Differences in the retention times of deuterium labeled compounds and unlabeled compounds were often observed during gas chromatography (GC)1)-6). Using a high-resolution capillary column, the difference was sufficient to induce complete fractionation between protioand deutero-forms; valproic acid and its 2H6 form7), ethylene dibromide and its 2H4 form8), and pipecolic acid and its 2H11 form9). We also reported isotopic fractionation of iproniazid and its metabolite, isopropylhydrazine from these 2H6 forms, and applied it to isotope dilution analysis of these compounds in plasma and urine10). Isotopic separation of aminopyrine and its 2H6 or 2H9 analogues was used to evaluate hepatic function". Furthermore, we have examined fractionation of isopropylantipyrine and various deuterated analogues. The isotopic separations were proportional to the number of labeled deuterium atoms and inversely proportional to the temperature of the column oven12). In this study, an isotopic fractionation technique was applied to the narcotic analgesic fentanyl (FT). We examined the effect of the deuterium labeling position and the number of labeled deuterium atoms in FT molecules on separation by capillary GC. Further, we estimated these effects thermodynamically, and considered the alternation of enthalpy and free energy between FT and deuterated FT.


Information is often presented in graphical form. Unfortunately, current assistive technologies such as screen readers are not well-equipped to handle these representations. To provide accessibility to graphs published in ``The Daily" (Statistics Canada's main dissemination venue), we have developed iGraph-Lite, a system that provides short verbal descriptions of the information depicted in graphs and a way to also interact with this information.


Road accidents are one of the major causes of human deaths. Most of the deaths in accidents are due to damage to the head of the motorcycle riders. Among the different types of road accidents, motorcycle accidents are common and cause severe injuries. To reduce the involved risk for the motorcycle riders, it is exceptionally fascinating to utilize helmet. The helmet is the motorcyclist's main protection. Most countries require the use of helmets by motorcyclists, but many people fail to obey the law for various reasons. We present the development of a system using deep convolutional neural networks (CNNs) for finding motorcyclists who are violating helmet laws. The system comprises motorcycle detection, helmet vs. no-helmet classification and counting process. Faster R-CNN with ResNet 50 network model is implementing for motorcycle detector process. CNN classification model proposes for classify the helmet vs. no-helmet. Finally making alarm sound to alert the officer to preventing motorcycle accident. We evaluate the system in terms of accuracy and speed and identify the number plate of the vehicle.


The effects of the environment on adhesive bonded single lap joints formed using XMC-3 and SMC-R50 composites were investigated. Tests were performed at temperatures of 23C and 93C with test coupons immersed in air, water, and 5% NaCl water mixture. The weight changes of both bonded joints (XMC-3 to SMC-R50 and SMC-R50 to SMC-R50) and unbonded materials were measured. Data were also ob tained showing the effects of moisture, temperature, and applied load on changes in weight, on creep deformation, lap shear strength, and separation modes of the joints.


The stability and reliability of multicore systems have been gotten more attentions with the widely used in all kinds of fields.After analyzing the current reliability model for chips,a reliability evaluating model considering the temperature and workloads for the multiprocessor is proposed.Based on construction characteristic of the multiprocessor,the model hierarchically constructs the evaluating index from instruction level to the task level that enables to quantitatively evaluate the reliability of the multiprocessor.To check the effectiveness of this model,a stability-oriented task scheduling algorithm is designed to enhance the stability of multicore system.It calculates the evaluating index for each scheduling scheme and chooses the scheduling scheme with highest evaluating index to obtain the low error rate caused by multicore.According to the results of simulation experiment,we can see that this model and method are effective that have the potential to reduce 45% of the error in multicore system.


We report fabrication of homostructural ZnO p–n junctions that contain arsenic (As)-doped ZnO (ZnO:As) and intrinsic n-type ZnO layers. We also describe the metallization process for forming ohmic contacts to p-type ZnO. ZnO films were synthesized on n-type SiC substrates by hybrid beam deposition. Ni/Au metal contacts show linear I–V characteristics indicative of ohmic behavior, while other metal contacts (e.g., In/Au and Ti/Au) show nonlinear characteristics with rectification that reveal the presence of Schottky barriers. The characteristics for p–n junctions composed of ZnO layers are confirmed by I–V measurements.


We study the two-user discrete memoryless compound multiple access channel (MAC) with common message and two specially correlated channel states each known non-causally by one of the encoders. Two channel states are correlated in the sense of Slepian-Wolf (SW) in which two correlated states are modeled by three independent states: a common state and two private states. By using superposition coding, binning scheme and jointly decoding, we propose several achievable rates for various cases of the two-user compound MAC with non-causal Slepian-Wolf channel states available at encoders and common message or conferencing encoders. Also, we show that the obtained achievable rate regions are optimal when perfect states are known at both decoders as well.


The driving speed and in particular the excessive driving speed of drivers, is considered as one of the factors contributing to traffic accidents over the last few years. High driving speeds are also considered to be an undesired burden for the environment. The governments traffic and transport policy aims therefore to control speed. In many countries much research has been done on methods and strategies which influence the speed behaviour of drivers. This report shows an overview of the current theoretical and practical insights of these methods and strategies.


Background: Hypertensive disorders complicating pregnancy are common and form one of the deadly triad, along with hemorrhage and infection that contribute greatly to maternal morbidity and mortality. Objective: To evaluate the role of middle cerebral artery and umbilical artery pulsatility index (PI) ratio in predicting neonatal outcome in pregnancies induced hypertension. Patients and methods: This study which included 100 women with severe preeclampsia admitted to Alsayed Galal University Hospital during the period between November 2018 and July 2019. Were evaluated the accuracy of middle cerebral/umbilical artery pulsatility index ratio in predicting admission to neonatal intensive care unit (NICU), acidemia and low Apgar score at 5 minutes after birth in neonates of severe preeclamptic pregnant women. Results: The best cut off value of middle cerebral artery (MCA) / umbilical artery (UA) PI ratio for prediction of NICU admission was sensitivity 62.5%, specificity 71.43%, positive predictive value (PPV) 29.41%, negative predictive value (NPV) 90.91% and the accuracy 70%. The cut off value of MCA/UA PI ratio for prediction of low Apgar score at 5 min was 50% sensitivity and 88.10% specificity. Estimated positive predictive value =44.44 and negative predictive value =90.24, and the cut off value of MCA/UA PI ratio for prediction of low UA PH were 43.75% sensitivity, 69.05% specificity, estimated positive predictive value =21.21, and negative predictive value =86.57. Conclusion: Doppler data combining both umbilical and cerebral velocimetry provides information on consequences of the placental abnormality; Hence, Doppler can be a useful tool in the management of patients with preeclampsia and can help in deciding the time of delivery so that the fetus can be saved.


Abstract:  Beta‐amyloid (Aβ) is a main component of senile plaques in Alzheimer's disease (AD) that induces neuronal cell death. Since reactive oxygen species (ROS) have been implicated in Aβ‐induced neurotoxicity, considerable attention has recently been focused on identifying naturally occurring antioxidative phenolic phytochemicals that are able to decrease ROS levels. Piceatannol (trans‐3,4,3′,5′‐tetrahydroxystilbene), which has a structure homologous to resveratrol, is an anti‐inflammatory and antiproliferative stilbene compound derived from plants. This article investigated the possible protective effects of piceatannol on Aβ‐induced PC12 neuronal cell death, and found that piceatannol exerted much stronger protective effects than did resveratrol. Piceatannol treatment attenuated the intracellular accumulation of ROS induced by treatment of PC12 cells with Aβ, inhibited Aβ‐induced apoptotic features including internucleosomal DNA fragmentation, nucleus condensation, cleavage of poly(ADP‐ribose) polymerase (PARP), and activation of caspase‐3. These results suggest that piceatannol blocks Aβ‐induced accumulation of ROS, thereby protecting PC12 cells from oxidative stress.


Established text characteristics help generate a random ergodic ensemble of characters constituting a random text image. The image is scaled in accordance with different optical parameters such as lens position, focal length, and change infocallength. The testimage is printed or displayed so that a Fourier Transform of the image can be taken and recorded. The recorded image is printed and constitutes an inverse filter. The inverse filter is positioned in an inverse Fourier Transform. An actual image (blurred text) undergoes a Fourier Transform and is then filtered by the inverse filter positioned at the inverse Fourier plane. The resulting filtered image then undergoes an inverse Fourier Transform so as to restore or at least greatly enhance the blurred image.


This paper examines real and financial linkages between Saudi Arabia and other GCC countries. Growth spillovers from Saudi Arabia to Bahrain are found to be sizeable and statistically significant, but those to other GCC countries are not found to be significant. Equity market movements in Saudi Arabia are found to have significant implications for other GCC countries, while there is no evidence of co-movements in bonds markets. These findings suggest some degree of interdependence among GCC countries.


The content overflow characterizing the information environment on social network sites (SNS) demands that news publishers compete for audience attention. As part of this competition, several tactics have been adopted by news editors (Molyneux & Coddington, 2020). Prominent among them is the clickbait headline (Bazaco, 2019; Beleslin et al., 2017; Mukherjee et al., 2019; Orosa, 2017). According to the Oxford English Dictionary, clickbait headlines are "(On the Internet) content whose main purpose is to attract attention and encourage visitors to click on a link to a particular web page," ("Clickbait" in Oxford English Dictionary, n.d), usually by using catchy, exaggerated, exciting, and sensational headlines, in order to maintain and exploit users' curiosity gap (Thiel, 2018).


