Atom probe tomography (APT) is emerging as a key nanogeochemistry technique for diverse geoscience applications. Estimating stoichiometric mineral compositions is particularly challenging for features at nanoscale. APT provides reliable measurements for metallic systems but the reliability for oxides is problematic, notably due to oxygen deficit. Here, we use laser‐assisted APT to compare results for spinel and garnet crystals. APT compositional results were compared with those by electron microprobe to determine the possible APT analytical inaccuracy. Extensive data processing was accomplished, including correlation histograms, 2D ion distribution maps and 1D elements concentration profiles, to disclose the possible mechanisms leading to mineral stoichiometry biases. Multiple events and neutral molecules formation are probable the main processes responsible for atom deficit. In particular, the amount of the same isotope–same charge state ion pairs correlated with aluminium and oxygen deficits suggests that the co‐evaporation in a dead space–dead time window could lead to a significant decrease of detected ions. Also, molecular species dissociation and direct current evaporation could partially account for further atom loss. Overall, better APT compositional estimation was obtained for spinel, which has lesser variation in lattice sites and greater overall lattice symmetry, higher thermal conductivity and lower band gap compared with garnet.


OBJECTIVE—We sought to determine if any common variants in the gene for vascular endothelial growth factor (VEGFA) are associated with long-term renal and retinal complications in type 1 diabetes. RESEARCH DESIGN AND METHODS—A total of 1,369 Caucasian subjects with type 1 diabetes from the Diabetes Control and Complications Trial (DCCT)/Epidemiology of Diabetes Interventions and Complications (EDIC) Study had an average of 17 retinal photographs and 10 renal measures over 15 years. In the DCCT/EDIC, we studied 18 single nucleotide polymorphisms (SNPs) in VEGFA that represent all linkage disequilibrium bins (pairwise r2 ≥ 0.64) and tested them for association with time to development of severe retinopathy, three or more step progression of retinopathy, clinically significant macular edema, persistent microalbuminuria, and severe nephropathy. RESULTS—In a global multi-SNP test, there was a highly significant association of VEGFA SNPs with severe retinopathy (P = 6.8 × 10−5)—the four other outcomes were all nonsignificant. In survival analyses controlling for covariate risk factors, eight SNPs showed significant association with severe retinopathy (P < 0.05). The most significant single SNP association was rs3025021 (hazard ratio 1.37 [95% CI 1.13–1.66], P = 0.0017). Family-based analyses of severe retinopathy provide evidence of excess transmission of C at rs699947 (P = 0.029), T at rs3025021 (P = 0.013), and the C-T haplotype from both SNPs (P = 0.035). Multi-SNP regression analysis including 15 SNPs, and allowing for pairwise interactions, independently selected 6 significant SNPs (P < 0.05). CONCLUSIONS—These data demonstrate that multiple VEGFA variants are associated with the development of severe retinopathy in type 1 diabetes.


The results from oscilloscope measurements focused on
determination of power losses in dielectric of surface and
coplanar DBD. In both types of discharges, these losses
amounted to 3% of the total power supplied to the discharge.


Quenching chamber arrangement (1) for erasing a switching arc, with an arc splitter stack (2), the extending plurality of mutually parallel and each extending between an arc running face (8) and one of said opposite rear face (9) quenching plates (4), wherein between the quenching plates (4) a gas-releasing under arcing material (M) is arranged, characterized in that the gas-releasing material (M) in a comb-shaped element (3) is included, which is inserted from the rear side (9) forth in such a way into the arc splitter stack (2) is that the one prong (14) of the comb-shaped element (3) rests between two adjacent quenching plates (4).


Linear trends in the total, tropospheric, and stratospheric column NO2 contents obtained from satellite measurements using the Ozone Monitoring Instrument are compared to NO2 trends obtained from ground-based measurements at NDACC stations. For the Zvenigorod station, where vertical distribution of NO2 is retrieved from the ground-based measurements, a satisfactory correspondence of the trends calculated from satellite data to the trends calculated from measurements at the station has been obtained. For other stations where only the total column NO2 contents are measured, the correspondence of the trends calculated from satellite data and trends obtained from ground-based measurements may generally is less satisfactory.


Abstract Tropical cold point tropopause (CPT) characteristics have been calculated using ECMWF reanalyses and high resolution radiosonde soundings obtained in TOGA COARE as well as operational sounding data. It is found that ECMWF reanalyses are suitable for investigating the morphology of the tropical CPT and the variabilities of the tropopause over the entire Tropics, despite an almost constant one-side warm bias. The daily locations of the tropical coldest CPT are clustered over the western Pacific warm pool region in January and spread out longitudinally as the year progresses. During the Indian summer monsoon, the locations of the coldest CPT are deflected northward. The influences of the quasi-biennial oscillation (QBO) and the El Nino–Southern Oscillation (ENSO) on the tropical CPT have been separated using bivariate regression. The stratospheric zonal wind shear at 50 mb leads the variation in the tropical CPT temperatures by about 6 months. The QBO signature in the tropical CPT is mainly zonally ...


Disparities exist in the international management of multiple sclerosis (MS). For example, when stratified by income, only high-income countries have a high rate of availability of all disease-modifying therapies (DMTs); as income decreases, the availability of DMTs declines rapidly, such that even upper-middle-income countries commonly only have access to first-line therapies but not the newer, potentially more potent agents, and low-income countries have no access to DMTs.1 As newer DMTs associated with greater risk of toxicity become more available, providers in those countries are playing catch-up to the international community in providing guideline-level MS care.2 This adds to the challenge already described by providers where advanced MS treatments are available: it is difficult to remain current on important domains related to DMT prescription, including selecting the correct DMT for a specific patient's characteristics, safety data, and monitoring guidelines, resulting in a call for targeted continuing medical education.3 Taken together, it is in the interest of the international MS community to have providers with more experience using these DMTs spread the knowledge they have gleaned to providers in countries where these same treatments are emerging. Our videoconference-based education and case consultation program can efficiently meet this need.


The wireless service software is the C++ client application developed with CORBA and JaguarCTS technology. In three-layer structure, the client terminal is simple and universal, and most of the logic applications are reside on middle server in network. The middle server accesses the database, and completes the clients requests. The load in the network was balanced, the compatible problem among different operation systems and protocols was resolved, and integration of distributed software was realized with middle-ware technology. On the base of three-layer structure of JaguarCTS, the client terminal can be extended, establish agility system structure. Data channel was gotten through, CORBA JaguarCTS client application was established using C++ Object-Oriented technology, and the wireless terminal directly querying network database was realized.


This paper evaluates Nordhaus's neoclassical complaints about the Stern Review from the vantage point of classical growth theory. Nordhaus criticizes the Stern Review because it uses a discount rate that is well below the market rate of return on capital. From the perspective of classical growth theory, Nordhaus's belief in choosing preference parameters for the social planner based on observed market rates of return is equivalent to assigning the preferences of the capitalist agents to the social planner. This equivalence is an implication of the Cambridge Theorem, which interprets the Ramsey equation as the saving function of the capitalist agents.


The authors describe a stereo audio processor chip with analog performance that is achieved by a tradeoff among several important requirements including distortion, noise, DC offsets and crosstalk. In the system, each source selector has seven audio inputs and three buffered outputs. A fourth source selector output is connected to a programmable volume controller with an amplification range between +23 dB and -79 dB in 1-dB steps. The I/sup 2/C transceiver provides communication with a microcontroller by means of a two-wire serial bus. The decoder stores and decodes the received control data and drives the switches in the analog blocks. The digital part also contains a power-on-reset and power-dip control. The system architecture is determined by the low distortion target. The chip's performance is summarized in a table.<<ETX>>


What determines the Chinese firms' outward FDI (foreign direct investment) entry mode choice, and do they behave differently from the firms from developed countries? To answer this question, this exploratory study firstly summarizes the attributes of the FDI entry modes, including greenfield investment, acquisition, and joint venture. Further based on the different attributes of these three modes, we analyze how Chinese firms choose the entry mode from the role the ownership and network perspectives, which are the important characteristics of Chinese firms.


Trichoderma reesei M18.2 и коммерческим препаратом амилаз "Термамил" достигала 43% абсолютно сухого веса при 60 °С.The strain of Trichoderma reesei M18.2 is capable of an active synthesis of xylanases and cellulases on the waste of spirit production – distillery grains. During the submerged cultivation on the grains, the activity of xylanases and cellulases reached maximum value (530 IU/ml and 3.3 FPU/ml respectively) on the fourth day. We investigated the composition of the carbohydrate fraction from the fodder grains of Tatarstan. The content of xylans in this fraction made up 11.4%. The depth of enzymatic hydrolysis of raw grain by the investigated hydrolytic enzymes Trichoderma reesei M18.2 and the commercial amylase preparation "Termamyl" reached 43% of absolutely dry weight at 60°C.


Security in the heterogeneous and complex network is very challenged for administrators. They need to handle with a lot of devices, and perform the task of protection and prevention plan for securing the network from the threats. The Security Information and Event Management (SIEM) is one of the most common tools that helps administrators to deal with current situation. It helps to manage and identify the threats. Moreover, it will initiate a proper an action to protect the network against the right threats and also generate a report for the administrators. However, the amount of threats is increasing rapidly, and the variation of threats is also another issue for identifying. The Latent Semantic Analysis (LSA) was proposed in this paper to help alleviate these problems. It would improve the performance by reducing the unnecessary noise in a huge data generated from devices. It is also used to detect a similar threat pattern relying on similarity between threats and events/logs. The experiments showed that LSA approach can help eliminating not significant data used in the threat identifying process without degradation of the accuracy.


IN THE last 15 years the practical possibilities of the fluorogases as dielectrics have increased and their use has been demonstrated in several applications.1,2 Sulfur hexafluoride and Freon 12 are available economically in large quantities and for this reason have received extensive studies.3,4,5 However, fragmentary data showed that many compounds, although not yet available in large quantities, held promise and needed comprehensive evaluations.


