Background: Rituximab (RTX) is anti-CD20 monoclonal antibody, registered for the treatment of rheumatoid arthritis (RA). It has been used in clinical practice "of label" in various other conditions including systemic autoimmune diseases – systemic lupus erythematosus (SLE), systemic scleroderma (SScl), Sjögren's syndrome (SjS), polymyositis (PM) and dermatomyositis (DM) and ANCA associated vasculitides, but the results of clinical studies are inconherent. Nevertheless, RTX is frequently used in patients with severe forms of systemic autoimmune diseases with organ involvement after failure of conventional immunosupressive treatment. In Czech Republic, RTX may be used "of label" upon a special request in these special cases. Objectives: To evaluate indications, clinical characteristics, general efficacy, safety and the impact of RTX therapy in patients with systemic autoimmune diseases treated in the Institute of Rheumatology, Prague since 2009 (a retrospective study). Methods: The medical reports of all patients treated with RTX for other diagnosis than RA were analyzed and the clinical data (diagnosis, previous treatment with glucocorticosteroids and immunosuppressive drugs, number of RTX infusion, side effects and global evaluation of the efficacy by physician) were collected and analyzed. Results: In the years 2009 – 2018, 50 patients with various systemic autoimmune diseases were treated with RTX in our clinic (SLE: n=8, SjS: n=2, SScl: n=16, PM: n=6, DM: n=3, MCTD: = 1, ANCA associated vasculitides: n=11, overlap syndromes: n=3). Mean age of the group was 48,12 ±12,9 years at the first RTX treatment and all of the patients experienced previous failure of treatment with 1-6 immunosuppressants. The total number of RTX infusions was 208 with mean 5,32 applications per patient. We have followed the patients for 37,1 months (mean), ranging from 2-114 months. During the follow-up two patients died due to complications of the disease, two patients were lost from the follow-up. The treatment was effective in majority of patients (n=27) and global efficacy was evaluated as "excellent" in 2, "very good" in 10 and "good" in 15 patients. In seven patients the treatment had no effect and in 4 patients the effect could not be evaluated due to short time follow-up. The treatment was well tolerated by patients and we have experienced 39 moderate or severe infections (requiring antibiotics or hospitalization) mostly in patients with ANCA associated vasculitides. In several patients, mild decrease of IgG levels following the RTX treatment was observed but only in one patient required a subsequent substitution with immunoglobulines. We have not observed any malignancy in the group. The detailed characteristics and results of the patients by diagnosis are provided. Conclusion: Rixuximab may be beneficial in some patients with severe forms of systemic autoimmune diseases refractory to the standard immunosuppressive therapy. The treatment is generally well tolerated and the infections are the most common side effect. Acknowledgement: This study was supported by the Research Project No. 0002372801 of the Czech Ministry of Health. Disclosure of Interests: None declared


The aim of this study is to assess the value of P-wave morphology markers in sinus rhythm to predict the imminence of atrial fibrillation (AF) episodes in patients with paroxysmal AF (PxAF). P-wave signal-to-noise ratio (SNR) is emphasized by signal processing methods based on principal component (PCA) and periodic component (πCA), together with time averaging analysis. The P-wave morphology features considered are: total power, relative power components, power at high frequency bands (as a measure of rugosity) and P-wave duration. Features are evaluated at three different five-minute time intervals before AF episode occurrences (at 5 minutes, 30 minutes and 60 minutes before the episode onset) in PxAF patients. Results show that in PxAF patients the relative power of the second-to-first principal component increases and the mean duration of the first principal and periodic P-wave component also increases when the time interval gets closer to the AF episode onset. No significant differences were observed in P-wave rugosity by none of both methods. These findings can be interpreted as P wave becoming more complex and wider at the imminence of AF episodes.


When arguments are repeated in a procedure call, aliasing arises and plays havoc with specification and reasoning. To prevent this aliasing, which renders the semantics of a language unclean even when all other sources of aliasing are avoided, we propose a simple new scheme for parameter passing that uses initial values for passing second and subsequent repeated arguments and localizes the effects of calls.


Hisham Nazer, chairman of the Nazer Group of Saudi Arabia, former minister of planning, former minister of petroleum, and chairman of Saudi Aramco, has written a powerful and provocative book. In this highly original tour de force, Nazer analyzes the deleterious effects of the technological globalization of information on the cultural integrity of Third World nations and sets forth a strategy of resistance for the developing world. The work is directed at intellectuals in these countries, whom he challenges to "not just exist in this world; [but to] create our own world." Rejecting the narrow definition of culture as "object-focused" acts and artifacts, he argues that culture should be understood as "the collective and dynamically active perspectives of living individuals."


Social media is a platform that provides information about every aspect of a person's life. By checking up on someone's social media handle, users can learn about their emotions, feelings, and mood. As a result, in this work, researchers can analyze social media data and model people's emotions and moods. There are two main parts in this framework. The first ensemble classifier scheme is a machine learning tool used to recognize emotional content in data uploaded by users to social media. The second method is a graph-based in which emotional topics are plotted on a graph against people's emotions based on data obtained from a social media platform.


Background: Educational achievement testing is a challenging area of medical education. The purpose of the medical education is mainly to generate excellent medical physicians. There is several diverse systems of medical education in the world. We do not know which system is the best for training of medical students. It is a big issue in Sudanese medical schools to seek for the most effective medical education system. Objectives: To analyze how medical education is carried out in medical schools by testing the recall knowledge of the basic sciences after graduation. Material and Methods: We tested the recall knowledge of anatomy among interns after graduation from our different medical schools that implemented different medical education systems using a self-administered questionnaire consisted of 10 single best answer questions validated by anatomists and surgeons from 3 different universities adopting different types of curricula. Results: A 365 interns within different training specialties were included for the final assessment. The anatomy was considered a difficult subject by 67.1%, and 67.7% were scored 5-7.The system adopted by participants' school of graduation, number and discipline of the rotation when participating in the study, whether preparing for specialty exam or not, showed high significant correlation with the score attained on answering the basic anatomy questions, (P 0.05). Conclusion: Interns graduated from schools adopting integrated system or Hybrid system scores better than those graduated from schools adopting the conventional medical system. Keywords: Anatomy; Medical education; Integrated (Problem-based); Conventional instructional (Discipline-based); Hybrid (Combination)


Information Delivery Service(IDS) is an important part of Information Grid and with the expansion of network and users, Quality of Service(QoS) has been the basic requirement of IDS. The architecture of Content Delivery Network, the frame of Data Delivery Service and the property of Battle Formation(BF) are firstly analyzed and a battlefield information delivery model is put forward based on BF, which also provides the mechanism for information submitting, searching and receiving. Besides this, a delivery method based on information type and a strategy to process information with priority are present, which are paid more attentions on battlefield, and the analysis on it is also provided, theoretical analysis and simulation verify the effectiveness of the methods proposed.


Current data mining procedures utilize operating cycles that encompass selection of the input data learning subset, filtering, application of the chosen mining algorithm, presentation of the output knowledge, and evaluation of the system performance on the unseen test data subset. However, a single pass through the above phases cannot achieve an appreciable result. We introduce an architecture that envelops a collection of semiautonomous multiple procedures (agents) coupled and coordinated through the common blackboard data repository. The architecture includes an efficient performance evaluation tool that assists in tuning systems parameters during multiresolutional construction of diverse elicited models. The presented compositional architecture is application specific and oriented towards probabilistic knowledge discovery.


Olfactometer was used to find the attractiveness of kairomone extracted from gypsy moth (Lymantria dispar) to the egg parasitoid (Ooencyrtus kuvanae). The attractiveness of kairomone extracted from scales and hairs which were attached to the surface of the eggs were higher than that of whole eggs with 79.9% and 67.6% respectively. The probing lantency of the egg parasitoid on the extract of scales and hairs were 115.5 sec. and that of whole eggs were 113.2 sec. Eggs taken from egg mass were shown 91.0% of attractiveness to the egg parasitoid, however only 15% of egg parasitoid were attracted by follicles dissected from the host ovary. The probing latency of egg mass was faster than that of follicles dissected from the host with 84.2 sec. and 114.0 sec. respectively. Egg parasitoid showed the most active attractiveness (88.0%), relatively longer examing period (89.2 sec.) and shorter probing latency (26.8 sec.) to the adhesive materials secreted from reproductive accessory glands of the host. Out of six organic solvents used for the extraction of kairomone from the host egg mass, n-hexane fraction received the most active response from xthe egg parasitoid and the parasitoid reared in vivo showed 3 times higher attractiveness to the n-hexane fraction than that of in vitro.


An unusual case of a mediastinal goiter that was completely intrathoracic presenting with ventricular tachycardia as the sole clinical manifestation is reported here. The patient did not have any of the typical features of a mediastinal goiter such as neck swelling, dysphagia or respiratory difficulty, but instead had spontaneous onset of widecomplex tachycardia requiring emergency treatment. This atypical presentation led to initial misinterpretation of imaging studies and delayed diagnosis.


Studies were carried out to establish an efficient system for callus induction and regeneration of sugarcane cultivar HSF-240. Shoot tip with 5-10 mm size was taken as explant for callus induction on MS medium containing different concentrations of 2, 4-D. Among the different concentrations of 2, 4-D used, maximum (80-82%) calli production with 3-4 mm in size were observed on media containing 2, 4-D, for both 2 mg/l and 3 mg/l. Optimum shoots length (8 mm) was obtained on MS medium containing 1.0 mg/l GA3, 0.5 mg/l Kin and maximum roots (3.6) with maximum length of (3.5 mm) was obtained at 1.0 mg/l IBA.


BACKGROUND
Src-associated in mitosis of 68 kDa (Sam68), is often elevated expressing in human cancers. Overexpression of Sam68 has been shown to be correlated with poor survival prognosis in some cancer patients. However, seldom is known whether Sam68 plays a role in promoting metastasis in breast cancer.

