain alleviated in treatment group as compared with control group after treatment for 4-8 weeks (P0.01).Conclusion:Early,systematic and all-around nursing interventions to patients with severe burn could speed up rehabilitation process,reduce the occurrence and the severity of the sequela of severe burn effectively,and improve the quality of life of the patients.


One of the roles of the industrial sector in economic development is to improve the quality of life by expanding employment that will improve the welfare of the community. Industrialization, in any process always brings change. After the existence of industry, the main profession of the people of Wringinom Sub-district was not farmers but shifted to other sectors such as industry, services, trade. A shift in the profession has also caused a shift in socioeconomic values. The purpose of this research is to find out the socio-economic changes in the Wringinom District after the establishment of the factory. This study uses descriptive qualitative, namely research that produces descriptive data in the form of written or oral words from people and actors observed in the field.