The mathematical model on polymer-surfactant flooding is established in this paper. The viscosity of polymer-surfactant solution with different concentrations is measured with Brookfield Viscometer. On this basis, the polymer-surfactant injection concentration and quantity are optimized by the numerical simulation method. The geologic model controlled by facies is built. Then numerical simulation research using STARS module of software CMG is progressed. The influence with different injection concentration and quantity on development effect is studied. The results show that the critical concentration of polymer-surfactant is 1250mg/L, optimized injection concentration of polymer-surfactant is 1500mg/L, optimized injection quantity of polymer surfactant is 1PV. This study results are significant to the actual production of the oilfield.


According to the present cultural relics and historic sites preservation situations in Changsha the advantages of Changsha as national famous historical and cultural city and the problems exited are discussed. In view of conservation of cultural relics and historic sites corresponding strategies are presented.


We carried out high-cycle internal pressure fatigue tests using a large number of thin-wall cylinders of austempered ductile iron (ADI). As a result, we observed a distinctive feature often seen in high-strength steel, that the SN diagram inclined again after about 107 cycles, in spite of once revealing a horizontal part at 106- 107 cycles, and that an obvious fatigue limit could not been observed. Corresponding to this characteristic SN diagram, Weibull plots of the fatigue data were dramatically changed between high-and low-pressure levels. The thorough SEM observation of the fracture surfaces clarified that the fracture origins changed from casting defects to relatively small graphite particles between high-and low-pressure levels. This means that different fracture mechanisms exist between high-and low-pressure levels. These two mechanisms competed in the high-cycle region and brought about the distinctive fatigue behavior of ADI.


B16H20 and [RhCl2(eta5-C5Me5)]2 with tmnd give [(eta5-C5Me5)2Rh2B11H15], which has an unprecedented thirteen-vertex macropolyhedral cluster core based on a nido ten-vertex {MB9} subcluster and a nido five-vertex {MB4} subcluster fused with their open-face {B2} edges in common.


The article presents a study of the state of use of educational information for the preparation of bachelors in cybersecurity. The key bases of the legislative base of Ukraine are analyzed. Based on a number of studies of the use of the Internet in the process of training bachelors in cybersecurity, the state of perception of different types of educational information by future bachelors in cybersecurity and the use of device types in the training of bachelors in cybersecurity. bachelors in cybersecurity.The subject of the research is the issues related to the means for learning on the Internet, social networks, distance learning courses, mass open distance courses, YouTube channels with interactive self-assessment of knowledge and in learning environments by means of network simulators for programming. The aim of the work is to publish the results of a study conducted during three semesters in order to study the state of use of educational information for the preparation of bachelors in cybersecurity. The methods of the conducted work include the method of interviews and questionnaires. The published results show that there is an increasing need to use distance learning courses, mass open distance courses, interactive YouTube channels for self-assessment of knowledge and in learning environments using network simulators for programming. The scope of the results is a methodological field for improving the methodology of training bachelors in cybersecurity, which require the use of electronic content, educational environments and communication systems in an educational-digital environment.


Abstract : The main objective of this research project is the development of a non-invasive method and instrument for head injury detection and monitoring using a new approach based on ultrasonic and low-frequency acoustic (ULFA) soundwave detection.


Eighty years after the first science fiction convention, geek culture has gone mainstream and facilitated exponential growth in the fandom convention industry. With fandom conventions facing increasing competition and changing demographics, standing out in the crowded convention space is essential. Dragon Con founded in 1987 created the idea of the multi-genre convention that has something for everyone. Since its inception, Dragon Con has changed to fit fans' evolving tastes and formed strategic relationships with key partners. With growth comes issues related to registration, wait lines, harassment and security which need to be addressed while trying to take into account the younger and more diverse fandoms.


In switching converters very often the magnetic circuit part can seriously affect the converter electrical circuit performance, such as frequency response, for example. Conversely, the electrical circuit may impose undesirable waveforms upon the magnetic circuit and make it inefficient. The causes of these magnetic and electric circuit interactions in sWitching converters are uncovered. The proposed solutions are verified on a 220W, five output off-line switching power supply for high resolution color monitors meeting very stringent military specifications. This design case study also addresses a number of important practical issues such as: optimum design of the six-winding coupled-inductor structure, EMI design for low noise, and start-up transient problems as well as several other practical problems encountered during the manufacturing phase.


