As wind turbines are usually clustered in wind farms, knowledge of the evolution of the wind turbine wakes is important because downstream turbines will be exposed to them, causing higher loads and maintenance times. For that reason, wind turbine wakes have been studied intensively and different engineering wake models were derived. However, none of them is constructed from a few basic and robust assumptions, while such a formalism already exists for the axisymmetric turbulent wake. Therefore, we will apply these models to data obtained in a wind farm using a scanning LiDAR. The wakes of two wind turbines are analyzed in four different wind directions chosen so that their wakes will have different degrees of interaction. The axisymmetric wake models are found to perform better than the Jensen wake model, and the main source of improvement is shown to be the presence of a virtual origin. Indeed, a virtual origin is shown to also improve the Jensen wake model significantly. Overall, our results indicate that a view from classical axisymmetric wake theory can help to improve the understanding of the evolution of wind turbine wakes in the atmospheric boundary layer.


Purpose - The purpose of this paper is to investigate the relationship between bank-specific characteristics and profitability in European banking sector to find the role of internal factors in achieving high profitability. Design/methodology/approach - A regression analysis is built on an unbalanced panel data set comprising 175 observations of 35 top European banks over the period 2009-2013. To this end, the empirical data are collected from Bankscope and a comprehensive set of internal characteristics is examined. Findings - All the determinant variables included in the model have statistically significant impacts on European banks' profitability. However, the effects are not uniform across profitability measures. Regression findings reveal that size and capital ratio are significant company-level determinants of bank profitability in Europe, while higher loan loss provisions result in lower profitability levels. Findings also suggest that banks with higher deposits and loans ratio tend to be more profitable but the effects on profitability are statistically insignificant in some cases. Practical implications - This study has considerable policy implications, as the performance of the European banking sector depends on its efficiency, profitability and competitiveness. In view of these findings, some suggestions may be functional for bank regulatory authorities to intensify and sustain robustness and stability of the banking sector. Originality/value - The results provide interesting insights into the characteristics and practices of profitable banks in Europe. Few econometric studies have empirically explored the determinants of bank profitability in Europe so far, even though similar studies have been conducted in several developed countries. Therefore, this paper tries to close an important gap in the existing literature improving the understanding of bank profitability in Europe.


Background

At the Queensland University of Technology, medical imaging students complete a total of 22 weeks of clinical experience during their three year degree program. In order to ensure that students are equipped with the appropriate skills to become insightful and thoughtful professional practitioners, we have embarked on a program of embedding reflective practice with the units of study.

Learning Objective

To describe a method of providing a scaffolded learning approach to embedding reflective practice.

Method

This presentation will outline the strategies and tools adopted to assist the student learning experiences. The development of reflective skills starts initially in first year with a simple reflective journal page which asks student to describe what they have learned in that week, to consider the value of those learnings to professional practice and then to identify any further learnings which are needed to enhance their knowledge. Within the preclinical skills development units of study, students are given critique forms to assist them in developing an analytical reflective approach to reviewing their images. In the subsequent clinical units of study this is carried into reflective case study reports where as well as providing a critical analysis of outcomes of the examination in terms of image production, the management of the patient and patient care aspects and outcomes of the interaction. This requires a student to provide comment on more than the technical nature of the case and focus on the patient. During later semesters students complete imaging tasks to determine competency. For each case the student is required to complete a patient examination from beginning to end which is observed by their supervisor. The imaging examination is viewed holistically and the student assessed on their overall performance. The student then completes a short written review of the patient history and imaging study, plus their reflections on the outcome in relation to patient management and a self assessment of their performance. There are multiple competency tasks to be achieved and whilst it may take a while, students can with practice become more insightful in their assessments of their professional practice.

Conclusion

Reflection and self assessment of professional performance are not skills that are readily taught in a conventional didactic environment. It requires a measured approach to introduce the building blocks of knowledge and the skills to analyze and reflect. By beginning in first year with simple questions and cues, through reflections on outcomes, to self assessment of professional practice in the final year, students are equipped to graduate with the capabilities required of a medical imaging professional.


Objective To evaluate the value of ultra-early MR angiography in the judgement of the prognosis of acute ischemic stroke patients.Methods The acute ischemic stroke patients who underwent MR angiography within 6 hours after onset were studied.Before MR was performed,National Institutes of Health Stroke Scale(NIHSS) scores were obtained.All patients were followed for three months after onset and modified ranking scale(mRS) scores were recorded.Results Between June 2005 and March 2006,44 stroke patients fulfilled all inclusion criteria.Time from symptom onset to MR angiography ranged from 84 to 348 minutes.In 21 patients with visible occlusion on ultra-early MR angiography,after three months,mRS was ≤2 in only 6 patients,indicating a poor outcome in this group.In 23 patients without visible occlusion,after three months,mRS was ≤2 in 19 patients.The difference of clinical outcome between the two groups was significant(P0.001).Conclusions Whether there is visible occlusion on ultra-early MR angiography or not may help in judging the prognosis of acute ischemic stroke patients.


The global demand for energy is increasing daily due to the constant growing of the civilization with the expansion of energy infrastructure and the addition of new needs. This load increments added to fossil fuels crisis and the global economic crisis, arises the need to minimize both the electricity consumption and the economic expenditure [1][2].
The National Grids operates the transmission network that connects power stations to electricity consumers. Is also responsible for balancing the demand and supply system and ensuring that power stations will be able to provide electricity in case of an unanticipated increase in electricity [3]. As energy cannot be stored it must be generated according to demand, in order to avoid both the wastage of energy sources as the economic one. [4] So, this is what this Thesis is about, study different algorithms capable of predicting load consumption.


Functional hearing loss (FHL) is a hearing problem without actual pathology, including auditory malingering and psychogenic hearing loss. Because most FHL children are considered to have psychogenic hearing loss, they are in particular need of psychological diagnosis and support. In our department, otolaryngologists and a clinical psychologist perform team treatment for FHL children, attempting treatment from both physical and mental aspects for purposes of research. In this study, earlier literature about psychological clinical features in FHL children was reviewed, and 126 examples were screened from the period from April 2000 to August 2014 and statistically reported. In addition, the FHL children were classified into three groups from the psychological viewpoint –auditory inattention group, repressive conversion group and over-adaptation group– and psychological treatments were discussed using examples.


Allan Mann, a long-standing member of The Structural Engineer Editorial Advisory Group, looks back at the publication's history as it marks its centenary.


The present invention provides a real-time ultrasound monitoring system. Such a real-time ultrasound monitoring system according to the present invention is to be able to be carried out is firmly fixed in close contact to the non-planar portion including a curved surface to be because the ultrasonic inspection is performed by the ultrasonic inspection regardless of the shape condition of the object accurately and reliably, as the ultrasonic signal of the object by a piezoelectric element arranged in two-dimensional monitoring, real-time generating a 3D ultrasound image of the object so that a response to the diagnosis and the inspected object defects in the inspected object can be quickly and efficiently . Probe which is arranged on the real time ultrasound scan surface monitoring system inspected object (1) according to the invention, provided with a plurality of piezoelectric a two-dimensional array by setting the pattern elements 11 perform ultrasonic inspection of the inspected object (1) 10 and; And a fixture 20 for fixing the transducer 10 in place; The transducer output device (30) for receiving transmission information from the ultrasound signals (10) output by calculating a ultrasound image of the object (1) from the current ultrasound signal and information received; It consists of a configuration that includes a controller 40 for controlling the operation of the transducer 10 and the output device 30.


At the moment there is an urgent need in discussing the requirements to the description order for widespread HPLC methods in normative documents on the quality control of medicines. Lack of modern domestic quality standards, regulatory requirements and the usage procedure for physical and chemical test methods in general and HPLC method in particular, resulted in the need to rely on the experience of foreign pharmaceutical community in terms of guidelines, recommendations, general pharmacopoeia chapters and pharmacopoeia monographs. The requirements to the description order of HPLC methods in normative documents on the quality control of medicines, taking into consideration the importance of the mentioned method in drug quality assessment are discussed. The urgency of the issue of developing and approving common approaches to the description of all the sections in regulatory documents, including the conditions for HPLC analytical method is outlined. Typical errors in the descriptions in relation to their critical impact on methods adequacy and repeatability. The performed analysis allows to clarify the requirements of the FSBI «SCEEMP» Commission of Experts to applicants in terms of HPLC methods information content, it also helps to simplify the process of the expert evaluation of drug quality of medicines and reduce the number of comments to HPLC methods.


A strain of degrading feather keratin bacterium with high efficiency was isolated from environment by adopting the culture medium taking feather meal as sole carbon and nitrogen source.This strain was identified as Bacillus pumilus by morphology,physiological and biochemical experiments and 16SrDNA gene analysis,and named as the Bacillus pumilus WHK4.The degradation rate of feather keratin reached to 85.76% after 48h fermentation.The results indicated that WHK4 was an appropriate strain for exploring microorganic fermentation system to degrade feather keratin,and had a great potential to be applied in producing high quality protein feed.


