Rich, colorful, painstakingly detailed, Dying in a Strange Land tells the Oyama family saga, as routed and rooted across the Pacific from Japan to Hawai'i and the continental USA in California and New York. It is also a novel of modern Hawai'i's history showing the rise of the Japanese immigrants from hard-knock plantations into social power via labor unions, the ILWA, the Democratic party-machine and ethnic-labor coalitions against the quasi-colonialism and white hegemony of past regimes. But, at the core, this is a novel of artistic self-formation showing how long-time San Francisco resident Milton Murayama made himself into a postwar novelist capable of remembering and shaping all this diasporic Japanese/Hawaiian family material into historical fiction and 'local literature' at its polylingual and postcolonial best. Postcolonial readers in Asia-Pacific areas may already know and love Murayama's Oyama family saga*the family's emigration from farming regions in Japan, its struggles with poverty and freedom on the prewar plantations of Maui, class and ethnic tensions in the racial hierarchies of Hawai'i, the traumas and divisions of the World War II years, the rise to middle-class success of the local Japanese in the postwar democratization of Hawai'i, its diaspora to the mainland US, the generational struggles to endure and survive as a unity of clashing figures. All of this has been touched upon in Murayama's plantation-saga trilogy of All I Asking for Is My Body (1975), Five Years on a Rock (1994) and Plantation Boy (1998). Extending the voices and values of the seven siblings and eccentric parents of this scrappy and memorable family, Dying in a Strange Land adds to this Oyama family struggle a novel of artistic self-formation, showing how Milton Murayama* alias Morris Kiyo Oyama*was able to become, against all social odds in the postwar period of Civil Rights struggles and wars in Asia, a writer of ethnic integrity, postcolonial polyphony, historical sway, racial tensions, and global/local vision. This fourth novel is a narrative remapping of the


With the aim of implementing an instrumental network for monitoring the micro-seismicity of the whole territory of the Dominican Republic, a remote sensing study was performed. This study was based on georeferenced black/white images LANDSAT TM (Thematic Mapper) at a scale 1:250.000. The aim of the study was the recognition and analysis of lineaments of the entire territory of Domi- nican Republic. The term "lineament" corresponds to all linear elements, generally rectilinear or slightly curvi- linear, that intersect topographic surface and are connected with geological phenomena that concern bedrock. All lineaments recognized (17.300 for a total lenght of 26.000 km) were plotted on a map at a 1:500.000 scale. Furthermore, a statistic analysis of the lineament radial distribution and of their persistence was done. Linea- ments recognized can be compared with bibliographic data and are compatible with cinematic models presently applied to explain the recent history of Dominican Republic.


Introduction * The Causes of War * The Military World * War and People * Europe * Middle East and North Africa * Asia * Africa * Latin America * Peacebuilding * Table of Wars * References * Index


Finding and understanding correlated performance behaviour of the individual functions of massively parallel high-performance computing (HPC) applications is a time-consuming task. In this poster, we propose filtered correlation analysis for automatically locating interdependencies in call-path performance profiles. Transforming the data into the frequency domain splits a performance phenomenon into sub-phenomena to be correlated separately. We provide the mathematical framework and an overview over the visualization, and we demonstrate the effectiveness of our technique.


Objective To construct a fusion expression system of capsular gene of Cryptococcus neoformans and green fluorescent protein (GFP) gene.Methods The capsular gene CAP60 was obtained by PCR method and sequenced for verification,then the capsular gene and other essential genes was linked into shuttle vector by ligase.Results We got a 6150bps plasmid,including CAP60 gene, promotor, terminator and fluorescent protein gene.Conclusion The fusion expression of capsular gene of Cryptococcus neoformans and GFP gene will help to research the biochemical synthesis pathway of the capsular polysaccharide.


This supplementary material provides additional details and results of our approach. We first discuss privacy and ethical concerns in Sec. 1. Then, we present details about the BR-5K dataset and our networks in Sec. 2. Lastly, Sec. 3 presents the settings of compared methods and more exper-imental results.


This paper analyzes the reason why the effect of cohesive plain backfill foundation reinforced by dynamic compaction is not ideal.


• Statistics: A 2 x 4 mixed between-within subjects ANOVA (p<0.05) was conducted to explore the effects of speaker group and distraction. Post hoc pairwise comparisons were conducted using Holm-Sidak pairwise multiple comparisons with p values adjusted for multiple comparisons. Secondly, examination of individual TBI participant data was conducted using a series of three one-way repeated measures ANOVA with an alpha level of 0.05. Post hoc analysis was conducted using pairwise multiple comparison procedures (Tukey test) with adjusted alpha.


This study aims to analyze the rhetoric of the thoughts and ideas of Susilo Bambang Yudhoyono (SBY) as the sixth President of the Republic of Indonesia. Through his speech (July 24 '18), on YouTube, and later written on CNN online media, related to the process of forming a political party coalition that brought Prabowo Subianto as a presidential candidate in the 2019 election. The theory used in this study was qualitative-descriptive with an analytical approach critical discourse from Teun A. Van Dijk seen in dimensions; (1) text structure, (2) social cognition, and (3) social context, then associated with mass communication theory from HarollD Laswell. The results of this study are summarized with the mass communication model in form, function and meaning. The results obtained from this study create a model of mass communication with text structure (form), social cognition (function) and social context (meaning).


X-Ray crystallographic study shows that 3-methyladenine, the product of methylation of DNA by carcinogenic and/or mutagenic methylating agents, stacks strongly with the indole ring, the aromatic side group of tryptophan.


The SCC‐DFTB/MIO/CHARMM free energy surface for a glycosyltransferase, TcTS, is benchmarked against a DFT/MM reaction trajectory using the same CHARMM MM force field ported to the NWChem package. The popular B3LYP functional, against which the MIO parameter set was parameterized is used to optimize TS structures and run DFT reaction dynamics. A novel approach was used to generate reaction forces from a SCC‐DFTB/MIO/CHARMM reaction surface to drive B3LYP/6‐31G/MM and B3LYP/6‐31G(d)/MM reaction trajectories. Although TS structures compare favorably, differences stemming primarily from a minimal basis set approximation prevented a successful 6‐31G(d) FEARCF reaction dynamics trajectory. None the less, the dynamic evolution of the B3LYP/6‐31G/MM‐computed electron density provided an opportunity to perform NBO analysis along the reaction trajectory. Here, we illustrate that a successful ab initio reaction trajectory is computationally accessible when the underlying potential energy function of the semi‐empirical method used to produce driving forces is sufficiently close to the ab initio potential. © 2017 Wiley Periodicals, Inc.


Abstract An efficient procedure for the regioselective tritylation of primary hydroxyl group of aldohexopyranosides and nucleosides using trityl chloride in the presence of 1,4-diazabicyclo[2.2.2]octane (DABCO) in dichloromethane has been developed. Subsequent acetylation of the tritylated products in the same pot has been made possible, thereby providing an efficient route to the fully protected carbohydrate derivatives that can be discriminated chemoselectively.


The tissue polarity pathway is required for the establishment of epithelial polarity in a variety of vertebrate and invertebrate organs. Core tissue polarity proteins act in a dynamically regulated complex to direct the polarization of the Drosophila eye. We report the identification and characterization of bedraggled (bdg), a novel gene that regulates one output of the tissue polarity pathway—the establishment of the R3/R4 photoreceptor fates. bdg encodes a novel, putative transporter protein and interacts genetically with all of the core polarity genes to influence the specification of the R3 and R4 cell fates. Finally, bdg is required for both viability and the initial stages of imaginal disc development.


The commercial operation of unmanned aerial vehicles (UAVs) would benefit from an onboard capability to sense and avoid (SAA) potential mid-air collision threats in the same manner expected from a human pilot. In this paper we present a new approach for detection of aircraft below the horizon. We address some of the challenges faced by existing vision-based SAA methods such as detecting stationary aircraft (that have no relative motion to the background), rejecting moving ground vehicles, and simultaneous detection of multiple aircraft. We propose a multi-stage vision-based aircraft detection system which utilises deep learning to produce candidate aircraft that we track over time. We evaluate the performance of our proposed system on real flight data where we demonstrate detection ranges comparable to the state of the art with the additional capability of detecting stationary aircraft, rejecting moving ground vehicles, and tracking multiple aircraft.


As is well known many engineering structures and components containcracks or crack-like flaws. It is widely recognised that crack growth must be consideredboth in design and in the analysis of failures. The complete solution of a crack growthproblem includes determination of the crack path. Macroscopic aspects of crack pathshave been of industrial interest for a very long time. At the present state of the art thefactors controlling the path taken by a crack are not completely understood. Thepurpose of this introductory paper is to set the scene for the more detailed papers whichfollow. Eight brief case studies are presented. These are taken from the author'sprofessional and personal experience of macroscopic crack paths over the past 50years. They have been chosen to illustrate some of the more important aspects of crackpaths. Many more examples are included in the invited and contributed paperspresented during the Conference.INTRODUCTION


ABSTRACT Rationale/Purpose The purpose of this study is to utilize Social Comparison Theory and the Big Fish Small Pond Effect to examine the experiences of student-athletes and coaches from academically elite NCAA Division III institutions and their perceptions of what it means to them to be a student-athlete at an academically elite Division III institution. Design/methodology/approach The authors examined the intersectional patterns of NCAA level, academic prestige, and aggregate athletics department success and then conducted semi-structured interviews with 19 student-athletes and 12 coaches across two academically elite Division III institutions. Findings Four themes emerged: (1) understanding the recruiting competition and other schools academically elite Division III student-athletes consider, (2) the unique pairing of athletics rigor and academic rigor, (3) the role of having athletics at academically elite Division III institutions, and (4) "Why this?" – framing the academically elite Division III experience. Practical Implications Findings have implications for coaches, athletics administrators, and campus administrators as they situate the role of athletics offerings on campus and gain a better understanding of student-athlete experiences and priorities. Research contribution Discussion focuses on the relevance of this environment in relation to frame-of-reference ideas, self-concept, Social Comparison Theory, and the Big Fish Small Pond Effect.


