Research results on potato showed that the optimum N, P 2O 5 , and K 2O were about 104-150 kg ha -1 ,60-90 kg ha -1 ,and 150-210 kg ha -1 respectively. In balanced fertilization the VCR of fertilizer was over 7 and K fertilization was over 10. Net income increase by K fertilization was 4800 yuan ha -1 . The balanced fertilization could increase 1/2 or 1/3 potato yield in the areas and promoted potato quality as well.


This paper presents our findings from a research initiated to support teachers' continuous development through action research in the rural context of a developing country. The study investigated the experiences of seven teachers and teacher educators from the rural context of Pakistan, who spent nearly six months undertaking action research projects as part of a follow-up strategy for a universitybased teacher education programme. After the completion of the university-based programme, the participants had gone back to their respective institutes and were expected to initiate action research projects in order to implement new knowledge/learning. It was also a strategy to ensure the continuity of their professional growth. This study was designed to follow-up the participants' implementation of their action research plans in order to understand the processes involved in bringing reform in the teaching and learning situation in their context and identify related issues. The data includes pre and post conference discussion sessions with the participants as well as the observations of their classroom practice. The findings suggest that as part of their action research plans, and through the facilitators' support in the context, the participants were able to initiate change efforts and introduce innovative ideas in the classroom. The participants' engagement in this experience provided them with the opportunity and motivation to think about the actions that may improve their practice. However, going beyond the initial level of efforts in terms of being able to influence their teaching or teacher learning practices or to improve the learning experiences of students in classroom, were still difficult for them. Due to various constraints, the participants on their own were not able to understand and address the complex issues related to teaching or teacher learning. We conclude that action research in the rural context of a developing country can possibly be seen as a collaborative endeavor only. Various constraints restrict the possibility of engaging in action


Nano diamond is an important member in the nano material family.Because of its superior performances of both diamond and nano material,it has a widespread application field.The main target of recent use in superfine polishing,performance improvement of wear resistant coating and lubricating oil and PTFE provide a foundation for setting up nano diamond industry.The article also introduces nano diamond synthesis and its purification process and devices in Russia


Cristobalite SiO2 can be obtained from the fused silica ceramic waste of ploysilicon plant, due to the phase conversion of fused silica to cristobalite during the process of polysilicon ingot. Cristobalite powder materials with high purity are manufactured by milling the discarded waste above. Thermal expansion rate of the cristobalite and gypsum bonding moulds were studied, which show that the thermal expansion of the cristobalite phase transition could effectively compensate for the shrinkage of the gypsum at the temperature between 200 ℃ and 400 ℃. Casting experiments with copper alloy show that the cristobalite can improve the thermal performance of moulds for precise casting of jewelry.


Recently, robotic automation in clinical laboratory becomes of keen interest as a fusion of bio and robotic technology. In this paper, we present a new robotic platform for clinical tests suitable for small or medium sized laboratories using mobile robots. The mobile robot called Mobile Agent is designed as transfer system of blood samples, reagents, microplates, and any instruments. Also, the developed mobile agent can perform diverse tests simultaneously based on its cooperative and distributed ability. The driving circuits for the mobile agent are embedded in the robot, and each mobile agent communicates with other agents by using Bluetooth communication. The RFID system is used to recognize patient information. Also, the magnetic hall sensor is embedded to remove and compensate the cumulated error of locomotion at the bottom of mobile agent. The proposed mobile agent can be easily used for various applications because it is designed to be compatible with general software development tools. The Mobile agents are manufactured, and feasibility of the robot and localization of the agents using magnetic hall sensor are validated by preliminary experiments.


In P2P networks, trust mechanism in social networks can be used to build trust in peers for collaboration decisions. In this paper, as an initial step towards a definition of trust based access control framework, we focus on the relationship among components of the framework. We also exemplify how the trust based role assignment scheme can be designed in RBAC.


We estimate the economic impacts of irrigation using the panel data set from rural Thailand. We employed difference-in-differences estimation and showed that tertiary irrigation has unexpected impacts. Contrary to the local experts predicitions that it should have substantial productivity impacts as it allows better water controls for farmers, we found largely zero profitability impacts. Another unexpected finding is that, while profitability is not affected, we see an increase in cultivation probability with the construction of tertiary canals. This is observed in both wet and dry seasons. This finding suggests that Thai farmers are willing to expand operation scale once they get water.


This study examines the role of hedge and safe haven of four disruptive technology ETFs to six Asia emerging markets and assess whether if COVID-19 pandemic has altered the dynamic conditional correlations and hedge effectiveness between these assets. Using daily return data from February 23, 2018 to January 28, 2022, first, the results indicate that despite the outperformance of disruptive technology ETF's returns during COVID-19 pandemic, these ETFs do not have a hedge or safe haven property against Asia emerging market downturns as their returns were still positively correlated. They can only be used as diversifier tools to the Asia emerging markets. Second, the changes in the dynamic conditional correlations between the ETFs and Asia emerging markets were identified in which majority of the ETFs were found to have higher correlations with the emerging markets during COVID-19 period. This implies that the optimal hedge ratio or hedging cost between these assets were increased during the pandemic. Third, this study found that the disruptive technology ETFs can provide higher hedge effectiveness against Asia emerging markets during COVID-19 period than normal period due to shorting a unit of the ETF can reduce variance of the long-only portfolio in Asia emerging market by larger magnitude. Hence, these ETFs can be used as hedging tools to minimize the risk of Asia emerging market portfolio. This study provides insights for investors to formulate hedging strategies and determine portfolio diversification by thematic technology ETFs.


The objective of this project was to enable next-generation, efficient, easily manufacturable, and durable organic photovoltaics through interface and electrode engineering.


In applications where it is imperative that an event occur at a specified time but the data loading requirements cannot be met before the event trigger, like animation distributed over the Internet, it seems appropriate to send the most important data first so that the user at least receives the gist of the information before the application moves on. We offer a framework of graceful degradation of 3D character animation, such that the story narrative is maintained even if data transmission rates are erratic.


Heavy oil accounts for two-thirds of the world oil resources but contributes only one-seventh of the world oil production due to its high oil viscosity and heavy distillates. Steam injection has be...


Recently, historical and cultural inheritance of the region has become a problem in Japan. The purpose of this paper is to present the streetscape of post-town in Fujisawa on old Tokaido by detailed 3D models and game engine. In our previous studies, we have developed and evaluated urban space simulation system using the game engine. In previous studies, we have developed urban space simulation system using the game engine, the effectiveness of this system is tested through experiment. Based on this method, we reproduces the streetscape of the Edo Period in the system. It was possible to achieve the purpose of developed the system to inherit the memory of the region.


The objective of this report was to provide information to producers, policy makers, and other interested stakeholders on the both the agricultural producer perceived and data driven regulatory environment of Northeastern states. Notably the specific objectives were: Identify regulatory perceptions of Northeastern agricultural producers; quantify the regulatory environment via a data driven index computation; rank states within the Northeast as well as select comparable states throughout the United States; provide recommendations on the state level to lessen the regulatory burden for Northeastern states. Findings: Overall, agricultural producers in the Northeast indicated the number of regulations to be increasing since 2010. Furthermore, the amount of time and money spent on the regulations was also increasing. State regulations were found to have the most impact on producers changing their farming practices, followed by federal and to a lesser extent municipal regulations. Perceptions of regulatory impact are not always consistent with data driven indices. Several states ranking low on regulatory burden had a majority of agricultural producers perceiving there to be a high regulatory burden. In contrast, some states with a high burden had the perception of "just-right" or under-regulated. New Jersey was found to be the least regulated state while Maine and New Hampshire were the most regulated, according to this study's calculations. It is important to note that these rankings are relative to the other states in this study. On the whole, Northeastern states were more regulated than comparison states from around the United States. Of the sixteen states in the regulatory index, five of the bottom six were in the Northeast. Northeastern states, in general, moved around in how well they performed in the different policy components. Some states scored well in tax policy regulation but low in labor while others did well in labor but scored poorly in environmental. Thus individual components are important to consider with respect to regulatory impact. Using the results from the report it is clear that each state has areas where they can improve their regulatory burden on agricultural producers. Some states need to focus on lessening the burden of taxes while others may need to focus on labor or environmental policies. Furthermore, this report does find support for the anecdotal evidence that Northeastern states by and large have more regulatory burdens than comparable states throughout the United States.


System performance aspects of the Ku band radar communication hardware and investigations into the Ku band/payload interfaces are discussed. The communications track problem caused by the excessive signal dynamic range at the servo input was investigated. The management/handover logic is discussed and a simplified description of the transmitter enable logic function is presented. Output noise produced by a voltage-controlled oscillator chip used in the SPA return-link channel 3 mid-bit detector is discussed. The deployed assembly (DA) and EA-2 critical design review data are evaluated. Cross coupling effects on antenna servo stability were examined. A series of meetings on the acceptance test specification for the deployed assembly is summarized.


The main aim of this study is to use a carbon fiber composite board to replace the traditional graphite board. Because a carbon fiber composite has high mechanical strength and corrosion resistance and other desirable properties, we fabricate it into a current collector for use in a fuel cell. We use phenolic resin and flake graphite powder combined with carbon fiber plain weave to fabricate the carbon fiber composite current collector, which is carbonized in a high-temperature furnace at 800 °C. In this method, the resin, which has poor conductivity, is removed to increase the conductivity of the current collector. The electrical conductivity is measured using a four-point probe surface resistance machine and the flexural strength is measured using a universal material testing machine. In addition, the same characteristics of carbon fiber composite materials fabricated with different carbonization times are then discussed. Finally, the carbon fiber composite current collectors are assembled in single cells for performance testing.