With the rapid advancements in artificial intelligence and connected systems, understanding users' perceptions becomes crucial. This study delved into the "Perception of Updates" in intelligent systems, combining expert and user interviews to elucidate the various facets of perceived system upgrades.For a deeper dive, semi-structured interviews were carried out with experts and users alike. The expert group consisted of professionals from diverse fields, including user experience, product design, intelligent vehicle design, voice system specialists, and academics, all of whom have substantial experience in the domain. Key insights from these sessions ranged from the evaluation of intelligent product upgrades to discerning design recommendations under perceived enhancements.On the other hand, user interviews engaged 20 users with experience in using intelligent products. The focal point here was their experiences and recall of moments when they distinctly perceived an update or progression in the intelligence of the systems they used.Emerging from these interviews were structural analyses of the perception of updates. Three primary dimensions were discerned: enhancement of perceived functions, addition of new functions, and perceived evolutionary capabilities of the system. Notably, there were also implications on the effects of this perception. Positive outcomes included increased trust in the product, heightened purchase intentions, brand loyalty, a sense of security, and a propensity to recommend the product to peers. Interestingly, among user interviewees, the perception most significantly influenced product recommendations and brand loyalty. Meanwhile, experts highlighted the implications on brand loyalty and trust, reinforcing the intrinsic link between perceived updates and continued user engagement. However, there were also potential drawbacks to consider, such as concerns over privacy and perceived threats, though these were less frequently mentioned.This study highlights the importance of understanding user perceptions of system updates, offering valuable insights for improving user experience in modern technology.


Two new double-armed benzo-15-crown-5(2 and 3) were synthesized by reaction of 4,5-bis-(bromomethyl)-benzo-15-crown-5 with 2-naphthol and 2-mercaptobenzothiazole, respectively, and characterized by elemental analysis, mass, IR, -{-}~1H NMR spectroscopies and X-ray diffraction, respectively. The crystal structure of compound 2 was reported as follows: Crown ether 2 crystallizes in the monoclinic system, space group P2_1 with cell parameters: a=1.262 2(9) nm, b=1.224 7(9) nm, c=2.016 0(16) nm, β=101.270(15)°. There is an intermolecular π-π interaction among layers along c axis in the crystal. The cation binding abilities and selectivities of them were evaluated by solvent extraction of aqueous metal picrates. The results obtaine indicated that crown ether 2 showed a high extractability and selectivity for potassium ion and thallium ion, while crown ether 3 displayed a high extractability and selectivity for silver ion.


Objective To standardize the blood collection process in the hospital and ensure the safety of clinical use of blood through establishing an information management system for blood collection and supply.Methods The system was developed on the basis of the C/S(client/server) structure and PowerBuilder 10.5 visual programming languages,which endowed the system with user-friendly operation interfaces.Then,the data interface was built up between the HIS(Hospital Information System),LIS(Laboratory Information System) and the system so as to share medical data.Results The interconnection and data sharing among the systems realized the real-time and full-course monitor and follow-up of every bag of blood from its collection to clinical use.Conclusion Real-time maintenance for the blood transfusion subsystem of HIS by Department of Blood Transfusion can further ensure the blood quality and the safety of clinical use of blood.


Introduction: Osteosarcoma (OS) is the most common primary malignancy of the skeleton, and inordinately affects young adults. Despite improved outcomes with current multimodal care, the prognosis for patients with metastatic disease is grim. Peripheral neural regulation of cancer growth has long been suggested by clinical observations in pancreatic and prostate cancers. Prior reports suggest peripheral nerve sprouting in osteosarcoma, but the functional roles of sensory nerves in osteosarcoma are unknown. Here, the role of TrkA+ sensory nerves in OS disease progression was assayed.
 Methods: All experiments were conducted under IACUC approval at Johns Hopkins University. TrkAF592A mice which are homozygous for a phenylalanine-to-alanine point mutation in exon 12 of Ntrk1 gene were crossbred with NOD scid mice (TrkAF592A/Scid). TrkA inhibition was performed by 1NMPP1 treatment. In vivo tumor growth was examined using a periosteal xenograft model. 1 million human 143B-luc OS cells were injected. Analysis was performed using serial measurements of tumor size and IVIS imaging. Nerve distribution and macrophage polarization within the tumor microenvironment was documented using immunostaining for Beta III Tubulin (TUBB3), CD86, CD206 and F4/80.
 Results: Inhibition of TrkA led to a significant reduction in Tubb3+ nerves (88.4%) within and around the OS xenografts. In addition, tumors within TrkAF592A/Scid animals demonstrated slower growth, including a 51.5% reduction in tumor size and 60.0% reduction in IVIS luciferase activity at 4 wks. Histologic examination showed a reduction in macrophage infiltration and reprogramming of macrophages from an M2-like to M1-like phenotype in tumors with chemical denervation. Remarkably, this was associated with a reduction in Ki67 proliferative index (80.1%) and CD31 immunofluorescent staining (60.8%) within the tumors. Overall survival of mice with TrkA inhibition was significantly prolonged (p=0.0003). Retrograde tracing identified the sensory nerve fibers innervating the periosteum originated from L3-L5 lumbar DRGs and RNA seq identified OS-derived neurotrophins and axon guidance molecules.
 Discussion: Disruption of TrkA+ nerves significantly mitigates OS disease progression in a mouse xenograft model, including a significant improved overall survival. These findings are associated with a reduction of macrophage infiltration and macrophage re-polarization. Ongoing studies are examining the molecular mechanisms that mediate nerve-to-macrophage interaction in peripheral nerves and DRG neurons using a combination of sequencing approaches.
 Significance/Clinical Relevance: Sensory neurons positively regulate osteosarcoma growth and disease progression. Use of chemical or microsurgical approaches to denervate tumors may represent a future adjunctive therapy to both improve pain and prognosis in high grade bone sarcomas.
 Citation Format: Qizhi Qin, Sowmya Ramesh Ramesh, Thomas L. Clemens, Aaron W. James. TrkA+ sensory neurons modulate macrophage phenotype in osteosarcoma. [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 3630.


 Patient demographic characteristics appear to contribute to success with AV fistula; at younger ages, the percent of AV fistulas that successfully mature is higher and the median time to first use is somewhat shorter (Table 3.7). Males had a higher AV fistula maturation rate compared to females, as well as shorter time to first use. Blacks experienced the highest AV fistula maturation failure rates, compared to other races.


HMG-Coa reductase inhibitors (statins) have gained a tremendous effect on huge populations. Changing life expectancy and changing natural history of natural humans, considered at risk to develop cardiovascular disease, and patients with known cardiovascular disease. Over the years it has become clear that the major clinical effect induced by statins is not solely due to a lipid profile positive change, but also due to other effects known as the "paleographic effects" of statins (all the beneficial effects of statins besides the lipid lowering effect). A better understanding of statins of mechanistic pathways strengthened even more the paleographic significance of the beneficial effects of statins, and some even suggest that the lipid lowering effect could be actually a marker of the other, more significant effects-like the effects of statins on vascular inflammation and plaque stabilization, immune modulation, on circulating endothelial progenitor cells and endothelial cells, up-regulation of endothelial nitric oxide synthase (e-NOS) modulation of thrombosis and coagulation. All the activities and effects of statins have been discovered in the last decade and are dependent on regulation of nuclear factor K B (NF-k-B), cell adhesion molecules' activation, PI3k-Akt pathway, Rhs/Rho-kinase and activation of Akt.


A method for fabricating a semiconductor thin film transistor is disclosed. The method for fabricating the semiconductor thin film transistor comprises the steps of: a) forming a gate wire(13) having a plurality of hemisphere grains on a surface of a semiconductor substrate(21); b) forming a gate insulating layer(22) and a semiconductor layer(212) on the gate wire(23) of the semiconductor substrate(21); and c) forming an impurity region(29) on both sides of the gate wire(23). Thereby, since the length of the gate is reduced, an off current due to a short channel offset is increased and an electrical property of the semiconductor device is significantly improved.


Ab initio molecular dynamics simulations were performed to investigate the effect of similar elements on the short- to medium-range atomic packing features in Ce70Al30and La70Al30glass-forming alloys. 4f electrons of Ce element in Ce70Al30 alloy were properly treated in electronic calculations. The local atomic structures in both alloys are qualitatively similar. However, the local environments of Al atoms in Ce70Al30 alloy show fluctuation with temperature in the cooling process, which could result from 4f electrons of Ce elements. Surprisingly, the medium-range atomic packing features of Al atoms in both MGs are quite different, although Ce and La elements are similar. These findings are useful for understanding the enhanced glass-forming ability by similar element substitution in RE-based MGs from a medium-range structure perspective.


Oxygen uptake at clarifier weirs was investigated for both clean water and primary wastewater. A pilot-scale model with cross-sectional geometry similar to clarifier weirs was constructed to carry out the study. The drop height, type of flow regime over the weir, hydraulic loading, and weir shape were identified as important parameters influencing mass transfer. Empirical correlations predicting oxygen uptake were developed for different weir configurations. A correlation using the α-factor was developed to predict the oxygen transfer in primary wastewater using clean water. These correlations are a first step in estimating volatile organic compound emissions for wastewater flows over clarifiers at wastewater treatment plants.


The research objective was to describe the phenomenon of pedagogical tact in the context of the cultural and moral traditions of Russian and foreign pedagogical practices. The authors used comparative historical analysis of scientific-pedagogical and historical-pedagogical sources, chronological and comparative methods, and generalization of historical and pedagogical data. According to deontological approach, pedagogical tact is a professional agreement on teacher's standards of conduct, while the moral-cultural approach views pedagogical tact as a component of teacher's moral culture and manners. Thus, there is a contradiction in these interpretations of pedagogical tact, which is aggravated in Russia by standardization of pedagogical activity.


The dry litter system can help manage and utilize wastes while promoting a healthy and clean environment. The dry litter system allows farmers to manage swine wastes without using a lot of water. Enclosed pens on sloped concrete floors are covered in a deep layer of litter material such as wood chips or husks from coconut, corn, or macadamia nut. The sloping floors and the hoof action of the swine allows the litter material and the swine wastes to mix together and, with gravity, flow out the lower end of the pen into a holding trench. New litter is added at the higher end of the sloping pen to replace the old litter that falls into the trench.