Developmental defects in both deciduous and permanent dentitions occur as a result of disturbances in formation of hard tissue matrices and in their mineralization. The simultaneous development period of first permanent molars and the second deciduous molars is suggestive of a shared etiological factor in the origin of hypomineralization defects. Children with hypomineralized second deciduous molars are more susceptible to develop molar incisor hypomineralization. Therefore, the purpose of this case report is to document the association of deciduous molar hypomineralization with molar incisor hypomineralization in a 8-year old male child. This report further highlights the rise in demand for more attention at the age of 6-8 yrs, the period of the eruption of first permanent molars and permanent incisors. -------------------------------------------------------------------------------------------------------------------------------------Date of Submission: 10-01-2020 Date of Acceptance: 27-01-2020 -------------------------------------------------------------------------------------------------------------------------------------


The Mw7.6 Padang earthquake in 2009 attacked the northwest of Sumatra, Indonesia, and triggered many landslides, which killed at least 130 people at one village. We made satellite image interpretations, field investigations, and laboratory tests to identify the geomorphological and geological features of these landslides. As a result, we found that the number of landslides was 159, materials that slid were pumice fall deposits, and their sliding surface was made within the base of the pumice layer where pumice grains were mixed with underlying lahar and heavily weathered. These landslides had the following characteristics: 1) they occurred in the areas with pumice beds with >3 m thickness, which was controlled by the distance from their source; 2) the pumice fall deposits had a slope-parallel layering, which had been cut at the foots of slopes; and 3) the mixed layer at the base of the pumice beds was heavily weathered to be clayey materials with abundant halloysite. We made an isopach map of the pumice fall deposits, which is so-called Qhpt and believed to be from Maninjau Caldera. The isopach contours, however, showed that Qhpt is from Tandikat Volcano, and that landslides occurred in clusters in the areas with pumice beds thicker than 3.5 m. Qhpt beds had slope-parallel bedding, but they were undercut by subsequent river incision. Interpretations of stereoscopic satellite images and field surveys showed that there are four terraces along the Magung River, and Qhpt covers widely distributed higher terraces (Lh) of lahar younger than 80 ka and middle terraces (Lm) but are cut by lower terraces (Ll1 and Ll2) as well as small nearby tributary gullies. This undercutting likely reduced the support of Qhpt beds from downslope. The mixed layers, in which sliding surfaces were formed, were heavily weathered and very weak; weaker than the main Qhpt above and the lahar below. XRD analyses showed that pumice grains of the main part of Qhpt scarcely had halloysite but pumice grains and weathered lahar in the mixed layers were rich in halloysite. The formation of halloysite could be attributed to the interaction between the materials of the mixed layers and the water coming through Qhpt beds; water, which gets Si and other chemical components from the volcanic glass of pumice, may become stagnant in the mixed layers because they are much less permeable than the Qhpt beds above. This would be a preferable condition of halloysite formation. Infinite slope stability analysis using geotechnical parameters, pumice bed thickness, and slope angles, which we obtained, suggested that landslides with sliding surfaces within the mixed layers could be triggered by the shaking of the 2009 Padang earthquake. The natural water contents of the materials of the mixed layers exceeded their liquid limits, which suggests that they would behave like a liquid after remolding. The geological history, which is volcanic eruption, weathering, and undercutting by river incision as stated above, is typical in tropical volcanic areas. That means we can make a hazard map of such a catastrophic landslide induced by earthquakes on the basis of geological development.


This paper intends to emphatize some aspects of teaching life, dealing with troubles based on Cultural Studies and with analysis from Foucault's inspiration. We aim to point out the different speeches that form the teacher's identity, even though the hardness faced by the new teachers in their arrival at the schools. We consider the school possessing a specific culture regarding to the production of knowledge and in the formation of the teachers that participate in its institutional structure. The teachers are constituted by a title and are bind to it. There is a charge of meanings that are proper of this modern world and that cannot be thought in a different way. It becomes clear that this production is not exclusively from a school's culture, it is done in and outside from the walls of the school. These are the discussions focused through the entire text, pointing out the necessity of thinking how this teacher it is being narrated, subjectived and identified and how it is important to know such narratives. Knowing is an act of governing.


Objective To detect the characteristics of changes of neurotransmitter in different regions of the schizophrenics' brain with encephalofluctuograph(EFG),and explore its clinical significance in the treatment of schizophrenia.Methods Thirty-nine patients with schizophrenia(case group) and forty-nine normal controls(control group) were detected for encephaloelectrical power signals in different regions of the schizophrenics' brain with EFG,and the characteristics of changes of neurotransmitter in different parts of the schizophrenics' brain were analyzed.Results The powers of excitatory neurotransmitter 3,5-HT,Ach,excitatory neurotransmitter 6,NE,DA,inhibitory neurotransmitter 13 in the left and right frontal region,around the central,left and right anterior temporal of case group were significantly higher than those of control group(P 0.05).The relative power of Glu in the left and right occipital region of case group was significantly higher than that of control group,and the relative power of GABA in right occipital region of case group was significantly higher than that of control group(P 0.05).Conclusion It involves different regions of brain such as temporal region,frontal lobe,central region which may cause the dysfunction of brain in patients with schizophrenia.


Objective of this paper is synthesis of metal-oxide supported on conducting substrate by electrochemical deposition. According to this study analysis of metal oxide thin film were done for physico-chemical properties like pH, current density, specific capacitance Vs voltage, surface area, cycle stability and coulombic efficiency. In order to get efficient metal-oxide thin film for various metal-oxide. Finally, higher energy density materials with better stability in an actual operating condition can be obtained by chemical route.


Image segmentation as the processing of partitioning a digital image into multiple segments has wide applications, such as image retrieval, medical inspection, and computer forensics. Clustering methods as one solution are applied on a single or multiple feature spaces of an image, such as color, intensity, or texture, in order to group similar pixels that share certain visual characteristics. Given a particular color image, not all features from a color space, such as RGB, HSV, or Lab, are equally effective in describing the visual characteristics of segments. In this paper, we propose a projective clustering algorithm HCPC (Hill-Climbing based Projective Clustering) which utilizes EPCH (an efficient projective clustering technique by histogram construction) as the main framework and hill-climbing algorithm for dense region detection, for color image segmentation, thereby finding interesting clusters (segments) within subspaces of a given feature space. A new feature space, named HSVrVgVb, is also explored which is derived from HSV (Hue, Saturation, and Value) color space. The experimental results show that compared with hill-climbing algorithm (for efficient color-based image segmentation), our proposed algorithm is more scalable when the dimensionality of feature space is high, and also generates comparable segmentation results.


Known radiation emission mechanisms in plasmas include bremmstrahlung (or free-free emission), gyro- and synchrotron radiation, cyclotron maser, and plasma emission. For unmagnetized plasmas, only bremmstrahlung and plasma emissions are viable. Of these, bremmstrahlung becomes inoperative in the absence of collisions, and the plasma emission requires the presence of electron beam, followed by various scattering and conversion processes. The present Letter proposes a new type of radiation emission process for plasmas in a state of thermodynamic quasi-equilibrium between particles and enhanced Langmuir turbulence. The radiation emission mechanism proposed in the present Letter is not predicted by the linear theory of thermal plasmas, but it relies on nonlinear wave-particle resonance processes. The electromagnetic particle-in-cell numerical simulation supports the new mechanism.


Odontogenic ghost cell carcinoma (OGCC) is a rare and aggressive tumor wherein optimal treatment remains uncertain. We report the first pediatric metastatic OGCC case treated with multimodal therapy: surgery, adjuvant chemoradiation, and adjuvant immunotherapy. Adjuvant therapy was utilized due to locally advanced disease with pathologic features indicative of high recurrence risk. This multimodal approach was modeled after management of primary head and neck cancer, where adjuvant chemoradiation and immunotherapy are associated with improved outcomes. Our patient is alive and disease free at 14 months indicating a potentially positive role for multimodal therapy in the management of OGCC.


Impact that machining has on surface integrity of a finished product is a major concern for engineers and scientists. Main issues are the prediction of the chip formation and the changes in the microstructure, mechanical properties and corrosion behaviour of machined materials. In this work, we are studying the effect of machining in orthogonal cutting configuration (turning) on the microstructure (phase transformation, recristallisation), the mechanical behaviour and the corrosion resistance in salt fog atmosphere of a martensitic stainless steel. Experimental approaches and numerical methods by Finite Elements are coupled. Mots clefs: Tournage, acier inoxydable, surface usinee, changement de phase, modelisation


The wavevector selection rules (WVSR) occurring in the reduction of Kronecker products of space group unirreps are classified, for convenience, into three types. For WVSR of type I, Dirl (1979) has shown that special solutions of the multiplicity problem always exist. For WVSR of type II, Dirl has given a simple criterion for the existence for special solutions of the multiplicity problem and the authors show that, for all 230 (single and double) space groups, the Miller and Love matrix unirreps satisfy this criterion. WVSR of type III will be considered in a subsequent paper.


The invention provides an input device and an electronic device. The input device includes a storage section, a display section, a touch sensor, a control section, and a display switch section. The control section switches the display state of a to-be-deleted symbol string on the display section to any one of a second half hiding state, a first half hiding state, and a full display state every time the display switch section is pressed during touch operation on the display section by a user. The second half hiding state is to hide a second half symbol string, out of the to-be-deleted symbol string, displayed behind a deletion reference position. The first half hiding state is to hide a first half symbol string, out of the to-be-deleted symbol string, displayed before the deletion reference position. The full display state is to display the to-be-deleted symbol string in full.


The present invention relates to a manufacturing apparatus for manufacturing a first layer comprising at least a layer structure on a patterned substrate. Providing the layer structure (6) of the first layer having an unpatterned on the substrate. Protective material application unit (8) in the protective material is applied to at least a portion of the ablation layer unit provided moiety onto at least a protective layer structure is provided (6) (12) through the protective material ablation unpatterned of the first layer so as to generate a first patterned layer and the protective material removal unit (15) removing the protective material (9). This allows the manufacture of an OLED, for example, a layer structure without using expensive and technically complicated photolithography process. In addition, the ablation debris may be removed with the removal of the protective material, thereby reducing the likelihood of deleterious effects such as OLED harmful short circuit caused by harmful residues.


This paper establishes the link between human activity and climate change, e.g., more frequent and devastating typhoons, tornadoes, bushfires, droughts, floods and snowstorms and melting of the norther polar ice cap and recent occurrences of super typhoons and tornadoes. Qualitative mathematics and modeling(QMAM) explains this link and its remarkable verification based on the grand unified theory(GUT).


AbstractIn Part I of this paper I have covered in some detail the background of the use of barometers as height measuring instruments, and also the precautions which must be observed in order to overcome the effects of weather and atmospheric phenomena. It now remains to consider the various field and office procedures which have been developed over the years with a view to improving accuracy and speed.