Abstract User requirements, organizational change, government regulations, and politics are all factors that any organization embarking on a systems development project must take into consideration. These factors, plus that of general societal trends, have an even greater significance for governmental IT organizations that are planning to implement new applications. IS managers in government, as well as those in industry, can use the planning framework presented in this article to manage these factors, as well as the overall requirements and systems planning process.


We report on how it is possible to flash-freeze, stain and image at very high magnifications microtubules stabilized with Taxol, using high electron doses, without recording modifications during illumination. This staining mechanism is used since a few years to consistently result in well-defined microtubules [1-2] for tomography experiments. Tentatively, the unexpected dose resistance after elimination of unbound water from the grids, by sublimation before irradiation, may reflect changes in absorption of the materials in the sample at wavelengths larger than visible light. Such radiation would result from parasitic scattering of electrons from the heavy metals in these samples. Diameter of resulting microtubules measured between 25 and 32 nm. High electron dose is reflected in the high definition of these images, acquired with Poisson counting statistics. With such definition, some deformations of microtubule, possibly induced by interaction with stain or substrate, appear. As well, many irregularities on the surface of these microtubules are also present. Because of the high purity of this sample, the large constructs found on the surface of supporting film may derive from an unexpected association of tubulin, possibly involving material from the substrate. These large aggregates bind the stain. Very small-size (diameter ~20Å) globular stained aggregates were found in a control experiment using bovine-serumalbumin (BSA) instead of tubulin. BSA is known to spontaneously aggregate.


Seabottom profiling using a multibeam echosounder is a well‐known method to acquire a high‐resolution and high‐density data set for bathymetric mapping of survey area. The use of multibeam echosounder backscatter signals for bottom roughness characterization is a modern technique. Here, the model results of seabottom backscatter data using a hydrosweep‐multibeam system, from some of the geologically well‐known areas of Southern Oceans, are presented. Using the capabilities of multibeam systems, angular backscatter strengths are determined employing various corrections. Different bottom backscattering modeling techniques like the composite roughness [Jackson et al., J. Acoust. Soc. Am. 79, 1410–1422 (1986)] and two‐layer Helmholtz–Kirchhoff model [Talukdar et al., J. Acoust. Soc. Am. 97, 1545–1558 (1995)] for estimation of bottom roughness is applied. Various seabottom parameters like root‐mean‐square (rms) relief height, correlation lengths, attenuation coefficients, and layer thickness using the two‐laye...


NASA uses the Shuttle training aircraft (STA) to train the Shuttle pilot astronauts. Although as compared to the Shuttle, STA is a small aircraft, it does simulate, with some model following errors, the aerodynamics of the Shuttle. In this paper, we show how these differences can be reduced significantly by using a new pitch predict controller and a new adaptive fuzzy controller. In particular, we show how the collaborative work between NASA Ames and the Shuttle Training Branch of Johnson Space Center has improved the accuracy of STA model following from its current level of 71% to 91% which is equivalent to a 69% error reduction.


To explore the association between pulmonary artery systolic pressure (PASP) and success to wean from mechanical ventilation in COVID-19 patients.Thirty-four critically ill COVID-19 patients who had been placed on ventilator support were enrolled in this retrospective study and were divided into two groups: the weaning success group (group I) and the weaning failure group (group II). Physical examination, echocardiography, and routine laboratory test data were collected. The levels of troponin I, myoglobin, interleukin 6, and D-dimer were significantly lower in group I than in group II. The interventricular septum end-diastolic thickness (IVSd) was thicker (14.00 [13.50‒15.00] mm) and the PASP was higher (61.63 ± 13.53 mmHg) in group II. Logistic regression analysis showed that D-dimer and IVSd were factors associated with ventilator weaning. The odds ratio (OR) of D-dimer was 0.81 (95% CI 0.69‒0.95) and the OR of IVSd was 0.16 (95% CI 0.045‒0.59). Cox analysis revealed that the adjusted hazard ratio (HR) for a 1-mmHg increase in PASP was 0.94 (95% CI 0.90‒0.97) for weaning events (P < 0.001). PASP was negatively correlated with the PaO2:FiO2 (r = -0.48, P < 0.01). A receiver operating characteristic curve showed that the best cutoff value of PASP for ventilator weaning was 39.50 mmHg, with a sensitivity of 100% and a specificity of 96.15% PASP was an independent risk factor for the difficulty of weaning severely ill COVID-19 patients off mechanical ventilation. PASP can be used as one of the indicators for evaluating the condition of COVID-19 patients.


Neural networks usually require vast amounts of labeled training data. In this dissertation, we propose an approach to solve this problem: "Learning bay Association". This training schedule is suitable for any embedding learning task such as classification, domain adaptation or clustering. The key idea is to "associate" training examples for which labels are known with unlabeled examples. A novel cost function facilitates state-of-the-art results with significantly less labeled training data.


World Class Manufacturing offers a consistent and rigorous problem-solving framework for identifying the scope of the problem, eliciting participant views about problem causes and system connections, and identifying policy levers. Reliability, quality, and cost are linked, with higher quality being associated with higher reliability. Iran auto part industry has
achieved many capabilities in supplying auto parts in the country. However, most of the Iranian auto part producers have not acceded to global markets. The purpose of this research is identifying the most important export barriers in this industry. So, a theoretical framework of export barriers based on variables effect on competitive advantage in global markets, export barriers, and export performance is developed. It includes seven variables: factor
condition, demand conditions, related and supporting industries, firm strategy and structure, government, target market conditions and chance. The data used in this research was collected through a survey of top managers of auto- parts producing companies in the Tehran province. The results show that all 7 main variables were supported as export barriers by the
respondents, though some of the measures in these variables were not recognized as an export barrier. Also, their priority was determined


Aims:  The study of proteolytic activity and examination of proteinase gene region organization in proteolytically active Lactobacillus plantarum strains from different natural sources.


The safety integrity of reaction system of low density polyethylene(LDPE) plant is mainly depending on the availability of emergency relief system.A state-of-the-art precise process safety analysis method was applied to evaluate the redundancy requirement of emergency relief valves of LDPE plant.Took relief valve opening characteristic into consideration,a modified emergency relief model was proposed by revising of the pressure relief model which was put forward by DuPont.Numerical simulation method was used to study run away situation in tubular reactor.The pressure fluctuation in reactor under different run away situations,e.g.relief valves operation strategy,valve operation speed as well as run away location were also studied.The conclusion of 2 out of 5 required relief valves under decomposition situation was obtained,which was benefit for the assessment of safety integrity level(SIL) of emergency SIS system.Detailed safety requirement specification of pressure relief system for reaction process was also discussed,which was benefit for improvement of safety integrity of process installations.


The vertical ultimate bearing capacity of a single pile is an important parameter required in the design of pile foundation. The vertical compressive static load test of a single pile is the most reliable method to determine the vertical ultimate bearing capacity of a single pile. However, the load test cost is high and the cycle is long. In the early stage of small and medium-sized projects or large-scale projects, the conditions for carrying out the vertical compressive static load test of a single pile are generally not available. Based on the geotechnical engineering of a coal-fired power station in Southeast Asia, the vertical ultimate bearing capacity of a single pile is estimated by using the results of cone penetration test (CPT) and standard penetration test (SPT), and the ultimate bearing capacity is tested by high strain dynamic test. Compare various estimating value and high strain dynamic testing value to static load test value with ultimate vertical bearing capacity of a single pile, and then obtain the reliability of vertical ultimate bearing capacity of a single pile by means of CPT and SPT in this area. By means of the research results of this paper, obtain the vertical ultimate bearing capacity of PHC pipe pile quickly and accurately in this area for similar engineering design. Ultimately achieving the goal of shortening the construction period and reducing geotechnical investigation cost.


This paper compares the incentives of a party to acquire information prior to negotiating contractual terms with a second party. Two legal regimes are compared: disclosing information before negotiations start is mandatory or it remains voluntary. By assumption, information can only truthfully be disclosed but, under voluntary disclosure, the fact that no evidence was found cannot credibly be communicated. If the party that may acquire information enjoys encompassing bargaining power, the incentives to acquire information will be excessive relative to first best quite generally. Otherwise, more surprisingly, acquisition incentives turn out insufficient even under voluntary disclosure for an informational setting referred to as selfish acquisition. For another setting, referred to as cooperative acquisition, the incentives under voluntary disclosure are even lower as compared with mandatory disclosure. All results hold independently of the underlying bargaining structure and equilibrium selection as exclusive use of constraints is made that hold for equilibrium payoffs from any bargaining game.


To investigate the possibility of the maternal transmission of BSE,PrP mRNA expression in different tissues of cow reproductive system was quantified using calibrated highly sensitive externally standardized real-time RT-PCR.Absolute quantification was achieved using a standard curve constructed for the target gene PrP and the housekeeping gene GAPDH.The results showed that PrP mRNA was present in all regions of the reproductive system of male and female cows.In bulls examined,the spermary,spermary appendix and spermaduct all showed high level of PrP mRNA expression (1.16±0.0010, 1.81±0.0056,0.68±0.0038);moderate level of the expression (0.47±0.0018,0.25±0.0007,0.28±0.0007) were detected in the prostate,spermatic gland and urethral gland and low level of expression (0.18±0.0017) in the penis.In comparison, cows showed high level of PrP mRNA expression (2.53±0.0008,1.75±0.0098) in the placenta and the uterus;moderate level of expression (1.55±0.0038,1.45±0.0064) in the ovary and fallopian tube;and low level of expression (0.57±0.0036) in vagina.The results are useful in elucidating the normal PrP gene expression and its normal physiological functions,and to confirm the role of the reproductive system in the maternity transmission route of the BSE.


Just like a double-edged sword,the sci-technical achievements have not only the positive value,but the negative value,too.The unreasonable use of science and technology has resulted in some serious problems as environmental pollution,the ecology imbalance and so on.The paper makes discussion from the aspects of the sci-technical subject,namely the scientists,the ethics implied in the science and technology,the reform of the sci-technical system,and its ultimate objectivesc.


