In this work we propose a laser diode pulse modulation algorithm suitable for implementation in microcontrollers. This algorithm overcomes the speed limitations in microcontroller based laser pulse drivers. A feed forward signal is added to a proportional integral and differential (PID) feedback signal after a settling time. The initial feed forward control gives a fast rise time (<5 μs) and the PID feedback ensure immunity to drift for large pulse widths. This algorithm enables a settling time 10 times faster than the PID settling time. The controller is self-learning and updates the feed forward estimator based on the settled feedback control output. The use of pulse width modulation (PWM) for digital to analog conversion scales well to high power laser diodes due to its high efficiency.


BEST family is a class of Ca2+-activated Cl-channels evolutionary well conserved from bacteria to human. The human BEST paralogs (BEST1-BEST4) share significant amino acid sequence homology in the N-terminal region, which forms the transmembrane helicases and contains the direct calcium-binding site, Ca2+-clasp. But the cytosolic C-terminal region is less conserved in the paralogs. Interestingly, this domain-specific sequence conservation is also found in the BEST1 orthologs. However, the functional role of the C-terminal region in the BEST channels is still poorly understood. Thus, we aimed to understand the functional role of the C-terminal region in the human and mouse BEST1 channels by using electrophysiological recordings. We found that the calcium-dependent activation of BEST1 channels can be modulated by the C-terminal region. The C-terminal deletion hBEST1 reduced the Ca2+-dependent current activation and the hBEST1-mBEST1 chimera showed a significantly reduced calcium sensitivity to hBEST1 in the HEK293 cells. And the C-terminal domain could regulate cellular expression and plasma membrane targeting of BEST1 channels. Our results can provide a basis for understanding the C-terminal roles in the structure-function of BEST family proteins.


This report is part of a joint global research, development and demonstration effort of the United Nations Development Programme and the World Bank. It reviews current literature and practices on the co-composting of human waste together with the organic fraction of domestic solid waste. The report describes the composting process, reviews various co-composting systems, and discusses health aspects such as pathogen destruction. The uses of compost as a soil conditioner, mulch, fertilizer or for land reclamation are also described. The report also develops several cost/benefit models for economic analysis of co-composting operations and outlines the economics of the process as a whole. The focus of the analytical methodology is on developing countries. Key issues for consideration in planning for composting are also discussed. Decision makers and planners will find this report a valuable reference on co-composting when addressing waste management and resource recovery issues in the developing countries.


A survey conducted in ten countries found that between 13 and 62 percent of women have experienced physical abuse by a partner over the course of their life time and between 3 and 29 percent of women reported violence within the past year. The aim of this study was to profile abused women who consulted at Daveyton Clinic in Ekurhuleni Metropolitan Municipality over a period of two year. A survey of medical records of women who consulted at the Clinic from January 2008 to December 2009 was conducted. From the 1500 medical records, 271 specifically gave abuse as a diagnosis and were included in the study for review. Twenty records were used to pilot the data abstraction tool and the rest of the records (n=251) were included as the study sample. Overall prevalence of abuse in the clinic was 18%. Prevalence of sexual abuse in the two year period was 16.7%. Approximately three quarters of the sample (72.8 %) were 30 years or younger (four women's age were not recorded). The average age of the women was approximately 27 years (SD = 8.8 yrs). Almost 60% of the women were single, the majority (88.8 %) had secondary education. About 45% of the cases were unemployed and 15% were students which means that 60% of the sample were economically inactive. More than two-thirds (67.7 %) of the abuse reported was during the festive season and more than half (59.8 %) was reported at night. Majority of these women were abused by their husbands or partners. Emotional and physical abuse was the most common form of abuse among these women. Abuse was common among women under the age of 30 years, with secondary education or less, with the majority of women being in school, unemployed and economically inactive.


We present a general computational framework that enables one to generate realistic 3D microstructure models of heterogeneous materials from limited morphological information via stochastic optimization. In our framework, the 3D material microstructure is represented as a 3D array, whose entries indicate the local state of that voxel. The limited structural data obtained in various experiments correspond to different mathematical transformations of the 3D array. Reconstructing the 3D material structure from such limited data is formulated as an inverse problem, originally proposed by Yeong and Torquato [Phys. Rev. E 57, 495 (1998)], which is solved using the simulated annealing procedure. The utility, versatility and robustness of our general framework are illustrated by reconstructing a polycrystalline microstructure from 2D EBSD micrographs and a binary metallic alloy from limited angle projections. Our framework can be also applied in the reconstructions based on small-angle x-ray scattering (SAXS) data and has ramifications in 4D materials science (e.g., charactering structural evolution over time).


This paper presents a hybrid finite element — boundary element method for the steady state thermal analysis of energy installations. The coupling of the two techniques is presented: finite elements are used in a bounded region containing thermal sources while the complementary domain is treated with boundary elements. With such a combination the number of unknowns is reduced and an accurate prediction of temperature is obtained. As an example, the temperature rise is computed for the case of three power cables laid in a thermal backfill: the finite element method (FEM) is used for the cables and the backfill while the homogeneous soil is taken into account with the boundary element method (BEM).


Intelligent user interfaces, particularly in interactive group settings, can be based on system explanations that guide model building, application, and interpretation. Here we extend Silver's (1990, 1991) conceptualization of decisional guidance and the theory of breakpoints in group interaction to operationalize feedback and feedforward for a complex multicriteria modeling system operating within a group decision support system context. We outline a design approach for providing decisional guidance in GDSS and then test the feasibility of the design in a preliminary laboratory experiment. Findings show how decisional guidance that provides system explanations at breakpoints in group interaction can improve MCDM GDSS usability. Our findings support Dhaliwal and Benbasat's (1996) conjecture that system explanations can improve decisional outcomes due to improvement in user understanding of decision models. Further research on intelligent agents, particularly in interactive group settings, can build on the concepts of decisional guidance outlined in this paper.


centuries. Kinship relations were not merely important for Scandinavians of that epoch; it would be more exact to say that there were no relations outside of kinship. Perhaps there is some exaggeration in this assertion, but it should be emphasized that all relations between people were seen through the prism of kin. Any connection between two relatives is conditioned by the term of affinity which describes it. One might say that these designations help to establish the order of interpersonal relations. A kinship system may determine, or even create, some very complex connections by choosing some very exact or very general term of affinity to describe the relationship between


Altogether 615 epithets of lichens are reported for Arizona. After the list is reduced by removing synonyms and misidentifications, 474 taxa remain -432 species in 78 genera, 2 subspecies, 16 varieties, and 19 forms. The catalog is based on reports in 92 papers. Although there is no adequate lichen flora for the Southwest, the recently published catalogs for Colorado (Shushan & Anderson, 1969) and New Mexico (Egan, 1972a) and the following catalog for Arizona document the reported lichen flora for the southern Rocky Mountain region. The most extensive lichen studies for Arizona were published subsequent to 1950; these include Darrow's (1950) study of the corticolous lichens of southeastern Arizona, Weber's (1963) study of the lichens of the Chiricahua Mountains, Johnsen's (1965a) report on the lichens of Oak Creek Canyon and Wetmore's (1970) study of the Heppiaceae. Recently the senior author collected extensively across the state and added 84 species to the published reports (Nash, 1973b; Nash & Weber, 1974). The major collections of Arizonan lichens are located in the Arizona State University Herbarium and the University of Colorado Museum. The land which now comprises Arizona was acquired from Mexico by the Treaty of Guadalupe Hidalgo in 1848 and by the Gadsden Purchase in 1853. Initially the area was incorporated as part of the New Mexico Territory, but in 1863 it became a separate territory. In 1912 statehood was obtained. Arizona's approximate boundaries are meridians 31 and 37 degrees north latitude and 109 and 114 degrees longitude. The total area of this approximately rectangular state is 113,909 square miles. Physiographically Arizona is divided by the Mogollon Rim into the Colorado Plateau Province to the north and the Basin and Range Province to the south (Fenneman, 1931). The Colorado Plateau which lies between 5000 and 10,000 feet is generally composed of sedimentary sandstones; the Basin and Range Province is largely composed of rocks of volcanic origin. The highest point in the state is Humphrey's Peak at 12,670 feet; the lowest point is at the southwestern corner at 100 feet. Climatically Arizona is characterized by sharply contrasting seasons (Sellers, 1960). Precipitation occurs predominantly in winter and summer and drought characterizes spring and fall. Annual precipitation varies from less than 5 inches in the southwestern deserts to over 45 inches along the Mogollon Rim and in the White Mountains. Yearly fluctuations in temperature are up to 1000F and daily fluctuations frequently exceed


In this study, the collaboration between buyer and the famers in potato production was evaluated by using a multinomial Logistic regression model with MLE estimating. The data were collected by directly interviewing of 245 farmers at the Xuan Tho commune, Da Lat city and Don Duong district, Lam Dong province. Results of the research showed that a tight collaboration between the companies and farmers would increase in a higher productivity. The estimation showed that the probability of farmer which would and would not collaborate with buyer were 14.6% (Y2/Y1) and 63.0% (Y3/Y1). The factors affecting the probability of linkages between enterprises and farmers were enterprises and farmers were experience, farm, size, profit, policy supports and gender. The results also revealed that when price of potatoes increase, farmers would not comply with agreement.


1 Department of Biological Systems Engineering, Virginia Polytechnic Institute and State  University, 210-A Seitz Hall, Blacksburg, VA 24061, USA  2 Key Laboratory for Molecular Enzymology and Engineering of the Ministry of Education, Jilin  University, Changchun 130023, China  3 Institute for Critical Technology and Applied Science (ICTAS), Virginia Polytechnic Institute  and State University, Blacksburg, VA 24061, USA  4 DOE BioEnergy Science Center (BESC), Oak Ridge, TN 37831, USA


A printing method for printing one or more print tracks on the printed substrate, or the substrate, onto the print support according to a pre-material layer determined print profile by each of the printing means in the printing step comprises at least two printing steps It is deposited. First in the printing phase of each of the second or subsequent printing step, the material layers respectively deposited at least in part on said material layer is printed in the preceding printing method comprising, a printed material layers each of at least the same as before the print zone on or such region and having the same or different print profiles with respect to the material layer at least in the lower part to achieve a different contact areas, the material deposited in each of the print step is the same as that deposited on at least one print of the underlying printed material or it is different.