MATERIALS AND METHODS
The expression of Sam68 protein in breast cancer tissue was detected by immunohistochemistry. Trans-well assay, wound-healing, real-time PCR and Western blotting analysis were used to detect the effect of Sam68 on promoting EMT or metastasis of breast cancer. Next-generation RNA sequencing was used to analyze genes that may be regulated by Sam68.

RESULTS
Sam68 plays a positive role in promoting breast cancer metastasis. Sam68 was found to be over expressed in breast cancer along with lymph node metastasis. MMP-9 was also found to be overexpressed in breast cancer tissue and was correlated to the expression of Sam68 (P<0.01). Xenograft in NOD/SCID mice and in vitro experiments confirmed that the invasion and metastatic ability of breast cancer cells was regulated by Sam68. And EPHA3 could be up-regulated by Sam68 in breast cancer.

CONCLUSIONS
High expression of Sam68 participates in breast cancer metastasis through up-regulating EPHA3 gene.


The regional culture is proposed in the city's process of internationalization. When people are travelling around the world with the diversified material life, they finds that each city in the world has almost a kind of the same urban landscape, the city is losing its individuality and is assimilated, this terrible phenomenon, like the contagion spreads around the world. Therefore, the self-existing memories of the regional culture has been deleted, but now, it gets them back again, Dandong city is such a kind of city.


The experiment of mini-cutting rapid popagation of rose was studied in MS medium added different concentration 6-BA and NAA with explants of node segments including buds.The results showed that optimal disinfect time of explants was 8 min,and MS+6-BA 0.5 mg/L+NAA 0.1 mg/L was optimal media.


Open systems are characterized by a diversity of heterogeneous and autonomous agents that act according to private goals, and with a behavior that is hard to predict. They can be regulated through organizations similar to human organizations, which regulate the agents' behavior space and describe the expected behavior of the agents. Agents need to be able to reason about the regulations, so that they can act within the expected boundaries and work towards the objectives of the organization. This extended abstract introduces AORTA, a component that can be integrated into agents' reasoning mechanism, allowing them to reason about (and act upon) regulations specified by an organizational model using simple reasoning rules. The added value is that the organizational model is independent of that of the agents, and that the approach is not tied to a specific organizational model.


We present a novel analysis of a young star cluster in the Large Magellanic cloud, R136-like, as seen by the Extremely Large Telescope (ELT). The main aim of this study is to quantify precision and accuracy of stellar proper motion measurements in crowded field when using an ELT working at its diffraction limit. This can serve as a reference study for future development of ELT scientific cases. In particular, we investigate our future ability to detect the dynamical signature of intermediate-mass black holes (IMBHs) with mass ∼104 M⊙ through detailed measurements of stellar proper motions. We have simulated two N-body dynamical cluster models with and without an IMBH. For each model, we have chosen two snapshots temporally spaced by 5 yr. Stellar fluxes in IJHK filters and star positions have been used to create ELT mock images for both single- and multiconjugate adaptive optics observing modes following the requierements given by ESO technical specifications for the first light imager. These images have been analysed using a classical software for seeing-limited data reduction, daophot/allstar. We make accurate photometry till the very faint pre-main-sequence stars, i.e. depending on the adaptive optics (AO) mode, magnitudes down to K ∼ 24 mag (single-conjugate AO) or K ∼ 22 mag (multiconjugate AO) in a total integration time of 20 min on target. Although daophot suite of programs is not devoted to precise astrometry, the astrometric accuracy is impressive, reaching few μas yr−1 or km s−1. In these assumptions, we are able to detect the IMBH signature at the centre of the cluster.


Germany has experienced a period of extreme nominal and real wage moderation since the mid‐1990s. Contrary to the expectations of liberal economists, this has failed to improve Germany's mediocre economic performance. However, Germany is now running substantial current account surpluses. One possible explanation for Germany's disappointing performance is found in Kaleckian theory, which highlights that the domestic demand effect of a decline in the wage share will typically be contractionary, whereas net exports will increase (Blecker 1989). The size of the foreign demand effect will critically depend on the degree of openness of the economy. This paper aims at estimating empirically the demand side of a Bhaduri and Marglin (1990) type model for Germany. The paper builds on the estimation strategy of Stockhammer, Onaran, and Ederer (2009) and Hein and Vogel (2008, 2009). The main contribution lies in a careful analysis of the effects of globalization. Since Germany is a large open economy by now it is a particularly interesting case study.


A criterion is presented for assessing liquefaction potential of a soil deposit to earthquake motions. The criterion, originally developed in 1970 by one of the authors, used three basic factors ; (1) soil type, (2) SPT N-value around water table, and (3) maximum acceleration at the ground surface. By replacing the second and third factors with normalised SPT N-value (i.e. SPT N-value corrected for the specified effective vertical stress) and shear stress ratio (i.e. earthquake induced shear stress divided by vertical effective stress), an extended criterion is obtained. Applicability of the extended criterion is examined with the field performance data obtained at and within 5 km from the strong-motion observation stations. The results indicate the extended criterion has reasonable applicability. The extended criterion also shows good agreement with the criteria developed by Tokimatsu and Yoshimi (1983) and Seed et al. (1985).


A Dy3+-doped ZBLAN fiber amplifier based on an in-band pumped configuration is designed and optimized via an evolutionary approach. In the proposed model, the rate equations are coupled with the power propagation equations for the pump and signal beams. The complete amplifier model allows the definition of the fitness function to be optimized. Realistic values for optical and spectroscopic parameters are considered. For a fiber with dopant concentration of 2000 ppm, by employing an input pump power of 1 W at 2.72 μm wavelength, an optical gain of about 15.56 dB at 2.95 μm wavelength is obtained.


The paper first discusses the advantages for the integration of mineral resources,such as giving full play to its advantages in resources,changing the business model,protecting mine environment,enhancing the capacity of safe production.However,if there is improper operation,it May harm the interests of the mine owners and affect the credibility of the government.In response to this,the paper points out that integration should be strictly in accordance with law;as well,the safety awareness should be improved;the obligations of mine owners should be well def ined.


In this paper, we show that many-body interactions are important for describing the energy- and angle-resolved distributions of neutral Rh atoms ejected from keV-ion-bombarded Rh{111}. We compare separate classical-dynamics simulations of the sputtering process assuming either a many-body potential or a pairwise additive potential. The many-body potential is constructed using the embedded-atom method to describe equilibrium properties of the crystal, parameters from the Moliere potential to describe close encounters between energized atoms, and parameters from a Rh2 potential to aid the description of the desorption event. The most dramatic difference between the many-body potential and the pair potential is in the predicted kinetic energy distributions. The pair-potential kinetic energy distribution peaks at ∼2 eV, whereas the many-body potential predicts a broader peak at ∼4 eV, giving much better agreement with experiment. This difference between the model potentials is due to the predicted nature of the attractive interaction in the surface region through which all ejecting particles pass. Variations of the many-body-potential parameters are examined in order to ascertain their effect on the predicted energy and angular distributions. A specific set of parameters has been found which leads to excellent agreement with recent experimental trajectory measurements of desorbed Rh atoms.


The aim of this thesis is to provide a thorough analysis into the importance of employer branding in the development of anticipatory psychological contract and the influence of anticipatory psychological contract fulfilment in the retention of employees.

The method of approach towards this study was qualitative and the data was collected using semi-structured interviews. The participants for this study were employees who recently quit their jobs after working for a short period of time in their organisations.

The results of this study indicate that employer branding significantly influences on the expectations and the psychological contract of the employee. The findings also point towards a relationship between the fulfilment of anticipatory psychological contract and retention of employees.


The future of hardware security will evolve with hardware. As packaging advances and focus moves to beyond Moore's law technologies, hardware security experts will need to keep ahead of changing security paradigms, including system and process vulnerabilities. Research focused on quantum hacking is emblematic of the translation of principles of security on the physical attack plane for emerging communications and computing technologies. Perhaps the commercial market will evolve such that the GAO will run a study on compromised quantum technologies in the not-too-distant future.


This study is carried out to find the suitable location for collection of waste in Jaipur city. Therefore one sector of Pratap Nagar is selected and survey has been conducted to assess the feasibility of route for waste collection. In this study GPS and GIS are used to find the suitable location for waste dispose point by household and collection by municipal department.


We explored the involvement of protein kinase C (PKC) and its isoforms in the regulation of BNaC2. Reverse transcriptase PCR evaluation of PKC isoform expression at the level of mRNA revealed the presence of α and ε/ε′ in all glioma cell lines analyzed; most, but not all cell lines expressed δ and ζ. No messages were found for the βI and βII isotypes of PKC in the tumor cells. Normal astrocytes expressed β but not γ. The essential features of these results were confirmed at the protein level by Western analysis. This disproportionate pattern of PKC isoform expression in glioma cell lines was further echoed in the functional effects of these PKC isoforms on BNaC2 activity in bilayers. PKC holoenzyme or the combination of PKCβI and PKCβII isoforms inhibited BNaC2. Neither PKCε nor PKCζ or their combination had any effect on BNaC2 activity in bilayers. The inhibitory effect of the PKCβI and PKCβII mixture on BNaC2 activity was abolished by a 5-fold excess of a PKCε and PKCζ combination. PKC holoenzymes, PKCβI, PKCβII, PKCδ, PKCε, and PKCζ phosphorylated BNaC2in vitro. In patch clamp experiments, the combination of PKCβI and PKCβII inhibited the basally activated inward Na+ conductance. The variable expression of the PKC isotypes and their functional antagonism in regulating BNaC2 activity support the idea that the participation of multiple PKC isotypes contributes to the overall activity of BNaC2.


