With the development of research, asymmetric winding motors (AWM) have been found taking advantage of lower cogging torque and higher torque density in some cases. In this paper, excellent characteristics of fractional slot motor with asymmetric concentrated winding are revealed by combining theoretical derivation and simulation computation. In addition, some correlation coefficients which represent the adverse effects of AWM are introduced, and provide references for the comprehensive design of AWM. Moreover, the 36-pole three-phase permanent magnet synchronous motor(PMSM) is taken as an example to compare the design of AWM and conventional motor. The feasibility of AWM scheme and its advantages in cogging torque and torque density are verified by the finite element modeling.


Non-pigmented methanol-dependent bacteria have been isolated in pure culture from a wide variety of natural sources. They are capable of growing only on methanol among many carbon sources tested, and showed no growth on ordinary nutrient media. These bacteria were identified as a new species, Methanomonas methylovora. The organisms are gram-negative, non- sporeforming rods, 0.4 to 0.7μ by 1.0 to 4.0μ in size, having a single polar flagellum. GC content of DNA is 51.2 to 53.6%. Some of them required a relatively high concentration of thiamine as an essential factor for cell growth, and produced an intracellular yellow pigment on methanol-containing agar medium.


: This paper is concerned with bounded real criterion for linear neutral delay systems. Two new delay-dependent bounded real lemmas (BRLs) are obtained in this paper, in which, Lyapunov theory is used to derive the first delay-dependent representation for BRL. Using a descriptor model transformation of the system and a new Lyapunov-Krasovskii functional, a less conservative bounded real lemma is obtained compared to that of the first BRL. Then sufficient conditions for the system to possess an H ∞ -norm less than a prescribed level, is given in terms of a linear matrix inequality (LMI). The significant advantage of the derived bounded real lemmas is their efficiency in designing H ∞ controller for the closed-loop neutral systems when delayed term coefficients depend on the controller parameters. Numerical examples are given which illustrate the effectiveness of our proposed BRLs.


A new multiple feature fusion based latent semantic indexing (LSI-MFF) method has been presented to achieve improved image retrieval performance. The LSI-MFF method extracts different physical features, which come from not the whole image but its main objects, and constructs a multi-modal semantic space, each dimension of which represents a different feature component of the image. LSI-MFF can discover the latent relations among the images which are actually similar in semantic. Furthermore, semantic relevance feedback (SRF) information from the users, which implies "what the users choose is the best", is also integrated into LSI-MFF method to improve the feedback performance of the system. Experiment results demonstrate the good robustness of LSI-MFF. The prototype system VAST (visual & semantic image search system) based on LSI-MFF has shown that LSI-MFF has superior performance and is especially suitable for mass image database such as web environment.


The first part of this paper consists in a comparison between Rosmini's gnoseological perspective and Brentano's one, starting from a passage in which the latter discusses the position of the first. The second part of the paper outlines the position of other Italian philosophers of the early twentieth century, who very early compared Rosmini's ideology with the gnoseological realism of Brentano and his school.  Some of them, such as De Sarlo, developed this comparison in the empirical-perceptive direction and in line with Brentano's descriptive psychology; others, such as   Capone Braga, followed the intuitive-ideal-eidetic line, in greater accord with Husserl's early phenomenology.


1. The telescope conjecture and Bousfield localization 4 1.1. Telescopes 4 1.2. Bousfield localization and Bousfield classes 6 1.3. The telescope conjecture 8 1.4. Some other open questions 9 2. Some variants of the Adams spectral sequence 10 2.1. The classical Adams spectral sequence 11 2.2. The Adams-Novikov spectral sequence 12 2.3. The localized Adams spectral sequence 15 2.4. The Thomified Eilenberg-Moore spectral sequence 19 2.5. Hopf algebras and localized Ext groups 23 3. The spectra y(n) and Y (n) 26 3.1. The EHP sequence and some Thom spectra 26 3.2. The homotopy of Lny(n) and Y (n) 30 3.3. The triple loop space 34 4. Properties of ΩS n 36 4.1. The Snaith splitting 36 4.2. Ordinary homology 37 4.3. Morava K-theory 41 4.4. The computation of Y (n)∗(Ω S n ) via the EilenbergMoore spectral sequence 46 5. Toward a proof of the differentials conjecture 50 5.1. The E2-term of the localized Thomified Eilenberg-Moore spectral sequence 50 5.2. Short differentials 57 5.3. Excluding spurious differentials 62


A discussion is given of the relations which exist among vibrational matrix elements for diatomic molecules represented as Morse oscillators. This is done according to the wave function approximation of Trischka and Salwen. It is shown how the matrix element of the dipole moment Mvi′ is related to the matrix elements M0i where v′—v≤i≤v′+v with v′>v. This relation is examined for the case of the 1–2 band of HCl. It is also shown how the matrix element M01 for DCl can be related to the matrix elements of HCl. Finally, the influence of the vibration‐rotation interaction is incorporated in the wave function approximation. In an example, it is shown that the matrix element {M0,Ji,J+1 can be expressed in terms of the set of matrix elements{M0,0i,1},i=0,1,··· .


We propose a new object decomposition method, called DMBRs, to improve the performance of spatial query processing. This method is suitable for complex spatial objects in real-world geographic applications. The basic idea is that a polygon is recursively divided into two subpolygons by splitting its MBR until a given constraint is satisfied. To increase the efficiency of the DMBRs method, an extension of an existing spatial indexing structure is presented. Since this new structure can prune a number of false hits quickly, the performance of spatial query processing can be improved. The proposed method is compared with traditional decomposition methods by an analytical study. This comparison shows that our decomposition method outperforms the traditional decomposition methods.


Background This meta-analysis aimed to evaluate the incidence of tumor recurrence, postoperative myasthenia gravis, postoperative complications, and overall survival after limited versus total thymectomy for Masaoka stage I and II thymoma. Methods A systematic search of the literature was conducted using the PubMed, Embase, MEDLINE, and Cochrane databases to identify relevant studies that compared limited and total thymectomy in Masaoka stage I–II patients. The quality of the included observational studies was assessed using the Newcastle-Ottawa Scale. The results of the meta-analysis were expressed as log-transformed odds ratios (log ORs), with 95% confidence intervals (CIs). Results Seven observational studies with a total of 2,310 patients were included in the meta-analysis. There was an overall non-significant difference in favor of total thymectomy in terms of tumor recurrence (pooled log OR, 0.40; 95% CI, -0.07 to 0.87; p=0.10; I2=0%) and postoperative myasthenia gravis (pooled log OR, 0.12; 95% CI, -1.08 to 1.32; p=0.85; I2=22.6%). However, an overall non-significant difference was found in favor of limited thymectomy with respect to postoperative complications (pooled log OR, -0.21; 95% CI, -1.08 to 0.66; p=0.64; I2=36.1%) and overall survival (pooled log OR, -0.01; 95% CI, -0.68 to 0.66; p=0.98; I2=47.8%). Conclusion Based on the results of this systematic review and meta-analysis, limited thymectomy as a treatment for stage I and II thymoma shows similar oncologic outcomes to total thymectomy.


Despite the success of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines, there remains a need for more prevention and treatment options for individuals remaining at risk of coronavirus disease 2019 (COVID-19). Monoclonal antibodies (mAbs) against the viral spike protein have potential to both prevent and treat COVID-19 and reduce the risk of severe disease and death. Here, we describe AZD7442, a combination of two mAbs, AZD8895 (tixagevimab) and AZD1061 (cilgavimab), that simultaneously bind to distinct, nonoverlapping epitopes on the spike protein receptor binding domain to neutralize SARS-CoV-2. Initially isolated from individuals with prior SARS-CoV-2 infection, the two mAbs were designed to extend their half-lives and reduce effector functions. The AZD7442 mAbs individually prevent the spike protein from binding to angiotensin-converting enzyme 2 receptor, blocking virus cell entry, and neutralize all tested SARS-CoV-2 variants of concern. In a nonhuman primate model of SARS-CoV-2 infection, prophylactic AZD7442 administration prevented infection, whereas therapeutic administration accelerated virus clearance from the lung. In an ongoing phase 1 study in healthy participants (NCT04507256), a 300-mg intramuscular injection of AZD7442 provided SARS-CoV-2 serum geometric mean neutralizing titers greater than 10-fold above those of convalescent serum for at least 3 months, which remained threefold above those of convalescent serum at 9 months after AZD7442 administration. About 1 to 2% of serum AZD7442 was detected in nasal mucosa, a site of SARS-CoV-2 infection. Extrapolation of the time course of serum AZD7442 concentration suggests AZD7442 may provide up to 12 months of protection and benefit individuals at high-risk of COVID-19. Description AZD7442 neutralizes SARS-CoV-2, has prophylactic and therapeutic efficacy in NHPs, and is projected to contribute to long-term human protection. Long-lasting antibodies Although monoclonal antibody therapeutics have considerably improved outcomes for individuals with COVID-19, their utility as a prophylactic intervention is restricted by the emergence of variants of concern (VOCs) and by short half-lives. To address this, Loo et al. evaluated a pair of antibodies, collectively termed AZD7442, which bind to two distinct epitopes on the receptor binding domain of the SARS-CoV-2 spike protein and have been modified to have an extended half-life. The antibody combination protected nonhuman primates from infection with SARS-CoV-2 when administered prophylactically or therapeutically. The antibodies were also resistant to all tested VOC, including the delta variant. Last, the authors showed that AZD7442 administration to healthy adults resulted in neutralizing antibody titers that were projected to confer long-term protection.


Demand-side management is an important method to improve the stability of power consumption and the reliability of power grid. In Energy Internet, the power supplier can obtain more detailed data about users' behaviour with numerous smart devices and advanced information network. Here, the utility function of power supplier is established by using the utility function of different users at different times, explicitly taking into account the economic operation's impact. The authors propose a Stackelberg game model to formulate the gaming process between users and power supplier. The authors convert the model into a convex problem to maximum power supplier's benefit, and then calculate the corresponding optimal time-of-use prices, and optimal economic operation power. The simulation results show that the model is effective and has a better result than the traditional profit-only model and non-time-of-use electricity pricing model.


