The utility model discloses an electrocoagulation tweezers support with a cleaning function. The electrocoagulation tweezers support is characterized by comprising a base, wherein the base is provided with grooves matching two tweezers rods of a pair of electrocoagulation tweezers, and a cavity for containing tweezers points is arranged below the grooves and is internally provided with an ultrasonic cleaner; and the support is internally provided with a liquid inlet and a liquid outlet of the cavity, the liquid inlet is connected with a liquid feeding pipe and the liquid outlet is connected with a liquid discharging pipe. The electrocoagulation tweezers support with the cleaning function, disclosed by the utility model, has a simple structure, the pair of electrocoagulation tweezers can be directly inserted into the grooves of the supporter after being used, and the tweezers points are embedded in liquid of the cavity so that the ultrasonic cleaner starts running to clean the tweezers points. When being used at next time, the pair of electrocoagulation tweezers is directly pulled out for using so that a cleaning operation of a user is greatly simplified.


Taking the investigation on a Jiangsu quarrying base environment geology problems,this thesis proposes governing measures and protective methods for the quarrying base environment geology problems,which includes solid waste storeage,land reclamation,and landscape and ecological restoration etc.Therefore,it has certain guiding significance for similar mining.


The aim of this paper is to present a bibliometric overview of the academic research on the establishment of motivation and Human resources practices and their influence on innovation, which has gained a wide acceptance in the scientific community. This analysis uses two main approaches, namely performance analysis and scientific mapping. The first uses a range of bibliometric measures and indicators to assess the importance, impact and quality of publications in a particular field. While the second aims to complete the analysis of performance using techniques from a time perspective. We have included performance analysis and science mapping of the Human Resources Motivation Field using the R language and R-STUDIO software to map the bibliographic material. We firstly have compiled a list of 1513 articles selected from the Web of Science database. Then we identified the most global relevant documents in the field according to authors, journals, articles, institutions and countries. Based on the results obtained during the analysis of these articles, it turned out that research in the field of human resource management tends much more towards digitization and the use new technologies when it comes to its link with innovation. Our conclusion is that research in this field has made significant progress in the past five years, China is the country with the greatest influence in all aspects of this field. However, it is important to consider that science is constantly advancing in this field, and data will change rapidly over time. Therefore, this work plays an informative role, showing that most of the basic research on human resources motivation is in the business and management fields.


C19H16N8, monoclinic, P21/n (no. 14), a = 13.4483(4) Å, b = 10.0263(3) Å, c = 13.9379(4) Å, . = 111.986(2)°, V = 1742.7 Å, Z = 4, Rgt(F) = 0.048, wRref(F) = 0.118, T = 298 K. Source of material The title compound, 1-bis[(2-phenylazo)imidazol-1-yl]-methane, was prepared by using the phase-transfer organic synthesis method. 2-Phenylazoimidazole (0.68 g, 4 mmol) was added to a single-neck flask, then KOH (0.24 g, 4 mmol) and Bu4NBr (0.1 g, 0.3 mmol) was added. After mixing, 10 ml CH2Cl2 was added and stirred at room temperature for 2 days. The solvent was removed in vaccum and the solid resident was subjected to flash column chromatography. Orange-yellow single crystals suitable for Xray analysis were obtained by the slowly evaporation of the solution of ethyl acetate and petroleum ether. Discussion Polyazolylmethanes have attracted considerable attention in the fields of biochemistry, materials, heterocyclic and coordination chemistry [1,2]. Recently, some inorganic-organic hybrid compounds based on the ligand bis(imidazol-1-yl)methane have been documented [3,4]. The crystal structure analysis shows that there are two phenylazoimidazole moieties in an asymmetric unit. The azo group, benzene and imidazole ring in each phenylazoimidazole moiety are planar with the mean deviation of 0.0049(2) Å and 0.0078(2) Å, respectively. The dihedral angle between the two least-squares planes is 62.2°. The N=N bond lengths are 1.260(2) Å and 1.229(2) Å, respectively, which is smaller than a similar compound [Ag(3'-PyaiEt)]2(NO3)2 with the N=N bond length being 1.248(7) Å [5]. The bonding strength between azo-N1 and phenyl [d(C6—N1) = 1.428(2) Å and d(C14—N8) = 1.452(2) Å ] is weaker than that of azo-N2 and imidazole [d(C7—N2) = 1.391(2).Å and d(C13—N7) = 1.407(2) Å]. This suggests that the extent of orbital overlap is more between azo and imidazole moieties than between azo and phenyl moieties to form a C—N !bond. The two phenylazoimidazole moieties in the same molecule were connected by the -CH2group in anti-conformation. Z. Kristallogr. NCS 224 (2009) 301-302 / DOI 10.1524/ncrs.2009.0133 301 © by Oldenbourg Wissenschaftsverlag, München Crystal: orange-yellow block, size 0.10 × 0.10 × 0.16 mm Wavelength: Mo K0 radiation (0.71073 Å) &: 0.88 cm−1 Diffractometer, scan mode: Bruker SMART CCD, +/1 2"max: 52° N(hkl)measured, N(hkl)unique: 14822, 3435 Criterion for Iobs, N(hkl)gt: Iobs > 2 !(Iobs), 2297 N(param)refined: 244 Programs: SHELXS-97 [6], SHELXL-97 [7], SHELXTL [8] Table 1. Data collection and handling. H(1) 4e 0.4759 0.7340 0.9150 0.066 H(2) 4e 0.3494 0.5669 0.8634 0.081 H(3) 4e 0.2837 0.4750 0.9803 0.089 H(4) 4e 0.3437 0.5521 1.1472 0.086 H(5) 4e 0.4688 0.7200 1.1998 0.069 H(8) 4e 0.8386 1.1790 1.2258 0.074 H(9) 4e 0.8444 1.1851 1.0529 0.067 H(10A) 4e 0.7118 1.0893 0.8735 0.060 H(10B) 4e 0.6225 0.9910 0.8770 0.060 H(11) 4e 0.6685 0.7393 0.9030 0.072 H(12) 4e 0.8012 0.6020 0.8707 0.082 H(15) 4e 1.0627 1.0999 0.8207 0.074 H(16) 4e 1.1555 1.2755 0.7865 0.078 H(17) 4e 1.1090 1.4926 0.8066 0.073 H(18) 4e 0.9752 1.5330 0.8684 0.082 H(19) 4e 0.8832 1.3583 0.9027 0.080 Table 2. Atomic coordinates and displacement parameters (in Å). Atom Site x y z Uiso


It is very important for the judge to manage the presumption of reality in the civil trial.It can help judge the reality of the case.This article expounds concept of the presumption of reality and analyzes the philosophical and practical meaning,advancing a series of conditions that must satisfy the needs in testifying and satisfy the normal connection with the basic facts when the presumption of reality is applied in the judgment.


In order to provide a complete, accurate set of atomic data for interpreting spectra provided by missions such as XMM-Newton, the Chandra X-Ray Observatory, and Astro-E2, we have harnessed the Lawrence Livermore National Laboratory's electron beam ion traps EBIT-I, EBIT-II, and Super-EBIT for laboratory astrophysics. In support of this work we have developed a number of unique techniques, including the ability to experimentally simulate a Maxwellian distribution of electron energies and measuring low-energy charge exchange cross sections using the ''magnetic trapping mode''. We have also built, and operated a full suite of spectrometers spanning the 1-7000 {angstrom} wavelength band, the most recent, being the NASA/Goddard Space Flight Center's Astro-E 6 x 6 engineering spare microcalorimeter array. Results of our efforts include a complete list of wavelengths of the Fe L-shell transitions, measurements of absolute and relative cross sections for direct, impact, dielectronic, and resonance excitation, and measurements of low energy charge transfer reactions. A brief overview of the LLNL, ebit facility, its capabilities, and some results will be discussed.


This paper expounds the purpose and significance of developing automatic generation control(AGC) for power grid frequency control,introduces its working principle,software and hardware system configuration,and analyzes the system function in detail.Through the system test of the AGC,including function testing and performance testing,this paper gives a conclusion,which is of important practical value for implementing a test for diagnosis and data analysis of the AGC.


InxCo4Sb12 skutterudite compounds have been prepared successfully at different synthesis pressures by high pressure and high temperature (HPHT) method, the processing time has been reduced from a few days to half an hour. In addition, the effect of synthesis pressure on the thermoelectric properties of In0.4Co4Sb12 compounds has been investigated in this paper. The structure of In0.4Co4Sb12 samples was evaluated by means of X-ray diffraction and scanning electron microscopy (SEM). The Seebeck coefficient, electrical resistivity and thermal conductivity were all measured in the temperature range of room temperature to 673 K. The sample synthesized at 2.0 GPa showed the highest power factor of 29.3 μWcm-1K-2 at 373 K. A dimensionless thermoelectric figure of merit (ZT) of 0.51 at 673 K was achieved for n-type In0.4Co4Sb12 prepared at 1.3 GPa, which was significantly enhanced in comparison with pure CoSb3.


This article analyzes the practical problems of the drilling fund—which is becoming an increasingly common method of obtaining financing for the exploration and production of oil and gas. The article discusses whether or not it is necessary to register limited partnership drilling fund formed in the United States under the legislation of Canadian oil and gas jurisdictions, the ability of such limited partnership to carry on business in these jurisdic tions without jeopardizing the limited liability of its limited partners, the number of members that the drilling fund partnerships may have and the name that it may use under the said legislation. The article also considers whether or not drilling fund qualifies under Section 55 of the Canada Oil and Gas Land Regulations.


Epoxy resin is widely used in high voltage apparatus, electrical machines etc due to its excellent mechanical, electrical and chemical properties. Great progress has been made in application on electrical insulation, casting and potting. The epoxy resin containing nano-size and micro-size Al2O3 of various contents are prepared. The purpose of efforts we engaged in is to study the efforts of nano Al2O3, micro Al2O3 and nano-micro Al2O3 on the characteristics of epoxy resin on electrical and thermal properties. The epoxy resin(UVR6105) is used as the base material and Methyl six hydrogen anhydride is used as the curing agent. Various nanocomposites, microcomposites and nano-microcomposites are prepared and fabricated properly through three roller grinding machine. Breakdown strength experiments are done through JNC801 breakdown voltage tester. Nano Al2O3 enhances the electrical characteristics of epoxy resin on breakdown strength while micro Al2O3 lowers it. The thermal properties of thermal conductivity of the epoxy resin are tested through LFA477. The thermal conductivity of epoxy resin is increasing with the filling contents of the Al2O3 while there is a comparatively lower value if nano Al2O3 is added due to its high thermal interface resistance between epoxy resin and Al2O3.