The present invention discloses a flexible HVDC valve MMC overcurrent shutdown test methods and systems, the method proceeds by a corresponding system as follows: (1) connecting the test valve and the load circuit and charging power supply, for the sample valve charge; (2) according to the current load circuit of the selected peak magnitude of load reactors test set; (3) selecting the test target sample valve according to the test object, and changes the changeover switch corresponding to the load circuit; (4) provided subjects given sample time trigger valve, the degree of pressure detecting valve sample; and (5) the discharge valve is closed test switch, the test ends. The present invention fully satisfies the overcurrent shutdown valve MMC test requirements, may be provided with the actual operating conditions corresponding to the transient thermal strength, the strength of the fault current transient, transient high voltage strength, strength loss attachment circuit, the current rate of change in intensity, the intensity of the voltage change rate, provide a basis for the actual working conditions.


Veress, E. (2023) 'The Hungarian Golden Bull – an 800-year-old medieval charter of freedom' in Balogh, E. (ed.) Golden Bulls and Chartas: European Medieval Documents of Liberties, pp. 9–14. Budapest – Miskolc: Ferenc Mádl Institute of Comparative Law – Central European Academic Publishing. https://doi.org/10.47079/2023.eb.gbac.1_1 THE HUNGARIAN GOLDEN BULL – AN 8oo-YEAR-OLD MEDIEVAL CHARTER OF FREEDOM


Abstract : The structural properties and electrical activity of impurities (indium, arsenic, antimony) and self-interstitials (mercury, cadmium, tellurium) in CdTe and HgCdTe alloys have been studied by theoretical and computer calculations, The problems addressed included: - the source of the midgap tunneling levels in Hg-rich HgCdTe, - the cause of electrical inactivity in In- doped CdTe grown by non-photoassisted molecular beam epitaxy (MBE), - identification of paths for impurity and self-diffusion, - the effects of lattice distortion on defect properties and interaction.


This paper proposes a compressive pulse-Doppler radar that works through one-bit quantization of the received noisy signal. The one-bit quantization is performed by comparing the signal with a time-varying reference level. Considering the sparsity of the targets in the range-Doppler domain, the problem is dealt with by a sparse recovery method. The proposed method leads to an optimization problem that can be tackled by a convex approximation. Numerical examples show that the proposed method has a promising performance in the detection/estimation of the target parameters. Moreover, it is seen that in low signal to noise ratio, increasing the sampling rate at the receiver side is a compensating factor that effectively improves the performance.


Should the ancient Greeks - "the oldest dead white European males" - and their legacy have any relevance to the way we live now? So much of what the ancients were and did may now appear positively racist and sexist in this era of multiculturalism. Yet for all their flaws, the Greeks gave us Homer Sappho, Plato, Aristotle, Sophocles and Thucydides, to name a few. They invented much of what we now take for granted: the idea of the humanities, philosophy, the theatre, competitive athletics, political theory, rhetoric and oratory, biology, zoology and atomic theory. In this book, Bernard Knox raises questions that are of fundamental importance for our age.


For the past decade, the standard treatment for patients with metastatic renal cell carcinoma has been the sequential use of single agents targeting the vascular endothelial growth factor (VEGF) and mammalian target of rapamycin (mTOR) pathways. Efforts to combine VEGF- and mTOR-targeted agents have been for the most part disappointing, with limited evidence of increased activity at the expense of greater toxicity. However, preclinical work has shown that combining the multitarget tyrosine kinase inhibitor of VEGFR lenvatinib …


There is an increase in the adoption of radars into automobiles as it is robust to weather changes and provides direct range and velocity measurements. Several low-height static targets such as humps and potholes are difficult to detect in regular vehicles, especially when covered with water. Hence, it is necessary to study their detection based on how they interact with radar waves which are characterized by their radar cross-section (RCS). In this work, a detailed methodology for estimating the RCS of humps and potholes has been presented, and its detection is studied in two different radar waveforms, frequency-modulated continuous waveform (FMCW) and orthogonal frequency division multiplexing waveform (OFDM).


