Alzheimer's disease (AD) is a progressively debilitating neurodegenerative disorder characterized by the presence of proteinaceous deposits in the brain. AD often results in olfactory dysfunction and impaired olfactory perceptual acuity may be a potential biomarker for early diagnosis of AD. Until recently, there is no Alzheimer's nanoscope or any other high-end microscope developed to be capable of seeing buried feature of AD clearly. Modern neuroimaging techniques are more effective only after the occurrence of cognitive impairment. Therefore, early detection of Alzheimer's disease is critical in developing effective treatment of AD. H and E (Haematoxyline and Eosin) staining is performed for examining gross morphological changes, while TUNEL (transferase (TdT)-mediated dUTP nick end labeling) staining for monitoring neuronal death in the olfactory epithelium (OE). Furthermore, immunohistochemistry and western blot are performed to examine β-amyloid protein expression. AD model animals were Tg2576 (transgenic mice that overexpress a mutated form of the Aβ precursor protein), and 6 month (before onset of AD symptoms) and 14 month (after onset of AD symptoms) old WT (wild type) and transgenic mice were compared in their olfactory system. We found that in OE of Tg2576 mice, thickness and total number of cells were decreased, while the numbers of TUNEL-positive neurons, caspase-3 activation were significantly increased compared with age-matched WT. Our results demonstrate that the olfactory system may get deteriorated before onset of AD symptoms. Our findings imply that an olfactory biopsy could be served as an early and relatively simple diagnostic tool for potential AD patients.


The discussions that have occurred in history over the past one hundred years were always reflected on the pages of superheroes comic books (known as Comics, and here in Brazil called Gibi) - especially the question on the difference and gender. These comics were the first ones to bring this discussion to the means of mass communication. The woman has always had her role in the superheroes comics, at first performing a supporting role, being the object of the machinations of villains, and after some time, with the feminist movements and the movements for human rights, performing the main role, being the super heroine of the stories.


In recent years, various proprietary treatment technologies have evolved to reduce the polluting impact of urban run-off on receiving watercourses. The majority are 'flow-through' devices, designed to intercept and store pollutants in submerged chambers for later removal and safe disposal. Frequently, the performance of such systems is described solely in terms of 'ability to remove pollutants from the inflow', usually at specified discrete flowrates. However, it is suggested that this is insufficient to give a true assessment of performance and a critical parameter that is often overlooked is chamber 'retention efficiency', the ability of a chamber to retain stored pollutants once collected. In the current study, this parameter is investigated experimentally for a range of chamber configurations. Cylindrical chambers with different inlet orientations, internal components and hence flow dynamics are considered. The study identifies retention efficiency as being a major differentiator between designs, and concludes that chambers in which captured pollutants are stored in regions that are hydraulically isolated from the main treatment area are likely to be the most effective in practice.


An effective Hamiltonian is derived to describe the conduction band of monolayer black phosphorus (phosphorene) in the presence of spin-orbit coupling and external electric field. Envelope function approximation along with symmetry arguments are utilized to derive extrinsic spin-orbit splitting, which is shown to be linear in both the magnitude of the external electric field and the strength of the atomic spin-orbit coupling. The spin splitting is akin to the Bychkov-Rashba expression but demonstrates an in-plane anisotropy. The spin relaxation of conduction electrons is then calculated within the Dyakonov-Perel mechanism where momentum scattering randomizes the polarization of a spin ensemble. We show how the anisotropic Fermi contour and the anisotropic extrinsic spin splitting contribute to the anisotropy of spin-relaxation time. Scattering centers in the substrate are considered to be charged impurities with screened Coulomb potential. We report that spin ensembles with different initial polarization in the plane of phosphorene show an anisotropy of more than an order of magnitude in spin-relaxation time.


Safety is one of the important characteristic of the radar equipment,involving design,produce,use,management...etc.In this paper the fuzzy comprehensive evaluation method is used to generally evaluate radar equipment due to the multi-factors and uncertainty.The index system of radar safety is built based on the various factors,which affects equipment's safety.The fuzzy comprehensive evaluation model is established,using D-S evidence combination to determine the assignment of right weight of evaluation factors,to evaluate the safety of radar equipment.According to the result of evaluation,guide the safety design improvement of radar system.


1. Adenosine caused dose‐dependent action potential abbreviation in multicellular guinea‐pig atrial preparations, an action antagonized by glyburide (IC50, 31 microM) in both physiological and low‐chloride superfusate. 2. When 5 mM ATP was included in pipettes for whole‐cell voltage clamp of isolated guinea‐pig atrial myocytes, adenosine (10 microM) increased the holding current at ‐40 mV from 41 +/‐ 8 to 246 +/‐ 31 pA (mean +/‐ S.E.M., P < 0.01), and glyburide (20 microM) returned the holding current to 69 +/‐ 11 pA (P < 0.01 vs. adenosine alone). Acetylcholine (10 microM) also increased the holding current, but its effects were not altered by glyburide. 3. Both adenosine and acetylcholine induced an additional current component in response to 500 ms voltage steps. Glyburide partially inhibited the adenosine‐induced current, but did not alter the effect of acetylcholine. In the presence of maximally effective acetylcholine concentrations, adenosine increased membrane conductance (P < 0.01), although to a lesser extent than in the absence of acetylcholine. 4. Single K+ channel activity was seen in only one of eight cell‐attached patches in the absence of adenosine or acetylcholine (0.5 mM Ba2+ in bath and pipette solutions). With acetylcholine (10 microM) in the pipette, inwardly rectifying channels (conductance, 41 +/‐ 5 pS) were seen in five of six patches. With adenosine (10 microM) in the pipette, single‐channel activity was seen in twelve of fourteen patches with two populations of channels, one similar to that induced by acetylcholine and another higher‐conductance channel (72 +/‐ 5 pS) that showed less inward rectification. Glyburide (20 microM) suppressed the high‐conductance channel (68 +/‐ 2 pS) leaving a single channel type with a conductance of 36 +/‐ 5 pS and strong inward rectification. 5. We conclude that K+ATP channels contribute to the electrophysiological actions of adenosine on guinea‐pig atrium in the presence of physiological intracellular ATP levels, and may therefore play a role in the cardiac electrophysiological effects of adenosine in the absence of myocardial ischaemia.


Feature selection is a valid method to reduce the dimension of text vector in automatic text categorization system.Nave Bayes text classifier is a simple and effective text classification method. Proposes a new evaluation function named the dispersion of mutual information in feature selection and an improved text classification model based on Bayes theorem called Stump Network. Experimental results show this model has higher classification accuracy in most data sets.


This case study demonstrates the potential exacerbation of inflammatory bowel disease secondary to using isotretinoin (Roaccutane®) for treatment of severe acne.


A 44-year old man with grade 2 pulmonary sarcoma that infiltrated the pleura and a large pleural effusion, presented symptoms of dyspnea, cough, chest pain, and fatigue. The patient was referred to our ECHO lab for further evaluation. A complete two-dimensional echocardiographic examination was performed and a large solid mass was revealed inside the left atrium causing severe mitral valve obstruction during diastole (mean gradient 12 mmHg). Mass size was 45 9 67 mm and was protruding during diastole in the normal mitral valve (mitral valve area 3.5 cm). The origin of the mass was obscured due to its size. The left ventricular diameter slightly exceeded normal upper limits with normal ejection fraction and the left atrium was significantly dilated (55 mm). Pulmonary artery systolic pressure (PASP) was increased (Figs. 1 and 2, movie clips S1 and S2). Due to the large size of the mass and the infiltration of the pleura,


Background: Idiopathic Granulomatous Mastitis (IGM) is a chronic inflammatory disease of the breast. Although most of the studies have reported IGM as a rare disease, recent studies have shown an increase in the prevalence, especially in developing countries. The most important challenge is about the appropriate treatment of this disease that is not established yet. The aim of this cross-sectional study was to review the definite cases of IGM in terms of clinical characteristics and the result of treatment at Motamed Cancer Institute (MCI).
Methods and Materials: This retrospective study was conducted on 383 women who were referred to Motamed Cancer Research Institute with a confirmed diagnosis of IGM for a two-year period from March 2015 to February 2018. The demographic and clinical characteristics and the result of treatment options were extracted from the patients' medical records. The data was statistically analyzed using SPSS version 22.
Results: Among 383 pathologically proven cases with IGM, the mean age was 35.6+7.593 years, 97% of them had a history of pregnancy and 95.2% had breastfed. The most common symptoms of the disease were palpable mass, pain, fistula to the skin and inflammation respectively. In response to the prescribed treatments, among 241 patients with available follow-up, the most commonly used treatment was Corticosteroids + Methotrexate (70.1%), the highest complete remission was in the group receiving Corticosteroid (100%) and Methotrexate (97%) respectively and the highest partial remission belonged to Corticosteroid+ Methotrexate with the frequency of 21.3%. The shortest time to complete remission belonged to  Methotrexate regimen with a mean duration of 5.83 months and the highest recurrence rate was seen in the group receiving Corticosteroids alone (16.7%).
Conclusion: According to the results of this study, among the prescribed treatments, the highest rate of complete remission with the lowest duration and recurrence rate belongs to Methotrexate regimen. Corticosteroids were associated with the high rate of complete remission but high rate of recurrence yet. Given the autoimmune nature of IGM, such results seem expectable and Methotrexate could be recommended especially in moderate to severe forms and as an additional treatment to taper Corticosteroids. Implementation of clinical trials regarding the best treatment options for IGM is recommended.


This paper describes a 10-bit, 10-Msamples/s CMOS folding and interpolating analog-to-digital converter (F&I ADC). A new cascading architecture is proposed to reduce the number of comparators and power consumption, and to increase input signal bandwidth. To reduce the nonlinear errors in the sample-and-holder (S/H), a charge-pump circuit is used. By using a wide range error correction scheme, the relaxed design of comparators is possible. The ADC was designed using a 0.25 /spl mu/m 1-poly 5-metal CMOS process. It consumes 62 mW at 40 Msamples/s. The INL/DNL is less than 0.5 LSB/0.4 LSB by MATLAB presimulation.