Neutron spectrum information will be obtained throughout the FFTF during acceptance testing by irradiating passive dosimeters in special characterizer assemblies in fuel, reflector, in-vessel storage, and reactor cavity locations. An irradiation was performed in the In-Reactor Thimble (IRT) in a geometry similar to that of the proton recoil neutron spectrum measurements to assess the adequacy of spectra and uncertainties obtained using the passive dosimeter technique. In addition, reaction rates involving short-half-life products important to reactor operation and maintenance were measured.


A revised fire outbreak and evacuation simulation model, MFIRE, is presented in the paper. The model provides information for setting up an emergency ventilation scheme, establishing safety procedures and minimizing damage in underground network systems. MFIRE simulates the interdependence between the ventilation system and its pertinent fans and structures, and the changes in ambient conditions and the heat source. A laboratory based fire simulation was conducted in a small physical tunnel network to verify the MFIRE. The rates of air flow and temperature distribution in each tunnel are compared with the simulated results obtained by MFIRE. Regarding air flow, the experimental rates correlate with the simulated results very well. Because of the reduced physical scale of the laboratory model, the simulated temperature distributions do not quite correlate with the laboratory data. MFIRE is employed to simulate a hypothetical fire outbreak in the Taipei Mass Rapid Transit System. The simulation is designed to investigate the direction and rate of air flow, temperature distribution and emergency ventilation responses. The results have confirmed that the proposed ''push– pull'' ventilation model can exhaust the high temperature air and smoke out of the underground facilities efficiently once the fire breaks out. # 2001 Elsevier Science Ltd. All rights reserved.


For hard goods manufacturers with complex and varied product development processes, PLM technology has the potential to provide strong business value. These leading practices will answer your most common questions and help accelerate time to value with PL


From multiple-spacecraft measurements it is shown that the synchronous orbit manifestation of a substorm, i.e., plasma injection and magnetic field reconfiguration to dipolar, has an onset which expands both eastward and westward from a relatively narrow sector near midnight. For low-to-moderate geomagnetic activity the earliest onset sector at synchronous orbit is about 3 hours wide, skewed toward the evening side of midnight. Using the extensive International Magnetospheric Study ground magnetometer network beneath the satellites, it is found that simultaneous westward motion of electrojet intensification is seen in the ground data over a larger longitudinal range than the magnetospheric signatures. This might be explained in terms of distortion of the nightside magnetic field at synchronous orbit. Plasma that has already been injected near midnight at synchronous altitude undergoes no further change as a result of the westward and eastward motion of the borders of the plasma. This suggests that the expansion does not represent new substorm activation. One can interpret these results in terms of an injection front wedge which makes hot plasma accessible to the inner magnetosphere and which spatially expands or propagates with time. The origin of plasma behind the front is not addressed. Detailed pitch angle data do, however, show that strong precipitation would be expected from the front for about the first 10 min after the front passes over an observer. Finally, as a result of longitudinal expansion of plasma injections from midnight toward evening or morning and the continuation or even enhancement of field inflation in the evening or morning sectors, growth and expansive phase substorm signatures can occur simultaneously. Substorm expansion at midnight can thus be accompanied by continued growth signatures in evening or morning.


Auditory psychophysical performance has been measured using electrical stimulation of the remaining VIII nerve and of the cochlear nucleus in deaf patients. Psychophysical measures of temporal envelope processing show relatively unimpaired performance in these patients compared to normal hearing, and speech discrimination scores indicate that speech information relating to temporal envelopes can be effectively transmitted and received. This finding also indicates that the cochlea and VIII nerve may play relatively little role in the following tasks: detection of gaps, detection of modulation, recovery from adaptation, nonspectral pitch discrimination, and duration discrimination. Intensity perception is impaired with electrical stimulation: dynamic range of usable loudness is only 10 to 20 dB and intensity discrimination experiments indicate only 10 to 40 discriminable intensity levels. Frequency resolution is completely absent in electrical stimulation and can be only crudely reconstructed by multiple el...


ABSTRACT The U.S. Coast Guard (USCG) enforces regulations for vessel response plans and marine transportation-related facility response plans for oil. The U.S. Environmental Protection Agency (EPA) enforces similar regulations for response plans for non-transportation-related facilities. Proposed USCG rules would require response plans for hazardous substances designated under the authority of the Clean Water Act (CWA). Other USCG regulations implement provisions of the International Convention for the Prevention of Pollution from Ships, known as MARPOL 73/78. Annex I of MARPOL 73/78 addresses petroleum pollution, while Annex II identifies and addresses Noxious Liquid Substances (NLSs). The Coast Guard and Maritime Transportation Act of 2004 gives the USCG authority to require response plans for NLSs under the CWA. There is some overlap, however, in the substances that are listed as NLSs and those that are categorized as oils or designated as CWA hazardous substances. Adding NLSs to the list of substances...


In this context we investigated, for the first time, the organi-zation of a non-amphiphilic tricationic switchable rotaxaneand its dumbbell-shaped component into Langmuir films andLangmuir–Blodgett (LB) multilayers by using a cospreadingstrategy. The Langmuir films have been characterized by sur-face pressure–area (


With the apparent focus of work carried out by the heritage 'community' very much directed towards heritage practices in the present, the potential historical scope for the discipline as a whole, becomes ever-more temporally closed. This paper makes space for a longer historical analysis of the development of heritage as a process. The paper ranges over the evolution of a medieval sense of heritage and how it is related to transitions in the experience of space and place, and also explores some early modern developments in the heritage concept, relating them to societal changes associated with colonial (and post-colonial) experience. This deeper understanding of the historically contingent and embedded nature of heritage allows us to go beyond treating heritage simply as a set of problems to be solved, and enables us to engage with debates about the production of identity, power and authority throughout society.


A novel flow injection analysis method for the determination of doxium was established.It was based on that doxium could inhibit the chemiluminescence of eerium sulfate and sodium culfite system.The effect of experiment conditions was also discussed.In the acidic medium,the linear range was 4.0×10~(-6)~6.0×10~(-5) mol/L with a correlation coefficient of 0.9976,the determination limit was 2.0×10~(-6) mol/L,the relative standard deviation was 1.2%(n=6).


The atlas of human acupoints and meridians has been utilized in clinical practice for almost a millennium although the anatomical structures and functions remain to be clarified. It has recently been reported that a long-distance interstitial fluid (ISF) circulatory pathway may originate from the acupoints in the extremities. As observed in living human subjects, cadavers and animals using magnetic resonance imaging and fluorescent tracers, the ISF flow pathways include at least 4 types of anatomical structures: the cutaneous-, perivenous-, periarterial-, and neural-pathways. Unlike the blood or lymphatic vessels, these ISF flow pathways are composed of highly ordered and topologically connected interstitial fibrous connective tissues that may work as guiderails for the ISF to flow actively over long distance under certain driving forces. Our experimental results demonstrated that most acupoints in the extremity endings connect with one or more ISF flow pathways and comprise a complex network of acupoint-ISF-pathways. We also found that this acupoint-ISF-pathway network can connect to visceral organs or tissues such as the pericardium and epicardium, even though the topographical geometry in human extremities does not totally match the meridian lines on the atlas that is currently used in traditional Chinese medicine. Based on our experimental data, the following working hypotheses are proposed: 1, there are one or more ISF flow pathways, including at least one cutaneous pathway, originated from an acupoint on the body surface. 2, the acupoints on the body surface specifically connect with certain visceral organs or tissues via ISF flow. And 3, the acupointoriginated ISF pathways constitute a complex connective network and can modulate the ISF and bio-signals in the microenvironments around cells in certain visceral organs or tissues from body surfaces. A comprehensive atlas will be constructed to systemically reveal the detailed anatomical structures of the acupoints-originated ISF circulation. Such an atlas may shed light on the mysteries shrouding the visceral correlations of acupoints and meridians, and inaugurate a new frontier for innovative medical applications.


The article considers the role of innovation potential of a region in ensuring stable social reproduction of economic potential. It identifies components of innovation potential, which characterise resources and ability to realise them, that identifies capabilities of territorial enterprises to develop in innovation manner. It underlines importance of development and adaptation of the methods of calculation of the overall development of innovativeness for Ukrainian regions with the purpose to assess the state of innovation activity in the country compared to neighbouring countries - EU members. The article offers an approach, which allows development of conceptual directions of innovation strategy of economic growth. It emphasises priority of establishment and support of the regional innovation system as a necessary factor of development of innovation infrastructure and gives proposals regarding the issue of creation of innovation structures in the region.


Introduction In younger patients with AML achieving CR1 with intermediate or high risk disease allogeneic HSCT is the treatment of choice. Conditioning intensity is varied, reduced intensity (RIC) conditioning regimens are usually given to older patients, whereas young patients traditionally receive myeloablative regimens (MAC). In patients between the ages of 40-60 both types of regimens are used with little knowledge about factors that would lead physicians to prefer one over the other. Previous studies had shown that RIC regimens were associated with somewhat higher relapse risks but lower risks of transplant related mortality (TRM). We hypothesized that in low-intermediate risk disease based on cytogenetic classification RIC is superior to MAC whereas in high risk leukemia MAC is superior to RIC given higher antileukemic activity.

Patients and Methods This study included 2974 of 5388 eligible patients with AML transplanted in CR1 in 2000-2011 based on the availability of cytogenetics to classify by risk status at diagnosis. Only sibling or unrelated donors and marrow or peripheral blood stem cell transplants were considered. Regimens were classified as MAC (n=1638) or RIC (n=1336) based on published criteria. Median follow-up of surviving patients was 46 and 41 months respectively. Groups differed by many variables. MAC recipients were significantly younger (37.6 vs 53.8 years), had a shorter interval from diagnosis to transplantation (143 vs 165 days), were more frequently male (53% vs 48%), had less frequently poor risk cytogenetics 19% vs 22%, received less frequently stem cells from an unrelated donor (20% vs 33%), and had more frequently marrow as a stem cell source (36% vs 7%). The Kaplan-Meier estimator, the cumulative incidence function and Cox proportional hazards regression models were used where appropriate.

Results [Table 1][1] shows similar overall (OS) and leukemia free survival (LFS) in both groups but a lower relapse incidence (RI) and a higher transplant related mortality incidence (TRM) in the MAC group. Acute grade II-IV GvHD was higher with MAC, incidence of chronic GvHD did not differ significantly.

