The complete equations for the electromagnetic field of an infinitesimal current element are given. The integration of these equations is considered for the case of a finite radiator having an empirical current distribution. Tables are included to facilitate computation and consideration is given to difference in phase of the current in various portions of the radiator.


To evaluate the accuracy of the smartwatch in estimating carotid-femoral pulse wave velocity (cfPWV). A cohort of gender-matched volunteers aged 18–80 years were recruited. At the sitting and supine positions, cfPWV was measured alternately by smartwatch and CompliorAnalyse, for each participant, and nine sets of data were collected from each participant with a 60 s interval between measurements. The accuracy of cfPWV measurement for smartwatches was assessed using mean error (ME) and mean absolute error (MAE), while the consistency of the two methods was assessed using the Bland-Altman analysis and concordance class correlation. A total of 347 participants were enrolled. The mean cfPWV was 9.01 ± 2.29 m/s measured by CompliorAnalyse and 9.06 ± 1.94 m/s by smartwatch. The consistency correlation coefficient (CCC) was 0.9045 (95% CI 0.8853–0.9206), the ME was 0.046 ± 0.92, and the MAE was 0.66 (95% CI 0.59–0.73). Bland-Altman analysis showed that the error of 95% samples was in the range between −1.77 m/s and 1.86 m/s. The Kappa value of cfPWV greater than 10 m/s was 0.79, the area under the ROC curve was 0.97 (P < 0.001), sensitivity was 0.90, specificity was 0.93, positive predictive value was 0.83 and negative predictive value was 0.96. Smartwatch can accurately estimate cfPWV to evaluate arterial stiffness. This method is simple and feasible and is suitable for people to actively and early monitor vascular elasticity.


The objective of this research was to create a case-based / problem-based teaching and learning curriculum that enables students to explore design and manufacturing engineering, management, biomedical engineering, computer systems and other subjects with the aid of a generic architecture, that includes 3D web-browser readable multimedia, text, images, interactive videos, active codes for calculations, and even self-assessment tools (as spreadsheets and spreadsheet templates). In this paper we introduce the principles of our educational methods and solution, and explain and demonstrate (during our presentation) a series of case-based learning modules that encourage reusable interactive multimedia development, team-oriented learning and problem-solving with real-world challenges, focusing on manufacturing engineering and technology education. Our efforts are supported by over 30 academic and industrial partners, assuring the diversity, the relevance and the quality of this rapidly growing library and teaching / learning method.


The enantiomer ratio (ER) is currently the standard descriptor of enantiomeric (chiral) signatures for environmental samples. In this paper, we argue for the adoption of the enantiomer fraction (EF) as the standard descriptor by showing drawbacks to the use of ER. The enantiomer fraction is superior because it provides a more meaningful representation of graphical data and is more easily employed in mathematical fate expressions. Several useful expressions are presented that allow EF to be used for tracking and apportioning chemical movement between environmental compartments and for investigating microbial degradation processes.


OBJECTIVE Recombinant IGF‐I is now available for the treatment of GH insensitivity (Laron syndrome). We have determined the effects of IGF‐I on soft connective tissue and bone metabolism in a group of patients with this disorder.


Two cases of cutaneous sarcoidosis are described. Both patients were middle aged males in whom cutaneous sympioms began abruptly and consisted of myriads of small papules on the trunk and limbs. Neither case had any radiological changes in the lung fields.


The invention relates to a diagnostic method for the failure of a switch current circuit. The diagnostic method comprises the following steps of: collecting an electric signal of the switch current circuit, so that the collected electric signal is used as an output current signal of the switch current circuit; performing wavelet transformation on the collected electric signal; calculating an energy feature value of a wavelet of the electric signal; performing feature extraction of principal component analysis (PCA) on the energy feature value of the wavelet and reducing the number of dimensions to obtain the optimal feature vector; and conveying the optimal feature vector to genetic algorithm_back propagation (GA_BP), and outputting a failure diagnostic result by a GA_BP neural network classifier. When the diagnostic method is used, the stability of a structure of the neural network classifier can be enhanced, the problem that a local minimum value occurs in a neural network is solved, the training time is reduced, and the testing speed is increased.


With the booming of homestay around Malaysia, it has become a profitable sector under tourism. However, tourist have a difficulty to find and booking homestay as there are not many homestays that have an online booking. Hence, the main objective of this project is to develop a mobile application to become a hub for all homestay in Malaysia. The application will provide a searching homestay function, booking homestay and help navigate function for tourist to the particular homestay selected. This application will help users to save time and cost of travel to get information of homestay that they want to book. The research will cover some of the homestay around Umbai, Melaka and more areas will be cover later. Android operating system has been chosen as the platform for this application because Android's users are potentially big in numbers. With reference to Technology Acceptance Model and using Rapid Application Development (RAD) as primary method, this study provides a more solid reason to come up with a mobile application using Android. An Android mobile application has become the outcome for this project.


The invention relates to the field of non-ferrous metallurgy and specifically to a method for processing laterite (oxidized nickel) ores with the direct production of ferronickel in the form of metal granules. The method comprises mixing the ore with a solid reducing agent and with fluxing additives, briquetting the resultant mixture, a reduction firing of the briquetted charge in tubular rotary furnaces forming ferronickel lumps and separating ferronickel from ground clinker. The fluxing additives are input into the mixture in the amounts of 6-12% CaCO3, 6-12% Al2O3, 0-10% SiO2 of the mass of the ore, the maximum temperature in the lump formation zone is maintained in the range of 1300-1350oC, and the content of carbon residue in the clinker slag is maintained in the range of 0.05-0.55%, and preferably within the range of 0.1-0.4%. A mixture of bituminous coal and anthracite or coke is used as the solid reducing agent. The method allows for achieving high performance when firing in order to increase the effectiveness of directly producing ferronickel from high-magnesium silicate nickel ores.


In Boston at what is now the Perkins School for the Blind, Samuel Gridley Howe produced two atlases during the 1830s with raised lines and alphabetic characters for blind students that were also legible for sighted readers. Believing that blind students needed to learn both the form and content of textbooks for the sighted, Howe chose materials and methods of production to mitigate difficulties that these design principles presented for blind users. Howe's commitment to visual forms of communication manifests a tension in nineteenth-century approaches to educating the blind between a belief in universal capabilities and one in sense-specific knowledge.


Femtosecond laser etching is applied to fabricate cylindrical, quadrangular and circular hole micro-structures to explore the variation patterns of their reflectivity. The results show that the cylindrical and quadrangular texturing structures have the optimal anti-reflection effect (the reflectivity is always below 6%) in the wavelength range of 350-1000 nm, which is of reference value for the study of fabricating low-reflectivity texturing on monocrystalline silicon surfaces.


The 80 K liquid nitrogen distribution system is one of the essential sub-systems of SST-1 cryogenics system. It consists of 80 K Thermal shields, current feeders system, integrated flow distribution and control system, pre-cooling heat exchanges and purifier of helium plant system. The maximum operating pressure of liquid nitrogen is 1.9 bar (a) from the source storage tanks. Preliminary, authors observed the frosting in one of the section of return LN 2 cryo line near the phase separator interface. Due to this problem, they were unable to collect the phase separated LN 2 in the sub-cooler back. Appropriate investigation of leaks, reason for the leaks identified. Welding protocols (ASME section IX) and replacement of Bellows (as per EJMA standards) were carried out under satisfying the flexibility criteria. The evacuation of transfer lines, insulation wrapping, welding and assembly in congested space and safety aspect at 12 m height were the challenges experienced during repairing task. Due to this activity, the huge amount of LN 2 fluid has been saved. In this paper, authors will mainly focus on the identification of weld leaks, welding and repairing process, vacuum evacuation process, design of sealing set up, NDT testing of weld joints and helium leak testing at operating condition of cryogenic transfer lines after welding task.


In this study, the effect of average daily concentrate consumption on calf weaning time and performance was studied for better calf raising performances. Forty male calves were allocated to four treatments. The first and second groups consisted of weaned groups on days 35 and 70 which only considers the duration, regardless of the consumption of the concentrate. In the second and third experimental groups, 700 grams of feed consumption was taken for 2 or 3 consecutive days. The daily feed consumption of calves was monitored and weaning was performed when 700 grams of concentrated feed consumption were consecutively used for 2 or 3 consecutive days. All calves consumed daily 4 L whole milk in two meals during the liquid feeding period. They also had free access to alfalfa straw and calf grower after first week. The calves were tested at similar birth weight on the 35th and 70th days and the differences between the groups were not statistically significant. However, weaning times of the groups showed significant (P<0.01) differences varying between 25 days and 70 days. Two calves were excluded from the trial due to health problems in the weaned group considering the 2-day concentrate feed consumption. This study showed that taking advantage of concentrated feed consumption in weaning of calves can be advantageous without decreasing performance.


The discrete element method (DEM) is widely used to predict the motion over time of many particles, such as molecules or soil particles. The computational demands for DEM simulations are significant. Therefore, improved performance could address a spectrum of scientific and engineering applications. This paper proposes an accelerated implementation for the DEM using Advanced of Reduced Instruction Set Computing Machine. The method used in this research is to compare the results of the ARM versus x86 analysis. The case study refers to the investigation conducted by V. Ćmilauer using YADE programming. The results showed that the performance of ARM as a microprocessor was capable of DEM analysis. Furthermore, because the arm stands alone as a system, it runs both Ubuntu and Windows operating systems without affecting each other's performance and capabilities. Finally, the study will focus on ARM processing as future works.


Rounding forming of casing pipe with little diameter and special shape is analyzed. An irregular technology method is selected and the technology test for casing pipe is conducted.Reasonable unfolded forming and dimension is ascertained and practicable process is established. Qualified parts have been produced with simple die.


The characteristics of female roles, like beauty, background story, and behaviors, in RPG games have a great impact on consumers' consumption behavior. When the type of female characters is more popular with consumers, the sales of this game will be higher. Through investigation and research, the beauty of female characters has the greatest impact on consumers' purchase intention, while the behavior of female characters has the least impact on consumers' purchase intention.