SCALA© (Sampling Campaigns for Aerosols in the Low Atmosphere) is a web-based software system that was developed in a multidisciplinary manner to integrally support the documentation and the management and analysis of atmospheric aerosol data from sampling campaigns. The software development process applied considered the prototyping and the evolutionary approaches. The software product (SCALA©) allows for the comprehensive management of the sampling campaigns' life cycle (management of the profiles and processes involved in the start-up, development and closure of a campaign) and provides support for both intra- and inter-campaigns data analysis. The pilot deployment of SCALA© considers the Spanish Network on Environmental Differential Mobility Analysers (DMAs) (REDMAAS) and the PROACLIM project. This research project involves, among other objectives, the study of temporal and spatial variations of the atmospheric aerosol through a set of microphysical properties (size distribution, optical properties, hygroscopicity, etc.) measured in several locations in Spain. The main conclusions regarding size distribution are presented in this work. These have been have been extracted through SCALA© from the data collected in the REDMAAS 2015 and 2019 intercomparison campaigns and two years (2015 and 2016) of measurements with two Scanning Mobility Particle Sizers (SMPS) at CIEMAT (Madrid, central Spain) and UDC (A Coruña, NW of Spain) sites.


In smaller libraries without a Collection Development Librarian, there is often little time for collection management. At such institutions, librariansmight consider guerrilla collection development: a series of time-saving tactics to get the job done. Although not an ideal approach, it might be a functional solution in the real world.


The microstructure of AZ61 magnesium alloy with the addition of Sm(0~2.0 wt%) was investigated by means of XRD,OM,SEM and TEM.The results show that with the addition of Sm,the spotted high-melting point Al2Sm particals are formed in the alloy.Al2Sm phase can cause the heterogeneous nucleation of α-Mg matrix and refined the microstructure of AZ61 alloy.


This study examined the associations between adverse parenting and adjustment problems in the short and long term, exploring conceptual as well as methodological issues. Using a wide range of indicators of parent-child interaction, reflecting both parental behaviour and maternal expressed emotion (EE), it aimed to investigate the relationships between parenting on the one hand, and conduct problems, and adult selfesteem and depression on the other. The study was based on re-analysis of two sub-groups of the Inner London Cohort, a randomly selected control group, and a random sample of those with high scores on a teacher behaviour questionnaire. Prospective data concerning parentchild interaction and the child's functioning were collected in an interview with the child's mother, and retrospective reports on parenting experiences, as well as information about adult adjustment, were obtained in a follow-up interview with the child when he or she had reached early adulthood. Analysis focusing on the data collected in childhood confirmed a link between certain aspects of parenting and conduct problems, but only when these were reported by the mother. An examination of the reliability and validity of retrospective recall of parenting experiences, using structural equation modelling, revealed that the match between prospective and retrospective reports was unimpressive, and there was some indication that maternal criticality of the child influenced the child's later recall. This analysis also made the estimation of underlying parenting factors possible, and allowed their relationship with adult self-esteem to be investigated. Of these, maternal EE and father's positive behaviour showed a significant association with adult selfesteem in men, whereas the results for the women were inconclusive. Due to the low rate of depression in men, the association between parent-child interaction and adult depression could only be studied in women. In this last set of analyses, adult lifetime depression appeared to be linked to lack of positive interaction with the child's


The electromagnetic field radiated from a magnetic dipole lying on the ground is considered, in the extremely low frequency range (DC to 20 000 Hertz).

Theoretical and experimental data are given on the characteristics of the surface wave (vanishing wave) generated at the air-ground interface, in the case of an homogeneous subsurface.

The case of a subsurface with electrical resistivity varying with depth is considered.

It is shown how the above-mentioned characteristics may be applied in the quantitative investigation of the electrical resistivity of the subsurface as a function of depth, in a method using the measurements on the ground of all the components of the radiated field: horizontal electrical components, vertical and horizontal magnetic components.

RESUME

On considere le champ electromagnetique rayone par un dipole magnetique reposant sur le sol, dans le domaine des frequences extremement basses (du continu a 20 000 Hertz).

On met en evidence theoriquement et experimentalement les caracteres de ľonde de surface (onde evanescente) prenant naissance sur ľinterface air-sol, dans le cas ?un sous-sol homogene.

On envisage le cas ?un sous-sol a resistiviteelectrique variable avec la profondeur.

On montre comment les proprietes precedentes peuvent s'appliquer aľinvestigation quantitative de la resistiviteelectrique du sous-sol en fonction de la profondeur dans une methode qui utilise la mesure a la surface du sol de toutes les composantes du champ rayone: composantes horizontales du champ electrique, composantes horizontales et verticale du champ magnetique.


Relative Hypoxic Stress Induces Anaphylaxis See article p. 2959 New Treatment for a Rare Primary Immunodeficiency See article p. 2979 MDA5 Mediates Antifungal Immunity See article p. 3058 Improving Human IL-10 for Clinical Application See article p. 3191


PROBLEM TO BE SOLVED: To provide a method capable of inexpensively manufacturing an optical filter for display in a high productivity as a whole, and to provide the optical filter for display. SOLUTION: Metal mesh patterns 22 in accordance with a screen size of a display are provided on one surface of a long transparent substrate 21 released and supplied from a roll, the patterns provided at a given interval along the longitudinal direction of the transparent substrate 21. The metal mesh pattern 22 comprises a mesh pattern made of a conductive metal thin film and a plating layer formed thereon by electroless plating and/or electroplating, and an electrode frame 23 made of a metal mesh or a metal thin film is disposed around the metal mesh pattern 22. After a long near-IR ray absorbing film having a near-IR ray absorbent layer released and supplied from a roll is laminated with the substrate surface where the metal mesh patterns 22 are not disposed, a functional layer is layered on the metal mesh pattern 22 in the electrode frame 23. COPYRIGHT: (C)2009,JPO&INPIT


The FDA has requested that manufacturers of asthma and rhinitis drugs with leukotriene inhibitors as the active ingredient include a psychiatric warning of mood and behavior changes among some users.


The room-temperature growth of Cu on the polar (0001)-Zn and (0001)-O surfaces of zinc oxide has been studied with scanning tunneling microscopy (STM). Copper grows on the (0001)-Zn surface as three-dimensional clusters even at low coverages (0.05−0.25 monolayers (ML)); two-dimensional (2D) islands are only observed at very low coverages (0.001−0.05 ML). The average size of the 3D clusters increases with coverage, and their density increases slowly. Surface roughness and sputter damage change the growth mode to more 2D-like. The Cu clusters are well-separated and exhibit a well-defined hexagonal shape. Equilibrium crystal shape analysis yields an apparent work of adhesion of 3.4 ± 0.1 J/m2 for the largest clusters. On the (0001)-O surface, formation of two-dimensional Cu clusters was observed at coverages of less than 0.1 ML.


The surface morphology and interface structure of ultra-thin amorphous silicon (a-Si:H) films deposited on glass, Si, SnO/sub 2/ and graphite substrates were investigated by in-situ X-ray photoelectron spectroscopy (XPS) and ex-situ atomic force microscopy (AFM). The growth mode varied between two dimensional homogeneous coverage and three dimensional island formation depending on the substrate material, deposition temperature and reactive plasma treatment of the substrate. The phenomena are interpreted by taking into account the surface diffusion of adsorbed precursors and the wettability of a-Si:H with the substrate surface. Chemical modification of substrate surface is shown to exhibit a remarkable effect on the growth mode of a-Si:H.


vocational education, particularly vocational teachers. The demands of vocational teachers in the digital era to be expected to be able to develop learning skills by using concepts, ideas, and thoughts in solving problems through digital technology, so that teachers are able to integrate digital technology in the learning process. This study aims to analyze the level of ICT skills of vocational teachers in West Java. The data of this study were collected using quantitative methods, questionnaires were given to 185 vocational teachers who taught subjects in both public and private vocational schools. Questionnaire items related to the knowledge of teacher ICT skills is based on demographic factors. Data analysis used SPSS V. 23 using independent T-Test and one way ANOVA. The findings of ICT abilities based on demographic factors (age, gender, years of service, academic qualifications and teacher certification) are valued at P>.05. This means that all ICT skills of teachers based on their demographic factors do not have a significant difference. However with further analysis, the average ICT ability of vocational teachers diverse based on age, gender, years of service, academic qualifications and teacher certification. Another finding is that the ability of ICTs to use Microsoft Power point is still weak compared to the ability to use computers, Microsoft Word, Excel and the internet. So training is required to improve the ability of ICT vocational teachers in an effort to integrate ICT in the learning process in the classroom


(By T .... A"."elaled P .... ) WtA8HINGTON, June 8 The airship 1.os Angeles was directed by Secretary Wllbqr tocl..~y to rc· Rume Its flight to Mlnnllsota as soon 8S necessary engine repul ra 111'0 made. It Is expected the dlrlgllile lhat turned back after reaching Cleveland yeslerday becauso of en· glne trOUble will leave Lake· hurst, N. J., In Its second attompt In about lWo days, if weather con· dllions are fnvorable. The secre· lary a lso announcod the request ot lhe Norwegian Aroal cl ub that the United States navy Bend the dlr· Iglble LOB Angeles 01' Shenandoah In search of tbe Amundsen expedl. tlon hlld been refused.