Female teachers in colleges and universities,as a special group of intellectuals in China,their sports consumption reflects not only their knowledge of the physical education and health,but engage in physical exercise and the effect of physical health conditions,to a certain extent also affects the quality and effectiveness of their teaching.Female teachers ' ability to access to knowledge and new things are often much better than other professional women's groups,this leisure sports consumption behavior act as a strong role model.Which means the female teachers participating in recreational sports will affect the situation of students,and the attitudes and behavior of teacher sports consumer will influence consumer attitudes and behaviors of college students.Therefore,by leisure sports consumption behavior of female teachers in colleges and universities,this paper explores how to take reasonable leisure sports consumption of College female teachers optimizes the structure of consumption.It will be meaningful for their own development and the future development of students.


Toxoplasma gondii is a widespread parasitic infection, the activation of which is closely associated with the subsequent immune response. In HIV-infected patients, toxoplasmosis is one of the most common causes of brain damage, causing focal and cerebral symptoms, which can be difficult to diagnose, especially in cases where patients do not inform the doctor about HIV infection. The article presents clinical observations of patients with HIV-associated toxoplasmosis affecting the brain. Diagnostic difficulties arose due to the lack of reliable information about HIV infection in most patients. In the clinical picture, many patients had a multifocal brain lesion, which caused difficulties in recognizing the disease (metastases? encephalitis? Lymphoma?), and with an increase in hypertension-hypertension syndrome, an intracerebral tumor was assumed. To clarify the diagnosis, in case of detected volumetric brain lesions, surgical treatment was required, which was carried out in the volume of a stereotaxic biopsy in the compensated state of patients or emergency surgical intervention in decompensated patients to eliminate the dislocation syndrome.


Due to its important applications in data mining, many techniques have been developed for clustering. For today's real-world databases which typically have millions of items with many thousands of fields, resulting in datasets that range in size into terabytes, many traditional clustering techniques have more and more restricted capabilities and novel approaches that are computationally efficient have become more and more popular. In this paper, a new efficient approach to graph-theoretical clustering using a minimum spanning tree representation of a dataset is proposed which consists of two-phases. In the first phase, we modify the standard Prim's algorithm in such a way that an efficient construction of such a tree can be realized based on k-nearest neighbor search mechanisms, during which a new edge weight is defined to maximize the intra-cluster similarity and minimize the inter-cluster similarity of the data set. In the second phase, based on the intuition that the data points are closer in the same cluster than in different clusters, the longest edges in the minimum spanning tree obtained from the first phase are removed to form clusters as the standard minimum spanning tree-based clustering algorithms do. Experiments on synthetic as well as real data sets have been conducted to show that our proposed approach works well with respect to the state-of-the-art methods.


AIM
The aim of this article is to investigate the contemporary teaching of the management of defective direct resin composite restorations in dental schools in Japan.

METHODS
A questionnaire relating to the teaching of the management of defective resin composite restorations was developed and e-mailed to 29 dental schools in Japan in 2010.

RESULTS
Completed responses were received from 19 of the 29 invited schools (response rate = 66%). Eighteen schools (95%) report that they included the teaching of repair of direct defective resin composite restorations in their dental school programs. Thirteen schools reported that they included both clinical and didactic instruction on the repair of direct resin composite restorations. Fourteen schools did not teach any mechanical roughening of the exposed resin composite restoration surface before undertaking a repair. The most commonly reported treatment was acid etching with phosphoric acid (12 schools). The most commonly taught material for completing repairs was a flowable resin composite (16 schools).

CONCLUSION
The teaching of repair of defective resin composite restorations is well established within many Japanese dental schools, to a greater extent than in some other regions of the world. The impact of this teaching on subsequent clinical practices in Japan should be investigated. Furthermore, it is concluded that there is a need for much stronger leadership in operative and conservative dentistry, ideally at the global level, to resolve differences in key aspects of operative procedures such as repairs.


Copy photo of T&P train #34. There are two children standing beside the train looking at it. Written below the image are "Edgewood, Texas 1893" and "R. H. Carlson."


An attempt to model the "brush" flow, studied experimentally by Tachie et al. [Phys. Fluids 16, 445 (2004)], by means of slender-body theory revealed that a successful truncation procedure requires that a few orthogonal functions be sufficient to describe the singularity distributions. In previous applications, this was easily achieved. However, when walls and/or other slender bodies are in close proximity, a large number of basis functions are likely to be needed and a loss of diagonal dominance, indeed the eventual appearance of negative diagonal coefficients, precludes a successful truncation of the infinite system of linear equations. It was also noticed, but after the proofs had been checked, that a sign error, eradicating the above difficulty, had been made in the falling needle viscometer presentation [A. M. J. Davis and H. Brenner, Phys. Fluids 13, 3086 (2001)]. Fortunately, in that flow the bounding cylinder wall is sufficiently distant from the thin needle for a convergent truncation to be quick...


Objective To define the effects of high blo od pressure upon coronary flow reserve (CFR) measured by myocardial contrast echocardiography (MCE). Methods Studies were performed in 9 closed chest swine. Low-energy, real-time MCE was performed with commercial instruments in short axis view at papillary muscle level while infusing BR1 (Sonovue, Bracco) at 0.5 ml/min. High-energy FLASH frames destroyed bubbles every 15 cardiac cycles, and resultant time-intensity curves derived from these sequences were fitted to an exponential function as y = A(1-e -bt )+c from which the rate of signal rise (b) was obtained. CFR was calculated as the ratio of b values prior to and after adenosine infusion, and was obtained before and after increasing blood presure with vein infusion phenylephrine. CFR was independently determined by fluorescent microspheres.Results Phenylephrine increased the mean blood presure from 129/107 mm Hg(1 mm Hg=0.133 kPa) to 196/153 mm Hg (P 0.001 ) and changed heart rate from 114 beats/min to 124 beats/min (P 0.05 ). Adenosine produced a similar increase of CFR: 2.5 vs 3.1 for MCE and microspheres respectively. Blood presure elevation post phenylephrine increased resting and decreased post adenosine values of b ( 0.7 and 0.9 respectively) with a marked reduction in CFR ( 1.5 , P 0.05 ). CFR was also decreased as measured by microspheres ( 1.8 ). Conclusions Phenylepherine induced hypertension reduces quantitative parameters of CFR, derived from destroy/refill sequences by MCE.


A series-fed linear substrate-integrated dielectric resonator antenna array (SIDRAA) is presented for millimeter-wave applications, in which the substrate-integrated dielectric resonator antenna (SIDRA) elements and the feeding structure can be codesigned and fabricated using the same planar process. A prototype 4 × 1 SIDRAA is designed at Ka-band and fabricated with a two-layer printed circuit board (PCB) technology. Four SIDRAs are implemented in the Rogers RT6010 substrate using the perforation technique and fed by a compact substrate-integrated waveguide (SIW) through four longitudinal coupling slots within the Rogers RT5880 substrate. The return loss, radiation patterns, and antenna gain were experimentally studied, and good agreement between the measured and simulated results is observed. The SIDRAA example provides a bandwidth of about 10% around 34.5 GHz for 10 dB return loss and stable broadside radiation patterns with the peak gain of 10.5–11.5 dBi across the band.


We present the problem of categorizing web services according to a shallow ontology for presentation on a specialist portal, using their WSDL and associated textual documents found by a crawler. We treat this as a text classification problem and apply first information extraction (IE) techniques (voting using keywords weight according to their context), then machine learning (ML), and finally a combined approach in which ML has priority over weighted keywords, but the latter can still make up categorizations for services for which ML does not produce enough. We evaluate the techniques (using data manually annotated through the portal, which we also use as the training data for ML) according to standard IE measures for flat categorization as well as the Balanced Distance Metric (more suitable for ontological classification) and compare them with related work in web service categorization. The ML and combined categorization results are good and the system is designed to take users' contributions through the portal's Web 2.0 features as additional training data.


We present a gate-voltage tunable transmon qubit (gatemon) based on planar InAs nanowires that are selectively grown on a high resistivity silicon substrate using III-V buffer layers. We show that low loss superconducting resonators with an internal quality of $2\times 10^5$ can readily be realized using these substrates after the removal of buffer layers. We demonstrate coherent control and readout of a gatemon device with a relaxation time, $T_{1}\approx 700\,\mathrm{ns}$, and dephasing times, $T_2^{\ast}\approx 20\,\mathrm{ns}$ and $T_{\mathrm{2,echo}} \approx 1.3\,\mathrm{\mu s}$. Further, we infer a high junction transparency of $0.4 - 0.9$ from an analysis of the qubit anharmonicity.


The power loss of the machine-side converter (MSC) seriously affects the power generation efficiency of low-wind-speed maglev vertical-axis wind turbines with PMSG. In view of this, this paper proposes a direct torque control strategy with SVPWM modulation (SVM-DTC) based on BP neural network (BPNN). The inner loop is the electromagnetic torque tracking controller, in which, BPNN is trained off-line to appr-oximate the curve between stator flux reference value and electromagnetic torque to realize variable flux reference value control, so that the d-axis stator current can be controlled to keep zero. The BP-PID controller is designed as the outer loop controller to realize MPPT. The simulation results show that the proposed control strategy can reduce the power loss of MSC, improve the efficiency of the PMSG, and reduce the overshoot of the electromagnetic torque and speed of PMSG.