Attribute relation learning is important, but has been few studied. This paper proposes hybrid strategies for attribute relation acquisition from candidate attributes. The composition of candidate attributes is firstly analyzed and subdivided into three types: non-attribute vocabularies, invalid attribute, and valid attribute. Secondly, the HowNet-based filtering strategy is presented which filters out the non-attribute vocabularies and invalid attributes from the candidates using the knowledge of ldquois-ardquo relations and attribute-host relations described by attribute sememe in HowNet. Thirdly, the pruning strategy based on domain concept tree is proposed to further perfect the associations between a concept and its candidate attributes. We define some pruning rules through which some redundant, unreliable, even wrong attributes can be discarded from candidates and some lost attributes can be recalled. Our results about attribute relation learning show the efficiency of our hybrid strategies.


The Middle English romance Amis and Amilon propounds an aspirational message for its audience that being hend (noble) and trew leads to both an earthly and a heavenly reward: lasting companionship. One must be a true friend and be completely loyal to one's companion in all circumstances. Friendship is described as a sacred bond in the same terms as marriage, although marriage is shown to be secondary to it: the wife's role is to support her husband and his sworn brother. Those who oppose this relationship or seek to thwart or supplant it are described in the strongest terms as treacherous, envious, and even evil. True friendship thus becomes an absolute good, and loyalty to it a measure of goodness. This article foregrounds the romance's negotiation of religious and secular bonds and, in contrast to other critical interpretations of the text, argues that its dynamic may be most appropriately read in the light of contemporary theologies of friendship, particularly those of Aelred of Rievaulx and Richard de...


1 The aim of the present study was to clarify the effects of landiolol, a short‐acting selective β1‐adrenoceptor blocking agent, on mechanical and metabolic changes in postischaemic perfused hearts. 2 Rat isolated hearts (n = 30) were randomly separated into non‐ischaemic or ischaemic groups. The latter group was further divided into Krebs'–Henseleit solution (KHS)‐ and landiolol (30, 100 or 300 µmol/L)‐treated groups. Ischaemic hearts were subjected to 25 min global ischaemia and 20 min reperfusion under atrial pacing. Time‐course changes in left ventricular (LV) end‐diastolic pressure (LVEDP), LV developed pressure (LVDP), peak positive velocity of change of LV pressure (LVdP/dtmax) and coronary flow were observed along with tissue contents of adenosine triphosphate (ATP), creatine phosphate, inorganic phosphate (Pi), malondialdehyde (MDA) and lactate dehydrogenase (LDH) release in coronary effluent. The effects of landiolol on rat isolated aortic preparations under KCl contraction were also investigated. 3 Ischaemia–reperfusion significantly impaired cardiodynamics, such as LVEDP, LVDP and LVdP/dtmax, decreased myocardial ATP content and increased Pi and LDH release. In the 30 µmol/L landiolol‐treated group, cardiovascular parameters impaired by ischaemia–reperfusion and increased LDH release were further exacerbated and myocardial MDA content was significantly increased. In the 300 µmol/L landiolol‐treated group, cardiac contractile dysfunction was improved and myocardial MDA, ATP and Pi contents were preserved. All measurements in the 100 µmol/L landiolol‐treated group were similar to those in the ischaemic KHS group. Furthermore, significant relaxations of isolated aortic preparations were obtained with landiolol 30–1000 µmol/L, suggesting a possible calcium antagonism with landiolol. 4 In conclusion, landiolol, at low concentrations, aggravated myocardial ischaemia–reperfusion injuries, whereas at high concentrations it ameliorated them. The former effect may be mediated by the production of reactive oxygen species, whereas the latter may involve calcium antagonist activity.


Three dimension wheel rail contact geometry is taken into account in studying the vibration between bridge and vehicle.The iteration method of wheel rail creep force is proposed to improve the existed calculating method.


Aiming at energy saving and reducing its consumption,the paper analyzed the affecting factors of surface system efficiency,and expounded the ways and measures to improve the surface system efficiency.By using a series of comprehensive measures such as balance optimization,reasonable use of matching motor,and strengthening production management,promotion and application of energy-saving equipment,which include reactive power compensation device,energy-saving transformer,pumping unit box,centralized control and energy-saving device,efficient motor,energy-saving pumping.AU these are to improve the power quality of pumping well,improve the efficiency of the motor and improve the efficiency of pumping.The surface energy consumption of pumping well is reduced in Ansai oil field.


Objective To study the effect of suramin in combination with DDP on the growth,lung metastasis and expression of bFGF of lung adenocarcinoma LA795 in vivo in mice. Method 32 T739 mice bearing high metastatic LA795 cells were randomly divided into four groups: control group,DDP group,suramin group,and DDP + Suramin groupe. Different treatment therapy were served from day 4 after transplantation and all mice were sacrificed after 24 days. lung and subcutaneous tumors were processed for histological examination. The metastatic tumor foci on lung in mice,Lung metastatic occurring rate and metastatic foci inhibitory rate were counted. Subcutaneous tumor microvessel density (MVD),and the expression of basic fibroblast growth factor (bFGF) were detected by immunhistochemical method with image analyse system. Results In every treatment group,tumor growth was suppressed significantly. Intraperitoneal injection of DDP,suramin and their combination resulted in significant inhibition on the growth of LA795 cells in vivo (P 0.05),the combination group showed significant increase in anti-tumor efficacy,with growth inhibition rate of 23.0%,34.4% and 56.3%,respectively. Necrosis and decrease of vessels in the tumor and morphological changes of endothelium were observed under light microscope in suramin group and DDP + Suramin group. Immunohistochemical staining of MVD and bFGF showed that Suramin group and DDP + Suramin group were significant lower than control group (P 0.01). The metastatic foci on lung surface were obviousy inhibited by suramin and suramin+DDP compared to DDP and the control group. Contracted to DDP,the expression of subcutaneous tumor MVD,bFGF and lung metastatic occurring rate were also obviously inhibited by suramin. The combined group showed great synergetic effect in decreaseing metastatic foci on lung surface. Conclusion Suramin can inhibit tumor angiogenesis in lung adencarcinoma and has strong inhibit effectory on both tumor growth and lung metastasis of adenocarcinoma transplanted in T739 mice.


I. INTRODUCTION. 1. The Role of Theory in Learning and Instruction. 2. Early Behaviorist Theories. 3. Gestalt Psychology: The Cognitive Perspective. II. MAJOR TRENDS. 4. Influences on Theory and Research. 5. The Human Brain. III. LEARNING PROCESS THEORIES. 6. B.F. Skinners Operant Conditioning. 7. Robert Gagnes Conditions of Learning. 8. Cognitive Perspectives I: The Processing of Information. 9. Cognitive Perspectives II: Metacognition and Problem Solving. IV. COGNITIVE DEVELOPMENT THEORIES. 10. Jean Piagets Cognitive Development Theory. 11. Lev S. Vygotskys Cultural-Historical Theory of Psychological Development. V. SOCIAL CONTEXT THEORIES. 12. Albert Banduras Social-Cognitive Learning Theory. 13. Cognitive Models and Theories of Academic Motivation. Epilogue. Glossary. Name Index. Subject Index.


Acute lymphoblastic leukemia (ALL) with high‐risk features has an inferior outcome. Factors influencing the treatment and outcome of pediatric ALL with high‐risk features in developing countries have not been well studied.


At its May 2018 meeting, the Commission approved $233.2 million in Senate Bill 1 (SB 1) Solutions for Congested Corridor Program (SCCP) funds for the San Mateo and Santa Clara US 101 Managed Lanes Corridor project. The project is comprised of two segments – the US 101 Managed Lanes project (PPNO 0658D), which includes $200 million in SB 1 SCCP funding; and the Silicon Valley Express Lanes – Phase 3 project (PPNO 2015E), which includes $33.2 million in SB 1 SCCP funding. The Silicon Valley Express Lanes – Phase 3 project received an allocation at the August 2018 Commission meeting and is scheduled to begin construction in December 2018.


To the Editor: Mimivirus is a giant, double-stranded DNA virus. Its 650-nm diameter and 1.2-Mb genome make it the largest known virus (1). In 2003, mimivirus was isolated from a water cooling tower in Bradford, UK, after a pneumonia outbreak and was reported to infect Acanthamoeba polyphaga amebae (2). Subsequently, a small number of additional isolates have been reported (3).


This paper proposes a generative account of the syntactic structure of get-passives in English and argues that they are best analyzed as ECM constructions with a silent null reflexive subject in the embedded passive small clause complement.As demonstrated,get patterns more like a lexical verb than an auxiliary.It assigns an external theta-role to the sentence subject,which is interpreted as the causer of the event described by the following VP,and selects a small clause as its complement,in which the embedded subject,being base-generated as the underlying object of a passive V,is a silent null reflexive,antecedently-bound by the matrix subject.On this analysis,the get clauses are not themselves passive,but merely contain passive clauses as complements.


Abstract : This report describes the work done to develop interface and support circuitry for additional PTF, ABC and RSAM modules and the use of a Z80 microprocessor in controlling the interconnection of these modules in various systems. In an attempt to increase the flexibility and range of applications, emphasis has been directed to architectural additions, modification of existing hardware, new algorithm development and new software development. Keywords: Charge coupled devices (CCD); Signal processing applications; CCD-based module; Microprocessor control; Flexible interconnections; Hardware modification; and Software control.


Disclosed is a clear channel assessment method, capable of increasing the carrier utilization rate. The method of the present invention comprises: performing, from an initial time slot, clear channel assessment on a first set of carriers; when the first set of carriers is idle at a current time slot, using the first set of carriers to transmit information at a next time slot of the current time slot; and when the first set of carriers is busy at the current time slot, continuously performing clear channel assessment on the first set of carriers at a next time slot until the current time slot becomes an end time slot. The present invention also provides a network node that is able to implement the method.


