s from the 12th Annual Meeting of ISMPP Analysis of publication timelines following clinical trial completion: Understanding industry trends Amy Monpara, Jessica Hartung, Katherine S. Martinez and Karen Craun MCPHS University, Boston, MA, USA Sanofi Genzyme, Cambridge, MA, USA Objective: Following the completion of clinical trials there is a gap between when evidence is generated and the time it is made publicly available. This analysis was conducted to evaluate manuscript publication timelines following completion of clinical trials in an effort to better understand industry trends. Research design and methods: Clinical trial data from ten top-selling oncology drugs were gathered using ClinicalTrials.gov. Phase 3 interventional studies with completed enrollment and posted results were included–studies for indications unrelated to oncology/hematology were excluded. Corresponding manuscript publication information was gathered–only primary manuscripts linked to the clinical trials were included. Clinical trials and manuscript publication data were recorded and analyzed using descriptive statistics. Results: A total of 105 clinical trials were identified and analyzed. Of these studies, 55 had publications linked to the trial. There was variation in time between primary completion date and manuscript publication date. Three studies had manuscripts published within 6 months of the primary completion date, 4 had manuscripts within 1 year. Fourteen studies had manuscripts published within the second year after primary completion. The largest portion of manuscripts, 24, was published over 2 years after primary completion. A positive trend was observed between study length and time to publication, number of patients and time to publication. Ten studies had a manuscript published prior to the primary completion date listed. Conclusions: The results suggest that clinical trial information is not fully made available to the general healthcare audience in a timely manner. This data warrants further analysis to address variables that are leading to a disparity in timelines, as a means to target and mitigate publication delays. Assessing industry-sponsored medical publications using alternative metrics Catherine Skobe, LaVerne Mooney, Wendy Kopf and Sara Rouhi Pfizer, Inc, New York, NY Adelphi Communications Inc, New York, NY Altmetrics.com, London, UK Objective: The objective was to benchmark the evolution of medical publications metrics from journal citations to social media/digital channels through an evaluation of attention indicators, using the Explorer for Institutions platform from Altmetric.com (AFI). An assessment of industry-sponsored published articles from one company was conducted. Research design and methods: We examined 783 industry–sponsored manuscripts published between Jan 1, 2013 and Dec 31, 2014. DOIs and PMIDs were used to search in AFI. Altmetric.com ranks level of attention by the volume of mentions, rather than the weighted Altmetric score, which is based on an algorithm. Articles that yielded any attention were included in the analysis (n = 413). We assessed the publications to determine the top 10 by level of attention, article type, therapeutic area, and product. Results: Eight of 10 articles with the highest number of mentions were published in the New England Journal of Medicine. The highest level of attention peaked between -1 to 2 months of publication. Of the 6 article types, primary and secondary manuscripts were most prevalent and demonstrated attention levels of 49.5% and 53.5%, respectively, based on a ratio of mentions: number of articles. Similarly, review articles demonstrated a 52.5% level of attention. The products with the highest ratios were product A (50.0%), product B (48.9%), and product C (53.8%). A qualitative assessment of mentions is ongoing. Conclusions: Journals that promote via social media published the most highly mentioned manuscripts. The ratio of mentions to number of articles was approximately 50% by article type or by product. While the number of mentions is of interest, we expect the qualitative evaluation to provide greater insight. Attenuating the role of impact factor by including high-quality publications when reporting publication metrics Miriam Gitler, Julliana Newman, Ian Hollingsworth, Nelson Olivier and Elizabeth Youngdale-Myers MedImmune, Gaithersburg, MD, USA AstraZeneca Ltd, Gaithersburg, MD, USA AstraZeneca Ltd, Innovative Medicines and Early Development, Manchester, UK AstraZeneca Ltd, Innovative Medicines and Early Development, Boston, MA, USA Objective: Impact factor (IF) is determined by dividing ''number of citations generated'' by ''number of citable articles'' published in a journal, the logic being that more important articles are cited more often and the journals with the most important articles have the highest IFs. However, a high IF for a journal does not guarantee that an individual article appearing in that journal is of high impact. As part of our internal publication metrics and reporting, we classified articles into 3 categories of journal IF: high impact (IF 15), high quality (HQ) (IF 5515) and other (IF55). However, this approach overlooked high-quality journals with low IFs, which include critical publications in specialized disciplines. Research design and methods: We solicited suggestions for high-quality journals with IF55 across experts in the AZ core disciplines to include in the publications metrics. These journals are considered to be the primary, highest impact journals for publications in their field. We reviewed and rated each suggestion for inclusion in the HQ list according to pre-established criteria, including number of articles that we published in that journal in past years, target audience, therapeutic area, etc. Results: We received 118 journal suggestions. This exercise was completed over a 3-month period. As a result, we selected 68 journals for inclusion in the HQ list. Conclusions: While impact factor remains a valued tool to evaluate the quality of journals and, by extension, articles published in those journals, focusing on IF alone excludes high-quality journals. Basing publication success and metrics on IF alone can be misleading and overlook important, impactful publications. Avoiding high-risk authors: Should Corporate Integrity Agreements recommend searching the Retracted Publications database? Luke C. Carey, Aruna Seth, Mark Woolley and Karen L. Woolley ProScribe–Envision Pharma Group, Sydney, New South Wales, Australia Consulting Solutions–Envision Pharma Group, Southport, Connecticut, United States University of Queensland, Brisbane, Queensland, Australia University of the Sunshine Coast, Maroochydore DC, Queensland, Australia Objective: Corporate Integrity Agreements (CIAs), which can address authorship practices, typically require sponsors to check if individuals have been debarred, but don't yet recommend checking if these individuals have authored retracted publications. Authors with misconduct retractions can be serial offenders (highrisk authors). We investigated 1) the feasibility of cross-matching debarment and retracted publications lists, and 2) how well debarment searching could detect retracted authors. Research design and methods: For this quantitative and qualitative assessment, we exported (11/08/2015) data from the US Food and Drug Administration (FDA) Debarment List and the MEDLINE Retracted Publications database (both freely ! 2015 Taylor & Francis www.cmrojournal.com Abstract S5 accessible). Every debarred individual was checked against all authors of all retracted publications. Potential matches were further investigated to ensure cross-match validity. Searching time was recorded. A case study was conducted on the cross-matched author with the highest retraction record. Results: Cross-matching was feasible; each debarred author could be checked within 5 minutes. The FDA Debarment List (n = 139 entries; US focus) was less comprehensive than the Retracted Publications database (n = 4013 entries; global focus). There were only 2 (1.5%) matches between debarred individuals and retracted authors; both retracted authors were serial offenders for publication misconduct. The case study showed debarment didn't occur until 2 years after 18 publications had already been retracted. Conclusions: The Retracted Publications database, more global and 30-fold larger than the FDA Debarment List, could provide sponsors and agencies with a free, practical, timely, relevant, and comprehensive way to help avoid high-risk authors. Future CIAs, as well as Good Publication Practice guidelines and company policies, could consider recommending a Retracted Publications search before author engagement. Acknowledgments: The authors acknowledge project management support from Dr Thao Le (Envision Pharma Group). Can Centers for Medicare & Medicaid Services (CMS) reporting verify disclosures? Melanie Blanchard, Gina Fusaro, Jill Sanford, Debbie Wolinsky, Dawn Martucci, John McGuire and Suzanne Van de Water MediTech Media, Atlanta, GA Celgene Corporation, Summit, NJ MediTech Media, Hamilton, NJ Objective: Disclosure reporting is unstandardized. Physician payments are reported to CMS under the Sunshine Act. We compared disclosures with CMS reporting to determine if the database could verify disclosures. Research design and methods: Disclosures from 57 US physicians from 4Q2014 3Q2015 were compared to the 2014 database. Consistency was evaluated in 4 categories: Consultant/advisor, speaker, honoraria, and research. Pearson's correlation was used to evaluate the effect of number of CMS-reported relationships and number of mismatches. Results: 9% of disclosures matched CMS information across all categories. Consistency of honoraria reporting occurred most often (74%); in each instance no payment was reported. The mean number of affiliations per physician was 3.7 by both CMS (range 1–12) and disclosures (range 0–45);


Updated English business correspondence requires a modern and unsophisticated method of expression ranging from the layout to the contents of the letter. It has to be accurate, concise, neat and easy to read. To the reader, the most significance of the contents has to be understandable. The out-of-date style of writing in the 20(superscript th) century is full of long wordiness and too much courteousness. Sometimes it is too vague, ambiguous, and hard to understand. There are a lot of expressions to which the writer should pay attention besides the said obsolete expressions, e.g., the use of inside address, salutation, complimentary close, signature block, initials, carbon (circulated) copy, enclosure, postscript, and layout.


The main ingredients of conventional Supersymmetrical Quantum Mechanics (SUSY QM) are presented. The generalization with supercharges of second order in derivatives - Second Order SUSY - is formulated, and the property of shape invariance is defined. The generalization to two-dimensional coordinate space, after using just these two elements of the modern SUSY QM approach, provides the opportunity to solve analytically some two-dimensional problems. Two different procedures of supersymmetrical separation of variables are formulated. They are illustrated by two-dimensional generalization of the Morse model.


In order to discuss the long-term reliability and safety of zirconium-cobalt alloy for tritium use, the release behavior of decay helium from ZrCo tritide has been investigated for one and a half years with a radio-gaschromatograph. In this paper, the results show that the release fractions of the total decay {sup 3}He in ZrCo tritide are less than 3% and has been almost constant for 18 months under the following conditions: the operating temperatures = 293 {approximately} 523 K, the atom ratios (T/ZrCo) = 0.3 {approximately} 1.4, and the number of hydrogenation-dehydrogenation cycles before tritiation = 1 {approximately} 10. Moreover, residual decay {sup 3}He was not released even if ZrCo was heated to 873 K, though most of the tritium was released. It became clear that the decay {sup 3}He was quite immovable in ZrCo tritide under these experimental conditions.