Purpose: To evaluate the 1-year clinical outcome of subsequent trabeculectomy following 25-gauge transconjunctival sutureless vitrectomy in refractory glaucoma with vitreous filling of the anterior chamber. Methods: This study was a retrospective and consecutive case series study. We reviewed the medical records of pseudophakic and aphakic glaucoma patients with vitreous filling of the anterior chamber who underwent subsequent trabeculectomy with mitomycin C (MMC), following 25-gauge transconjunctival sutureless vitrectomy. All patients had been followed up for more than 12 months. Complete surgical success was defined as an intraocular pressure (IOP) ≤18 mmHg and IOP reduction ≥20% without glaucoma medication. Qualified surgical success was defined as IOP ≤18 mmHg and an IOP reduction ≥20% with or without glaucoma medication. Results: Eight eyes of seven patients (four eyes of four patients with pseudophakic glaucoma and four eyes of three patients with aphakic glaucoma) were included in this study. The cumulative probability of qualified success was 87.5%, and the cumulative probability of complete success was 62.5% at 12 months after trabeculectomy. The mean IOP decreased from 28.1 ± 3.5 mmHg preoperatively to 15.0 ± 3.7 mmHg at the final visit (p = 0.012). The mean number of glaucoma medications decreased from 4 ± 0 to 1.5 ± 2.1 at the final visit (p = 0.010). Complications including retinal detachment, vitreous hemorrhage, cystoid macular edema, and vitreous incarceration into the fistula were not observed. Conclusions: Transconjunctival sutureless vitrectomy and subsequent trabeculectomy with MMC is an effective method for controlling IOP in pseudophakic and aphakic glaucoma with vitreous filling of the anterior chamber. J Korean Ophthalmol Soc 2021;62(3):379-388


Background: Despite evidence of benefit on morbidity and mortality, cardiac rehabilitation (CR) remains underutilized. Studies have identified multiple reasons for lack of participation, but few have addressed racial disparities that may exist. Methods: A database of patients referred to CR between May 2001 and January 2011 was constructed. Data on gender, race, age, specialty of referring physician, co-payment, reason for referral, and attendance were collected. Racial groups were classified as Caucasian or minorities (African American, Hispanic, Asian, Pacific Islander, and multi-racial). Reasons for referral included acute MI, CAD, stable angina, CHF, and valvular heart disease. Data was analyzed using a Chi-square test to compare the initiation and non-initiation groups. A multivariate logistic regression estimated the odds ratio of variables predicting CR initiation. Results: Of the 822 patients referred to CR, 488 (59.4%) initiated CR and 334 (40.6%) did not. There was no difference in age (61.6 vs. 61.6, p = 0.987) or gender distribution (36.9% vs. 41.6% females, p = 0.161) between groups. Furthermore, need for co-payment (p = 0.091), reason for referral (p = 0.490), and whether the referring physician was a specialist or primary care physician (p = 0.740) did not affect attendance. Overall, minorities initiated CR less often than Caucasians (34.8% vs. 45.6%, p = 0.003). Based on the logistic regression analysis, Caucasians were 78% more likely to initiate CR (OR 1.78; 95% CI 1.13-2.80). Older age was a negative predictor of CR initiation, with each year of age decreasing likelihood of initiation by 2% (OR 0.98; 95% CI 0.96-1.00). Conclusions: Racial disparity exists amongst CR participants, with a clear under-representation of minorities in our urban medical center. Gender, physician referral patterns, and need for co-payment did not influence participation. Further investigation is required to determine why such disparity exists.


Recent research in the field of free radical biology suggested an important pathophysiological role of free radicals and oxidative stress in the development and progression of liver diseases. In light of the fact that modern medicine still lacks the reliable liver-protective drug, the plant-derived natural products with prominent antioxidant properties are gaining increased importance in search for new and effective therapies. Micromeria croatica (Pers.) Schott (Lamiaceae) is an aromatic perennial dwarf shrub and endemic species of Croatia that was previously reported to possess considerable antioxidant abilities, mainly attributed to the high level of polyphenolic substances.1 The aim of this study was to investigate the hepatoprotective effect of Micromeria croatica ethanolic extract (MC) using an animal model of carbon tetrachloride (CCl4)-induced liver injury in mice as well as to elucidate the underlying mechanisms of its activity.2 MC was administered by oral gavage at doses of 50, 200 and 400 mg/kg, once daily for 2 consecutive days, 6 h after intraperitoneal CCl4 injection. CCl4 intoxication resulted in liver damage and oxidative stress as evidenced by increased serum alanine aminotransferase (ALT) activity and decreased Cu/Zn superoxide dismutase (SOD) activity as well as increased 4-hydroxynonenal (4-HNE) formation. CCl4 administration also triggered inflammatory response in mice livers by activating nuclear factor-kappaB (NF-κB), which coincided with the induction of tumor necrosis factor-α (TNF-α). MC treatment decreased ALT activity and prevented liver necrosis. Improved hepatic antioxidant status was evident by increased Cu/Zn SOD activity and decreased 4-HNE formation in the livers. Concomitantly, nuclear factor erythroid 2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1) were overexpressed. The hepatoprotective activity of MC was accompanied by the increase in NF-κB activation and TNF-α expression, indicating amelioration of hepatic inflammation. Additionally, MC prevented tumor growth factor-β1 (TGF-β1) and α-smooth muscle actin (α-SMA) expression, suggesting suppression of fibrogenesis. These results demonstrated for the first time that MC possesses in vivo antioxidant, anti-inflammatory and antifibrotic activities, which are comparable to those of standard hepatoprotective drug silymarin, and may be beneficial against liver diseases


Measurements have been performed of the nuclear-magnetic-resonance longitudinal and transverse relaxation and the self-diffusion coefficient of deionized water confined in the porous space of a silica glass. The average pore diameter of the glass is 3.5 nm, and the experiments were conducted with different degrees of fluid filling. All three physical quantities were found to be linearly dependent on filling provided this was in excess of the amount of water corresponding to one monolayer, in agreement with theoretical predictions based on geometrical considerations. However, a deviation is observed below one monolayer, which is interpreted as a modification of the liquid-solid interface interaction, which causes the water molecules to become less mobile.


In this paper we report studies on the influence of silver island films' thickness on their optical and surface-enhanced Raman scattering properties. The semicontinuous silver films of thickness in range 3-10 nm were fabricated using electron beam physical vapour deposition and their optical properties were characterized using UV-Vis-NIR spectroscopy. The SERS enhancement properties of fabricated films were evaluated using p-mercaptoaniline as an testing analyte. It was found that with increasing thickness of the silver films their plasmon resonance becomes broader and its maximum shifts toward longer wavelengths. The largest SERS signal enhancement was observed for the 7 nm thick Ag films.


Mg-Al-Ca alloys are well-known for their excellent creep resistance at elevated temperatures (≤ 200 °C). In the present study, the deformation behaviour of an Mg-3.68Al-3.8Ca alloy containing a network composed of an α-Mg phase matrix and an intragranular eutectic Laves phase network was studied within the temperature range of 20-170 °C using (instrumented) indentation at constant and variable strain rate including creep (relaxation) tests in combination with SEM, TEM and AFM. The geometry of the deformation zone around and below microindents was found to be orientation-dependent and influenced by the presence of Laves phases. The Laves phase was found to exhibit slip lines at intersections with slip lines and twins in the α-Mg phase. In addition to basal slip, non-basal slip was also observed in the α-Mg matrix (especially at α-Mg/Laves phase interfaces) along with basal slip in the Laves phase as confirmed by post-mortem TEM. The strain rate sensitivity, m, of the softer α-Mg phase and the interfaces was observed to increase with temperature. The nanoindentation creep tests showed that the creep properties of the Mg2Ca Laves phase are much better than those of the α-Mg phase. However, creep tests on interfaces indicated deformation by interfacial sliding and revealed creep properties similar to those of the α-Mg phase.


Jane Bainbridge, freelance writer and mother gives a consumer's view on the issues facing maternity services. This week she looks at domestic violence during pregnancy.


Resintez of kinds showed the method of genetic analysis, that many of tetraploid types of wheats it is impossible to examine as independent taxonomical units. On the basis of genetic analysis it offers to plug in the group of tetraploidea only four kinds: T.dicoccoides Korn., T.timopheevii Zhuk., T.araraticum Jakubz., T.dicoccum Shubl. All other kinds (durum, turgidum, persicum, polonicum, aethiopicum) behave to the natural ecology- geographical categories.


This paper presents the computation of two limits for the nonlinear gain of the error- squared controller considering two procedures and performance analysis so that a closed-loop system with this control algorithm is asymptotically stable in the Lyapunov sense. The first limit for the nonlinear gain is obtained using Lyapunov stability theorem. The second limit for the nonlinear gain is obtained computing a limit for a linear gain and then the procedure is generalized to the nonlinear case. Simulation results were made comparing the tuning methods proposed in this paper, for the error-squared controller, with other tuning conventional methods found in the literature. It shown that the limit computed from second method is more conservative.


A shift in mind‐set is required to appreciate the extent of change demanded at a global level to begin to reverse ideological and exploitative processes that by continuing to polarize the world into a small and shrinking rich core and a large and growing poor periphery threaten the lives of all in an interdependent world. Proposals for reversing such adverse processes include (i) acquiring a deeper understanding of the 'Third World' or 'periphery' as a problem in which all nations are deeply implicated, (ii) fostering greater support for peace movements, and (iii) propagating new ways of thinking about progress. The dramatic political transition in South Africa illustrates how war can be avoided through peaceful negotiations. Successful ongoing social transformation in South Africa will depend, at least in part, on other countries emulating South Africa's example in different, but analogous, contexts.


Let Σ and Γ be two vector alphabets consisting of alphabetic vectors (a 1 , a 2 ), where a 1 , a 2 ∈ A ∪ {E} for an alphabet A. We show that it is decidable whether or not Σ ⊗ ∩ Γ ⊗ is the trivial submonoid of the direct product A* × A* for the generated submonoids Σ ⊗ and Γ ⊗ . On the other hand we show that a simple version, obtained from letter-to-letter homomorphisms, of the modified Post Correspondence Problem is undeciduable for alphabetic vectors


i Organ donation is the most cost-effective, if not the only, option for the treatment for end-stage organ failure. End-stage organ failure is an epidemic, costing the Canadian healthcare system over $35 billion dollars per year. As organ donation and transplantation (ODT) is the most cost-effective solution, it is in Canada's best interest to maximize the number of donors to allow for the maximum number of transplants. Canada currently lags behind most developed countries and the literature describes most of the world being in an "organ shortage", with demand for transplants far exceeding the supply of viable, donated organs. Current efforts are improving donation rates, but not at the same magnitude that demand is increasing. Other jurisdictions use different operating principles to guide their ODT systems and achieve better results. Canada operates under a requested consent operating principle, where donors are required to volunteer their organs to be considered for transplantation. Many nations in Western Europe operate under a presumed consent operating principle, which reverses the onus and assumes everyone is a willing donor and individuals must specify their desire to not be considered. New and innovative operating principles have also been put into practice around the world. Israel operates under a reciprocal altruism operating principle where individuals who are willing donors, or are first-degree relatives of willing donors, are given priority ranking on the waiting list if they are ever awaiting a transplant. Iran operates under a legitimate market-based operating principle, allowing individuals to sell their kidneys (legalizing the clandestine practices that currently occur worldwide).