The research was conducted to investigate the correlation between the number of livestock ownership and application level of forage technology physically in dairy farmers group. The aim of this research is to determine the number of livestock ownership and the application level of forage technology physically as well as to analyze the correlation between the number of livestock ownership and application level of forage technology physically. The research was conducted for 1 week on 26 February – 3 March 2016 take place in Desa Mekarjaya, Kecamatan Cikajang, Kabupaten Garut. This research make use of survey method with descriptive statistic analysis and Rank Spearmann correlation analysis on 30 farmers respondence who incorporated in Pamegatan Group. The result of research showed 1) the number of livestock ownership on farm in Pamegatan group generally was belong to low scale category specifically 1 – 2 head of dairy, 2) the application level of forage technology physically on farm in Pamegatan group belong to medium category and, 3) the number of livestock ownership have a positive correlation on application level of forage technology physically in dairy farmers group by means of Rs 0,487 with a closeness level of fairly closely. Keyword : The number of livestock ownership, forage technology, dairy farmers


The buried pipelines and metallic structures in subway systems are subjected to electrochemical corrosion under the stray current interference. The corrosion current density determines the degree and the speed of stray current corrosion. A method combining electrochemical experiment with the machine learning algorithm was utilized in this research to study the corrosion current density under the coupling action of stray current and chloride ion. In this study, a quantum particle swarm optimization-neural network (QPSO-NN) model was built up to predict the corrosion current density in the process of stray current corrosion. The QPSO algorithm was employed to optimize the updating process of weights and biases in the artificial neural network (ANN). The results show that the accuracy of the proposed QPSO-NN model is better than the model based on backpropagation neural network (BPNN) and particle swarm optimization-neural network (PSO-NN). The accuracy distribution of the QPSO-NN model is more stable than that of the BPNN model and the PSO-NN model. The presented model can be used for the prediction of corrosion current density and provides the possibility to monitor the stray current corrosion in subway system through an intelligent learning algorithm.


This Chapter is the last of the three data analysis chapters in this study. Analysis in Chapter Five established a high demand for higher education in Botswana, which could not be met by face-to-face mode of provision alone. ODL had been identified as one of the strategies to be adopted to increase enrolments at this level. In Chapter Six, the assessment confirmed a slow growth of ODL in the UB dual mode system which resulted in its insignificant contribution towards increased participation in higher education. Chapter Six also considered some of the external as well as internal factors perceived to be contributory to the low enrolments through ODL into UB programmes. Chapter Seven assessed the level of acceptance and value for ODL by the UB community. This last section of the analysis process was more concerned with establishing the perceptions of the UB community towards ODL and how these perceptions might be impacting on its growth. Assessment in this Chapter also looked at how the implementation of the distance education mainstreaming policy and the learning and teaching policy enhanced the acceptance and value of the ODL delivery mode by the UB community.


Background: Centrosomal microtubule nucleation is important in the formation of the microtubule cytoskeleton. Results: An integrin mutant that suppresses MEK/ERK signaling substantially reduces microtubule nucleation. Expression of activated RAF-1 restores nucleation inhibited by the mutant integrin. Conclusion: Integrins promote microtubule nucleation by regulating MEK/ERK signaling. Significance: Environmental cues provided by cell-matrix adhesion contribute to the regulation of the microtubule nucleating activity of the centrosome. Microtubule nucleation is an essential step in the formation of the microtubule cytoskeleton. We recently showed that androgen and Src promote microtubule nucleation and γ-tubulin accumulation at the centrosome. Here, we explore the mechanisms by which androgen and Src regulate these processes and ask whether integrins play a role. We perturb integrin function by a tyrosine-to-alanine substitution in membrane-proximal NPIY motif in the integrin β1 tail and show that this mutant substantially decreases microtubule nucleation and γ-tubulin accumulation at the centrosome. Because androgen stimulation promotes the interaction of the androgen receptor with Src, resulting in PI3K/AKT and MEK/ERK signaling, we asked whether these pathways are inhibited by the mutant integrin and whether they regulate microtubule nucleation. Our results indicate that the formation of the androgen receptor-Src complex and the activation of downstream pathways are significantly suppressed when cells are adhered by the mutant integrin. Inhibitor studies indicate that microtubule nucleation requires MEK/ERK but not PI3K/AKT signaling. Importantly, the expression of activated RAF-1 is sufficient to rescue microtubule nucleation inhibited by the mutant integrin by promoting the centrosomal accumulation of γ-tubulin. Our data define a novel paradigm of integrin signaling, where integrins regulate microtubule nucleation by promoting the formation of androgen receptor-Src signaling complexes to activate the MEK/ERK signaling pathway.


Translation and writing possess similar approaches and features. This study addressed the relationship between translation and writing in relation to gender differences in translation quality of expressive and informative texts and writing style (expressive vs. informative). The sample of the study included 150 (75 female & 75 male) undergraduate senior students, majoring in English translation randomly selected from 10 universities. They took a translation task of two English paragraphs (expressive & informative) to be translated into Persian. They were, then, requested to write a paragraph in Persian. The quality of translation texts and writing style were assessed by three translation and three linguistics experts, respectively. The data were analyzed separately for each group by employing the t-test and the two-way ANOVA. The results indicated a statistically significant difference between the translation quality of the expressive text and the writing style with regard to the male subjects. The two-way ANOVA results, also, showed a significant relationship between the writing style and the translation quality of the expressive text. No significant relationship, however, was demonstrated between other variables of interest.


Abstract: Two methods for controlling servomotors with pulse encoders are presented for improving the movement of a carry hospital robot (CHR) along a desired line. Some simulation studies have been executed for the design of a PI controller or optimal regulator for the control of the DC servomotor. By applying the simulation results, we actually design a PI controller in an analogue circuit and experimentally compare the results of the PI control with those of a PLL (Phase Locked Loop) control. It is then clarified that the latter approach is effective in improving the accuracy of the CHR.


Abstract Background: Impaired autonomic function (AF) can result in adverse cardiovascular events during the perioperative period. Literature suggests that patients with intracranial space-occupying lesions experience impaired AF depending on the site of tumour and associated raised intracranial pressure (ICP). The complex interaction between general anaesthetics, AF and intracranial tumours with raised ICP has not been extensively studied. Objective: This study was aimed at evaluating the cardiac AF (in terms of heart rate variability [HRV]) in patients undergoing surgery for supratentorial tumours, at baseline and at different propofol effect site concentrations (Ce) during anaesthetic induction and the results were compared with patients undergoing non-cranial surgeries. Materials and Methods: In this prospective observational study, consecutive adult patients undergoing surgeries for supratentorial tumour (study group) and brachial plexus injury (control group) were recruited. Electrocardiogram was recorded for 5 min at three time points – before propofol induction, at propofol Ce 2 μg/ml and at Ce 4 μg/ml. Results: Forty-five patients were recruited, 24 in study group and 21 in control group. In spite of similar baseline heart rate and blood pressure, low frequency (LF), high frequency (HF) and total power were significantly higher in control group. Baseline LF/HF, though higher in patients with intracranial tumour (craniotomy: 2.2 ± 2.2, control: 1.2 ± 1.1), was not significantly different between the two groups (P = 0.197). HRV variables in both the groups changed the same way in response to the increasing propofol Ce. Conclusion: HRV measurements were significantly different at baseline between the two groups. Following propofol administration, haemodynamic changes and HRV changes were similar in both the groups and also between the two groups.


In a camera phone has a function of imaging an object, capturing an image of the imaging object through when performing a camera mode, the lens (Capture) and, for the image, as the lens is slid in the longitudinal direction in which the image pick-up on the lens a lens for adjusting the focus module unit, and a lens driving unit that controls the lens module portion focusing operation, and when the voltage value of the power supplied in order to move the lens group exceeds the set voltage value outputs an interrupt signal, the control a control operation of the lens driving unit, and when the interrupt signal output from the lens drive type is characterized in that it comprises a control unit for controlling the lens driving unit configured to add the lens module stops the focusing operation. Therefore, the present invention is by providing a camera phone with a automatic focusing function enables users to focus on to improve the blurring problem when taking the objects using a camera phone. In addition, there is an effect that the user can use the camera phone with auto focus feature to conveniently take pictures.


OBJECTIVE
We aimed to investigate whether dietary patterns were associated with the risk of type 2 diabetes (T2DM) or pre-diabetes in adults of rural area in Henan.

DESIGN
Cross-sectional study. Principal component analysis was used to identify dietary patterns, while multivariate logistic regression analysis and restricted cubic spline regression models were used to analyze the association between dietary patterns and both pre-diabetes and T2DM.

SETTING
Rural area of Henan province, China.

PARTICIPANTS
A total of 38779 adults aged 18-79 years were recruited from the Henan rural cohort study as the subjects.

RESULTS
The prevalence of pre-diabetes and T2DM in rural Henan was 6.8% and 9.4%, respectively. A total of three dietary patterns were assessed in the present study. Dietary patternⅠwith a high intake of red meat and white meat; dietary pattern Ⅱwith a high intake of grains, nuts, milk and eggs; and dietary pattern Ⅲ with a high intake of vegetables, staple food and fruits. The highest quintile (Q5) of pattern Ⅲ could reduce 32.7% risk of pre-diabetes. The Q5 of patternⅡshowed a 15.5% decreased risk of T2DM, in an U-shaped dose-response manner; meanwhile, the Q5 of pattern Ⅲ were significantly associated with reduced risks of T2DM (OR: 0.582, 95% CI: 0.497-0.682).

CONCLUSIONS
Pattern Ⅲ is beneficial for reducing risk of pre-diabetes or T2DM. Though a higher consumption of "grains-nuts-egg" may associate with a reduced risk of T2DM, excessive intakes should be avoided. This study may provide a reference for the prevention of diabetes on dietary precautions.


