Background: The established classification of acute lymphoblastic leukemia (ALL) does not cover all high-risk patients because of the difficulty in detecting novel or rare structural variants (SVs). Furthermore, many SVs and formed gene fusions have adverse prognostic effects on hematological malignancies. This study aims to investigate SVs in 22 patient-derived xenografts (PDX) of ALL and to assess rare SVs and chromosomal aberrations, particularly hematological malignancy genes and gene fusions in different individuals detected by optical genome mapping (OGM).
 Methods: Leukemia cells from 16 patients with B-cell precursor acute lymphoblastic leukemia (B-ALL) and 6 patients with T-cell acute lymphoblastic leukemia (T-ALL) were inoculated into immuno-deficient mice, growth curves were monitored, and leukemia cells were collected after human CD45 was more than 80%. OGM (Bionano Genomics), RNA sequencing (RNA-seq) and whole genome sequencing (WGS) techniques were used to detect SVs and gene fusions. In validation, polymerase chain reaction (PCR) and fluorescence in situ hybridization (FISH) tests were performed to identify specific SVs.
 Results: On average, each model detected 42 rare SVs with known overlapping genes in different types by OGM: 12 insertions, 25 deletions, 1 inversion, 3 duplications, 2 inter-chromosomal translocations and 1 intra-chromosomal translocation. 5 rare SVs were found in multiple models (>=5), and two of them were never reported in B-ALL and T-ALL. Gene fusions were detected in all ALL models by OGM, and 17% were novel fusions. At the mRNA level, gene fusions were detected only in 19 models, and 24% of the predicted gene fusions by OGM were identical to the results of RNA-seq (high confidence results including pseudogenes). These two technologies could detect different fusion partners. For example, MLLT1 was seen at the mRNA level, and ACER1 was detected at the DNA level in the same KMT2A rearrangement model. Of the 16 B-ALL models, 6 were p190 BCR-ABL1 (a fusion of BCR exon 1 and ABL1 exon 2), 1 was p210 BCR-ABL1 (a fusion of BCR exon 13 and ABL1 exon 2) and 5 of 7 had IKZF1 gene deletions. 2 p190 BCR-ABL1 models were insensitive to imatinib and 2 p190 BCR-ABL1 models as well as the model with IKZF1 exons 4-7 deletion were sensitive to imatinib when treatment was initiated early in the disease. A novel ARL15-IKZF1 fusion was identified in one of the sensitive models. Deletion of the PRKAR2B gene was another rare SV in both models sensitive to imatinib besides the IKZF1 deletion.
 Conclusion: OGM assays were more comprehensive, and novel rare SVs were identified in ALL. Combining the results of gene fusions between different technologies will provide more accurate predictions for ALL classifications. The combination of aberrant SVs may synergize to influence the efficacy of imatinib, which warrants further investigations.
 Citation Format: Yueying Wang, Mengting Qin, JinPing Liu, Xiaobo Chen, Jia Xue, Sheng Guo. Structural variants detected by optical genome mapping in acute lymphoblastic leukemia patient-derived xenografts models [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 2053.


A representative sample of 146 diverse sesame accessions, originating from 26 countries and assigned into six groups on the basis of their eco- geographical origin, was characterized for yield and yield-contributing traits using "GGE biplot analyses". 'Which-won-where' application of GGE biplot was used to rank accessions of each group on the basis of collective trait contributions to individual accession. Eighteen promising accessions having combination of positive traits (PI 202722 Myanmar , PI 223713 India , PI 220664 Afghanistan , PI 285173 Israel , PI 165021 Turkey , PI 170711 Turkey , PI 490063 South Korea , PI 490033 South Korea , PI 345669 Soviet Union , PI 561705 Mexico , PI 594909 Mexico , PI 280790 United States , PI 198155 Egypt , PI 189081 Cameroon , PI 246386 Zaire , Pragati India , SVPR 1 India , ACHBB 97 India ) were identified. Correlation coefficient analysis (GGE biplot) as carried out over two years, revealed that total pods/plant (r=0.453**, 0.24**), pods on main shoot (r=0.337**, 0.492**) and seeds/pod (r=0.268**, 0.254**) were the main yield-contributing traits in sesame. Per cent oil content/protein content had no inverse relationship with yield which makes it possible to combine high yield and high oil content in sesame cultivars. A select group of accessions (24) were also compared for stability of performance over two years. Altogether changed ranking was observed for majority of the accessions during second year indicating their differential genonotype × environment response; however one accession PI 223713 was identified which was stable for high yield and yield contributing traits across two years.


In this paper, a new planar hexagonal shaped antenna with triple band rejections is presented. The hexagonal patch is designed on FR4-substrate, having circular cuts at its vertices and fed by $50 \Omega $ micro-strip triangular tapered feed line. This antenna with a partial ground plane and five half circular sleeves achieves a 26.15 GHz bandwidth (with return loss $\geq 10$ dB). Triple-frequency band rejections are achieved by adding an inverted E-shaped stub in addition to two triangular slots in the patch and square slot with a parasitic square inside. The proposed antenna is investigated using the high-frequency structure simulator (HFSS). The simulated scattering parameter S11 (Reflection Coefficient) results show three band rejections (1.66. – 3.29), (4.72 - 5.81) and (7.86 - 8.62) GHz to reject the unwanted interference from several applications as WiMAX and satellite communications. A small value of gain at the rejection bands with good radiation patterns in E-plane and H-plane are achieved.


In this paper we describe the underlying scientific motivation and the design of DYANA, a new neutron spectrometer dedicated to biology, biomaterials, and related soft-matter studies.


Successful release of any air to ground weapon from a combat aircraft is determined based on the positional parameters received from the sensors and the mission cues. Laser designated pod is one of the most sought weapon sensor, which gives the accurate data for Air to Ground weapon aiming. Laser designated pod being hardware intensive system, works with real world environment, it increases the development and integration effort towards finalising the weapon aiming algorithms and also pilot vehicle interface requirements. A novel method using mathematical models and the atmospheric error models is proposed to develop a high fidelity laser designated pod simulation model for functional and performance evaluation of weapon algorithms. The factors affecting the weapon trajectory computations are also considered in the sensor model outputs. The sensor model is integrated in the high fidelity flight simulator, which consists of both aircraft and Real world systems either as actual or simulated for close loop pilot evaluation. The behaviour of the sensor model is cross validated and fine-tuned with the actual sensor output and confirmed that the developed laser designated pod sensor simulation model meets all the requirement to test the air to ground weapons in the flight simulator.


The composition and structure characteristics of X80 grade pipeline steel,which was used in the 2nd West-east Gas Pipeline Project,had been researched and analyzed in this article.TEM analysis showed that,in thickness 1/4 and 1/2 of X80 grade hot rolled coil with 18.4 mm thickness,the grain boundary was purity and organization was acicular ferrite.Aiming at the toughness fluctuation of the high grade thick plate pipeline steel submerged arc welding.SEM and energy spectrum analysis had been used to analyze weld microstructure,appearance of impact fracture,composition segregation,weld inclusions,welding wire purity,etc..Approved by the research consequence,original austenite grain size has significant effect on weld toughness.And grain boundary AlN,sulfide separation are the main reasons of forming smooth brittle fracture on the welds.High melting oxide inclusions in the welds also could cause the decrease of impact value.


The development of gamma -ray imaging techniques can be traced from the pinhole camera with X-ray film recording of the image-a hopelessly insensitive technique. A major step towards improved sensitivity was to increase the absorption of incident gamma -radiation in the detector by using a suitable crystal. Detection of the emitted light quanta improved from the photographic film by way of the image intensifier until high gain photomultiplier tubes became commercially available. By about 1955 and for the next decade, the rectilinear scanner dominated the field of clinical gamma -ray imaging; this was also the period when 131I was by far the most widely used radionuclide in medicine. By 1958 Anger had already built the first gamma camera, probably five years before its time, closely followed by the positron camera. Probably the most important advance in the 1960s was not the rapid technical developments in instrumentation but a modest paper presented by Harper in 1964 on the clinical use of 99Tcm. Recently there have been technical developments in computer data reduction and processing. The dominant role of the gamma camera and 'region of interest' facilities has tended to encourage the superstition that the human body is a two-dimensional object. The increasing interest in tomographic imaging represents a return to reality, but the increased amount of information required means the use of even shorter lived radionuclides.


Finger, Hand, other objects (e.g., pens, brushes, wipers, and more specialized tools) use one such or more objects (25), hovering, selected, tapping gesture, scaling, drawing in order to provide programming and erasing, the interaction volume of the computer (7 ) And / or surface (16) (e.g., a computer screen, interactive whiteboard, horizontal interaction surface, a method of controlling and interacting video / web conferencing systems, rear projection screen, digital billboards surface, or on a TV screen) the , the system and apparatus are provided. This method, Devices and systems, optionally further either be used with all types of data projectors (3) and its fittings / stand (4) is integrated, to such a display system in an interactive flat screen used (LCD, plasma, OLED, rear projection screen, etc.) together. Apparatus, lateral position covers an interaction region (16) from a very long distance from the or from a short distance (X, Y) is determined and a further determined according to the needs of "touch" also "hovering" built fingers, hands, or other cameras to obtain the orientation of the interaction object to (1) comprising.


0. The main tasks of linguistic typology may be formulated as follows: (a) classification of natural languages according to their particular features, and (b) search for interrelations between various features of language. These interrelations may be assumed to exist not only within particular levels of language, but also between phenomena belonging to different levels (phonology, morphology, syntax, and vocabulary). However, it should be borne in mind that typological investigation is centred around morphology. The reasons for the special suitability of morphology for typological investigations have been discussed by V. Skalioka. Unfortunately, his stimulating ideas have been published mainly in Czech. On the basis of the mutual relations between the individual linguistic phenomena a new type of classification of languages can be drafted which takes into account not only the absolute magnitude of the individual typological features, but also their relations to each other. Such a classification may be called RELATIONAL. Relations of the typological features may be best ascertained if the magnitude of the individual features is expressed numerically. The first attempt along these lines was undertaken by J. H. Greenberg, who proposed a procedure which makes it possible to evaluate quantitatively (= to measure) some grammatical features of language by means of universally defined grammatical phenomena. The magnitudes of various grammatical features are expressed quantitatively by a set of indices.