View this table:

Table 1

In univariate analysis overall survival was higher with RIC in cytogenetic good risk AML (55±5% vs 77±7% MAC vs RIC) but not in intermediate risk (61±1% vs 62±2%) or poor risk AML (42±3% vs 40±3%). Relapse incidence was lower with MAC in poor risk AML (36±3% vs 51±3%) and intermediate risk AML (21±1% vs 30±1%) but not in good risk AML (19±4% vs 13±5%). TRM was higher in MAC vs RIC in all three cytogenetic risk groups. Multivariate analysis confirmed a significant LFS and OS advantage of RIC in good risk but not in intermediate and poor risk leukemia.

Conclusions In patients aged 40-60 MAC conditioning has no advantage over RIC conditioning in spite of RIC transplant recipients being generally in a poorer risk category. We confirm lower relapse rates but higher TRM risks with MAC compared to RIC. We fail to show superiority of MAC in patients with high risk cytogenetics but there appears to be an advantage for RIC over MAC in the small cohort of patients with good risk leukemia.

Disclosures: Kuball: Miltenyi: GMP product development Other.

 [1]: #T1


. PURPOSE: Masculinizing chest reconstruction (MCR) has been shown to improve quality of life and gender dysphoria in transmasculine adult patients. As nationwide access to gender-affirming care expands, more adolescents are seeking MCR. However, there is a paucity of literature examin-ing patient characteristics, safety, and disparities in access among this population. National guidelines are unclear and insurance coverage is limited for patients under 18, which can lead to artificial delay in surgery. The goal of this study is to assess the safety of adolescent MCR when compared to young adults and to examine disparities in outcomes and access to these procedures.


The aim of this study was determination of biologically active substances in coffee. Biological activity was determined in 23 samples of coffee spectrophotometrically using two methods. The first one is DPPH method, the second one Folin-Ciocalteu method. In order to achieve the greatest diversity were used roasted coffee beans and ground coffee. And because today´s fair offers a lot of varinats, it was tested different kinds of blends, including decaffeinated coffee.


Research of the distribution earthquakes risk probability based on earthwuakes data were conducted within Lampung area, situated at between koordinate 101 o and 108 o longitude, 2 o and 7 o latitude.  The earthquakes data were collected in period 1900-2004. Gridding of the research area within interval 0,5 o due to calculate and distribute of the maximum ground motion acceleration. The calculation is using Fukushima and Tanaka Equation. There are eight classifications correlated with risk: (1) Height (top), the intensity is VIII MMI, the maxsimum ground acceleration 2300 s.d. 2900 µm s -2 , (2) Height (midle), the intensity is VII MMI, the maxsimum ground acceleration 1800 s.d. 2300 µm s -2 , (3) Height (bottom), the intensity is VI MMI, percepatan maksimum getaran tanah 1000 s.d. 1800 µm s -2 , (4) Moderate, the intensity is V MMI, the maxsimum ground acceleration 1000 s.d. 1400 µm s -2 ,  (5) Moderate, the intensity is V MMI, the maxsimum ground acceleration 680 s.d. 1000 µm s -2 , (6) Low, the intensity is III MMI, the maxsimum ground acceleration 400 s.d. 680 µm s -2 , (7) Low, the intensity is II MMI, the maxsimum ground acceleration 180 s.d. 400 µm s -2 , (8) Low, the intensity is I MMI, the maxsimum ground acceleration < 180 µm s -2 . The degree of the risks are clasified that the surounding of the Liwa town has the positif risk and the area outsides of surounding of the Liwa Town are not harm Keywords: earthquake, risk, ground motion acceleration


ZnO film is attracting more attention because of its ultraviolet emission at room temperature and its poten-
tial applications in ultraviolet photoelectron devices in recent years. For the applications preparation of good-quality
ZnO films and strong ultraviolet emission in films are requested. Annealing in different ambiences is a good method
to improve the quality and to change the stoichiometrical composition.
 ZnO films were prepared by direct current reaction sputtering and annealed in different oxygen partial pressures
(P_(O_2)). The laser lasing on the films was observed from the time resolution spectrum. X-ray diffraction analysis
shows that the crystal constants decrease and the gain sizes of films increase with P_(O_2), these analysis and images of
films by atom force microscopy show that the qualities of ZnO films were improved by annealing in oxygen ambi-
ences. The influences of annealing P_(O_2) on photoluminescence (PL) and its relation to native defects were investi-
gated also. We found that the intensities of ultraviolet photoluminescence were increased with oxygen partial pres-
sures in certain range of P_(O_2) due to the improvement of the structure of films. But in higher P_(O_2), ultraviolet intensi-
ties decreased and green intensities increased instead. We suggest that more excitation energy was transferred to
 green center because of the generation of more acceptors in higher P_(O_2) that these acceptors act as green emission
center in the films, the refore UV was decreased, green was increased. The compositions analyses in depth of sam-
ples A and E by Auger electron spectra show that A film (annealed in pure N_2 ambience) has stoichiometry of
[Zn]/[O]1 and Samples E (in pure O_2) has that of [Zn]/[O]1, it indicates there are more donor defects in
Sample A and more acceptors in Sample E. The I-V curves of the junctions Sample E indicates the more acceptors
generated in the ZnO film and may inversed to p-type semiconductor due to annealing in higher P_(O_2).


The aim of this thesis is to scrutinize and develop four state-of-the-art power electronics converter control techniques utilized in various photovoltaic (PV) power conversion schemes accounting for maximum power extraction and efficiency. First, Cascade Proportional and Integral (PI) Controller-Based Robust Model Reference Adaptive Control (MRAC) of a DC-DC boost converter has been designed and investigated. Non-minimum phase behaviour of the boost converter due to right half plane zero constitutes a challenge and its non-linear dynamics complicate the control process while operating in continuous conduction mode (CCM). The proposed control scheme efficiently resolved complications and challenges by using features of cascade PI control loop in combination with properties of MRAC. The accuracy of the proposed control system's ability to track the desired signals and regulate the plant process variables in the most beneficial and optimised way without delay and overshoot is verified. The experimental results and analysis reveal that the proposed control strategy enhanced the tracking speed two times with considerably improved disturbance rejection. Second, (P)roportional Gain (R)esonant and Gain Scheduled (P)roportional (PR-P) Controller has been designed and investigated. The aim of this controller is to create a variable perturbation size real-time adaptive perturb and observe (P&O) maximum power point tracking (MPPT) algorithm. The proposed control scheme resolved the drawbacks of conventional P&O MPPT method associated with the use of constant perturbation size that leads to a poor transient response and high continuous steady-state oscillations. The prime objective of using the PR-P controller is to utilize inherited properties of the signal produced by the controller's resonant path and integrate it to update best estimated perturbation that represents the working principle of extremum seeking control (ESC) to use in a P&O algorithm that characterizes the overall system learning-based real time adaptive (RTA). Additionally, utilization of internal dynamics of the PR-P controller overcome the challenges namely, complexity, computational burden, implantation cost and slow tracking performance in association with commonly used soft computing intelligent systems and adaptive control strategies. The experimental results and analysis reveal that the proposed control strategy enhanced the tracking speed five times with reduced steady-state oscillations around maximum power point (MPP) and more than 99% energy extracting efficiency.Third, the interleaved buck converter based photovoltaic (PV) emulator current control has been investigated. A proportional-resonant-proportional (PR-P) controller is designed to resolve the drawbacks of conventional PI controllers in terms of phase management which means balancing currents evenly between active phases to avoid thermally stressing and provide optimal ripple cancellation in the presence of parameter uncertainties. The proposed controller shows superior performance in terms of 10 times faster-converging transient response, zero steady-state error with significant reduction in current ripple. Equal load sharing that constitutes the primary concern in multi-phase converters has been achieved with the proposed controller. Implementing of robust control theory involving comprehensive time and frequency domain analysis reveals 13% improvement in the robust stability margin and 12-degree bigger phase toleration with the PR-P controller. Fourth, a symmetrical pole placement Method-based Unity Proportional Gain Resonant and Gain Scheduled Proportional (PR-P) Controller has been designed and investigated. The proposed PR-P controller resolved the issues associated with the use of the PI controller which are tracking repeating control input signal with zero steady-state and mitigating the 3rd order harmonic component injected into the grid for single-phase PV systems. Additionally, the PR-P controller has overcome the drawbacks of frequency detuning in the grid and increase in the magnitude of odd number harmonics in the system that constitute the common concerns in the implementation of conventional PR controller. Moreover, the unprecedented design process based on changing notch filter dynamics with symmetrical pole placement around resonant frequency overcomes the limitations that are essentially complexity and dependency on the precisely modelled system. The verification and validation process of the proposed control schemes has been conducted using MATLAB/Simulink and implementing MATLAB/Simulink/State flow on dSPACE Real-time-interface (RTI) 1007 processor, DS2004 High-Speed A/D and CP4002 Timing and Digital I/O boards.


Collecting effective healthcare survey data requires a novel approach differed from traditional paper-based methods where manual electronic data entry would be required. Inaccuracy and mistakes can occur at any points from gathering, transporting to entering collected data into a computer. dCollective is a cloudbased software application designed to assist healthcare workers to design customized online survey forms for interviewers, patients and caretakers. The workers create, manage and assign electronic forms to their target groups. Survey forms can be logically stored and retrieved based on various variables such as patient's age, gender, medical state and clinical status. In addition to typical data gathering from paper forms, a dCollective form may include geolocation along with picture, audio and video. Data from each form is extracted to construct longitudinal information pertaining to each patient. This information will be used alongside respected patient's medical record to create visual representations and statistical reports for each patient or a group of patients based on a set of search criteria.


ABSTRACT In the complex sphere of global television dramas, South Korea has emerged as a regional force in the last few decades, followed by Turkey in the 2000s. Turkish TV dramas are sold to over 140 countries throughout the world, demanding a constant supply of new content, met in part by remakes. While Korean productions receive limited distribution in Turkey, a significant number of these have been remade by Turkish companies. Since 2013, Korean dramas have replaced Hollywood series as the primary source of adaptations for Turkish dramas. There appear to be shared sensibilities that make the Korean stories palatable to Turkish audiences, but more significantly, certain production practices make Korean sources a more viable choice than Hollywood series for Turkish producers. This article explores these sensibilities from an industrial point of view, employing testimonies from leading industry informants who have been instrumental in introducing Korean source material to Turkish television.