Author(s) Title Number of Pages Date Heikki Marno Implantation Forces and Anatomical Fit of Medtentia Annuloplasty Ring in Porcine Hearts 43 pages + 2 appendices 30 May 2013 Degree Bachelor of science Degree Programme Health informatics Specialisation option N/A Instructor(s) Jani Virtanen, D.Sc.(tech), CTO, Medtentia International Ltd Oy Mikael Soini, D.Sc. (tech), Principal lecturer, Metropolia Medtentia annuloplasty ring (MAR) is an implant for mitral valve repair using a helix ring concept developed by Medtentia International ltd. This helix ring implant takes on mitral annuloplasty with a new perspective as it utilizes the anatomy of the valve and is easier to implant compared to regular annuloplasty rings. As the implantation procedure takes less time and can be performed with minimal invasive surgery, it brings a potential treatment form for patients for whom surgery is considered too risky today. This bachelor's thesis was a part of Medtentia's research and development project to gain knowledge about the forces linked with the implantation of MAR. The initial problem had to with knowing when an expanded MAR should be implanted instead of the regular MAR. The measurement data was gathered by implanting various MARs and testers into porcine hearts while being attached to a digital force meter. The hearts used in the measurements were from pigs weighing from 180 to 250 kg. The measurements were performed at the Hospital district of Helsinki and Uusimaa in Meilahti research and development unit during the time period of 11/2012 and 1/2013. There were a total of 41 recorded measurements done on 6 porcine hearts. The findings in this research are used in the ongoing development of MAR, its accessories and their implantation procedures. These include giving recommendations on the limit of the implanted mitral valves width when switching to an expanded option of MAR. Implantation procedure trouble spots and possible new solutions were added to the summary as well. The most concrete improvement was the calibration of the helix tester to simulate regular MAR better. An implantation slide that reduced implantation friction led to patenting.


An improvement of selectivity for electrochemical detection of dopamine (DA) with differential pulse voltammetry is achieved by covalently modifying a glassy carbon electrode (GCE) with O-carboxymethylchitosan (OCMCS). The amphiphilic chitosan provides electrostatic accumulation of DA onto the electrode surface. In a phosphate buffer solution (pH 6.0), a pair of well-defined reversible redox waves of DA was observed at the OCMCS/GCE with a ΔEp of 52 mV. The anodic peak current obtained from the differential pulse voltammetry of dopamine was linearly dependent on its concentration in the range of 6.0 × 10-8 to 7.0 × 10-6 M, with a correlation coefficient of 0.998. The detection limit (S/N = 3) was found to be 1.5 × 10-9 M. The modified electrode had been applied to the determination of DA in human serum samples with satisfactory results.


This study aims to contribute to the under-researched area of LGBTQI activism in the 'Global South' by performing a case study of LGBTQI activism in India, a country that provides an intriguing set ...


The strategy of Rural Revitalization emphasizes the priority development of rural education. At present, the improvement of the consolidation rate of compulsory education in China has entered the critical stage, and the problem of rural junior high school students dropping out of school has become the main obstacle to the improvement of the consolidation rate of compulsory education, which urgently needs to explore the way of governance under the background of the strategy of Rural Revitalization. Based on the theoretical model of human development ecology, this paper takes the micro individual system and macro social system which interact with dropouts as the analysis framework. On this basis, it analyzes the main influence mechanism of dropout behavior of rural junior high school students under the theory of social interaction. Then combined with the actual situation of our country, it discusses the governance path of rural junior high school students dropping out of school under the background of Rural Revitalization.


Over the years, a large number of psychophysiological deficits have been demonstrated in schizophrenia.The greatest challenge is to progress beyond studies of phenomenology to investigations of etiology. The ability to combine psychophysiology with neuroimaging, along with the development of animal


Reported are the characteristics of 850 nm vertical cavity surface emitting lasers (VCSELs) with integrated linear diffractive gratings emitting a dual-beam output with negligible increase in threshold and excellent zero-order cancellation. Power emitted into the first orders is greater than 80%. The use of a dual-beam VCSEL for measurement of surface topography using interferometry is demonstrated.


Abstract A challenge involving interpreting the numbers ζ(k) – 1 as probabilities, with an eye to aesthetics, is formalized and an interpretation offered.


Objective To evaluate the clinical results of the giant cell tumors of long bones treated with different surgical procedures.Methods 48 patients with giant cell tumors in extreme ities who were treated with operation from May 1998 to May 2006 were reviewed.There were 28malesand 20 females with the mean age of 31 years old(16~59 years).The anatomic site for the lesions were the distal femur(19 cases),proximal tibia(18 cases),proximal femur(5 cases),proximal humerus(5 cases),distal humerus(1 case).Using Campanacci staging system:7 cases were classified as gradeⅠ,30 as grade Ⅱ,11 as grade Ⅲ.17 cases had been performed tumor curettage with bone graft or cementation,19 cases received internal fixation with bone graft curettage,enblock excision and reconstruction by endoprostheses were done for 12 cases.Results The mean follow-up time was 6.8(3~11)years.the recurrence rate was 4 cases(11.1%) in group of cases with tumor curettage,and 1 case(8.3%) with joint replacement.Using Enneking functional evaluation:excellent in 25 cases,good in 12 cases,six cases can be,and poor in 5 cases,the overall satisfaction rate of 89.6%.Conclusion Curetting and bone graft are still the elemental surgical therapies to treat the giant cell tumor of bone.Adjunctive treatment such as high speed grinding and Distilled water immersion could reduce recurrence rate.And has a good limb function;Enblock excision is indicated in patients who were classified as Campanacci Ⅲ.The recurrence rate is low in this group,however there are many complications.


Ridgelet transform is a new kind of multiscale analysis technique after wavelet transform.It is more effective than wavelet transform.The fundamental of a method of ridgelet transform is introduced,and its realization arithmetic is described.Given the method of experimentation and made a conclusion based on the application of the ridgelet transform in motor rotor bars failure diagnosis.


This article analyzes how liberal, American-curriculum universities and neoliberal entrepreneurship centers play a role in shaping the religious subjectivities of millennial Muslim women in the United Arab Emirates (UAE). It is grounded in 2 years of fieldwork and interviews conducted with middle-class, migrant Muslim women living in the UAE, a highly cosmopolitan urban setting shaped deeply by processes of globalization. Examining how 'global forms' materialize in local contexts, the article scrutinizes how the 'assemblages' emerging in educational and entrepreneurial contexts play a vital role in shaping women's practices and sensibilities, conceptualizations of God, and relationships to others. Tracing one woman's intellectual and religious trajectory through her self-narrative, the article intervenes in debates on the global reach and resonance of American educational 'imperialism'; the entanglement of religious and entrepreneurial subjectivity; and the contemporary forms of Islamic religiosity in the Middle East.


This paper considers full data exchange for massive uncoordinated multiway relay networks (mu-mRN) applying coded random access for flexible topology changes and capable of serving massive number of users. We aim to maximize the normalized throughput of the mu-mRN using the multiuser detection (MUD) technique with MUD capability of K > 1. Specifically, our goal is multiple times improvement, i.e., ten times improvement, from the maximum normalized throughput of the mu-mRN applying slotted ALOHA (SA). First, we present a network capacity bound of the mu-mRN with general K. Then, we optimize many degree distributions for the MUD-based mu-mRN. However, as K increases, the distributions are no longer optimal to achieve the network capacity bound. We propose doubly irregular coded SA (dir-CSA) to solve the problem. Asymptotically, the mu-mRN applying dir-CSA with K = 4 can achieve the ten times throughput improvement. However, for finite number of time slots, we propose to exploit side information (SI) from neighboring users to improve the normalized throughput of the mu-mRN. The results show that the mu-mRN applying dir-CSA with SI and having optimal physical encoding can achieve ten times throughput improvement, compared with the conventional SA scheme.


Helicopter-borne sensors have been used since the early 1990s to monitor ice properties in support of winter marine transportation along the East Coast of Canada. The observations are used directly in ice chart production and indirectly in the validation of ice hazard identification algorithms using satellite imagery, the main source of data for ice chart production. Called the VideoGPS Sensor System, this system includes a laser altimeter, digital image capture and a GPS receiver for positioning. This system is usually operated concurrently with an electromagnetic-based ice thickness sensor. A commercial off the-shelf ground penetrating radar (GPR) system has recently been integrated into the VideoGPS system. The VideoGPS system has a laser altimeter to measure flying height and ice roughness. Digital images are collected with enough overlap so they can be mosaicked to provide a two-dimensional image of the ice surface along the helicopter's flight path and complement the detailed one-dimensional laser roughness profile. A Matlab-based data processing environment with a graphical user interface has been developed to handle the data integration and the display of the results. The ground penetrating radar (GPR) system has been added to the VideoGPS system for snow thickness measurements. As snow and ice thickness measurements using airborne GPR have been used for over 30 years, the evaluation of GPR performance was to ensure the overall system packaging performed properly, not to evaluate whether or not GPR can measure snow and ice thickness. References going back thirty years are provided. Due to limited snow cover during the field trials of 2007 and 2008 in Prince Edward Island, Canada, the integrated system has been evaluated with data collected over a frozen fresh water lake. GPR data results are shown which include the laser altimeter flying height for evaluation purposes. GPR data were processed for freshwater ice thickness for several parallel flight lines and these are shown as a colour-coded result on a digital image mosaic of the flight path. In addition, recent snow thickness measurement results from April 2008 in the eastern Canadian Beaufort Sea are presented.


THE object of this investigation is to study briefly the relation deep X-ray therapy has to the cure of carcinoma of the breast and to the alleviation of symptoms and prolongation of life of patients suffering from it. In our series of 148 cases we have complete records in 109 instances. These records include a carefully taken history; in most instances diagrams of the location of the tumor in the breast; roentgenograms of the chest, spine, and pelvis before and in many cases after operation; the results of study of pathologic specimens after operation, including the axillary glands involved (these we speak of as base, mid-, and apex glands). The records also include a statement as to duration of freedom from symptoms after operation, and, in those patients who have returned with metastasis, roentgenograms of the entire skeleton. In our cases, with few exceptions, we have record of the ultimate result. We began the treatment of cancer of the breast with deep therapy in December, 1922, —about six years ago...


: Public space in central city areas is a limited resource bearing the responsibilities of creating a city image and satisfying citizens' mental demands. With the rapid socioeconomic development and consequential stress becoming a common problem in major cities, the role of urban public space and its management have attracted more and more attention of both governments and scholars. This paper investigates the changing patterns of public space management of the Lujiazui Financial and Trade Zone, regarded as the symbol and financial center of Shanghai, from its establishment to its current status. Despite the government playing a leading role since the early stages of the reform, a series of emerging problems, such as traffic inconvenience and lack of cultural atmosphere, have started to impede the further development of Lujiazui CBD in recent years. In order to construct Shanghai as an international financial center, an improved mechanism of public space management needs to be created to solve these problems and make the city more attractive and comfortable to people.


