This paper focuses on the ADHD disorders of students between 6-18 years old; the aim of this study is to find out what has been done with advanced technology for students with ADHD. Providing education for Students with learning disabilities is a significant challenge, as these types of students need special learning tools. Attention-deficit/hyperactivity disorder (ADHD) is a common type of disorder which causes learning difficulty and disability. Students with this kind of disorder usually have a limited span of attention, and they are easily distracted. In addition to the possibility of using advanced learning tools for enhancing teaching processes for students with ADHD, this paper evaluates current learning management systems (LMS) that are used in schools and investigates what should be modified in the current (LMS) to make them more helpful for students with ADHD. Research shows that students with ADHD can significantly benefit from the application of ICT tools for academic purposes. Advanced technologies can be used to improve the teaching process for these students through virtual learning; adding a virtual classroom at schools would be very helpful for these kinds of students especially if this classroom is designed well.


Telecommuting, an increasingly popular work mode, blurs the boundary between employees' work and family life. Existing literature suggests that telecommuting enables employees to better manage work and family demands and thus reduces work-family conflict. However, meta-analyses have reported null or small effects of telecommuting on work-family conflict (Allen, Johnson, Kiburz, & Shockley, 2013; Gajendran & Harrison, 2007), suggesting the existence of important moderators. In this study, we argue that telecommuters' work-family integration (WFI) plays an important role in moderating the relationship between telecommuting and work- family conflict. Drawing upon role conflict theory, we propose that telecommuting increases work stress and family stress, and in turn work-to-family conflict and family-to-work conflict, among telecommuters who have a high level of WFI. In contrast, telecommuting decreases work stress and family stress, and in turn work-to-family conflict and family-to-work conflict, among tele...


To reduce the rate of error in gender classification,we propose the use of an integration framework that uses conventional facial images along with neck images.First,images are separated into facial and neck regions,and features are extracted from monochrome,color,and edge images of both regions.Second,we use Support Vector Machines(SVMs) to classify the gender of each individual feature.Finally,we reclassify the gender by considering the six types of distances from the optimal separating hyperplane as a 6-dimensional vector.Experimental results show a 28.4% relative reduction in error over the performance baseline of the monochrome facial image approach,which until now had been considered to have the most accurate performance.


This essay will examine the relations of Roman Catholicism and the New Rome created by Charles the Great in the late 8th and early 9th centuries.1 The Life of Charlemagne by Einhard makes several references to this relation in his sections on conquest as well as the emperor's personal piety. The literature on this essential issue is extraordinarily large. However, the focus of this essay will be on Ganshof's (1965) article "The Impact of Charlemagne on the Institutions of the Frankish Realm." This paper is particularly useful for this essay because it has as its primary concern the Church and its relation to the creation of a new legal order in the west. This article is a perfect companion to Einhard's writings on the empire and religion, since these are orders that were issued from the Emperor both as a political and ecclesiastical figure. There was, in Charlemagne's mind, no distinction between these roles. The church, without strong royal oversight, had decayed under the Merovingian royals, and hence, his role was as extraordinary bishop and monarch simultaneously. Furthermore, these are relevant in his dealings wit the eastern empire (whose title he usurped), as well as, significantly, his desperate Capitulary of Herstal in 779, when the empire seemed to be unraveling. These Capitularies had one theme: the emperor's role was one as churchman and emperor, and, since both have God for their source, they are one.2


This paper summarises the perceptions of stakeholders' roles in enhancing discipline in rural community schools. A mixed research design (qualitative and quantitative) was used in the study. The population was stratified into three- State, Local Government Areas and Rural Communities within the Local Government Areas. A multi-stage stratified random sample of 432 stakeholders was drawn from the six rural communities of Arochukwu and Ohafia Local Governments in Abia State, Nigeria. Semi-structured questionnaires were administered to the stakeholders while structured questions were used for the Focus Group Discussions. The results showed that the stakeholders are in agreement that disciplinary measures are devised to promote and maintain a well-disciplined school environment, quality and equity education (mean = 3.95±0.05); but disagree that the School Board and Parent Teachers' Associations take initiatives in the formulation of school regulations (2.64± 0.06). While management and implementation of discipline jointly significantly (p < 0.05) predicts access to quality and equity Basic Education, the teacher discipline and environment factors are negatively correlated with access to quality and equity in Basic Education. The study recommends partnership between the parents, teachers, school, and the community in addressing issues of the learners' indiscipline in schools. An introduction of modified corporal punishment appropriate to the learners' age and disposition can be implemented to salvage the learners and improve their academic performances.


Objective To explore the dynamic expression of H2AX in alveolar epithelial type cells Ⅱ(AECⅡ)exposured to hyperoxia and its role in lung cells damage induced by hyperoxia.Methods Primary culture of AECⅡ from newborn rat within 24 hours,and after adherenced,the cells were randomly divided into room air group and hyperoxia group.The cells in 2 groups at 6 h,12 h,24 h,48 h after exposure were collected.The expression of H2AX in AECⅡ was detected by immunofluorescence technique,Western blot and real-time fluorescent quantitative polymerase chain reaction.Results Average intensity of H2AX protein in AECⅡ of hyperoxia group was significantly higher compared with that in the room air group at the 6 h and 12 h(Pa0.05),and there was no statistical difference at the 24 h between 2 groups(P0.05),but at the 48 h,it was significantly lower than that in room air group(P0.05).In the hyperoxia group,the H2AX average intensity was decreased with the time of hyperoxia exposure going on(F=62.7,P0.01).The expression trend of H2AX protein and H2AX mRNA were consisted with the result of average intensity,which were the H2AX protein and gene expression of hyperoxia group increased quickly compared with the room air group,and decreased gradually with the length of time exposure to hyperoxia(F=126.6,244.4,Pa0.01).Conclusions Expression of H2AX in AECⅡ increases in early stage of hyperoxia exposure,which is in favour of the repair of DNA damage.But H2AX gradually decreases as prolonged exposure to hyperoxia,which may cause DNA double-strand breaks repair disable and result in cell apoptosis or necrosis.H2AX is closely related to the lung injury induced by hyperoxia probably.


lived experienc*" or "personal" or "account*" or "narrat*" or "story" or "explor*" or "interview" or "case" or "qualitative" or "factor" or "theme" or "thematic" or "interpretative" ALL FIELDS "ethnic minorit*" or "minority ethnic" or "Black" or "BME" or "BAME" or "culture" or "cultural" or "divers*" or "migrant" Table 1: Key search terms By extending out the specific terms of "African-Caribbean" men into terms for "ethnic minority" and removing the term "UK" (amendments to initial review search terms), it was hoped search results might highlight similarity in meaning-making of HV from a minority group perspective, with attention to cultural context. The aim of adding in "lived experience" was to elicit more qualitative research of personal accounts of HV.


In the present study we have synthesized polycrystalline sample of (Nd1/2Li1/2)(Fe1/2V1/2)O3 ceramic by a standard high-temperature solid-state reaction technique. Studies of dielectric and electrical properties of the compound have been carried out in a wide range of temperature (RT - 400 °C) and frequency (1kHz – 1MHz) using complex impedance spectroscopic technique. The imaginary vs. real component of the complex impedance plot (Nyquist plot) of the prepared sample exhibits the existence of grain, grain boundary contributions in the complex electrical parameters and negative temperature coefficient of resistance (NTCR) type behavior like semiconductor. Details study of ac conductivity plot reveals that the material obeys universal Jonscher's power law.


The utility model relates to a gas stove and a control device for being matched with a lampblack machine, which comprises a check sending circuit used for checking whether the gas stove burns, a receiving control circuit used for controlling whether the lampblack machine operates according to a signal sent by the check sending circuit, the utility model is characterized in that the check sending circuit comprises a thermocouple, a first microprocessor and an infrared emitter which are connected in sequence, the thermocouple is arranged at a furnace head of the gas stove; the receiving control circuit comprises an infrared receiver, a second microprocessor and a motor drive circuit which are connected in sequence, the installation position of the infrared receiver is opposite to the infrared emitter, the motor drive circuit is used for controlling a fan motor of the lampblack machine. The opening and closing of lampblack machine of the utility model are determined according to the furnace head flame temperature of the gas stove, the operation of the lampblack machine can be more accurate and reasonable.


Bank investor, acquiror, and investment fund chief John M. Eggemeyer III takes a classical sport fisherman's viewpoint of bank investing. Anyone who has ever done more than dangled a line knows the prime requirement isn't equipment or even bait, but patience. Eggemeyer, head of Castle Creek Capital, Rancho Santa Fe, Calif., made a name early in his bank investing career as a turnaround player, with an emphasis on quick gains from selling rehabilitated institutions. But that is a dated portrait. (Working for another company, Eggemeyer also played a major role in the Chemical Bank acquisition of Chase, before going on his own.) Today, some "fish" Eggemeyer declines to cast for at all--they're not to his taste and never will be. Some he hooks, but then plays them. Sometimes this goes on for years, even a decade or more, Eggemeyer letting them grow to a viable size--with his active help--before he "lands them." When he does so, it's to reap the profits for himself, his team members, and his investors. Buy it and fix it "We make our money as operators," explains Eggemeyer, who, after taking a controlling investment in a bank, often sits on the board or even in the chairman's chair, for a time. Lieutenants and associates often step into key operating slots. "We tend to be very disciplined and focused on what we do. There's no flash and dash about us. We have a particular vision of the industry and we continue to grind it out." Eggemeyer has one more similarity with the fisherman. He always has an eye out for "the big one." And such fish, Eggemeyer waits for, "watching through the weeds," as it were. "You can't be impatient," says Eggemeyer, because there may be only one that is the right fit for his team. "You can say that your number-one priority is to be in the Denver market," says Eggemeyer, "but until that right opportunity presents itself, you may invest in two or three other markets before the opportunity comes along in the market you most want to be in." His kind of town, Chicago is A good example is the Chicago market. Eggemeyer has liked it for some time. It is large, which Eggemeyer prefers. It enjoys a growth rate exceeding the national trend, and has very fragmented, diverse competition. Eggemeyer notes that there are currently more than 200 independent banks in Chicagoland. This combination of factors is ideal for Eggemeyer's preferred methodology. His firm of Castle Creek Capital consists of two main parts, Castle Creek Capital LLC and Castle Creek Financial LLC, plus multiple investment arrangements and relationships. Castle Creek looks for undermanaged banks that can be acquired, or heavily invested in, on a cooperative basis, then revamped. The Eggemeyer touch stresses concentration on business and commercial real estate lending and pushing out high-cost deposits. The initial acquisition is augmented by additional, in-market "rollup" acquisitions that build it to a size and market share that will someday be attractive to a buyer. Eggemeyer and longtime Chicago banker John G. Eck had been talking for some years about a deal they could work together. Eggemeyer wanted to find the right opportunity and Eck wanted to get into the more entrepreneurial side of banking than he was in while at LaSalle Bank, N.A., where he had worked for many years. Eck kept bringing possibilities to Eggemeyer, but nothing clicked. Finally, as Eggemeyer tells it, Eck had to take a banking job to pay the rent. The position he took at Labe Bank, a thrift turned commercial bank of $513.5 million-assets, involved problem loan cleanup. It also entailed helping Labe shift towards more business customers, "which are our bread and butter," says Eggemeyer. Before long, Eck was on the phone. "He called and told me, 'I think I've got the bank for us'," Eggemeyer says. Eggemeyer liked the story this time, and set his hook. …