SUMMARY Data comparing smaller rural towns, larger rural towns, and urban communities were obtained using The American Drag and Alcohol Survey. There were some significant differences among communities at the 8th-grade level, with smaller towns showing lower rates of use of some drugs. The differences were small, however, and suggest that living in a smaller town offers only slight protection against drag use for younger children. Although males have a slightly higher probability of using drugs, there were no gender by size of community interactions. Most of the differences in drug use by community size were no longer present by the time rural youth reached the 12th grade. Ten to fifteen years ago rural youth were less likely to be drag involved, but those differences have now disappeared. Substance use may have different implications for rural youth, however, as they need to drive more often and to drive greater distances and as resources for prevention and treatment are likely to be limited.


In order to train the high-quality auditing talents for the new century, we are trying to reform the traditional teaching model by improving teaching method in class, supplementing the content, applying advanced teaching equipment, creating a democratic atmosphere in teaching, innovating the way of evaluation, and heightening the students' creativeness.


A computer code has been developed for an analysis of conduction and convection heat transfer on a personal computer. FVM based on unstructured mesh has been employed for triangular and quadrilateral element. An variable of p, u, v, T, χ and e has been defined on a node (not on a center of element). The code possesses the pre-and post-processor for itself to provide user-friendly interface.


In Ming Dynasty,Li Bai's poems were inscribed,spreading on a large scale,the condition was unprecedented,not only all kinds of editions in Song Dynasty and Yuan Dynasty were reprinted,but also all kinds of selections and editions with comments uninterruptedly appeared,totaling fifty-one kinds.Many editions were supplemented many times,having a deep and far influence,becoming a base of historical data on which Li Bai's Poems were widely spread and accepted in Ming Dynasty.This paper systematically origin and development,printing and spreading of Li Bai's poems.


Health reproduction was one of important topic in health department to reach condition of health reproduction wich healthly time for a woman pregnant and birthing between 20 years old until 25 years old. When the pregnant mothers age 20 years old hook on to husband were being her couple. Husband supported were a big share to determine health status of pregnant mothers. This aim of this study is  to know correlation between husband supported with  pregnant mothers behaviour with age 20 years old during of pregnancy in Public Health Center Tlogosari Kulon Semarang. This study  Used correlations analitic research by cross sectional approaching method. Popultion this research werw woman pregant who examine at BKIA Public Health Center Tlogosari Kulon by the sample saturated tehnic thirty two respondents. Data analyze univariate and bivariate. Hypothesis was analyze test by Chi-Square test α = 0,05. This research gotten sixteen respondents (50%) supported husband with pregnancy and most of seventeen responden (53,1%) the age of woman pregnant less than twenty years old were negative behavior. Analyze test by Chi-Square test ρ = 0,005 < α = 0,05 it was showed that there is significant correlation between husband supported with  pregnant mothers behaviour wth age 20 years old during of pregnancy. Keywords :Supported husband, behaviour, pregnancy, young age


In the increasing climate aridization context, water effective use by plants is important, which is strongly influenced by photosynthesis and plant transpiration. In these processes' study, buckwheat plants have pronounced variances, manifested in ontogenesis and during the day at the leaves different tiers level, which accordingly affects the water use effectiveness by plants. The water effective use greatest' values by plants are observed in the pre-dinner hours (from 9:00 a.m. to 11:00 a.m.) during active vegetative growth and mass seed pouring (20 days flowering phase), when photosynthesis processes are active and transpiration is at an average level. As a breeding result, this buckwheat plants property is enhanced, which has a positive effect on seed productivity growth. Modern crop varieties outperform local populations by an average of 19.5% in water use terms during the flowering + 20 days phase, 19.8% in photosynthesis intensity terms, 3.4% in transpiration intensity terms, and 37% in seed productivity terms. At the same time, their resistance to air and soil drought tends to decrease, which negatively affects the stability and photosynthesis, and transpiration, and yield. On this basis, it is not considered appropriate to use the water effective use indicator by plants to assess the breeding material for drought resistance but to recommend it for the only highly productive genotypes' identification. The promising forms' selection can be carried out in the field already in the selection' early stages - the 1st and 2nd years nurseries selection.


The research on liquid crystallinity of carbon nanotubes (CNTs) is the novel and frontier subject. The liquid crystallinity is their orientation characteristic, which is from the effects of excluded volumes for CNTs and performs the typically optical birefringence. CNTs' rodlike anisotropy lies in promoting formations of various orienting liquid crystalline defects and the nanotube uniform alignments, and the liquid crystalline defects will be expected to transform into highly uniform orienting structures with actions of doping, shearing, external fields and so on. The paper mainly makes simple reviews about orienting characteristics for liquid crystalline CNTs by means of morphology characterization, emphasizing their inherent properties. Magnitudes of nanotubes make them visible under certain characterization (i.e. scanning electron microscopic characterization), as well as both of their inherent high Young's modulus and the strong attractive interaction between them make the liquid crystallinity uncommon but regular (apt to behave splaying).


Underlying the easy accessibility and popularity of amateur unmanned aerial vehicles (UAVs, or drones), an effective multi-UAV detection method is desired. In this paper, we proposed a novel radio frequency (RF) signal detection method for recognizing multiple UAVs' intrusion. The single transient control and video signal is transformed by Short Time Fourier Transform (STFT) to obtain its time-frequency-energy distribution features. To reduce the dimensionality of the RF feature vector, the principal component analysis (PCA) is applied in the signal characteristic subspace transformation. A remapped UAVs RF signal feature data is used in the training of the support vector machine (SVM) and K-nearest neighbor (KNN) algorithm for classifying the presence and number of intruding UAVs. In addition, a real-time test of UAV attacks on an airport area is implemented. The test results show that the accuracy for detecting the number of intruding UAVs is effective. This method could similarly apply to protect the public from unsafe and unauthorized UAV operations near security sensitive facilities.


Two types of cDNA encoding Mn-SOD were cloned from the green alga Spirogyra, which is located at an important position bridging from green algae to land plants in plant lineage. One, referred to as the land plant-type, encoded a protein whose sequence closely resembled those of mitochondrial Mn-SODs from land plants. The other, referred to as the algal-type, encoded a MnSOD similar to that of Chlamydomonas reinhardtii in amino acid sequence. The alignment of both SOD sequences revealed their resemblance in the transit signal region, indicating that both are mitochondria-localizing Mn-SODs. Phylogenetic analyses showed that the algal-type and land plant-type of Mn-SOD belong to separate subgroups and that the algal-type is contained in algae but not in land plants, while the land plant-type is involved in algae and land plants. Although the genomic genes of both types consisted of six exons, their exon-intron structures were completely different from each other. The structure of the land plant-type gene was identical with those of two Mn-SOD genes of Arabidopsis thaliana. Recombinant Mn-SODs of the algaland land planttype were determined to be homodimer and homotetramer, respectively. The three-dimensional structure of both types, predicted by homology modeling, showed a prominent difference at the N-terminal helices H1–H3 which may affect the quaternary structure. Thus, the present results clearly show that Spirogyra contains two types of Mn-SOD, algaland land plant-type, differing in the quaternary structure. This suggests an earlier divergence of Mn-SOD genes before the emergence of plant lineage during the course of evolution. In addition, we found a first intron-retained splicing variant of the algal-type and discuss its function in gene regulation.


The USDA released a set of reports on January 12 containing information with implications for corn and soybean prices in 2018. The National Agricultural Statistics Service (NASS) released the final estimates of the 2017 U.S. corn and soybean crops and estimates of the stocks of corn and soybeans in storage as of December 1, 2017. Additionally, the World Agricultural Outlook Board reports provided new forecasts for global supply and consumption levels during the 2017-18 marketing year. The following discussion recaps the information contained in the USDA reports and the price implications associated with them for corn and soybeans.


The lagrangian of the Kaluza-Klein theory, in its simplest five-dimensional version, should include not only the scalar curvature R, but also the quadratic Gauss-Bonnet invariant. The general lagrangian is computed and the resulting non-linear equations which generalize Maxwell's system in a quite unique way are investigated. The possibility of the existence of static solutions is presented, and the qualitative behaviour of such solutions is discussed.


The idea of intelligibility is essential within a conversation. The status of English as a global language and its emergence varieties, the notion of standard English (British and American) may no longer appropriate within the context of global communication. This leads to the importance of teaching learners to achieve intelligibility, which is more realistic and attainable rather than forcing the students to have native like proficiency. This study aimed to examine various learning habits that may affect the quality of intelligibility of EFL learners in an English Community namely GEC in Mandalika University of Education. Qualitative narrative research approach was used. The data were collected by using two instruments:(1) indirect observation by the of a native speaker acted as a rater; (2) face to face interview which aim to find out students' strategies in improving their pronunciation. The subjects of the study were five members of GEC who met a set of criteria. Among  the five students, two performed well in aspects like word stress, segmental pronunciation, and voice quality, and these high achievers showed active improvement in both receptive and productive English skills, while the predominant issue observed among these students stems from a lack of established learning habits that facilitate consistent practice, particularly in developing productive language skills, which affects their level of intelligibility in pronouncing English words


Part I. Setting the Scene: 1. Introducing UN sanctions 2. Towards a pragmatic rule of law model for UN sanctions Part II. The Evolution of the UN Sanctions Framework: 3. From Aegina to Abyssinia - a prehistory of UN sanctions 4. Sanctions under the UN charter Part III. UN Sanctions in Practice: 5. Establishing the legal basis for sanctions - identifying threats and invoking Chapter VII 6. Delineating the scope of sanctions and identifying targets 7. Fine-tuning sanctions: setting objectives, applying time-limits and minimising negative consequences 8. Delegating responsibility for sanctions administration and monitoring Part IV. Strengthening the Rule of Law: 9. Rule of law weaknesses in the UN sanctions system 10. Strengthening the rule of law performance of the UN sanctions system 11. Concluding remarks Appendix 1. Summary of policy recommendations Appendix 2. Summaries of UN sanctions regimes Appendix 3. Tables.


The present study analyzes the stance change of American Presidential political speech from the diachronic perspective,summarizes the tendency of change in the terms of the semantics and part of speech on the basis of corpus-driven and quantitative study,and probes the reasons leading to the change based on qualitative analysis.It is thought that the change of stance is influenced by politics and economics,meanwhile,and differing part of speech and semantic categories shows different tendencies of increase and decrease.