Design pattern describes a problem which occurs once and again during the process of software development,and then the solution to that problem is described.Design pattern brings convenience to software reuse.In embedded communication software de-velopment,design pattern is applied to improve the quality of software.In addition to that,a bridge between embedded research and software development is established.A software design pattern which is widely used in embedded communication is brought forward.This pattern is described formally in detail,including its intent,motivation,applicability,structure and consequences,etc.Then an example is given to explain the consequences of this pattern.


ABSTRACT This study attempts to show how Doctorow's Ragtime draws a realistic and precise picture of a world entering the mechanical era and the consequential effects on the art and artists of the age. In such an era wherein everything is multiplied, reproduced, and publicized, the nature of art, artist, and audience are being modified as rapidly as the ethos of era. This study focuses mainly on four artists, who are among the novel's main characters, and draws on their diverse reactions to and decisions about reproduction. Some characters tend to be enthusiastic about these abrupt modifications and the subsequent publicity the modifications bring to art—hence they readily join this current. Meanwhile, some other characters resist the changes and crave for the traditional art and aura. And there are some who severely resist at first, but before long, they get melted in the pot of new culture and art.


The recent increase in credit card fraud is rapidly has caused huge monetary losses for individuals and financial institutions. Most credit card frauds are conducted online by illegally obtaining payment credentials through data breaches, phishing, or scamming. Many solutions have been suggested to address the credit card fraud problem for online transactions. However, the high-class imbalance is the major challenge that faces the existing solutions to construct an effective detection model. Most of the existing techniques used for class imbalance overestimate the distribution of the minority class, resulting in highly overlapped or noisy and unrepresentative features, which cause either overfitting or imprecise learning. In this study, a credit card fraud detection model (CCFDM) is proposed based on ensemble learning and a generative adversarial network (GAN) assisted by Ensemble Synthesized Minority Oversampling techniques (ESMOTE-GAN). Multiple subsets were extracted using under-sampling and SMOTE was applied to generate less skewed sets to prevent the GAN from modeling the noise. These subsets were used to train diverse sets of GAN models to generate the synthesized subsets. A set of Random Forest classifiers was then trained based on the proposed ESMOTE-GAN technique. The probabilistic outputs of the trained classifiers were combined using a weighted voting scheme for decision-making. The results show that the proposed model achieved 1.9%, and 3.2% improvements in overall performance and the detection rate, respectively, with a 0% false alarm rate. Due to the massive number of transactions, even a tiny false positive rate can overwhelm the analysis team. Thus, the proposed model has improved the detection performance and reduced the cost needed for manual analysis.


In the technological world there are number of technologies which are generating a large amount of data day by day that leads to formation of a technology called Big Data. Big Data deals with the large and unstructured data that can be computationally analysed to reveal the trends and patterns of a data. In this paper the basic program called Word Count Map Reduce program executed in apache hadoop with a single node setup. Altering in input files and reducing the number of tasks that makes the changes in execution of a program. The aim of this paper is running the Word Count program with different parameters. Keywords—Word Count Program, Apache Hadoop, Map Reduce, Big Data, Parameters


The seismic vulnerability of an existing two span reinforced concrete slab bridge with round columns as piers was studied for its retrofit design. First, the bridge design was checked by American Association of State Highway and Transportation Officials (AASHTO) seismic provisions, showing that the bridge is seismically weak in bending resistance and particularly shear resistance of its piers columns. Next, a push over analysis (POA) was performed, for which the target displacement was calculated by shear-displacement relationship for the center of gravity of the bridge deck. The rotations of plastic hinges in columns, obtained by POA were compared with the FEMA 356 acceptance levels, which confirmed the high vulnerability of the bridge. Finally, three various retrofit designs, including: 1) adding the strength and stiffness of pier columns by R/C jackets, 2) adding some steel diagonal elements in both lateral and longitudinal directions, and 3) fixing the deck to abutments connections in lateral direction to make it possible to use the abutment walls as shear walls, were considered and checked by both POA and Nonlinear Time History Analyses (NLTHA). The bridge specifications for NLTHA were defined based on FEMA 356 regulations by using the AASHTO design spectra. Several accelerograms, with the PGAs compatible with the level of seismic hazard in the site and the frequency contents compatible with the conditions of the bridge site soil, were used for NLTHA. The analyses results show that all three proposed retrofit designs are acceptable, however, the third method seems to be practically and economically more feasible.


The case of Flomo v. Firestone Natural Rubber Company involves child laborers' claims that labor practices on a Liberian rubber plantation violate international norms. Though the case was recently resolved in favor of the defendants at the district court level, the case's complicated procedural and substantive history offers insight into the viability of future child labor claims. This Note examines the Flomo case and explores how standards from the ATS and the United States Supreme Court case Sosa v. Alvarez-Machain apply to future plaintiffs' claims. This Note also analyzes the potential repercussions that plaintiffs face in using the ATS as a tool to influence global child labor practices and highlights the realities of ATS child labor litigation.


A smooth hypersurface over a finite field $\mathbb{F}_q$ is called Frobenius nonclassical if the image of every geometric point under the $q$-th Frobenius endomorphism remains in the unique hyperplane tangent to the point. In this paper, we establish sharp lower and upper bounds for the degrees of such hypersurfaces, give characterizations for those achieving the maximal degrees, and prove in the surface case that they are Hermitian when their degrees attain the minimum. We also prove that the set of $\mathbb{F}_q$-rational points on a Frobenius nonclassical hypersurface form a blocking set with respect to lines, which indicates the existence of many $\mathbb{F}_q$-points.


Conductometric method was applied to the appraisal of efficacy of scale inhibitors. The conductivities of a super-saturated CaCO_3 solution with and without the addition of a scale inhibitor were measured. Upon the addition of a certain scale inhibitor, the degree of supersaturation will change, and the degree of super-saturation was used as a measure of the efficacy of the added scale inhibitor. By this simple and convenient method, the efficacy of different kinds of scale inhibitor was compared and appraised, and this method was proved to be more accurate, precise, convenient and rapid than the standard method HG/T 2094-1991.


This paper demonstrates the implementation of PID controller tuning using evolutionary technique which is Genetic Algorithm (GA). The optimal PID control scheme is applied to higher order system. The execution of this evolutionary strategy is evaluated by setting the objective function as mean square error (MSE), Integral time absolute error (ITAE) and Integral absolute error (IAE) one at a time. This technique will determine the global minimum value of its objective function and hence gives the optimal value of the gain parameters. The PID controller performance analysis using ZieglerNichols Tuning methodology and Genetic Algorithm is also demonstrated in this paper.


Wastewater treatment plant (WWTP) has become one of the most important structures nowadays and concrete is considered to be the most suitable material for the construction of this kind of structure for its several useful properties like durability, compressive strength, impermeability, abrasion resistance, etc. However in an aggressive environment, with the effects of constituents of wastewater and different chemicals applied in the treatment process of wastewater, concrete's performance is greatly challenged. Chemicals like acid, sulfides, sulfates, salt, and gases generated from different reactions, micro-organisms, etc. can cause chloride ingress, carbonation, corrosion, sulfate attack, bio-deterioration, and erosion of concrete in wastewater treatment plants. As a consequence, a large amount of money is spent on the maintenance and repair works for wastewater treatment plants every year. Therefore, the quality of the concrete used in structures like WWTP must be very high. This study aims to explore the detrimental effects of various harmful chemicals on concrete in wastewater treatment plants, degradation mechanisms, and different methods of enhancing the resistance of concrete. The study also represents the current scenario of Bangladesh regarding this issue with the help of some excellent references, codes, and guidelines of important organizations and practical surveys.

https://universepg.com/public/storage/journal-pdf/Chemical attack on concrete in wastewater treatment plant_a review.pdf


After completing the first edition of his Essais in 1580, having spent two years suffering from kidney stones, secluded in his tower in the provinces of Bordeaux, Michel de Montaigne makes a bold move: he decides to embark upon a long journey to Italy via Germany and Switzerland on horseback. The details of this journey come down to us today in a narrative posthumously entitled Journal de voyage, a work based on a manuscript recovered only in the eighteenth century. Until


This research aimed to investigate the English needs of Tour and Travel Department at Vocational High School Negeri 1 and Vocational High School Negeri 7 in Bengkulu City. The research used mixed method and convergent parallel design. The sample of this research consisted of three groups of respondents. First group was students, consisted of 28 active students and 4 alumni. Second group was English teachers, consisted of 2 English teachers. The third group was stakeholders, consisted of two heads of the Tour and Travel Department, two assistances of curriculum, hotel, and tour staffs. The data of this research were gathered by using adapted questionnaire and interview. The questionnaire was analyzed quantitatively and interview was analyzed qualitatively. The data were combined by using convergent parallel design. Results of this research indicated that listening and speaking are the two prioritized skills needed by the tour and travel department. Topics of speaking which has the greatest importance are flight reservation, prices and payment, tourist destination, tourist attraction, direction, and booking hotels. Topics of listening which has the greatest importance are flight reservation, booking hotels, direction, job interview, complaints, and cultural tourism.  Topics of reading which has the greatest importance are memos, letters, cultural tourism, handling a complaint, and tourism terms. Topics of writing which has the greatest importance are rules and regulation, instruction.


To study the evolution of entrepreneurial networks, the authors followed a single firm for three years and collected data on changes in the discussion networks of the entrepreneurs. Whereas previous research has demonstrated the heterogeneity of networks between firms, this paper shows how entrepreneurs inside an organization differ in terms of networks and network resources. The authors combine the network data with qualitative interview data in an attempt to explain the observed individual-level differences. On the basis of the empirical material, they present a series of propositions linking individuals, entrepreneurial teams and network evolution.