Book reviewed:

What's Faith Got to Do with It? Black Bodies/Christian Souls, Kelly Brown Douglas, Orbis 2005 (13-978-1-57075-609-2), xix + 252 pp., pb $18.00


Abstract : Most scientific and technical instruction relies heavily on the use of examples and exercises to teach domain-relevant problem-solving skills. Little is known, however, about the relationship between the structure of such curricula and the learning abilities and strategies students must have for effective learning. The research reported here has explored how learning occurs when a student is presented structured sequences of exercises in a teaching situation. The approach has been to develop a computer simulation model of a prototypical student learning how to prove theorems in elementary logic. The simulation is based on an actual computer-assisted instruction (CAI) curriculum of exercises used to teach human students at the university level. The focus in the simulation has been to obtain good performances, in terms of acquiring problem-solving skills, by relying as much as possible on a model of how the student interprets the sequence of exercises in the curriculum. We have identified a small number of principles used in creating such sequences, and have demonstrated algorithms for recognizing the sequences in order to drive the acquisition by the simulated student. The work has implications for the design of computer-based learning systems and models. In addition, the work provides a framework for understanding the incremental development of problem-solving skills in students.


The author analyzes demographic aging in Hungary over the period 1973-1989, then makes projections to the year 2010. The formulas used are included.


The mechanism responsible for the prompt emission of gamma-ray bursts (GRBs) is still a debated issue. The prompt phase-related GRB correlations can allow discriminating among the most plausible theoretical models explaining this emission. We present an overview of the observational two-parameter correlations, their physical interpretations, and their use as redshift estimators and possibly as cosmological tools. The nowadays challenge is to make GRBs, the farthest stellar-scaled objects observed (up to redshift ), standard candles through well established and robust correlations. However, GRBs spanning several orders of magnitude in their energetics are far from being standard candles. We describe the advances in the prompt correlation research in the past decades, with particular focus paid to the discoveries in the last 20 years.


We select a menu of seven popular decision theories and embed each theory in five models of stochastic choice, including tremble, Fechner and random utility model. We find that the estimated parameters of decision theories differ significantly when theories are combined with different models. Depending on the selected model of stochastic choice we obtain different rankings of decision theories with regard to their goodness of fit to the data. The fit of all analyzed decision theories improves significantly when they are embedded in a Fechner model of heteroscedastic truncated errors or a random utility model. Copyright © 2009 John Wiley & Sons, Ltd.


The present study investigated the acceptance of e-banking services by customers using Technology Davis's Acceptance Model proposed (ATM). In this study, the descriptive and correlational research method was used. Statistical population of the study included all clients who had a bank account at Mellat Bank in Jahrom city, Fars, Iran. Simple random sampling was conducted by selecting 200 customers of the Mellat bank branches. For data collection, a questionnaire was distributed among the participants and Pearson's correlation test was used for data analysis. In this study, the effects of variables of perceived usefulness, perceived ease of use, perceived risk, computer selfefficacy, quality of the Internet and Internet access, on e-banking adoption by customers was examined. Findings showed that factors of perceived usefulness, ease of use, and quality of Internet had the greatest impact on the acceptance of e-banking services by customers.


Numerous articles have been published regarding the strained relationships between highly involved export manufacturers and their international intermediaries. While channel conflict is frequently cited as a major reason for such strained trade relationships, few research studies examine the relationship between a manufacturer's export involvement and channel conflict. In this paper, we develop hypotheses linking the three major domains of export involvement to the initial stages of channel conflict. The results indicate that a manufacturer's conflict with its principal international intermediary decreases with greater manufacturer dependence on the principal intermediary, increases as resources are committed to exporting, and decreases with the manufacturer's foreign market knowledge.


The present invention relates to a medicinal liquid injection device which is configured to simply grasp whether a needle mounted on a needle holder is inserted into a patient by allowing a needle holder to slide at a time and by sensing whether the needle is adjacent to the needle through hole. The medicinal liquid injection device comprises: a casing having a needle penetration hole; a button exposed to the outside of the casing; a needle holder; a sensor located in the casing, and provided to sense whether the needle holder is adjacent to the needle penetration hole; and a controller electrically connected to the sensor.


The present invention relates to a probiotic including the B cell-mediated autoimmune disease is Myasthenia gravis microbes for the prevention, improvement or treatment, as an active ingredient. The compositions of the present invention generates the control dendritic cells (regulatory dedritic cell) and, acetylcholine receptor-inhibit reactive lymphoid hyperplasia, blood anti-by reducing the acetylcholine receptor immunoglobulin G (IgG) and / or the inflammatory cytokine levels B-cell mediated autoimmune diseases and treatment of myasthenia gravis. The compositions of the present invention can be provided because of the use of a microorganism strain is harmless to the human body, a safe medicine or food.


For each of the last twenty-eight years, the findings of the Annual Phi Delta Kappa/Gal lup Pol l of the Publ ic ' s Attitudes Toward the Publ ic School s have been shared w ith professional educators and the general publ ic . In this series of annual polls, the Gallup Or ganization uses its standard national telephone sampl ing procedures so that the distribution of the sample matches current estimates derived from the U .S . Census Bureau ' s Current Populat ion Survey for the adult populat ion l iving in telephone households in the conti nental U .S . Using these scientific sam p ling procedures, the pol l provides ac curate and balanced information that can be used to decide what the future of the publ ic schools w i l l be. One of the most w idely referenced findings of this national pol l has been a rank ordering of responses to this question asked in each of the past twenty-eight years : What do you think are the biggest prob lems with which the public schools in this community must deal? To encourage school districts to compare and contrast national po l l findings w ith actual problems encoun tered in local school districts, the Gal lup Organization has made their entire questionnaire item bank and the corre sponding survey research procedures avai lable to educators who wish to rep l icate all or any part of the pol l in the ir own school districts or communities (see Note l ) . Local school district repl ications of the Annual Gal lup Pol l of Pub l ic Edu cation (a shortened title to be used in the balance of the article) c learly a l low both professional educators and the pub l ic to recognize if one or more of the problems documented in the national pol l exist in their community. I f these problems do exist, local rep l ications also al low stakeholders to compare the magnitude of these problems at the lo cal level to the corresponding magni tude indicated for the nation at large. It has been my experience that sur vey findings from an accurate and t imely local repl ication of the Annual Gal lup Pol l of Publ ic Education can help prevent a local community from falsely conc luding that the b iggest na tional problems automatical ly exist at the same magnitude in their school dis trict. An example may help to c larify the advantage of a local repl ication. From 1 969 to 1 985 every Annual Gal lup Pol l of Publ ic Education but one ranked lack of discipl ine as the top problem . Yet two local school d istrict rep l ica tions, conducted as part of two separate five-year strategic p lann ing surveys, fai led to reach the same conclus ion. This was due in large measure to the fact that th is school district had in place a very effective discipl ine management program. With these ideas in m ind, the pur pose of this article is to share the findings of a comparative analysis of the "biggest problems" question which was used in both the 1 996 Annual Gal lup Pol l of Pub l ic Education and a 1 996 five-year strategic planning survey conducted in a s ingle publ ic school dis trict. Th is intent i s accompl ished by an swering four specific research ques tions. These are (I) What were the 1 996 Annual Gal lup Pol l of Publ ic Educat ion national findings on the "biggest prob lems" question? (2) What were the lo cal school district findings on th is same question? (3) What differences exist in the findings of these two surveys? ( 4) What spec ific advantages and key in s ights accrue to a local school d istrict that e lects to repl icate the "biggest problems" question in their own survey of adu lts residing in their community? Us ing these questions, the balance of the article is div ided into four parts, each part providing an answer to one of these questions.


The article tackles the issue of conceptualization on the basis of the category REAL ESTATE in the Anglo-Saxon culture. The paper is an attempt to reveal the structure of the mental object from the complex position. The category REAL ESTATE is presented by 22 concepts. The category members include explicit and implicit attributes. We assume that the complex analysis of the mental object makes it possible to reveal the structure of the above category in a more complete way. It also throws the light on the role of real estate in the Anglo-Saxon culture and peculiarities of its conceptualization.


In his book titled Humanities:a Re-Interpretation of the Relation between the History of Literature and the History of Thoughts,Mr. Zhang Bao-ming puts forward an argument of the relation between the history of literature and the history of thoughts integrated with humanities,which embodies a valuable exploration and innovation. But,at the same time,some of his viewpoints seem too radical and illogical,especially about classic literature. They are as follows:(1) Confusing academic concepts,for example,about the interpretation of the "humanities" and "thought",and making a meaning choice according to his own needs.(2) No criteria about making a point,and being unable to decide which is right. For example,using the relation between the history of literature and the history of thoughts to approve modern literature,and using the link between the two to negate classic literature.(3) Ignoring the facts and thinking him always right. For example,using the so-called modern thought under the standard of the May 5th Movement to negate the ideological level of classic literature,which is neither realistic about classic literature nor consonant with the attitude of the May 4th intellectuals towards classic literature.(4) Being self-contradictory and over-extended. For example,from the perspective of universal humanity,connect the history of literature with the history of thoughts,considering that both have "universal" and "natural" link. Since the link is "universal" and "natural",why not to include classic literature? Faults such as these are everywhere. Therefore,Li Han' s essay is written so as to discuss with Mr. Zhang.


The sixth article in a series that will explore traditional games takes a look at an activity that has been around in one form or another since Roman times–this month, we ask you to hop, skip and jump!


The paper suggests several ways how to combine a genetic algorithm with integer programming to improve the quality of the problem solution. The motivation is that today's integer programming solvers are very sophisticated and efficient and they are worth utilizing in combination with metaheuristics to solve hard combinatorial optimization problems. The capacitated p-median problem is chosen as an example of such a problem that is intractable for an exact method and needs a heuristic or metaheuristic method, e.g. a genetic algorithm to get a near-optimal solution. A genetic algorithm can be combined with integer programming in such a way that the metaheuristics acts at a higher level and controls the calls to the solver. The solver can be used for: (i) fitness calculation, (ii) improving the best solution, and (iii) generating elite solutions. Several variants of the hybrid genetic algorithm are proposed and tested using benchmark instances.