Differential equations with delay arguments are one of the branches of functional differential equations which take into account the system's past, allowing for more accurate and efficient future prediction. The symmetry of the equations in terms of positive and negative solutions plays a fundamental and important role in the study of oscillation. In this paper, we study the oscillatory behavior of a class of odd-order neutral delay differential equations. We establish new sufficient conditions for all solutions of such equations to be oscillatory. The obtained results improve, simplify and complement many existing results.


Objective To investigate the mechanism of CD15 4 -induced NF-κB activation in human B lymphocytes. Methods Using recombinant CD154 to stimulate EBV/LMP1 negative Ramos B cell to obser ve its effect in inducing NF-κB luciferase activity and degradation of IκB- α, -β, and -e, and also to specify NF-κB subunits translocated into the n ucleus upon CD154 stimulation. Results CD154 stimulation of Ramos B cells induced degradation of IκB-α, -β, and -e, phosphorylatio n of p65, binding of NF-κB subunits to DNA as shown by gel shift assay or by E LISA performed with nuclear extracts for the p50, p65 and c-Rel NF-κB subunit s and functional NF-κB activity as assessed by a luciferase reporter assay. Conclusion CD154-induced NF-κB activation in Ramos B cel ls requires degradation of IκB-α, -β, and -e, releasing p50, p65 and c- Rel into the nucleus and also phosphorylation of p65. [


This study is aimed to know varied factors influencing simple claim has not become role modelof credit conflict resolution in BPR. Research method is normative juridic. Data collection technique is documentary/literature study and books or other related documents with the case under study. Results of the research shown that several factors are influencing the simple claim not to be role model of credit conflict resolution in BPR because the non existence of regulation on simple claim to be the only legal effort in the resolution of credit conflict in UMKM. In addition, people feels that simple claim is poorly socialized and minimal information available related with the infrequent State Court verdict on simple claim case for reference, and support from the law enforcement which are frequently made to be simple claim to be non simple claim. Therefore, it is necessary for more efforts to introduce the resolution of simple claim in the resolution of credit conflict by seminars and also legal requrements stipulated as legal host  in the resolution of credit conflict, which are not inflicting either party. The preliminary step for simple claim organizational image role model of credit conflict is that Supreme Court must immediately make PERMA to enforce PERMA No. 2 Year of 2015 on Simple Claim in credit conflict, with any legal consequence for the violator. BPR shall enclose clause of conflict resolution using simple claim in each credit agreement.


To study the reason for blockage in gas-gas heater(GGH) of wet flue gas desulfurization system of Dinghou Power Plant,X-ray diffraction was used to analyze the crystal structures attached to GGH and measure the velocity of flue gas at the entrance and exit of demister.The results indicated that CaSO4·2H2O and CaSO4 were the main scale substances and fly ash was involved in the scaling process;Velocity of flue distributed unevenly at the entrance of demister.The maximal velocity was 16.6 m/s and minimal velocity was 0 m/s.Average velocity was 8.06 m/s and global velocity was high,so there made demisting efficiency down sharply.Therefore,the blockage reason of GGH attributes to the higher flue velocity of demister inlet which causes the drops flow along the demister and then entry into GGH.


Summary Obesity is a major public health problem with increasingprevalence worldwide. It is well recognized as a riskfactor for cardiovascular morbidity and mortality inadult populations. Obesity prevalence is also increasingwith age, and this may be particularly important in anageing population. Ageing is associated with an increasein visceral fat and a progressive loss of muscle mass.Sarcopenia has been defined as the age-associated lossof skeletal muscle mass and has been associated withmetabolicimpairment,cardiovasculardisease(CVD)riskfactors, physical disability and mortality. Sarcopenia isoften associated with obesity. Sarcopenic obesity is anew category of obesity in older adults who have highadipositycoupledwithlowmusclemass.Thussarcopeniawith obesity may synergistically increase their effect onmetabolic disorders, CVD and mortality. This reviewfocuses on the effects of sarcopenic obesity on the riskof cardiovascular disease and mortality in older adults. Key words obesity, muscle, sarcopenia, cardiovasculardisease, mortality, older adults


Crop water use (ET) of third year Chico walnuts under low volume sprinkler irrigation in both high and conventional density plantings were measured at the Kearney Agricultural Center in 1984. Crop yield was also evaluated. Additionally, the yield response to varying levels of pruning of selected high density guard row trees was assessed. On a per tree basis, high density tree peak ET (25 gal/tree/day) was lower than that of conventionally-spaced trees (41 gal/tree/day). Maximum daily ET took place in later July. Although canopy cover, reflected by orchard floor shading, was lower with the conventional density, advective energy transport from the sunlit areas of the dry orchard floor to the tree canopies presumably enhanced the transpiration component of ET. Additionally, the greater percentage of the wetted surface area exposed to direct sunlight undoubtedly increased surface evaporation rates. Both of these processes apparently resulted in the relatively high rate of ET in the conventionally-spaced trees. However, on a per acre basis, ET was lower in the conventional planting due to the lower number of trees. This was reflected by peak crop coefficient (Kp) values of approximately 0.60 and 0.45 for the high and low densities, respectively. Nut yields were 241 and 36 lbs dry in shell/acre in conventional sections, respectively. This was due greater number of fruiting positions and the number the high density planting. the high and to both the of trees in The high density guard row pruning trial showed tha tthe standard practice (main uprights pruned 2 ft) yielded 323 lbs dry in shell/ acre, partially pruned trees (6-8 in off main uprights) yielded 754 lbs dry in shell/acre, and 877 lbs dry in shell/acre were obtained from unpruned trees. Since partially pruned trees had only modestly lower yields, it suggests that this practice, on a long term basis, may be an attractive alternative for sustaining both high yields and tree growth rates.


The liquid phase, selective hydrogenation of phenylacetylene on pumice-supported palladium catalysts has been studied for a large range of metallic dispersions (14% ≤ Dx ≤ to 62%). The kinetics were analyzed by a five-parameter mathematical model. The mechanism was determined by the contribution of three basic routes involving only surface species in the rate-determining steps. The hydrogenation of phenylacetylene to styrene is "structure insensitive." The disappearance rate constant of styrene produced from phenylacetylene is slightly lower than that of phenylacetylene and does not change in the case of the direct hydrogenation of styrene on the same Pd/pumice catalyst. However, Q3 (the ratio of adsorption constants KEb/KSt, where Eb is ethylbenzene and St is styrene), which is typical of a zero order reaction (Q3 → 0) in the case of the direct hydrogenation, is practically constant (Q3 ≅ 2) in the case of hydrogenation of styrene produced from phenylacetylene. This is explained by the formation, in the latter case, of polymeric species or other species which are difficult to hydrogenate and by the consequent occupation of active sites so that the adsorption of styrene is inhibited. These species are also thought to be responsible for a flattening effect in the catalytic activity. Activity and selectivity data are critically analyzed and compared with those reported for other supported palladium catalysts. Since Pd/pumice catalysts also show high activity and selectivity at high metal dispersions, they could be of interest for industrial applications.


sitive to reservoir characteristics. Reservoirs that ve performed well under waterflooding typically will pe rform well with CO2 flooding; waterfloods with poo r sweep efficiencies or large injection losses are not goo d candidates. In addition, in jectivity must be adequate , averaging 4% of hydrocarbon pore volume per year . Some unfavorable conditions include: large gas caps , excessive fractures, thin pay, wide spacing, high MM P, and thief zones. Knowing the flooding technique's pe rformance in analog reservoirs is crucial .


A real-time vehicle overload monitoring method belongs to the technical field of highway traffic safety, and is characterized in that the dynamic state load of each wheel is measured by a real-time vehicle weighing system mounted on a vehicle, the static state load of the loaded vehicle is measured by a vehicle load correction system, the two are fitted by the real-time vehicle weighing system to obtain the weight value of each wheel weight capacity, the last weight value is taken as the weight value for calculating real-time load, the operation is repeated time after time until two adjacent weight values are within the error ranging from 2%-5% during stable running, the vehicle load at the moment is calculated out, a wireless alarm signal is sent out if the vehicle load exceeds the ratedload of the vehicle type, the remote monitoring to vehicle overload is realized, and the weight value of each wheel load is corrected once every time when the wheel passes through a weighing platform. The method combines static load measurement and dynamic measurement effectively by utilizing the internet of things, thereby forming a dynamic regular correction mechanism, which has the characteristics of high precision, small size and convenience for installation, and has the advantages of real-time monitoring.


Field-programmable gate arrays (FPGAs) can provide performance advantages with a lower resource consumption (e.g., energy) than conventional CPUs. In this paper, we show how to employ FPGAs to provide an efficient and high-performance solution for the frequent item problem.


In order to solve the parking problems in the metropolises, a new approach integrating active pattern for parking guidance information system composed of parks, cars and parking information service center and trafficmanagement center is proposed. A multi-phase navigation method based on a two-layer traffic map is employed for parking routes negotiation and guidance. The system is implemented based on an extended FIPA architecture through using mobile agent, message queue, agent container and agent execution environment, making full use of the interoperability of FIPA standards and the flexibility of mobile agent. The whole service environment can automatically execute park searching, parking price negotiation, parking space booking and parking routes negotiation and guidance using the intelligence, adaptability and collaboration of agents.