We are presenting the results of our ongoing efforts to develop a new type of focal plane detector for the 10 to 100 keV band with an energy resolution of 0.1 %. The device will measure energy and position by using microwave kinetic inductance detectors (MKIDs) to sense athermal phonons created by photon absorption in a dielectric substrate. We have fabricated a proof-of-concept detector of size 2 cm × 2 cm × 1 mm on silicon, which has demonstrated a baseline energy resolution of = 0.38 keV and = 0.55 keV at 30 keV.


Digital teaching competences emerge in the context of educational activity as a mechanism of development with high possibilities of success and feasibility. For teachers, the appropriate use of information and communication technologies (ICT) means the possibility of more agile, efficient, and effective communication with students. In this context, ICT are a fundamental means of production, dissemination, and assessment to meet educational needs and build meaningful learning. This study focuses on the creation of a diagnosis of digital teaching competences and the development of a prospective that helps the participants achieve better application of ICT in the context of building learning. This research identifies and describes digital competences and then develops subcompetences for each of them, which allows more significant pathways of action to be plotted out regarding the incorporation of ICT into the teaching-learning process. The instrument developed was applied to a group of teachers involved in the Bachelor's Degree Program in Digital Arts at the Universidad de Guanajuato, Mexico. The analysis of the data enabled the development of a plan that would encourage better practices among the teachers on this program.


Currently China's economic development is in an important period of strategic opportunities.The Third Plenary Session of the 18 th Central Committee of the CPC have made the decision "making the market plays a decisive role in the allocation of resources",but we must deal with the relationship between the government and the market in the process of implementation of innovation-driven development strategy. We need to ensure that the government has an irreplaceable position and role in technological innovation and make the government play an important role in improving and strengthening the technological innovation ability of Chinese enterprises. In particular,we have an obligation to pay attention to explore how government policies and regulations for the market mechanisms to guide social resources to invest in technological innovation under the condition of marketing economy.


Corrosion Characteristics of EB–PVD Ti/TiN Multi–layer Film Coated Sm–Co and Fe–Nd–B Magnets Han–Cheol Choe1, Yeong–Mu Ko2 and Keum–Yeon Hwang3 1Department of Metallugical Engineering & Industry–Academy–Government Collaboration Research Institute, Kwang Yang College, Chonnam 545–800, Korea 2Department of Dental Materials, College of Dentistry, Chosun University, Kwang Ju 501–759, Korea 3Kwang Yang Research Laboratory, Technical Research Laboratories, POSCO, Kwang Yang, Chonnam 545–090, Korea


In the context of economic globalization, there has been considerable academic interest on the understanding of location behavior of FDI firms. Generally while studies on FDI firm location focus mainly at the national and regional levels, those of the intra-urban level are limited, especially for developing countries. In developing countries, intensive studies have been carried out on the spatial impacts of foreign capital on the country city system or the regional determinants in the location choice of the foreign capital (Deichmann et al. 2003; Wei et al., 1999; Chien-Hsun, 1996). However, studies on the impacts of the foreign investments in the cities of the developing countries are limited (Wei et al. 2006; Wu and Radbone, 2005; Wu, 2000). The same situation is valid for the studies conducted in Turkey. However, studies on the spatial models at the intra-urban level are limited. The priorities in the location choice preferences of the FDI firms working in both industrial and service sectors in the Istanbul metropolitan area have been set forth by a study conducted by Berkoz (2005). Foreign investment requires the market conditions of the area on which it would invest to be feasible for non-risky business and demands the conditions concerning the spatial quality of the area (such as the quality infrastructure, easy access, transportation-communication systems and the quality of the building and environment) to be of high standards as they are the conditions which reflect the power and prestige of the firm (Berkoz, 2005). For this reason, it is very important to know the characteristics and spatial distribution of FDI firms in Turkey. FDIs in Turkey have been concentrated in the biggest city, Istanbul, which attracts the highest level of foreign investment in Turkey. In this study, locational determinants of foreign investment firms in Istanbul have been analyzed by using the logistic regression model.


MODEMIC is a joint INRA-INRIA team, which research activities focus on model-ling and simulating of natural or reconstituted microbial ecosystems, over several time and space scales, as well as various diversity levels. The main object ives of the project are : - a better understanding of microbial ecology, especially its functions (degradation, fermenta- tion, sequestration...), its biodiversity and its role in preserving the environment (quality of water resources, soil fertility...) - new decision-making tools for managing and improving bioprocesses (decontamination, green chemistry...)


This article examines new designs of lorry trailers available in the UK. There is a growing interest in postless curtainsiders and double-deck, multi-temperature reefers. Specifications for vehicles are dependent on the customer's operations and the potential for backloading must be considered. Multiple deck trailer units are available with fixed, folding or ratchet decks; pivoting or rotating sections; and table decks. These trailers are much heavier but one model of lifting deck trailer has been designed to reduce weight by using aluminium honeycomb sheeting for the body shell. One recent design incorporates solar panels in its top section which recharge the trailer batteries. New weight-saving designs in the liquid freight market involve size reductions in brake discs, frames, air tanks and sumps, with aluminium again featuring in the design.


PURPOSE
To report a case of choroidal neovascularization (CNV) associated with Multiple Evanescent White Dot Syndrome (MEWDS) in a child.

STUDY DESIGN
Case report.

RESULTS
A 13-year-old child visited us with a month-long history of blurred vision in his right eye. His right fundus showed several subretinal white dots and an atrophic macular lesion corresponding to a CNV. Angiography and optical coherence tomography (OCT) were consistent with the diagnosis of MEWDS. The patient's condition poorly improved after an intravitreal injection of anti-vascular endothelial growth factor (anti VEGF) in his right eye.

CONCLUSIONS
We reported the case of CNV associated with MEWDS like reaction. The hypothesis of a triggered-MEWDS was highly suspected but no cause was found, which is often the case in paediatric inflammatory eye disorders. Long-term follow-up is needed to judge the evolution.


Calibration of models can be described as a process of estimating (or defining) model parameters (or their probability distributions) that allow the model to closely match the observed behaviour of the real system it represents. From the general literature review, it can be found that there are four concepts of models calibration. The first and the most commonly used one is the trial-and-error method, which is the manual iterative process of selecting an optimal parameter set until such set that satisfies some pre-defined criteria has been obtained. Due to the limitations in trial-and-error approach, research into the automatic calibration procedures has led to the use of different automatic parameter optimisation approaches. In this respect, the global optimisation has evolved as a second approach to identify an optimal parameter set that can be identified among many parameters sets fulfilling the pre-defined criteria. The third approach differs from the first two approaches on the basis that an optimal parameters set cannot be identified, but have to be generated by sampling; this leads to the acceptance of several models whose outputs have to be combined. A typical representative of this approach is the Generalised Likelihood Uncertainty Estimation (GLUE) methodology. The fourth approach implies that no calibration is needed, instead it suggests using a 'code of good practice' or the parameters from literature/industry experience. This paper discusses these four approaches and their relevance in urban drainage modelling.


In this work we present a laser cavity with a spatial light modulator (SLM), which allows for arbitrary phase and amplitude manipulation. In comparison to previous setups, it allows the manipulation of spectral components inside the laser cavity without the introduction of spatial chirp. An electrically driven ultrafast semiconductor laser system is used for proper alignment of the laser cavity. We were able to demonstrate that the gain of the laser supports mode-locking operation over a spectral range greater than 12 nm with a central wavelength of 850 nm. This bandwidth has the potential to generate sub 150 fs pulses.


The Powder Data File (PDF) contains far fewer organic entries than inorganic ones despite the existence of many more organic compounds. The ready availability of many of the missing organic substances affords their potential inclusion via quality experimental patterns. Considerable expansion of the organic portion of the PDF is also available via computation from the extensive published single crystal literature. Careful comparison of calculated and experimental patterns can be quite useful in resolving problems encounter in patterns from each source and in more fully characterizing ''real-life'' materials. Examples of this interplay are presented, featuring, particularly, explosive compounds, an especially sparsely populated portion of the PDF.


It follows from the results of I. N. Baker ([1], [2]) that ifK is an algebraically closed field of zero characteristic and f is a non-linear polynomial over K then f has in K cycles of all lengths with at most one exception. Moreover, the exceptional case may occur only when f is linearly conjugate to the polynomial X−X. (Two polynomials f and g are called linearly conjugate if f(aX + b) = ag(X)+ b for some a, b ∈ K, a 6= 0.) In this exceptional case there are no cycles of length 2. For n = 1, 2, . . . denote by fn the nth iterate of f and let Z(n) = {m : m |n, m < n}. Put also N = {1, 2, . . .}, and let CYCL(f) denote the set of all lengths of cycles for f ∈ K[X]. Thus in algebraically closed fields of zero characteristic one has for non-linear polynomials f either CYCL(f) = N or CYCL(f) = N \ {2}. Here we shall consider the same question in algebraically closed fields of prime characteristic. It has been established by G. Chassé [3] that in this case CYCL(f) is infinite for all non-linear f . We shall make this result more precise and describe this set up to finitely many elements. Since for linearly conjugate polynomials the sets of their cycle lengths coincide it is sufficient to consider f monic and vanishing at 0.


The university funding for tertiary training in psychology has received a welcome boost in the most recent Federal budget. But a significant funding shortfall still remains which needs to be filled, keeping in mind the high costs incurred in training a clinical psychologist at Masters level.


In allusion to the lack of practice,schematism and multiplicity for the existing logistic talent training model,this paper propose the simulation-based training model for high-level logistics talent,and take the "beer game" as example,describes the importance of basic theory guided learning,appropriate simulation software choosing,simulation data and case bases building and the playing training methods.


The popularity of distributed test systems is growing for a number of reasons, which include the distribution of processing among multiple intelligent nodes in order to increase computing power and I/O bandwidth and geographic constraints that prohibit all of the components of a system from residing in a single location. This paper will examine the features of the PXI platform that enable the architecting of distributed test systems. These features include software frameworks that easily interface with both local and distributed hardware, integration resources for PXI systems with a diversity of instruments and hybrid test systems, and hardware synchronization resources that enable distributed synchronization down to the sub- nanosecond level by extending the PXI backplane across multiple distributed PXI systems or synchronization over significant distances with technologies such as GPS. This paper will also examine distributed system design techniques for communication and data transfer between intelligent nodes and discuss dedicated deterministic communication for advanced distributed PXI test systems.