Objective
To investigate clinical characteristics of severe meconium aspiration syndrome (MAS) complicated with acute lung injury (ALI) and measures for the prevention and treatment of MAS complicated with ALI in order to reduce mortality.

Methods
A total of 56 neonates with a diagnosis of severe MAS complicated with ALI were admitted to our Neonatal Department from September 2009 to March 2011 and divided into two groups based on PaO2/FiO2 level: PaO2/FiO2≤100 group (n=13) and PaO2/FiO2>100 group (n=43). The study protocol was approved by the Ethical Review Board of Investigation in Human Being of Maternal and Child Health Hospital of Xiamen City. Informed consent was obtained from the parents of each participating neonate. No significant differences were found between two groups in the methods of delivery, gender distribution and birth weight of neonate (χ2=1.5, 2.7, 1.9; P>0.05).

Results
Hypoxemia, hypercapnia and decreased lung compliance occurred more serious in neonates of severe MAS complicated with ALI(PaO2/FiO2≤100 group vs. PaO2/FiO2≥100 group)(P<0.001). Chest radiographs commonly indicated pulmonary parenchymal opacities and air bronchograms(χ2=5.28, r=1; P<0.05). These cases required long-term ventilator therapy [(62.15±27.61) h vs. (42.12±19.62) h, P<0.05] and often complicated with persistent pulmonary hypertension of the newborn(PPHN)(P=0.01). The 13 neonates of severe MAS complicated with ALI(PaO2/FiO2≤100 group) were treated with high frequency oscillatory ventilation (HFOV) after admission.Among them, 10 cases(76.9%, 10/13) were treated with PS by endotracheal intubation and 3 (23.1%, 3/13)were treated with inhalation nitrogen monoxide(iNO). After 8-12 hours' treatment with ventilation, arterial blood analysis showed significantly improved oxygenation and alveolar ventilation(P<0.001).

Conclusion
The newborns of severe MAS complicated with ALI showed severe hypoventilation and dysfunction of oxygenation. Combined application of HFOV, PS and iNO strategy can effectively improve oxygenation. But whether it could be the most promising treatment for severe MAS complicated with ALI, it still need multi-center, large-sample random control trials to confirm.

Key words:
meconium aspiration syndrome; acute lung injury; neonate


Objective:To investigate the risk factors for coronary artery lesions in kawasaki disease.Methods:126 children with kawasaki disease were collected.All of the children were divided into two groups according to the results of echocardiogram of coronary artery: one group was children with coronary artery lesions(CAL+)and another group no coronary artery lesions(CAL-).The parameters studied were sex,age,duration of fever,C-reactive protein(CRP),erythrocyte sedimentation rate(ESR),albumine,serum sodium levels and so on.These were examined both in univariate analysis and multiple logistic regression.Results:Among the 126 cases,the complication of coronary artery lesions was 66(52.38%).Univariate analysis indicated that age,the duration of fever,albumine and low serum sodium had significant differences between the two groups(P0.05).Multiple logistic regression analysis indicated age,duration of fever and low serum sodium concentration had close relationship with coronary artery lesions(P0.05).Conclusion:Age1 year,duration of fever prior to treatment and low serum sodium are independent risk factors for coronary artery lesions.


After prolonged treatment with high levels of corticosterone, as in other models of depression, hippocampal atrophy of apical dendrites of CA3c pyramidal neurons has been described. For this purpose, Golgi staining procedure has been used, so the specific intracellular targets of that hippocampal alteration are still unknown. In order to further explore this atrophy, a morphologic analysis of the main hippocampal neuronal populations was made using the immunohystochemistry technique, in rats chronically treated (21 days) with corticosterone. Two doses of corticosterone (100 and 200 mg/kg) were administered by subcutaneous pellet implantation and immunoreactivity of four proteins of neuronal cytoskeleton, NF-68, NF-160, NF-200 and MAP-2, were analyzed in CA3, CA2 and DG areas of the hippocampus. Regardless the hippocampal area, prolonged treatment with high doses of corticosterone produced a significant immunoreactivity decrease of the four cytoskeletal proteins. In order to determine whether these structural modifications had any functional consequence, we studied the in vitro glutamate release. We observed a 30% diminution of the glutamate released from hippocampal slices of rats treated with corticosterone. Thus, we demonstrate that cytoskeletal changes underlie the hippocampal atrophy and that these alterations correlate with functional impairement.


Saline irrigation water is becoming an important water source as fresh water is fast becoming a scarce resource in many areas of the world, including Eswatini, especially in arid and semi-arid regions. A study to test the response of two varieties of spinach (fordhook giant and mustard) to salinity was conducted in a field pot experiment at the Faculty of Agriculture at the Luyengo Campus of the University of Eswatini. The treatments were laid in a randomized block design (RCBD). The experiment consisted of four treatments, each replicated twelve times. Treatments were salinity levels of 0.0 dS/m, 1.5 dS/m, 2.0 dS/m and 3.5 dS/m. All the treatments were subjected to similar agronomic practices. Spinach was grown and observed for a period of five weeks. Plant height was measured and the number of leaves counted weekly throughout the experiment. Significant differences (P < 0.05) between salinity treatments were obtained for plant height beginning in week 2 but were more pronounced in week 3, 4 and week 5. No significant differences were obtained for the number of leaves. There were however, clear significant differences between spinach irrigated with none saline irrigation water compared to saline irrigation water. It was concluded that irrigating spinach with saline water of more than 2.0 dS/m drastically reduce plant growth but not the number of leaves under the conditions of the experiment. Original Research Article Dlamini and Masarirambi; AJAAR, 14(3): 20-26, 2020; Article no.AJAAR.62503 21


The volatile oil of Mentha haplocalyx is widely used in medicine, food and cosmetics. However, a large amount of its residue after steam extraction of volatile oil is abandoned, resulting in a waste of resources. The method of aqueous two-phase flotation coupled with preparative HPLC was established for the separation and purification of non-volatile active compounds from Mentha haplocalyx for the first time. The parameters of the two-phase aqueous flotation were optimized. Under the optimal conditions including flotation solvent PEG 1000 aqueous solution (1:1, w/w), pH 5, (NH4 )2 SO4 concentration of 350 g/L in aqueous phase, N2 flow rate of 20 mL/min, and flotation time of 20 min, the flotation efficiency of linarin, hesperidin, and didymin was 82.24%, 76.38%, and 89.33%, respectively. The linarin and hesperidin with the high purities of 95.8% and 97.2% respectively were obtained by using preparative HPLC. The neuroprotective effect of linarin against H2 O2 -induced oxidative stress in rat hippocampal neurons was investigated. The experimental result indicted that linarin could alleviate H2 O2 -induced oxidative stress. The work indicated that the combination of aqueous two-phase flotation and preparative HPLC is a feasible and practical method for the purification of non-volatile active substances from Mentha haplocalyx, which would provide a reference process for the comprehensive utilization of Mentha haplocalyx. Especially, linarin might be used as a good source of natural neuroprotectants. This article is protected by copyright. All rights reserved.


The studies reported in this paper were undertaken to evaluate the maximum use of lunar in situ resources for surface construction, such as a habitat structure for a permanent manned lunar base. This type of activity is well into the future, but there are possible near-term applications that could utilize in situ resources for protection from radiation of surface power reactors, solar flares, and micrometeorite damage. "Waterless" concrete made of sulfur, a by-product material of oxygen and carbon extractions, is a viable alternative to hydraulic cement. Sulfur–lunar regolith concrete is an ideal material for building structures on the moon. Its availability, high strength, and durability properties make it a very attractive candidate for the development of the first lunar-construction activities. Regolith-derived glass rebar and fiber can also be used with "concrete" made with in situ regolith. Development of such habitats pose tremendous challenges that can be met by the combination of innovative design...


The purpose of this study is to propose a thermal performance evaluation method for passive and low-energy buildings that considers the effects of the residents' behavior. In this paper, first, the purpose and outline of the experiment with subjects are described. Second, the relationship of the thermal sensation votes of subjects (TSV) and previous thermal comfort indices (ET*/SET*/PMV), which is calculated from the environments that subjects were exposed in the experiment, are presented. Third, the predicted thermal sensation votes (PTSV) are expressed as a new comfort index, determined from the experiment. The PTSV was obtained by multiple linear regression analysis with five elements of thermal comfort indices, excluding the quantity of clothes, and adding the effect afterwards. As a result, the PTSV shows similar frequency and tendency to the TSV. Finally, the PTSV comfort zone was compared to three previous comfort zones by changing the condition on the human side, and the tendency of the comfort zone consisting of PTSV was examined. Consequently, the PTSV comfort zone with conditions that are suited to the residents is proposed as the thermal comfort zone in daily life.


