Prescriptive process monitoring methods seek to optimize the performance of business processes by triggering interventions at runtime, thereby increasing the probability of positive case outcomes. These interventions are triggered according to an intervention policy. Reinforcement learning has been put forward as an approach to learning intervention policies through trial and error. Existing approaches in this space assume that the number of resources available to perform interventions in a process is unlimited, an unrealistic assumption in practice. This paper argues that, in the presence of resource constraints, a key dilemma in the field of prescriptive process monitoring is to trigger interventions based not only on predictions of their necessity, timeliness, or effect but also on the uncertainty of these predictions and the level of resource utilization. Indeed, committing scarce resources to an intervention when the necessity or effects of this intervention are highly uncertain may intuitively lead to suboptimal intervention effects. Accordingly, the paper proposes a reinforcement learning approach for prescriptive process monitoring that leverages conformal prediction techniques to consider the uncertainty of the predictions upon which an intervention decision is based. An evaluation using real-life datasets demonstrates that explicitly modeling uncertainty using conformal predictions helps reinforcement learning agents converge towards policies with higher net intervention gain


Objective To compare the characteristics of suicidal behavior between rural young male and female completed suicides.Methods From 16 counties or county-level cities in Liaoning,Shandong,and Hunan provinces,we consecutively sampled randomly 392 completed suicides aged 15-34 years.We used psychological autopsy method to investigate 784 informants of the 392 completed suicides with face-to-face interviews.Results The peak suicide periods for male suicides were from 30th April to 16th July,while for female suicides they were from 21th June to 21th September.The peak suicide time for male suicides was from 11:21 am to 3:49 pm,while for female suicides was from 11:03 am to 1:56 pm.Compared to male suicides,the female suicides were more likely to commit suicide indoor(χ2=3.91,P0.05) and use a moderate method(ingestion of poison) for suicide(χ2=7.27,P0.01).Both the male and female suicides had medium suicidal intents(8.40±3.33 for male,8.13±3.23 for female),but there was no significant gender difference(t=0.81,P0.05).However,female suicides had significantly less preparation than their counterparts before suicidal behavior(χ2=6.54,P0.05).Conclusion There are certain differences in suicidal behaviors between Chinese rural young men and women.


Living and working among the Tz'utujil Maya people of Santiago Atitlan in highland Guatemala for some fifteen years, Vincent Stanzione has observed, photographed, and participated in their ritual and ceremonial life, which he describes with unique authority in this account of the continuities in Mayan culture from pre-Columbian times to the present.


Increased use of biogas in energy production and transportation is necessary to reduce greenhouse gas emissions and dependency of imported fossil fuels in the EU. To support this, quality specifications for biogas is under development specifying, among other things, limit values for impurities including the requirement of particle free biogas. At the moment, however, the particle concentration of biogas is not monitored. In this study, the need and appropriate methods for measurement based quality control was investigated. Biogas was sampled at the Kujala biogas production and upgrading facility in Lahti, Finland. Both off-line measurements of bottled biogas and on-site measurements were performed. Results indicate that the particulate content of biogas is very low even before any processing, and thus measurement based quality control is not necessary. However, the particulate content probably depends on the specific biogas production process and thus it must be assessed for each process separately. The measurement of particulate content of biogas should preferably be performed on-line, because sampling and storing biogas in gas bottles results in significant particle losses.


I write—I write again—1 write a third time, in the course of six months— then I take the third—I literally fill the paper with corrections so that another person could not read it—I then write it out fair for the printer—I put it by—I take it up—I begin to correct again—it will not do—alterations multiply—pages are re-written—little lines sneak in and crawl about—the whole page is disfigured—I write again. I cannot count how many times this process goes on.4


[Objective] To establish an QNMR method for the determination of methanol, ethanol and acetic acid in Salvianolic acid B.[Methods] The1H-NMR spectra was performed on a Bruker AV Ⅲ 600 MHz NMR spectrometer with a proton frequency of 600.23 MHz and a temperature of 298 K. [Results] Each experiment consisted of 16 scans with a spectral width of 12 019.2 Hz and a recycle delay of15 s per scan. All the calibration curves showed good linearity(r20.999 5) in the range of 1.22~2 430 mg/L. The average recoveries were105% ~109%(n =6). [Conclusion] The method is rapid and accurate, which is helpful for the determination of the residua1 organic solvents in Salvianolic acid B.


The landscape of early breast cancer has changed dramatically with significant advancements in early screening and diagnosis and curative-intent therapies. Indeed, breast cancer–specific survival has improved by 20% during the past 30 years, and 5-year survival is now 98% for early-stage disease.1 As a consequence, the risk and nature of adjuvant therapy–induced immediate and late-occurring cardiovascular injury have similarly evolved. In women with early breast cancer, particularly those >65 years of age, cardiovascular disease (CVD) is now the predominant cause of mortality as indicated by Surveillance, Epidemiology, and End Results (SEER)–Medicare linked data.2 Additionally, these women are also at increased risk of CVD compared with age-matched women without a history of breast cancer.3

Significant cardiac safety concerns about anticancer therapy were first described by Von Hoff and colleagues,4 identifying dose-dependent and progressive left ventricular (LV) dysfunction manifesting as symptomatic heart failure in patients receiving anthracyclines. From this work and others,5,6 anthracycline-induced cardiac toxicity7,8 is now a well-recognized adverse side effect. More recently, randomized trials have demonstrated that human epidermal growth factor receptor 2 (HER2)–directed monoclonal antibodies (ie, trastuzumab) and newer multitargeted small-molecule inhibitors interfere with molecular pathways crucial to normal cardiac homeostasis,9 resulting in relatively high incidences of subclinical and overt cardiac toxicity.10 Although cardiac toxicity with newer therapies has demonstrated reversibility,11 recovery of LV function after treatment cessation is uncertain at this time.12 Thus, to identify those individuals at high risk of cardiac toxicity, baseline measurement of LV ejection fraction (LVEF) is recommended by the American College of Cardiology (ACC) and American Heart Association (AHA) as standard of care for all breast cancer patients being considered for potentially cardiac-toxic treatment regimens.13,14 In addition, measurement …


By nitrogen ion implanting, we obtained a semi-dwarf mutant from a japonica rice cultivar Y98148, designated as Y98149. The genetic analysis of Y98149 indicated that the semi-dwarf phenotype was controlled by a single dominant gene, Sdd(t). We show that Y98149 reduced plant height mainly via inhibiting the first, second and third internode elongation. Based on this dwarfing pattern, the mutant could be grouped into dn-type dwarf defined by Takeda [Gamma Field Symp. (1977) Vol. 16, PP. 1-18]. In addition, the Sdd(t) gene was sensitive to gibberellin (GA) based on the response to extraneous GA 3 and the quantitative determination of endogenous GA 1 and GA 4 . To map the Sdd(t) gene, we tested molecular markers by bulk segregant analysis. The Sdd(t) gene was localized to a 6.4 cM-interval on the short arm of chromosome 6, flanked by two sequence-tagged site markers S9 and S 13.


Family-managed firms take actions to protect their reputations. We theorize that one such action involves avoiding corporate political activity (CPA) that expose firms to social attack, especially when also invested in corporate social responsibility. Because large firms are frequent targets for social attack, the same sensitivity that encourages most family managers to avoid CPA encourages it among the largest as a buffer. Supportive analysis of Standard and Poor's 500 firms shows that family-managed firms spend, on average, 86% less on CPA, even less when invested in substantive corporate social responsibility. The largest invest as much or more in CPA as nonfamily peers.


A variety of neurological disorders including Alzheimer's disease are associated with the formation of neurofibrillary tangles, made up by intraneuronal paired helical filaments (PHFs) that are composed of hyperphosphorylated tau protein. The phosphorylation of tau is assumed to be crucial for aggregation; however, the underlying mechanisms are not well understood. Several kinases have been identified as potential candidates for the abnormal phosphorylation under pathological conditions. Nevertheless, based on the lack of appropriate models the actual relevance of these enzymes could not be studied concertedly under physiological conditions. Recently, we described the reversible formation of highly phosphorylated tau protein in hibernating animals under physiological conditions. Using hibernation as a model we determined the activity profile of four major tau kinases in three different species to analyse the state-dependent regulation of these enzymes and reveal the importance of each kinase for tau phosphorylation.


The literature on populism refers both to empirical facts, such as the expansion of electoral support for populist parties across Europe and on almost all other continents (Gherghina et al. 2013), and to the so-called perception of a major challenge for contemporary democracies (Mudde 2007). This is also the case in Central and Eastern Europe, where most of the research uses the common denominator of "the worshipped people" (Ionescu and Gellner 1969: 4) to assess populism and its variants. More recent studies have also shown the utility of using populism as a scale, implying that parties can be assessed as more populist or less populist.
This chapter aims to provide an overview of populist parties across Central and Eastern Europe with a focus on six countries (Bulgaria, the Czech Republic, Hungary, Poland, Romania and Slovakia) between 1990 and 2016.


We show the existence of common fixed point and a coincident point for two weakly compatible selfmappings defined on a complete partial S-metric space X, where the contraction in the assumption of the main result has three control functions, α,ψ, φ. c ©2016 All rights reserved.


This paper investigates the importance of the visual domain in the (new) economy of signs. By analyzing two cases of visualization of events (Croatian War of Independence and the Ukrainian crisis), the paper reiterates the need for visual studies to reconsider the social and cultural impact of the symbolic capital. Furthermore, this paper seeks to acknowledge the manipulation of media in the digital realm, evoking an understanding of the structural complexities of new media and proposing a model which would include an inter-subjective understanding of the media dialectics.


This article presents an innovative open-source software named ModelFLOWs-app, written in Python, which has been created and tested to generate precise and robust hybrid reduced order models (ROMs) fully data-driven. By integrating modal decomposition and deep learning methods in diverse ways, the software uncovers the fundamental patterns in dynamic systems. This acquired knowledge is then employed to enrich the comprehension of the underlying physics, reconstruct databases from limited measurements, and forecast the progression of system dynamics. These hybrid models combine experimental and numerical database, and serve as accurate alternatives to numerical simulations, effectively diminishing computational expenses, and also as tools for optimization and control. The ModelFLOWs-app software has demonstrated in a wide range of applications its great capability to develop reliable data-driven hybrid ROMs, highlighting its potential in understanding complex non-linear dynamical systems and offering valuable insights into various applications. This article presents the mathematical background, review some examples of applications and introduces a short tutorial of ModelFLOWs-app.