Study of sound made by marine species aid in ambient noise studies and characterization. This letter presents the work carried out on measurement of sound made by lobsters in a controlled environment and the data processing and the spectral analysis to identify the frequency contents. Lobsters collected in the shallow waters as well as deep waters in the ocean have been used for the sound measurement. The Panulirus Homarus and Palinustur Waguersis species were kept in a tank in a laboratory and measurements were made. Their fundamental frequencies, harmonics, and peaks are analyzed in the band 3 to 100 kHz under different conditions such as molting and nonmolting states. Analysis with respect to diurnal variations is also carried out. The results show that lobsters produce sound like musical instruments, which agree with the observations of Patek [Nature (London) 411, 153–154 (2001)].


Background In 2009 the Australian Road Rules were modified to specify use of age-appropriate restraints for children up to 7 years. Implementation of the new laws was expected to increase optimal restraint use, but international studies have reported little or no effect of legislation in low income and minority groups. Aims/Objectives/Purpose To compare restraint practices in children aged 2–5 years in low socioeconomic areas of NSW before and after introduction of legislation specifying age-appropriate restraint use. Methods Direct observations of children aged 2–5 years at sites within low socioeconomic areas were used to assess restraint practices. A pre-legislation sample was drawn from a 2008 cross-sectional observation survey (n=106) and post-legislation data were collected in 2010 from control sites in a cluster randomised trial (n=360). Logistic regression was used to compare restraint practices adjusting for variations in demographic distributions between the samples. Results/Outcome Age-appropriate restraint use increased from 41% to 73%, and correct use from 34% to 47% in the post-legislation sample. After controlling for child's age, parental education, income and language spoken at home, the odds of children in the post-legislation sample being appropriately restrained were 2.2 times greater (95% CI 1.4 to 3.6) and the odds of them being correctly restrained were 1.6 times greater (95% CI 1.0 to 2.7) than children in the pre-legislation sample. Significance/Contribution to the Field While there appears to have been an improvement in child restraint practices in low income populations following implementation of laws mandating age-appropriate restraint, the results indicate a need for further interventions to increase the number of children optimally restrained.


In the article the challenges of global and national scale to higher professional education system in Russia
are discussed as well as the necessity of higher professional education system modernization and adaptation
to global requirements of todays world, new requirements to strategic planning of technical university
activities are observed. Questions of strategic planning for modern technical university are viewed with
considerations based on National research Tomsk polytechnic university experience through TPU concept of
development and the main points of TPU integrated program of strategic development for the period of
2011-2015.


With the rapid development of reform and opening up,FDI and international trade in Jiangsu have achieved leap- forward development. Jiangsu has become an important area for attracting foreign investment and its total trade number continues to rise. By using 1995- 2012 data combined with econometric model,we find high relationship between FDI and trade. There is a long- term stable equilibrium relationship between the two.FDI has led an increase in total import- export trade number,optimized the structure of goods and trade industry,and prompted the upgrading of trade industry technology in Jiangsu.


This text analyzed the reasons of these familiar problems when cement is used to stabilize macadam foundation,such as cracks,eduction and smoothness mistakes,and this text will also give some prevention measures to make sure of the normal work of cement's stabilizing detritus grass roots.


Reactive power sensitivities are used to allocate optimal reactive power compensation for light load operation. Both locations as well as reactor values are determined. The proposed optimisation algorithm determines the effective location by dropping the ineffective locations during the optimisation process, taken into consideration system constraints.


While the promotion of reducing tariff by WTO,antidumping is widely used as an important trade policy to protect domestic industry.In this paper we use cournot model to analyse why antidumping is so popular in nowadays'inter- national trade.We also find that the more substitute a good is the easier it will be antidumped.We advice our importers should improve the differenciation of their goods so as to reduce the influence of other country's antidumping policy.


I finally figured out how to do a collapsible nav on my website: https://jgregorymcverry.com/ I was trying to do this with just CSS Grid


Objective To determine the potential importance of immune mechanisms in initiating neuronal injury, we assayed the method for extracting the PD IgG against substantia nigra membrane proteins and explored the ability of IgG to neuronal injury in vivo. Methods By differential centrifugation extracting the rat substantia nigra membranes and coupling it to CNBr activated-sepharose 4B, the twenty PD patients sera were applied to the column, and the elution was applied to the protein A-sepharose 4B, and then be collected. ELISA and SDS-PAGE were used to detect the specific combination activity of elution to membranes and the purity. The 24 SD rats were divided into three groups(8 per set)—PBS, normal IgG and PD IgG. Each was injected into the lateral SNpc, and the counts of TH positive cells were examined by immunohistochemistry. Results SDS-PAGE demonstrated the elution from CNBr activitied-sepharose 4B had four bands, and through the protein A column the elution turned out two distinct bands, 25 kd and 50 kd. The two bands accorded with the theory value of the relative molecular masses of IgG light chains and heavy chains. The extracted IgG was proved to be having antigen-conjuncted activity and also reached to electrophoresis purity. Four weeks following injection, a 51% decrease in TH cellular profiles was noted on the injected sides compared with the contralateral sides of the same animals. Similarly applied normal control IgG caused only a 4% decrease. PBS didn't show apparent changes. A significant difference (P0.05)in the quantity test was found between PD IgG and normal control IgG, so did PD IgG and PBS. Conclusion The results of the study showed that immunoaffinity chromatography could be used to extract the immunoglobulins against rat SN membranes involved in the PD patients sera, which could initiate the immune destruction of SN neurons in vivo.


Measurements of the dependence on incident proton energy of the analyzing power A/sub y/(theta) for p..pi../sup -/ production on nuclei are reported for the /sup 9/Be(p,..pi../sup -/)/sup 10/C reaction leading to the ground state (g.s.) and the first three excited states of /sup 10/C. For the transition to the g.s. the analyzing power shows little dependnece on proton energy while for transitions leading to the /sup 10/C(/sub 3.35/ and /sup 10/C(/sub 6.60/ states it varies considerably with incident proton energy. Nuclear structure dependence of the A/sub y/(theta) is also observed for the first time in p..pi../sup -/ reactions.


Perovskite La0.67−xLi3xTiO3 with x = 0.10, 0.11, 0.12 and 0.13 were firstly annealed at 800 oC then treated by reactive milling, followed by post-annealing at temperatures from 1100 to 1200oC. The crystalline structure of grain and grain-boundary were characterized by XRD and SEM. The impedance measurements showed that nanocrystalline La0.67−xLi3xTiO3 after being annealed at 1150 oC possessed a grain conductivity as high as 1.3 × 10 S.cm. The grainboundary conductivity was enhanced one order in magnitude after annealing at temperature higher 1100 C̊ and consists of 5.8 × 10 S.cm. The results have also showed the limitation of the adiabatic thermal treatment for the improvement of the grain-boundary conductivity and suggested the way to overcome the limitation by rapidly cooling the samples from the high temperature to


The progressive approaches to citizens' exercise of their right to an education, as proclaimed in the Constitution of the Russian Federation and developed in legislative acts, have become the defining prerequisites of the democratization of the system of education in Russia. Thanks to them it has become possible to emancipate professional-pedagogical activity, and the necessary legal conditions have been created for the differentiation of educational institutions in accordance with the inclinations, abilities, and needs of the population. However, signs of dissension and disarray have also appeared.


Thank you for downloading adapting the united nations to a postmodern era lessons learned. As you may know, people have look numerous times for their favorite readings like this adapting the united nations to a postmodern era lessons learned, but end up in harmful downloads. Rather than enjoying a good book with a cup of tea in the afternoon, instead they are facing with some malicious bugs inside their desktop computer.


Successful adaptation to air-breathing after intrauterine life calls for unimpaired lung differentiation and growth, completion of airway branching, adequate and anatomically competent transpulmonary blood circulation and adequate interstitial lymph drainage. The lungs must also be able to produce surface active agent and undergo a permanent switching of the airway epithelium from net fluid secretion to net absorption. Failure of these processes may lead to rapid neonatal demise because of lung hypoplasia (like Potter's syndrome), respiratory distress syndrome (RDS), alveolar-capillary dysplasia and cystic fibrosis (1–4). Later, alveolar flooding and severe gas exchange problems may be aggravated by ARDS, high-altitude lung oedema and cardiogenic lung oedema (5). During postnatal adaptation, the foetal lung epithelium needs to cease fluid secretion and switch to an organ that is able to remove excess liquid from lung lumen and maintain a proper layer of fluid lining the epithelial cells. The mechanisms behind the lung liquid removal at birth have been under intensive investigation. The process begins antenatally and is dependent on thyroid, glucocorticoid and catecholamine hormones (3,6). However, removal of fluid at birth also seems to make use of external squeeze, respiratory movements and interstitial oncotic forces (3,4,7–9). After birth, the fluid fluxes maintaining the thin airway epithelial liquid lining lean on epithelial ion transport. This is done by activating apical (i.e. luminal side) epithelial Na+ channels (ENaC) resulting in a vectorial movement of Na+ into the epithelial cell followed by extrusion by Na,K-ATPase to the basolateral direction (10). Water will follow passively along this osmotic gradient using paracellular (aquaporins, AQP) and transcellular pathways. One of the epithelial Na+ channels, ENaC, has been cloned and consists of at least three homologous subunits (a heterotetramer of a-, b-, cor d-ENaC) the mRNAs of which are ontogenetically regulated (4,10,11). A recent investigation has demonstrated that inactivation of a-ENaC gene function by short fragments of complementary RNA profoundly attenuates lung liquid absorption in rats, which is consistent with an earlier observation where a loss-of-function mutation of a-ENaC caused a severe respiratory distress and death of the newborn mice (12,13). Of pharmacological agents that regulate this Na+ channel, glucocorticoid hormone induces ENaC genes and extends the channel's retention within the plasma membrane, catecholamines have an influence on the open probability of the channel and the antihypertensive agent amiloride acts as an ENaC blocker (6,10,14,15). Of the environmental factors, alveolar hypoxia (as often associated with ARDS) downregulates both ENaC and Na,K-ATPase and its prolongation results in increased degradation of Na,K-ATPase protein (5,16). Another practical example of the relevance of hypoxia is mountain sickness with highaltitude-induced lung oedema that is associated with defective Na+ transport and can be treated with beta-sympathomimetic agents and glucocorticoid hormones (17). In fact, hypoxia may be able to reverse an actively Na+ transporting epithelium towards a phenotype more characteristic of foetal oxygen concentrations (18,19). Recent data suggest that the high pressure lung oedema fluid induced by experimental heart failure is able to enhance alveolar fluid resorption by inducing transepithelial Na-transport (20). The respiratory distress syndrome of the newborn premature (RDS) and term (TTN) infant is the most important direct cause of neonatal hypoxemia, morbidity and death (3). Presently, RDS in considered as caused by deficient surfactant production of the type II epithelial cells and inadequate removal of fluid from the luminal space because of defective ENaC (11). Now the RDS can, in many instances, be prevented by transplacental GC therapy, probably by increasing surfactant synthesis and, as supported by our Invited commentary for Li Y et al. Expression of water and ion transporters in tracheal aspirates from neonates with respiratory distress. Acta Pædiatrica ISSN 0803–5253