Provisions of the budget resolution of the U.S. House of Representatives — now up for debate in the Senate — would cut funding for programs in family planning, nutritional assistance, and prenatal care, threatening the health of low-income women and children.


Variational approaches, such as variational Monte Carlo (VMC) or the variational quantum eigensolver (VQE), are powerful techniques to tackle the ground-state many-electron problem. Often, the family of variational states is not invariant under the reparametrization of the Hamiltonian by single-particle basis transformations. As a consequence, the representability of the ground-state wave function by the variational ansatz strongly dependents on the choice of the single-particle basis. In this manuscript we study the joint optimization of the single-particle basis, together with the variational state in the VMC (with neural quantum states) and VQE (with hardware-efficient circuits) approaches. We show that the joint optimization of the single-particle basis with the variational state parameters yields significant improvements in the expressive power and optimization landscape in a variety of chemistry and condensed matter systems. We also realize the first active-space calculation using neural quantum states, where the single-particle basis transformations are applied to all of the orbitals in the basis set.


The aim of this study was to investigate the patterns and predictors of drug use among undergraduates in Akwa Ibom state. A cross-sectional study of 600 randomly selected students was conducted, using standard measures of drug use and a section to measure drug use and demographic variables. Respondents' mean age was 21.05 years (SD = 4.24) while age at drug use debut was 16.15 (SD = 2.01). Results showed that, overall, mean score on DUDIT was 27.55 (7.46). A comparison of respondents from the 3 universities showed no significant difference in drug use: 27.16, 28.55 and 26.95 for UniUyo, AKSU and RU respectively. Results also showed that while 22.66% of respondents never used drugs other than alcohol, about 77% had used drugs other than alcohol ranging from between twice a month to about twice a week. Results also indicated that about 45% of respondents were poly drug users of varying degrees. The most significant correlates of drug use were male sex (r = -.43; p<.01), earlier age at drug use debut (r = -. 42; p<.01), Off-campus residential status (r = .37; p<.01); and current age (r = -.29: p<.01). It is recommended that intervention aimed at reducing high risk drug use and provision of services


In 2003, interests in the Institute of Electronics and Electrical Engineering (IEEE) 802.11 Working Group (WG) led to the formation of Task Group (TG) "S". 802.11s develops a Wireless Mesh Network (WMN) amendment. Unlike existing Mesh products, 802.11s forms a transparent 802 broadcast domain that supports any higher layer protocols. Therefore, 802.11s provides frame forwarding and path selection at layer-2. 802.11i describes a security concept for stations that associate with an Access Point (AP). However, in a Mesh Basic Service Set (BSS) devices need to mutually authenticate to provide integrity of the network. Thus, 802.11s adds additional elements to the concepts of 802.11L While traditional Wireless Local Area Networks (WLANs) are AP centred an 802.11 Mesh is fully distributed. Hence, 802.11s considers extensions to the Medium Access Control (MAC) too. The authors have contributed to the standardization of 802.11s since 2003. As constant participants we give insight to draft 1.02 of TG "s" and provide an outlook to future evolution of 802.11's first Mesh standard.


The monosyllable adverbs in ancient Chinese mainly derive from the notional words whose meaning is lost. There are two ways in which compound adverbs include combining and overlapping. The evolution from the meaningful to the meaningless of notional words contains direct way, indirect way and borrowing way. In the course of evolution of monosyllable, the adverbs which indicate time, range, state, degree and speculation have the most powerful ability to form word and last longer.


The present invention relates to a method for conveying member or members from the group of stations to one or more stations of the delivery device, wherein said conveying means comprises a conveying track and the support member of the vehicle motion on the conveying track, and wherein disposed in the region of the station in the conveying track positioning means, the positioning means thus cooperate with the support member to the car positioning mechanism, thereby directly through the support member to the vehicle entry into the station motion along all three spatial directions (X, Y, Z) occupy a desired position of the support member in the station in the vehicle, characterized in that the support member into the movement of the entire vehicle entry station during the positioning of the desired position only in contact therewith determining means on the conveying track in each of the positioning mechanism of the supporting member of the vehicle.


Forty-two G. herbaceum cultivars available in Iran National Gene Bank were analysed karyologically showing 2n=26 chromosome number. The cultivars varied with regard to number of SAT-chromosomes and chromosomes carrying secondary constrictions. Karyotypes were of symmetrical type having small chromosomes. Factorial analysis showed significant difference for both the cultivars as well as chromosomes.Cluster analysis using UPGMA, single linkage and complete linkage methods grouped the cultivars in six distinct clusters. Principal coordinate analysis supports the clustering results and principal component analysis showed that chromosomes 4 to 10 and long arms of the chromosomes 2, 8, 10 and 13 and short arms of the chromosomes 3, 7 and 8 are the most variable chromosomes/chromosome arms among the cultivars studied.Present work indicates genomic differences among diploid G. herbaceum cultivars of Iran which can be used in hybridization programs. Crossing of the cultivars placed in distant clusters are suggested.


The multicenter prospective CREST‐2 Registry (C2R) provides recent experience in performing carotid artery stenting (CAS) for interventionists to ensure safe performance of CAS.


Decay properties of an isotope {sup 266}Bh and its daughter nucleus {sup 262}Db produced by the {sup 248}Cm({sup 23}Na,5n) reaction were studied by using a gas-filled recoil separator coupled with a position-sensitive semiconductor detector. {sup 266}Bh was clearly identified from the correlation of the known nuclide, {sup 262}Db. The obtained decay properties of {sup 266}Bh and {sup 262}Db are consistent with those observed in the {sup 278}113 chain by RIKEN collaboration, which provided further confirmation of the discovery of {sup 278}113.


Pio XI (or Brtiggen) Glacier is probably the only glacier in the world currently at its Neoglacial maximum. Its recent fluctuations provide a striking example of non-climatic glacier behaviour. A rapid 3 km advance in the \920s was followed by retreat in the 1930s. Between 1945 and 1983 the glacier advanced 10 km at a mean rate of 263 m a, since when it has oscillated around a quasi-stable position. In 1992 the terminus was advancing over large accumulations of proglacial sediment and the western margin was advancing into mature forest composed of southern beech (Nothofagus spp.) and Pilgerodendron uviferum. The pro glacial delta has aggraded to sea level along two thirds of the front and the water depth is 22 m, pennitting on! y small-scale ea! ving. The advance has blocked a tributary valley, forming a 240 km ice-dammed lake into which large-scale, frequent calving is taking place. This pattern of behaviour cannot be explained with reference to climate alone. A simple descriptive model combining calving dynamics, sediment budget, fjord topography and climate explains the main features of recent behaviour. Many other Patagonian calving glaciers have also responded indirectly to climate this century. Since the established Late Glacial and Holocene chronology ofPatagonian glacier oscillations is largely based on records from sites at calving glaciers, its validity and its uncritical use in inter-hemispheric comparative studies is questionable.


Recent research on the early modern European family has largely been based on archival sources that are extant for relatively few localities during this same period. This research can be augmented by examining discussions of the family contained within academic writings on theology, jurisprudence, medicine, and philosophy during the early modern period. This article focuses on philosophical writings that arose in connection with sixteenth- and seventeenth-century academic instruction. These writings routinely discuss the proper relationship between husband and wife, between parents and children, and between masters and servants; also discussed are various categories of domestic possessions and how these possessions should be acquired and administered. Within these philosophical writings, one controversial issue pertaining to family life is sometimes raised: whether servants are more essential to the family than children. These writings uniformly equate the family with the nuclear family; in doing so, they provide collaboration for similar findings by social and demographic historians.


The active movement of the Russian Empire to the East for three centuries and its colossal success led to the need for some Russian thinkers and publicists to analyze this unique phenomenon as part of the general European colonial 'movement' to the East. The problem became more relevant than ever after the Sino-Japanese war (1894–1895), when the expansion of Russia to the East intensified, and all the world powers started to formulate their interests in China. Conflicts with and around China among these countries became widespread. Here the Russian press played a great role, accompanying and commenting on each step made by Russian diplomats and military. The discussions gradually highlighted two different problems. These were the ideas of 'yellow peril' and 'Russia's special mission in the East'.


In this paper, we describe development of an optical time transfer infrastructure with sub-nanosecond accuracy over the dense wavelength division multiplexed national research network in the Czech Republic.


To obtain pure superoxide disnutase(SOD) from fresh chick heart and explore its enzymatic properties,Mn superoxide disnutase(Mn-SOD) was isolated and purified by homogenization,normal butanol defatting,acetone fractional precipitation,DEAE-Sepharose chromatography and Superdex-200 gel filtration.The specific activity of the purified superoxide disnutase was 1 633 U/mg and its purification fold was 139.16.Its relative molecular weight and subunit relative molecular weight was about 103.7 KD and 23.6 KD,respectively.The superoxide disnutase was relatively stable under a temperatture of 50 ℃-70 ℃ and a Ph of 3-9,the optimum temperature being 40 ℃.Ca2+,dithiothreitol and urea could activate the enzyme,Ba2+ and Zn2+ showed some inhibition,and Cu2+ strongly inhibited its activity.EDTA-2Na activated the enzyme at low concentration and inhibited it at high concentration.


Department of Radiologic, Oncologic and Pathologic Sciences, La Sapienza University, Rome, Italy, Department of Surgical and Biomedical Sciences, Second Division of Radiology, University of Perugia, Perugia, Italy, Provincial Health Care Services, Institute of Pathology, Santa Maria Del Carmine Hospital, Rovereto, Italy, and Department of Diagnostic and Clinical Medicine and of Public Health, University of Modena and Reggio Emilia, Modena, Italy


Agricultural development in Nepal must be better organized as well as integrated with family planning in order to meet goals set forth in the government Development Plans. Previous plans especially the Fourth Plan fell short because of unrealistic production goals and poor coordination between different levels of government especially at the district level. To reorganize development efforts the king has formed a Development Council which he will head. The coming year will be designated the agricultural year. New goals will be to achieve balanced development including horticultural development in the hills cereals in the Terai and livestock in the mountains. The Fifth Development Plan will aim for equitable distribution maximum utilization of labor and regional coordination. The target growth in GDP will be 5% per year. Family planning cannot be considered merely a matter of birth control but must be integrated into social and economic development. Rapid population growth is an intensifier of other problems of development. As has been proposed in Sri Lanka and India farmers who do not maintain productivity should be deprived of land ownership.