The use of machine learning for the image classification process is growing all the time. Many methods can be used to classify an image with good accuracy. Convolutional Neural Network (CNN) and Support Vector Machine (SVM) are popular methods for this case. The two approaches have differences in the data training process to achieve classification objectives. Although there are some differences between these approaches, there are some advantages to both of them. This research explores the comparison of the two CNN and SVM methods by comparing the training process carried out and the accuracy results of the classification. The process stages are divided into pre-processing, training, and testing. The objects used are ten waste plastic bottles with different brands of medium size with a total data of 1100 images. Based on the observations, both methods have advantages and disadvantages in the data training and classification process. However, from the results, CNN's accuracy is better than SVM. The accuracy of both networks is 99% for CNN and 74% for SVM, respectively. So, from the results of experiments that have been carried out in the study, it was found that CNN was still better than SVM. Doi: 10.28991/ESJ-2022-06-05-011 Full Text: PDF


Abstract This article addresses the lack of outcome-based research on the integration of technology into pedagogy at the undergraduate college level. It describes a study performed at a Midwestern university, testing the relative effectiveness of paper and electronic topographic maps for teaching map-reading skills, and considers the relationship between learning styles and paper or digital map preference. Results indicate that, although student map skill performance did not differ significantly with the use of paper or electronic maps, students preferred paper maps. Neither their performance nor their preferences were related to learning style. The article discusses the significance of these findings.


The British Veil Wars maps the space of the British debates on Islamic women's apparel and identifies the political conditions and structures that direct the non regulation of its practice in public institutions, such as schools. The article argues that despite the poignant political dilemmas caused by the 2006 'veil debate' on the niqab (face veil) statutory regulation against its practice was not foreshadowed and the reasons most succinctly identified against its non - regulation is due to not only Britain's citizenship regime but also because of the church and state establishment as well as Article 9 of the European Commission of Human Rights. The article leads to reflections about the process by which the veil became constructed as a response to the political imperatives and failures of British multiculturalism.


Over a period of some 20 years thera has been so :nu3h prorainence jiven to Quarantine 37 that the fact is almost always completely disregarded that the plant quarantines placed by the united States Depart.aent of A^^riculture must be placed under authority of the Plant i^uarantine Aot passed by Congress mor*^ than 26 years apo. he!: any chanre is made or su^-gested in nursery stoc.'c import requirerjents there invariably comes a flood of telegrams anc' petitions, all saying the same thing in just about the sairie words: "Maintain 'o.uarantine I'o. 57 ^s is." In general, these demands come Irom certain f:roups interested in some one class of nurs ry ?tock. They could not come fron pe.^ple j. amiliar vdth ^.uarantine 37 because such people v;ould not Avant Quarantine 37 maintained as is. 11 they v/ere really interr'sted in keepin.-; the country free of ffes'cs they v/ould want Qua~--£.ntine 37 chanr-.ed. iiot only that, they <;ould \-ant the Plant 'Ai.arantine Act so changed as to insure as nearly as such things can be that plcjnt pests bo kept out.


This study evaluated natural gas hydrates recovered from three different wells (J13R, J07RB, and J23R) at the Umitaka Spur in the Joetsu Basin, via Raman spectroscopy. The hydrates in two of the sa...


The technological tender is the main part of tender book it is a promise for the inviting to a tender organization and a guidance document after being chosen in the tender book.This paper discusses some problems that should be placed particular emphasis on when the technology tender is drew up.