The gluon recombination functions in the twist-4 QCD evolution equations are studied at the leading logarithmic approximation using both the covariant and non-covariant methods. We justify that the infrared singularities in the twist-4 coefficient functions impede us to simply separate the QCD evolution kernels from the coefficient functions at the equivalent particle approximation. In particulary, we point out that the gluon recombination functions in the GLR-MQ evolution equation are unavailable. The methods avoiding the IR divergences are discussed, which can be used in the derivations of the evolution kernels and coefficient functions at the higher twist level.


Another critical element is the system of sealing the silicon to prevent the ingress of moisture and oxygen. It is this which represents the greatest threat to secure storage, according to the professor, and which will eventually make all data stored on DCs or DVDs unreadable, with several studies measuring the life span of present-day discs as between 10 and 15 years. Hard drives are also said to be a poor option because of problems with magnetic fields.


In each volume of Progress in Community Health Partnerships: Research, Education, and Action, the editors select one article for our Beyond the Manuscript, podcast interview with the authors. Beyond the Manuscript provides authors with the opportunity to tell listeners what they would want to know about the project beyond what went into the final manuscript. Beyond the Manuscript podcasts are available for download on the journal's website (http://www.pressdev.jhu.edu/journals/ progress_in_community_health_partnerships/multimedia.html). This Beyond the Manuscript podcast is with Jamie Zoellner, Assistant Professor of Nutrition and Food Systems at the University of Southern Mississippi, lead author of Fit for Life Steps, Results of a Community Walking Intervention in the Rural Mississippi Delta, and Demetric Warren, staff member of the Hollandale Lower Mississippi Delta Nutrition Intervention Research Initiation, who contributed to the study project. Lee Bone, Associate Editor, and Associate Professor at the Johns Hopkins University Bloomberg School of Public Health, conducted the interview. The following is an edited transcript of the Beyond the Manuscript podcast.


Many engineering and scientific applications necessitate the estimation of statistics of various functionals on stochastic processes. In Chapter 2, Norros et al's Girsanov theorem for fBm is reviewed and extended to allow for non-unit volatility. We then prove that using method of images to solve the Fokker-Plank/Kolmogorov equation with a Dirac delta initial condition and a Dirichlet boundary condition to evaluate the first passage density, does not work in the case of fBm.

Chapter 3 provides generalisation of both the theorem of Ramer which finds a formula for the Radon-Nikodym derivative of a transformed Gaussian measure and of the Girsanov theorem. A P-measurable derivative of a P-measurable function is defined and then shown to coincide with the stochastic derivative, under certain assumptions, which in turn coincides with the Malliavin derivative when both are defined. In Chapter 4 consistent quasi-invariant stochastic flows are defined. When such a flow transforms a certain functional consistently a simple formula exists for the density of that functional. This is then used to derive the last exit distribution of Brownian motion.

In Chapter 5 a link between the probability density function of an approximation of the supremum of fBm with drift and the Generalised Gamma distribution is established. Finally the self-similarity induced on the distributions of the sup and the first passage functionals on fBm with linear drift are shown to imply the existence of transport equations on the family of these densities as the drift varies.


Objective: To assess the effect of continuous intrathecal baclofen infusion (ITB) on gait parameters of ambulant children with cerebral palsy (CP). Methods: The assessment before and 16 months after ITB on seven children with CP (mean age 15 years, SD 5.4) included: Ashworth scale score, range of motion (hip, knee, ankle), Gillette functional assessment questionnaire (FAQ), joint kinematics, spatiotemporal parameters and Gillette Gait Index (GGI). Results: Gillette FAQ significantly improved from 6.1 to 7.1. Mean GGI improved from 554.50 to 489.25, which was not significant although the improvement was large for three children. Parameters in the sagittal plane were significantly modified with a significant increase in step length (0.65 m to 0.74 m) and a significant increase in hip extension during stance phase (32.25° to 21.6°). These results were correlated to clinical assessments. Conclusion: ITB seems to improve sagittal gait parameters of children and young adults with CP.


Abstract
This research explores tau-tau statue as identity by looking at function, meaning, and rituals. Tau-tau is the statue that represents a Torajan noble family who has passed away. The findings of this study reveal that tau-tau is one of the main equipment in the funeral (rambu solo') only for high nobility (tana' bulaan). The ritual use of this tau-tau is that after the funeral ceremony is completed, only tau-tau nangka (statue from jackfruit) stored on the cliffs in line with preceded tau-tau, while the tau-tau lampa (statue from mixed of wood) and batelepong (statue for everyone) thrown away after the funeral ceremony is completed. This is because the raw materials of tau-tau lampa and batelepong only made of packing cloth on a bamboo frame that is only temporarily as part of a series and at the funeral ceremony took place. In the beginning, tau-tau was prayed and lamented by families and communities of Torajan Aluk to Dolo, but in line with people left Aluk to Dolo by the Torajan community and switch to embrace Christianity and Islam. Because of this, ritual of tau-tau Aluk to Dolo in rambu solo (funeral ceremony) is not related to rituals and ancestors'beliefs. As a consequence, one of the nobility identities, "tau-tau" even now made by the noble family before they die, and souvenir of tau-tau emerges for sale to the tourists. Thus, the statue of tau-tau at this time is still one of the prides of Torajan noble, but all the sacred rituals of Aluk to Dolo associated with tau-tau has been reformed in accordance with the level of noble family in Torajan communities.
Keywords: Functions and Types, Identity, Indonesia, Tau-Tau, Torajan.


Environmental right is a rising theory of environmental law and a new right in law. The article regards the sustainable development as the jumping-off point of the thought. It defines the unborn environmental right at first Which has important theoretic significance and far-reaching practical value to the admition of unborn environmental right in law. Then the significance discusses the property and the character ristics of to the admition of unborn environmental right. In the end, the article analyses three elements of the unborn environmental right by using the theory of law.


Wetlands in the Gironde estuary are both managed by public authorities with watershed intercommunal unions (Sibv) and private decision makers with landowner unions (Asp). Public decision maker aims at looking for a better economic efficiency in wetland management through the merger of several Sibvs. This paper analyses the conditions under which the merger of Asp at the same scale of Sibv can create efficiency gains in terms of cost management. Results show that sharing conflicts over these gains between the wetland-owners can prevent the formation of Asp unions.


Introduction The work to increase nesting by Kemp's ridley sea turtles (Lepidochelys kempii) at Padre Island National Seashore and in South Texas is a long-term, multi-faceted, and cooperative effort between the U.S. Geological Survey (USGS), National Park Service (NPS), and a variety of other entities in the USA and Mexico. This work has a focal area at the park. However, since Kemp's ridley is a highly migratory species, it has been necessary that these efforts extend well beyond the boundaries of Padre Island National Seashore. Kemp's ridley is the most critically endangered sea turtle species in the world. Most Kemp's ridleys nest along the Gulf of Mexico coastline in Mexico, near the village of Rancho Nuevo (U.S. Fish and Wildlife Service and National Marine Fisheries Service 1992). An estimated 40,000 Kemp's ridley females were filmed nesting at Rancho Nuevo on one day in 1947. Unfortunately, by the time that scientists discovered the location of the Rancho Nuevo nesting beach in the early 1960s, the number of nesting Kemp's ridleys had plummeted. Experimental project In 1978, it was feared that the Kemp's ridley would become extinct within a few years unless immediate steps were taken. A bi-national, multi-agency effort to save this species was initiated to augment the ongoing research and protection program at Rancho Nuevo. Part of the new effort was an experimental project to establish a secondary nesting colony of Kemp's ridley sea turtles in South Texas at Padre Island National Seashore, where some Kemp's ridley nests historically had been detected. It was thought that establishing a secondary nesting colony there would provide a safeguard for the species, so that if a political or an environmental catastrophe were to occur in Rancho Nuevo, there would be an area in the USA where Kemp's ridleys could nest and be protected. For the experimental project, attempts were made to imprint Kemp's ridleys to Padre Island National Seashore in hopes that they would return to South Texas as adults to mate and nest. From 1978-1988, Kemp's ridley eggs were collected in Rancho Nuevo, packed into Styrofoam boxes containing Padre Island sand, and shipped to Padre Island National Seashore for incubation (Shaver 1987; Shaver 1989a-b; Shaver and Chaney 1989; Shaver et al. 1989; Shaver and Fletcher 1992). The resulting hatchlings were released on the beach at Padre Island, were allowed to crawl down the beach and enter the surf, and were captured in the surf using aquarium dip nets. The captured hatchlings were shipped to the National Marine Fisheries Service Laboratory in Galveston, Texas, for rearing in captivity for 9-11 months—an experimental procedure termed "head-starting." Prior to release, each turtle was tagged for future recognition. Tagging methods varied for the different year classes, as new technology developed.


Recent advances in the development of functional materials and their applications in acoustic transducers are reviewed.New transducer designs based on magnetostrictive materials,relaxor ferroelectrics,piezoelectric composites,piezoelectric polymers,high temperature piezoelectric ceramics,and so forth are discussed.As a new development,acoustic transducers based on MEMS technology are also mentioned.


Co/Mo bilayered films have been successfully grown on MgO(100) and MgO(110) substrates by molecular beam epitaxy. According to the reflection high energy electron diffraction and X-ray diffraction measurements the crystal structure of the film depends on the orientation of the buffer and substrate. The growth of biaxial Co(112~0)/Mo(100) on MgO(100) and of uniaxial Co(11~00)/Mo(211) on MgO(110) substrates has been confirmed. The anisotropic magnetoresistance (AMR) is strongly influenced by the Co orientation which is altered by growth on Mo/MgO(100) and MgO(110). In Co(112~0)/Mo(100) on MgO(110) AMR is isotropic for all in-plane fields. However, for Co(11~00)/Mo(211) on MgO(110) we observed enhancement of AMR along the easy axis at 10 K.


