The appearance of detergent-solubilized voltage-regulated sodium channel protein was recently characterized by this laboratory. Negative- staining revealed rod-shaped particles measuring 40 X 170 A. Further studies have suggested that the actual configuration of this protein may be quite different from the rod-shaped structures. Freeze-fracture and freeze-etch images of the protein in reconstituted membranes indicated that the channel is cylindrical with a diameter of 100 A and a minimum length of 80 A. Experiments with two detergent systems (Lubrol-PX and sodium cholate) enabled us to explain the discrepancy between this structure and the rod-shaped particles visualized earlier. Negative staining in either detergent at low pH (4.5) produced rod- shaped structures. As the pH was increased, doughnut-shaped particles, consistent with the structure of the protein in freeze-etch, appeared in negative stain. The tendency of the protein to change shape under different pH conditions appears to be a peculiar property of this protein.


In large circuits, we are confronted with two problems. First, the modelling of integrated circuit modules using the normal methods of considering each element such as the general circuit analysis program---precise though it may be---can be excessively lengthy and tedious because of the computation time involved and the large storage required. On the other hand, since most very large circuits are likely to be active, and therefore nonlinear, and since the processes of non-linear analysis are more time-consuming than the corresponding processes of linear analysis, the time required for the inversion of these large matrices would become an even smaller proportion of the total. Though suitable for discrete circuit analysis, this method applied to integrated circuit configurations such as modified TTL and DTL gates leads to complex forms of modelling rendering it inappropriate for use in large systems consisting of hundreds of logic gates. Also, since the models of the elements constituting integrated circuits are more complex in nature than their discrete counterparts, a model leading to accurate predictions of performance will tend to give an excessively lengthy analysis. The choice of models becomes even more critical as the complexity of integrated circuits becomes larger. Even with the recent advances in sparse matrix, adjoint and implicit integration techniques, these methods are not powerful enough to solve the problems associated with large complex logic systems.


Objective To raise the detection rate of the antibody of hepatitis C virus (anti-HCV) and the accuracy of test results.Methods HCV ELISA reagents produced by two manufacturers(reagents① and reagent ②) were used to test the 2 516 serum samples from patients before surgery.Then 28 serum samples (both reagents positive),15 samples (only reagent ① positive) and 17 samples(only reagent ② positive) were tested on HCV RNA by RT-PCR quantitative fluorescence.Results 28 samples which were positive to both reagents were RT-PCR positive,while only 2 of the 15 samples which were positive to only reagent ① were RT-PCR positive and 3 of the 17 samples which were positive to only reagent ② were RT-PCR positive.In the latter 32 samples,HCV RNA RT-PCR positive rate was 15.63%.Conclusions Double-reagents detection can enhance the anti-HCV detection rate and the accuracy of the results.


DSTO has developed low cost re-configurable virtual simulators which were initially used to explore integration of armed reconnaissance helicopters into the Australian Army command and control environment. The availability of the simulators has been exploited by DSTO's operations analysis community as a means of exploring other armed reconnaissance helicopter issues. Meeting their needs has led to further development of the simulators to incorporate night flying, some rudimentary electronic warfare systems, and aids to data collection and reduction. This paper reports on current progress and looks to areas of future development. The paper concludes with some observations on requirements for the transition from DIS to HLA as a simulation paradigm to assist with similar activities


After almost a decade of basic science research on the Emotional Availability Scales, an intervention program based on the assessment instrument was developed. The intervention involves the training of parents and professional development for child care providers regarding attachment concepts and emotional availability, including both informational and experiential components. This paper describes the professional development program for child care professionals of infants and toddlers who are in child care centers at least 20 hours a week. It was proposed that attachment and emotional availability training for child care professionals would enhance their professional development related to children and improve the relational and emotional atmosphere of center-based care. The biological basis for attachment is the instinct to survive and seek protection during the vulnerable stages of infancy and early childhood. Thus, according to Bowlby (1980), attachment behaviors are observed across all cultures and throughout an individual's development. Approximately 70% of infants are secure in their attachments with their parents, while 30% tend to be insecure. These percentages apply to all economic backgrounds, cultural groups, mothers, and fathers in the United States (Bakermans-Kranenburg, van Ijzendoorn, & Juffer, 2003; Biringen, 2004). Researchers have studied attachment relationships for over 40 years, with the focus primarily on mothers (Biringen, 2004). Infant attachment security to the mother has been found to be predictive of later positive affect with preschool classmates and competence in school-age peer interactions (e.g., ego-resiliency, popularity with classmates, less social anxiety) (Bohlin, Hagekull, & Rydell, 2000; Waters, Wippman, & Sroufe, 1979). Securely attached infants and their mothers also show more positive interactions during joint book reading than insecurely attached infants (Bus & van Izjen doorn, 1992). Importance of Child Care Professionals as Attachment Figures and Relationship Partners Almost two decades ago, Goosens and van Ijzendoorn (1990) indicated the importance of caregivers other than the mother as attachment figures. Calculations from the 1999 National Survey of America's Families (NSAF) show that approximately half (48%) of mothers were in the workforce full-time (Urban Institute and Child Trends, 1999). Currently, 39% of children in the United States, and 36% of children under the age of 3, are spending 35 or more hours in center-based child care per week. Given the large numbers of infants in child care and particularly those who are at least half-time in child care, the quality of relationships with not only the mother but also with the child care provider becomes a particularly important area of investigation. Child care providers spend considerable amounts of time with the children in their care, and these relationships may offset varying social risk factors, such as teen parenting, caregiver chemical dependency, domestic violence, and/or parenting practices that are associated with negative child outcomes. Under such circumstances, child care providers may serve as a buffer to the primary attachment relationships with parents and thereby enhance a child's overall adjustment. In addition, child care providers may be able to partner with parents in an emotionally connected way and even provide role modeling for optimal adult-child interactions (Marty, Readdick, & Walters, 2005; Spieker, Nelson, Petras, Jolley, & Barnard, 2003; Zimmerman & Fassler, 2003). In fact, among children not securely attached to their parents, Howes and her colleagues report compensatory attachments to teachers (Howes, Rodning, Galluzzo, & Myers, 1988). Further, research supports the assertion that relationships with child care providers/teachers can predict children's social-emotional development. For example, Howes, Hamilton, and Matheson (1994) found that for children in child care, attachment with child care providers/teachers was a better predictor of peer relationships than attachment to mothers. …


Smuggling of very important trees such as Sandalwood in forests and also a forest fire poses a serious threat to forest resources which results significant economic damage and ultimately has quite a destructive effect on the environment all over the world. To limit their sneaking and to spare Woodlands around the world some preventive estimates should be conveyed. This survey paper proposes different technologies used for anti-poaching system.


Analyzed is the influence on the precision of optical flow algorithms taken by the offset between the two frames.The precision declines with the increasing offset between the two frames.In this view,a novel optical flow detection solution based on background registration is proposed.This solution calculates the approximate offset between the two frames using background registration and further calculates the comparative optical flow based on the offset,which helps to ensure a good input for optical flow algorithm and improves the precision.The final optical flow filed is synthesized by the accumulation between approximate background offset and comparative motion vectors.Experimental results show the proposed solution has better performance in the precision than the classical solution without background registration.


In DC ion beam tandem accelerator facilities commonly Helix Rotating wire Beam Profile Monitors/scanners (BPM) are used to monitor the shape and location of the ion beam. These BPMs are used in combination with a BPM Selection station which activates and conditions signals visualisation on an Oscilloscope. At ANSTO we have been developing an alternative system to allow firstly the management and operation of concurrent National Electrostatics Corp (NEC) BPMs, secondly to construct a 2D approximation of the particle beam parameters based on programmable hardware and software, and thirdly to give advanced functionality to control systems. This paper will review the current status of the development, and the potential features which can be gained with this technological approach.


Considering the organizational learning and commitment of individuals as contributing factors to the success of public and private organizations, the study sought to better understand the integration of these constructs in an IHE - Institution of Higher Education. In order to achieve the overall goal that was to: analyze the relationship between commitment and organizational learning in a public institution of higher education we conducted a survey with a sample of 116 valid statutory employees of a HEI. Two questionnaires of self report were used, the Organizational Learning Scale (OLS) of Goh and Richard (1997), that was validated in Brazil by Angelim and Guimaraes (2003), and the instrument of Meyer, Allen and Smith (1993), validated in Brazil by Medeiros and Enders (1998), in the administrative and support sectors of the organization. It was concluded that the more committed employees are, the greater the perception of favorable factors to learning and consequently the greater the chances that such scenarios will actually stimulate the organizational learning. The study highlights the importance of investing in the potential factors of learning and identifying the components of commitment, in order to improve the internal processes, as well as the learning capacity of the organization as a whole.


Background: The use of ionizing radiation has led to advances in medical diagnosis and treatment. Objectives: The purpose of this study was to determine the risk of radiation cataractogenesis in the interventionists and staff performing various procedures in different interventional laboratories. Patients and Methods: This cohort study included 81 interventional cardiology staff. According to the working site, they were classified into 5 groups. The control group comprised 14 professional nurses who did not work in the interventional sites. Participants were assigned for lens assessment by two independent trained ophthalmologists blinded to the study. Results: The electrophysiology laboratory staff received higher doses of ionizing radiation (17.2 ± 11.9 mSv; P < 0.001). There was a significant positive correlation between the years of working experience and effective dose in the lens (P < 0.001). In general, our findings showed that the incidence of lens opacity was 79% (95% CI, 69.9-88.1) in participants with exposure (the case group) and our findings showed that the incidence of lenses opacity was 7.1% (95% CI:23-22.6) with the relative risk (RR) of 11.06 (P < 0.001). Conclusions: We believe that the risk of radiation-induced cataract in cardiology interventionists and staff depends on their work site. As the radiation dose increases, the prevalence of posterior eye changes increases.