Cl atoms in the marine atmosphere may signif- icantly impact the lifetimes of methane and other hydro- carbons. However, the existing estimates of Cl atom lev- els in marine air are based on indirect evidence. Here we present measurements of the Cl precursors HOCl and Cl2 in the marine boundary layer during June of 2009 at the Cape Verde Atmospheric Observatory in the eastern tropical Atlantic. These are the first measurements of tropospheric HOCl. HOCl and Cl2 levels were low in air with open ocean back trajectories, with maximum levels always below 60 and 10 ppt (pmol/mol), respectively. In air with trajectories orig- inating over Europe, HOCl and Cl2 levels were higher, with HOCl maxima exceeding 100 ppt each day and Cl2 reach- ing up to 35 ppt. The increased Cl cycling associated with long distance pollutant transport over the oceans likely im- pacts a wide geographic area and represents a mechanism by which human activities have increased the reactivity of the marine atmosphere. Data-constrained model simulations indicate that Cl atoms account for approximately 15 % of methane destruction on days when aged polluted air arrives at the site. A photochemical model does not adequately sim- ulate the observed abundances of HOCl and Cl2, raising the possibility of an unknown HOCl source.


With the widespread application of artificial intelligence technology in the military field, a distributed networked electronic warfare system consisting of a large number of confrontation nodes based on unmanned intelligent platforms is emerging. Due to the characteristics and advantages of intelligence, coordination, self-adaptation, and selforganization, distributed electronic warfare networks have become an important research direction in the current electronic warfare field1 . The research of combat system based on complex network provides a new perspective for the research of combat command and control system, which helps people to grasp the complexity of networked warfare as a whole, and to better understand its topological structure and corresponding dynamics feature. This paper analyzes from the characteristics of distributed electronic warfare network, introduces the HK (Holme-Kim) network model, and combines the operational characteristics of distributed electronic warfare system, selects HK (Holme-Kim) network model to build a complex network model of distributed warfare network, and analyzed its advantages.


We developed useful databases of cardiovascular agents to support the drug information service for patients, medical doctors and nurses. This system consists of six databases, including : 1) various information data about drug efficacies, cautions, warnings and contraindications, side effects, prudent medication, drug interactions, pharmacokinetics for 148 medicines, 2) relief information regarding disease state for cardiomyopathy and heart failure, 3) the search method to identify corresponding drugs from side effect data, 4) the mechanisms and the grade of drug interaction, 5) international mega trials regarding cardiovascular drugs, 6) connection with the information leaflets for patients already developed in our hospital. We are able to refer to information data by connecting these databases with each other on a notebook PC and thereby quickly provide accurate information.


The conclusions, to which the author comes, on the basis of a thorough study of someone else's and his own rich material, differ significantly from the scientific provisions prevailing on this subject.


Medical Response to Major Incidents (MRMI) is a standardized postgraduate course developed by an international group of experts within the European Society for Trauma and Emergency Surgery. It is entirely interactive, with all participants training in their routine positions. It covers the whole chain of management—scene, transport, hospitals, command and communication, management of individual patients—and thereby permits training in the important coordinating between different units, which often is the weak point in real incidents. The scenarios are based on real injuries from terrorist incidents. The training is done in real time using actual simulated resources, thereby providing a measurable result of the response as a base for further development and training.


A multi-agent median computerized adaptive testing (CAT) system is put forward, which is based on the three-parameter logistic model (3PLM) of item response theory (IRT) and a multi-agent item pool. The multi-agent item pool is proposed to help the non-professionals system choose valuable items interactively and conveniently . Aiming at the problems in the ability estimate of multi-agent adaptive testing, rapid convergence can be realized greatly if logistic median algorithm is applied to calculate maximum likelihood estimation (MLE) instead of the most commonly used Newton_Raphson iterative algorithm. Simulated experiments are conducted with the research object of multi-agent three parameter logistic median model. The result shows that this CAT system has more superior function and lower calculation quantity, with fast convergence and the accuracy of ability estimate, which will be adapted further in modern test system.


Aiming at improving the survey efficiency of the Wide Field Survey Telescope (WFST), we have developed a basic scheduling strategy that takes into account the telescope characteristics, observing conditions, and weather conditions at the Lenghu site. The sky area is divided into rectangular regions, referred to as 'tiles', with a size of 2.577◦ × 2.634◦ slightly smaller than the focal area of the mosaic CCDs. These tiles are continuously filled in annulars parallel to the equator. The brightness of the sky background, which varies with the moon phase and distance from the moon, plays a significant role in determining the accessible survey fields. Approximately 50 connected tiles are grouped into one block for observation. To opti mize the survey schedule, we perform simulations by taking into account the length of exposures, data readout, telescope slewing, and all relevant observing conditions. We utilize the Greedy Algorithm for scheduling optimization. Additionally, we propose a dedicated dithering pattern to cover the gaps between CCDs and the four corners of the mosaic CCD array, which are located outside of the 3-degree field of view. This dithering pattern helps to achieve relatively uniform exposure maps for the final survey outputs.