1. Introduction, Stephen Aris Part I: Africa 2. The Security Culture of the African Union, Paul Williams 3. Security Regionalism in West Africa: Conceptions and Practices, Helene Gandois 4. How much its own and to what end? SADC and the culture of security and regional organisation in Southern Africa, Paul-Henri Bischoff Part II: (South) East Asia 5. ASEAN as a Regional Organization: Security Conceptions and Practices, Anja Jetschkev 6. The Evolving New Security Agenda in East Asia's Regional Affairs, Christopher M. Dent Part III: Middle East 7. Security Conceptions and Practices in the Middle East: The Case of the Arab League, Raymond Hinnebusch Part IV: Eurasia 8. The Shanghai Cooperation Organisation: A Eurasian security actor?, Stephen Aris 9. The Collective Security Treaty Organization: A Multilateral Response to New Security Challenges?, Katharina Hoffmann Part V: South America 10. UNASUR and Regional Security in South America, Detlef Nolte and Leslie Wehner 11. Articulating Mercosur's security conceptions and practices, Andrea Oelsner Part VI: Regional Organisations in Comparison and Global Security Management 12. Regional Organisations in Security and Governance, Emil Kirchner and Roberto Dominguez 13. Conclusion, Stephen Aris and Andreas Wenger


CD66a is an adhesion molecule member of the carcinoembryonic antigen immunoglobulin‐like family present on the surface of epithelial cells, granulocytes and IL‐2 activated T cells. We studied whether CD66a is expressed in vivo by T lymphocytes and whether it affects TCR‐mediated activation. CD66a was detected by histochemistry, flow cytometry analysis, reverse transcription PCR and Western blot on fresh colon biopsies and T cell clones. A fraction of T cells in the lamina propria express CD66a, which is induced by IL‐7 and IL‐15 cytokines. T cells express four different CD66a splice variants and at least two forms of the protein are glycosylated in a cell type‐specific manner. Triggering of CD66a on T cells with physiological ligands or with specific mAb increases TCR‐mediated lymphokine release, in an antigen dose‐independent manner. This effect requires the presence of the CD66a intracytoplasmic domain, which contains two immunoglobulin receptor family tyrosine‐based inhibitory motif‐like domains, as shown by stimulation of Jurkat cells transfected with different CD66a isoforms and is associated with increased induction of AP1 and NFκB transcription factors. These data indicate that CD66a amplifies T cell activation and thus could facilitate crosstalk between epithelial cells and T lymphocytes in intestinal immune response.


We have experimentally demonstrated up to 20-fold compression and transform-limited spectral broadening of pulses generated in a synchronously pumped optical parametric oscillator (SPOPO). We have also developed a model of an SPOPO with pulse compression. Our model shows the compression to be due to group velocity walk-off combined with parametric gain depletion. We find excellent agreement between our model and the experimentally observed behavior of our SPOPO, including the prediction and observation of up to 20-fold compression. We discuss possibility of generation of the shortest pulses with highest possible contrast.


At present the only way that will lead the company to success in the global market within the framework of free competition is to be or become an innovative company in the whole process of development, production, sales, implementation and use of products. This basic assumption of success of the industrial enterprise is based on specifications of business markets and places, strong demand for differentiated approach to individual firms/customers. Findings that are used in this paper are mainly obtained by secondary research methods, analysis of actual data from relevant sources and insights of individual personal interviews with representatives of metallurgical companies. In terms of the used methodology the most appropriate proved to be the method of cluster analysis for selected indicators which helps to identify the interdependencies. When summarizing the outcomes of the individual analysed areas the method of synthesis was used.


A second light-shielding pattern, according to one aspect, is formed in the first direction perpendicular to the second direction on the first light-shielding pattern and the first light-shielding pattern formed in the first direction on the base substrate, the base substrate of the present invention the panel that is provided. A black matrix, a color filter, a printing method, a pattern transfer, gravure printing


This paper focuses on the WSRF (Web services resource framework) framework and its realiz- tion in Globus Toolkit 4.Through the concrete example,it provides the process that consturcts the WS- Resource based on WSRF and discusses the pattern of publish/subscribe messaging.


DOI: 10.21276/sjebm.2018.5.12.9 Abstract: All the institutions operating in the sports field have to move into Total Quality Management in order to offer better services to their stakeholders. This transition becomes a must for the sports institutions in our country, due to their lack of efficiency resulting from not working with modern methods. Sports clubs that embrace this approach can improve their service quality by improving their vision, mission and values. Success of implementation of a quality management system depends on the support from management and teamwork which involves all the employees. In this study, application of Quality Management System will be analyzed in sports club "Bursaspor" along with the quality of service that the club provides.


A thermal neutron detector based on ZnS(Ag)/6LiF scintillator, wavelength- shifting fibers (WLS) and silicon photomultipliers (SiPM) is under development at the Paul Scherrer Institute (PSI) for upgrading the POLDI instrument, a pulse-overlap diffractometer. The design of the detector is outlined, and the measurements performed on a single channel prototype are presented. An innovative signal processing system based on a photon counting approach is under development. Its principle of operation is described and its performances are evaluated on the basis of a Monte Carlo simulation.


ABSTRACT This study was an action research aims to study the effect of schizophrenia patient management in community between 10 October 2009 – 10 January 2010 by selecting 7 schizophrenia patients in Tha Khantho Hospital Kalasin Province. Data were collected by questionnaire and schizophrenia patient efficiency evaluation. Data were analyzed by descriptive statistic namely percentage , mean and standard deviation and content analysis. Result : 7 schizophrenia patients care were as the followings, 2 patients of condition level 1 , 4 patients of condition level 2 and 1 patient of condition level 3 after care finding ; Level 1 : 2 patients had better condition than more before came to level 3 by self care Level 2 : patient had better condition than before came to level 3 by one 's daily tasks self care. Between care nothing found alcohol beverage used in the patient of alcohol beverage problem moreover they could work job to earn for family.  Level 3 : scores of the patient are more and more. Living together with family and society better.  No drunk alcohol drunk beverage between study. They could work to earn for their families. Keyword : schizophrenia patient


This study generally intends to analyze perception of remuneration justice from the perspectives of stakeholders in Indonesian Public Islamic Universities (PTKIN) that have acquired BLU status. Specifically, this study aims to measure the level of distributive and procedural justice on the implementation of remuneration at selected PTKIN. The respondents of this study are the beneficiaries and remuneration policy makers from 11 PTKIN that have implemented and paid the remuneration at the time of the study. Additional data are obtained from interviews with nine policy makers from the selected PTKIN. The data are analyzed using descriptive percentages method. The results show that in general the implementation of remuneration at the selected PTKIN in included within "fair" category as perceived by the stakeholders. Partially, respondents perceive procedural justice as "tend to be fair", while distributive justice is "fair". This shows that in terms of procedures, the selected PTKIN still have to work harder to fulfill a sense of justice, while from the distribution side it has given more sense of justice as perceived by most respondents.


The concepts of "equity" and different types of distributional concepts are defined and their implications for transport policies indicated. In conclusion it is argued that the proper role of the policy analyst is to identify the prospective losses and benefits and evaluate the costs of alternative solutions as a part of the policy development process. (Author/TRRL)


The design constraints required to achieve single-longitudinal-mode operation from a standing-wave, homogeneously broadened, three-level, fiber laser which utilizes intracore Bragg reflectors for cavity feedback are presented. In particular, a closed-form solution to the laser rate equations is found which bounds the region in which only single longitudinal mode operation is supported. The principal resonator geometry to be considered is a two-reflector cavity which utilizes only Bragg reflectors for feedback. Analytical and experimental results are discussed. >


This paper develops a discrete time version of the continuous time model of Bouchard et al. [J. Control Optim., 2009, 48, 3123–3150], for the problem of finding the minimal initial data for a controlled process to guarantee reaching a controlled target with probability one. An efficient numerical algorithm, based on dynamic programming, is proposed for the quantile hedging of standard call and put options, exotic options and quantile hedging with portfolio constraints. The method is then extended to solve utility indifference pricing, good-deal bounds and expected shortfall problems.


AOMD is an Open Access journal with no charge for submission, processing, or publication of manuscripts. The scope includes original research articles, review articles, brief communications, case reports, and letters to the editor covering Clinical, Paraclinical, and Basic Sciences relating to movement disorders. The journal will also support online submission of high-quality videos. All articles in AOMD are peer reviewed through a blinded methodology to maintain the standards of the journal. The current plan is to release three publications a year online and in print.


The demographic characteristics of serial offenders that distinguish between the commuter and the marauder offence styles were examined. Proposed by Canter and Larkin (1993) these two styles represent competing models of criminal spatial behaviour under which the home base plays a role in offence site selection. Data on serial burglars, arsonists and sex offenders were extracted from the criminal records maintained by the NSW Police Service. The offence style of each offender's crime series was identified in order to relate the offence style to the demographic variables, and to examine the offender's first and last offences in a series. A commuter offence style was more likely to be adopted by burglars and generally by adult males. A marauding offence style was apparent in sex offenders and metropolitan based offenders. There was a progression in the distance travelled to offend across all crime types, as the last offence was located further from the home base by comparison with the first. These findings serve to validate the conceptual distinction between commuter and marauder offence styles. Several implications for further research are addressed. Copyright © 2004 John Wiley & Sons, Ltd.


Ultrasonic and microwave techniques were applied in combination to the extraction of traces of polycyclic aromatic hydrocarbons(PAHs) from soil sample using mixture of n-hexane and dichloromethane(1+1) as solvent.The extract,after dehydration and concentration,was used for GC-MS determination of the PAHs.When the moisture content and inorganic salt content of the soil sample were 10% and 6% respectively,and under working conditions of ① using 40 mL of the mixed solvent,② power of microwave radiation 100 W,③ power of ultrasonic vibration 50 W and ④ time of extraction 9 min,the recovery obtained in the analysis of simulated samples attained to 86.9%,and average values of RSD′s(n=5) found was 3.6%.As compared with several other methods of extraction,including the soxhlet extraction,open or closed vessel microwave assisted extraction and direct or indirect ultrasonic agitation extraction,the present method was proved to have higher capacity and efficiency as well as better repeatability.