Object:The experiment was conducted to study on the antioxidation capability of W-FOS (Microwave-assisted synthesis of fructose-oligosaccharide) and 5-HMF (5-hydroxymethylfurfural) which was produced in the synthesis process. Method:The clearance capability to DPPH,ABTS+ of W-FOS and 5-HMF was determined. 50 male KM mice were randomly divided into 6 groups:control group,high-fat diet group (HFD,20% fat w/w),HFD+0.5% E-FOS (Fructose-oligosaccharides by enzymatic synthesis ) group,HFD+0.5% W-FOS+5-HMF group (5-HMF content were 0.2%,0.02%,0.0% w/w). After 5weeks,the antioxidation capability was measured. Results:W-FOS had clearance capability to DPPH and ABTS+,and 5-HMF could enhance the capability. E-FOS、E-FOS,W-FOS+HMF group could significantly reduce the blood lipid of high serum lipid (HSL)mice (p0.05). Adding W-FOS with middle and low level 5-HMF could recover the plasma T-AOC,CAT,MDA,ROS of HSL mice significantly,while W-FOS with high level 5-HMF had significant effect on plasma CAT and ROS. The protective effect of W-FOS with middle level 5-HMF on HSL mice liver's antioxidation capability was superior to the effect of W-FOS with high level 5-HMF. Conclusion:Both W-FOS and 5-HMF had clearance capability to DPPH and ABTS+. 0.5%W-FOS with 0.00%~0.02% 5-HMF had protective effect on blood lipid,plasma and liver antioxidation capability of HSL mice.


We analyze URL and tag propagation on Twitter social network with 54 million nodes and 1.5 billion edges, one of the largest social networks studied in academia. We specifically focus on the interplay of external and network influences. We attribute propagation to the network whenever a user mentions a tag or URL after one of its neighbors has previously mentioned it, and to external influence otherwise. We develop a new metric to measure external influence and an efficient algorithm to calculate it. The insight we obtain from the external influence metric paired with the analysis of cascade dynamics of the network influence, not only validates some of the previously observed phenomena in other social networks but also provides new insight into the interplay of network and external influences over the lifetime of memes in the network.


The sequencing and synthesis of mammalian lu teinizing hormone-releasing hormone (LHRH) 1-4 led to the expectation that this decapeptide would prove useful for therapy of infertility of hypothala mic origin. It was also forecast that substitution of some of the amino acids in the molecule might lead to competitive antagonists, useful as a new method of contraception. As it turned out, substitution led more quickly to increased agonist potency; many more years were to elapse before clinically evaluable antagonists appeared. LHRH is


Lower respiratory tract infections (LRTI) are among the most common human infectious diseases worldwide and responsible for a considerable number of deaths among children, particularly in developing countries. Respiratory tract infections are caused by broad spectrum microbial agents, mostly viruses and some bacteria. The common of respiratory viruses includes influenza virus A and B, parainfluenza viruses, adenoviruses, respiratory syncytial virus (RSV), rhinoviruses, and coronaviruses. In Malaysia, studies on the prevalence of these viruses are still lacking of data presentation of the virus prevalence associated with LRTI. The purpose of this study was to detect the respiratory virus aetiology from patients in Sungai Buloh Hospital, Selangor who were hospitalized with lower respiratory tract infections. A total of 210 specimens and patient's data were collected from patients hospitalized with LRTI. The specimens were collected from April 2013 until early January 2014 after routine immunofluorescence (IF) test in hospital. Samples subjected to viral nucleic acid extraction and PCR for adenovirus, bocavirus and RSV detection. Positive PCR samples were sequenced and phylogenetic trees were constructed. Sample then analyzed based on demographic and clinical data. PCR result revealed 18 samples that were positive with adenovirus which were 11 of HAdV-7, two HAdV-1, HAdV-2 and HAdV-4 respectively and one was HAdV-5 while two positive PCR samples were HBoV1. Hospital IF test reported presence of RSV, influenza A, adenovirus, parainfluenza 3 and influenza B. Virus incidence was observed higher in children compared to adult with noticeable symptoms observed were cough, fever and difficulty of breathing, while asthma was the common underlying disease presented. Main diagnoses of the LRTI were pneumonia and bronchiolitis. In summary, viruses contribute to the etiology of LRTI among hospitalized patients in Hospital Sungai Buloh, particularly RSV followed by HAdV, influenza A, parainfluenza 3, HBoV and influenza B.


The application of large deep hole bench blasting with millisecond delay hole by hole was introduced in complex environment in aoshan oil reservoir excavation.It is important for designer to arrange blast hole by square,increase specific charge and over-depth of blast hole properly,high-precision detonator,and the firing order based on the shape of blast area and the rock stratum and the monitoring of blasting vibration.


A dual band-notched two-element UWB-MIMO step slot antenna with a very compact size of 23¡Á21¡Á0.8 mm3 is presented. By etching two rectangular slots from the middle of the ground plane, the impedance matching of the antenna in 3-4 GHz and isolation of two ports are considerably improved. With the implementation of three pairs of open-ended quarter-wavelength split slots near two radiating slots, two effective frequency notches are created at C-band and WLAN frequency band respectively in addition to a further reduction of mutual coupling at frequencies ¡Ü 7 GHz. The antenna has an operating band of 3.07-11.09 GHz with two sharply-notched bands of 3.71-4.38 GHz and 5.16-5.90 GHz, along with a low mutual coupling less than -18 dB over the entire UWB range. With ECC ¡Ü 0.004 and good pattern diversity, this antenna is a suitable candidate for UWB systems working with severe multipath fading and in-band interference.


As the war on terrorism continues abroad, the need to maintain security at home remains a major concern. Every aspect of the security effort can benefit from rapid information transfer. Advances in Commercial-Off-the-Shelf (COTS) radios make them valuable in applications ranging from deployed sensors on unsecured borders, to organizing an emergency response team. Additionally, the reduced cost and availability of these transceivers make them a viable alternative to custom developments. As an example, COTS radios can serve as the communication element in Unattended Ground Sensor (UGS) and munitions systems. Other applications include networked sonobuoys and networked RFID tracking. An additional advantage of COTS solutions is that they are available in a small form factor. They have extremely small mechanical outlines and are easily installed in systems requiring miniature designs and light payloads such as man-pack emplaced radios for the Army's Future Combat System (FCS), as well as missions carried out by Unmanned Aerial Vehicles (UAV). The availability of the COTS radios result in a low-cost alternative for communication links that are applicable to military and Homeland Defense projects. They provide an easily obtainable, low-cost radio alternative enabling quick design cycles to meet mission timeliness. COTS solutions eliminate months from a typical design cycle and have many features already implemented such as ad-hoc routing and encryption. This enables robust hardware to be fielded quickly when a new need arises. The focus of this paper is to identify different COTS modules that can efficiently and cost effectively be applied to these and other various applications.


In this article, I examine the connections between Christopher Marlowe's Doctor Faustus and sixteenth century Calvinist Christology. Focusing on the magician's response to various New Testament texts as well as his relationship to Mephistopheles, I argue that by replicating Faustus' appeal to utter subjectiveness in all that he does, many critics have neglected to consider the way in which relationality is dealt with both in early modern Calvinism and in the play By concentrating on the Calvinist conception of Christ as a masochistic paradigm of selfhood, the play offers a comment on the violence that underwrites this form of Calvinist subjectivity. But more than this, it also provides an analysis of a culture grappling with a radical shift in affective response to the saviour.


The real world is composed of sets of objects that move and morph in both space and time. Useful concepts can be defined in terms of the complex interactions between the multi-dimensional attributes of subsets of these objects and of the relationships that exist between them. In this paper, we present Spatiotemporal Multi-dimensional Relational Framework (SMRF) Trees, a new data mining technique that extends the successful Spatiotemporal Relational Probability Tree models. From a set of labeled, multi-object examples of a target concept, our algorithm infers both the set of objects that participate in the concept and the key object and relation attributes that describe the concept. In contrast to other relational model approaches, SMRF trees do not rely on pre-defined relations between objects. Instead, our algorithm infers the relations from the continuous attributes. In addition, our approach explicitly acknowledges the multi-dimensional nature of attributes such as position, orientation and color. Our method performs well in exploratory experiments, demonstrating its viability as a relational learning approach.


BACKGROUND
Periodontal disease is one of the most prevalent oral pathologies and a major chronic disease worldwide. Lifestyle habits such as poor nutrition and smoking have been established to contribute to the development of periodontal disease, but limited research investigated whether physical activity and sedentary lifestyle plays a role. The purpose of this study is to evaluate the association between physical activity, sedentary behavior, and periodontal disease.

METHODS
We used a nationally representative dataset from the National Health and Nutrition Examination Survey (NHANES) 2011-2012. We examined the association between physical activity and sedentary behavior and periodontal disease using multivariable logistic regression models and reported odds ratios (OR).

RESULTS
Individuals with higher total physical activity, higher leisure time physical activity, and lower amount of total sedentary behavior had lower periodontal disease prevalence. Adjusted multivariable regression models showed that higher sedentary behavior (more than 7.5 hours/day) was associated with higher odds of periodontal disease (OR= 1.17; 95% CI,1.00,1.36; p=0.045).

CONCLUSION
Findings showed that higher sedentary behavior is associated with higher odds of periodontal disease. Future prospective longitudinal studies and strategies are needed to investigate implications further and define the magnitude of the association between physical activity and periodontal disease. This article is protected by copyright. All rights reserved.


The empirical tuning of high temperature superconducting (HTS) filters is usually time-consuming and expensive. A computer-aided tuning method is presented in this paper. By means of optimization, the method diagnoses detuning of individual resonators quantitatively in the tuning process, and then by using neural network models the method is able to give the operator a decision on how much the corresponding tuning screws should be tuned. So, compared with the empirical tuning method, this method can be used to tune the HTS filters accurately with less time and cost.


Abstract Objective: Many interventions to reduce allergen levels in the home are recommended to asthma and allergy patients. One that is readily available and can be highly effective is the use of high performing filters in forced air ventilation systems. Methods: We conducted a modeling analysis of the effectiveness of filter-based interventions in the home to reduce airborne asthma and allergy triggers. This work used "each pass removal efficiency" applied to health-relevant size fractions of particles to assess filter performance. We assessed effectiveness for key allergy and asthma triggers based on applicable particle sizes for cat allergen, indoor and outdoor sources of particles <2.5 µm in diameter (PM2.5), and airborne influenza and rhinovirus. Results: Our analysis finds that higher performing filters can have significant impacts on indoor particle pollutant levels. Filters with removal efficiencies of >70% for cat dander particles, fine particulate matter (PM2.5) and respiratory virus can lower concentrations of those asthma triggers and allergens in indoor air of the home by >50%. Very high removal efficiency filters, such as those rated a 16 on the nationally recognized Minimum Efficiency Removal Value (MERV) rating system, tend to be only marginally more effective than MERV12 or 13 rated filters. Conclusions: The results of this analysis indicate that use of a MERV12 or higher performing air filter in home ventilation systems can effectively reduce indoor levels of these common asthma and allergy triggers. These reductions in airborne allergens in turn may help reduce allergy and asthma symptoms, especially if employed in conjunction with other environmental management measures recommended for allergy and asthma patients.