SLA(Scanned Linear Array) is a portable display unit for implementing next-generation virtual realities, utilizes a design that light generated by a line of LEDs is reflected from the rapidly oscillating mirror to generate a raster display. Reaction forces generated by the motions of the mirror and counter-balance mass cancel each other at the device base, reducing vibration. Metal leaf springs have been extensively applied in such portable units. Magnetic springs have been developed and adopted that can replace the metal spring and can avoid many disadvantages of metal springs. We model and analyze the dynamics of the structure with magnetic springs and present the simulation and experimental analysis results, which can be utilized for identifying and eliminating possible problem sources in removing shaking forces and moments, and oscillating the mirror at the required amplitude and frequency. Finally, we present the improved novel magnetic actuator model which can be applied in portable display units.


Increases in allergic diseases have been well documented worldwide. Approximately one-third of children with severe atopic dermatitis (AD) were reported to suffer from IgE-mediated food allergy as well. Data sources concerning the food allergy, AD, and atopic march were accessed from Pubmed/MEDLINE. This review provides a summary of findings concerning the food allergy, food hypersensitivity reactions, and atopic march in children and adolescents. Food allergy that developed at a young age increased the risk for AD, asthma bronchiale, and allergic rhinitis; new research identifies the skin barrier as not only an important initiator of AD but it may even be a site for allergic sensitization to protein antigens. Early childhood is thought to be a key period for the prevention of allergic march and adolescence is another key period for the prevention of recurrence. The prevention of recurrence would decrease allergic disease in adulthood.


To elucidate the cytotoxic induction mechanisms of the hydrophilic HEMA, the comparative cytotoxic activities of HEMA and the hydrophobic monomers TEGDMA and MMA were studied, using erythrocytes, gingival fibroblasts and a salivary gland carcinoma cell line. Also, the gel-to-fluid phase transition properties (i.e. temperature, Tm; cooperativity, H/HHW; enthalpy, ΔH) of dipalmitoylphosphatidylcholine (DPPC) and DPPC/cholesterol (CS) liposomes (as a model for biological membranes) induced by methacrylates were investigated, using differential scanning calorimetry (DSC). In addition, the methacrylate-chemical-shifts in DPPC liposomes were assayed using NMR spectroscopy. Both the hemolytic and cytotoxic activity declined in the order: TEGDMA> HEMA>MMA. The changes in Tm increased in the order: HEMA >TEGDMA, while in contrast, that of HEMA was slightly increased without changes in the ΔH. The DSC changes in DPPC/CS liposomes with HEMA were the largest of those recorded. The cytotoxicity of HEMA may be induced by the hydrophobic interaction derived from the molecular association of OH groups of HEMA and, in addition, by the preferential interaction with CS.


Coalescence of precipitates is a common kinetic phenomenon. The phase-field method can simulate coalescence of precipitates without any ad hoc assumptions. However, independent of long range effects (e.g. lattice misfit) the method predicts a high coalescence rate when applied to systems with a high volume fraction of precipitates. We show that this is a result of ignoring the local phenomenon in the interface regions, which is an approximation adopted by many other simulation techniques. An improved coalescence rate is achieved by properly addressing this local phenomenon through introducing composition and phase dependence of diffusion mobility.


An embodiment of the invention provides a TCP (transmission control protocol) data transmission method and a TCP unloading engine and system and relates to the field of communication. The method includes: the TCP unloading engine receives TCP data transmitted by remote equipment; TCP unloading is performed on the TCP data; the unloaded TCP data is identified and transmitted to a CPU (central processing unit) or a storage device corresponding to the storage position information issued by the CPU. By the TCP transmission method applicable to TCP data transmission, data moving between the TCP unloading engine and the CPU can be reduced, data analyzing work of the CPU can be reduced, and TCP/IP (Internet protocol) data resources processed by the CPU is reduced, and transmission delay is reduced.


Complex and decentralized information systems need advanced communication services at the middleware level in order to leverage context-aware distributed applications working, for example, despite node mobility and in a setting where such services can be billed. In this paper, we present a middleware architecture offering a communication service which, in its more general case, is able to provide connectivity between two nodes belonging to distinct mobile ad-hoc networks by taking user profiling into account. The proposed architecture is based on a resource awareness service enabling dynamic resource discovery and composition despite the assumed heterogeneity of the ad-hoc networks building the system.


Life cycle theory is an important method to analyze the impact of industrial environment,and it is one of the core research contents for industrial ecology. With the emerge and development of " low carbon tourism",the concept of tourist carbon footprint( TCF) was put forward by many scholars. In this research a model about life cycle analysis of tourist carbon footprint( TCF-LCA) was built combining the periodic characteristics of tourist activities and LCA theory,and an empirical analysis on Hebei Yesanpo scenic spot was taken. The conclusion shows that TCF-LCA model is a good method to measure and compare the tourist carbon footprint,and is a tool for low carbon tourism management. This measure method will be helpful to guide tourists' choice of low carbon tourism. At the same time it also has an important theoretical value and a reference meaning to the planning and construction of low carbon tourism destination and low carbon tourism product development.


The complete high‐order perturbation formulas based on a two‐mechanism model for the spin‐Hamiltonian (SH) parameters (g ‐factors g||, g⊥, and zero‐field splitting D) of 3d3 ions in trigonal octahedral sites are derived. In the model, not only the conventional contribution to SH parameters from the crystal‐field (CF) mechanism, but also that from the charge‐transfer (CT) mechanism (which is omitted in the CF theory) are included. From these formulas, the SH parameters of Mn4+ replacing Al3+ in Al2O3 crystal are calculated by using the parameters related to the optical spectral data and the defect structure of the studied system. The results (including the relative importance of the CT mechanism on the SH parameters and the defect structure of Mn4+ impurity center) are discussed. (© 2008 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)


Summary Field experiments were conducted from 1991 to 1993 to determine the critical period of weed control in chilli pepper. The maximum weed-infested period ranged between 0.7 and 3.2 weeks after transplanting (WAT) at a 5% yield loss level. To prevent losses in total and marketable yields, weeds should be removed 2.1 or 0.9 WAT respectively. The end of the critical period decreased as the predetermined yield loss level increased from 2.5% to 10%. The minimum weed-free period ranged between 6.7 and 15.3 WAT at a 5% yield loss level depending on crop yield category. The chilli pepper crop required an average of 12.2 weeks of weed-free maintenance to avoid losses above 5%. Using a 5% yield loss level, the duration of the critical period of weed control was 14 weeks in 1991 and 11.2 weeks in 1993, but was shortened to 5.1 weeks in 1992. The results suggest that weeds must be controlled during the first half of the crop's growing season in order to prevent yield losses.


According to the rapid development of the road construction,the author analyzes the cause of the pavement rack in Beijiang in Xinjiang,and puts forward the preventive measures of the pavement rack,to accumulate the construction experience of the road and ensure the road engineering quality and prolong the service life of the road.


Based on Law No. 34 of 2004, the Indonesian Navy has the main task of maintaining state sovereignty in territorial waters. Various attempts have been made to strengthen the Navy so that it can carry out these basic tasks, one of which is to add defense equipment, namely ships that have the ability to shoot missiles. This missile possession is important because in addition to being a deterence effect, modern naval battles are dominated by long-distance warfare or Over The Horizon. In missile fire, accurate intelligence is needed to determine the position of the target. So far what has been done is sending submarines or reconnaissance aircraft. This is very inefficient because in addition to requiring large resources, the risk of losing personnel and material is also very large. Based on this, the researcher makes a prototype of a vehicle that can identify and determine the position of a target. The vehicle in the form of a UAV is equipped with GPS, altimeter, compass and camera. This equipment will provide data in the form of UAV latitude and longitude position, UAV height, UAV heading and UAV camera angle. From the four data above, the ground station on themissile carrier gets the target's latitude and longitude data based on image processing. While the method used is color thresholding which can distinguish a target based on its color. After several trials, the UAV has been able to carry out the target positioning up to a height of 15.4 meters. At these heights the target latitude can be determined with a system accuracy of 3.3 meters. To be used as a reference for missile firing, it is necessary to increase the capability of the equipment specifications to reach the desired distance.
Keywords: Target, Latitude, Longitude, Image Processing.


Permanent magnet synchronous motor is the most drive motor of electric cars, to solve the problem of permanent magnet synchronous motor without position sensor speed control system has speed detection delay, error detection, slow dynamic response etc. The speed of sliding mode observer for permanent magnet synchronous motor used in electric vehicles, analyzes the structure and principle of sliding mode observer, combined with the mathematical model of PMSM, the design of electric vehicle speed sliding mode observer for permanent magnet synchronous motor. The simulation speed of sliding mode observer designed by MATLAB, the simulation results show that the speed of sliding mode observer for permanent magnet synchronous motor in electric vehicle design has the advantages of fast detection speed, small detection error, fast dynamic response etc


This research explains the context in which General Valery Gerasimov's often cited article, "The Value of Science Is in the Foresight: New Challenges Demand Rethinking the Forms and Methods of Carrying Out Combat Operations" published February 26, 2013, in Military-Industrial Courier was written. Furthermore it explains why "Gerasimov's Doctrine" is not a new Russian development, but is a response to the West's new way of war, and description of the future of war in general.


The immune system participates in the Angiotensin II (AngII)-dependent hypertension (HTN). Dendritic Cells (DCs)-CD11c
 +
 and macrophages (Mo) are abundant in the kidney. However, new subpopulations of CD11c
 +
 cells with Mo characteristics (F4/80
 +
 ) have been described. Recently, studies have shown that type-1 AngII receptor (AT
 1
 R) in CD11c
 +
 cells could have a protective effect on HTN in contrast to the pro-hypertensive effects of AT
 1
 R activation in other cells. Here, our goal was to evaluate whether renal Mo (rMo) modify their phenotype during AngII-induced inflammatory kidney damage, and whether their transfer to normotensive animals promotes HTN in an AT
 1
 R-dependent manner.