Goodarzi G.R., Payam Noor V., Ahmadloo F. (2017): Effects of nanoparticle treatments on propagation of Prunus mahaleb L. by seed. J. For. Sci., 63: 408–416. We examined the effects of nanoparticles (NPs) of TiO2 and ZnO at 0.5, 1, 2 or 3% concentrations for 10, 20, and 30 min in stratified seeds of Prunus mahaleb Linnaeus. Then, seedlings produced were irrigated to field capacity with NP solutions at control, 1, 5, and 10% concentration for 7 months in the greenhouse conditions. Treating seeds at 1% concentrations of TiO2-NPs for 20 min resulted in the highest germination percentage (65%) and at concentrations of 3% for 30 min it showed the lowest germination percentage (13%). The highest total seedling height was obtained after exposure of seeds to 0.5% TiO2-NPs for 10 min. Irrigation of seedlings with TiO2-NPs at the concentration of 1% seems to be a suitable method how to increase their total height, survival, and total dry weight. A decrease in the relative water content and an increase in proline were observed in response to the application of high levels of NPs.


In a study of the ultrastructure of tumors induced in mice by adenovirus 12, no intranuclear adenovirus particles could be found. In some nuclei, however, there were inclusions resembling those observed during the lytic cycles of adenovirus 12. There was an abundance of intracytoplasmic particles of type A and type C. Deposits of a very dense substance were found along the external surface of the cell membranes and also in the neighborhood of the C particles.


e21514 Background: To evaluate the efficacy and safety for the treatment of advanced soft tissue sarcoma with recombinant human adenovirus p53 (rAd-p53, Gendicine) injection and radiotherapy. Methods: From October 1, 2001, to May 1, 2013, 37 advanced soft tissue sarcoma patients have been treated with rAd-p53 plus radiotherapy. Gene therapy: multipoint injection of rAd-p53 within the neoplasm was given to head and neck as well as abdominal and pelvic tumor by ultrasound guided and to pulmonary metastatic lesion by CT guided. rAd-p53 was injected or perfused 1 × 1012 VP / 2 ml once a week for 3-16 weeks, and the average was 7 ± 2 weeks. Radiotherapy: radiotherapy was delivered 48-72 hours after the first rAd-p53 perfusion to a cumulative dose of 16-70 Gy / 8-35 fractioins / 2-7 weeks (average dose, 52.0 ± 5.0 Gy). Results: The rates of CR, PR, SD accounted for 8.1% (3/37), 43.2% (16/37) and 48.6% (18/37), respectively. All 18 patients of SD achieved the purpose of relieving pain and reducing local symptoms...


Abstract : The problem of scattering of plane waves at oblique incidence on a dielectric coated conducting circular cylinder is studied. The eigenfunction series solution is developed from the boundary conditions where it becomes necessary to introduce a coupled part of the field. The eigenfunction series solution is then changed into a residue series solution for the shadow region via Watson's Transformation. Since the residue series solution is valid only in the shadow region, the physical optics approximation was evaluated asymptotically to obtain the geometrical optics solution in the lit region. Combining the residue series and the geometrical optics solution yields a solution compatible with the Geometric Theory Diffraction (GTD). In carrying out Watson's Transformation it is seen that the coupled field is still present in the residue series solution while the geometrical optics solution remains uncoupled in the lit region.


For the application of photodynamic therapy and diagnosis many different photosensitizers have been developed. It is important to compare these photosensitizers for their activity. It is generally accepted that the most important mechanism of cell killing is via the production of singlet oxygen. We therefore performed basic studies to detect singlet oxygen using a luminol reaction. The relative singlet oxygen yields from 4 photosensitizers (Photofrin, ATX-S10, mTHPC and NPe6) were measured by the detection of luminol chemiluminescence at 445 nm wavelength in Menzel's buffer solution at pH 10.5. NPe6, ATX-S10 and mTHPC all showed singlet oxygen productive abilities. These photosensitizers are new promising photosensitizers. These results show a possibility of comparison of each photosensitizer.


In order to improve enterprises equipment operation efficiency, ensure online product quality, promote energy saving and reduce consumption, this paper proposes standardization of life cycle management information system for cigarette equipment based on TnPM (total normalized productive maintenance) management concept, equipment performance evaluation and health management idea.


Today's marketing is highly sought after by products that are marketed through social media or through print media. One of the social media that is not less attractive to many people is YouTube. Through YouTube media consumers are interested in the products offered. The marketing strategy through YouTube attracts consumers because most people tend to spend more time accessing YouTube. This research uses quantitative methods by collecting data through distributing questionnaires to consumers who shop through YouTube. After conducting the research, the results of the study showed that there was a significant and positive influence between the Marketing Strategy variables on the Purchase Decision, while the Persuader Perspective variable also significantly and positively affected the Purchasing Decision. After that, together between the Marketing Strategy variables and Persuader's Perspective also influence the Purchasing Decision. Keywords  Subscriber, YouTube, Marketing Strategy.


Abstract. Nitrogen dioxide (NO2) column density measurements from satellites have been widely used in constraining emissions of nitrogen oxides (NOx = NO + NO2). However, the utility of these measurements is impacted by reduced observational coverage due to cloud cover and their reduced sensitivity toward the surface. Combining the information from satellites with surface observations of NO2 will provide greater constraints on emission estimates of NOx. We have developed a deep-learning (DL) model to integrate satellite data and in situ observations of surface NO2 to estimate NOx emissions in China. A priori information for the DL model was obtained from satellite-derived emissions from the Tropospheric Chemistry Reanalysis (TCR-2). A two-stage training strategy was used to integrate in situ measurements from the China Ministry of Ecology and Environment (MEE) observation network with the TCR-2 data. The DL model is trained from 2005 to 2018 and evaluated for 2019 and 2020. The DL model estimated a source of 19.4 Tg NO for total Chinese NOx emissions in 2019, which is consistent with the TCR-2 estimate of 18.5 ± 3.9 Tg NO and the 20.9 Tg NO suggested by the Multi-resolution Emission Inventory for China (MEIC). Combining the MEE data with TCR-2, the DL model suggested higher NOx emissions in some of the less-densely populated provinces, such as Shaanxi and Sichuan, where the MEE data indicated higher surface NO2 concentrations than TCR-2. The DL model also suggested a faster recovery of NOx emissions than TCR-2 after the Chinese New Year (CNY) holiday in 2019, with a recovery time scale that is consistent with Baidu "Qianxi" mobility data. In 2020, the DL-based analysis estimated about a 30 % reduction in NOx emissions in eastern China during the COVID-19 lockdown period, relative to pre-lockdown levels. In particular, the maximum emission reductions were 42 % and 30 % for the Jing-Jin-Ji (JJJ) and the Yangtze River Delta (YRD) mega-regions, respectively. Our results illustrate the potential utility of the DL model as a complementary tool for conventional data-assimilation approaches for air quality applications.


Sef(similar expression to fgf genes) was identified as a feedback antagonist of FGF signaling in zerbrafish,mouse and human.Sef has been reported to function in different ways,however the regulation of Sef stability remains unknown.The possible role of c-Cbl in the regulation of Sef protein degradation was investigated.Results from coimmunoprecipitation and immunostaining assays reveal that hSef colocalizes and interacts with c-Cbl.Data suggest that the interaction between hSef and c-Cbl results in the ubiquitination and subsequent degradation of the hSef protein.It was proposed that c-Cbl may serve as a modulator to regulate Sef protein stability during FGF signal transduction.


The present invention relates to a method for casting an acryl film, the method comprising the steps of: an acrylic resin film material is injected into the space formed by a pair of substrates and a gasket positioned between the pair of substrates; and curing the acrylic resin membrane material. Shrinkage ratio of the gasket after the acryl film is subjected to the curing step is not less than 10%, after the gasket or acrylic resin film shrinkage of the curing step is greater than or equal to the shrinkage of the acrylic resin film material.


The following article touches upon the problems of researching the prepositions with the meaning of temporality in the comparative aspect based on the material of modern Russian and French languages.


In analyzing the foundation that huainan and huaibei coal mines finish construction the inquisition characteristics of the acceptance environment influence,to inquisition of procedure and contents,investigate method,evaluation analysis means' etc.make a first step study.


The present invention relates to a light emitting display and a luminance control method for controlling the brightness of pixels in the measurement of the current flowing to the light emitting element. A light emitting display device according to the invention a plurality of pixels having a pixel circuit coupled to the first electrode of the data line, the light emitting element and the light passing the scanning line, a data signal for transmitting a scanning signal, respectively, the second light emitting element a controller for controlling the luminance of the plurality of pixels based on the current measured at a plurality of power supply lines are respectively connected to the electrode, the current measuring unit for measuring a current flowing through the plurality of power lines, and the current measuring unit. Light emitting diode display, the current measurement, the brightness correction, a gamma correction


The city, the urban space is in the process of continuous urban change, a process that is encouraged by complex structures and systems, a process that also needs to be addressed, discussed to be addressed and redirected. The topic of my study is the city center as a central and representative area of each city with, the application of spatial syntax analysis in urban research and planning. Sustainable development of a solution that can be characterized by a process in which the quality of life is developed in such a way that social and economic life is not a threat to the survival of environmental elements and ensure the improvement of their continuity. An appropriate downtown infrastructure solution that would provide a resilient center that is able to change. It is an attempt to multidisciplinary thinking as an urban phenomenon in all dimensions at once: social, ecological, economic and cultural. The process, which will be a continuation, which defines a number of steps in transforming the city for the coming decades.