Objectives. Because of their recent adoption of a Westernized lifestyle, an increased risk of developing hypertension (HTN) is suspected among Inuit populations. This study aimed to assess the exact prevalence of HTN in Nunavik Inuit and to examine its association with other major risk factors of cardiovascular disease. Study design. A cross-sectional population-based study. Methods. We analysed biological and anthropometric data and the medical history of 832 Inuit. Results. The overall prevalence of HTN (≥140/90 mmHg or the use of medication) was 19% with no gender difference. Obesity (body mass index [BMI] ≥30 kg/m2) was the highest prevalent cardiovascular risk factor (23%), and was significantly associated with HTN (OR for BMI&25 kg/m2 vs. BMI 30–34 kg/m2: 7.9 [3.5–17.9]; OR for BMI&25 kg/m2 vs. BMI ≥35 kg/m2: 14.4 [5.6–36.7]). An increase in odds of prehypertension (preHTN) (130–139/80–89 mmHg) was also observed as the BMI increased (p for trend, p&0.0001). Conclusion. The prevalence of HTN in the Inuit populations has reached values similar to those of their Westernized counterparts. Furthermore, not only HTN but also preHTN states are significantly associated with obesity even after adjusting for confounding variables. These results clearly indicate that HTN is becoming a growing health challenge in Nunavik because of pandemic obesity.


Computer games are applications in form of interactive entertainment or real-time
simulations in 2 dimensional or 3 dimensional graphics. In this era, many genre of
computer games already existed in the market. One problem which arouse in the
development of a game is to achieve the accepted level of realism. Since the launch of
Nvidia's latest product, GeForce-FX series graphic card, use of photo realistic images are
not considered impossible anymore since programming could be instructed directly to the
Graphics Processing Unit (GPU). Still, the judgment between realism and performance
became the focused issue since the displays of realistic 3D environment require detailed
calculations and extensive programming algorithms. This project will reintroduce and
argue the two main realistic lighting method, Phong and Blinn, in real-time applications
with the help of c for Graphic (cg) programming language provided by Nvidia.


A novel drive power supply structure is introduced.A novel resonant-type high frequency AC bus topology is presented and low harmonic disortion current-fed high-frequency AC bus is obtained.The novel structure is of the advantages:high-voltage level isolation,high reliability,excellent extensibility and installation flexibility.And with the novel bus,circuits are simplified,and efficiency and performance are improved.The novel current-fed drive power supply is analyzed in detail.A prototype of 400 W,2.5 A output was built to verify the theoretical analysis.The experiment result shows that high efficiency is achieved(91% maximum efficiency),frequency adjustment range is small within the full load range,current-fed high-frequency AC bus with low harmonic components is obtained.


The imperial examination was always taken seriously by the intellectuals in Ming and Qing dynasties.The novels of the Ming and Qing paid much attention to the imperial examination,especially in the novels during the late Ming dynasty and the early Qing dynasty.The phenomena that the officials directly or indirectly intervened the imperial examinations were reflected in lots of popular novels,such as the relations between teachers and students,contemporaries and friends,and various frauds in the examination hall.The imperial examination phenomena described in the novels of Ming and Qing dynasties reproduced the real scenes against the historical and cultural background at that time.Different narrative perspectives,constituted the different aspect narrative and supplement of historical events,embodied the authors' cognition and construction in that historical situation,also contained the authors' meditation on individual destiny.Thus,social decay and officialdom darkness were one of the main reasons leading to the dead-end of the imperial examination.


With the enormous growth in the Internet and network, data security has become an inevitable concern forany organization. From antecedent security has attracted considerable attention from network researchers. In thisperspective many possible fields of endeavour come to mind with many cryptographic algorithms in a broader way,each is highly worthy and lengthy. As society is moving towards digital information age we necessitate highlystandard algorithms which compute faster when data size is of wide range or scope. On survey, numerous sequentialapproaches carried out by symmetric key algorithms on 128 bits as block size are ascertained to be highly insecurable and resulting at a low speed. As in the course the commodities are immensely parallelized on multi coreprocessors to solve computational problems, in accordance with, propound parallel symmetric key based algorithmsto encrypt/decrypt large data for secure conveyance. The algorithm is aimed to prevail by considering 64 character(512 bits) plain text data, processed 16 characters separately by applying parallelism and finally combine each 16-character cipher data to form 64-character cipher text. The round function employed in the algorithm is verycomplex, on which improves efficacy.


In the previous report, it has been made to evaluate the corrosion rate of steel and other metals in sulfamic acid solution and to search for the corrosion inhibitor for steel in this solution. Resulting from these tests, thiourea derivatives and acetylenic compounds were found to be most effective inhibitors. In this study, we have investigated in detail the inhibiting effect of these inhibitors for iron and other metals in various corrosive environments of sulfamic acid solution. The results were as follows: (1) Ca++ ion has no influence on the corrosion of steel and the effect of inhibitors. (2) An increase in amount of Fe+++ ion results increase in the corrosion rate and decrease in the effect of the inhibitors. (3) Inhibiting effect on cast iron is the nearly same as that on steel, although the corrosion rate of the former is greater than that of the latter. (4) The corrosion of Cu, Al, and Cu-Zn alloy in sulfamic acid in the presence or absence of the inhibitors is smaller than that of steel. (5) The effect of the inhibitors for steel is not lowered by recycled run of the same solution (5 times), but it is slightly lowered by aeration. (6) The synergistic effect of some surface active agents on the inhibiting effect of 1, 3diethyl-thiourea for steel is observed only in inhibitor concentration of below 0.2m mol/1.


My colleagues (G.R. Cole, R.T. Eskew, Jr. and R.E. Kronauer) and I have been studying how luminance information may aid perception of red-green color changes. Related work has been done by Hilz et al, (1974), Boynton et al. (1977) and Nick and Larimer (1983).


Emerging from the repeated crises that Argentina has gone through over the last 35 years and particularly from the hyperinflation of 1989 came the neoliberal program that during the 1990s tied the country to a system of currency convertibility linked to the dollar. These measures opened the market to exportation, privatizing public firms, further expanding foreign debt and turning the country into an exemplary model for orthodox economic thought. Yet in 2001, a popular insurrection led to the model's collapse and created new conditions of governability. The economy was re-oriented and, in spite of opposition coming from several sectors, the country embarked on a new stage of unprecedented growth. While this did not stop Argentina from becoming quite a bad example to follow, within the frame of reference of the global economy, the financial quarantine to which it was subjected preserved it from the worse effects of the 2008 crisis. This article looks at some elements that derive from this situation as well as the strong and weak points of current administrators. We seek attempt to use this opportunity to look at an experience that questions the parameters of the rationality that  prevails in normative economic discourse.


Phomopsis iongicolla Hobbs and P. sojae Lehman are the principal causal organisms of Phomopsis seed decay. This disease can reduce germination and quality of soybean. Production of mycotoxins by Phomopsis spp. has been reported. No commercial cultivars are resistant to Phomopsis seed decay. However, the plant introduction PI-417479 is a source of genetic resistance. When grown under field conditions favorable for infection by Phomopsis spp., PI-417479 was free of seed infection in two tests and had 3% infection in another. In the same environments, the cultivar "Williams 82" had 25 to 59% infection. Inheritance of the trait was determined to provide information for efficient transfer of the resistance to improved cuitivars. Crosses were made between PI-417479 and two susceptible genotypes. Five generations were developed for each cross and tested at two locations. Plots were artificially inoculated to enhance infection. Seeds from plants that showed various degrees of infection in the first season were progenytested. Environment strongly influenced disease incidence, but results indicated that resistance to Phomopsis seed decay is controlled by two complementary dominant nuclear genes. Information developed in these studies will facilitate development of resistant cultivars. ]AOCS 72, 1431-1434 (1995).


Technology entrepreneurship may contribute significantly to economic development and innovation. Little research has investigated the role of the university in technology entrepreneurship among STEM (science, technology, engineering or mathematics) students. More research into the entrepreneurial intentions–behaviour link is needed. This paper aims to identify university-related factors that may contribute to the translation of technopreneurial implementation intentions into actions in a sample of 200 STEM students. The variables university research excellence and perceptions of business development support significantly influence the likelihood of nascent technopreneurial behaviour. This study contributes to a greater understanding of the technopreneurial process and the drivers of technopreneurial behaviour among STEM students. The results of this study may help to enhance nascent entrepreneurship among Bulgarian STEM students.


Cholesterol is essential for maintaining lipid raft integrity and has been regarded as a crucial regulatory factor for amyloidogenesis in Alzheimer's disease (AD). The vast majority of studies on amyloid precursor protein (APP) metabolism and amyloid β‐protein (Aβ) production have focused on neurons. The role of astrocytes remains largely unexplored, despite the presence of activated astrocytes in the brains of most patients with AD and in transgenic models of the disease. The role of cholesterol in Aβ production has been thoroughly studied in neurons and attributed to the participation of lipid rafts in APP metabolism. Thus, in this study, we analyzed the effect of cholesterol loading in astrocytes and analyzed the expression and processing of APP. We found that cholesterol exposure induced astrocyte activation, increased APP content, and enhanced the interaction of APP with BACE‐1. These effects were associated with an enrichment of ganglioside GM1‐cholesterol patches in the astrocyte membrane and with increased ROS production. GLIA 2015;63:2010–2022


In this paper a new fuzzy clustering approach to the color clustering problem has been proposed. To deal with the limitations of the traditional FCM algorithm, we propose a spatial homogeneity-based FCM algorithm. Moreover, the cluster validity index is employed to automatically determine the number of clusters for a given image. We refer to this method as VS-FCM algorithm. The effectiveness of the proposed method is demonstrated through various clustering examples.


This paper analyzes the effects of local ownership requirements on inter-country profit-shifting behavior of the multinational corporation with the help of a vertically-integrated MNC-model in which real variables are decided at the division level. With local ownership requirements, an increase in the reported cost of the intermediate product decreases the MNC's global tax-tariff-foreign-shareholder payment. Still, tax-tariff payments to either home or both (when the tariff-effect dominates the foreign country's profit tax rate-effect) countries increase when the home profit taxd rate is not smaller than the foreign profit tax rate. When it is smaller, these payments increase if, in addition, the product of the foreign profit tax rate and the MNC's share in the foreign subsidiary is smaller than the home profit tax rate.