The utility model discloses a mixed type armoring structure of a single-core high-pressure submarine cable, comprising a mixed armoring layer. The mixed armoring layer is annular and consists of green round copper wires and non-magnetism stainless steel wires, which are arranged at intervals. The mixed type armoring structure of the single-core high-pressure submarine cable has the following advantages: the submarine cable is armored by the mixed armoring layer consisting of the green round copper wires and the non-magnetism stainless steel wires, which are arranged at intervals, so that the armoring eddy current loss is reduced effectively, on the other hand, as the mixed armoring layer of the armoring structure is formed by arranging the green round copper wires and the non-magnetism stainless steel wires at intervals, the used green round copper wires are less, and compared with the double-layer flat green copper wire armoring layer, the cost of the armoring structure is greatly lowered, the whole mechanical performance of the submarine cable is improved, so that the performance of resisting severe environment is greatly improved; in addition, the armoring structure can be better applicable to the high-voltage submarine cable with 110kV and above.


Publisher Summary This chapter discusses organometallic complexes of fullerenes. The solid-state and organic chemistries of fullerenes are currently active areas of research with possible applications, for instance, in the field of superconductivity. The chapter describes the preparation, characterization, and properties of all nonpolymeric complexes that contain a metal σ- or π-bound to a fullerene. They readily react with many electron-rich metal centers to form stable π or σ complexes. Although the π complexes have not yet found any practical uses, they have proved helpful in structural characterization, as well as providing some insight into the dynamical behavior of fullerenes. The σ complexes are a relatively unexplored area, but where they have been prepared, they are useful intermediates in the preparation of organic fullerene adducts. As a result, fullerenes are more reactive than might be expected and behave like giant closed-cage alkenes rather than super arenes.


It has previously been shown that murine tissue derived T‐cells expressing the γδ T‐cell receptor can respond to autologous (stressed) cells implying the recognition of an autoantigen. Here we report that a large proportion of human synovial tissue and peripheral blood derived Vδ1+γδ T‐cell clones proliferate in response to stimulation with autologous and allogeneic EBV‐transformed B‐lymphobiastoid cell lines (LCL). In contrast, Vδ1‐γ/δ and α/β TCR+ T‐cell clones isolated from the same tissue samples did not display proliferation towards the LCL. The proliferative response of these Vδ1+ clones was dependent on contact between responder and stimulator cells and could be blocked by a MoAb to LFA‐1 and by antibodies to the γδ TCR/CD3 complex. Because the responses of these clones to LCL cells appear to be independent of the γ‐chain co‐expressed with the Vδ1‐chain these resemble a superantigen response. The capacity of this subset of Vδ1+ T‐cell clones to proliferate after stimulation with LCL may imply the recognition of an endogenous epitope. Moreover, since so far we have been able to isolate only LCL reactive γδ T‐cell clones from synovial tissue and peripheral blood of reactive arthritis patients and not from peripheral blood of healthy individuals, tbe frequency of such 'autoreactive'γδ cells may be higher in these patients.


The article describes the features of the system approach to forming the system of out-of-class and upbringing work at Kursk State Medical University. The analyses of its organizational levels is given, the substantial characteristics of the educational and upbringing space are described.


The two periodic soliton solution to the Davey-Stewartson II equation is analyzed to show that the periodic soliton resonance exists between them. There are two types of singular interactions: one is the resonant interaction that generates one periodic soliton after collision, while the other is the long-range interaction.


Provided is an image data generating device and a method thereof, and an image forming device and a method thereof. A data modification part (72) of an image forming device (1) delimits a block of figurative element set from the figurative element set of the image in an original pattern data, which is step 102. The profile of the delimited block of figurative element set is identified, which is step 105. Whether a long edge or a short edge is opposite to the profile of a figurative element which is located within the distance regulated by the identified profile is determined, which is step 106. Correction is calculated based on determination result, which is step 111. The data of the figurative element is modified, which is step 112.


Thanks to modern image generation techniques using deep learning, we can easily create images from simple sketches. Unfortunately, previous work focuses on generating a foreground only and does not consider composing the foreground and an arbitrary background image. Therefore, it suffers from unnaturalness arising from a composition between the generated foreground and the original background image. In this paper, we present a method that not only generates a foreground image from sketches but also composes the foreground and background naturally using a generative adversarial network (GAN). In particular, we propose three approaches to conditioning the GAN on sketches and a background. Evaluation experiments confirm that the proposed models obtain different results according to our design concepts and can synthesize more natural images than a baseline method.


In this paper,the results of the inversion model test are compared with that of the prototype observation of Gongboxia horizontal swirl discharge tunnel.Based on it,the characteristics of fluctuating pressure of this new type energy dissipater in the process of the gates' open-and-close were analyzed.The research results show that in both the prototype and the model,the pressure change with time is approximately consistent in the shaft upper ring-form aerators,in the spiral starter and horizontal swirl tunnel,and it accords with the gravity similarity principle.At the same time,due to the model scale effect,their cavity lengths of the ring-form aerators are different and the differences of pressure are also larger.Pressure changes on the wall of the spiral starter may be classified into four steps in the process of the gates' open.The dominant frequencies corresponding measuring points in the prototype and the model of horizontal swirl tunnel all belong to low frequencies,are far less than the inherent frequency of the building.


A method for detecting an voltage distribution among vacuum interrupters in series in a circuit breaker performing operation. It was shown that voltage distribution is dependent on the type and value of breaker output load. The method in question is shown to be instrumental for evaluation of the shunt capacitors used to achieve a more even voltage distribution among vacuum interrupters in series.


Abstract—The influence of mutual coupling among multiple input multiple output antenna (MIMO) systems is usually not negligible due to limited antenna spacing available in practice. A thorough understanding of such influence, however, is not available in the literature, although it is important to the design of a transmission strategy. In this paper, by formulating the equivalent channel matrix in terms of S-parameters that characterize mutual coupling, we obtain an explicit expression for the channel capacity. The maximization of the channel capacity so obtained leads to the optimal pre-coding strategy for the transmitter. Numerical examples are presented to illustrate the theory.


Design and fabrication of saturable Bragg reflectors (SBRs) by molecular beam epitaxy (MBE) is presented. Grown structures consisted of AlAs/GaAs quarter-wave layers with low-temperature InGaAs/GaAs quantum wells (LT QWs) as saturable absorber layers. Special emphasis is put on methodology of wavelength tailoring of distributed Bragg reflectors and on MBE technology of growing the quantum wells with the recombination time of excitons of the order of tens ps. Application of different methods of characterization of LT QWs and SBRs for testing and optimizing the MBE process is discussed.


The article will focus on the history of the formation of one of the fundamental branches of Kazakh literary science – Abay studies. An overview of the history of the formation and study of the history of Abay studies is made, scientific works that have shown the heritage of Abay in different years are analyzed. In the main part, a brief analysis of the history of Abai's knowledge, the study of the poet's heritage in general, a lot of scientifically valuable historical facts are analyzed. Through the work of scientists studying the history of Abay studies, the personality and civic identity of the poet are revealed. After studying the research of research scientists in research works and monographs, the importance and effectiveness of the modern discipline of Abay studies is shown. The history of the study and the stages of the formation of Abay studies are differentiated in modern times, when the degree of research of data on the heritage of Abay is increasing. Starting with M. Auezov, who brought Abay studies into the scientific system, based on the works of Y.Mustambayevich, K.Zhubanov, B.Kenzhebayev, K.Zhumaliyev, Z.Akhmetov, K.Mukhamedkhanov, M.Myrzakhmetuly, it is necessary to look at the history of the formation of Abay studies and analyze the works of the independence period from a new angle.


Now a day by the initiative taken by the Government of India in the scheme of "Smart India", all villages will soon transfer to Smart Villages. This will be achieved by the Information Technology Platforms. For converting the Villages to Smart Villages, the Internet of Things (IoT) plays a major Role in India. By using IoT everything in the village is connected to the Internet and it is controlled by the users anywhere by remotely. In our project we have taken the problems in Smart Garbage System and Smart Water Level Controller to distribute water from the common tank to all users. In Garbage System the wet and dry waste is identified separately and it regularly monitored whether the tank is full, then information given to municipality to clean that concern Garbage. In water level controller the utilization of water from common tank is controlled and managed by using the mobile application. Keep tracking of water level in the tank by float sensor and based on the water level it will be distributed to the users. The domestic public users also controlled by the user defined commands which is intercepted with the home of particular user.


Security in travelling is primary concern for everyone. Demand for automobile has increased traffic and thereby causing more accidents on the road. People lose their lives because of poor emergency facilities. Preemption of the accidents taking place on the roads is not possible but at least after effects can be reduced. Proposed system ensures, making emergency facilities available to accident victims as early as possible by letting people or hospital or rescue team or police station know the accident spot with the help of accelerometer embedded in the vehicle. As vehicle rolls over on the road thereby changing position of the accelerometer, message is sent to the first aid center, rescue team or police station using GSM. With the help of space navigation system GPS locates the position of the vehicle where accident has occurred. So, this paper deals with the GSM-GPS module and accelerometer and ATMEGA 16 microcontroller mounted vehicle, which even meet with the accident, let people know about the accident location and provides situational awareness. This project is about making cars more intelligent, they provide basic information covering geographical co- ordinates to the police station.