ACD1d-restricted subset of NKT includes conserved immune elements with positive and negative regulatory activity in immunity, including pathogen resistance. NKT cells have been shown to have physiological, protective effects in certain but not all virus infections via contributing to activation of first NK cells and subsequently, T and B cells. NKT cells can also promote the switch to a regulatory environment, limiting successful as well as pathologic adaptive responses. However, as with any immune element, excessive or chronic NKT proinflammatory activities can lead to tissue injury, for example, in myocarditis, lung diseases, and hepatitis, as a result of viral infections. The NKT role in influenza infection is only recently becoming clear. Although in certain pulmonary infections, NKT cells can promote damaging inflammation, several recent studies, including one in this issue of the Journal of Leukocyte Biology [1], find that NKT can limit excessive lung inflammation by monocytic-type myeloid cells. CONTRASTING ROLES OF NKT CELLS IN IMMUNOSURVEILLANCE VERSUS IMMUNOPATHOLOGY WITH DISTINCT VIRUSES


Objective To establish a method for determination of bisphenol A(BPA)and 4-nonylphenol(4-NP)in milk by cloud point extraction(CPE)and high performance liquid chromatography(HPLC).Methods BPA and 4-NP in milk were extracted and preconcentrated by a pretreatment method known as CPE The best de-emulsification conditions were:200 μL glacial acetic acid and 0.900 g Na_2SO_4,centrifugation at9917.355 g(10000 r/min),8℃,10 min,with the volume of milk being 10 mL.The optimal cloud point extraction conditions were:100 g/L concentration of Tween 20,0.20 g Na2SO4 and 200 μL n-butyl alcohol,equilibrated at 60℃ for 30 min.Results BPA and 4-NP had a good linear relationship in range of 0.05 to2.00 mg/L and 0.1 to 5.00 mg/L,respectively.The linear correlation coefficients were above 0.999.Recoveries of Bisphenol A and 4-NP were between 80.5%~96.6%and 70~84%with relative standard deviations of 3.42 to9.85%.The limit of detection was 7.36 μg/kg and 93.19 μg/kg,respectively.Conclusion This method has the advantages of less organic solvent consumption,high extraction efficiency,environmentally friendly and simple operation.It is efficient and reliable for the determination of BPA and 4-NP in milk.


Freeform micro-optical elements on foil are showing a great potential because of combining the unique ability of freeform optical surfaces of achieving desired radiant intensity or irradiance distributions with the compactness of light management foils.


The recent development of electronics and technological advances in wireless networks have led to the development of miniaturized wireless sensors, that can be used in the field of remote healthcare patients monitoring. When interconnected in a Wireless Body Area Network (WBAN), these tinny sensors, can be positioned on or implanted inside the human body to continuously monitor several physiological parameters (temperature, blood pressure, ECG, etc. …) of the patient.The purpose of this paper is to compare the impact of the two modulation schemes specific to the NB physical layer at 2.4Ghz when the scheduled access is considered, for a WBAN model consisting of 11 sensor nodes (one of which is the hub) based on the IEEE 802.15.6 standard. The numerical study focuses on three metrics: packet reception, latency, and node-level energy consumption, and is performed using the Castalia 3.3 framework, based on the OMNeT ++ platform (4.6).Castalia simulator supports the IEEE 802.15.6 standard, which justifies the choice of its use in the simulations carried out.


A comprehensive investigation has been performed on the hardness, tensile properties, microstructure, and fracture behavior of arc‐melted W and W‐Ir alloys at room temperature and from 1600 K to 2600 K. The objectives of the present study were to examine solution softening effect of Ir in W at room‐temperature, and to characterize the strength properties of dilute W‐Ir alloys as the functions of iridium content at high temperatures. Tensile tests were conducted in a vacuum better than 1.3×10−5 Pa (10−7 torr) with a strain rate of 10−3/sec. It was found that iridium was more effective insoften and ductilize tungsten than rhenium at room temperature, and the minimum hardness and maximum elongation occurred at iridium content about 0.4 wt.%. In dilute W‐Ir alloys, the high‐temperature strength increment was proportional to the atomic content of iridium. And the addition of iridium in arc‐melted tungsten substantially increased both the strain‐hardening exponent and the activation energy of plastic deformatio...


The surface emissivities of medium carbon steel and die/mold steel,common carbide and coated carbide are calibrated with an infrared imager within the temperature range of 300~900 ℃.The heat radiation influence of the heating stove environment on the specimens is considered,and the effects of temperature,surface structure and geometry of the specimens on their surface emissivity are analyzed.The investigation results indicate:with the increase of temperature,the emissivities of these steels increase,but the die/mold steel keeps a small emissivity within a relatively wide temperature range;the sample surface evenness influences the surface emissivity;the coated tool keeps a stable and quite small surface emissivity.


The condition of tank bottom corrosion is the determinant factor affecting the safe operation of the tank. Considering the difficulty to shut down and carry out testing on tank floors, This article determines the characteristic parameters of tank bottom corrosion based on tank bottom magnetic flux leakage testing results and the fuzzy support vector machine is established based on the characteristic parameters of tank bottom corrosion. Through the prediction and analysis on 25 tanks in a depot, comparing with the result of magnetic flux leakage test, coincidence rate reaches 100%.The results show that this prediction technique is able to resolve the problem of the prediction of tank bottom corrosion rank, and can be applied in engineering applications.


In the personal essay Hejira, David Sedaris recounts the day his father kicked him out of the house at the age of twenty-two. David was confused at his mother's inconsolable crying as she said goodbye, because unbeknownst to David, his father had kicked him out because he was gay and not, as David originally assumed, because he was a bum.


The objective of this work is to develop a cooperative hypermedia framework that enables actors to cooperatively create, use, and modify versioned hypermedia documents. A rich set of cooperation policies, based on hypermedia documents, access rights, and synchronization contracts, have been defined to support flexible cooperation control.


The high and increasing rate of opioid use is a serious issue in the Western world affecting the population's physical and mental health. In most cases, opioid dependency starts with prescriptions by medical professionals, so efforts aimed at reducing in‐hospital opioid use should result in less long‐term dependency. The aim of the current study was to evaluate the feasibility of implementing an opioid‐scarce protocol as part of a new online modifiable Enhanced Recovery After Surgery (mERAS) programme.


Insecticidal influence of neem seed acetone extract was observed on the third instar larvae of Corcyra cephalonica (Staint.). This extract caused a depressive effect on the developmental stages of this moth. A dose level of 0.16% (a.i) v/w of this extract caused 100% larval mortality, which may be considered as extremely toxic to the pest.


expressing surprise that ethnic Chinese Muslims were also attacked in May 1998, but this line of analysis does not go further than this. Did the need to heal the past inform the Chinese Muslim community's own drive for political and social participation post-New Order? Nonetheless, the author's overall thesis, well borne out here with case studies, is that a plurality of identities can and does exist in Indonesia, of which the Chinese Muslim is an important example. The cosmopolitan, open and inclusive ways in which places of worship such as the Surabaya Cheng Hoo Mosque have become spaces with multiple uses for different communities and 'boundary crossings' demonstrates this very well. Whilst I am slightly nervous overall about the success of the term and indeed the phenomenon of 'Chinese euphoria', this study enhances our understandings of what life in Indonesia looks like at the points of intersection between this ethnic minority and religious majority in a way that provides for optimism.


People at ancient days are purely depends on herbal drugs. Why because at that time Allopathic system of medicine had not came into existence. Now days both Ayurveda and Allopathic systems of medicine had been flourishing because most of the chronic diseases are completely not eradicated by Allopathic drugs. For this reason Ayurvedic drugs are more preferred than Allopathic drugs. In India 3000 plants are used for the medicinal value. In general 6000 medicinal plants in India are in use in traditional, folklore and used as a herbal medicine. This article aims to provide a comprehensive review in Ayurveda for the pharmacological aspects of Antiasthamatic activity, loss of semen, blood vomiting, diarrhoea, blood motion, vatha, pitha, kapha, white discharge, impotency, strengthening of body, tooth ache, Cough, Mouth sores, Pneumonia, Skin crack, Burn etc


Abstract This study was endeavoured to contribute in furthering our understanding of the molecular epidemiology of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by sequencing and analysing the first full-length genome sequences obtained from 48 coronavirus disease-2019 (COVID-19) patients in five districts in Western Serbia in the period April 2020–July 2020. SARS-CoV-2 sequences in Western Serbia distinguished from the Wuhan sequence in 128 SNPs in total. The phylogenetic structure of local SARS-CoV-2 isolates suggested the existence of at least four distinct groups of SARS-CoV-2 strains in Western Serbia. The first group is the most similar to the strain from Italy. These isolates included two 20A sequences and 15−30 20B sequences that displayed a newly occurring set of four conjoined mutations. The second group is the most similar to the strain from France, carrying two mutations and belonged to 20A clade. The third group is the most similar to the strain from Switzerland carrying four co-occurring mutations and belonging to 20B clade. The fourth group is the most similar to another strain from France, displaying one mutation that gave rise to a single local isolate that belonged to 20A clade.


Summary The Swedish painter David Kloker Ehrenstrahl proves to be pure German in his artistic ideas, especially in his early works. He was born in Hamburg and worked in Holland for a couple of years together with his countryman Jurian Jacobsz. It has therefore been stated in all the literature about him that Dutch influences were observable in his works, which is not true. He employs a method that is common among German artists and quite different from the manner in which the Dutch painters worked. After his visit to Holland Ehrenstrahl came to Sweden, but whether in 1651 or in 1652 is not quite certain. There are eight of his early works in the collection at the castle of Skokloster on Lake Malar, not very far from Stockholm. They are signed and dated 1651 or 1652. It is now clear, however, that Ehrenstrahl did not take the direct way from Holland to Sweden. Ehrenstrahl was summoned to Wolgast, the residental capital of Pomerania, by Count Charles Gustavus Wrangel, a Swedish General famed in the thirty Y...