Department of Soil Ecology, Helmholtz Centre for Environmental Research – UFZ, Halle, Germany, German Centre for Integrative Biodiversity Research (iDiv) Halle-Jena-Leipzig, Leipzig, Germany, 3 Terrestrial Ecology, Institute of Zoology, University of Cologne, Cologne, Germany, 4 Key Laboratory of Agroecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha, China, Molecular Biology of the Rhizosphere, Crop


The multi-sensor array, such as the sound, light, infrared, vibration etc, is used to get the street lights environmental information. Combined with a variety of clock control strategy for control lamps, it can achieve the background information of perception, detection, identification, and collect the typical characteristics of an effective signal, to rationally determine the threshold value range in the circuit design and lay a solid foundation for the realization of intelligent control of lights. The joint acquisition streetlights background signal through a variety of sensors carried out in a typical experimental design and preparation, principles, introduction, experimental methods and experimental analysis of the results, not only can test the design of control circuit, but also optimize the choice of the sensor models to provide true comparative data. In order to facilitate in a real environment to detect and further identify goals, to achieve the typical information data fusion of specific objectives, the ultimate street intelligent control can be achieved. Experimental results show that the magnetic sensors and infrared sensors detect close proximity, so the model of sensor needs to be replaced or further improved design (such as the optimization of pre-level filtering and amplification circuit design). Acoustic sensors and vibration sensors to detect distance, can meet night lighting control at residents of the community as well as tourist attractions. But there are a lot of distances to meet the use demands of roads and high-speed traffic, the more optimal designs and experiments is need. In addition, a range problem of information synchronize data collection, background noise and a variety of information data crosstalk need to be solved in the joint acquisition experiments, which in the paper were discussed.


Exam stress has been a challenge in the life of many students. The race to achieve a good grade is more difficult with the increase in education standards and self-requirements. Although exam stress is persistent in all areas of education, we focus on understanding its effects in the field of Computer Science. Some factors that affect exam stress include differences in education systems, background knowledge, and gender stereotypes. These factors have been playing a crucial role in creating or increasing exam stress and affecting students' performance during exams. In this study, we aim to understand at what levels Computer Science students experience exam stress, the role of gender stereotypes, and their effects on Computer Science students during exams. We conducted our research using surveys and interviews to collect responses from students about their experiences and perspectives on exam stress and the role of gender. 26 students participated in the survey, with 12 females and 14 males. Similarly, 5 participants were interviewed, including 2 females and 3 males. The results indicate that students experience exam stress, and females tend to be more stressed about an exam than males. We also encountered some ambivalence in the results where on the one hand, there was no explicit gender bias. In contrast, on the other hand, there was a sense of stereotypic stress that was present. Lastly, we also learned some possible remedies to overcome exam stress and anxiety.


Abstract A simple and mild protocol for the palladium-catalyzed Suzuki reaction of aryl bromides and arylboronic acids is developed. The cross-coupling reactions can be performed at room temperature using 5.0 equiv. of Et3N as solvent and base without any ligands, and affording biaryl products in good yields. In addition, the chemoselecitive Suzuki reaction of bromo-N-methyliminodiacetic acid (MIDA) boronates with arylboronic acids can be achieved in this system, and various unsymmetrical terphenyls have been prepared in moderate yields by one-pot double Suzuki reactions. GRAPHICAL ABSTRACT


A power-free method is explored to perform mixing in a microchannel without any external active mechanisms such as pumps, valves, or external energies like electrostatic, or magnetic fields. The proposed mixing device is power-free in the sense that the surface tension is the only force that transports, merges, mixes, and stops the liquid. It is cost-effective that the channel has no sidewalls with the liquid being confined to flow between a bottom hydrophilic stripe and a top-covered hydrophobic substrate. Moreover, asymmetric staggered cavities (Stroock et al., Science, 2002, 295, 647) are optimally arranged on the bottom substrate of the channel to help mixing two different liquid species. It is most crucial to this power-free mixing device that two liquid species must be well mixed before the liquids are transported to exit the channel by the surface tension. Here it is found with a strong physical background that this can be achieved if the microchannel has the physical dimensions: 3~5 mum in height, 1.5-2 cm in length with a fixed width 100 mum, and the cavities have a depth comparable to the channel height


Due to limitations of power, computation capability and storage resources' wireless sensor networks are vulnerable to many attacks. The paper proposed a novel routing protocol algorithm for Wireless sensor network. The proposed routing protocol algorithm can adopt suitable routing technology for the nodes according to distance of nodes to the base station, density of nodes distribution and residual energy of nodes. Comparing the proposed routing protocol algorithm with other routing protocol algorithm through comprehensive analysis, the results show that the proposed routing protocol algorithm is secure and efficient for wireless sensor networks.


Hydrogen monitoring by the hydrogen patch probe (HPP) has been applied to a fluid catalytic cracker gas recovery system absorption tower in which gas feed entered about one-third of the way up from the bottom and lean oil entered the top. The HPP was installed near the gas feed area, which had shown the most severe hydrogen blistering and cracking. When 10 ppm of a water-soluble inhibitor was added, the hydrogen permeation rate dropped to approx. 2 jamp. Five days after inhibitor injection was stopped, the HPP showed a rapid increase in hydrogen activity, at which time inhibitor was added at 5 ppm, reducing activity to approx. 20 jamp. On the 18th day after installation of the HPP, an oil-soluble inhibitor was added, which reduced hydrogen rates to 2 jamp on the 50th day. Further testing led to a 5 jamp rate at 4 ppm of another water-soluble inhibitor. The HPP allowed the monitoring of a vessel that could not be monitored in another way. Other studies showing that hydrogen activity is a function of corrosion rate, metal thickness, and temperature were also performed.


Robotics provides an excellent medium for teaching and learning. In this book the authors show just how effective robotics can be when applied to education and the classroom.


DURING recent years great progress has been made both in this country and on the Continent in the treatment of malignant tumours by means of radium. To Wickham, Degrais and Dominici, of Paris, we owe our present knowledge of radium therapy. So long ago as the year 1904, Wickham and Degrais first commenced to treat superficial growths with any degree of success, though four years previously Danlos, also of Paris, had tried the effect of radium upon cancer. However, the greatest advance in the use of this agent for therapeutic purposes was inade by Dominici, who initiated the method of burying the tube containing the radium in the growth itself. Further, this same observer carried out an investigation into the microscopic changes which take place more especially in sarcomata, when exposed to the rays of radium. For some months I have been carrying out an investigation into the changes which take place in the cells of malignant growths, when exposed to the gamma.rays of radium. The procedure which I have adopted in this investigation is as follows: A small portion of the growth is removed before exposure to these rays for the purpose of comparison between the radiated and the nonradiated cancer cell. On removal of the tube of radium, which ia every case was embedded in the tumour for periods varying from fifteen to twenty-four hours, that part of the growth in actual contact with the tube of radium was excised. Further portions of the tumour were reinoved for microscopical examination at intervals of forty-eight houars to two months. The tissues submitted to the action of the gamma-rays when removed by the scalpel appeared to be completely insensitive, and it was not found necessary to make use of either general or local anasthesia in performing the operation. I have had personal experience of the anesthesia produced by the gamma-rays, for last July, as a result of handling radium daily over a period of two months, changes occurred in the skin of the forefinger and thumb of my right hand, which caused a temporary loss of tactile sensation, but marked sensibility to heat and cold.


Job satisfaction is the result of the way individuals experience work and their job post. It is connected to their attitude towards different aspects of their work, which may be positive or negative. However, the level of job satisfaction depends on a number of factors. Some of them can be controlled to improve job satisfaction. The higher the level of job satisfaction, the more efficient the individual becomes. In addition, job satisfaction impacts his or her satisfaction with life in general, thus reducing the possibility of stress occurring in the workplace. Special and rehabilitation pedagogy educators have many employment opportunities because they can work in various educational programs. However, different programs require different roles, responsibilities and work conditions, which may affect job satisfaction.
A total of 176 special and rehabilitation pedagogy educators working either in a special educational program, an adapted educational program with a lower educational standard or in a program involving adapted education and additional professional assistance (mobile service for special pedagogy) took part in the research. The results provided insight into the level of job satisfaction among special and rehabilitation pedagogy educators who are engaged in individual programs. No statistically significant differences were observed between the groups in terms of their job satisfaction, which was actually quite high. Another point of interest were the factors that have a negative influence on the job satisfaction of special and rehabilitation pedagogy educators working in individual programs. It transpired that all three groups had the same factors in common: respect from the head and co-workers, working conditions, and accomplishment at work. Special and rehabilitation pedagogy educators involved in adapted education and additional professional assistance listed another factor, i.e. reputation of the work. Based on theoretical background and research results we devised guidelines to help improve job satisfaction among special and rehabilitation pedagogy educators.