 Male C57BI/6 mice (10 weeks, n=6) were infused with AngII (490 ng/kg/min), AngII+Losartan (LOS; 20mg/kg/d, in drinking water), or vehicle (Vh) for 14-days. Systolic blood pressure (SBP) was measured by plethysmography. Renal DCs (rDCs, CD11c
 +
 F4/80
 -
 ) and rMo (CD11c
 +
 F4/80
 +
 ) were evaluated by flow cytometry and isolated at 14-days for the transfer to normotensive mice, which were followed for 7-days (n=4-5). Finally, rDCs and rMo were stimulated
 in vitro
 with AngII (100nM, 24h) to analyze the mRNAs abundance of AT
 1
 R. All data are presented by mean±standard deviation.LOS prevented the SBP rise (AngII+LOS=110.3±11.1
 vs.
 AngII=134.7±6.9 mmHg; p<0.01) and the increase of rDCs population (AngII+LOS=12.8±2.0%
 vs.
 AngII=16.5±0.6%; p<0.01) induced by AngII, without changing rMo population. The rMo transfer from AngII mice did not induce HTN in normotensive animals after 24h (basal=106.8±2.3
 vs.
 112.4±4.9 mmHg; ns), compared to rDCs (Basal=110.0±8.3
 vs.
 132.0±14.3 mmHg; p<0.05). However, the rMo from AngII+LOS mice increased SBP in healthy animals compared to their baseline (basal=109±5.6
 vs.
 123±8.0 mmHg; p<0.05). This effect was not observed by rDCs transfer (basal=109±2.9
 vs.
 113±7.0 mmHg; ns). Finally, the rMo from AngII mice showed an increase in the AT
 1
 R mRNA abundance (p<0.05), compared to Vh rMo, however, AngII
 in vitro
 treatment did not modify the mRNA levels.The
 in vivo
 AT
 1
 R antagonism may have a differential effect on rMo, transferring HTN to normotensive mice. These findings suggest that subpopulations of renal CD11c
 +
 cells have a differential role in HTN.Fondecyt 1231909


In this paper, we present a novel layered saliency model for Light Fields (LF) called Fourier Disparity Layer Saliency Estimation (FDLSE). The layers are constructed from the existing Fourier Disparity Layer (FDL) LF representation. Our FDLSE model can be used to predict the visual attention (VA) of any LF rendering with arbitrary viewpoint, aperture and depth-of-focus, without the need to generate the rendered image itself. The proposed model surpasses previous work in the following areas. Our method requires the estimation of the saliency map of only one sub-aperture image instead of the full view array. Furthermore, this model does not require pre-estimated disparity maps, but instead relies on the FDL model whose computation fully takes advantage of GPU parallelisation. Finally, FDLSE shows visual improvements and performs quantitatively on par with our previous FGSE model when evaluated on VA prediction of refocus renderings. To our knowledge these are the only two models which can be used to predict LF VA.


We propose a structural path for the icosahedra<->fcc transition in clusters and demonstrate the transition in Pb_13 by ab initio molecular-dynamics simulation. The proposed path can be described by using only two variables. The energy surface on this two-dimensional space for Pb_13 was calculated and a barrierless fcc-to-ico energy path was found. The atomic displacements of the proposed structural transition for ico and fcc Pb_13 were identified as one of the vibrational eigenmodes of the clusters with a soft mode for fcc Pb_13. These agree with the energy curvatures around the two structures, i.e. the ico Pb_13 is at the bottom of a valley on the energy surface while the fcc Pb_13 is at a saddle point. The barriers of this transition for larger clusters of Pb_n (n=55, 147 and 309) were also calculated, by ab initio elastic-band method, and found being smaller than the room-temperature thermal energy.


If the Real-Time Computer is the heart of an AO system, the Wavefront Sensor (WFS) its eyes, the Deformable Mirror (DM) its hands and the control strategy its nervous system, the sum of all those parts is made into a harmonious entity thanks to calibrations. This paper does not have the ambition to provide an overview of all the currently existing calibration strategies, but rather to focus on a few challenging problems and their recent evolution in the era of adaptive telescopes, mostly based on the experience of ESO's Adaptive Optics Instruments in general and the AO Facility in particular. Single most important calibration in post-focal AO system, the recording of the Interaction Matrix (IM) between WFS and DM has since long evolved to use fast modulation techniques, has shown to be feasible on-sky and is now almost free from measurements thanks to its pseudo-synthetic generation, quasi-mandatory solution in an adaptive telescope. Pseudo- because it requires an unprecedented knowledge of the components' characteristics, especially the WFS, DM and the optical registration between the two. Bigger telescopes and the use of Laser Guide Stars (LGS) also mean that the properties of the system will change in time and thus need to be constantly updated thanks to online diagnosis tools for spot size measurement, atmosphere monitoring, Wavefront Sensing and control optimization. New loops come into play like the one to minimize LGS Jitter and the one taking over the telescope active optics by means of offloading the DM low orders, and they all require calibration. More calibration means more time and one has to carefully balance the calibrations that require precious telescope night time, day time or for the best, no telescope time at all. Their importance sometimes underestimated, calibrations have repeatedly shown to be a vital part in the optimum functioning of present and future AO systems.


In psychology, "joint attention" is defined as the focus of two individuals on an object which is mutually acknowledged as a shared interest. Using google scholar to search the articles information related to the "joint attention" including the title, subject and author etc and then download the records. The dataset include articles information in three domains which are child psychology, robotics and HCI.


Objective:To investigate the change of the trans-fatty acid(TFA)of erythrocyte membrane in hypercholesterolemic patients(HC)by the influence of rosuvastatin treatment.Method:The fasting serum lipids and 22 kinds of FA were determined in 30 HC patients before and after 4 week rosuvastatin treatment,and in 30 ortholiposis patients selected as control group.The TFA and cis-FA(CFA)of C18∶1 and C16∶1 were determined separately.Result:① Compared with control group,HC group had significantly higher SFA and MUFA but obviously lower PUFA.② C18∶1 and C16∶1 were obviously higher,but the ratio of t18∶1/c18∶1 increased,and the ratio of t16∶1/c16∶1 decreased;The treatment restored the t18∶1 and t16∶1 content and the ratios of t18∶1/c18∶1 and t16∶1/c16∶1.③The ratios of C20∶4/C18∶2,C20∶5/C18∶3 and C22∶6/C20∶5 of HC group were obviously lower than those of control group before treatment and increased significantly after treatment.Conclusion:①Rosuvastatin effectively normalizes not only the content of FA in erythrocyte membrane,but also the ratio of TFA/CFA of c18∶1 and c16∶1.②Rosuvastatin effectively restores △5 and △6 desaturase activity index.


Objective:To investigate the value of urine epidermal growth factor(EGF) concentration in early diagnosis of Henoch-Schonlein Purpura nephritis(HSPN) in children.Methods:Bi-antibody ELISA was used to measure urine EGF levels in 91 HSP and 30 healthy children.Results:(1)The urine EGF concentration in HSP patientswas significantly higher than that of control group [(78.59±18.09)μg/L vs(29.30±13.92)μg/L,P0.01].(2)Urine EGF concentration in purpura nephropathy [(89.31±17.68)μg/L] was significantly higher than that in any other types: skin type([(78.76±12.66)μg/L],) abdominal type [(77.16±11.77)μg/L],joint type [(76.49±17.45)μg/L] and mixed type [(77.71±13.49)μg/L] all P0.05),but there were no statistical significance among the latter four types(both P(0.05).)Conclusion:The concentration of urine EGF increases in HSP chidren,especially in early stage of HSPN.The increase of EGF level may be associated with pathological change in HSP.Urine EGF level can be used as one of sensitive indictors in early kidney damage of HSP.


Hsp27 is constitutively expressed and increases in response to stress. Pretreatment of LLC‐PK1 cells with 11‐deoxy‐16,16‐dimethyl PGE2 (DDM‐PGE2) selectively increases constitutive Hsp27 expression and contributes to protection against 2,3,5‐tris(glutathion‐S‐yl)hydroquinone (TGHQ) induced cytotoxicity. We have now identified specific changes in Hsp27 phosphorylation during DDM‐PGE2 mediated cytoprotection. 2D gel electrophoresis revealed that in addition to constitutive pS15‐Hsp27, TGHQ induces the formation of 2 additional Hsp27‐positive proteins. 2D western analysis subsequently identified TGHQ induced pS84‐ and pS88‐Hsp27, both of which are translocated to the nucleus. Pretreatment of LLC‐PK1 cells with DDM‐PGE2 increases the constitutive expression of pS15‐Hsp27 in the cytosol and the nucleus, and specifically decreased TGHQ‐mediated induction of pS84‐Hsp27. These findings were confirmed by mass spectrometric analysis. Interestingly, although the inhibition of p38 MAPK prevented TGHQ‐induced pS84‐Hsp27 phosphorylation and cytotoxicity, transfection of cells with mutant Hsp27 (S15,84,88→ A15,84,88) or p‐Hsp27 (S15,84,88→D15,84,88) had no effect on TGHQ‐induced cytotoxicity. The data suggest that the specific phosphorylation of Hsp27 at Ser84 negatively regulates cell survival, and that pS15‐Hsp27 may be positively associated with cell survival. (GM56321, ES06694).


The ongoing COVID-19 pandemic has caused a paradigm shift in all aspects of contemporary human life. Everyday activities such as shopping have shifted from traditional methods to the ever-more growing online variants, allowing for an increase in electronic commerce (e-commerce) industry. As more services become available online, consumers often rely on trusted services, which are often reflected on the web and mobile platforms they are presented on. In this paper, we study the factors for successful e-commerce platform design in the Western Balkans region using Fuzzy Analytical Hierarchy Process (FAHP) with triangular fuzzy numbers. After an extensive literature overview, interviews with representatives of top-ranking e-commerce companies in the region, and the analysis of experts' opinions, we select a number of factors and sub-factors for prioritization, taking into account pre-pandemic factors, as well as the ones of the pandemic itself. We extend the FAHP model, which now consists of five (instead of three) points of view. Finally, we present and discuss the results in the form of tables and graphs, as well as an overall recommendation of what should be taken into account when designing an e-commerce platform. Our results rank service quality and security factors first and criteria such as multilingual support last.


Using the non-local empirical pseudopotential method (bandstructure), full-band Monte-Carlo simulations (transport), self-consistent Poisson-Schrodinger (electrostatics) and detailed band-to-band-tunneling (BTBT) (including bandstructure and quantum effects) simulations, the effect of surface/channel orientation, uniaxial- and biaxial-strain, band-structure, mobility, and high-field transport on the drive current, off-state leakage and switching delay in nano-scale, strained-Si and strained-Ge, p-MOS DGFETs have been presented and the optimum strain and channel/surface orientations for highest drive-lowest delay-lowest leakage have been obtained.