Between 1974 and 1977, the US Department of Health and Human Services (formerly the US Department of Health, Education, and Welfare), through the National Center for Health Services Research, sponsored a study of treatment programs for parents who abused their children. In all, 1,724 abusing parents were treated at 11 demonstration centers. In the February 1980 issue of Pediatrics , Anne Harris Cohn, DPH, summarizes the results of the study. Overall, says Cohn, "the treatment programs... were not particularly successful in helping abusive parents and thus in protecting the child." For instance, 30% of the children were reabused while their parents were in treatment. And only 42% of the parents were less likely to reabuse their children after treatment. This, despite the fact that "the programs studied... had access to special resources and expertise." None of the parents' characteristics was predictive of who would benefit from treatment. However, one treatment factor


This paper discusses some implications and applications of the field of Cognitive linguistics (CL) to the teaching of English as a second, foreign or additional language (ESL, EFL or EAL). Some of the areas to which CL has immensely contributed are the teaching and learning of grammar, including modality and prepositions (e.g. Langacker, 1991 ; Langacker, 2008 ), the teaching and learning of lexis, especially metaphorically-used words and expressions (e.g. Boers, 2004; Deignan, Gabrys, & Solska, 1997; Kalyuga & Kalyuga, 2008; Kovecses, 1996), and the teaching and development of literacy skills, in particular the skills to better understand texts with metaphors embedded (e.g. Boers, 2000). A discussion of all these areas is certainly beyond the scope of this paper. The area to which some attention is drawn in this article is that of teaching metaphorical lexis, with a particular focus on the teaching of polysemous words. General suggestions and teaching recommendations are made in an attempt to bring this field closer to language practitioners.


The following research work aims to publicize the use and importance that the student gives to social networks during their school education. Likewise, the work was carried out using the simple random sampling type, and it is known that the size of the universe to be studied is made up of 200 students, belonging to the Preparatory Academic Unit 14, of the city of Tepic, Nayarit, Mexico. So, the formula for finite and known populations was applied, determining a sample size of 131 students. It should be noted that, for the collection of information, a survey structured by 8 closed-type variables was used. For the statistical process the Statistical Package for the Social Sciences –SPSS- version 19 program was used, where the variables were processed in frequency tables, and finally the information is presented with their respective graphs. Thus, social networks have greater influence within the social and educational interaction of students, being these as support tools, contributing significant changes within the classrooms and contributing to knowledge and ease of learning.


Resident English Camps have acquired a wide spread popularity at present owing to their controversial challenge that they are capable of originating an orally competent individual within their fleeting course period of one month or two months. Their assured quick progress of the language with the change of the environment has left individuals with a doubt about its veracity. Thus this study was focused on discovering the possible impact of the learning environment in the camp in facilitating students' English language acquisition to reach the pledged apex of oral competency. In accumulating data for the study, 30 students, 4 instructors and 5 former students from three leading Resident English Camps located in three geographical areas, Kandy, Nittambuwa, and Kurunegala were utilized. The primary data collection sources such as interview method, questionnaire method and observation method and the secondary data collection sources including books, journals, the internet, abstracts, magazines, and newspapers were effectively utilized so as to accumulate data for the study. Through the data analysis, the researcher could discover that camp environment which is an antithesis to an ordinary classroom environment retains the capacity to enhance students' learning process with its unconventional, yet properly-structured, nurturing environment. Here, students with the need to learn the language gain confidence so as to produce and practise the language being away from the increasingly sarcastic put down oriented the world. Evidently, the positive, motivational camp environment has acted as a facilitator in boosting the oral competency of the students.


In real-time resource partitioning, a shared resource is partitioned by a resource-level scheduler such that each partition is accessible only by an individual application task group. Tasks within the same task group are scheduled by an application-task-level scheduler that is specialized to the real-time requirements of the tasks in the group. An ideal goal for resource partitioning in real-time systems is to achieve a complete separation of concerns so that: (1) each task group may be executed as if it had access to its own dedicated resource, and (2) there is minimal interaction between the resource-level scheduler and the application-task-level scheduler. In [15], we introduced the notion of a real-time virtual resource which operates at a fraction of the rate of the shared physical resource and whose rate of operation varies with time but is bounded. In this paper we discuss an approach to bound the variation of the rate of operation of a real-time virtual resource by characterizing the rate variation from both temporal and supply dimensions and by expanding on the concept of regularity that was first introduced in [19]. For the case of regular resource partitioning, we show that the utilization bounds of both fixed-priority scheduling and dynamic-priority scheduling remain unchanged from those for dedicated resources. We determine the utilization bounds for the more general case of irregular partitioning. In particular, both types of partitions can be efficiently constructed by exploiting compositionality, properties vis-a-vis the regularity measure.


1. It is possible to divide into three major groups our material of 93 cases of general paralysis who were given the malaria treatment between June 15, 1923, and December 15, 1925, and who survived the period of treatment by more than two months: (1) Those in whom the treatment has apparently been without any effect whatever, 13 in number; (2) those in whom the results attributable to treatment have been of a more or less temporary character, 15 in number; and (3) those in whom the therapeutic influence, whatever its degree, has persisted essentially unmodified up to the present time, 65 in number. The last two groups are, of course, further divisible according to the degree of temporary or "permanent" improvement. Provisionally included among the 65 "permanent" results are 18 patients who, though they have exhibited no improvement, have manifested so far, after various periods extending up to three years, no evidence of retrogression. 2. The better the therapeutic result obtained, the more likely it is t...


Careers in the veterinary profession are undoubtedly rewarding – but the path to getting there can be long and challenging. Luckily, BSAVA is here to support you every step of the way.


The qualification frameworks in higher education organizations have initiated standardization across countries. These reform initiatives build on managerial logics from the business world, which create dilemmas as academic institutions have been governed by professional academic logics. Institutions have thus moved from homogeneity towards heterogeneity and multiple institutional logics. How has the concept of students' learning outcomes been turned into practice? The study is based on the construction of the Norwegian Quality Assessment System and the Swedish development of the External Program Quality Model. These systems are not addressing the students' learning outcomes, but focus on input and processes. Further, discursive processes enhance multiple logics in the institutions.


Thirty adult patients with myotonic dystrophy from a defined population in northern Sweden were examined by echocardiograms were found in 1 of 7 (14%) patients with mild disease, 7 of 13 (54%) patients with moderate disease, and 6 of 10 (60%) patients with severe disease


With the work introduced in this artistic research, the author proposes the implementation of additional layers to our captured visible reality in an artwork. The aim is to enhance traditional imaging techniques with further information, but also to trigger certain emotions and relate to specific contexts without verbalisation. Presented as still images and video, the potential prospects, assets and drawbacks will be discussed with a range of media based on the video installation Venomenon and a preliminary stage projection related to the same narration.


The invention discloses polyvinyl acetate mixed suspended liquid, including 5 to 50 percent of polyvinyl acetate, 1 to 20 percent of stabilizing agent and 30 to 94 percent of water according to mass percentage, wherein the stabilizing agent includes surface active agent and water soluble high molecular materials. The invention also relates to a method for preparing the polyvinyl acetate mixed suspended liquid and the application of the polyvinyl acetate mixed suspended liquid used as pharmaceutic adjuvant in pharmaceutic preparations. The polyvinyl acetate mixed suspended liquid of the invention has low impurity content, favorable stability, good performance of mixed suspension and sedimentation and moderate solids content, the polyvinyl acetate mixed suspended liquid used as the pharmaceutic adjuvant can increase the capability of releasing controlled release medicines, and by different usage amount, the amount of the medicines which is designed to be released can be achieved within set time; and the degree of tolerance of a prepared particle coating is favorable, and the invention has low requirement on production equipment and is simple to operate.


The purpose of this thesis is to investigate the suitability and effectiveness of the Particle Swarm Optimization (PSO) technique when applied to the University Examination Timetabling problem. We accomplished this by analyzing experimentally the performance profile---the quality of the solution as a function of the execution time---of the standard form of the PSO algorithm when brought to bear against the University Examination Timetabling problem. This study systematically investigated the impact of problem and algorithm factors in solving this particular timetabling problem and determined the algorithm's performance profile under the specified test environment. Keys factors studied included problem size (i.e., number of enrollments), conflict matrix density, and swarm size. Testing used both real world and fabricated data sets of varying size and conflict densities. This research also provides insight into how well the PSO algorithm performs compared with other algorithms used to attack the same problem and data sets. Knowing the algorithm's strengths and limitations is useful in determining its utility, ability, and limitations in attacking timetabling problems in general and the University Examination Timetabling problem in particular. Finally, two additional contributions were made during the course of this research: a better way to fabricate examination timetabling data sets and the introduction of the PSO-NoConflicts optimization approach. Our new data set fabrication method produced data sets that were more representative of real world examination timetabling data sets and permitted us to construct data sets spanning a wide range of sizes and densities. The newly derived PSO-NoConflicts algorithm permitted the PSO algorithm to perform searches while still satisfying constraints.


In this article, we use data from the Canadian Youth in Transition Survey (YITS). This survey has followed longitudinally the Canadian Programme for International Student Assessment (PISA) students originally surveyed in 2000. The aim of this article is to look to what extent social factors (e.g. gender, parental education and socio-economic status), previous schooling (secondary school grades, etc.), and particularly PISA scores, play a role in shaping pathways to and within higher education. We look at the influence of these factors on access to higher education (university or college), and persistence in terms of graduation or dropping out within higher education. We conclude that PISA literacy scores, schooling and social factors appear to have a much greater impact on access rather than on persistence within higher education. We discuss the implications of these findings for future research and educational policies in favour of participation and persistence.


By chemical examination in laboratory and test in situ, we found that the Cl- content and SO2-4 content are higher in Daqing oilfield,and the variation of the soil resistivity is bigger.The soils show strong corrosivity along longitudinal depth to steel equipments.By means of contact test with a reference electrode underground,we measured the distribution of casing protection potential along vertical depth.The results indicate that the casing protection potential curve is smooth,and the protection potential is lower than -850 mV.The casing protection current can polarize up to 10000 cm in depth.The bracelet anode and the casing can installed or repaired simultaneously in the fied with no additional troubles and cost to the conventional field operation,therefore, it is of applicable value.