Previous studies have shown that fastigial nucleus stimulation (FNS) reduces tissue damage resulting from focal cerebral ischemia. Although the mechanisms of neuroprotection induced by FNS are not entirely understood, important data have been presented in the past two decades. MicroRNAs (miRNAs) are a newly discovered group of non‐coding small RNA molecules that negatively regulate target gene expression and are involved in the regulation of cell proliferation and cell apoptosis. To date, no studies have demonstrated whether miRNAs can serve as mediators of the brain's response to FNS, which leads to endogenous neuroprotection. Therefore, this study investigated the profiles of FNS‐mediated miRNAs. Using a combination of deep sequencing and microarray with computational analysis, we identified a novel miRNA in the rat ischemic cortex after 1 h of FNS. This novel miRNA (PC‐3p‐3469_406), herein referred to as rno‐miR‐676‐1, was upregulated in rats with cerebral ischemia after FNS. In vivo observations indicate that this novel miRNA may have antiapoptotic effects and contribute to neuroprotection induced by FNS. Our study provides a better understanding of neuroprotection induced by FNS. MicroRNA (miRNA) is defined as a small non‐coding RNA that fulfills both the expression and biogenesis criteria. Here, we describe a novel miRNA in the rat ischemic cortex expressed after 1 h of fastigial nucleus stimulation (FNS). The miRNA was functionally characterized by secondary structure, quantitative expression, the conservation analysis, target gene analysis, and biological functions. We consider rno‐miR‐676‐1 to be a true microRNA and present evidence for its neuroprotective effects exerted after induction by FNS.


Following comprehensive,leading,feasible and scientific principles,this paper constructs the evaluation index system of regional urbanization development level.Based on this,the author measures urbanization comprehensive development level using Mean-Squared Deviation Weight Method,and emphatically discusses the spatial variation features of urbanization development level based on 17 cities.The results indicate that the environment of human settlements index displays the east superior obviously than the west;the infrastructure index shows a typical "two high two low" pattern,apex-paddy interlacedly from east to west;while the economic development index,the social development index,the life style index have the same spatial distribution pattern,and the pattern has evident correlations with the urbanization development index basically,displays "┣" mode roughly.


The downwind propagating sound field from a monopole source is solved by applying a Hankel transform in a stratified medium, according to the method by Rasmussen. The influence of the noise barrier is calculated using the equivalent source method with ring sources of zero order placed inside the fictious surface of the barrier. At the surface the boundary condition is fulfilled by choosing the correct amplitudes of the equivalent sources. The total field is then calculated as the sum of contributions propagated downwind from both the original source and the equivalent sources.


Non‐invasive laser diagnostics are capable of measuring p absolutely and δp/p of high‐energy H− ion beams. A Q‐switched Nd:YAG laser, operating at 0.266 μm, can excite narrow auto‐ionizing resonances in the H− ion. The measured width of the resonances is sensitive to δp/p of the ion beam. Doppler tuning of the laser photon energy, by angle tuning, allows the absolute beam energy to be measured. The principle of these diagnostics was tested at LAMPF during a series of atomic physics experiments. It was found that the absolute energy of the H− beam could be measured to an accuracy of 10−4 and the momentum spread to an accuracy of 10−5. The diagnostic was sensitive to dephasing of a single rf module on the LAMPF linac. The applicability of this type of diagnostic for H− beams of different phase space and energy than LAMPF will be presented.


Background: Aim of our study was to analyze if we can acuratly predict uneventful post operative course pre operatively in gastrointestinal and HPB surgery patients so that we can better explain risk benefit ratio to the patients and prognostify the results. Material and Methods: We retrospectively evaluated patients who have undergone gastrointestinal and hepatobiliary surgery at our institute in last 3 years and analyzed 90 days mortality and morbidity rates among these patients. We described any 90 day morbidity and mortality as an event. We performed univariate and multivariate analyses for factors predicting an event. Then based on pre operative factors that predicted an event we formulated a score and then evaluated sensitivity, specificity, positive predictive and negative predictive value of that score and also evaluated ROC curve. We also performed kaplan-meier analysis for 90 days event free survival. Statistical analysis was done using SPSS version 23. Results: Total 264 patient operated for gastrointestinal and HPB surgeries between april 2016 to may 2019 were evaluated .Total 45 (17%) events occurred. On univariate analysis CDC grade, ASA score,Operative time,Blood products used, emmergency surgeries and open surgeries predicted an event.We developed score based on pre operative factors like ASA score, CDC grade of surgery,open surgery and emmergency surgeries included in the score. Each variable was given 1 point.We proposed score grater than 2 was associated with 90 day event. This score had sensitivity of 77.78%, specificity of 81.65%. low positive predictive value of 46.67% but very high negative predictive value of 94.68%. AUROC showed AUROC of 0.797 (p < 0.0001, 95 % confidence interval 0.721-0.874). Pre operative fitness score, Open Surgery and operative time independently predicted an event on multivarious analysis. (p =0.003 and 0.026 respectively.) Conclusions: Pre operative fitness score accurately predicts uneventful post operative course in gastrointestinal and hepatobiliary surgery.


Physiology has been a foundational course in medical curriculums for several decades. Traditionally, medical physiology relies on biophysical principles and equations; and medical students are expected to use them to solve mathematical problems on USMLE Step 1 exams. As the number of osteopathic schools is increasing, and the two postgraduate medical education systems, AOGME and ACGME, are merging to a single accreditation system, there is a growing interest in student performance on the osteopathic board exam (COMLEX‐USA Level 1). We know the two board exams are written by different groups. However, it remains unknown how well traditional (allopathic) physiology courses prepare students for COMLEX‐USA Level 1 examinations. We at WCUCOM want to give our students every opportunity to succeed. Our overall goal is to map our Medical Physiology I and II courses to available USMLE and COMLEX‐USA review books. We started with mapping the Cardiovascular and Respiratory physiology blocks, because these areas were challenging for our students in the past. We used First Aid for the Basic Sciences: Organ systems (3rd edition) as our USMLE Step 1 resource, and Kaplan COMLEX Level 1 Physiology lecture notes 2018 as our COMLEX resource. The OMS‐1 Medical Physiology I course has 72 lectures. Cardiovascular and respiratory physiology are taught in 23 and 10 physiology, and 10 and 5 pathophysiology lectures, respectively. We mapped the lecture objectives and content of these 48 lectures to both review textbooks. Some of our major observations included: The USMLE book was more focused on equations, while the COMLEX book focused primarily on applications. The COMLEX book, but not the USMLE book, discussed cardiac inward rectifier K+ and T‐type Ca2+ currents in pacemaker cells. The USMLE book only mentioned jugular venous pressure (JVP) waves in the text, while the COMLEX book detailed figures of JVP waves under normal and pathological conditions. In the COMLEX book capillary fluid exchange (Starling forces), as well as systemic and pulmonary edema formation was discussed in the fluid compartments section at the beginning, while it was in the cardiovascular and respiratory sections in the USMLE book. While both books discussed lung mechanics, volumes, and pulmonary function tests, the COMLEX book explained differences between restrictive and obstructive diseases in more detail. The COMLEX book had an entire section on determinants of alveolar gas content including the effects of metabolism, which was not detailed in the USMLE book. We have already made lecture content revisions based on the material covered in the COMLEX review book and will continue to do so with further mapping of other organ systems. We found that although the material is very similar, COMLEX requires a more in‐depth knowledge of certain areas, and focuses especially on clinical application of physiology and pathophysiology. We conclude that it is important to incorporate the material from both USMLE and COMLEX sources to best equip our students for their board examinations.


The direct least mean p-norm (DLMP) algorithm is a robust algorithm for estimating latency changes of evoked potential (EP) signals under both Guassian and the fractional lower orderα-stable noise conditions.Based on the fractional lower order statistics theory,the deterministic averaging method and two lemmas introduced and proved,this paper gives an analysis of the convergence property of the DLMP algorithm theoretically.The results of the analysis indicate that,if the EP latency change is an integer multiple of the sampling interval,the DLMP algorithm gives an unbiased estimate of the latency change;otherwise,the algorithm yields an estimate which differs from the true latency change by at most half of a sampling interval.


ABSTRACT The activity of self-translation may be seen as a mise-en-scène of the hybrid auctorial self, as well as an ideal stage for a reconstruction of meanings, through a second original. As a (re)creative paradigm, self-translation echoes the concept of poiesis as a 'bringing into appearance', according to Heidegger's interpretation, namely as a crystallisation of the refracted facets of language and self. In this connection, the genetic approach may represent a tool to access the aesthetic world of the writer (the poietes) and to explore his (re)creative process. This paper discusses the case-study of the distinguished Taiwanese poet Yu Guangzhong (1928–2017), and his self-translated poetry collected in Shouye ren 守夜人/The Night Watchman. Through a comparative reading of three selected bilingual poems with their manuscript versions, this paper aims to investigate Yu's poetics of self-translation, while observing through the multi-layered spectrum of a linguistic and cultural rendering.


Besides the human and veterinary medicine, the antimicrobials have usage in various areas as aquaculture, food technology, agriculture and animal husbandry [1]. The total amount of antimicrobials used worldwide is estimated in 100,000-200,000 tonnes/year [2-4]. Since 1950s, tetracycline (TC) antibiotics which rank second both in the production and usage of antibiotics worldwide have been widely used in human and veterinary medicine to treat bacterial infections and promote animal growth [5-9]. The global sales of TCs were 1.6 billion dollars in 2009 [6-10]. These properties support their usage especially in developing nations [11-13].


We use mathematical induction method to prove the Poincare Formula. To demonstrate the usefulness of this formula, we provide five examples. This formula is related to a broad class of counting problems in which several interacting properties either all must hold, or none must hold. When there are only two or three events that need to be counted, we usually use a Venn diagram. In section 4, we present a general mathematical formula to count any finite number of inclusion and exclusion events. This leads to an easy way to apply the Poincare Formula to define the probability.