Today, children's health problems need new approaches. In this regard, the educational function of teachers and psychologists is important in order to form a child's idea of a healthy lifestyle, to form right attitudes to their's own health. This is of particular importance for young people, children, since they are the future generation that will continue our history, which has determined the relevance of this work related to the formation of a responsible attitude to a healthy lifestyle of children, which is the subject of this work. A psychological and pedagogical program for 4th grade students has been developed to form a responsible attitude to their health and healthy lifestyle. The implementation of the program includes three main levels: 1) Emotional involvement (emotional-value component of a responsible attitude); 2) semantic (cognitive component); activity (activity component). As a result of the implementation of the psychological and pedagogical program, the level of responsible attitude of children to their health has significantly increased. Namely, the number of children with a conscious attitude to their health has increased (cognitive component), the level of mastery of cultural norms has increased (emotional and value component), the number of schoolchildren participating in health-preserving and promoting a healthy lifestyle has increased


A consistent classical theory of atomic ionisation by charged particles is presented. The theory is consistent in the sense that not only individual collisions between the charged projectile and the atomic electron are described in a classical way (the theory is based on the binary-encounter approximation corrected for the collective field of the atom) but the entire atomic system considered as a classical structure with well defined electron orbits. The developed theory is applied to the analysis of atomic ionisation by heavy charged particles. The theoretical results appear to be sensitive to the atomic model used; in the case of the free-fall atomic model, they are found to be in good agreement with the experimental data.


The topicality is shown to improve the processing technology of complex polymetallic raw material containing a considerable amount of toxic impurities of arsenic and lead. Results on pressure leaching the mattes acquired after reduction smelting the dusts of OAO Sredneural'skii Copper Smeltery (SUMZ) by solutions of copper sulfate are discussed. These mattes contain a considerable amount of lead and arsenic. According to the data of X-ray phase analysis of matte samples, phases of sulfides (PbS, PbS·As2S3, Cu2S, FeS, and (Zn,Fe)S) and arsenides (FeAs2, Cu3As, FeAs, and Cu0,85As0,15), as well as inclusions of metallic copper, are revealed in them. Optimal parameters of matte leaching by copper sulfate solutions are the temperature of 150–180 °C, acidity from 5 to 30 g/dm3, and copper concentration of 14–32 g/dm3. This process made it possible to extract 85 % As into the solution, while copper and lead remained in the cake in this case.


Most existing buildings are not equipped with long-term monitoring system. For the structural model updating and damage detection of this type of structures, ambient vibration test is popular as artificial excitation is not required. This article presents in detail the full-scale ambient vibration test, operational modal analysis, and model updating of a tall building. To capture the dynamic properties of the target 20-story building with limited number of sensors, a 15-setup ambient vibration test was designed to cover at least three measurement points (each consists of a vertical and two orthogonal horizontal measured degrees of freedom) for each selected floor. The modal parameters of each setup were extracted from the measured acceleration signals using a frequency domain decomposition method and were combined to form the global mode shape through the least-squares method. Due to the regularity of the building, a simple class of shear building models was employed to capture the dynamic characteristics of the building under lateral vibration. The identified modal parameters of the building were employed for the model updating of the shear building model to identify the distribution of inter-story stiffness. Since the "amount" of the measured information is small when compared to the "amount" of required information for identifying the uncertain parameters, the model updating problem is unidentifiable. To handle this problem, the Markov chain Monte Carlo–based Bayesian model updating method is employed in this study. The identified modal parameters revealed interesting features about the dynamic properties of the building. The well-matched results between model-predicted and identified modal parameters show the validity of the shear building model in this case study. This study provides valuable experience in the area of structural model updating and structural health monitoring.


Recent research on the metaethical beliefs of ordinary people appears to show that they are metaethical pluralists that adopt different metaethical standards for different moral judgments. Yet the methods used to evaluate folk metaethical belief rely on the assumption that participants interpret what they are asked in metaethical terms. We argue that most participants do not interpret questions designed to elicit metaethical beliefs in metaethical terms, or at least not in the way researchers intend. As a result, existing methods are not reliable measures of metaethical belief. We end by discussing the implications of our account for the philosophical and practical implications of research on the psychology of metaethics.


I read with great interest the innovative technical article published recently in Journal of Thoracic and Cardiovascular Surgery by Lin et al . (1). The authors of the above mentioned article propose to access the pleural space in order to perform bullectomy/pleurodesis for primary spontaneous pneumothorax (PSP) through two small periareolar incisions with the patient in a semi-sitting position.


Generalized Honda formal groups are a new class of formal groups that in particular describes the formal groups over the ring of integers of local fields weakly ramified over Qp. It is the next class in the chain the multiplicative formal group — Lubin — Tate formal groups — Honda formal groups. Lubin — Tate formal groups are defined by distinguished endomorphisms [π]F , Honda formal groups possess distinguished omomorphisms that factor through [π]F and in the present paper we prove that for generalized Honda formal groups it is compositions of distinguished homomorphisms that factor through [π]F . As an application of this fact, some properties of πn-torsion points of generalized Honda formal groups are studied.


The invention relates to a walking and supporting dual-purpose device for a drilling machine. The walking and supporting dual-purpose device for the drilling machine comprises a base, an upper frame, a rotating oil cylinder, supporting oil cylinders and a moving oil cylinder. The walking and supporting dual-purpose device for the drilling machine is characterized in that the upper frame is provided with four supporting leg seats; four supporting oil cylinders are mounted in the four supporting leg seats in a movable disassembly manner respectively; the base is provided with four supporting seats; the tail ends of cylinder bodies of the supporting oil cylinders are provided with hinging heads; the supporting oil cylinders can be disassembled and overturned at an angle of 180 degrees; the hinging heads of the supporting oil cylinders which are overturned at the angle of 180 degrees can be connected onto the supporting seats in a hinging manner by using hinging shafts; the end of a piston rod can be upwards connected with the lower end of a supporting pipe assembly; the upper end of the supporting pipe assembly is used for mounting spherical joints and supporting disks; the supporting oil cylinders, the supporting pipe assembly, the spherical joints and the supporting disks are used in a combination manner, so as to form a hydraulic supporting mechanism. The walking and supporting dual-purpose device for the drilling machine is ingenious in structure and reasonable in design; not only can an underground drilling machine be enabled to walk conveniently when being moved, but also the underground drilling machine can be supported steadily when working; the labor intensity is reduced greatly; the work efficiency and the construction quality are improved.


The present invention relates to cellulosic fibers having a highly uniform cross section, in particular to a cross-sectional diameter coefficient of variation (CV (%)) of low cellulose fibers. In particular, the present invention relates to cellulosic fibers, wherein the coefficient of variation of cross-sectional diameter of the monofilaments constituting the multifilament (CV (%)) is less than 2.5, the multifilament cellulose powder is produced by dissolving in a liquid N- -N- methyl morpholine oxide (hereinafter referred to as NMMO) prepared in the. According to the present invention, a method for preparing lyocell multifilament comprising the steps of: (i) by the cellulose powder is uniformly dispersed, swollen and dissolved to prepare a spinning solution in NMMO solution; (ii) through the spinneret spinning the spinning solution into the air gap; and (iii) solidifying the extruded spinning solution through the spinning in the coagulation bath. In particular, so that the solidification step is carried out by adjusting the coagulation factor is adjusted to 0.8 to 1.3, and the coagulation factor is expressed as TD '/ TC, TD' = TD + TA-90, and TD, TA and TC represent temperature of spinning solution, temperature of the cooling air is applied in the gap, and the temperature of the coagulation bath.


To identify the key drivers of consumption, we analyzed consumer preferences and estimated the willingness to pay for craft beer compared with industrial products in Italy. For this purpose, we conducted an ad hoc survey of 469 craft beer drinkers and set up an econometric strategy using a machine learning estimation technique. The main results show that young consumers, the ability to perceive and evaluate quality, and the frequency of consumption are the main profile elements that, more than others, orient preferences. In the meantime, sustaining local beer producers, sharing good time with friends, and the perception of beer as healthier compared with other drinks are also important. The most preferable product attributes are can packaging and the search for unique taste.


An algorithm for reconstruction of the Earth's surface reflection coefficients from MODIS images is considered. The atmospheric correction of the data is carried out taking into account side illumination, additional light exposure of the Earth's surface to reflected radiation, influence of the inhomogeneous Earth's surface, and radiation polarization was carried out. To accelerate obtaining of results, it is suggested to use a number of approximation formulas and criteria. A comparison with the results of execution of the MOD09 algorithm for three regions of the Earth's surface (in Tomsk, Moscow, and Irkutsk Regions) demonstrated that in the first, third, and fourth MODIS channels, the average values of the data obtained by the proposed algorithm were closer to the reference ones than the results obtained by the MOD09 NASA algorithm; in the second MODIS channel, the difference reached an order of magnitude. In the eighth MODIS channel, one algorithm was preferable to another in some situations, whereas in other situations, wise versa.


The Spirit of Wine did not move between the Planes, with that nimbleness as Oil of Oranges, which gave me the Liberty to observe the Angles with more Deliberation.


A bs tr ac t  Education institutions are grappled with the issue of lacking interest of students in the study. Thus, this study was conducted to find out reasons for the lacking interest of students in the study. This was a quantitative research approach. The purposive sampling method was used as a judgement of the researcher to seek only low academic results students in order to furnish the research objectives. The scales were developed to measure the various concepts given in the form of hypothetic statements. The results show that the perceived teaching method was positively related to respondents' interest in the study. The low interest is further triggered by respondents'' lack of intrinsic commitment to study. This study concludes that interest was lacking due to both motives intrinsic as well as extrinsic. It is recommended that teachers' pedagogical skills need to be improved, and teaching should be made more interactive so that the real purpose of education can be served.


The classical model based predictive control leads to a variable switching frequency which could produce resonances in the input filter of the power converter, affecting the performance of the system. This paper proposes a fixed switching frequency model based predictive voltage control for UPS applications and a performance comparative between the proposed control and the variable switching frequency counterpart, showing the advantages and disadvantages among the two strategies.