A genealogical analysis of Crioula horses registered by the Brazilian Association of Crioula Horse Breeders was performed. The state of Rio Grande do Sul is the largest producer of animals with 89.85 percent of registered animals, of which 45.29 percent were males and 54.71 percent females. The inbreeding coefficient was calculated at 0.88 percent and the average relatedness was 0.65 percent in the total population (animals born in Brazil and imported). Inbreeding increased over the generations. An increase was seen in the average genetic conservation index in animals born after the year 1927 (0) until 2010 (8.67 percent). The average generation interval was 10.3 years and the average age of parents when offspring born were 10.5 years, falling in recent years. The effective population size of founders was 95.19 animals, the number of ancestors contributing to this population was 5086 where 56 ancestors explained 50 percent of the genetic diversity of the breed. Inbreeding is under control in the Crioula horse. The increase in registrations reflects the increased interest from farmers in this breed.


ABSTRACT Using a unique quasi-natural event, i.e. gangdom and evil forces (hereafter, GEs) elimination in China, we investigate the relationship between the public governance proxied by GEs elimination and corporate innovation based on the data of Chinese listed firms from 2013 to 2021. The results show that the GEs elimination leads to a 0.39% increase in corporate innovation investment. Quantitatively, the increase is approximately equivalent to 4.42 million yuan for a firm of median innovation investment. Furthermore, we find that the GEs elimination increases corporate innovation through two possible channels: relieving financing constraints and intensifying market competition. In addition, we also reveal that the effects of GEs elimination on corporate innovation are stronger in firms located in a better marketization environment and a stronger Intellectual Property Rights (IPR) protection environment. Our main results pass a series of robustness tests and endogeneity issues.


Pelvicachromis sacrimontis Paulo, 1977 was originally described on the basis of an iconotype in an aquarium journal. Herein, the validity of the name as well as the species status is discussed, an updated diagnosis and description of the species is given, and a neotype and a series of paraneotypes is designated. The species differs from congeners in a combination of coloration features including a broad dark midlateral band, the absence of blue and reddish dots in the caudal fin of males, and the specific coloration of the dorsal fin in females.


The novel 'Lajja' (Shame) was first published in Bengali in Bangladesh in 1993. The English translation appeared a year later. The novel created a lot of controversy - on the one hand, Taslima Nasrin was awarded a prestigious award; on the other hand, Muslim fundamentalists not only banned the novel and burned hundreds of copies, but called for Taslima's death as well -with rewards of up to $1250 for her head. The anger of the mullahs was directed at Taslima for her iconoclastic views on sex, marriage; and religion. What made them furious was her statement, made in Calcutta, that the shariat laws must be revised. What is unpardonable is that a person - a woman too - should speak her mind! Even a liberal minded politician was quoted as saying: 'Championing freedom of speech at the expense of faith can only provide a fillip to extremist trends.'


Evaluation of nuclear power development policies requires the ability to forecast the economic and resource impacts attributable to a given policy. A computer simulation has been used in several recent evaluations of alternate nuclear power growth scenarios for the U.S. By using a discrete event modeling approach, a flexible tool has been developed that can simulate most planned reactor systems in terms of their overall economics and their impacts upon fuel cycle industries.


We have studied the static surface roughness of 50-μm-thick copper electrodeposits on length scales between 5 and 10 4 nm using scanning tunneling and atomic force microscopy. The surface roughness depends strongly on the concentration of organic additives in the plating solution. Both the surface width and poquer spectra scale as a power of the system size. Self-affine surfaces became more fractal-like with decreased additives. The scaling exponent of the self-affine surface (1/2) is slightly larger than the simulation results for local growth models


ObjectiveTo investigate the effect of scalp point penetration combined with rehabilitation training on content of endothelin (ET) and calcitonin gene-related peptide (CGRP) in plasma of patients with acute cerebral hemorrage (ACH).Methods90 ACH patients were randomly divided into the scalp point penetration combined with rehabilitation group (group A), the rehabilitation group (group B) and control group (group C) with 30 cases in each group. The radioimmunoassay was adopted to determinate the content of ET and CGRP in plasma of patients.ResultsAfter treatment, contents of ET and CGRP of all patients were decreased significantly ( P 0.01 ), but group A and group B had a significant difference compared with the group C ( P0.01), and there was also a significant difference between the group A and group B.ConclusionThe scalp point penetration combined with rehabilitation training can regulate the content of ET and CGRP in plasma and make them under a dynamic balance.


In this paper, turn-on and turn-off switching behavior of 650V enhancement-mode GaN power FETs are investigated. An analytical model is developed to analyze the current-voltage characteristics of the device during switching transients both with and without the effects of parasitic components. In addition, the effect of the temperature and circuit parameters on the switching characteristics are investigated.


Inefficient access/egress/processing (whether actual or perceived) may be a primary reason why people choose not to use certain airports in a metropolitan area, such as Newark International Airport and Dulles International Airport. Thus, inefficiencies in access/egress/processing can affect overall effective airside use and delay. Such inefficiencies can also result in the deferral of needed airside improvements, although such deferral may not be justified. In addition, all airport improvements must compete for limited financial resources and land. Passengers have more flexibility to adapt to congestion on the landside, compared with the flexibility aircraft opeators have to adapt to congestion on the airside. Therefore, one can usually assume that landside congestion has little effect on the capacity of the airside system. The subject of efficient airport access/egress/processing has been ranked as the least important of thee ten problem and action areas considered. The potential effects of landside congestion on airside capacity and delay, as described in this paper, are such that they should remain a low-priority concern of the Transportation Research Board Committee on Airfield and Airspace Capacity and Delay.


RAG1 and RAG2 catalyze the site‐specific DNA cleavage steps in V(D)J recombination, the programmed genetic rearrangement process that assembles antigen receptor gene from component gene segments during lymphocytes development. The first step in V(D)J recombination is the sequence‐specific association of the RAG proteins with the conserved recombination signal sequence (RSS), which flanks each gene segment in the antigen receptor loci. Questions remain as to the contribution of each RAG protein to recognition of the RSS. In this study, we examined the association of RAG1, with and without RAG2, to consensus 12‐RSS versus a non‐RSS substrate using both Fluorescence anisotropy and Electrophoretic Mobility Shift Assays. Our results indicate that while RAG1 only can recognize the RSS, the sequence‐specific interaction is masked by a high affinity non‐sequence specific DNA‐binding mode. RAG2 effectively inhibits the association of RAG1 with non‐sequence specific DNA, resulting in a large differential in binding affinity for the RSS versus non‐RSS sites. We conclude that this represents a major means by which RAG2 contributes to the DNA cleavage reaction. It is therefore likely that association of RAG1 with RAG2 is required for effective interaction with the RSS during V(D)J recombination.


The treatment of a commercial diesel with ozone was studied in order to improve the properties of the fuel with regard to Cetane index and undesirable emissions. Two products were generated by the treatment, a liquid phase and a solid phase. Both products showed higher molecular weight and lower interfacial tension than the original diesel. Compared with the original diesel, the liquid phase showed lower content of aromatics and carbonyl groups, whereas the solid phase showed higher content of aromatics and probably of acidic, carboxylic, aldehydes and ketones. By using the solid phase as a surfactant, w/o microemulsion was formulated (80% p/p liquid phase and 0.6 - 0.5% w/w solid-phase, 3-4.4% w/w of 1-hexanol as co-surfactant, and 15-17% w/w of water). Compared with the original diesel, the liquid phase presented a sulphur content equal to a desulfurization of 22% w/w and both the liquid phase and the w/o microemulsion showed a decrease of Ni content and an increase of the °API and the cetane index, indicating that both products may be used as fuels with higher power of ignition and lower toxicity than the original diesel.


From the Publisher:
VLSI is an important area of electronic and computer engineering: however, there are few textbooks available for undergraduate education in VLSI design automation and chip layout. VLSI Physical Design Automation fills the void and is an essential introduction for senior undergraduates, postgraduates and anyone starting work in the field of CAD for VLSI. It covers all aspects of physical design, together with such related areas as automatic cell generation, silicon compilation, layout editors and compaction. A problem solving approach has been adopted and each solution has been illustrated with examples. Each topic is treated in a standard format of Problem Definition, Cost Functions and Constraints, Possible Approaches and Latest Developments.


This study analyses various teaching and learning situations designed to improve certain competences in a non-formal educational context. During the sessions, an interactive projection system called Ninus is used. The activities are designed through gamification strategies and the creation of a teaching and learning environment which promotes motivation. As a case study, a qualitative analysis of video recordings of the work sessions is carried out. To analyse the data, we used a video analysis program (MED1C) to systematize the evaluation process. To evaluate participants' achievement in terms of the desired competences, a rubric was prepared and integrated into the video analysis system. This document defines performance levels based on Bloom's taxonomy. The analysis of the results shows that the use of Ninus as a didactic resource promotes motivation and makes it possible to carry out meaningful activities to develop competences.


Major burn injuries provoke a profound stress response marked by extreme hypermetabolism and impaired immune function. The physiological alterations to glucose, protein and lipid metabolism can be detected even years after the inciting burns injury and when untreated can lead to profound wasting, fatty liver, and even death. Therapeutic strategies which target these physiological disturbances are of paramount importance. Treating burn injuries begins with active cooling, to minimize loss of heat and water, and nutrition, to counteract the extensive catabolism. Providers should follow the strict guidelines published to ensure caloric requirements are met in adult and pediatric patients, with supplementation as indicated. Several pharmacotherapies have proven beneficial in helping to counteract and reverse these physiological changes by lowering insulin resistance, slowing catabolism, and minimizing loss of lean body mass. The most promising drugs include anabolic agents such as insulin, recombinant human growth hormone (rhGH), insulin-like growth factor 1 (IGF-1), metformin, beta-blockers, oxandrolone, and fenofibrate. Surgery is a necessary adjunct, either in the acute phase to debride compromised soft tissue and prevent compartment syndromes, but also in the chronic setting to release contractures and fibrotic strictures which may impair function. This narrative literature review provides a synopsis of our understanding of the hypermetabolic response to burn injury and discusses the different treatment options aiming to control postburn hypermetabolism and ultimately improve patient outcomes.