Summary form only given. This video shows a light hearted view of a rolling autonomous robot named Roball. Roball is shown interacting with various children who age from 10 months old to teenagers at a high school. The clips show the different ways children interact with Roball and also the different types of reactions the children can have to Roball. Each clip was taken from a trial that was conducted to investigate Child-Robot Interaction (CRI). First we see the different reactions of young children (tikes) aged between 2 to 4 years. We see them laughing, chasing Roball, dancing to music that Roball is playing and also running away from Roball. It is possible to see how active this age group can be in there interaction. Next we see a 10 month old toddler enjoying hitting Roball and then we see this child apparently showing some form of affection to Roball. Then after watching Roball bang into a door we see the toddler copy the behaviour by also banging into the door. Proceeding is the very different style of interaction from teenagers. Despite Roball gaining a lot of interest the actual physical contact or interaction is much lower. We see the robot being purposefully kicked and also a teenager pretending to kick Roball in a show of bravado. Finally we see the dangers of being a rolling robot when in the presence of a group of teenagers, as Roball through random wandering rolls into the path of a group of teenagers walking at high speeds.


A case of toxic psychosis due to cycloplegic eyedrops is reported. The characteristic mental symptoms of atropine intoxication include confusion with vivid visual hallucinations, restlessness, muscular incoordination, and later emotional lability. These symptoms and a short period of retrograde amnesia occurred in our patient. The adverse drug reaction was confirmed following rechallenge. The possible preventive measures against intoxication caused by atropine eyedrops are described. All healthcare professionals should be aware of the possible temporal relationship between the appearance of pathology and the administration of a drug. TOXIC PSYCHOSIS due to anticholinergic eyedrops is well documented in the medical literature, although there are few detailed cases. We report a case of toxic psychosis due to cycloplegic eyedrops in which the cause was documented by rechallenge.


THE INCREASED volume and variety of clinical laboratory tests require new approaches in presenting data to the physician so that reports are clear, concise, and informative. In addition, the need for a logical series of data to answer a physician's query has induced us to assemble laboratory tests into studies geared to a specific purpose. As an example, we present a study to determine maternal candidacy for anti-Rho immune globulin serum after pregnancy to prevent Rho-sensitization, with data plus interpretation reported via a programmable calculator.1The study also checks for maternal-fetal ABO incompatibility, and, if present, for homologous antibodies in the infant's cord blood.2 Programmable Calculator Two major problems arise from this approach to laboratory testing. First, since the study is based on a variable sequence of tests from which subsequent tests are selected according to the result of a preceding test, the series must be monitored for


Abstract The leaf oil of Hexalobus monopetalus (Annonaceae) from Benin was analyzed by high resolution GC and GC/MS. Forty components were identified, representing more than 95% of the oil. The main constituents were geranial (37.9%), neral (30.9%), linalool (3.5%), (E)-anethole (2.6%), selin-ll-en-4α-ol (2.5%) and caryophyllene oxide (2.4%).


Based on the corrosive expansion force of reinforced concrete member in Reference [1],the formula of strain energy release rate for crack propagation in corrosive reinforced concrete members was presented by fracture mechanics approach.The double-G fracture criterion was applied on the prediction of crack propagation life-span of corrosive reinforced concrete,and the factors that affect crack propagation life-span,such as the grade of concrete strength,the depth of concrete cover and the rebar diameter,were investigated in detail.The results show that(1) there is a great effect on the life-span of initiation crack expansion,stable crack expansion and unstable crack propagation due to the initial crack length of concrete members;(2) to increase of rebar diameter and concrete strength will enhance life-span of crack propagation,and to increase thickness of concrete cover will cause the life-span of crack propagation decreased in some way.Therefore,it is extremely important to design reasonable concrete cover thickness for improving the durability of concrete structures.


Semantic Web enables new accessing and managing methods of Web resources. The realization of Semantic Web is based on the availability of rich semantic infrastructure. Activities of building semantic infrastructure are usually collaborative and infrequent. Low coverage to personal interests of semantic infrastructure prevents developers from building personalized Semantic Web applications. In contrast to activities of building semantic infrastructure, press clipping or Web contents bookmarking are common events in our daily lives. In addition to the relatively higher frequency, press clipping and Web contents bookmarking clearly reflect personal interests, which is a clearer goal for accumulating personalized semantic infrastructure. In this paper, an interest-driven development method (IDD) is used to solve the availability problem of semantic infrastructure. An architecture, called IDEA, is proposed to assist the interest-driven development and evolution of personalized semantic infrastructure through clipping Internet media of personal interests.


Thisis a quantitative study with 67 children, between 05 and 11 yearsold, grouped as follows: A1 (patients with cleftlipandpalate; n = 21), A2 (normorreative childrenlinkedto a privateschool; n = 23) and A3 ( normorreative children linked to the public school; n = 23), A1 beingthe case groupand A2 and A3 thecontrolgroups. Anamnesis, cognitive evaluation, medical records verification, quality of life analysis and oral health quality assessment were made with the need toob tain correlations. The sample distribution was similar too ther studies. In A1, a fissure transforms the numerical relation ship with intelligence belo wtheaverage (n = 5). The Group A2 showed higher socioeconomic scores in contrastto A1 and A3, un related to cognition. In A2, the social disability do mainisaffected with below-averageintelligence (p = 0.005), which does notoccur in theother do mainsof oral health quality in thesa megroupand A1 and A2. In the quality of life A1, there achdomain shows number slessthan A2 and A3, with no correlation with the type sofintelligence; with other domains similar too ther studies. There fore, thecognition of children with nonsyndromic orofacial cleft does not show a significant relations hipwith quality of life, qualityof oral heal thand socioeconomic profile. There fore, theim portance of multiprofession altreatmentand its impacton the normalization of the life of a fissured child is evident.


Deploying Function-as-a-Service (FaaS) applications to resources in the Cloud-Edge continuum calls for suitable simulation environments to assess new proposals for managing those applications while accounting for their specificity, i.e. ephemeral deployment and orchestrated execution. Indeed, exploiting real infrastructures for extensive experiments, while considering heterogeneous nodes and different applications, is costly and time-consuming. In this article, we propose a novel open-source discrete-time simulator for the management (i.e. deployment and migration) of orchestrated FaaS in the Cloud-Edge continuum. It enables assessing customised management policies against varying infrastructure conditions. It collects data about execution time, energy consumption, and successes/failures of management operations. We illustrate the prototype at work over a lifelike case study.


Drought causes insufficient soil moisture and crop water balance damage. One of the most commonly used indicators in drought monitoring is the Standardized Precipitation Evapotranspiration Index (SPEI). In this study, the performance of the SPEI at 1-, 3-, 6-, 9-, and 12-month timescales was compared and analyzed from temporal and spatial variations at 12 meteorological stations in the Barmer arid region from 1979 to 2013. To determine the significance of drought characteristic trends, the modified Mann-Kendall (M-K) test is used. The results revealed that as the timescale increased, the temporal variations in the SPEI became more consistent. The M-K test revealed that the SPEI showed decreasing trends at 1 and 3 months, but increasing trends at 6, 9, and 12 months. The findings of this study are instructive and practical for drought assessment, risk management, and decision-making.


From 15 to 20% of the RNA of virulent strains of poliovirus is degraded at 35 °C several hours after maximal synthesis is reached. From 20 to 30% of the RNA of attenuated viruses is degraded under the same conditions. Cultures placed at 40 °C in the presence of 3 mM guanidine during the linear stage of RNA synthesis lead to breakdown of 15 to 40% of the RNA of virulent viruses and 30 to 40% of the RNA of attenuated viruses. It is doubtful that breakdown of RNA alone can explain the temperature sensitivity of attenuated viruses.


Syndromic microphthalmia‐9 (MCOPS9) is a rare autosomal recessive disorder caused by mutations in STRA6, an important regulator of vitamin A and retinoic acid metabolism. This disorder is characterized by bilateral clinical anophthalmia, pulmonary hypoplasia/aplasia, cardiac malformations, and diaphragmatic defects. The clinical characteristics of this disorder have not been fully determined because of the rarity of clinical reports.


A recently published report suggested that young hyperopes are more likely to manifest substandard visual perceptual skills than are young emmetropes and myopes. This study addresses some of the clinical implications of that proposition by comparing the visual perceptual skills of 48 six‐to‐twelve‐year‐old hyperopes (> 2.25D), some of whom (N = 18) obtained their first glasses before their fourth birthday, the others (N = 30) after that time. Data are presented that (a) corroborate the above cited report there is a high prevalence of visual perceptual skills deficits among young hyperopes;(b) support the notion that early application of lenses for hyperopia is likely to contribute to the ultimate development of adequate visual perceptual skills: the hyperopic children in this study who started to wear glasses before age four manifested far fewer visual perceptual skills delays than did those who began to wear glasses after their fourth birthday.