Immortalization is an early and essential step of human carcinogenesis. Amplification of chromosome 20q has been shown to be a common event in immortalized cells and cancers. We have previously reported that gain and amplification of chromosome 20q is a non‐random and common event in immortalized human ovarian surface epithelial (HOSE) cells. The chromosome 20q harbors genes including TGIF2 (20q11.2‐q12), AIB1 (20q12), PTPN1 (20q13.1), ZNF217 (20q13.2), and AURKA (20q13.2‐q13.3), which were previously reported to be amplified and overexpressed in ovarian cancers. Some of these genes may be involved in immortalization of HOSE cells and represent crucial premalignant changes in ovarian surface epithelium. Investigation of the involvement of these genes was examined in four pairs of pre‐crisis (preimmortalized) and post‐crisis (immortalized) HOSE cells. Overexpression of AURKA (Aurora kinase A), also known as BTAK and STK15, by both real time‐quantitative polymerase chain reaction (RT‐QPCR) and Western blotting was detected in all the four immortalized HOSE cells examined while overexpression of AIB1 and ZNF217 was observed in two of four immortalized HOSE cells examined. Overexpression of TGIF2 and PTPN1 was not significant in our immortalized HOSE cell systems. The degree of overexpression of AURKA was shown to be closely associated with the amplification of chromosome 20q in immortalized HOSE cells. Fluorescence in situ hybridization (FISH) with labeled P1 artificial clone (PAC) confirmed the amplification of the chromosomal region (20q13.2‐13.3) where AURKA resides. DNA amplification of AURKA was also confirmed using semi‐quantitative PCR. Our study showed that amplification and overexpression of AURKA is a common and significant event during immortalization of HOSE cells and may represent an important premalignant change in ovarian carcinogenesis. © 2005 Wiley‐Liss, Inc.


Extraction of Drainage through the SRTM data using ArcGIS technique to delineate was attempted in this paper. This automated extraction tool will create the possible drainage pattern in the study area. The objective the model to obtain drainage network. Objective of this investigation is to compare the drainage extracted from Shuttle Radar Topography Mission (SRTM) data with matching from Google Earth image of Kodavanar River basin. The analysis reveals that the drainage extracted from the SRTM digital elevation model (DEM) is having an area of 2254.65 km. This study reveals the importance peculiarity of drainage network derived from the SRTM using the Arc Hydro Tool.


An Intrustion Detection System with dual redundant monitor and control units, redundant data busses, and optional redundant sensor capabilities is described. A new proprietary data communications network designed specifically for security systems provides for either redundant wire or dual redundant fiber optic data loop networks.


In the framework of Network Morphology (Corbett & Fraser 1993; Fraser & Corbett 1995, 1997), realizational models of natural-language morphology have customarily been defined in DATR, a language for lexical knowledge representation designed and implemented by Roger Evans and Gerald Gazdar (Evans & Gazdar 1989a,b, 1996). We show that certain kinds of morphological analyses that are wholly consonant with the general program of Network Morphology are not directly expressible in existing forms of DATR; we therefore propose and exemplify KATR, an extension of DATR whose motivation is to accommodate these desired kinds of morphological analyses. The proposed modifications are motivated by the need to represent a word's morphosyntactic property as essentially unordered; to account for the incidence of nonlocal sandhi phenomena; to define common patterns of inflectional syncretism; and to allow certain morphological rules to apply in "expanded mode" (Stump 2001). Although KATR affords morphological definitions that are more streamlined than those afforded by DATR, its generative capacity is no greater than that of DATR, since both languages are capable of emulating a Turing machine.


Owing to short of the supervision's preciseness and control, embezzlement case in corporation high frequency happened recently,accordingly, the finance market method was disturbed, and the investor, credit mechanism and the corporation of exchange were suffered from damage. At the same time, it has prodigious badness infection to the capital market's improvement. It is the Co. supervisor's social responsibility that deals in the corporation, and maintains the rights and interests of the stockholder, credit mechanism and the exchanging corporations. Government is the main pusher that maintains the normal operation of the capital market, perfects and stabilizes the method of the finance market to intendance and management of the enterprise, strengthen the treatment and drive the manipulative system with in the corporation.


For the development of seedling production techniques of the freshwater crab Eriocheir japonicus, the effects of salinity and temperature on the growth of larvae of the crab were studied. Embryos hatched out as zoea larvae were measured 0.421 mm in average carapace length. Five zoea stages needed 16-26 days for metamorphosis from zoea to megalopa at and . The average carapace length of the 5th zoea was 1.16 mm and that of the megalopa larvae was 1.89 mm. Each zoea stage could be identified based on both the number of plumosed seatae on the exopodite of maxilliped, and the number of spines on the posteroinner margin of tel son and also based on the rudimentary pleopods appearence. Zoea larvae fed rotifers and Artemia nauplii were healthy and metamorphosing rate from zoea to megalopa was . The relationship between larval period (Y in days) and water temperature is expressed as Log Y = 3.8604-1.91735 LogX. Water temperature and salinity ranges for better survival and metamorphosis of the larvae were , respectively. The duration of larval stages tend to longer as salinity levels deviated from optimum particulaly at lower end. All zoea larvae did not survive in freshwater.


The article describes the theoretical basis of apply of GM(1, 1) moesls in spprts forecast, introduces the main content and the using methods of GM(1, 1) models,and studies carefully the forecast of GN(1, 1) models in sports and discusses the limit ed factors of application by combining with male hammer thrower Bi Zhong's best performance. The purpose of it is to popularize apply of GM(1, 1) in sports and make it serve for sPOrts scientifically.


Liquid-crystal devices (LCDs) offer a potential route toward adaptive optical components for use in the<2 THz band of the electromagnetic spectrum. We demonstrate LCDs using a commercially available material (E7), with unbiased birefringence values of 0.14-0.18 in the 0.3-4 THz band. We exploit the linear dichroism of the material to modulate the emission from a 3.4-THz quantum cascade laser by up to 40%, dependent upon both the liquid-crystal layer thickness and the bias voltage applied.


Investigation of the hot spark heating is now possible with a 10‐ps temporal resolution. Hot spark heating was improved with the increased stand‐off distance and RT stabilized implosion mode. Irradiation nonuniformities have been reduced by precise power balancing of the beams and by the partially coherent light technique. Improved spark heating in the deceleration phase resulted in enhanced neutron production up to the second bounce yield.


Objective To investigate the characteristics and related risk factors of patients with lymphoma complicated with tuberculosis (TB), the possible pathogenesis and effective therapy. Methods Twenty-one cases of lymphoma combined with TB were retrospectively analyzed by clinical manifestations,pathological features,diagnostic methods,treatments and prognosis.Results Six cases were diagnosed as TB after the diagnosis of lymphoma,5 cases of which were undergoing chemotherapy for lymphoma; 13 cases were diagnosed as lymphoma after TB,including 6 of 10 obsolete pulmonary TB were reactivated during undergoing chemotherapy. Two cases were diagnosed lymphoma and TB simultaneously. Six cases of 21 cases were Hodgkin lymphoma, whereas the other 15 cases were non-Hodgkin lymphoma. Conclusion TB and lymphoma may exist in the same patient in areas where TB is endemic; among this population,the proportion of Hodgkin lymphoma was higher than in the general population.Therefore,the possibility of TB reactivation when undergoing chemotherapy must be focused on.

Key words:
Lymphoma; Tuberculosis


Abstract 3704 Obinutuzumab (GA101) is the only type II glycoengineered and humanized monoclonal anti-CD20 antibody to enter clinical trials. The efficacy and safety of GA101 in combination with cyclophosphamide/doxorubicin/vincristine/prednisone (G-CHOP) or fludarabine/cyclophosphamide (G-FC) in patients with CD20+ relapsed/refractory B-cell follicular lymphoma has been evaluated in an open-label, multicenter, randomized Phase Ib study (BO21000). Response rates were similar for G-CHOP (94%) and G-FC (93%) (Davies et al, EHA 2011). Studies in patients with CD20+ malignancies treated with GA101 monotherapy have suggested that responding patients eliminate GA101 more slowly than nonresponders (Meneses-Lorente et al, ASH 2010). Here we describe results from BO21000, exploring GA101 pharmacokinetics (PK), exposure and response in patients receiving concomitant chemotherapy. Patients received 6–8 cycles of G-CHOP or 4–6 cycles of G-FC. The choice of chemotherapy and number of cycles were at the discretion of the investigator. After stratification by chemotherapy backbone, patients were randomized to receive one of two GA101 dosing regimens: 1,600 mg on Days 1 and 8 of Cycle 1, then 800 mg on Day 1 of subsequent cycles (1,600/800 mg; G-CHOP, n=14; G-FC, n=14), or 400 mg on Days 1 and 8 of Cycle 1 and on Day 1 of subsequent cycles (400/400 mg; G-CHOP, n=14; G-FC, n=14). G-CHOP or G-FC were administered every 21 or 28 days, respectively. Serum samples were taken prior to and directly after each infusion, for all treatment cycles, between Days 1 and 21 of Cycle 1 (G-CHOP) and Days 1 and 28 of Cycle 1 (G-FC), and for several days (up to 32) after the final cycle. Serum levels of GA101 were measured by ELISA. GA101 serum concentrations were higher in the 1,600/800 mg cohort compared with the 400/400 mg cohort, regardless of chemotherapy arm (Figure 1). Notable differences in PK profiles were observed in the clearance of GA101 in later cycles and varied between G-CHOP and G-FC. For the 400/400 mg G-CHOP cohort, steady state was reached by Cycle 2, with Cmax values of approximately 200–250 μg/ml and Cmin values of around 100 μg/ml. In contrast, Cmax and Cmin values for the 1,600/800 mg G-CHOP cohort were stable from Cycles 2 to 4 (600 and 350 μg/ml, respectively), but increased slightly from Cycles 5 to 7. For the 400/400 mg G-FC cohort, steady state was reached by Cycle 2 and maintained for the rest of treatment. In the 1,600/800 mg G-FC cohort, steady state was reached by Cycle 2; GA101 concentrations declined slightly from Cycles 3 to 6. Similar approximate Cmax values of 580 and 600 μg/ml in the 1,600/800 mg G-FC and G-CHOP cohorts, respectively, were seen in Cycle 3; by the end of treatment these were approximately 400 μg/ml (Cycle 6, G-FC) and 675 μg/ml (Cycle 8, G-CHOP). Treatment cycle duration for G-CHOP was shorter than for G-FC; thus, lower GA101 serum concentrations in the G-FC cohort would be anticipated. In contrast, Cmax and Cmin values for the 400/400 mg cohorts were similar for both treatment arms, being around 200 μg/ml and 100 μg/ml, respectively. In the 1,600/800 mg G-CHOP cohort patients who were complete responders (CRs) had higher GA101 concentrations after the second dose, with these concentrations maintained over the remaining cycles (Figure 2). Indeed, CRs demonstrated an increase in GA101 concentration over time, whereas in patients with a partial response it remained the same from Cycle 2 onwards. Similar trends were seen for the 400/400 mg G-CHOP cohort, and for both dose levels of the G-FC cohort, with higher concentrations observed in CRs. In conclusion, GA101 serum concentrations were higher in the 1,600/800 mg cohorts compared with the 400/400 mg cohorts when dosed with either G-CHOP or G-FC. Furthermore, GA101 serum concentrations appeared to be higher in the 1,600/800 mg G-CHOP cohort compared with the 1,600/800 mg G-FC cohort. Response data indicate that patients with the best clinical response have higher GA101 serum concentrations and appear to eliminate GA101 more slowly than other patients. This is consistent with observations from monotherapy studies and may reflect the impact of shrinking tumor burden upon the clearance of GA101, which will be subject to further analyses. Disclosures: Carlile:Roche: Employment. Meneses-Lorente:Roche: Employment. Wassner-Fritsch:Roche: Employment. Hourcade-Potelleret:Roche: Employment. Wenger:Roche: Employment. Cartron:Roche: Consultancy, Honoraria. Vitolo:Roche: Membership on an entity9s Board of Directors or advisory committees. Morschhauser:Roche: Honoraria; Celgene: Consultancy, Honoraria.