IN OPHTHALMOLOGIC and otolaryngologic surgery one encounters some of the most difficult procedures in anesthesia. This is particularly true if the requirements of the patient, the surgeon, and the anesthesiologist are to be satisfied. Regional analgesia may be employed satisfactorily for short superficial procedures, since the patient will usually tolerate an uncomfortable position as well as manipulation discomforts for limited periods. However, during long and/or tedious procedures requiring deep manipulations of the face, nasal pharynx, oral pharynx, pharynx, larynx, or trachea, the constant cooperation of the patient must not be relied on. Restlessness and motion at a crucial point by a patient who was thought to be cooperative may prove disastrous to the patient or to the operative result being sought. Likewise, the administration of an intravenous, rectal, or inhalation anesthetic to a patient in whom regional analgesia was started and whose airway has been made inaccessible by the drapes


Independent component analysis (ICA) attempts to extract from observed multivariate data independent components (also called factors or latent variables) that are as statistically independent from each other as possible. You can use ICA to reveal the hidden structure of the data in applications in many different fields, such as audio processing, biomedical signal processing, and image processing. This paper briefly covers the underlying principles of ICA and then discusses how to use the ICA procedure, available in SAS® Visual Statistics 8.3 in SAS® Viya®, to perform independent component analysis.


The catalytic hydrogenation of 2-ethylanthraquinone in the anthraquinone process of production of hydrogen peroxide gain-ing more interest to meet environmental demands of hydrogen peroxide as green oxidant. Noble metal palladium becomes a new category of catalyst due to their significant applicability in the catalytic hydrogenation reactions. Herein, wet impregnation method was used for synthesis of palladium supported on hollow ceramic microsphere catalysts. The palladium supported on hollow ceramic microsphere exhibits high catalytic selectivity, activity and stability in the liquid phase hydrogenation of 2-ethylanthraquinone. The reaction obeyed zero and first order kinetics with 2-ethylanthraquinone and hydrogen respectively. The average value of reaction rate constant observed was 2 mol L –1 h –1 and 6 L h –1 respectively. Highest yield of hydrogen peroxide obtained was 96.5% with a less consumption of 2-ethylanthraquinone.


Abstract The problem of designing an output feedback compensator for any biased sinusoidal disturbance is considered. In this paper, we will develop the approach presented in (Marino et al. , 2003). In (Marino et al. , 2003) a compensator of order (2 n +6) is proposed, which solves the posed problem by using the adaptive observers developed in (Marino and Tomei, 1995; Marino et al. , 2001). This problem is solved by a ( n + 4)-order compensator.


has openings on the Persian Empire, Alexander and the Greeks, Egypt and the Seleucids, as well as the history of the Jews under their governance, and the bid for independence by the Maccabees, and the establishment of a monarchical state. The third section is divided into two segments, Palestine under Roman rule and then the Christian Era. In the first, Roman Palestine is placed within the context of Rome in the East. Due importance is given to the Nabataean kingdom, the development of the synagogue, and to the Dead Sea Scrolls and the Essene community. In the two openings devoted to Herod the Great one would have thought it would have been opportune to have given a genealogy of this family, confusing by reason of intermarriage as well as by a narrow choice of names. The second segment, the Christian Era, opens with Galilee in the first century A.D. At the bottom of p. 162 is a retouched version of the synagogue at Capernaum which is certainly of the fourth century, and possibly of the fifth. The first century synagogue lies below it, as is now made clear, in the Liber Annuus of the Franciscan Studium Biblicum, but so far we have only what constitute no more than annual reports and a splendidly illustrated tourist guide published by Fr Stanislao Loffreda, OFM in 1985. The "apparently" of the present text is hardly justified. The map on p. 163 and the accompanying text have a real howler. Both it and p. 165 show Chorazin, but the text on p. 163 says it is "now no longer to be identified." The editor really must make up his mind. The opening on "Jesus's Last Days" is devoted largely to the trial and the crucifixion. There is no mention of the last discourses which, traditionally, are associated with the site of the Eleona church on the Mount of Olives, nor of the excavation of the hill of Calvary by Fr Florentino Diez Fernandes, OSA, which uncovered a pagan altar on it of the time of Hadrian, thus authenticating St Jerome's identification of the site and Hadrian's desecration of it. Pending Fr Diez's eagerly awaited book, he has given a preliminary account in Le Monde de la Bible, no. 33,1984. The story of the beginnings of Christianity is then carried forward by openings on St Paul, on the Jewish diaspora, and the Jewish revolts of 67-70 and 132-5. Finally we pass to Byzantine Palestine. The opportunity to present a map of Palestine based on Eusebius's Onomasticon has unfortunately been missed, for it shows what slender roots Christianity had achieved there before the time of Constantine, and its co-existence with cities and settlements which were wholly Jewish, and others that were pagan. Missed too is any proper description of the Roman road system, Rome's greatest gift to Palestine, and likewise described by Eusebius.


In recent years various Puerto Rican cultural studies have exposed the paternalism and classism that lie behind the island's hegemonic nationalist discourse since the 1930s. They have also exposed the fundamental role of the essay form in this canonic discourse. These studies read Puerto Rican literature as if it were an autonomous discursive field. Few critics have pointed to the similar literary products published in different parts of Latin America—a similarity made striking given the still difficult communications among intellectuals in the region. Among the works occasionally compared are those produced beginning in the 1960s by the Mexicans Elena Poniatowska and Carlos Monsivais and those published in the 1970s by a group of Puerto Rican writers referred to as the los francotiradores, "the gunmen"—an allusion to their well‐evidenced ambition to "murder" the national myths created by their putative fathers two generations before. Edgardo Rodriguez Julia and Ana Lydia Vega are among these writers.


Smart city is considered to be the trend of future development of city. The development of the archives informatization created new opportunities for development of the archives. In this paper, on the basis of simple introduction of smart city, analyzing the influence on archives informatization from smart city, compared to the digital archives,pointing out the innovation of archives under the environment of smart city. Finally, an elaboration to archives information management of archives under the background of smart city.


The incidence of bacterial pneumonia is increased in alcoholic patients. Alcohol consumption has been shown to impair cytokine production. Tumor necrosis factor alpha (TNF‐α) and interferon gamma (IFN‐γ) are critical for host defense against Klebsiella pneumoniae (K. pneumoniae). In order to examine the influence of alcohol on the immune response to infection, we investigated the frequency of TNF‐α and IFN‐γ produced by splenic T‐lymphocytes in a murine model of gram‐negative pneumonia initiated after 8 days of alcohol treatment. Thirty‐two Balb/c mice were pretreated with ethanol (3 mg/g body weight) or saline intraperitoneally over 8 days. On day 7 half of each group was administered K. pneumoniae. Mice were sacrificed 24 hours later to excise lungs and liver for histological assessment and spleens for cell isolation. IFN‐γ‐ and TNF‐α‐producing CD4+ and CD8+ lymphocytes were determined by FACS analysis. In mice with Klebsiella infection, the percentages of IFN‐γ‐producing CD4+ (P < 0.01) and CD8+ (P < 0.01) were significantly decreased, the percentages of TNF‐α‐producing CD4+ (P = 0.01) and CD8+ (P < 0.01) T cells were significantly elevated after alcohol treatment compared with mice with saline treatment. The histological assessment showed an aggravation of K. pneumoniae‐induced pneumonia in alcohol‐treated mice. Alcohol differentially affects IFN‐γ and TNF‐α production in Klebsiella‐infected mice. Both effects obviously led to a weakened immune response as seen by increased histological damage. This suggests a role of T cells in the increased susceptibility of the alcoholic host to nosocomial infection due to inadequate cytokine response.


Italy, fifty years ago, passed a bunch of bills which overhauled its tax system. Thereafter, the old taxes, which had survived for about a century, were replaced by a set of 'modern' ones. The process was prompted by a law of delegation, which laid down the cornerstones of the tax reform to come: its principles – such as personality, progressivity, differentiation, simplification, and so on – were meant to steer the Country towards a new era of social justice and economic development. Things, regrettably, went otherwise.


Abstract It is commonly thought that predators use olfactory cues to find turtle nests and that these cues are diminished by rainfall. We studied the relationship between rainfall on the date of oviposition and depredation of nests of the Painted Turtle, Chrysemys picta, on a major nesting beach between 1996 and 2003. We analyzed two scenarios: rainfall versus no rainfall on the date of oviposition; and no rainfall versus intense or weak rainfall on the date of oviposition. For the first scenario, we found no consistent association between rainfall and nest depredation before hatching. In 1996, rainfall on the date of oviposition appeared to increase the chance of nest depredation; in 2000, it appeared to decrease the chance of nest depredation; and there was no statistically significant relationship in the remaining years or overall. In the second analysis, the relative amount of rain was associated with nest depredation before hatching. Nests constructed on days with a larger amount of rain were less likely to be depredated than nests constructed on days with no rain or smaller amounts of rain. Nests constructed on days with smaller amounts of rain were more likely to be depredated than nests constructed on days with no rain.


SARS spatio-temporal transmission and control model is established,and multi-agent technology is employed to model the SARS spatio-temporal spreading behavior.Based on the virtual geographic environment platform and applyication of Java and VRML tools,this paper designs and develops a prototype system to carry out agent-based simulation of SARS transmission and control in a virtual community.The rudimentary experimental results demonstrate that the model and simulation implemented in the paper can be used to represent the characteristics and laws of SARS transmission.


Severe climatic and environmental changes are far more prevalent in Earth history than major extinction events, and the relationship between environmental change and extinction severity has important implications for the outcome of the ongoing anthropogenic extinction event. The response of mineralized marine plankton to environmental change offers an interesting contrast to the overall record of marine biota, which is dominated by benthic invertebrates. Here, we summarize changes in the species diversity of planktic foraminifera and calcareous nannoplankton over the Mesozoic-Cenozoic and that of radiolarians and diatoms over the Cenozoic. We find that, aside from the Triassic-Jurassic and Cretaceous-Paleogene mass extinction events, extinction in the plankton is decoupled from that in the benthos. Extinction in the plankton appears to be driven primarily by major climatic shifts affecting water column stratification, temperature, and, perhaps, chemistry. Changes that strongly affect the benthos, like acidification and anoxia, have little effect on the plankton, or are associated with radiation.