This study aims to determine the improvement of the mechanical properties of ductile cast iron (FCD-50) against hardness, impact and macrostructure by heat treatment process. This study uses FCD-50 gray cast iron, with the first test being specimens without treatment and the second test as a comparison, namely variations in temperature heat treatment, namely 800 0 C, 850 0 C and 900 0 C with holding time for 30 minutes, and cooling using oil. The results of the hardness test showed that the FCD-50 nodular cast iron obtained different results, namely where the untreated FCD-50 cast iron was more likely to experience a decrease in hardness with an average hardness value of 18.5 HRC, while heat treatment 800 0 C is more likely to experience an increase in hardness with an average hardness value of 25.37 HRC, while heat treatment at 850 0 C is more likely to experience an increase in hardness with an average hardness value of 57.48 HRC, while heat treatment 900 0 C is more tend to experience an increase in hardness with an average hardness value of 68.42 HRC. The results of the impact test showed that FCD-50 nodular cast iron showed that without heat treatment, the average impact energy was 9,638 Joule/mm2. In the 8000C heat treatment process, the average amount of impact energy is 6.554 Joule/mm2. In the 850 0 C heat treatment process, the average amount of impact energy is 7.517 Joule/mm2. In the 900 0 C heat treatment process, the average impact energy is 3,277 Joules/mm2. The results showed that under the influence of the treatment process increased hardness, and gave changes to ferrite, pearlite and graphite, namely more pearlite structure and less graphite and ferrite structures than the As-Cast specimens.


The study was conducted at the Institute of Agricultural Extension and Rural Development, University of Agriculture, Faisalabad, Pakistan during the year 2014. For this study Hazara region of Khyber Pakhtumkhwa was selected. In mountainous rural areas of Pakistan, livelihoods are highly dependent on natural resources which in turn depend upon climatic conditions. Agriculture is a main source of rural livelihoods, but due to climate change the livelihoods of rural dwellers become more vulnerable due to the adverse effects of climate change on agriculture. Hazara region comprises six districts (Haripur, Abbotabd, Mansehra, Kohistan, Bttagram and Tor Ghur) and is full with natural resources. District Mansehra was purposively selected as the study area. Cross-sectional survey research design was used in this study. One hundred and twenty respondents were selected randomly from rural areas three tehsiles of district Mansehra. The results indicated that majority of respondents (48.3%) were illiterate. Both farming and non-farming was the main source of income for majority (45.0%) of the respondents. It was also found that all respondents were of the view that there exists a rise in temperature which is a major cause of global warming. Regarding the impacts of climate change on livelihoods of rural people it was found that "increase intensity of natural disaster", was at the top with highest mean value (M=4.42). Among different variables of rural livelihoods "increase in human mortality rate" was found at the lowest level with lowest mean value (M= 3.40). From the results it was concluded that climate change has adverse impacts on the livelihoods of rural communities in the region and different state departments (agri. extension and forestry) should launch awareness campaigns regarding adoption of different adaptation strategies of climate change so that small farmers can easily secure their livelihoods.


We report a case of cerebellar abscess secondary to chronic otitis by caused by Shewanella putrefaciens and localized in the cerebellar hemisphere, in a paediatric patient.


[Objective] The aim was to study the effect of self-made Guchang Cuchang San on pepsase and trypsin of piglets with spleen deficiency.[Method] Piglets model of spleen deficiency was formed by injecting piglets with reserpine as well as the alternative treatment of no-feeding and feeding,the activity of pepsase and the content of trypsin of piglets were determined before injecting piglets with reserpine,on the day of injecting reserpine,the second and the eighth day after giving medicine,respectively.[Result] After the test was finished,the activities of every enzymes of Guchang Cuchang San group had no significant difference with normal control group,while the activities of every enzymes of spleen deficiency control group and Smecta group had significant difference with normal control group.[Conclusion] Guchang Cuchang San can promote the pepsase activity and trypsin recovery of piglets of spleen deficiency caused by reserpine.


The main objective of this work was to study the rheological characteristics of a newly developed friction-promoting grease (FPG) in China that has been widely used for the lubrication and protection of multi-rope friction hoists. A stereo microscope was used to determine the microstructure of the grease. A series of rheological tests were performed on a cone-plate rheometer to investigate the thixotropic shear-thinning behavior under several constant temperature conditions and examine the changes in the apparent viscosity when the temperature is increased while the shear rate is kept constant. Experimental results indicated that within the temperature range of 20°C to 30°C, a lower temperature could lead to a stronger thixotropy of the FPG. Within the temperature range of 20°C to 160°C, a lower temperature could result in a greater yield stress and a more intense shear-thinning behavior of the FPG, which was in good agreement with Sisko's model. It should be noted that at 170°C and 180°C, the apparent viscosity showed a slightly ascending trend at low shear rates and a stable value was gradually approached as the shear rate increased. Under a constant shear rate, the apparent viscosity remained stable after decreasing and then finally increased with an increase in the temperature.


Through the decades, the pulp and paper industry greatly expanded production capacity to meet increasing demands. Correspondingly, the cost of corrosion damage soared. The most serious corrosion control challenges were researched and met by university and governmental researchers, and by task groups within the TAPPI Engineering Division's Corrosion and Materials Engineering Committee. Today, thanks to material and process advances, mills encounter less corrosion than in the past. This overview takes a historical look back, covering many decades, at how corrosion problems have been managed in the pulp and paper industry. Yet, corrosion keeps on going, and today mills appear less able to manage corrosion problems for which known solutions are available. This paper also addresses the significant yet underrated task of optimizing corrosion control management in the present and into the future. Discussion is provided on best practices needed to mitigate new and ongoing corrosion problems.


It is a hot topic for researchers to boost users retrieval efficiency and satisfactory degree according to a retrievers query results in the existing searchable encryption schemes in cloud computing. Considering that traditional work on searchable encryption rarely refers to the interaction between the user and the cloud, this paper proposes a method to improve the systems usability and users satisfactory degree in the fuzzy keyword search field. In this paper, based on [1] and [2], for the first time we solve the problem of full-scale fuzzy keyword set construction according to the input keyword, and construct the feedback scheme to produce pointer vector including fuzzy keyword, edit distance and keywords dynamic score, which is feasible in hybrid cloud model. Thus, different vectors form the character vector database within its data structure. It can go to the trapdoor construction procedure after access to the database with its edit distances to construct fuzzy keyword set, which makes the fullest use of the retrieval history and statistical misspelled keywords, precisely and quickly realizing the aim of ranked fuzzy keyword search over cloud encrypted data. Thorough rigorous security analyses realize privacy preservation, as well as improvement of the solution which can meet satisfaction needs of users. And experiments show that efficiency and precision are clearly achieved in the proposed solution, the retrieval time overhead is improved after many times as well.