Herein, we report zinc oxide (ZnO) nanoparticles (NPs) synthesized by a
simple precipitation method using zinc acetate dihydrate (Zn(CH3CO2)2. 2H2O) and sodium hydroxide
(NaOH) precursors in aqueous media.

Synthesized material was annealed at different temperatures to check phase formation
and its purity.

At room temperature, the sample shows the formation of zinc hydroxide and at high temperature
(100, 200, and 300°C) shows the formation of ZnO. Synthesized materials were analyzed
by different techniques. X-ray diffraction analysis shows the formation of a hexagonal crystal
structure. Morphological features were analyzed by the SEM technique which shows agglomerated
nanoparticles.

The optical properties of ZnO were studied by using UV analysis and showed intrinsic
excitonic transition property of the ZnO semiconductor. Further, with an increase in annealing
temperature crystalline size, agglomeration of nanoparticles found to be increased whereas the
bandgap decreased.


Elevated levels of reactive oxygen species at sites of chronic inflammation cause oxidative DNA damage in epithelial cells, contributing to carcinogenesis. Aberrant silencing of key genes by promoter CpG island DNA hypermethylation occurs in many cancers that form at sites of chronic inflammation. Yet, it is not completely understood how these aberrant DNA methylation alterations are initiated. We hypothesize that the recruitment of epigenetic silencing proteins to sites of oxidative DNA damage is important for initiating DNA methylation. Here we demonstrate that after hydrogen peroxide (H2O2) treatment, mismatch repair proteins MSH2 and MSH6 become localized to sites of oxidative DNA damage, resulting in the recruitment of DNA methyltransferase 1 (DNMT1) and Polycomb repressive complex 2 (PRC2) members to chromatin. This recruitment results in the formation of repressive chromatin in the promoters of tumor-suppressor genes and the concomitant transient reduction in their expression. We sought to further understand the mechanism that drives H2O2-induced MSH2 and MSH6 chromatin binding. Janus kinase 2 (JAK2) is a kinase that is canonically known to be activated by cytokines and growth hormones and phosphorylate the transcription factor signal transducer and activator of transcription (STATs). Here, we demonstrate that in response to treatment with H2O2, but not interleukin 6 (IL-6), JAK2 translocates to the nucleus and interacts with MSH2 and MSH6. Nuclear JAK2 is important for H2O2-induced chromatin interaction of MSH2, MSH6, DNMT1 and PRC2 members. Interestingly, H2O2-induces a global and site-specific increase in trimethylation of histone H3 at lysine 27 (H3K27me3) that is also dependent on JAK2. Furthermore, by analyzing TCGA datasets, we demonstrate high JAK2 mRNA expression correlates with CpG island methylator phenotype (CIMP) status in gastric and colorectal cancer. All together, these findings suggest JAK2 plays a key role in initiating oxidative damage-induced epigenetic alterations during inflammation-driven tumorigenesis. Ultimately, understanding the mechanism of initiation of cancer-specific promoter DNA hypermethylation may lead to treatment strategies to reduce aberrant epigenetic changes induced by chronic inflammation and therefore reduce tumorigenesis. Citation Format: Ning Ding, Sam Miller, Heather O9Hagan. JAK2 regulates oxidative damage-induced epigenetic alterations [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 5317.


Properties of the Roper resonance, the first scalar excitation of the nucleon, are determined. Pole positions and residues of the P11 partial wave are studied in a combined analysis of pionand photo-induced reactions. We find the Roper pole at {(1371 ± 7) − i(92 ± 10)} MeV and an elasticity of 0.61 ± 0.03. The largest decay coupling is found for the Nσ (σ = (ππ)-S-wave). The analysis is based on new data on γp → pπ0π0 for photons in the energy range from the two-pion threshold to 820 MeV from TAPS at Mainz and from 0.4 to 1.3 GeV from Crystal Barrel at Bonn and includes further data from other experiments. The partial wave analysis excludes the possibility that the Roper resonance is split into two states with different partial decay widths. © 2007 Elsevier B.V. All rights reserved. PACS: 11.80.Et; 13.30.-a; 13.40.-f; 13.60.Le DOI of companion paper: 10.1016/j.physletb.2007.11.054. * Corresponding author. E-mail address: email@example.com (E. Klempt). 0370-2693/$ – see front matter © 2007 Elsevier B.V. All rights reserved. doi:10.1016/j.physletb.2007.11.055 CB-ELSA and A2-TAPS Collaborations / Physics Letters B 659 (2008) 94–100 95 The lowest-mass excitation of the nucleon, the Roper N(1440)P11 resonance with spin and parity J = 1/2+, and the second scalar nucleon excitation N(1710)P11 [1], remain to be the most enigmatic states in baryon spectroscopy. In the bag model [2] and in the Skyrme model [3], the Roper resonance was interpreted as surface oscillation, also called breathing mode. In quark models, two low-mass scalar excitations of the nucleon are predicted. Using a linear confining potential and one-gluon-exchange [4] or instanton-induced interactions [5], a level ordering is calculated in which the mass of the N(1440)P11 exceeds the mass of the negative-parity state N(1535)S11 by 80 MeV; experiments find it ∼ 100 MeV below. The spacing between the two scalar excitations is predicted to be ∼ 220 MeV [4–6] while experiments find 270 MeV [1]. When one-gluon exchange interactions are replaced by exchanges of Goldstone bosons, the N(1440)P11 mass can well be reproduced [7], the N(1710)P11 mass was not calculated. Lattice gauge calculations indicate that the first scalar excitation of the nucleon should be expected above N(1535)S11 [8]. Compared to model and lattice predictions, the mass of the Roper resonance is too small; compared to other low-mass resonances, its width too large. These problems would not occur if N(1710)P11 were the first radial scalar excitation of the proton. The Roper resonance can then be interpreted within a coupled-channel meson exchange model based on an effective chiral-symmetric Lagrangian [9]; no genuine N(1440) (3 quark) resonance was needed to fit πN phase shifts and inelasticities, in agreement with [10]. Motivated by the Q2 dependence of the Roper helicity amplitude which would seem to suggest a hybrid nature [11], Capstick and Page [12] calculated masses of baryonic hybrids. Their masses were, however, too large to interpret the Roper resonance as a hybrid. The Θ+(1530), a baryon with positive strangeness, which may have been observed in low-statistics photo-production experiments [13–16], made the Roper resonance [17] and/or the N(1710)P11 [18] to viable pentaquark candidates. The existence of a very narrow P11 state in the mass region 1650–1750 MeV was investigated in [19]. The fading evidence for Θ+(1530) [20,21] makes this interpretation less attractive. Morsch and Zupranski [22] suggested the Roper mass region might house two resonances, one at 1390 MeV with a small elastic width and large coupling to Nππ , and a second one at higher mass—around 1460 MeV—with a large elastic width and small Nππ coupling. The former resonance was found to be produced in πN scattering, and in α-proton scattering using an α beam of Eα = 4.2 GeV kinetic energy; the latter resonance was suggested to be excited by γN . The two resonances may have rather different wave functions [23]. Studies of the reaction pp → ppπ+π− suggested that the lowenergy tail of the Roper resonance might decay to both Nσ and π [24]. Obviously, the P11 partial wave is not sufficiently constrained by precision data and supports very different interpretations. In this Letter, we present data on γp → pπ0π0 of the A2TAPS Collaboration at the Mainz Microtron (MAMI) electron accelerator [25] and of the CB-ELSA Collaboration at the Bonn ELectron Stretcher Accelerator (ELSA) [26]. The Bonn setup and the analysis method was described briefly in the preceding paper [27]. Here we give only a short summary of the TAPS setup, for more details see [28]. Earlier data taken at MAMI [29,30] have smaller statistics and are not discussed here. The photon energy at MAMI covered the range 285– 820 MeV. The photon energies were measured in the Glasgow tagged photon facility [31] with an average energy resolution of 2 MeV. The TAPS detector [32,33] consisted of six blocks each with 62 hexagonally shaped BaF2 crystals arranged in an 8 × 8 matrix and a forward wall with 138 BaF2 crystals arranged in a 11 × 14 rectangle. This setup covered ≈ 40% of 4π . The γp → π0π0p reaction channel was identified by constructing the 4-momenta of the two neutral pions from their γ γ decays; proton detection was not required in the analysis. The π0 mesons were detected via their 2γ decay and identified by their invariant mass. The mass of the missing particle was calculated from the four-momenta of the pions, and the beam energy Eγ using the mass of the target proton. The resulting distribution is shown in Fig. 1(a) and demonstrates the unambiguous identification of the reaction γp → π0π0p. At incident beam energies above the η production threshold of Eγ = 707 MeV, a possible background from the η → 3π0 decay with one undetected π0 can be cleanly separated from the reaction of interest (see Fig. 1(a)). Further details are given in [34]. In Fig. 1(b) the total cross section is displayed. Two peaks due to the second and third resonance region are observed, with peaks at ∼ 1500 and ∼ 1700 MeV. There is good general agreement between the three data sets. The GRAAL data [35] fall off at high masses more rapidly than the CB-ELSA data. At low energies, the TAPS data fall below the CB-ELSA data while the peak cross sections of all 3 experiments agree reasonably well. The discrepancies show the difficulties of extracting total cross sections when the full phase space is not covered by the detector. Note that the extrapolation was done differently: the CB-ELSA and the A2-TAPS Collaborations used the result of this partial wave analysis; the GRAAL Collaboration used a simulation based on γp → +π0 and γp → pπ0π0 phase space. The inclusion of both, CB-ELSA and TAPS data, provides an additional tool to estimate the systematic error of the experimental data. The fit curves in Fig. 1(b) are discussed below. The total cross section gives only a very superficial view of the reaction. Fig. 2(a) shows the experimental pπ0π0 Dalitz plots, Fig. 2(b), (c) the pπ0 and π0π0 mass distributions. The solid line represents the result of a fit, the dashed line represents the distribution of reconstructed phase space events. The projections are not corrected for detection efficiency to allow the reader to compare data and fit directly. From the π0p mass distributions we conclude that the isobar plays an important role in the two-pion photoproduction dynamics. The π0π0 mass distributions are featureless but show strong deviations from phase space. Even the Dalitz plot and the projections do not carry the full information on the reaction dynamics. The full sensitivity of the data can only be exploited using an event-based likelihood fit. The data presented here were subjected to a partial wave analysis based on the Bonn–Gatchina approach [36,37]. Com96 CB-ELSA and A2-TAPS Collaborations / Physics Letters B 659 (2008) 94–100 Fig. 1. (a) TAPS: Missing mass MX − mp calculated from two detected π0 mesons for incident beam energies Eγ 820 MeV (data: symbols with errors, π0π0 simulation dotted line, η simulation dashed line). The cut to eliminate η background is indicated. (b) Total cross sections for γp → pπ0π0. The shaded area below the zero line represents the systematic error of the CB-ELSA data, the solid line a PWA fit. There are two PWA solutions, marked 1 and 2, giving a similar likelihood (see text). The D33 partial wave (dotted line) gives the strongest contribution to the second resonance region, followed by D13 (dashed–dotted line) and P11 (dashed line). The D13–D33 interference generates the dip between the second and third resonance region. Fig. 2. Dalitz plots (a) and pπ0 (b) and π0π0 (c) mass distributions for TAPS (upper row) and for CB-ELSA (lower row) data for γp → pπ0π0. The CB-ELSA data shown here are restricted to M 1.55 GeV. In (b), (c), data are represented by crosses, the fit as histogram. The dashed lines represent the phase space contributions within the acceptance. The distributions are not corrected for acceptance which are different for the two experiments, leading to different distributions. pared to a previous analysis [38,39], several new data sets are included in this analysis. A list of additional data and a description of the partial wave analysis method can be found in [40]. In the case of two-particle final states (including γp → ΛK+ and γp → ΣK), angular distributions are fitted; three-body final states like Nπ0π0 and pπ0η [41] undergo an event-based likelihood fit. The reactions most relevant for the present analysis are collected in Table 1. The πN elastic scattering [46] amplitude provides a strong constraint for Nπ partial decay widths of resTable 1 The reactions most important for the study of properties of the Roper resonance 1 γp → pπ0π0 Figs. 1, 2 This work 2 γp → pπ0 Figs. 3–5 [42–45] 3 πN → Nπ Fig. 6 [46] 4 π−p → nπ0π0 Fig. 7 [47] onances in this partial wave. The inclusion of data on γp → pπ0 [42–45] and on π−p → nπ0π0 [47] over-constrai