Harvesting of the radial artery has become a common surgical procedure. Variations in the radial artery may affect its origin or its course. Variations in the course are rare and classified in 2 classes (1& 2) according to the tendons forming the anatomical snuff box or radial fossa of the hand. In a study of seventy randomly selected cadavers assigned to medical students for dissection, an atypical case of class 2 was found and is described here.


the tail, the facial muscles, and the muscles of the jaws and tongue. These are all situated in the anterior parts of the brain in advance of the fissure of Sylvius, and the individual centres are marked off in the various external convolutions, of which woodcuts are given. The general plan is, that in the superior external convolution, anterior and posterior to the crucial sulcus, the various movements of the paws, legs, and tail are centralised, and it is shown that the differentiation of these centres is to a great extent characteristic of the animal's habits ; the centre from the fore-paw in cats being much more highly differentiated than in dogs and rabbits. The middle external convolution governs the movements of the eyelids, face, and eyes, while the inferior and the Sylvian govern various movements of the whiskers, angle of the mouth, depressors of the lower jaw, and tongue. In the convolutions posterior to the fissure of Sylvius, certain movements are described as resulting from irritation, viz. of the ears, eyes, etc. In the paper as yet published no attempt is made to explain the signification of these; but the author, from his later experiments, indicated at the Meeting of the British Association that he had been able to obtain indications of the situation in these regions of the centres of special sense, sight, hearing, and smell. These results and conclusions, are however not as yet detailed fully. The author indicates, in a note in the paper published in the West Riding Reports, that he had at that time explored the brain of the monkey, and satisfactorily localised the regions and the homologues ofthe centresalreadydiscovered in the brains of the cat, rabbit, and dog. One of the more important conclusions drawn from the experiments is, that the region which governs the movements of the mouth and tongue in cats and dogs is the homologue of what is known as Broca's convolution in man, viz. the posterior part of the inferior frontal. This, it may be stated, is further borne out by experiments on monkeys. The pathology of Aphasia is thus rendered comparatively simple. The memory of words is situated in that part of the brain which governs the movements of articulation. It is shown, however, by the experiments, that the brain is symmetrical, and that the corresponding part of each hemisphere produces exactly the same effect on opposite sides of the body. Generally the action is unilateral and crossed, but as regards the mouth the action is almost bilateral, and hence disease of one or other side alone does not cause paralysis of the articulating muscles, because the other side is able to govern as before. The occurrence of loss of speech with lesion of the left side is attributed to the fact that most people are left-brained, and that therefore a lesion of the left side causes such an interference with the voluntary recalling of words that the person is speechless, not because memory of words is utterly lost, as this exists in the undamaged side, but because he is unable to lay hold of the word which he wishes to express. With the education of the other side, however, the individual recovers the power of speech. During the interval of recovery of speech only automatic expressions or interjections are uttered, which are evoked by a sort of reflex action, and unconnected with volition. Among other points discussed is the hypothesis advanced by Dr. Broadbent, that associated movements of the body are bilaterally co-ordinated in each hemisphere. The author thinks the experiments which he gives indicate not an anatomical but a physiological coordination through the media of the lower ganglia. The results of the experiments in the corpora striata, optic thalami, corpora quadrigemina, and cerebellum, are also detailed. The corpora striata are shown to be motor in function, and to govern all the muscles of the opposite side ; representing all the muscles directed by the hemispheres, and having a physiological subordination to these as higher centres. The optic thalami are shown to have no motor function, and the author attributes the interference with motion, which is sometimes described in connection with disease of these ganglia, to affection of the motor strands with which they are in close relation. The corpora quadrigemina have a special relation to the eyes and also to the extensor muscles. Irritation of the nates causes great dilatation of the pupils. The action is crossed, but powerful irritation easily acts on both sides of the body. Trismus and opisthotonus are induced when these ganglia are powerfully stimulated. The cerebellum is shown to have a function, which has never been allotted to it, viz. to be a co-ordinating centre for the muscles of the eyeballs. The author has only given the results of his experiments on the cerebellum of rabbits, but he has since extended and confirmed them in cats, dogs, and monkeys. The various lobules of the rabbit's cerebellum are shown to have the power of directing the eyes in certain definite directions. These cerebellar oculo-motorial centres are brought into relation with the cerebellum as a coordinating centre for the muscles concerned in the maintenance of the equilibrium, and these functions are indicated as mutually depending on each other. A more complete exposition of the facts of experiment, and an account of the results obtained from a further investigation of the brains of the various classes of the Vertebrata, is in process of pub. lication.


The utility model discloses a tea screening device, which comprises a case, a screening device, a feed hopper and discharge ports, wherein the screening device is arranged in the case, the feed hopper and the discharge ports are arranged on the case, the screening device comprises a motor, an eccentric wheel mechanism and a plurality of layers of vibration screens, the vibration screens are obliquely arranged, the vibration screens are connected with the motor through the eccentric wheel mechanism, screen holes of the vibration screens are arranged from top to bottom and are reduced gradually, the discharge ports which are corresponding to different layers of vibration screens are arranged on the case, and the feed hopper is arranged on the top portion of the case. The tea screening device is provided with a plurality of layers of vibration screens, can repeatedly screen tea in multiple stages, and is excellent in screening effect, simple in driving mechanism and low in making cost.


In this present work, a system of two aqueous phases (ATPS) composed of polyethylene glycol 4000, K2HPO4 and NaCl was used for extraction of xylanase produced by Jonesia denitrificans BN13. Changes in the parameters of the system such as: the concentration of PEG and the NaCl, and pH of system, and the partitioning of xylanase was studied. The production of xylanases in a medieum containg birchwood xylan was 0,51U/ml, the xylanase has a specificity against oat spelt xylan . The best ATPS for the extraction of the xynalase jonesia Denitrifican was a system composed of PEG 4000 12%, K2HP04 14%, NaCl 1,63% and pH 6, the partition coefficient and the yield were : 133,33, 98,01% respectively. Key-words: Jonesia denitrificans BN 13, Xylanase, Oat spelt xylan, ATPS, Extraction.


Introduction: Patients with repaired TOF have increased arrhythmia risk due to myocardial fibrosis, scar and right ventricular dilation. Current risk stratification lacks consistent predictive valu...


1) The fatty acid composition (16:0, 18:0, 18:1, 18:2, 20:4 in wt%) of platelet total lipids and platelet aggregation (PAG) in citrated PRP induced by ADP (1 and 0.1mM) were studied in 20 normal subjects. PAG was expressed as percent aggregation measured by light transmission method following aggregation to ADP such as maximum, at 1min. and 3min. after the addition of ADP. The results of Student's t test of the correlation coefficients between PAG and individual fatty acid concentration (wt%) revealed that only those of linoleic acid (18:2) were significant (0.05<p<0.1).2) The effect of ADP-induced aggregation on the platelet fatty acid composition was studied as follows. PRP was divided into two parts and usual ADP aggregation (1mM) was done on the one PRP and the other PRP was treated in the same manner with the addition of saline in place of ADP. The platelets obtained from the two PRP were then analyzed in the same manner so as to compare the fatty acid composition of platelet total lipids under the two conditions. The correlation coefficients between the difference in individual fatty acid concentration under the two conditions and the concentration of the fatty acid without the addition of ADP were significant in 18:0 and 18:1 (p<0.01) and in 18:2 and 20:4 (p<0.05). From the results it was concluded that fatty acid composition of platelet converged to a certain level when it was aggregated by the addition of ADP. The same trends were observed following aggregation to epinephrine or collagen.


When administered properly, performance appraisals may lead to increased job satisfaction and decreased absenteeism and turnover rate; situations desired by the foodservice industry. The purposes of this study were to determine the relationship between frequency of performance appraisal and employees' absenteeism and turnover rate and to investigate the managers' attitudes toward appraisals. Respondents were from Missouri schools, long-term care (LTC) facilities and hospitals (n = 214, 231 and 107, respectively). Absenteeism was lower in facilities where performance appraisals were conducted at least once a year, schools and LTC than in hospitals where appraisals were conducted less frequently (p<.05). However, no significant difference in turnover rate was noted among facilities regardless of the frequency of the evaluations. Most respondents had a mildly positive attitude toward performance appraisals (4.74 on a 7 point scale), agreed that appraisals were useful (6.19) and that employees performed better after an evaluation (5.04). Overall, respondents' attitude scores were significantly higher if evaluations were performed to determine wages, and to analyze strengths and weaknesses of employees, rather than if they were required by administration. These data confirm the usefulness of performance appraisals in lowering absenteeism of foodservice employees.


The paper presents a formulation developed to produce cement compound based on a mockup evaporation residue and a genuine evaporation residue from the Novovoronezh NPP with a VVER-type reactor unit given a salt content of 25 to 33 wt.%. The study experimentally confirms that the quality indicators of the resulting compound comply with NP-019-15 requirements.


Magnetic resonance imaging is useful for the diagnosis of desmopathy of the proximal aspect of the suspensory ligament. Nuclear scintigraphy is effective at identifying regions of pathology but is less sensitive at identifying a specific cause of that pathology. Authors' addresses: Alamo Pintado Equine Medical Center, PO Box 249, 2501 Santa Barbara Avenue, Los Olivos, CA 93441 (Zdimal, Judy, Herthel); and College of Veterinary Medicine, University of Minnesota, 1365 Gortner Avenue, St. Paul, MN 55108 (Saveraid); e-mail: firstname.lastname@example.com. *Corresponding and presenting author. © 2012 AAEP.


This paper is concerned with the following Schrodinger equation: $$ \left\{ \begin{array}{ll} -\triangle u+V(x)u=f(x, u), \ \   \ x\in\mathbb R^N,\\ u(x)\rightarrow0 \ \ \ \ \ \ \ \ \ \ \ \ \ \ \ \ as \ \ \  \ |x| \rightarrow\infty, \end{array} \right. $$ where the potential $V$ and $f$ are periodic with respect to $x$ and $0$ is a boundary point of the spectrum $\sigma(-\triangle+V)$. By a generalized variant fountain theorem and an approximation technique, for old $f$, we are able to obtain the existence of infinitely many large energy solutions.