L-kynureninase (KYNU), an enzyme in the tryptophan metabolism pathway, is habitually found as a differentially expressed gene (DEG) in psoriasis. Although many DEGs have known function in regards to psoriasis and inflammation, KYNU has been completely unexplored in both psoriasis and within general immunology. Here we show that psoriatic lesional skin has significantly increased KYNU mRNA, and is infiltrated by large numbers of KYNU + cells, as determined by qRT-PCR and immunohistochemistry, respectively. The identity of KYNU + cells was elucidated using both two- color immunofluorescence and qRT-PCR. Although KYNU is expressed in several cell lineages, myeloid subsets were found to express 100-fold more KYNU compared to all other cell types, sug- gesting a likely immunomodulatory role for this enzyme. To determine how KYNU may contribute to inflammation, primary human cutaneous cells were cultured with specific tryptophan metabolites, and modulation of gene expression was assessed. Interestingly, metabolites downstream of KYNU induced significant upregulation of several inflammatory genes (including IL-20, IL-8, CCL2, CXCL1, VCAM, ICAM, and E-selectin), with the metabolite directly produced by KYNU (3-hydroxyanthra-nilic acid) inducing the highest amount of inflammatory gene upregulation. Conversely, metabolites upstream of KYNU (such as the AhR-ligand, kynurenine) had minimal ability to induce and even suppressed expression of some inflammatory genes. Therefore, KYNU may be a pivotal switch in tryptophan metabolism and dictate an inflammatory outcome. By mining gene array data, we found many other human diseases, including atopic dermatitis and lupus, also contain elevated KYNU, suggesting a role of this enzyme not only in psoriasis, but also in general cutaneous inflammation. The purpose of the study was to identify clinical and laboratory predictors of skin disease outcome in patients with refractory dermatomyositis (DM) treated with rituximab. We analyzed data for 116 DM patients (68 with adult DM and 48 with juvenile DM) in the Rituximab in Myositis trial. Skin disease outcome was defined as the absolute change from baseline to 24 weeks in the Cutaneous Disease Activity visual analog scale (VAS) score where a negative change indicated improvement and a positive change indicated worsening. We analyzed the association of the following baseline variables with skin disease outcome: demographics, dermatomyositis subtype, clinical and labora- tory parameters, myositis autoantibodies (antisynthetase, anti–Mi-2, other autoantibodies, and no autoantibodies), and interferon (IFN)-regulated chemokines. Multivariable linear regression models were developed using stepwise variable selection methods. A multivariable model to predict skin disease outcome was built with good predictive ability (adjusted R 2 =0.33). The model included three factors at baseline: Cutaneous Disease Activity VAS score (b [regression coefficient] = -0.48, P < 0.01), Constitutional Disease Activity VAS score (b = 0.20, P 0.02), and anti–Mi-2 status (b = -5.71, P < 0.01). This indicates that participants with higher Cutaneous Disease Activity VAS scores at baseline were more likely to improve in their Cutaneous Disease Activity VAS scores from baseline to 24 weeks, participants with higher Constitutional Disease Activity VAS scores at baseline were more likely to worsen, and participants with positive anti–Mi-2 status at baseline were more likely to improve. This model could be clinically useful to optimize treatment selection in DM patients with recalcitrant skin disease. symptom (LE), LE, symptom discontinuation. infliximab users. Cutaneous malar photosensitivity, subacute cutaneous LE (SCLE), and discoid lupus-type lesions. a case of a 57-year-old infliximab infusions for rheumatoid arthritis (RA) who presented with an 8-month history of a progressively worsening facial Physical periorbital edema, with erythematous papules and plaques on the and Review of systems was otherwise negative. the coincided with a new-onset superficial and deep perivascular and interstitial mixed-cell infil- trates comprised predominately of lymphocytes and histiocytes, with occasional neutrophils and mucin, consistent with a connective tissue disease process. revealed ANA of 1:640 (homogenous pattern) and elevated dsDNA. The upon discontinuation of infliximab and initiation of chloroquine, and autoantibodies normalized. Thereafter, her RA was successfully managed by abatacept without lesion recurrence. While the pathogenesis of TAILS is not entirely understood, one proposed mechanism is that relative immunosuppression encourages increased infection rates and activation of polyclonal B lymphocytes, which stimulates autoantibody production. 1 This case may be a clinical illustration of this mechanism, as the patient developed a rash and autoantibodies consistent with cutaneous LE while on a TNF- α inhibitor and soon after infection, with resolution upon antimalarial therapy and discontinuation of infliximab. with various types of inflammatory skin disease are accompanied by increased angiogenesis as is the case for the flaky skin (Ttc7 fsn ) and chronic proliferative dermatitis (Sharpin cpdm Sharpin cpdm-Dem ) models. The C3H/HeJ inbred strain spontaneously develops alopecia areata (AA), a cell mediated autoimmune disorder which can be controllably expanded using full thickness skin grafts to young unaffected mice. This provides a reproducible and progressive model for AA in which the vascularization of the skin can be examined. Mice receiving skin grafts from AA or sham surgery were evaluated at 5, 10, 15, and 20 weeks after engraftment. Blood vessels were found to be slightly more numerous and dilated compared to controls by immunohistochemistry. This was more pronounced using antibodies directed against smooth muscle actin isoforms than CD31. Lymphatics are often overlooked as they are small slit-like dermal structures above the angle of the hair follicles. These lymphatics are often missed as they resemble artifactual separation of collagen bundles with some fixatives. Lymphatics are easily detected using LYVE1 by immunohistochemistry to label their endothelial cells. Using LYVE1 there were no changes in distribution or numbers of lymphatics although they were more prominent (dilated) in the mice with alopecia areata. Lyve1 transcripts were not significantly upregulated except at 10 weeks after skin grafting when clinical signs of AA first become apparent. Other genes involved with vascular growth and dilation were dysregulated. These findings emphasize aspects of AA not commonly considered in the evaluation of human and other species affected. present- (IMQ)over consecutive days psoriatic-dermatitis, responses of LCs were analyzed subsequently. The LCs in the epidermis after IMQ for 24h IMQ, increasedexpression ofIL-23was observed.Taken ourstudyshowedthat LCs promote the development of IMQ-induced psoriasis-like dermatitis by producing IL-23, and LCs a future strategy for the treatment of psoriasis. autoimmune autoantibodies genetic of SLE that interferon regulatory factor (IRF) 7 gene polymorphisms are associated with an increased risk of SLE but the precise role of IRF7 in SLE development is not fully IRF7 a member of the IRF family of transcription factors that induce transcription of IFN- α and the expression of interferon (IFN)-stimulated genes (ISGs). the role of IRF7 in the pathogenesis of SLE, a murine model of SLE induced by 2,6,10,14-tetramethylpen- (TMPD) IRF7 deficient and wild-type (WT) control intraperitoneally with TMPD and spleens, and 2 weeks or 10 months Proteinuria on dipstick analysis in both WT and IRF7 deficient mice and direct immunofluorescence of the glomerular IgG in both strains to the anti-dsDNA, ssDNA, RNP and Sm autoantibodies were by in the from IRF7 deficient mice were in the from WT Real-time PCR spleen from IRF7 deficient substantially lower levels of ISGs with WT NF- κ B target were upregulated in both that type I IFN pathway was in autoantibody production but NF- κ B activation was sufficient for development of glomerulonephritis. These results demonstrate a specific requirement for IRF7 in autoantibody production against the DNA- and RNA-containing antigens and autoantibody production and lupus nephritis are controlled by separate mechanisms in this model. Atopic dermatitis (AD) and psoriasis are characterized by T-cell infiltration in skin lesions, but their comparable systemic T-cell activation is unclear. We compared T-cell activation and cytokine producing cell-frequency in blood of adult AD and psoriasis patients using flow-cytometry. We measured cytokines, T-regulatory cells (Tregs) and T-cell activation markers in central and effector memory (Tcm and Tem) skin homing/cutaneous lymphocyte antigen (CLA + ) and CLA - subsets from 24 psoriasis patients, 35 AD patients and 13 controls. Early (CD69), mid (ICOS) and late (HLA-DR) activation markers were quantified in Tcm (CCR7 + CD45RO + ) and Tem (CCR7 - CD45RO + ) popula- tions. AD showed higher frequency of CLA + "polar" T-cell subsets (p<0.0001). In both diseases, CLA + T-cells were significantly more activated compared to respective CLA - subsets (p<0.01), suggesting their prominent role in inflammatory skin diseases. AD demonstrated higher levels of ICOS/HLA-DR activation in circulating CLA + and CLA - memory subsets (p<0.01). CD69 was the only activation marker that was higher in psoriasis (p=0.001), whereas ICOS expression was significantly higher in AD (p<0.0001), compatible with their respective roles in Th17 and Th2 responses. Significant correlations with SCORAD were observed in AD, particularly striking for ICOS (r=0.5, p<0.01). Higher CD25 + CD127 - CCR4 + CLA + Tregs were found in AD, correlating with SCORAD and IgE. Compared with psoriasis, AD is characterized by increased polar differentiation of Tcm/Tem subsets, with higher, and persistent activation parti


Objective To investigate the layout design of out-patient clinical laboratory and the process optimization of chemical examination,and to improve our service capability and patient satisfaction.Methods Based on sector standards,studying the design of internal and abroad advanced experience of clinical laboratory,meeting the need of out-patient clinical laboratory's function,to make patient more comfortable and thoroughly to embody the concept,that is the people-oriented,barrier-free communication,equal service,we make a design of the out-patient clinical laboratory layout and process.Results We have changed the situation in the past,that is unreasonable layout,unscientific window set,unsmooth process,crowded patient and low satisfaction.Moreover,a completely new out-patient clinical laboratory was designed which has scientific layout,smooth process,spacious and comfortable room and humanization.We also reach the goal of controlling bio-safety through scientific partition,safe and effective spatial isolation and the application of relevant bio-security facility.Conclusion As an important window to communicate doctors and patients,the scientific design of out-patient clinical laboratory layout and process directly determines its service capability and patients' reception.


The Schottky barrier diodes of sputtered TiNx on n-type silicon have been prepared by an RF-DC coupled magnetron sputtering system which employs a low RF power and DC bias. The electrical properties of TiNx/Si system prepared by this method have been investigated. It was found that the TiNx/Si system prepared at the target DC bias voltage of-100 V have the Schottky barrier with low sputtering damage where the Schottky barrier height is 0.56 eV. It was suggested that the RF-DC coupled magnetron sputtering is useful for preparation of the Schottky barrier diode.


This study aims to show that the product proliferation strategy in multi‐product duopoly is first‐mover advantage. We consider simultaneous and Stackelberg variety competitions. A firm producing more varieties charges a higher price, produces larger total quantities, and earns higher total revenue. When firms sequentially choose the masses of varieties and then simultaneously decide prices, the leader produces more varieties and enjoys first‐mover advantage. The masses of varieties can be regarded as strategic substitutes in the same way that quantities are. Finally, the market is likely to provide too few varieties relative to the social optimum.


The porcine pancreas lipase(PPLipase) was modified by Tween40,Sucrose ester S970 and Span60 in aqueous solution,and then the Tween40-PPLipase,S970-PPLipase and Span60-PPLipase were used to catalyze the interesterification of camellia and linoleic acid in solvent free system. The results indicated that the acyl incorporation(Ia) was increased with the enzyme loading increasing before the reaction balance reached.The interesterification volecities of the reactions catalyzed by Tween40-PPLipase,Span60-PPLipase and S970-PPLipase were higher than that catalyzed by PPLipase when the enzyme loadings were same. At enzyme load 5% level,the Ia of the interesterifiecation catalyzed by PPLipase was 16.1% at 2h,however the Ias of the interesterification catalyzed by Tween40-PPLipase,Span60-PPLipase and S970-PPLipase were 20.4%,21.1% and 22.4%,respectively. When the reaction balance reached,the Ias of the interesterifications catalyzed by Tween40-PPLipase,S970-PPLipase,Span60-PPLipase and PPLipase were same roughly,about 25%.


Background: Excessive hyperbilirubinemia is potentially neurotoxic and can lead to long-term complications in neonates. Exchange transfusion (ECT) is one of the important treatments for hyperbilirubinemia. The main goal of this study is to determine the maternal and neonatal characteristics of hyperbilirubinemia in infants in need of exchange transfusion.Methods and materials: This cross-sectional study was performed on 380 infants over 35 gestational weeks, 2 to 14 days old, with bilirubin above 17 mg/dl who had undergone ECT at Ghaem Hospital of Mashhad from 2010 to 2020. In this study, neonates in need of ECT were selected using available sampling method. The checklist form was designed based on neonatal examination, maternal (maternal age, parity), and neonatal status (age, sex, weight) and serial laboratory tests before and after ECT (total bilirubin, hematocrit, and platelet). Then, these variables were compared based on the cause of hyperbilirubinemia.Results: The mean bilirubin serum level was 28.5 mg/dl in male and 26.5 mg/dl (P = 0.096) in female infants, 29.5 mg/dl in the C-section and 28.1 mg/dl (P = 0.458) in normal vaginal delivery. Sixty percent of the neonates suffered from weight loss and 22% had more than 3% daily weight loss. In our study, infants first presented RH incompatibility and then ABO incompatibility and finally G6PD deficient neonates.Conclusion: Overall, these finding suggest that normal vaginal delivery, repeated breastfeeding, prevention of severe weight loss, early detection of RH & ABO incompatibility and G6PD deficiency, as well as appropriate management of hyperbilirubinemia may reduce both the need for ECT and alleviate complications of neonatal hyperbilirubinemia.


