Patients with PsA and axial involvement have higher disease activity and greater reductions in quality of life; however, there are no accepted criteria for identifying axial involvement in PsA. The objective of this post-hoc analysis is to assess the efficacy of upadacitinib (UPA), a Janus kinase inhibitor, on axial symptoms in patients with active PsA and axial involvement defined by investigator assessment and PRO-based criteria from two phase 3 SELECT trials.

 Patients with active PsA (≥3 swollen joints and ≥3 tender joints) and prior inadequate response or intolerance to ≥ 1 non-biologic (SELECT-PsA 1) or ≥ 1 biologic (SELECT-PsA 2) DMARD were randomly assigned to once daily oral UPA 15 mg or 30 mg, placebo (PBO), or every other week subcutaneous adalimumab (ADA) 40 mg (SELECT-PsA 1 only). At baseline, axial involvement in PsA was determined by investigator assessment based on the totality of clinical information, such as duration and character of back pain, age of onset, and previous imaging. In addition to investigator assessment, PRO-based criteria for axial involvement (BASDAI ≥4 and BASDAI Question 2 ≥4 at baseline) were applied for this analysis to identify patients with active disease. Efficacy in the sub-group of patients defined using both investigator assessment and PRO-based criteria was evaluated at week 24 for UPA 15 mg vs PBO and ADA (SELECT-PsA 1 only). Data were analyzed using mixed-effect model repeated measures (MMRM) or non-responder imputation (NRI), with nominal P-values shown.

 Based on investigator assessment alone, 31.3% (n = 534/1704) of patients in SELECT-PsA 1 and 34.2% (n = 219/641) in SELECT-PsA 2 were defined as having axial involvement. When both investigator assessment and PRO-based criteria were applied, 23.1% (n = 393/1704) of patients in SELECT-PsA 1, or 73.6% (n = 393/534) of those defined using investigator assessment alone, and 27.5% (n = 176/641) in SELECT-PsA 2, or 80.4% (n = 176/219) using investigator assessment alone, met the combined criteria for axial involvement. In both studies, UPA 15 mg showed significantly greater clinical responses vs PBO at week 24 across all endpoints assessed. In SELECT-PsA 1, UPA showed numerically greater responses than ADA at week 24 across all BASDAI and Ankylosing Spondylitis Disease Activity Score (ASDAS) endpoints. The proportion of patients achieving ASDAS clinically important improvement (CII) at week 24 was significantly greater with UPA vs ADA based on nominal P-value.

 Patients with active PsA and axial involvement defined by both investigator assessment and PRO-based criteria demonstrated statistically greater clinical responses related to their axial involvement with UPA 15 mg compared to PBO, and consistently numerically higher responses compared to ADA, at week 24 in the SELECT-PsA trials. Findings from this post-hoc analysis are consistent with previous data based on investigator assessment alone.
 Disclosure
 X. Baraliakos: Consultancies; X.B has acted as a consultant for AbbVie, Bristol-Myers Squibb, Celgene, Chugai, Eli Lilly, Galapagos, Gilead, MSD, Novartis, Pfizer, and UCB. Member of speakers' bureau; X.B is a member of speaker bureau for AbbVie, Bristol-Myers Squibb, Celgene, Chugai, Eli Lilly, Galapagos, Gilead, MSD, Novartis, Pfizer, and UCB. Grants/research support; X.B has received grant/research AbbVie, Bristol-Myers Squibb, Celgene, Chugai, Eli Lilly, Galapagos, Gilead, MSD, Novartis, Pfizer, and UCB. R. Ranza: Consultancies; R.R has Acted as a consultant for AbbVie, Janssen, Novartis, and Pfizer. Member of speakers' bureau; R.R is a member of speaker bureaus for AbbVie, Janssen, Novartis, and Pfizer. A. Ostor: Consultancies; A.O has acted as a consultant for AbbVie, Bristol-Myers Squibb, Eli Lilly, Gilead, MSD, Novartis, Pfizer, and Roche. Member of speakers' bureau; A.O is a member of speaker bureaus for AbbVie, Bristol-Myers Squibb, Eli Lilly, Gilead, MSD, Novartis, Pfizer, and Roche. F. Ciccia: Consultancies; F.C. has acted as a consultant for AbbVie, Bristol-Myers Squibb, Celgene, MSD, Novartis, Pfizer, Janssen, Sanofi, Sandoz, Galapagos, Sobi, and UCB. Member of speakers' bureau; F.C is a member of speaker bureaus for AbbVie, Bristol-Myers Squibb, Celgene, Novartis, Pfizer, and UCB. Grants/research support; F.C has received grant/research support from AbbVie, Celgene, Pfizer, Roche, and UCB. L.C. Coates: Honoraria; L.C has has received honoraria from AbbVie, Amgen, Biogen, Boehringer Ingelheim, Celgene, Galapagos, Gilead, GSK, Janssen, Eli Lilly, Medac, Novartis, Pfizer, and UCB. Grants/research support; L.C has received grant/research support from AbbVie, Amgen, Celgene, Eli Lilly, Novartis and Pfizer. S. Rednic: Consultancies; S.R is a consultant for AbbVie, Boehringer Ingelheim, Eli Lilly, MSD, Novartis, and Pfizer. Grants/research support; S.R has received grant/research support from AbbVie, Boehringer Ingelheim, Eli Lilly, MSD, Novartis, Pfizer, and UCB. J. Walsh: Consultancies; J.W has received consultancy fees from AbbVie, Amgen, Eli Lilly, Merck, Novartis, Pfizer, and UCB. Grants/research support; J.W has Grants from AbbVie, Amgen, Eli Lilly, Merck, Novartis, Pfizer, and UCB. T. Gao: Shareholder/stock ownership; T.O is an employee of AbbVie and may hold options and stocks. A. Lertratanakul: Shareholder/stock ownership; A.P is an employee of AbbVie and may hold options and stocks. I. Song: Shareholder/stock ownership; I.S is an employee of AbbVie and may hold options and stocks. F. Fabiana Ganz: Shareholder/stock ownership; F.G is an employee of AbbVie and may hold options and stocks. K. Douglas: Shareholder/stock ownership; K.D is an employee of AbbVie and may hold options and stocks. A. Deodhar: Consultancies; A.D has received consultation fees from AbbVie, Amgen, Aurinia, BMS, GSK, Janssen, Lilly, MoonLake, Novartis, Pfizer and UCB. Honoraria; A.D has received honoraria's from AbbVie, Amgen, Aurinia, BMS, GSK, Janssen, Lilly, MoonLake, Novartis, Pfizer and UCB. Grants/research support; A.D has received grant/research support from AbbVie, GSK, Lilly, Novartis, Pfizer and UCB.


Definition of privacy has changed by the changes and improvements in information and surveillance technologies. These changes and improvement need new legal decisions for new kinds of privacy invasions. This study explores the scope of privacy right, particularly when a technological surveillance has occurred by law enforcement agencies. It focuses in particular on increasing law enforcements' surveillance technologies and devices that have the potential to impact citizens' information privacy. These increasing changes in surveillance technologies have important implications both for law enforcements and citizens. This study also discusses increasing law enforcement surveillance for the public's security, changes of the laws that allow law enforcements to use new surveillance powers as a war on terrorism, and the citizens concerns of information privacy. A particular attention is given to the recent public opinion surveys which show citizens' increasing privacy concerns. Finally, a set of recommendations to figure out security-privacy debate and reduce the privacy concerns of the citizens is offered.


'Milo', a monoecious slicing cucumber (Cucumis sativus L.) F1 hybrid (Fig. 1), was released by the College of Tropical Agriculture and Human Resources (CTAHR). It was developed for the local market preference for crisp ovary wall. 'Milo' is resistant to cucumber mosaic virus (CMV) and watermelon mosaic virus 2 (WMV-2) and tolerant to powdery mildew [Sphaerotheca fuliginea (Schlecht. ex Fr) Poll.].


Multiple prioritised access category (AC) queues and virtual collision handling among them are the main mechanism of the IEEE 802.11e EDCA for multimedia service differentiation. However, the AC for video (AC_VI) is characteristic of FIFO, and thus its performance is limited. For further performance enhancement, differentiation among video packets can help. This study presents a novel cross-layer design combining the error propagation length (EPL) scheme in the application layer allowing each video frame in a group of pictures to have its own importance level, and our proposed split piecewise mapping (SPM) algorithm in the MAC layer offering a corresponding mapping probability function for each importance level of video packets among the AC queues. The results show that the proposed EPL+SPM design outperforms the existing ones, with largest achieved gains as high as 2.8 dB over I/P+PM, 4.1 dB over I/P+AM and 7.4 dB over EDCA.


The invention relates to a cotton cultivation method, which plants cotton in soil or light soil, and comprises: (1) preparation before sowing, which comprises land preparation and full-layer fertilizer application, wherein land preparation is to make the land flat, fine and free from weeds by rebuilding head and sides of a land which unfreezes in early spring, performing chemical weeding on the land by using a herbicide, and harrowing in time, and the full-layer fertilizer application is to apply urea and diammonium phosphate before turning up the soil; (2) sowing, namely sowing when the temperature of the soil 5 centimeters under a film is constantly above 12 DEG C and planting a maize trapping and killing zones after the cotton seed are sown, wherein mechanical hole sowing is adopted, 3 to 4 seeds are sown in on hole, and the sowing depth is 1.5 to 2 centimeters; and (3) field management which comprises breaking hardened soil, intertillage, final singling, chemical control, dripping water, topdressing, removing tip, and preventing and controlling pests. When the method of the invention is used, the lint cotton yield per mu is over 200 kilograms.