By using the principles of transformer and taking into consideration of the operating characteristics of transformer,it is found after calculation and analysis that the 64 Standard transformer,after its iron core is replaced,its volume is reduced nearly a degree,but its operation loss at low load rate is lower than that of 86 standard transformer with the same volume.After studying the volume difference before and after the coil is replaced in the 73 Standard transformer,it is discovered with calculation that,though the copper for copper coil reform scheme reduces greatly the volume,its energy saving effect of operating under 1/4 low load is obvious,whereas the aluminium for copper reform can not only keep the volume unchanged,but also achieve good energy saving effect even when the agricultural transformer operates at low load rate.


In this paper, we consider an extension of some results to dynamic equations on discrete timescales originally due to Butler for second-order superlinear differential equations. As an application, we get that the superlinear difference equationis oscillatory, if .


Part I: Ophthalmic Pharmaceutical Procedures. Part II: Slit Lamp Biomicroscopy and Adjunct Procedures. Part III: Eyelid Procedures. Part IV: Lacrimal System Procedures. Part V: Conjunctival Procedures. Part VI: Corneal Procedures. Part VII: Ocular Microbiology and Cytology Procedures. Part VIII: Posterior Segment Procedures. Part IX: Physical Examination Procedures Part X: Cranial Nerve Examination. Part XI: Preoperative and Postoperative Cataract Procedures. Part XII: Glaucoma Evaluation and Treatment Procedures. Part XIII: Periocular Injection Procedures Part XIV: Ophthalmic Laser Procedures


In this paper, we propose an improved detail enhancement method via guided image. To achieve the best overall balance for the contradictory goals of edge-preserving smoothing and details capturing, we propose a method combining the guided image filter (GIF) with local detail enhancement and the weighted least squares (WLS) filter with global intensity shift for input image. To do so, we first make edge-preserving smoothing operators in the R, G, B channels respectively by the guided filter. We then utilize the former enhanced image as a model and execute global enhancement in the luminance channel. The important contents are well preserved without distorting the overall image structure which does not suffer from the gradient reversal artifacts in detail enhancement due to the abrupt change of the edge. This method can produce high-quality detail enhancement and edge-preserving smoothing. In addition, it produces halo-free edge-preserving smoothing because it distributes blurred edges globally. Experiments show that the improved guided filter is both effective and efficient in a great variety of computer vision and computer graphics applications, including edge-aware smoothing, detail enhancement, etc.


Method and system for processing a presbyopia, the first of the patient's eye is resected corneal surface of the first eye so that it can be seen at short through the central zone of the first eye, the patient a second eye related to resect the corneal surface of the second eye, as can be seen at short through peripheral zone of the first eye. A first eye of optical power is increased in the central zone, the second eye of the optical power increases in peripheral zone. In the first eye, it is used to see what the surrounding zone mainly far. In the second eye, the central zone is used to see what mainly far. The system includes a processor for directing the laser element to ablate the two eyes of the laser element and the patient.


Critics have been quick to point out the topographical connections between How It Is and Dante's Inferno, but none have fully explored the dynamics at work between Beckett's novel and its primary intertext. This essay argues that How It Is revisits the Inferno politically, in order to deconstruct the theological argument underpinning Dante's Christian epic. In this way Beckett operates not a "poetics of conversion" (Dante) but a "poetics of perversion".


The authors report 4 cases of partial uterine perforation by a copper-T IUD diagnosed by sonography. Symptoms included resistance encountered on attempted removal tearing of the strings and missing string. In all cases the IUD was inserted postpartum and all women were breastfeeding at the time of insertion. The most important sonographic findings that suggested partial uterine perforation were excentric localization of the device and partial visualization of the IUD in the myometrium. Improved methods of sonographic scanning are provided and the management of the problem is discussed. (authors modified) (summaries in SPA ENG)


In this paper corrosion kinetics was evaluated by Electrochemical Noise (EN) technique for carbon steel fasteners coated with nickel-cobalt (Ni-Co), immersed in synthetic seawater at 60°C and atmospheric pressure at Veracruz Harbor, Mexico. An electrochemical cell with a three electrode arrangement was used: two identical work electrodes and a reference electrode (saturated calomel electrode, SCE). An electrochemical study was performed to evaluate the applicability of this kind of materials in offshore submarine applications in the oil industry. In a general way, the smallest values of Vcorr were presented by the coated carbon steel. Potential and current transient analysis indicates that corrosion was dominated by a localized corrosion process. According to the obtained results, Ni-Co coatings provide both mechanical (by the hard coating of Ni-Co) and electrochemical protection and therefore can be used in a satisfactory way under submarine conditions.


The nlyte DCIM solution is built on industry standard technologies, such as the Microsoft® .NET framework, Windows® Server operating system and SQL Server® database, providing a robust, powerful and scalable architecture to fit the requirements of any organization. The user interface is built using powerful Adobe® Flex® to provide a rich interactive graphical interface that enhances the user experience and provides visual representation of relationships and concepts. Due to the intuitive design, users can be up and running with the system in less than one day.


Quantitative investment attempts to use computer algorithms to predict the price of securities and make automatic trading, in order to gain excess return on the stocks. This paper introduces a strategy based on machine learning algorithms and technical indicators. The model uses several popular technical indicators as inputs and predicts the movement of stock price after a certain short period. Then, a portfolio is constructed using the prediction result. The strategy buys the stocks whose returns exceed the predetermined threshold and sells (shorts) the stocks whose return are below the negative threshold. The empirical results show that the annual return is above 40%,which is far higher than the S&P500 index(2.14%). Considering the risk-adjusted return, the machine learning strategy is better than the S&P500 index. The Sharpe Ratio is higher than that of the S&P500.


Objective of the study – consider the symbolic coding of the physicality under the concept of an «orc» as a communicative practice of mass media during the Russo-Ukrainian War.

Methods of the study. In the process of the study, were used methods of systematization of open data sources, analysis, and interpretation. Due to the usage of the comparative-historical analysis, a transformation of the communicative tradition of usage of the «orc» lexem was discovered in mass media discourse from 2013 to 2022.

Results. The usage of the «orc» lexem in several contexts in mass media was studied: as a denomination of Russian militaries and citizens of the Russian Federation, which was established by the Ukrainian segment of media reality, and as a self-denomination of residents of the Russian Federation. The usage potential of this lexem under the communicative strategies of the information warfare was outlined.

The «orc» concept as a physicality tool in symbolic codes of the informational landscape was considered. The study determines in which was its prominent physical imagery in communication forms worldview filters of perception of the information.

The introduced concepts are evaluated. A custom view on the ethic relevance of the usage of the «orc» lexem in mass media is provided. Assumptions regarding the further perspective of this language practice are voiced out.

Novelty. Mass media remain the principal tool of representation of new meanings in the symbolic coding of the events that take place during the Russo-Ukrainian War. Messages that are fixed in this way have become the object of studying not only in scientific investigations of social communications, but also of linguistics and media psychology. The analysis of popularity of the «orc» concept in mass media and meme culture in Ukrainian journalism studies has received single episodes of attention. Apart from this, separate research works contained value judgement of the ethic problems of this communicative practice, which fact narrows down the understanding of its cultural phenomenon.

Practical significance. The results of this research can be used in the studies dedicated to media awareness, hate speech in mass media and memes (the approach that researches functionality of memes as entities of cultural information). also, the study may be interesting to practical journalists as a means of studying the impact of emotional-imaginative content on their audience.

Key words: full-scale war, Russo-Ukrainian War, orcs, mass media, mass media means, media reality, image of the enemy, physicality, meme, visual image.


This article analysis the environmental effects produced by supplying and using common petroleum energy,and consider that raising the energy coefficient of utilization should be the frist choice for energy policy in our country,and how to develop and use renewable resources is also a widely energy conservation.


This report examines water quality, levels, and use for groundwater in the Eureka Area, Humboldt County, California. It includes maps, graphs, and other figures.


The present investigation entitled "Studies on physico-chemical changes of aonla (Emblica officinalis Gaertn) cvs. during growth and development under Chhattisgarh region" was carried out during rainy-winter season of 2002-03 at Research Farm, Department of Horticulture, Indira Gandhi Agricultural University, Raipur (C.G.). The experiment was laid out in randomized block design with eight varieties namely Banarasi, Chakaiya, Francis, Kanchan, Krishna, NA-6, NA7 and NA-10 and three replications. Results revealed that Banarasi maintained uniformly higher average fruit weight, length, total soluble solids, acidity and ascorbic acid. The pattern of growth of average fruit volume and stone weight was almost same as in case of growth of average fruit weight. Hence, it was highest in Krishna. The cultivar NA-7 had continuous increase in diameter up to 130 days and mentioned highest. The average highest moisture per cent was found in cv. Chakaiya at harvest maturity and total sugar was obtained highest in Krishna. Dept. of Horticulture College of Agriculture Raipur (C.G.) Date: Ol.(0-5003 Dr. Prabhakar Singh (Major Advisor)


Ethnographic writing that exchanges narrative and exploration for the exposition of theoretical findings is ultimately a way for ethnographers to maintain power over the uninitiated and even over their participants. This style also serves to distort the unique forms of knowledge that ethnography can provide. The stronger, more intimate writing styles of literary journalists allow more interpretive space for more readers. However, ethnographers must choose those readers directly: It is unlikely that ethnographers will be able to write for both colleagues and the public simultaneously, as they have entirely different criteria for successful writing. This article compares a traditional and a literary ethnography, expands on the above argument on audience, and closes with an example of the author's work that is aimed explicitly at a general audience.