OBJECTIVE
The challenge of diagnosing Cushing's syndrome (CS) calls for high precision biochemical screening. This study aimed to establish robust reference intervals for, and compare the diagnostic accuracy of, salivary cortisol and cortisone in late night samples and after a low-dose (1 mg) dexamethasone suppression test (DST).

DESIGN AND METHODS
Saliva samples were collected at 08:00 and 23:00, and at 08:00, after a DST, from 22 patients with CS and from 155 adult reference subjects. We also collected samples at 20:00 and 22:00 from 78 of the reference subjects. Salivary cortisol and cortisone were analysed with liquid chromatography-tandem mass spectrometry. The reference intervals were calculated as the 2.5th and 97.5th percentiles of the reference population measurements. Diagnostic accuracies of different tests were compared, based on areas under the receiver operating characteristic curves.

RESULTS
The upper reference limits of salivary cortisol and cortisone at 23:00 were 3.6 nmol/L and 13.5 nmol/L, respectively. Using these reference limits, CS was detected with a sensitivity (95% confidence interval) of 90% (70-99%) and specificity of 96% (91-98%) for cortisol, and a 100% (84-100%) sensitivity and 95% (90-98%) specificity for cortisone. After DST, cortisol and cortisone upper reference limits were 0.79 nmol/L and 3.5 nmol/L, respectively. CS was detected with 95% (75-100%) sensitivity and 96% (92-99%) specificity with cortisol, and 100% (83-100%) sensitivity and 94% (89-97%) specificity with cortisone. No differences in salivary cortisol or cortisone levels were found between samples collected at 22:00 and 23:00.

CONCLUSION
Salivary cortisol and cortisone in late-night samples and after DST showed high accuracy for diagnosing CS, salivary cortisone being slightly, but significantly better.


It has been clarified that abdominal visceral fat accumulation is closely associated to the lifestyle disease and metabolic syndrome. The gold standard in medical fields is visceral fat area measured by an X-ray computer tomography (CT) scan or magnetic resonance imaging. However, their measurements are high invasive and high cost; especially a CT scan causes X-ray exposure. They are the reasons why medical fields need an instrument for viscera fat measurement with low invasive, ease of use, and low cost. The article proposes a simple and practical method of visceral fat estimation by employing bioelectrical impedance analysis and causal analysis. In the method, abdominal shape and dual impedances of abdominal surface and body total are measured to estimate a visceral fat area based on the cause-effect structure. The structure is designed according to the nature of abdominal body composition to be fine-tuned by statistical analysis. The experiments were conducted to investigate the proposed model. 180 subjects were hired to be measured by both a CT scan and the proposed method. The acquired model explained the measurement principle well and the correlation coefficient is 0.88 with the CT scan measurements.


Objective To establish new method to classify rhesus monkey immunogenetics homogeneity using microsatellite genetic markers.Methods According to the known Chinese and India rhesus monkey's microsatellite genetic markers and the specific major histocompatibility complex molecular(MHC) gene linked microsatellite genetic markers,52 rhesus monkey were classified by the microsatellite genetic markers and genetics homogeneity.Results The rhesus monkeys were divided into three groups: India,China and unknown geographical origin.Based on the microsatellite genetic markers closed to the MHC gene,monkeys were classified into several groups by the same MHC homogeneity.Conclusion This method will facilitate the establishment of rhesus monkey to participate in the experimental groups,as well as providing management for the breeding.


habits before, but for the last 12 or 13 years, had left off drinking, as well as excessive sexual indulgence. The commencement of tubercular leprosy was very insidious. The eruptions over his body began to appear about 5 years ago. At first they were mistaken for syphilitic eruptions, but since 2 years and a half the characteristic appearances of tubercular leprosy have been so marked that his own


The trajectory tracking control problem of nonholonomic mobile robots with parameter uncertainties has been analyzed. The kinematics and dynamical models of mobile robots are taken into account, the control rule based on the kinematics model is taken as desired virtual control, and the adaptive sliding mode controller is designed, as the controller take into account both kinematics and dynamical model, the robot can not only track trajectory smoothly, but also be robust to parameter uncertainties. Based on Lyapunov theory, the system is stable. Finally, simulations are performed on the system with parameter uncertainties, and the results show that the proposed controller can track desired trajectory effectively.


With a brief description about external structure,the internal composition and working principle of Power Drive Archer,PD Archer is compared with mud motor and other drilling tools in terms of safety,timeliness about215.9mm borehole in SZ36-1Oilfield.With study on parameter configuration,wellbore trajectory optimization,bits selection successfully applied PD Archer in SZ36-1Oilfield and solved the problem guiding the drilling of unconsolidated sandstone formations.This will give an experience reference for other parts.


The susceptibility of pitting corrosion of 0Cr18Ni9Ti stainless steel under different heat treatment conditions was investigated by means of electrochemical technique. The results show that homogeneous Structure produced by solid solution treatment has excellent resistance to potting corrosion while the structure produced by sensibilizing is most susceptible to pitting corrosion.Furthermore,stabilizing is unfavourable to resistance to pitting corrosion of the steel,although intercrystalline corrosion in the steel is restrained by it.


Impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) represent intermediate states between normal fasting glucose (NFG) or normal glucose tolerance (NGT), respectively, and diabetes (1). The regulation of fasting and glucose concentrations after an oral glucose load is dependent on different physiological mechanisms (2), and current evidence suggests that IFG and IGT have different pathophysiologies (3,4). Measurement of fasting plasma glucose (FPG) is the most frequently used screening test for diabetes. However, the oral glucose tolerance test (OGTT) might be a preferable test because FPG underestimates the severity of glucose intolerance (5,6) and because IFG and IGT define two distinct populations with only partial overlap (5,7,8). The present study was undertaken to compare insulin sensitivity and insulin secretion profiles associated with different stages of hyperglycemia as assessed by FPG only or by FPG and 2-h plasma glucose during an OGTT.

We analyzed data from 900 subjects without previously known diabetes who underwent an OGTT for diagnostic purposes at Fleury Institute, Sao Paulo, Brazil. A double-glycemic status was determined for each subject. A first set was based on FPG only as follows: NFG (FPG …


Herbal Medicines are a fast emerging trend in recent times, as they provide safer, effcective and economical treatment to patients. Azadirachta indica (neem) has been an integral part of health and oral care since times immemorial. It has shown to be an effective antimicrobial, antinflammatory and anticancer agent. In india it has been an indespensible part of oral care and is still a popular dental care agent in rural india. Incorporation of neem extract in oral health care products provides a natural solution to oro-dental problems and in maintaining oral health.


ABSTRACT The impact of a spill of about 375 tons of light fuel oil in the southern Baltic Sea has been studied for one year. The spill originated from the tanker Sefir which sank to a 50 meter depth about six nautical miles east of the island of Oland. The study showed that the oil formed droplets which were taken up by zooplankton. Up to 50 percent of the zooplankton died during the acute phase of the spill. The oil droplets were well dispersed and sedimented over large areas. In six weeks during the acute phase of the spill, about 20,500 kilograms of oil sedimented over a 10 square kilometer area around the wreck. This corresponds to about 5.5 percent of the total amount of lost oil. Bivalves showed some uptake of oil. The littoral fauna was reduced drastically over a 10 km stretch of the coast. Only 2 percent of the fauna survived. The biomass and number of species also dropped considerably. One year after the spill, a slight recovery could be observed. The severe impact in the littoral zone was caused...


In recent years,vocational education is faced with new and unprecedented challenges.Based on the analysis of these challenges,the paper summed up the reform and innovation of teaching content,teaching methods,and teaching means,examples of the new model of "The Concept Teaching based on APOS theory",and summarized the result of teaching practice.


Utilizing the Samples of Anonymized Records from the UK 2001 Census, this article presents an analysis of the differential experiences of Muslims in the British labour market as both minority- and majority-group ethnicities in Britain. Using multinomial modelling, this article examines the class distribution (using the NS-SEC scheme) given levels of education and gender. The analysis of ethnicity, age, gender, marital status and number of children in relation to employment suggests that there are no universal characterizations that can be founded on any of these independent variables. Although Pakistanis dominate the demographic profile they are not likely to suffer the greatest. Muslim Black Africans experience harsher conditions and it could be argued that there is an ethnic colour penalty that is greater than the ethnic religion penalty for Muslims. The forces of colour racism remain omnipotent, even when testing for the impact of religion on patterns of employment inequality.


In this study, modification of an amino polyether with resorcinol-aldehyde condensate was performed using four different aldehydes [formaldehyde, glutaraldehyde, butyraldehyde and 4-(N,N-dimethylamino)benzaldehyde] to give dispersants (1 – 5)  to be used as dispersing agents for solvent based inkjet inks. The prepared dispersing agents were characterized using FT-IR and GPC. The optical properties and stability efficiency of the ink formulated with the prepared dispersing agents were investigated. The dispersants (1-5) were evaluated for their efficiency   in comparison to commercial dispersing agents used in the market. Formulations of dispersants 4 and 5 showed excellent results in comparison to the commercial dispersing agents and have a good potential as effective dispersing agents for solvent based inkjet inks.


The purpose of this study was to analyze the previous color studies. A number of publications and journals were reviewed and analyzed carefully. The results of review and analysis were as follows: There were many different subjects in color studies and they were usually categorized into ten fundamental groups : color preferences, color image/symbo/association of ideas, emotion and colors, image making with colors, colors related with consumers` decision making, traditional colors, semantic color description, color plan of apparel merchandise, influential factors on colors, and color coordination preferences. In general, the color preference studies are conducted most actively, and they are followed by the studies of color image/symbol/association of ideas and traditional colors. In the previous studies on the color preferences, they provided sufficient amount of information on the preferred colors and the preferred apparel colors, however, they lacked in providing appropriate explanation on how these color preferences were related with colors in fashion. Also, there have been no thorough studies that questioned the reliability of measurement methods for obtaining color preference data. The authors also realized that it was extremely difficult to find any related publications on the studies that focus various influential variables on the disagreement between the preferred color and preferred apparel color. Thus, this study directed the future studies to solve the problem discussed above.