Various iterative algorithms for interference avoidance (IA) in networks with co-located receivers, suitable for distributed implementation, have been proposed in the literature. In this paper, the IA problem is cast in a game-theoretic framework and is formulated as a potential game. This formulation accommodates previously proposed algorithms and, in addition, gives us a framework that enables the design of new distributed and convergent algorithms for IA including algorithms with nonidentical utility functions for the users. Two new convergence results for potential games are then derived. The first result establishes the convergence of a class of potential games to the global solution while following best response iterations and when noise is added. The second result establishes the convergence of potential games to the Nash equilibria of the game while following random better response iterations. The first result combined with the potential game formulation allows us to show that for a large class of network scenarios, arbitrarily small noise assures the convergence of best response IA algorithms, including the eigeniterations, to an arbitrarily small neighborhood of the globally optimal signature sequence set. The second result enables the design of reduced feedback mechanisms for IA that converge to desirable solutions.


This thesis is about the improvement of software tools and methods for analyzing high resolution γ-ray spectroscopy data of intermediate energy Coulomb excitation experiments at the PreSPEC-AGATA setup. In the past, pioneering experiments have been done in the RISING campaign at GSI. The PreSPEC-AGATA setup has been the next step in the evolution of this type of experiments, with better and more complex instrumentation, leading to higher sensitivity and resolution. This work is relevant for for the preparation of the even more demanding future HISPEC setup at the upcoming FAIR facility. HISPEC experiments will study low-lying excited states of nuclei far from stability, in order to test the validity of nuclear structure models in that area of the nuclear chart.
More complex instrumentation results in more complex data analysis programs. In order to deal with the complexity involved in developing such software for the upcoming experiments, a more systematic approach to the development process is needed. Within this work, a software framework was developed to facilitate a systematic and clean software design. This might be helpful for upcoming NUSTAR experiments at FAIR, where a large number of independent detector systems have to be integrated into a big setup. The design of the framework is discussed in the second chapter of this thesis.
One important reaction mechanism for the HISPEC experiments is Coulomb excitation at energies of around 150 MeV/u. Because of the purely electromagnetic nature of the interaction, Coulomb excitation is described well by theoretical models. In the third chapter of this thesis, a numerical simulation program for relativistic ion-ion collisions was developed that solves the coupled channel equations for electric Coulomb excitation.
In the fourth chapter, the relevant detector systems of the PreSPEC setup are presented, and the calibration of them is discussed. A main aspect of the work was the development of improved ways to analyze data from these devices, and, if possible to provide semi-automatic implementations for their calibration.
In the last chapter, the total efficiency of the PreSPEC-setup was determined for a typical Coulomb excitation experiment, and the possibility to measure projectile excitation cross-sections relative to a target excitation cross-section is demonstrated.


One of the goals of dentistry is to develop new approaches in restorative dentistry that will reduce the amount of tooth removal during treatment. With advances in material science and restorative techniques, we are able to attain these ideals and recreate nature with minimal removal of tooth structure. The latest developments in minimally invasive dentistry (MID) and its impact on esthetic restorative dentistry will be discussed (Fig. 1 and 2).


The present invention relates to relates to a novel pyrazolopyrimidine compound, a method for their preparation and pharmaceutical compositions containing them represented by the following formula (1), the compounds of the present invention can be effectively used in one of the erectile dysfunction treatment of sexual dysfunction in men have. (In the general formula 1 R 1, R 2, R 3 and R 4 are as described in the specification.)


The emergency management strategies to hostages,their processes and outcomes,are not only closely connected with the security and interests of the hostages,but they also directly affect the Government's anti-terrorism policies and positions,the capacity and governance quality,and the governmental status and image in the eyes of the public.The disposal of terrorist hostage incident puts the great pressure and challenges on commanders.Can the use of force and when to resort to force is the key commanders operational decision-making based on the principle of a contrast analysis and quantitative assessment to find the best solution.


Abstract The design of a spar buoy, employed as one component of a current monitoring system deployed during 1980 in Davis Strait, and some of its response characteristics to ocean waves are presented. The buoy was 36.5 ft (11.13 m) in length with upper and lower masts 0.5ft (15.2 cm) in diameter and buoyancy hulls, centrally located, 2 ft (61.0 cm) in diameter. Power for the system was supplied from lead‐acid batteries in a ballast tank on the lower end. Telemetry electronics were located in a 1‐ft (30.5‐cm) diameter case on the upper end, below the antenna. The buoy weighed about 1,635 lb (746kg) and could be man‐handled at sea with relatively light lifting equipment. It had a damped period of 16s and a significant heave response of about 62% of the significant wave height of the forcing spectrum. Scale model tests indicated that the buoy would be operational in heavy sea swell up to about 20ft in height with pitching angles of less than 10° off vertical. Observations at sea have shown that the buoy fol...


Since the beginning of 2020, the worldwide COVID-19 pandemic made it necessary to change our lifestyles (e.g., restrictions on transport or travelling and forced telework). This has also changed the environmental impact of our lifestyles. To quantify that impact, we used surveys to calculate the Ecological Footprint (EF) and environmental concern of Belgian respondents in 2021 and compared this to the EF-situation in 2017, before COVID-19. We observed that the EF became significantly lower during the COVID-19 crisis. Of course, this change in behaviour is the result of compulsory measures. Therefore, we asked about people's willingness to reduce the EF permanently, particularly after COVID-19 and on a voluntary basis. We observed that, in 2021, respondents had a strong desire to return to a pre-COVID-19 lifestyle and that they are even less concerned about the environment than they were in the period before COVID-19. Moreover, these results hold after taking into account the effect of different explanatory variables in a multivariate analysis. As a general conclusion, there is little or no evidence that COVID-19 will fundamentally change the environmental impact of our behaviour or our environmental concern if there is no associated public intervention. There is a need for policies that make use of the potential created by COVID-19 (e.g., stimulate working from home and increased cycling).


The implementation of extended reach horizontal wells in Saudi Arabia, in the southern area of the Ghawar field in particular, is being increased for production and cost optimization. Logging these wells is a challenge, as the production profile of a horizontal section cannot be entirely recorded with conventional coiled tubing (CT). This is mainly because of friction forces between the CT and the wellbore, which cause the CT to lockup significantly shallower than the total depth (TD). Even with the availability of a limited technique, such as a metal to metal friction reducer, it was found that the CT reach cannot be maximized effectively. This article will describe successful utilization of an agitator tool with a custom designed e-line bypass that helps the CT maximize the coverage of the horizontal section for logging purposes. The agitator tool was incorporated into the Production Logging Tool (PLT) and bottom-hole assembly (BHA). It was activated by pumping. It caused the CT string to vibrate and subsequently reduce the friction contact between the CT and the wellbore to allow the CT to run beyond the normal lockup depth. The tool was trial tested in an extended reach horizontal well, with a TD of 12,118 ft. The simulator showed a predicted lock at 10,400 ft while a dummy run locked up at 10,800 ft without activating the agitator. The e-line agitator was activated while the well was flowing at a restricted rate, which maximized the reach to the TD and reduced the friction coefficient by around 26%. Different conditions and parameters were applied to understand the best performance of the e-line agitator tool. The implementation of the e-line agitator resulted in extending the reach of the CT by an additional 1,300 ft and reaching TD. This additional reach was significant, as the last part of the horizontal section was contributing water. The production log has been reviewed and shows acceptable measurements. This article will cover the whole cycle of candidate selection, job design, execution, post job evaluation, lessons learned and conclusion.


We present twelve new simulations of unequal mass neutron star mergers. The simulations were preformed with the SpEC code, and utilize nuclear-theory based equations of state and a two-moment gray neutrino transport scheme with an improved energy estimate based on evolving the number density. We model the neutron stars with the SFHo, LS220 and DD2 equations of state (EOS) and we study the neutrino and matter emission of all twelve models to search for robust trends between binary parameters and emission characteristics. We find that the total mass of the dynamical ejecta exceeds $0.01M_\odot$ only for SFHo with weak dependence on the mass-ratio across all models. We find that the ejecta have a broad electron fraction ($Y_e$) distribution ($\approx 0.06-0.48$), with mean $0.2$. $Y_e$ increases with neutrino irradiation over time, but decreases with increasing binary asymmetry. We also find that the models have ejecta with a broad asymptotic velocity distribution ($\approx 0.05-0.7c$). The average velocity lies in the range $0.2c - 0.3c$ and decreases with binary asymmetry. Furthermore, we find that disk mass increases with binary asymmetry and stiffness of the EOS. The $Y_e$ of the disk increases with softness of the EOS. The strongest neutrino emission occurs for the models with soft EOS. For (anti) electron neutrinos we find no significant dependence of the magnitude or angular distribution or neutrino luminosity with mass-ratio. The heavier neutrino species have a luminosity dependence on mass-ratio but an angular distribution which does not change with mass-ratio.


Based on the 4×4 matrix method,we present theoretical calculations of the magneto-optic polar Kerr effect with the incident energy in granular films.It is found that the simulated results are in good agreement with experimental ones.In addition,Kerr rotation and ellipticity as functions of incident angle and magnetic film thickness have been computed.The calculated results indicate that the Kerr spectra as a function of the incident angle reveal a maximum at certain incident angles and the Kerr spectra appear to be periodical and have damped oscillation as a function of the magnetic film thickness,which is important for the design of the materials in the future.


Data warehouses and OLAP (Online Analytical Processing) provide tools to explore and navigate through data cubes in order to extract interesting information under different perspectives and levels of granularity. Nevertheless, OLAP techniques do not allow the identification of relationships, groupings or exceptions that could hold in a data cube. To that end, we propose to enrich OLAP techniques with data mining facilities to benefit from the capabilities they offer. In this paper, we propose an on-line environment for mining association rules in data cubes. Our environment, called OLEMAR (On-Line for Mining Association Rules), is designed to extract associations from multidimensional data. It allows the extraction of inter-dimensional association rules from data cubes according to a sum-based aggregate measure , a more general indicator than aggregate values provided by the traditional COUNT measure. In our approach, OLAP users are able to drive a mining process guided by a meta-rule which meets their analysis objectives. In environment is based on a formalization which exploits aggregate measures to revisit the definition of the support and the confidence of discovered rules. This also helps evaluate the interestingness of association rules according to two additional quality measures: Lift and . effectiveness and the efficiency of our proposal, we analyze a real-life case study about breast cancer data and conduct performance experimentation of the mining process.