In this paper, we proposed a novel Burst Drop Policy based on Hop Number Factor (HNF) in the core nodes of TCP over OBS networks, which is combined with Multiple Thresholds in the edge nodes. The proposed drop policy, HNF, takes the retransmission cost into account, and gives the burst with the larger Hop Number Factor the higher priority in the contention. On the other hand, for the retransmission is not always effective, multiple Edge Thresholds, Retransmission Number Threshold (RNT), Traffic load Threshold (TlT) and Total hop Threshold (ThT), are proposed to limit the unnecessary retransmission in the OBS layer. If any of the thresholds is exceeded, the retransmission will be handed over to the upper layer, the TCP layer, which will be more cost-effective. The simulation results show that the combined mechanism can reduce the burst loss rate, decrease the round trip time and improve the throughput of TCP over OBS networks significantly.


Objective To observe the clinical efficacy of "Qizhong Ganule" in the prevention of influenza.Methods Ninety people liable to influenza were prevented by "Qizhong Granule" for three days.The clinical symptom scores were observed before and after treatment.Result After treatment,the clinical symptoms were relived and their scores were reduced(P0.01);the total effective rate was 95.7%.Conclusion: "Qizhong Granule" is effective to prevent influenza.


Sonic booms at levels typical for supersonic airlines (<3 psf) are considered harmless to hearing based on laboratory studies. However, data on laboratory animals are difficult to generalize to other species. Wildlife present a particular problem because experimental efforts to induce permanent threshold shift (PTS) cannot be conducted for ethical or management reasons. Instead, ''significant'' temporary threshold shift (TTS) has been proposed as a conservative damage risk criterion (DRC). With this in mind, two series of experiments were conducted using simulated N waves at levels up to 6 psf, rise time down to 0.4 ms, and 100‐ or 300‐ms duration—one on seals and sea lions and a second on the desert tortoise. Level of the least‐detectable auditory brainstem response (ABR) was used to estimate best sensitivity before and after exposure. Small immediate threshold shifts (∼5 dB) were detected in pinnipeds and larger (∼20 dB) shifts in desert tortoises. The greater impact on desert tortoises may be explained by their greater best sensitivity at low frequencies. No PTS was detected. Thresholds for TTS were therefore detected in both species and may be useful in establishing DRCs for animals. [Work supported by NASA, Contract No. NAS1‐20101 and USAF, Contract No. F33615‐89‐D‐4003.]


Sequencing the genes encoding the methyl viologen-reducing hydrogenase, cloned from Methanobacte-num thermoautotrophicum strain AH and Methanothermus fervidus, revealed the presence of tightly linked genes, designated mvhB, which were predicted to encode proteins containing six tandemly arranged bacterial ferredoxin-like domains. A lacZ-mvhB gene fusion has been constructed and expressed in Escherichia coli. Rabbit antibodies raised against the fusion polypeptide purified fromE. coli have been used to identify and isolate the polyferredoxin from Mb. thermoautotrophicum strain AH. The polyferredoxin accumulates in cells of the methanogen during exponential growth but decreases rapidly on entry into stationary phase. It is not processed into monoferredoxins and is located primarily in the soluble fraction of cell lysates ofMb. thermoautotrophicum. Metronidazole reduction by crude extracts of Mb. thermoautotrophicum strain AH cells, dependent on the presence of hydrogen and the heterodisulfide CoM-S-S-HTP [formed from the two coenzymes 2-mercaptoethanesulfonic acid (coenzyme M, HS-CoM) and N-(7-mercaptoheptanoyl)threonine 03-phosphate (HS-HTP)J, was not inhibited by the antibodies raised against the LacZ-MvhB fusion polypeptide.


High quality placement results are always produced at the cost of significant runtimes. In this paper, we study the trade-off between the overall quality and the runtime for standard-cell placement problems. We implemented and studied a class of schemes to achieve the runtime vs. quality trade-off. We developed a new trade-off oriented placement tool (TOOP) which is controlled by decision trees. TOOP can adjust itself based on user's requests and netlist properties. Compared to Cadence QPlace, even the fastest mode of TOOP (lowest quality) can produce placements with similar or better layout. TOOP also shows much stronger ability to produce routable placement when compared to Capo.


Pleuramesothelioma is malignant tumor on the pleura, caused by asbestos exposure. Computer-assisted diagnosis system shall support physicians to assess the growth rate of detected pleural thickenings from CT data. This paper describes a new, improved method to automatically assess the size of detected thickening using thin plate spline interpolation which then leads to the 3D modeling of thickening. First, we detect each pleural thickening. Second, an automatic coordinate transformation is applied to enable the numeric calculation of the spline. Next, the appropriate landmark points are then automatically selected by using the newly applied chain-code concavity analysis and used as the constraint points for the interpolation. Numerical integration is applied to calculate area by slice. In the final step, the spline interpolation between layers is applied to calculate volume of each thickening. The results show that the thin plate spline interpolated boundary is suitable for 3D modeling of the thickening.


An E0-semigroup α = {αt : t ≥ 0} acting on B(H) is called pure if its tail von Neumann algebra is trivial in the sense that ∩tαt(B(H)) = C1. We determine all pure E0-semigroups which have a weakly continuous invariant state ω and which are minimal in an appropriate sense. In such cases the dynamics of the state space must stabilize as follows: for every normal state ρ of B(H) there is convergence to equilibrium in the trace norm lim t→∞ ‖ρ ◦ αt − ω‖ = 0. A normal state ω with this property is called an absorbing state for α. Such E0-semigroups must be cocycle perturbations of CAR/CCR flows, and we develop systematic methods for constructing those perturbations which have absorbing states with prescribed finite eigenvalue lists. 1991 Mathematics Subject Classification. Primary 46L40; Secondary 81E05.


The high-order harmonic generation (HHG) from aligned CO2 molecules is investigated as a function of aligning laser intensity. Through controlling the molecular field-free alignment by varying the aligning laser intensity, the HHG process can be controlled. This phenomenon can be attributed to that the molecular HHG is dependent on the angle between the laser polarization and the internuclear axis, and the theoretical simulation is detailedly presented, which is consistent with the experimental result. This investigation is useful for the efficient harmonic generation from aligned molecules.


The applications of traditional retroviral vectors are limited because proviral integrations into the host genome require DNA synthesis. Lentiviruses are considered to be advantageous because of their ability to infect non‐dividing cells.


MOTIVATION
A common problem with electrophysiological recording is the contamination of the signal of interest with interference generated at mains frequency. Standard filtering techniques are often inappropriate because the signal of interest has components spectrally close to the mains frequency.

RESULTS
A digital subtraction method is described for removing mains frequency interference from pre-recorded data. The data are first digitized with a sample rate that is some direct multiple of mains frequency. Next a 20 ms (for UK mains frequency) data set is constructed containing the average interference pattern. This is subtracted from each 20 ms window of the raw data. Finally, the mean value of the interference is added back to the raw data to restore the DC component.

AVAILABILITY
A Windows program which implements the method for the EGAA data acquisition system (R.C.Electronics, Santa Barbara, CA) is available from the author.

CONTACT
firstname.lastname@example.com


Background: Mountain settings are characterised by limited access to reproductive, maternal and child health services. The scope of health research in these communities limits understanding of contextual needs that are critical in the implementation of effective health programmes. Aims: To establish the family planning needs among couples residing on the slopes of the Rwenzori Mountains in Kasese District, western Uganda. Methods: A cross-sectional, interviewer-administered questionnaire surveyed 400 couples in the mountainous sub-counties of Kilembe and Mahango between June and July 2015. Simple descriptive statistics were used to describe participants' family planning needs. Findings: The majority of the participants (66%) were female. On average every couple had 5 children and 35.5% wanted no additional children. While all participants knew of at least one method of contraception, 32.5% did not know where to obtain family planning services. Use of contraception was 16.3%. Only 2 in 10 individuals who r...


Based on Delta operator,in which the sampling period is an explicit variable,a unified design method of non-fragile guaranteed-cost speed controller for permanent magnet linear synchronous motor(PMLSM) under different sampling period is studied.The condition of existence of the controller is given in LMI form.In the pole analysis of the PMLSM,we find that even if the parameters of the PMLSM and the controller are subject to additive norm-bounded variations,the closed-loop system is still asymptotically stable,and the upper bound of the mathematical expectation of the cost function can be obtained as well.However,the closed-loop system will be unstable if the controller gain variations are not considered.


The dry dual clutch of a passenger car is taken as the research object, and its three-dimensional model is established by software CATIA. On this basis, the thermal load characteristics of the dry dual clutch under the condition of multiple starting on the ramp are analyzed by software ABAQUS. The analysis results show that the temperature rise and thermal stress of the parts caused by the friction heat are within the normal range, which indicates that the designs of the pressure plate and the intermediate driving plate meet the requirements. This study obtains the distributions of the transient temperature field of the clutch friction pair under the conditions of the multiple starting, which has an important reference value for the design and optimization of the dry dual clutch.


It is important for the agroecological conditions of soils to evaluate the influence of cultivation on the level of phytotoxity of soils. The differentiation of arable layer under the minimization of tillage due to the content of humus, of elements of mineral feeding is determined. The intensification of processes of transformation post-harvesting residues reduces the toxity of arable layer. The dutente of microbiological activity by minimization of soil tillage provokes the growing of phytotoxity


A nationwide survey was conducted to identify how well people understand pedestrian safety issues. The study focused on the respondents' assessment of pedestrian involvement in traffic accidents and knowledge of pedestrian-related traffic control devices and pedestrian-related laws. Responses from both pedestrians and motorists were included in the findings. Questionnaires were distributed at driver's license examination stations in each of the 48 contiguous United States. The American Association of Retired Persons (AARP) also distributed questionnaires to many of its members participating in a defensive driving course offered by the organization. From the examination stations, 3,595 completed questionnaires were returned, while 1,231 completed questionnaires were returned from the AARP. The surveys were disaggregated based on the personal experience and demographic characteristics of the respondents. These groups were tested using the chi-square method to identify statistically significant differences. The study found that a high percentage of the respondents are knowledgeable of proper pedestrian-vehicle interaction. Many of the respondents, however, appear to have a poor understanding of many of the pedestrian-related traffic control devices and issues related to safe pedestrian habits. While many of the disaggregated groups showed statistical differences, few showed practical differences that would justify the development of special programs to target specific groups, such as the elderly.