Many Regionals Government in Indonesia still rely on DAU allocations to finance regional expenditures and development without optimizing the potential of the regions. When DAU allocation obtained is large, the regions will try to keep DAU in the next period at the nominal value. PAD is able to finance local government at a maximum of 20%. This fact has led to asymmetrical behavior in local government. The regional government responds to the transfer of funds in the form of balancing funds, especially DAU which is realized in the regional budget. As regional spending is greater than the transfer, it is called the flypaper effect. The method used in this research is descriptive quantitative analysis method using panel data regression. The data analysis with regression uses the Eviews 9.0 program. The data used in this research use panel data with independent variables, namely General Allocation Fund (DAU) and Regional Original Revenue (PAD). The dependent variable is Regional Expenditure. The results of this study are: 1) General Allocation Funds have no effect on Regional Expenditures; 2) Regional Original Revenues affects Regional Expenditures; 3) General Allocation Funds and Regional Original Revenues simultaneously affect Regional Expenditures; 4) There is no Flypaper Effect in Regency/City Government of Lampung Province 2016-2019; 5) Regional Expenditures of Lampung Province is not compatible with the Islamic economic perspective.


Sickle cell anemia is one of genetic diseases caused by hemoglobin biochemical disorder in especially in polypeptidic chain of this protein. The study was conducted from October 2019 to December 2020 and included two sets of samples Patient and Healthy .The current study was curried out to evaluate some enzymes and trace elements in patients with sickle cell anemia. The levels of copper (Cu) were estimated spectrophotometrically by reaction of copper with 4 – (3,5 – dibromo – 2- pyridylazo) – N – ethyl sulphopropylaniline to produce a chelating complex.The determination was carried out at wavelength equal to 520 nm. Finally, absorbances were recorded and they are proportional to concentration of copper in the sample . Also, the levels of zinc in serum of blood belonging to sickle cell anemia (SCA) were investigated and estimated by reaction of zinc with chromogen existing in the characteristic kit to produce coloured complex. The absorbances were recorded spectrophotometrically which are proportional to concentration of zinc in blood sample . The levels of biochemical variables were estimated using ARCHITECT c4000 systems provided by ABBOTT Company, which are designed with advanced technology, accuracy in clinical results and ease of handling. The device uses a sample size at a rate of 6µL in all measurements of chemical variables.The total values of the current results were made and expressed by calculation of the mean ± standard deviation. Analysis of all results data were  carried out by using a statistical procedure according to analysis of variance univariate . Statistical programmer of social science  (SPSS ,v.23 ) was depended for calculation of significant differences for the different groups of patients infected by SCA disease and healthy persons . The correlation regression coefficient (r) was used and depended to distinguish between the means of groups belonging to all patients and healthy individuals ( control group ) .The p-value was agreed for less than 0.05 to the limit of lowest significance . A highly significant difference was recorded belong to levels of GPT, ALP and GOT in patients compared with healthy individuals (control group) according to age and sex factor.


A 23 year old woman was referred to Queen Elizabeth Central Hospital (QECH) from Thyolo District Hospital with a 15 year history of persistent post-prandial vomiting. She had associated dysphagia to solids and liquids, heartburn and weight loss, without nausea or change in appetite. Two weeks prior to referral she gave birth to a premature live infant. Her symptoms worsened significantly during the pregnancy. Previous presentations to her local health centre had resulted in advice to improve her nutritional status only. This was a single mother with no psychiatric history.

On admission she was cachectic with ketotic breath. She was apyrexial and hypotensive with a blood pressure of 90/50 mmHg. Her weight was 34kg and height 1.55m (BMI 14.2). On inspection she had dry mucous membranes, pink conjunctivae and clear oral cavity. There was no oedema or jaundice. Cardiovascular, respiratory, neurological and abdominal examinations were normal. First impressions were severe malnutrition and hypotension, for which immediate fluid resuscitation and antiemetics were commenced.


A qualitative and quantitative analysis of D-mannitol from Cistanche deserticola was conducted by using infrared spectroscopy and spectrophotometry,D-mannitol extraction process was also presented.Through crystallization method,the white powder of D-mannitol crystal from Cistanche deserticola was obtained,and its obtaining rate reached to 2.9%.


Preface. 1: Introductory Considerations. 1.1. The impasse. 1.2. What might the claim that there 'are' nonexistent objects mean. 1.3. Methodological concerns. 2: Meinong's Theory of Objects. 2.1. The Independence and Indifference principles. 2.2. The Independence principle: initial reaction. 2.3. The Indifference principle: initial reaction. 2.4. Is there a third mode of being? 2.5. Meinong and his historical precursors. 3: The Nature of Meinong's Objects: Existent and Nonexistent. 3.1. Incomplete objects and the nature of existents. 3.2. Incomplete objects and the nature of nonexistents. 3.3. More on the particular-general and concrete-abstract distinctions. 4: Two Main Arguments for Nonexistents. 4.1. The argument from negative existentials. 4.2. The argument from intentionality. 5: Main Arguments against Nonexistents. 5.1. Definitions of object-possiblity and object-impossibility. 5.2. Theories of nonexistents are inconsistent or apt to infringe the law of non-contradiction. 5.3. Nonexistent aren't objects. 5.4. An existence objection. 5.5. There are no impossible worlds or individuals. Bibliography. List of Meinong's Writings Consulted. General Bibliography.


II. Excisiont of the Joint. *This operation lhas not been muclh in favour at tlhe hospitals in Rouen; at some it has not been resorted to at all, but I have collected forty-two cases. Of these, eight were followed by amputation, and tlle deatlhs, either with or witlhout amiputation, wvere thirteen. I do not regard tllis as a fair picture of wlhat may be obtained by excision. In some cases I am satisfied tllat excision was resorted to at too late a staae, in thle lhope of escapina from the disagreeable alterniative of amiiputation-a hope whiclh wasfrustrated later on, amiputation then being performed in patients wlho were ill able to witlhstand a further severe traumatism. If we are to consider excision at all it must not be as an alternative to amputation; tllere is a case to excise and there is a case to amputate, and these must not be confused. Oine of the really difficult tasks wllich a surgeoni hias to undertake if he adopts excision is to select suitable cases. Some of tlle results recently reported of early excision tempt one to adopt that line of treatmuent, but it will be well to remember before doing so whlat our own experience has tauglht us, that a large number of suclh early cases recover under conservative treatment, and witlh useful joint function in somUe instances. Anothler point wllich makes one lhesitate is the lack of knowledge of the final utility of the excised limb. Onie metlhod suggested in a recent paper involved a wide separation of the divided bones of about two inch s, and the bone ends being maintained apart until all sepsis hiad disappeared. From the experience of excision of the knee in civil practice failure of bony union is under these conditions likely to occur, and the union by fibrous tissue may be very unstable. Firm union after excision lhas always appeared to me to depend nmainly on early and accurate approxinmation of the sectioned bones. If bony union fails, furtlher operative measures, by freshening of bony surfaces or bv bone grafting, may yet succeed, but eveni if they do they involve for the patient the anxiety of a further operation, a rather prolonged convalescence, and possibly further shiortening of an already slhort limb. Conviction as to the value of excision of the knee will only arrive wlhen we know the final results obtained. To sum up tllis question of excision, if we excise very early we may get immediate satisfactory results, but we do not know what the final results will be, and we slhall be excising joints which in a considerable nLumber of cases may recover under conservative treatment, some with useful movement. If we excise in a later period we encounter a considerable deatlhrate, a high amputation rate, and uncertaintv as to the final utility of the limb in the remaining cases.


We propose a novel, hybrid optical-electronic switched network architecture with flexible bandwidth provisioning for scaling the capacity of the upper tiers of next generation datacenter and high-performance computing (HPC) networks. The network combines transparent optical packet switches, based on Arrayed Waveguide Grating (AWG) routers, and a deflection routing scheme to alleviate packet buffering requirements in the optical domain. Through simulation studies we show that, coupled with a dynamic switch-port bandwidth provisioning and load balancing scheme, the network can maintain high performance under changing traffic loading.


Persons are sexed beings and for this reason we must know how to cope and live our human sexual fact. This requires a learning based on the different social agents, especially, family and school. So that people's sensitivity are not hurt, it has to be defined concepts, to be known myths, stereotypes and prejudices that are very varied in this issue. The proposed activities for the classroom –opinion, reflection, research and entertainment summary- take part in the magazine's whole structure, dedicated to adolescence and sexuality. The activities –from an active methodology- make reference to express opinions and feelings about sexuality, to define concepts, to know myths and stereotypes about sexuality, and lastly to have a reflection about the different situations of the human sexual fact.


Ultrasound (US) or Sonography is a primary adjunctive breast cancer screening modality to mammography. It uses ultrasonic waves for diagnosing an internal body structure, comprises of non-harmful radiation with a frequency range of 1MHz to 15MHz. It determines whether the area under consideration consists of a dense tissue or not. In addition, Ultrasound imaging can be made from any angle or orientation. Diagnosis using ultrasound is noninvasive, it is also safe and it does not have any cumulative biological side effects. Mainly, strength of this imaging technique is low acquisition time and relatively inexpensive. Ultrasound images are used to evaluate lumps that are hard to see on a mammogram. According to Szabo [139], ultrasound leads the imaging modalities worldwide after the standard X-ray exams. Moreover, the better understanding of the ultrasound interaction with tissues and the usage of more sophisticated signal processing algorithms, increase the diagnostic potential using ultrasound.


Custom banquet is an important matter in social life in Zhuang village in Nandan, Guangxi province.It hasn't been obviously changed on the surface for thousands of years.However, there are lots of changes in its intrinsic nature. The article analyzes the inheritance and vicissitude of the custiom from the area of Ethnology and Social Anthropology.


The authors of the article take an attempt to clear up the meaning of the authentic religiousness that escapes from our attention in the dictates of confessional dogmata. The authors argue that the recultivation of re-ligio in the domestic culture was started by the Silver age aesthetics, mainly by poetry. The latter in its turn paved the way to the elusive existence by using of the revived word of the language as a natural element.