The invention relates to a preparation for treating allergic rhinitis. The preparation is prepared by pressing a quick release layer and a sustained-release layer into bilayer tablets and coating, wherein the quick release layer consists of the following components in percentage by mass: 1 to 10 percent of levocetirizine hydrochloride, 1 to 15 percent of disintegrating agent, 0.5 to 3 percent of lubricating agent, 0 to 8 percent of adhesive and the balance of filler; the sustained-release layer consists of the following components in percentage by mass: 20 to 30 percent of pseudoephedrine hydrochloride, 50 to 60 percent of sustained-release framework material, 0.5 to 3 percent of lubricating agent, 0 to 8 percent of adhesive and the balance of filler; and the mass ratio of the levocetirizine hydrochloride to the pseudoephedrine hydrochloride is 1:48. The sustained-release tablets for treating the allergic rhinitis have bright and clean surfaces, and the release behavior of the main medicine pseudoephedrine hydrochloride of the sustained-release tablets has high consistency with that of American marketed medicine cetirizine hydrochloride and pseudoephedrine hydrochloride sustained-release tablets through detection; and the dissolution rate of the main medicine levocetirizine hydrochloride of the sustained-release tablets in 30 minutes is over 90 percent, so that the sustained-release preparation for treating the allergic rhinitis has high bioavailability, a good absorption effect, comprehensive and effective clinical curative effects, small side effects and ideal safety.


Square tubes are primarily used in automotive structures to absorb energy in the event of an accident. The energy absorption capacity of these structural members depends on several parameters such as tube material, wall thickness, axial length, deformation modes, locking strain, crushing stress, etc. In this paper, the work presented is a continuation of research conducted on exploring the effects of the introduction of cellular core in tubular structures under axial compressive loading. Here, the crushing response of composite cellular core tube was numerically studied using ABAQUS/Explicit module. The energy absorbing characteristics such as deformation or collapsing modes, crushing/ reactive force, crushing stroke, and energy curves were discussed. The composite cellular core tube shows promise for improving the crashworthiness of automobiles.


There is an increasing concern in the energy sector about how to confront its growing water demand, in a global setting in which water is expected to become a scarcer good. Indeed, the increase in energy demand will require more water for cooling power plants, for growing biofuels, or for extracting and refining fuels. On the other hand, the intensive use of fossil fuels for energy contributes significantly to a climate change that will reduce in some countries water inflows and in most of them will make them more irregular, thus increasing the risk of water stress. This paper tries to assess the new water uses related to the different energy scenarios, and the relative weight that energy uses of water will have on different regions under each one. Results show that, although there should not be significant problems at the global level, a careless selection of energy technologies and management of water resources might create problems in some regions, such as Middle East, China, Latin America or some parts of Asia. The right economic signals should be devised to avoid these potential crises.


Friction material intended to equip a device employing friction in a liquid medium, comprising a mat of fibers impregnated with a thermosetting resin, wherein the fiber mat is comprised of fibers whose length is greater than or equal to 12 mm, and which are carded, topped and needled and wherein said friction material comprises a porosity greater than or equal to 30% by volume and less than or equal to 60% by volume, wherein said friction material comprises activated charcoal loads whose specific surface area is between 500 m / g and 2500 m / g, and the mass content in said friction material is greater than or equal to 5% by weight and less than or equal to 15% by weight.


The Cameron Highlands, an idyllic highland resort in Malaysia, are now being threatened by landslips and flash floods due to numerous development projects as well as intensive agricultural activities being associated with tourism. A study of the land use management factor (Cover and Management factor, C, and Support Practice factor, P) of the Universal Soil Loss Equation (USLE) has been undertaken, as this parameter reflects the land cover in the study area and its effect on soil erosion. Using remote sensing satellite imagery, the Ringlet area in the Cameron Highlands has been identified as having the highest erosion risk/loss based on the CP factor and this is confirmed by its highest ranking for residential and construction areas compared to other locations. The results of this study highlight the important land uses associated with erosion risk, and provide guidance to ensure that development is carried out to ensure a quality environment for the future.


Results: There was a lower rate of gestational diabetes mellitus with an odds ratio (OR) of 0.1, and 95% confidence interval (CI) of 0.01-0.4 in the teenage group. Apart from a lower mean gestational age at delivery, they had a higher rate of preterm labour at less than 37 weeks (OR = 2.0; 95% CI, 1.3-2.9) with a significantly higher rate of extremely preterm labour between 24 and 28 weeks (2.5; 0.7-8.4). The teenage group had a lower incidence of induction of labour (OR = 0.7; 95% CI, 0.5-0.8) but a higher rate of augmented labour (1.7; 1.4-2.1). They were more likely to achieve spontaneous vaginal delivery (OR = 3.9; 95% CI, 2.9-5.1), with a significantly lower risk of instrumental delivery (0.4; 0.2-0.5) and elective (0.1; 0.03-0.6) and emergency Caesarean section (0.3; 0.2-0.5). Babies of the teenage group had a lower mean birth weight, with more low-birth-weight babies (OR = 1.7; 95% CI, 1.2-2.4) and less macrosomic babies (0.2; 0.05-0.8). Despite more of their babies having low Apgar scores at 5 minutes (OR = 2.6; 95% CI, 0.9-7.4), the neonatal outcome was good.


Pronunciation is an essential skill that significantly affects the effectiveness of foreign language learning. However, the reality shows that incorrect pronunciation is still a big obstacle for Vietnamese students in general and students of the University of Transport and Communications, HCM city campus, in particular, in the process of learning English. Many students feel embarrassed when speaking English and have difficulty listening comprehension because of incorrect pronunciation. This article presents the research results on pronunciation errors of 100 non-language majored students at University and college at the University of Transport, HCM campus, analyzes the causes, and offers solutions to overcome the problem.


This section contains a list of reference article on empirical studies in theology that occur in the book on Empirical theology in texts and tables: qualitative, quantitative, and comparative perspectives . The theme of the third conference in Bangor was designed to display and to assess the strengths of empirical theology across the three domains of theoretical elaboration, qualitative methodologies and quantitative methodologies. It is the theme of the conference that has given rise to the title and to the structure of the present volume.Keywords: empirical theology; qualitative methodologies; quantitative methodologies; theoretical elaboration


In this study, lightweight aggregate was made from basalt stone powder sludge. Clay and glass powder were respectively added from 0 to 20 wt% and from 0 to 100 wt%. The glass powder helped to form glassy phase which trapped generating gas in the materials. CaCO₃ helping bloating process was added from 0 to 10 wt%. It was possible to produce lightweight aggregate at range from 1150℃ to 1200℃. The specimen was heated in furnace at 1100, 1150 and 1200℃ for 15 min, respectively, to sinter aggregates. Chemical composition of materials were determined, and characteristics were analyzed, including specific gravity, water absorption. Lightweight aggregate which was heated at 1200℃ had specific gravity of 0.53 g/㎤, water absorption of 3.08%, and this value satisfied KS L 8551 standard.


A computer‐based speech training system, the Indiana Speech Training Aid (ISTRA), has been shown to be clinically effective for improving the speech of hearing‐impaired and phonologically disordered individuals [Kewley‐Port et al., Clin. Ling. Phon. 5, 13–38 (1991)]. The potential value of speech recognition technology for the training of foreign‐accented speech, using an overall measure of speech quality as feedback, was assessed. Phonological errors in English spoken by two native Mandarin speakers were analyzed and several training targets selected. One consonant and one vowel contrast each were selected for training using ISTRA, and by a speech‐language pathologist (SLP). Pre‐ and posttraining tokens were rated for quality by a listener jury. Results showed significant improvement for both the ISTRA‐trained consonant /l/, and the SLP‐trained consonant /θ/. However, only one of the two vowel contrasts for each speaker improved significantly. ISTRA‐trained sounds which showed significant improvement did...


In the last ten years the German government has established several standards for data visualization for asset management and especially for pavement management. These standards improve communication between participants of the decision-making process. The required content as well as the structure and formats of the graphics are described in detail and published in advertisement. The most important standard visualizations are thematic maps, statistics and geo-statistical graphics, and strip maps. Specialized software has been developed for generating standard visualization of the input data used for asset management. This paper presents some visualization standards for asset management that are used for almost all management tasks in the Federal Republic of Germany. (a) For the covering entry of this conference, please see ITRD abstract no. E212095.


"The Presbyterian Church is indebted to the late Rev. A. L. Lindsley, D. D., pastor of the First Prebyterian Church, Portland, Oregon, for eighteen years, for opening mission work in Alaska."


Abstract Various new identities, recurrence relations, integral representations, connection and explicit formulas are established for the Bernoulli and Euler numbers and the values of Riemann's zeta function ζ(s). To do this, we explore properties of some Sheffer's sequences of polynomials related to the Kontorovich–Lebedev transform.


The present invention relates to a flooring material which is impact-resistant acid, flooring materials the following ingredients in a weight ratio of composition: diallyl phthalate 15 to 19 parts, 17 to 22 parts of a polyurethane, a bisphenol S type ring epoxy resin 17 to 18 parts, tricyclodecanyl acid ester having 6 to 10 parts, 5 to 8 parts tris iso-decyl acrylate, barium stearate 3 to 4 parts of n-butanol is from 1 to 2 parts . Floor materials prepared with good acid and alkali resistance and impact performance.


In the Dutch coastal waters more and more wind turbines on monopile foundations are built. An important design parameter is the first natural frequency of the wind turbine. The first natural frequency is dependent on environmental conditions and different soil conditions such as scour. This research gives a better insight into the sensitivities of these influences on the first natural frequencies. The first objective was to determine the sensitivity of different influences on the first natural frequencies in a full scale test environment. The first natural frequencies of four wind turbines (two protected against scour and two not protected against scour) in the Eneco Luchterduinen wind farm are constantly monitored and the natural frequencies are identified. It was found that only the water level has an identifiable influence on the identified first natural frequency and that the design natural frequencies and identified natural frequencies differ significantly. After the analysis from the full scale test different influences on the first natural frequency in a numerical computer model are investigated. The computer model predictions confirm that the water level has an identifiable effect and only small effects of backfilling of the scour hole on the first natural frequency are found. The third objective was to compare the sensitivity of different influences on the first natural frequency obtained from the computer model and from the full scale test. The effects of the water level are comparable. And the effect of backfill of the scour hole was found in the model but not in the full scale test. Therefore no conclusion is made on the effect of backfill nor on the presence of backfill. It was found that in order to mitigate the differences in first natural frequency of the test turbines and the model the soil should be modelled twenty times stiffer. The main influence on the first natural frequency of the offshore wind turbines in the Eneco Luchterduinen wind farm is the soil stiffness. The only other identifiable influence was the water level. Also in the design of the wind turbine the soil stiffness is underestimated significantly, implying overconservative designs.