Carbon−oxygen bond-forming reductive elimination from transient Pd(IV) aryl/acetate complexes was recently implicated as the product release step in Pd(II)-catalyzed arene oxygenation reactions. The mechanistic details of C−O bond formation from these Pd(IV) intermediates remain elusive and, therefore, are subjected to a systematic theoretical investigation in the present study. Three proposed mechanisms are examined including (A) pre-equilibrium dissociation of a benzoate ligand followed by reductive elimination from the resulting five-coordinate Pd(IV); (B) direct reductive elimination from the six-coordinate Pd(IV); and (C) dissociation of a pyridyl arm of one cyclometalated ligand followed by internal coupling. Through density functional theory calculations it is suggested that mechanism B is favored over the other two mechanisms. This conclusion is supported by the success of the theoretical model based on mechanism B to reproduce the experimental activation free energy barriers. The same theoretical...


We present explicit self-similar solutions for the two-dimensional plasma-ion sheath system in the plasma physics. We show that the self-similar solutions are consistent with numerical simulations of Sheridan (1996 Phys. Plasmas 3 2461–6).


Magnetophonon resonances have been observed in the warm-electron coefficient beta in n-GaAs, at temperatures between 55K and 77K. The resonances seen indicates a rapid change in importance of the energy relaxation processes involving LO phonons from impurity site capture at 60K to inter-Landau level transitions at 70K. The relative amplitudes of the different magnetophonon series was measured precisely by the use of Fourier analysis. The observed behaviour is interpreted in terms of a strong distortion of the electron distribution at energies one LO phonon distant from the donor ground state. At 77K it is found that high electric fields can change the sign of the extrema and also produce a small shift in the position of the extrema.


The invention relates to the field of cable equipment and particularly relates to small copper wire drawing equipment for a cable. The equipment comprises a machine body, a wire-releasing device, a wire-drawing device, a tensioning device, an annealing device and a take-up device, wherein the wire-releasing device is positioned on the left side of the machine body, the wire-drawing device is positioned in the middle part of the machine body, the tensioning device is positioned on the right side of the wire-drawing device, the annealing device is positioned on the right side of the tensioning device, and the take-up device is positioned on the right side of the annealing device. The small copper wire drawing equipment for the cable provided by the invention can realize a full course of automatic wire release, drawing, take-up and etc. of a copper wire, and is simple in structure and high in degree of automation.


Nowadays plenty of plant had been explored and widely used in crop disease control and fruits and vegetable fresh-keeping,such as Agastache rugosa,Sophora flavescens,Alpinia officinarum.Compared with traditional chemical fungicide,plant extracts had more expansive development value and market prosper with the characteristics of extensiveorigin,environmental,safe and effective,etc.Citrus is the largest yield fruit in the world,and many research have been done to develop botanical fungicide.Some plant extracts which had inhibition effects on citrus postharvest pathogens were summarized from three aspects which were in vitroinhibition,in vivo preservation effects and inhibition mechanism,along with some problems in the research and the development were analyzed and discussed.


The diamond wire saw was a promising cutting technology for silicon solar wafer production.Experiments of single diamond scoring of crystalline silicon and diamond wire saw slicing of crystalline silicon have been carried out.The micro-morphologies of the cut surfaces were examined.The results showed that,under higher pressure,crystalline silicon was cut by diamond wire saw in brittle model,with broken pits on cut surfaces,and brittle cleavage stripes in the case of single diamond scoring test;under lower pressure,crystalline silicon was cut by diamond in plastic model,with relatively flat and smooth scratches.On silicon wafers sliced by diamond wire saw,there were lots of irregular pits,along with extended smooth scratches on top of them,indicating the mixture of the brittle cutting mode and the plastic cutting mode.The reason may be that the pressure underneath the cutting wire was high,where the crystalline silicon was cut in brittle mode,while the exposed surface would inevitably be scratched by the diamonds on lateral sides of the wire saw,under a much lower pressure,which would cut the surface in plastic mode.Therefore,a cut surface characterized by a mixture of brittle and plastic cutting mode was generated by diamond wire saw slicing.


The paper examines methods of utilization of zeolite regeneration gases to assess the possibility of using them in an industrial adsorption unit for drying and purifying gases from hydrogen sulfide and mercaptans. The most promising is the method of decomposition of mercaptans to hydrogen sulfide and hydrogen on solid catalysts, which is carried out at a pressure and temperature of 200-350 °C, as well as the method of direct gas-phase catalytic oxidation of mercaptans with atmospheric oxygen. We carried out experiments on the purification of zeolite regeneration gases of the Orenburg GPP by oxidation with atmospheric oxygen using an iron oxide catalyst at a temperature of 180-250 °C. They showed that the gas purified from mercaptans contained elemental sulfur and disulfides as the main oxidation products, and 0.2% vol. of sulfur dioxide was present as a by-product. The method of purification from mercaptans and heavy hydrocarbon gases regeneration of composite adsorbent by thermocatalytic oxidation is also proposed. To reduce the yield of undesirable sulfur dioxide in the regeneration gas purified from mercaptans, it is proposed to divide the regeneration gas stream into two streams, while the larger part, comprising about 80-90% vol., is sent to oxidation on a zinc-iron catalyst at 200 °C, the second stream is mixed with oxidation products in a volume ratio in terms of mercaptans and sulfur dioxide equal to 1.5-2.2÷1, respectively, then the resulting mixture is passed at 160-200 °C through a titanium oxide catalyst with a gas volumetric velocity of 4000-6000 h-1. The proposed scheme for gas purification from mercaptans and heavy hydrocarbons on a composite adsorbent with oxidative regeneration makes it possible to carry out the subsequent process of amine purification of gas from hydrogen sulfide without the complications associated with foaming of the working solution. Furthermore, it becomes possible to transport gas purified from mercaptans and hydrogen sulfide through the pipeline without precipitation of condensate.


The internal law of the body mass indexes of the Chinese elite female rowers was explored. The main conclusions are as follows: 1)The body mass indexes of the Chinese elite female rowers reflect the general demands of the specific characteristics of physique and body type from them. That is the great and strong of stature with long and thin arms as well as brawny and strong thigh. 2)The Quetelet index (x1), girth of thigh index (x16), body height and chest girth indexes (x2) are able to reflect the comprehensive morphological level of the Chinese elite female rowers. The regression equation was established, which is more reliable and valid after checking. Hereby it is able to predict and evaluate the comprehensive morphological level of the Chinese elite female rowers. 3)There exists entirely significant difference in body mass indexes between the rowers of the open weight class and those of the lightweight class. 4)The distinguishing functions were established by using the Quetelet index, girth of thigh index (x16) as well as the body height and chest girth indexes as their variables. After the distinguishing check it was shown that the groups that the rowers subordinate to can be differentiated effectively by these functions and the rationality of the body mass indexes of the open class and lightweight class rowers can be evaluated.


The invention discloses a coating which has inexpensive cost, easy production, good effect of capturing neutron and excellent neutron radiation-proof effectiveness and which is composed of a neutron moderating layer and a neutron capturing layer, wherein, the neutron moderating layer is formed by mixing 50-60% of coating with 40-50% of neutron moderating additives by weight percentage, and the neutron capturing layer is formed by mixing 50-60% of coating with 40-50% of neutron capturing additives by weight percentage; the neutron moderating additive is formed by mixing graphite powder and lead oxide powder with the weight ratio of graphite powder to lead oxide powder being 3:1, and the neutron capturing additive contains the following components, based on percentage by weight: 30-50% of natural B2O3, 5% of aluminum powder and/or zinc powder, 5% of Fe2O3 and 20-35% of concentrated B2O3 with the abundance larger than 90%.


We demonstrate using PS-OCT to sense cross-sectional ECM nanotopology by mapping spatially resolved GNR diffusion. This novel approach will enable new applications in studying ECM remodeling such as tumorigenesis.


A stable phosphinous acid complex, H2P(OH)W(CO)5, was prepared by LiAlH4 reduction followed by acid hydrolysis of the corresponding diethylaminodichlorophosphine complex.


This paper proposes an efficient method called Exu-Eye for hard exudate segmentation in retinal funds images based on multi-scale modules and gated skip connections. The key components of Exu-Eye are (1) two multi-scale modules; the first one is at the beginning of Exu-Eye, while the second one, Atrous Spatial Pyramid Pooling (ASPP), is inserted at the neck of Exu-Eye to improve the fundus image feature extraction; (2) ImageNet MobileNet encoder; (3) Gated skip connection mechanism to enhance the capture of more details of retinal eye exudate lesions. Different experiments have been conducted on publicly available datasets, namely IDRiD and Ophtha EX, to demonstrate the efficacy of our method. Exu-eye obtained 75.53, 83.54, 79.33, and 87.5% of recall, precision, F1, and AUPR metrics on IDRiD and 59.25, 61.59, 60.40, and 64.53% on Ophtha_Ex dataset, respectively. Exu-Eye also outperforms numerous state-of-the-art approaches.


Aiming at the existing problems of the evaluation system of our country's state-owned enterprises,using the research achievements of the Western performance evaluation for reference,and considering the special features of those enterprises,the author thinks that to perfect the evaluation system of the performance for our country's state-owned enterprises shall start from these levels such as the theoretical basis of evaluation system for comprehensive achievement,the evaluation targets of intelligent assets added,and the importing achievement of the economic increasing value.


iological rhythms are cyclic changes which correspond to the temporal organization of the environment. The frequencies of the rhythms are synchronized by daily, tidal, lunar, and seasonal cycles that serve to adapt organisms to rhythmic environmental changes. They also, in the absence of signals such as light-dark cycles, enable organisms to anticipate cyclic events. Overt rhythms, for example activity-rest cycles, are often recorded under 24-hour photoperiods which synchronize them to a 24-hour day. They are thus entrained by the photoperiodic input. In contrast, activity-rest rhythms have also been documented under constant conditions, that is with no known periodic changes in the environment that could act as entraining agents (Zeitgebers). The cycles which persist under constant conditions with self-sustained oscillations are called endogenous rhythms. Endogenous rhythms become free-running with periods which deviate from environmental cycles, and because of this they are defined as circadian, circatidal, circalunar or circannual. These free-running rhythms have the unusual property of temperature compensation, that is stability of period over a wide range of physiological temperature^.'-^ Only by analyzing the properties of endogenous rhythms can changes in the biological oscillator driving the rhythms, the pacemaker, be determined. The properties of endogenous rhythms differ in older organisms as compared to young adults, suggesting that timekeeping systems are altered during aging. Many reports have provided evidence for the emergence of rhythmicity during development and changes during maturation, and these have been reviewed re~ e n t l y . ~ While one may argue that aging is a continuation of the developmental process, this review will be confined to studies of both entrained and freerunning biological rhythms in young adults and the changes in the properties of the rhythms during the adult life span.