(57) Abstract: The present invention relates to novel N- cyanomethyl amides which are cysteine protease inhibitors, their pharmaceutically acceptable salts and their N- oxides, their use as therapeutic agents, and methods for their preparation.


Abstract The current recommendation of the American College of Sports Medicine for proteins is 1.2–1.7 g/kg/day. This recommended protein intake is actually greater than the recommended dietary allowance (RDA) for protein, which is around 0.8 g/kg/day, and is based on several studies that documented increased protein requirement in athletes. Most athletes generally consume more than the recommended protein intake of 1.7 g/kg/day apart from taking amino acid and protein supplements. The current review analyses if the increased protein intake has any beneficial effect on muscle building and performance of athletes, and if there is an optimal time and type of protein for ingestion if this is the case. Studies have shown that high protein intake accentuates renal insufficiency in patients with chronic kidney disease (CKD). We also review if the high protein intake predisposes healthy athletes with normal kidneys and kidney function to any renal problems in the future.


30 In intact adult vertebrates, muscles can be activated with a high degree of specificity, so that even 31 within a single traditionally defined muscle, groups of motor units can be differentially activated. Such 32 differential activation might reflect detailed control by descending systems, potentially resulting from 33 postnatal experience such that activation of motor units is precisely tailored to their mechanical actions. 34 Here we examine the degree to which such specific activation can be seen in the rhythmic patterns 35 produced by isolated spinal motor systems in neonates. We examined motor output produced by the in 36 vitro neonatal rat spinal cord with hindlimb attached. We recorded the activity of different regions 37 within the posterior portion of biceps femoris (BFp; i.e. excluding the anterior/vertebral head). We 38 found that in the rhythms evoked by bath application of 5-HT/NMDA, all regions of BFp were active 39 during extension. However, the regions of BFp were activated in a specific sequence, with the activation 40 of rostral regions consistently preceding those of more caudal regions in both afferented and 41 deafferented preparations. In the rhythms evoked by cauda equina (CE) stimulation, rostral and middle 42 regions of BFp remained active in extension, but the caudal region of BFp was usually active in flexion. 43 Stimulation of L5 and S2 dorsal roots typically evoked rhythms with all regions of BFp active during 44 extension and although the same rostral to caudal sequence of activation observed in 5-HT/NMDA 45 evoked rhythms could also be observed in these rhythms, we also observed cases with reversed 46 sequences, with activity proceeding from caudal to rostral. S2 dorsal root stimulation occasionally 47 evoked rhythms with flexor activity in caudal BFp, similar to CE evoked rhythms. Taken together, these 48 results suggest a high degree of individuated control of muscles by spinal pattern generating networks, 49 even at birth. 50 51 Introduction 52


Mitchell-Riley syndrome is a genetic disorder characterized by neonatal diabetes, pancreatic hypoplasia, intestinal atresia and/or malrotation, biliary atresia, and gallbladder aplasia or hypoplasia. It was considered a variant of the Martinez-Frias syndrome with similar phenotypic characteristics, except for neonatal diabetes and tracheoesophageal fistula. However, the genetic mutation in (regulatory factor X on chromosome 6) RFX6 was only detected in babies who had diabetes, making it different from the previously known mutations for the disease. This is the first reported case of a classical Mitchell-Riley syndrome in the Arab peninsula along with additional features and novel mutations in the RFX6 gene.


Persons living with HIV are at greater risk for many noncommunicable diseases (NCDs) compared with adults without HIV. Using data from NA-ACCORD, a


Atomically thin 2D materials, currently being at the forefront of scientific and technological interest, can be categorized as metallic, semimetallic, semiconducting, insulating, or superconducting...


In this paper, the author discusses how to use problem-based learning (PBL) strategies to improve the teaching of Numerical Analysis in undergraduate mathematics. The current situation of teaching Numerical Analysis in Southern Yangtze University is reviewed with suggestions for change.


Background: The immune system plays a critical part in cancer development and progression. The increase in our understanding of mechanisms regulating immune-mediated cancer eradication has led to the development of immune-based therapies which have revolutionized treatment of some previously lethal malignancies. T-cell activation requires proper intercellular interactions mediated by cytoskeletal rearrangements and adhesion molecules, along with intracellular signal transduction via phosphorylation by tyrosine kinases (Lck and Fyn). Abelson interactor-1 (ABI1) is an adaptor protein known to regulate actin polymerization, adhesion molecules and tyrosine kinases. Previously, ABI1 has been shown to localize to the immunological synapse in an antigen-dependent manner and has been linked to regulation of IL-2 secretion. Published data from our lab shows that ABI1 has high affinity binding to SH2 domains of Src family kinases, Fyn and Lck, both of which are essential in T-cell activation. Additionally, ABI1 has been linked to hyperactivation of SFKs/STAT3/NF-kB signaling. In this study, we aim to delineate the role of ABI1 in T-cell activation, differentiation and signaling.
 Methods: We have generated a novel conditional knock-out mouse model to evaluate the effect of a T-cell specific ABI1 KO at the organismal level (ABI1(fl/fl)CD4Cre (ACD4). T-cells isolated from control (Abi1(fl/fl)CD4Cre(-)) and ABI1 KO mice (Abi1(fl/fl)CD4Cre(+)) were used for ex-vivo analysis and further characterization of ABI1 KO cellular phenotype with: Flow Cytometry (CD3+ subpopulations in immune organs), Immunofluorescence (actin polymerization), Western blotting (TCR-mediated T-cell activation) and RNAseq (transcriptional reprogramming). Results: In vitro studies of ABI1 KO primary murine CD3+ T-cells showed increased levels of NF-kB and STAT3. Flow cytometry analysis of CD3+ T cells subpopulations showed a difference in the percentage of CD4+ and CD8+ T cells; percentage of CD8+ T cells was increased, while percentage of CD4+ T cells was decreased in ABI1 KO vs. WT control mice. Furthermore, RNA seq analysis of CD8+ ABI1 KO T cells showed a significant decrease in the mRNA expression of Thpok (Zbtb7b) compared to WT.
 Conclusion: Our preliminary studies show that ABI1 is a potential modulator of T-cell activation through regulation of Lck/Fyn. This suggests ABI1 may play as a molecular switch negatively regulating T-cell activation by connecting phosphorylation-dependent signal transduction and actin cytoskeletal dynamics. Suggesting ABI1 as a new therapeutic to improve efficacy and longevity of T cell-based cancer immunotherapies. In addition, ABI1 appears to be implicated in the regulation of the percentage of CD4 and CD8 T-cells, a novel discovery which warrants further investigation.
 Citation Format: Maria Altagracia Ortiz, Andras Perl, Marcin Kortylewski, Leszek Kotula. Characterization of mouse and cellular phenotype of ABI1 KO T-cells [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 2097.


Abstract 1. The effects of starvation on glyceride synthesis have been studied in biopsies of human adipose tissue. After a week's fast glyceride synthesis from glucose (8.3 and 14 mM) was reduced by about 70% in intact adipose tissue; this occurred within 5 days of starting the fast.—2. A method has been devised to follow the simultaneous incorporation of 14C‐l‐palmitate into acyl‐CoA, phospholipid and neutral lipid in homogenates of human adipose tissue. This system was sensitive to fluoride which produced an accumulation of radioactivity in phospholipid and a reduction in neutral lipid.— 3. Starvation also reduced the incorporation of 14C‐l‐palmitate into neutral lipid in a similar incubation system, but radio‐activity now accumulated in long chain acyl‐CoA. This suggests that fasting is accompanied by an inhibition of L‐glycerol 3‐phosphate acyl transferase (E.C. 188.8.131.52).—4. Oleate (600 μM), which is similar to concentrations found in homogenates of fasting adipose tissue, was found to inhibit the activity of acyl transferase by about 80%. The possibility was therefore considered that the reduction of lipogenesis during fasting is mediated by free fatty acid inhibiting the acyl transferase.


Librarians and scholars alike have long lamented the lack of a compre hensive bibliography of theological and religious reference materials . The wMt is over, and it was worth it. Not only have the Gormans pro duced a comprehensive bibliogra phy, they have annotated it as well, making it one of the most useful ref erence tools ever to enter theological realms. Originally intended to be a single volume (approximately 400 pages) work, TRRM is now projected to be complete in four volumes, total ling nearly 2,000 pages.


This paper presents some studies on prime feed reflector antennas system using the dual-grid BoR-FDTD approach. The technique requires two consecutive simulation steps, where the stored data from the first simulation can be repeatedly used in the second simulation domain. This offers fast parametric study involving the feed structure to study its effect on overall antenna performance. Based on this study, antenna gain could drop by more than 1 dB if the feed position shifted > 0.5λ0 from the reflector's focal point. The blockage due to feed structure does not significantly affect the radiation pattern performance for parabolic reflector system. However, for spherical reflector, the blockage effect is much notable.


The trade secret as a technique of commercial competence demands the fulfillment of a series of requirements in order to supervise it. One of them is the adoption of protective measures. For this purpose, different criteria were established for the appreciation of the reasonableness in the choice of such measures. The objective of this study was to examine the Spanish thesis of the two spheres of protection of secret. The methodology used was the descriptive documentary juridical research using the technique of critical analysis. In this work it is concluded that the thesis in question exhibits a solution based on the fundamentals of trade secret that can be standardized as a guideline.