Abstract: This study has as objective to verify the convergence betwixt Infant Mortality Rate decreasement and Human Development Index Municipal increasement in Big Regions and Federation Units in Brazil between 2000 to 2010. The type of study adopted is ecological. It is drawn to a conclusion that the Infant Mortality Rate's reduction and the Human Development Index Municipal's increase, happened in a non-homogeneous form in the areas of study.


There exist several observers for some particular nonlinear systems, such that the norm of the estimation error decays to zero irrespective of the input. However, observability of nonlinear systems is known to be dependent on the input. This is why this paper intends to help understanding how such observers can work, by proposing sufficient conditions for a class of non-uniformly observable systems ensuring the existence of an observer stable for any input.


Andre Lefevere's is a familiar name in Translation Studies. He has been around for some twenty years, publishing furiously and often provocatively. He has changed over the years, too, and his career mirrors some of the paradigmatic sea-changes in the field. His first book, Translating Poetry: Seven Strategies and a Blueprint (1975), still viewed literary translation as a loss-making business and tried to distil the optimum strategy from among a number of available options. He would soon shake off the normative touch, and in Literary Knowledge (1977), probably his least-known book, went in search of a new conceptual framework for the study of literature and translation. This was the time when the descriptive, target-oriented, polysystem-based approach was rearing its head, and Lefevere, together with scholars like Gideon Toury, Raymond van den Broeck, and Jose Lambert, proved one of its most polemical and effective voices. During these years he also brought out his best-known collection, Translating Literature: The German Tradition (1977), and collaborated with Van den Broeck on a Dutch-language Invitation to Translation Studies (1979). He went on to carve out his own niche, moving from the Low Countries to Austin, Texas, and gradually devising his own concepts and


Our Numerical Spectral Model (NSM), which extends from the ground up into the thermosphere, is non-linear, time-dependent and has been employed for 2D and 3D applications. The standard version of the NSM incorporates Hines' Doppler Spread Parameterization for small scale gravity waves (GW), but planetary waves generated in the troposphere have also been incorporated. The NSM has been applied to describe: (1) the anomalous seasonal variations of the zonal circulation and temperature in the upper mesosphere, (2) the equatorial oscillations (quasi-biennial and semi-annual oscillations (QBO and SAO)) extending from the stratosphere into the upper mesosphere, (3) the diurnal and semi-diurnal tides, and (4) the planetary waves that are excited in the mesosphere. With the emphasis to provide understanding, we present here results from numerical experiments with the NSM that shed light on the GW processes that are of central importance in the mesosphere and lower thermosphere. These are our conclusions: (1) The large semiannual variations in the diurnal tide (DT), with peak amplitudes observed around equinox, are produced primarily by GW interactions that involve, in part, planetary waves. The DT, like planetary waves, tends to be amplified by GW momentum deposition, which reduces also the vertical wavelength, but variations in eddy viscosity associated with GW interactions are also important. (2) The semidiurnal tide (SDT) and its phase in particular, is strongly influenced by the mean zonal circulation. The SDT, individually, is also amplified by GW. But the DT filters out GW such that the GW interaction effectively reduces the amplitude of the SDT, producing a strong nonlinear interaction between the DT and SDT. (3) Without external time dependent energy or momentum sources, planetary waves (PW) are generated in the model for zonal wavenumbers 1 to 4, which have amplitudes in the mesosphere above 50 km as large as 40 m/s and periods between 50 and 2 days. The waves are generated primarily during solstice conditions, which indicates that the baroclinic instability (associated with the GW induced reversal in the latitudinal temperature gradient) is playing an important role. Numerical experiment show that GW, directly, also greatly amplify the PW. A common feature of the PW generated in summer and winter is that their vertical wavelengths throughout the mesosphere are large, which indicates that the waves are not propagating freely but are generated throughout the region. Another common feature is that the PW propagate preferentially westward in summer and eastward in winter, being launched from the westward and eastward zonal winds that prevail respectively in summer and winter at altitudes below 80 km. (4) Planetary waves generated internally by baroclinic instability and GW interaction produce large amplitude modulations of the DT and SDT. In summary we conclude that GW play major roles in generating and amplifying the dynamical components in the MLT region and, acting principally through wave filtering, produce important non-linear interactions between the components.