Nowadays, multi-sensor networks are evolving into large scale networks with limited bandwidth and energy reservoirs. Hence, reducing the number of information exchanges among the sensors is an efficient approach to meet the stringent requirements of bandwidth and energy in the context of multi-sensor state estimation. In this paper, a surprisal-based multi-sensor information filtering is proposed to allow on average a desired number of sensors with most informative measurements to participate in the information exchange, while discarding the sensors with non-informative measurements and outliers. The concept of surprisal is used to facilitate the sensors in the network to independently classify their measurements as informative, non-informative and outliers by setting upper and lower thresholds. Simulation results show that the proposed scheme ensures that on average only a desired number of sensors with the most informative measurements participate in the information exchange and achieves greater estimation accuracy compared to the method, where the sensors are selected randomly for the same number of transmissions.


Flash photolysis of bis[piperidyl-1] disulfide gave a clear transient band at 340 nm and a weak band around 525 nm, which were assigned to the piperidyl-1-thiyl radical. In a similar manner, bis[di...


ABSTRACT:The common goal of both historical and animist materialism is the re-enchantment of the world. To realize this goal, contemporary African literature must do more than simply represent the world. Its most vital role is to perform itself as a surrogate rite of re-ancestralization, one that engenders a radically expanded, trans-species spirit of relatedness. Chris Abani's 2007 novel Song for Night is an exemplary allegorization of this expansive process of re-ancestralization in that its narrator, blown apart by a landmine, must reinvent his Igbo grandfather's forgotten song of connectedness in order to rejoin the world of the ancestors. Insofar as his lyrical song for night transposes the improvised sign language of his platoon of muted minesweepers, the narrative mimes their creative resistance to the instrumentalization of human life. However, this creativity does not constitute a recovery of the human so much as a spirited affirmation of corporeal similarity, or what I term creaturely mimesis.


The aim of this study is to examine the aims of the Kanal Istanbul Project with Gee's critical discourse analysis method. According to Gee's Critical discourse analysis method, language has seven functions such as giving (not) importance, introducing practices, creating identities, establishing relationships, policy (distribution of social goods), connections and sign information systems. In addition, there are six tools for revealing these functions, such as social languages, intertextuality, speeches, discourse, positioned meaning and figured worlds. This study is based on the 'Connections Building' function, one of the functions of language, and the 'Figured Worlds' tool from the tools. In other words, in the text to be analyzed, the connections building function of the language has been tried to be revealed through figured worlds. The subject of the study is the Kanal Istanbul Project; method is Gee's critical discourse analysis method. The importance of the study is to bring Gee's analysis method to the national literature in detail, to exemplify how to apply this method with the Kanal Istanbul Project and to analyze the text with the aims of the project in terms of the connections building function of the language. As a result of the study, it was concluded that with the Kanal Istanbul Project, many events, situations, subjects and scenarios have a function of making connections between figured worlds and language. These connections are detailed in the analysis and conclusion sections.


To detect the edge of object, an efficient scheme based on the Multi-Oriented Local Energy (MOLE) is presented. The MOLE is constructed by Multi-oriented Gaussian second differential and its Hilbert transformation. The Multi-oriented Gaussian second differential is obtained by using a linear combination of basis filters with arbitrary orientations. To overcome the affection of illumination, Phase Congruency is employed by normalizing the directional energies. At last, our method is compared with other common methods. The experimental results reveal that this method can extract more continuous edge and obtain more details.


Analysis had made of the precipitation′s electrical specific conductivity (atmospheric precipitation had fallen in Tver in 2016–2019 years). Time series models of the electrical specific conductivity and her evolution were examined. Cubic model has considered as adequate.


A high-pressure cutting fluid guide apparatus of a turret head of a machine tool is provided. When a high-pressure cutting fluid is input to a cutting liquid passage, the high-pressure cutting fluid flows along a through hole of a water guide cylinder, and passes through a main perforation of a partition, and then flows to a water outlet of a sealing ring to be guided into a water inlet of a cutting disc. A secondary perforation of the partition guides the high-pressure cutting fluid in the through hole to a press surface portion of the sealing ring. The sealing ring is located in an annular trough, and the press surface portion is pushed by the high-pressure cutting fluid pressure to generate the energy of the axial displacement.


The paper is mainly about the investment by cash flow. According to investment method, the paper divides the investment into four parts: cash outflows from direct investment, cash inflows from direct investment, cash outflows from indirect investment, cash inflows from indirect investment. The paper uses the four indexes as the proxy variable to describe the expanding and shrinking of the cash flow from investment. What's more, the authors study the influential factors of Chinese listed companies' investment by autoregressive distributed lag model. The empirical study shows that the internal and external factors have different roles in the investment decision making. At the same time, the cash flows from investment have inertial character.


A simulation system is introduced to improve production on older EB reactors and styrene plants to compete with the latest styrene processes such as the Monsanto process. A simulation model of ethyl benzene styrene process flow was built and tested and is schematicized. Each tower, the EB reactor, the PEB recovery tower, and the benzene-toluene separator are specified. Sloppy design in the lumping of described components is eliminated. An integrated reactor fractionation system with EB reactor and styrene process units is created.


We develop a tractable and portable method for characterizing the solution to dynamic multivariate rational inattention models in linear quadratic Gaussian settings. We apply our framework to propose an attention driven theory of the Phillips curve, the slope of which is endogenous to how monetary policy is conducted. We show that the Phillips curve is flatter when the monetary policy is more hawkish: rationally inattentive firms find it optimal to ignore monetary policy shocks when the monetary authority commits to stabilize nominal variables. Moreover, we show that an unexpectedly more dovish monetary policy leads to a completely flat Phillips curve in the short-run and a steeper Phillips curve in the long-run.


Objective:To report the different experience in treating different types of ventricular arrhythmias with radiofrequency catheter ablation(RFCA). Method:The 50 cases of ventricular arrhythmias patients,consisted of 20 males and 30 females,aged(43.21±13.31) 14-70 years.Except 1 case of old myocardial infarction coronary artery bypass grafting(CABG) and the persistent VT,5 cases of ARVC,the remaining 44 cases of ventricular arrhythmias patients confirmed that no device such as the quality evidence of heart disease.The 43 non-organic ventricular tachycardia and PVC's pacing and agitation with traditional mapping.Six cases of organic heart disease and one case of multi-source VT premature ventricular contractions in non-contact mapping system EnSite3000 under the guidance of ablation. Result:①Forty-eight cases with ablation success,two cases of failure;the success rate was 96%,4 cases of recurrence.②RVOT origin of VT and PVC have the typical ECG features,showing typical left bundle branch block model with the right axis deviation.If RVOT origin was different,the characteristics of their 12-lead electrocardiogram were different.Ⅰ,Ⅱ,Ⅲ and aVF,was RR 'type,V1-V3 with deep S wave was the features of the origin from the free wall.ARVC showed typical left bundle branch block type with the right axis deviation,V1-V3 T wave was shallow inversion with sinus rhythm,and the right ventricular wall motion decreased by cardiac magnetic resonance imaging or echocardiography.③One case of ARVC and one case of postoperative CABG patients with old myocardial infarction occurred ventricular fibrillation during the process of ablation,and the ablation continued after electrical defibrillation,which was successful finally. Conclusion:RFCA is a safe,effective treatment.EnSite3000 non-contact mapping system is fast and accurate in positioning for ARVC,myocardial infarction ventricular tachycardia and other arrhythmias combined with hemodynamic instability in the complexity of multi-origin mapping of ventricular arrhythmias.


Recovering the epipolar geometry of a stereo image pair is important for many computer and robotic vision systems, for performing motion recovering, 3D reconstruction and, more recently, image retrieval from large databases. Most state-of-the-art methods for estimating the fundamental matrix rely solely in putative image correspondences, and, therefore, heavily depend on the capability of the low-level image features to provide enough distinctiveness capabilities for establishing correct matches. In this paper we present a robust method for estimating the fundamental matrix based on all image features, and not only matching points. This is done by selecting the best correspondent keypoints between views through a proper weighting function that fuses local appearance of keypoints and distance to the epipolar lines. Several distance weighting functions are compared, with an intuitive theoretical analysis of the role of each function parametrization being analyzed. Experimental evidence shows that our approach outperforms the current state-of-the-art methods in terms of error magnitude, number of correct matches provided and computational time.


Graph spaces provide a setting alternative to Sobolev spaces and BV spaces, which is suitable for the analysis of first‐order linear boundary value problems such as Friedrichs systems. Besides investigations of the well‐posedness of the continuous problem there is also an increasing interest in the error analysis of finite element methods within a graph space framework. In this text we elucidate various methods for an explicit representation of dual spaces of graph spaces. (© 2006 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)


Over 80 excavation rigs are working on the inner ring road project in Madrid, Spain. The project, known as Calle (Street) 30, involves 56km of tunnels. Western and southern portions present geotechnical challenges with the western section crossing beneath the River Manzanares several times. Cut and cover tunnels involved extensive piling, underpinning of historic bridges and modification of foundations. Half of the river width was temporarily infilled with alluvial material to provide a work platform. Thick diaphragm walls were installed to depths of 11-32 m in the river bed. Where the three-lane route passes directly beneath one of the piers supporting Madrid's Segovia Bridge, a jacking system is being used to prevent subsidence. Details are given of the construction processes involved in both tunnelling sections. Twin bore tunnels are being constructed at the southernmost point of the ring road to free one of the busiest road junctions in Spain. Tunnel boring machines have been used to tunnel through the sands and gravels beneath Madrid's Crystal Palace.


PURPOSE: An AT(Authoring Tool)-based electronic book publishing method and a system thereof are provided to let an author correct and edit the contents of a book by using a web-based AT and to process the contract for publishing by calculating a royalty of the corrected book in proportion to quotas of respective authors. CONSTITUTION: The server(101) in the electronic book publishing system has a web-based editing module(103) and a publication processing module(105) and includes a web document(107) transmitted to a web browser. The authors(125,129) write and correct a book by using the web-based editing module, the publication processing module, and the web document. A user(133) makes inference to registered books and reads the contents of the books. A database server(109) connected to the server includes a member information database(111), a book information database(113), and a book use information database(115). The contents written or corrected by the authors are transmitted to the server via a network. The editing module discriminates the original part from the corrected part. The publication processing module calculates a royalty in proportion to quotas of respective authors and processes work related with publication.