Universal antepartum serologic screening for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies can aid in properly applying isolation and visitation policies for patients presenting to labor and delivery.


Zhu Yuanzhang's birthplace should be based on his own narrative and the earliest official document,Fengyang Anhui.It cannot hold water that he was born in Xuyi and Mingguang.


Since this topic was last reviewed rapid advances have been made in our understanding of inherited metabolic disease.' Much of this increased knowledge has been stimulated by the application of molecular genetic techniques to the study of human disease. In addition clarification of the function of various subcellular organelles has led to the recognition of a number of new disease states. An aggressive approach to diagnosis and treatment remains the correct therapeutic option. The widespread availability of accurate imaging equipment and the advances in electrophysiological techniques have improved our ability to provide an early, accurate prognosis for most affected infants. Despite our increased understanding of the pathophysiology of inherited metabolic disease the long term prognosis for many disorders remains poor, especially in those infants where there is a significant delay between the onset of symptoms and diagnosis and treatment. Arteriovenous haemoperfusion is being increasingly used as the method of choice for removal of toxic intermediary compounds and peritoneal dialysis is reserved for those infants in whom vascular access is not possible. It is essential that the basic 'metabolic screen' is supplemented by a sample of blood (collected in a 5 ml EDTA tube) for subsequent DNA analysis. This is particularly important for infants suspected of having medium chain fatty acyl CoA dehydrogenase deficiency (MCAD) where analysis for the common mutation is often the quickest method of establishing the diagnosis and will detect 90% of cases within the white population.2 Management of a child with an inborn error of metabolism while awaiting results is still based on attempts to rapidly induce an anabolic state. Glucose and insulin and the use of lipid emulsions remain the major therapeutic thrust during this period, supplemented by arteriovenous haemoperfusion. The 'blunderbuss' approach to treatment using a megavitamin cocktail can no longer be routinely recommended. Specific vitamin treatment after diagnosis of a disorder known to be vitamin responsive is appropriate. The necropsy remains important in those infants for whom a diagnosis has not been found. In addition to blood, urine, cerebrospinal fluid, and skin fibroblasts, a muscle biopsy specimen should be collected and snap frozen. Muscle tissue is essential if a mitochondrial cytopathy is thought to be responsible for the infant's illness.


Software Product Line Engineering (SPLE) is a emerging software reuse paradigm. SPLE focuses on systematic software reuse from requirement engineering to product derivation throughout the software development life-cycle. Feature model is one of the most important reusable assets which represents all design considerations of a software product line. Feature model will be used in the product configuration process to produce a software. The product configuration is a decision-making process, where all kinds of relationships among configurable features will be considered to select the desired features for the product. To improve the efficiency and quality of product configuration, we are proposing a new approach which aims at identifying a small set of key features. The product configuration should always start from this set of features since, based on the feature dependencies, the decisions made on these features will imply decisions on the rest of the features of the product line, thus reduce the features visited in the configuration process. We have also conducted some experiments to demonstrate how the proposed approach works and evaluate the efficiency of the approach.


The development of a multi-metric fish index, the Estuarine Fish Community Index (EFCI), for assessing estuarine environments is described. The index comprises 14 metrics or measures that represent four broad fish community attributes: species diversity and composition, species abundance, nursery function and trophic integrity. The individual metrics were evaluated using data that were collected on a South African estuary that was degraded and in which rehabilitation measures were implemented. The evaluation suggested that the selected metrics adequately measure the condition of separate but related components of estuarine fish communities and that these reflect environmental condition. Reference conditions and metric thresholds were derived from fish community data collected during an extensive national study. The final multi-metric index was then constructed and evaluated. The EFCI combines both structural and functional attributes of estuarine fish communities and integrates these to provide both a robust and sensitive method for assessing the ecological condition of estuarine systems. It is also an effective communication tool for converting ecological information into an easily understood format for managers, policy makers and the general public.


Staphylococcus aureus is the most common agent of septic arthritis (SA) that is a severe, rapidly progressive and erosive disease. In this work we investigated the clinical, histopathological and immunological characteristics of the SA triggered by an enterotoxin C producer S. aureus strain. The effect of a β‐lactamic antibiotic over disease evolution and cytokine production was also evaluated. After confirmation that ATCC 19095 SEC+ strain preserved its ability to produce enterotoxin C, this bacteria was used to infect C57BL/6 male mice. Body weight, clinical score and disease prevalence were daily evaluated during 14 days. Cytokine production by splenocytes, cytokine mRNA expression in arthritic lesions, transcription factors mRNA expression in inguinal lymph nodes and histopathological analysis were performed 7 and 14 days after infection. ATCC 19095 SEC+ strain caused a severe arthritis characterized by weight loss, high clinical scores and a 100% disease prevalence. Histopathological analysis revealed inflammation, pannus formation and bone erosion. Arthritis aggravation was associated with elevated production of pro‐inflammatory cytokines, higher local mRNA expression of these cytokines and also higher mRNA expression of T‐bet, ROR‐γ and GATA‐3. Disease control by cloxacillin was associated with decreased production of pro‐inflammatory cytokines but not of IL‐10. These findings indicate that the ATCC 19095 SEC+ strain is able to initiate a severe septic arthritis in mice associated with elevated cytokine production that can be, however, controlled by cloxacillin.


1 ACL2 Workshop 2000 00-lusk-parallel[11] ACL2 for Parallel Systems Software: A Progress Report 00-wilding-stobj[42] Using a Single-Threaded Object to Speed a Verified Graph Pathfinder 00-sumners-bdds[54] Correcness Proof of a BDD Manager in the Context of Satisfiability Checking 00-shumsky-sdl[44] Developing a Framework for Simulation, Verification and Testing of SDL Specifications 00-manolios-pipeline[46] Verification of Pipelined Machines in ACL2 00-sumners-stuttering[53] An Incremental Stuttering Refinement Proof of a Concurrent Program in ACL2 00-reina-multiset[18] Multiset Relations: A Tool for Proving Termination 00-goerigk[74] Proving Preservation of Partial Correctness with ACL2: A Mechanical Compiler Source Level Correctness Proof 00-sawada-computed[34] ACL2 Computed Hints: Extension and Practice


A recognition system which represents object categories by properties which can he deduced by analysis of 3-D shape has been implemented and tested using the category " chair" for case study. Functional description is used to recognize classes and identify subclasses of known categories of objects even if the specific object has never been encountered previously. Interpretation of the functionality of an object is accomplished through qualitative reasoning about its shape. This is to our knowledge the first implemented system to explore the use of purely function-based representation (that is no geometric or structural object model) to recognize 3-D objects. During the recognition process evidence is gathered as to how well the functional requirements are met by the Input structure. This paper is concerned with choosing the type of operators that will be used in the combination or accrual of the functional evidence. Three pairs of conjunctive and disjunctive operators aie evaluated. Each pair is uSe(i in the recognition process of the 100+ test objects. The results of all tests run are compared and diffeieiices are discussed.


e19552 Background: Leukemic involvement (LI) in diffuse large B cell lymphoma (L-DLBCL) is very rare and has been sparsely reported. We report our experience with this entity in a large academic multi-center setting. Methods: Medical records of patients with DLBCL who received care at Mayo Clinic between 1/2003 and 6/2020 were reviewed. DLBCL patients with LI were identified. LI was defined as increased white blood cell counts and the presence of clonal B cells on peripheral blood flow-cytometry. Kaplan-Meier method was used for survival analysis. Results: Twenty patients with L-DLBCL were identified with a median follow-up of 32.5 months (CI95%, 32.5-NR). Median age at initial diagnosis was 62 (45-80) years. 60% (12/20) were male; 90% (18/20) were Caucasian. Pathologically, 90% (18/20) had DLBCL and 10% (2/20) had high-grade B cell lymphoma (HGBCL) with intermediate features between DLBCL and Burkitt lymphoma. By Hans criteria, 58% (11/19) had germinal center B-cell DLBCL (GCB-DLBCL) and 42% (8/19) had non-germinal center B-cell DLBCL (non-GCB-DLBCL). 40% (8/20) had transformed DLBCL (t-DLBCL); 36% (5/14) had double-hit lymphoma (DHL) by FISH analysis. LI was present in 55% (11/20) at initial diagnosis and 45% (9/20) at relapse. Median WBC was 39.5/ul (range, 4.3-121) with median absolute lymphocyte count of 25 k/ul (range, 0.7-117). Immunophenotypically, the leukemic lymphoma cells expressed CD19, CD20, and CD79a. Bone marrow involvement and pancytopenia were documented in all patients with a median bone marrow cellularity of 80%. Other extranodal sites of involvement with LI included spleen (65%;13/20), liver (20%;4/20), breast and soft tissue (20%;4/20), bladder or kidneys (10%;2/20), skeleton (10%;2/20), and myocardium (5%;1/20). 65% (13/20) had B-symptoms. All patients had LDH elevation (UNL 222 U/L) with a median of 2125 U/L (range, 308-10,760). 45% (5/11) of patients with LI at initial diagnosis had CNS involvement on relapse/progression. All patients with LI at initial diagnosis received anthracycline-based chemoimmunotherapy with or without CNS prophylaxis. Patients with LI at relapse had had a median of 2 prior treatments (range, 1-5) before LI. Median overall survival (OS) for the whole group was 9 months (CI 95%; 5.8-11.8). There were no long-term survivors. Median progression free survival after LI was 4.7 months (CI95%; 0.8-7.6) in the newly diagnosed group and 3 months (CI95%; 0.9-20) in the relapsed group. 90% (18/20) died due to their progressive disease. Cell of origin, DHL status, or newly diagnosed vs. relapsed status did not have a significant impact on OS in patients with L-DLBCL. Conclusions: Leukemic involvement at any time during the course of DLBCL is associated with poor prognosis. It also appears to be a major risk factor for CNS relapse. It is most frequently associated with DHL and t-DLBCL. Novel therapeutic approaches at the time of initial therapy need to be developed for L-DLBCL.