BACKGROUND
Rheumatoid arthritis (RA) is a chronic autoimmune disease, which destructs joints and causes significant pain, impairing a patient's quality of life. Strychni semen showed promising results in treating RA. However, there are increasing safety concerns in using Strychni Semen due to its severe toxicity.

AIM AND OBJECTIVE
The purpose of this review is to provide insight into using Strychni Semen as an alternative medicine to treat RA, as well as to offer a method for the safe application of Strychni Semen through processing and compatibility studies.

METHODS
Publications were retrieved and surveyed from CNKI and PubMed relevant to Strychni Semen for a literature review.

RESULTS
This article summarized the mechanism of function of strychni semen in treating RA with its anti-inflammatory, analgesic, and immunomodulatory effect. Commonly used methods to attenuate the toxicity of strychni semen were also discussed in this article.

CONCLUSION
Strychni semen has a good therapeutic effect on RA, mainly by the modulation of immunity with anti-inflammatory and analgesic effects. Also, the reported toxicity of strychni semen can be effectively reduced by processing and reasonable compatibility. Hence, as an alternative medicine for RA treatment, strychni semen has a broad prospect.


The well-noted correspondence between gravitation and electrodynamics emphasizes the importance of the Lanczos tensor—the potential of the Weyl tensor—which is an inherent structural element of any metric theory of gravity formulated in a 4-dimensional pseudo Riemannian spacetime. However, this ingenious discovery has gone largely unnoticed. We elucidate this important quantity by deriving its expressions in some particularly chosen spacetimes and try to find out what it represents actually. We find out that the Lanczos potential tensor does not represent the potential of the gravitational field, as is ascertained by various evidences. Rather, it is enriched with various signatures of quantum character, which provides a novel insight into the heart of a geometric embodiment of gravity.


The review presents the data on clinical diagnostic value of studying one of the components of urinary proteome - macrophage chemotactic protein -1 (MCP-1). Along with the general characteristics of MCP-1, there are given the data on changes in its concentration regarding various diseases of the urinary system. It was shown that for various diseases and research conditions, the concentration of MCP-1 can be an important diagnostic criterion in assessing inflammatory, metabolic, fibrotic and other renal lesions.


The Color Atlas of Dental Hygiene-Periodontology is the newest periodontal textbook primarily intended for dental hygiene students and all the other participants in their education. The atlas is divided into three big areas which are subdivided into chapters by which the authors lead us through basic knowledge in periodontology and numerous treatment options. In the first chapter a thorough explanation of the anatomy of the periodontium, etiology, and pathogenesis and host response of periodontal disease is given. A clear emphasis is given on the importance of immunology, genetics and the issue of destruction and repair of periodontal tissues. In the second chapter a detailed classification of periodontal diseases and new diagnostic procedures are given. Every disease is clearly and concisely described and is accompanied by numerous photographs from daily practice. The treatment chapter encompasses everything from urgent procedures on the periodontium to the preservation of achieved results. The chapter ̋Initial therapy 1 ̋ is especially suited for new dental hygiene students giving them a complete understanding of their future profession. Numerous illustrations and clinical case examples are explained in a clear and simple way in the text and provide all the necessary data. Innovations and new scientific evidence are lucidly presented and show new approaches to the etiology, diagnostic and treatment of periodontal diseases. This atlas is in a way a shortened version of one of the best atlases in periodontology of prof. Rateitschak, whose third edition was edited by the same authors who edited this atlas. This is a proof of the quality of this atlas. At the end, although this is intended to be an atlas for dental hygienists, it can serve to dental students as well as a useful textbook.