Introduction: IgM light chain amyloidosis (AL) is a rare complication of IgM associated disorders, with very limited data on biology and outcomes. Our study compares the clinical characteristics, laboratory findings and outcomes in a large cohort of patients with IgM vs. non-IgM AL to delineate the underlying disease biology of this entity.
 Methods: Patients with newly diagnosed AL (2006-15) were identified from a prospectively maintained institutional database and grouped by IgM heavy chain. Bone marrow (BM) morphology was reviewed by an expert hematopathologist (RLK). FISH testing included probes for t(11;14) and trisomies of odd numbered chromosomes. MYD88L265P testing was carried out by allele specific PCR and CXCR4WHIM mutation testing was performed by bridged nucleic acid (BNA)-enhanced Sanger sequencing.
 Results: Patients with IgM AL comprised 6.6% (75/1128) of the study cohort. Baseline characteristics are listed in Table 1. IgM AL patients were older and had a higher proportion of males. They had less frequent cardiac involvement (60 vs. 75%) and less frequent involvement of > 1 organ. Light chain burden was lower in this group (dFLC 12.5 vs. 22.7 mg/dL), while there was no difference in BM clonal cell percentage (10% each).
 Morphology: BM morphology in 71 patients with IgM AL revealed a pure plasma cell disorder (PPCD type) in 25% (n=18); low-grade B-cell lymphoma (LGBCL) with plasmacytic features (LPL type) in 62% (n=44) [well defined LPL: 38% (n=27), LGBCL with plasmacytic features: 24% (n=17)]; LGBCL, other: 6% (n=4). In the remaining 7%, three patients had other diagnoses and no BM disease in two patients. Median clonal cell % in LPL vs. PPCD type IgM AL was 20% vs. 5%, p<0.001.
 Genetics: In patients with IgM AL vs. non-IgM AL, t(11;14) was present in 27% vs. 49%, p=0.009 and trisomies in 9% vs. 24% of patients, p=0.06, respectively. In the IgM AL cohort, MYD88 mutation was seen in 56% (23/41) & CXCR4 mutation in 15% (5/34; S388 type: 3, other: 2) of patients. Importantly, MYD88 and CXCR4 mutations were found only in patients with LPL morphology, while t(11;14) was found only in the PPCD morphology group. There were no patients with both t(11;14) and MYD88 abnormalities (N=26 for both tested). Mutations seen in the LPL vs. PPCD type IgM AL were: MYD88, 88% (22/25) vs. 0% (0/14), p<0.001 and CXCR4, 26% (5/19) vs. 0% (0/13), p=0.02. Conversely, t(11;14) was seen in 0% (0/18) in LPL type vs. 60% (9/15) in PPCD type IgM AL, p <0.001.
 Treatment details were known in 63 patients with IgM AL; rituximab-based: 21 (33%), bortezomib/alkylator: 16 (25%), transplant 17 (27%), steroids: one and no treatment: 8 (13%). Treatment in IgM AL LPL type (n=36) was: rituximab based: 16 (44%),bortezomib/alkylator: 5 (14%), transplant: 10 (28%) and none: 5 (14%). In PPCD type [n=17), treatment was rituximab based: 2 (12%), bortezomib/alkylator: 8 (47%), transplant: 7 (41%). At 6 months, very good partial response or better was observed in 26% (10/39) vs. 41% (270/660) of patients with IgM vs. non-IgM AL, p=0.05.
 There was no difference in overall survival (OS) when all patients with IgM AL were compared to non-IgM AL (Fig 1a). However, when stratified by early (Stage 1/2) or advanced (stage 3/4) 2012 Mayo stage, patients with IgM AL fared worse (Fig 1b-c). On multivariate analysis, IgM AL was an independent predictor for inferior OS [HR with 95% CI: 1.6 (1.1-2.4), p=0.02] after adjusting for age, Mayo 2012 stage and type of therapy (transplant vs. not). However, when OS was adjusted for 6 month VGPR, there was no difference in OS for IgM AL vs. non IgM AL, p=0.2. In the IgM AL cohort, patients with LPL type IgM AL had inferior OS compared with PPCD type IgM AL, 21 vs. 82 months, p=0.01 (Fig 1d).
 Conclusions: Patients with IgM AL have distinct clinical and genetic features, with lower rates of cardiac involvement and a lower frequency of t(11;14) or trisomies compared with non-IgM AL. Even though IgM AL is a rare entity, we were able to delineate two distinct sub-types of IgM AL: LPL type and PPCD type, with implications for therapy and outcomes. Along with unique morphologic findings, presence of MYD88 and CXCR mutations was only seen in LPL type IgM AL and t(11;14) in PPCD type IgM AL. Despite lower cardiac involvement, IgM AL was associated with inferior OS outcomes, likely due to lower response rates, particularly in LPL IgM AL group, which had the lowest OS. Therapeutic approaches targeted towards disease biology to achieve deep responses are needed in this disorder.

 Sidana: Janssen: Honoraria. Dispenzieri:Celgene, Takeda, Prothena, Jannsen, Pfizer, Alnylam, GSK: Research Funding. Kapoor:Takeda: Research Funding; Celgene: Research Funding. Lacy:Celgene: Research Funding. Kumar:Celgene: Membership on an entity's Board of Directors or advisory committees, Research Funding; KITE: Membership on an entity's Board of Directors or advisory committees, Research Funding; Celgene: Membership on an entity's Board of Directors or advisory committees, Research Funding; KITE: Membership on an entity's Board of Directors or advisory committees, Research Funding; Janssen: Membership on an entity's Board of Directors or advisory committees, Research Funding; Takeda: Membership on an entity's Board of Directors or advisory committees; Roche: Research Funding; Novartis: Research Funding; Merck: Membership on an entity's Board of Directors or advisory committees, Research Funding; AbbVie: Membership on an entity's Board of Directors or advisory committees, Research Funding; Oncopeptides: Membership on an entity's Board of Directors or advisory committees; AbbVie: Membership on an entity's Board of Directors or advisory committees, Research Funding; Janssen: Membership on an entity's Board of Directors or advisory committees, Research Funding. Gertz:Abbvie: Consultancy; Ionis: Honoraria; spectrum: Consultancy, Honoraria; Apellis: Consultancy; Amgen: Consultancy; Prothena: Honoraria; Teva: Consultancy; Alnylam: Honoraria; celgene: Consultancy; Medscape: Consultancy; janssen: Consultancy; Research to Practice: Consultancy; Physicians Education Resource: Consultancy; annexon: Consultancy.


92 English translation © 2006 M.E. Sharpe, Inc., from the Russian text © 2005 MiklukhoMaklai Institute of Ethnology and Anthropology, Russian Academy of Sciences. "Natsional'noe i etnicheskoe kak konstrukty i/ili iavleniia grazhdanskogo obshchestva: otvet opponentam," Etnograficheskoe obozrenie, 2005, no. 1, pp. 92–101. Alisher Ilkhamov is a candidate of philosophical sciences and a scientific researcher at the School of Eastern and African Studies, University of London. In 2001–4 he was director of the Open Society Institute Assistance Foundation—Uzbekistan. Translated by Anya Bernstein. Anthropology & Archeology of Eurasia, vol. 44, no. 4 (Spring 2006), pp. 92–102. © 2006 M.E. Sharpe, Inc. All rights reserved. ISSN 1061–1959/2006 $9.50 + 0.00. DOI 10.2753/AAE1061-1959440413


Aiming at the characteristics of curriculum of biomedical engineering and functions of LabVIEW software,this paper proposed the application of LabVIEW in biomedical engineering teaching by combining hardware with virtual experiments.A virtual EEG experimental instrument was designed.Firstly,EEG signal is magnified and filtered via weak signal processing box,and then virtual instrument is used to achieve the acquisition,storage,display and frequency domain analysis of EEG signal.


H transport costs pose a significant barrier to development in africa. Causing friction in the movement of labour and goods, transport costs effectively reduce the markets for labour and goods, and for the transmission of knowledge and technologies. Reducing transport costs in contemporary Africa has become even more of a priority, with many countries having reduced tariffs on their international trade, and as protectionism in developed countries are scaled down. The success of Africa's exports, as well as its rural and more generally its spatial development, now depend on lowering its transport costs. This Policy Brief addresses a number of pertinent questions on transport costs in Africa, such as 'what are transport costs?', 'do transport costs matter for trade?', 'how important are transport costs in practice?', and 'why are Africa's transport costs so high?'. We present a case study of the firm location decisions of exporters in South Africa to illustrate the significance in particular of domestic transport costs for international trade. We conclude by discussing various policy options that can be taken to reduce transport costs in Africa.


The well-known range-Doppler coupling property of the chirp radar makes it more vulnerable to different types of deceptive repeater jammers that benefit from the pulse compression processing gain of the radar-matched filter. These jammers generate many false targets that appear before and after the true target. Therefore, the radar cannot distinguish the true target from the false ones. This paper reviews different self-protection repeater jammers and presents their pros and cons, in order to provide a reference for the study of jamming/anti-jamming methods.


This chapter assesses divination. Divination consists of soliciting and receiving messages from the gods; it is in some sense the reverse of prayer, since it is communication from gods to mortals. As with prayer, divination is an area in which the definition of magic as an extraordinary form of ritualized action becomes particularly useful. Like prayer and sacrifice, divination forms a large part of the order of normal religion in the Greco-Roman world, so divination is only labeled "magic" when it makes claims to authority far outside this normal order, either as a superlatively efficacious procedure that depends on specialized arcane knowledge or, conversely, as a bit of traditional superstition that seems ineffective in comparison with the normally accepted procedures. Technical, indirect, or artificial divination consists in the observation of significant phenomena and the puzzling out of the significance, whereas natural or inspired divination does not rely on such interpretive techniques but rather on interpersonal communication with the divine.


In the future UMTS system (Universal Mobile Telecommunications System) one modulation technique which performs well in microcellular as well as macrocellular environments would clearly be attractive. In this paper, novel variable-envelope modulation schemes which attempt to combat the problems of current constant-envelope techniques have been examined. Performance for these schemes has been extensively evaluated for a range of receiver architectures.


Welding process with trailing heat sink for 2 mm mild steel plates has been analyzed to estimate distortion and residual stresses using a finite element modeling software Sysweld. The material properties used for the analysis are both temperature dependent and phase dependent. A transient thermal analysis is carried out using Goldak double ellipsoidal heat source model and heat sink as Gaussian model with negative heat flux. The finite element analysis (FEA) is conducted by considering the material properties of all phases of steel as well as without phase transformation i.e. by considering properties of only ferrite phase. Temperature distribution, distortion and residual stresses are calculated and compared for four cases: without phase without cooling, without phase with cooling, with phase without cooling and with phase with cooling. It is found that FEA without phase transformation effects overestimates the residual stresses in the fusion zone (FZ) and heat affected zone (HAZ). It is also found that a trailing heat sink reduces transverse compressive residual stresses thus minimizing the possibilities of buckling.