Stand-alone software for predicting contaminant transport and behaviour is well developed, but to be more effective, it needs to be integrated within whole building simulation. This paper describes implementation of such a model within whole building dynamic simulation. The model is further enhanced by allowing specification of filter efficiencies, source/sink models, first order chemical reactions, contaminant based control and scheduled ambient concentration profiling. The model was validated against analytical solutions and for complex cases against CONTAM and COMIS. Empirical validation was carried out using information from IEA Task 23. The paper concludes with a case study illustrating the impact of including dynamic thermal and wind pressure conditions on predicted contaminant concentrations and flows.


In recent years, blockchain technology has increasingly attracted attention in the field of civil aviation, whose features such as decentralization, openness, transparency, traceability, and anonymity provide new ideas for solving problems in civil aviation. In this paper, from the perspective of the alliance chain, we design and analyze the application of blockchain technology in six scenarios, including passenger identity racking, baggage handling and indemnity, ticket selling, aircraft maintenance record, passenger privacy and security, and opaque examination and approval of airline resources.


Electronic commerce logistics management information system is a network of people and computers, such as the information of the logistics related information collection, transmission, storage, processing, maintenance and use of the system. E-commerce logistics distribution is refers to enterprise logistics distribution using networked computer technology and modern hardware, software system and the advanced management method. The paper presents application of semantic mining technology in building intelligent logistics system of electronic commerce.


Human alpha defensins (Human neutrophil peptides 1-3, HNP1-3) are constitutively produced by immunocompetent cells and protect against pathogenic bacteria. The effect of low molecular weight bioregulators catecholamine norepinephrine and muramyl peptide on the expression of HNP1-3 was studied. It has been shown that muramylpeptide restores the level of alpha-defensins HNP1-3 produced by human neutrophils in vitro, reduced by the action of catecholamine norepinephrine.


Contents Acknowledgments Methodological Preface I: Introductory 1: Introduction: An Inquiry into Forms of Life II. Paradoxico-Criticism 2: Origins of Paradoxico-Criticism: Structuralism and Analytic Philosophy 3: Deleuze, Plato, and the Paradoxes of Sense 4: Derrida and Formalism: Formalizing the Undecidable 5: Wittgenstein and Parmenides 6: Wittgenstein and Turing III: Badiou and the Stakes of Formalism 7: Formalism and Force: The Many Worlds of Badiou 8: Badiou vs. Paradoxico-Criticism 9: Paradoxico: Critique of Badiou 10: The Politics of Logic: Critical and Practical Consequences Notes Bibliography Index


The purpose of this study was to predict marital satisfaction of couples in Isfahan based on empathy and forgiveness. Of all the couples in Isfahan in 2011-2012, 100 couples were sampled through random cluster sampling. Our research tools included Enriching Marital Satisfaction Scale (1993), Emotional Empathy Scale (1972), and Family Forgiveness Scale (1998). Data analyzed with Pearson correlation and linear regression. Results showed that empathy and emotional forgiveness can predict cognitive satisfaction of couples (P<0.01). Also the couples' ages could predict marital satisfaction. (P<0.05).


Research on benefits for reducing surface runoff and sediment by different layers of grass vegetation is important to assess the role for grass vegettaion controlling soil erosion.The simulated rainfall experiment is used to quantify benefits for reducing surface runoff and sediment by different layers of grass vegetation.The research results show that grass vegetation,like forest and bush,can effectively control soil erosion.When surface cover of natural grassland reaches 90%,the benefits for grass reducing surface runoff is above 90% and not any erosion occurs.The layers of canopy and litter grassland reduce runoff and sediment yield by 23.7% and by 44.6%,separately.The ground layer of soil body with dense root system reduces runoff and sediment yield by 72.5% and 55.4%,separately.


This diploma work deals with creation of intra-plant accounting guidelines for the company AUTOKOM, Ltd., which the company is going to follow. The starting point were some already unsuitable guidelines, but most of the guidelines have not been elaborated by the company at all. In the first part of the diploma work, there is a description of theoretical presumptions of the intra-plant accounting guidelines. In the second part, there is an analysis of a real state of guidelines and a proposal of new guidelines. In the last part of the diploma work, there are the individual guidelines elaborated according to valid law, regulations, rules and accounting standards.


The study is chosen to dispel doubts about guidance and ignorance in the minds of Muslims and to light the candle of awareness. Because in the present era, people with a secular mindset are confusing the innocent people in this debate and inviting them to abhor religion. In this research, an effort has been made to convey the truth to the people in the light of the Holy Quran and the Sunnah of the Prophet Muhammad (PBUH). There is no doubt that Allah is supreme. He does what He wants. He has the power to create results without possibilities. He is free from all types of reasons and causes of any work. This materialistic universe moves under the rules and regulations farmed by Allah. Allah does everything with His knowledge, power, and reason. But there are some rules and codes to understand this issue, which has been discussed below in detail.


The conference planning system CPS has been originally developed to facilitate the task of the program chairman in preparing a large international scientific conference. Finally it came out that this CPS system has a couple of quite general characteristics which makes it applicable as an instrument for similar planning purposes. This paper describes first the general duties during the planning phase and the final set-up of the scientific program of a large international conference. It further enlightens the logical structure of the system and explains a few of the implementational details. Finally some remarks are made concerning the experience in using this system and additional conclusions for further applications are drawn.


Summary. A collaboration between teachers and parents was organised so that every child in two randomly chosen top infant classes at two schools (one class at each school), randomly allocated from six multiracial inner-city schools, was regularly heard reading at home from books sent by the class teacher. The intervention was continued for two years, i.e., until the end of the first year in the junior school. Comparison was made with the parallel classes at the same schools, and with randomly chosen classes at two schools, again randomly allocated, where children were given extra reading tuition in school. This report presents cross-sectional analyses which show a highly significant improvement by children who received extra practice at home in comparison with control groups, but no comparable improvement by children who received extra help at school. The gains were made consistently by children of all ability levels.


Objective To investigate the effect of Lycium barbarum polysaccharides( LBP) on expression of nerve growth factor ( NGF) after sciatic nerve mutilation in rats. Methods 72 female SD rats were randomly divided into three groups: Control group, Model group and Lycium Barbarum Polysaccharides( LBP) group,Model group and LBP group were wipe off 2cm right sciatic nerve,LBP group were intraperitoneal injected LBP 10mg/( kg.d) ,Model group were given physiological saline,Control group were treated without any treatment. Six rats were choosed randomly and the near-heart never of sciatic nerve and conjoint dorsal root ganglia and spinal cord were obtained on the7th,14th,21st and 28th day; Immunohistochemistry and Image-pro plus 6. 0 were used to evaluate the expression of NGF. Results The expression of NGF positive area and Average optical density in Control group are obviously lower than the other group. The NGF Average optical density in sciatic nerve,dorsal root ganglia and spinal Cord in LBP group are obviously lower than that in Model group on the 7th,14th,21st,28th day( P0. 05) . Conclusion LBP can inhibition the expression of NGF the related nerve ganglion and spinal cord after sciatic nerve divided in rats. expression of NGF owned in sciatic nerve and its related nerve ganglion and spinal cord after sciatic nerve dividing in rats.


Four-switch buck-boost converter (FSBB) has received extensive attention in the fields of power battery test and energy storage because of its bidirectional buck and boost capabilities, which are suitable for wide-range voltage changes. However, due to its complex mode detection and disturbance brought by mode transition, it faces great challenge of operating mode selection and also has difficulty in achieving smooth mode transition. In this paper, a mode selection and transition strategy based on predictive control strategy is proposed, and the traditional three modes of FSBB are expanded to four modes, which reduces the sudden change of duty cycle resulted from control dead zones. The predictive control method is used to select the best working mode and ensure smooth transition of working mode. The simulation results demonstrate that the proposed method can successfully accomplish the aforementioned functions and exhibit strong dynamic performance when the input voltage and output are almost equal.


Focusing on the case of the European Union's Sixth Framework Programme and drawing on a range of documentary material from the European Commission, Council of Ministers, Parliament and numerous committees, this paper analyses the cultural politics surrounding the debate about the funding of human embryonic stem cell science. First, it places HESC science within the context of the global struggle over the moral status of the human embryo and a conceptual understanding of the cultural politics produced by that struggle. Secondly, it outlines the primary components of cultural trading in HESC science, constructs a framework for the analysis of the EU's moral economy in this policy field and, using the same components, outlines a policy profile of the regulatory positions of the then 15 Member States as a context for the FP6 debates. Thirdly, it applies this framework to the cultural conflict surrounding FP6 and HESC science, the institutional manoeuvring that accompanied and to an extent channelled that conflict, and the contribution of bioethics to the operation of the EU's growing, if inefficient, moral economy in this field.


Intravenous adenosine is being used for the treatment of paroxysmal supraventricular tachycardia and paroxysmal junctional tachyarrhythmia in nonpregnant patients. In the cases presented here, intravenous adenosine rapidly terminated maternal paroxysmal supraventricular tachycardia in pregnant patients without maternal or fetal complications. Its potential advantages over other antiarrhythmics are discussed.


XML was applied to web-Based application system for efficient data supervision and processing. Also, ASP permitted embodiment of easy web-Based programming, and UML is studied by the new alternative of system modelling techniques. Thus, In this paper see embodied student taking a course application management system using XML, ASP, UML. This was composed, and used XML for effective data supervision and processing by student mode and administrator mode. Also, It used UML for systems analysis and design, and whole system implemented by ASP. And, Database implemented to used in MS-ACCESS, and it used java Script language for efficient practical use of web document.


In this paper, the author combines net resources with English teaching and explores the possibility of English teaching with the aid of net resources,as well as its advantages and the requirements for English teachers.


(I) a carrier material consisting essentially of crystalline matrix material, for example a in the delivery system in the form of a solid dispersion comprising erythritol or mannitol and (ii) Structure :( Compound I) or a solid active ingredient having their salts Te, the delivery system the solid active ingredient (ii) is dispersed in a matrix of the carrier material (i).