In an attempt to examine some functional characteristics of the N‐methyl‐D‐aspartate (NMDA) receptor complex, the NMDA‐evoked effluxes of endogenous dopamine (DA) and [3H]acetylcholine ([3H]ACh) were simultaneously examined in a rat Striatal slice preparation. NMDA induced release of both DA and ACh in a concentration‐dependent, Ca2+‐, Mg2+‐, and tetrodotoxin‐sensitive manner. These release responses were remarkably reduced by long‐term pre‐treatment with a low concentration of NMDA. an indication of the desensitization of the NMDA receptor. Glycine was potent in reversing the desensitization‐related reduction of DA release but failed to reverse the diminution of ACh release in the same slices. Our results indicate that the NMDA receptors regulating the release of DA and ACh are different with respect to their glycine modulatory site. This finding is consistent with a functional heterogeneity of the NMDA receptor complex in the rat striatum.


Synchrotron radiation based scanning X-ray spectroscopy (XRS) can determine both elemental concentrations and chemical binding states with high spatial resolution down to the nanoscale. Within the last decade, the need for such high-resolution analytical methods in application fields such as life science, energy storage and conversion as well as climate protection has steadily increased. In order to quantify nanoelectronics, pharmaceuticals, biomolecules and medical imaging contrast agents in biological tissue and cells, the development and adaptation of traceable methodologies are crucial. XRS can be quantitative and recent advances in a novel kind of vibration reduced X-ray fluorescence (XRF) analysis have pushed the spatial resolution towards the 100 nm regime. This could provide the missing link for quantification across the length scales. There are only a few scanning X-ray microscopes that offer XRF analysis in combination with scanning transmission X-ray microscopy (STXM) such as Elettra–TwinMic (STXM and XRF); Diamond – I08 (STXM and XRF); PETRA III – P04 AnImaX


Reflections of a Legal Historian Abstract: The need to codify law and customs in territories populated by people speaking different languages is a recurring motif throughout European medieval history. This necessity has been tackled by two different approaches favoring either linguistic mediation or integration under a common dominant language. Each produced substantial and long-lasting effects on legal culture and legal and social relations. We now wonder: what will be the impact of neglecting the methodological and cultural contributions of Italian lawyers and legal historians traditionally passed down through their native language?


List of Illustrations Persons Interviewed Foreword by Eric Foner Preface: "I'm Abbie Hoffman" 1. Bad Behavior 2. A Thousand Faces 3. Civil Rights and Wrongs 4. White Mischief, Black Power 5. Death of a Salesman, Birth of a Hippie 6. The Mythic Revolutionary 7. The Apotheosis of Abbie Hoffman 8. Busy Being Born, Busy Dying 9. Fire in a Crowded Courtroom 10. American Armageddon 11. The Longest Good-bye: 1974-1989 Epilogue: A Cautionary Note Bibliolographic Essay and Acknowledgements Bibliography Index


The JWST mission is in the process of probing the galaxy mass function at z > 10, when conceivably any delay in halo assembly due to the presence of a dwarf galaxy-scale power spectrum cutoff may drastically suppress the number of galaxies relative to the cold dark matter (CDM) expectation. We employ N-body simulations of CDM and warm dark matter (WDM) to explore how the difference in halo collapse time between these models scales with z = 0 descendant halo mass. We demonstrate that collapse begins first for the most massive haloes, and the delay in collapse time between CDM and WDM haloes correlates inversely with descendant mass. We thus infer that only present-day dwarf galaxies exhibit any difference in their assembly history between CDM and WDM at z = 10, and therefore support previous studies that have found JWST is unlikely to determine whether our Universe is better described by the CDM cosmology or the WDM cosmology.


Tamarindlls indica , native to the dry savannah of tropical Africa is an important tree species widely grown and cultivated throughout India. Tamarind fruits are used and relisbed as an important ingredient in 'curries' 'chutnies' and various other preparations. Insect pests involved in large scale damage to the various parts of the tree, are summarised. A number of sapsuckers, mealy bugs, scale insects, aphids suck the sap of the tender shoots and leaflets. Some species of caterpillars and beetles cause damage to the foliage, flowers, fruits and seeds. Control measures of various pests are also given.


The fundamental purpose of this work is to show the scenario, the factors and the circumstances that concurred around the configuration and performance of the formal indigenous groups in the state of Michoacan during the last third of the 20th century. With the case study of the so-called Purepecha Nation Organization (ONP), it is intended to demonstrate that the promoting social actors, mobilized outside the institutional instances, such as tenure headquarters and community property commissioners, to be assumed unilaterally and discretionary, as sedicent representatives of the Purepecha ethnic peoples. The ONP sought to strengthen and position itself with the generation of links and alliances with related groups of radical discursive tendencies, such as those that converged around the Zapatista National Liberation Army (EZLN) project. With this they proceeded to specify the direct interlocution with the three levels ofgovernment to demand the attention of its spectrum of disagreements, demands and expectations.


The paper specifies a machine learning model for knowledge based probabilistic consultation systems. The learning requires a training set of examples. The knowledge learned is represented as probabilistic rules. By means of simulation techniques, the performance of the learning model is studied and the rules learned evaluated. The paper indicates that the model specified is able to identify, learn and represent uncertain knowledge as probabilistic rules which can be successfully applied in consultation systems. 1. AIMS Knowledge based consultation systems are usually interactive systems designed to give advices or conclusions to problems belonging to a limited domain and based on professional knowledge represented in the system. Such systems have during the last 10-20 years been studied and implemented for practical applications in a number of fields. In many practical situations, knowledge is not exact, but uncertain. One approach taking uncertainty into account in knowledge based systems, is representing knowledge in terms of probabilistic rules. However, direct acquisition of knowledge by a knowledge engineer or from from a professional is extremely difficult when knowledge has to be represented as probabilistic rules. The reliability of a probabilistic knowledge base is crucial. Usually the reliability of acquired knowledge will not be known until after a period of practical utilization and experience with the consultation system by which time it may be concluded that 0723-712X/91 /3/181-202 $2.50©Physica-Verlag, Heidelberg


Introduction: Arterial spin labeling (ASL) is a non-invasive magnetic resonance imaging (MRI) method for measuring cerebral blood flow (CBF) in vivo. A reliable method for performing ASL would be important for diagnosing and evaluating a range of pathologic disorders. However, determination of reproducibility of ASL measurements as a function of time in healthy volunteers is critical prior to use in pharmacological and longitudinal studies of patient populations. Recently, such reproducibility studies were reported from several groups using different ASL schemes. Physiological fluctuations have been shown to be a significant source of noise in ASL based functional MRI and attempts at reduction of physiological noise in ASL fMRI has been reported. In this work, we aimed to evaluate reproducibility of perfusion MR using a pulsed ASL (PASL) sequence PICORE Q2TIPS, and compare results with and without physiological noise correction. Materials and Methods: This study was approved by local Institutional Review Board, and all subjects provided written informed consent before participating. Eight healthy subjects (27±8 years, 4 female) were scanned in two sessions with an interval of one week. To minimize effects of diurnal variations in baseline CBF, each session for same subject was acquired at the same time of same day in two sequential weeks. The MR scans of all subjects in this project were completed within 6 weeks. Scans were performed on a Siemens 3T TIM Trio (Erlangen, Germany) using a 12-channel receiver only phased array head coil in combination with a body coil for radio frequency transmission. To assess interscan variability during each session, two baseline MR perfusion scans were acquired separately in a period of 20~30 minutes while subjects underwent other BOLD fMRI scans which are not included in this report. All MR perfusion data were acquired in a resting state. Pulsation oximetry and respiration were recorded during each acquisition. In addition to perfusion scans, each session included a high resolution T1-weighted MRI for anatomical reference and a high resolution EPI whole brain scan for subsequent image registration and normalization. Brain perfusion was measured using PICORE Q2TIPS with parameters: FOV=224mm, matrix=64x64, 16 axial slice with thickness of 7mm, TR/TE=3000/13ms, TI1=700ms, TI2=1800ms. Each perfusion measurement consisted of 100 dynamics (50 control and 50 label images) plus one M0 image with a scan time of approximately 5 minutes. 3D prospective acquisition correction (PACE) was applied to correct head motion during acquisition. To compare inter and intra-session CBF maps across subjects, all CBF maps were transformed into the Montréal Neurological Institute (MNI) standard space using SPM5. A stepwise registration algorithm was used within the framework of SPM5. High resolution T1-weighted MRI was segmented to generate gray matter (GM), white matter (WM), and cerebrospinal fluid (CSF) probability maps. Partial volume effects in CBF maps were accounted for by filtering the coregistered perfusion-weighted imaging data with the probabilistic GM mask, including voxels with >75% GM probability and less than 25% WM and CSF. Reliability measured as intraclass correlation coefficient (ICC), reproducibility as within-subject variation coefficient (WSC) and coefficient of random noise were computed as described in Jahng et al.. As an alternative to the WSC, a coefficient of variation (CV) that equals SD/mean was also computed to estimate the reproducibility. A modified retrospective image based correction (mRETROICOR) algorithm was applied to reduce physiological noise in CBF images. Results and Discussion: The mean GM CBF value for all subjects was 49.03 ± 8.01 ml/(100g-min) which is in line with the results reported for GM CBF values. Repeated measures ANOVA indicated a significant main effect of subject on GM CBF, but no significant effect of time (scan). The overall GM ICC was 0.862, WSC was 0.0006 and the random noise coefficient was 0.0172. These results indicated high reproducibility of global GM perfusion between four inter and intra-session scans using PICORE Q2TIPS. The GM CV was 5.6 ± 3.3% across 8 subjects for four scans. Averaged interscan CV within session was 3.1±2.0% and the CV between sessions was 5.5 ± 4.5%. These findings suggested that the source of variance most likely reflects normal physiological variation. Comparison of results with and without physiological noise reduction using mRETROICOR, intersession CV of session 2 was slightly improved from 3.0 ± 2.7% to 2.9 ± 1.9%, although this change was not statistically significant. In conclusion, our preliminary results indicate that PICORE Q2TIPS is reliable for global GM resting baseline MR perfusion measurements. Further evaluation of physiological noise reduction in PASL to improve baseline CBF measurement is warranted.