This article assesses the media treatment of the Catalan referendum on independence (October 2017) in the Québec context. By conducting a quantitative and deductive content analysis of articles published in the four major Québec newspapers, we analyse how Québec
 newspapers frames the conflict regarding their historical editorial position about the Québec independence project. In addition, we examine how the comparison between Québec and Catalonia fit into the media coverage. Our results confirm the dominant use of the conflict frame
 for media coverage of political issues. They also point out the importance of internal and institutional factors like the importance of press agencies or the presence of correspondent on the ground as features influencing frames. In terms of editorial position, data suggest that similar issues
 between two stateless nations do not automatically involve a similar media treatment. We suggest the concept of 'projection effect' to bring nuances to the 'mirror effect' proposed in the literature.


This article deals with legal regulations relating to European administrative cooperation which was implemented to polish administrative proceedings on 1st June 2017. This text applies to the Division VIIIa titled "European administrative cooperation", adopted to The Code of Administrative Proceedings. The authors of the treatise discuss the legal basis of European administrative cooperation in other countries of European Union and the reasons for incorporation new regulation to polish administrative proceedings. Authors of the article also resolve results of ReNEUAL Model Rules on EU Administrative Procedure project in the part referring to European administrative cooperation, which was the model for the Polish legislator. Authors also analyze the articles of The Code of Administrative Proceedings concerning European administrative cooperation and emphasize the interpretative problems which may occur in the law application process. In summary, authors discuss the reasons for which legal regulations concern European administrative cooperation may be used occasionally.


Thesuper-flexible wires, whichcanwithstand significant stretch aswellasbend,aresuccessfully developed byusing theconductive adhesive containing Agparticles dispersed inasilicone-based binder. After curing under suitable conditions, theelectrical conduction intheadhesive wasdetectable until theelongation reached to 100-180 %. Furthermore, theelectric resistance wasalmost recovered after removing tensile stress. Thiswiring technology wasapplied forfabricating aprototype sensor sheet forartificial skin applications of robots andrelated equipments. Thepiezoelectric films composed ;of poly(vinylidene fluoride) wereassembled on a silicone substrate by using thesilicone-based conductive adhesive inorder tofabricate thesensor sheet. Theinformation related topressure distribution was monitored successfully whenwe toughed thesensor sheet.


This paper deals with two new species and two male supplements of the genus Cheiracanthium from China.All type specimens are deposited in Dept.Biol.Hunan Normal University.Measurements are in millimeters.The scale lines equal to 0 10. Cheiracanthium ningmingensis sp.nov. (Figs.1 3) Holotype ♂,Ningming County(22 1°N,107 0°E),Guangxi Province,May 16,1997,leg.ZHANG Yong Jing. Male.Total length 8 28;carapace 3 36×2 78;abdomen 4 92×1 78.Body yellowish brown.Chelicera with 3 promarginal and 2 retromarginal teeth.Leg formula:1,4,2,3. This new species is very similar to Cheiracanthium japonicum Bsenberg et Strand,1906(Paik,1990:5 7,figs.1 13),but differs from the latte by:1)tibial apophysis of the new species forked at its distal end and faced to the inner side,but that of the latter didnt fork and faced to the outer;2)the retromarginal protuberance(rp) of cymbium is very distinct and situated near the anterior portion of the cymbiumm,while that of the latter not distinct and near the middle of cymbium. Famale:unknown. Cheiracanthium simaoensis sp.nov. (Figs.4 7) Holotype ♂,paratypes 1♂,2♀♀,Simao County(22 4°N,100 4°E),Yunnan Province,July 25,1981,leg.WANG Jia Fu. Male.Total length 8 76 9 15.Holotype measured.Total length 9 15;carapace 3 58×2 91;abdomen 5 57×2 16. Female.Total length 9 26 10 46.A specimen of total length 10 14.Carapace 5 08×3 39;abdomen 5 06×3 18. Male.Carapace pale reddish brown.Abdomen dorsum white yellow.Chelicera with 3 promarginal and 2 retromarginal teeth.Leg formula:1,4,2,3. This new species is similar to Cheiracanthium submordax (Zhang et al .,1993:106,figs.1 4),but can be differed from the latter by:1)tibial apophysis of the former more slender and somewhat slightly waved,that of the latter shorter and straight;2)the anterior half portion of posterior protuberance of the cymbium extends transversely,then backwards.But that of the latter gradually curves towards back.So the angle between cymbium ang its protuberance of the former is larger than that of the latter. Female.The body coloration,eye arrangement,cheliceral teeth and legformula are as same as these of the male.Spermatheca stomach like,the connect duct or copulatory duct with 2 spirals,but the allied species.Cheiracanthium submordax with the spermatheca in inverted stomach like and the connect duct with 4 spirals. Cheiracanthium exquestitum Zhang et Zhu,1993 (Figs.8 11) Male.Total length 9 62;carapace 3 95×3 12;abdomen 5 66×2 21.Chelicera with 2 promarginal teeth and 1 retromarginal;leg formula 1,4,2,3.The tibial apophysis with a wide base,its terminal end curved and pointed.Cymbium apophysis curved,its distal end forked.The anterior portion of cymbium concaved dorsally;embolus slender,curved,its base initiated from the anterior portion of genital bulb near retromargin. Cheiracanthium fibrosum Zhang et al., 1994 (Figs.12 15) Male.Total length 5 26 6 52;carapace 2 58×1 81;abdomen 3 56×2 08.Chelicera with 3 promarginal and 2 retromarginal teeth.Leg formula:1,4,2,3.The tibial apophysis cone like,witha protuberance ectally,another slender rodlike apophysis on the portion of tibia behind tibial apophysis.Cymbium apophysis slender and cruved,its base initiaied from the median portion of genital bulb near retromargin.


An example calculation of reduction device's driven shaft design in the course of Mechanical Design Foundation was introduced.It applied SolidWorks to establish a 3D model,and imported ANSYS Workbench to run finite element static strength analysis,which made the design more simple and convenient compared with the original bending and twisting combination strength calculation.


In article, based on a wide theoretical material of foreign researches, the author gives the review of a current state of degree of a readiness of a question of corporate strategies of the international companies.


To the Editor: —I have read the March issue of theArchives, and I would like to correct one of the news items on page 413: "Vail Elected." Derrick Vail was not elected by the Congress but by the International Federation of Ophthalmological Societies which held a meeting in New Delhi at the same time as the Congress was held there. I admit the confusion is excusable, and here is the exact relationship between the International Congress of Ophthalmology, the International Federation of Ophthalmological Societies, and the International Council of Ophthalmology. The Federation has about 60 societies affiliated from all over the world. The Federation organizes every four years an International Congress, choosing its location and setting its date. From that time on a National Committee organizes the International Congress. The Federation also elects the members of the International Council of Ophthalmology which acts, from then on, as the executive


The article analyzes the system of budget administration bodies, and also examines the limits of competence of budget administration bodies that make up its architecture. The budget administration bodies that make up the federal, regional and local levels of budget administration bodies are considered.


With significant increase in interest in dementia and Alzheimer's disease, a form of dementia that deteriorates the brain as well as the memory along with other important mental functions, in which brain neuron connections begin to disintegrate and die. Memory loss and confusion being the main symptoms, physicians and scientists are yet to find a concrete cure for the same. However, different strategies and medications have been found to be helpful, especially if early detection is possible. The report shows the results and analysis of detecting Alzheimer's using machine learning models and compared them. The OASIS dataset has been applied to different machine learning models like SVM, Logistic Regression, K-Nearest Neighbors, Naive Bayes, Decision Tree, Random Forest, and Ensemble Learning. It has been run through these models before and after fine tuning. The best accuracy was found with Support Vector Machines after fine tuning. Another observation is that the inclusion of feature of CDR' i.e., Clinical Dementia Rating showed a spike in the evaluation metrics with the best accuracy being 97% achieved by Support Vector Model.


Experimental menggunakan media data matematika soal untuk mengukur berpikir kritis siswa. Analisis data the paired sample test, the normality and homogeneity of the data were tested. The results obtained data are normally distributed and homogeneous. The results showed that there was an effect of using YouTube online learning media on students' interest in learning and critical thinking skills. This is indicated by the significance value for learning interest of 0.017 which is less than 0.05 and the significance value of critical thinking 0.005 which is smaller than 0.05. Furthermore, the value of N-Gain is sought to determine the extent of the influence of YouTube media on interest in learning and critical thinking. The N-Gain value for students' interest in learning mathematics is 0.12 and critical thinking is 0.28. Both values are in the low category so that the influence of YouTube media on interest in learning and critical thinking is less effective. This is an open access article under the CC BY-SA license.


Abstract. Calcium fluoride and zinc sulfide crystals exhibit broad multispectral transparency and are used for a multitude of optical applications. However, they both belong to a soft brittle crystal category and are mechanically challenging to process. Thus, a fabrication protocol using a single-point diamond turning method was developed, which can yield surfaces with optical quality for these materials. By using a diamond turning tool with low waviness (≤100-nm waviness) and by using feed rates of 1 and 0.2  μm  /  rev, CaF2 and ZnS surfaces with surface roughness of 6 and 5 nm were manufactured, respectively. Design and fabrication of a miniature objective with 0.5 NA are also presented, which was developed for the ultrafast laser microsurgery application. The objective consists of CaF2 and ZnS lenses to withstand the high power from ultra-short laser pulses and to provide a tightly focused beam with 1.23  μm 1  /  e2 spot radius for laser ablation. Based on the spot size measurement of the objective, its performance was considered to be near diffraction limited.