The Heat shock protein-70 (Hsp70) gene family is one of the protective mechanisms; however, it has not been widely studied in tomatoes. Therefore, the current study provides the first report genome-wide analysis of the Hsp70 gene family in tomato (Solanum lycopersicum L.) under five heavy metals (Cd2+, Co2+, Mn2+, Zn2+, and Fe2+) stresses. We identified 23 candidate genes of the Hsp70 gene family based on the PF00012 domain through bioinformatics studies, including gene structure, distribution, synteny, phylogenetic tree, protein-protein interactions, gene ontology, and previous RNA-seq data analysis followed by qRT-PCR analysis. Based on the phylogenetic analysis, the 23 candidate genes were classified into five subfamilies where the same subfamily contains similar SlHsp70 proteins. Many pairs of SlHsp70 gene duplications have appeared, consisting of tandem and segment duplication. In addition, analysis of previous RNA-seq besides the gene ontology gave us significant evidence about the vital roles of these genes during tomato development and growth. The SlHsp7s showed different responses, which were varied depend on different plant tissues and types of heavy metal. Some of the SlHsp70s were up-regulated after heavy metal exposure, such as Cd2+/SlHsp70-23 and Mn2+/ SlHsp70-8. Still, down-regulated others such as Fe2+/ SlHsp70-18. Finally, our gene expression analysis revealed the significant roles of the Hsp70s, especially, SlHsp70- 3, SlHsp70-8, SlHsp70-12, SlHsp70-19, and SlHsp70-23, with the different heavy metals treatments.


Parkinson's disease (PD) is a common degenerative disease of the nervous system. The pathogenesis of PD is not yet clear. However, it has been reported that many factors including age, environmental factors, and genetic factors are included. Rotenone is one of the naturally occurring insecticides found in many plants of the Derris, Lonchocarpus, Tephrosia and Mundulea species. It is also one of the classic neurotoxic drugs to produce PD models. Ndfip1 has been reported to be a neuroprotective protein in the brain. Therefore, in this study, we examined the expression of Ndfip1 in the mitochondrial complex I inhibitor rotenone-induced PD models in MES23.5 dopaminergic cells. Our results showed that rotenone has a concentration-dependent and time-dependent impairment effect on MES23.5 cells. When the concentration of rotenone was 25 nmol/L, the viability of the cells was significantly decreased at 24 hrs. Further study showed that the expression of Ndfip1 increased in the mRNA levels at 6 hrs after 25 nmol/L rotenone treatment. The protein levels of Ndfip1 increased at 3 hrs, 6 hrs and decreased at 12 hrs after 100 nmol/L rotenone treatment. This indicates that rotenone caused damage to MES23.5 dopaminergic cells, which is accompanied by a decrease of Ndfip1.


Soft and hard walls are realized for a circular waveguide with walls coated by a uniform dielectric layer of appropriate thickness and loaded with conducting strips. The strips are oriented along the waveguide axis (z‐axis) for hard surfaces or φ‐directed for soft surfaces in a periodic form. The simple approximate asymptotic strip boundary condition (ASBC) is used to analyze the structure. For the dominant mode, when the waveguide walls are hard or soft, a linear field distribution across the waveguide cross section can be obtained. Then the waveguide can be used as an antenna with good linear polarization. The characteristics of such waveguides are presented with sample radiation patterns as compared with hollow waveguide radiation patterns. © 2001 John Wiley & Sons, Inc. Microwave Opt Technol Lett 29: 433–436, 2001.


The coordination compounds of general formula [M{X}2(2-propanol)]2 (M = Co(II) (1), Ni(II) (2); {X} = Cl3CC(O)NP(O)(OCH3)2) have been prepared and characterized by means of IR, UV-VIS spectroscopy and X-ray analysis. The compounds are isomorphous according to X-ray powder diffraction studies. Crystal data for 1: triclinic, P1̄, with a = 9.510(2), b = 12.053(2), c = 23.594(5) Å ,a = 84.74(3), b = 86.47(3), g = 75.45(3)°, Z = 2, V = 2604.7(9) Å3, R1 = 0.067, wR2 = 0.143 for 6299 unique reflection used). The complex adopts a dimeric centrosymmetric molecular array with Co-O-Co bridges formed via the oxygen atoms of phosphoryl groups. This structure is stabilized by intradimeric hydrogen bonds of the type P = O---H with the coordinated 2-propanol. The metal atoms are coordinated in slightly distorted octahedra (Co-O 2.050(5)-2.140(5) Å). Unlike the β-diketonate compounds of similar structure, the dimeric complexes are stable towards donor species and in 2-propanol solution.


: Fluoroaromatic scaffolds pose a challenge to lithiation due to low stability of lithiated intermediates. Here we apply trans-metal-trapping (TMT) to a series of key fluorinated aromatics. In TMT, LiTMP performs the metalation, while an organometallic trap intercepts the emergent carbanion. This study contrasts the trapping abilities of iBu 2 AlTMP and Ga(CH 2 SiMe 3 ) 3 , structurally mapping their TMT reactions and probing relative stabilities of metalated fluoroaromatic intermediates by NMR studies. Results show the installed Al @ C(aryl) bonds are more prone to decomposition by benzyne formation and Li-F liberation, than the Ga @ C(aryl) species. The latter are thus better for onward reactivity as demonstrated in cross-coupling reactions with benzoyl chloride that produce ketones. TMT the of molecular forms of inorganic salts, unravelled key complex decomposition pathways involved in metalation of fluoroarenes, and established the greater robustness of arylgallium intermediates versus arylaluminum species thus opening potential new synthetic uses for the heavier group 13 metal.


The effect of γ-irradiation on the degradation of p-GaP-n-GaP red light emitting diodes (LED's) is studied. It is shown that after the irradiation to a dose of 1.5 × 1017 γ/cm2 the LED's degrade, a decrease of red electroluminescence maximum (λ = 0.675 μm, T = 77 K) by a factor of about 3 to 6 is observed. A following isochronal annealing of the irradiated diodes over the temperature interval from 100 to 300 °C leads to a partial recovery of the starting luminescence properties of the diodes. Similar effect is also observed when forward currents flow through the diode (j = 10−1 to 10−2 A/cm2) at temperatures 77 and 300 K. The data obtained are explained by defects (Frenkel type) which act as non-radiative centres.

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This paper introduces the content of cognitive flexiblity theory and its viewpoint about teaching and learning. Basing on College English Curriculum Requirement and TBL model, the author tries to explore the web-based College English TBL teaching model. Applying cognitive flexibility theory to this new model is an effective way to promote the College English Teaching Reform.


Studies of gubernatorial elections have found vote choice to be a function of party identification, assessments of economic conditions, and the president's job performance but have not tested for a referendum effect concerning the incumbent governor. This analysis uses state polling data to demonstrate that voters with favorable images of the incumbent governor have a higher probability of voting for the candidate of the incumbent's party. The effect is greater when the incumbent seeks reelection, but it is present in open contests as well.


PURPOSE: An in-situ physical vapor deposition system is provided to perform an in-situ deposition for both faces of a substrate by using a fixed physical vapor deposition source. CONSTITUTION: An in-situ physical vapor deposition system comprises a physical vapor deposition source(3), a vacuum chamber(1), a vacuum pump(2), and a substrate rotator(4). The substrate rotator comprises a rotating plate(9,10), a rotation gear(11), and a fixed gear(12). The rotating plate comprises two or more than two substrate holders to revolve and rotate the substrate holder. The rotating gear is installed to each rotating plate. The fixed gear is fixed to the vacuum chamber or an arbitrary portion to be connected to the rotation gear.


Only a few studies have used objective measurements to investigate the relationship between sleep quality and obesity. These studies showed controversial results.


Engineering pedagogy is a professional activity that forms and develops the required future engineers' competences with the help of appropriate pedagogical tools and technologies. It is essential that engineering graduates were productive, ready to actively participate in the innovative development of the chosen sphere. Ongoing development of engineering activity, its modernization, improvement, expansion into other areas of activity requires adjustment, updating goals, means and methodology of educational activity in general and engineering pedagogy in particular. Today engineering pedagogy should focus on the issues of a new ontology of engineering activity. The article aims to clarify ontological and methodological foundations of engineering activity, consider it as a multidimensional and multivariate system of division of labour, an open dynamic interdependent system. The article dwell on the conception of engineering designing, which has a property of recursiveness so that engineering activity may design itself. The authors argue that namely activity ontology should become the basis of the new methodology of engineering pedagogy, which creates the tools for training new generations of engineers by means of continuous professional education of university teaching staff.


Objective— During inflammation, P-selectin expressed on activated endothelial cells and platelets mediates rolling adhesion of leukocytes. Atherosclerosis-prone mice crossed with P-selectin–deficient (Selp −/− ) mice develop smaller lesions. Cytokines, such as tumor necrosis factor-&agr;, increase Selp transcripts and augment atherosclerosis in mice. However, they decrease SELP transcripts in humans, challenging assumptions that human P-selectin is atherogenic. We used mice expressing a human SELP transgene to examine the atherogenic role of P-selectin. Approach and Results— We crossed apolipoprotein E–deficient (Apoe −/− ) mice with Selp −/− mice or transgenic mice expressing the entire human SELP gene (TgSELP +/− ). Aortas developed larger, macrophage-rich atheromas in Apoe −/− Selp −/− TgSELP +/− mice than in Apoe −/− Selp −/− mice after 8 or 16 weeks on a Western diet. Confocal microscopy of Apoe −/− Selp −/− TgSELP +/− aortas revealed staining for human P-selectin in endothelial cells overlying atheromas but not in lesional macrophages. We also observed staining for human P-selectin in aortic endothelial cells of 3- to 4-week-old Apoe −/− Selp −/− TgSELP +/− weanlings before atheromas developed. Furthermore, human SELP transcripts were ≈3-fold higher in aortas of Apoe −/− Selp +/− TgSELP +/− weanlings than in Selp +/− TgSELP +/− weanlings, whereas murine Selp and Sele transcripts were equivalent in weanlings of both genotypes. Human SELP transcripts in aortas of Apoe −/− Selp +/− TgSELP +/− mice remained nearly constant during 16 weeks on a Western diet, whereas murine Selp and Sele transcripts progressively increased. Bone marrow transplantation in Apoe −/− Selp −/− and Apoe −/− Selp −/− TgSELP +/− mice demonstrated that both platelets and endothelial cells must express human P-selectin to promote atherogenesis. Conclusions— P-selectin expressed by human SELP is atherogenic in Apoe −/− mice, suggesting that P-selectin contributes to atherogenesis in humans.