A novel algorithm called Cooperative Binary Iterative Hard Thresholding (CB-IHT) based on distributed 1-bit compressive sensing is proposed in this paper. Taking advantage of the correlated nature of distributed signal processing, the proposed algorithm is aimed to fight against the error floor in the estimation of distorted sparse signal, with an array of agents recovering the target signal cooperatively. The principles of convex optimization, consistent reconstruction and greedy pursuit algorithm are combined in the algorithm design. With two joint sparsity models representing distortion of equivalent parallel AWGN channels and parallel fading channels separately, the algorithm is performed through extensive simulations, which show that with severe distortion and large bit-budget, estimation accuracy can be improved by simply increasing the array scale.


The international cruise industry has consistently recorded an average annual growth rate of 8.4 per cent since 1980 with the fastest growth happening in the last decade. However, while the domestic market is small - some 50,000 Australians take a cruise annually - Australia's cruise potential lies in the growing international recognition as a safe, interesting destination. Measuring the economic impact of a cruise ship's visit is a challenging task. Consideration must be given to whether it is a port of embarkation/disembarkation or a port of call only, and the facilities and infrastructure available for both ship operations and passenger needs. This paper provides estimates of cruise related expenditure using data for Cairns. A framework for classifying cruise related expenditure is developed. This framework can be used to estimate the economic impacts on Cairns of cruise tourism and, depending on data quality, can be used to estimate the net benefits to cairns from this special interest vi sitor market.


The problem we intend to tackle in our study, claims its importance precisely in the thematic antinomy of this approach, conffered by the paradox of analyzing the present through the future. However, we consider that it is much more truthful to carry out an investigation of the present state of humanity from the perspective of its ultimate, meta-historical purpose. The premises from which we start in our research are constituted by certain obvious signals coming from the present state of humanity and which indicate three aspects: 1) reversing the hierarchy of values or the high degree of relativization and contestation of the vertical axis of the apodictic sense and rationality of the world; 2) the predilection of the contemporary man for the immanent and the acute weakening of the taste for the transcendent; 3) the crisis of identity of the person on vertically and on horizontally lines. This project aims to achieve major objectives. One of these is to investigate the extent to which the contemporary world still retains the principle of sense in its evolution, and what is its optics on sense. The conclusion of our research indicates the active manifestation of deist optics on all levels of human life


We present very efficient arithmetic circuits for the computation of the determinants and inverse of band matrices and for interpolation and polynomial arithmetic over arbitrary ground fields. For input size n the circuits for band matrix inversion (for constant band width) over infinite fields, and the circuits for polynomial arithmetic over arbitrary fields, have optimal depth 0(log n) and polynomial size. The algorithm for band matrix inversion is based on an extension of the method of modification (from numerical analysis) which includes a formula for the determinant of a modified matrix.


OBJECTIVE
Two versions of a patient-based DAS (PDAS) 1 and 2 (with and without ESR) have been developed and validated in RA. The objective of this study was to define PDAS1- and PDAS2-based criteria for remission, low, moderate and high disease activity and responses to treatment.

METHOD
Using receiver operating characteristic curves, the optimal thresholds for PDAS1 and PDAS2 that correspond to validated assessor-based DAS (DAS28) and Clinical Disease Activity Index (CDAI) disease statuses were determined. Data from RA patients initiated on disease-modifying drugs were used to determine optimal thresholds for PDAS1 and PDAS2 that corresponded to EULAR good and moderate responses. Agreement with DAS28, CDAI and EULAR response criteria was assessed by Cohen's κ statistic.

RESULTS
Threshold for PDAS1 and PDAS2 demonstrated fair to moderate agreement with DAS28 [κ = 0.44 (95% CI: 0.40, 0.50) and 0.31 (95% CI: 0.25, 0.38)] and CDAI [κ = 0.27 (95% CI: 0.22, 0.33) and 0.42 (95% CI: 0.35, 0.49)] disease statuses, respectively, which was similar to agreement between DAS28 and CDAI [κ = 0.54 (95% CI: 0.46, 0.61)] within this group. Agreement of EULAR good and moderate response with PDAS1 and PDAS2 was κ = 0.46 (95% CI: 0.27, 0.64) and 0.38 (95% CI: 0.20, 0.56), respectively.

CONCLUSION
Thresholds for disease activity statuses and response to treatment for PDAS1 and PDAS2 have been established. They have comparable agreement to assessor-based criteria.


EMF (Electromagnetic Field) is a invisible form of hazard energy which can cause damage to children health such as their brain. This is because the anatomy of children is basically not as tough as adults but it is fragile. Nowadays, many parents in Malaysia doesn't seem to realize or fully aware that cellular phone and tablet can cause brain damage to our children. As a matter a fact, parents use cellular phone or tablet as tools for distracting their children while they are busy with something else. However, there are still a room for doing the right thing which is encourage and always remind the parents of the danger or the hazard of EMF. Cellular phone or tablet radiation that produces by those devices everyday can be harmful to their children. The Intention of this study is to create awareness for the parents to remind that cellular phone and tablet it is not tools that can help them distract their child while they are busy. Questionnaire was used as tools for collecting data from 50 respondents which is by using Typeform.com. In this study, the researcher has used one method and that is quantitative. After finding result, an advertising and a campaign will be creating. The significance is to educate Malaysian parents on the danger of EMF for their children.


geochemical methodology and the third obviously a 'stop press' addition lists additional axes macroscopically identified as Group VI as of March 1997. The 'results' sections clearly but modestly demonstrate the Project's substantial achievements. Six years of intensive work by a core team of just three to four people (including Finola O'Carroll and Emmet Byrnes) has, for example: almost doubled the overall number of known axes in Ireland, from around 10,600 to 20,000, and has revealed a density significantly higher than that of known axes in Britain; demonstrated that the dominance of Co. Antrim porcellanite as a favourite axe material is even greater than previously estimated (at 53.8% of all macroscopically identified specimens, compared with a 1990 estimate of 20-25%); revealed that the number of imported Group VI axes is far higher, and the distribution broader, than previously suspected (with the number of known or suspected examples rising tenfold). Much other useful information is presented, and the monograph and the database will be an extremely valuable research tool for future work. The Project's contribution goes beyond an enhancement of our knowledge base, however. The necessity of developing a systematic computerized recording system from scratch has meant that ISAP has produced a far more sophisticated and standardized database than that achieved by six decades of work by the CBA Implement Petrology Committee and its predecessors in Britain. Furthermore, the Project has avoided the British tendency to study stone axes in isolation from flint axes and, by eschewing the use of Petrological Group Numbers (except for pre-existing ones), it avoids the pitfalls of equating lithological groups with single source areas. All this, of course, is not to decry the considerable achievements of the CBAIPC (now the Trust for Implement Petrology), from whose experience ISAP has benefited and with whom ISAP enjoys a close relationship. It does, however, highlight the advantages of undertaking this kind of research on a large-scale, properly resourced basis. The monograph -and the Project is not without its problems, however. The presentation of results on Group VI axes is split between three parts of the book, and its discussion makes insufficient reference to the results of the Bradley & Edmonds work (1993) on changing production patterns in the Lake District. There are also petrological loose ends to be tied up, as evidenced by the reference to a southeast Irish tuff which can be macroscopically indistinguishable from Group VI tuff, but such problems are acknowledged and are being addressed. There are minor niggles: an index would have been useful, and guardians of terminological exactitude would call 'axes', 'axeheads'. A more fundamental criticism which some might level relates to the Project's rationale. Why invest substantial resources on investigating a single facet of material culture, especially where the chronological resolution may be relatively poor and where findspot information is often imprecise? The team justify the initiative by echoing Ian Kinnes' remarks (directed at Neolithic axes) to the effect that they can he an important indicator of settlement density and broader cultural and economic contacts; they add that, by examining their 'social life' from production to deposition, axes can help to create a narrative on social relationships and beliefs. Their observations throughout the monograph also demonstrate that the drawing of meaningful conclusions requires a sound overview and a solid body of reliable evidence. Monograph 1 is indeed long on description and short on interpretation, but that is a function of the state of the Project. The ISAP team are not unreconstructed 'axe-heads', for whom description is an end in itself. They do ask archaeologically interesting questions of the data they have gathered, and they have provided future researchers with an invaluable tool. ALISON SHERIDAN Department of Archaeology National Museums of Scofland firstname.lastname@example.com


Objective: To analyze the relationship between stress and impulsive behavior in individuals with mental disorders related to substance use and abuse. Method: Cross-sectional analytical study. Assessments were performed using the Childhood Trauma Questionnaire and the Barratt Impulsiveness Scale. Results: Linear regression demonstrated a significant predictability of the total impulsiveness score explained by the total Childhood Trauma Questionnaire, emotional abuse and physical abuse (p<0.05). Motor impulsiveness was significantly predicted by total Childhood Trauma Questionnaire, emotional abuse, physical abuse and sexual abuse (p<0.05). Positive correlations between emotional and physical abuse and the impulsiveness score were identified. In linear regression models, emotional and physical abuse were the main variables influencing impulsiveness. Conclusion: Emotional and physical abuse in drug users influences the manifestations of impulsiveness, so it is pertinent to create strategies aimed at reducing the impacts of impulsiveness and underlying factors.