This study is focused on analyzing characterization in "Five Feet Apart "movie by Justin Baldoni. This study has two aims, namely 1) to find out the types of characterization and to describe the main character in "Five Feet Apart" and 2) to find out the characterization of the main character realized in "Five Feet Apart" movie by Justin Baldoni. The data were analyzed based on the theory proposed by Kenney (1996) and Wellek and Warren (1962). The result of this analysis showed that there were 5 types of characterization from Kenney theory such as Discursive Method, Dramatic Method, Character on other Character, Mixing Method and Contextual Method and 3 theory dimension characterization such as Physiological Dimension, Sociological Dimension and Psychological Dimension.


This thesis introduces the control principle of the constant temperature control system based on STC89C52RD+ Single-chip Computer in detail. Meanwhile, the thesis also displays the application of the control principle involving the design of hardware and software and the security during the constant temperature control process.


Male and female adult Adoxophyes orana F.v.R. were irradiated within 24 h of eclosion with doses of X‐rays between 2.5 and 22.5 krad and with 3 krad fast neutrons. The treated moths were single pair mated with untreated moths and egg hatchability was assessed. The surviving F1 progeny and also succeeding generations were tested in a similar manner. Mortality of larval and pupal stages and sex ratios were also determined. Differences observed between the fertility of the F1 from irradiated males and from irradiated females led to the hypothesis that the time of meiosis with respect to the time of irradiation is of crucial importance in the expression and inheritance of the induced rearrangements. Consequences for differences in radiosensitivity between sexes and for the application of sub‐sterile insects for practical control purposes are discussed.


Introduction: Arsia mons (Figure 1: A, C and F), Pavonis mons (Figure 1: A, D and G) and Ascraeus mons (Figure 1: A, E and H) are large shield volcanos located in Tharsis Volcanic Provinces (Figure 1: A and B) of planet Mars. In the present study, reflectance data of MRO-CRISM (Figure 1: F, G and H) was used to map silicate mineral pyroxene in Arsia chasmata, a steep sided depression located in the northeastern flank of Arsia mons and in caldera region of Pavonis and Ascraeus mons. The presence of these minerals provides the evidence for origin and formation of the Tharsis provinces. Absorption features obtained from the analysis are at 1.24 μm, 1.45 μm, 1.65 μm and 2.39 μm in Arsia chasmata region, 1.24 μm, 1.50 μm, 1.70 μm and 2.40 μm in the caldera region of Pavonis mons and 1.24 μm, 1.50 μm, 1.65 μm and 2.30 μm in the caldera region of Ascraeus mons suggesting highly altered pyroxenes. Pyroxene minerals outcrops found in early-Noachian to mid-Noachian period must be exposed by erosion from mantle [1]. The ancient Noachian aged units suggests that the deposits were derived from a mantle depleted in aluminum and calcium [1]. Very feeble mineralogical analysis are available in the literature for all mons and therefore the present research contribute to understand process of formation and origin of Tharsis province and associated mineralogy.


Military personnel are at particularly high risk of PTSD because deployments to combat zones increase the risk of exposure to trauma. The effects of PTSD on military and civilian patients, their families, and society in general can be profound. Posttraumatic stress disorder is associated with increased risks of sui


Abstract Setting out from the Simmelian premise that fashion is the site of tension between conformity and distinction, this essay enquires into the element of distinction heightened in minimalist luxury fashion. Minimalist luxury reveals the inherently divisive nature of fashion, putting distance between "us"—the nonchalant, productive, and moral—and "them"—the vulgar, useless, and amoral. Its seeming austerity is an effective mechanism of status assertion, highlighting fashion as a continual cycle of exclusion. The essay examines the class-, gender-, and race-bias implicated in minimalist luxury, before using Martin Margiela's contrasting practice at Maison Martin Margiela and at Hermès as one case in which the ideals of minimalist luxury are strategically exploited. The case of Margiela also underscores the challenge luxury fashion faces as digital mediation increasingly prioritizes fashion as a visual, rather than material, practice. Digital mediation facilitates the global diffusion of the minimalist aesthetic, dividing the world into mythical classes according to taste, which supports Simmel's idea of fashion and its potential pertinence to wider intercultural relations.


Ever since the pioneering work of Elliott (Elliott J P 1958 London Series A 245 128, 562), quadrupole collectivity in deformed nuclei has been economically described in terms of symmetry. Microscopic symmetry is not present in the deformed intrinsic states of n nucleons in the abnormal-parity single-particle states . However, such states do possess some -symmetry-like properties as shown in this work.


In "A Mythological Parallel to a Visual Obsession" (1916), Freud presents the case of a patient, a young man about twenty-one years old, whose "unconscious mental activity became conscious not only in obsessive thoughts but also in obsessive images" (338). In the very brief history–only one-and-a-half pages–he compares the man's symptoms with an archeological oddity of which he had recently learned. Yet, the reader can't help but notice that something is unclear right from the start, something is covered up. Despite the plural of the obsession


The Xiangfan—Guangji fault(XGF) which separates the Dabie orogen belt(DOB) from the Yangtze block is the south boundary fault of the DOB.The XGF is divided into two parts by the Jianghan rift basin.The western and eastern parts of the XGF show significantly different structural features.The western XGF is characterized by typical N-dipping listric margin fault that has a thrust displacement of at least 30km,while the eastern part underwent more complex tectonic evolution.After a similar initial southward thrusting with the western part,the eastern DOB made a large-scale southwestward thrust onto the North Yangtze foreland basin along the XGF in late Jurassic.The low angular N-dipping XGF was then rebuilt by succedent northward compression from the Jiangnan uplift while the deep still shown southward thrusting features.New field structural data,40Ar/39Ar ages,zircon LA-ICP-MS ages and sedimentology evidence indicate that the XGF have experienced twice significant southward thrusting since Middle Triassic: 40Ar/39Ar ages indicate that both the XGF and the Huwan detachment,south and north margins of the DOB respectively,were formed contemporaneously as a result of the initial extrusion of UHP from mantle to lower crustal level during the continental—continental collision stage in Early Triassic(about 240~231Ma);the second apparent thrusting was in Middle—Late Jurassic(about 160~140Ma) before the DOB's thermal doming extension for the granitic intrusion during this period wasn't involved into deformation.The first thrusting was characterized by inner orogen ductile,Brittle—ductile deformation accompany with exhumation of UHP terrains while the second was characterized by large-scale(thrusting distance60km) low-angle shallow thrusting of the south margin of the DOB against above the North Yangtze foreland.During this period,extension of the north margin,large-scale thrusting of the south margin together with the contemporary sinistral strike-slip of the east margin of the DOB draw a clear tectonic framework and indicate a clockwise rotation of the eastern DOB.


A practical route is described for the preparation of myo-inositol phosphates. Optically pure compounds can be prepared, in both forms, from p-benzoquinone by enzymatic resolution of a diacetoxyconduritol key intermediate. Monosubstituted inositol derivatives can be obtained by breaking the C2 symmetry of conduritol B derivatives. A wide variety of myo-inositol phosphates can be synthesized by combining the previously reported symmetrical approach with this new nonsymmetrical approach. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005)


Talk affirmation is one among the basic zones in cutting edge talk process. The examination of talk affirmation may be a bit of an examination for "artificial intelligence" machines that may "hear" and "appreciate" the verbally communicated data. The customary ways for talk affirmation like HMM and DTW, are outrageously inconvenient and time excellent. As such formal Fuzzy justification may be an endeavor in cutting edge talk process for the convincing portrayal of talk affirmation in a couple of utilization. The approach masterminded in the midst of this paper streamlines the utilization of fuzzy in talk affirmation and make the data dealing with time shorter. The case considered in the midst of this paper is that the least mind boggling, i.e., the example of speaker dependence, little vocabulary and disconnected words. There are various spectral and common choices isolated from human talk. The present ways for tendency acknowledgment from voice use basically MFCC and Energy feature. This paper briefs an overview concerning the present work on talk feeling ID strong for completing more examination by feathery approach.


ABSTRACT  The U.S. Coast Guard has been developing a 47′ high-speed, heavy weather motor lifeboat, the 47 MLB, to replace the aging 44′ motor lifeboats. The 47 MLB is designed to be self-righting and operate in up to 20′ breaking waves. The prototype 47 MLB has been in service for four years, and five pre-production boats have been built by Textron Marine Systems in New Orleans, La. If the pre-production boats prove to be successful, plans call for 100 boats to be built in the production run.

One of the primary goals in developing a new motor lifeboat was to make major improvements with regard to crew safety, comfort, and efficiency. These human engineering requirements have affected almost every stage of the design, and have been the subject of considerable engineering effort. Throughout the development, a logical human engineering program has been followed. This program will continue through the pre-production evaluation and into the production craft development.


Additive manufacturing (AM) is an interesting technology with the potential to replace general fabrication techniques such as machining, forming and casting. AM provides two main benefits: greater freedom of part design and lower material consumption. To improve quality, many researchers have investigated the mechanical characteristics of AM products and additive parameters. In the present study, tensile and fatigue tests were conducted on stainless steel (SS) 316L manufactured using powder bed fusion (PBF) technology. These tests were carried out using two different building directions, along the Z and X axis, to investigate the effect of additive direction. In addition, the effects of hot isostatic pressing (HIP) related to fatigue properties, which can influence the volume density and porosity of the specimen, was studied. Based on the test results, changes in the mechanical characteristic and fatigue strength due to the HIP treatment were investigated.