FIELD: medicine. SUBSTANCE: group of inventions relates to medicine and medical equipment, in particular, to devices and methods for application in refraction surgery. Device contains source, emitting laser beam, means, forming and directing said laser beam with respect to eye, camera for registering properties of iris and eye pupil, computer, which contains controlling programme and made with possibility of controlling said means in accordance with ablation profile. Method of refraction surgery, realised with application of said device consists in the fact that first determined and memorised is dependence of apex (A) position or point located at fixed distance from said apex on the surface of cornea of eye, which should be subjected to medicinal influence, on property of pupil, which can change during said procedure. After that, laser radiation in directed at the surface or inside the eye in form of preliminarily determined space-time pulse sequence, adjusted with application of said dependence in accordance with position of eye, determined by registration of instant value of pupil property. EFFECT: application of group of inventions will make it possible to achieve improved results of refractive surgery due to reduction of systematic errors by taking into account dependence of ablation centre position on pupil properties, which can change in the process of procedure. 5 cl, 2 dwg


Abstract 3-(Diethoxyphosphoryloxy)-1,2,3-benzotriazin-4 (3H)-one 1 is a new organophosphorus compound which can be used as an efficient coupling reagent for peptide synthesis by either solution or solid phase coupling. Standard abbreviations for amino acids and protecting groups follow the IUPAC-IUB Joint Commission on Biochemistry Nomenclature: J. Biol. Chem. 1971, 247, 977.


As an important part of art education,the education of aesthetics in music has a highly educational aesthetic value.It's the most directed aesthetic education of college.It pursues a comprehensive and balanced development of personality and plays an irreplaceable role in full implementation,implementation of quality education.But in the educational practice,emphasis is put on the needs of society.The cultivation of aesthetic emotion of university students is neglected.Students have a narrow scope of knowledge,and are poor in basic knowledge and artistic accomplishments.Imagination,creativity and capacity to adapt to the community are also lacked.


1°, for aperture ratios hjll '" 1, 1/4, 1/8, 1/16, and 0, where h and II are the height of the internal opening(above the partition) and the height of the enclosure, respectively, It is demon strated that the aperture ratio hfll has a strong effect on both the heat transfer rate and the flow pattern. The second part of the study consists of an asymptotic analysis of the same phenomenon, valid in the limit ofvanishing Rayleigh numbers. The flow and temperature fields in this limit are reported graphically for IIIL'" 0.5, Pr", 0.71 and 0.3 < hll! < 0.7, where Land Pr are the enclosure length and the Prandtl number, respectively.


The (tree) amplituhedron A(n,k,m) is the image in the Grassmannian Gr(k,k+m) of the totally nonnegative part of Gr(k,n), under a (map induced by a) linear map which is totally positive. It was introduced by Arkani-Hamed and Trnka in 2013 in order to give a geometric basis for the computation of scattering amplitudes in N=4 supersymmetric Yang-Mills theory. When k+m=n, the amplituhedron is isomorphic to the totally nonnegative Grassmannian, and when k=1, the amplituhedron is a cyclic polytope. While the case m=4 is most relevant to physics, the amplituhedron is an interesting mathematical object for any m. In this paper we study it in the case m=1. We start by taking an orthogonal point of view and define a related "B-amplituhedron" B(n,k,m), which we show is isomorphic to A(n,k,m). We use this reformulation to describe the amplituhedron in terms of sign variation. We then give a cell decomposition of the amplituhedron A(n,k,1) using the images of a collection of distinguished cells of the totally nonnegative Grassmannian. We also show that A(n,k,1) can be identified with the complex of bounded faces of a cyclic hyperplane arrangement, and describe how its cells fit together. We deduce that A(n,k,1) is homeomorphic to a ball.


The paper addresses the construction of a non spurious mixed spectral finite element (FE) method to problems in the field of computational aeroacous-tics. Based on a computational scheme for the conservation equations of linear acoustics, the extension towards convected wave propagation is investigated. In aeroacoustic applications, the mean flow effects can have a significant impact on the generated sound field even for smaller Mach numbers. For those convec-tive terms, the initial spectral FE discretization leads to non-physical, spurious solutions. Therefore, a regularization procedure is proposed and qualitatively investigated by means of discrete eigenvalues analysis of the discrete operator in space. A study of convergence and an application of the proposed scheme to simulate the flow induced sound generation in the process of human phonation underlines stability and validity.


The partly built line of the ECR ion source Alice, mainly based on electrostatic elements, needs several optimizations for different ion beam (A/q ranges from 2 to 9). Numerical codes easy to maintain and fast to execute were in demand. Beam optics codes are usually implemented as a kind of object oriented programs followed by a purposely written high level interpreter. This level was here replaced by general programs, combining symbolic and numerical capability, which therefore support different programming styles and a much finer physical description. Highly efficient linear tracking of electrostatic elements was obtained combining piecewise analytical solutions for quadratic and linear elements; some basic formulas and a sample result for Alice line are shown. Extension of elements to nonlinear case is given here, with detail for the anode lens.


This study was carried out in two blocks of Nabarangpur district of Orissa. One hundred twenty respondents were selected randomly having minimum 10 numbers of goats with 5 years of experience in goat rearing. Different constraints namely financial, operational, extension support, socio-cultural and marketing were analyzed in detail. Extension support constraint was ranked 1st among all others. Majority of the farmers reported that proper incentives were not given by the government. Among the different operational constraints, unavailability of feed supplements was the major problem. Farmers did not have sufficient knowledge on benefits of goat farming. Our study suggested that goat farming is done by people of lower socio-economic status who face difficulty in transporting their goats to distance market place for marketing. Government may take necessary steps to improve the knowledge dissemination through specially designed extension activities.


The National Institutes of Health (NIH) has announced that its hitherto voluntary Public Access Policy will become mandatory. This means that a final, electronic version of manuscripts describing research that received direct support from the NIH must be submitted to the National Library of Medicine


Employing attitude measures to explain valuation responses in contingent valuation studies has the potential to improve statistical analyses as well as interpretation of response information. In this paper, four types of attitude measures are compared for their ability to provide these benefits in the context of a contingent valuation of an air quality management plan for Sofia, Bulgaria. Findings show that specific attitude measures are superior to generalized attitude measures on both counts. The use of aggregated attitude indices versus single-item measures has different implications for the results, so choice of which to employ should depend upon the specific application.


Ultralong La2O3:Eu3+ single-crystalline nanowires were successfully fabricated through a large-scale and facile composite-hydroxide-mediated method followed by a subsequent heat treatment process. The as-synthesized products were characterized by powder X-ray diffraction (PXRD), scanning electron microscopy (SEM) combined with energy dispersive X-ray spectroscopy (EDS), transmission electron microscopy (TEM), and photoluminescence spectra. The product formed via the composite-hydroxide-mediated method, La(OH)3:Eu3+, can transform into La2O3:Eu3+ with the same wire-like morphology after a postannealing process. The possible mechanistic pathways for the formation of the one-dimensional (1D) La2O3:Eu3+ superstructure have been proposed. La(OH)3:Eu3+and La2O3:Eu3+ nanowires are high-surface-area materials. Under the excitation of 283 nm ultraviolet light, La2O3:Eu3+ nanowires show a strong red emission line corresponding to 5D0 → 7F2 transition at 625 nm.


Existence and uniqueness for infinitesimal dislocation based rate-independent gradient plasticity with linear isotropic hardening and plastic spin are shown using convex analysis and variational inequality methods. The dissipation potential is extended non-uniquely from symmetric plastic rates to non-symmetric plastic rates and three qualitatively different formats for the dissipation potential are distinguished.


Different groups have differing motivations for participating in language documentation projects. Linguists want to increase our knowledge of languages and linguistic theory, but constraints on their work may lead to issues with their documentation projects, including their representations of the languages they study. Native speakers participate to maintain and develop their language, and may choose to represent it in a way which showcases their culture and attitudes. In order to encourage more native speakers to take part in documentation projects, a simple integrated system is required which will enable them to record, annotate and publish recordings. Language Landscape, our web-based application, enables native speakers to publish their recordings, and Aikuma, a mobile application for documentation, enables them to record and orally translate recordings, in both cases with minimal cost and training required. Language Landscape benefits communities by allowing them to document their language as they see fit, as demonstrated by our outreach program, through which some London school children created their own projects to document their own languages and those spoken around them.


SYSTEMIC hypertension occurs as a primary condition or a complication of several diseases in dogs, and complicates several disease conditions of cats. The ability to measure blood pressure accurately and repeatably, and to interpret blood pressure measurements in the light of other patient information, is integral to the recognition and evaluation of symptomatic or asymptomatic hypertension.


Research on the effect of the ratio of sodium bicarbonate on the mechanical properties of underarm crutch pads from natural rubber SIR-20 has been carried out. The ratio of sodium bicarbonate used was 1.00 phr; 1.50 phr; 2.00 phr; and 2.50 phr. The rubber compound for underarm crutch pads was made by the compounding process using an open rubber mixing mill and vulcanization at a temperature of 120 °C for 11 minutes. The best formula for curing characteristic rheometer test results at a temperature of 150 °C was URC-04 with Smax = 4.95 kg/cm, Smin = 0.44 kg/cm, ΔS = 4.51 kg/cm, t90 = 6.57 min and ts2 = 4.13 min. The mechanical test result showed the hardness test before aging and after aging of 31 Shore A, and 32 shore A, tear strength of 8.50 kN/m, elongation at the break before aging and after aging of 300%. The results of the identification of functional groups by FTIR for infrared absorption in each sample generally showed the same pattern with one another. SEM analysis result showed the distribution of materials and the formation of pores by sodium bicarbonate was not evenly distributed with an average diameter of 5 microns.