Abstract: The goal of this Thesis was to get digitalised the subsurface model of the Karlovac subdepression, part of the Sava depression. Input data for modelling were previously constructed structural maps made in 80's which were based on geological and geophysical data from that time. Six maps of E-log-defined contacts and E-log markers (Tg, Rs7, Rs5, Z, Rφ and α) existed. Size of the digitalisation area is 1084 km2. The first step was geolocation and feature digitalization of those maps in Arc GIS 10.1 and afterwards modelling in the PetrelTM 2014. The result was a model which represents geological structures, E-log horizons, surfaces as well as fault planes. In the end the percentage of error was calculated between handmade and digitalised maps, which is 4.682%. The advantage of digitalised model in comparison with previous interpolation is getting a 3D data of the subsurface, which is necessary for further modern exploration.


We calculate optimal portfolio choices for a long-horizon, risk-averse European investor who diversifies among stocks, bonds, real estate, and cash, when excess asset returns are predictable. Simulations are performed for scenarios involving different risk aversion levels, horizons, and statistical models capturing predictability in risk premia. Importantly, under one of the scenarios, the investor takes into account the parameter uncertainty implied by the use of estimated coefficients to characterize predictability. We find that real estate ought to play a significant role in optimal portfolio choices, with weights between 10 and 30% in most cases. Under plausible assumptions, the welfare costs of either ignoring predictability or restricting portfolio choices to financial assets only are found to be in the order of at least 100 basis points per year. These results are robust to changes in the benchmarks and in the statistical framework. JEL Classification Codes: G11, L85.


Sepsis its complications are a major public health problem in the world. Tissue hypoperfusion as a result of peripheral vasodilatation, capillary leak syndrome, myocardial depression, activation of the coagulation cascade and release of proinflammatory cytokines are the basis for the development of multiple organ dysfunction and death. In this paper, the authors present an updated review of the pathophysiology, biomarkers and treatment focused attention on the Emergency Services.


Noni, botanically known as Morinda citrfolia L, a miracle plant with more than 150 nutraceuticals were found growing naturally in all types of lands right from sea coast to interior and are now being cultivated as crop by the farmers of India. While its cultivation and medical significance is gaining popularity, it is important to understand various challenges, limiting factors and biotic stresses that the crop encounters. Extensive cultivation of noni has resulted in severe outbreak of pests and diseases such as aphids, thrips, mealy bugs, leaf blight, anthracnose, black flag, fruit rot, stem blight, sooty mold, stem canker and algal leaf spot. Root-knot nematode, Meloidogyne incognita is one of the most damaging pathogens infesting the crop at the seedling stage in the nursery and carried to the main field. The research and development work carried out in India and elsewhere, and so an attempt is being made to review the available literature and presented here.


Development of a distance education platform of the surgical anatomy of the equine locomotor apparatus as a complementary tool for training in veterinary surgery . There are currently several difficulties in teaching veterinary anatomy, exemplified by the time available in the classroom, costs and difficult access to animal corpses for reasons related to animal welfare. Furthermore, other difficulties arise, such as the lack of anatomical knowledge in recent graduates, reported by surgeons and radiologists. On the other hand, the current limitations of face-to-face teaching due to the COVID-19 pandemic suggest that the development of distance education tools is necessary, mainly in specialties that lack this type of material available "online". Teaching platforms promoting the integration of anatomy with other applied disciplines such as imaging and surgery in the equine species were not found in the consulted literature. Therefore, this work aimed to develop a distance education platform in "Surgical Anatomy of the Locomotor Apparatus in Horses" as a complementary tool for the training of students enrolled in undergraduate courses in veterinary surgery. For this purpose, it was carried out an analysis of the casuistry of the large animal surgery service of the Veterinary Hospital of the Faculty of Veterinary Medicine and Animal Science of the University of São Paulo, and the locomotor apparatus was chosen as the focus of the platform as it is the most affected in equine surgical routine. anatomical pieces referring to the locomotor apparatus of the equine species were prepared. These were complemented with diagnostic material related to diagnostic imaging, surgery videos, theoretical explanations, and an interactive radiological anatomy tool. Finally, all the material created was gathered on a virtual platform accessible on the internet and hosted on the website anatocxequino.com. It is expected that the developed platform will be a tool that helps students in surgical training and makes them veterinarians with a better understanding of anatomy and its application in surgery, especially in the current pandemic situation.


The Cold Plasmas otherwise called the non-thermal plasmas is an emerging branch of plasma science utilizing the effectiveness of ionized gases produced by the resistive barrier plasma discharge on sterilizing bacteria has been analyzed. Bacteria at a dilution that achieved a countable number of colonies were exposed or not exposed to ionized gases for various periods of time and monitored to determine the effects of ionized gas treatment. The results of these experiments indicate that effective decontamination can be achieved within minutes when bacteria are exposed to ionized gases in close contact to the contaminating surface. On the battlefield or in remote locations, ionized gases could be used to decontaminate potentially harmful agents of bacterial origin. In hospitals on the battlefield and/or in remote locations, ionized gasses could be used to sterilize surgical equipment, decontaminate potentially infected areas in post-operative care units following surgery. In such cases the self-generated gas flow from the reactor facilitates the application of the ionized gases over the large infected areas.


Background: Altered cardiovascular autonomic nerve function with impaired sympathovagal balance is found in rheumatoid arthritis (RA). Heart Rate Variability (HRV) analysis is an important tool for assessment of autonomic nerve activity. Objective: To assess cardiac autonomic nerve function status in patients with Rheumatoid arthritis (RA) by time domain measures of HRV. Methods: This cross sectional study was conducted in the Department of Physiology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka from January to December 2010. Sixty female RA patients, age range 18-50 years were constituted study group enrolled from the Out- patient Rheumatology Wing, Department of Medicine, BSMMU. Age matched thirty apparently healthy females were studied as control. Time domain measures of Heart Rate Variability (HRV) such as Mean RR intervals, Mean HR, SDNN, RMSSD, NN50% and PNN 50% were recorded for 5 minutes by a Polygraph machine to observe cardiac autonomic nerve function activity. Data were analyzed by independent sample t test. Results: Mean R-R interval, SDNN, RMSSD, PNN50%, NN50% were significantly lower (p<0.001) but heart rate was significantly (P<0.001) higher in rheumatoid arthritis patients. Conclusion: Cardiac autonomic nerve function is impaired and characterized by reduced resting parasympathetic activity in female Rheumatoid Arthritis patients. DOI: http://dx.doi.org/10.3329/jbsp.v7i2.14455 J Bangladesh Soc Physiol. 2012, December; 7(2): 78-82


Quadrotor unmanned aerial vehicles (UAV) as a typical under-actuated system, which has strong coupling, nonlinear and other characteristics. an sliding mode sliding mode event-triggered control method is proposed to deal with the external disturbance and limited communication. Firstly, the dynamic characteristics of the quadrotor UAV is analyzed, then the time-scaling techniques is applied to decouple the system into the position sub-system and the attitude subsystem. Secondly, the position subsystem is transformed into strict feedback form, and a backstepping sliding mode controller is designed to implement the trajectory stability tracking. In order to deal with the case of bounded disturbance and communication restricted, an event-triggered control law based on sliding mode control is designed to achieve the virtual attitude command tracking while suppressing the disturbances. The stability of the proposed controller is proved based on Lyapunov method, and the closed-loop control system does not appear Zeno phenomenon is proofed by theoretical analysis. Finally, simulation results are given to demonstrate the trajectory tracking robustness of the sliding mode event-triggered control law with respect to external disturbances and communication restricted of a quadrotor UAV.


The Nutrition and Physical Activity Program to Prevent Obesity and Other Chronic Diseases of the Centers for Disease Control and Prevention uses a Social-Ecological Model (SEM) as a framework for examining the problem of childhood overweight and obesity (Hamre et al., 2006). Trim Kids (Sothern, von Almen, & Schumacher, 2001) is a program aimed at improving the health status of children and includes elements at the individual, interpersonal and organizational levels. In this study, data from eleven sessions of the Trim Kids program were examined to determine the effectiveness of the program in improving weight status as indicated by reductions in mass, BMI, BMI-for-age percentile or waist circumference. Statistically significant reductions were detected for BMI with small effect sizes in all variables. The results of this study suggest that increases in stature may have been more influential than reduction in mass in reducing BMI. Trim Kids and other behavior-change programs would benefit from recording stature data as a critical component in tracking weight status in children. Trim Kids is a program that does not require expert leadership or expensive equipment and may have benefits in engaging families and slowing the progression of obesity.


We establish here that under some simple restrictions on the functional coefficient a(t) the solution set of the fractional differential equation (0Dαtx)′ + a(t)x = 0 splits between eventually small and eventually large solutions as t → +∞, where 0Dαt designates the Riemann–Liouville derivative of the order α ∊ (0, 1).


This tutorial is intended for researchers and developers who are working on Computer Assisted Technology (CAT), and want to know more about how translators do their work, and what they need from such technology. It will teach them how to acquire such knowledge using a simple Human Computer Interaction Technique (HCI) called Contextual Inquiry. Contextual Inquiry is a well-known, mature technique (Beyer and Holtzblatt, 1998), where researchers observe and interview potential endusers while they are involved in their normal day to day work. One advantage of this technique, compared to other requirement elicitation methods, is that it is generative. Instead of just asking endusers what they think they need (which often turns out to be different from what they actually do need), researchers aim for a deep understanding of important details of the end-user's world. This intimate knowledge can then be leveraged to design new and possibly disruptive technologies and processes, which are nevertheless well grounded in actual end-user needs and context, and have therefore a greater chance of being adopted. The presenters of this tutorial have been using this technique in the context of several Computer Assisted Translation technology projects, and have found it to be invaluable (Désilets et al, 2008). The tutorial will be highly interactive and allows attendees to get hands on experience with the technique, by observing an actual translator doing her normal work. Attendees also get to ask probing questions, and collectively analyze what they saw and heard during the interview, in terms of what it might mean for CAT development. For many developers and researchers in the audience, this may be their very first exposure to the work of actual end-users of their technology, and this in itself, has been shown to produce long-lasting and valuable changes in developers attitudes towards end users (Beyer and Holtzblatt, 1998).