Abstract Atmospheric surface pressure can be remotely sensed from a satellite by an active instrument which measures return echoes from the ocean at frequencies near the 60 GHz oxygen absorption band. We optimize the instrument by selecting its frequencies of operation, transmitter powers and antenna size through a new procedure based on numerical simulation which maximizes the retrieval accuracy. The predicted standard deviation error in the retrieved surface pressure is 1 mb. In addition the measurements can be used to retrieve water vapour, cloud liquid water and sea state, which is related to wind speed.


Free radical-generated F2α-isoprostanes are a group of compounds with vasoconstrictor properties. To investigate whether estradiol exerts antioxidant actions modifying F2αisoprostane production, cultured human umbilical vein endothelial cells were exposed to estradiol and other compounds and F2α-isoprostanes measured in culture medium. Exposure to 1 and 10 nM estradiol during 24 hours reduced F2α-isoprostane production by 36% and by 49%, respectively (p < 0.001 vs. control). Exposure to antiestrogens alone (ICI 182780 or EM-652) slightly reduced F2α-isoprostanes (p < 0.05 vs. control), but much less than estradiol (p < 0.05). ICI 182780 reversed the estradiol-induced reduction of F2α-isoprostane concentration (p < 0.05). Along with time course analysis, these results suggest that estradiol effects were mediated through both estrogen receptor-dependent and -independent mechanisms. Progestogens alone (progesterone or medroxyprogesterone acetate) did not modify F2α-isoprostanes production at any of the tested concentrations (1, 10 and 100 nM). Progesterone completely reversed estradiolinduced reduction of F2α-isoprostane production (p < 0.05 vs. control and estradiol) but medroxyprogesterone acetate did not (p < 0.05 vs. control).


The piezoelectric actuator is an electromechanical device which can transduce energy between electrical and mechanical. Usually it is used for managing extremely small displacements up to micro range. Due to piezoelectric actuator have characteristic of high stiffness, simplicity, fast response, and low wear and tear, it is widely used nowadays in industries such as electrical engineering applications and high precision mechanical system. However, piezoelectric has the disadvantages in terms of its dielectric material properties and hysteretic behaviour inherent causing inaccuracy behaviour to maintain the output displacement. To overcome this problem a PID controller is designed to regulate the output displacement and minimize the system error. The parameters are selected by using SISO Tool method. In this paper, PID controller design methods of piezoelectric actuator were presented to control the output displacement thus obtaining a stable and efficient system. Simulation and experimental test were conducted to verify of the proposed controller.


Changes to an extant model of forest growth and transition that allow an evaluation of the consequences of beech bark disease are outlined. Required are a function to scale beech growth for the effects of beech bark disease, a function to predict beech mortality from beech bark disease, and a function that predicts root-sprout regeneration of beech.


493Background: Treatment paradigms for borderline resectable pancreatic cancer (BRPC) continue to evolve with increasing use of neoadjuvant chemotherapy (NAC) and chemoradiation (NACR). Variations ...


MANY BUSINESS OWNERS, SEEKING FLEXIBLE, COST‐EFFECtive employees to flesh out their workforce, try tapping workers under the age of 18. And it's a smart, cost‐effective strategy—with one big "but": Be sure you adhere to the child labor laws—or risk facing hefty fines.


Supernova (SN) siblings -- two or more SNe in the same parent galaxy -- are useful tools for exploring progenitor stellar populations as well as properties of the host galaxies such as distance, star formation rate, dust extinction, and metallicity. Since the average SN rate for a Milky Way-type galaxy is just one per century, a large imaging survey is required to discover an appreciable sample of SN siblings. From the wide-field Zwicky Transient Facility (ZTF) Bright Transient Survey (BTS; which aims for spectroscopic completeness for all transients which peak brighter than $r{<}$18.5 mag) we present 10 SN siblings in 5 parent galaxies. For each of these families we analyze the SN's location within the host and its underlying stellar population, finding agreement with expectations that SNe from more massive progenitors are found nearer to their host core and in regions of more active star formation. We also present an analysis of the relative rates of core collapse and thermonuclear SN siblings, finding a significantly lower ratio than past SN sibling samples due to the unbiased nature of the ZTF.


Toxoplasomsis is a zoonotic disease resulted from toxoplasma infection,This paper reports ten monsters that suffered from congenital cleft lip and palate accompanied antigens(RCEP,COA test) were positive.Toxoplasma antibodies (IHA,IFA,RIPEGA test) in mothers' serum were also positive.Microscopic examination revealed toxoplasma trophozoites and pseudocysts in the tissue of cleft lip and palate as well as viscera.In addition,We used SPA method to reveal toxoplasma in the tissue.We indicate that toxoplasma infection of pregnant women is one of the cause of monsters.It is the important biological factor and closely related to eugenics.Stomatologists must pay attention to this etiology.


This paper reviewed and analyzed literature on lean six sigma (LSS) methodology tools and its applications in the manufacturing industries. Lean manufacturing deals with the process improvement and effective productivity of an organization through elimination of waste. Six sigma on the other hand, is a concept of improving plan that is capable to reduce process/operation variation of an organization. The lean-six-sigma has been practiced mostly in the developed countries along organization of time, but its importance both in the manufacturing processes and management activities cannot be neglected. The aim of this paper is to highlight the benefits of these concepts and how the two principles are merged in industries to improve productivity effectively, reduce waste, and increase the product quality level as well as ensure customer/stakeholder satisfaction. The paper also discussion various lean six sigma methodology tools adopted by small and medium scale industries to achieve improved product quality level and process or operation efficiency. This lean-six-sigma can be implemented or applied to any kind of industry for better productivity through continuous improvement on the business activities. This study would help any kind of manufacturing industry to find a solution on how to compete favorably in a competitive business environment with a dynamic market system and also equally be used by other researchers to enhance their literature.


This chapter introduces some of the challenges in valuing programs and policies that seek to serve the public interest. After examining variations in current practice, the author addresses ways of managing the use of valuing methodologies according to the contexts in which they work best. This, in turn, supports conclusions about desired types of balance in our methods of valuing in the field of evaluation. ©Wiley Periodicals, Inc., and the American Evaluation Association.


The article suggests a definition of the professional reliability of Physical Education teacher. The given definition was preceded by a detailed analysis of a number of approaches and attitudes to the problem of reliability. This analysis led to the development of the structural and functional model of the professional reliability of physical education teacher. The main structural element of this model is the teacher, who is considered at three levels: individual, subjective and personal. Professional activities are carried out under the influence of variative conditions of vocational and educational environment. The main indicators of this environment are: the conditions and organization of work, labor stimulation, normative documents, sports and pedagogical staff, student groups and others. Results of the interaction of the teacher with the external environment in the labor process have the following indicators: inerrancy, efficiency and productivity, which together indicate his professional reliability. The construction of this model allows us to identify the main ways of studying teacher's psychological characteristics, which make for his professional reliability.


Some thiourea-derived brighteners of acid copper sulfate plating baths were analyzed by cyclic voltammetric stripping (CVS). Results indicated that the values of CVS relative rate parameters (A/Ag) were related to the wetting abilities of these brighteners


P53 is frequently mutated in most human cancers, including glioblastoma (GBM). Many p53 mutants acquire gain-of-function oncogenic effects through only partially understood mechanisms. To investigate the role of gain-of-function mutant p53 (MUT-p53) in GBM, we performed ChIP-seq of wildtype p53 (WT-p53) and MUT-p53 GBM cell lines. Among 2834 unique peaks reads in MUT-p53 cells, we found 242 long non-coding RNAs (lncRNAs) with up to 145 fold enrichment relative to WT-p53. LncRNAs regulate many molecular and cellular functions, including gene expression, cell proliferation, death, cancer stem cell renewal and differentiation. We selected lncRNAs SOX21-AS1 and LINC00643 with highly enriched binding by MUT-p53 and investigated their expressions and functions in the p53 pathway. We performed ChIP confirmation of MUT-p53 binding to the promoters of these lncRNAs. We found that these lncRNAs are deregulated in GBM and correlated with GBM patient survival in the TCGA database. To investigate the functions of these LncRNAs, we knocked down their expressions by siRNA, and found significant cell death induced by si-SOX21-AS1, but not by si-LINC00643. Overexpression of LINC00643 in GBM cells led to inhibition of GBM cell proliferation, migration, invasion and in vivo xenograft growth. LINC00643 mediated the effects of MUT-p53. Co-expression of human LINC00643 and its mouse homologous in a RCAS transgenic mouse model of GBM reduced tumor growth and improved animal survival. To elucidate the mechanisms of action of the lncRNA, we performed Chromatin Isolation by RNA purification high-throughput sequencing (CHIRP-seq) to identify its binding targets. We found that LINC00643 binds to HIF1a 5' promoter/enhancer region. Overexpression of LINC00643 in GBM cells at hypoxia growth condition reduced HIF1a mRNA and protein expression. Our study shows for the first time that gain-of-function mutant p53 regulates a subset of lncRNAs and that the lncRNAs mediate the oncogenic effects of the MUT-p53 in GBM.


BACKGROUND: Malnutrition in pregnant women has been known to bring effects on the mothers' and infants' health. Food or nutrient supplementation is now being used to correct the problems. Moringa Oleifera leaves and honey are the two types of natural supplements used by pregnant women.
AIM: This systematic review aimed to evaluate the potential effects of Moringa, honey, and both compared to ironfolic acid supplements given to pregnant women on the pregnancy outcomes.
METHODS: A systematic review was conducted to evaluate the extent of the benefits of the supplementation of M. Oleifera, honey, or both against pregnant women. There were seven studies which are conducted in Indonesia on this topic.
RESULTS: This review shows that M. Oleifera leaves in the form of extract and powder as well as honey could improve maternal weight and hemoglobin, and baby's birth weight. Moreover, both interventions could reduce stress and protect mothers and their babies from negative effects of oxidative stress.
CONCLUSION: Nevertheless, efforts are needed to formulate a recommended dose as adequate supplements for pregnant women.