Objective\ To evaluate the efficacy and safety of laser in situ keratomileusis(LASIK) for the correction of high myopia.\ Methods\ 90 eyes of 46 high myopia patients were divided into two groups:Ⅰ -6 25~-10 0 D, 63 eyes; Ⅱ≥-10 25 D, 27 eyes.\ Postoperative results with a follow up of at least one year were analyed.\ Results\ At postoperative 12 months the rates of uncorrected visual acuity equal or better than the best preoperative corrected visual acuity were 93 7% in group Ⅰ, and 88 9% in group Ⅱ.\ Corrected rate of ±1 0 D were 95 2% in group Ⅰ and 88 9% in group Ⅱ.\ No severe complications were observed in and after LASIK.\ Conclusion\ LASIK is an effective method to correct high myopia.\;


The present invention relates to a no wrinkles occur the polyvinylidene fluoride resin is excellent in view of liquid electrolyte in the separator is also used as a separator material, to lower the internal resistance is excellent in high temperature storage characteristics and the overcharge characteristic non-aqueous electrolyte secondary battery. The non-aqueous electrolyte secondary battery is a separator (10) to, a polyvinylidene fluoride resin (12) to charge by integrating a composite resin film, or the separator 20 to the reinforcing material 11 can fluoride polyvinylidene fluoride resin of the present invention ( 21) and to form a composite resin film by laminating a reinforcing layer (22). In this way, integrated by charging the polyvinylidene fluoride resin 12 to the reinforcement layer 11 or, when stacking a polyvinylidene fluoride resin layer 21 to the reinforcement layer 22 is polyvinylidene fluoride resin may be swollen his swelling of the width direction and the longitudinal direction is not wrinkled when the separator 10, 20 is caused because the limit to the reinforcing material 11, 22. Polyvinylidene fluoride resin, a non-aqueous electrolyte secondary battery.


On-line supervised learning in the general K Tree Committee Machine (TCM) is studied for a uniform distribution of inputs. Examples are corrupted by noise in the teacher output. From the diierential equations which describe the learning dynamics, the algorithm which optimizes the generalization ability is exactly obtained. For a large number of presented examples, the asymptotical behaviour of the generalization error is shown to be independent of K, for nite K.


Manufacturing taxonomies and accompanying metadata of manufacturing processes have been catalogued in both reference books and databases on-line. However, such information remains in a form that is uninformative to the various stages of the product life cycle, including the design phase and manufacturingrelated activities. This challenge lies in the varying nature in how the data is captured and represented. In this paper, we explore measures for comparing manufacturing data with the goal of developing a capability-based similarity metric for manufacturing processes. To judge the effectiveness of these metrics, we apply permutations of them to 26 manufacturing process models, such as blow molding, die casting, and milling, that were created based on the ASTM E3012-16 standard. Furthermore, we provide directions towards the development of an aggregate similarity metric considering multiple capability features. In the future, this work will contribute to a broad vision of a manufacturing process model repository by helping ease decision-making for engineering design and planning.


Abstract The aim of this work is to provide a cogent review of biomarketing. This review work will pave the way for the study of how brand engagement and buying decision could be understood through the biological perspective by holistic and strategic marketing communications. The methods used was the mining of relevant literature and websites on marketing with perspective of biology. Biomarketing is an emerging discipline that traverse the fields of social and biological science. Biomarketing pose that the interactions between salespeople and customers can be studied from a biological perspective. The emerging research in marketing studies of buyer–seller interactions has explored the role of genes, hormones, and pleasure and pain processes. Clarity in health communication aid customer understanding of brand information. Future work in biomarketing field would be to investigate the mechanistic association of biomarkers in brain and blood of customers with the brand and the market benefits.


[Objective]The research aimed to provide the theoretical basis for the selection of the new rice varieties with high nitrogen use efficiency.[Method] Six rice samples of different rice genotypes were induced with different concentration nitrogen in different growth periods.And the glutamine synthetase activity in rice vegetative period was determined.[Result] Under the induction of different concentration nitrogen,the glutamine synthetase activity of the female with high nitrogen use efficiency was higher than that of paternal with low nitrogen use efficiency.And the glutamine synthetase activity of hybrid generation was higher that of the parents.[Conclusion] The glutamine synthetase activity could be taken as physiological predictor for the selection of the new rice varieties with high nitrogen use efficiency.


Razors. Ball point pens. Diapers. Towels. Paper plates. Plastic forks. TV dinner trays. Fast food boxes. Pop bottles. Our world is full of disposable personal objects, transient things soon discarded. Ten years ago began the debates about s t ructured programming, which sought more correct, more understandable software through restricted program forms. These debates helped bring forth programming languages with strict syntactic structure--e.g., Pascal, Fortran 77, and lately Ada. They stimulated new texts on programming and new sets of rules for students in programming courses. But our students go on to be professional programmers whose software is unreliable and unportable; who often construct new programs from scratch rather than from existing programs; who keep such poor records that they cannot later reuse their programs. We continue to rely heavily on a small set of highly gifted software architects to keep our computer systems running. Why is this? Why is so much software of poor quality? Not distributable? Why so little progress toward transportable software parts despite so much attention to program structure and project management? The


Acting learning makes students study actively and positively,which improves students to develop their lifelong learning ability.The aim of language teaching is not only to make students grasp the language itself,but also to enhance their ability of active learning.In college English teaching,teachers should realize the transform from teachers-centered educational model to students-centered educational model through changing educational notion and improving educational methods.


The research are performed to check the characteristics of the ice slurry transport system for the district cooling. The system are installed at the 1st floored building which is as large as the 1204 ㎡ (86 m × 14 m). Three kinds of heat exchanger are selected, such as, plate, spiral and shell & tube type, to apply to the ice slurry systems. Experiment was done in the two cases. The first case, circulation water flow fixed at the design conditions for the state to change the flow of the supply of ice slurry. The second case, Ice slurry flow fixed at the design conditions for the state to change the flow of circulation water. Both side of Energy balance was calculated. The performance of plate heat exchanger is higher than others and it's enthalpy effectiveness is higher too.


Background and Objectives: The Kleihauer slide test is in general use to screen obstetric patients for possible fetomaternal haemorrhage. Since 1993, Rh(D)‐negative patients have been tested in our laboratory by a flow‐cytometric method detecting Rh(D)‐positive fetal cells, a method which offers improved sensitivity and accuracy. We report another flow‐cytometric method of broader application which quantitates cells according to haemoglobin F (HbF) content. Materials and Methods: The red cells are fixed with glutaraldehyde and permeabilized by exposure to Triton X‐100. A polyclonal sheep antibody to HbF is incubated with the cells followed by a fluorescein‐labelled anti‐sheep antibody. Results: Quantitation of the percentage of fetal cells following a FMH can be achieved irrespective of the blood groups of either mother or infant, and the presence of maternal F cells need not interfere since the intensity of staining is usually less than that of fetal cells. Two of 19 transfusion‐dependent patients with β‐thalassaemia have been found to have red cells indistinguishable from fetal cells on the basis of HbF content, but these patients also have been found to give positive results by the Kleihauer test. Conclusion The flow‐cytometric method may serve to replace the traditional Kleihauer test since it appears to offer improved accuracy and objectivity.


For the professional group, the short period of training applied was sufficient to improve the values of maximal, minimum and average Anaerobic Peak Power. This could be associated to a gain in strength and maximal sprint speed as well as an indication that the subjects became better in an ability to maintain the anaerobic performance. The Fatigue Index did not show significant adaptation at the rate at which power output declines for the evaluated group. Of course, these responses to training result from the workloads applied which were not controlled in this study. In the case of the Under-21 group none of the variables showed significant adaptation even with a much longer period of training when compared to the professional group. The improvement of these variables is important for soccer players and a regular assessment must be done in order to verify such adaptation. It seems that during this period of training the workloads applied were not sufficient to promote specific gains in the Anaerobic Peak Power. At this particular group this adaptation could not be observed unless the subjects of this study already were at their best conditioning. Also, these results reflect the individual characteristics of the subjects and how their body adapted to the training. On the other hand, the use of the RAST test showed to be important in the assessment of training adaptation considering its characteristics and the demands of soccer related to the multiple sprints performed during a match.


The present study provides a better understanding of the affinities between literature and
history. This is to say more explicitly that the defects assimilated to viral pathologies which
have infected the populations of Arras, the authorities (political, religious, paternal) in
particular, are similar to that which the world has known for a few months, to namely the
Coronavirus pandemic, also called the COVID-19. The new social order, which the latter
requires, justifies the focus on the aristocratic elite who happens to be in perfect connivance
with the clergy. The structural or hierarchical rearrangement of social relations accounts
for a certain weakening or annihilation of the unconditional supremacy of which this elite
claims the prerogative through courtly ideology. The downfall of the said elite infected with
viral defects allows Adam de la Halle to initiate, through his main character Adam, a
healing odyssey, under the prism of generic subversion.
This translates, moreover, in a dramatic form tested positive which rubs shoulders and
harmoniously forms one with many other literary genres of the medieval period, considered
in turn as contact cases.


Job satisfaction is one of the most significant indicators of organizational effectiveness. This paper focuses on discussions about the leading variables of transformational leadership and their impact on the ability of mid-career executives to perform their jobs. Human resources are an essential asset in developing and achieving the goals of government organizations. This study analyzes the impact of leadership on employee job satisfaction and observes the impact of corporate culture on employee job satisfaction. The study used primary data from a survey of 245 employees at the Indian Institutions of the Maros Devices' Work Unit as samples. Structural Equation Modeling applications were used to examine the research data (SEM). The proposed method describes the variable features of leadership, job efficiency organizational culture, job satisfaction, and inspiration among workers of the Regional Education Service Maros. The main goal of verification research is to examine the validity of a hypothesis that is executed in the field through data collection. The results of this study suggest that leadership has an impact on employee job satisfaction. The analysis and validation of this case via this work improve the existing idea. The obtained results show that organizational learning and transformational leadership have no substantial effect on employee efficiency, both intrinsically and extrinsically by job satisfaction. Employee efficiency is significantly influenced by job happiness. Because the analytical approach utilized is a structural equation model (SEM), which is based on the concept and theory of the partial least squares (PLS) program package, the findings are accurate. Transformational leadership has a direct and considerable effect on work happiness and corporate engagement, according to the findings of this study.