Although the west façade of Wells Cathedral has been carefully studied, a series of problems concerning its date, original form and meaning remain. This paper focuses on the archaeology of its central portal, featuring the Coronation of the Virgin. Working from the archaeological evidence, it offers a reconstruction of the portal which leads to a broader consideration of the place of the imagery in British and European medieval art. This informs an exploration of the meanings of the façade as a whole within the context of then current commentaries on the Song of Songs in France and England.


Although blessed with abundant solar and wind energies, North Africa has yet to maximise its socioeconomic gain from tapping these resources. In view of North African demographic and middle class expansion, energy demand is set to increase. Tapping renewable energy sources will not only address these problems, but also will be an impetus to the faltering socioeconomic dynamic the region needs to boost sustainable development to benefit from globalisation. However, with bureaucratic-laden institutions and corruptions hindering the private sector from flourishing, governments are compelled to mobilise public finances to cover the lack of private investments in renewable energy projects. Increasing investments in education and R&D to meet skills demand for renewable energy projects that continues to lag behind foreign contents as the primary input. Skills mismatch between the labour force and technology intensive renewable energy industry is a result of the people's aspiration and desire to work for the government shaped by post-independence policies. The challenge for North Africa policy makers is beyond correcting institutional deficiencies to transform its business environment, but also to influence change in the perception and attitude of the public.


The saturated vapor pressures of myrac aldehyde and lyral were measured by static method at 368.65-409.35 K and 391.85-416.35 K respectively.They were correlated by Antoine equation,with three parameters obtained as A=-4.159,B=2 494.037,C=-626.842 for myrac aldehyde,and three parameters obtained as A=10.701,B=558.048,C=-296.730 for lyral.Isobaric vapor-liquid equilibrium data of the binary system of myrac aldehyde and lyral were measured at 321 Pa and 423 Pa by Rose still and were confirmed by thermodynamic consistency check.Wilson and NRTL models were used to correlate the experimental data and vapor composition and temperature were calculated with model data.The average deviation between the correlated values and the experimental data of gas mole fraction is lower than 0.009 0 and 0.003 4,respectively.The data can be used for building the mathematical model of separating myrac aldehyde and lyral.


Curcumin has been proven to effectively inhibit tumor growth by both targeting tumor cells and angiogenesis; however, poor water solubility limits further clinical application. In the present study, we prepared water-soluble liposomal curcumin to investigate its anti-tumor effects and the underlying mechanism. The MTT assay was used to test the anti-proliferative activities for the MS1 murine endothelial and LL/2 Lewis lung cancer cell lines. Apoptosis and cell cycle arrest induced by liposomal curcumin were analysed by flow cytometry. Anti-angiogenic agents and the resulting anti-tumor effects were investigated in a murine lung cancer model. Zebrafish were used to investigate the anti-angiogenic effect of liposomal curcumin in the development of embryos. In vitro, liposomal curcumin inhibited the proliferation of MS1 cells and induced cell cycle arrest and apoptosis. Notably, LL/2 cells showed less sensitivity to the liposomal curcumin in vitro. In vivo, the systemic administration of liposomal curcumin resulted in significant inhibition of tumor growth. CD31 immunohistochemical analysis and alginate encapsulation assay revealed that angiogenesis was decreased by liposomal curcumin treatment. Angiogenesis was also suppressed in the development of zebrafish. Liposomal curcumin showed potent inhibitory activity against murine endothelial cells but not lung cancer cells. Liposomal curcumin treatment is capable of significantly inhibiting tumor growth in vivo, a process that may depend primarily on its anti-angiogenic effects. Our study also indicates that liposomal curcumin may be developed not only for cancer therapy, but also for the treatment of other angiogenesis-related diseases.


For three weeks in October 2009, the U.S. Department of Energy hosted the Solar Decathlon Competition in which 20 teams of college and university students competed to design, build, and operate their own version of a solar-powered house. Team North's mission was to deliver North House, a compelling, marketable solar powered home for people with active lifestyles, while building Canada's next generation of leaders in sustainable engineering, business and design. This paper deals with a solar-assisted space heating system that was studied as a potential design for the competition. Among several other conclusions, it was found that using a solar-assisted in-floor heating system can decrease the energy consumption to only 8% of the case without the in-floor loop.


Guided with the theory of high resolution sequence stratigraphy and based on cores,well logs and seismic materials,the sequence stratigraphic scheme of the Member 4 Quantou Formation to Yaojia Formation in Haituozi-Dabusu area has been constructed,which is composed of 5 long term base level cycles(third order sequence)and 9 middle term base level cycles(fourth order sequence),and the sequence stratigraphic framework has been discussed.The result shows that turbidite sand body and distributary channels of delta front mainly develop at the half cycle increasing period and mouth bar,distal bar and sheet sand of delta front mainly develop at the half cycle decreasing period.The turbidite sand body and distal bar,sheet sand of delta front are favorable reservoirs in the study area.


Many circulating biomarkers are assessed at different time intervals during clinical studies. Despite of the success of standard joint models in predicting clinical outcomes using low-dimensional longitudinal data (1-2 biomarkers), significant computational challenges are encountered when applying these techniques to high-dimensional biomarker datasets. Modern machine- or deep-learning models show potential for multiple biomarker processes, but systematic evaluations and applications to high-dimensional data in the clinical settings have yet to be reported. We aimed to enhance the scalability of joint modeling and provide guidance on optimal approaches for high-dimensional biomarker data and outcomes. We evaluated multiple deep-learning and machine-learning models using 24 clinical biomarkers and survival data from the SQUIRE trial, a phase 3 randomized clinical trial investigating necitumumab and standard gemcitabine/cisplatin treatment in patients with squamous non-small-cell lung cancer (NSCLC). Overall, we confirmed that longitudinal models enabled more accurate prediction of patients' survival compared to those solely based on baseline information. Coupling multivariate functional principal component analysis (MFPCA) with Cox regression (MFPCA-Cox) provided the highest predictive discrimination and accuracy for the NSCLC patients with AUC values of 0.7 - >0.8 at various landmark time points and prediction timeframes, outperforming recent advanced Transformer and convolutional neural network deep-learning algorithms (TransformerJM and Match-Net, respectively). In conclusion, we identified that MFPCA-Cox represents a robust and versatile joint modeling algorithm for high-dimensional biomarker longitudinal data with irregular and missing data, capturing complex relationships within the data, yielding accurate predictions for both longitudinal biomarkers and survival outcomes, and gaining insights into the underlying dynamics.


Glutathione is a valuable tripeptide that is widely used in the pharmaceutical, food, and cosmetic industries. Glutathione is industrially produced by fermentation using Saccharomyces cerevisiae. Before the glutathione fermentation process with S. cerevisiae, a glucose extraction process from starchy materials is required. This glucose extraction is usually carried out by converting starchy materials to starch using high‐temperature cooking and subsequent hydrolysis by amylases to convert starch to glucose. In this study, to develop an energy‐saving glutathione production process by reducing energy consumption during the cooking step, we efficiently produced glutathione from low‐temperature cooked rice using amylase‐expressing S. cerevisiae. The combination of the amylase‐expressing yeast with low‐temperature cooking is potentially applicable to a variety of energy‐saving bio‐production methods of chemicals from starchy bio‐resources.


THE Cave Swallow (Petrockelidon fulva) previously has been thought to be isolated ecologically from other hirundinids in Texas, narrowly restricted in its breeding sites to sinkholes and the twilight zones of caves (Selander and Baker 1957, Whitaker 1959, Baker 1962, Reddell 1967, see Wauer and Davis 1972 for isolated exceptions). Recently its spatial relationships have changed: P. fulva has expanded its breeding niche in the United States to include habitats altered by human activity and has entered into more intimate contact with other swallows. Preliminary to a detailed analysis of distribution, reproductive biology, and interspecific relationships in culvert-nesting Cave and Barn Swallows (Hirundo rustica), this report details their extensive synchronous and syntopic reproduction in south central Texas.


Dalai Lama and Howard Cutler The Art of Happiness at Work London: Hodder& Stoughton, 2003Reviewed by Raymond A. LemayIn the public sector and in human services particularly, human resources - employees - are the means to the end. The old Defasco steel ad slogan told us "Our product is steel. Our strength is people" and, in the public sector where the product is the crafting of the public good, the adage about the people is likely more critical. So what about our people? Are they well enough to be the strength of the system that guarantees the public good? Recent surveys (AOL, 2011; Barrows & Wesson, 2001; Burch and Axworthy, 2010) suggest that not all public servants are satisfied with their roles, and these authors recommend systemic change, suggesting that the employer must reform its human resource practices. Organizational, employee and workplace "wellness" are strategies that put the onus on the employer to create work conditions that promote healthier and happier employees."If there is injustice, then I think inaction is the wrong response."- The Dalai LamaIt would seem, however, that the Buddhist tradition, without refuting the possibility of systemic reform, would view such problems from a different and more personal perspective. The Dalai Lama and Howard Cutler weigh in on the issue of employee happiness in a different and interesting way.The authors of this book had previously collaborated in 1998 on the book The art of Happiness: A Handbook for Living, the purpose of which was to convey to novices the basics of Tibetan Buddhist psychology:* The purpose of life is happiness.* Happiness is determined more by the state of one's mind than by one's external conditions, circumstances, or events - at least once one's basic survival needs are met.* Happiness can be achieved through the systematic training of our hearts and minds, through reshaping our attitudes and outlook.* The key to happiness is in our hands (p. 1).In this book they particularize the teaching to work; happiness at work is bound to have an impact on one's life more generally: we spend a lot of time at work, and Cutler quotes researchers (Harter, Schmidt and Corey Keyes, 2003) who report that "as much as a fifth to a quarter of the variance in adult life satisfaction can be accounted for by satisfaction with work" (p. 188: NB: all page references are to work under review).The book, however, focuses only on the individual worker, "happiness at work generally from the standpoint of the worker, the employee, and measures they can take to become more satisfied at work through their own efforts, by changing their outlook, increasing self-understanding...." (p. 206). The Dalai Lama adds that this "is only part of the picture. The employer also, the management, the organization, all plays a role in setting the tone of the workplace environment, and have an impact on the happiness of the employees, and of course if we are to discuss wider issues of ethics in business, the economy, and so on, that is another thing..." (p. 206)The book's nine chapters discuss various sources of (un)happiness at work and the Dalai Lama proposes ways to address and rectify sources of unhappiness.Transforming Dissatisfaction at WorkThere are many sources of dissatisfaction at work, but a good place to start is with oneself, and one's attitude. If one doesn't like a job, then one should change and get another job, or alternatively develop an attitude of contentment. There are undoubtedly worse jobs, and more trying situations. Indeed, one should come to the realization that there are a myriad of factors that make a job satisfying or not. Some of these factors (indeed many) are simply beyond our (or our boss') control. Cutler asserts that the Dalai Lama has an "unsentimental" (p. 33) view of life difficulties:There will always be problems in life. It is just not possible to go through life without encountering problems. …