iii Acronyms and Abbreviations vii 1.0 Introduction 1.1 1.1 Fiscal Year 2012 Work Plan and Objectives 1.1 1.2 Summary of FY 2012 Activities in the Deschutes Basin 1.2 2.0 Scenarios 2.1 2.1 Opportunities to Increase the Benefits Derived from Water Resources 2.1 2.2 Scenarios 2.1 2.2.1 Scenario 1: Baseline 2.1 2.2.2 Scenario 2: Deschutes River: Integrated 2.1 2.2.3 Scenario 3: Crooked River Sub-basin: Integrated 2.3 2.2.4 Scenario 4: Upper Deschutes River Basin 2.5 2.3 Remaining Work and Expected Outcomes 2.5 3.0 Improved Hydrology Modeling to Account for Water in the System 3.6 3.1 Description 3.6 3.2 Technical Approach 3.6 3.2.1 Existing Modeling of Water Resources 3.6 3.2.2 Modeling Enhancement 3.8 3.3 Remaining Work and Expected Outcomes 3.17 4.0 Data Visualization 4.18 4.1 Three Levels of Data 4.18 4.2 Dashboard View 4.20 4.3 Remaining Work and Expected Outcomes 4.21 5.0 Conclusions and Next Steps 5.22 6.0 References 6.1


With the rapid development of computer technology, Internet technology and artificial intelligence technology, the amount of global data has exploded. However, the single-machine serial mode of traditional data mining cannot be directly transplanted to the cloud platform. Only by parallelizing and improving many classic data mining algorithms can the cloud computing platform and data mining be effectively combined. Therefore, it is of great significance to the research and implementation of parallel algorithm technology for time series data mining. The purpose of this paper is to study the research and implementation of parallel algorithm technology for time series data mining. This paper adopts the method of literature data, mathematical statistics, logic analysis and other research methods to study the parallel algorithm technology research and realization of time series data mining, mainly to make useful explorations of time series data mining and visualization technology. It embodies the design ideas of big data analysis tools, and finally reflects the power and market value of data analysis tools through the display of the platform. Research shows that running in the same data set and the same experimental environment, the improved parallel collaborative filtering algorithm ACF in this paper has higher time running efficiency than the parallel algorithm MCF based on the cooccurrence matrix, and in the case of larger data sets, the more obvious the time difference.


We present the first high resolution MHD simulation of cosmic-ray electron reacceleration by turbulence in cluster mergers. We use an idealised model for cluster mergers, combined with a numerical model for the injection, cooling and reacceleration of cosmic-ray electrons, to investigate the evolution of cluster scale radio emission in these objects. In line with theoretical expectations, we for the first time, show in a simulation that reacceleration of CRe has the potential to reproduce key observables of radio halos. In particular, we show that clusters evolve being radio loud or radio quiet, depending on their evolutionary stage during the merger. We thus recover the observed transient nature of radio halos. In the simulation the diffuse emission traces the complex interplay between spatial distribution of turbulence injected by the halo infall and the spatial distribution of the seed electrons to reaccelerate. During the formation and evolution of the halo the synchrotron emission spectra show the observed variety: from power-laws with spectral index of 1 to 1.3 to curved and ultra-steep spectra with index > 1:5.


The invention relates to a tissue fusion agent comprising a supporting element and a flock material. Furthermore, the invention relates to a surgical system comprising the tissue fusion agent according to the invention and a tissue fusion instrument. In addition, the invention relates to a method for producing a tissue fusion agent, comprising the steps of: a)coating a supporting element with an adhesive and b)flocking the adhesive-coated supporting element with a flock material while the adhesive is moist, adhesive or tacky, or after activation of the adhesive. Lastly, the invention relates to a method for producing a tissue fusion agent, comprising the steps of: a)at least partly transferring a supporting element to an adhesive or tacky state and b)flocking the at least partly adhesive or tacky supporting element with a flock material.