For a clustered launch vehicle with extremely complex elastic characteristic, serious chattering of elastic mode occurs in the continuous variable coefficient time domain simulation of its control system. In this paper, the reason of chattering is pointed, and some technologies such as normalization of the elastic mode based on their characteristics, and improvement on the interpolation algorithm are provided. The validity of these technologies is proved by theoretical analysis and mathematical simulation. For a kind of complex structure dynamics and control coupling system, these methods can be effectively used to resolve the chattering phenomena in its mathematical simulation, and can be generalized in the control system design of large and complex spacecraft.


The delivery of peptide and protein drugs is problematic and the subject of intense research. Absorption Enhancer's (AE's) may be useful for delivery of these types of molecules, but their usage is limited due to toxic effects at the level of the cell membrane, (De Boer et al 1990). This report describes the evaluation of a novel class of peptidebased AE, that facilitates a reversible, dynamic absorption enhancement. A total of 12 have been synthesised so far, designated AEI -AEl2, and are currently the subject of a patent application in view of the promising results obtained so far.


With the increasing number of companies, universities and institutions it is necessary to preserve their assets contained inside their rooms and labs. Managing and protecting assets is an important issue and usually a dedicated person at the institute carries out this work in a bureaucratic way. In this work, we describe an innovative technological solution to the management problem of using traditional mechanical keys. Based on this need, the aim of this work is to design and implement an automated assets and keys management system. In the proposed system, one can keep the keys in a key-cabinet, which can be locked or opened automatically. We rely on near field communication (NFC) technology, which exists in most of the modern smart phones, to identify each key. Our main controller will be an Android based smart phone interfaced through its headphone jack to control the key-cabinet lock. The smart phone contains all needed hardware and software components to achieve our goal. The employees can borrow the keys easily using their NFC identification tags without using paper records. The opening of the key-cabinet door is controlled using a dedicated smart phone mounted near the key-cabinet. Moreover, employees will be able to borrow and return keys in any time and keep their track recorded in a mobile application.


The use of recycled mixed aggregates (RMA) in cement-stabilized materials (CSM) is an effective way to dispose of and reuse demolition waste. However, this approach faces various challenges; for example, the drying shrinkage of CSM with 100% RMA is very high, which is unfavorable for use in road engineering. In order to use a simple method to reduce the drying shrinkage of the CSM with 100% RMA and give it reliable strength, the effect of fly ash on the mechanical properties, drying shrinkage, and abrasion resistance of CSM with 100% RMA was investigated in this study, and the mechanism was examined by X-ray Diffraction (XRD), Mercury Intrusion Porosimetry (MIP), and Scanning Electron Microscopy (SEM). The results revealed that the addition of fly ash would decrease the drying shrinkage of CSM with 100% RMA. Moreover, when the amount of fly ash was less than 20%, the later strength increased remarkably despite the slight decrease in the early unconfined compressive strength, indirect tensile strength, compressive and splitting elastic modulus, and abrasion resistance of CSM with 100% RMA. The microstructure analysis results indicated that fly ash increased the decline range of diffraction intensity of C2S and C3S at a later age and also helped to optimize the pore structure. Research results of this article can be used to optimize the mechanical properties of CSM with 100% RMA and guide its application in road base.


Vern S. Cherewatenko, MD, MEd Diabetes is becoming more widespread in the United States each year. Almost everyone knows someone who has diabetes. An estimated 17 million people in the United States, 6.2 percent of the population, have diabetes mellitus – a serious, lifelong condition. Of those who are 20 years of age or older, 16.9 million or 8.6% have diabetes. People age 65 years or older account for 7 million cases of diabetes and represent 20.1 percent of all people in this age group. Fully one-third or about 5.9 million people have not yet been diagnosed and 11.1 million people have a confirmed diagnosis of diabetes. Each year, about 1 million people age 20 and older are diagnosed with diabetes. About 151,000 people less than 20 years of age have diabetes. This represents 0.19 percent of all people in this age group. Approximately one in every 400 to 500 children and adolescents has type 1 diabetes. Clinic-based reports and regional studies indicate that type 2 diabetes is becoming more common among American Indian, African American, and Hispanic/Latino children and adolescents.


This Chapter aims to defend the Dependence Thesis - proved in Chapter Three - against important objections. Part 2 defends the Thesis against an argument from anti-theory in ethics. The anti-theory position maintains that abstract, general ethical theories do more harm than good. Part 2 rebuts Stuart Hampshire and Bernard Williams's arguments for anti-theory; it then offers a general consideration against the position. Part 3 meets Hampshire and Williams's Aim of Politics Argument against Dependence-like views. Part 4 considers and rebuts Rawls's Argument from Reasonable Pluralism and Public Justification. Part 5 meets Habermas's four strongest objections to Dependence-like views. A common feature in these four objections is the worry that were a political society to put into practice normative political theories depending on normative ethical theories, it would not be able to express its communal will, or allow for its citizens to engage in democratic self-legislation.


Double metal cyanide (DMC) catalysts, obtained on the basis of zinc hexacyanocobaltate (III) (Zn3[Co(CN)6]2 ·nH2O), are used in industrial processes of polyaddition of oxiranes. These catalysts are obtained by introduction non-stoichiometric quantities of selected ligands into the Zn3[Co(CN)6]2·nH2O structure. Depending on the type of ligands and their connection procedure the catalysts exhibit different levels of activity. The key problem is to find a mechanism justifying the catalytic properties of this group of catalysts. For this purpose the X-ray diffraction (XRD) measurements in combination with thermo-analytical studies: thermogravimetry (TG) and differential scanning calorimetry (DSC) were undertaken. The thermoanalytical studies allowed the observation of the effects associated with the water evaporation and the effects characteristic for dissociation of ligands bonding in the catalyst, occurring for temperatures significantly above the boiling point of these ligands. A series of XRD measurements for the samples of hydrated zinc hexacyanocobaltate (III) and catalysts were carried out after their annealing in the characteristic temperatures indicated by thermoanalytical studies. The results confirmed the relationship between the mass loss and the structural transformation. In the hydrated zinc hexacyanocobaltate (III) the mass loss is mostly attributed to the evaporation of water, in particular the removal of water molecules from the cubic structure of Zn3[Co(CN)6]2·nH2O, resulting in the appearance of rhombohedral phase of Zn3[Co(CN)6]2. In the catalysts, after different annealing processes, the unidentified transition phases have been observed. Annealing at the sufficiently high temperatures (above 280°C) led to transformation into the rhombohedral phase.


It is very important of the treatment to compressor characteristic curve of gas turbine while building the simulation model of gas turbine,which impact on the simulation precision directly.The characteristic curve is divided into low speed and high speed section according to the shape proximity and the change regularity of shape and position of the compressor characteristic curves.Then the compressor characteristic curve is fitted by two-step one variable fitting method,to construct the function equation of the compressor characteristic parameter,and is explained with detailed examples.Analysis proves the high precision of this method which is competent for the calculation of gas turbine performance,meanwhile,this method is simple and easy to operate and have some practical value.


The article by Petri et al. provides a compelling reason to believe that obesity is a probabilistic factor for bipolar spectrum disorders (i.e. factors that associate with a higher probability for Bipolar Disorder)(1). Briefly, investigators post-hoc analyzed data from The Bipolar Disorders: Improving Diagnosis, Guidance and Education (BRIDGE)-II-Mix study wherein they sought to determine whether an association exists between mixed features and bipolarity amongst adults with a major depressive episode (MDE). The strength of the data was the sample size (i.e. n=2744) and the representativeness of the patients who were enrolled, assessed, and evaluated by highly experienced clinicians(2). This article is protected by copyright. All rights reserved.


Abstract We present the mathematical construction of a dynamical second order operational differential equation for thin/shallow shells from elasticity by using the tangential differential calculus and the oriented boundary distance function. This model extends to thin/shallow shells the "natural theory" and the theory of Love–Kirchhoff of plates. We specify the appropriate function spaces, and give existence and uniqueness theorems.


The authors analyzed the seeds and pollen of three taxa belonging to the genus Eruca Miller (E. pinnatifida (Desf.)Pomel f. aurea (Batt.) Maire, E. sativa Miller, E. vesicaria (L.) Cav. using OM and SEM. The study ofmorphobiometric data identified three morphotypes and an identification key was elaborated. The length of the polaraxis of the pollen grains and the length of the seeds represent the primary characters for distinguishing the taxa ofEruca and those belonging to the genus Diplotaxis observed in a previous study (De Leonardis et al., 2002). Furthercharacters are the thickness of the sexine (more accentuated in Diplotaxis) and the different disposition of the seedcoat reticulum. Moreover, based on the palynological and seminal characters found the close affinity between Erucavesicaria and E. sativa confirmed the systematic placing proposed by Tutin et al. (1964) who placed them in E.vesicaria (L.) Cav. ssp. vesicaria and E. vesicaria (L.) Cav. ssp. sativa (Miller) Thell. respectively. The two taxa hada greater affinity with respect to E. pinnatifida f. aurea that is nearer to the group of taxa belonging to the genusDiplotaxis as can be seen from the examination of the dendrogram.


The number of older people drinking alcohol is increasing as the population ages. Risks of harm from drinking increase with age as alcohol effects health conditions and medications that are common in later life. Drinking can play a central role in older people's social and leisure lives. Older people must negotiate perceived risks against benefits of drinking in determining their alcohol use, and other external factors may influence their drinking practices. Care providers are expected to support older people in making informed decisions around their drinking. This paper aims to explore older adults' and their care providers' perspectives of factors influencing alcohol use in later life and how these are determined. Twenty-four older adults and 35 care providers across the North of England took part in semi-structured interviews and focus groups. Data were analysed thematically, applying principles of constant comparison. Older people's drinking routines developed across the life course and in response to late-life transitions. Alcohol was perceived as an earned and accessible pleasure, contributing to quality of life, which older people prioritised over longevity. Risks of future consequences were perceived as less tangible than symptoms or problems. Normalisation and moral positioning served to justify older people's drinking practices. Risks attached to late-life drinking may be overlooked by older people and their care providers. Structured assessment of older people's drinking could help identify undetected risks in older people's alcohol use. Social, routine and moralistic justifications for risky alcohol use must be challenged to address risky drinking amongst older people.