Sensor networks are utilized in various fields as the useful system that provides the useful information to the user, by storing, processing and analyzing the various data collected from sensors. In construction of such sensor networks, by utilizing cloud PaaS for both communication server and the database server, the cost reduction and stabilization of the system can be achieved. In this paper, UDIPSN(User Decision Information Providing Sensor Network) was implemented to provide the decision information to the users by being treated as a cloud service for the location information of a moving object as well as various sensor data. Finally, the performance of the proposed system was evaluated.


In silicon several electronic levels are known which can be attributed to transition metals. Ignorance persists however about the specific nature of the defect centers. Some progress was made recently on identifying electronic levels from substitutional or interstitial lattice sites and on identifying levels from defect complexes. The sensitive Laplace DLTS technique allows us to determine depth profiles or the influence of the electrical field on the emission rate with unparalleled accuracy. Three examples will be discussed in this short review: The identification of the CoB pair, a reinterpretation of the Ti DLTS spectrum and the complex formation of interstitial Cu with substitutional Cu as the nucleation site.


The acoustic radiation into a fluid‐filled infinite half‐space from a randomly excited, thin rectangular plate inserted in an infinite baffle is discussed. The analysis is based on the in vacuo modes of the plate. The modal coupling coefficients are evaluated approximately at both low and high (but below acoustic critical) frequencies. An approximate solution of the resulting infinite set of linear simultaneous equations for the plate modal velocity amplitudes is obtained in terms of modal admittances of the plate‐fluid system. These admittances describe the important modal coupling due to both fluid inertia and radiation damping effects. The effective amount of coupling, and hence the effective radiation damping acting on a mode, depends on the relative magnitudes of the structural damping—i.e., on the widths of the modal resonance peaks and on the frequency spacing of the resonances. Expressions are obtained for the spectral density of the radiated acoustic power for the particular case of excitation by...


Abstract Background Carbapenem (Carb) minimum inhibitory concentration (MIC) breakpoints were lowered by CLSI in 2010 and recognized by FDA in 2012. Adoption of revised breakpoints is often slow, which may lead to under-reporting of Carb non-susceptibility (NS) by facilities. We compare facility-reported rates of Carb-NS ENT to the CLSI MIC breakpoints for a large nationwide collection of isolates in the United States (US) from 2016-2019. Methods All adults with a positive non-contaminant ENT culture (first isolate of a species per 30-day period from blood, respiratory, urine, skin/wound, intra-abdominal, or other) in ambulatory/inpatient settings from up to 300 US hospitals from 2016-2019 were evaluated (BD Insights Research Database). Facility-reported Carb-NS was defined as: susceptible (S), intermediate (I) or R to ertapenem (ETP), imipenem (IPM), meropenem (MEM) and/or doripenem (DOR) per commercial panels. Where available, MICs were interpreted using CLSI 2010 MIC breakpoints (µg/ml): ≤ 0.5 (S), 1 (I), ≥ 2 (R) for ETP and ≤1 (S), 2 (I), and ≥ 4 (R) for IPM/MEM/DOR. For evaluable ENT isolates we compared susceptibility results as reported by the facility to CLSI MIC breakpoints. Results Overall, 77.4% (937,926/1,211,845) and 90.6% (2,157,785/2,381,824) non-duplicate ENT isolates with facility-reported susceptibility results also had interpretable MIC results for ETP and IPM/MEM/DOR, respectively (Tables). ETP S rates were 99.3% and 99.1% as reported by facilities and using CLSI criteria, respectively. S rates of other Carbs were 98.9% and 98.4% by facility reporting and CLSI criteria, respectively. Systematic application of CLSI breakpoints under-reported EPT-I and –R isolates by 24.2% and 16.4%, respectively, and identification of IPM/MEM/DOR-I and –R isolates by 31.3% and 22.7%, respectively. Conclusion Systematic application of CLSI breakpoints in 2016-19 would have had minimal impact on ENT S rates in the US. However, facility reporting failed to identify 18.8% of ETP I or R and 26.5% of IPM/MEM/DOR I or R isolates. The clinical implications of this observation are unknown. Facilities should know their local epidemiology, decide if under-reporting might be an issue, and assess if there is any impact on their patients. Disclosures Vikas Gupta, PharmD, BCPS, Becton, Dickinson and Company (Employee, Shareholder) Kalvin Yu, MD, BD (Employee) Jason M Pogue, PharmD, BCPS, BCIDP, Merck (Consultant)QPex (Consultant)Shionogi (Consultant)Utility Therapeutics (Consultant)VenatoRX (Consultant) Janet Weeks, PhD, Becton, Dickinson and Company (Employee) Cornelius J. Clancy, MD, Merck (Grant/Research Support)


The histology microtome section technique was used to observe the strcture of neurosecretory of eyestalk in Procambarus clarkia under light microscopes and study the distribution of complex of X organ and sinus gland.The complexus of X organ and sinus gland was the main part of the neurosecretory of eyestalk.The X organ,which contained type I~VI neurosecretory cells,was located optic ganglion and was single nerve cell.The type and amount of I~VI neurosecretory cell had difference in different growth stages.Sinus gland was on the inside edge of dorsal to the junction of the terminal medulla and internal medulla.The gland was composed of its wall and blood sinus.The wall contained axon terminals of neurosecretory cells,glial cells and small blood sinus.


Contents Preface * Pricing: The Forgotten "P" * The Growing Importance of Pharmaceutical Pricing * Prices, Politics, and Problems--A Pricing Philosophy * Pricing Flow and Terminology * Price Decision Making * The Role of Price in the Decision to Purchase, Prescribe, or Use Pharmaceuticals * The Pharmaceutical Pricing Research Process * The Value of a Pharmaceutical Product * Pharmaceutical Pricing at the Change of Millennia * Index


Summary. Thin layer two phase acrylamide gel electrophoresis was used for separation of fibrinogen and fibrin degradation products which were subsequently quantitated by scanning. The use of 6 m urea in the spacer gel greatly improved separation. Three main fibrinogen fragments X, Y and D and minor fragments E1, E2 and E3 were identified. During plasmin digestion of fibrinogen, Fragment X gradually decreased and Fragment D increased. The concentration of Fragment Y was rather low as would be expected of an intermediate product in the conversion of X to D. At various times of proteolysis, there was good agreement between the level of Fragment X determined by electrophoresis and the amount of protein precipitated at low concentration of protamine sulphate (PS) from the digest pretreated with thrombin. The study supports the concept of two varieties of Fragment X, one with fibrinopeptides (Xfp)—in fibrinogen degradation products (FDP)—and one devoid of fibrinopeptides (X°)—in fibrin degradation products (fdp). During electrophoresis without urea, Fragment X° undergoes extensive polymerization in the slots and gel because of its dissociation from complexes with Fragments Y and D. In the presence of urea, Fragment X° of the early fibrin digest had slower electrophoretic mobility than Fragment Xfp. The mobility of other fibrinogen fragments was not affected by thrombin.


The spatio-temporal modeling problem from the input and output measurements for distributed parameter processes under unknown circumstances is investigated. The traditional Wiener modeling is extended to nonlinear distributed parameter systems with the help of the Karhunen−Loeve (KL) decomposition. The input is a finite-dimensional temporal variable, whereas the spatio-temporal output of the system is measured at a finite number of spatial locations. First, the measured output is used to construct a finite dimensional approximation of the system output which is expanded in terms of KL spatial basis functions. Subsequently, the temporal coefficients are used to identify a Wiener model. The identification algorithm is based on the least-squares estimation and the instrumental variables method. The simulations for parabolic and hyperbolic systems are presented to show the effectiveness of this spatio-temporal modeling method.


The effect of amla powder supplementation on heat stress and immunoglobulin (Ig) levels of summer stressed buffaloes were investigated. The study was carried out with 24 apparently healthy Murrah buffaloes during pre-summer and summer seasons. The animals were divided into 3 groups of 8 animals each viz. Pre-Summer group (Group I); Summer Control group (Group II); Summer Treatment group (Group III). Group III animals were supplemented with amla powder @ 200 mg/Kg body wt./day for 30 days. In summer stressed buffaloes (Group II), there was a significant rise in erythrocytic lipid peroxidation level and superoxide dismutase activity along with a decrease in plasma IgM and increase in IgG levels. Supplementation of amla powder to summer stressed buffaloes was able to lower lipid peroxidation levels and superoxide dismutase activity coupled with the increase in IgM and decrease in IgG levels. It was concluded that amla powder supplementation can ameliorate the adverse effects of summer stress on humoral immunity in Murrah buffaloes.


For high-performance microwave absorption materials, component integration, structure tailorability and light weight are of practical significance. Herein, a new three-dimensional magnetic composite, namely carbon nanotubes (CNTs)-intercalated nitrogen-doped graphene (N-GN) embedded with Fe2O3 NPs (referred to as Fe2O3/N-GN/CNTs), were fabricated by a solvothermal method for use as synergistic microwave absorbers. Electronic microscopy investigation shows that the Fe2O3 NPs, which formed in situ, are uniformly dispersed on the N-doped graphene nano-sheets without aggregation and that the CNTs have been successfully inserted into the layers of nano-sheets. In addition, X-ray diffraction patterns (XRD), Fourier transform infrared spectra (FTIR), X-ray photoelectron spectroscopy (XPS), Raman spectrometry and a vector network analyzer (VNA) were used to investigate the structure, chemical composition, and electromagnetic parameters of the resulting Fe2O3/N-GN/CNTs composite. Taking advantage of the synergistic effect between Fe2O3 nanocrystals with magnetic loss and N-GN/CNTs with dielectric loss, the 3D Fe2O3/N-GN/CNTs composite shows excellent microwave absorption capabilities with highly efficient performance. A maximum reflection loss of −45.8 dB can be achieved at 9.32 GHz with a matching thickness of only 3 mm, and the effective absorption (below −10 dB) bandwidth reaches 14.5 GHz (3.5 to 18.0 GHz). The excellent microwave absorption of the as-prepared composites can be related to the integrated characteristics of good impedance matching and Debye relaxation, high attenuation, strong dipole polarization and interface polarization. Therefore, these results indicate that the newly designed Fe2O3/N-GN/CNTs composite is an ideal candidate for use as a synergistic microwave absorber to address electromagnetic pollution.