Word processing is an activity performed more and more frequently, though it has only a marginal role in teaching and learning computer science. In the curricula, it appears briefly as a technical issue, e.g. learners have to study the kinds of menues and icons included (typically and only) in MS Word, and what these menues do in actual application. Nevertheless, word processing is much more than applying some icons and menues in a word processor. Aesthetic documents can be made through collaboration in typography, design, grammar and – last but not least – the word processor or the typesetting program. An e-learning course is under construction on word processi ng, called TOT"M. The course inludes four main fields: typographical recommendations, design samples, important grammar rules and programing in TEX. This e-learning course can be used in blended courses and dis tance education in lifelong learning and lifewide learning studying word processing or TEX. It can be used as on-line help in word processing. This presentation tacjkles the main objectives of TOT"M, its knowledge base, the connections of the four fields and treats some pedagogical aspects of e-learning and features applied in the system.


We consider the solution operator S : Fμ,(p,q) → L (μ)(p,q) to the ∂-operator restricted to forms with coefficients in Fμ = { f : f is entire and ∫ n |f(z)| 2 dμ(z) < ∞ } . Here Fμ,(p,q) denotes (p, q)-forms with coefficients in Fμ, L (μ) is the corresponding Lspace and μ is a suitable rotation-invariant absolutely continuous finite measure. We will develop a general solution formula S to ∂. This solution operator will have the property Sv ⊥ F(p,q) ∀ v ∈ F(p,q+1). As an application of the solution formula we will be able to characterize compactness of the solution operator in terms of compactness of commutators of Toeplitz-operators [Tzi , Tzi ] = [T ∗ zi , Tzi ] : Fμ → L (μ).


Although women typically report using health services more frequently than do men, the reason for this difference is unclear. According to the "fixed role hypothesis," women report greater use of health services because, in the aggregate, they have fewer work and time constraints on their behavior, thus making it easier for them to reschedule activities in order to visit a doctor. Examining data from the 1976-1977 Los Angeles Health Survey, the proportion of chronic problems resulting in a self-reported doctor contact was initially 1/ percent higher for women (N = 988; p < .00/). As predicted by the fixed role hypothesis, controlling for differences in fixed roles (particularly employment status) reduced this differential to a nonsignificant 5 percent. No sex differences were found in reports of using health services for acute illness (N = 628). These findings suggest that the fixed role hypothesis may be most appropriate for explaining sex differences in behavioral responses to chronic symptoms.


We study electron spin transport at spin-splitting surface of chiral-crystalline-structured metals and Edelstein effect at the interface, by using the Boltzmann transport equation beyond the relaxation time approximation. We first define spin relaxation time and spin diffusion length for two-dimensional systems with anisotropic spin--orbit coupling through the spectrum of the integral kernel in the collision integral. We then explicitly take account of the interface between the chiral metal and a nonmagnetic metal with finite thickness. For this composite system, we derive analytical expressions for efficiency of the charge current--spin current interconversion as well as other coefficients found in the Edelstein effect. We also develop the Onsager's reciprocity in the Edelstein effect along with experiments so that it relates local input and output, which are respectively defined in the regions separated by the interface. We finally provide a transfer matrix corresponding to the Edelstein effect through the interface, with which we can easily represent the Onsager's reciprocity as well as the charge--spin conversion efficiencies we have obtained. We confirm the validity of the Boltzmann transport equation in the present system starting from the Keldysh formalism in the supplemental material. Our formulation also applies to the Rashba model and other spin-splitting systems.


It is shown that the problem of evaluating an Nth degree polynomial is reducible to the problem of dividing the polynomial. A method for dividing an Nth degree polynomial by an N/2 degree polynomial in O(N log 2N) steps is given. Using this it is shown that the evaluation of an Nth degree polynomial at N points can be done in O(N log 3N). The related problem of computing of computing the resides of an N precision integer is handed by the same algorithm in O(N log2N loglogN) steps. Using the methods of Horowitz11 and Heindel8 it is shown that interpolation of an Nth degree polynomial is redicible to the problem of evaluating an Nth degree polynomial at N points. An algorithm for preconditioned polynomial interpolation requiring O(N log 2N) steps is presented. This is then extended to perform the complete interpolation in O(N log 3N) steps. A modified version of Reminider Problem in O(N log 2N loglogN) steps.


. The goal of paper to see that different models for spiral pattern of galactic disks lead to distinguishable radial distribution of heavy elements. Moreover it will be explained why the distributions, demonstrated different chemical elements show dif-ferent pattern. This fact has extremely importance for understanding of the processes, which occur in a galactic disk and allows to narrow down the possible class of their models.


Despite being a recurring type of sequence variation, amino acid insertions and deletions (InDels) and their resulting functional significance remain a rather unexplored area of structural biology. InDels are quite often the driving force behind many diseases. Despite that, modeling InDels and exploring their functional implications remains lacking, mainly due to the dearth of experimental information and computational methodologies. In this work we introduce an algorithmic approach to model short InDels in silico and explore the structural and rigidity differences between the wildtype and the mutant protein structures. We assess rigidity to gather useful information about the protein's general structure, the location of flexible and rigid clusters, and to permit a visual analysis of the effects of InDels local to the mutation site. Our results show that our method can efficiently create a computer-generated mutant that is functionally similar to the experimental mutant at both the local region of the InDel, as well as on the entire protein scale. The results show promise in our ability to accurately predict the effects of short insertions and deletions on the structural properties of proteins.


Cavill et al. have produced data which agree with the estimate of McSwiney and Woodrow (1969)-'. . . approximately 3 % of everything that one does is a mistake even with very careful organization'. But is the conclusion of Cavill and his colleagues-stop telephoning results on request-the correct way to reduce this error? I do not believe so, and I find it hard to understand how a white cell count of 'three point six', to take one of their examples, could be read back as 'three eight point zero' or 'thirty eight', Welsh accents notwithstanding. McSwiney and Woodrow (1969) stressed the need to double check, and I would suggest that the double checking drill used in Cardiff needs to be re-examined. I (Henderson, 1977) previously suggested that the name of the person taking the laboratory result should be recorded, as the efficiency of the process increases when accountability rears its head! The fact that Cavill et al. are asked to telephone so many results suggests that their routine means of communication with the wards is basically unsatisfactory. I (Henderson, 1979) bemoaned the fact that we, at University Hospital, were not asked often enough to telephone nonpriority results when they were ready, but this maybe is because we issue computercompiled interim laboratory reports up to five times during the day from 0700 until 2200. Of course we are all asked, unreasonably, to provide results quickly, but if even a small proportion of these results are really needed for good patient care I believe that we have to grin and bear the consequences. Until we all get equipped with visual display terminals on every ward connected with the laboratory computer, telephoning is still the most convenient method of transferring data rapidly and easily, if not always exactly.


Background: Type 2 Diabetes is the most common form of diabetes mellitus, accounting for 90% of all types of diabetes. Diet is one of the important factors affecting the progression of the disease.
Methods: In this study, we used urinary protein profile to evaluate the progression of pre-diabetic to diabetic state. Urinary protein profile of pre-diabetic rats with various diet conditions and with or without metformin treatment were compared to those of healthy rats and diabetic rats.
Results: It was shown that there were distinct bands that could differentiate the healthy rats from the diabetic ones, namely the protein bands at MW 350 kDa, 280 kDa and 85 kDa (for healthy rats), and protein bands at MW 170 kDa, 51 kDa and 46 kDa (for diabetic rats). In addition, the differentially excreted proteins at MW 62 kDa and 25 kDa (between healthy and diabetic rats) could also be used as indicators. Using the unique band indicators, the pre-diabetic urinary profile was shown to be similar to that of healthy rats. However, by using the differential protein indicators, the band intensity of the 62 kDa, 25 kDa and 17 kDa bands of pre-diabetic rats, with normal diet and metformin treatment, was more similar to that of the healthy rats with normal diet. However, the profile of pre-diabetic rats with high fat diet (with or without metformin treatment) and of pre-diabetic rats (with normal diet without metformin treatment) were more similar to that of diabetic rats.
Conclusion: Using this protein profiling comparison method, it was demonstrated that early metformin treatment and controlled diet intake are important in delaying the progression of the pre-diabetic to diabetic state.


A model for fatigue crack propagation with bridged fibers has been developed. It is based on linear fracture Mechanics combined to determination of the closure pressure exerted by the fibers, that reduces substantially the matrix crack growth. Two scales have been modeled to obtain the bridging effect expression. At the lower scale, pertinent interfacial properties have been described such as debonding and friction. Furthermore, an application is proposed from a fatigue test on SiC/Ti. It has been performed on a center-notched specimen from which the crack growth has been accurately calculated. The abilities of this model are in agreement with the different experimental stages. It offers promising prospects to find optimal interfacial properties and to establish a propagation law for bridged cracks.