. This paper presents the results of a usability evaluation of the NeuroSky's MindBuilder –EM (MB). Until recently most Brain Computer Interfaces (BCI) have been designed for clinical and research purposes partly due to their size and complexity. However, a new generation of consumer-oriented BCI has appeared for the video game industry. The MB, a headset with a single electrode, is based on electro-encephalogram readings (EEG) capturing faint electrical signals generated by neural activity. The electrical signals across the electrode are measured to determine levels of attention and then translated into binary data. This paper presents the results of an evaluation to assess the usability of the MB by defining a model of attention to fuse attention signals with user-generated data in a Second Life assessment exercise. The results of this evaluation suggest that the MB provides accurate readings regarding attention, since there is a positive correlation between measured and self-reported attention levels. The results also suggest there are some usability and technical problems with its operation. Future research is presented consisting of the definition of a standardized reading methodology and an algorithm to level out the natural fluctuation of users' attention levels when used as inputs.


In the 1980's, Congress passed the TEFRA legislation, which divided issues surrounding partnerships into two categories. One category can be determined during a partnership-level proceeding and the other can only be determined during a partner-level proceeding. This distinction is important because many partner defenses can only be asserted at the partner-level. Therefore if that partner is forced to litigate his issue at the partnership-level, he will not get the benefit of his defense. This problem has increased significance in tax shelter litigation case. There are many areas of partnership taxation that have confused the courts. Some courts hold that a certain issue is only determinable at the partnership-level, while other courts hold that same issue must be determined at the partner-level. This confusion leads to unpredictability and inconsistent treatment in many cases. This article examines many of these areas and suggests ways to reconcile the differences in the most fair way.


Background: Vaginal Vault Prolapsed (VVP) is defined as descent of vagina apex or vaginal cuff scar below a point that is 2 cm less than Total Vaginal Length (TVL) above the plane of hymen. VVP following hysterectomy is due to pre-existing weakness of pelvic floor tissue. Incidence is 0.2% and on clinical examination incidence is 45%. It is reported to be more common in Asian women (67%) compared to Caucasian (26%) or African (28%) women.
Methods: 15 cases of prolapse cases were operated during a period of 2 year attending our department. The efficacy of the Sacrospinous Ligament Fixation of the Vault (SSLF) was evaluated. We performed prophylactic SSLF following vaginal hysterectomy in 5 cases and therapeutic SSLF in 10 cases of vault prolapse. Surgical repair of vault prolapse is to address the need to preserve or improve the function and restore the normal anatomy.
Results: There was significant improvement in severity of prolapsed with preoperative staging ranging in stage 2 to 4 and postoperative staging in stage -3 to stage 1. Anterior vaginal wall prolapse was reduced immediate post- operative period most of the patients who had stage 2 and stage 3 were reduced to stage 1 and -3. No bladder or bowel injuries in this series.
Conclusions: SSF is suitable in physically frail women, requires lesser operating time, rapid recovery, lesser blood loss and hospital stay in addition to being cost effective with patient satisfaction (91%). Sacrospinous fixation is chosen procedure for primary vault prolapse repair.


The analysis results show that the ability of conserving water of mixed stands with the Cunninghamia lanceolata density of 1350 trees/hm 2 is strongest.The canopy layer water holding capacity is 0.545 tons/hm 2 more than that of pure C.lanceolata forests,3.049 tons/hm 2 more than that of pure P.pubescens forests.The total water holding capacity of above ground portion is 25.424 tons/hm 2,3 143 tons/hm 2 more than that of pure C.lanceolata forests and 3.309 tons/hm 2 more than that of pure P.pubescens forests respectively.The water reserve of soil layer (0~40cm) is 611.2 tons/hm 2,all bigger than that of pure C.lanceolata and P.pubescens forests as well as other mixed forests.The original osmosis value and stable osmosis value reach 60.80 mm/min and 20.32 mm/min respectively,2.8 times and 2.3 times as much as those of pure C.lanceolata forests,2.5 times and 1.6 times as much as those of pure P.pubescens forests accordingly.The annual water conservation amount is 14415 tons/hm 2,2376 tons/hm 2 more than that of barren mountains and 740 tons/hm 2 more than that of pure C.lanceolata forests respectively.


Introduction: General movements (GM) analysis is used for early detection of movement disorders in high-risk preterms or newborns with complication during delivery, e.g. GM analysis predicts infantile cerebral palsy at an age of 3 months with high sensitivity and specifity. Unfortunately, the implementation in daily clinical practise has not been achieved yet. GM analysis is a video-based analysis of spontaneous movements which needs ample training. Therefore, we investigated a computer-aided approach by using an electromagnetic tracking system (ETS). In previous works we have already demonstrated that ETS is a reliable and practicable way to record GM patterns. The aim of this study was to find methods to differentiate quality of movements. Methods: 30 infants were investigated at an age of three months (in case of preterm infants their age was corrected for their gestational age). Twenty infants were high-risk infants with intracerebral haemorrhage, periventricular leucomalacia or asphyxia. Ten healthy term infants served as controls. The classic video-based GM analysis was used to classify the spontaneous movements as normal or definitely abnormal. Simultaneously, spontaneous movements were recorded with small sensors with 6 degrees of freedom each that were attached to extremities, shoulder and pelvis. Segmental kinematics were calculated by mapping the ETS data to a 3D model. Results: In order to evaluate the variability movement frequency in single joints was plotted against time. This time-frequency-analysis on the one hand illustrated the quantity of movements and on the other hand demonstrated amplitude changes of motion. The amplitude is one aspect of variability and also of complexity of spontaneous movements. Seven infants in the high-risk group were classified as definitely abnormal by classic video-based GM analysis. Five of them showed abnormalities in the time-frequency-analysis. Infants with definitely abnormal GM findings showed movements with high frequencies and high amplitudes, whereas, those with normal GM findings showed movements with lower amplitudes. Monotony and stereotypy, which are often seen in children with movement disorders, are negative aspects of variability and complexity. Data derived from the ETS represented stereotypic movements when single ankle changes were plotted against time. They were characterized as repetitive occurring identically formed curves with similar movement amplitudes. These movements were only detected in infants with definitely abnormal GM findings. Conclusion: The quality of movements which regards variability, complexity and fluency leads to the GM categories of abnormal and normal movements. For the first time, algorithms were found to evaluate the variability besides the complexity of spontaneous movements. Nevertheless, further investigations and analyses are needed to reach the aim of an automatic discrimination of pathological infant movement patterns.


The research status of the biological nanometer holes and the solid nanopore are reviewed.The α-HL hemolysin hole,preparation of biological nanopores and artificial solid-state nanopore sensor as well as detecting of single molecule and determination of the DNA sequencing are focused on.The development trends and application prospect are discussed too.


Geological condition of Zhengbang well in Juye coal mine is very complicated in Shandong province.Its major coal strata are No.16 coal stratum of Carbernious Taiyuan formation,which belongs to thin coal strata exploration areas.According to seismic geological conditions and by using seismic exploration countermeasures with high distinguishing degree,faults,occurrence scope of No.16 coal stratum is studied.As proved by drilling experience,good seismic exploration precision and efficiency are gained by using this method.


In this paper we show that a simply connected 8-dimensional manifold M of positive sectional curvature and symmetry rank � 2 resembles a rank one symmetric space in several ways. For example, the Euler characteristic of M is equal to the Euler characteristic of S 8 , HP 2 or CP 4 . And if M is rationally elliptic then M is rationally isomorphic to a rank one symmetric space. For torsion-free manifolds we derive a much stronger classification. We also study the bordism type of 8-dimensional manifolds of positive sectional curvature and symmetry rank � 2. As an illustration we apply our results to various families of 8-manifolds.


Describes why modern engineering plastics have supplanted or superseded traditional materials such as wood and metal in a wide range of applications and in particular in wear‐part or bearing applications. States that the most important factor in choosing plastic bearings is their ability to withstand wide variations in load over a long period of time, yet operate with very good reliability despite an unpredictable maintenance routine; the so called "fit and forget" ability. Discusses in depth the application of composite materials in the production of bearings for off‐shore and marine use including rudder bearings, steering gear support and stern tube bearings.


SUBTITLE: DESPITE THE SHOWDOWN OF GROWTH IN ASIA, BANGKOK WILL NEED ADDITIONAL AIRPORT CAPACITY IN THE FUTURE: BUT OSCILLATING GOVERNMENT POLICY AND THE CURRENT FINANCIAL CRISIS IN THAILAND LEAVES BANGKOK'S SECOND AIRPORT PROJECT IN THE SLOW LANE WHILE EXPANSION OF DON MUANG IS GOING AHEAD.


Cognitive load refers to the amount of working memory that is being used in a task, like memorizing the anatomical landmarks on distinct boney specimens. Critically, cognitive load may be compromised when the load imposed by the environment and the content to be learned together exceeds a student's capacity. Previous research shows that stereoscopic materials delivered in virtual reality (VR) can be more mentally taxing compared to desktop (i.e., two dimensional) delivery but may be similar to that encountered in real life. There is no data on the cognitive load of autostereoscopic displays. Given the increased reliance upon digital media for teaching in learning in anatomy classrooms, it is prudent to better understand the cognitive load imposed on learners across a variety of modalities employed.


The speech signal processing is the cross-discipline which combines the voice science with the digital signal processing technology.The voice is taken as a special signal,i.e.a complex vector.By using the command functions in the digital signal processing tool-MATLAB,the digital signal processing can solve many problems.The spectrum of voice signals are analyzed,which is the same as the spectrum analysis of common signals.A variety of digital filters(FIR low-pass filters,high pass filters,band-pass filter and IIR band stop filter) are used to filter and analyze the voice,and the voice signals are compared with the original signal.Finally,the conclusion is drawn.