1-Introduction Trisomy 22 is the second most common autosomal trisomy, after trisomy 16, present in miscarriages, accounting for 3 to 5% of all spontaneous abortions [1]. However, the children born with trisomy 22 are relatively rare and have usually unbalanced translocations t (11; 22) or mosaicisms. In this study, we describe a new case of mosaic trisomy 22 in a female malformed newborn who died three month after birth. 2-Case report Our patient was the third child of a healthy nonconsanguineous couple. The father was 36-years old. The mother was 35-years old, gravida five and para three. Two previous pregnancies ended in miscarriages. The girl was born at term (37 weeks of a normal gestation) by spontaneous vaginal delivery. Her birth weight was 1520 g (<3rd centile), her length was 39cm (<3rd centile), and her FOC measured 29cm (<3rd centile). She was noted at birth to have growth retardation and dysmorphic features. Re-evaluation at the age of 1 month showed other clinical features, including hypotonia, psychomotor retardation, heart defects, and urogenital anomalies. At dysmorphological examination, craniofacial features included microcephaly, large anterior fontanelles and widely patent cranial sutures, abnormal posteriorily rotated ears with bilateral preauricular pits and sinus, hypertelorism and downward slanting palpebral fissures, bilateral blepharoptosis and scarce eyebrows. The nose was short and beaked with a flattened nasal bridge, anteverted nares and irregular ear canal. Further findings were a long philtrum, thin lips, Summury:


A new model accounting for the ac impedance spectra of synthetic ion-exchange bipolar membranes is presented. The theoretical approach is based on the Nernst−Planck and Poisson equations and applies some of the concepts used in the semiconductor pn junctions to the case of a bipolar membrane. The results presented are the current−voltage curves and the impedance spectra at electric currents above the limiting current. It is shown that the model is able to identify the main contributions to the bipolar membrane impedance and gives valuable information about the bipolar junction structure and its influence on the characteristic parameters involved in the field-enhanced water dissociation phenomenon.


Johnston Minor (now Deputy Keeper of H.M. Signet) who was a chum of mine in Hartnell's house in the junior school. I cannot recall that at school he was much of a cricketer?certainly never so good as his younger brother became?but his sturdy build rciade him a pretty useful forward in the Rugby football field. His best performances were in the " Gym.," where he led the upper school team in feats of strength and skill over the wooden horse, along the swinging rings, and on the horizontal and parallel bars. In later days ^ often thought that his school nickname?which his contemporaries will remember?was not inappropriate as a description of one who had always a solid and substantial air, took his own line, was not easily deflected it, and generally got what he wanted. I did not meet Johnston again until I began to study medicine ln 1879, when he was dresser or clerk to Mr John Duncan, the SUrgeon. Johnston took his M.B., C.M. in 1881, two years ahead me, but we used to meet at his mother's hospitable house in ?Jutland Square, and at the Royal Medical Society on Friday evenings, where he soon made his mark, especially in private business, and was ?ventually Senior President. Johnston became House Surgeon to John Duncan. He took his ^?D. in 1883, and the Fellowship of the Royal College of Surgeons in the following year. Commencing as a general practitioner, he was s?on appointed Physician to the Sick Children's Hospital, but having made up his mind to become a specialist, he took up work in the Ear, ^?se and Throat Department and was appointed Assistant Surgeon t? Dr Peter M'Bride in the Royal Infirmary in 1890. In 1903 he was promoted to a full Surgeoncy, but had only, served for three years when a small growth on one of his vocal cords


Seismic isolation design of multi-storey building is performed in this paper.Nonlinear time-history analysis is adopted in the isolator structure design.The calculating result indicated that seismic acceleration and displacement response of isolated structure significantly decreases.Application of base isolation system can ease the reaction and the harm of structure availably under earthquake.


The Centers for Disease Control and Prevention has asked all HIV prevention grant recipients to review their HIV/AIDS prevention materials to make certain these meet the CDC's requirements. Here is an abridged reprint of what's in the guidelines.


Maritime transport service trade is the important part of international service trade. Since China's accession to the WTO, the government has been making efforts in the fulfillment of commitments in the field of international maritime transport service, supplementary service of maritime transport, container service, agency services of maritime transport, and cabotage right. To promote the liberalization of maritime transport service trade, we should keep the profile of moderate fashion and master the initiative in the bilateral and multilateral negotiation of maritime transport service trade.


The past thirty years have seen an explosion in the use of Monte Carlo methods for statistical inference, with an important advance being the use of population Monte Carlo (PMC) methods, which use of a population for exploring the search space. Despite their success in statistics, PMC methods have received less attention in the field of optimization. This paper begins by introducing population Markov chain Monte Carlo (MCMC) [10, 20]; and sequential Monte Carlo (SMC) [6, 12], then describes the use of interval arithmetic to aid these algorithms. In this paper, through showing how interval arithmetic may be used within PMC algorithms, we obtain methods that combine the useful properties of both PMC and internal arithmetic.


We report a theoretical study of the coherence dynamics of spin qubits in two-dimensional materials (2DMs) and van der Waals heterostructures, as a function of the host thickness and the composition of the surrounding environment. We focus on MoS2 and WS2, two promising systems for quantum technology applications, and we consider the decoherence arising from the interaction of the spin qubit with nuclear spins. We show that the Hahn-echo coherence time is determined by a complex interplay between the source of decoherence in the qubit host and in the environment, which in turn determines whether the noise evolution is in a classical or quantum mechanical regime. We suggest that the composition and thickness of van der Waals heterostructures encapsulating a qubit host can be engineered to maximize coherence times. Finally, we discuss how quantum sensors may be able to probe the dynamics of the nuclear bath in 2DMs.


The transient optical gain was quantitatively determined from the rise time of output pulses of a gain-switched semiconductor laser via impulsive optical pumping. The optical gain for a high carrier density during gain switching was greatly reduced from that during steady-state operation because of hot carriers.


National security strategies like gamma spectroscopy and high-energy X-ray radiography are limited, in part, by the scintillator used, prompting research into novel materials with improved properties. In this work, Eu<inline-formula> <tex-math notation="LaTeX">$^{2+}$ </tex-math></inline-formula> activated rubidium calcium bromide scintillators were grown via the vertical Bridgman method with a range of dopant concentrations. Light yield, energy resolution, and the afterglow of Rb4CaBr6:Eu and RbCaBr3:Eu improved with increasing Eu<inline-formula> <tex-math notation="LaTeX">$^{2+}$ </tex-math></inline-formula> concentration, and scintillation decay time increased. The highest light yields of Rb4CaBr6:Eu and RbCaBr3:Eu were 71000 and 45000 ph/MeV, respectively.


Abstract. There is increasing evidence that phosphorus (P) can be transferred to surface waters by leaching as well as by erosion and surface runoff. Recently it has been suggested that P soluble in 0.01 m CaCl2 may be a good indicator of the specific Olsen‐P concentration (usually termed the 'Change Point') at which the rate of P leaching from soil suddenly increases and poses a greater threat of eutrophication to standing waters. We know that these 'Change Points' vary from soil to soil but, so far, we do not fully understand the mechanism(s) involved. Here, we combine methods for assessing isotopically exchangeable P and P sequential fractionation to gain an insight into the processes which cause this sudden increase in P solubilization. We suggest that Change‐Points simply define the asymtote of rapid desorption isotherms relating to that P which is most readily isotopically exchangeable (i.e at 24 h –33P24) with the soil solution. This involves ligand exchange at hydroxyl sites associated with Fe and Al cations, which is kinetically governed by the concentration of surface complexes on soil minerals. Individual Change‐Points reflect the mineralogy and surface chemistry of different soil types. Laboratory and field measurements of the Olsen‐P Change‐Point reflect these surface phenomena and are similar. Olsen‐P extracts the portion of the exchangeable pool that most readily controls solution P, and the Olsen‐P/33P24 ratio is linearly related to Olsen‐P Change‐Points. This may provide a method for estimating P Change‐Points where gradients of soil P are not available.


Wall shear stress measurements utilizing hot-film anemometry in a high Reynolds number laboratory pipe flow (RRRR = 1.7 × 106) retarding to a complete rest have been presented. The purpose of the measurements was to investigate the level of unsteadiness in the wall shear stress during a Gibson (hydropower flow rate) measurement. The ensemble-averaged wall shear stress from 44 repetitions has been compared with the results obtained from both the 'standard', the 'unsteady' transient Gibson method, and a quasi-steady Gibson approach. The results show very small differences between the measured wall shear stress and the estimated values. The small deviations between the standard Gibson method and the measured values are encouraging. For, if transient modeling of the wall shear stress can be avoided, this would be beneficial because any empirical parameter entering a transient formulation must, inevitably, be experimentally calibrated at Reynolds numbers much smaller than those encountered in a typical Gibson measurement, thus introducing uncertainties regarding the extrapolation of such models to high Reynolds numbers. Albeit being a large Reynolds number in the lab scale, RRRR = 1.7 × 106 is still one or two orders of magnitude smaller than that typically encountered in hydropower. Thus, direct transfer of the present result to a full scale measurement cannot be done without further studies. More detailed processing of the present data, as well as studies of five other sets of measurements are underway and will be presented elsewhere.