The article presents the results of studies of the properties of carbon fiber of the VKU-51 brand and fiberglass of the VPS-58 brand, made on the basis of the epoxy vinyl ester binder of the VSV-43 brand, after exposure in full-scale conditions of moderate and subtropical climate for 5 years with intermediate removals after 1 and 3 years. Physical and mechanical characteristics (strength and modulus of elasticity under tension, compression and bending) and glass transition temperature are determined. Studies have shown a high preservation of properties at 20 °C: 90–100% in VKU-51 and 73–100% in VPS-58, depending on the type of test.


Recent observations indicate that CD control for the 0.18 micrometer process generation using KrF exposure (k1 equals 0.41) could be sensitive to borderline detectable defect sizes (200 to 300 nm) on a 4X reticle. It is of interest to determine if these 'sub-killer' defect sizes can become process window limiting. It is also important to determine if CD error is sensitive to the interaction between defects and scattering bar (SB) OPC features. The experiment was based on a typical 0.18 micrometer process using the Defect Sensitivity Monitor (DSM) Reticle -- designed by MaskTools and manufactured by Photronics. Printed wafer data was presented previously on isolated feature cases. Here, data is presented on dense feature cases. In agreement with earlier isolated data, greater than 10% printed CD error was found for defects occurring on the main feature such as a 200 nm bump or a 250 nm divot on a 4X reticle. Greater than 6% of the exposure latitude can be lost due to plus or minus 50 nm (4X) mask feature width deviations.


Global Observation of Forest and Land Cover Dynamics (GOFC-GOLD) is a coordinated international effort to ensure a continuous program of space-based and in situ forest and other land cover observations to better understand global change, to support international assessments and environmental treaties and to contribute to natural resources management. GOFC-GOLD encourages countries to increase their ability to measure and track forest and land cover dynamics by promoting and supporting participation on implementation teams and in regional networks. Through these forums, data users and providers share information to improve understanding of user requirements and product quality. GOFC-GOLD is a Panel of the Global Terrestrial Observing Sy stem (GTOS), sponsored by FAO, UNESCO, WMO, ICSU and UNEP. The GOFC-GOLD Secretariat is hosted by Canada and supported by the Canadian Space Agency and Natural Resources Canada. Other contributing agencies include NASA, ESA, START and JRC. Further information can be obtained at


Rainfall has been identified as one of the main causes for slope failures in areas where high annual rainfall is experienced. The slope angle is important for its stability during rainfall. This paper aimed to determine the impact of the angle of soil slope on the migration of wetting front in rainfall. The results proved that under the same rainfall condition, more runoff was generated with the increase of slope angle, which resulted in more serious erosion of the soil and the ascent of wetting front. A modified Green-Ampt (GA) model of wetting front was also proposed considering the seepage in the saturated zone and the slope angle. These findings will provide insights into the rainfall-induced failure of soil slopes in terms of angle.


From the perspective of methods of phenomenology,natural beauty is both different from the or-dinary objects of intentionality su ch as objects of entity and objects of conception,and different from pure objects of intentionality such as artistic beauty,Natural beauty is a structure of intentionality,in which the aesthetic interest,concepts of entertainment,and such modes of aesthetic perception as metaphor and affective images all blend into one.


Abstract This article explores the ethical consequences of the seemingly benign suggestion that the retelling of an event of state sponsored violence through the protocols of the law can provide a lesson/forum for fostering "discursive solidarity." Focusing on the example of post‐dictatorship Argentina, the apparent pedagogical soundness of transmitting the traumatic event through legal commemoration will be complicated by considering how the law is employed as a mechanism for bracketing divisive memories and affects that interrupt the coherence of the national imaginary. Underlining these issues will be a concern with the difficulty of historicizing abject affections, of interpreting and transmitting post‐traumatic rage through the intertextual web of normative allusions. The discussion grapples not only with the political/practical consequences of attempting to absorb and transmit (hermeneutically) the disavowed affects of a social traumatic event, but also speculatively gestures us to consider another sense of justice: one that provides the impetus to confront how we are obligated before that which is lost through our terms.1


Oxidation of 2-aminopyrimidine (2Apy) by hydroxyl radicals (˙OH) in aqueous medium has been studied using pulse radiolysis coupled to optical absorption and M05-2X/6-311++G(d,p) level DFT calculations aimed at elucidation of the reaction mechanism. The rate constant (k) 2.76 ± 0.06 × 109 M−1 s−1 determined by the pulse radiolysis method for the title reaction at neutral pH reflects a diffusion-controlled process. The maximum absorption wavelength (λmax 330 and 550 nm) of transient(s) remains intact in the pH range 10.5–7. Radical adduct formation (RAF) reactions with N1 (N3 is an identical site), C2, C4 (C6 is an identical site) and C5 as the target atoms, hydrogen transfer (HT) reaction with amino group and single electron transfer (SET) of 2Apy with ˙OH were modelled theoretically. Lowest Gibbs free energy of activation (ΔG≠) in solution, 1.72 kcal mol−1, was calculated for RAF at C5; the computed k value for this process is 2.0 × 109 M−1 s−1 using the transition state theory (TST). The relative yield (87%) of this major product predicted from the computed k value shows excellent agreement with the results of the pulse radiolysis redox titrations. Subsequently, the possibilities for other RAF reactions, HT and SET were ruled out. As an extension to the above work, we have carried out a theoretical survey of the reactivity of ˙OH with 4-aminopyrimidine (4Apy); wherein the RAF at C5 is proposed as the most probable mechanism with a ΔG≠ of 2.15 kcal mol−1.


Formulates the problem of incipient fault detection and diagnosis for rotating machinery in a statistical model-based framework. This includes problem description, modeling of rotating machinery and fault mechanisms, formulation of the detection and diagnosis problem, and analysis of performance of the proposed technique.


This paper revisits the problem of preference intensity modelling by proposing and analysing the novel concept of *preference intensity functions*. These retain what are argued to be the most essential properties expected from the consistent numerical representation of preference intensity orderings and the ordinary preferences induced by them. Their existence is characterized by simple and clearly interpretable axioms, while they are also shown to be genuinely ordinally unique and more general than utility functions associated with utility-difference representations. The empirical content of this model is pinned down by means of weak necessary and sufficient condition on observable behavioural data that include choices and additional observables with intensity-revealing potential such as response times, willingness to pay or survey ratings. Finally, a particular normalization of the model allows for simple ordinal interpersonal comparisons of preference intensities to be made, which in turn invite a novel notion of *intensity efficiency* that is shown to be well-defined and to refine Pareto efficiency by discarding allocations that are dominated on intensity-difference grounds.


Gender issues involved in the process of rural succession in Brazil are present in the research agenda related to concern for the future of rural areas. Taking these aspects into consideration, the objective was to identify whether young rural women from Rio Grande do Sul (RS) project their future in the countryside, intend to be successors of their family's rural property, or envision a future in the urban environment. Allied to this, we sought to identify factors that influence family succession and the permanence of these young people in the field, as well as possible gender distinctions involved in this process. For the survey of quantitative data we used a closed questionnaire, applied in the second half of 2018 to 743 young rural men and women who attended high school in RS. Although 47.9% of young people are interested in staying in rural areas, young women, when compared to young men, are less encouraged by their parents to stay on the property, have less interest in all aspects that address rural issues, such as being a successor (28.6%), being a manager (31.5%), and stay on property (33.5%). Issues related to non-recognition of female work and the difficulties encountered in working in the countryside, as well as possibilities for professionalization and gain of autonomy in the urban environment, drive the interest of young women in leaving the countryside.


This study investigates the long-term equilibrium relationship between international tourism and energy consumption as proxied by oil and gas consumption and the direction of causality among themselves in a small island, the Turkish Republic of Northern Cyprus TRNC . Results reveal that energy consumption is in long-term relationship with international tourism development; international tourism has inelastic and positively significant impact on the growth of energy in the long-term period. Furthermore, energy consumption significantly converges to its long-term equilibrium level by 74.9 percent speed of adjustment every year as contributed by international tourism in Northern Cyprus. Finally, the results of the present study reveal that there is unidirectional causality that runs from international tourism development to the growth of energy consumption in the island. Thus, this major finding suggests that international tourism in Northern Cyprus is catalyst for energy growth in the long-term period


Cutaneous infantile haemangioma (IH) occurs in 5-10% of neonates, with multiple IH (>1) in 30% of those1 . Expert opinion currently recommends routine liver ultrasound(USS) for five or more(5+ ) IH2,3 , and if hepatic haemangiomas(HH) are identified, to test thyroid function3 even if neonatal thyroid screening occurred. Supportive data from one cohort demonstrate associations between 5+ IH and HH1 , and between HH and adverse clinical outcomes (cardiac failure/hypothyroidism)4-6 .