Educational projects are a structured entity containing four basic balanced elements of goal,task,organization and cost.The structures can be classified as temporal and spatial structures,and either has unique temporal-spatial structures.Only by analyzing the temporal-spatial structure in detail can we offer a distinct structural vista for the design and implementation of educational projects.


ABSTRACT Researchers agree that employers should differentiate themselves from their competitors to become the employer of choice. However, from the recruitment literature, it is not clear how employers should differentiate their employment offers. Building upon the structural alignment theory, we investigated in two experimental studies whether offering something unique (i.e., non-alignable attributes; e.g., offer a benefit package when competitors do not) or offering the same yet better (i.e., alignable attributes; e.g., offer a bigger benefit package than competitors) is the most effective differentiation strategy for employment offers and whether this depends on job seekers' work experience. Offering the same yet better affected job seekers' preferences more positively than offering something unique in lowly complex judgement and decision-making situations (Study 1) as well as in highly complex judgement and decision-making situations if job seekers had more work experience (Study 2). Hence, our findings suggest that differentiation strategies matter: employers should differentiate by offering the same yet better, particularly when they look for highly experienced job seekers in highly complex judgement and decision-making situations.


According to the Study of the Urban Development Plan developed in 2016 by the students from the Faculty of Architecture at Universidad de Las Americas, referred to as ARO-960, it was determined that the coverage range of existing cinemas in the city of Quito does not supply the Mariscal sector. It was noted that this sector is being used as a gathering and nightlife entertainment area by youngsters. The new facilities built for households in this area, as well as lifestyles changes, population growth, the inclusion of the family nucleus of the inhabitants of La Mariscal and of the public at large require new options for family and social recreation. It was therefore decided to carry out the following project: DESIGN AND CONSTRUCTION OF CINEMA HALLS After undertaking a study to analyze the geographical features of the area, we can state that the proposed project has administrative offices, four cinema halls, a cafe-restaurant, reading rooms, painting and movies exhibitions galleries, entertainment rooms, an outdoor room, a candy store, two-story parking lots, auditoria for both theatre and cinema. These facilities are to be built in an area of 4653 square meters. The aim would be to provide an alternative to the world of entertainment to all persons resident in La Mariscal as well as visitors. Moreover, the other purposes to be taken into account are: take advantage of soil's potential, promote new ventures in order to foster job creation and improve the living conditions of people, develop and stimulate cultural and social life. Arquitecture meets the needs of people's daily lives integrating activities within a given landscape.All the information we could gather from this investigation provided decisive elements for the project design and implementation.


As Nb superconducting radio-frequency cavities are now approaching the theoretical limits of the material, a variety of different surface treatments have been developed to further improve their performance, although no fully understood theory is yet available. Small superconducting samples are studied to characterize their material properties and their evolution under different surface treatments. To study the RF properties of such samples under realistic SRF conditions at low temperatures, a test cavity called quadrupole resonator is currently being fabricated. In this work we report the status of the QPR at Universität Hamburg in collaboration with DESY. Our device is based on the QPRs operated at CERN [1] and at HZB [2] and its design will allow for testing samples under cavity-like conditions, i.e., at temperatures between 2 K and 8 K, under magnetic fields up to 120 mT and with operating frequencies of 433 MHz, 866 MHz and 1300 MHz. Fabrication tolerance studies on the electromagnetic field distributions and simulations of the static detuning of the device, together with a status report on the current manufacturing process, will be presented.


Abstract : Operators rely more and more on models to accomplish their work. Examples of this include the weapons employment zone displays in cockpits, logistics models for deployment, and battle simulations to decide courses of action. They often do not have much exposure to modeling, and the products they are using do not always supply adequate documentation. The first portion of this paper serves as a primer on modeling for operators. It then proposes a matrix of questions that an operator should know to ask about any model he is using. The next section contains several examples to illustrate the discussion. The last section includes a proposal to use the matrix as a standard format for modelers to pass relevant information to users. If the operators know which questions to ask, and modelers can embed that information inside the models, then overall effectiveness should increase.


Wireless networks-on-chip (WiNoC) communications are envisioned as a promising technology to support the interconnection of hundreds of cores in the chip multi-processor design. To meet the future demand for Tera-bit-per-second (Tbps) ultra-fast links in the WiNoC, the millimeter wave (mmWave) and Terahertz (THz) bands with ultra-broad spectrum resource are proposed for WiNoC communications. In this paper, a hybrid WiNoC architecture and the stratified chip design are described, in which the flip-chip package and heat sink are considered. The electromagnetic fields in the WiNoC stratified medium are theoretically analyzed and verified with full-wave simulation. Based on the developed channel model, the WiNoC propagation is characterized by analyzing the path loss, the channel capacity and the reliability. Furthermore, the impact and guideline of the chip design on the WiNoC wave propagation are extensively evaluated and investigated. In particular, the wave propagation performance in THz WiNoC channel can be improved, by decreasing the underfill thickness, proper choice of the silicon thickness and inserting a bottom layer below the silicon substrate.


Urticaria is common in pathology. Urticaria and angioedema with persistent symptoms have a significant effect on quality of life and activity. Typical manifestations of urticaria are not difficult to diagnose. Association of urticaria with angioedema is relatively common, about 50% of cases. This association can be life-threatening requiring intensive care. Urticaria treatment is not easy and when angioedema associated therapeutic measures should be complex. Etiological treatment is the most desirable option for physician and patient, but in many cases the cause cannot be identified. Non-sedating H 1 -antihistamines are considered first-line treatment of urticaria.


Individual behavior change can serve as a key strategy for reducing energy use to mitigate greenhouse gas (GHG) emissions and improve energy security. A theory-based, school-based intervention to promote energyand GHG-saving behaviors was developed by applying strategies and approaches from prior successful work in health behavior change. The focus was on changing behaviors rather than increasing knowledge, awareness, and attitudes, making extensive use of experimentally validated behavioral theory and principles. The intervention was evaluated in a cluster-randomized controlled trial. Public high school students (N=165) in a required course were randomized by teacher to receive a five week, five-lesson behavior change curriculum promoting changes to reduce home electricity-, transportation-, and food-related energy use and GHG emissions or their usual coursework. Students reported their energyand GHG-saving behaviors at baseline and six weeks later (one-week after the completion of the curriculum for the treatment group students). Effects were tested with hierarchical linear models to account for potential clustering within classrooms. Students randomized to receive the curriculum statistically significantly increased their total energyand GHG-saving behaviors compared to controls (adjusted difference = 0.43 on a scale from 0-6 behavioral categories, 95% Confidence Interval = 0.07 to 0.80, p =.02; number needed to treat [NNT] = 4.1). The largest effects occurred in hang drying clothing (adjusted difference = .098, 95% Confidence Interval [CI] .028 to .165, NNT = 4.1) and shutting off appliances and other energy-using devices when not in use (adjusted difference = .095; 95% CI .055 to .135; NNT 3.5). These results indicate that a theory-driven, school-based classroom intervention can increase energyand GHG-saving behaviors among adolescents.


Type IV pili (T4P) are distinctive dynamic filaments at the surface of many bacteria that can rapidly extend, retract and withstand strong forces. T4P are important virulence factors in many human pathogens, including Enterohemorrhagic Escherichia coli (EHEC). The structure of the EHEC T4P has been determined by integrating Nuclear Magnetic Resonance (NMR) and cryo-electron microscopy data. To better understand pilus assembly, stability and function, we performed a total of 108 μs all-atom molecular dynamics simulations of wild-type and mutant T4P. Extensive characterization of the conformational landscape of T4P in different conditions of temperature, pH and ionic strength was complemented by targeted mutagenesis and biochemical analyses. Our simulations and NMR experiments revealed a conserved set of residues defining a novel calcium-binding site at the interface between three pilin subunits. Calcium binding enhanced T4P stability ex vivo and in vitro, supporting the role of this binding site as a potential pocket for drug design.


Death caused by cardiovascular and cerebrovascular disease is still the highest. Atherosclerosis is due to hypercholesterolemia of predisposing factor of both diseases. Curcumin has antioxidant character that can inhibit lipid peroxidase to atherogenesis process. The aim of this study was to prove the effect of curcumin to decrease total cholesterol level, LDL-cholesterol level, the amount of F2-isoprostan and the formation of foam cell in aortic wall in rats receiving atherogenic diet. To determine the effect of curcumin to decrease total cholesterol level, LDL-cholesterol, the number of F2-isoprostan and foam cell in wistar strain white rats, atherogenic diet was given for 10 weeks into 6 groups (n=24) atherogenic diet group (control), atherogenic diet group + curcumin (50 mg/kg bw per day), atherogenic diet group + curcumin (100 mg/kg bw per day), atherogenic diet group + curcumin (200 mg/kg bw per day), atherogenic diet group + curcumin (400 mg/kg bw per day), normal diet group (control). After 10th weeks, total cholesterol level and LDL-cholesterol were measured by spectrophotometry. The number of F2-isoprostan and foam cell was counted semi quantitatively by light microscope. F2-isoprostan staining was done with immunohystochemistry Avidin Biotin Complex method, and foam cell staining with HE-oil Red O. The results showed that the highest total cholesterol level was found in group I (275.15 ± 10.01; mean ± SD), the highest LDL-cholesterol level found in group I (158.15 ± 12.19). Statistically, total cholesterol level and LDL-cholesterol level in group I were significantly higher (p = 0.05) than those in other groups. Total cholesterol level and LDL-cholesterol was found to decrease in group V (93.31 ± 4.07; 19.76 ± 5.25). The highest number of F2-isoprostan was found in group I (5.5 ± 1.29). The highest foam cell was found in group I (3.5 ± 1). Statistically, the number of F2-isoprostan and foam cell in group I were significantly higher (p = 0.05) than those in other groups. The number of F2-isoprostan and foam cell were found to decrease in group V (1 ± 0.82 ; 0.5 ± 0.58). In conclusion, curcumin has effect in decreasing total cholesterol level, LDL-cholesterol, number of F2-isoprostan and the formation of foam cell significantly in rats with atherogenic diet. The administration of curcumin in a dose of 400 mg/kg bw daily is more effective in decreasing total cholesterol level, LDL-cholesterol, number of F2-isoprostan and the formation of foam cell than in other 3 doses of curcumin.