Sylvia Plath as a confessional poet is considered a representation of American femininity. She was a substantial poet who used diverse images, terms, and symbols in order to express her feelings and concerns. This study seeks to analyze the role of love in her poetry and how it helped her deliver her feminist desires and attain freedom. What makes this research new is that Plath's life which looked like a mystery has been highly appealing to her readers and other researchers. Hence, the current study may be regarded as a positive step toward a better appreciation of her life and career. It is ultimately found that Plath's use of love in her poetry is rooted in her relationship with such men as her husband. Due to this relationship, Plath had a puzzling viewpoint regarding love which seemed to be simultaneously redeemable and destructive.


Avascular Necrosis (AVN) is a progressive degenerative condition of bone, caused by interruption to the blood supply. While it can affect any bone, AVN is especially common in the hip joint. Disease has very poor prognosis in modern orthopaedic practice. Treatment aspect of AVN in contemporary science revolves around the pain relieving medicine to total hip replacement surgery, which have drawbacks of long term recovery and short life span of hip joint. On contrary Ayurvedic treatment provides long term relief and stops the progression of disease without any drawback. There is no direct co-relation of AVN and Asthi-Majja GataVata but on their clinical presentations it is Vata Pradhana Tridoshaja Vyadhi with Vikruti of Asthi-Majja Dhatu. Following is documentation of improvement in patient diagnosed with AVN.  A male patient of age 50 years consulted to OPD department, with complaints of pain in bilateral hip joints (right more than left) with difficulty in walking since 8 months. The patient was treated with Tikataka Ksheera Basti Chikitsa as Kala Basti schedule. Hence the study concluded the Basti Karma is one of the potential treatment options in AVN management.


Objective To obtain the cDNA sequence encoding human α1-microglobulin/bikunin precursor (AMBP),and construct its recombinant cloning vector.Methods RNA was extracted from human embryo tissues of liver,kidney and pancreas with Trizol reagent.The sequence of human AMBP cDNA was cloned by RT-RCR from those RNAs,and inserted to pMD18-T vector.The recombinant vector pMD18-T-ambp was identified by restriction endonucleases SalⅠ/ EcoRⅠand DNA sequencing.Results The ambp gene fragment was obtained by RT-PCR only from liver RNA,but not from kidney and pancreas.A DNA fragment of 1 098 bp,consistent with the size of ambp gene fragment,was generated by digesting the recombinant plasmid with the restriction enzymes SalⅠ/EcoRⅠ.The results of sequence analysis showed that the constructed AMBP cDNA sequence was identical to the published one in GenBank.Conclusion The human AMBP cDNA is obtained successfully and the recombinant cloning vector pMD18-T-ambp is constructed correctly.


The essence of venture capital as one of the main sources of formation of the innovative companies reveals in the article. The specific character of venture financing and the main directions of its implementation is defined. The factors slowing down innovative development of economy are concretized and measures of increase of efficiency of venture investment are outlined.


Carbon to helium ratios and ionization fractions are derived for 74 WC stars in the Galaxy and the LMC from optically thin recombination lines at visual wavelengths. The range of C/He ratios is 0.13 to 0.79 by number, similar to the ratios calculated by Nugis (1975) and about 20 times greater than the ratios of Smith and Willis (1982). These ratios also agree with the abundances determined in the most recent evolutionary models of massive stars, which include mass loss, convective dredge-up, and new nuclear reaction rates. The range of values found for the C/He ratios implies that the convective cores of WC stars do not occupy a very large mass fraction. The C/He ratio differs within a subtype by a factor of three or less, but the mean tends to increase toward earlier subtypes, although the standard deviation from the mean is large enough to allow the interpretation that the C/He ratio is constant for all WC subtypes. 40 references.


CORAL reefs are found in tropical waters and constitute 15% of the world's shallow sea floor (0-30 m). Their biogenesis is a result of calcification by either plants. or animals which harbour zooxanthellae; symbiotic unicellular dinoftagellates of the genus Symbiodinium. A major focus in recent reef research has been the study of this symbiotic association between algae and host at the cell biology and molecular level. This is important not only to gain a deeper understanding of the association and therefore the functional advantages inherent in the symbiosis but on a more practical level it is necessary to understand the response of these associations to nutrient loading and pollution and to explain coral bleaching. While corals represent the most globally significant zooxanthellae symbiotic association, as far as scientific research is concerned corals have both geographic and technical drawbacks. As a result other organisms, such as sea anemones, have actcd as model systems and there has been a trend to extrapolate results with these animals to all other zooxanthellate symbioses, the supposition being that, biologically and metabolically, their behaviour is similar or identical. While there is a recognition that the hosts themselves are dissimilar, it was believed until recently that there was a unifying


INTRODUCTION
From 1986 to 1999 we operated on 963 patients with primary hyperparathyroidism (pHPT).

METHODS AND RESULTS
Parathyroid carcinoma was diagnosed clinically and histologically in four patients (0.4%). In two of these patients diagnosis of parathyroid cancer was delayed by misinterpretation of the histopathology leading to an autotransplantation of malignant parathyroid tissue in one case. In two patients multivisceral surgery was performed: beside thyroidectomy, neck dissection, tracheal wall resection and resection of the muscular layer of the oesophagus one patient received oesophagectomy and gastric transposition and one patient a lung wedge resection. Both patients had a temporary palliation of tumour-associated symptoms after multivisceral surgery. The first patient died 2 years after oesophagectomy and 12 years after primary diagnosis from local tumour recurrence and cachexia. The second patient is living with tumour recurrence presenting a serum calcium level of 4.2 mmol/l (normal range 2.0 to 2.5 mol/l) and multiple brown tumours 2 years after lung resection and 6 years after the primary diagnosis.

CONCLUSIONS
We conclude that parathyroid carcinomas, being difficult to diagnose, warrant radical surgery, including multivisceral resection to prolong survival and reduce tumour and hypercalcaemia associated symptoms.


Artifice physio usual oral addressed to the dental field toilet clinical sector, especially periodontics. When dosed preparations dental medical use. Preventive hygiene sector, relax and oral exercise. Complete healing processes, relieves inflammation with the properties of the multifunction invention meets a closed circuit (11) with cooling fluid cools the environment system (15) which reduces the temperature at the point of contact. A supplementary dispenser, filling the supplied scents (1) integrated package dispenser of any contrivance (2) balsamic essence, medical preparations or toilet. It facilitates oral hygiene with or without water. Essences water the head (16) of its devices lubricating apparatus: relaxing spheres, sheets hygiene, dental straight and curvilinear fiber (21) exercise device and the oral environment. The functions can be performed manually or automatically, by the user, coupling (25) the ergonomic activator.


Aldehydes and ketones are converted to homologous carboxylic acids by reaction with dithiane oxide (I) and subsequent acid-mediated cleavage of the resulting intermediates.


An FeS2 (pyrite)/reduced graphene oxide (FeS2/RGO) heterojunction was synthesized by a facile and effective hydrothermal method. X-ray diffraction proved the high purity of the as-prepared product, and both scanning electron microscopy and transmission electron microscopy showed that FeS2 particles were well distributed on RGO nanosheets with controlled size and morphology. The performance of the FeS2/RGO composites as lubricating oil additive were investigated on a ball-plate tribotester. The results indicated that FeS2/RGO could improve the load-carrying capacity dramatically, as well as the friction-reduction and anti-wear properties of the paraffin oil. In addition, higher GO content is beneficial to improve the lubrication properties of FeS2/RGO composites. The excellent lubrication performance of FeS2/RGO composites can be attributed to the unique layered structure of FeS2 and RGO.


1 The changes in the free cytosolic Ca2+ concentration ([Ca2+]i) in response to agonists of P2‐purinoceptors were studied in myocytes isolated from the longitudinal muscle layer of different regions of the rat gastrointestinal tract (stomach, jejunum, ileum, caecum and colon). [Ca2+]i was estimated by emission from the fluorescent dye, indo‐1. 2 ATP and the P2Y‐purinoceptor agonist, 2‐methylthio‐ATP (2‐MeSATP), transiently increased [Ca2+]i in single myocytes from all segments of the gastrointestinal tract, whereas α,β‐methylene‐ATP, a P2X‐purinoceptor agonist, had no effect. 3 The rise in [Ca2+]i induced by ATP and 2‐MeSATP was maintained in Ca2+‐free solution but was abolished by depletion of the intracellular store with thapsigargin (1 μm). 4 Single myocytes from stomach, caecum and colon also responded to UTP by a transient increase in [Ca2+]i. 5 Individual myocytes responded to ATP, 2‐MeSATP and UTP in a nearly all‐or‐nothing manner. The increasing of agonist concentration enhanced the number of responding cells but did not increase the amplitude of the [Ca2+]i rise. 6 These results suggest that myocytes from the longitudinal layer of gastrointestinal muscle do not possess functional P2X‐purinoceptors and that agonists of P2Y and P2U‐purinoceptors induced a rise in [Ca2+]i, probably via an all‐or‐nothing mobilization of Ca2+ from intracellular stores.


One limitation of prior research in channel power is the absence of a conceptual framework which provides insights into the potential for firms to influence intra-channel power relations. This article develops the concept of customer-based channel power and introduces attribution theory as a framework to provide insights into channel power relationships. Specifically, channel members' marketing strategies are shown to influence consumer attributions which, in turn, influence the customer-based channel power of the respective channel members. The issue is important because firms with higher levels of channel power increase their ability to influence marketing decisions of other channel members and may more effectively implement their own strategies. Propositions are developed as guidelines for future research.


The Lorentz-Zygmund spaces L pa (log L) α are a class of function
spaces containing as special cases the classical Lebesgue spaces L p ,
the Lorentz spaces L pa and the Zygmund spaces L p (log L) α . It is
shown here that the Lorentz-Zygmund spaces provide the correct
framework for the interpolation theory of weak type operators. The
interpolation principles established here unify many classical results
in harmonic analysis. In particular, there are applications to the
Fourier transform, the Hardy-Littlewood maximal operator, the Hilbert
transform, and the Weyl fractional integrals.