Hydrogen, methane, methanol, and electricity are compared as potential future energy carriers supplying energy for two applications--space conditioning and automobiles. Several methods of employing each energy carrier in each application are investigated. The comparison is based primarily on the net efficiency of energy use and the operating costs (for energy) for each method of utilization which are computed for technology anticipated to be available in the year 2000. Electricity is found to provide the most efficient overall utilization of energy in virtually all cases considered.


Starting from the concept of "fille 'e anima" (soul child) and the analysis of the various foster care practices derived from the tradition and custom of Roman law, the first part of the article deals with the evolution of foster care in Sardinia's Medieval and Modern Age history. The second part of the study focuses on highlighting how this practice has been a source of inspiration in literature not only in Sardinia but throughout Italy, with analysis of the protagonists in three famous novels: Grazia Deledda's Edera, Michela Murgia's Accabadora and Sebastiano Vassalli's Chimera.


Objective Trying to find the ways to enhance the expression of cyp71av1 gene encoding cytochrome P450 mono-oxygenase which is a key enzyme in artemisinin biosynthesis pathway accelerating the artemisinin synthesis,the promoter of cyp71av1 was isolated and characterized.Methods 5' untranslated regions of cyp71av1 were isolated from Artemisia annua with thermal asymmetric interlaced PCR.For functional characterization,the isolated fragments were fused with β-glucuronidase GUS reporter gene and introduced into Nicotiana tabacum by Agrobacterium-mediated transformation.The GUS expression regulated by 5' untranslated regions of cyp71av1 in transgenic N.tabacum under the normal or stressed conditions were detected by histochemical staining and quantitative spectrophotometry assay.Results Two DNA fragments upstream of cyp71av1 coding sequence,a long fragment and a truncated fragment,were isolated from A.annua and introduced into N.tabacum respectively.Histochemical staining showed that two isolated fragments confered stable GUS expression in transgenic plants,and no significant difference was found between the two fragments on the GUS activity.The quantitative results also showed that the GUS activity in transgenic tobacco plants treated by dehydration,low-temperature(4 ℃),and ultraviolet irradiation were 1.4 to 2.7 folds higher than that in the controls.Conclusion It suggests that the isolated fragments has promoter activity and may be responsive to adverse environmental stresses.


The present invention is a copolymer acid, at least one amino acid compound, and cation of α- olefin and unsaturated carboxylic acids, - relates to a low molecular weight ionomer salt of a copolymer reaction product of the containing material. Unsaturated carboxylic acid is preferably α, β- ethylenically unsaturated carboxylic acid. The invention includes a method for making the ionomer. The ionomer has a different polymer, in particular a polyamide with excellent screen synthesis. Ionomers are useful in a method of treatment of the flushing water from the pigment.


A bstract: W e study the di(cid:11) ractive electroproduction of quarkonia from quark-antiquark-gluon statesin thephoton wavefunction.W eshow thatthesestates contribute to the leading-power and leading-logarithm level. W e suggest the m ea-surem entof J= production via inelastic di(cid:11) raction to study color-transparency and color-opacity e(cid:11) ectsin the di(cid:11) ractive gluon distribution. K eyw ords: Q CD ,D eep Inelastic Scattering.


Users often can see from overview-level statistics that some results look "off", but are rarely able to characterize even the type of error. Reptile is an iterative human-in-the-loop explanation and cleaning system for errors in hierarchical data. Users specify an anomalous distributive aggregation result (a complaint), and Reptile recommends drill-down operations to help the user "zoom-in" on the underlying errors. Unlike prior explanation systems that intervene on raw records, Reptile intervenes by learning a group's expected statistics, and ranks drill-down sub-groups by how much the intervention fixes the complaint. This group-level formulation supports a wide range of error types (missing, duplicates, value errors) and uniquely leverages the distributive properties of the user complaint. Further, the learning-based intervention lets users provide domain expertise that Reptile learns from. In each drill-down iteration, Reptile must train a large number of predictive models. We thus extend factorized learning from count-join queries to aggregation-join queries, and develop a suite of optimizations that leverage the data's hierarchical structure. These optimizations reduce runtimes by >6× compared to a Lapack-based implementation. When applied to real-world Covid-19 and African farmer survey data, Reptile correctly identifies 21/30 (vs 2 using existing explanation approaches) and 20/22 errors. Reptile has been deployed in Ethiopia and Zambia, and used to clean nation-wide farmer survey data; the clean data has been used to design national drought insurance policies.


An experiment was under taken in rainy seasons of 2015 and 2016 to estimate the gene action involved in inheritance of resistance to Yellow Vein Mosaic Virus (YVMV) disease in okra (Abelmoschus esculentus (L.) Moench). Thirty okra advance lines were screened against the natural incidence of YVMV disease in northern Indian condition during rainy season of year 2015, which is the most congenial season for population build-up of whiteflies (Bemicia tabaci), the vector of YVMV. Two resistant (HBT-12 & HB-1157) and two susceptible (HBT-49 & HBT-24) lines were identified and crossed in resistant × susceptible fashion to obtain four hybrids and their advanced generations, viz. first and second filial generations (F1 and F2) and backcrosses (BC1 and BC2) to study their segregation pattern for YVMV resistance and to record the days to first appearance of YVMV disease in various generations of the crosses, thereby to reveal the gene action involved in these resistant lines. Qualitative analysis for YVMV resistance through segregation in the F2s and backcrosses of four cross combinations revealed the involvement of two complementary dominant genes in HBT-12 and a single dominant gene in HB-1157, while involvement of additive gene action in all these crosses was revealed by quantitative analysis performed for disease related trait, days to first disease appearance via generation mean analysis.


We sought to determine whether lifestyle modifications are associated with high‐density lipoprotein cholesterol (HDL‐C) change in a cohort with long‐term follow‐up.


OBJECTIVE:To observe the near-future efficacy of amifostine on patients with head and neck squamous cell carcinomas undergoing hyper-fractionated radiation therapy combined with chemotherapy of cisplatin,docetaxel and5-fluo-rouracil(5-FU)and to evaluate its hematologic toxicity.METHODS:37patients with head and neck squamous cell carci-nomas were randomized to two groups:control group undergoing hyperfractionated radiation in combination with the chemotherapy of cisplatin,docetaxel and5-FU regimen,and protection group undergoing the additional amifostine injec-tion on the basis of same regimen with that in control group.The near-future efficacy,acute and chronic radiation damage as well as hematologic toxicity were observed in both groups.RESULTS:The effective rates in protection and control group were44%and39%(P=0.683),respectively.The acute and chronic radiation damage were found to be significantly lighter,the minimum white blood cell counts higher,and the occurrence of peripheral blood toxicity atⅡdegree or greater was lower in protection group,as compared with those in control group.CONCLUSIONS:Amifostine has no significant effect on the near-future efficacy of hyperfractionated radiation in combination with the chemotherapy in treating head and neck squamous cell carcinomas,but it can reduce the acute and late radiation damage and plays a role in protecting bone marrow.


The inability of acoustic holograms to independently modulate both phase and amplitude of incident waves is circumvented by multiple phase holograms designed using an iterative Fourier transform algorithm.The inability of acoustic holograms to independently modulate both phase and amplitude of incident waves is circumvented by multiple phase holograms designed using an iterative Fourier transform algorithm.


The abstract should be self-contained and citation-free and should not exceed 250 words. Abstracts of randomized controlled trials (RCTs) should consist of six paragraphs, labeled Background, Objective, Design, setting, participants and interventions, Main outcome measures, Results, and Conclusion. Abstracts of original experimental research papers should consist of four paragraphs, labeled Objective, Methods, Results and Conclusion.


XLA is an X-linked immunodeficient disease in man resulted from mutations in the BTK gene. BTK contains a unique amino-region of unknown function, SH2 and SH3 (src homology) domains, and a carboxyl-terminal kinase (SH1) domain. We have studied the normal genomic organizations of the SH2 and SH3 domains and found the regions containing 6 exons are about 3000 bp in length. We also carried out sequence analyses of cDNA and genomic DNA of XLA patients to identify mutations. Four of fourteen families with XLA were found to have mutations within the regions. (1) A point mutation G to T in codon 240 resulted in a stop codon. (2) A transition mutation (g to a) at first nucleotide of intron 8 resulted in exon 8 skipping, missing 21 codons and shorter polypeptide but with normal kinase activity and ATP binding ability. (3) An a to t transversion at one of the invariant dinucleotides (ag) of the 3{prime} end of intron 11 resulted in alternative splicing at a position 13 nucleotides downstream from the normal one. The mutation produced mRNA with 13 nucleotide deletion and presumably resulted in a frameshift at codon 372 leading to a stop codon at 398. (4) Amore » 16 nucleotide duplication (1248 to 1263 of the cDNA sequence) consistently present in mRNA of three brothers with XLA. However, genomic sequence of patient DNA of the regions did not reveal the anormaly. The observation that mutations within SH2 and SH3 causing severe B-cell defects typical for XLA suggests that these two domains are crucial for the function of BTK, possibly by regulating the interaction of cytoplasmic proteins involved in signal transduction.« less


As a very important assistant treatment for the life-saving,mechanical ventilation plays a vital role in creating condition and striving for time in the therapy process of the primary affection.Once the underlying cause of respiratory failure has either improved or been resolved,and an adequate capacity of breathing spontaneously is achieved,it is reasonable in time to wean the patients from mechanical ventilation in order to avoid the dependence on mechanical ventilation and reduce the complications associated with ventilator.But traditional weaning by doctor′s experience could prolong the time of mechanical ventrilation,increase complications and cost of intensive care,which protocol-directed weaning could reduce.This review is focused on the weaning and its techniques.