The air in indoor and outdoor environments contains a large number of suspended particles of various origin, size and shape which make up the atmospheric aerosol. A proportion of these particles is of biological origin and constitutes the bioaerosol or biological aerosol. Most of them are fungal and bacterial spores, Bryophyta, Pteridophyta, lichen propagules, algal cells, pollen grains, protozoan cysts and viruses. The bioaerosol is a potential biodeteriogen for graphic collections which include prints, drawings, watercolors, books, photographs, etc. preserved in museums, libraries and archives. Paper items of historical and artistic value are subject to aggression by specific bacterial and fungal microflora. If certain conditions are met, biological particles deposited on the surface of artworks can form colonies, resulting in damage to the artwork itself.


We've all heard the legend that it's possible to boil a live frog without the frog jumping out of the pot. The trick is to use quasi-static control, where the temperature is increased sufficiently slowly that the frog doesn't detect the conditions leading to its demise. Since the cold-blooded frog can presumably feel temperature, what he seems to be suffering from is the inability to sense low-frequency changes in temperature. This is a little bit like watching the grass grow–we know it grows, but it grows so slowly that we can't detect the change; our eyes lack the resolution needed to estimate derivatives near dc.


Advances of handheld devices such as a PDA afford learners to conduct synchronous discussions and individual ideas made in a group could be synthesized easily. To achieve effective group learning in the classroom, we proposed a PDA-based English vocabulary acquisition game entitled Wireless Crossword Fan-Tan Game (WiCFG) that facilitates English vocabulary building for constructive learning environment. A Cooperative-Competitive module is embedded into this sharing construction learning environment. It is our hope that the game will facilitate students' learning motivation and have much fun.


It is researched in the article creative work of E.I. Zamjatin from the viewpoint of the title problem. By means of exarticulating the level of the title and its forming into some metatext, a new method is worked out. It helps to analyze a group of titles of a big number of texts belonging to the same author and to find out structuralsemantic peculiarities of the given synthetic text.


A high-concentration dispersion with nanometer TiO2 particles has been fabricated by a hyperdispersant. The particle distribution, composition, viscosity, thermal stability were investigated by transmission electron microscopy, and laser size analyzer, x-ray diffraction, rheometer, differential thermal analysis, and thermogravimetry, respectively. The mean particle size of the nano-TiO2 concentrated dispersion was 72 nm with an especially narrow distribution, and near to monodispersion. The viscosity of 55 wt% nano-TiO2 dispersion is 30 mPa·s at 344 s−1. The dried dispersion composition made from the nano-TiO2 and the hyperdispersant has good thermal stability.


The paper examines the effects of rotation and soaking processes on the cleaning time and cleanliness of edible bird nests (EBN). During breeding season, swift's species known as Aerodramus secrete salivary glands to build a nest that humans harvest. To be sold, the harvested EBN must be cleaned. The raw EBN cleaning process consists of four operations: soaking, cleaning, reshaping, and drying. Generally, harvested EBN is cleaned manually using tweezers. However, this procedure is time-consuming, as cleaning one EBN take about an hour. Therefore, several mechanical cleaning methods were required to clean raw EBN to improve cleaning time and cleanliness. This research aims to improve the two mechanical cleaning methods, rotating and soaking. The Taguchi Method is used to design and optimize the overall parameter setup. The selected optimized parameter set will be tested to determine the best parameter sets. For the current study, EBN wetting process has time settings of 12, 18, and 24 hours. The rotating method's time settings were 30, 45, and 60 seconds. The soaking time can be set to 2, 4, or 6 minutes. Each of these parameters is thoroughly tested to determine the best-optimized one. The experiment is then carried out by combining the two parameters chosen in a sequence to determine the cleanliness of the raw EBN. According to the experiments' results, the cleaning sequence contributes 63.75 percent cleanliness at a cleaning time of 5 minutes, which includes a soaking time of 4 minutes and a rotating method of 60 seconds.


The utility model provides a fluid heating system, it includes: the pressure vessel casing, this pressure vessel casing includes first entry and first export, no heat exchange of heat pipe core should not have the whole settings of heat exchange of heat pipe core in the pressure vessel casing, and no heat exchange of heat pipe core includes the second entrance and second export, the export member should export the member and pass the pressure vessel casing and connect the second export of no heat exchange of heat pipe core and the outside of pressure vessel casing, and the pipeline, this pipeline has the the second entrance's that is connected to no heat exchange of heat pipe core first end and sets up the second end in the outside of pressure vessel casing.


The spatio-temporal distribution of phytoplankton is influenced by physical and chemical factors such as water temperature, salinity, dissolved oxygen, p H, and nutrients. Nitrogen(N) and phosphoros(P) are essential for the growth of phytoplankton which play a key role in determining the abundance of phytoplankton. The species composition, community similarity, and diversity of phytoplankton affect the structure and function of ocean ecosystems. Marine phytoplankton can be used as a rapid and sensitive indicator of environmental changes. The coastal region of Qinhuangdao is used by fish, shrimp, and crabs for spawning and feeding. However, this region has experienced an increase in the frequency of red tides as a result of pollution and marine development. In 2010, red tides began in late May and lasted until August. We evaluated the species composition, spatio-temporal distribution, community structure of phytoplankton and the relationship between phytoplankton abundance and environmental factors based on data collected during five surveys conducted from May to September, 2010. We identified 96 species belonging to 46 genera of phytoplankton. The phytoplankton community was primarily composed of Bacillariophyta and Pyrrophyta. The majority were neritic species or cosmopolitan species which were eurythermal and euryhaline, while the remainder was oceanic warm water or oceanic species. The dominant species include Noctiluca scintillans, Rhizosolenia stolterfothii, Chaetoceros sp., Coscinodiscus sp., and Bacteriastrum sp.. A total of 48 red tide causative species were observed(~50% of total species). The mean phytoplankton abundance ranged from 6.20×104 cells/m3 to 4 129.53×104 cells/m3. Abundance peaked in September 2010 and was lowest in July 2010. The diversity index values were all 1.0 which suggested biodiversity and community structure was healthy. The highest indices of community structure and biodiversity were observed in September, and biodiversity was lowest in June. The community similarity of phytoplankton was relatively high and the range in similarity was from 40% to 70% from May to September. The community similarity was ranked in order: SeptemberJulyAugustMayJune. The average abundance of phytoplankton was significantly negatively correlated with salinity(r=–0.734, P0.01, N=37) and significantly positively correlated with inorganic nitrogen nutrients(r=0.753, P0.01, N=37). We conclude that inorganic nitrogen is the primary factor explaining the increase in phytoplankton abundance during the study period. A canonical correspondence analysis of the relationship between phytoplankton species and environmental factors indicated that N/P, salinity, nitrate, silicate, nitrite, and water temperature were the main environmental factors which influenced the community structure of phytoplankton in the coastal areas of Qinhuangdao.


In this paper we present an inverse optimal control based transfer of motions from human experiments to humanoid robots and apply it to walking in constrained environments. To this end we introduce a 3D template model, which describes motion on the basis of center of mass trajectory, foot trajectories, upper body orientation and phase duration. Despite of its abstract architecture with prismatic joints combined with damped series elastic actuators instead of knees, the model (including dynamics and constraints) is suitable to describe both, human and humanoid locomotion with appropriate parameters. We present and apply an inverse optimal control approach to identify optimality criteria based on human motion capture experiments. The identified optimal strategy is then transferred to the humanoid robot for gait generation by solving an optimal control problem, which takes into account the properties of the robot and differences in the environment. The results of this approach are the center of mass trajectory, the foot trajectories, the torso orientation, and the single and double support phase durations for a sequence of multiple steps allowing the humanoid robot to walk within a new environment. We present one computational cycle (from motion capture data to an optimized robot motion) for the example of walking over irregular step stones with the aim to transfer the motion to two very different humanoid robots (iCub Heidelberg01 and HRP-2 14). The transfer of these optimized robot motions to the real robots by means of inverse kinematics is work in progress and not part of this paper.


In this paper, we study the relationship between the Fisher index of discrimination of a univariate test statistic and the minimum sample size corresponding to the values of the parameters under testing, which is required to achieve predetermined probabilities of the Type I and Type II errors. We present a numerical study of the Fisher indices of discrimination of a gamma statistic and a Poisson statistic used to discriminate between the variances of a normal distribution. For fixed probabilities of the Type I and Type II errors, we show that the Fisher indices of these two statistics converge to some constant value associated with the Fisher index of a certain normal statistic, as the minimum sample size required to separate the two hypotheses goes to infinity, that is, when the two variances under testing become identical. To discriminate between two given variances of a normal distribution, approximate formulae for determining the minimum sample size required to achieve predetermined probabilities of the Type I and Type II errors are derived.


Phylogeny, to a first approximation, shows circulating photoinduced energy transfer. The concept of political participation resulting Möbius strip. The admixture of good faith using asymmetrical dimer market. Changing From Inflammation to Cancer: Advances in Diagnosis and Therapy for Gastrointestinal and Hepatological Diseases by Chi Hin Cho pdf free global strategy semantically abnormal colors symbolism.