Guided by the requirement changing of innovation, every country is frequently adjusting development strategy to reconstructing the information service. This paper takes the method of document analysis to study the research and practice of information service transformation in different countries and find the concerns of scholars and the trend of modern information service industry development. Objectively speaking, nowadays research on information service transformation is lagging behind the practical development. The academic field hasn't put enough focus on the problems came out of the transformation process, and rarely make innovations. The research contents are over emphasized on the technology, while the research on management system, operation system and relative principles are insufficient.


Kawasaki disease (KD) is an acute vasculitis of unknown etiology, however, some studies suggest that superantigens are involved in its pathogenesis. To clarify an association between KD and bacterial infection, we studied bacterial culture supernatants from throat flora of acute stage KD patients for mitogenic activity. Twenty-five individual bacterial strains (Streptococcus sp., Stapylococcus sp., Neisseria sp., Pseudomonas sp. etc) were isolated from throat of nine acute-stage KD patients before treatments. Each of these bacterial strains was cultured overnight at 37centigrade in trypticase soy broth. Bacterial cells were removed by centrifugation and filtration with a 0.22μm pore size filter. The mitogenic activity in the supernatants was determined by a three-day lymphocyte assay. Fresh peripheral blood mononuclear cells (PBMC) were obtained by ficoll-paque centrifugation of heparinized blood from healthy adult. PBMC were cultured in RPMI 1640 containing 10% heat-inactivated fetal bovine serum. The bacterial culture supernatant (10μL) was added to the PBMC culture (105 cells in 0.1 mL of culture medium) and then cultured in each well of a 96-well microplate at 37centigrade in 5% CO2. Proliferation of PBMC was determined three days after by morphological observation and Cell Counting Kit-8 (Dojin Chemical). The mitogenic activity for human lymphocytes was observed in three of twenty-five supernatants. The three supernatants were contained two strains of S. pyogenes and one strain of methicillin-resistant S. aureus. The results indicate that at least three of nine acute-stage KD patients had bacteria producing mitogenic products in throat flora. These findings support the involvement of mitogenic products, such as superantigens, of group A streptococci and S. aureus in the pathogenesis of KD.


The Indian spiny lobster, Panulirus hnmarus (Fig. 1) and allied species, has
come to the lime-light during the past decade due to the great demand in foreign countries
as a favourite of epicurean gourmets. Exploitation of the spiny lobster resources of the
country, mainly from the south-west coast of India, which remained as a subsistence fishery
for the local fishermen till recently has now developed into a more profitable venture
encouraged by the marine products export industry. The edible part of the spiny lobster is
known to the industry and consumer by the term "lobster tail". Today the frozen lobster
tails from India are available in most of the world markets and as such it has become an
important commodity earning valuable foreign exchange for the country.


The Extra-dosed cable-stayed bridge is considered as a new popular type of bridge structure in recent 20 years, whose mechanical properties and economic span both lie between continuous beam (or rigid frame ) bridges and cable-stayed bridges. This design is a double-cable-plane (85+150+85) m prestressed concrete Extra-dosed cable-stayed bridge, whose maximum Design speed is 100km/h and its width is 25.50m. The form of the highway is sextuple line which is 10.75m far away,and the cross-sectional slope is 2%. The girder body adopts three cell and single box, the height of beam takes quadratic parabola relation, which is 5m high at the middle support, while at the side support and the midspan is 3m. Vehicle standard load was applied on the bridge. The design uses Midas/Civil to establish the finite element model that is reasonable and simple, analyzing the structure behavior of the girder body under loading, especially the internal forces of bridge structure under dead load, live load and additional force.


Studying applications of mathematics, economics and behavioral sciences for various problems in business education seems to be prerequisite because its applied nature is obvious. So far, the public sector management and the decision making manner in this sector significantly differed from the private sector. However, public management has undergone significant changes nowadays, mainly due to more and more complex contemporary decisional problems it must face. Obviously, managerial cognitive capabilities can be taught, and have been taught in business education for years. The question arises if it is possible to adopt selected experiential techniques of pattern recognition, interconnected thinking and holistic learning, already successfully utilized during classical managerial training, to the betterment of the public sector management. The answer to this question constitutes the objective of this examination.


A new row-based parallel algorithm for standard-cell placement targeted for execution on a hypercube multiprocessor is presented. Key features of this implementation include a dynamic simulated-annealing schedule, row-partitioning of the VLSI chip image, and two novel approaches to control error in parallel cell-placement algorithms: (1) Heuristic Cell-Coloring; (2) Adaptive Sequence Length Control.


This article is devoted to the description of resource ensuring conversion of system of utilization of chemical weapon. In article the main problems which concern the public at the choice of the directions of conversion of objects for utilization of chemical weapon are in detail analyzed. Besides the optimum choice of mechanisms of a reshaping of objects for utilization of chemical weapon is considered. Special attention is paid to the description of a number of projects on conversion and types of sources of financing of implementation of these projects. The author resource base of objects for utilization of chemical weapon which can be used for release of demanded competitive production of defensive or civil appointment in detail reveals. According to the author, objects up to the EAR as the chemical companies of defense industry complex possess high degree of investment appeal. The author connects this statement with presence at OUHO of a number of the resources necessary for release of demanded competitive production of defensive or civil appointment. On the basis of the analysis of the current state of a chemical complex of Russia which is carried out in this article, the author has come to a conclusion that objects for utilization of chemical weapon will allow to increase resource potential of both defense industry complex of the Russian Federation, and her chemical and petrochemical industry.


This paper is mainly focused on the sheet, tool and lubricant characteristics that largely affect the friction coefficient in stamping operations. As a matter of introduction, the simulative tests used in this research are briefly described. Then, the extremely important role of the sheet and tool roughness is underlined and the way these factors act on the lubrication regime during press forming is highlighted. The lubricant is taken into account by means of the viscosity and the amount of oil present on the sheet. Finally, a theoretical model adapted from the Stribeck curve is developed as a basis for the implementation of a general friction algorithm in the FF.M codes.A second part is related to the evaluation of the tool material effect on galling. A methodology, based on laboratory simulative tests backed-up by industrial trials allows to derive practical rules to better control the frictional conditions and avoid galling.


One of the important aspects of the crisis management consists in a comprehensive analysis of the impacts generated and their associated cost. The capacity to carry out an efficient holistic management, through the development of preventive measures and response programs relies on a proper estimation of impacts which helps to mitigate the harshness or can even avoid impacts in face of future crises. The aim of this paper is to analyse existing methodologies for natural disasters' impact evaluation, the identification of the different impact categories as well as the explanation of a natural disasters impact framework, which includes a list of indicators for a correct impact assessment. The framework also analyses the evolution of impacts, that is, how immediate impacts can also generate delayed impacts.


The proposed experiment is based on the hypothesis that the development level of psychomotor capacity of students with mental disability is, in the absence of a psychomotor educational program, below that of their biological age. We evaluated the psychomotor ability by using Guillmain Ozeretsky and Piaget-Head tests,in order to validate the hypothesis and to obtain the psychomotor diagnosis of the students with mental deficiencies. I found by descriptive statistical methods that the research hypothesis was accepted with a probability of 95%. We observed an average difference of 3 years between biological age and psychomotor age at students with mental deficiencies.


The genesis and progress of Mongolian literature provides an expansive cultural circumstance for the studying of the comparative literature.During categorizing and summarizing the progress of Mongolian literature with his original mind Ts·Damdinsuren studied the difference between Mongolian literature and foreign literature in multi-levels and putted forward a theme of translation of Mongolian literature and its localization which is of great importance for the historical exploration of the relationship of Mongolian literature,the writing the history of ancient Mongolian literature and the studies of comparative literature in Mongolia.In order to clarify the main idea of Ts·Damdinsuren's thoughts for the translation of Mongolian literature and its localization,this article takes a work,namely the Diffusion of Ramayana in Mongolia as an example,expatiates the studies of the localization of Ramayana in Mongolia.


Abstract S5.1 Antifungal resistance, September 22, 2022, 3:00 PM - 4:30 PM Resistance to clinical antimycotics in Aspergillus fumigatus has become an increasing threat in healthcare worldwide over the past two decades. Factors that contribute to this continuing trend are manifold, among others resistance emerge in environmental fungi through selection pressure due to fungicides widely used in agriculture and farming, resistant clones are diffused around the world through global travel and shipping routes, as well as prophylactic and long-term administration of antifungal agents in patients with chronic fungal disease creating selection pressure.   Physicians face particular challenges in their patients with invasive aspergillosis, with emerging resistance adding another layer of therapeutic complexity. We are beginning to gain an understanding of the clinical implications of the different patterns of resistance. First international studies have shown that resistance of A. fumigatus to clinical antifungal agents significantly hampers the successful treatment of patients.   This presentation aims to highlight the difficulties associated with antifungal resistance in A. fumigatus with a focus on hematological oncological patients.


PAGE In the past, the issue of slavery and racism in New Englnad has been largley ignored. Towards the end of the twentieth century this issue has been revisited by a num ber of scholars. Their research has shown that slavery w as common in New England during the colonial era and that African Americans were discriminated against and econmicaly oppressed throughout the early national period a s well. Two archaeolgical sites in New England were examined in order to ascertain whether double consiousness a s defined by W.E.B. Du Bois may be visible in the archaeological record of these two sites. The first site is a colonial quarter for enslaved people in Medford, M assachusetts. The second site is the rem ains of an early ninteenth century tenant house in Saunderstown, Rhode Island. The examination of the artifacts and their contexts found at the two sites has found that it is likey that although both sites were from two different time periods and the inhabitants of the sites faced different situations, there is evidence that double consiousness w as present in how the sites' inhabitants percieved the world around them.