Nano-copper powder is prepared by liquid phase reduction method in ethylene glycol solvent system. Nano-copper paste is prepared by mixing with organic carriers and subjected to pressureless sintering. The influence of different reducing agent systems on the particle size and morphology of nano-copper powder are studied. The sintering properties of the copper paste are tested by TEM, XRD and SEM. The results indicate that the synthesized product of using ethylene glycol as the reaction solvent and reducing agent is pure copper power and particle size from 100 nm to 200 nm at 160°C; The nano-copper paste can achieve metallurgical bonding at 300°C and the density of the sintered layer gradually increases with the sintering time prolonged, the porosity is gradually reduced, and the sintering of the nano-copper powder for 30 minutes is basically stable.


PurposeFrom the signaling theory perspective, the current study explores various drivers of brand transparency and its effect on users' interactions with food delivery apps.Design/methodology/approachFirst, a set of precursors of brand transparency of food delivery apps from focus group discussions was identified. Next, an integrated model tests the impact of brand transparency, perceived risk and brand trust on users' ordering frequency. Data collected from 522 users were analyzed using the partial least squares structural equation modeling method.FindingsThe outcomes showed the effectiveness of brand communications as the strongest indicator of brand transparency. Moreover, brand transparency favorably influences users' brand trust and ordering intention and negatively influences perceived risk. Hygiene rating attenuates the adverse effects of perceived risk.Originality/valueThe current study is a pioneering attempt that offers ways for online food delivery providers to build brand transparency, lessen users' risk perceptions and foster greater use of apps in the post-pandemic scenario.


Alzheimer's disease (AD) is a progressive and irreversible neurodegenerative disorder leading to dementia in the elderly inhabitants. Increasing evidence advises that oxidative stress that is normally associated with aging is an obvious and early feature of AD and plays a role in its pathogenesis. The present study was designed to evaluate the possible neuroprotective activity of Ginkgo biloba (Gb) and / or Peganum harmala (Ph) extract against AD in a rat model. AD was induced by chronic administration intraperitoneal injection of scopolamine (0.7 mg kg -1 , i.p.) to rats for a period of 7 days. The Gb (120 mg/kg b.wt.) and Ph (187.5 mg/kg b.wt.) were administrated to AD rat group orally daily for a period of 30 days. The results revealed that the levels of thiobarbituric acid reactive substances and Xanthine oxidase were significantly increased, even though the activities of superoxide dismutase and catalase, as well as the reduced glutathione, were significantly decreased in the brain homogenate of Alzheimer group. Additionally, brain acetylcholinesterase as well as alkaline phosphatase, acid phosphatase, alanine aminotransferase, aspartate aminotransferase and lactate dehydrogenase activities were significantly increased. On the other hand, the administration of Gb, Ph and coadministration of those test herbs acquired potential therapeutic effects on improving the neurodegenerative disorder in rats through suppressing lipid peroxidation, augmenting endogenous antioxidant enzymes, and reducing acetylcholinesterase activity in the brain. It might be concluded that a mixture extract, by its antioxidant constituents, could modulate scopolamine-induced oxidative stress and enzyme activities in the brain. INTRODUCTION: Alzheimer's disease is a pathological brain disease and the most frequent cause of dementia 1, 2 . Patients with AD suffer a gradual deterioration of memory and other cognitive functions, which eventually causes a complete incapacity and fatal within 3 to 9 years


The article aims to shed light on some recent empirical neuroscience and psychology researches, which target music perception and cognition. The explosive growth of data collected and the measurement preciseness should correlate with the clarity of conclusions made on their basis. However, for the skilled music practitioners, such correlation is not obvious. The author propose a definition of the term musician, based on the concept of musical cognitive status. The purpose is to provide the adequate support and refinement of the experiment design procedures for the cross-disciplinary researches, dealing with selection of music stimuli material, conceptual theoretical foundations, and cultural-dependent cognitive backgrounds of the participants. The author considers that music cognition of performers is framed by the specific music idea, represented in the acoustically certain sound image, transformed to the appropriate gesture. This clear image is generated successfully when the performer has a clear artistic idea of musical sense and content. The specific types of perception determine the content-consuming habits. The degree of perceptual accessibility of sounding musical phenomena is also determined by the peculiarities of both musical and linguistic perception matrix, rooted in culture. In order to avoid the waste of research resources, author considers several investigation paths, coming from the methodology of philosophic anthropology, focused on the cultural and language-dependent dimension of music discourse.


Two arylbutadiene dimers of the 3-aryl-4-styrylcyclohexene series together with a novel C6-C4 monomer (2-(3,4-dimethoxystyryl)ethanol) have been isolated from Zingiber cassumunar. Due to their co-occurrence and the chemical similarity of one portion of the molecules, a possible biosynthetic relationship between the cyclohexene dimers and the phenylnaphthaquinones of Z. cassumunar, based on Diels-Alder reactions, is suggested.


The unemployed are a heterogeneous group comprising the able and disabled, young and old, men and women, black and white, unskilled and highly skilled. It includes those who have only recently lost their jobs and those who have been out of work for many years, those who have lost their jobs for the first time and those who have a history of losing their jobs. It also includes young people who have never been employed since leaving full‐time education. These are just a few of the many dimensions along which this heterogeneity can be described. Activities which may help some segments of the unemployed population may be irrelevant to others. This article cannot hope to present an exhaustive treatment of all the possible ways forward. Given this caveat, however, a broad‐brush attempt will be made to examine some of the ways in which the unemployed can be helped, to identify the contribution the personnel manager can make to helping the unemployed, and to comment on the assumptions that underpin the various ap...


This article - based on approaches in research on social and political networks and the concept of sociabilite - examines the activities of the former Russian Cadets in politics and social life in the emigration after the dissolving of their classical party structures in mai 1921. The appearance of leading personalities of former Cadets within social, political and cultural public life of the exile community is for this purpose illustrated and analized. The main source for this research were two chronicles about Russian emigration in Germany and in France. The great number of different connections and activities of the former Cadets presented in this article, shows their important positioning within the exile community, for example in the big Russian newspapers in exile or in central emigrant organisations, as well as their secondary activities, for example their contributions to small cultural or literal circles or their participation in social events. This article argues that the potential of the former Cadets to exert influence on political and social life of the exile community was determined by their diverse central and secondary positions and connections.


In this era where advances in information technology is applied in every field, we are required to follow the progress of these technologies by implementing software so that we can work effectively and efficiently in achieving its objectives. Including one in the field of religious education. Along with the times today many people who have not memorized muskim about prayer. Given a collection of data management or processing of prayer-prayer is good, then the information sought will be more accessible so can shorten the time it is used. The presence of science and technology information that exist today are the main factors providing service that is fast, accurate, organized and reliable in the aspects of life, among which is the educational institution, in order to develop and improve the quality of education. In a computer-assisted learning, the public face and interact directly with the computer. This final project aims to create a pembelajaranyang system can be accessed anywhere and anytime. It provides a database of information systems and facilities to learn about prayer-prayer. The program was created using Visual Basic 6.0 software and Photoscape. Universitas Sumatera Utara DAFTAR ISI Halaman Persetujuan ii Pernyataan iii Penghargaan iv Abstrak vi Abstract vii Daftar Isiv iii Daftar Tabel xi Daftar Gambar xii BAB 1 PENDAHULUAN 1 1.1 Latar Belakang 1 1.2 Rumusan Masalah 3 1.3 Batasan Masalah 3 1.4 Tujuan Penelitian 4 1.5 Manfaat Penelitian 4 1.6 Metode Penelitian 4 1.7 Sistematika Penulisan 5 BAB 2 LANDASAN TEORI 7 2.1 Pengertian Perancangan 7 2.2 Pengertian Pembelajaran 7 2.3 Pengertian Do'a 9 2.3.1 Prinsip-prinsip berdoa 9 2.3.2 Hal-hal yang perlu dijauhi dalam berdoa 11 2.3.3 Fungsi doa 12 2.3.4 Adab berdoa 13 2.3.5 Tata cara berdoa 15 2.4 Aspek Dasar Komputerisasi 15 2.5 Pengertian Data, Database, dan Database Management System (DBMS) 17 2.5.1 Data 17 2.5.2 Database 18 2.5.3 Database Management system (DBMS) 19 2.5.4 Tujuan Pengolahan Data 20 2.6 Pengenalan Visual Basic 6.0 20 2.7 Sejarah Visual Basic 6.0 21 2.8 Keunggulan Visual Basic 6.0 25 2.9 Tampilan Visual Basic 6.0 25 2.9.1 Tampilkan Visual Basic 26 2.9.2 Tampilan Utama (Desain) 26 2.10 Photoscape 32 2.11 Data Flow Diagram 33 2.12 Flowchart 34 2.12.1 Simbol-simbol pada flowchart 34 Universitas Sumatera Utara BAB 3 PERANCANGAN SISTEM 37 3.1 Perencanaan Sistem 37 3.2 Perancangan Sistem 37 3.3 Perancangan Database 44 3.4 Flowchart Program 47 BAB 4 IMPLEMENTASI 50 4.1 Pengertian Implementasi 50 4.2 Tujuan Implementasi Sistem 51 4.3 Tampilan Program Aplikasi Doa Sehari-hari untuk Umum Berbasis Visual Basic 6.0 51 4.3.1 Tampilan awal aplikasi 52 4.3.2 Tampilan menu utama aplikasi 52 4.3.3 Tampilan menu konsep dalam berdo'a 53 4.3.4 Tampilan menu do'a shalat 54 4.3.5 Tampilan menu do'a sehari-hari 56 4.3.6 Tampilan menu al-ma'tsurat 56 BAB 5 PENUTUP 58 5.1 Kesimpulan 58 5.2 Saran 58 Daftar Pustaka Lampiran : Listing Program Kartu Bimbingan Tugas Akhir Mahasiswa Surat Keterangan Universitas Sumatera Utara