Lego company created a set called Robotic Invention System as a kind of Mindstorm set. This system helps to understand the technology of both robot and programming language. It also improves creativeness by building and controlling the robot we make. This paper will introduce basic idea of controlling the RCX(Programmable Lego Block) in C language. Also, this paper will show different idea of teaching C language by using other types of robots.


Increasing electricity demand is accompanied by concerns about the avaiLability and price of fossil fueLs and about the environmentaL impacts of eLectric power generation. Emerging non-nuclear energy technoLogies and systems can offer severaL potentiaL advantages to compLement conventionaL sources of energy to meet future needs. The advantages of the aLternative technoLogies, however, must be baLanced against the inherent limitations associated with some of the technoLogies. The technoLogies using aLternative energy sources have been under active deveLopment for the past decade, and require continued technoLogy deveLopment to improve performance, economics, reliability, and environmentaL acceptability. The technoLogies closest to, or having reached, small-scaLe production status include small wind systems, dry-steam geothermaL, and biomass processes. Fuel cells, grid-connected photovoLtaics, soLar thermaL, water-dominated geothermaL, advanced coaL systems, and energy storage systems require more deveLopment before they can contribute effectiveLy. The American Nuclear Society recognizes that many renewabLe and emerging energy technoLogy systems can contribute to the overall reliability of the eLectric grid. That contribution is Limited, however, by the Location-specific nature of many sources and requires major technoLogicaL deveLopment.


In this paper, a novel concept designed of a multi-legged underwater manned seabed walking robot is presented. The robot will be used in both shallow water current (1–2 m/sec) and deep water up to 500 m. It is powered by an external electric power source through tether cable. It walks on the seabed with six legs, which makes it distinct from conventional screw-propelled underwater robots. It can walk calmly without making the water turbid. Two anterior arms act as manipulators. All leg joints and manipulators are controlled by Brushless Direct Current Motors. Motivation for this concept comes from soldier crab that walk mostly forward and has an egg-shaped body. It is operated by a pilot sitting in a pressurized cabin, and promptly control operations of the robot and manipulator. Preliminary design of the pressurized cabin, using an empirical formula, "ASME PVHO-1 2007" standard, and validation was carried out through ANSYS Workbench. Hydrodynamic forces acting on the robot body and legs are utilized to withstand the water current and external forces to adjust legs and body posture for stability. Buoyancy rules are employed to control its rising and diving motion. All key technologies employed in the development of the robot and their approaching methods are explained. It will provide a safe operation space for humans in underwater operations.


A 23×15" platform (PODOSCAN) containing 1024 transducers has been designed for analyzing pressure distribution beneath the foot during movement using a piezoelectric Polyvinylidene-Fluoride (PVDF) film. An electronic switch is coupled to each sensor and all the switches on the same row converge towards a charge amplifier. A control signal connects sensors on the same column to the amplifiers. This architecture reduces the external connections of a matrix from NxM+1 to N+M+l only. By utilizing this technique on a film integrated circuit, a flexible high resolution insole to be inserted in a shoe as well as a miniaturized device for tactile images collection in robotics may be realized.


Though the analysis of the actual demand of quality management in a shock absorber enterprise,the necessity of building visual quality management system based on MES was expound.Requirement of basic module and function and data of each module about this system were analysed in detail.Meanwhile,the function module of this system was designed with IDEF,such a move could pave the way for building the visual quality management system.


Humanistic and transpersonal psychologies have eclipsed a focus solely on pathology assessment and treatment to a broader focus on the human being's growth toward optimal functioning, often called self-actualization. Paradoxically, Maslow recognized that peak experiences often lead the self- actualizing individual to transcend the personal concerns of the very self that was being actualized. The ego moves away from focusing on its traits and toward a consolidation of identity. Qualities associated with higher stages of ego development are very similar to qualities associated with spiritual transformation: a consistent sense of presence, an authenticity, and a lightness or ease of being. Descriptions of people functioning at an optimal level include increasing flexibility, conceptual complexity, and tolerance for ambiguity; recognition and acceptance of internal contradictions; a broader and more complex understanding of the self, others, and the self in relation to others; internalized self-control and emotional self-regulation; transcendence of ego boundaries; transparency; "postambivalence" i.e., total wholehearted and unconflicted love, acceptance, and self-expression. We examine three realms of development: ego growth, soul embodiment, and spirit realization succinctly stated by Teilhard de Chardin: "First, be. Secondly, love. Finally, worship".


When patients come first, all else will follow. In abundance. Weston Welker, MD, knows that. He watches it happen every day in his Southside Family Practice in Huntsville, Ala.


There is no document of civilization, in Walter Benjamin's unsettling phrase, which is at the same time not a document of barbarism.1 Sadly, this is one of the odious but great truths about human history. The progress of civilization has co-existed with barbaric dehumanisation of the many. This duality, however, has always been a choice rather than a necessity. To take one recent example, India's dazzling economic turnaround is made possible on the cheap labour and exploitation of the suppressed majority. With people as intelligent, innovative and resourceful as those of India, the continuity of mass poverty is a choice, not a necessity. The continuance of socio-economic exclusion is the choice of India's ruling class which subconsciously or otherwise carries forward the brahmanic mindset of discrimination, while paying lip service to democratic values and ideals. To a great extent, the lack of an inclusive spirit, justice and compassion in contemporary India results from the old and new paradigms of caste and brahmanic exclusion. As the old oppressive ideas and practices constantly reinvent themselves in new forms to beat the heat from below, the people at large fail to see how caste, class, gender and religion-based inequalities are still being reproduced under the rubric of democracy.


Purpose We investigated the effects of cell therapy on myocardial perfusion recovery after primary percutaneous coronary intervention (PCI) treated acute myocardial infarction (AMI). Materials and methods In this HEBE trial substudy (IRB approved, trial registry number ISRCTN95796863), we assessed the effects of intracoronary infusion with bone marrow-derived mononuclear cells (BMMCs) or peripheral blood-derived mononuclear cells (PBMCs) on myocardial perfusion recovery, using cardiac magnetic resonance (MR) imaging after revascularization. In 152 PCI-treated AMI-patients, cardiac MR was performed after informed consent, before randomization to BMMCs, PBMCs or standard therapy (control), and was repeated after 4 months follow-up. Cardiac MR imaging consisted of cine imaging, rest first-pass perfusion and late gadolinium enhancement (LGE). Perfusion was evaluated semi-quantitatively from signal intensity-time curves by calculating the relative upslope (% signal intensity change). The relative upslope was calculated for the myocardial infarct (MI) core, adjacent border zone and remote myocardium. Perfusion differences between groups or between baseline and follow-up were assessed with Wilcoxon signed rank test or Mann-Whitney U-test. Results At baseline, median myocardial perfusion differed between MI core (6.0 [4.1-8.0]%), border zone (8.4 [6.4-10.2]%) and remote myocardium (12.2 [10.5-15.9]%; all pvalues <0.001), with equal distribution among treatment groups. At follow-up, these inter-regional differences persisted (all p-values <0.001). No difference in perfusion recovery was found between the three treatment groups for any region. Conclusion After revascularized STEMI, cell therapy does not augment the recovery of resting perfusion in either MI core or border zone.


The study of gender stereotypes is very relevant for linguistics, since they are fixed in the language and reflect social realities, namely ideas about femininity and masculinity in the framework of a specific language. To a greater extent, gender stereotypes are defined and updated by the media, which are a kind of window that reflects society and at the same time a powerful tool for shaping public opinion. Therefore, the choice of the magazine as a source of materials for the linguistic representation of gender stereotypes is evident. The author of the article attempts to analyze the language tools used for the linguistic representation of the gender stereotype of femininity in the weekly news magazine Paris Match. For this purpose, the author selected and reviewed Paris Match magazine publications about women over the past three years by the method of continuous sampling. All the gen-der-nominated units were divided into eight groups, each of which forms a specific female image (stereotype). The most numerous one is the group that defines a woman as a celebri-ty, an idol, a glamour beauty, and a fatal woman. The next group describes a giddy young girl, pretty and immature. The third group is represented by lexical units that nominate such qualities of a woman as independence, industriousness, and intelligence. The common fea-ture of the next group is a woman's mystery and her divinity. The traditional image of a woman-mother and a woman-housewife is represented in the fifth group. In the sixth group, the semantic criterion is weakness, unhappiness, and inaction. For the next group, the gen-eral conceptual basis is relations with a man. And the last group introduces a rebel woman who set herself against the


Effects of lectin from sea mustard Undaria pinnatifida on non-specific immunity in kuruma shrimp Penaeus japonicus weighing 6-7 g were studied by injection of lectin at a dose of 2.3 mg per individual 24,48,72,96,and 120 h after injection.The results showed that the shrimp with injection of lectin had higher activities of hemagglutination,phenoloxidase(PO),and superoxide dismutase(SOD),alkaline phosphatase(ALP) and lysozyme(LYS) in the serum than those in the control group from 24 to 120 h after injection.The maximum activities of the serum hemagglutination and PO were observed 24 h after injection,which was 8 times and 64 times higher than those in the control group,respectively.The peak activity of SOD,2.6 times higher than that in the control group,occurred 48 h after injection.The maximal activities of ALP and LYS appeared 72 h after injection,which were 2.6 times and 4.2 times higher than those in the control group,respectively.The maximal antimicrobial activity,higher than that in the control group,was observed 24 h after injection,which was 1.3 times higher than that in the control group.The phagocytosis rate and phagocytosis index of blood cell,higher than control group in 24-72 h and 120 h,reached maximum at 72 h,which were 1.2 times and 1.4 times higher than those in the control group,respectively,indicating that sea mustard lectin can enhance the non-specific immunity of the shrimp.