The Constitution of Lesotho is regarded as liberal, with the separation of powers of the executive, judiciary and legislature, but provision was made for institutions to oversee the exercise of such powers. One of these is the Office of the Ombudsman, which has wide-ranging powers to investigate malpractice in public administration and to make recommendations for remedial action. These powers notwithstanding, there is a paucity of judicial precedent and scholarship on the binding nature of the remedial action of the Ombudsman. The main question is whether the remedial action of the Ombudsman is binding, which this article seeks to investigate and determine whether South African jurisprudence could be helpful in the case of Lesotho. The binding nature of the Public Protector's remedial action under the Constitution of South Africa has been a subject of considerable judicial and scholarly engagement in recent times. While the subject is still yet to be settled in South Africa, it nevertheless has developed principles that could assist in both the interpretation and reform of the Ombudsman's powers in Lesotho.


The research objective was to determine the ability of teachers to create instructional media in stimulating the sensitivity of early childhood in PAUD Monapa, Palangga District, Konawe Selatan District.  The subjects of this study were two teachers and the principal and the object was 15 students in group A. Data collection techniques used observation and interviews and documentation which were processed and analyzed through qualitative descriptive techniques.   Description of the teacher's ability to make learning media in PAUD Monapa, Palangga District, Konawe Selatan Regency.  The steps taken in making media are determining what media will be made, providing tools and materials, arranging steps for making media and how to convey it to students.  The supporting factors are media that are made from scrap or used materials so that they are easy to get, while the inhibiting factor is that the school environment is still far from urban areas so it is difficult to get the tools used, but creative teachers use  used materials or waste materials in making media and materials.  this is very easy to get.  The media created by the teacher aims to stimulate children's cognitive.  Keywords: Teacher's Ability to Make Learning Media, Children's Cognitive


An evaluation of bridge quality is important to plan maintenance activities, take correct maintenance countermeasures, and ensure the safety of bridge services. To help fulfill the requirements for the management of high-grade maintenance of highway bridges, a comprehensive evaluation system of bridge maintenance quality is presented. The system consists of a method to evaluate bridge condition and road–bridge adaptability. On the basis of expert survey results, weights for all indices were calculated. A highway category correction factor illustrates the significance of bridges located at various highway grades. A comprehensive evaluation model for bridge maintenance quality was designed. A ranking of criteria and maintenance countermeasures is presented. An example to validate the model is illustrated on the basis of the contrast between the evaluation results derived from the models and the experts, respectively.


It stands to reason that the greatest part of commentary on the subject of sound and film has concerned itself with the only slightly narrower subject of sound in film-or, simply, sound film. Still, a number of worthwhile areas of investigation lie in the periphery of the sound and film discourse (the use of live narrators in early film exhibition, for example, or the occurrence of audience vocality in certain screening contexts), and others will presumably come to light. Among these projects is the present essay, a comparative theorized history of narrative cinema and recorded sound, the latter in its guise as home entertainment. The emphasis will be on the subject of realism, and I proceed from the hypothesis that the realism of these media may be traced not only (or even chiefly) to the immanent properties of their finished artifacts, but at least equally to a commercially generated realist longing constantly reinscribed in their popular reception. My interest is in the relation between that process, by which a predisposition to realism is created, and the credentials which the two media at hand may meaningfully claim as instruments of realism. Within certain limits, in other words, I shall examine the institutional behavior of each in the context of its technological properties. The inquiry will thus have both synchronic and diachronic aspects, using the strategy of comparison between cinema and phonograph in the hope of contributing to a general understanding of the realist imperative which seems to govern the receptions of these and other media. By "popular reception" I mean the epistemological tenor of the discourses of journalistic criticism, promotional material, and the massive, all-important network of public and private oral communication. These three modes of discourse are, respectively, difficult, difficult, and impossible to empiricize meaningfully, even in a much larger context whose primary object is their detailed study; yet their roles demand consideration in any functional account of the tenacious realist mechanisms of which they are parts. In the interest of historiographical clarity I wish to be explicit about the macroscopic scale of parts of my argument. Even where the almost infinite historical record is engaged closely, the act is one of selection and storytelling. Readers who respond skeptically to the observations made at this level are of course at liberty to evaluate the attendant theoretical elaborations accordingly. The fullest name I might give to the filmic object of my attention would be continuity realist narrative, a term chosen only in part for its resonance with such terms as "classical" or "dominant." Certainly the American orientation of


This study explores whether market competition between firms owned and run by managers favors overconfident managers. We study this question in a simple duopoly setting with differentiated products ...


An abstract of the thesis of Connie Allene Freed for the Master of Science in Speech Communication: Speech and Hearing Science presented May 9, 1996. Title: Effects of Posttraining Maintenance Sessions on Aphasic Subjects' Verbal Labeling For many years, treatment for word retrieval deficits has involved the use of various cueing techniques to help trigger retrieval of target words. Research has shown that accuracy for future retrieval of target words is best achieved by training subjects with semantically based cues. Personalized cues that are created by the subjects themselves to help remember a target word have been shown to be the most effective of the semantically based cues. However, even with the use of personalized cues, accuracy for naming tasks has been found to decrease once training is completed. Current research in memory indicates that, for normal subjects, techniques that facilitate future recall of information include testing, additional study, overlearning, and distributed practice. This research examined the influence of posttraining maintenance sessions on the long term memory of subjects with aphasia. The goal was to compare the effect on naming accuracy for stimuli (a) presented in two additional training sessions (b) presented in one additional session, (c) not presented in any additional sessions. Additional sessions presented opportunities for testing, study, overlearning, and distributed practice for selected stimuli. Three adult male subjects with moderate aphasia created their own cues to help remember 30 pictures of famous characters. During training sessions, these cues were presented to trigger name recall. Following the end of the 3-week training period, the 30 pictures were divided into groups of 10 cards called, A, B, and C. There were two additional training sessions for A, one for B, and none for C. A probe following the last session showed that for two of the subjects, the addition of posttraining maintenance sessions acted to enhance naming accuracy, and two sessions resulted in much higher accuracy than one session. This is consistent with research with normal subjects and suggests that short intermittent training sessions can help maintain naming accuracy with subjects with aphasia. 2


Advanced Pulse-Shape Analysis and Implementation of Gamma-Ray Tracking in a Position-Sensitive Coaxial HPGe Detector by Austin Lee Kuhn B.S. (United States Merchant Marine Academy) 1997 M.S. (University of California, Berkeley) 1999 A dissertation submitted in partial satisfaction of the requirements for the degree of Doctor of Philosophy in Engineering - Nuclear Engineering in the GRADUATE DIVISION of the UNIVERSITY OF CALIFORNIA, BERKELEY Committee in charge: Professor Stanley G. Prussin, Chair Professor Jasmina L. Vujic Professor Eugene E. Haller Fall 2002


The development degree of the land market may directly influence the allocation and use efficiency of the land resources.Based on a discussion of the connotation of the "maturity degree of rural land market",this article constructs an evaluation indicator system,estimates the development degree of the rural land market in four zones of Chongqing and makes a comparative analysis of these zones.The research shows that on the whole the development of rural land market in Chongqing is at a medium stage,with striking difference among the 4 zones,which are in the order of the Metropolitan area the 14 counties around it Northeastern Chongqing Southeastern Chongqing.The maturation degree of land market in the Metropolitan area is of the maturing type while that of the rest is of the developing type.It is concluded from the above result that the factors which influence the maturity of rural land market in different zones of Chongqing are the development level of the economy,the volume and proportion of agricultural labor,the education level of labor and the degree of land use.Finally,in order to promote the healthy development of rural land market in future practical work,the paper puts forward some strategies for the development of rural land market in different zones of Chongqing.


OSOWSKI, NICOLE LYN. The Influence of Token Status Induced Stereotype Threat on Memory Performance in Older Adults. (Under the direction of Thomas M. Hess, Ph.D.) The purpose of the current research was to investigate how contextual features of a situation affect cognitive performance. Specifically, this research explored the role that a social characteristic of the testing situation, group composition, had on memory performance. The study tested older adults (N=72) between the ages of 65 and 75 who were evenly divided into three testing conditions. In the minority status condition, one older adult was tested with two younger adult confederates whereas in the majority status condition, older adults were tested with two similarly aged individuals. The third condition involved individualized testing. It was expected that older adults would experience stereotype threat in the minority status condition and that this would result in poorer performance on a memory task relative to those in the majority status and alone conditions. Contrary to expectations, memory performance did not significantly differ between the three conditions, providing no support for the hypothesis that group composition at testing would be related to stereotype threat . In addition, no evidence was found that the hypothesized moderators (stigma consciousness, value placed on memory) and mediators (anxiety, evaluation apprehension, strategy use) were related to threat-based effects. THE INFLUENCE OF TOKEN STATUS INDUCED STEREOTYPE THREAT ON MEMORY PERFORMANCE IN OLDER ADULTS by NICOLE LYN OSOWSKI A thesis submitted to the Graduate Faculty of North Carolina State University in partial fulfillment of the requirements for the Degree of Master of Science


Previous work in our group focused on the development and refinement of polarizable charge equilibration (CHEQ) force fields for use in molecular dynamics (MD) simulations of phospholipid bilayers. We present results to further validate these force fields by extending to simulations of a model DPPC-water monolayer. Several physical and electrostatic properties have been calculated for comparison with previously reported experimental and computational studies including component density profiles, deuterium order parameters, surface pressure and tension, and the monolayer-water potential difference relative to a pure water-air interface. Having validated the CHEQ force field for use with both lipid bilayer and monolayer systems, as well as having identified areas where improvement is needed, we apply an intermediate, revised version of the force field to study the energetics of an arginine side-chain analog, methyl guanidinium, as it crosses a DPPC lipid bilayer. Combining umbrella sampling MD simulations with the Weighted Histogram Analysis Method (WHAM) for unbiasing probabilities, we compute a potential of mean force (PMF) for the reversible transfer of methyl guanidinium from bulk solution to bilayer center. Decomposition of the PMF in component contributions allows us to investigate the role of lipid and solvent to the energetics of permeation. Finally, through a series of simulations in which water is first prevented from entering the bilayer center where methyl guanidinium is restrained and then, after equilibration, allowed to enter the bilayer, we find that water permeation into the bilayer is required for the deformation of individual lipid molecules and permeation of ions into the membrane.