Hong Kong Medical Journal ©2019 Hong Kong Academy of Medicine. CC BY-NC-ND 4.0 A 15-year-old Chinese girl with a history of scoliosis presented to Queen Mary Hospital, Hong Kong in April 2016 with an incidental finding of an ejection systolic murmur at the left lower sternal border. No history of chest pain, syncope, reduced effort tolerance, or significant family history of congenital cardiac disease was present. Echocardiography revealed heavy trabeculations over the left ventricular (LV) apical region. Colour Doppler revealed abnormal inand-out flow at the deep crypts. Overall features were suspicious of LV non-compaction (NC). The patient subsequently underwent cardiac magnetic resonance imaging for further assessment, using a 1.5-T magnetic resonance imaging scanner (Magnetom Aera; Siemens Healthcare, Forchheim, Germany). Cardiac magnetic resonance confirmed the diagnosis of biventricular NC with diffuse involvement (Fig 1). The ratio of non-compacted to compacted diastolic myocardium was 2.95 (>2.3). The LV ejection fraction (EF) was 32.6%, and the right ventricular (RV) EF was 32.5%. Moderate global hypokinesia of both ventricles was observed. Mild mitral regurgitation was present. No significant left to right cardiac shunt or late gadolinium enhancement was seen at the LV wall to suggest presence of scar or fibrosis (Fig 2). No abnormal thinning of the wall, focal/regional RV wall motion abnormality, or aneurysmal change was noted. No thrombus was present within the cardiac chambers. A normal configuration of a left-sided aortic arch was observed with absence of coarctation. Subsequent genetic testing for pathogenic mutations for NC was negative in this patient. Ventricular NC of the myocardium, also known as spongiform cardiomyopathy, is a rare cardiomyopathy arising from arrested endomyocardial development during embryogenesis,1 with an incidence of approximately 0.05%.2 Non-compaction is a group of genetically heterogeneous disorders and can be inherited in autosomal dominant, autosomal recessive and X-linked recessive pattern.3 However, the majority of NC have idiopathic pathogenesis, and the diagnostic yield of gene panel testing in LVNC is low (~9%). Patients with isolated NC are less likely to have a positive genetic test result.3 Morphologically, NC is characterised by an altered myocardial wall with resultant prominent trabeculae and deep intertrabecular recesses,4 leading to an abnormal thickened bilayer of compacted and non-compacted myocardium. The LV is more frequently involved and biventricular involvement is less commonly encountered. The absence of wall thinning, RV wall motion abnormality or aneurysmal change, although not diagnostic, suggests an alternative diagnosis to that of arrhythmogenic RV dysplasia. Principal clinical manifestations of NC include: heart failure, arrhythmia, cardioembolic events, syncope, and sudden cardiac death.4 Even though our patient had remained asymptomatic prior to diagnosis, there were notable reductions in LVEF and RVEF, suggesting heart failure. Cardiac magnetic resonance in establishing suspected NC cases would be crucial in: (1) confirming the diagnosis, (2) establishing residual cardiac function, and (3) determining presence of other associated cardiac malformations, such as LV outflow tract abnormalities (eg, bicuspid aortic valve), Ebstein anomaly, tetralogy of Fallot (more commonly diagnosed at a younger age-group) or coarctation of the aorta. Cardiac magnetic resonance is also superior to echocardiography in delineating RV anatomy and function, evaluating RV involvement of NC, determining presence of intracardiac thrombus and myocardial scarring. After the above diagnostic considerations have been addressed, management PICTORIAL MEDICINE


This Paper attempts to reconcile two apparently contradictory trends in the UK labour market over the 1980s and 1990s. While wage differentials based on observed skill have risen for men, wage differentials between men and women have fallen. If women earn less than men because they are less skilled, then one would expect differences across genders to follow the same trends as differences across skills. The simplest explanation of the data is that the labour market has become more competitive, resulting in a fall in discrimination and an increase in the return to skill. As this explanation is not directly and easily testable, this Paper examines its plausibility by assessing other explanations for these results.


abstract:This paper investigates the history of drugs sold as "patent medicines" in India in the early twentieth century. The paper investigates their legitimacy as patenting of medicines was forbidden by the Indian Patents and Designs Act, 1911 (IPDA). The paper argues that the instrument of letters patents functioning as the prerogative of the Crown that gave monopolistic rights to grantees to sell any compound without having to disclose its constituents was the reason behind this seemingly conflicting historical relationship between the law and the market. Colonial law-making left sufficient space within the ambit of the IPDA for letters patents to have their ill effects. The colonial state made attempts to address this as a public health issue by incorporating concerns related to this class of medicines within regulations addressed to the drugs market in the 1930s. The currency of patent medicines in the market was further added to by Indian indigenous entrepreneurs fueled by cultural nationalism of Swadeshi ideology in Bengal in the early twentieth century. However, even such indigenous responses or attempts at hybridization of manufacturing and selling practices related to patent medicines were mostly informed by upper-caste/upper-class interests and not so much by those of consumers of these medicines.


OBJECTIVES: During the treatment of chronic apical periodontitis and pulp necrosis the main role is to irrigate the root canal. AIM: The aim of this in vivo study was to irrigate with 0.9% NaCl (Natrium Chloride), 2.5 % NaOCl (Sodium Hypochlorite Solution, Sigma Aldrich - Germany) and 2% CHX (Chlorhexidine Digluconate Solution, Sigma Aldrich - Spain) combined with Gaseous Ozone (Prozone WH, Austria). MATERIAL AND METHODS: This study was realised in the University Dentistry Clinical Centre of Kosovo (UDCCK), respectively in the Department of Endodontic and Dental Pathology, Dental Branch, Faculty of Medicine, Prishtina, Kosovo. The 40 subjects involved in this study belonged to both genders, in age between 15 -65 years. The sample selection was randomised. The retroalveolar radiography for each patient was taken in the suspected tooth. As a therapeutic plan the authors decided to disinfect the root canal with the irrigants, as follows: 2.5 % NaOCl, 2 % CHX and gaseous ozone. RESULTS: The statistical analyses were based on Kruskal - Vallis test, X - test, DF = 3, r < 0.01. In the isolated average number of the aerobe and anaerobe bacteria colonies, when gaseous ozone was used, there was the significant statistical difference. CONCLUSIONS: When gaseous ozone was combined with irrigants 0.9%, 2.5 % NaOCl and 2% CHX, it was concluded that the number of colonies of aerobic and anaerobic bacteria was reduced.


Using an example from the Unified Modelling Language, we invite submissions to explore the ways in which model transformation languages can be used to update models in response to metamodel changes.


In this paper, we formulate a dynamic theory of economic policy using concepts and axioms of mathematical system theory. First, the notion of a dynamic economic system is characterized axiomatically. Then the basic problem of the theory of economic policy as introduced by Tinbergen and Theil is expressed as a control problem for a dynamic economic system. In this way, a more general framework for the theory of economic policy than available so far can be developed in terms of mathematical system theory. Key-Words: Dynamic system; system theory; control theory; economics; economic policy; modeling.


The utility model discloses an RJ45 modularized separated assembling structure comprising a shell, at least one connecting module and at least one RJ45 module. The front end of the shell is inwardly recessed so that an accommodating space is formed. The shell is installed on a mother board in a machine case. The connecting modules are arranged in the accommodating space. The connecting modules comprise first insulating members and connecting terminals which are arranged on the first insulating members. The connecting terminals are electrically connected with the mother board. The RJ45 modules are inserted in the accommodating space from the front to the back. The RJ45 modules are provided with PCBs. The golden fingers on the PCBs are connected with the contact parts of the connecting terminals in a contacting way. According to the structure, different RJ45 modules can be conveniently replaced in an ethernet multi-port product according to different electrical performance requirements without replacing the whole product and even the whole mother board so that a general mother board is developed by clients, only the RJ45 modules are unplugged and replaced in operation without damage to the mother board, and thus design and maintenance cost is reduced and the period is effectively shortened.


Correlation and stepwise regression analysis on the loss of leaf yields and output value under three main diseases was conducted.The results demonstrated that: under the influence of three main diseases,the loss of leaf yields and output value of nine flue-cured tobacco reached significant and highly significant levels to a certain extent.Especially KRK26,its loss reached 885.00 kg/hm2 and 10 936.05 yuan/hm2.Correlation analysis showed that,the disease index of Granville wilt was significantly positively correlated with the loss of leaf yields and output value.Stepwise regression and path coefficient analysis also demonstrated that the disease index of Granville wilt was the primary factor,the disease index of tobacco weather fleck was the next.The stepwise regression equation were Y1=-7.1448+5.0168X1+5.6355X3(R=0.9554) and Y2=-88.3258+62.0046X1+69.6412X3(R=0.9554).


Chiral oxiranes are converted into chiral aziridines viaβ-hydroxyalkly aryl sulfides and then β-tosylaminoalkyl aryl sulfides without loss of optical purity and with overall retention of configuration.


The dial-a-ride problem with time windows is studied in this article. First, a new efficient mixed integer programming formulation is proposed by merging some of drop-off nodes into paired pick-up nodes when a size of the order forbids ridesharing, so a vehicle must visit the paired drop-off nodes directly after the pick-up, thus reducing the number of decision variables by 40% on benchmark instances. Secondly, three different constraint programming formulations are proposed for the first time, generating efficient schedules within a few seconds. Thirdly, a real-time rescheduling perspective is further studied, since the ridesharing becomes dynamic when a schedule must be provided instantly. In particular, the warm-start search method, in which a precalculated schedule is continuously revised as new orders come in, is proposed.


Abstract –in this paper we improve power quality of transmission system .using statcom and svc and we also comparative analysis of transmission system .one of the major problems of voltage stability is the reactive power limit of the system. Improving the system's reactive power handling capacity via Flexible AC transmission System (FACTS) devices is a solution for prevention of voltage instability. In this paper it is studied the influence of Static Synchronous Compensators (STATCOM) and Static Var Compensators (SVC) in dynamic Voltage Stability The methods for sub synchronous oscillation mitigation based on SVC and STATCOM are analyzed in this paper. According to the IEEE first benchmark model, the electrical damping coefficients respectively provided by SVC and STATCOM connected at the generator terminal, as well as positive damping condition, are deduced by complex torque coefficient approach. Correlative factors which influence the two positive damping are compared. The analysis results indicate that the positive damping provided by SVC is proportional to the size of system voltage. The positive damping provided by STATCOM is not affected by the size of system voltage, which is mostly proportional to the sub synchronous voltage produced itself. The controllers of SVC and STATCOM are designed and the positive damping separately offered by SVC and STATCOM are optimized by phase compensation with test signal method. The time domain simulation reveals that STATCOM has stronger damping ability than SVC in the case of short circuit fault.