The Special Bar Quality family comprises a wide range of steel grades, mainly requested by the automotive, energy and engineering sectors, for applications where significant performances are required (eg. stresses, temperatures, working cycles, etc.). To meet these requirements it is necessary to reach a precise control of both the mechanical characteristics and metallurgy structures along the whole production chain. For semi-product with large dimensions, such as equivalent diameters around 300 mm, this is traditionally obtained through a manufacturing route which comprises the casting in ingots followed by reheating, forging and rolling. After 2010, new processes were investigated and technologies developed to replace the ingot route with a continuous casting followed by controlled high-reduction rolling. In these processes a seamless integration of CCM with rolling is implemented so to obtain the precise control of material flow, applied deformation and working temperatures. By using the proper combination of rolling diameter, speed and applied reduction, a very good control of the metallurgy structure across the whole section can be obtained, so to also remove the internal discontinuities ("voids") generated during the continuous casting. These processes, which can be defined "forging-like", are applicable to several grades also with large semi-product dimensions (300 mm and more). Besides, removing the ingot route means increased yield and productivity, which is very beneficial to the economical management of the plant. An example of this "forging-like" process is represented by the high-reduction blooming stand installed by Acciaierie Venete in the Padova-Camin mill. This article describes its main concepts as well as its technology and process features. Key-words: SBQ; rolling; forging; voids; metallurgy microstructure 1 Technology Primetals Technology Italy 2 R&D Primetals Technology Italy 3 Sales Primetals Technology Italy 54o Seminário de Laminação e Conformação Anais do Seminário de Laminação e Conformação ISSN 2594-5297 vol. 54, num. 1 (2017)


Successful presidents demonstrate a sustained concern for institutional renewal. Continuous and quality efforts at invigoration and renewal should occur with an approximately equal thrust for trustees, administrators, faculty, adjunct faculty, paraprofessionals, secretaries, custodians, and maintenance personnel. In addition, the external publics served by the college should receive continuous interaction with the institution. In many cases institutions have directed their renewal efforts primarily at faculty through staff development programs. Faculty are only one component of the spectrum to whom these efforts should be directed.


This study aims at developing animated movie series for children as learning media to boost Indonesian young learners' critical thinking. The product specification is as follows: (1) animated movie series help children practice their critical thinking using the designed patterns; (2) the content of the movie contains moral values for character building in Indonesian multicultural society; (3) the language exposure in the animated series is comprehensible for children, and (4) the development of the story is through naturalistic style. The design of this study is adapted from R2D2 (Recursive, Reflective, Design and Development) by Willis (1995). The result of this study is six animated movies which has been tried out for the designed participants


Single crystals of Sr_3Ga_2Ge_4O_(14) garnets doped with 15at.%, 8at.% and 2.5at.% Nd~(3+) were grown by modified Bridgman method. Nd~(3+)∶SGG crystal with a dimension of 26mm×15mm was obtained, and its optical absorption spectrum was measured. The characteristics absorption peak is located at 806nm and it broadens and shifts to short wave compared with that of Nd~(3+):YAG crystal. This is attributed to the statistical distribution of Ga~(3+) and Ge~(4+) cations in Sr_3Ga_2Ge_4O_(14) crystal and results in the improvement of pump efficiency and the decrease of pump threshold. It indicated that Nd~(3+): Sr_3Ga_2Ge_4O_(14) crystal is a promising laser crystal.


OBJECTIVE To understand the health risk behaviors of secondary students in Lucheng District and to provide evidence for the establishment of secondary students health education.METHOD An anonymous questionnaire survey was conducted among 465 students by stratified random cluster sampling.RESULTS Health risk behaviors were common among secondary students.In the survey of the past year,13.76% of the students had fighting once or more,8.39% of them often felt lonely,14.41% of them had thought about committing suicide,17.39% of them were unable to control their impulses to the net,22.80% of them had violation in biking,4.95% of them had obvious fat.1.72% of them had ever sexual behavior.In the investigation of the past 30 days,there were 4.52% and 31.61% of the students had smoked and drank respectively.During the survey of the last 7 days,13.76% and 15.27% of them who didn't do daily high or mediumintensity sports activities respectively,and 50.43% of them ate western-style fast food.CONCLUSION The health risk behaviors among secondary students aren't ignorable.Effective preventive measures should be further strengthened so as to prevent or reduce the risk behaviors to health of adolescents.


The selection of monitoring sites in emergency monitoring of sudden marine pollution accidents is directly related to the reliability of monitoring results. Firstly, this paper creatively puts forward the concept and calculation model of the effectiveness of monitoring sites, which is described in terms of the pollutant concentration and the sensitivity of the region. Then, taking the maximum of the effectiveness of monitoring sites and the minimum of the number of monitoring sites as the objective function, and considering the constraints such as monitoring resource capacity and monitoring risk, a multi-objective optimization model is constructed, and the Pareto frontier is obtained by using NSGA-II algorithm, after which the most satisfactory scheme is selected by the weighted TOPSIS method. Finally, an example is given to illustrate the feasibility of the model, which can quickly give a scientific, reasonable, economical and efficient scheme for the layout of monitoring sites and provide decision support for marine emergency monitoring.


In this paper, we propose a novel peer-to-peer based information diffusion scheme for mobile ad hoc networks. Due to mobility and bandwidth constraints, it is not always possible to share a complete content within a single transmission from one mobile device to another. To address this problem, we introduce segmentation of contents into smaller pieces for efficient information exchange. In mobile ad hoc networks, since it is impossible for a node to know the content of every other node in the network, we propose a Spatial-Popularity based Information Diffusion (SPID) scheme that determines urgency of dissemination of content according to the necessity in a neighborhood. Substantially, the segmentation policy and popularity based information dissemination reduce content acquiring time for each peer. Extensive simulation studies demonstrate that the proposed scheme is efficient in data distribution in mobile ad hoc networks, and prove superiority to other existing methods.


Global capitalist economic restructuring is affecting the working lives of American women. This article examines the growth of women's employment opportunities and the quality of their jobs as a consequence of the restructuring of employment, increasing flexibility of work, changing skill demands, and attempts to reduce hierarchy and increase workers' participation in the work process. The outlook for the 1990s is negative for many women, yet positive for a few if trends continue in their present direction.


What makes a dictionary exploitable in Natural Language Processing (NLP)? We examine two requirements: readability of information and general architecture, and we focus on the human tasks involving NLP dictionaries: construction, update, check, correction. We exemplify our points with real cases from projects of morpho-syntactic or syntactic-semantic dictionaries.


The article lists the unusual shipments in air transport.Over 2% of the annual cargo air transportation are the unusualshipments. Good co-ordination of the reception and deliveryprocesses of unusual shipments is one of the importantfactors in providing good and fast service knowing the basicregulations in air traffic.


Zhou Bangyan was an important poet in Song Dynasty.The artistic features of his poems are vigorousness and elegance.Vigorouness means that he expressed gloomy sentiment in his poems,which reappear the spiritual world and depressed affection of scholars since Song Dynasty and that his poems are alundant in various artistic means and attach importance on the arrangement of images and on angles and layers of expression to realize the vigorousness of the poems.Elegance refers to the implicity and grace of the poems,the third element--narration with elements of dialogues and means of montage,allusions which appear in every line and harmony of temperament as well.


A three-dimensional morphodynamic model of sequential beach changes Is presented. The model Is based on variations in breaker wave power generating a predictable sequence of beach conditions. The spectrum of beach conditions from fully eroded-dissipatlve to fully accreted reflective is characterised by ten beach-stages. Using the breaker wave power to beach-stage relationship the model Is applied to explain temporal, spatial and global variations In beach morphodynamlcs.


Multi-junction solar cells combining III–V top cells with a Si bottom cell offer the potential to increase the solar energy conversion efficiency beyond the 30% single-junction theoretical limit. In this work, monolithic 2-terminal triple junction (3J) GaInP/AlGaAs/Si solar cells of VOC around 2.9V are produced by means of direct wafer bonding between GaAs and Si materials, which allows for a permanent, electrically conductive and optically transparent interface [1]. However, a large current mismatch between top III-V and bottom Si subcells severely limits the 3J performance (Fig. 1a). Varying Si subcell design and fabrication processes, we study the influence of the Si bottom subcell parameters on the 3J device performance. GaInP/AlGaAs cells are grown in inverted configuration by MOVPE on 4" GaAs substrates at Fraunhofer ISE and then reported on n-on-p homo-junction Si cells by surface activated bonding. The Si solar cells are produced using 14-22 ohm.cm CZ or 1-5 ohm.cm FZ 4" (100) 525 μm-thick Si substrates. Using high minority carrier lifetime FZ Si substrates is expected to improve EQE at long wavelength in comparison to CZ substrates [2]. The formation of c-Si bottom cell with an optimum emitter, in terms of doping and thickness, at the front surface is critical to Si cell performance. Target doping profiles, which are dependent on III-V/Si interface recombination velocity [3], are defined using PC1D simulations. Doping is realized by diffusion or ion implantation processes (beam line or immersion plasma followed by thermal activation), allowing for doping profile tuning as shown in Fig. 1b. Back surface recombination is limited using an appropriate rear-side passivation [4]. In this study, the Si cells are produced on single-side polished substrates with Back Surface Field (BSF) and full sheet back metal contacts as well as on double-side polished substrates with BSF and PERC-like passivation using dielectric layers with point metal contacts. The III-V on Si layers are then processed into solar cells by: removal of GaAs substrate, mesa etching, deposition of front and back metal contacts, and a dual layer SiNx/SiO2 anti-reflective coating (ARC).