The invention discloses a diagnosis and treatment business realizing method based on a mobile internet. The method comprises a medical service system and a diagnosis and treatment follow-up visit business system of the mobile internet, wherein the medical service system is used for carrying out the right control of user data systematic management and decentralization domain on patients and doctors; carrying out recording, storage, management and right control on characters, pictures, documents and audio and video information data of personal information, history of genetic diseases, health data and physical examination data of the patients; synchronously increasing, deleting, editing and managing data in real time by the doctors and the patients by virtue of intelligent terminal equipment or personal computer equipment in a medical follow-up visit process.


Abstract. In this paper the dynamic response of a complex double-string system traversed by extreme moving load is considered. The paper includes the study of a dynamic behavior of a finite, simply supported double-string flexible complex system subject to moving forces with a constant velocity on the top string. The strings are identical, parallel one upon the other and continuously coupled by a linear Winkler elastic element. The moving loads are around an extreme position of the shear wave velocity of the strings. The classical solution of the response of complex systems subjected to forces moving with a constant velocity has a form of an infinite series. But also it is possible to show that in the considered case part of the solution can be presented in a closed, analytical form instead of an infinite series. The presented method to search for a solution in a closed, analytical form is based on the observation that the solution of the system of partial differential equations in the form of an infinite series is also a solution of an appropriate system of ordinary differential equations. The closed solutions take different forms depending if the velocity of a moving force is smaller, equal or larger than the shear wave velocity of the strings. This follows from the fact that in string wave phenomena may occur. The solution for the dynamic response of the composite strings under moving force is important because it can be used also in order to find the solution for other types of moving loads. The double string connected in parallel by linear elastic elements can be studied as a theoretical model of composite system or prestressed structure in which coupling effects and transverse wave effects are taken into account.


Objectives To establish the pattern of change in individual scientific production over the career of medical researchers. Design Retrospective cohort based on prospectively collected data in a hospital information system. Setting Multicentre university hospital in France. Participants Two distinct populations of 1835 researchers (full professors vs non-academic physicians) having produced 44 723 publications between 1995 and 2014. Main outcome measures Annual number of publications referenced in Medline/PubMed with a sensitivity analysis based on publications as first/last author and in high impact journals. The individual volume of publications was modelled by age using generalised estimating equations adjusted for birth cohort, biomedical discipline and academic position of researchers. Results Averaged over the whole career, the annual number of publications was 5.28 (95% CI 4.90 to 5.69) among professors compared to 0.82 (95% CI 0.76 to 0.89) among non-academic physicians (p<0.0001). The performance curve of professors evolved in three successive phases, including an initiation phase with a sharp increase in scientific production between 25 and 35 years (adjusted incidence rate ratio 102.20, 95% CI 60.99 to 171.30), a maturation phase with a slower increase from 35 to 50 years (2.10, 95% CI 1.75 to 2.51) until a stabilisation phase with constant production followed by a potential decline at the end of career (0.90, 95% CI 0.77 to 1.06). The non-academic physicians experienced a slower pace of learning curve at the beginning of their careers (42.38, 95% CI 25.37 to 70.81) followed by a smaller increase in the annual number of publications (1.29, 95% CI 1.11 to 1.51). Conclusions Compared to full professors, non-academic physicians had a poor capacity to publish, indicating a low productivity when medical doctors have limited time or little interest in undertaking research. This finding highlights the potential for rethinking the missions of medical doctors towards an enlargement of scientific prerogatives in favour of progress in global knowledge.


Bojan Bujić (email@example.com) is an Emeritus Fellow of Magdalen College, Oxford. He taught at the universities of Reading (1969–78) and Oxford (1978–2005) and has published extensively in the fields of Italian sixteenthand early seventeenth-century music, aesthetics of music and Austro-German modernism. Among his publications are Music in European Thought 1851–1912 (CUP, 1988) and Arnold Schoenberg (Phaidon, 2011).


The optimum feeding proportion of methane and oxygen for cultivation of Methylomonas flagellata was defined in batch cultures. The highest productivity was obtained by feeding equi-volumes of methane and oxygen (CH4 17%+air 83%). In this condition, the dissolved methane and oxygen were found to be simultaneous growth limiting factors with elevation of cell density. M. flagellata showed a specific growth rate of 0.19 hr−1 under this optimal condition, and cell density reached 23 g/liter after 72 hr cultivation.


This paper investigates the abnormal tone dynamics of news media articles about firms near earnings announcements and how it relates to earnings results and the stock market. We document a post–earnings abnormal tone drift, suggesting inertia in the media opinion. Also, we find that negative cumulative abnormal tone at the earnings events predicts a subsequent stock price reversal. Higher investor's attention, due to event coverage by the three type of sources (i.e., newswire, newspaper, web publication), amplifies the reversal. Finally, a high level of abnormal share turnover at those events suggests that the reversal is due to overreacting investors.


The authors focus on the concern that children in the U.S lack exposure to the natural environment. The authors state that 80 percent of the Americans live in cities. According to the authors, the use of technological devices such as iPods and video games keeps kids from exposure to natural world. Information on the efforts of the U.S Forest Service to address the issue is also offered.


Abstract
We discuss the value of a Bachelor's Degree in Entrepreneurship. We do this in part by responding to some of the most common criticisms for the perceived shortcoming of the degree. Some of the issues addressed include the benefit of a major over a minor; the advantage of experience versus education; and the degree's effectiveness in preparing students for an entrepreneurial career. We base most of the responses on our experiences at Loyola Marymount University. We conclude by pointing out that the Entrepreneurship degree can serve as a powerful foundation for the right type of students.


Recent pollution by organochlorine compounds (OCs) has been found to cause ecological damage, initially by causing declining populations. Poisoning of animals having high OC levels was often found to be similar to poisoning of man and animals in dioxin accidents. Dioxin toxicity has been shown to occur from structural binding of the toxin to a cytosolic receptor, and this action has been extended to many planar and coplanar aromatic OCs which are released into the environment from pesticide uses, dumping of chlorophenol wastes, chlorobleaching of pulp, chlorodisinfection of water, and combustion of OCs or chloride-containing materials. More efficient combustion has been developed to restrict OC emissions. Recent analyses of wildlife samples have shown that certain planar or coplanar aromatic chlorohydrocarbons and ethers, instead of the notorious polychlorinated dibenzo dioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs), could be the most important receptor-specific environmental toxins. Despite the fact that the pollution of the aquatic ecosystem by the forest industry in many areas is decreasing due to improved processes and treatment plants, organochlorine bleaching products still appear to have importance due to harmful discharges, especially since they still cause taste problems in seafood due to the bioaccumulation of chloroanisoles and chloroveratroles.


Through studies on the influences of plumbum and silver on the determination of aurum in anode mud, an improved active carbon - iodine quantity analyzing method that adding sodium sulfate after the end of solution sample, and changing the thickness of hydrochloric acid during filtering and cleansing to eliminate the defect of uneasy determination for the end point and the influences leading a lower result during the next math, is brought forward in this paper. Compared with the method of py-rometallurgy, the method has got the merits of lower cost, shorter process and more correct result.


ABSTRACT In this paper, we consider periodic metric graphs embedded in , equipped by Schrödinger operators with bounded potentials q, and -type vertex conditions. Graphs are periodic with respect to a group isomorphic to . Applying the limit operators method, we give a formula for the essential spectra of associated unbounded operators consisting of a union of the spectra of the limit operators defined by the potential q. We apply this formula and the spectral parameter power series (SPPS) method for the analysis of the essential spectral of Schrödinger operators with potentials q of the form , where is a periodic potential and is a slowly oscillating at infinity potential. The conjunction of both methods lead to an effective technique that can be used for performing numerical analysis as well. Several numerical examples demonstrate the effectiveness of our approach.


Operation conditions such as,anti corrosion air quantity,content of sulfur going into system and material proportioning have an effect on corrosion rate of equipment Also,corrosion may be aggravated due to wrong operation in blocking the urea converter (time,pressure)and the equipment operation with low load


Neuroinflammation is associated with a number of neurodegenerative diseases such as Alzheimer's disease. It is reported that lipopolysaccharide (LPS) can induce neuroinflammation and cognitive impairment. L-Theanine is non-protein amino acid obtained from tea leaves Camellia sinensis and it is identified to possess neuroprotective activity. The aim of this study was to explore the possibility of LTheanine in preventing LPS induced cognitive impairment. The study was carried out on Swiss albino mice in different groups by giving saline, L-Theanine (2mg/kg, 4mg/kg), LPS (0.25mg/kg) and Rivastigmine respectively. Various behavioral parameters and antioxidant assays were carried out. L-Theanine demonstrated antioxidant activity and significant increase in memory as evidenced by Y-maze spontaneous alteration test and Morris water maze test.


In this thesis, we propose a cooperative relay scheme for multihop communications in wireless sensor networks. The scheme investigates node cooperation in conjunction with power control to conserve transmission energy and improve communication reliability in the presence of fading. By using relay nodes that are located between transmitter and receiver to assist packet delivery, the scheme is capable of reaping both spatial diversity gains and pass-loss savings. Local channel information is explored in relay selection process and power control to reduce the energy of data packet transmission. Moreover, a cooperative ARQ is incorporated to improve packet retransmission efficiency. We analyzed packet delivery ratio and energy consumption, and observed good agreement between analytical and simulation results. In simulations, we compared different cooperative and non-cooperative schemes and examined effects of various factors. Our simulations and analyses show that the proposed scheme improves energy efficiency, packet delivery ratio and extends nodes' battery lifetime.