The oxidation state of palladium in an electrode ink dispersion, air-dried on barium titanate dielectric substrates, has been studied using x-ray photoelectron spectroscopy (XPS) as a function of both firing temperature and firing atmosphere. Several different states have been identified in amounts which vary over the firing temperature range of interest, i.e. palladium metal, a so-called PdOads species, PdO and palladium in one or more higher oxidation states. No significant differences were observed for the two different contacting atmospheres used during firing, namely air and flowing nitrogen. Owing to overlap of the Pd 3p3/2 and the O 1s spectral envelopes, peak fitting of the oxygen signal was not attempted. Small amounts of residual carbonaceous ash were detected for all the samples studied over the whole range of firing temperatures employed.

XPS analysis of a sample of the palladium ink, fired to 1350°C in air and subsequently etched using a fast atom bombardment (FAB) argon source, showed that the sub-surface palladium was metallic in nature although the original metal surface was composed almost entirely of PdO. Thus, for these palladium inks, when fired to temperatures comparable with those used in multilayer ceramic capacitor (MLCC) manufacture, apart from a thin surface oxide layer the palladium present is in the metallic form, as required for electrode layer conduction.


Since the 18th century the 'contractual model' has become both a paradigm of social theories (f.i. 'rational choice') and a dominant model of structuring labour relations. Its presupposition of the subjectivity of individual actors as a given is criticized with reference to network-based theories (Latour, Callon) and to analyses of Foucault. The current contract model of labour relations is analyzed from a historical perspective on normative regimes of labour relations, that imply different conceptions of 'subjectivity'. Research into the regulation of labour relations requires an analysis in terms of an entanglement of human beings, technologies and legal discourse.


Higher Education Institutions (HEIs) under the Ministry of Education Malaysia (MOE) are considered as the catalysts for excellence in the national education sector. The education sector has always enjoyed the highest national development budget and this has proven that the government's commitment to the education is paramount. Growth rates for researching output and quality are among the highest in the world, and higher education institutions in Malaysia has achieved a strong ranking among their Asian counterparts. Malaysia must make adjustments, including transforming higher education systems to thrive in an increasingly challenging global economic environment. Therefore, a form of performance assessment mechanism needs to be developed to evaluate on the performance and quality of services delivered in line with the goals set. The Balanced Scorecard (BSC) is one of the most widely used assessment instruments in assessing the performance on the institution. Therefore, the purpose of this study is to highlight the importance of BSC in the measuring performance in the Malaysia HEIs. Many previous studies have been conducted to evaluate the effectiveness of BSC especially in corporate companies and the results of these studies show that BSC has a positive and beneficial impact on the organization. However, there are still fewer studies which involve the Malaysia HEIs in conducting BSC-based performance evaluations. In addition, a strategic map will be developed to guide the implementation of BSC in Malaysia HEIs. When implemented, it is hoped that the BSC can be used by management to assist in the implementation of long-term strategies as a tool in monitoring and evaluating the performance of Malaysia HEIs in addition to preparing for future educational challenges


A novel concept for dual beam laser lap joining of Zinc coated steel sheets without intended gap at the interface is presented. This concept utilizes two laser beams with an angle between them. This concept is first proved by combining two laser focusing heads (twin-head system) through use of a custom designed fixture. Welding trials were conducted with a robot by mounting the whole beam delivery set-up at the end of the robot arm. The effects of various welding parameters were studied through both experimental trials as well as modelling of the keyhole geometry. Based on successful concept demonstration, a prototype head was designed and built which enabled the realization of this beam configuration through a single laser source. Excellent quality welds were obtained with both the twin-head system and the new dual-beam head on a variety of zinc-coated sheet combinations.A novel concept for dual beam laser lap joining of Zinc coated steel sheets without intended gap at the interface is presented. This concept utilizes two laser beams with an angle between them. This concept is first proved by combining two laser focusing heads (twin-head system) through use of a custom designed fixture. Welding trials were conducted with a robot by mounting the whole beam delivery set-up at the end of the robot arm. The effects of various welding parameters were studied through both experimental trials as well as modelling of the keyhole geometry. Based on successful concept demonstration, a prototype head was designed and built which enabled the realization of this beam configuration through a single laser source. Excellent quality welds were obtained with both the twin-head system and the new dual-beam head on a variety of zinc-coated sheet combinations.


Properties of schiff bases and their metal complexes have been identified by various scientist s in the past and also lots and lots of work is alsogoing on to identify the unique properties of these schiff bases. Here another attempt was made to identify the properties of p -chloro aniline schiff base and its derivative. Major focus was given on antimicrobial activity of schiff base and its metal com plexes. Chemical properties were determined using UV Vis spectrophotometer, IR spectrophotometer and CHN analyzer.


An arrangement of pseudocircles is a collection of Jordan curves in the plane with at most two intersections between any two curves. We consider the question when such an arrangement can be realized with convex curves. We show that the existence of an open region which is contained in the interior of all curves of the arrangement is a sufficient condition for the existence of a convex realization.


The position of the original point of the tool-bar deflexion is determined in this paper using the pure bending theory of the strength of materials. And therefore the shape of the shaper-tool is obtained.


Most of routing algorithms for On-chip communication are neither application-aware nor routing packets using multiple paths. In addition, they hardly consider link bandwidth variation r esulting from widely applied global asynchronous local synchronous (GALS ) mechanism. In this paper, we propose a bandwidth-based application-aware multipath routing (BAMR) algorithm to assign multiple routing paths by leveraging the knowledge of application and network bandwidth features. With the increase of number of flows resulting from the split of flows, we present a new method named dynamic-amount fixed-number (DAFN) flow control mechanism to avoid deadlock. We compare our algorithm with XY, YX, an d O1TURN with synthetic traffic patterns and traffic trace of parallel implementation of H.264. Experiments demonstrate that BAMR achieves higher throughput with decrease in latency. Furthermore, the proposed algorithm achieves better workload balance by distributing traffic over multiple paths. To address the aforementioned three challenges, we propose a bandwidth-based application-aware mu ltipath routing (BAMR) algorith m. Our algorith m is flexible to different kinds of NoC topologies and traffic patterns. We first decide routing order of flows based on application graph and the bandwidth requirement. Then, considering the transmission capacity of network links, we split some flows into mu ltiple subflows to alleviate network congestion. Our algorithm can detect communication bottlenecks and make split based on link's residual bandwidth. For multipath routing, more flows may increase the possibility of deadlock. To this end, we propose a buffer management mechanism called dynamic- amount fixed-nu mber (DAFN), the number of Virtual Channels (VCs) for each individual router port and VC depth are predetermined at design phase based on the BAMR's results. Specifically, the number of VCs for a specified port at a specified router is depending on the number of flows passing through it. DAFN allocates each VC at a router with an identical global label with assigned flow's label. DAFN achieves deadlock freedom by restricting each flow to its exclusive VC, it takes full advantage of buffer space and avoids deadlock without additional hardware resources. Our work makes following contributions: We propose a mu ltipath routing algorithm named BAM R for GA LS No C. A flow splitting method aiming at to alleviate network congestion is presented, as part of BAMR.A static VC regulator named DAFN, with the co mbination of BAMR to make the full utilization of VC resources and avoid deadlock is also proposed.


This paper have studied embedding AgNO_3 to prepare iodide ion-selective electrode with sol-gel technology.The electrode showed Nernst response to iodide ion with a slope of 58.321 mV/pI~-,and a linear range of 10~(-1)~10~(-7)mol/L.The detection limit is 4.6×10~(-8)mol /L.The recovery is 97.4 %~103.2%.


We report the experimental results of the first MOSFET's ever fabricated using a laser plasma-source X-ray stepper. The minimum gate length of these transistors is 0.12 /spl mu/m with an effective channel length of 0.075 /spl mu/m. These transistors were patterned using a mix-and-match lithography scheme where the gate level was printed using a 1.4 nm plasma-source X-ray stepper while the other layers were patterned using optical lithography.<<ETX>>


Resting-state functional MRI (RS-fMRI) usually refers to the blood ogxygentaiton level dependent (BOLD) technique. It measures the sponta-neous or on-going brain activity during a continuous state (a few minutes or longer) without specific cognitive tasks. With the advantages of fairly good spatial (~3mm) and temporal resolution (0.1-2s), no radioactivity, and easy implementation, RS-fMRI is a promising functional neuroimaging technique for the diagnosis and to guide TMS treatment of brain disorders. Of the analytic methods, metrics for local activity (e.g., ALFF) and metrics for point-to-point functional connectivity showed potentials to guide TMS treatment. Multicenter data analysis is necessary to validate the reproducibility of abnormal brain activity, and hence, guide precise focused brain stimulation.


This paper describes an enhanced noninvasive continuous laser Doppler system for real time blood flow measurement in perfusion regions and larger vessels. The system consists of a miniaturized sensor, a fast digital signal processing (DSP) unit and a PC for signal visualization. The sensor comprises an IR laser diode to illuminate tissue through a short optical fiber with a variable spot size of 400 micrometers to 1000 micrometers and a photodetector which can be positioned 3 mm to 7 mm from the laser spot. The DSP of the system uses a parametric estimation of the laser Doppler power spectrum density based on a first order autoregressive process model AR (1) to calculate the first weighted moment. This algorithm is approximately ten times faster and as accurate as equivalent FFT-based algorithms. With a sampling rate of 390 kHz, it is possible to calculate and visualize 85 flow values per second. Model measurements prove very high linear correlations (r >= 0.99) between calculated first moments and flow velocities in a range from 1 mm/s up to 120 mm/s. Furthermore, in vivo measurement of blood flow both in perfusion regions and larger arteries, such as the a. radialis, were successfully performed in real time.


leading to more guilty navel-gazing this should encourage Scots (and others) to absorb the lessons of the past and get on with forging the multicultural present, itself one positive outcome of that compromised history. It's ironic that just when the ramparts around Blunkett's 'fortress Britain' rise higher by the month, Jack MacConnell's 'Fresh Talent' programme solicits foreign immigrants to settle in Scotland, part of a bid to staunch that continuing national trend – the haemorrhage of population. Maybe that will kill several birds with one stone: a recent survey shows that devolution is surprisingly popular amongst Scotland's ethnic minorities.