Engineering companies within the High Value Low Volume (HVLV) industry are facing ever-increasing challenges due to the shift towards Product Service Systems (PSSs), and the inclusion of Corporate Social Responsibilities (CSRs) and environmental legislation into their business strategy. Addressing these challenges requires a fundamental understanding of data and information across the entire Product Lifecycle and there is a concern as to whether the current systems for capturing and managing data and information across the product lifecycle can provide the learning and knowledge necessary. To begin to understand this concern, the paper explores the current state-of-the- art research in applying Knowledge Discovery and discusses their capabilities and limitations with respect to the product lifecycle. The paper then looks towards 2020 and considers emerging ICT technologies and their possible implications on PLM.


Articulating the theoretical and methodological approach of the Basket of Territorial Goods and Services (BTGS) with the notion of Novelty Production, this article aims to build an analytical framework focused on innovative situations of the "basket effect". To this end, is based on the understanding of the BTGS approach as the result of continuous and cumulative processes of social construction of novelties. In order to illustrate the applicability of this analytical framework, we borrow aspects highlighted in four empirical studies linked to the configuration of the Cooperativa Mista da Flona do Tapajós (Coomflona), located in western Pará. The conjunction of the two approaches illustrates, in the Amazonian scenario in question, instances of governance initiated by social actors that are capable of articulating differentiated and quality attributes, which further enables the configuration of development projects that deviate from conventional forms. Based on the reflections raised here, it is possible to understand Coomflona as an organizational novelty that interrelates different social players in the constitution of a BTGS, in which products - wooden furniture of different categories, bio-jewelry, vegetal leather crafts, liqueurs and food - and services, especially tourism, are intertwined.


Abstract Novel 1-(1-aryl-4,5dihydro-1H-imidazoline)-3-chlorosulfonylourea derivatives 3a–3f were synthesized in the reaction of 1-aryl-4,5-dihydro-1H-imidazol-2-amines with chlorosulfonyl isocyanate. The second series of compounds 4a–4f was prepared from the respective 1-(1-aryl-4,5-dihydro-1H-imidazoline)-3-chlorsulfonylureas 3a–3f and 1,1′-carbonyldiimidazole (CDI). The selected compounds were tested for their activity against Herpes simplex virus and coxsackievirus B3 (CVB3). It was determined that three derivatives, i.e 3d, 4a and 4d are active against Herpes simplex virus (HSV-1). Compounds 3d and 4c are active against CVB3. Their favorable activity can be primarily attributed to their low lipophilicity values. Moreover, the lack of substituent in the phenyl moiety or 4-methoxy substitution can be considered as the most beneficial for the antiviral activity.


The present study aims to investigate the empowerment of dhuafa (poor people) based on the perspective of Al-Qur'an. According to the standpoint proposed inside the Al-Qur'an, poverty is deemed as a community concern that has to be fixed. Al-Qur'an as Muslims' ways of life can indeed answer all these concerns and problems particularly in liberating and empowering dhuafa. The emergence of dhuafa is inevitably a life reality. Therefore, it is crucial to scrutinize the viewpoint of Al-Qur'an concerning the empowerment of dhuafa. There are several efforts initiated to lessen poverty and empower them based on the Al-Qur'an's perspective specifically the calls for living a life, the calls for giving, the calls for fulfilling alms, the calls for inheritance settlement, the calls for the prohibition of usury, monopoly (ihtikar), and hoarding assets (iktinaz).


The shadow cabinet minister and phone hacking victim wants to see the appointment of internal readers' editors, or ombudsmen, at every newspaper. It is also essential, she writes, for "a clearer exposition of the tensions between the public interest and stories which are of interest to the public."


This study investigates the formulation of surfactant-free Pickering emulsions that release a drug at a specific pH to improve its oral bioavailability. The stabilizing particles composed of magnesium carbonate particles. Pickering oil-in-water emulsions stabilized with magnesium carbonate particles and encapsulating a hydrophobic drug model (ibuprofen) were formulated using a high-energy process with rotor-stator turbo mixer (IKA® T25 digital ultra-Turrax). The experimental approach explored the impact of all formulation parameters, dispersed phase and amount of magnesium carbonate particles on the physicochemical properties of Pickering emulsions. The O/W Pickering emulsion was characterized by a methylene blue test, pH and conductivity measurements, and droplet size determination. In addition, Pickering emulsions stabilized by magnesium carbonate particles have the advantage of being destabilized in acidic medium leading to the release of the active principle via the droplets. The acidic medium release study (pH equal to 1.2) showed ibuprofen release as a function of initial droplet loading and saturation concentration. In the simulated intestinal medium at pH equal to 6.8, we found a better release of ibuprofen from emulsions that already had saturation in an acid medium. Thus, the interest of these Pickering emulsions lies on the fact that their non-toxicity and magnesium carbonate particles allow destabilization of the emulsions and release of the drug. These emulsions not only protect patients from the side effects of acid-based drugs, but also contribute to increase the bioavailability of these acidic drugs.
Keywords: emulsion -Pickering-magnesium carbonate- ibuprofen-oral bioavailability


The estimation for the water vapor included in chemically generated excited oxygen flow and the influence of the water vapor on the excited oxygen species are presented. The concentration of the water vapor in the flow was changed by altering the temperatures of the solution and the cold trap and then, it was estimated by measuring the the pressure change and by measuring the concentration of the excited oxygen molecules. The fraction of O2(1Δ) to the total oxygen did not change with the water vapor pressure, but the concentration of O2(1Σ) changed significantly. Applying the high sensitivity of O2(1Σ) concentration to H2O, the estimation of a small quantity of water vapor concentration was available in the system.


Abstract Socio-economic transformations greatly worsened the state of the Arctic regions for residents, which led to a decrease in the population due to the significant migration outflow. Using the balance of the population movement based on data from Rosstat, we estimated the intensity of migratory movement (relocation to permanent residence) and the natural movement of the population, along with the directions of incoming movement and attrition of the population to the general population dynamics in 1991–2000 in the regions of the Arctic zone of Russia. The analysis showed that the population was characterised by greater mobility compared with the population of the country as a whole. The attrition of the population was greater than the incoming population, and the regions of the Arctic zone of Russia were the donors of the population for the rest of Russia.


There are some valuable metals such as copper,lead and silver in the cyanide leach residue of a gold mine in Henan province.A simple flowsheet by using a mixed collector LD is adopted in this experiment to research comprehensive utilization of the cyanide leach residue containing copper,lead and silver.It can gain a copper concentrate which grade is 21.82% Cu and total recovery is 96.58%.A lead concentrate which grade is 58.20% Pb and total recovery is 74.83% has been obtained.This technology has been popularized and good economic and societal gain has been obtained.


The human body may interact with the structures and these interactions are developed through the application of forces due to movement. A structure may undergo changes in their dynamic behavior when subjected to loads. In this paper, the design of a force platform is presented to measure the Ground Reaction Forces (GRF) and acceleration for human gait analysis. The platform consists of two plates placed side by side in relation to the direction of walking. Each plate has three ring-type load cells instrumented with strain gauges. The platform was validated by calibration and uncertainty evaluation in measured parameters. A finite element model was used to evaluate the dynamic features of the platform. The results were frequencies values very close to those measured in the experimental analysis and confirm its adequacy to the use, because the frequencies were higher than the frequencies involved in the human gait. Using the acceleration and force spectrum of walking vertical of several individuals, a biodynamic model for a walking pedestrian was fitted, to represent the whole effect of individuals walking in structures.


Throughout the late twentieth century, and now into the twenty-first, critics have expressed growing anxiety about die slippery boundaries of the Gothic genre. A prime example of this anxiety rings clear in Maggie Kilgour's conclusion to The Rise ofthe Gothic NoveL Kilgour writes diat she has watched die growth of Gothic criticism with "amazement and sometimes horror as the bulk ofgothic criticism has swelled with increasing rapidity to its present monstrous dimensions."1 This observation seems strange because, in the same chapter, Kilgour argues that the increased legitimacy granted to academic study of the Gothic coincides with an important interrogation of the canon as a site ofpower, and with equally importantwork that links social and political conditions with popular fiction. Kilgour may not be expressing horror at a spate of trivial scholarship but at the simply overwhelming quantity of Godiic criticism. But what does Kilgour find so especially frightening about this growth in Gothic criticism? Is it that the Gothic itself narrativizes anxieties? Perhaps a more likely reason is that the anxieties thematized in die Gothic are so spectral, so indecipherable and sublimely broad. By extension, then, the "problem" of too much Gothic criticism lies in the difficulty of defining—of containing—the genre. Critics of the Godiic have tended to deal with the impossibility ofdefining the composite, varying genre by listing its qualities, then qualifying diese lists and implying that die Gothic is particularly difficult to set within boundaries.