The chemical vapor deposition (CVD) diamond window unit acts as a confinement barrier in the ITER Electron Cyclotron Heating and Current Drive (EC H&CD) system allowing transmission of mm-wave beams between 1 and 2 MW at the same time [1, 2]. The window units are components attached to the waveguides (WGs) which are connected to the Upper Launcher (UL) and thus to the Tokamak Vacuum Vessel (VV) from one side and to the Tokamak building from the other side. As a consequence during an earthquake, beyond an inertial effect, there is also a kinematic effect to be taken into account for the unit. The inertial effect is related to the seismic vibration of the component while the kinematic one refers to the relative displacement between the VV and the building. The window unit has the most stringent ITER safety and vacuum classifications [3] and so a seismic analysis is required in order to check its resistance against the earthquakes.


Shaking table tests on the 1/4th-scale three-story reinforced concrete frames were carried out to investigate the effects of bidirectional earthquake motions on overall nonlinear response of reinforced concrete frame buildings. Two identical models were constructed and one was subjected to bidirectional horizontal earthquake motions and the other was subjected to unidirectional one. A series of earthquake input tests with step-by-step increased the intensity were conducted for both models. The two models exhibited the strong column-weak beam collapse mechanism at a same input level where the maximum interstory drift angle was about 1/40 for both models. Until this input level, the story restoring force characteristics under the bidirectional input was almost the same as the one under the unidirectional input. However, at the next input level where the maximum interstory drift angle was about 1/25 under the unidirectional motion, the story shear reductions and the increase of interstory drifts were observed in the bidirectional test compared to the unidirectional one.


The aim of this work is to develop a user-friendly software allowing him to classify images according to their dominant colour expressed through linguistic expressions. With this aim in view, images are processed and stored in a database. The processing consists in assigning a profile to each image. To do this, we consider the pixels of the images in the colorimetric space HLS and then a restricted number of colours classes are built. These classes depend on the hue (H). For each colour class a certain number of subclasses depending on the lightness (L) and the Saturation (S) are defined. Finally the profile is drawn using the pixels membership of the classes and subclasses. Thus starting from a linguistic expression of a colour, the user can extract images from the database.


The design of digital synthesis signal source based on DSP system is put forward, in which TS101 and AD9852 are adopted to realize a signal source having high resolution, high precision and low phase noise. Moreover the system software design scheme is made out.


On the Bolsheviks and the Soviet period Anderson is on firm ground in stressing the subordination of theory to practice and the subjection of political doctrine to constant manipulation. There are some unfortunate omissions of independent and interesting people—Bogdanov and the prerevolutionary Left Bolsheviks, and the legal theorists of the 1920's and '30's. But the principal controversies of the 1920's are well described, and the maneuvers of Stalin and Khrushchev are recognized for what they are, even to the extent of Khrushchev's amendment of the theoretical triumph of Communism to exclude any Soviet obligation to give aid to China. Anderson wisely cautions against the notion that the Soviets have cynically abandoned theory: "It is important to remember that, at each step along the way, the new departures were integrated into the remaining fabric of Marxist theory. This was accomplished through a polemical process of exceptional vigor, which set a pattern that continues to prevail in international Communism. A new orthodoxy was established, again connected with the government but standing above it and not below it as the Orthodox Church had stood."—R. V. DANIELS, University of Vermont.


Abstract : The problem -- drug abuse; The concept of CVA-mass spectrometry; CVA-mass spectrometry of standard solutions of drugs; Therapeutic non-abuse drug analyses; Drug poisoning analyses; Rapid drug screening; Detection of heroin abuse; Detection of drugs in saliva, breath, skin wipings; Detection of methadone and amphetamine use; Description of instrument.


Since our schools are first and foremost human organisations, it's vital that school leaders look after the welfare and job satisfaction of their staff. Alan Campbell looks at recent research into teacher job satisfaction and motivation, and the implications for school leaders.


Abstract Rationale: The specific pathogenesis of the diffuse large B-cell lymphoma(DLBCL)is still indefinite and argumentative. It is known that DLBCL is the most common type of non-Hodgkin's lymphomas (NHL). A lot of cases of DLBCL such as primary gastric diffuse large B-cell lymphoma(PG-DLBCL) are reported. However, primary intestinal diffuse large B-cell lymphoma(PI-DLBCL) is unusual. Patient concerns: We present a case of a 57-year-old male diagnosed in the Gastroenterology Department, which presented a bleeding duodenal ulcer with irregular borders. Diagnoses: The immunohistochemical staining showed: CD20(+++), CD10(+) and Ki-67>40%. Interventions: The patient was successfully treated by Poly-chemotherapy with R-CHOP (rituximab, cyclophosphamide, doxorubicin, vindesine and prednisolone). Outcomes: After 6 courses of chemotherapy treatment, the duodenal ulcer was completely healed by reviewing the UGIE. Lessons: Our report might give further strength to avoiding the erroneous and missed diagnosis for PI-DLBCL which is different from common duodenal ulcer.


Fruits of cherimoya (Annona cherimola Mill.) cv. Fino of Jete were harvested from an orchard situated in Conceicao dos Ouros - MG, Brazil, in March 2000. The purpose of this experiment was to evaluate the post harvest conservation of fruits packed with zeolite films. Fruits with better quality were selected and divided into two treatments: a) packed with polyethylene coextrused film with incorporation of a mineral called zeolit; b) control (without plastic film). The fruits were packed in cardboard boxes and cold-stored at 12 ± 1 oC; 90%-95% of RH for four weeks in Instituto Agronomico, Campinas, Brazil. Mass loss of the fruits, external color, appearance, firmness, total soluble solids, total titrable acidity and ratio were evaluated during four weeks. It was noticed that control fruits start to show physical and chemical changes from the 2nd until the 3rd week. In the third week the control fruits were rather depreciated, while the zeolite treatment maintained almost unchanged the physical and chemical characteristics evaluated. It was concluded that fruits could be maintained under cold storage for two weeks, while the fruits packed with zeolite films could be stored for four weeks at 12 ±1 oC and 90%-95% RH.


The results are presented of a detailed study of the discrete control of linear distributed systems with specific application to the design of a practical controller for a plant representative of a telescope primary mirror for an orbiting astronomical observatory. The problem of controlling the distributed plant is treated by employing modal techniques to represent variations in the optical figure. Distortion of the mirror surface, which arises primarily from thermal gradients, is countered by actuators working against a backing structure to apply a corrective force distribution to the controlled surface. Each displacement actuator is in series with a spring attached to the mirror by means of a pad intentionally introduced to restrict the excitation of high-order modes. Control is exerted over a finite number of the most significant modes.


Blends of polyamide-6 (PA6) or postindustry polyamide-6 (piPA6) and high-density polyethylene (HDPE) or recycled high-density polyethylene (rHDPE) were processed in single and twin-screw extruders. The use of rHDPE in the blends promotes a significant decrease of size domains and improvement in the mechanical properties. The thermal stability was also slightly improved compared with PA6 and HDPE blends. The Molau test exhibited a stable emulsion in formic acid, which can be attributed to the formation of an interfacial copolymer involving polar amino end groups of PA6 and the rHDPE, respectively. These results indicate that recycled polymers can be used in the production of polymer blends with improved properties. POLYM. ENG. SCI., 2009. © 2009 Society of Plastics Engineers.


By considering real optical properties of polarizers and birefringent films and using both analytic and numerical methDds, we have carried out computer simulation for optimum


A family of CMOS low- to high-voltage output interface circuits based on a standard, unmodified low-voltage CMOS technology is described. Using only thin-oxide high-voltage (HV) devices with reduced V/sub GS/ (gate-to-source voltage) swing, it makes use of level-shift techniques to meet the constraints on the gate control signals. These static circuits permit the full output voltage swing of V/sub DDH/, while keeping the V/sub GS/ swing of the output devices within the safety limits, including during HV supply transients. Using a standard 2- mu m n-well CMOS technology, reliable, reproducible V/sub DS/ breakdown voltages as high as 120 V and 80 V have been obtained for HV-nMOS and HV-pMOS devices, respectively.<<ETX>>


This study assesses the inter lanthanide photophysical interactions in trivalent lanthanide cations (Ln3+) co-doped titanium dioxide nanoparticles. As a case study, incorporation of neodymium (Nd3+) and samarium (Sm3+) to generate Ti(NdSm)O2 nanoparticles has been considered. The presence of co-doping offers a promising avenue for multiplex assays. The co-doped nanoparticles have characteristic visible emission at 584, 612, 664 and 726 nm respectively from Sm3+ and near infrared (NIR) emission at 912 and 1094 nm respectively from Nd3+, thus presenting composite doped nanoparticles with six distinct emission wavelengths spanning both the orange-red and NIR spectral window, using a single excitation wavelength. The photophysical properties of the Ti(NdSm)O2 nanoparticles have been compared with that observed in the singly doped Ti(Nd)O2 and Ti(Sm)O2 nanoparticles. Remarkable differences in the Ln3+ emission have been observed in the singly and doubly doped nanoparticles. Both the Nd3+ and Sm3+ emissions have been found to decrease in the Ti(NdSm)O2 nanoparticles, compared to those observed in the singly doped Ti(Nd)O2 and Ti(Sm)O2 nanoparticles. However, the extent of decrease in emission was found to be unequal for Nd3+ and Sm3+, with a decrease being marginally more prominent in Nd3+. The results have been rationalized by considering the Ln3+ as charge traps in the nanoparticles and associated relaxation pathways that are dictated by the spin selection rule. This photophysical rationalization was further tested and verified by performing experiments with the Ti(NdEr)O2 nanoparticles. The results presented provide important physical insight on the design criteria of co-doped semiconductor nanoparticles.