Environmental deterioration is a challenge for all major cities. Public authorities improve environment monitoring systems, develop and implement measures to reduce the negative consequences of manufacturing activities, inform the population. The article analyzes data on the state and dynamics of the environment status in Kemerovo (Western Siberia, Russia), where a large number of manufacturing enterprises are concentrated. The results of Kemerovo population survey aimed at assessment of perception of the air and water pollution degree, the attitude to the influence of meteorological conditions and landscape features on the environment status, and identification of respondents' opinions about the enterprises having the greatest impact on the environment are described. In addition, the survey assessed changes in the environment status and the degree of personal concern of citizens. The results of the survey were compared with statistic data; a number of discrepancies were identified. The authors offer some recommendations for public authorities on working with the population on environmental issues.


relationships with cultural elements of death — graveyards, crypts, churches, etc. — I plan to explore the cultural significance of these landscapes as they pertain to the concepts of transgression and resurrection in Shakespeare's Romeo and Juliet. Specifically, I argue that when Shakespeare's characters attempt to recreate the miracle of resurrection upon those spaces scripted solely for the dead, they are punished not only for their inability to recognize the culturally acceptable meanings of the deathscapes but they also mirror Satan's deadly sin of Pride5 by taking upon themselves the power of resurrection, a form of miracle meant for divine application only. By having his protagonists "playing God", as it were, Shakespeare adds layers of both tragedy and flaw to their characters while at the same time reinforcing the necessity of the boundaries they so foolishly transgressed. Through his use of interior and exterior spaces, physical objects, and metaphysical understandings of religion and the religious canon, Shakespeare distances the concept of resurrection from the more accepted Christian — specifically Protestant — meanings of redemption and rebirth, and redefines it through the use of what early modern Protestants would term witchcraft and black magic, forms of supernatural power associated with Catholicism against which the early modern English playgoer was vigorously indoctrinated. The characters of Friar Lawrence, Romeo, and Juliet, then, are placed in both physical and metaphysical danger as they overreach their strictly human abilities and attempt to access the powers of the divine. It is possible, Shakespeare shows us, that we can misuse deathscapes in terms of both the


In the conditions of low Signal-to-Noise Ratio ( SNR ) of seismic data and a small quality of log infor- mation , the consequences of seismic interpretation through the impedance inversion of seismic data could be more precise. Constrained sparse spike inversion ( CSSI ) has advantage in oil and gas reservoir predication be- cause it does not rely on the original model. By analyzing the specific algorithm of CSSI , the accuracy of inver- sion is controlled. Oriente Basin in South America has the low amplitude in geological structure and complex li- thologic trap. The well predication is obtained by the application of CSSI.


Since 2004, the web 2.0 has been based on the contributions and the interaction of internet users to easily produce and publish the content. This type of philosophy which has been approved by the web community encourages users to participate and exchange, has resulted in a huge mass of diverse information. However, this philosophy based on the collaboration of users brings many problems such as the information overload, the lack of information quality's control, the search results accuracy and possibilities of sorting and classifying by the level of relevancy. This paper is a part of a work research conducted in our laboratory that focuses on the quality of information on the collaborative web and its related issues. We propose a content management framework that will handle the content during its lifetime on the web. Our approach reuses the static validation mechanism of content and adds the concept of dynamic validation mechanism performed by internet user's community. In this context, we will model a validated blog's system management based on our approach using UML standard.


We discuss a new numerical method for the determination of excited states of a quantum system using a generalization of the Feynman-Kac formula. The method relies on introducing an ensemble of non-interacting identical systems with a fermionic statistics imposed on the systems as a whole, and on determining the ground state of this fermionic ensemble by taking the long-time limit of the Euclidean kernel. Due to the exclusion principle, the ground state of an n-system ensemble is realized by the set of individual systems occupying successively the n lowest states, all of which can therefore be sampled in this way. To demonstrate how the method works, we consider a one-dimensional oscillator and a chain of harmonically coupled particles.


Major depressive disorder (MDD) is estimated to affect one in twenty people worldwide. MDD is highly comorbid with cardiovascular disease (CVD), itself one of the single largest causes of mortality worldwide. A number of pathological changes observed in MDD are believed to contribute to the development of cardiovascular disease, although no single mechanism has been identified. There are also no biological markers capable of predicting the future risk of developing heart disease in depressed individuals. Plasminogen activator inhibitor‐1 (PAI‐1) is a prothrombotic plasma protein secreted by endothelial tissue and has long been implicated in CVD. An expanding body of literature has recently implicated it in the pathogenesis of major depressive disorder as well. In this study, we review candidate pathways implicating MDD in CVD and consider how PAI‐1 might act as a mediator by which MDD induces CVD development: chiefly through sleep disruption, adiposity, brain‐derived neurotrophic factor (BDNF) metabolism, systemic inflammation and hypothalamic–pituitary–adrenal (HPA)‐axis dysregulation. As both MDD and CVD are more prevalent in women than in men, and incidence of either condition is dramatically increased during reproductive milestones, we also explore hormonal and sex‐specific associations between MDD, PAI‐1 and CVD. Of special interest is the role PAI‐1 plays in perinatal depression and in cardiovascular complications of pregnancy. Finally, we propose a theoretical model whereby PAI‐1 might serve as a useful biomarker for CVD risk in those with depression, and as a potential target for future treatments.


We study the small scale structure of axion dark matter in the post-inflationary scenario, which predicts the formation of low-mass, high density clumps of gravitationally bound axions called axion miniclusters. To this end we follow numerically the cosmological evolution of the axion field and the network of strings and domain walls until the density contrast is frozen. Our simulations, comprising up to 81923 points, are the largest studies of the axion field evolution in the non-linear regime presented so far. Axitons, pseudo-breathers of the Klein-Gordon equation, are observed to form in our simulation at late times. Studying their properties analytically and numerically, we observe that in particular the earliest axitons contribute to density perturbations at the typical length scale of miniclusters. We analyse the small scale structure of the density field, giving the correlation length, power spectrum and the distribution of high density regions that will collapse into axion miniclusters. The final density field of our simulations can be used to calculate the minicluster mass fraction in simulations including gravity. In particular, we find that typical minicluster progenitors are smaller than previously thought and only of moderate, 𝒪(1) overdensity. We expect these miniclusters to have a rich sub-structure, emerging from small-scale fluctuations produced in the collapse of the string-wall network and from axitons.


Being a prince in name but a prisoner in reality, the second half of Cao Zhi' life is very deplorable. There are two reasons for his misery. The main reason is that he fought for the crown against Cao Pi but failed. The other is that he offended Wu Zhi, Cao Pi's confidant. The ridicule, satire and contempt that Cao Zhi directed towards Wu Zhi in his "Letter to Wu Jizhong" hurt Wu Zhi's feelings so much that the latter was determined to revenge himself on Cao Zhi by helping Cao Pi. The letter has long been taken as the evidence of the friendship between Cao Zhi and Wu Zhi and their real relations have not been identified. Consequently, people failed to recognize the second important reason for Cao Zhi's misery in the second half of his life.


Quantum Simulation
Ultracold atomic gases are very good at simulating electrons in solids but lack one essential party trick: charge. Their neutrality makes it challenging to simulate phenomena such as the quantum Hall effect, which, in the case of charged electrons, is easily induced by an external magnetic field. One way to produce a similar effect in a neutral system is to rotate it, but achieving the equivalent of strong magnetic fields remains difficult. Fletcher et al. rotated a gas of trapped sodium atoms, reaching a state in which the gas could be described by a single lowest Landau-level wave-function. The system is expected to be a testbed for studying the behavior of strongly interacting many-body states.

Science , aba7202, this issue p. [1318][1]

 [1]: /lookup/doi/10.1126/science.aba7202


The article analyzes and introduces Yining City's atomospheric environment pollution characters,carries on analyzing mornitored data of atomospheric pollutant of Yining City from 2001 to 2004,has an insight into Yining City's atomospheric polluted status,main pollution type is type of smoke from burning coal and pollutant are TSP,NO_2 and SO_2.It has put forward improving measure and suggestion for atmospheric pollution and has down a valuble exploration and research for knowing well and control Yining City's atmospheric environment quality.


The present study aimed to uncover the pharmacological function and underlying mechanism of puerarin as a potential treatment for COVID‐19, using an in silico methodology, including network pharmacology and molecular docking. The pivotal targets of puerarin to treat COVID‐19 were identified and included the epidermal growth factor receptor (EGFR), tumour necrosis factor (TNF), tumour protein p53 (TP53), caspase 3 (CASP3), RELA proto‐oncogene (RELA), Fos proto‐oncogene (FOS), caspase 8 (CASP8), prostaglandin‐endoperoxide synthase 2 (PTGS2), interleukin 2 (IL2), protein kinase CB (PRKCB), B cell lymphoma/leukaemia gene‐2 (BCL2), protein kinase CA (PRKCA), nitric oxide synthase 3 (NOS3) and peroxisome proliferator–activated receptor gamma (PPARG). Functionally, the anti–COVID‐19 action of puerarin was associated with the suppression of oxidative stress and inflammatory cascades, and cell apoptosis. The signalling pathways of puerarin to treat COVID‐19 included modulation of the pathways of apoptosis, IL‐17 signalling, mitogen‐activated protein kinase (MAPK) signalling and TNF signalling. Molecular docking data illustrated the binding capacity of puerarin with COVID‐19 and the effective anti–COVID‐19 activity of puerarin. Taken together, our current network pharmacology–based findings revealed the pharmacological role of puerarin in the treatment of COVID‐19. Furthermore, the bioinformatic findings elucidated that some of these pivotal targets might serve as potential molecular markers for detecting COVID‐19.


We have seen that this map is well-defined and injective; we still have to show that it is surjective. In concrete terms, given a Weil q-integer π, we need to construct a simple abelian variety over Fq on which the Frobenius element acts as π. The only known construction is by reducing a CM abelian variety from characteristic zero. Specifically, our construction will proceed in five steps. First, fix a CM field L containing Q[π], and a CM type (L,Φ). (The field L and data Φ will be determined later.) Construct an abelian variety A0 over C of this CM type. In particular, A0 has an action by the element π ∈ L, and this automorphism has the desired characteristic polynomial. Second, show that A0 is in fact defined over a number field K. Third, show that A0 has good reduction at a place v of K over p. Thus the identity component of the special fiber is an abelian variety A, defined over some field of characteristic p, whose endomorphism ring contains L. Fourth, determine the Frobenius action on A. More precisely, we will see that the Frobenius element of A comes from an element πA of L, and determine its valuation at every place of L. By a judicious choice of (L,Φ) we can arrange that πA is "almost" π, in a sense which will be made precise. Fifth, argue that π itself must be in the image of the map HTq.