NOCARDIOSIS has a worldwide distribution and has been reported in various species of mammals, fish and birds (Beaman 1984, Bolon and others 1989, Megid and others 1990, Panigraphy and Senne 1991, Boiron and others 1993, Biberstein and Hirsh 1999, Chen and others 2000). Among birds, the disease has been observed in parrots, birds of prey, passeriformes, black crakes (Limnocorax flavirostra) and mynahs (Cooper 1973, Panigraphy and Senne 1991, Baumgartner and others 1994, Bacciarini and others 1999). The disease is of zoonotic importance, and it has been estimated that more than 1000 human cases of the disease are diagnosed each year in the USA (Schaal 1992). The frequency of nocardial diseases has increased over the past 20 years (Grange 2002). To the authors' knowledge there have been no reports of the occurrence and pathology of nocardiosis in pigeons. This short communication describes an outbreak of nocardiosis in domestic pigeons (Columba livia). Sixty-seven of 250 pigeons (26·8 per cent) 12 to 18 months of age died over a period of one year, singly or a few at a time, in a private pigeonry in Srinagar, in the Kashmir valley of India. The birds were reared for racing. The pigeons had also been procured from Delhi and from the Jammu region of Jammu and Kashmir state. They were maintained on grains of maize (Zea mays), bajra (Pennisetum typhoideum), wheat (Triticum sativum) and gram (Cicer arietinum), depending on their availability. The affected pigeons had lameness, drooping wings, depression, gasping and emaciation. External examination of the birds revealed yellowish nodules on the wing joints, humerus, radius, ulna, hock, tarsal and metatarsal joints, and on the skin. The nodules were sometimes enucleable, having a hard consistency. Removal of the skin of dead birds revealed the presence of nodules in the skin, mostly in the neck region. At postmortem examination, yellowish nodules were observed in the liver, lungs, air sacs, on the thoracic wall, pericardium and bones, with darkcentred, necrotic areas. Splenomegaly was additionally observed. Representative tissues from various organs, showing lesions were collected into 10 per cent formol saline; bones were processed after routine decalcification in formic acid-sodium citrate solution. Material collected from the liver, lungs and bone nodules was homogenised and cultured on blood agar plates containing 5 per cent sheep blood. These were incubated aerobically at 37°C for up to five to 10 days. Samples were also cultured on Sabouraud's dextrose agar. The characteristics of any colonies were noted, and the organisms were stained with Gram stain. After fixation, tissues were embedded in paraffin wax and 5 μm sections were cut and stained with Harris's haematoxylin and eosin (Luna 1968). Subsequently, sections were stained with Brown and Brenn Gram stain, the Ziehl-Neelsen and Fite methods for acid-fast organisms (Luna 1968) and the toludine blue-A rapid method (Humason 1979) for demonstrating mast cells. This was followed by the chrysoidin method (Harada 1957), fluorescent methods (Jagatic and Weiskopf 1966) and Unna's polychrome methylene blue method (Luna 1968) for mast cells, in order to compare the efficiency of the techniques. Sections were also stained by Gridley's method (Luna 1968) to rule out the role of any fungus in the disease process. On blood agar, the colonies appeared chalky whitish and were adherent to the agar surface; they were yellowishorange on Sabouraud's dextrose agar. The organisms were Gram-positive, non-motile, branching and filamentous, with a beaded appearance, and catalase positive. The organisms were identified as Nocardia species. Histopathologically, the nodules in the various organs were typically of granulomatous inflammation with a central necrotic core. This core was covered by an eosinophilic zone, which was surrounded by a layer of macrophages. The granuloma was encapsulated by fibroblasts infiltrated heavily with macrophages and lymphocytes. Langhans' giant cells were occasionally seen. The lesions showed the same pattern in the lungs, liver, bones, air sacs and skin. However, the fibrosis was more severe, and there were more giant cells, in the bones than in the other organs (Fig 1). Additional lesions in the liver included macrophage granulomas, hepatosis including granular and vacuolar degeneration, and congestion of the liver sinusoids. Severe congestion was seen in the lungs and the spleen, and the kidneys showed nephrosis and congestion. Ziehl-Neelsen stain did not demonstrate any acid-fast organisms except that the eosinophilic layer surrounding the necrotic core of the nodules was mildly acid-fast. Filamentous organisms were fully discernible with Gram stain, crowded at the periphery of the necrotic core of the granulomas (Fig 2). The organisms had a beaded appearance and were occasionally seen to divide at right angles. The organisms were also scattered around the lesions in the tissues and were clearly discernible by the Fite method, revealing their acid fastness (Fig 3). Coccobacillary forms were also seen around the granulomas in the parenchyma of the liver, lungs and in the bones. Morphologically, the organisms were indistinguishable from Nocardia species. Numerous mast cells in groups were noted towards the luminal surface of the parabronchi, the wall of the secondary bronchi and adjacent to the granulomatous lesions in the lungs. The mast cells reacted positively with all the histochemical methods used. No fungal hyphae could be demonstrated in the lesions. Nocardia species are aerobic, saprophytic actinomycetes present in most environments and can grow over a broad temperature range (Biberstein and Hirsh 1999, Grange 2002). The species Nocardia asteroides, Nocardia brasiliensis, Nocardia farcinica, Nocardia otitiscaviarum (syn Nocardia caviae), Nocardia transvalensis and Nocardia nova cause a variety of diseases in human beings and animals (McNeil and Brown 1994, Bani-Sadr and others 1995, Menendez and others 1997). Avian nocardiosis has been mostly associated with N asteroides (Cooper 1973, Baumgartner and others 1994). In the present study, the infection in the pigeons might have been acquired by inhalation, as the birds' digestive tract was not affected. This could be attributed to the very delicate and fragile nature of the organism, which makes it easily airborne (Braude and others 1982). The organisms might have disseminated from the primary site of multiplication in the lungs to the liver, bones, joints, pericardium and skin. FIG 1: Section of the humerus bone of a pigeon affected with nocardiosis, showing severe fibrosis around a granuloma. Haematoxylin and eosin. x 400


The present invention discloses a kind of hollow porcelain stick and its manufacture technology, as well as its application in producing the light fire-resistant stuff. Firstly shape the porcelain material to the pipe shape material by squeezing, then cut the pipe into some sections, and envelop the two ends to form the hollow porcelain material. After drying and firing, the hollow porcelain stick will be shape. In the course of producing the light fire-resistant stuff, add the hollow porcelain stick to the mixed material, therefore it can support and joint the whole fire-resistant stuff. Thetechnology can resist squeezing, breaking, vibrating.


The article by Johnston, Maguire, and Logan, in this month's issue, raises some interesting questions. The vitreal cavity no longer enjoys the privacy it had in earlier days as the more advanced techniques of surgery for detachment increasingly include an invasion of the vitreous with gases, fluids, and a variety of instruments. So far as gases are concerned, air with or without supplementary sulphur hexafluoride seems to be most commonly used. Whereas fluids, either balanced salt solution or silicone oil, may be considered largely as 'space fillers' after quantities of subretinal fluid have been removed, gas has a more specific function. It is said to 'tamponade the break,' though I would prefer the term to 'block up the hole.' Of course it is not really the gas that blocks up the hole; it is the surface-tension-generated skin around the bubble, which I suppose comes to more or less the same thing. On reading the aforementioned article I was rather uneasy about the explanation of the observed phenomenon: the apparent disturbance of previously flat holes elsewhere or, worse still, the production of holes in previously imperforate lattice elsewhere by means of a gas bubble to a superior position in the vitreal cavity. Consider case 1: a man had a superior detachment with a U tear but also three other tears in flat retina below. After drainage, 1 ml of SF6 gas was injected into the vitreous cavity. Later the three inferior tears came off, and it is recorded that 'the intravitreal gas bubble opened the inferior tears widely by increasing vitreoretinal traction when the patient was erect.' This conclusion nqeds fairly careful consideration. One might start by running through the sequence of events. Here was an eye with a superior detachment and subretinal fluid. The subretinal fluid was removed and the eye presumably collapsed to suit. Ocular volume was restored by an injection of gas 'into the vitreous body' before scleral buckling. If we assume that vitreoretinal bands were present, it is fair to say that directly or indirectly various parts of the retina would tend to be connected with one another via the bands. Thus, if initially (when the detachment occurred) a horseshoe tear is 'pulled down' by the vitreous and its bands, it stands to reason that if it is pushed up again with an air bubble the same bands will exert traction on the lower retina. In other words, it is not the air bubble that pulls the lower retina off: it is the upper retina that pulls it off via the vitreoretinal bands. It follows from this that if a large enough buckle is put in before the air injection the phenomenon should not occur, since upward movement of the superior retina at the site of the tear would be minimised. We may look at it another way and consider the bubble within the vitreous invested in its surfacetension-generated skin. Around the bubble the vitreous fibres are certainly stretched, hence exerting extra tension on the supplementary tears: all the more reason to buckle first. These may be worrying thoughts but in practice do they really matter? If results such as we are now used to seeing in papers by detachment experts, such as the 96% and 90% rates quoted in two selected references in Johnston, Maguire, and Logan's paper, are typical, then perhaps the problems are more theoretical than practical. However, the authors are certainly to be congratulated for bringing this hazard to our attention and possibly initiating work which might lead to even further refinements in retinal detachment technique.


Objectives: This study aimed to investigate the impact of high-fat diet and STZ induced diabetes as well as dapagliflozin treatment on hepatic protein expression of CYP3A4. Materials and Methods : In our study, 34 male Sprague-Dawley rats were randomly divided into four groups: control, high-fat diet and streptozotocin induced diabetes, dapagliflozin treated control and dapagliflozin treated diabetes. In the microsomes obtained from livers of these rats, the protein expression levels of CYP3A4 were determined by Western blot. Results: Hepatic CYP3A4 protein expression levels in control group treated with dapagliflozin were statistically significantly decreased compared to control group. Besides, hepatic CYP3A4 protein expression levels were decreased in dapagliflozin treated diabetic Sprague-Dawley rats compared to both control and diabetic group rats, but the difference between the groups was not statistically significant. Conclusion: According to these two results, the use of dapagliflozin resulted in inhibition of hepatic CYP3A4 protein expression.