A PERMANENT HIGHWAY WAS RECENTLY CONSTRUCTED LINKING HUE, THE ANCIENT IMPERIAL CAPITAL OF VIETNAM, AND A COASTAL PORT SEVEN MILES TO THE NORTH EAST. THIS SEABEE PROJECT WAS CONSIDERED NECESSARY AS A SUPPLY LINK TO PERMANENT LST AND LCU FACILITIES. BECAUSE OF CERTAIN GEOGRAPHIC SIMILARITIES THE ROAD WAS DIVIDED INTO THREE PARTS: (1) THE NARROWEST PART THROUGH A ONE-TIME WEALTHY RESIDENTIAL SUBURB OF HUE, (2) A SECTION PARALLELING A LARGE NAVIGABLE CANAL WITH A DENSE GROWTH OF BANANA TREES AND BAMBOO HUTS ON ITS EASTERN SHOULDER, AND (3) AREAS THROUGH THE RICE PADDIES WHICH REQUIRED AS MUCH AS SIX FEET OF FILL IN MANY AREAS. OVER 20,000 CUBIC YARDS OF DREDGE SAND WAS REQUIRED FOR THE ROADWAY EMBANKMENT THROUGH THE RICE PADDIES. A SIX-INCH SAND LIFT WAS RETAINED UNDER THE SOIL CEMENT OF PART II TO PERMIT WATER RISING THROUGH THE LATERITE SUBGRADE TO DRAIN OFF INSTEAD OF BEING CONFINED BY THE OVERLYING SOIL CEMENT, AND TO PERMIT FLOOD WATERS TO EQUALIZE ON EITHER SIDE OF THE ROAD. THE 3.4 MILES OF SAND FILL ROADWAY IN THE RICE PADDIES COULD NOT BE LEFT EXPOSED TO RAIN AND FLOODS DURING THE MONSOONS. THE TOPSOIL OF THE SURROUNDING RICE PADDIES WAS SPREAD ON THE SLOPES BY DOZERS. THIS WAS COMPACTED WITH A GRIDROLLER AND GRADED TO EXTEND THE SLOPE TO 4 TO 1. THIS PROVIDED THE NECESSARY CONFINING PRESSURE TO GIVE THE SAND THE SHEAR STRENGTH REQUIRED FOR DESIGNED LOADS. VARIOUS TYPES OF CEMENT SPREADERS WERE TRIED, BUT NONE WORKED SATISFACTORILY. OVER 100 VIETNAMESE LABORERS WERE CONTRACTED TO PERFORM MANUAL LABOR ON THE ROAD, AND MANY OF THESE ASSISTED IN BAG LAYING AND BREAKING. LACK OF LOCAL ROCK DEPOSITS PRESENTED THE PROBLEM OF OBTAINING 57,000 TONS OF 21/2 INCH BASE ROCK. ROCK WAS BARGED FROM DANANG. PART 1 IS COMPLETELY PAVED, PART II AND III'S SIX-INCH BASE COURSE IS COMPLETED AND ONLY PAVING AND FINISH SLOPE WORK REMAINS.


This research aims to analyze the effect of Managerial Ownership Structure, Operating Cash Flow, and Total Asset Turnover (TATO) on Company Value with Financial Distress as an intervening variable. Case studies in the Coal Mining Sub-Sector listed on the Indonesia Stock Exchange for the 2012-2016 period. The population of this study were 22 Coal Companies, with 20 samples taken based on purposive sampling. Data analysis techniques are Multiple Linear Regression and Path Analysis. The results of the t test showed that the Managerial Ownership Structure and Total Asset Turnover (TATO) did not have a positive and insignificant effect on Financial Distress. Operating Cash Flow has a significant negative effect on Financial Distress. Managerial Ownership Structure does not have a positive and insignificant effect on Company Value. Operating Cash Flows and Financial Distress have no negative and insignificant effects. Total Asset Turnover (TATO) has a positive and significant effect on Company Value. Financial Distress is not able to mediate the Managerial Ownership Structure and Total Asset Turnover (TATO) against Company Value. Financial Distress is able to mediate Operating Cash Flows against Company Value. Based on this research, it is expected that companies can suppress the lowest possible value of financial distress and increase the value of TATO, because TATO is very influential on the value of the company. Keywords: Corporate Value, Managerial Ownership Structure, Operating Cash Flow, Total Asset Turnover (TATO), and Financial Distress.


Monazite grains armored by garnet and quartz retain a concordant 2.48 Ga age that is the same as the age for peak UHT metamorphism in the Napier Complex. Yttrium in the armored grains are unzoned with contents around 700 ppm in the garnet-hosted monazite and range between 400-1600 ppm in the monazite enclosed within quartz. A monazite grain hosted within a mesoperthite grain records a spread of concordant ages from 2.42 to 2.20 Ga and Y contents ranging between 400 to 1700 ppm. This grain exhibits core to rim zoning in both Y and age with the cores enriched in Y relative to the rim and younger ages in the core relative to the rim. A monazite grain that sits on a grain boundary between mesoperthite and garnet records the largest spread in ages– from 2.42 to 2.05 Ga. The youngest ages in this grain are within a linear feature that reaches the core and is connected to the grain boundary between the garnet and mesoperthite, the oldest ages are observed where monazite is in contact with garnet. Yttrium in the grain is enriched in the core and depleted at the rim with the strongest depletions where monazite in adjacent to grain boundaries between the silicate minerals or in contact with garnet.


Introduction: Circulating tumor cells (CTCs) are cells originating from primary and/or metastatic tumor and circulating freely in the peripheral blood of cancer patients. CTCs can serve as a liquid biopsy for real time monitoring of disease progression and therapy efficacy. Due to CTCs rarity in the blood and the lack of strategies to isolate CTCs entire heterogeneous population, CTCs phenotype has not been fully defined. Commonly used epithelial markers-based isolation approaches failed in detecting epithelial mesenchymal (EMT) transitioned CTCs. The purpose of this study was to isolate and characterize the entire population of viable CTCs from metastatic breast cancer (MBC) patients.
Methods: Peripheral blood samples from 44 locally advanced and MBC patients and 4 healthy donors (HD) were collected in this study. In the first part of the study we isolated CTCs from blood samples of 14 MBC patients through an antibody-mediated enrichment procedure (RosetteSepTM). Then, freshly isolated CTCs from 8 samples were analyzed by immunofluorescence (IF), whereas isolated cells from 6 samples were seeded on cover glass. In the second part of the study we isolated circulating cells from 30 MBC samples and 4 HD by using Ficoll density gradient followed by the seeding of free labeled PBMCs on cover glass. In 6/30 samples mRNA expression levels of CD45, ERα, HER2, CK19 and Vimentin were evaluated by qRT-PCR for both PBMCs and adherent cells. Furthermore, IF experiments were performed on adherent isolated cells, and on samples collected after three months of therapy, for testing the presence of ERα, HER2 and different EMT markers.
Results: CTCs isolated by RosetteSepTM protocol stained positive only for the mesenchymal marker Vimentin, and RosetteSepTM seemed to affect the adherence ability of circulating cells. Interestingly, adherent cells isolated by Ficoll stratification showed reduced mRNA levels of leukocyte marker CD45 and higher mRNA levels of CK19 and Vimentin than PBMCs. Also, Vimentin and CK19 proteins were the most representative markers in adherent cells fraction. Furthermore, therapy reduced the number of CD45- cells and affected the number of different adherent cells subpopulations.
Conclusions: We established a label-free method for the isolation and characterization of circulating cells in MBC, which allowed the depletion of most contaminating leukocytes and the enrichment of circulating cells expressing epithelial and mesenchymal markers. Heterogeneity of adherent cells underlined the importance of further characterize these cells to understand more about their role in metastatic disease and to improve personalized therapeutic approaches.


ABSTRACT Background: Several risk factors are able to predict non-alcoholic fatty liver (NAFL) development, but the predictive value of serum alkaline phosphatase (ALP) remains uncertain. Our aim is to investigate the association between serum ALP levels and NAFL. Methods: 21,331 NAFL-free subjects were included. Sex-specific ALP quartiles (Q1 to Q4) were defined. With Q1 used as reference, hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated across each quartile. Results: After adjusting for confounding variables, values in Q2, Q3 and Q4 had HRs (95%CIs) of 1.16 (0.94–1.43), 1.38 (1.13–1.69), 1.51 (1.24–1.83) in females and 0.99 (0.90–1.09), 1.04 (0.95–1.14), 0.96 (0.87–1.05) in males, respectively. A subgroup analysis of age factors in females, from Q2 to Q4, adjusted HRs (95%CIs) were 1.31 (0.81–1.99), 1.86 (1.23–2.81), 2.44 (1.60–3.71) in their 30 s, 1.13 (0.83–1.54), 1.17 (0.85–1.62), 1.65 (1.22–2.25) in their 40 s, and 0.95 (0.51–1.78), 0.91 (0.52–1.62), 0.89 (0.53–1.52) in their 50 s. Conclusions: Higher serum ALP levels are considered a significant predictor for NAFL development in females aged 30 to 50.


Constructivist style that he had worked in alongside avant-garde artists in Germany, in favour of a realist aesthetic based on the quotidian and human figure. However, given Péri's political views and associations, it is clear that his change of style was not merely aesthetic, but was ideological and political.39 Péri himself made this clear in his own writings, describing the shift as a conscious change of direction and specifically referring to it as a 'cleansing process'.40 As early as 1928 in Berlin, Péri had started to experiment with modelling in wet concrete on wire armatures, making small figures in a realist style. By the time he was established as an artist in Hampstead, Péri's work, consisting of coloured wall reliefs and small, free-standing works in concrete – cheap, versatile, industrial – fitted well into the figurative New Realist aesthetic being promoted by leftist artists and critics. Klingender wrote in the communist journal Left Review about his particular brand of realist sculpture, praising its use of concrete and the 'proletarian sensitivity' of works such as Street Corner Meeting of Workers (1933).41 Similarly, for Blunt, Péri's sculpture epitomised a new, socially progressive artform, noting in the catalogue for a solo exhibition of Péri's work in Cambridge: From the crucial Street Corner Meeting of 1933 to the present day, he has devoted himself to the rendering of the ordinary life of people in the streets and parks of London. His groups represent everyday scenes of the workers' life in a straightforward but subtle technique, and in the medium of concrete, the use of which, as the most important building material of today, opens up the possibility that again sculpture may be united with architecture. In this way, sculpture can again become a communal art.42 Through to the mid-1950s and beyond, alongside a leftist perspective, Péri maintained his unfashionable figurative aesthetic, labelled as 'social realist' by Berger at the height of the Cold War.43 That said, it is important to point out that Péri did not share Berger's more discerning leftist views on some of the crucially divisive political issues of the era.44 Berger was a Marxist and had various communist associations, including involvement with the officially designated Communist Party Artists' Group, but he was no apologist for the Soviet regime and indeed was a fierce critic of Stalinist policies.45 In later years, while Péri's politics remained left-wing, his commitment to pacifism drew him to the Quaker community, and he joined the Society of Friends and left the Communist Party.46 As his politics developed a quieter aspect, his work expressed his humanist sympathies more directly, encapsulated most of all perhaps in the Little People series. Péri started to make these during the Second World War when materials for sculpture were scarce, and there were few opportunities to exhibit or sell work. The production of these small figures and groups, some only a few inches high, continued until his death in 1967, by which time his Camden studio was inhabited by hundreds of small concrete figures. Little People depicted men, women and children doing ordinary everyday activities: sweeping the yard, playing games, hanging out washing, changing a lightbulb, waiting for a bus, or reading a newspaper. Individually, these works present closely observed fragments of the quotidian but, in combination, they become a community.47 Even here though, as Henderson explained in 1945, the legacy of his earlier Constructivist approach was evident in the dynamic way he 397 2 7 — G I L L I A N W H I T E L E Y