This paper present a rail-to-rail single ended amplifier designed for driver applications requiring full range input and output swing with minimum distortion and noise. The amplifier drives an AC-coupled 270/spl Omega//100pF load to within 0.1 V of either rail for operation between 2.1 V and 5.5 V with less than 0.02% THD in the audio band. This was achieved with a high gain amplifier (126 db) and a quiescent current of 330 /spl mu/A. Operating at 3.3 V, it drives an AC-coupled 30/spl Omega//100pF load 2Vpp with 0.016% THD.


Multi-Agent System has been proved as an effective way to develop large-scale distributed system.Aiming at multi-user shared experimental environment for collaboration of virtual experiment system,a kind of collaborative working mechanism based on Multi-Agent has been designed to resolve the conflict in the virtual entities' operation.Cooperative Control Agent solved how to ensure consistency in the issue of the target entity when multiple users Agent access to a physical object at the same time.


The famous poets Bao Zhao and Li Bai have a lot of common in poem creation,for example: strong desire of keeping forging ahead;indignant feeling of unrecognized talents;moving chapter of caring people's suffering and women's unfortunate experience.Both of them can inherit the realistic tradition of folk song,regard the actual life of their times as the content,make content and form merge with each other and reach perfect unity.


In recent years,financial ecological environment of central China has been improved.However,it was detuned because of the lagged finance development,lower exportoriented economy,overflow policy,poor legal environment and missing of credit environment.In order to achieve a virtuous interaction of regional economy and its finance,and to promote the takeoff of central China,it is very important to build a harmonious finance ecological environment,improve the financial legal system,optimize the financial credit environment,standardize the behavior of the government,expand infrastructure construction and intermediary organizations.


Let $\mathbf{X} = ( X_1,X_2,\ldots,X_N )$ be a time series. That is a sequence random variable  indexed by the time $t=(1,2,\ldots,N)$, we suppose that the parameters of $\mathbf{X}$ are piecewise constant. In other words, it exists a subdivision $\tau=(\tau_1< \tau_2<\ldots < \tau_K )$ such that $ X_i$ is a family  of independent and identically distributed (i.i.d) random variables for $i \in (\tau_k,\tau_{k+1}] $, and $k = 0,1,\ldots,K$ where by convention $\tau_o=0$ and $\tau_{K+1}=N $. The preceding works such that (Bertrand, 2000) control the probability of false alarms for minimizing the  probability  of type I error  of change point analysis. The novelty in this work is to control the number of false alarms.  We give an bound of number of false alarms and the necessary condition for number of no detection. In other hand, we know the filtered derivative (Basseville \& Nikirov, 1993) depends the parameters such that the threshold and the window, we give in order to choose the optimal parameters. We compare the results of Filtered Derivative optimized parameters and the Penalized Square Error methods in particulary the adaptive method of (Lavielle \& Teyssi\`ere,  2006).


The new-Keynesian, Taylor rule theory of inflation determination relies on explosive dynamics. By raising interest rates in response to inflation, the Fed induces ever-larger inflation, unless inflation jumps to one particular value on each date. However, economics does not rule out explosive inflation, so inflation remains indeterminate. Attempts to fix this problem assume that the government will choose to blow up the economy if alternative equilibria emerge, by following policies we usually consider impossible. The Taylor rule is not identified without unrealistic assumptions. Thus, Taylor rule regressions do not show that the Fed moved from "passive" to "active" policy in 1980.


In this paper, we propose a method of trigger pulse generation to capture the image on time by making a synchronization between the x-ray generator and digital x-ray image acquisition system. we designed a wireless trigger pulse generation circuit to make a synchronization between x-ray generator and digital image acquisition system and analysis its performance. When it starts to detect a certain level of x-ray radiation or above from the air, this method starts to generate a ACQ_START signal to indicate the timing for image acquisition starting from digital image acquisition system. Hence, when it starts to detect under certain level of x-ray signal from the air, this method starts to generate a ACC_END signal to indicate the timing for image acquisition stop from digital image acquisition system. Image acquisition is activated only this time between ACQ_START and ACQ_END signal. By doing this wireless detecting of x-ray signal from remote, we can get more accurate timing for capturing the x-ray image and any type of x-ray generator can be connected to digital image acquisition system, regards of wired protocol. This makes easy installation. We could get 3.5 line pair / mm resolution at 20 mAs of x-ray level with resolution chart. This is same or better image comparing to conventional wired result.


Realism is a kind of termionlogy of artitic history,artistic comment and artisit theory. According to realism of drawing, specific showing of realism spirit in the plastic arts and the substance of realism spirit, this article hold a carefully workedout, in-depth analysis.


Forced expiratory volumes are reduced in chronic obstructive pulmonary disease (COPD), mainly as a result of in£ammatory andmorphological changes in the small airways (with a diameter52mm) and in the alveoli. However, it is di⁄cult to detect minor changes in small airways by spirometrymeasurements.To study the e¡ects on small airways of inhaled corticosteroids (ICS),19 stable COPD patients were investigated; 15 were evaluated by ventilation^ perfusion (VA/Q) relationships, assessed by the multiple inert gas elimination technique, and by di¡using capacity for carbonmonoxide (DLCO), assessed by the single breath technique.Measurementswere repeated after 2 months of budesonideinhalations (800 mg) twice daily.Before ICStreatment: meanforcedexpiratory volumein1sec (FEV1) as apercentage ofpredicted (% P)was 40?1 (+16?0)%,DLCO%Pwas 45?7 (+25?0)% and 6?0 (+6?4)% oftheventilationwasdirected athighVA/Qareas.ThemeanoftheVA/Q ratio for ventilation (V-mean) was 2?7 timeshigher thannormal. After 2 months of ICS: themeanof DLCO% Pincreasedby 8?6 (+19?4)%, and FEV1/vital capacitydecreasedby 6?9 (+11?3)%.Basalmorningand ACTH-stimulated S-cortisollevelswere signi¢cantlyreduced.AlltheVA/Q relationshipsremainedunchanged.In conclusion, a signi¢cant increase in di¡usion capacity for carbon monoxide levels after treatment with corticosteroid inhalations for 2 monthswas shown, but no signi¢cant improvementswere found in forced expiratory air£ow, lung volumes, orVA/Q relationships. c 2001Harcourt Publishers Ltd doi:10.1053/rmed.2001.1124, available online athttp://www.idealibrary.comon


Instrumental meat quality and fatty acid composition of lean muscle from beef steers offered grass silage alone or in combination with legume/cereal based wholecrop silage at two concentrate levels P C Kennedy, L E R Dawson, B W Moss, A Fearon, D J Kilpatrick Queens University, Belfast, United Kingdom, Agri-Food and Biosciences Institute, Hillsborough, United Kingdom, Agri-Food and Biosciences Institute, Belfast, United Kingdom Email: email@example.com


A spray group combustion model of an axispmnmtric laminar l i q u i d f u e l j e t has been developed t o e s t a b l i s h a s t r u c t u r a l c l a s s i f i c a t i o n of spray flame and t o a i d i n design of combustors. The model systematical ly p red ic t s flame/spray j e t configurations and aerothermochemical s t ruc tures of three pr inc ipa l group combustion modes; ex te rna l and i n t e r n a l group burning modes and s ing le droplet mode. Twenty-one se lec ted case s tud ies a r e made t o assess the flamr modal s e n s i t i v i t y on pr inc ipa l spray parameters and i n i t i a l conditions. Results a r e presented which reveal s ign i f ican t configurat ional var ia t ion and emphasize the necessi ty f o r accounting c o l l e c t i v e behavior i n the design of spray combustors.


A metal enclosure whose lid is covered by an array of metal pins is studied in this paper. The pins are able to realize a fictitious perfect magnetic conductor surface at the pin end, thus inhibiting cavity resonances and propagation of electromagnetic interferences in a well-defined frequency band. This paper proposes an analytical model for predicting the behavior of the cavity, and thus for estimating the bandgap limits. The method is based on the planar cavity formulation, and it analytically embeds the pin-to-bottom-wall capacitance. The obtained cavity response agrees well with the simulated models of various cavity and pin dimensions. Moreover, the method is validated experimentally based on a manufactured cavity. Although some residual errors due to the difficulties in a precise calibration are present, the experimental results validate the proposed analytical model.


We have investigated a situation where two mesoscopic normal metal wires at different temperatures are separated by a distance much less than the typical thermal photon wavelengths (∼ 1 cm at sub‐Kelvin temperatures), corresponding to photon coupling by virtual, evanescent modes. Experimental results are shown for samples, where the phonon conduction has been removed by using suspended nanostructures, at sub‐Kelvin temperatures using SINIS‐thermometry. The expected evanescent photonic heat conductance is estimated using a simple parallel plate geometry.