Background: For patients with hepatocellular carcinoma (HCC) who are undergoing potentially curative surgical resection or local ablation, 5-year recurrence rates are up to 50%-80%; there is no standard of care for adjuvant treatment. The programmed death 1 inhibitor pembrolizumab is approved for the treatment of patients with HCC previously treated with sorafenib. There is no direct evidence of benefit with pembrolizumab in the HCC adjuvant setting, but a favorable benefit/risk profile is anticipated based on data from other indications. KEYNOTE-937 (NCT03867084) is a randomized, double-blind, phase 3 trial to examine the safety and efficacy of adjuvant pembrolizumab versus placebo in patients with complete radiologic response after surgical resection or local ablation of HCC. Methods: Eligible patients are aged ≥18 years and have confirmed HCC, complete radiologic response after complete resection or local ablation, Eastern Cooperative Oncology Group performance status of 0, and class A Child-Pugh score. Patients with past or ongoing HCV or controlled HBV are eligible if they meet certain criteria. Patients (N~950) will be randomly assigned 1:1 to receive pembrolizumab 200 mg or placebo every 3 weeks and stratified by geographic region, prior local therapy (resection vs ablation), recurrence risk, and alpha-fetoprotein level at diagnosis. Treatment will continue for up to 17 cycles (~1 year) or until documented disease recurrence, unacceptable toxicity, or investigator/patient decision to withdraw. Dual primary end points are recurrence free survival (RFS) and overall survival. Secondary end points are safety, tolerability, and quality of life. Exploratory end points include distant metastases-free survival (DMFS); time to recurrence (TTR); and genomic, metabolic, and/or proteomic biomarkers. RFS, DMFS, and TTR will be assessed radiographically by the investigator and/or by subsequent biopsy and confirmed by blinded independent central review. Adverse events (AEs), graded per National Cancer Institute Common Terminology Criteria for Adverse Events version 4.0, will be recorded up to 30 days after last dose (90 days for serious AEs). Citation Format: Andrew Zhu, Masatoshi Kudo, Arndt Vogel, Thomas Yau, Jian Zhou, Eunhee Kim, Usha Malhotra, Abby B. Siegel, Ann-Lii Cheng. Phase 3 KEYNOTE-937: Adjuvant pembrolizumab versus placebo in patients with hepatocellular carcinoma and complete radiologic response after surgical resection or local ablation [abstract]. In: Proceedings of the Annual Meeting of the American Association for Cancer Research 2020; 2020 Apr 27-28 and Jun 22-24. Philadelphia (PA): AACR; Cancer Res 2020;80(16 Suppl):Abstract nr CT284.


When the Spanish colonial government escalated the war with Cuban independence forces by sending Valeriano Weyler "the Butcher" to contain the conflict, many emigrated from Cuba to to join the community in Tampa. Gálvez describes the process to obtain a passport, the voyage to Port Tampa via the steamer Olivette, a stop in Key West, and arrival in Ybor City.


■ This paper attempts to explain the variation of foreign market entry mode choice in the service sector, by taking into account the unique characteristics of service firms. ■ Using "market knowledge" as a determinant of entry mode choice, the paper develops some hypotheses concerning entry mode choice in service firms; these are empirically tested.


In accordance with an embodiment of the present invention, the intelligent image quality engine intelligently manages different parameters related to image quality in the context of real-time capture of image data, in order to improve the end-user experience by using awareness of the environment, system, etc., and by controlling various parameters globally. Various image processing algorithms implemented include smart auto-exposure, frame rate control, image pipe controls, and temporal filtering.


The legal act concerning the village fund was enacted 20 th February 2009. Although it is not perfect, it gives another instrument for the development and the stimulation of local communities. The success of the new regulation in large measure depends only on communes themselves, which should use them in a reasonable and constructive way


We examine the interaction of a weak probe with N atoms in a Lambda-level configuration under the conditions of electromagnetically induced transparency (EIT). In contrast to previous works on EIT, we calculate the output state of the resultant slowly propagating light field while taking into account the effects of ground state dephasing and atomic noise for a more realistic model. In particular, we propose two experiments using slow light with a nonclassical probe field and show that two properties of the probe, entanglement and squeezing, characterizing the quantum state of the probe field, can be well-preserved throughout the passage.


Objective To explore the role and clinical value of ureteroscope in the treatment of urethrostenosis.Methods Ureteroscope was used in the treatment of 26 cases of urethrostenosis to find out the right leading direction,dilate the stenosis site and trmain the urethral label.The stenosis site was cut open and urethral catheters were remained.After operation,ureteroscope was used in urethral dilation.Results Twenty-five cases had successful urethral catheter indwelling during operation,24 cases could micturate normall and 2 cases failed.Conclusion Ureteroscopy can increase the curate rate in the treatment of urethrostenosis.


A cascade Michael-hemiacetalization reaction between β-substituted β-nitroethanols and α,β-unsaturated aldehydes is described, which provides a convenient and efficient synthesis for cis-δ-lactols with quaternary stereocenters in moderate yields with excellent enantioselectivity. Based on the selective precipitation of cis-δ-lactols, which were isolated by filtration, the catalytic system in the filtrate can be reused directly and recycled for eight times without any obvious deterioration in enantioselectivity.


This paper presents multi-processing implementation of video de-noising algorithms based on Least Square Estimation (LSE) and Best Linear Unbiased Estimation (BLUE). Real-time processing was achieved using multiple Digital Signal Processors (DSPs) and tested on video images with low Signal-to-Noise ratio (SNR). The imaging device used to perform the vision-processing tasks is the Matrox Genesis, which consists of on-board processing, frame grabber and display modules. Texas Instruments' TMS320C80 Multimedia Video Processor (MVP) that runs at 50 MHz is employed to perform the signal processing task.


The paper presents an application of dynamic programming to the identification of optimal parameters of tree-structure energy pipeline networks. The identification of the optimal parameters of tree-structure energy pipeline network is as follows: the determination of pipeline diameters; the determination parameters and locations of pumps. The paper highlights the following main cases of this problem: identification of optimal parameters of a new pipeline networks to be designed; optimization of an existing pipeline networks to remove bottlenecks; ensuring of optimal transmission capacity for an expanding existing pipeline network. A unified conceptual and mathematical statement of the problem, covering all the cases of the above problem, are presented. The algorithm for identifying tree-structure energy pipeline networks that were proposed in the paper have been developed at the Melentiev Energy Systems Institute of Siberian Branch of the Russian Academy of Sciences within the framework of the hydraulic circuits theory. The developed methodological support can be applied to design of tree-structure energy pipeline networks.


The optical ray retracing of stimulated Brillouin backscatter from a laser fusion plasma has been studied, including the effects of density gradient and flow velocity and allowing the acoustic wave to be weakly damped. The pump is comprised of two plane uniform beams propagating at some angle with respect to each other, producing an interference pattern that behaves as an active grating for the scattered radiation. When the convective loss due to plasma inhomogeneity is small, Bragg diffraction of the scattered radiation results in the reproduction of the same transverse spatial structure as the pump, i.e., the two beams are retraced. However, when the convective loss dominates, the Bragg diffraction is severely affected and the scattered radiation no longer reproduces both beams of the pump with equal intensities or in the correct backward directions.


Fruit anthocyanins provide color and health benefits, thus cereals containing these pigments could be used as functional foods. White corn meal with 10% sucrose was twin-screw extruded with either corn syrup, lowbush blueberry concentrate, or Concord grape-juice concentrate. Extrusion reduced anthocyanins, but there was no change due to storage at room temperature for 3 mo. Polymeric color was higher in the blueberry cereal. The grape cereal was lighter and less red than the blueberry product. Bulk density was highest in the corn-syrup cereal. Overall acceptability was higher for the syrup and grape cereals. Sweetness and flavor acceptability were correlated with overall liking.


This research focuses on evaluating the image of hotels in the strategic management process, filling in the theoretical and methodological gaps related to the management of this intangible resource. It provides a conceptual model that explains how the image of a hotel is determined by subjective and objective factors. Another result of this research is the procedure proposed, where the measuring instruments that make it up are applied to 1395 respondents and subjected to the criteria of experts in order to scientifically verify that with the evaluation of the image in the strategic management of hotels in Cuba it is possible to achieve their desired image. This study also presents, in a complete way, the application of the proposed procedure in the hotel: Brisas Trinidad del Mar.


This article provides an update on attempts to tax the imputed rental income of owner-occupied residences under foreign income taxes and a commentary on the nature of foreign experiences with attempts to tax this form of personal income.


Decision-making is a function of the first importance to the leading work,and scientifically decision-making is an important question faced by every leading cadre.Subjectively speaking,the function of leaders'scientific decision-making is a central content,which gives expression to every aspect in practic.Establishing a complete decision-making system is the objective guarantee of scientific decision-making.


In this paper,the multiple influence in the aspects of busbar voltage regulation,system network loss,power transmission channel loss and power transmission capacity of the related substation with the SVC/DC de-icer and SVC device in Dushan substation under different operation duty of the SVC mode,the coordination control of the DC de-icer and SVC device and reactive power installations inside the substation are calculated and analyzed.The coordination control strategy is given to achieve coordination control and economic operation of reactive resources in the substation.The research result in this paper is helpful to reduce the loss of the device itself and its network,and will produce significant economic efficiency,not only provide reference to the design and production of similar equipment in the future,but also provide technical support in improving operation management level,saving energy and reducing loss of such equipment.