Based on the specific morphology of pupilLary smooth museles , a contTQI model for pほpillary light reflex was der主Ψ ed. △performance 呈ロdex was forrnula 亡ed, assumirIg that the pupil was control 工ed to react quickly and smoothly , The optima 玉 呂olution derived by Euler −Lagrange quatlon was highly correlated with exp θrintental data of pupil behavior. Moreover、 the mOdel was fitted to tbe oha 皿ges of observed pupil diameしers befare and after mental york −IQad, for the purpose of quantitative esti − mation of Ψisロal fatigue. The derived parameters expressed the activities o£ the a 巳tono 旧 1c nerVDus sys しem.


................................................................................................................................................... I ACKNOWLEDGEMENTS ............................................................................................................................. V LIST OF FIGURES .................................................................................................................................... XIII LIST OF TABLES ..................................................................................................................................... XIV ABBREVIATIONS ..................................................................................................................................... XV CHAPTER 1: INTRODUCTION AND OVERVIEW OF THE STUDY ......................................................... 18 1.


The study deals with a material survey and determination of the corrosion character of a Roman bronze vessel from an early Tiberian period. The ancient technology of the bronze vessel production was determined based on the evaluation of structural properties of the material using the prepared metallographic sections. The vessel was produced by combining the technologies of beating and metal embossing in a pre-cast bronze piece, side ornaments were cast from bronze. Chloride anions were identified along the material grains. It was identified that the mixture of corrosion products covering the surface of the vessel contained, in addition to other elements, basic copper chloride. The presence of chloride anions, atmospheric humidity and mechanical stress lead to corrosion of the bronze vessel called the bronze disease. The material in the upper part of the vessels lost cohesion completely and the neck of the vessel broke as a result of the corrosion process. The vessel was desalinated and reconstructed in a relatively unique way. At present, the vessel is a property of the National Museum in Prague.


The present study has been focused on the preparation of nitrile rubber/ organoclay nanocomposites containing 0–10 wt% Cloisite 93A by mechanical mixing on a two-roll mill. The rubber samples were vulcanized by accelerated sulfur vulcanization process. The role of nanoclay on the curing process has been carefully studied. The clay dispersion in the rubber matrix was analyzed by high resolution transmission electron microscopy (TEM) and X-ray diffraction studies. Both XRD and electron microscopic analyses indicated that the nanocomposites exhibit partly intercalated and exfoliated structure. However, the nanocomposites showed better exfoliation at lower clay loading (2 wt percent) as evident by TEM and XRD. At higher clay loading the clay tend to form aggregates. The correlation distance and the length and thickness of the clay platelets in the rubbery matrix have been deduced from the TEM micrographs as a function of clay loading. The nanoclay-rubber interaction has been quantified by Kraus analysis. The nanocomposites exhibited improved mechanical properties which include tensile strength, modulus, tear strength and resistance to abrasion. The solvent resistance of the nanocomposite increased with the increase in dosage of the nanofiller. Finally, the properties have been modeled using Guth and Halpin-Tsai equations.


This paper deals with the improvement of corporate governance system by emphasizing the enhancement of efficiency through the protection of minority shareholders' rights and management monitoring. Some issues on the current corporate governance system such as management monitoring by the board of directors, the markets and institutional investors are criticized and policy options for the improvement are proposed as follows. First, the ex ante controlling mechanism should be strengthened by securing the independence and quality of outside directors. At the same time, ex post controlling system such as judicial remedy should be established, if shareholders' rights are damaged. For that purpose, it is desirable to introduce class action suits. Second, the conditions of remedial procedures for damages should be eased to some considerable extent as they are still believed to be unrealistic. Third, the function of management monitoring by institutional investors as the dominant outside shareholders should be strengthened because most of firms are dominated by a single family and faced with restrictions of self-control. Fourth, management discipline such as hostile takeover should be activated as it performs a complementary function for internal governance system. Finally, illegal transactions between the firms under the same control should be prohibited definitely as they enable to divert resources inefficiently from one to another.


Objective: To explore the effect of full-course optimized nursing intervention on the clinical prognosis of patients with foreign body impaction (FBI) in the esophagus under gastroscope. Methods: Patients (n=180) with esophageal FBI who underwent gastroscopy were selected and divided into two groups, randomly. The control group (n=85) received traditional nursing intervention, and the research group (n=95) received full-course optimized nursing intervention. The total treatment efficiency, as well as pulse, blood pressure and mental state scores of the two groups before and after nursing were compared. The incidence of postoperative adverse reactions and nursing satisfaction were also compared between the two groups. Results: The total effective rate of treatment in the research group was significantly higher than that in the control group (96.84% vs 88.24%, P<0.05). After nursing, pulse, blood pressure and mental state scores of the two groups of patients were significantly lower than those before nursing, and the improvement of these indicators in the research group was significantly better than the control group (P<0.05). The research group had significantly lower incidence of complications (3.16% vs 15.29%, P<0.01), but higher nursing satisfaction rate (95.79% vs 78.82%, P<0.01) than the control group. Conclusion: Optimized nursing intervention for patients with FBI in the esophagus who received gastroscopy treatment had significantly improved treatment efficiency and reduced incidence of complications, and better nursing experience in both physical and mental aspects, which is worthy of clinical promotion.


This document which is part of a series of seven guidance documents on dementia has been written for all health and social care staff who work with and support people with dementia. This guidance aims to provide healthcare workers with best practice in relation to the assessment and management of hydration and nutrition for a person with dementia throughout their dementia journey


The paper discusses the core traits of Web 2.0 and summarizes the successful business model.Finally,the paper studies the hotspots of demands in the future,points out the long-term developing trend of Web 2.0 and analyzes its influence on the development of electronic commerce in China.


We propose a randomization scheme for splay trees with the same time complexity as deterministic splay trees, but lower constants. We also present experimental results.


Investigations on the floatability of coal were conducted using reagents of various classes of organic compounds. The flotation efficiency was determined at equal extraction of the fuel matter. The results were analyzed on a computer by a staged multiple regression program. The most significant effect on the reagent efficiency seems to be exerted by the total interaction of the dipole moment and the length of the hydrocarbon radical. Examples of compounds include nitrobenzene, benzaldehyde, 1,3-dioxane, alcohols and esters. 3 tables.


The robust fault detection filter design for singular systems with uncertain disturbance is studied.From the viewpoint of L2-gain,the state observer-based robust fault detection filter design for singular systems is formulated as anH∞optimization problem,and is further solved by suitably selecting weighting matrix and observer coefficient matrix,which can maximize the sen-sitivity of fault residual and simultaneously guarantee the robustness of uncertain disturbance residual.The solvable conditions of this optimization problem and the solutions are derived by employing linear matrix inequality techniques.


A capillary tube is widely used as throttling device in small sized refrigeration and airconditioning applications having capacity less than 3 TR. This research paper provides a set of capillary tube performance data in a vapor compression refrigeration system using R-134a as working fluid. Several capillary tubes with different length and inner diameter were selected as test sections. Mass flow rate and Pressure drop through capillary tube was measured for several inlet temperatures of each capillary tube. The sub cooling and superheating temperatures are maintained constant throughout the experimentation. Experimental conditions for the condensing temperatures were selected from 38 to 54o C in the interval of 2o C. The effect of above given parameters on the Pressure difference, Power input, Evaporating capacity and Coefficient of performance for R-134a through the helically coiled capillary tube has been analyzed.


Example embodiments provide a method of generating a routing table entry according to the present invention, comprising: a first BGP speaker receiving a second BGP speaker through the first routing message to the first distribution path and the second delivery path and a second routing message distribution. Determining a first number of next hop BGP speaker of a first next hop list attribute is less than a second number of next hop in the next hop list attribute. Generating a first BGP speaker attribute routing entry according to a first routing path to the destination of the message. Further, embodiments of the present invention further provides a first BGP speaker. Help reduce the workload of the above technical solution preferably configured routing policy.


The C4 bindings of GKS1 and other semantic computer graphics standards like GKS–3D2 and PHIGS3 are long overdue. While GKS was completed in 1985 and GKS–3D2 (and PHIGS3) became an international standard in 1988, none of their C bindings could be standardized, for the simple reason that the C language itself was not a standard. Instead, a host of de facto GKS/C bindings9 appeared.


This paper is about Private Equity Investment in Asian Emerging Markets. A short description of the characteristics of Private Equity and its history is provided. Hence, it reflects the current situation and special requirements of Emerging Markets Private Equity. The implication of all those special conditions leads to a challenging investment environment which requires distinctive investment approach in Emerging Markets Private Equity regarding initial investment placement decision making, monitoring, corporate governance issues as well as viable exit strategies. The paper illustrates value drivers of emerging markets private equity, presents appropriate strategies and their analysis from the investor's point of view.A thesis submitted to the Bucerius/WHU Master of Law and Business Program in partial fulfillment of the requirements for the award of the Master of Law and Business ("MLB") Degree.


In the current time of globalization, collaboration among people in virtual environments is becoming an important precondition of success. This trend is reflected also in the educational domain where students collaborate in various short-term groups created repetitively but changing in each round (e.g. in MOOCs). Students in these kind of dynamic groups quite often encounter various difficulties, which are obvious mainly when students' characteristics do not complement each other. In spite of various group formation methods aimed to solve the group compatibility problem, most of the existing approaches do not consider dynamic groups. We describe (i) a proposal of a novel group formation method based on Group Technology approach, which considers feedback on students' collaboration to improve group formations; (ii) an application of the method as a part of a collaborative platform PopCorm, which provides students in the created groups with a set of real-time collaboration tools; (iii) a long-term experiment in which the groups created by our method achieved significantly better results in comparison with the reference approaches. Our results indicate that considering feedback from students' collaboration can improve the group formation process as the groups created by our method achieved higher collaboration quality with next iterations.