Power consumption management in computing systems is gaining an increasing attention due to its environmental and economic impact. On one side, it has been estimated that CO2 emissions of U.S. data centers during 2010 were on par with those of an entire country like Argentina. On the other side, the cost of the energy required to keep the system running is quickly going to overcome the cost of the physical system itself. Despite the improvements in the hardware technology, a proper management of the applications running on top of that hardware is still of paramount importance, since estimations show that the power demand of datacenter will rapidly grow 10% 12% per year. Power consumption is an important issue even on smaller devices. For example, on mobile devices, an efficient power management leads to a longer battery life and to a better user experience. Moreover, a better battery management would enable the diffusion of more complex and richer applications. In this thesis, we focus on scenarios where the user wants to express specific Quality of Service (QoS) requirements on his application, regarding performance and power consumption. Requirements can be enforced by using self-adaptive algorithms, to dynamically and automatically adapt the number of resources allocated to the application (i.e., its configuration). To select a proper configuration, most existing approaches rely either on heuristics or on machine learning models. While heuristics may work fine in general, they are usually less accurate than machine learning solutions. On the other hand, despite being more accurate than heuristics, machine learning techniques typically require extensive training phases to be performed offline, before the application starts its execution. Moreover, machine learning techniques may not be able to find a suitable configuration for applications with characteristics different from those of the applications used to train the models. In this thesis we try to close the gap between these two approaches, by proposing an online learning algorithm which, like the heuristics, will not rely on any training phase to be performed offline and, at the same time, can achieve the same accuracy of complex offline machine learning approaches. Since a


Abdominal distension and aches are commonly seen symtoms in infants when they are fed improperly,then suffer from indigestion.Application of radish seed on the umbilicus is very effective for the treatment.


Abstract The high-pressure behavior of the two Al2SiO5 polymorphs sillimanite and kyanite was investigated up to 46 and 53 GPa, respectively, using a diamond-anvil cell and powder X-ray synchrotron diffraction. The bulk moduli of sillimanite and kyanite obtained from a fit to a second-order Birch-Murnaghan equation of state are B0 = 176(11) GPa and B0 = 190(3) GPa at fixed B′ = 4, respectively. The samples were laser annealed several times at high pressures. After laser annealing at 46 GPa, sillimanite was decomposed into its oxide components corundum (Al2O3) and stishovite (SiO2). The high-pressure behavior of kyanite, however, is more complicated. Up to 20 GPa, kyanite remains stable. At 30 GPa a new high-pressure form is observed, which seems to be structurally related to kyanite. After laser heating, it partly decomposed into corundum and stishovite. However, when laser heating at much higher pressures of 47 to 53 GPa, the new phase remains stable.


CHARACTERIZATION OF BIFIDOBACTERIA ISOLATED FROM HONEYBEE BY RANDOM DNA AMPLIFICATION M. Grmanova, E. Vlokova, V. Rada, J. Flesar Department of Microbiology, Nutrition and Dietetics, Czech University of Life Sciences Prague, Prague, Czech Republic Background: Several methods of DNA analysis have been used to compare and identify bifidobacteria isolated from food, gastrointestinal tract of humans and animals. PCR-RAPD has been found to be useful in differentiating between closely related bacteria.


The shelf life of the sugarcane juice ('Mandya' variety Co 62175), packed in high‐density polyethylene‐based nanocomposite films, was investigated for 60 days with 15 different combinations and thickness of nanoclay and compatibilizer. To assess the product's stability, physicochemical, microbiological and sensory tests were performed at 15‐day intervals. The bio‐chemical quality attributes, namely, total sugars, pH, total soluble solids and overall acceptability scores, were found to decline with regard to storage period under ambient conditions. The pH, total soluble solids (TSS) and total sugar content varied from 5.18–4.83, 19.20–18.10°Brix and 18.21–17.54 g/100, respectively. The microbial quality of the stored juice was found to be depended on the quantity of compatibilizer, nanoclay and thickness of the packaging film. Among the developed nanocomposite high‐density polyethylene (HDPE) films, material E (with 2% and 5% of nanoclay and compatibilizer, with 100‐μm thickness) and material G (with 6% and 5% of nanoclay and compatibilizer, with 100‐μm thickness) showed better physiochemical stability with zero microbial population in the sugarcane juice.


Modified-Plain-Ridge-Ditch techniques (Tech 1: pyrite layer at top, jarosite layer at middle and top soil at the bottom of ridge; Tech 2: top soil at top, pyrite at middle and jarosite layer at the bottom of ridge) were used under field condition for the reclamation and improvement of the pre-leached Cheringa acid sulfate soil manipulated by basic slag (BS20 and BS30: basic slag 20 and 30 t ha) and aggregate size (A20 and A30: aggregate sizes of soil less than 20 and 20-30 mm) treatments. The initial soil had very low pH (3.4), high ECe (1.6 S m) and pyrite content (76 g kg). Magnesium content (water soluble + exchangeable = 5.38 c mol kg) of the soil was about 3 fold than that of Ca (1.71 c mol kg), and Al content (9.22 c mol kg) was highly toxic level. The preand post harvested soil data revealed that the properties of the soil was strongly (p≤0.05) influenced by the different treatments. The average soil data of all the treatments at post harvesting of rice cultivars were increased by 1.5 units for soil pH(dry) and 12 to 463% for the contents of N, P, Ca and Mg, while decreased the concentrations of Fe, Al, Na, Cl and SO4 by 27 to 93% compared with the initial soil. The maximum growth and yield of rice grain (5.4 t ha) were attained by the local cultivar Pizam compared with the high yielding variety BR 14 (5.1 t ha) by the A20BS30 treatment in the ridges of the Tech 2. The lowest grain yields of 0.03 (BR 14) and 0.07 (Pizam) t ha were recorded for the control plots (where no amendment was applied). The other treatments also resulted in a significant (p≤0.05) improved performance on plant production compared with the control.


Technology has been growing rapidly to help humans living their everyday life. Human, as the user interacts through an interface called user interface (UI), and the experience that the users are having is called user experience (UX). UI and UX are inseparable as a good user interface will result in a better user experience. Portal Unand is a web-based app that has all academic information for students. An initial survey was conducted to find out student's thoughts on Portal Unand. Students have complaints towards Portal Unand due to its unresponsiveness, old-fashioned design, important features weren't highlighted, etc. Hence, it reduced user experience in using Portal Unand. In this study, the redesign was done by using the design thinking. The study started from empathizing with the users until testing the prototype to the users by conducting usability testing. Usability testing was conducted by using Maze and System Usability Scale (SUS). The score of usability testing was 84 which fell into the high range. The SUS score was 83.33 which fell into grade A and acceptable category. As the new prototype managed to fulfill users' needs and met users' expectations, the prototype was usable and ready to be developed.


In recent years, there have been many examples of attackers exploiting vulnerabilities in the domain name system to infiltrate and steal information and assets. There have been breakthroughs in the research on malicious domain name detection using artificial intelligence. However, there is no specific plan for the research on knowledge graph and malicious domain name detection. Therefore, we innovatively combine the two and propose a malicious domain name detection model based on knowledge graph. We first combined the DNS flow graph with the DNS domain name hierarchy graph by means of rule alignment, and established a new DNS information knowledge graph. Second, we simultaneously complete the vectorization of entities and attributes in a joint learning manner as the input of the detection module. Finally, we combine DNS information, knowledge graph and neural network, and convert the DNS information into entities and attributes in the knowledge graph based on the knowledge graph. Experiments show that the malicious domain name detection model proposed in this paper has excellent performance and good generalization ability.


In this paper, we have examined the impact of tax cut on foreign direct investment (FDI) in Southeast Asian countries as a response to the debatable issue of the relationship between tax cut policy and FDI. We use corruption perception index and government effectiveness as the control variable, as well as other economic and demographic variables such as GDP growth, tax revenue, inflation, unemployment and population growth. Using Fixed Effect Model on panel data for a period of 1997-2016 adopted from World Bank, UNCTAD, and various websites, our findings suggest that in Southeast Asian countries, even though corporate tax cut policy gives a negative effect on FDI, this tax cut policy is not the main factor that induce investors. It is trade openness and GDP growth which become the reasons for investors to invest in this region. Moreover, the effect of government performance has played pivotal role in attracting FDI inflows.


In their paper [Doulliez, P. J., M. R. Rao. 1971. Maximal flow in a multi-terminal network with any one are subject to failure. Management Sci.18 1, September 48--58.], Doulliez and Rao present algorithms that solve two flow problems for a single source, multi-terminal network. The first problem that they solve is the construction of a flow that maximizes the value of t, where the demand at each sink is a nondecreasing, linear function of t. Given such a flow, the second problem that they solve is the construction of a flow that maximizes the value of t when the capacity of an arc is reduced. This paper supplies a finiteness proof for the first algorithm and sketches a finiteness proof for the second algorithm. The proofs are based on the well-known fact that a network possesses only a finite number of different spanning trees.


Richard Bavier is a policy analyst at the Office of Management and Budget. The views expressed are the author's personal views and do not represent the views of OMB or the Administration. E-mail: Richard_B._Bavier @omb.eop.gov In response to the rapid decline in welfare caseloads before and after enactment of the Personal Responsibility and Work Opportunity Reconciliation Act of 1996 (PRWO or simply welfare reform), considerable resources have been devoted to "leavers studies." These tracked the employment and income of families that have left the welfare rolls–the State programs funded by the Temporary Assistance for Needy Familes (TANF) block grant that replaced Aid to Families with Dependent Children (AFDC). Leavers studies have been conducted by a variety of researchers in many States. By design, leavers studies could not provide any information about families that may have been deterred or diverted from coming onto the welfare rolls by the new welfare reform policies. In addition, the leavers studies were mostly limited to measuring the personal income of former welfare recipients, missing possible economic benefits from those living with other household members who receive income. Data from the March annual demographic supplement to the Current Population Survey (CPS) have been another early source of information about what is happening under welfare reform. With its large sample, detailed questionnaire, and timely availability, the March CPS does not have the major limitations of the leavers studies. All household members and their incomes are included, not just welfare leavers. However, until the March 2000 CPS, there was no sure way to identify transitions onto or off of welfare. Consequently, analysis of welfare reform, using March CPS data has focused on changes in the economic status of female family heads with children—the families most directly affected by welfare reform. This article tests key findings from the leavers studies with preliminary findings from the Survey of Income and Program Participation (SIPP), including information on employment rates, returns to welfare, and the economic status of persons once they leave the rolls. Overall, SIPP data support findings from the leavers studies and also provide both interand intra-temporal context SIPP data also are shown to be consistent with distributional analysis of CPS data. Moreover, SIPP's monthly data reveal how the income of leavers contributes to annual income trends in the March CPS.