The purpose of this study was to determine if education through simulation was effective in an undergraduate ADN nursing program to improve nursing confidence, knowledge, skill competency, and nursing care. Two groups of second year RN students were selected in their fall semester to participate in a before and after survey to compare traditional learning (required course readings, assignments, and lectures) with the PROMPT Birthing Simulator that allows hands on, interactive learning, and feedback in preparation for the Mother-Baby clinical setting. The first PDSA cycle with Group A revealed 21% were confident in their knowledge with the traditional learning. Post simulation 47% indicated enhanced confidence and knowledge. The second PDSA cycle was performed on Group B and resulted in 36% feeling confident with traditional learning. Post simulation revealed a 72% increase in confidence and knowledge. Many students verbalized education through simulation was useful and beneficial by enhancing confidence, knowledge, and skill competency. Students report the PROMPT Birthing Simulator better prepared them for the clinical setting by solidifying proper techniques. The PROMPT Birthing Simulator proved to be an effective and useful method, as well as offered students a safe learning environment without the risk of patient harm.


In the human placenta, there are two types of placental macrophages Hofbauer cells of fetal villi and decidual macrophages of maternal decidua basalis. Placental macrophages adopt a specialized phenotype that may hold a key role in synthesis of vital mediators involved in the establishment and maintenance of pregnancy, parturition and maternal-fetal tolerance. Aberrant behavior of these macrophages can affect trophoblast functions and placental development and potentially can lead to a spectrum of adverse pregnancy outcomes. Yet, the populations and functions of placental macrophages in women with different parity and women with preeclampsia remain ill-defined and subject of controversy. Immuno-histochemical study using CD68 primary antibody revealed a significant increase in number of CD68 positive fetal and decidual macrophages in preeclamptic subgroups as compared to controls. Fetal macrophages were seen to be localized near fetal vessel wall and near syncytium which were significantly increased in primiparous preeclamptic subgroup. Our study assumed that there may be intermingling of signals between macrophages and trophoblast cells resulting in impairment of trophoblast invasion and spiral artery remodeling which is the primary placental defect in pregnancies complicated by preeclampsia.In the human placenta, there are two types of placental macrophages Hofbauer cells of fetal villi and decidual macrophages of maternal decidua basalis. Placental macrophages adopt a specialized phenotype that may hold a key role in synthesis of vital mediators involved in the establishment and maintenance of pregnancy, parturition and maternal-fetal tolerance. Aberrant behavior of these macrophages can affect trophoblast functions and placental development and potentially can lead to a spectrum of adverse pregnancy outcomes. Yet, the populations and functions of placental macrophages in women with different parity and women with preeclampsia remain ill-defined and subject of controversy. Immuno-histochemical study using CD68 primary antibody revealed a significant increase in number of CD68 positive fetal and decidual macrophages in preeclamptic subgroups as compared to controls. Fetal macrophages were seen to be localized near fetal vessel wall and near syncytium which were significantly increased in pri...


Online advertisement is an important source of revenue for internet companies, so increasing click-through rates (CTR) on ads is crucial. the traditional CTR prediction model only extracts the classification features and numerical features of the advertisement, but ignores the title, description and other text features of the advertisement. However, we know that such information is very important for an advertisement. Therefore, we propose a deep multimodal network (DMN) to solve this problem. on the basis of the traditional deep model, DMN add the text features of cyclic neural network learning, so as to improve the performance of the model. we also did a lot of visual data analysis on the dataset, Finally, we conducted a comparative experiment on the real-world dataset.


In order to realize the monitoring of human joint rehabilitation, a human motion capture and recognition system is constructed by using micro electro mechanical system (MEMS) sensor nodes. A two-stage extended Kalman filter algorithm is proposed for multi-sensor data fusion. The error matrix between the coordinate system of sensor node and the coordinate system of body was calculated by using the stationary posture calibration. The root mean squared error (RMSE) of the computed joint angle time series is less than 0.5°. The feature of joint angle time series was extracted and the support vector machine (SVM) classification model based on particle swarm optimization (PSO) was established. The experimental results show that the SVM algorithm optimized by PSO has better recognition effect than BP neural network. The average recognition rate can reach more than 97%. The human motion capture system designed in this paper can effectively realize human motion capture, recognition and joint rehabilitation monitoring.


A Ga0.6As0.4P epitaxial wafer, deposited on a GaAs substrate with a compositional graded layer placed between these two substances, was locally heated to temperatures ranging from 600 to 1300 °C (melting point) in air by a Nd:Y3Al5O12 (yttrium aluminum garnet) laser beam. The characteristics of the wafer were determined by three different x‐ray diffraction methods. When the temperature gradient was very steep, large disordering took place in the irradiated region of the wafer. This resulted in the formation of explosive disordered GaAsP, fibrous β‐Ga2O3 on the epitaxial‐layer side, and GaPO4 polycrystals on the graded‐layer side. The characteristic formation mechanisms for these by‐products are discussed.


In the year of 2011,director Liu Cigui of State Oceanic Administration of P.R.C.proposed in the report on the National Oceanic Work with creative ideology that originate from the sea-area and land-area economics and myriads of problems and urgencies of first priority in many rapidly-developed fields of society,make the six respects of regulation,programming,development,resources,environment and disaster-prevention inter-connected in the macroscopic pattern of creativity in land-sea coordination,including economic development,comprehensive management,tap resources and development ideology undergone different dimensions of pondering.Director Liu's report also deeply implies different aspects of idea of Scientific Development:land-sea comprehensive development,coordinated development,balanced development and sustainable development.The report is an outline and sum up for us to know the oceans and make use of the fruits of sea exploration and utilization we have already had.The report is also an essential embodiment and deepening of connotation of the land-sea coordinated development and management of the oceans.


Distributed Bragg reflectors (DBRs) are typically used as the highly reflecting mirrors of vertical-cavity surface-emitting lasers (VCSELs). In order to provide optical field confinement, oxide apertures are often incorporated in the process of the selective wet oxidation of high aluminum-content DBR layers. This technology has some potential drawbacks such as difficulty in controlling the uniformity of the oxide aperture diameters across a large-diameter (≥ 6 inch) production wafers, high DBR series resistance especially for small diameters below about 5 μm despite elaborate grading and doping schemes, free carrier absorption at longer emission wavelengths in the p-doped DBRs, reduced reliability for oxide apertures placed close to the quantum wells, and low thermal conductivity for transporting heat away from the active region. A prospective alternative mirror is a high refractive index contrast grating (HCG) monolithically integrated with the VCSEL cavity. Two HCG mirrors potentially offer a very compact and simplified VCSEL design although the problems of resistance, heat dissipation, and reliability are not completely solved. We present an analysis of a double HCG 980 nm GaAs-based ultra-thin VCSEL. We analyze the optical confinement of such a structure with a total optical thickness is ~1.0λ including the optical cavity and the two opposing and parallel HCG mirrors.


AIMS
This study was undertaken to assess the prevalence of bacterial vaginosis (BV) and to estimate the prevalence of anaerobic organisms in vaginal discharge of women suffering from bacterial vaginosis.

SETTINGS AND DESIGN
Patients attending the Obstetrics and Gynecology Department of a Medical College Hospital. A one year cross-sectional study.

METHODS AND MATERIALS
High vaginal swabs taken from 174 female patients complaining of abnormal vaginal discharge. BV was diagnosed by clinical composite criteria and by gram stain. Anaerobes were isolated and identified from the discharge.

STATISTICAL ANALYSIS USED
Chi square test, with level of significance set at a value of P< 0.05.

RESULTS
BV was diagnosed in 68.39% of the cases by using clinical composite criteria and in 58.4% of the cases by gram stain. Anaerobic culture isolation of vaginal swabs revealed that out of 174 cases 143 (82.65%) were culture positive for anaerobes. Bacteroides were significantly raised in BV as compared with non bacterial vaginosis (NBV; < 0.05%).

CONCLUSIONS
Anaerobic bacteria are important pathogens in the causation of bacterial vaginosis along with other aerobic organisms. Bacteroides and peptostreptococci are significantly raised in BV.


Considering the effect of ground plane, an expression for the far field radiation pattern has been derived. Due to the ground plane an image of the helix is formed. The helix and its image thus form an array of two identical sources in phase opposition. Theoretical pattern on this basis are compared with the existing measured patterns. It is concluded that there is a reasonably good agreement between the theoretical and experimental results. The effect of varying the phase centre with frequency has also been investigated.


The bow-tie antenna is one of common antennas used in Ground Penetrating Radar (GPR) system, due to its manufacturing facilely. GPR system is an effective tool for nondestructively sensing subsurface environment. Various GPR systems are used to detect objects such as pipes, cables, mines and UXO (unexploded ordnance) buried under the surface of the earth. The main problem for GPR antenna, addressed here, is the impedance mismatch. Antenna matching problem which is the input impedance variation with respect to different antenna elevations and ground type, makes it difficult to match antenna to feed line. Here a new method for a better dynamic performance of GPR is proposed. Optimization tool used here is neural network.