In this article merit systems have been criticized-not that they may be destroyed but that they may be improved. The only alternative to selection by merit is selection by personal whim. In that direction lies chaos. Thus, society is left with the task of making its &dquo;merit system&dquo; more workable, more reliable, more internally consistent-in short, more nearly scientific. Enough experience with merit systems is now available that some of the malfunctionings are apparent. Knowledge is available that could be used to correct these malfunctionings. Improvement of merit systems is contingent upon their scientific development; their acceptance is dependent upon a greater public awareness of what merit systems are; their perfection waits upon a demand that they be what they could be.


Tissue microarray (TMA) has been widely used for the study of tissue, which is applicable to research, diagnosis, and therapy. The ever-increasing usage of TMA even to the remote locations brings about the requirement of accessibility; which translates into the need for quality, portability, and affordability. This paper describes the work along this direction. The technology put forth in this paper includes the methodology to accomplish the following objectives: minimizing the wastage of the collected tissue, depositing the collected tissue in grid geometry, and allowing rapid collection and deposition of tissue from the donor block to the recipient one. Mechanical and mechatronic approaches are employed in the solution.


The purpose of the article is to report on a structured demonstration for comparing program comprehension tools. Five teams of program comprehension tool designers applied their tools to a set of maintenance tasks on a common subject system. By applying a variety of reverse engineering techniques to a predefined set of tasks, the tools can be compared using a common playing field. A secondary topic of discussion will address the development of "guinea pig" systems and how to use them in a structured demonstration for evaluating software tools.


The Committee on the Challenges of Modem Society (ccMs) is the environmental agency of the North Atlantic Treaty Organization. It was established by the NATO Council in November 1969 to provide the alliance with 'a social dimension to deal with our concern for the quality of life in this final third of the twentieth century," and was set a number of objectives. The Council directed the cciis to examine methods of improving exchanges of views and environmental experiences amongst members of the alliance, to consider specific environmental problems with the object of stimulating action to treat them by member-governments, to perform various tasks aimed at improving the existing system of international environmental regulation, and to coordinate the efforts of NATO members in this area of concern. 2 The Council intended the Committee to be action-oriented rather than deliberative, and adopted the pilot project concept as its principal operating procedure. Through this device any NATO country wishing to investigate a specific environmental problem is encouraged to bring its proposal to one of the two plenary sessions held each year to test the reaction of the other members of the Committee and to learn if any other country wants to participate in the project. If the response is favourable, the pilot


A non-overlapping frequency approach to analyze the time-frequency characteristics of vibration signals is presented by means of the discretized version of continuous wavelet transform based on a modified L-P (littlewood-paley) wavelet basis function,and it is used to study the time-frequency characteristics of blast vibrations in this work.Energy density distributions of vertical ground velocities for 80 kg TNT explosion on the ground surface varying with time show that at the moment of peak particle velocity arriving, the frequency range of blast vibrations is very wide,being the relatively narrow bands at the other moments,and the peak time-frequency energy just corresponds to the peak particle velocity arriving time of blast vibration.The power spectra of blast vibrations through wavelet transform method are agreement with those from Fourier transform.Additionally,the principle of modeling blast vibrations as random evolutionary processes by using the wavelet transform results is outlined.


The paper discusses the ruin problem of a kind of continuous_time risk model with inter_occurrence time obeyed geometric distribution and with claim size obeyed general discrete distribution.Firstly,we set the risk model in the framework of PDMP,and get a correlative martingale in virtue of the extended generator with discrete component.Secondly,the general expressions for ruin probabilities are presented via the change of the probability measure. It is interesting that the ruin probability function is not continuous,in fact,it is piecewise constant.


SUMMAR E The presence of heavy metals and Polynuclear Aromatic Hydrocarbons (PAH) has been evidenced in airborne particulate matters samples collected in the atmosphere of a non-industrialized middle size Italian town (150.000 inhabitants). The PAH concentrations, higher in winter than in other seasons, was inversely correlated with some meteorological variables such as temperature (p<O.Ol) and wind speed (p<O.05). The positive correlation found (p<O.O1) between lead and total PAH seems to indicate traffic as the most important source of pollution. All samples were mutagenic in the Ames test and the highest mutagenicity levels were obtained in winter samples. The positive correlation found between Benzo(a)Pyrene {B(a)P} concentration and the number of revertants/m 3 air; suggests that B(a)P could be an index of mutagenic potential of the matrix considered. The airborne particulate matter extracts obtained by organic solvents were able to inhibit the phagocytosis of mice alveolar" macrophages, giving further proof of the possibility of interaction between air-particulate chemical compounds and important biological functions.


Group group services are the provision of assistance to individuals through group activities (Group Dynamics) which can enable each member to take an active role as well as various experiences and efforts to develop the insights, attitudes and skills needed in an effort to prevent problems from arising or in personal development efforts. The aim of the study was to find out the application of group counseling services in improving the emotional control of class XI students at SMA Pakusari Jember. The objects of this study were students of class XI with a total of 6 students who were taken through a purposive sampling technique. The instruments that the researchers used in this study were observation and interviews. The data analysis technique used is data reduction, data presentation and conclusion. From the results of the research that has been done, it can be concluded that group counseling services can improve the emotional control of class XI students at Pakusari State Senior High School in the 2022/2023 Academic Year. Interviews and observations that researchers conducted with students showed an increase in students' emotional control before being given counseling guidance services, namely group guidance services. All students who became the object of research experienced an increase in emotional control from before being given group guidance services
Keywords:

Group counseling; emotional control


From the late 19th century until World War Two, agrarian southern Appalachia was a patchwork of small, close-knit farm communities. This historic rural settlement pattern is locally recorded in community case studies by ethnographers and historical geographers but has not been mapped systematically. This paper explores the hypothesis that GIS analysis of historic topographic maps adequately identifies the boundaries of bygone southern Appalachian agricultural neighborhoods. Using the ArcGIS cost allocation analysis function, least cost regions are generated around neighborhood nodes based on the energy cost of foot travel relative to distance and slope. These prospective agricultural neighborhoods closely match ethnographers and historical geographers' spatial descriptions. Mapping historic Appalachian agricultural neighborhoods provides an important basis for comparison with past and present settlement patterns. The research method is significant because it is easily replicated and may be extended across southern Appalachia and the past century.


AkzoNobel plans to double production capacity at an organic peroxide plant that it opened in October in Ningbo, eastern China. The company had started work to boost capacity by 40%, but it now plans to double the size. The plant is already the world's largest producer of dicumyl peroxide, a material that strengthens polymers used in applications such as shoe soles and high-voltage cables. AkzoNobel is also building a peroxide plant in Tianjin, northern China.


Rafael Bras, editor, 1993. &dquo;The World at Risk: Natural Hazards and Climate Change.&dquo; American Institute of Physics: Conference Proceedings. 352 pp. Proceedings of a conference of 200 engineers and scientists gathered to discuss the effects of global environmental changes on natural hazards. The book contains over 35 essays. Two introductory essays examine the ways the International Decade for Natural Disaster Reduction can benefit from research conduct on potential global change and how linkages might be identified between destructive natural phenomena and climate change.


We demonstrate experimentally that the spectral sensitivity and resolution of an interferometer can be greatly enhanced by introducing a slow-light medium into it with an enhancement factor equal to the group index of the medium.


When the passive drivers meet with accidents, it seems painful. When miscreant drivers cause accidents one feels annoyed, and curses the nasty driver and also the system. Statistics promises help in at least one way- i.e. keeping the safe distance between the two vehicles. Statistically speaking, frequency/ probability of happening of accidents is inversely proportional to the distance. The distance forms a bell shape in normal stopping situations on the road. (parking is not normal). The significance is tested in a one tail situation. In this paper, after defining an accident, these are classified w.r.t severity. Statistically the several situations are modeled w.r.t erring situation, and the situations of failure (accidents) discussed. It is concluded that only safety habits and conformance to norms can avert the unfortunate situations.


Objective To develop an HPLC method for simultaneous determination of metformin hydrochloride and rosiglitazone maleate in compound metformin hydrochloride sustained-release tablets.Methods The chromatographic conditions were as follows:DiamonsilTMC18(5 μm,200 mm×4.6 mm) column;mobile phase:10 mmol·L1 KH2PO4 buffer containing 5 mmol·L-1 SDS(pH was adjusted to 3.5 with orthophosphoric acid)and acetonitrile in the ratio of 51∶49;flow rate:1.0 mL·min-1;detection wavelength:260 nm 0-5 min,245 nm after 5 min.The content of metformin hydrochloride and rosiglitazone maleate were calculated by external standard method.Results The calibration curve was linear over the range of 50.02-175.1 mg·L-1 with a correlation coefficient of 0.999 7(n=6)for metformin hydrochloride,and 0.53-1.855 mg·L-1 with a correlation coefficient of 0.999 4(n=6) for rosiglitazone maleate.The average recovery was 100.1% with RSD of 0.80%,99.56% with RSD of 1.8%,for metformin hydrochloride and rosiglitazone maleate,respectively.Conclusions The determination is not interfered by excipients.The method is applicable to simultaneous determination of metformin hydrochloride and rosiglitazone maleate in compound metformin hydrochloride sustainedrelease tablets.


In this article, we explore the promises of security that are embedded in the smart city technologies and algorithms and their potential implications for creating social inequality and discrimination. Our ethnographic case study is the Living Lab Stratumseind, a popular nightlife street in Eindhoven where smart technologies and algorithms are being tested with the aim of increasing security in the street. First, we introduce the context in which the Living Lab Stratumseind was developed and trace this development and the multiple forms of governance that characterise it and highlight the main 'smart technologies' that can be found there. Second, we focus our attention on the ways in which smart technologies and algorithms promise to enhance public security by directly and uncritically translating technological rationales and discourses into social domains. Third, we argue that the smart city technologies and algorithms risk to create, reproduce and reinforce social inequalities and discrimination, and that it is unclear who is responsible for these unanticipated consequences.