The purpose of this study was to identify the relationship between bullying, nursing work environment, reality shock and factors of influence on turnover intension. Data were collected from 381 nurses who were under the charge nurse at a hospital with more than 600 beds in Seoul. The collected data were analyzed using the SPSS24.0 program. The mean score for turnover intension was 3.61 ± 0.89. The intension of turnover was correlated with bullying in the workplace (r=0.197, ρ=.001), the nursing work environment (r=-.409, p=.001), and reality shock (r=.572, p=.001). Variables affecting turnover intension were the work department(β=-0.018, ρ=.049), working environment(β=-0.424, ρ<.000), and reality shock(β=0.654, ρ<.000). The total amount of explanation for turnover intension was 37.3%. The degree of turnover intension of nurses was affected by work in general wards, the experience of workplace bullying and the nursing work environment. To reduce turnover intension, nursing work needs to be analyzed and efforts are needed to establish an effective communication system.


The article describes the device limits the power of wind turbines and the calculations of the parameters of the spring, the wind pressure on the opposing side shovel.


Species of the brachyuran crab genus Hexapanopeus Rathbun, 1898, are common benthic inhabitants in coastal and nearshore waters of the Americas. Despite the frequency with which they are encountered, they are taxonomically problematic and commonly misidentified by non-experts. Little previous work has been undertaken to explain relationships among the 13 nominal species of Hexapanopeus or their relationship to other phenotypically similar genera of the family Panopeidae. In the present study we examine partial sequences for 16S and 12S mitochondrial rDNA for 71 individuals representing 46 species of Panopeidae and related families of the Brachyura. Phylogenies inferred from both of these datasets are largely congruent and show, with one exception, the included genera and species of the Panopeidae to represent a monophyletic grouping. Within this group, Hexapanopeus is polyphyletic, being distributed among several separate major clades and clearly warranting taxonomic subdivision.


Benzoyl peroxide (BPO), a member of small-molecule reactive oxygen species (ROS), has attracted considerable attention because of its impact on human health and industrial importance.


The modern age of technology is trending with digitalization and reshaping the business around the world. Advancement of new technologies and innovations are transforming businesses in numerous ways and creating a whole new business computational ecosystem. Most often professionals are across the globe are talking about terms like digitization, Industry 4.0, Big Data, Block chain Technologies, cloud computing, 3D Printing, Machine Learning, Automation, Artificial Intelligence (AI), Internet of Things (IoT), Data mining etc. Amidst, all the major advanced technologies mentioned above, Cloud Computing, is one of the fast emerging into a large scale computing system with seamless access to virtually limitless resources. Just to apprise how the computing systems works before cloud computing ;technically to elucidate, Server-That was the past, back in the days say 20 years ago every company used to have its own server. In computing, a server is a computer program or a device that provides functionality for other programs or devices. A server is basically a very large computer (just like a mainframe) with its own set of hardware which includes a sophisticated processor capable of handling huge workloads from the office clients. On top of these servers the Operating System (OS) was installed and the applications were placed on these OS. The server will contain all the database of that particular organization and all the concerned in that organization will have access to that data stored in that server through WAN (Wide Area Network) or LAN (Local Area Network). The data stored in these servers can be anything ranging from stock record, records of all transactions or even application or email service. Typical servers are Database servers, CatLog server, File Servers, Print Servers, Sound Server, Media Server, Mail Server, Proxy servers, Web servers, Game Servers, Application servers etc. Hence, to maintain such server facility and proper functionality, it's becoming daunting task for small and big companies too. As such huge investment, technical expertise, IT infrastructure, vendors, manpower, security , licensing, overall maintenance cost shall gradually become untenable. Then come "Revolutionizing Computing systems called 'Cloud computing" which is supposed to be totally changed scenario of computational systems. Since it is cheap, no need to hire professional IT to maintain server, no wastage of money on acquiring server OS licensing, user friendly. Hence, it could be sustained in small and big companies/enterprises easily. Coronavirus, now declared as pandemic, is causing widespread shutdown and chaos. The rapid spread and global impact of COVID-19 can make people feel helpless and scared as the novel coronavirus escalates and forces them to change many aspects of their respective lives. It is clear that the world needs a quick & safe solution right now to combat further spread of coronavirus . What then is the best solution to this health crisis? This is where technologies such as cloud computing, AI & machine learning come into play. It will be very interesting to see how cloud computing will address and contribute towards these issues in the healthcare system & industry. The purpose of this paper is to explore the current state, status and trends of cloud computing in health system in view of covid-19.


This paper explores the relationship between the common Prevent/Mitigate, Prepare, Respond, Recover (PPRR) framework and the Australasian Inter-service Incident Management System (AIIMS) in NSW. The bushfire experience in Australia during 2019–20 revealed the limitations of existing approaches to 3 of the 4 PPRR phases: prevention/mitigation, preparation and recovery. A lack of coordination across agencies, as identified in the Final Report of the NSW Bushfire Inquiry (Owen & O'Kane 2020), reduced the value of much good work. A whole-of-government strategy using AIIMS structures is recommended to promote effective coordination across agencies rather than relying on current collaborative committees that are constrained by agency priorities. AIIMS provides a means of coordinating the work of agencies in prevention/mitigation, preparedness and recovery by working across agencies to enhance the safety of communities.


An apparatus and a method for measuring compression strength according to time of a foam are provided to select the material and density of the foam with less deformation quantity by measuring relative displacement for a lower plate against an upper plate through a linear position sensor and installing a display part. An apparatus for measuring compression strength according to time of a foam comprises a lower plate(10), at least two guide shafts(20), an upper plate(30), and a measuring device part(40). The lower plate receives the foam. The guide shafts are fixed to the lower plate and projected to be perpendicular to the lower plate. The upper plate is placed to be horizontal to the lower plate, and a lower surface of the upper plate is contacted with an upper surface of the foam. The measuring device part measures positions according to the times of the upper plate. The upper plate includes ball bushings(35) assembled with the guide shafts to be moved longitudinally. The measuring device part includes a linear position sensor(42) measuring relative displacement for a lower plate against an upper plate, and a display part(44) calculating a differential value for the relative displacement or for the time of the relative displacement.


This paper discusses how to add rate control to TCP in order to improve performance of multiple concurrent connections competing for bandwidth in a local área network. In such an environment connections started in parallel by a single application (for example, a Web browser or a parallel file system client) tend to compete for bandwidth in spite of their cooperative behavior. Such competition usually leads to poor performance, specially if TCP Reno is involved. In this work we describe how rate control can be added to the TCP/IP stack to reduce such performance losses by breaking up packet trains (one of the problems with TCP Reno) and by allowing connections with a common source to share Information about observed network congestion. The system hás been simulated for a wide range of network scenarios showing performance gains of at least 15 % in most cases, sometimes in excess of 100 %.


Change of peel colour in banana(Musa acuminate L. AAA Cavendish. cv. 'Formosana')fruit during ripening at 25 ℃, 20 ℃ and16 ℃ was investigated. The result showed that the chlorophyll content decreased and carotenoid content increased gradually, and a fully yellow peel was presented, while ethylene release content was a single peak during ripening at 20 ℃ and 16 ℃. However, peels at 25 ℃ leaded to stay-green ripe banana fruit and inhibited chlorophylla degradation and carotenoid synthesis. Moreover, ethylene release content at 25 ℃ was much more than that at 20 ℃ and 16 ℃, respectively. These result suggested that the stay-green peel of banana fruits might mainly involved in the inhibition of chlorophylla degradation at 25 ℃.


MODIS is one of the key instruments for the NASA's EOS mission, currently operated on both Terra and Aqua spacecraft making continuous and complementary observations in 36 spectral bands from 0.4 to 14.2 micrometers. Among them are long-wave infrared (LWIR) bands (11-14.2 micrometers) with Photoconductive (PC) HgCdTe detectors. The Terra MODIS pre-launch thermal vacuum calibration and characterization have shown clear evidence of an optical leak presented by the 11 micron band (band 31) into other PC bands (bands 32-36). A correction algorithm has been designed and implemented in the MODIS Level 1B (L1B) code using coefficients determined from the lunar observations made in year 2000. In this work we evaluate the optical leak correction coefficients derived from Terra MODIS lunar observations from January 2001 to December 2004. Our method assumes that in the absence of an optical leak the detector's signal would decay away from its peak response to the moon as an inverse power series function of the frame offset number. The least Chi-squared minimization method is used to calculate the parameters in the fitting function. Analysis results from the lunar and Earth view observations show that the Terra MODIS PC optical leak has been effectively removed. The Level 1B algorithm has been shown to be stable.


A rare type of pottery, found in four single graves under earthen mounds in the Carnac region of Brittany, consists of a circular, flat-based vessel with a near-vertical wall. On the basis of the equipment known from elsewhere in the world, it is possible that the morphology of these dishes is related to processes involved in the production of salt. To help us in exploring their function, we chose to compare these vessels with another enigmatic class of pottery from the Cyclades – the socalled 'frying pans' – which seems to have functioned in a similar way, as an object-sign, and has been found in a maritime milieu and in high-status contexts.


An examination by leading scholars of what the ancient Greeks had to say on the relation between the universal and the particular in ethics, psychology, metaphysics and cosmology.


South Kalimantan Province is one of the areas of agricultural land suitable for Siamese citrus. But several problems can affect the decline in Siam Banjar citrus production and must be prevented immediately so that production rates remain stable and can continue to increase, one of which is farmers in Indonesia who still depend on the rainy season to grow crops and will experience drought problems during the dry season. Come. That's why, along with the development of current technology, one of which is in the agricultural sector, with the help of Internet of Things (IoT) technology, a tool is made, namely automatic watering using the Fuzzy Logic Control method. There are several advantages when using the help of the Internet of Things (IoT), such as water that will be real-time, comprehensive water intake, and following the state of the plant at that time. It is hoped that with the help of this device, Siamese orange farmers can get better harvests in the future


We propose a molecuar-based device model which has the function of visual information processing of the retina. photosensitive lipid membranes in a porous substrate and an external electric oscillation circuit. Using this model it is clarified that the light information can be reversibly converted into the change of the oscillation frequency through the molecular structure change of the lipids in the membranes. The model device was composed of


A memory device and a display device are provided to build a memory of the multi-bit configuration in a pixel with the small area. A memory device(1) is made of the parallel connection of a magneto-resistance device and a thin film transistor. The thin film transistor(TFT) comprises a semiconductor film and a gate electrode. The semiconductor thin film channel includes an input terminal and an output terminal. The gate electrode overlaps the channel region, and becomes the control part. A ReRAM(Resistance Random Access Memory) comprises one conductive layer which is connected to the input terminal side of the thin film transistor; the other conductive layer which is connected to the output terminal of the thin film transistor; and an oxide layer which is arranged between the conductive layers.