This article represent effort to reflect again how far the 1945 Constitution of the Republic of Indonesia have guaranteed constitutionality function and authority of Vice President of Republic of Indonesia as "assistant" President which still there are dimness or ill defined norm (vague van normen) and also continuous to become polemic. The 1945 Constitution of the Republic of Indonesia do not give clear arrangement, adequate and coherent about how in fact form relation mechanism work and division of authority between Presidents with Vice President which have been elected as a single ticket directly by the people, considering that Vice President is "partner which is image" with President because both have been elected as a single ticket directly by the people. Including the Article 4 Paragraph 2 the 1945 Constitution of the Republic of Indonesia does not give interpretation of authentic concerning term "The President shall be assisted by a Vice President".


As directed in Public Law 100-657, Commercial Space Launch Act Amendments of 1988, and consistent with National Space Policy, NASA has prepared a report on a potential program of research on technologies to reduce the initial and recurring costs, increase reliability, and improve performance of expendable launch vehicles for the launch of commercial and government spacecraft into orbit. The report was developed in consultation with industry and in recognition of relevant ongoing and planned NASA and DoD technology programs which will provide much of the required launch systems technology for U.S. Government needs. Additional efforts which could be undertaken to strengthen the technology base are identified. To this end, focus is on needs for launch vehicle technology development and, in selected areas, includes verification to permit private-sector new technology application at reduced risk. If such a program were to be implemented, it would entail both government and private-sector effort and resources. The additional efforts identified would augment the existing launch vehicle technology programs. The additional efforts identified have not been funded, based upon agency assessments of relative priority vis-a-vis the existing programs. Throughout the consultation and review process, the industry representatives stressed the overriding importance of continuing the DoD/NASA Advanced Launch Development activity and other government technology programs as a primary source of essential launch vehicle technology.


We studied the physical meaning of tidal force singularities in non-relativistic spacetimes. Typical examples of such spacetimes include Lifshitz spacetimes, Schr\"{o}dinger spacetimes and hyperscaling violation spacetimes. First I will discuss the extension of singularity-free hyperscaling violation geometry. To understand the physical meaning of singularity in the deep non-relativistic IR bulk, I will calculate string scattering amplitudes to find a field theory interpretation of bulk singularity. Since geometric quantities like singularities or horizons are not physical observables in higher spin theory, we will discuss whether it is possible to resolve such singularities in non-relativistic spacetimes from higher spin theory context. We will show singularity resolution cannot be performed in $2+1$ dimensional higher spin theory. Finally, we will give an explicit construction of Schr\"{o}dinger spacetime solutions in $3+1$ dimensional higher spin theory.


A versatile interface card for Apple IIe computer and various peripheral devices are designed to control instruments which generates transient signals like in graphite furnace atomic spectrometer. The interface card consists of a multiplexed analog‐to‐digital converter, a digital‐to‐analog converter, and a timer/counter chip. The timer/counter chip with 16 built‐in registers can be programmed in many modes which provides a time base for real‐time measurements. A stepper motor runs under the control of timer/counter chip independent of computer. A light chopper connected to the stepper motor is controlled easily by computer. A dual high‐voltage switch can modulate dc light sources under computer control. This system is applied to D2‐lamp background correction graphite furnace atomic absorption spectrometer. The D2 lamp is chopped by a mechanical chopper driven by a stepper motor and a hollow cathode lamp is modulated electronically. The data acquisition program is written in machine language and synchroniz...


From her own life experience and the then status quo of her time,the English writer Jane Austin depicted marriage and love which presented the budding female awarenss and embodied the narrative expression with female features.Characters depicted in her works are not formatic but of distinctive personalities.In her works,she employs the rhetoric means of irony in her depiction of characters,scenes and the whole plot designing,which makes it possible for her readers to feel her humor and irony.


Mercury (Hg) exposure in human infants and fetuses has long been known to be significantly associated with neurodevelopmental disorders (NDs). Thimerosal (49.55% Hg by weight) is an ethyl-Hg containing compound added to many childhood vaccines as a preservative. A hypothesis testing case-control study was undertaken in the Vaccine Adverse Event Reporting System (VAERS) database (updated through September 2013) by examining 5,591 adverse event reports entered following Thimerosal-preserved Diphtheria-Tetanus-acellular-Pertussis (DTaP) (Tripedia TM , Sanofi) administered from 1997-1999 (exposed) and following Thimerosal-reduced DTaP (Tripedia TM , Sanofi) administered from 2004-2006 (unexposed). Cases were defined as individuals with adverse event reports with the outcomes of autism, speech disorder, mental retardation, or ND (at least of one these aforementioned specific outcomes being mentioned in the adverse event report). Controls were defined as individuals with adverse event reports without any mention of the specific case outcomes examined. Cases reported with the outcomes of autism (odds ratio = 7.67, p < 0.0001), speech disorders (odds ratio = 3.49, p < 0.02), mental retardation (odds ratio = 8.73, p < 0.0005), or ND (odds ratio = 4.82, p < 0.0001) were significantly more likely than controls to have received Thimerosal- preserved DTaP vaccine (exposed) in comparison to Thimerosal-reduced DTaP vaccine (unexposed). Though routine childhood vaccination is considered an important public health tool to reduce the morbidity and mortality associated with certain infectious diseases, this study supports a significant relationship between increased organic-Hg exposure from Thimerosal-preserved childhood vaccines and the child's subsequent risk of a ND diagnosis.


At the suggestion of Reza Langari and John Yen, we announced a special session devoted to applications of interval methods to expert systems and fuzzy control. The number of contributors exceed our expectations, so at the conference, we had three sessions (out of 24) devoted to filzzy intervals. These sections were chaired Several interval-related papers were presented at other sessions. Totally, interval papers were authored by 27 authors from 8 countries: These sessions were atteilded by leading researchers in the field, and we hope" that the~' further promoted the understanding between the interval and the expert system communities. A well-organized social program, that included a boat tour of the San Antonio Riverwalk, a walking tour of the Alamo (the "Shrine of Texas Freedom"), and a bus tour of the Old City, definitely helped researchers to make informal contacts. Why fuzzy intervals? One of the main applications of expert knowledge is intdligenl control. In many cases, we want to design an automated controller, but do not know the exact behavior of the controlled plant, and we cannot therefore use traditional control techniqnes, In such cases, we often have the expertise of human controllers who know how to control the plant (e.g., how to drive a car, how to ride a plane, etc). These experts cannot formulate how exactly they control in exact terms. Instead, they can formulate their expertise in terms of "if-then" rules of the type: "if the obstacle is nearby, and you are driving with a moderate speed, hit the breaks immediatelyL There exists a methodology that transforms experts' rules, formulated in terms of words of a natural language, into a precise control strategy. This methodology is called fuzzy conlrol (see, e.g., [9]). Fuzzy control technique starts with determining the values of the membership fimctions #~(:r) that correspond to different words used in the rules. Namely, the value /~a(:r) represents the expert's degree of belief that a value :r satisfies the property A. Then~ it computes the degrees of belief in composite statements, and in particular, computes, for each


Thin films, containing fluorocarbons and sulphonic acid groups, were prepared by plasma polymerisation of 1,3‐butadiene/CF3SO3H and styrene/CF3SO3H mixtures using two different types of plasma discharges. The morphology, density, and chemical composition of the synthesised plasma polymers were examined by SEM, small‐angle X‐ray reflectometry, and FTIR and XPS analyses, respectively. Proton conductivity was measured with electrochemical impedance spectroscopy. The prepared films are relatively uniform and free from defects. Plasma materials exhibiting higher sulphonic acid group contents and lower densities are those formed, from the styrene/CF3SO3H mixture, in the after glow discharge configuration; which proves that the kind of discharge and the nature of the monomer mixture have a large influence on the microstructure of plasma materials. Consequently, plasma films, prepared in the after glow discharge from the styrene/CF3SO3H mixture, show proton conductivities (up to 9.8 × 10–2 mS cm–1) about one order of magnitude higher than films prepared in the glow discharge (up to 2.2 × 10–3 mS cm–1 and 2.5 × 10–3 mS cm–1 for films prepared from 1,3‐butadiene/CF3SO3H and styrene/CF3SO3H mixtures, respectively). When compared to the commercially available Nafion®, the reference electrolyte polymer in the PEMFC, our most competitive plasma polymers are intrinsically 100 times less conductive. Nevertheless, due to their thinness (about 1 μm), these plasma films show specific resistances (about 1.0 Ω cm2), which are lower than that of the Nafion® membrane (1.9 Ω cm2 specific resistance). This explains their potential significance as polymer electrolyte membranes in a miniaturised PEMFC.


Kura clover living mulch (KCLM) systems have been previously investigated for their incorporation into upper Midwestern row crop rotations to provide ecosystem services through continuous living cover. Reductions in soil erosion and nitrate loss to surface and groundwater have been reported, but factors affecting agronomic performance and nutrient management are not well defined. To achieve realized environmental benefits, research must develop agronomic management techniques, determine economic opportunities, and provide management recommendations for row crop production in KCLM systems. Two experiments were conducted in 2017 and 2018 to determine the response to N fertilizer application for maize production in KCLM. The first-year maize experiment followed forage management, and the second-year maize experiment followed maize after forage management. Eight fertilizer N treatments ranging from 0–250 kg N ha−1 were applied to each experiment and grain and stover yields were compared to conventionally managed maize hybrid trials that were conducted nearby. First-year maize did not need fertilizer N to maximize yield and profitability in either growing season, and second-year maize required a fertilizer N rate near local University guidelines for maize following soybean. The net economic return from maize grain and stover in the KCLM averaged over first and second-year maize experiments and 2017 and 2018 growing seasons were $138 ha−1 greater than the conventional comparison.