The following comments and questions describe why I consider the Final Reports NCSTAR 1A, 1-9 and 1-9A to be incomplete, inconsistent and erroneous. Sincere thanks are due to Chris Sarns, Gregg Roberts, David Chandler and Dwain Deets for their helpful comments. I hope many others will spend the time to evaluate the NCSTAR reports carefully, follow the references herein, and draw their own conclusion. Public disclosure of one's convictions is always a risk, but silent acceptance is not an option. Permission is granted to reprint or quote excerpts freely and solely without charge.


Abstract Cotton fabric on both surfaces was coated with polymerization of fluoromonomer followed by adsorption of fluorosurfactant by a new technique admicellar polymerization to obtain durable hydrophobicity. Water repellence properties were determined in terms of simple drop test contact angles. The coating on cotton fabric exhibited the right water contact angle of 137.23° and left contact angle 138.35° (an average value of 137.79°). However, the durability of the coatings was decreased after simple home laundering with a decrease in water contact angle value. The surface morphology was evaluated by scanning electron microscopy before and after polymerization. Beside this chemical composition on the cotton, the surface was evaluated by EDS analysis to determine the number of fluorine moieties deposited on the cotton surface by this technique.


Glyceraldehyde-3-phosphate dehydrogenase was completely inhibited by incubation with an excess of ρ-nitrophenylcarbamoylmethyl bromide (NPCM-Br).The amount of NPCM residue bound to the enzyme was determined by spectrophotometric measurement at 380 mμ of the p-nitroaniline liberated upon alkali hydrolysis. The completely inhibited enzyme contained 1 NPCM residue per 50,000 grams of protein. The NAD-free apoenzyme had no activity in the phenazine methosulphate-2, 6-dichlorophenolindophenol assay system. Upon addition of NAD to the above system, the activity of the holoenzyme was restored.


Frantic state is commonly seen in the ceremonial on-the-spot investigation of anthropology and ethnology.This is unique in some folk custom ceremony.Viewed from the angle of discipline history of anthropology, many famous anthropologists such as J.G.Frazer,R.Firth,Clifford·Geertz and Michel·Foucault showed their concern for this phenomenon.


The purpose of this work was to investigate the phenomenon of school bullying as it occurs among middle-class students. The chapters of this work is an effort to clarify the phenomenon. References are made taking into consideration all the social, psychological and legal aspects through a simultaneous tiling of the sociological view of the phenomenon. A brief analysis of the findings of various surveys was conducted in Cyprus, Greece and Internationally. The incidence of bullying phenomena, school locations and forms of intimidation has been identified, while an attempt has been made to outline the profile of both bullies and victims. Then a presentation of the legal handling of the matter was made, based on the International Convention on the Rights of the Child, as well as the institutional framework proposed by the Council of Europe and how it has been incorporated into the institutions of Greece and Cyprus. Finally, the school's contribution to addressing the phenomenon was highlighted through the implementation of specific programs and the promotion of peaceful problem solving and mediation. Through the aforementioned, the legal, administrative and educational management of the phenomenon of school bullying in secondary education has been attempted and presented.


We have, on Alfa Laval's behalf, tried out suitable control equipment to control the Brazed Heat Exchanger in steam applications. Reports have come in from several countries telling us about problems occuring when trying to control steam. Damages have arisen (often as a crack in the first or the last plate) due to fatigue caused by pressure variations in the steampipe. We have through a market analysis together with tests in a laboratory produced an equipment that is, according to our opinion, functional as well as economically satisfactory. The equipment will hopefully solve the problems mentioned above.


Aiming at the common used of the kinds of finite element software in project design,it puts forward the solving of the strength checking calculation of pile foundation and the calculation of horizontal displacement through the finite element model.And this makes the design of pile simple,and considers the common action of pile foundation and upper structure in equivalent accuracy.


This paper proposes simultaneous Demand Side Management (DSM) and Supply Side Management (SSM) Strategies for smart Zero Energy Building (ZEB). The proposed DSM algorithm based upon game theory determines the optimal reference power of each power units during time interval of 5 min under three operational scenarios. Afterwards, the SSM strategy based on adaptive fuzzy control is proposed to control of power flow between hybrid renewable sources and PEVs of the main building for a short time interval. Moreover, an fuzzy sliding power control strategy for the controlling of battery energy storage is introduced to keep the balance between the requested power from building, PEV and output power of hybrid power generation resources. Simulation and experimental results are presented to validate the capability of the proposed power and energy flow control strategy. Keywords—Zero Energy Building, DSM (demand side management), SSM (Supply side Management), Renewable Energy, Plug-in Electric Vehicle, Control, Optimization.


Abstract This experiment aims to check the hypothesis that anxiety and stress are distinct state patterns, and to contribute to the separate measurement of anxiety as a state and as a trait. An R-and a dR-technique factor analysis of thirty-eight variables-chosen to mark, especially, anxiety, stress, and fear-was made on sixty-three "normal" students, with a month lapse. Six factors matched well across the simple structure R- and dR- resolutions: anxiety (U.I. 24), exvia-invia (U.I. 32), stress (P.U.I. 4), arousal-torpor (P.U.I. 1), overwroughtness (U.I. 23), and fatigue (P.U.I. 3); while fear response matched moderately. The main hypothesis is supported, but some provocative findings appear regarding the patterns of other states, and the distinction of anxiety as state and trait.


Aiming at the problem of improving spacecraft~′s relative state parameters measure precision,the error factors of spacecraft relative state measure technique based on monocular computer vision and target feature are analyzed.Based on the study of the influence of the quantification noise and the gray level noise on target feature image,the error model of the target feature image centroid coordinates is built.The measurement error distribution of the spacecraft's relative state is studied by using simulation test.The results show that the influence of the gray noise on the measurement precision is greater than that of the quantification noise.


The cardiac electrophysiological effects of sotalol were studied in ten patients (pts) aged 20‐65 years undergoing intracardiac stimulation studies for palpitations (7 pts) or dizzy spells (3 pts). The following measurements were made: 1. basic sinus cycle length (SCL); 2. sinus node recovery time (SNRT) following overdrive pacing; 3. intra‐atrial (PA), atrio‐His (AH) and His‐ventricular (HV) conduction intervals during regular atrial pacing; 4. effective refractory periods of the atria (AERP), AV node (AVERP) and ventricular myocardium (VERP). AV nodal functional refractoriness (AVFRP) was also determined. All measurements were repeated 10‐15 min after i.v. administration of 0.4 mg/kg of sotalol. Results were analysed by the Wilcoxon Signed Rank test. Significant increases in SCL (p < 0.01), AH (p < 0.01), SNRT (p < 0.01), AVERP (p < 0.02) and AVFRP (p < 0.01) were observed. These effects are consistent with the beta‐blocking action of sotalol. The acute increase in AERP (p < 0.01) is, however, not a common property of other betablockers and may be related to the 'class III' cellular effect of sotalol. These results are discussed in relationship to the electrophysiological effects of other beta‐blocking drugs.


Computer simulations with special versions of the one dimensional BALDUR predictive transport code are carried out to investigate the particle confinement of helium and hydrogen, the energy confinement and the burn control in the high density scenario of the ITER (CDA) physics phase. The code uses empirical transport coefficients for ELMy H mode plasmas, an improved model of the scrape-off layer (SOL), an impurity radiation model for helium and iron, and fast burn control by neutral beam injection feedback. A self-sustained thermonuclear burn is achieved for hundreds of seconds. The necessary radiation corrected energy confinement time τE is found to be 4.2 s, which is attainable according to the ITER H mode scaling. In the ignited ITER, a significant dilution of the DT fuel by helium takes place. Steady state helium fractions of up to 8% are obtained, which are found to be compatible with self-sustained burn. The SOL model yields self-consistent electron densities and temperatures at the separatrix (ne = 5.8 × 1019 m-3, Te = 80 eV)


Central venous catheter (CVC) vascular access is common among patients on hemodialysis. CVC use carries a substantial risk of central line-associated bloodstream infections (CLABSIs), costly events that place patients at a high risk of mortality. Our hospital and dialysis organization developed a cooperative strategy to reduce the rate of CLABSI among hospitalized patients on hemodialysis with a CVC. The program included the use of training and reporting tools to guide hospital staff with CLABSI prevention, as well as leadership committees to oversee the process. Fourteen CLABSIs were reported in the 17-month period prior to the implementation of the program, while no new CLABSIs occurred in the 30 months following implementation of the program. This prevention program effectively reduced the frequency of CLABSIs. Broader implementation of such programs may result in better outcomes and lower costs for hospitalized patients on hemodialysis.


This document introduces a systematic literature review on attention and vigilance detection using Electroencephalography (EEG). The purpose of this study is to investigate the state of the art in the field, find gaps, suggest future work and find answers to the research questions of the study. The review consists of an introduction that describes prerequisites for writing current study and general terms, research methods with a description of research methodology, results section which answers research questions, discussion, and conclusion sections.


Studies on manufacturing task support that can present appropriate task instructions to the workers according to the situation using augmented reality are being advanced. Thereby, even a worker who is not an expert can perform various manufacturing tasks. In this technique, a task instructions are superimposed on the captured image of the work object. Then, by presenting the synthesized image to the worker through the visual display, the task instructions are performed. Recently, the application of this technology to various manufacturing tasks has been studied. In the conventional task instruction presentation research, the presentation information was mainly static information such as mounting position of the parts, place of the operation switch and presentation of operation procedure. However, in some manufacturing tasks, it is important to operate a work tool along a three-dimensional trajectory such as assembly task, soldering, welding task, pouring task and so on. In such tasks, it is necessary to present the three-dimensional position, orientation and trajectory of the work tool to the operator. In contrast to the static information mentioned above, these can be said to be the manufacturing task support technology to present dynamic information. In this paper, an instruction of presenting three-dimensional motion for task support is examined. Then, in order to confirm its effectiveness, the results of the evaluation experiments using the operators are reported.