This paper is concerned with the vertical vibration of a flexible foundation resting on a saturated layered soil half-space that consists of a dry soil layer and an underlying semi-infinite saturated soil. The problem is of the mixed boundary value type and, by means of the Hankel transform technique, the determination of dynamic compliance coefficient and contact stress distribution leads to a pair of dual integral equations. These equations are then reduced to a Fredholm integral equation of the second kind, which is solved by standard numerical procedure. Some limiting cases existing in the literature are revisited to validate the accuracy of the present solution. Extensive numerical results are presented to illustrate the influences of the thickness of the overlying dry soil, the foundation flexibility, and the shear modulus ratio between dry and underlying saturated soils on the dynamic responses of the flexible foundations.


This article highlights the complexity of factors that may be seen to have adversely affected the career of a working‐class woman municipal councillor in interwar Britain. It examines the effect that poverty had on the political position of Alice Arnold, Labour councillor in Coventry from 1919 until 1955, and in addition considers whether, despite her popularity with the electorate, her isolation within the Labour Party and on Coventry City Council was also the result of gender, social status and radical politics. Whilst many Labour councillors moved away from the poverty of their upbringing, either through employment or marriage, Arnold, who was single, carried hers with her throughout her life. I argue that a consequence of this, along with her unflinching socialist stance, made Party and Council colleagues unable to 'place' her. The feeling that she was 'everyone's poor relation' was widespread enough to have been preserved in historical accounts of her life that repeatedly refer to her as a poor, eccentric woman, whilst her political achievements have been forgotten.


Stereoselective Conversions of t-Butyl rac-, (R)-, or (S)-5-Alkylidene-2-t-butyl-3-methyl-4-oxo-1-imidazolidinecarboxylates (Chiral 2,3-Dehydroamino Acid Derivatives) and Preparation of Some Nonproteinogenic Amino Acids

The reacivity of the alkylidene derivatives 1–11 specified in the title and prepared in two operational steps from commercially available Boc-BMI and aldehydes is investigated. – According to high-field 1H-NMR analysis of the crude products, additions of HH and DD (catalytic hydrogenation, products 12–20, of RH (BF3-activated R2CuLi/LiI and protonation, products 21–29), and of Cl2C (CHCl3/NaOH, products 33, 34) occur with complete selectivity from the face opposite to the t-butyl group. The doubly unsaturated carbonyl derivative 11 reacts with dibutyl cuprate in the δ position, again with formation of a single diastereomer 32, while trifluoroethylidene-Boc-BMI 3a is reduced to the difluoro analogue 30 by this cuprate. – Li dienolates are generated by deprotonation with LDA of the ethylidene (2a) and butylidene compound 4a; subsequent alkylations (with primary and secondary halides, products 35–41) and hydroxyalkylations (with aldehydes, products 42–44) lead to single products of electrophilic attack in the a carbonyl position (C-5 of the imidazolidinone ring) under kinetic control. On the other hand, reaction of the 2a-derived dienolate with benzaldehyde under equilibrating conditions furnishes the four possible (E/R, E/S, Z/R, and Z/S) γ adducts 45–48. – A combination of methods – 1H- and 13C-NMR spectroscopy, NOE measurements, spectroscopic analogies, chemical correlation (with authentic samples or by spectroscopic or optical comparison), and X-ray analysis (Table 1, Figure 1, Schemes 1 and 2) – is used to assign the product configurations and thus the stereochemical course of the reactions. Some unusual amino acids (50–52, 54, 55) are prepared by hydrolysis of the corresponding imidazolidinones.


T HE twenty-fourth annual meeting of the Pernsylva: ia Historical Association opened with a luncheon on Friday, October 14, 1955, in Hogg Hall, Lafayette College, Easton, Pennsylvania Following a delicious meal at which fifty-six members and guests were present, Dr. Ralph C. Hutchison, President of Lafayette College, welcomed the Association on behalf of his institution, extending to the Association the hospitality and facilities of the colleg-e. Dr. Edwin B. Coddington, chairman of the Local Arrangements Committee, also welcomed the Association in the name of the Northampton County Historical and Genealogical Society, calling attention to the fact that next year the Society would be fifty years old. Dr. Philip S. Klein, President of the Association, acknowledged these words of welcome, thanking both the college and the Northampton Society for their willingness to act as cohosts for the twenty-fourth annual meeting. The principal speaker at the luncheon session was to have been Dr. Amos A. Ettinger, presently a visiting professor at Southeni Methodist University. Although an unexpected illness prevented his appearance, he had sent his paper, entitled "The Lehigh's Roclk) Rapids," to Mr. Melville J. Boyer, program chairman, who real it skillfully. In this paper, Dr. Ettinger traced the origin of the Lehigh's name, surveyed the river's importance to eastern Pennsylvania, and described its winding course in beautiful prose. Only a romantic, such as Dr. Ettinger, could have spoken thus of tl Lehigh, its history, and its significance. The Friday afternoon session convened at 2:30 o'clock in Roo", 101, Kirby Hall. Professor Victor L. Johnson of Muhlenberg College presided and introduced the first speaker, the Hon. Henry L Snyder of Allentown. In his paper, "Unique Aspects of the Trials of John Fries," Mr. Snyder re-told the famous story of Fries and


The Surgery Trial in Intracerebral Hemorrhage (STICH) suggested that patients with a superficial hemorrhage close to the cortex could potentially benefit from surgical evacuation. To examine this issue directly, researchers have now conducted the STICH II trial. They randomized 601 patients with an intracerebral hemorrhage (ICH) within 1 cm of the cortical surface to surgical evacuation (aiming for within 12 hours of randomization) or initial conservative treatment (with surgery allowed in case of clinical deterioration). Patients …


Each student that enrolls in vocational education programs and to who subsection (b) applies shall receive-(1) assessment of interest, abilities and special needs of such student with respect to completing successfully the vocational education program. (Title II Basic State Grants for Vocational Education ; Part A Vocational Education Opportunities; Section 204(c) Criteria for Services and Activities for the Handicapped and Disadvantaged)


According to the application of Beidou Satellite Terminal Positioning System that is tested in different latitudes,weather conditions,tectonic geomorphology and the conditions of moving in East Kunlun Mountain,application characteristics and inadequacy of this system in the field geological investigation are summarized and its development is also stated.The result showed that the satellite terminal positioning system had improved the efficiency,protected geological fieldworkers' safety,which played an important role in field operations management and emergency services.Currently the positioning accuracy is not just as one wish,for the positioning signal had been affected by tectonic geomorphology,weather and the way fieldworkers moved,and this is the key problems to be solved in the future.


The book edited by Nouri Gana is one of the more complete and exhaustive original works that have been published on Tunisia since the riots of 2010–2011. The effort made by the authors is twofold. On the one hand, the decision has been made to cover almost exclusively a very short time period, namely to retrace the social, political and economic dynamics that have contributed to the Tunisian revolution and continue to shape the country's fate. On the other hand, such a relatively short historical period has been treated with a rare depth and a meticulous selection of the issues and dynamics that combine to make Tunisia a case study so interesting to those who analyse the Arab world today. The element that makes this book so original and exhaustive is a clear and well-executed division of the work into three main sections. The first—what could be called the most 'historical' section (Chapters 1–4)—provides a framework for the context in which began the protests that eventually led to the fall of Zine el-Abidine Ben 'Ali and his escape from Tunis. The second part (Chapters 5–8) is aimed at analysing the role of key actors and factors that have been involved in the riots, with particular reference to the role of trade unions and the socio-economic conditions of the country, to social media and traditional media and to the cultural landscape, especially the visual arts (music and films). Finally, the third part (Chapters 9–12) ferries us to the future of what, up to now, can rightly be called the only success story among the democratisation processes that are gradually catching on in some areas of the Middle East and North Africa. No particular political, economic or social aspect of contemporary Tunisia is omitted: from the importance—and, according to the interpretation given in the work, at some stage intrusiveness (see Chapter 1, authored by EmmaC.Murphy)— of relations with international financial organisations, to the relationship with France (in Chapter 4, Amy Aisen Kallander argues that the French diplomatic alliance with Tunisia over recent decades, based on neo-colonial relations, encouraged the detriment of democracy) and the relationshipwith theUnitedStates; from the role played by religion in the public life of Tunisia—amatter of debate par excellence within the current Tunisia on its way to democratisation (discussed in Chapter 2 by Kenneth Perkins)—to the weight of civil society in identifying the relevant issues of the protests, and later in steering outcomes; up to the activism of women and the emergence of salafism which, in its most radical forms, has the potential to threaten the success of the Tunisian transition to a democratic system. The latter issue is well treated by Francesco Cavatorta and Fabio Merone British Journal of Middle Eastern Studies, 2014


Review(s) of: Selected poems: 1975-1990, by Ken Bolton, (Penguin, 1992, $14.95); Poems at play, by Dennis Davison, (English Department, Monash University, 1992, $7.00); One day she catches fire, by Kristin Henry, (Penguin, 1992, $14.95); Flying fish: Selected poems, by Robin Loftus, (Nimrod, 1992); Lozenge: Poems, by Kathy Allen, Mande Bijelic, Julie Hunt, Alison Symes (Cornford Press, 1992, $13.95); Once father and god, by Mal Morgan, (Five Islands Press, 1992); Satellite link, by Tony Page, (The Jacaranda Press, 1992); Changing House, by David P. Reiter, (The Jacaranda Press, 1991), Red Centre journal: A journey in two parts, by Kevin Roberts, (Wakefield Press, 1992).