Purpose of this study, which is for women divided into four groups at the level of the primary -school, university, middle aged and elderly, is effectiveness of luminous (RGB-primary) and material (CMY -secondary) color concepts in perception and color preferences of women in various age groups. A survey in two stages has been conducted with women in four different age groups residing in Istanbul. In the first stage, by forming a shade card with six basis colors and by using the tonal differences of 6 primary colors in each card. It is investigated how close they are to primary color concepts in printing and which tones of these colors they perceive mostly.In the second stage, their favorite colors are identified by applying the survey. In result of research, with the data obtained from two -staged survey, it is checked if there is a difference in color perception among age groups. Through these determinations, the color preferences of different age groups and how they can identify primary (RGB) and secondary (CMY) colors that form the base of color and how accurate they perceive them are determined.


The subject matter of the present article is the analysis of reaction to stimulus «Russian». It is of great importance to find out what elements of appearance become the objects of linguistic evaluation and what evaluations dominate.


"Unprotected" Pt nanocrystals were modified with triphenylphosphine (PPh3), octadecylamine (ODA), poly(vinylpyrrolidone) (PVP), poly(vinyl alcohol) (PVA), and dodecanethiol (DT) to investigate the effect of protective agents on the intrinsic catalytic property of Pt nanocrystals. By evaluating the catalytic performance of these model catalysts for the hydrogenation of para‐chloronitrobenzene (p‐CNB), it was found that direct or indirect interaction between nanocrystals and protective agents imposed a great impact on the catalytic performance of the nanocrystals. Protective agents with different electron‐donating ability (PPh3, ODA, PVP, and PVA) directly altered surface electronic state of Pt nanocrystals to bring the surface Pt atoms into an electron‐rich state, which would exert influence on the hydrogenation course by changing the adsorption and the reactivity of reactant, intermediates, and products. In contrast, DT exerted an indirect influence on the Pt nanocrystals. The coordinated Pt atoms were oxidized by DT to generate cationic Pt species on the surface of nanocrystals, and the cationic species would simultaneously improve the hydrogenation rate and selectivity to para‐chloroaniline by polarizing the N=O bond in the −NO2 group of p‐CNB and altering the electronic state of Pt nanocrystals, respectively. This work provided further insights into nanocatalysis, which is helpful for further design and application of highly efficient nanocrystal catalysts.


At times the personal beliefs or values of graduate students in training programs for professional psychology can create complications in their providing therapy for certain patient populations. This issue has been brought to national attention recently through several prominent legal cases in which students have contested their expulsion from graduate programs due to their assertions that they were unable to treat clients in same-sex relationships because of their own religious beliefs. The goals of the current article are to (a) review the literature on values conflicts, (b) provide an analysis of how portions of our professional Ethics Code directly relate to this issue, (c) describe a developmentally sensitive theoretical framework that is designed to foster the growth of ethical reasoning over time, and (d) provide a forum for trainee perspectives on this issue based on trainees' responses to an ethical vignette describing an intern struggling with a values conflict. The trainee quotations are used to structure a discussion of practical recommendations for how to handle values conflicts within the context of training and clinical supervision in professional psychology.


NING LU and WILLIAM J. LIKOS. John Wiley and Sons Inc, Hoboken, New Jersey. 2004. Hardcover, 556 pp. $130. ISBN 0-471-44731-5.

Unsaturated soil mechanics is a relatively new discipline developed during the past 40 years from classical soil mechanics, which deals with stress, strength, and


ICAR Research Complex for NEH Region, Umiam-793103, Meghalaya, IndiaBlack-eyed Susan (Rudbeckia hirta) (Asteraceae) has yellow flowers withpurplish black, raised central discs. Flowers from this genus are oftencalled coneflowers.It is commonly used forornamental purposesinIndiaandgrowncommerciallyinhillstateslikeHimachalPradesh,Meghalaya,Sikkim and others. During July 2008, plants of R. hirta from Shillong,Meghalaya (Northeast India) and nearby areas were found to be infectedwith powdery mildew. Dense white circular to irregular mycelial patcheswere present on both surfaces of the leaves. Symptoms were also presenton stem and flowers. Older leaves were found to be more susceptible.More than 50% of the plants selected randomly from ten localities wereinfected.Powdery mildew belonging to the genera Golovinomyces, Podosph-aera (=Sphaerotheca) and Phyllactinia have previously been reported onRudbeckia from United States, Sweden, Germany, Canada, Korea,Switzerland, Italy and Japan (Farr et al., 2005). Presence of ectophyticmycelium with nipple shaped appressoria and conidia without fibrosinbodies excluded the possibility of Phyllactinia and Podosphaera butsuggested Golovinomyces. Conidiophores contained a cylindrical footcell (33–68 · 8–13 lm) followed by two to three short cells. Conidiawere mostly cylindrical, a few doliiform (27–36 · 11–18 lm). Thepathogen was identified as the anamorph of Golovinomyces cichoracea-rum (Cook & Braun, 2009), which was further confirmed by thegermination pattern (terminal with moderately long germtubes andswollen appressorium). A recent report by Garibaldi et al. (2008) refersto the presence of G. cichoracearum on Rudbeckia spp. from India.However, subsequent analysis of conidial dimensions and germinationpattern shows that the reported pathogen belongs to a different species,namely G. ambrosiae (syn. G. cichoracearum var. latisporus) (Cook &Braun, 2009).Pathogenicity was confirmed by dusting conidia on healthy pottedplants of R. hirta, non-inoculated plants serving as control. Inoculatedplantsdevelopedtheoriginalpowderymildewsymptomsafter8–10 dayswhereas control plants remained healthy. Voucher specimens (HAL2290 F.) were deposited at Martin-Luther-Universita¨t, Institut fu¨r Biolo-gie, Bereich Geobotanik, Herbarium, Germany and Institute Herbarium(ICARHNEH-26) ICAR Research Complex for NEH Region, Megha-laya, India. The pathogen has not been reported from the neighbouringcountries such as Pakistan, Sri Lanka, Bangladesh so it may have beenintroduced to India by imported material. This is the first record of pow-derymildewofR.hirtacausedbyG.cichoracearuminIndia.AcknowledgementsThe authors wish to thank Dr. Uwe Braun for his comments onG. cichoracearum var. latisporus and Dr. RTA Cook for kindly provid-ing the literature.References


Practice teaching has an unsubstitutable function in embodying the feature of applied oriented undergraduate institute.While the applied institute must give answers to a series of questions about practice teaching role,practice teaching goal,practice teaching form,practice teaching content,practice teaching approach and its evaluation system,so as to construct the particular teaching system of applied oriented undergraduate institute.


In developing countries, room-level air conditioners (air-cons) are a major consumer of electricity across residential and small-scale commercial buildings. In these air-cons, the user specifies their comfort requirements on an inbuilt thermostat through infrared (IR) based remotes. State-of-the-art thermostats emulate the AC remotes and assist occupants in remotely changing the thermostat temperature, through their smartphones. The room-level control together with buildings' poor thermal insulation makes air-cons an attractive target for energy conservation. In this work, we explore grey-box modeling techniques to upgrade the commercial thermostats for - 1. actionable feedback, 2. energy-efficient control, and 3. corrective feedback. We plan to address these three core issues and develop portable and ubiquitous thermostats that leverage easy-to-collect ambient information to optimise the AC operations while ensuring the user comfort. The aim of this work is to achieve comfortable energy-savings for the users with minimal interference from the sensors.


This paper describes the occurrence of kernicterus and factors which influence its development in the strain of rats * first studied by Gunn. 22,23 The disease of humans designated in 1903 by Schmorl 39 as kernicterus has, in our opinion, not been observed or induced in its entirety in animals. Various workers, however, have demonstrated the toxicity of indirect bilirubin. 12-15,24,26,44-46 Ernster, Herlin, and Zetterstrom 21 have caused localized pigmentation of the brain of the rabbit by treatment with bilirubin and an S-H blocking agent. Other workers 17,19,20 have reported injury of brain tissue in hemolytic anemia of animals, a phenomenon not directly related to the present report, since the rats to be described do not suffer from antibody-antigen disease and have little or no hemolytic Definition of Kernicterus The following criteria are proposed as defining kernicterus: Distinctive evidence of central nervous system dysfunction during life in jaundiced subjects Canary yellow


This article provides a survey of some of the reasons why computational approaches have become a permanent addition to the set of scientific methods. The reasons for this require us to represent the relation between theories and their applications in a different way than do the traditional logical accounts extant in the philosophical literature. A working definition of computer simulations is provided and some properties of simulations are explored by considering an example from quantum chemistry.


Axicabtagene ciloleucel (Axi-cel) is an autologous anti-CD19 chimeric antigen receptor (CAR) T-cell therapy approved for the treatment of relapsed or refractory diffuse large B-cell lymphoma (r/r DLBCL). Long-term analysis of the ZUMA-1 phase 1-2 clinical trial showed that ~40% of Axi-cel patients remained progression-free at 2 years (Locke et al., Lancet Oncology 2019). Those patients who achieved a complete response (CR) at 6 months generally remained progression-free long-term. The biological basis for achieving a durable CR in patients receiving Axi-cel remains poorly understood.
 Here, we sought to identify CAR T-cell intrinsic features associated with CR at 6 months in DLBCL patients receiving commercial Axi-cel at our institution. Using mass cytometry, we assessed expression of 33 surface or intracellular proteins relevant to T-cell function on blood collected before CAR T cell infusion, on day 7 (peak expansion), and on day 21 (late expansion) post-infusion. To identify cell features that distinguish patients with durable CR (n = 11) from those who developed progressive disease (PD, n = 14) by 6 months following Axi-cel infusion, we performed differential abundance analysis of multiparametric protein expression on CAR T cells. This unsupervised analysis identified populations on day 7 associated with persistent CR or PD at 6 months. Using 10-fold cross-validation, we next fitted a least absolute shrinkage and selection operator (lasso) model that identified two clusters of CD4+ CAR T cells on day 7 as potentially predictive of clinical outcome. The first cluster identified by our model was associated with CR at 6 months and had high expression of CD45RO, CD57, PD1, and T-bet transcription factor. Analysis of protein co-expression in this cluster enabled us to define a simple gating scheme based on high expression of CD57 and T-bet, which captured a population of CD4+ CAR T cells on day 7 with greater expansion in patients experiencing a durable CR (mean±s.e.m. CR: 26.13%±2.59%, PD: 10.99%±2.53%, P = 0.0014). In contrast, the second cluster was associated with PD at 6 months and had high expression of CD25, TIGIT, and Helios transcription factor with no CD57. A CD57-negative Helios-positive gate captured a population of CD4+ CAR T cells was enriched on day 7 in patients who experienced progression (CR: 9.75%±2.70%, PD: 20.93%±3.70%, P = 0.016). Co-expression of CD4, CD25, and Helios on these CAR T cells highlights their similarity to regulatory T cells, which could provide a basis for their detrimental effects.
 In this exploratory analysis of 25 patients treated with Axi-cel, we identified two populations of CD4+ CAR T cells on day 7 that were highly associated with clinical outcome at 6 months. Ongoing analyses are underway to fully characterize this dataset, to explore the biological activity of the populations identified, and to assess the presence of other populations that may be associated with CAR-T expansion or neurotoxicity. This work demonstrates how multidimensional correlative studies can enhance our understanding of CAR T-cell biology and uncover populations associated with clinical outcome in CAR T cell therapies.
 This work was supported by the Parker Institute for Cancer Immunotherapy.
 Figure