Nucleophilic addition reactions of benzylamines (BA) to β-nitrostilbenes (NSB) and β-cyano-4′-nitrostilbenes (CNS) have been studied in acetonitrile at 25.0 and 30.0 °C, respectively. The rate is first order with respect to BA and substrate. The rate of reaction with CNS is much lower than that expected from the rate sequence observed in aqueous solution indicating that the mechanisms of BA addition in acetonitrile and in water are different. The major factor determining reactivity of the amine addition in acetonitrile is the direct resonance effect (σ− or R−) while that in aqueous solution is the polar electron-withdrawing effect (σ) of the activating groups. Due to steric inhibition the β-phenyl rings in NSB and CNS are prevented from π-overlap with the anionic center in the TS so that the reduced resonance effect leads to unduly low addition rates. The kinetic isotope effects
and activation parameters are in line with the one step addition mechanism in which N–Cα and H–Cβ bonds are formed concurrently with a hydrogen bonded four-center cyclic transition state. The cross-interaction constant ρXY is negative and the magnitude is somewhat larger than those for other similar addition reactions.


Adoptive transfer of T cells engineered to express chimeric antigen receptors (CARs) has achieved impressive outcomes in the treatment of refractory/relapsed B-ALL, providing potentially curative treatment options for these patients. The use of CAR T in AML, however, is still in its infancy with limitations due to the innate heterogeneity associated with AML and the lack of AML-specific targets for therapeutic development. The CRLF2 gene encodes for thymic stromal lymphopoietin receptor (TSLPR) and has previously been shown to be highly upregulated in a subset of children and adults with B-ALL. Targeting TSLPR with CAR T cells demonstrates potent anti-leukemia activity against TSLPR-positive B-ALL (PMID 26041741). Through Target Pediatric AML (TpAML), we profiled the transcriptome of nearly 3000 children and young adults with AML and identified CRLF2 (TSLPR) to be highly expressed in a subset of AML, including the majority of AML harboring KM2TA (aka MLL) fusions. TSLPR cell surface expression was validated in primary patient samples using flow cytometry, which showed uniform expression of TSLPR on AML blasts. Given that TSLPR is expressed in AML with confirmed cell surface expression, we developed TSLPR-directed CAR T for preclinical evaluation in AML.
 We generated a TSLPR-directed CAR using the single-chain variable fragment (scFv) derived from an anti-TSLPR binder (clone 3G1, MD Anderson), IgG4 spacer and 41-BB/CD3zeta signaling domains. The in vitro cytotoxicity of TSLPR CAR T cells was evaluated against the REH-1 cell line and primary AML specimens. TSLPR CAR T cells demonstrated anti-leukemia activity against REH-1 as well as against primary AML specimens. To evaluate the in vivo efficacy of TSLPR CAR T cells, we developed a patient-derived xenograft (PDX) model using bone marrow cells from a TSLPR-positive patient. These cells provided a robust model system to evaluate the in vivo activity of TSLPR CAR T cells, as they produced an aggressive leukemia in humanized NSG-SGM3 mice. The PDX generated from these cells died within 2 months of transplant with significant leukemia infiltration into the bone marrow, liver, and spleen. In the in vivo study, the leukemia burden was assessed by flow cytometric analysis of AML cells in the peripheral blood and bone marrow aspirates following treatment with unmodified control or TSLPR CAR T cells given at 10x10 6 T cells per mouse. After CAR T treatment, we detected a significant decrease in leukemia infiltration into the peripheral blood and bone marrow in the CAR T-treated mice compared to mice that received unmodified T cells.
 In this study, we report that similar to B-ALL, CRLF2 (TSLPR) is overexpressed in a subset of AML, providing a strategy to eliminate AML cells with CAR T cell therapy. We validated the cell surface expression of TSLPR and showed that the expression is uniform across AML specimens. We further demonstrate that CAR T cells targeting TSLPR were effective in eliminating AML cells in vitro and in vivo. Given that TSLPR is highly expressed in the KMT2A-rearranged AML, a subtype that is associated with poor outcomes, TSLPR-directed CAR T cells represent a promising immunotherapy for this high-risk AML subset.

 Pardo: Hematologics, Inc.: Current Employment.


Cook looms as large in Australian statuary as he does in nomenclature and, perhaps especially, psyche. To those who still deify him as the explorer at the vanguard of white-hatted colonial Enlightenment he remains the Neil Armstrong of his day – he who sailed where dragons be to bring English light and civility to the oldest continuous civilisation on the planet. To others of this continent, he is a sinister bogey man and a monster, the doorman who ushered in later colonisation with all its extreme violence, dispossession and ills with his east coast arrival in 1770 – in which his first act was to personally shoot two Gweagal men at Kamai.


FOR THESIS University of Oulu Faculty of Technology Degree Programme (Bachelor's Thesis, Master's Thesis) Major Subject (Licentiate Thesis) Degree programme in Environmental Engineering Author Thesis Supervisor Hakso, Heidi Caló A., Research Doctor


Nowadays,with the rapid process of urbanization,development and utilization of urban underground space has become the important tool of expanding building space capacity,relieving the jamming situation and enhancing the environment quality. To deepen the recognition of Tai'an urban underground space and fully utilize the potential reserve space resource,through collecting drilling logging,geological maps and topographical maps,with the help of mapGIS 3D modeling software,3D geological model of Tai'an city has been set up. Geological information,such as rock and soil in engineering projects can be expressed in an intuitive way. It will provide reliable geologic bases for the development of urban underground space in Tai'an city.


The fact that roughly 3.4 million children – or 27% of the child population – are living in poverty is a critical policy issue. Much has been made of the government's commitment to reducing child poverty, particularly its first target of a 25% fall in the numbers in poverty between 1998/99 and 2004/05, which has just been narrowly missed. This concern about child poverty relates not just to the immediate effects of poverty. More importantly, the experience of poverty in childhood may influence social, economic and health outcomes throughout later life, leading to the 'persistence' of poverty into adulthood and consequences for the next generation. In order to investigate the long-term impact of growing up in poverty, we need to observe children's family circumstances and then return to see how they are doing later in life. Such information can be found in the two British cohort studies: the National Child Development Study and the British Cohort Study. The availability of these two data sources – one a cohort born in 1958, the other a cohort born in 1970 – allows us to compare the fortunes of people who were teenagers in the 1970s and the 1980s. Our initial estimates of the persistence of poverty compare the poverty rates of people in their early thirties between those who grew up in poverty and those who did not: ■ Of people whose families were poor when they were 16 in the 1970s, 19% were poor in their early thirties and 81% were not. So the 'odds' against growing up to be poor if your parents were poor were over four-to-one. ■ Of people whose families were not poor when they were 16 in the 1970s, 90% were not poor in their early thirties while 10% were poor. So the 'odds' against growing up to be poor if your parents were not poor were about nine-to-one. Persistence of poverty can be measured by dividing the odds of being poor if one's parents were poor by the odds of being poor if they were not – a number called the 'odds ratio'. Calculations of this odds ratio show that for a teenager in the 1970s, the odds of being poor as an adult were doubled if his or her parents were poor. Similar calculations for the later cohort who were teenagers in the 1980s show that the odds of being poor in adulthood were …


"In the administration of the country it is impossible to ignare the ideas or beliefs of the people or the religious personages, anymore than we can disregard the opinions of their chiefs and leading men. These religious gentry, whether virtous or otherwise, possess great influence, and in dealing with the people i t is necessary to use ali men of influence as far as possible to aid in the administration"l


The main projects to digitization and their purpose, a journey through physical libraries and digital libraries discovering the Google project.


Rockburst process of the surrounding rock of a circular tunnel is modeled by use of FLAC.Effects of the horizontal stress that is less than the vertical stress and the post-peak brittleness of rock are studied.The rock elements exhibit linear strain-softening behavior after the occurrence of failure and ideal plastic behavior and the failure meets the composite Mohr-Coulomb criterion with tension cut-off.The tangential stress of a row of elements in the surrounding rock is monitored.The tangential stress rock-burst criterion proposed by Xu and Wang is used to determine the state of elements.Numerical results show that the angle between the line(linking the V-shaped notch tip and the central point of the tunnel) and the horizontal axis of the tunnel increases to 45°from that less than 45°as the horizontal stress is increased. As the horizontal stress increases,the number of the failed elements and the elements occurring rockburst increases and the peak tangential stress is increased.At higher post-peak brittleness of rock,the shear bands become apparent,and it is easy to form the V-shaped notches.The number of the failed elements and the elements occurring rockburst increases.The distance between the rock with peak tangential stress and the tunnel surface is increased.


In this paper we discuss a Case-Based Reasoning (CBR) method which is an on-line learning mechanism for dynamic selection and modification of behavior assemblages for collision avoidance of multi-robot system. The CBR module is designed as an additional reactive control system which provide flexible performance in novel environments without extensive high-level reasoning that would slow the system down. The results by robot simulation software MissionLab show that the CBR are effective for making decisions to avoid the collision with static obstacles as well as moving robots in multi-robot system.


Geometrically dependent saturation of the THz radiation power and spectral shift are observed. Additionally, significant enhancement of THz-radiation power is observed at the Brewster-incident-angle case.


The application of ultrasound standing wave fields (USWFs) to cell suspensions results in the radiation force‐mediated movement of cells to areas of the field separated by half‐wavelength intervals. In this study, USWF‐induced cellular arrangements were maintained after removal of the sound field by polymerization of a collagen type‐I solution around the organized cell bands. Using a water tank setup, cell suspensions of varying concentrations were exposed to a 1‐MHz, continuous wave USWF for 15 min, during which time collagen polymerization occurred. An acoustic pressure amplitude of 0.2 MPa was used to achieve the USWF‐induced cell organization. Compared to sham samples with a random cell distribution, cell viability was not adversely affected by USWF exposure. The organization of cells into a banded pattern within the collagen gels resulted in a significant two‐fold increase in cell‐mediated gel contraction, suggesting that USWF‐induced cell organization leads to differential extracellular matrix remod...


Human Resources (HR) is the main component of an organization that becomes a planning and active actor in every activity of the organization. This has triggered the company to improve the performance of its employees. This research aims to identify the influence of working environment and working motivation for employee performance on human resources Indonesia Stock Exchange. The sampling technique using Slovin found 150 respondents with the type of simple random sampling. Data analysed using multiple linier regression analysis. The results are working environment and working motivation has partially and also simultaneous effect significant positive on employee performance.