ABSTRACT In the process of high casting speed, the study of funnel mould (FM) cooling process is particularly important. Based on the copper plate temperature measured by thermocouple, a mathematical model of the inverse heat transfer problem of the thin slab/copper plate was developed to calculate the boundary heat flux, then a positive mathematical model of thin slab/copper plate/cooling water coupled heat transfer has been developed, and the influence of the cooling water flows from top to bottom in the water channels on the heat transfer behaviour of the FM copper plate was analysed. The results show that when the cooling water flows from top to bottom in the water channels was adopted, the peak temperature of the copper plate hot face decreased 117°C, the maximum temperature of the cooling water decreased 24°C. Cooling water velocity and temperature have little influence on heat transfer of copper plate.


The first supermarket refrigeration system in the Netherlands with only natural refrigerants became operational in March 2004 and is located in Bunschoten. The NH3/CO2 cascade system has NH3 as primary refrigerant evaporating at -16 °C in two parallel cascade heat exchangers, where CO2 is condensing at -12 °C. One CO2 circuit is used for the cooling, which is an innovation for supermarket refrigeration. From the cascade heat exchanger, CO2 is pumped into the cooling section. In the other CO2 circuit, direct expansion and a CO2 compressor provides the freezing section with CO2 of -30 °C. The most experiments with CO2 in supermarkets in Europe have been restricted to the application of CO2 in the freezing section. Therefore, the application of CO2 as a phase-changing secondary refrigerant in the cooling section is an interesting innovation. The technical, energetic and economical aspects of the installation are considered. The technical operation of the cascade refrigeration system in a supermarket is discussed. The energy savings are calculated and the installation and running costs evaluated. Experiences and problems during the installation and control of the installation are discussed.


Materials Science
Polymer gels can be thought of as a netlike structure of cross-linked linear polymer chains swollen with solvent. Because these materials are mostly liquid, they can be quite soft and squishy, but this means that solvent loss, which makes the gels sticky, also is a concern. Cai et


Objective To evaluate the clinical effectiveness of the combined use of S1 pedicle screws and the iliac screws in treatment of sacroiliac dislocation and fracture. Methods 11 patients with sacroiliac dislocation and fracture were treated with S1 pedicle screw and iliac screw fixation technique. In this group, the dislocation was associated with vertical displacement of the sacroiliac joint and rotational deformity of the pelvic ring. They were classified as type B or type C pelvic disruption according to the Tile's classification. 7 patients with disruption of the symphysis pubis or pubic branch fracture underwent additional fixation of the pelvic ring using a reconstruction plate. The remaining 4 patients were treated by the posterior procedure alone. Results The vertical displacement was completely reduced in 7 patients, and the rotational deformity completely corrected in 4 patients. The reduction was maintained at the time of final follow up evaluation. No perioperative complications were found. The combined use of S1 pedicle screws and the iliac screws provided immediate stability and sufficient reduction for sacroiliac dislocation in the 11 patients in this study. Conclusion This hybrid internal fixation procedure is useful for reduction and fixation of sacroiliac dislocation associated with the vertical and rotational instability of the pelvic ring.


OBJECTIVE
To establish a new extrahepatic growing hepatocellular carcinoma cell line.

METHODS
A specimen from extrahepatic growing hepatocellular carcinoma was cultured in vitro. Cancer cells were studied morphologically and subjected to karyotype analysis, DNA analysis, and tumor formation evaluation.

RESULTS
Morphological observation and functional analysis showed that their features were similar to those of HCC. Chromosomes with a variation of 76 approximately 104 were able to secret AFP in vitro and to form bile canaliculi with microvilli.

CONCLUSION
EGHC-9901 cell line has characteristics of the extrahepatic growing hepatocellular carcinoma.


Joint Russian - Vietnamese expedition aboard the research vessel "Akademic Oparin" organized by the Pacific Institute of Bioorganic Chemistry (PIBOC) and the Institute of Marine Biology (IBM) of the Far  East Branch of the Russian Akademy of Sciences (FEBRAS) together with the Institute of Oceanography (IO) of the VAST, Vietnam, from 05/5 to 08/6/2007 in the Economic zone of Vietnam sea. A main goal of the expedition is investigation of Biochemical and Biological diversity of main invertebrates, algae and microorganisms of a shelf of Vietnam and coral reefs of the Bien Dong. - The primary results of the investigation allowed us to access the status of coral reefs in the coastal and open waters of Vietnam. The reefs in the coastal waters have tended to be degraded severely due to the over-exploitations of resources by the exterminating methods. - During the expedition, we collected plenties of the precious specimens which are usefull for scientific  study and Oceanographic meseum. Among them, several samples are found at the first time in the deep sea,  such as white sphere sponge, pieces of gabro stone, red coral, and other veterbrates living in the bottom. - Total of samples collected during the investigation: Geological samples: 35 Biochemical samples: 39 Microbiological samples: 51 samples (263 strains) Soft coral samples: about 150 Specimens for Oceanographic meseum: about 200


We would like to present the numerical procedures of constructing the finite energy SU(2) Yang-Mills-Higgs particles of one-half topological charge. Four types of numerical one-half monopole solutions, Type A1, Type A2, Type B1, and Type B2 solutions have been found from our numerical calculation and comparison are made to investigate whether they are distinct solutions. Our analysis shows that there are two numerically distinct configurations with different total energies, energy density distributions and magnetic dipole moments, namely the Type 1 (A1 and B1) and Type 2 (A2 and B2) respectively. Through our numerical analysis we are able to conclude that the Type A (A1 and A2) and Type B (B1 and B2) solutions are exact 180° rotation of the z-axis about r = 0 of one another. In order to check our numerical accuracy, the calculations are performed by using two different grid sizes, 70 × 60 and 90 × 80, to cover the whole integration regions. We are able to obtain higher accuracy graphs from the latter set ...


The intestinal microbiome consists of thousands of microorganisms and has a unique profile in each individual. This has a direct role in relationship to the host's health and disease, as it produces short - chain fatty acids (SFA) that has immunological and anti-inflammatory actions, as well as metabolism homeostasis and the perfect intestinal functioning. Knowing that this microbiome is modulated by external factors such as birth form, stress, diet, lifestyle and physical activities; this is a literature review based on 22 main articles which focus on the direct and indirect influences that physical activity exerts on the microbiome. The review considers the types of exercises, their intensity level, and the use of subterfuges that can favor intestinal microorganisms, such as probiotics, prebiotics and symbiotics.


This study investigated the effectiveness of using Google Docs in collaborative concept mapping (CCM) by comparing it with a paper-and-pencil approach. A quasi-experimental study was conducted in a physics course. The control group drew concept maps using the paper-and-pencil method and face-to-face discussion, whereas the experimental group employed Google Docs to create concept maps and used Google Chat for discussion. Learning achievements, physics concept representation, attitudes toward science, and attitudes toward CCM were examined to identify the differences between the two groups and the effectiveness of Google Docs. The results suggested that the use of Google Docs did not significantly affect physics achievement. However, Google Docs fostered physics concept representation and enhanced attitudes toward science. Moreover, the Google Docs group tended to learn more collaboratively. The students in this group also agreed with the superiority of observation and modification functions provided by the real-time co-editing mechanism and revision history.


ABSTRACT The Medicine Hat Sandstone is a coarsening-upward, marine succession of very fine- and fine-grained sandstones with intercalated mudstones, which attains a maximum thickness of 45 ft and frequently terminates upward in a characteristic sequence of lithologies: 1) up to 20 cm of strongly indurated, calcite-cemented sandstone; 2) several centimetres of acicular calcite in interfering conical aggregates, and 3) a bentonite bed, up to 2 cm in thickness. The strongly indurated sediments reflect preferred cementation of the most permeable deposits in a lithologic sequence characterized by upward-increasing permeability. Each layer of acicular calcite was formed on strongly indurated sediment beneath soft, cohesive and impermeable bentonite, through growth of conical aggregates of crystals on shear planes, propagated within the developing layer in response to a lateral stress system, resulting from continued growth of early formed crystals.


Purpose. The purpose of the article is to summarize theoretical approaches to determining the nature, structure and sources of innovative potential of a region.

Methodology of research. The following methods are used during the study: systemic and dialectical – to study the dominant characteristics of the region's innovation potential; comparison and synthesis – to study approaches to interpreting the term "innovation potential"; graphic – for a visual representation of the results of the study.

Findings. The approaches to the interpretation of the above category are summarized based on the study of scientific literature devoted to the problem of innovation potential, as well as three main approaches to the interpretation of innovative potential: resource (most common), target and approach by which innovative potential is considered as a measure of ability / result oriented).

It is suggested that the innovative potential of a region means first and foremost the opportunities, and second, the resources and organizational capabilities that enable the creation and implementation of innovations to achieve sustainable development of the region and the country as a whole. At the same time, an important aspect of increasing the innovation potential of the region is, among other things, the institutional capacity of the state to stimulate and support the development of innovation processes.

It is proposed to consider financial and investment, material and technical (industrial), research, market, information, intellectual-personnel and marketing potentials as components of the region's innovation potential.

Originality. The paradigm of innovation potential of the region has been developed, which, unlike the existing ones, provides for: 1) systematization of preconditions for formation and factors of influence on development and enhancement of innovation potential; 2) establishment of functions and sources of innovative potential; 3) determination of components of innovative potential with indication of their quantitative measuring instruments and methods of measurement.

Practical value. The obtained results of the research will be the basis for the development of the author's methodology for complex evaluation of innovative potential of Ukrainian regions.
Key words: innovations; innovative development; innovative potential of the region; region; innovative activity; spatial development; regional economy.


Vector architectures have long been the of choice for building supercomputers. They first appeared in the early aeventies and had a long period of unquestioned dominance from the time the CRAY-1 was introduced in 1976 until the the appearance of "killer micros", in 1991. They still have a foothold in the supercomputer marketplace, although their continued viability, in the face of micro-baaed parallel aystens, is being seriously questioned. We present a brief hiatory of supercomputing and discuss the merits of vector architectures. Then we relate the advantages of vector architectures with current trends in computer system and device technology. Although the viability of vector supercomputers is indeed questionable, largely because of coat issues, we argue that vector architectures have a long future ahead of them - with new applications and commodity implementations. Vector instruction sets have many fundamental advantages and deserve serious consideration for implementation in next generation computer systems, where graphics and other multimedia applications will abound.