Diblock copolymer poly(ethylene glycol) methyl ether–polylactide (MePEG–PLA) micelles were prepared by dialysis against water. Indomethacin (IMC) as a model drug was entrapped into the micelles by dialysis method. The critical micelle concentration (CMC) of the prepared micelles in distilled water investigated by fluorescence spectroscopy was 0.0051 mg/mL which is lower than that of common low molecular weight surfactants. The diameters of MePEGPLA micelles and IMC loaded MePEGPLA micelles in a number-averaged scale measured by dynamic light scattering were 52.4 and 53.7 nm respectively. The observation with transmission electron microscope and scanning electron microscope showed that the appearance of MePEGPLA micelles was in a spherical shape. The content of IMC incorporated in the core portion of the micelles was 18% (ω). The effects of the synthesis method of the copolymer on the polydispersity of the micelles and the yield of the micelles formation were discussed.


meishan City: located on the southwest rim of Siehuan Basin. Area: 1170 square kilometers. Ad ministration: 12 towns and 4 townships. Pop: 400,000. Emeishan City enjoys rich resourses. Mineral resourses include: coal, iron, copper, limestone, dolomite, phosphorus, calcite, K-f-eldspar, quartzite, marble, granite. Agriculturally, rice, wheat and corn are the main produce. There is a complete subdivision of industry: metallurgy, electricity, coal, chemistry, machinery, building materials, forest resourses, food, weaving, sewing, leather, pa-per-making, office materials, medicine, electronics and mining. Emeishan City is 130 kilometers from Chengdu and enjoys the convenience of railway, highways and airlines. Communication facilities are well developed, and science and technology well established. Emeishan City sincerely welcomes friends from this country and abroad to invest and share benefits. Investment Liaisons: Chen Bolun (Mayor) Tel; (08426) 22900(off) 23944 (Res) Postcode: 614200


The association of invertebrates in Ogbe creek with Ipomea aquatica was investigated within the period from 7 th September to 30 th November, 2001. 167 invertebrates comprising of 19 species were harvested from 73 weeds. Corixa punctata (22.16%) was the most abundant invertebrate on Ipomea aquatica while Gvrinus notator larvae (0.60%) were the least abundant. The roots sheltered the highest number of invertebrates (113), comprising of 12 species recording a species diversity of 5.36 while the stem sheltered the lowest number of invertebrates (10) comprising of 3 species with a species diversity of 2.00. The ability of Ipomea aquatica to harbour invertebrates was influenced by the morphological form of the plant. The root was the preferred site for the invertebrates because it was a suitable substrate for clinging and nutrient supply.


The present invention relates to a process for metathesis butene-hexene, low catalyst activity mainly to solve the problems in the conventional art. The present invention, by using 1-butene as raw materials, in a fixed bed reactor, the reaction temperature is 300 ~ 450 ℃, reaction pressure in terms of absolute pressure of 0 ~ 2MPa, 1- butene WHSV of 4 to 20 hours -1 conditions, feed and catalyst contacting reaction product effluent comprising hexene, wherein the catalyst used in parts by weight, comprising the following components: a) 5 ~ 50 parts of tungsten oxide; b) 50 ~ 95 parts by oxidation magnesium support technical scheme solves the problem, it can be used in industrial production of hexene-butene metathesis.


Modern problems of socioeconomic system potential management have been studied. The principles of creation the potential management concept have been formulated.


Due to the growing share of converter fed loads and converter coupled distributed generation units in the distribution network, power quality issues become more and more important. The behavior of the existing converters, in most cases peak rectifiers, may result in a distorted network voltage. The recent interest in power factor correction converters shows the importance of resistive converter behavior. Resistive converters damp network oscillations, but their damping potential is dependent of their power level. Power factor correction converters with a programmable damping resistance as secondary control function can be used to reduce the voltage distortion on the grid independently of their power level. With these converters it is possible to set a harmonic input resistance independent of the fundamental input impedance. Consequently, the harmonic input resistance remains low, even when the input power of the converter is decreased. Most attention is paid to the damping of voltage harmonics. However, this control strategy allows also to mitigate voltage dips. Experimental tests on a 1 kW prototype of a digitally controlled full bridge bidirectional converter show the practical behavior of the algorithm. The reaction of the control algorithm on voltage harmonics and voltage dips is examined.


The survival of high Z nuclei in the X-ray photon field of a pulsar is investigated. For heavy nuclei with energies greater than or equal to 100 GeV/nucleon, 100 keV X-ray photons have sufficient energy to cause photodisintegration with cross sections of approximately 10 to the minus 25th power sq cm. Using the observed properties of the Crab pulsar, extrapolation back to epochs when the pulsar was more active indicates that the photon field is sufficiently dense to prevent the acceleration of heavy nuclei within the velocity of light cylinder. On this model, the upper limit on the energy of the escaping nuclei varies with time. The models for cosmic ray acceleration in supernova explosions or by pulsars will be related to experimental observations.


Modern server-class systems are typically built as several multicore chips put together in a single system. Each chip has a local DRAM (dynamic random-access memory) module; together they are referred to as a node. Nodes are connected via a high-speed interconnect, and the system is fully coherent. This means that, transparently to the programmer, a core can issue requests to its node's local memory as well as to the memories of other nodes. The key distinction is that remote requests will take longer, because they are subject to longer wire delays and may have to jump several hops as they traverse the interconnect. The latency of memory-access times is hence non-uniform, because it depends on where the request originates and where it is destined to go. Such systems are referred to as NUMA (non-uniform memory access).


INTRODUCTION: Congenital hypothyroidism is the most common preventable cause of mental retardation. Features of congenital hypothyroidism are nonspecific and difficult to identify in the neonatal period. They become prominent with increasing age. However the window period for neurological intervention has elapsed in most patients by this time. The female to male ratio is 2:1. If congenital hypothyroidism is diagnosed promptly and treated early irreversible mental retardation can be prevented. AIMS AND OBJECTIVES:The aim of neonatal screening program is to detect affected neonates and provide replacement to them as early as possible so that severe physical and mental handicap can be prevented by early treatment.To evaluate the effectiveness of cord blood TSH screening to detect cases with hypothyroidism. METHODS: A cross sectional study conducted on babies born in department of obstetrics and gynaecology,RIMS Ranchi. Umbilical cord blood sample was collected in a sterile container drawn from the umbilical cord incised at the time of birth. TSH level was estimated within 24 hours by chemiluminescent microparticle immunoassay (CMIA) method in department of laboratory medicine/biochemistry RIMS,Ranchi. RESULT: Number of confirmed case of congenital hypothyroidism was 1/200 . There were total 7 cord blood samples whose TSH values ≥20mIU/L but a repeat test on 2-4 days of life confirmed CH in one of these samples. Mean TSH value female was 7.27± 0.89mIU/Lwhile mean TSH value for male was 6.89±0.38mIU/L. Mean TSH value for preterm was 10.99±0.62mIU/L. Mean TSH value for term was 6.81±0.60mIU/L. Mean TSH value for post term was 4.38±0.75mIU/L. DISCUSSION: Present study was carried out in the department of Pediatrics and neonatology,RIMS,Ranchi. TSH cut off values for screening of neonates: Initial TSH value≤10 mIU/L-Normal Initial TSH value 10.119.9mIU/LBorderline Initial TSH value ≥20 mIU/LAbnormal These studies need larger sample size and stronger logistic effort with team approach.7.5% of newborns in our series had values between 10.119.9mIU/L.This is the group which needs further evaluation to confirm thyroxine deficiency either acquired or congenital. CONCLUSION: Due to the practice of early discharge in our country cord blood estimation remains a very practical method for screening purpose.Use of cord blood TSH as a screening tool is an attractive method because of its simplicity and accessibility.The Indian Academy of Pediatrics recommends the use of cord blood samples for screening for congenital hypothyroidism.


Last time, we introduced the Vickrey auction and proved that it enjoys three desirable and different guarantees: (1) [strong incentive guarantees] DSIC. That is, truthful bidding should be a dominant strategy (and never leads to negative utility). Don't forget the two reasons we're after the DSIC guarantee. First, such an auction is easy to play for bidders — just play the obvious dominant strategy. Second, assuming only that bidders will play a dominant strategy when they have one, we can confidently predict the outcome of the auction. (2) [strong performance guarantees] Social surplus maximization. That is, assuming truthful bids (which is justified by (1)), the allocation of goods to bidders should maximize n i=1 v i x i , where x i the amount of stuff allocated to bidder i. (3) [computational efficiency] The auction can be implemented in polynomial (indeed, linear) time. To extend these guarantees beyond single-item auctions to more complex problems, like the sponsored search auctions introduced last lecture, we advocated a two-step design approach. Step 1: Assume, without justification, that bidders bid truthfully. Then, how should we assign bidders to slots so that the above properties (2) and (3) hold? Step 2: Given our answer to Step 1, how should we set selling prices so that the above property (1) holds? * c 2013, Tim Roughgarden. These lecture notes are provided for personal use only. See my book Twenty Lectures on Algorithmic Game Theory, published by Cambridge University Press, for the latest version.


In recent years we have come to hear the phrase 'focus on the learner' more and more. Teachers are exhorted to promote student-centered learning, where the teacher assumes a role that is not so much the giver of knowledge as the facilitator in students' discovering that knowledge themselves. The details of just how the teacher is to do this effectively are often much more sketchy than the details of why she/he should. And for some of us as teachers, there is that little inner fear that the class will founder if we are not obviously at the helm every minute during the class. How can we 'let go' of our students, while providing meaningful and structured activities for them?


Abstract Electrochemical hysteresis techniques may be used to construct experimental potential versus pH diagrams for alloy systems. Examples presented include binary alloys of the Fe-Cr and Cu-Ni systems. Such diagrams are a valuable alloy development tool since they provide a basis for comparison of the corrosion behavior of several alloys in a family of alloys. It is also possible to present relative corrosion rates for the alloys as iso-corrosion contours on pH versus potential coordinates. The influence of variation in chloride ion activity on the corrosion behavior of Fe-Cr alloys is expressed in terms of influence on zero current potentials, passivation potentials, protection potentials, and rupture (pitting) potentials. From an engineering standpoint, the protection potential appears to offer certain advantages over the pitting potential for the Fe-Cr alloys.


Professor Alan Glasper discusses the Royal College of Nursing's red-light warning to the profession following the publication of the long-awaited Francis report


This paper provides a new paradigm for thinking about performance fees. Closed-form expressions for the value and expected value of the performance fee for a popular generic structure are presented. The expected fee is decomposed into earned and unearned components. Suggestions for reducing the expected unearned performance fee are provided. It is shown that the expected unearned performance fee can be reduced substantially with simple procedures. Finally, it is shown for another popular fee structure that the expected unearned performance fee can be negative for talented managers. The paradigm is easily generalized to other performance fee structures.