This paper researches on a multi-channel data acquisition system based on USB2.0. In the hardware,the STM32F103RB is used as its microcontroller and chose CY7C68013 manufactured by Cypress corporation USB chip.ADS1271 produced by Ti corporation is used as its A/D chip.On this base,Labview8.20 which is a kind of graphical programming language to complete the application design is chosen.This system's highest sampling rate can reach 80KSPS,it achieves a 18Bit resolution of the 4-channel real-time data collection and can meet the most needs of vast applications.


Recent articles are reviewed to estimate the diagnostic classification and treatment of glomus jugulare tumor.Glomus jugulare tumors are benign lesions located in lateral-skull base,presenting malignant biological behaviors with extending into middle ear,posterior cranial nerves and duramater.The diagnosis and management of glomus jugulare tumor remains controversial.This article sums up the recurrent papers to offer a contemporary diagnostic classification and treatment of glomus jugulare tumor.


Based on investigated data of 2009 in Fujian,this paper systematically analyzes some factors which might influence the floating population's intention of transferring hukou to the destination city.The results show that the intention of transferring hukou to destination city is evidently different,and the effect of the age,education,duration of stay,land,numbers of family members,place of their origin and destination and social integration on the desire is significant.And finally discuss the policy significance of the results.


General-purpose processors alone are sometimes inadequate for digital image processing applications due to the amount of data which must be processed and/or the computational complexity of the algorithms used. An array processor can be used effectively to off-load large image processing tasks from the host processor. Array processors are well-suited to performing typical image processing functions, and extensive off-the-shelf hardware and software are readily available at a reasonable cost. Faster processing elements which run in parallel and/or may be pipelined can yield a typical performance improvement of an order of magnitude compared to a general-purpose processor. Moreover, because an array processor removes most of the image processing function from the host processing environment, overall system throughput is also significantly improved.


Preface Acknowledgements Part I. Fundamentals: 1. Schema roots 2. The nature of a schema 3. The schemas of arithmetic story problems Part II. Schemas and Instruction: 4. Theoretical issues for instruction 5. The story problem solver and the problem solving environment: two examples of schema-based instruction Part III. Learning from Instruction: 6. Learning and schema theory 7. Learning from schema-based instruction 8. The acquisition of planning knowledge 9. The diagram: marker and template Part IV. Schemas and Assessment: 10. Schema-based assessment 11. Assessment in SPS and PSE Part V. Schema Models: 12. Production systems, neural networks and hybrid models 13. The performance model 14. The learning model 15. The full schema model 16. Some concluding remarks on schema theory Notes References Name index Subject index.


3D bioprinting technology has promising applications in regenerative medicine and drug testing in the near future for the fabrication of patient-specific replicas of human organs, bones, etc. Previously, we have developed a dual-arm 3D bioprinting system, TwinPrint, using two robots to cooperatively bioprint peptide-based soft matter structures. During 3D bioprinting, optimization of extrusion flow rates of peptide bioinks is critical for efficient cell encapsulation and mechanical stability. Currently, it is dependent on user knowledge and experience from past experiments which may vary in reliability and quality. Thus, this paper proposes a multi-output regression machine learning model to predict optimized peptide flow rates for the microfluidic-based pumping component of the TwinPrint system. Specifically, parameters including peptide bioink type, peptide concentration, phosphate-buffered saline (PBS) concentration and nozzle size are used as inputs for machine learning methods. The output is estimated optimal flow rates of the bioink fluid components, essential in obtaining a consistent amount of gel extrusion. The dataset used to train and test the predictive model is collected from numerous bioprinting experiments conducted on-site. Performance evaluation metrics are applied to examine and assess the developed model, which is incorporated within our in-house developed TwinPrint software to automatically suggest flow rates once the user specifies initial parameters. Finally, the flow rate predictive software in conjunction with the advanced dual-arm robotic system hardware are demonstrated in this work to pave the way for automated optimization of 3D bioprinting for enhanced printability, repeatability and standardization


Starting from the understanding of the Triangular Approach as a way to elaborate worldsbased on the interpretation of images and artistic objects, an art / educational activitydeveloped during the vacation course of the year 2020 will be presented, at theEscolinha de Arte do Recife (EAR), in order to record how the institution has beenoperating in the contemporary world. First, we will make a historical contextualization ofthe institution's emergence, from its pedagogical perspectives, and then reflect on theartistic activity of stamping with alternative materials, the contributions to the aestheticformation of children. Following artistic methods used by the artist Iza do Amparo, anartist presented during a vacation course module, the children, as will be seen, whencoming into contact with the artist's work and with the artist herself, were able to expandtheir aesthetic perceptions, and capacity for reflection on topics such as: Ethics,Environment and Local Culture.


Interpolation of pre-stack data is a key processing tool for the reduction of acquisition costs and it is generally needed when the wavefield sampling needs to be densified along shot and/or receivers. Irregular and sparse sampling of the wavefield in 3D surveys generates spatial aliasing. Wavefield interpolation by 3D shot continuation operator (3D SCO) can yield densely sampled data by interpolating common shot gathers (e.g., from irregular shot/receiver sampling into a regular acquisition). The tests shown here have been carried out on synthetics (the SEG/EAGE Overthrust Model), and on field data. Synthetic 3D data simulate land and OBC acquisitions; field data is part of a 3D land acquisition. For regularly sampled wavefield (e.g., Overthrust model dataset) the interpolation accuracy of 3D SCO is comparable with other methods (e.g., predictive techniques). When the sampling geometry is not regular such as for 3D land data, the 3D SCO interpolates the needed common shot gathers from the neigbouring ones. The comparison of post-stack data shows that the number of the shot points can be halved since the decimated shot gathers yield an interpolated stack-section with interesting quality.


Background: Previous studies have examined the association between glycated hemoglobin (HbA1c) and hemoglobin (Hb) levels among non-diabetic people. However, there are no reports relating to the correlation between HbA1c values and anemia in women without gestational diabetes. We, therefore, examined whether there is an association between mid-pregnancy HbA1c values and anemia in women without gestational diabetes. Methods: This retrospective cohort study was conducted at the A�liated Hospital of Jining Medical University, Jining, China, from January to December 2019. Cases of single pregnancies in women above 18 years old, with recorded HbA1c values at 14-27 +6 weeks of gestation, were examined. Women with pregestational diabetes mellitus (GDM) or the development of GDM were excluded. The association between variations in mid-pregnancy HbA1c values and anemia was examined. Results: Among 8553 women without gestational diabetes, univariate analysis results demonstrated a signi�cant positive relationship between (P<.001) mid-pregnancy HbA1c values and anemia, after adjusting for confounding factors. Multivariate piecewise linear regression showed that anemia decreased when HbA1c values were <4.6% (OR 0.40; 95% CI, 0.15-1.04; P=.592) and increased when HbA1c values were was >4.6 % (OR 3.83; 95% CI, 2.95-4.98; P<.0001). Conclusion: This study showed a nonlinear relationship between mid-pregnancy HbA1c values and anemia in women without gestational diabetes. When the HbA1c values increased to the in�ection point, they were positively correlated with anemia. Further studies are needed to explore this relationship and the mechanisms involved in the future.


We present Talbot array illuminators based on multilevel phase gratings that exhibit two bright zones for period. Our scheme is based in a matrix description for Fresnel diffraction of substructured gratings that allows us to foresee structural relationships between the diffractive element and its Fresnel wavefield.


Objective To detect the differential expression of HSF1 mRNA,HSP27,HSP70 and HSP90α in mucous membrane,adenoma and carcinoma of colon.Methods By means of tissue microarray technology,detect the expression of heat shock related nucleic acid and proteins with immunohistochemistry and hybridization in situ.Results The positive expression of HSF1 mRNA,HSP27,HSP70 and HSP90α in mucous membrane,adenoma and carcinoma of colon were 21.43%,66.00%,85.71%;35.70%,68.00%,42.90%;28.57%,46.00%,67.35%;21.40%,54.00%,73.50%.The expression level of HSF1 mRNA and HSP90α in adenoma and carcinoma of colon was obviously higher than that in mucous membrane,meanwhile the expression level of HSP27 in adenoma was higher than that in mucous membrane and carcinoma of colon,and the expression level of HSP70 in carcinomar of colon was higher than that in mucous membrane and adenoma.Conclusions The positive expression of HSF1 mRNA,HSP27,HSP70 and HSP90α is interrelated due to the process of colon tumorigenesis,in which the heat shock stress signal pathway that represent played an important role.


This article deals about anthropology, the human nature, in relationship with the Cosmic Conflict as is presented by Ellen White. The purpose is to have a better understanding how this conflict, which began in heaven with Satan and established on Earth according to Genesis 3, influence our nature today. In relationship with the Great Conflict between Christ and Satan, it is very important focus not only in the consequences of sin for us today, but to see the solution for this Conflict, as the Bible and Ellen White teach, which will end with the glorious coming of Jesus soon, following what Ellen White wrote about this issue.


The results of treatment of 188 consecutive new patients with a primary diagnosis of fissure‐in‐ano presenting to the Outpatient Department of St Mark's Hospital are reviewed. One‐third underwent operation as the primary treatment and were not studied further. Of the remaining patients who underwent non‐operative treatment only, one‐half were initially cured. Follow‐up at 4 years showed that this cure was maintained in half of these‐cases, suggesting that there is aplace for treatment with a dilator in the correctly selected case.


When designing a complex product in a collaborative engineering context, interface management is a major concern. An interface control document is the main means to avoid assembly errors, misinterpretations and problems in work package coordination. Therefore, in a collaborative engineering environment, the question that arises is: How can we facilitate the management of interfaces and improve the control of documents in a PLM context? This paper proposes a numerical representation of geometrical and functional constraints related to interface control documents. A template typology as well as the corresponding implementation methods for these templates in a CAD environment is suggested as the means to verify the constraints between two subsystems. This numerical format provides engineers with the necessary tools to manage interfaces. Interface control documents become clearer and easier to share with partners. Moreover, these new methods are compatible with designer's work habits. Keyword: Interface management; interface control document; computer aided; complex product.