This guidance note was developed by the Financial Management Information Systems Community of Practice (FMIS CoP) for the development of change management programs to support the Public Financial Management (PFM) system reforms by: (i) reviewing the relevant literature and the World Bank activities/publications on change management and adaptive leadership; (ii) identifying important aspects of change management/leadership programs in successful FMIS and other PFM system reform projects; (iii) highlighting good practices in various regions; and (iv) developing a guidance note for the benefit of practitioners involved in the development of technological change management programs.


Background and Objective: This descriptive study aimed to evaluate the presence and frequency distribution of mosquito species in the city of Port Sudan, Sudan. Methods: After collection of 500 adult mosquitoes from different sectors of the city Port Sudan, they were classified using the morphological keys for identification of mosquitoes. Results: Overall, 230 Culex quinquefasciatus (46%) were detected in the eastern, central and southern sectors of the city. Culex sitiens (14.2%) were detected only in the central sector. Aedes aegypti (32.2%) were detected in all three sectors. Anopheles funestus (6.6%) were detected in the central and southern sectors. Conclusion: Cx. quinquefasciatus and Ae. aegypi are prevalent in all sectors of the city, while Cx. sitiens is prevalent only in the central sector. An. funestus is abundant in the central and southern sectors.


Wearable devices of today help people track and monitor their biometric data such as heart rate. While the tracked data can help inform people of their health, many find that it adds unnecessary anxieties in the way the feedback is provided. In the case of college students, they spend most of their time in a stressful environment, leading them to an increase in the risk of mental health issues. To help with this issue, we present Heart Waves, an experimental ambient feedback system that tracks heart rate and uses water sound to provide feedback in a stressful work environment. Heart Waves uses the sound of falling water to create a relaxing atmosphere to help ease any stress they are going through. As the user's heart rate goes up, the flow of water increases, and as their heart rate goes down, the flow rate of water decreases. The purpose of this project is to automatize the processing of heart rate data so that the user does not have to analyze the data and create an ambient feedback system that adjusts to their heart rate.


Summary: Non-canonical nucleic and amino acid monomers are essential to enhance the information capacity, functional capabilities, and stability of DNA, RNA, and protein biopolymers. However, there are few tools for describing the primary structure of biopolymers that include non-canonical monomers. We developed BpForms, the first toolkit for concretely and compactly describing the primary structures of non-canonical 1-dimensional biopolymers. BpForms includes the first alphabets of non-canonical DNA, RNA, and protein monomers; a FASTA-like notation for describing biopolymers; and a website, a command line program, a REST API, and a Python package for calculating properties of biopolymers. We anticipate BpForms will be a 1 ar X iv :1 90 3. 10 04 2v 1 [ qbi o. B M ] 2 4 M ar 2 01 9 valuable tool for communicating data about modified DNA, RNA, and proteins, as well as integrating data about epigenetic, post-transcriptional, and post-translational modification. BpForms will also be valuable for whole-cell modeling and cell engineering. Availability and implementation: BpForms is freely available open-source at https://bpforms.org.


1. Background The European Union (hereinafter EU or Union) is a single common market of 28 Member States (hereinafter Members). To achieve the objectives of single market, the EU has adopted a single customs tariff for the region and intervened to closely control national VAT systems. To date, it has not displayed willingness to take similar action with regard to Members' income tax systems. This paper argues this situation may not persist over time, putting forward three reasons the EU may shift its policy of limited intervention to one of the comprehensive intervention, not unlikely the approach it has taken in the field of VAT.


Background Disulfiram(DS), an old drug clinically used for alcoholism, was reported to have antitumor effects, recent studies have found that Copper(Cu) can significantly enhance the DS-induced cell death in vitro in a variety of tumor cells. Our previous studies also demonstrated that disulfiram/copper (DS/Cu) couldtarget human leukemia cell lines(like KG1α,Molt4) through the activation of JNK, in vitro. However, there is few report about the ability of DS/Cu in killing cancer cells in vivo. Aims This study aims to explore the effect of DS/Cu on acute myeloid leukemia cell line KG1αin vivo and clarify the underlining mechanism. Methods 6-8 week old female NOD/SCID mice were sublethally irradiated with 2Gy X-ray the day before transplantation, followed by intravenous injection of KG1α cells (1×107 cells) suspended in 0.2 mL of PBS. 5 weeks after transplantation mice were randomly divided into three treatment groups: vehicle (0.9% saline), a combination of DS and Cu daily for 2 weeks, Ara-C alone twice before killing. Mice were sacrificed after 2 weeks treatment with tissues of spleen, liver, bone marrow being observed using histopathology method to detect the invasion of leukemia. The DS/Cu-induced p-c-jun activation was also examined by western blot using tissues of spleen, liver, bone marrow. Statistical analysis was carried out with one-way ANOVA to assess statistical significance (*p Results 4 weeks after transplantation, mice were dispirited with low appetite, down-bent gait, wrinkled fur, slow move, just like suffered from leukemia. What's more, immature blasts like morphology similar to KG1α were found in the peripheral blood of the mice(11%±3.41). All the mice were sacrificed after 2 weeks treatment, mice in control group were observed with slightly larger spleen and liver with the morphology of invasion of leukemia such as a granular appearance than the other two groups. Histopathology examination showed that leukemia cells infiltrate liver, spleen and bone marrow, and the immunohistochemistry examination found that the leukemia cells in spleen, liver and bone marrow expressed human specific antigen CD45 with the highest expression level in the control group. Moreover, solid tumor could be observed in the peritoneal cavity of two mice in the control group with expression of human specific antigen CD45detected by immunohistochemistry examination. Western blot in this study showed DS/Cu complex induced phosphorylation of c-Jun expression in the spleen, liver and bone marrow. Conclusion DS/Cu complex could effectively target the acute myeloid leukemia cells in the acute leukemia NOD/SCID mice while inhibiting the invasion of leukemia to some extent, and the activation of JNK might play a functional role in DS/Cu mediated antileukemic effects. Disclosures: No relevant conflicts of interest to declare.


Beginning on March 26, 2012, the Supreme Court of the United States heard oral arguments regarding challenges to the recent federal health care reform legislation. The Court scheduled this unusually lengthy series of arguments to last for three days—a reflection of both the high stakes and the complexity of the legal issues involved. Whatever the Court ultimately decides, the outcome will have significant political and legal implications, as well as momentous practical consequences for virtually all stakeholders in the US health care system. In this article we provide a summary of the questions under consideration by the Supreme Court regarding the health care reform legislation, and we explore how the pending decision on this high-profile matter may impact the oncology community.


The renewed interest in colloidal thruster technology for micropropulsion applications has rekindled research on the physics of these electrically driven jets. In this paper we address two aspects of this topic. Firstly, from a numerical perspective, we explore the cone-jet transition region for a Formamide solution near the minimum flow limit (η ≈ 1). Secondly, from an analytical standpoint, we study the movement of charges within the colloidal jet and its effect on the non-neutral layer thickness. Numerical results have been obtained for a Formamide solution with conductivity K = 10−3Si/m for low flow rates 1 ≤ η ≤ 4. Our simulation is shown to conserve mass, charge and energy and our results show good agreement with published experimental data. For a high dielectric constant, the results also show finite conduction currents in the jet and a weak dependence of the convection current on flow rate. Analytical estimates have been obtained for the non-neutral and ambipolar layers created by an electrical field normal to the liquid surface. It is shown that the non-neutral layer is thin compared to the liquid jet. This result justifies the use of a constant conductivity in numerical models.


Abstract In this study, South African environmental analogues are identified for jojoba (Simmondsia chinesia). Thermohyet graphs and air mass characteristics are used to identify and delimit those areas Within the and zones of South Africa which are chmaltc counterparts of the jojoba source region. i.e. Arizona. Baja california and Mexico. These climaltically analogous regions are further subdivided into land suitability zones for jojoba production by assessing the degree to which specific,climatic and edaphic growth requirements are met. A scheme is devised which mvolves allocatmg scores to essenltal, Important, and less Important growth requirements in order to quantify the relative suitabilty for production. It is found that Prieska, Brandvlei, Boegoeberg and Oudtshoom have the highest production potential for jojoba, whtle the most severe environmental restriction occur at Okiep, Calvinia. Sutherland and Matroosberg.


Dopamine is a distinctive neurotransmitter, a chemical released by nerve cells to send information to other neurons and it plays a crucial role in brain and outside the central nervous system. Dopamine is extensively distributed in the cardiovascular systems, hormonal and memory and acts as a unique neurotransmitter that possesses the inhibitory and exhibitory behaviours [1]. Inhibitory neurotransmitter reposes the brain while the agitation of the brain is caused by the exhibitory neurotransmitter [2]. Dopamine is a small biomolecule and often present in biological matrices and commonly detected in urine, blood or high concentration of extracellular fluid in the body [3]. To date, several advanced analytical methods with excellent sensitivity and selectivity have been discovered for detecting dopamine in biological samples. However, the best alternative for sensing of dopamine is by using an electroSynthesis and Characterization of Magnetic Fe3O4/Reduced Graphene Oxide and its Application in Determination of Dopamine


A simple and convenient 3-D temperature simulation model is developed to deal with the large amount of CPU time in this paper.The control equations are solved with the arithmetic operator splitting technique according to the characteristic of each physical process.That is,the implicit scheme is used in fast physical processes while the explicit scheme is used in slow physical processes.The baroclinic pressure gradient expression and horizontal diffusion expression in sigma coordinate are treated by the removal of z-plane mean value.At last,the model is applied in two examples cases,which show the model is reliable and efficient.


An Autonomous Mobile Robot (AMR) is a machine able to extract information from its environment and use knowledge about its world to move safely in a meaningful and purposeful manner. Robot Navigation and Obstacle Avoidance are from the most important problems in mobile robots, especially in unknown environments. It must be able to interact with other objects safely. Several techniques such as Fuzzy logic, Reinforcement learning, Neural Networks and Genetic Algorithms, have applied to AMR in order to improve their performance. During the past several years Hybrid Genetic-fuzzy method has emerged as one of the most active and fruitful areas for research in the application of intelligent system design. The objective of this work is to provide a Hybrid method by which an improved set of rules governing the actions and behavior of a simple navigating and obstacle avoiding AMR. Genes are in the form of distances and angles labels. The chromosomes are represented as a rule written in a Boolean algebraic form. The method used to enhance the performance employs a simulation model designed by using Visual Basic software.