The invention relates to a perforation of a well treatment method, in particular by intervention to the cable, in order to seal or strengthen them. This process essentially comprises the following successive steps: (a) providing, near the perforation to be treated, a dehydration powder chamber (32) producing a large volume of gas at high pressure and at elevated temperature, as well as composite powder chamber (40) for processing the perforation (b) is set on fire to dehydration powder; (C) once the combustion completion dehydration powder, ignited in the composite powder so that treatment of the perforation can occur. The invention also relates to a device for carrying out this process.


Why study the gentrification of Asian American communities? Since 2010, the Asian American population in New York City has increased by 345,000 and now makes up 15.6 percent of the entire city population.[i] Despite this, there is little research on how this community interacts with the larger city society. While New York City is often cited as an example of gentrification, those research projects tend to explore the displacement of black and Hispanic people, rather than Asian Americans. It is pertinent to not place the movement of Asian Americans under the same umbrella because of the unique challenges that they face — most critically, the language barrier and the concept of being a "model minority".


Introduction. Imatinib has revolutionised the treatment of chronic phase-chronic myeloid leukemia (CP-CML), with up to 70% of patients (pts) achieving major molecular response (MMR, BCR-ABL1 < 0.1% IS). Achievement of MMR by 2 years (yrs) is associated with an excellent prospect of long term survival. Currently, three baseline prognostic scoring systems - the Sokal, Hasford (Euro) and EUTOS risk scores - have all been used to identify pts with a poor response and/or an adverse prognosis in CP-CML. Recently, the EUTOS long-term survival (ELTS) score is shown to have strong predictive power for overall survival in CML pts. We have previously reported bioassays that have significant value for predicting MMR. Combinations of these biomarkers, together with clinical risk score, may provide a better indicator of high risk pts at the time of diagnosis.
 Aim. To identify high-risk pts by combining selected predictive bioassay, determine whether the ELTS score is more discriminating, and determine whether it provides additional predictive value when combined with the biomarker score.
 Methods. Bioassays including CRKL IC50 imatinib (White, Blood, 2005), OCT-1 Activity (OA)(White, JCO, 2010), leves of 39 plasma cytokines (Nievergall, Leukemia, 2016), expression of 20 most prognostic gene by qPCR TLDA (Kok, ASH abstract, 2015), ABCB1 gene expression (Eadie, Leukemia, 2016), KIR2DL5B genotype (Yeung, Blood, 2015), BIM and ASXL1 polymorphisms (Marum, Blood advances, 2017) were used in this study. High-risk by biomarker score (HR) was defined as pts who did not achieve MMR by 2 yrs. 210 TIDEL-II pts (frontline imatinib with early switch to nilotinib for failure to meet optimal time-dependent molecular targets) were used in this study (Yeung, Blood, 2015). Only 201 pts had ELTS scores. The Recursive Partitioning and Regression Trees (rpart) algorithm was used to identify important bioassays in predicting high-risk pts. Fisher's-exact test was used for statistical analysis.
 Results. In the TIDEL-II cohort, there were 21 high ELTS and 180 low/intermediate ELTS pts. Pts with high ELTS had significantly lower rates of MMR by 2 yrs compared to those pts with low/intermediate ELTS (57% vs 81%, p=0.02). We constructed a predictive model using multiple different bioassays as variables to predict high-risk pts. The rpart based model used in this analysis yielded four variables (IGFBP2 gene expression, KIR2DL5B genotype, OA, and MCP-1 cytokine plasma level) as most important for predicting high-risk pts. The accuracy of the model was 84%. Pts predicted as high-risk (HR, n=27) had significantly lower MMR achievement rate compared to those predicted as low-risk (LR), (26% vs 86%, n=183, p<0.0001, OR:17.3). Importantly, pts with HR had significantly higher rate of blast-crisis progression (15%, n=4/27) compared to those with LR (1.6%, n=3/183, p=0.006, OR:10.4) and pts with high ELTS (5%, n=1/21). Interestingly, there were two categories of HR patient groups based on the model: 1) Patient with high IGFBP2 gene expression and low OA, and 2) pts with low IGFBP2, KIR2DL5B positive genotype and high MCP-1 cytokine level. When combined with ELTS, the bioassays model improved ELTS performance in predicting HR pts. For instance, within the low/intermediate ELTS pts group, our assays could futher distinguish HR pts with inferior MMR (n=20, 2 yrs MMR of 30%) versus LR pts (n=160, 2 yrs MMR 87%). Similarly, pts with high ELTS in combination with HR also had lower MMR rate (n=1/5, 20%) compared to pts with high ELTS in combination with LR (n=11/16, 69%, p=0.11, OR:8.8).
 Conclusion. We developed a combined bioassays model that is predictive of MMR failure and adverse clinical outcomes for pts who receive optimised frontline imatinib therapy. This model performs well even without adding clinical parameters. Our model has additional predictive value when used together with the ELTS score, and can distinuguish HR pts within the low/intermediate ELTS group, as well as LR patients within the high ELTS category. Further confirmation of the predictive performance of this model, using a large independent patient cohort is now indicated. We postulate that this bioassay-based model could be used, in combination with ELTS, for identifying HR pts who would benefit from intensified therapeutic approaches to obtain optimal clinical outcome.

 Yeung: Amgen: Honoraria; Pfizer: Honoraria; BMS: Honoraria, Research Funding; Novartis: Honoraria, Research Funding; Specialised Therapeutics Australia: Honoraria. Yong:Celgene: Research Funding; Novartis: Honoraria, Research Funding; BMS: Honoraria, Research Funding. White:BMS: Research Funding; Novartis: Honoraria, Research Funding. Hughes:Novartis: Honoraria, Membership on an entity's Board of Directors or advisory committees; Incyte: Honoraria, Membership on an entity's Board of Directors or advisory committees; BMS: Honoraria, Membership on an entity's Board of Directors or advisory committees.


The booms and crises of the economy are subject to certain rules, seen by economists issuing tens and even hundreds of years ago. These rules also affect the development of innovation in society, creating new forms of management fo technological processes and innovation companies. Unfortunately the financial technology develops much slower than technology applied as communications and cleantech. New technology of finance and management is not less important that the development of the technology itself. In next years we expect new forms of venture and innovation funds, and new management approaches to innovation.


Neutral-to-ground overvoltage may occur in noneffectively grounded power systems because of the distributed parameters asymmetry and resonance between Petersen coil and distributed capacitances. Thus, the constraint of neutral-to-ground voltage is critical for the safety of distribution networks. In this paper, an active grounding system based on a single-phase inverter and its control parameter design method is proposed to achieve this objective. Relationship between its output current and neutral-to-ground voltage is derived to explain the principle of neutral-to-ground voltage compensation. Then, a practical current detection method is proposed to specify the reference of compensated current. A current control method consisting of proportional resonant and proportional integral (PI) with capacitive current feedback is then proposed to guarantee sufficient output current accuracy and stability margin subjecting to large range of load change. The PI method is taken as the comparative method and the performances of both control methods are presented in detail. Experimental results prove the effectiveness and novelty of the proposed grounding system and control method.


The rapid expansion of foreign direct investment( FDI) facilitates high-speed economic growth in China,and inevitably results in the increase of CO2emission. This paper compares the impact of FDI and that of domestic investment on CO2emission based on provincial panel data of China from 1999 to 2011. It shows that there is a long-term relationship amongst CO2emission,foreign investment,domestic investment,industrial structure and urbanization level. Although investments from both domestic and foreign enterprises increase CO2emission in China,the foreign enterprises have less impact on CO2emission. A 1% increase in FDI leads to increase CO2emission by 0. 22% and CO2emission per capita by 0. 20%. A 1% increase in domestic investment leads to increase CO2emission by 0. 42% and CO2emission per capita by 0. 32%. The panel data analysis also shows the raise of the secondary industry proportion and urbanization level increase CO2emission in China significantly.


The total-field/scattered-field (TF/SF) formulation is widely used to initiate incident waves for scattering problems in finite-difference time-domain (FDTD) simulations. An important aspect of the TF/SF formulation is the calculation of incident fields at the TF/SF boundary by methods that account for the numerical nature of the incident wave in the FDTD grid. Failure to do so can lead to high levels of field leakage errors across the TF/SF boundary. This paper presents an improved analytic time-domain method for accurately computing incident fields in the TF/SF formulation. Using analytic field expressions with higher-order dispersion and polarization compensations, the proposed method compensates for 1) the FDTD numerical dispersion; and 2) the lack of orthogonality between the frequency-dependent field polarizations and the wavevector, which was not accounted for in existing analytic time-domain methods. The higher-order compensations result in further suppression of field leakage errors in the SF region. In addition to exciting a plane wave, the proposed method can be employed to excite an incident beam. To demonstrate this, numerical experiments that source both 3-D plane wave and focused beam into a free space FDTD grid are presented and compared with existing methods.


The appropriate electronic traps and energy gap between the bottom of the conduction band (CB) and the excited state of the luminescence center are crucial factors for excellent persistent luminescence (PersL) performance. In this paper, the possibilities of regulating electronic traps and the energy gap mentioned above are investigated via partial substitution of the host lattice cation Zr4+ by Hf4+. A comprehensive study on the structural transformation, luminescent properties and PersL decay curves were carried out to unearth the influence of partially substituting Zr4+ ions by Hf4+ ions. The broader band gap was revealed by diffuse reflectance (DR) spectra and Density functional theory (DFT) calculations, which ascribed to the relatively higher energy levels of Hf 5d state compared with Zr 4d state. Whereas, the thermoluminescence (TL) spectra show a successive red-shift due to the broader band gap and the deeper trap depth from the bottom of the CB to the trap energy levels. Guided by regulating the ...