 Muffly: Pfizer: Consultancy; Adaptive: Research Funding; KITE: Consultancy. Miklos:Celgene: Membership on an entity's Board of Directors or advisory committees; BMS: Membership on an entity's Board of Directors or advisory committees; Kite-Gilead: Membership on an entity's Board of Directors or advisory committees, Research Funding; AlloGene: Membership on an entity's Board of Directors or advisory committees; Precision Bioscience: Membership on an entity's Board of Directors or advisory committees; Miltenyi Biotech: Membership on an entity's Board of Directors or advisory committees; Becton Dickinson: Research Funding; Adaptive Biotechnologies: Membership on an entity's Board of Directors or advisory committees; Novartis: Membership on an entity's Board of Directors or advisory committees, Research Funding; Juno: Membership on an entity's Board of Directors or advisory committees. Mackall:Vor: Other: Scientific Advisory Board; Roche: Other: Scientific Advisory Board; Adaptimmune LLC: Other: Scientific Advisory Board; Glaxo-Smith-Kline: Other: Scientific Advisory Board; Allogene: Equity Ownership, Membership on an entity's Board of Directors or advisory committees; Apricity Health: Equity Ownership, Membership on an entity's Board of Directors or advisory committees; Unum Therapeutics: Equity Ownership, Membership on an entity's Board of Directors or advisory committees; Obsidian: Research Funding; Lyell: Consultancy, Equity Ownership, Other: Founder, Research Funding; Nektar: Other: Scientific Advisory Board; PACT: Other: Scientific Advisory Board; Bryologyx: Other: Scientific Advisory Board.


Soon after the devastating, 7.2 magnitude temblor of the "Great Hanshin Earthquake Disaster" hit the Kobe, Japan area at 5:46 A.M. on January 17, 1995, Mayumi Morimoto, professor of Cross-cultural Studies at Kobe University, escaped through the window of her crumbled Ashiya condominium complex with only her Macintosh Powerbook 160/14/80 in her backpack. Across town, Virginia Garland, Visiting Professor of English and American Studies at Kobe University, along with her husband and two cats, evacuated their damaged high rise apartment building. They watched news of the disaster on CNN on a Sony Watchman television set in a nearby elementary school shelter. Professors Morimoto and Garland were initially unaware that the pre-dawn earthquake would claim more than 5,400 lives, including 249 foreigners, and that they were among 300,000 people who had instantly become homeless during the 40 seconds which shook them and their apartments in the greatest vertical tremors from an earthquake ever recorded. The two faculty colleagues had both become survivors and evacuees. However, they found that the latest telecommunications technologies from japan and the United States were effective tools in dealing with this tragedy in the hours and days which followed. * Infrastructure Interrupted Several communications-related issues were evident on the day of the quake, when it became increasingly apparent that the cities of Kobe, Ashiya and Nishinomiya were isolated from the rest of Japan. Radio and TV broadcasts indicated that raging fires and continuous aftershocks were contributing to the destruction. Telephone contact within the devastated Hyogo area was impossible, but phone communication was possible to other prefectures in Japan and to foreign countries. Transportation was also cut off, due to the unprecedented collapse of major highways and railroad lines. Professors Garland and Morimoto both lived in Ashiya, one of the hardest hit areas. Separated by the severed Hanshin, JR and Hankyu railways and the horrifically overturned Hanshin Expressway, the two friends were unable to contact each other until January 18, through emergency phone lines belatedly set up by the Japanese Self Defense Forces (SDF) at the school shelter to which Garland and her family had evacuated. It was clear that the people in the quake-stricken cities had to re-establish contact with friends, relatives, colleagues, employers and students as well as with disaster relief and embassy personnel in the national and international community as soon as possible. At Kobe University, two staff and 39 students (including seven international students) from the 14,000-strong student body perished in the quake. All of the laboratory animals in the Biology Department at the Faculty of Science died of cold and starvation. Faculty members, especially in the downtown Kobe University School of Medicine, lost vital research data and samples. Many faculty, staff and students were injured and lost their homes. Over 1,100 people in Kobe's destroyed Nada ward took shelter in the university's gymnasium. Physical damage was minimal at the Rokko mountain campus but use of the Internet was temporarily halted with a power outage. Computers on rolling carts and heavy weight computers on tables were generally undamaged; but other computers were destroyed by falling furniture, particularly bookcases. Normal telephone and fax communications were cut off. * Can't Stop the Net Masao Tanaka, Dean of the Faculty of Cross-Cultural Studies, bravely managed to get to his Kobe office from his Osaka home on January 17 and promptly implemented emergency government telephone lines. Tanaka first contacted all parents of the 280 Cross-cultural Studies majors, then he determined the status of his faculty colleagues and staff members. The dean's office continued to operate by phone, fax and computer on a 24 hours-per-day basis for several weeks after the earthquake. …


Hyaluronan (HA) is an extracellular matrix glycosaminoglycan, with important roles in chronic inflammation, cancer and autoimmunity. 4-methylumbelliferone (4-MU), a small molecule inhibitor of HA synthases, is widely used to study HAs interactions with the surrounding tissues and the immune cells. There is substantial experimental and therapeutic interest in using oral 4-MU to inhibit HA synthesis, but pharmacokinetic and pharmacodynamic data on treatment routes have been lacking. Moreover, it recently became clear that the main metabolite of 4-MU, 4-methlyumbelliferyl glucuronide (4-MUG), is bioactive. We therefore sought to define the pharmacokinetics and pharmacodynamics of 4-MU and its active metabolite 4-MUG in mice. Single dose mouse studies showed that 4-MU administered intravenously (i.v.) resulted in 100-fold higher 4-MU exposure compared to oral (p.o.) administration. The 4-MU ratio AUC i.v./AUC p.o. was 96/1. 4-MUG exposures were much higher than 4-MU exposures after both 4-MU i.v. and p.o. administration, but only small differences in 4-MUG exposure were seen after 4-MU i.v. versus p.o. administration. The 4-MUG metabolite was also administered as a single dose both i.v. and p.o. and showed a 25.9% bioavailability. Compared to 4-MUG p.o. dosing, 1.14 higher 4-MUG exposures were seen after 4-MU p.o. dosing. 4-MU exposure after 4-MUG p.o. administration was minimal but similar to 4-MU exposure after 4-MU p.o. administration. In mice treated for several weeks with 4-MU in chow, the 4-MU concentration immediately drops after treatment was stopped, whereas the 4-MUG concentration showed a peak 1 hour after treatment stop. In a build-up study, 4-MU and 4-MUG treatment in mice lead to a plateau of 4-MU concentration starting at 4 days post treatment start. These 4-MU and 4-MUG concentration findings in vivo will inform future clinical studies and experimental work with 4-MU.


Money laundering refers to the illegal process of disguising the origins of money obtained through criminal activities, and one common method used is known as "money muling." A money mule is an individual who receives money into their bank account from a third party, and then transfers it to another person in cash or other currencies, in exchange for a commission. Money mules operate covertly, concealing their identities as funds are transferred globally. Unfortunately, ordinary individuals can fall victim to scams and lose their hard-earned money through this process. India is also witnessing a rise in money laundering cases, and the Government of India has taken measures to combat this issue. This paper explores the various techniques employed in money laundering, including the use of technology. It also highlights early warning signs to recognize and steps to protect oneself from being unwittingly involved in such illegal activities.


A chair assembly is provided to achieve multistage tilting, free tilting and tilting lock at the same time through a tilting limit function and a tilting locking function. A chair assembly includes a tilting limit mechanism, which comprises: a pair of long holes(8,9) formed at both sides of the rear end of a lower case; an axial rod(10) coupled to the long holes; a spring support mechanism(11); a combining parts(14,15) with which a pair of springs(12,13) are combined; a protrusion(16) between the combining parts; an axial bar inserted into a joining hole of the protrusion and connected to a next piece; a spring holder(21) into which the axial bar is loosely inserted; support; and an elastic control level for controlling elastic force.


At the spallation neutron source of Japanese Proton Accelerator Research Complex (J-PARC), proton beam with a high power such as 1 MW is induced to the target consisted of mercury. Due to reduce the damage, reduction of the peak current density on the target is a crucial for a constant beam operation. Therefore, a nonlinear beam optics with octupole magnets has been developed. It was found that calculated beam profile with the excitation of octupole magnets was in good agreement with the experimental result for 1 MW beam. By using nonlinear beam focus, a considerable flat distribution can be obtained with moderate beam loss at following downstream. The peak current density on the target can be reduced as much as 30 %, which may realize the beam operation with 1 MW.


The purpose of the research was to determine what learning strategies are used by the students of the Señor de Sipán University, during the first academic cycles, to achieve an excellent professional training, since each student is from a different reality: school, geographic area, age , sex, cultural level, among others. To carry out this research, a survey was applied to 163 students of the first academic cycle, from the different faculties of this higher house of studies. It is concluded that the most used learning strategies are support, representing 62.84%, organization, 47.1%, control, 33.22%, and 28.22%, showing that students in the first cycles present mechanical strategies and poor analysis cognitive.