Scanning tunnelling spectroscopy (STS) and microscopy (STM) were performed on the paramagnetic molecular superconductor β′′-ET4[(H3O)Fe(C2O4)3]·C6H5Br. Under ambient pressure, this compound is located near the boundary separating superconducting and insulating phases of the phase diagram. In spite of a strongly reduced critical temperature Tc (Tc = 4.0 K at the onset, zero resistance at Tc = 0.5 K), the low temperature STS spectra taken in the superconducting regions show strong similarities with the higher Tc ET κ-derivatives series. We exploited different models for the density of states (DOS), with conventional and unconventional order parameters to take into account the role played by possible magnetic and non-magnetic disorder in the superconducting order parameter. The values of the superconducting order parameter obtained by the fitting procedure are close to the ones obtained on more metallic and higher Tc organic crystals and far above the BCS values, suggesting an intrinsic role of disorder in the superconductivity of organic superconductors and a further confirmation of the non-conventional superconductivity in such compounds.


Abstract 618

Disorders of hemostasis are frequent in patients suffering from classic myeloproliferative neoplasm (MPN) i.e. essential thrombocytemia (ET) or polycythemia vera (PV). They include high incidence of thrombosis, which represents a leading cause of morbidity and mortality, and a lower incidence of hemorrhagic events. The pathogenesis of hemostatic disorders is complex. The JAK2V617F mutation is found in 95% of PV and in 50% of ET. Since receptors coupled to JAK2V617F are hyper-responsive to growth factors, it is proposed that JAK2V617F primes platelets and, as a consequence, directly contributes to the thrombotic risk. However, the relation between the mutation and thrombosis has yet not clearly been established due to variable JAK2V617F allele burden and antithrombotic prophylaxis. Novel MPN animal models expressing the mutation have been developed with reported hemostasis disorders from unknown origin. Therefore, we took the opportunity to use these JAK2V617F knock-in (KI) mice to investigate the effects of JAK2V617F on platelet functions.

We used irradiated WT recipient mice grafted with bone marrow (BM) cells from JAK2+ /V617F KI donor mice. JAK2+ /V617F KI mice were conditional floxed JAK2+ /fl mice crossed with transgenic mice expressing Cre under the control of the vav promoter ( vav Cre/JAK2+ /V617F ) or Cre-tamoxifen-inducible transgenic mice expressing CreERt under the HSC-SCL promoter ( scl CreERt/JAK2+ /V617F ). All recipient mice developed 4 weeks after transplantation ( vav Cre/JAK2+ /V617F ) and tamoxifen-induction ( scl CreERt/JAK2+ /V617F ) a MPN mimicking PV and characterized by elevated hematocrit, platelet and leucocyte levels. Mice were studied between 4 and 9 weeks after the graft or 7, 14, 32 and 60 days after tamoxifen-induction ( scl CreERt/JAK2+ /V617F ). Platelet functions were analyzed in vitro by flow cytometry and light transmission aggregometry, ex vivo by measuring thrombus formation in whole blood and flow conditions on collagen and vWF, and in vivo in a FeCl3-induced model of thrombosis.

The analysis of platelet glycoprotein expression was focused on two ITAM receptors, GPVI and CLEC2. The principal observation is a deficiency in GPVI up to 50% in vav Cre/JAK2+ /V617F mice (p<0.01) while expression of other platelet membrane glycoproteins (GPIb, GPV, GPIIbIIIa and CLEC2) was normal. GPVI deficiency was confirmed by immunoblot while the expression of the FcRg chain was normal. At arterial shear rates, platelet adhesion and aggregation on immobilized collagen and vWF were profoundly impaired with a platelet surface coverage decreased by up to 80% (p<0.01). In vivo, an enlargement of mesenteric vessels was noticed in vav Cre/JAK2+ /V617F mice. When vessels of the same caliber as WT mice were submitted to FeCl3-induced thrombosis, platelet aggregates formed rapidly (5-8 min) but surprisingly occlusion was not often reached and the aggregates were highly unstable.

In scl CreERt/JAK2+ /V617F mice, GPVI deficiency was not observed at day 7 and 14 but appeared at day 60 after JAK2V617F-induction by tamoxifen. In vivo , time to vessel occlusion and thrombus stability were initially (day 7 and 14) similar in KI and WT mice. However, the rate to which platelet aggregates formed and their stability became impaired at 32 days after JAK2V617F-induction.

In conclusion, these data demonstrate that JAK2V617F induces complex modifications of platelet functions including platelet GPVI deficiency, in vitro loss of collagen-induced aggregation and facilitation of in vivo thrombosis initiation associated with instability of the clot. Therefore, this study provides new insight into the pathophysiology of hemostatic disorders in MPN, thrombus instability being able to drive microvascular thrombosis disorders and pulmonary embolism.

Disclosures: No relevant conflicts of interest to declare.


Objective
To investigate the effect of rapid intraosseous infusion rehydration combined with deep venous catheterization in patients with acute hypovolemic shock.

Methods
A retrospective analysis was conducted, which included 127 patients with hypovolemic shock treated in emergency room from March 2014 to March 2017. There are 79 males and 48 females, aged from 5 to 81 years old, average age (37.4±5.6)years. After each patient was admitted to the hospital, an intraosseous infusion channel was quickly established for rapid rehydration, followed by deep venous catheterization to continue expansion of blood volume. The control group of 116 patients with hypovolemic shock did not receive intraosseous infusion. The success rate of anti-shock treatment and the time of deep vein catheterization were compared between the two groups.

Results
Of the 127 patients, 10(7.87%) were dying on admission due to severe trauma and died after being rescued, and the other 117 patients (92.13%) survived in the hypovolemic-shock period and were admitted to the relevant specialties for further treatments. There were no hematopoietic dysfunction, myelitis or catheter-related infection of the deep vein catheter in the other patients during the 6 month follow-up. The successful rate of resuscitation by intraosseous infusion was better than that of the control group. There was no significant difference in the time of deep vein catheterization.

Conclusions
Combination of intraosseous infusion and deep vein catheterization is of great value forhypovolemic shock patients in the emergency.

Key words:
Hypovolemic shock; Intraosseous infusion; Deep vein catheterization


Simple Summary Mechanical ventilation is mandatory during ophthalmological surgeries when neuromuscular blocking agents are used. Ventilation of paediatric patients is more complicated because of their small size, the underdevelopment of their respiratory system and the lack of evidence-based guidelines for this age group. We presented two cases of severe hypoventilation during anaesthesia in paediatric dogs due to inadvertent ventilation mainly of the upper airways, and possible development of lung collapse. Both patients were ventilated using the same ventilator in a volume-controlled mode, and the actual level of hypercapnia was detected only when manual ventilation was used, and alveoli were properly ventilated. Adjustments in the volume-controlled ventilation failed to ventilate effectively, and manual ventilation was used for the remainder of the procedure until recovery. Both patients recovered well. Pressure-controlled ventilation, ventilators that take into consideration the compliance of the breathing system and the use of manual breathing, among other techniques, could contribute to better ventilation of those patients. Abstract A 2-month-old male 1.56 kg Yorkshire terrier (Case No. 1) and a 3-month-old male 2.3 kg Jack Russell Terrier (Case No. 2) were scheduled for ophthalmological surgery under general anaesthesia and neuromuscular blockade. For both patients, volume-controlled ventilation (VCV) was used with set tidal volumes (VT) of 13 mL/kg and 20 mL/kg for cases No. 1 and 2, respectively. The type of ventilator used did not take into account the intrinsic compliance of the breathing system; therefore, a significant part of the delivered VT was wasted in the expansion of the breathing system, and did not reach the patients, causing alveolar hypoventilation. Both cases developed low dynamic compliance (CD), and after a recruitment manoeuvre, EtCO2 of up to 116 mmHg and 197 mmHg were revealed for cases No. 1 and 2, respectively. The two cases had to be ventilated manually, using positive inspiratory pressures (PIP) of 20–25 mmHg, in order to improve alveolar ventilation and reduce the EtCO2, as adjustments to the VCV were ineffective. Both patients maintained an oxygen haemoglobin saturation between 94% and 100% throughout the procedure and they recovered well. Using a higher VT from the beginning, to compensate for the compliance of the breathing system, or the use of pressure-controlled ventilation (PCV), could have potentially helped to avoid these two incidences of severe hypercapnia.


Abstract : A wide variety of meteorological data was reduced and analyzed and the resulting techniques, programs, and procedures appear in this Final Report. The sections are as follows: Numerical Integrations; Meso-Scale Archive and Products of digitized Video Data from ESSA Satellites; Analysis of Radiosonde Field Test Data; Objective Mesoscale Visibility Techniques; Operational Procedures in Solving the Nesting Problem; Analysis of Micrometeorology Data; A Numerical Forecasting Model for Operational Use in the Tropics; Stratospheric Environmental Quality.


There were taken and analyzed electron-microscopic images of quartz particles after mechanochemical processing in mill-activator with different organic modifiers. It was stated that quartz surface suffers serious changes the peculiarities of which are defined by used modifiers. Quartz particle has a complex flaky morphology. Friable surface layers represent as carbonic element-organic formations with ferrous additives. The change of particle's surface layers are responsible to modified quartz physicochemical properties transfer.


Organizational ambidexterity that has been applied widely is currently taking shape as a research paradigm in organi zational theory.However,decentralization of existing research has hindered the development in depth of the theory.Based on that,this paper puts forward a multilevel integrated framework model for organizational ambidexterity,and analyzes some main theoretical hypotheses of the model.The paper also points out a direction of the empirical studies in the future.


Mashup is a representative of Web 2.0 technology that needs both convenience of cross-domain access and protection against the security risks it brings in. Solutions proposed by prior research focused on mediating access to the data in different domains, but little has been done to control the use of the data after the access. In this paper, we present Mash-IF, a new technique for information-flow control within mashups. Our approach allows cross-domain communications within a browser, but disallows disclosure of sensitive information to remote parties without the user's permission. It mediates the cross-domain channels in existing mashups and works on the client without collaborations from other parties. Also of particular interest is a novel technique that automatically generates declassification rules for a script by statically analyzing its code. Such rules can be efficiently enforced through monitoring the script's call sequences and DOM operations.