Urinary selenium concentrations are known to be greater in workers exposed to elemental mercury vapor (hereafter refered to as mercury vapor) than in non-exposed control subjects,1) and a worker exposed to mercury vapor was found to have an elevated urinary selenium leve1.2) These two reports suggest that an increase of urinary selenium excretion may occur as a result of mercury vapor exposure. However, experimental data regarding the interaction between mercury vapor and selenium have yielded ambiguous results about the retention and elimination of selenium due to mercury vapor exposure,3,4) and the decrease of selenium excretion due to mercury in the form of mercuric mercury (Hg2+ ) .5,6) In this study, we measured urinary mercury and selenium in workers with or without exposure to mercury vapor to determine whether or not urinary selenium excretion was increased as a result of mercury vapor exposure. Urine samples were collected from 141 workers, 71 men and 70 women, whose extent of ex-


Better methods are needed for mapping agricultural drainage pipe systems. Prior research on small test plots indicates that ground penetrating radar (GPR) is oftentimes capable of detecting buried drainage pipes; however, the feasibility of employing this geophysical technique in larger field areas has not been adequately evaluated. Ground penetrating radar integrated with a Real-Time Kinematic (RTK) Global Navigation Satellite System (GNSS) may be an effective and efficient means of mapping drain lines within agricultural fields. Therefore, GPR-RTK/GNSS was tested in three agricultural settings; with Site 1 and Site 2 located in Beltsville, MD, USA and Site 3 near Columbus, OH, USA. Soils at the three sites ranged from silty clay loam to loamy sand. A GPR unit with 250 MHz antennas was used to detect drainage pipes, and at Sites 1 and 2, a physical GNSS base station was utilized, while a virtual base station was employed at Site 3. The GPR-RTK/GNSS configurations used in this study delineated a complex rectangular drainage pipe system at Site 1, with one set of drainage pipes oriented southwest-northeast and a second oriented southeast-northwest. At Site 2, a herringbone drain line pattern was outlined, and at Site 3, random drain lines were found. When integrated with RTK/GNSS, spiral or serpentine GPR transects (or spiral/serpentine segments of a GPR transects) were utilized to provide insight on drain line directional trends. Consequently, given suitable field conditions, GPR integrated with RTK/GNSS can be a valuable tool for farmers and drainage contractors needing to map subsurface drainage systems.


This paper will give an overview of the Australian Synchrotron Project (ASP) storage ring and injection system [1]. The ASP storage ring is a 3 GeV machine with 14 identical cells and a circumference of 216 m. The unit cell is based on a Double Bend Achromat (DBA) structure. The present design of the magnet lattice and the results of simulations pertaining to the storage ring performance are presented. The facility is expected to be in operation by March 2007 [2].


Objective
To study the effect of applying rehabilitation nursing intervention for breast cancer patients.

Methods
By convenience sampling, 79 breast cancer patients in Daqing LongNan Hospital of Heilongjiang Province were selected from March to November of 2018 as participants in this study and divided into the observation group (n=39) and control group (n=40) by random number table. The control group received conventional nursing care while the observation group received the combination nursing care of the conventional and rehabilitation nursing intervention. The two groups were compared in the rehabilitation effects, anxiety and depressive emotion and quality of life.

Results
The observation group had better upper limb function than the control group after intervention with statistical difference (P<0.05) . The observation group had lower score in anxiety and depression than the control group after intervention with statistical difference (P<0.05) . The observation group had higher score in each dimensions of life quality than the control group after intervention with statistical difference (P<0.05) .

Conclusion
Rehabilitation nursing intervention for breast cancer patients is of high clinical value and can be widely applied.

Key words:
Breast neoplasms; Anxiety; Depression; Rehabilitation nursing; Quality of life


This report highlights the case of cystic adventitial disease of the left popliteal artery in a 45‐year‐old male patient. Imaging modalities confirmed the diagnosis and high resolution MRI found a cystic connection to the adjacent knee joint. The evolution was unusual with spontaneous regression of the symptoms.


This chapter outlines the several scales at which material arrangements of architecture, urbanism, and territory are bound up with surrounding legal contexts. Using these three scales, the chapter elucidates the reciprocity of law and space, a reciprocity through which the law is spatialized by its distributions across places and locales and space is differentiated and particularized by law. A courtroom, for example, is a physical space and a locus for legal process; a city street is a material conjunction of objects and persons as well as a concretization of codes and regulations; a territorial boundary is a demarcated section of land and an inscription of legal permissions and constraints. These different mediums of social inhabitation, of such different scales, are imperfectly coordinated, yet with their often inextricable connections they comprise a domain of great relevance to law and humanities. Within this domain, which consists of disciplinary intersections of law with architectural history and theory, with geography, and with urban studies, the complex interactions of norms with the contingencies of myriad cultural productions come into view. Regulatory instruments, plans, buildings, pillars, rooms, regions, and other arrangements can be seen to function as techniques for the projection and translation of juridical and spatial orderings.


Environmental deterioration has taken a long time to become a global concern since it was first articulated as a scientific problem. Environmental degradation was formerly considered an abstract idea, but it is now far from abstract, defining people's lives. Thrilling weather events and increased variability in weather patterns have severe consequences for societies that rely on Land, lakes, and seas for food and income. Due to insufficient knowledge, citizens' responses to environmental deterioration have been limited by a fundamental lack of relevant, helpful information for Northern residents. In the north, the civilized world's heavy media coverage and public awareness campaigns have been lacking, particularly outside major urban areas. The extent to which Nigerians comprehend environmental degradation will determine how they respond. Unfortunately, little is known about how Northerners perceive and comprehend environmental degradation today. By utilizing the Biblical wisdom revealed in Leviticus 25:1-5, this article aimed to be a voice and source of knowledge for the targeted audience. The study used the lessons learned from the literature to help Northern Nigeria address its existential dilemma. A diachronic approach to the text is used, with the historical-grammatical method fully complemented.


Objective: This case report will discuss the experience of using percutaneous drainage as an alternative of open surgery in pararenal abscess therapy. Case(s) Presentation: 61 years old woman complained of left flank pain 6 months before with septic condition. Physical examination revealed tenderness and mass in the left flank region with leukocytosis. Abdominal Computed Tomography (CT) Scan results showed a left lower pole pararenal abscess, severe hydropyonephrosis and ureteropelvic junction stones. Percutaneous abscess drainage and percutaneous nephrostomy was performed with an 18Fr troicart using ultrasound guidance. Discussion: The pus culture showed Escherichia coli bacteria. After three days of operation and intravenous antibiotics, the patient experienced clinical improvement. Outpatient follow-up showed decreased drain production from percutaneous abscess drainage and clear yellow liquid production from percutaneous. Percutaneous nephrolithotomy was performed for the management of stone evacuation. After going through the whole procedure, there is clinical improvement of patient. Conclusion: Percutaneous drainage is an alternative option in the management of perirenal abscesses. Compared to open surgical drainage, the percutaneous technique provides a minimally invasive process, shorter length of stay and more effective costs. This procedure has also shown good clinical improvement in patients.
Keywords: Minimal invasive, pararenal abscess, percutaneous drainage.


We have developed the agricultural simulation model applying Multi-Agent Systems (MAS) and demonstrated the possibility of the model for prediction of the structural changes in agriculture for organizing regional agriculture systems at the Y community, Kanzaki town, Hyogo prefecture.In this research, we carried out a sensitivity analysis on some crucial parameters such as rate of decrease in rice price, machine operation fees and land rent, labor efficiency of machine operations and the level of cooperativeness about land lease. As the results of this analysis, it became clear that the amelioration of cooperativeness about land lease would bring distinct effects to the future changes in agricultural structure and farmland use.


Presented here are the results of a theoretical study aimed at investigating the effects of interactions between individual catalyst particles in a fixed-bed reactor. For tractability of the mathematical description and of the results, the model is based on a simplified picture in which spherical catalyst pellets are aligned in a single column along the axis of a tubular reactor. Further, the model is based on a first-order exothermic reaction and a mixing-cell description of the fluid flow. Numerical solutions are presented for cases of two and four active pellets Among the results are complex bifurcation diagrams and large steady-state multiplicities attributable to the discrete particle model. These features are strongly dependent on parameter values—most importantly on the distribution of catalytic activities when there are slight variations from a mean activity level. The results, though based on an idealized study model of the catalyst arrangement, apply conceptually to more realistic situations, an...


This study examined the developmental changes in 4th,5th ,6th graders' attachment security to parents and the respective role of child mother and child father attachment on children's different domains of social functioning. Results showed that children's perceptions of parental availability and attachment to mother decreased significantly with age. Attachment to mother and father differs ,too. While children's access to parents and attachment to father didn't differ as a function of age. It was found that social behaviors and nominations of best friends were better predicted by the quality of child mother attachment than by that of child father attachment. Friendship quality and social anxiety were related to attachment to both mother and father. Children with two secure attachments had advantage over others.


This paper has examined Papua New Guinea's historical economic growth patterns through a simple growth accounting framework. The analysis shows that swings in growth are mostly accounted for by a significant slowdown in capital input and lower Total Factor Productivity (TFP) growth. It also suggests that raising real GDP growth will require increases in both investment levels and productivity. With a ratio of investment to GDP of 13 percent during the last decade, significantly higher productivity growth and investment will be needed to sustain GDP growth rates at 5 percent or higher. The historical performance also indicates that, in the absence of structural reforms and strong institutions, higher rates of productivity growth will be hard to achieve.


Abstract: The identification of significant underlying data patterns such as image composition and spatial arrangements is fundamental in remote sensing tasks. Therefore, the development of an effective approach for information extraction is crucial to achieve this goal. Affinity propagation (AP) algorithm is a novel powerful technique with the ability of handling with unusual data, containing both categorical and numerical attributes. However, AP has some limitations related to the choice of initial preference parameter, occurrence of oscillations and processing of large data sets. This paper evaluates the clustering performance of AP algorithm taking into account the influence of preference parameter and damping factor. The study was conducted considering the AP algorithm, the adaptive AP and partition AP. According to the experiments, the choice of preference and damping greatly influences on the quality and the final number of clusters.


The university students in the age of social transformation are facing more and more pressures in their growth.This paper probes into the problem of that the university library,being as the culture and information center in the campus,should broaden its educational function,make full use of its own superiorities,and carry out the biblitherapy with different forms,different paths and different levels,and play an active role in mental health education for university students.


In this paper, the ballet of Igor Stravinsky The Rite of Spring is interpreted from the perspective of Gaston Bachelard's philosophical thought. Bachelard's systematic psychoanalysis of literary images in The Psychoanalysis of Fire is applied to the interpretation of musical images in The Rite of Spring. Bearing in mind that rhythm is a key characteristic of Stravinsky's composition, the paper analyses the immediate correspondences between Stravinsky's and Bachelard's perception and interpretation of rhythm in the works under consideration.