Recent observations on concrete pavements have led to a keen awareness of the role of water in pavements. Present pavement design techniques aim at eliminating as efficiently as possible the water that has infiltrated into the roadbase despite all precautions taken to prevent this infiltration. In the case of existing pavements, the experiment described here, which deals with the mechanical and hydraulic behaviour of a pavement after installation of an experimental drainage device (which was instrumented with a view to obtaining specific measurements) shows that: (1) the a-posteriori installation of the drainage device in a worn, highly-trafficked road with a locally eroded foundation accelerates the deterioration process; (2) the quantity of water collected by a drainage system is very large, especially when the joints are not impervious any more; (3) the water drained internally carries large quantities of fine particles, especially when rain first starts, and this partly explains the deterioration of the pavement. (TRRL)


This thesis deals with the housing characteristics and price constitution.And the housing supply and demand and the reasons for sharp increase of housing price are deeply analyzed.Some reasonable suggestions are made.


National Science education reform initiatives stress the need for steering away from the traditional teacher-centered mode of instruction. This study is part of a three-year project 'Chain Reaction', funded by the European Commission, investigating the approaches of a sustainable Inquiry Based Science Education (IBSE) framework across twelve partner countries. The purpose of this paper is to provide information on how this innovative project was integrated in five Greek Secondary Schools, and to explore the perceptions of all stakeholders: management, teacher educators, teachers and students. Five schools, ten teachers, and one hundred and fifty students aged 14-16 took part in this study. Quantitative and qualitative methods were employed to identify all stakeholders' views. Based on this analysis, it is suggested that as long as this project is tailored to each partner's individual cultural and curricular needs, all stakeholders had a positive experience, which constitutes IBSE as an optimal learning mode with positive contribution to the educational process.


The study was carried out to gather and identify medicinal plants their curative effects and the part of them which is used from the reservation area of Miankaleh. The region under study has an area of 68800 hectares situated 12 kilometers north of the city of Behshahr and northwest of the city of Gorgan. Results obtained showed that out of a total of 43 families, 125 genera, and 155 species found in the region, 33 families, 52 genera and 61 species (39% of all the species) belonged to medicinal plants, among which the class Asteraceae with 6 species and the class Chenopodiaceae with 5 species had the most medicinal species. The most used parts of the plants were the leaves with 31%, the whole plants with 19%, and the roots with 15%. Keywords—Boispherical Reservation Area, Medicinal Plants, Miankaleh, Traditional medicine


The Darwin field model addresses an approximation to Maxwell's equations where radiation effects are neglected. It allows to describe general quasistatic electromagnetic field phenomena including inductive, resistive and capacitive effects. A Darwin formulation based on the Darwin-Ampere equation and the implicitly included Darwin-continuity equation yields a non-symmetric and ill-conditioned algebraic systems of equations received from applying a geometric spatial discretization scheme and the implicit backward differentiation time integration method. A two-step solution scheme is presented where the underlying block-Gauss-Seidel method is shown to change the initially chosen gauge condition and the resulting scheme only requires to solve a weakly coupled electro-quasistatic and a magneto-quasistatic discrete field formulation consecutively in each time step. Results of numerical test problems validate the chosen approach.


Lung cancer is one of the most common malignancies and also the cancer with the highest mortality rate. Among them, non-small cell lung cancer (NSCLC) accounts for 86% of the...


INTRODUCTION
The prevalence of intrauterine growth restriction is 4-5000/100,000 births, and they give the majority of perinatal morbidity.

AIM
The aim of the authors was to compare the pathomorphologic data and vasoreactivity of umbilical vessels and placenta of small for date newborns to that of the normal pregnancies.

METHOD
Samples of the umbilical cord and placenta were divided into case and control groups. Two 10 cm long segments were cut of the umbilical cord at placental insertion. Tissue bath experiment was performed on umbilical vessels and pathomorphologic data were collected according to the Royal College of Pathologists' protocol.

RESULTS
After the development of basal tone, oxytocin and desmopressin did not enhance the vascular contraction, but the pathomorphological and ultrasonographic data were significantly different in the two groups.

CONCLUSIONS
The results indicate that umbilical vessels might not have oxytocin or vasopressin receptors. The pathomorphologic and flowmetric differences could be the causes of small birth weight.


Our brain is an interpreter, probably the most powerful ever conceived by Nature. However, just like every interpreter, it is limited and sometimes it can get things wrong. Most of us take it for granted that what we touch, hear, see, taste and smell is "reality". But this reality is an illusion, a construct, which only exists in our brain, that is, a mental representation. Indeed, what if we could perceive infrared radiations like Cobras or Predator? What if we could see in very low light like cats? What if we could smell people and foods hidden from view 500 yards away? Surely "reality" would feel much different to us if our sensors and brain were able to extract and process such information from the external world. Even more puzzling is the fact that our senses can betray us completely. This is what happens when we see things that are not there or, on the contrary, when we do not see things that are before our eyes. During this lecture, I will attempt to show how the world in embodied in our brain by looking at examples of interactive visual illusions, by showing the power of attention in defining what we see in the world around us, and by introducing patients with brain lesions or mental illness who perceive the world differently.


: This paper analyses an excerpt from an interview with a Venezuelan refugee who lives with her family in a shelter in Boa Vista - Roraima. The analysis of discursive strategies and resources used by her in the meeting set up a game of light and shadow. In this game, she projects the other (her husband, who is absent from the interaction) in the spotlight as an agent who refracts the stereotype of a refugee, while she herself is relegated to the shadows.


In this paper, an intelligent control using Mamdani type PI-Like Interval Type-2 Fuzzy Logic Controller based Social Spider Optimization (SSO) algorithm (IT2PIFLC-SSO) is designed. This controller is used to control a binary trays distillation column. Two models of SIMO and MIMO are used. Gains of the controllers are tuned using SSO algorithm where the reflex flow rate and vapor flow rate are manipulated as variables to reach maximum purity for overhead product and minimum impurity for bottom product with minimum overshoot, minimum settling time and minimum error. The controlled signal is the molar fraction of distillate and bottom. Integral Time Absolute Error (ITAE) is employed as an objective function to measure the improvement in time.Simulation results have shown that the proposed IT2FLC-SSO works efficiently with no disturbance and with the effect of disturbance.


Cheddar cheese was manufactured by inoculation with and without cultures of homofermentative Lactobacillus strains (L. casei-subsp-casei, L. casei-subsp-pseudoptantarum, L. plantarum). Growth rate of microflora, the incidence of heterofermentative lactobacilli and the rate of proteolysis were then studied during aging. The total number of psychotrophs, mesophiles and lactic streptococci reached a maximum at 5 months but maximum numbers attained were dependent upon the curing temperature (7°C or 15°C). The acceleration of cheese ripening by Lactobacillus cultures was accompanied by a greater degree of protein hydrolysis which was detectable after 8 months aging as soluble nitrogen in TCA extracts (360 mg/100g at 15°C and 240 mg at 7°C, versus 170 mg and 75 mg, respectively, for the controls).


The main objectives of this study are twofold. The first objective is to examine the volatility spillover between seventeen European stock market returns and exchange rate, over the period 2007-2011, in a multivariate setting, using the VAR (1)-GARCH (1,1) model which allows for transmission in returns and volatility. The second is to investigate the dependence structure and to test the degree of the dependence between financial returns using two measures of dependence: correlations and copula functions. Five candidates, the Gaussian, the Student's t, the Frank, the Clayton and the Gumbel copulas, are compared. Our empirical results for the first objective suggest that past own volatilities matter more than past shocks (news) and there are moderate cross market volatility transmission and shocks between the markets. Moreover, the result on the second objective implies that, considering all the financial returns together, the Student-t copula seems the best fitting model, followed by the Normal copula, both for the two sub-period. The dependence structure is symmetric and has non-zero tail dependence. However, if we examine the relationship between each pair of stock-FX returns, both of the degree of the dependence and the dependence structure vary when the financial Greek crisis occurs. Our findings have important implications for global investment risk management by taking into account joint tail risk.


Since the development of the digital technologies, the social networkings have efficiently disseminated representations about different social objects and features. Based on this, we analyze the social representation of teacher occupation that is shared on the Facebook fan pages called "Professor da Depressao" and "Profissao Professor". With the support of the theory of social representations (MOSCOVICI, 1978; JODELET, 1989; 2001), we selected images posted on those fan pages, focusing especially on their likes, comments and shares about the teacher occupation. After being classified by viewpoints about the teacher occupation, we used the analysis of content (BARDIN, 1977) to explore the symbolic elements in the comments related to those images. The data show the teacher like a "slave of the job", since the society thinks of teachers as people who work exhaustedly, earn less than they deserve, and, because of this, they are seen as oppressed and socially unsuccessful subjects.


We propose a fully automated novel workflow for lipidomics based on flow injection-followed by liquid chromatography high resolution mass spectrometry (FI/LC-HRMS). The workflow combined in-depth characterization of the lipidome achieved via reversed phase LC-HRMS with absolute quantification as obtained by a high number of lipid species-specific- and/or retention time (RT) matched/class-specific calibrants. The lipidome of 13C labelled yeast (LILY) provided a cost efficient, large panel of internal standards covering triacylglycerols (TG), steryl esters (SE), free fatty acids (FA), diacylglycerols (DG), sterols (ST), ceramides (Cer), hexosyl ceramides (HexCer), phosphatidylglycerols (PG), phosphatidylethanolamines (PE), phosphatidic acids (PA), cardiolipins (CL), phosphatidylinositols (PI), phosphatidylserines (PS), phosphatidylcholines (PC), lysophosphatidylcholines (LPC) and lysophosphatidylethanolamines (LPE). In order to exploit the full potential of isotopically enriched biomass, LILY was absolutely quantified on demand via reversed isotope dilution analysis using FI-HRMS. Subsequent LC-HRMS analysis integrated different calibration strategies including lipid species-specific standards for >90 lipids. Extensive measures on quality control allowed to rank the calibration strategies and to automatically selected the calibration strategy of highest metrological order for the respective lipid species. Overall, the workflow enabled a streamlined analysis pipeline (identification and quantification in separate analytical runs) and provided validation tools together with absolute concentration values for >350 lipids in human plasma on a species level with an analytical run-time of less than 25 min per sample. TOC