The global economy is growing competitive, yet poverty and illiteracy prevail in rural Guatemala where indigenous cultures fight extinction. Peasants struggle for freedom from a system of corrupt law that has bound them to practices that do not celebrate their own traditions and culture. The place in the landscape itself bespeaks intensity, of color, of weather and of climate, that requires a sensitive built approach. Locals can exploit their existing materials and methodologies to arrive at more sensible strategies, relating back to native practices of weaving, harvesting, following sun movement, and gathering in communal workgroups. Tulan, a non-profit organization working to educate indigenous adults in the rural areas, has limited funding but is in need of an insightful, meaningful space to strengthen their mission. This thesis proposes strategies they can use to establish building workshops for their own students to come together and fabricate the new building. Through empowerment and education in a new headquarters for indigenous-run Tulan, their own cultural colors can shine through, weaving new patterns across Guatemala. SUMARIO


BACKGROUND
Haemodialysis remains the most common modality of renal replacement therapy. National and international guidelines continue to promote arteriovenous fistulas or grafts as the preferred vascular access for haemodialysis, given the increased risks associated with use of central venous catheters (CVCs). Our renal centre pursues a 'fistula first' culture and uses root cause analysis and a patient safety incident based approach to meet the recommended standards of minimal CVC use in dialysis patients.

METHODS
We undertook a retrospective observational review looking at patterns of CVC use amongst our patients to identify themes and changes over time. Using data collected over a 5 year period, we examined 100 patient safety incidents involving CVC use in planned haemodialysis patients. We used a contributory factors framework to identify systemic contributors to each incident.

RESULTS
During the study period our centre achieved the national standard of at least 60% of incident dialysis patients commencing planned haemodialysis via arteriovenous access. About 26% of cases of CVC use in incident dialysis patients were deemed potentially avoidable. The most common contributory factor identified in these cases was poor communication.

CONCLUSIONS
Using a root cause analysis based methodology to examine CVC use in haemodialysis is a novel approach to quality improvement in this area. Our methodology can be used as a framework by other centres to optimise the provision of safe, effective, and timely vascular access for dialysis, with multiple benefits for both renal services and individual patients.


Despite the widespread adoption of process management systems (PrMS) by industry, there exist numerous processes that cannot be adequately supported by PrMS so far. A common characteristic of these processes, which is usually neglected by traditional activity-centric PrMS, is the role of data as driver for process modeling and enactment. To overcome the limitations caused by missing integration of data and process, several data-centric process management approaches have emerged. A popular one is the Case Handling (CH) paradigm. However, previous case studies pointed out that, although it targets some of the limitations from activity-centric PrMS, the integration of processes and data supported by CH is still unsatisfactory. In this paper, we present the lessons learned from previous case studies and discuss the limitations of CH. We then present the PHILharmonicFlows framework, which enhances the power of data-centric approaches such as CH by enforcing a well-defined modeling methodology governing the object-centric specification and execution of processes and based on a formal operational semantics.


In recent years, nonlocal strain gradient theory (NSGT) has been widely applied by researchers for the analysis of nanostructures. In this theory, the appropriate selection of small‐scale parameters and the type of high‐order boundary conditions is of great importance. In the current paper, free vibrations of carbon nanotubes are studied using a nonlocal strain gradient Timoshenko beam model, and the small‐scale parameters are calibrated based on the molecular dynamics (MD) results. The calibration process is conducted by defining an optimization problem, and the genetic algorithm is applied for obtaining the best values of the small‐scale parameters. The governing equations are derived based on Hamilton's principle and solved analytically using the modified Fourier series method. The variational consistent high‐order boundary conditions are obtained applying the weighted residual approach. The small‐scale parameters are calibrated for the first three natural frequencies considering two different boundary conditions. Moreover, the type of high‐order boundary conditions that is more consistent with the MD results is determined. The outcomes of this paper provide an appropriate reference for researchers who are using the NSGT for the analysis of micro/nanobeams.


The effects of a contextual factor, i.e., task instructions, on performance on and reactions to an Intellegent Tutoring System (ITS) training Remote Manipulator System (RMS) tasks were examined. The results supported the first prediction that task instructions could be used to successfully induce a mastery versus an achievement orientation. Previous research suggests that a mastery orientation can result in beneficial effects on learning and performance of complex tasks. Furthermore, the results supported the second prediction that a mastery orientation would have beneficial effects on learning and performance as well as affective and cognitive reactions to the ITS tasks. Moreover, the results indicated that a mastery orientation was especially beneficial for the more complex ITS tasks and later in task practice, i.e., when a task was performed for the second time. A mastery orientation is posited to have its beneficial effects by focusing more effort and attention on task performance. Conclusions are drawn with some caution due to the small number of subjects, although the results for these subjects were consistent across multiple trials and multiple measures of performance. ITS designers are urged to consider contextual factors such as task instructions and feedback in terms of their potential to induce a mastery versus an achievement orientation.


The objective of research is to find out historical values of Cetho Temple containing character content in local culture and tradition that can be used as the source and material of character education in school. This study was conducted in exploratory manner, emphasizing on: 1) character values in historical background of Cetho temple, 2) character values in physical culture of Cetho Temple, and 3) character values in local tradition and culture of Cetho Hamlet people as the effect of Cetho Temple's existence. This was descriptive qualitative research in nature with naturalistic and exploratory approaches. Techniques of collecting data were observation, in-depth interview, archive study, historical analysis, and FGD. Data was analysed by using content analysis, analyzing the character content of Cetho Temple's historical values that can be the source and material of local culture-based education in school. The results of research showed that: (1) character values in Cetho Temple's historical background were: developing self-potency, developing work ethos and learning, having openness, having self-control, having and developing tolerance, believing in the existence of the One and Only God and always obeying His tenet, and obeying the religious tenet. (2) Character values contained in physical culture of Cetho Temple were: believing in the existence of the One and Only God and always obeying His tenet, obeying religious tenet, having and developing tolerance attitude, growing honesty, having commonness and mutual cooperation, having responsibility, having self-control, and having respect to each other. (3) Character values contained in local tradition and culture of Cetho Hamlet people as the effect of Cetho Temple's existence were: believing in the existence of the One and Only God and always obeying His tenet, having the feeling of responsibility, having commonness and mutual cooperation (gotong royong), obeying religious tenet, and having shy feeling.


Purpose – The aim of the paper is to test empirically the resources dependence theory on the Polish capital market through the analysis of interlocking directorates of publicly listed companies. Design/Methodology/approach – The social network analysis and statistical analysis were applied. Results – The resources dependence theory was only partially supported pointing out its constraints related to the omission of the costs and benefits analysis of interlocking directorates. Originality/value – This is a first attempt to analyze the aforementioned issues on the Polish capital market. keywords: intelocking directorates, board size, degree, resources dependence theory


The upper stream region of the Yellow River is rich hydro energy with a predominant condition for development. In the system reform, the Watershed Corporation will be reserved in order to make more significant economic benefit and speed up the development of hydropower in the upper region of the Yellow River.


We conducted a systematic review and summarized the outcomes of single-case research design studies conducted in the last decade that have implemented peer-mediated interventions (PMI) to address the social competence needs of children with autism spectrum disorder (ASD) younger than 8 years of age. Eighteen studies with 53 children with ASD were included. Data from those studies were extracted independently by two coders and coded for characteristics of children with ASD, characteristics of peers, characteristics of the intervention, risk of bias, and success estimate. Findings suggest that PMI are effective for increasing interactions between children with ASD and peers but may not be as effective for increasing initiations made by children with ASD or increasing responses made by children with ASD to peers' initiations. Researchers should prioritize conducting studies that seek to promote positive interactions initiated by children with ASD, possibly by modifying PMI to include preferred stimuli identified through systematic assessments.


With the development of information technology,network environment has become one of the important environments for learners.Cooperative learning based on network environment can stimulate learner's motivation,eliminate the feeling of loneliness,benefit the cultivation of cooperative and creative abilities among learners,increase cooperative consciousness and enhance learning efficiency.Beginning with cooperative learning concepts,in the paper,four essential elements about cooperative learning are introduced,and analyzed are also several models of cooperative learning.Finally explored are teaching strategies and practice of cooperative learning based on network environment.


Metacognition refers to individual's cognition about its' own cognitive process.Great deals of findings have been made concerning the relationship between the metacogniton and strategy selection that is always the metacogniton influences the strategy selection when the research first emerged in 1980s.The present review summarized the new findings about this domain in the fields such as the learning and memory,problem solving,and strategy instruction based on the nearest decade relevant researches at home and abroad.The authors looks forward to breakthrough on the four aspects which should be concluded the regulative use in high level,strategies in the basic memory and instruction,deep operation mechanism,and the new technique used to the research in the future.


Cocoon spinning was analysed, using video recording and playback, in eighteen Nearctic black fly species, comparing nine Simulium species, six Eusimulium species, Stegopterna mutata, Cnephia dacotensis and Prosimulium mixtum. Fourteen behavioural characters were revealed that produced twenty‐two equally parsimonious trees (CI = 0.93, RI = 0.96). Another tree was constructed on the basis of five characters relating to the cocoon structure (end‐product characters). The goal of the study was to determine whether characters relating to behavioural components of black fly cocoon spinning or those based on end‐products of the behaviour are superior for revealing phylogenetic relationships. This was accomplished by comparing both data sets to a phylogeny constructed with the use of cytological and morphological characters. If taxa are grouped according to end‐products (the cocoons) there are some spurious groupings. The behavioural analysis only required one extra step to duplicate the morphological and cytological tree. In the case of black flies, it is more informative to use characters resulting from the analysis of the cocoon spinning behaviour than cocoon morphology.