An efficient synthesis of seven analogs of a naturally occurring saponin, indioside E, is described. The synthesis used a 3,4,6-O-protected D-galactopyranosyl thioglycoside as the key intermediate to enable regioselective glycosylation and one-pot multistep reactions. Antitumor activities of the synthetic saponins against a human hepatocellular carcinoma cell line BEL-7402 and a human breast adenocarcinoma cell line MCF-7 were evaluated by means of the CCK-8 assay. Analogs carrying trisaccharides with the D-xylopyranose in indioside E substituted with a D-ribopyranose and an L-arabinopyranose or with its diosgenin aglycon replaced with tigogenin exhibited similar antitumor activities as indioside E, but not other analogs.


Purpose
This paper aims to analyze the impact of the capabilities and strategies of the actors (micro-dynamics), learning process and networks (meso-dynamics) and institutions (macro-dynamics) in the evolution of the Brazilian ceramic clusters. Based on these experiences, managerial and policy implications are suggested.

Design/methodology/approach
Main data were gathered through 22 in-depth face-to-face interviews with managers and industry experts. The data were complemented by documentary analysis, including brand documents, descriptions of internal processes and Brazilian and international ceramics magazines and journals. In addition, the authors also use information from the previous experience of the authors who have been studying the sector for more than 15 years.

Findings
The paper provides empirical insights about the main characteristics of the evolution of two main Brazilian ceramic tiles clusters, as well as how there are different patterns of evolution among them. The results of this paper show that Brazilian ceramic tile clusters do not necessarily follow the life cycle model of their dominant industry, by proving evidence that different clusters in the same industry can follow different evolutionary paths.

Research limitations/implications
This paper shed light on a multi-level approach (micro, meso and macro) of dynamics of the clusters and how it impacts the cluster's life cycle. The micro-dynamics dimension was analyzed by the capabilities and strategies of local ceramic tile manufacturers. The meso-dynamics are being considered the localized learning processes, especially from those that arise from interactions, collaboration and networks carried by local and foreign suppliers. The macro-dynamics were considered by the role of local demand, factors conditions, institutions, historical legacy in the clusters' emergence along with path dependence mechanisms.

Practical implications
The paper includes implications for both clusters to promote innovation, particularly to keep and create market and technological leadership through the establishment of partnership between firms and clients, regulators and research centers and universities are crucial for innovation.

Originality/value
This paper fulfils an identified lack of attention regarding the under-appreciation of the context-specific issues such as the capabilities of the actors, networks and institutions that may influence the long-term development of clusters.


Dupilumab is a monoclonal antibody that blocks the shared receptor component for interleukin (IL)-4 and IL-13, thus inhibiting the signalling of both IL-4 and IL-13, and is approved for inadequately controlled moderate-to-severe atopic dermatitis (AD). However, an increased incidence of conjunctivitis has been detected in patients who received dupilumab compared with those who received placebo. Ocular surface disorders, including conjunctivitis, blepharitis, keratitis, eye pruritus and dry eye, are commonly reported adverse events in dupilumab-treated patients with AD, with conjunctivitis being the most dominant one. In this issue of the BJD, Akinlade et al. reviewed the results of published clinical trials and synthesized the available data on the incidence rates, disease course and associated baseline characteristics of patients who developed conjunctivitis in clinical trials of dupilumab in AD, asthma, chronic rhinosinusitis with nasal polyps (CRSwNP) and eosinophilic esophagitis (EoE). This analysis confirmed that patients with AD treated with dupilumab had greater incidences of conjunctivitis (8 6– 22 1%) than placebo-treated patients (2 1–11 1%) in most of the randomized, placebo-controlled AD clinical trials. Patients with AD were more likely to develop conjunctivitis if they had higher baseline AD severity, higher baseline levels of the serum biomarkers (thymus and activation-regulated chemokine and immunoglobulin E) and circulating eosinophil counts, or a selfreported history of conjunctivitis. In contrast, clinical trials of dupilumab in asthma, CRSwNP and EoE reported low and similar incidence rates of conjunctivitis in patients treated with dupilumab (0–1 7%) and placebo (0–3 3%). In all of the trials, most of the cases of conjunctivitis were mild or moderate, and most resolved while continuing dupilumab treatment. Furthermore, the relationship between treatment response and conjunctivitis incidence varied between treatment groups and studies. Patients who achieved high-level efficacy outcomes (Investigator's Global Assessment 0/1; 75% improvement from baseline in Eczema Area and Severity Index) in the monotherapy pool were less likely to develop conjunctivitis than those who did not achieve those outcomes. Patients with AD have a greater risk of conjunctivitis than the general population, and patients with more severe AD have a greater risk than those with mild disease. Allergic conjunctivitis and other ocular surface disorders are also common comorbidities of other atopic disorders such as asthma and allergic rhinitis. However, the incidence rates of conjunctivitis in all asthma trials were lower than those in the AD trials. At the same time, it is difficult to compare the baseline rates of conjunctivitis across various indications in the dupilumab clinical trials, because the trials differed in data collection. In the AD trials, data regarding baseline atopic comorbidities were collected using a targeted questionnaire, whereas in the non-AD trials, data regarding baseline comorbidities were collected via self-reporting or were noted at screening. In addition, it may be difficult to distinguish the symptoms of allergic rhinitis from those of allergic conjunctivitis. However, the discrepancies among the rates of conjunctivitis in clinical trials of dupilumab in AD and asthma, CRSwNP and EoE, as well as the lack of a dose–response relationship between dupilumab exposure and the occurrence of conjunctivitis, suggest that dupilumab itself may not be sufficient to cause conjunctivitis; other predisposing factors seem necessary. Currently, the pathogenesis of conjunctivitis in patients receiving dupilumab remains unknown. One suggestion is that Demodex mites may thrive due to the decreased IL-4 and IL-13 levels of ocular cytokines, leading to IL-17-mediated inflammation and a disease similar to ocular rosacea. However, IL-17 is decreased in dupilumab-treated patients and the disease course of conjunctivitis is too short in comparison with ocular rosacea. Dupilumab may increase OX40 ligand activity, which is involved in atopic keratoconjunctivitis. An increase in eosinophil counts after dupilumab administration might be another mechanism, as eosinophilic factors are elevated in the tears of patients with allergic conjunctivitis. IL-13 inhibition might be another possible mechanism because it has been implicated in ocular mucus production and the regulation of conjunctival goblet cells and, therefore, the quality of tears. In a phase II trial of lebrikizumab, a monoclonal antibody against IL-13, a trend for increased conjunctivitis was also noticed. Further studies are needed to understand the pathogenesis of conjunctivitis in patients receiving dupilumab. Conjunctivitis that develops after the administration of dupilumab for AD may be severe enough to necessitate stopping the therapy, indicating the importance of early prevention and management. Most of the reports suggested using hyaluronic acid eye drops, topical tacrolimus eye ointment, topical corticosteroid eye drops (e.g. fluorometholone, dexamethasone, hydrocortisone), artificial tears, compounded oily ciclosporin 1% eye drops, or antibiotic–topical corticosteroid combination therapies for the treatment of conjunctivitis during dupilumab treatment. Although one study found


The reaction of [{(Me2N)C(NiPr)2}2TiMe2] with 1 equiv of 2,6-dimethylphenyl isocyanide yields the terminal Ti imido complex [{(Me2N)C(NiPr)2}2TiNAr'] (Ar' = 2,6-Me2C6H3) (4). Complex 4 is an effective catalyst for the hydroamination of alkynes and reacts with H2NAr' to yield a complex with a transformed guanidinate ligand, [{(iPr(H)N)C(NiPr)(NAr')}2TiNAr'] (5).


Hepatitis A virus (HAV) causes an acute hepatitis associated with significant elevatation in liver enzymes. The liver is main target of HAV and extrahepatic manifestations are scarce. The diagnosis of acute HAV infection is made by the detection of anti-HAV IgM antibody in patients with the typical clinical presentation.. Here in, we present a 22-year old male presented with malaise, fever, nause, and intensive stomach ache. In physical examination, the patient had fever, jaundice, and hepatomegaly. Laboratory tests resulted in elevated liver enzymes. Abdominal ultrasonography demonstrated thickening of the gallbladder wall, and intramural air. As the patient's symptoms failed to regress in follow up laparoscopic cholecystectomy was performed. To sum up, HAV infection can be seen in all age groups, in developing countries, such as our country. It must be kept in mind that, although very rarely, HAV infections may exhibit extrahepatic complications.


The paper features the analysis of the psychological mechanism of educational-and-professional competence development, approving of a theoretical model of construction-transformation (changing) of educational activity into educational-and-professional as a functional system. The author considers knowledge, skills and abilities as means of the competence development.


A cosmetic treatment method for treating a selected region of the abdominal area and the buttock of the body of a subject not baby, to achieve a cosmetically beneficial reduction of subcutaneous adipose tissue, comprising: using at least one feedback device to monitor temperature and / or crystal formation configured to provide feedback information concerning the temperature of the subject's skin or crystal formation; and cooling the skin of the subject, based on information received from at least one feedback device, in a region where the reduction in subcutaneous adipose tissue desired by cooling said region sufficient to selectively disrupt rich cells lipids same, and simultaneously therewith maintain the subject's skin at a temperature wherein non rich cells next lipids to the cooling medium do not break, and wherein non lipid-rich cells surrounding fat tissue subcutaneous not broken, wherein the lipid rich cells are cooled to a temperature from about -10 to about 25 for a period of time from 10 seconds to 30 minutes.