In this paper, a test system and equipment for determining the maximum experimental safe gap (MESG)of mineral firedamp is given .The separating explosion explosion external case of electrical equipment that is produced by this data an prevent the occurrence of firedamp explosion. The research results are very important for the production of coal mining in safety.


The invention relates to a time indication fluid infusion device with an infrared detection function. The time indication fluid infusion device comprises a drop bottle, an infrared sensor is installed at a drip tube of the drop bottle and connected with a host through an RF transmission module, and an output end of the host is respectively connected with a time displayer and a stopping and clamping device which is installed at an output tube of the drop bottle. The infrared sensor is adopted for the time indication fluid infusion device to detect injection fluid at the drip tube, the remaining injection time is displayed, the stopping and clamping device is wirelessly controlled through the host, artificial monitoring is not needed, and the time indication fluid infusion device has the advantages of being easy to operate and reliable in control.


The research seeks to portray the expansion of so-called cloud computing, cloud computing, additional element in business activities, that every day offers minimization of costs, upgrades to products, new warranties, contemporary technology infrastructure and support and product upgrades computer. In its execution sought to identify public companies that use the cloud computing services, likely to spread their activities, their processes, their services and even their management for this platform. Its raising indicate potential, severities, opportunities and reliabilities on the view of the executive managers. Especially in the public management, it describes the reflection of this platform in two cities – Curitiba and Porto Alegre – on these said strongest governments to modernity and inclusive participation in the practice of government. Describe this research effort in order to assemble a panel that helps to identify the direction for migration to the cloud is the promised alternative.


Background: Overexpression of CD123, the alpha subunit of the IL-3 receptor, is characteristic of a number of hematological malignancies, including acute myeloid leukemia (AML), thus providing an attractive candidate for targeted therapeutic approaches in this disease. IMGN632 is a CD123-targeting antibody-drug conjugate (ADC) comprising a novel anti-CD123 antibody coupled, via a peptide linker, to a unique DNA-alkylating payload of the recently developed IGN (indolinobenzodiazepine pseudodimer) class of cytotoxic compounds. Preclinically, IMGN632 exhibited potent antitumor tumor activity, with a wide therapeutic index, in models of AML. Confirming preclinical expectations, encouraging single-agent activity and manageable tolerability have emerged for IMGN632 in the ongoing Phase I trial in patients with CD123-positive AML (NCT03386513). Recently, preclinical data from AML mouse models were presented demonstrating synergy in combinations with azacitidine or venetoclax (EHA 2019), supporting the exploration of these combinations in this upcoming clinical trial.
 Study Design and Methods: This Phase 1b/2 study is designed to determine the safety, tolerability, and preliminary antileukemia activity of IMGN632 when administered in combination with azacitidine and/or venetoclax to patients with relapsed and frontline CD123-positive AML. Building on the encouraging activity observed in the Phase I study, the single-agent activity of IMGN632 in patients with minimal residual disease (MRD)-positive AML after frontline treatment will be assessed.
 Three combination regimens will be evaluated: Regimen A, IMGN632 plus azacitidine (632+AZA); Regimen B, IMGN632 plus venetoclax (632+VEN); and Regimen C, IMGN632 plus azacitidine and venetoclax (632+AZA+VEN). For each regimen, a Phase 1b dose escalation cohort (~24 patients) will determine the recommended Phase 2 dose (RP2D) of IMGN632 for the specific combination. This will be followed by a Phase 2 dose expansion stage to further characterize the safety profile and assess antileukemia activity of each combination (~35 patients/cohort). In addition, IMGN632 monotherapy will be explored in an expansion cohort of MRD-positive patients to assess conversion rate from MRD+ to MRD-.
 Adult patients with CD123-positive, relapsed or refractory AML, an Eastern Cooperative Group (ECOG) performance status ≤ 1, and who are deemed appropriate for experimental therapy, are eligible to enroll as part of the dose escalation phase. Key exclusion criteria for all regimens include prior treatment with HMAs for myelodysplastic syndrome, active central nervous system disease, or history of sinusoidal obstruction syndrome/venous occlusive disease of the liver. Escalation will follow a standard 3+3 design, with a starting dose for IMGN632 of 0.015 mg/kg administered intravenously on Day 7 of a 21- (632+VEN) or 28-day cycle (632+AZA, 632+AZA+VEN). In the MRD-positive cohort, frontline AML patients must be in complete remission (CR/CRi) for no more than 6 months and be MRD-positive, confirmed by central laboratory testing. IMGN632 monotherapy dosing in this cohort will be 0.045 mg/kg once every 3 weeks. The study is planned to open in October 2019.

 Daver: Hanmi Pharm Co., Ltd.: Research Funding; Otsuka: Consultancy; Otsuka: Consultancy; Incyte: Consultancy, Research Funding; NOHLA: Research Funding; Astellas: Consultancy; Novartis: Consultancy, Research Funding; Genentech: Consultancy, Research Funding; Novartis: Consultancy, Research Funding; Agios: Consultancy; BMS: Consultancy, Research Funding; Genentech: Consultancy, Research Funding; Forty-Seven: Consultancy; Jazz: Consultancy; Servier: Research Funding; Abbvie: Consultancy, Research Funding; Jazz: Consultancy; Sunesis: Consultancy, Research Funding; BMS: Consultancy, Research Funding; Immunogen: Consultancy, Research Funding; Abbvie: Consultancy, Research Funding; Glycomimetics: Research Funding; Hanmi Pharm Co., Ltd.: Research Funding; Karyopharm: Consultancy, Research Funding; Daiichi Sankyo: Consultancy, Research Funding; Astellas: Consultancy; Pfizer: Consultancy, Research Funding; Agios: Consultancy; Celgene: Consultancy; Incyte: Consultancy, Research Funding; Immunogen: Consultancy, Research Funding; Karyopharm: Consultancy, Research Funding; NOHLA: Research Funding; Pfizer: Consultancy, Research Funding; Servier: Research Funding; Glycomimetics: Research Funding; Daiichi Sankyo: Consultancy, Research Funding; Sunesis: Consultancy, Research Funding; Celgene: Consultancy; Forty-Seven: Consultancy. Erba:Agios: Consultancy, Speakers Bureau; Agios: Consultancy, Speakers Bureau; Celgene: Consultancy, Other: chair, AML Registry Scientific Steering Committee, Speakers Bureau; Pfizer: Consultancy; Seattle Genetics: Consultancy; Celgene: Consultancy, Other: chair, AML Registry Scientific Steering Committee, Speakers Bureau; Daiichi Sankyo: Consultancy, Research Funding; Novartis: Consultancy, Research Funding, Speakers Bureau; GlycoMimetics: Consultancy, Other: Chair, data and safety monitoring board, Research Funding; Daiichi Sankyo: Consultancy, Research Funding; GlycoMimetics: Consultancy, Other: Chair, data and safety monitoring board, Research Funding; Covance: Other: Fees for serving as chair on an independent review board for AbbVie Phase III studies; Covance: Other: Fees for serving as chair on an independent review board for AbbVie Phase III studies; AbbVie: Consultancy, Other: Chair, IRC for phase III studies, Research Funding; AbbVie: Consultancy, Other: Chair, IRC for phase III studies, Research Funding; Incyte: Consultancy, Speakers Bureau; MacroGenics: Consultancy, Other: Lecture fees, Research Funding; Incyte: Consultancy, Speakers Bureau; Astellas Pharma: Consultancy; Novartis: Consultancy, Research Funding, Speakers Bureau; MacroGenics: Consultancy, Other: Lecture fees, Research Funding; Jazz Pharmaceuticals: Consultancy, Speakers Bureau; Jazz Pharmaceuticals: Consultancy, Speakers Bureau; Amgen: Consultancy; Amgen: Consultancy; Astellas Pharma: Consultancy; ImmunoGen: Consultancy, Research Funding; ImmunoGen: Consultancy, Research Funding; Pfizer: Consultancy; Seattle Genetics: Consultancy. Papadantonakis:Agios: Consultancy, Honoraria. DeAngelo:Abbvie: Research Funding; Glycomimetics: Research Funding; Blueprint: Consultancy, Research Funding; Amgen, Autolus, Celgene, Forty-seven, Incyte, Jazzs, Pfizer, Shire, Takeda: Consultancy; Novartis: Consultancy, Research Funding. Wang:Amgen: Other: Advisory role; Agios: Other: Advisory role; celyad: Other: Advisory role; Pfizer: Other: Advisory role, Speakers Bureau; Stemline: Other: Advisory role, Speakers Bureau; Daiichi: Other: Advisory role; Abbvie: Other: Advisory role; Kite: Other: Advisory role; Jazz: Other: Advisory role; Astellas: Other: Advisory role, Speakers Bureau. Konopleva:Ascentage: Research Funding; Agios: Research Funding; Astra Zeneca: Research Funding; F. Hoffman La-Roche: Consultancy, Honoraria, Research Funding; Genentech: Honoraria, Research Funding; Ablynx: Research Funding; Calithera: Research Funding; Stemline Therapeutics: Consultancy, Honoraria, Research Funding; Forty-Seven: Consultancy, Honoraria; Eli Lilly: Research Funding; AbbVie: Consultancy, Honoraria, Research Funding; Cellectis: Research Funding; Amgen: Consultancy, Honoraria; Reata Pharmaceuticals: Equity Ownership, Patents & Royalties; Kisoji: Consultancy, Honoraria. Sloss:ImmunoGen: Employment. Wang:ImmunoGen Inc: Employment. Malcolm:ImmunoGen Inc: Employment. Zweidler-McKay:ImmunoGen: Employment. Kantarjian:Cyclacel: Research Funding; Jazz Pharma: Research Funding; BMS: Research Funding; Pfizer: Honoraria, Research Funding; Novartis: Research Funding; Astex: Research Funding; Actinium: Honoraria, Membership on an entity's Board of Directors or advisory committees; Daiichi-Sankyo: Research Funding; Ariad: Research Funding; Agios: Honoraria, Research Funding; Takeda: Honoraria; Amgen: Honoraria, Research Funding; AbbVie: Honoraria, Research Funding; Immunogen: Research Funding.