The aim of this study is to identify a specific degradation of concrete that has been observed in bridge decks made of reinforced concrete (RC). To control the phenomenon, fundamental studies were conducted. Compressive loads and external water pressure were cyclically applied to submerged concrete cylinder specimens with different pre-loading and restraint conditions. The turbidity of the water in the tank was generally observed during the loading, and the pH of the turbid water steadily increased as the number of cycles increased. Thereafter, fine aggregates without a cement matrix were found on the inner surfaces of split specimens. These phenomena were quantitatively analyzed, and the analyses suggested that cyclic water pressure acted on the inside of pre-cracked specimens and washed out their cement matrix. The degradation of a rough cracked surface was also examined using the cyclic shear test, with/without a water supply to the crack. The shear slip and the orthogonal displacement were clearly amplified with an increase in the number of cycles when the water supply was present. The mechanical properties of cracked concrete with water in shear was discussed in accordance with that of liquefaction. These fundamental studies could help to determine the acceleration factors of the degradation and provide certain thresholds for practical use.


In the virtual reality environment collision examination is domain and so on computer graphics,computation geometry,simulation modeling and robot way plan important questions.This paper discussed the collision to examine the optimized method which in the process the algorithm and the surrounding box tree's overlap test time as well as the collision examined,further enhanced the efficiency which the collision examined.


Originally pitting Great Britain against the US in 1927, and for decades a largely one-sided rivalry, the former's request for European help in 1979 changed the complexion of the Ryder Cup as a sporting phenomenon. Unseen in any other major sporting arena, the growing undercurrent of European-ness (the mateship between Scot and Swede, the green-side chants of "Yoo-rop! Yoo-rop!") is ripe for further investigation. The lines were drawn long ago: internationalist GB v exceptionalist US. Born of a uniquely competitive newspaper market as well as a region more accustomed than any other to supporting national sporting teams, British journalists are renowned/notorious for their lack of bias and, indeed, fondness for ridicule; beyond the Olympics, for which the US media cheerleading is seldom less than one-eyed, their counterparts rarely have an opportunity to report the exploits of a representative side. And when they do, as at the World Baseball Classic, their editors, on the whole, don't send them. Focusing primarily on newspapers, this paper will analyse whether these accepted wisdoms persist while addressing whether anti-Americanism trumps the "Yoo-rop" factor.


For the electronics industry, the silicon powder residue, in the form of an aqueous dispersion, is an environmental and economic issue. Therefore, the objective of this work was to analyze the characteristics of such material, through a study case in a semiconductor company, aiming to close the production cycle. The aqueous silicon dispersion which is generated by the silicon wafer grinding and sawing systems was characterized by physical methods and by optical microscopy. This non-product was used in cement test specimens which were submitted to compressive strength tests to determine a potential improvement due to the addition of micro-silica in comparison with regular cement. The results showed that there was a significant increase in the compressive strength indicating the technical feasibility of using this type of non-product from the semiconductor industry in cement fabrication. Although the study showed evidence about the technical feasibility of the use of this non-product, in order to have a viable industrial symbiosis for both companies, the logistics aspects will also play a determinant role to encourage mutual cooperation between the companies.


Correlatively inhibited lateral buds on potato tubers were supplied with various nutrient solutions through the surfaces of leaf primordia. The media, which also supported the growth of isolated buds in tissue culture, stimulated the growth of the dominant (growing) sprouts but the inhibited buds were not induced to grow. These findings suggest that inhibition was not due to a shortage of nutrients. The neutral fraction of the ether extract from potato tubers bearing inhibited sprouts contained a substance or substances capable, at physiological concentra tions, of inhibiting the growth of buds both in situ and when isolated. Buds on eyepieces were not inhibited when supplied with a tissue-culture medium as well as the neutral fraction. The latter contained both growth-inhibiting and growth promoting substances. The inhibitor complex was partially purified. It was soluble in water and ether and was most unstable. When treated with fluorescein followed by bromine it gave a characteristic reddish-brown fluorescence. Attempts to establish its chemical nature were unsuccessful. The available evidence indicated that the substance(s) was effective in preventing the extension of potato buds at concentrations approxi mating to those found in situ and that it disappeared from tuber tissue within 24 h of removing the growing sprouts. It is suggested that this complex, which is rapidly metabolized in tissue, is the prime component involved in apical dominance. Nutrient supply does not appear to be directly involved although a ready supply of nutrients can partially offset the effect of the inhibitor.


The background of research is that people always have different motivation to work. Some people are motivated to work something because it gives them a lot of money although such work may be illegal. Some others are motivated to work due to the seeking for security or safety although it involves working in distant. All of these are determining the achievement of performance in working in the company. Research type is explanatory research. Based on the result of research and discussion, it is concluded that the demand for achievement, the demand for power and the demand for affiliation have simultaneous and partial influence on employee performance at PT. PLN Persero APJ Malang. This result indicates that higher motivation to work, due to the demand for achievement, the demand for power and the demand for affiliation, will increase employee performance. The lower motivation to work, either through the demand for achievement, the demand for power and the demand for affiliation, can decrease employee performance.


I used supramolecular self-assembling cyanine and the polyamine spermine binding to Escherichia coli genomic DNA as a model for DNA collapse during high throughput screening. Polyamine binding to DNA converts the normally right handed B-DNA into left handed Z-DNA conformation. Polyamine binding to DNA was inhibited by the supramolecular self-assembling cyanine. Self-assembly of cyanine upon DNA scaffold was likewise competitively inhibited by spermine as signaled by fluorescence quench from DNA-cyanine ensemble. Sequence of DNA exposure to cyanine or spermine was critical in determining the magnitude of fluorescence quench. Methanol potentiated spermine inhibition by >10-fold. The IC{sub 50} for spermine inhibition was 0.35 {+-} 0.03 {micro}M and the association constant Ka was 2.86 x 10{sup -6}M. Reversibility of the DNA-polyamine interactions was evident from quench mitigation at higher concentrations of cyanine. System flexibility was demonstrated by similar spermine interactions with {lambda}DNA. The choices and rationale regarding the polyamine, the cyanine dye as well as the remarkable effects of methanol are discussed in detail. Cyanine might be a safer alternative to the mutagenic toxin ethidium bromide for investigating DNA-drug interactions. The combined actions of polyamines and alcohols mediate DNA collapse producing hybrid bio-nanomaterials with novel signaling properties that might be useful inmore » biosensor applications. Finally, this work will be submitted to Analytical Sciences (Japan) for publication. This journal published our earlier, related work on cyanine supramolecular self-assembly upon a variety of nucleic acid scaffolds.« less


The work described in this paper refers to the production of laminate composite materials reinforced with portuguese wool fibres. A mechanical characterisation in tension, flexion and impact of wool fibres reinforced composite materials is made. A brief description of the production and test setups of the wool fibres reinforced composite materials is made. The use of these animal fibres is pointing also to the ecological problem of composite materials recyclability.


Recently, a lot of attention has been paid to ultra wideband (UWB) wireless communications systems due to its potential to reach data rate in wireless communications. A UWB signal is defined as that whose bandwidth either surpasses 25% of its spectrum's center frequency or exceeds 1.5 GHz. The UWB communication systems is often referred to as impulse radio since such ultra wideband signal is composed of sub-nanosecond pulses. In addition to possibly enabling the implementation of high-speed wireless access with over 1 Gbit/s data-rules, UWB systems also have the potential to simplify the RF circuitry of the transceivers and lower the transmit power. Previous UWB-IR system proposals have used trains of Gaussian pulses at transmission, resulting, at the receiver. in waveforms known as the monocycle. In those schemes, a number of pulses are needed to transmit 1 bit of information. In this work, a system that transmits several bits per pulse, aimed at enhancing data rate, is studied. The pulse shape used on the UWB system is also studied. UWB pulses based on modified Hermite polynomials (MHP) have been proposed before. These pulses are orthogonal at the transmitter, but not at the receiver due to the differentiation effect of both transmit and receive antenna.


Special grip-strength meter designed for accurate, reproducible measurement of hand rehabilitation. Four strain gauges connected in Wheatstone bridge to measure deflection caused by gripping hand. Compressive force exerted by hand transmitted to measuring beams. Beams therefore deflected or strained, and mechanical strain sensed by strain gauges and converted into electrical signal. After amplification and conditioning, signal displayed on LED as measure of gripping strength of hand.