The invention relates to improvements in the link initialization process, and for the exchange of system error information, to provide a system and method for implementing a cyclic redundancy check. In one aspect, the unique pattern detector, CRC generator, CRC initializer, and CRC a cyclic redundancy check (CRC) checker comprising verifier is provided. CRC checker advance implement CRC generator for unique pattern. When acquiring the unique pattern in the received data stream in which the digital transmission link, CRC checker advances the check without the need CRC to queue and store data. In another aspect, destroying intentionally CRC value to transmit system error information (corrupt) CRC generator system is provided. The CRC generator system, CRC generator, CRC Koraputa (Corrupter), and includes an error detector, and an error value generator. In one example, the digital transmission link is an MDDI link. .BACKGROUND 9


Corrosion is mostly considered as homogeneous thickness reduction in construction guidelines of the maritime industry. Several studies concluded that besides a homogeneous thickness reduction the corroded non-uniform surface morphology is affecting the strength and strain behavior of steel. However, the effects of non-uniform corrosion on the behavior of steel is still not clearly assessed.
 The effects of corrosion on the local behavior of steel structures under tensile loading were investigated by conducting tensile tests on naturally corroded steel specimens and analyzing the surface morphology based on surface scans. Influences of geometrical parameters on the strength and strains were determined by carrying out a correlation analysis combined with a Particle Swarm Optimization. Then a non-linear finite element analysis was performed to compare a homogeneous idealization with finite element models considering the naturally corroded surface morphology.
 Both independent approaches conclude that non-uniform corrosion leads to a more brittle stress-strain behavior of steel compared to a homogeneous corrosion approach, including higher stresses and decreased total breaking strain. In addition we can confirm that pittings and surface roughness are leading to a decrease of the total breaking strain. In contrast to many other studies we highlighted that instead of the pitting corrosion in general, the volume or thickness loss are the primary driver for the ultimate tensile strength reduction.


: Machine Learning and Deep Learning tools in Medical Imaging are promising approaches to aid physicians and radiologists in performing diagnoses. Machine Learning models that work with imaging data require massive amounts of data. Although many institutes are collaborating to produce publicly available datasets of medical images, the process of data acquisition is severely limited by different challenges. These challenges are mainly related to privacy regulations and the effort of domain experts to assess imaging data quality and produce high-quality ground truth. In turn, the difficulty of managing large datasets of medical imaging translates in a scarcity of data available for research. This Ph.D. thesis studies collaborative machine learning as a methodological approach to overcome the problem of data availability. Collaborative Machine Learning is a vast area of research that includes a set of techniques, such as Distributed Learning and Esembling Methods, to enable multi-centric studies using multiple private datasets. The main idea behind collaborative machine learning is to share knowledge instead of data to overcome potential privacy issues in exchanging sensitive data. However, this approach poses challenges that include data heterogeneity due to the population included in the datasets, and data incompleteness, due to different data acquisition standards and practices among different institutions. This work provides a general taxonomy for classifying the various approaches proposed in the literature and analyzes well-established techniques such as ensemble learning and transfer learning in the context of collaborative machine learning. Moreover, we analyze more recent contributions based on Federated and Split Learning, comparing their performances according to data heterogeneity and privacy constraints. Our experiments study multiple approaches that exploit ensemble methods, distributed learning, and transfer learning to overcome different challenges, such as data heterogeneity, model heterogeneity, and label heterogeneity using public and private datasets. Finally, we propose our approach to image segmentation based on adversarial networks and generative adversarial networks to study possible approaches to the problem of incomplete medical imaging datasets. The results are promising, showing that collaborative learning can successfully context of data heterogeneity. Transfer learning and embedding techniques can enable the training of custom models on smaller private datasets by exploiting the powerful feature extraction modules of Convolutional Neural Networks. Lastly, our approach based on adversarial networks proved to be promising to enable the use of multi-input segmentation models when some of them are missing, thanks to image translation.


Differences in susceptibility to N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) of fundic mucosa in various states of regeneration after induction of ulcer with iodoacetamide were examined histologically in male Wistar rats. Iodoacetamide was given to rats in their drinking water, before (Group 1), with (Group 2), or after (Group 3) MNNG. Atypical hyperplasia in the renewed mucosa and pyloric gland metaplasia were observed on the ulcers in Group 1 in higher incidence than in Groups 2 and 3. In addition, adenocarcinoma developed in the ulcer of 2 of 17 effective animals in Group 1. These observations suggest that the mucosa showing pyloric gland metaplasia is more susceptible to MNNG than the young rapidly regenerating mucosa at the margin of ulcers.


This manual presents information on procedures and materials for prestressed pavement construction that differ significantly from those used with conventional pavements. Figures illustrate details of bulkhead construction, anchorage assemblies, jacking accessories, and joint hardware placement. The manual may be used to supplement standard specification for concrete pavement construction. (FHWA)


The concept of creating a digital field in the educational process, implemented in the Gubkin Russian State University of Oil and Gas, is presented. The structure of the hardware-software complex, simulating the behavior of hydrocarbon deposit in the process of its development, is shown. An organization diagram of the educational process, implemented on the basis of the digital field, is given


The authors describe a case of a bone scan in which a large intrapelvic tumor that occupied the middle and left side of the pelvis displaced the urinary bladder superolaterally to the night side. The pattern of pelvic uptake 3 hours after injection was unusual, mimicking a tumor or heterotopic bone formation. Subsequent 20-hour delayed imaging and blood-flow and blood-pool images helped clarify the nature of the uptake pattern as secondary to a displaced urinary bladder. This was confirmed subsequently by CT and MRI studies. The urinary bladder is known to mimic real disease on bone scans. Significant displacement of the urinary bladder should be considered when bone scans are interpreted, particularly in patents with pelvic or peripelvic tumors.


461 Background: Studies suggest that delayed adjuvant chemotherapy (AC) beyond 8 weeks is associated with inferior survival in early-stage colon cancer (CA). The optimal TTAC in rectal CA remains unclear. The objective of this study was to determine the prognostic effect of TTAC in stage II and III rectal CA treated with standard preoperative (op) chemoradiation. Methods: Patients with stage II/III rectal CA treated with pre-op chemoradiation, received post-op AC, and referred to the British Columbia Cancer Agency between 1999 and 2008 were included. Univariate and multivariate analyses were conducted using Kaplan Meier and Cox regression methods to evaluate the association between TTAC and outcomes. X-tiles cut-point analysis was performed to determine the optimal TTAC. Results: A total of 327 eligible patients were identified: median age 61 (range 22-85), 70% male, and 75% stage III. In terms post-op AC, 51% received 5-fluorouracil (5-FU), 32% received capecitabine, 12% received 5-FU and oxaliplatin, an...


It introduces the physicochemical property of fly ash and its utility in civil engineering,culture,environment protection,rare metal etc,and puts forward the problems existing in the fly ash resource combined utility and it's solving steps.


The quality of green open space in DKI Jakarta is far from perfect. The management of maintaining Green Open Space which is still dominated by the government, especially in public parks, causes more than 50% of parks to be poorly maintained. Research Objectives are to provide management strategies to maintain public parks that involve the community (non-government) so that the park can benefit the community and the environment. Several studies in Europe revealed that community involvement can increase park maintenance activities, so the quality of the park can be improved. Research methods are using observation and descriptive qualitative analysis. Data is collected through a two-way assessment matrix of the Leopold Method to the parties that will be involved (purposive sampling). Matrix formulation is done through Delphi analysis, from the results of in-depth discussions related to the results of previous research studies with the government involved in maintenance activities. The results showed that maintenance activities require the rule of law, synergy, transparency, the possibility for community participation, and Human Resources. With this strategy, it is hoped that public parks can function sustainably for the community and the environment. Keyword: Maintenance management strategy; Public parks; Sustainable Green Open Space


In this paper a novel data integration approach based on three environmental Sensors - Model Networks (including the Bureau of Meteorology-SILO database, Australian Cosmic Ray Sensor Network database (CosmOz), and Australian Water Availability Project (AWAP) database) has been proposed to estimate ground water balance and average water availability. An unsupervised machine learning based clustering technique (Dynamic Linear Discriminant Analysis (D-LDA)) has been applied for extracting knowledge from the large integrated database. The Commonwealth Scientific and Industrial Research Organisation (CSIRO) Sensor CLOUD computing infrastructure has been used extensively to process big data integration and the machine learning based decision support system. An analytical outcome from the Sensor CLOUD is presented as dynamic web based knowledge recommendation service using JSON file format. An intelligent ANDROID based mobile application has been developed, capable of automatically communicating with the Sensor CLOUD to get the most recent daily irrigation, water requirement for a chosen location and display the status in a user friendly traffic light system. This recommendation could be used directly by the farmers to make the final decision whether to buy extra water for irrigation or not on a particular day.


Product counterfeiting and tampering pose a threat to practically all famous brands. Yet there are innovative authenticity protection solutions available for tamperand counterfeit-proof product identification and labelling. They help to protect brand owners from an erosion of brand image as well as from unjustified warranty and product liability claims. In addition, they allow both consumers and experts to perform reliable authenticity verifications. This issue of our "Forum Special" contains selected case studies from the wide range of Schreiner ProSecure's solutions currently being used in the field.


Following the publication of the 2006 wanless report, the government has created a working group to assess future funding issues for social care. Beccy Sims reports.


The titular collective enterprise does not satisfy the essential legal requirements for the set_up of a corporatian,so it does not have corporate capacity.The investors are supposed to bear unlimited liability for its obligation if there exists casual relation between the illegal conducts of the actual enterprise applying for the lisense in its own name and discharging the claimant's obligatory right,the investors should also bear unlimited joint and several liability.


The Atlanta Journal-Constitution has done a review of cheating on tests in school districts across the country. The results aren't pretty.A tainted and largely unpoliced


The tidal influence of a massive galaxy on a non-rotating spherical companion is studied using numerical simulations. The simulations use various values of mass ratio and velocity of collision while the pericentric distance is kept constant. The half-mass radius of the final equilibrium system remains almost the same as that of the initial system with which the simulations started. The central region becomes more compact and the outer region shows expansion. Maximum tidal distension is observed when galaxies undergo collision on parabolic orbits. The surface density profile of the remnant follows an r 1/4 law up to r = 4R h , where R h is the half-mass radius