What can romantic comedies teach us about response adaptive randomization for clinical trials? The answer might be surprising.In the mid 1940s, the British epidemiologist and statistician A. Bradfo...


BPMN models are often used by researchers to illustrate and validate new approaches that operate over such models. However, not always models are distributed in their source format but they are distributed as images within a document (e.g., a scientific contribution). To actually reuse those models, one has to manually redraw them. Manually redrawing a BPMN model is a time-consuming and error-prone activity. In this work, we present BPMN-Redrawer a tool that makes use of machine learning techniques for supporting the redrawing of BPMN models from images to actual models in .bpmn format. The tool is made available open source and it is open to contribution from the community.


Biomedical imaging is the key technique and process to create informative images of the human body or other organic structures for clinical purposes or medical science [...].


BACKGROUND/PURPOSE
The authors studied the potential role of ureteropelvic junction obstruction (UPJ-O) in causing progressive renal damage in children through the renal expression of epidermal growth factor (EGF) and monocyte chemotactic protein-1 (MCP-1) mRNA.

METHODS
Renal tissues were harvested from 11 children with UPJ-O and from 10 normal kidneys to study the renal expression of EGF and MCP-1 detected by means of in situ hybridization. Five of the patients were found to have a history of urinary tract infection (UTI).

RESULTS
Children with UPJ-O had marked reduction of EGF gene expression when compared with controls. Interstitial expression of MCP-1 mRNA was present in all UPJ-O cases. Both EGF and MCP-1 expression did not correlate with age, with differential renal function, and with renal thickness measured through MAG3 renal scan. Children with a history of UTI had a more severe reduction of the renal thickness of the affected kidney compared with those without UTI. MCP-1 expression was higher and EGF more reduced in children with a history of UTI.

CONCLUSIONS
Our results suggest a potential role of EGF and MCP-1 in the pathogenesis of renal damage and growth failure in UPJ-O, especially in children with UTI. These important functional changes begin early in life, possibly during fetal life.


The typical antipsychotic drug haloperidol causes vacuous chewing movements (VCM) in rats, which are representative of early‐Parkinsonian symptoms or later‐onset extrapyramidal side effects of tardive dyskinesia (TD) in humans. Haloperidol (HP) has been hypothesized to potentiate increases in oxidative stress or free radical‐mediated levels of toxic metabolites in rat striatum while simultaneous upregulating dopamine (DA)‐D2 receptors leading to presumed DA supersensitivity. Alpha(α)‐Phenyl‐N‐tert‐butylnitrone (PBN) is an antioxidant used to combat oxidative stress and measure increases in PBN spin‐adduct activity. Thus, the aim of this study was to investigate whether VCMs are related to upregulation of DA‐D2 receptors or to increased levels of free radicals produced during oxidative stress, and whether PBN had any protective effects. Rats received daily chronic (28 day) i.p. injections of saline, haloperidol (2 mg/kg), PBN (150 mg/kg), or haloperidol + PBN. The VCM model was used to measure extrapyramidal side effects of drug treatments. Electron spin resonance (ESR) spectroscopy was performed to compare concentrations of free radical species in rats receiving injections of HP + PBN. To examine the upregulation of DA‐D2 receptors, binding assays were carried out to assess the increase in DA‐D2 receptor numbers with respect to VCMs following treatment of rats injected with HP, PBN, and HP + PBN. Results of these experiments show that HP‐induced VCMs in rats results from increases in oxidative cellular events and may not be related to increases in striatal DA‐D2 receptors. Synapse 54:156–163, 2004. © 2004 Wiley‐Liss, Inc.


Significant features of Mobile Ad Hoc Networks make it suitable for modern military communication. These characteristics also weaken the security aspects in terms of attacks. Among the attacks, black hole and grey hole attacks are notable since they are launched internally and cannot be identified easily. The military communication requires confidential information sharing, ensuring correct identity of soldiers but offering such facility in military based MANET is difficult due to its unique nature. As providing authentication is a first form of security, in this article we propose a trust based security model to identifying black hole and grey hole nodes that weaken or collapse the success of mission in military communication. To provide authentication, we incorporate soldier's interpersonal characteristics in terms of Stereo trust, Situational Awareness trust and soldier's operational things in terms of first-hand information, second hand information and soldier's current trust. Simulation results show the efficiency of our proposed model in terms of identifying black hole and grey hole nodes and its performances are compared with an existing model.


Computer games create realistic and interactive spaces for people with the developing technology in virtual extent and they also build quotations surrounding every aspect of human perception. Computer games are not only a leisure time activity but also a transmedia case related to perception and the identification process. Another important factor of the computer games are graphics of the games. The main purpose of this chapter is to consider the relation of the technical level of the game in a graphical three-dimensional model to identification process in the context of "identification with the avatar." The Witcher 3: Wild Hunt which was driven to the market and received positive criticism with its successful graphics will be analysed in the context of its transmedia features and graphic design. Then, a semi-structured interview will be conducted with 15 gamers who played The Witcher 3: Wild Hunt, to analyse the relation of "identification with the avatar process" of the participants to the graphical modeling of the game.


Job stress is a condition due to an interaction between worker with the job which cause discrepancy between individual characteristics with conditions around the company. Job stress can affect worker's performance and productivity while doing their task. One factor that can affect job stress is working condition. This study aimed to see the influence between working condition with job stress. This study uses quantitative methods. This study is a population study with 135 fuel oil tank driver of PT Elnusa Petrofin Dumai. Measuring instruments used in this study are job stress scale and working condition scale. Job stress scale based on symptoms of job stress by Beehr and Newman (in Rice, 1987) and working condition scale based on aspects of working condition by Mangkunegara (2007). Result of analysis of research data simple regression analysis showed that there's a influence of working condition toward job stress. Keyword : job stress, working condition, fuel oil tank driver Universitas Sumatera Utara


Symptomatic and pathogenetic treatment of cystic fibrosis allowed to increase patients' lifespan up to 30 years, but disease is still incurable. New gene therapy technologies based on the use of specific nucleases open up new opportunities in development of etiology-based therapy for hereditary diseases. Among these methods CRISPR/Cas9 is the most widely used approach for genome editing. The aim of the study is to compare correction efficacy of CFTR gene by Cas9 with different guide RNAs (sgRNAs), designed to F508del mutation, and to increase their activity. We used modified spCas9 (eSpCas9) and two sgRNAs designed to CFTR gene: sgCFTR#1 - directly to the F508del mutation and sgCFTR#2 - 14 nucleotides 5'-upstream from the mutation. SgGFP designed to GFP gene was used as a control of the nuclease activity. PGEM-TA-CFTR plasmid with part of the CFTR gene with the F508del mutation co-transfected with the plasmid for CRISPR/Cas9 was used as template for sgCFTR#1 and #2; plasmid pEGFP-C1 was used as template for sgGFP. Experiments performed in HEK293T cell culture demonstrated, that sgCFTR#1 has the lowest efficiency among used sgRNAs - number of insertions/deletions (indels) by T7E1 assay was 6.37-20.82%. Expression level of sgCFTR#1 after transfection was lower than expression of sgGFP, which showed the greatest activity - up to 65% of indels. Addition of G-quadruplexes to sgCFTR#1 and sgGFP sequences with the aim to increase their stability led to decrease of expression and activity. Culturing transfected cells at lower temperature (24 hours at 37°C, then 48 hours at 30°C) resulted in two-fold decrease of sgCFTR#1 activity, but without affecting sgGFP activity. Thus, direct relationship between sgRNAs expression and their activity was confirmed in the study; however, sgCFTR#1 expression and its efficacy could not be increased. Further attempts to enhance sgCFTR#1 expression and its stabilization should be performed, or other Cas9 enzymes, which expand the ability to select sgRNA direct to F508del mutation can be potentially used.


Model checking is a promising technique for automated verification and validation in the early stage of safety critical software development. Nevertheless, the routine use of the technique in practice has not been possible mainly because of the lack of tool support that integrates the technique into the engineering process and the limitation of the technique to relatively small scale finite state systems.
In particular, model checking techniques have not been effective in important classes of software systems—systems characterized by large (or infinite) input domains with interrelated constraints over the system variables. Various process is manual and requires a great deal of ingenuity, or (2) the require special purpose model checkers.
data values that subsume all possible system behaviors. The technique is more generally applicable than previously proposed techniques in the sense that it is independent of specific model checking techniques, and thus, can naturally blend into the verification process regardless of which tools are being used. Applications of a prototype implementation of the technique show its promise in practice.


Abstract:During difficult times, many argue that science will come to our rescue. Investment in science, technology, data, and innovation is seen to be vital if we are to tackle the most pressing concerns facing society. But not everyone shares this enthusiasm: Whether it be anti-vaxxers or climate change deniers, there has been an increased adoption of populist views that seemingly reject the rationalism of science. This rise is not evidence of a public rejection of rational thinking, however, but rather a growing difference in the way people experience the effects of science and technology. Rather than a perceived crisis of trust, our biggest source of concern should be the different ways that technology shapes our worlds.


Electrohydraulic lithotripsy was performed on ureteral calculi of various sizes and composition in 10 female mongrel dogs. Stones were successfully disintegrated in eight dogs with an overall 80 per cent success rate. Short- and long-term effects of the procedure on the ureter and the kidney are discussed.