Objective To investigated the application to control Longgang Street infectious diseases and value with prevention of migrant children vaccinated management.Methods To survey the vaccination of 1224 migrant children in 0-6 years in Longgang Street,compared with the incidence of infectious disease of migrant children to the incidence after the vaccination management.Results The incidence of infectious diseases was 6.5%,the rate of permittee was 75%,the rate of Vaccination(Six kinds of vaccines) was 87.73% in Longgang Street before migrant children vaccinated management.The incidence of infectious diseases was 6.5%,the rate of permittee was 75%,the rate of Vaccination(Six kinds of vaccines) was 87.73% in Longgang Street after migrant children vaccinated management.Conclusion The rate of permittee was increased.The implementation of migrant children to vaccination management plays an important role in the control of infectious diseases of Longgang Street.


Combined with the research achievements of lean concrete at home and abroad,the paper discussed its performance and mixture ratio design.


This article from to the GPS difference technology outline start, subsequently the OEM4-G2L board which produces by Canadian Novatel Corporation is an example, introduced the NMEA0183 agreement and its $GPGGA locate statement form, then the author showed by the detailed example based on the VC6.0 computer and the GPS receiver in difference position string mouth signal procedure.


For a discussion of freedom to begin with some reference to Kant is hardly surprising. Kant's work remains a standard reference for ethical or political philosophy and freedom is, as Kant puts it, the keystone to his whole system.' The appeal to Foucault is probably more unexpected. Positive references to freedom intervene only in Foucault's later texts and the most explicit discussions of the topic appear in articles or interviews more than in his major works. Not only is the concept less pervasive than in Kant's work, not only is the systematic role Kant grants it unimaginable for Foucault, but when Foucault does appeal to the idea of freedom he frequently reminds his readers that the sense he attributes to the concept must be at odds with the metaphysical concept. When Foucault does refer to freedom, he specifies that he is particularly at odds with the concept of freedom that he takes to be Kant's legacy. What then is to be learned by considering Kant and Foucault together on the subject of freedom? Let me start by pointing out that the two thinkers share a gesture in invoking freedom to describe the stakes of their critical analyses. Both of them invoke the possibility of freedom as that which gives a point to their work. Again Kant's claim is well known: the "point" of critical thinking is to fully exploit the possibility of self-realization and thus depends on there being freedom.2 The co-implication of the labor of reason and the progress of freedom is the very basis of the value of critical thinking. All this is quite familiar coming from Kant. Less obvious perhaps, is the fact that Foucault takes a similar position. It is implicit in the plea he makes at the end of his essay on the Enlightenment, for a continuation of critical work involving specific historical enquiries.3 It is made even more explicit when Foucault explains the motivations of his analyses. Although he explicitly rejects the Kantian dream of liberation through the exercise of reason, when pushed to explain what is to be gained from his own work, Foucault falls back on what he himself qualifies as an optimistic belief in freedom. I dwell on grasping the mechanisms of effective exercise of power; and I do so because those who are inserted in these power relations, those who are implicated in them, can, through their actions, through their existence or their rebellion, escape from these relations, transform these relations, in other words no longer be in a position of submission [bret; ne plus etre soumis].... From this point of view, all my research rests on a postulate of absolute optimism.4 The value of minute descriptions of mechanisms of power is here held to derive from the possibility that those who are implicated in these relations can "escape" or "transform" them. The analysis of specific situations is of interest because it reveals how certain transformations can change the rules of the game and how such changes can allow those implicated in those particular power relations no longer to simply submit to them. Such is the optimistic postulate that gives its point to Foucault's research. As another interview makes clear, this postulate is nothing other than a belief in human freedom: What I try to analyse are the practices, and the logic immanent to the practice, the strategies which bear out the logic of these practices and, therefore, the way in which individuals, freely, through their struggles, their confrontations, their projects, constitute themselves as subjects of their practices or, on the contrary, refuse the practices which are offered to them. I hold a solid belief in human freedom.5 To understand how individuals constitute themselves as subjects of their practices, or on the contrary refuse the practices offered to them, is then, according to Foucault, to understand how subjects exercise their freedom. To believe that subjects can refuse the practices offered to them is to hold a solid belief in human freedom. …


Objective:To investigate the effect of application of the process management theory in the disinfection supply office.Methods:The theory was applied in the management of disinfection supply office from Jan.2008 to Dec.2008.During the investigating,the process of nursing quality management included items recycle,washing,packaging,sterilization,delivering process and depositing process of sterilized items,and coordination between nurses from supply office and clinical departments.Results:The pass rate of equipments packaging was increased from 97% to 100%,the error rate of aseptic packages sending to clinical departments was reduced from 1% to 0%,and nurse degree of satisfaction was increased from 90% to 99%.Conclusion:Application of the process management theory in the disinfection supply office makes the management of the supply office scientific,normalized and systematic.The theory adapts to the clinical work and improves the nursing quality in the disinfection supply office.


Following its election victory, the Labour government embarked on a programme to reform fundamentally the United Kingdom's post-war welfare state. The reforms are outlined in a number of government policy consultation papers and are intended to address neo-liberal concerns about the welfare state, although neo-liberal panaceas have been rejected in favour of a "third way". Strongly influenced by Mead, Layard, Giddens and Field, the government's welfare reform package is premised on a conception of citizenship that emphasizes equally the importance of "entitlements" and "obligations", especially the obligation to work. We argue that this reform approach is inherently flawed: it presumes that the poor are without work because they lack appropriate incentives, not because they lack jobs that will lift and keep them out of poverty. We argue that the government's welfare reform strategy is contradictory: while it aims to ameliorate poverty, the emphasis on obligations and compulsion may have the effect of reinforcing existing economic and social divisions. In approaching the second millennium, there is a clear need for a robust interventionist approach to welfare which emphasizes the right to a satisfactory standard of living.


The purpose of this study was to understand how ballet experience in changes unmarried women''s daily life in the aspects of motivation, continuous participation, physical and mental status. For this purpose, the author observed and interviewed five women in D metropolitan city adult ballet classes. For the result, the first experience was psychological separation from stress. The second change was related to the body shape. This change caused an effort to maintain this positive status of the body. Last but not least, participants had positive ways of thinking to accommodate ballet as a ballet itself, not just exercise.


Kriging searches are routinely limited to optimize the smoothing for volume variance relations, decrease model reliance on stationarity and decrease the computational time required. The optimal kriging search depends on the type of estimate being made, from visualization to interim to final decisions. There are a number of kriging measures to help quantify the impact of a limited search on estimates including Krige's kriging efficiency and the slope of regression. In this paper, a new statistically based measure of kriging efficiency which compares the kriging variance to the global simple kriging variance is proposed. A number of cross validation case studies demonstrate that the lowest mean squared error for estimates can be obtained for kriging with large numbers of search data. This also increases the theoretical slope of regression and kriging efficiency.


Objective
To investigate effects of different working environment on the vigilance and attention of the ship crew.

Methods
The times of correct response of the ship crew at different posts to simultaneous sound-light reaction, progress in the sound-light reaction time, the time on targets and the time out of track of targets were detected by using attention distribution measuring instrument (EP707A) and attention focus measuring instrument (EP711).

Results
There were significant differences in attention focusing for the ship crew at different posts (F= 3.78, P= 0.006). Different working environment had significant effects on attention focusing of the ship crew with more than 3 years of service at sea.

Conclusions
The ship crew working in the electromechanical and ammunition departments had relatively poor attention focusing. Three to five years of service onboard the ship was an important episode, when attention focusing was affected or most likely to be affected.

Key words:
Naval ship crew; Attention focus; Attention distribution


Nitrogen (N) deposition has been increasing in alpine ecosystems, but its fate in soils and plants remains unclear. We assumed that the increased N load will be efficiently retained in alpine ecosystems but that the degree of N use efficiency changes with elevation. Thus, we performed a 3-year 15N tracer experiment, in which we added 1 g m−2 of either NH415NO3 or 15NH4NO3 fertilizer to a plot of 1 m2 in size at three elevations. Composite soil samples and aboveground plant material from lichens, dwarf shrubs, and graminoids were collected annually for three years and analyzed for their 15N accrual. We found a cumulative and plateauing rise in 15N concentration in soils and plants at all sites. However, overall recovery of the tracer decreased with time, amounting to 71% of fertilizer recovered in the soils in the first year, 69% recovered in soils and plants in the second year, and 37% in soils and plants in the third year. Moreover, the fertilizer use efficiency varied among fertilizer types and plant functional types. This utilization pattern appears to be modulated by elevation.


ABSTRACT The paper by Nold et al. [Phys. Fluids 26 (7), 072001 (2014)] examined density profiles and the micro-scale structure of an equilibrium three-phase (liquid–vapour–solid) contact line in the immediate vicinity of the wall using elements from the statistical mechanics of classical fluids, namely density-functional theory. The present research note, building on the above work, further contributes to our understanding of the nanoscale structure of a contact line by quantifying the strong dependence of the liquid–vapour density profile on the normal distance to the interface, when compared to the dependence on the vertical distance to the substrate. A recent study by Benet et al. [J. Phys. Chem. C 118 (38), 22079 (2014)] has shown that this could explain the emergence of a film-height-dependent surface tension close to the wall, with implications for the Frumkin–Derjaguin theory. GRAPHICAL ABSTRACT


The isoscalar giant dipole resonance (ISGDR) in 2csPb has been investigated using inelastic scattering of 200 MeV a particles at and near O" where the angular distrfbutiin of the ISGDR can be clearly differentiated from other modes. The "diierencs of spectra" technique was employed to separate the contribution from the high-energy octupole resonance (HEOR). Results from a preliminary analysis of the data are consistent with the expected positions of the ISGDR and HEOR, as well as their expected angular distributions near O". The isoscalar giant dipole resonance (ISGDR) is best described as a "hydrodynamical density oscillation", in which the volume of the nucleus remains constant and the state can be visualized in the form of a compression wave oscillating back and forth through the nucleus (the "squeezing mode") [l]. This is a second-order effect (in the first order, of course, the isoscalar dipole mode +Present address: KVI, 9747AA Gmningen, The Netherlands. *Present address: University of Tennessee, Department of Physics, Knoxville, TN 37966, U.S.A. Elsevier Science B.V. SSDI0375-9474(94)00034-K 326~ B.F. Davis et al. I Looking for the isoscalar giant dbole resonance in 208Pb corresponds merely to spurious center-of-mass motion) and in addition to being of substantial intrinsic interest as an exotic mode of collective oscillation, also has its importance in that it provides, like the monopole resonance (or "breathing mode"), a direct measurement of the nuclear incompressibility. The excitation energy of the ISGDR, as given by the scaling model [2] is:


On-line diagnosis must accommodate the existing sensoring capabilities of a system, which often results in limited diagnosability. However, although faults may not be always discriminable, there are generally operating modes of the system in which they are. Active diagnosis relies on applying specific inputs to the system so as to exhibit additional symptoms that help refining the diagnosis. The idea of this paper is to use the diagnosability properties to drive the system towards modes with increased diagnosability with respect of safety considerations. A new finite state machine called the active diagnoser is defined by abstracting continuous dynamics and taking into account controllability and safety constraints. The active diagnosis problem is then formulated as a conditional planning problem. Hence, the active diagnoser is transformed in an AND-OR graph and active diagnosis plans are computed by an appropriate graph exploration algorithm.