Gönderilme tarihi: 27.02.2016 Kabul tarihi: 11.03.2016 Abstract Synovial cysts develop as a result of herniation in the synovial membrane of the facet capsule. Synovial cysts, which are seen mostly in the 6th and 7th decades of life, are rarely seen in intraspinal, extradural lesions which lead to lower back pain and radiculopathy. Although they can be seen throughout the spinal region, the most common location is the lumbar L4-L5 disc space. It is very rare that location is in the cervical or thoracic regions and may be due to myelopathy in these regions. As those showing location in the lumbar area are close to the nerve root, radiculopathy may occur as a result of pressure on the nerve root. Diagnosis is made from a thick cystic structure seen adjacent to the facet joint on computed tomography and the determination of the capsule with contrast on magnetic resonance imaging. While conservative or surgical methods can be applied in treatment, the most commonly preferred method is surgery. In this paper, the case is presented of a 68-year old male patient with severe left leg pain, who was diagnosed with synovial cyst at the L4-L5 level. In elderly patients with complaints of radiculopathy, synovial cysts must be considered in the differential diagnosis.


Despite known differences between reading and listening in the brain, recent work has shown that text-based language models predict both text-evoked and speech-evoked brain activity to an impressive degree. This poses the question of what types of information language models truly predict in the brain. We investigate this question via a direct approach, in which we eliminate information related to specific low-level stimulus features (textual, speech, and visual) in the language model representations, and observe how this intervention affects the alignment with fMRI brain recordings acquired while participants read versus listened to the same naturalistic stories. We further contrast our findings with speech-based language models, which would be expected to predict speech-evoked brain activity better, provided they model language processing in the brain well. Using our direct approach, we find that both text-based and speech-based language models align well with early sensory regions due to shared low-level features. Text-based models continue to align well with later language regions even after removing these features, while, surprisingly, speech-based models lose most of their alignment. These findings suggest that speech-based models can be further improved to better reflect brain-like language processing.


Several percolation-based schemes for calculating the effective conductivity of complex, correlated media with bimodal distributions of the local conductivity are compared with numerical simulations. A means of calculating the correlation length is employed to distinguish regions of validity of the calculations. In most cases, a rather simple scaling formulation closely related with universal scaling is found to perform best. This scaling formulation employs geometric mean values of the modes of the conductivity distribution as scale factors.


Based on resolution on the positive terms for equations of higher order, an iterative technique to find a positive real root of equations of higher order with real coefficients is given by New ton's method. The technique possesses an advantage of free condition for choos ing initial iterative values. It can be improved to the iteration method with global convergence for finding all real roots.


Objective To observe the effect of simvastatin with small dose and large dose on serum lipid and Crouse plaque integral in patients with hyperlipidemia and carotid artery plaque,and to evaluate the clinical efficacy of high-dose simvastatin on hyperlipidemia and atherosclerosis.Methods Sixty patients with hyperlipidemia and carotid artery plaque were divided into treatment group and control group.Patients in treatment group received simvastatin 80 mg per night,oral; and patients in control group received simvastatin 20 mg per night,the course was 20 weeks.The Crouse plaque integral,lipids and other related indicators were detected by color Doppler ultrasound before and after treatment,the safety of high-dose simvastatin medication was determined by laboratory tests.Results clinical trials showed that Crouse plaque integral and lipid level significantly decreased (P =0.032).Compared with the control group,the treatment group can significantly lower blood lipids,reduce the Crouse plaque score,and its efficacy was better than control group (P =0.021).Conclusions High doses of simvastatin tablets has the effect of stabilizing carotid plaque and reducing lipid levels,and its efficacy is significantly better than control group,and it is safe.

Key words:
Simvastatin tablets ;  Hyperlipidemia ;  Atherosclerosis ;  Carotid artery plaque


We investigated the physico-chemical and sensory characteristics of Kimchi made with red pepper that was washed and mashed. The pH of juice from Kimchi made with red pepper powder was the highest on the day of Kimchi preparation. In the case of Kimchi made with mashed red pepper, the pH of juice and liquid was lower than that of other samples. A similar decrease in pH of juice and liquid was observed up to the second week of fermentation, but the significant difference between both samples wasn't found. The total acidity of Kimchi with mashed red pepper was significantly increased during early fermentation, but was similar during the second week, compared with that of Kimchi with red pepper powder. From the third week of storage, both juice and liquid from Kimchi made with red pepper powder was relatively increased. L and a value of liquid was highest in the case of Kimchi made with mashed red pepper, but b value was lowest during fermentation. In the case of organic acids, acetic acid and lactic acid contents were increased in Kimchi made with mashed red pepper while fermentation progressed. In addition, citric acid content was constant up to the second week in Kimchi made with mashed red pepper but from the third week wasn't detected in both Kimchi made with mashed red pepper and Kimchi made with red pepper powder. In the case of QDA(Quantitative Descriptive Analysis) profiles, the values of Kimchi made with mashed red pepper were significantly higher than those of Kimchi made with red pepper powder in respect to redness, pungency and fresh flavor immediately after the preparation of Kimchi and during the second week of fermentation, but during the fifth week the values were higher in respect to redness and fresh flavor of Kimchi. Appearance and overall acceptability was remarkably increased in Kimchi made with mashed red pepper, compared with that of Kimchi made with red pepper powder immediately after pickling, during the second and the fifth week of fermentation. Therefore, these results indicate that mashed red pepper increased more citric acid content, L and a value of Kimchi in comparison with red pepper powder, resulting in the good effects on overall acceptability due to the significant increase of redness and fresh flavor.


This paper describes a preconditioned conjugate gradient method that can be effectively implemented on both vector machines and parallel arrays to solve sparse symmetric and positive definite systems of linear equations. The implementation on the CYBER 203/205 and on the Finite Element Machine is discussed and results obtained using the method on these machines are given.


Small business owners have a number of things that demand their attention. Yet, virtually all of them are concerned with how their business is doing. Many suggestions have been made in an effort to address that concern. In this paper, a straight-forward approach is suggested, which is not overly complicated yet not overly simplistic either. With the use of five financial measurements, the busy small business owner can gain a keen appreciation of how the business is doing. The measures serve as indicators of various aspects of the business and, at the same time, present a solid overall picture. Further action is then dependent on the time, inclination, and resources of the owner.


Abstract In this study, fluorescent carbon dots (CDs) were synthesized using hydrothermal treatment of coconut sap (neera). The as-synthesized material exhibited excellent fluorescence properties with strong emission at 479 nm once excited over 370 nm. X-ray Diffraction (XRD) pattern revealed that the CDs were poor crystalline in nature. Fourier Transform Infrared spectra (FTIR) and X-ray photoelectron spectra proved the existence of carbon and oxygen on the surface of the CDs. Microscopic analyses confirmed that the spherical shape of CDs was aggregated into carbon clusters. Also, the synthesized CDs were used to detect silver ion in aqueous solutions and showed a detection limit of 0.26 µM. The synthesized CDs can be used as an eco-friendly material in fluorescent probes for metal ion detection.


Biomaterials and related areas are steadily gaining importance in both fundamental and applied science. This growth has also been visible at the Materials Science and Engineering (MSE) conference organized by the Deutsche Gesellschaft für Materialkunde (DGM). In August 2010 in Darmstadt, Germany, ''BioMat'' was a major topic at the MSE with more than one hundred submitted contributions to the symposia: ''bio-inspiration'', ''interfaces'' and ''biomaterial applications''. One reason for the overwhelming interest in the topic ''BioMat'' is the increasing need to achieve desired structure-function relationships of biomaterials in biological systems. At the same time advanced engineering strategies at the molecular, microand macro-scale have become available. A key area of interest is the biomaterials' surface, which is crucial for the biological response. The MSE topic ''Biomat'' showed that a more profound understanding of the mechanisms on a materials surface in contact with a biological system is necessary. These mechanisms include the reaction of a biological system to a materials surface at different time and length scales, and also surface modifications induced by the biological environment, such as degradation. Recent advances in optimizing the biological response by several strategies have been demonstrated within the symposium ''interfaces''. Examples were lectures on a more detailed picture of how cellular behavior is affected by the surface-chemistry and -topography on tailored nanoand micro-structured surfaces. The vital role of surface-biomolecule interactions and electrochemical signaling in biological reactions was stressed. Further strategies presented at the MSE 2010 included the application of functional coatings with drug release capability, and also biomimetic concepts to create bioactive implant surfaces. Peptide-based biohybrids may ideally fill the gap between engineered synthetic material surfaces and the biological environment. A challenge for future developments is the integration of biomimetic design principles into biohybrid materials and their application as coatings of implants or advanced scaffolds for tissue engineering. This Special Issue of Advanced Biomaterials contains seven peer reviewed articles based on selected lectures presented at the MSE conference in Darmstadt in August 2010. For instance, M. Müller reports advances in biopolymer polyelectrolyte multilayers to create protein active or protein inert biomedical surfaces. A. Boccaccini demonstrates in his article that the addition of TiO2 nanoparticles to thermoplastic elastomers can enhance the adhesion and spreading of embryonic stem cell-derived cardiomyocytes without affecting the functional activity of spontaneous beating. R. Dringen discusses the successful cellular uptake of citrate-coated, magnetic iron oxide nanoparticles into astrocyte brain cells. As one immediate result of the success of the ''BioMat'' topic, the DGM is organizing the international symposium ''EURO BioMat'' which will take place in Jena, Germany, on the 13.-14. April 2011. This symposium will be an ideal opportunity for engineers, materials scientists, physicists, chemists and biologists as well as medical professionals to discuss newest developments in this exciting interdisciplinary field. Detailed information is available from the symposium website http:// www.dgm.de/dgm/biomat/. The DGM organizers and the EURO BioMat program committee are looking forward to welcoming you in April 2011 in Jena.