The room temperature ferromagnetic resonance (FMR) absorption at 8.9–11.2 GHz in two planar hexagonal ferrites, Zn2Y and MnZnY, has been found to exhibit strong nonlinear behavior at low power levels corresponding to microwave field amplitudes on the order of 10 mOe. For somewhat larger amplitudes, 20–50 mOe, the asymmetric resonance curves show pronounced foldover effects. With increasing static field, the absorption increases gradually to a steep cutoff at a field several hundred Oe above the position of the low power FMR. With decreasing field, a sharp spike occurs coincident with the high field tail of the low power FMR line, followed by a gradual decrease which tracks the upsweep absorption. The detailed shapes of these curves depend strongly on sweep rate. Steady‐state absorption curves at the highest powers employed, with 350 mW incident power and a microwave field amplitude of 58 mOe, result only for very slow sweep rates of 20 Oe/min or less.


An original spectral-bin cloud scheme is implemented in the MultiScale Simulator for the Geoenvironment (MSSG), which is an atmosphereocean coupled model designed for seamless weather and climate simulations. The spectral-bin scheme is based on an Eulerian-in-radius discretization scheme and, therefore, able to deal with the size of cloud droplet explicitly without drastic parameterizations. In this study, we perform three-dimensional simulations of turbulent clouds with and without considering the effect of turbulent collision growth of cloud droplets under different aerosol circumstances. Preliminary results show that the turbulent collisions have significant impact on cloud development and that the impact is strongly influenced by the aerosol circumstance.


Cube attacks are an important type of key recovery attacks against nonlinear feedback shift register (NFSR)-based cryptosystems. The key step in cube attacks closely related to key recovery is recovering superpolies. However, in the previous cube attacks including original, division property based and correlation cube attacks, the algebraic normal form of superpolies could hardly be shown to be exact due to an unavoidable failure probability or a requirement of large time complexity. In this study, the authors propose an algebraic method aiming at recovering the exact algebraic normal forms of superpolies practically. The proposed method is developed based on the degree of evaluation method proposed by Liu in Crypto 2017. As an illustration, the authors apply the proposed method to Trivium. As a result, they recover the algebraic normal forms of some superpolies for the 818-, 835-, 837- and 838-round Trivium. Based on these superpolies, the authors could mount key-recovery attacks on 818-, 835-, 837- and 838-round Trivium with the worst complexity slightly lower than a brute-force attack. Besides, for the cube proposed by Liu in Crypto 2017 as a zero-sum distinguisher for the 838-round Trivium, it is proved that its superpoly is not zero-constant. Hopefully, the proposed method would provide some new insights on cube attacks against NFSR-based ciphers.


As a basic course for tourist major,the Travel Agency Management is quite practical.Accordingly,the course should be aimed at cultivating the students' comprehensive ability,take the sale management as the core to restructure the system of the course and adopt the opening and research-oriented teaching style.


Winding device (1) for a fitting all steel (2) on a cylinder (3), with a frame (5), in which there are housed adjustably arm winding (4) by a guide device (11 ) with a guide carriage (13) and a guide rail (12) mounted fixedly in the direction of an axis of rotation (6) of a cylinder (3) to be coated with lining all steel (2), with a installation force measurement (21) for measuring a force acting on the arm winding (4) during the winding process, being arranged the measuring force (21) between the guide means (11) and winding arm (4).


Steganography is a technique for publicly transmitting secret information through a cover. Most of the existing steganography algorithms are based on modifying the cover image, generating a stego image that is very similar to the cover image but has different pixel values, or establishing a mapping relationship between the stego image and the secret message. Attackers will discover the existence of secret communications from these modifications or differences. In order to solve this problem, we propose a steganography algorithm ISTNet based on image style transfer, which can convert a cover image into another stego image with a completely different style. We have improved the decoder so that the secret image features can be fused with style features in a variety of sizes to improve the accuracy of secret image extraction. The algorithm has the functions of image steganography and image style transfer at the same time, and the images it generates are both stego images and stylized images. Attackers will pay more attention to the style transfer side of the algorithm, but it is difficult to find the steganography side. Experiments show that our algorithm effectively increases the steganography capacity from 0.06 bpp to 8 bpp, and the generated stylized images are not significantly different from the stylized images on the Internet.


To decrease the environmental degradation due to increasing amount of municipal solid waste the Ecology National Project was implemented in Russia. Its main goal is to increase recycling and liquidate all unauthorized landfills within the urban borders. While the key objective of the project is to ensure ecological improvement and to amend environmental situation in Russia its public acceptability and awareness is under question, especially in rural communities. The paper analyses rural waste management reform in small rural town in region (Sverdlovskay oblast). The main focus is on peoples' knowledge, acceptability and perceptions of the reform and its components, especially separate waste collection.


A health management system based on expert systems is designed for flight control system's fault diagnosis.The fault tree method and expert's experience are used to solve the key tasks in the design process,and the software prototype of the system has been designed by the object oriented programming.The results show that the system designed has the advantages of fast computing and high diagnosis precision.


Phase change materials (PCMs) are energy storage materials which can be used for maintaining a controlled thermal environment for various applications in earth and space. PCMs are used in advanced technologies in aerospace cooling applications like heat exchangers and heat pipes for re-entry vehicles and spacecraft. Paraffin is a phase change material (PCM) commonly used for energy storage-related applications. Paraffin wax exhibits slow thermal response due to low thermal conductivity value (~0.2 W/m K for most paraffin waxes). In the present work, an attempt is made to fabricate a composite PCM using graphite powder. Such a composite material has enhanced thermal conductivity along with reduced melting period which are desirable properties of a PCM during solid to liquid phase change process. The reduction in melting period is indicated by the difference in change in temperature measured by the thermocouples during a specified time. The temperature variation and solid-liquid interface formation during the melting process are experimentally studied. The results showed that composite graphite powder with paraffin can improve the total phase transition time.


Objective To study the regression relation between the hand length, the metacarpal length, the fingers length and the body height so as to provide scientific basic evidences for anthropolgy and forensic medicine study. Methods A methodology and a standard of anthrology were used to measure the hand length, the metacarpal length, the fingers length and the body height in 410 adults (male 201, female 209) of Zhuang nationality in Guangxi. The original data were analysed by medical statistics and regression analysis. Results The mean value of the hand length, the metacarpal length, the fingers length, and the body height were calculated out. The regression equation of estimated body height were obtained. Conclusion The hand length, the metacarpal length, the fingers length have high correlation with the body height. The regression equations can be used to estimate the body height in adults of Zhuang nationality.


...........................................................................................................................v List of Figures ..................................................................................................................x List of Tables ...................................................................................................................xii Chapter 1: Overview of Antimicrobials ...........................................................................1 Background ................................................................................................................1 History of Antimicrobials ...................................................................................1 Early and Present Uses of Silver as an Antimicrobial ........................................2 Silver Resistance in Bacteria ..............................................................................3 Antimicrobial Peptides Used as an Antimicrobial Agent ..................................4 Mechanism of Action of Cationic Antimicrobial Peptides ................................5 Antimicrobial Peptides Derived from Venoms and Toxins. ..............................6 Cationic Antimicrobial Peptide Decoralin. ........................................................6 Cationic Antimicrobial Peptide AP3 ..................................................................7 Introduction of Synergy as a Solution to Antibiotic Resistant Bacteria. ............7 Chapter 2: Characterization and Antimicrobial Activity of Amphiphilic Peptide AP3 and Derivative Sequences ........................................................................................1


The article traces the role of reflection in teacher education and explores the issue of the necessity of creating a system of developing student teachers reflective skills in the process of their university studies. The importance of reflection in linking theoretical knowledge with teaching and learning practices is emphasized. The model of guided reflection employed at the Department of Foreign Philology at H.S. Skovoroda Kharkiv National Pedagogical University is described in detail and examined through different research methods, including qualitative and quantitative analysis of various documents (questionnaires, observation charts, reflective essays etc.) and interviews with participant focus groups. The article presents samples of activities used in pedagogy and methodology classes, and observations of student teachers' behaviours while performing them. Some information about students' perception of the model steps is also provided. The collected data prove that student teachers manage to get accustomed to continuous reflection and, thanks to gradual transition from communal reflective activities to pair work and individual assignments as well as constant and sufficient scaffolding, interaction with the 'knowledgeable other' feel more confident, are getting aware of the benefits of reflection, and are developing skills of reflective practitioners, which are crucial for their further professional and personal growth.


Yes‐associated protein (YAP) and transcriptional co‐activator with PDZ‐binding motif (TAZ), the main effectors of the Hippo pathway, are emerging as important players in cancer biology and therapy response. The intracellular localization of YAP/TAZ is a key determinant in the regulation of their activity and their roles in signal transduction. This is particularly relevant for cancer: Aberrant nuclear localization of YAP and TAZ has been observed in numerous human cancers and may therefore represent an attractive target for cancer therapy. In this review, we describe the mechanisms that regulate the nucleo‐cytoplasmic shuttling of YAP/TAZ and their implications for cancer, and discuss how the new insights about this process may pave the way for novel therapeutic strategies.


This paper discusses different drive control methods of mining electric locomotive, presents a novel H∞ robust drive control strategy for a mining electric locomotive. Research work is done under different conditions namely variable battery voltage and variable load rotational inertia separately. A comparison between conventional PID control method and H∞ robust control method is done when they are applied to the above mentioned conditions. Under the drive condition, simulations results both indicate that PID controller and H∞ robust controller give good results. However, the H∞ robust controller gives a faster response and a better stability. Moreover, H∞ robust control follows the given current faster and more smoothly than by PID control and improve the drive range of mining electric locomotive.


Stochastic integer programming is a suitable tool for modeling hierarchical decision situations with combinatorial features. In continuation of our work on the design and analysis of heuristics for such problems, we now try to find optimal solutions. Dynamic programming techniques can be used to exploit the structure of two-stage scheduling, bin packing and multiknapsack problems. Numerical results for small instances of these problems are presented.