Energy efficiency measures in buildings are widely regarded as cost effective options to mitigate climate change. However, policy instruments are needed to improve the diffusion of such measures. T ...


The Planetary Boundary Layer (PBL) affects the pollutant dispersion process. Within the EpiAir Project (Air pollution and health: epidemiological surveillance and prevention) we performed a preliminary analysis to identify adverse (or opportune) situation for pollutant dispersion. Knowledge of the meteo-diffusive peculiarity of a city is an efficient support in identifying and planning preventive actions.


We study private inference control for aggregate queries, such as those provided by statistical databases or modern database languages, to a database in a way that satisfies privacy requirements and inference control requirements. For each query, the client learns the value of the function for that query if and only if the query passes a specified in- ference control rule. The server learns nothing about the queries, and the client learns nothing other than the query output for passing queries. We present general protocols for aggregate queries with private inference control.


Polybrominated diphenyl ethers (PBDEs) were measured in plastic resin pellets collected from 65 beaches across 27 countries worldwide. They were detected at 49 locations at concentrations of the sum of 49 congeners of up to 46 ng/g-pellet and a median of 2 ng/g-pellet. These values are one to two orders of magnitude lower than those of polychlorinated biphenyls (PCBs) (median, 51 ng/g-pellet). This difference can be attributed to lower production of the Penta-BDE technical mixture, which is Environmental Monitoring & Contaminants Research Japan Society for Environmental Chemistry This article is licensed under a Creative Commons [Attribution 4.0 International] license. © 2021 The Authors.


Continuous-time recurrent neural networks (RNNs) play an important part in practical applications. Recently, due to the ability of assuring the convergence of the equilibriums on the boundary line between stable and unstable, the study on the critical dynamics behaviors of RNNs has drawn especial attentions. In this paper, a new asymptotical stable theorem and two corollaries are presented for the unified RNNs, that is, the UPPAM RNNs. The analysis results given in this paper are under the generally -critical conditions, which improve substantially upon the existing relevant critical convergence and stability results, and most important, the compulsory requirement of diagonally nonlinear activation mapping in most recent researches is removed. As a result, the theory in this paper can be applied more generally.


Objective:To observe the clinical effect of realgar on multiple myeloma and to investigate the mechanism of its role.Method:MTT and Biantibody cramped ELISA assay were used to detect the activity of interleukin-6(IL-6) and level of soluble interleukin-6 receptor(sIL-6R) of the serum in 15 multiple myeloma patients with or without Realgar.Result:The activity of interleukin-6 and level of soluble interleukin-6 receptor of multiple myeloma patients were significantly higher than that of control group(P 0.01). They did not decrease apparently after realgar was used for 50 days(P 0.05).The interleukin-6 activity of stage Ⅲ patients were much higher than that of stage Ⅰ or Ⅱ patients(P 0.05). There was no difference of the level of soluble interleukin-6 Receptor between two groups(P 0.05). For 15 patients who used Realgar,3 attained CR, 5 attained PR.Conclusion:Realgar could not decrease the activity of interleukin-6 and the level of soluble interleukin-6 receptor so as to inhibit the proliferation of tumor cells.


The parts of poems in which the classical Turkish poets praise their own characteristics are called fahriye (praise). Fahriyes are usually found in the 'fahriye' sections of the odes. In addition, poets may allocate one or more couplets of their ghazals to fahriyes. The couplets written for the purpose of fahriye in the classical Turkish poetry are often the pseudonym couplets of ghazals. Abdulbaki Vecdi (d. 1661), who was one of the important representatives of the classical Turkish poetry of the 16th century, also frequently used tefahur (reflection) in the pseudonym couplets of his ghazals. In this article, how Vecdi used the fahriye in the divan was discussed and the understanding of fahriye was evaluated. This article includes an introduction, two main sections and a conclusion section. In the introduction, the history of the fahriye in classical Turkish poetry is briefly explained. In the first chapter, verse forms used by Vecdi while writing the fahriye are explained. In the second main section, fahriye couplets in Vecdi's ghazals are examined. The analogies and properties of these couplets have been determined. These couplets have been translated and explained according to modern Turkish. In the conclusion part, the main lines of Vecdi's conception of fahriye are stated.


Introduction:
 The trauma-induced coagulopathy is well-known pathophysiology of severely injured trauma patients. However, the difference due to the injury type is not well researched. The aim of this study is to investigate the difference of coagulopathy between the blunt and penetrating trauma. PATIENTS and

 Methods:
 Single-center retrospective study was conducted. The electrical record of patients admitted from April 2008 to March 2017 were reviewed and penetrating trauma patients with injury severity score (ISS) 9 or more were enrolled. The case-control matching with blunt trauma patients was performed, adjusting for ISS, Shock-Index, the need for transfusion, and lactate level at the hospital arrival. After the matching, 5 points of hemoglobin, fibrinogen, platelet, prothrombin-time percentage (PT%), fibrin/fibrinogen degradation products (FDP), and D-dimer in their clinical course were statistically compared.

 Results:
 8 patients were matched. FDP at hospital arrival was significantly higher in the blunt group compared to the penetrating group (Median 7.85 vs 92.8; p<0.01). Although there is no statistical significance, in the blunt group, D-dimer of the acute phase was much higher and PT% of the early phase was much lower than that of the penetrating group (refer the figures).

 Conclusion:
 In the acute and early phase of severe traumatic injury, the hyperfibrinolysis of blunt trauma can be significantly more severe than that of penetrating trauma.


The article analyzes multiparty coalition governments under authoritarian tutelage in Morocco and Algeria. While in Morocco multiparty coalition governments are just a means for the King to dress their windows, in Algeria they represent a new arena of power bargaining. In both cases, portfolio allocation follows the Gamson's law but cases of advantage for the formateur are also given. Nonetheless, the parties included in multiparty coalition governments are almost always regime-controlled ones, as is the case in Algeria, or encounter reserved domains constitutionally defined, as is the case in Morocco. Moreover, in both cases the democratic potential intrinsic to multiparty coalition governments is defused by preventing grassroots parties to access top-weighted ministerial portfolios and by envisaging a relevant role for non-party ministries. This renders cabinet positions hardly contestable and adds up to the durability of multiparty coalition governments while making them barely apt at channeling grassroots demands for political change.


This study aimed to investigate the availability of the requirements for applying the concept of social entrepreneurship in the branch of Taibah University in the Khyber region in Saudi Arabia. To achieve this aim of the study, three basic hypotheses were formulated and tested using preliminary data collected through the survey, Data was collected by a convenience sample, the sample of study consisted of (307) students and faculty members, Data analysis and hypothesis testing have been depended on use methods of a structural equation modelling, path analysis, and direct and indirect analysis by using the Bootstrap method, The study found a significant effect of the dimensions of social entrepreneurship in the application of the concept of social entrepreneurship in Taibah University branch, And the relative importance of the requirements for applying the concept of social entrepreneurship , it's arranged as follows: (innovation voluntary participation acceptance of risk Initiative) ,The importance of the requirements for applying the concept of social entrepreneurship in the branch of Taibah University varies according to gender, specialization and function with regard to the dimensions of (acceptance of risk and voluntary participation) while it does not differ with regard to the dimensions of Initiative and innovation. Corresponding author: Abdallah Abdallah Ahmed El-Tabal Email addresses for the corresponding author: email@example.com First submission received: 20th April 2020 Revised submission received: 12th May 2020 Accepted: 29th May 2020


Sex determination, the developmental process by which sexually dimorphic phenotypes are established, evolves fast. Evolutionary turnover in a sex determination pathway may occur via selection on alleles that are genetically linked to a new master sex determining locus on a newly formed proto‐sex chromosome. Species with polygenic sex determination, in which master regulatory genes are found on multiple different proto‐sex chromosomes, are informative models to study the evolution of sex determination and sex chromosomes. House flies are such a model system, with male determining loci possible on all six chromosomes and a female‐determiner on one of the chromosomes as well. The two most common male‐determining proto‐Y chromosomes form latitudinal clines on multiple continents, suggesting that temperature variation is an important selection pressure responsible for maintaining polygenic sex determination in this species. Temperature‐dependent fitness effects could be manifested through temperature‐dependent gene expression differences across proto‐Y chromosome genotypes. These gene expression differences may be the result of cis regulatory variants that affect the expression of genes on the proto‐sex chromosomes, or trans effects of the proto‐Y chromosomes on genes elswhere in the genome. We used RNA‐seq to identify genes whose expression depends on proto‐Y chromosome genotype and temperature in adult male house flies. We found no evidence for ecologically meaningful temperature‐dependent expression differences of sex determining genes between male genotypes, but we were probably not sampling an appropriate developmental time‐point to identify such effects. In contrast, we identified many other genes whose expression depends on the interaction between proto‐Y chromosome genotype and temperature, including genes that encode proteins involved in reproduction, metabolism, lifespan, stress response, and immunity. Notably, genes with genotype‐by‐temperature interactions on expression were not enriched on the proto‐sex chromosomes. Moreover, there was no evidence that temperature‐dependent expression is driven by chromosome‐wide cis‐regulatory divergence between the proto‐Y and proto‐X alleles. Therefore, if temperature‐dependent gene expression is responsible for differences in phenotypes and fitness of proto‐Y genotypes across house fly populations, these effects are driven by a small number of temperature‐dependent alleles on the proto‐Y chromosomes that may have trans effects on the expression of genes on other chromosomes.