Abstract  Visceral perception and secondary peristalsis evoked by distension of the duodenum were studied in 10 healthy volunteers. An impedance planimetric probe for cross‐sectional area (CSA) measurements inside a balloon and with three pressure channels was used. Balloon distensions were performed in the fed state with or without the administration of the antimuscarinic drug butylscopolamine. A modified questionnaire was used to assess the nonpainful and painful sensations. The total tension (Ttotal) and the passive tension (Tpassive) were determined from the distensions without and with the administration of butylscopolamine, respectively. The active tension (Tactive) was Ttotal – Tpassive. The stepwise balloon distensions induced the first sensation at a volume of 33 ± 3 mL. After administration of butylscopolamine the first sensation appeared at 42 ± 1 mL. The perception score (PS) revealed an approximately linear increase as function of volume, CSA, pressure and tension after the first sensation. Butylscopolamine resulted in significant changes in PS score as function of volume, CSA and strain, but not as a function of pressure and tension. The frequency of the secondary peristalsis increased to the highest value (8.2 ± 0.8 contractions min−1) at a volume of 21 mL. Butylscopolamine almost abolished the distension‐evoked motility. Ttotaland Tpassiveincreased nonlinearly as a function of volume, whereas Tactiveincreased up to a distension volume of 33 mL and then decreased at higher volumes. Hence, the conventional length–tension diagrams as known from studies of smooth muscle strips in vitro can be reproduced in the human duodenum in vivo. This new way of studying intestinal sensation and motility may prove to have both basic and clinical importance as both passive tissue structures and the sensorimotor function are tested.


With the exception of Assembling Objects (AO), a spatial ability test used only by the Navy in enlisted occupational classification, the Armed Services Vocational Aptitude Battery (ASVAB) is academic and knowledge-based, somewhat limiting its utility for occupational classification. This article presents the case for integrating the AO test into military classification composites and for expanding the breadth of ASVAB content by including a former ASVAB speed/accuracy test, Coding Speed (CS). Empirical evidence is presented that shows AO and CS (a) increment the validity of the ASVAB in predicting training grades for a broad array of occupations, (b) reduce adverse impact defined as test score barriers for women and minorities, and (c) improve classification in terms of matching recruits to occupations. Some cognitive theory is presented to support AO and CS, as well as nonverbal reasoning and working memory tests for inclusion in or adjuncts to the ASVAB.


17 The Eocene was characterised by ―greenhouse‖ climate conditions that were gradually 18 terminated by a long-term cooling trend through thefrom middle toand late Eocene. This 19 long-term trend was determined punctuated by several large-scale climate perturbations that 20 culminated in a shift to ―ice-house‖ climates at the Eocene-Oligocene Ttransition. 21 Geochemical and micropaleontological proxies suggest that tropical-to-subtropical sea22 surface temperatures persisted into the late Eocene in the high-latitude Southwest Pacific 23 Ocean. Here, wWe present radiolarian microfossil assemblage and foraminiferal oxygen and 24 carbon stable isotope data from Deep Sea Drilling Project (DSDP) Sites sites 277, 280, 281, 25 and 283 and Ocean Drilling Project (ODP) Site 1172 from the middle Eocene to early 26 Oligocene (~40–33 Ma) to identify significant oceanographic changes in the Southwest 27 Pacific across through this major climate transition (~40–30 Ma) in Earth's climate history. 28 We find that Tthe Middle Eocene Climatic Optimum at ~40 Ma, which is truncated but 29


Purpose
The purpose of this paper is to uncover career-related issues that high-skilled female immigrants face and their strategies for rebuilding their careers upon migration for a diverse range of reasons including following a spouse, furthering education and self-initiated expatriation.

Design/methodology/approach
Using grounded theory to explore this topic, the authors performed 14 in-depth interviews with female immigrants that fit pre-determined inclusion criteria for high-skilled (e.g. educated, gainfully and professionally employed). The study context of immigration is the USA, and the authors performed interviews with high-skilled immigrants from Turkey – an underrepresented nation in the US migrant population.

Findings
Content analysis of in-depth interviews revealed five primary theoretical themes that captured the career experiences of these individuals: non-linear career entry, career orientation, strong commitment and will to succeed, socialization patterns at work and support network. Integrating these findings with theories on adult learning, the authors developed an experiential learning model of career reconstruction among high-skilled immigrants.

Originality/value
This study contributes to the global mobility literature by developing an experiential learning theory of careers and taking a gendered perspective to the career experiences of high-skilled female immigrants. It answers the questions: what are the individual and situation factors associated with career success among high-skilled female immigrants? and what is the process that high-skilled immigrants go through to rebuild their careers?


Following the Greek tradition, the Roman historians included oratical speeches of the characters in their plays, by alterning the oratio recta, which reproduced the words of the characters in a supposedly literal way, and the oratio obliqua, characterized by the shift of the speech in accordance with the time-spatial coordinates of the statement itself. This method of discursive reproduction had an unusual development in the latin language since it needed no reporting verb before every new statement. A review of the Roman historiography seem to suggest the obvious differences of use between the different times and the various historians; some of them didn´t include any speech in their plays, many more limited to the oratio recta, and among those who used the latin reported speech there´s a wide variety, from the high point of the Iulius Caesar Commentarii to the total decline at times of Tacitus, the last historian who uses oratio obliqua in the interspersed speech of his play. Even from the writers whose play is damned by the textual transmission some conclusions can be drawn from some passage or from indirect information.


In December 2019, in Wuhan, China there were a series of cases of pneumonia that changed lives as we know it until now, since the Covid-19 pandemic has had an impact on all areas of human life due to the isolation and social distancing measures taken by different governments to stop their expansion. The food supply chain is complex and has been affected at all levels, from the field to the consumer, especially in countries with fewer economic resources. In Paraguay, workers linked to the food supply chain have been considered essential and therefore their work has not stopped, this has helped to ensure that to date there has been no food shortage. The resilience of the chain is necessary but in addition to this, governments must take measures that ensure not only the health of workers who are part of the production, industrialization, distribution and sale of food, but also have the obligation to guarantee that the products foodstuffs are of sufficient quality and safe.


ZnO films were deposited on glass substrates by magnetron RF-sputtering. An accurate determination of the optical constants of these films is extremely important prior to its application in optical devices and spectroscopic ellipsometry provides a reasonably accurate method for the determination of optical constants of thin films. In this study, we present the results gained by analyzing spectroscopic ellipsometry of ZnO thin film combined with comparison of transmission spectroscopy measured on a UV-VIS-NIR spectrophotometer. Ellipsometry data have been fitted with a model including a glass substrate and a ZnO film plus a surface void layer on top. From this fitting the refraction index (n), extinction coefficient (k) and thickniess (d) of the sputtered ZnO films were determined. By using the gained n, k and d values the transmission spectrum was theoretically calculated and compared with the experimentally obtained transmission one. As a result of the combined spectroscopic ellipsometry and transmission analysis, there was the good correlation in comparison.


We quantitatively analyzed the dendritic and dendritic spine development on basal and oblique dendrites of large layer IIIc pyramidal neurons of the prospective prefrontal area 9 in the brains of three infants with Down syndrome (DS) and five age-matched-controls over the period from 32 weeks postconception to the 7th postnatal month. By using Neurolucida 3.1 software on rapid Golgi impregnated slices, 9–10 neurons were three-dimensionally reconstructed. There were no significant differences in the pattern of the dendritic and spine development between the basal and apical oblique dendrites. The DS subjects did not depart significantly from the developmental curve of the control subjects. Our data showed that large and significant segment outgrowth, in parallel with dendritic elongation occurred during a limited period of time, between 36 weeks postconception and the first postnatal month. Dendritic spines appeared at the time of birth and their density continued to increase up to the age of 7 months. During the first postnatal month long thin spines and filopodia-like protrusions predominated, but the spines later changed their morphology to a more mature form. No differences in the spine morphology were qualitatively observed between the DS infants and the age matched controls. This data suggests that intensive formation of cortical circuitry occurs on large layer IIIc pyramidal neurons during perinatal period and is not disturbed in DS infants. Consequently, this could be a biological potential to mitigate psychomotor impairment in DS patient.


We present a learning-based method, namely GeoUDF,to tackle the long-standing and challenging problem of reconstructing a discrete surface from a sparse point cloud.To be specific, we propose a geometry-guided learning method for UDF and its gradient estimation that explicitly formulates the unsigned distance of a query point as the learnable affine averaging of its distances to the tangent planes of neighboring points on the surface. Besides,we model the local geometric structure of the input point clouds by explicitly learning a quadratic polynomial for each point. This not only facilitates upsampling the input sparse point cloud but also naturally induces unoriented normal, which further augments UDF estimation. Finally, to extract triangle meshes from the predicted UDF we propose a customized edge-based marching cube module. We conduct extensive experiments and ablation studies to demonstrate the significant advantages of our method over state-of-the-art methods in terms of reconstruction accuracy, efficiency, and generality. The source code is publicly available at https://github.com/rsy6318/GeoUDF.


World Health Organization (WHO) South‐East Asia region (SEAR) is home to nearly 90% of global smokeless tobacco (SLT) users that is over 250 million from among 300 million SLT users in the world. SLT is chewed, sucked, snuffed orally and nasally, sipped or gargled and applied on teeth and gums as dentifrice. Myriad varieties of SLT products for each of these are available in countries of the WHO SEAR. Among all SLT products, traditionally betel quid has been the most commonly used product in most countries, including Bangladesh, Maldives, Myanmar, Sri Lanka, and Thailand. However, Khainee, a mixture of tobacco with slaked lime, is used most commonly in India and Nepal. Nearly, 5% of the adult population use tobacco as dentifrice in Bangladesh and India. Most of the SLT products used in countries of SEAR are found to be mutagenic, carcinogenic, cardiotoxic and contain heavy metals.


For a Lie algebra L over an algebraically closed field f of characteristic zero, Krempa shows in [5] that every subspace invariant under all automorphisms of L is also invariant under all locally finite derivations of L. From this result we can easily derive the proposition that for a Lie algeie.ra L given above, A which is one of the relations si, asc, desc, lsi, ser and for any class X, every subalgebra generated by all zdsc-subalgebras of L is invariant under all locally finite derivations of L. In this paper we present some classes se for which the above proposition holds for a locally fini'te Lie algebra L without the assumption that f is algebraically closed.