Holographic projection that utilizes holography to record and reconstruct images to be projected is an attractive technique because it inherently requires no lenses, which could lead to the development of an ultra-small projector. In addition, holographic projection has unique functions that are difficult to perform on other projections: multi-projection that projects a multi-image on plural screens (which are also applicable on tilted screens) and projection on arbitrary surface screens; however, holographic projection has considerable problems: speckle noise, hologram calculation time and zoom without using a zoom lens. In this paper, we begin with basics of holographic projection (how to calculate holograms and reconstruct the projected images, and why we need a random phase), and then describe our latest results: the speckle reduction technique, which is referred to as random phase-free method; multi-projection, and real-time holographic projection with the random phase-free method. In addition, our holographic projection is capable of performing the zoom function without using a zoom lens, using a numerical method called scaled diffraction which can calculate diffraction at different sampling rates on a projected image and hologram.


Plasmonic nanoparticles (NPs) hold tremendous promise for catalyzing light-driven chemical reactions. The conventionally assumed detrimental absorption loss from plasmon damping can now be harvested to drive chemical transformations of the NP adsorbent, through the excitation and transfer of energetic "hot" carriers. The rate and selectivity of plasmonic photocatalysis are dependent on the characteristics of the incident light. By engineering the strength and wavelength of the light harvesting of a NP, it is possible to achieve more efficient and predictive photocatalysts. We report a plasmonic--photonic resonance hybridization strategy to substantially enhance hot electron generation at tunable, narrow-band wavelengths. By coupling the plasmon resonance of silver NPs to the guided mode resonance in a photonic crystal (PC) slab, the reaction rate of a hot-electron-driven reduction conversion is greatly accelerated. The mechanism is broadly compatible with NPs with manifold materials and shapes optimized for the targeted chemistry. The novel enhancement platform sheds light on rational design of high-performance plasmonic photocatalysts.


Philadelphia—Potential treatments for the management of dry age-related macular degeneration (AMD) are numerous, but so far, studies still are ongoing as to their therapeutic benefit, said David S. Boyer, MD, here at the Macula 2011 and Atlantic Coast Retina Club meeting of the Wills Eye Institute. These promising agents fall into several categories, including those that offer neuroprotection, reduction in byproduct accumulation, visual cycle modulation, and suppression of inflammation. "Currently, the only approved treatment of dry AMD is the use of vitamins based upon the results of the Age-Related Eye Disease Study (AREDS) that showed a reduction of both a loss of visual acuity and of progression of dry AMD," said Dr. Boyer, who is with Retina Vitreous Associates Medical Group, Los Angeles, and a clinical professor of ophthalmology, University of Southern California/Keck School of Medicine, Los Angeles. "Patients with geographic atrophy, however, did not seem to have a reduction in formation or progression."


Recent works by Ajtai and by Ajtai and Dwork bring to light the old (general) question of whether it is at all possible to base the security of cryptosystems on the assumption that P 6 = NP. We discuss this question and in particular review and extend a two-decade old result of Brassard regarding this question. Our conclusion is that the question remains open.


Veena D Pillai & V M Shinde* Analytical Laboratory, The Institute of Science, 15, Madam Cama Road, Bombay 400 032 Received 31 January i994; revised 2 July 1994, accepted 8 December 1994 A method is proposed for extractive spectrophotometric determination of copper(I1), cobalt(II) and nickel(II) using triftuoroacetylacetone (TF AA) in combination with pyridine (Py) as an extractant. The effects of pH and concentration of TF AA and pyridine on the extraction have been reported. Copper(lI), cobalt(II) and nicke\(U) give coloured complexes having maximum absorbances at 325,315 and 328 nm respectively. The method is precise and reproducible and has been used for the determination of copper(II), coba\t(II) and nickel(II) in environmental, pharmaceutical and alloy samples.


REASONS FOR PERFORMING STUDY
It has been suggested that many of the beneficial effects of corticosteroids are mediated through mitogen-activated protein kinase (MAPK) p38 inhibition.

OBJECTIVE
To investigate the efficacy of the MAPK p38 inhibitor compound MRL-EQ1 to either prevent (Phase 1) or treat (Phase 2) recurrent airway obstruction (RAO) in horses.

METHODS
MRL-EQ1 was administered i.v. at a dosage of 0.75-1.5 mg/kg bwt q. 12 h. In Phase 1, susceptible horses in clinical remission were divided into 2 groups (n = 5/group), based on historical values of respiratory mechanics. All horses were entered in the study in pairs (one control, one treated horse) and exposed to the same environmental challenge (stabling, mouldy hay and dusty conditions). The treatment group received MRL-EQ1 for 14 days while the control horses were untreated during the same period. In Phase 2, affected horses were ranked by severity of respiratory dysfunction and split randomly into either dexamethasone or MRL-EQ1 treatment groups (n = 5/group). Bronchoalveolar lavage fluid, respiratory mechanic measurements, MRL-EQ1 plasma concentration and tumour necrosis factor (TNF) whole blood activity were evaluated sequentially.

RESULTS
In Phase 1, MRL-EQ1 did not prevent the occurrence of clinical signs and pulmonary inflammation. However, treatment was associated with a reduction in severity and a delay in the onset of signs and a reduction in pulmonary neutrophilia. In Phase 2, plasma concentrations achieved resulted in ex vivo suppression of lipopolysaccharide-induced TNF production in equine blood. MRL-EQ1 did not improve airway inflammation or lung function and was associated in a dose dependent manner with behavioural (depression, excitability) and blood changes (neutrophilia, increased serum muscle enzyme concentrations).

CONCLUSIONS
Inhibition of p38 in the horse was partially effective in reducing clinical signs and airway inflammation when administered prior to, but not during clinical exacerbation in RAO.

POTENTIAL RELEVANCE
Inhibitors of p38 MAPK with a better toxicity profile may be effective in the prevention or treatment of RAO.


The high thermal conductive carbon sheet using mixed carbon of expanded graphite and carbon nanotubes is disclosed. High thermal conductive carbon sheet using mixed carbon of expanded graphite and carbon nanotubes of the present invention is mixed with a predetermined mixing ratio expanded graphite (Expanded Graphite) powder and carbon nanotube (CNT, Carbon Nano Tube) molded by hot pressing the powder, a unit carbon sheet layer; And a unit is formed on at least one surface of the carbon sheet layer reinforces the unit carbon sheet layer, characterized by including a synthetic resin layer to insulate the unit carbon sheet layer electrically. According to the present invention, I am improved in the horizontal direction and the thermal conductivity in the vertical direction as well as the physical properties can be relatively enhanced, and improved the tensile strength and tear strength. Carbon sheets, expanded graphite, carbon nano-tube, a powder, a film, a reinforcement


This article models the concentration of computer services activity across the U.S. with factors that incorporate spatial relationships. Specifically, we enhance the standard home-area study with an analysis that allows conditions in neighboring counties to affect the concentration of employment in the home county. We use county-level data for metropolitan areas between 1990 and 1997. To measure change in employment concentration, we use the change in location quotients for SIC 737, which captures employment concentration changes caused by both the number of firms and the scale of their activity relative to the national average. After controlling for local demand for computer services, our results support the importance of the presence of a qualified labor supply, interindustry linkages, proximity to a major airport, and spatial processes in explaining changes in computer services employment concentration, finding little support for the influence of cost factors. Our enhanced model reveals interjurisdictional relationships among these metro counties that could not be captured with standard estimates by state, metropolitan statistical area (MSA), or county. Using counties within MSAs, therefore, provides more general results than case studies but still allows measurement of local interactions.


The invention discloses wireless sensor network gateway equipment and a channel algorithm thereof. The equipment comprises a wireless sensor network coordinator module, a micro processor module, an Ethernet module, a wireless local area network (WLAN) module and a time division-synchronous code division multiple access (TD-SCDMA)/general packet radio service (GPRS)/global system for mobile (GSM) module, wherein the wireless sensor network gateway equipment performs data transmission and receiving on each node of a wireless sensor network through the wireless sensor network coordinator module, and is connected with the Internet through the Ethernet module or the WLAN module or is connected with a public wireless communication network through the TD-SCDMA/ GPRS/GSM module. Apart from the conventional wired connection modes, such as Ethernet, serial ports and the like, the equipment also supplies broadband wireless connection modes, such as Wlan, third-generation (3G) (TD-SCDMA) and the like, so that data forwarding requirements in different environments and different applications are met.


Summary Several antibiotic substances were found in the ether-soluble extract of the mycelium of various cultures of S. griseus, which differed in their chemical nature and antimicrobial activities. One of these fractions from S. griseus No. 3533, designated as streptocin, possesses strong trichomonadicidal properties. It is active against gram-positive bacteria. Small amounts of streptocin are also present in the culture filtrate of the organism. Streptocin is distinct from actidione in its physical and chemical properties and in the nature of its antimicrobial spectrum.


It is widely accepted that the two volumes of Luke-Acts are based on an inaugurated eschatological framework. The kingdom of Christ has already been established, but it is not yet present in its fullness. Given this framework of "already/not yet," how do we understand Jesus' promise to the Twelve in Luke 22:28–30 that they would "sit on thrones judging the twelve tribes of Israel?" If that is the promise, what does the fulfillment entail? Here we will examine Jesus' promise in Luke's Gospel and its fulfillment in the Book of Acts. The central proposal of this study is that the twelve apostles began to judge the twelve tribes of Israel in their inaugurated co-regency in the series of events following the ascension of Jesus and culminating in Pentecost.