In the Journal, Liu et al. provide compelling evidence that acute spinal cord stimulation (SCS) improves myocardial energetics, ventricular function, and efficiency in a porcine model of postinfarct heart failure (HF).1 The presumptive mechanism for this improvement (not explored in this study) is attributed to both reduced sympathetic stimulation, and enhanced parasympathetic activity, which is thought to be vagally mediated.2,3 These salutary effects have been reported to occur even in the presence of neurohormonal blockade with beta-receptor blocker and angiotension inhibitor therapies.3 Compensatory changes in the autonomic nervous system activity are known to impact adversely the clinical course of HF and to cause a host of adverse structural changes that further worsen cardiac function. Advances in pharmacologic therapy for HF over the past 20 years have been achieved by attenuating these changes with drugs like betareceptor blockers, angiotensin converting enzyme inhibitors, angiotensin receptor blockers, and aldosterone antagonists. These therapies greatly improve functional status, cause neurohormonal and structural reverse remodeling, reduce hospitalization, and increase survival.4 There are compelling parallels between the pharmacologic neurohormonal agents and stimulatory neurohormonal therapy achieved with SCS.5 A confluence of animal and human data indicate that sympathetic activation can predispose to ventricular arrhythmias and that parasympathetic activation is protective.6,7 Similarly, particularly in HF, treatments that block excitatory neural traffic to the heart and achieve enhanced parasympathetic effects like beta-blocker receptor therapy and angiotension inhibitor therapy can increase the threshold to arrhythmia development and sudden death through direct and indirect effects.8-11 Issa et al. demonstrated in a canine model of postinfarction HF that SCS reduces the incidence of transient ischemia related ventricular arrhythmias while simultaneously decreasing sinus rate, increasing the PR interval, and reducing systolic blood pressure.12 Lopshire et al. evaluated the incidence of ventricular tachyarrhythmias with chronic SCS in canines after left anterior descending artery embolization and ICD implantation. The animals were assigned to control medical therapy (carvedilol), or SCS. After 10 weeks, the greatest recovery in


The utility model relates to a real-time data sampling device of a transformer station. The real-time data sampling device comprises sensors, a wireless communication network, and a sampling industrial personal computer (IPC). The sensors are connected with the sampling IPC through the wireless communication network and connected with electrical equipment in the transformer station. Compared with a product in the prior art, the real-time data sampling device has an advantage that environmental data of electrical equipment in the transformer station is sampled in real time and transmitted to the sampling IPC in real time.


This paper focuses on designing a distributed medium access control algorithm for fairly sharing network resources among contending stations in an 802.11 wireless network. Because the notion of fairness is not universal and there lacks a rigorous analysis on the relationships among the four types of most popular fairness criteria, we first mathematically prove that there exist certain connections between these types of fairness criteria. We then propose an efficient medium access algorithm that aims at achieving time fairness and throughput enhancement in a fully distributed manner. The core idea of our proposed algorithm lies in that each station needs to select an appropriate contention window size so as to fairly share the channel occupancy time and maximize the throughput under the time fairness constraint. The derivation of the proper contention window size is addressed rigorously. We evaluate the performance of our proposed algorithm through an extensive simulation study, and the evaluation results demonstrate that our proposed algorithm leads to nearly perfect time fairness, high throughput, and low collision overhead.


N 1964 CANCER OF THE LARGE BOWEL WAS I responsible for 41,763 d e a t h ~ l 4 . 4 ~ ~ of all deaths from cancer in the United States. I t accounted for more deaths than from any other type of cancer except pulmonary cancer. This investigation has attempted to uncover factors that might affect the development of cancer of the large bowel. Since etiological factors may affect them differently, at least in degree, the data for the various parts of the large bowel are presented separately. Pertinent incidence data will be presented first because they may offer important clues to the determination of etiological factors. Factors previously demonstrated or thought to affect the pathogenesis of this cancer will also be reviewed.


PMMA/CaCO3 nanocomposites have been fabricated by in-situ polymerization. The influence of concentration and stirring speed on tensile strength have been studied. The experimental results were optimized using Taguchi's approach. L9 Orthogonal arrays of Taguchi, the signal-to-noise (S/N) ratio and the analysis of variance (ANOVA) are employed to find the optimal input parameter levels and to analyze the effect of these parameters on tensile strength. Experimental results showed that tensile strength PMMA/CaCO3 nanocomposites increased up to 53 % at 0.6 wt. % CaCO3 and 1000 rpm in comparison to corresponding pure PMMA. The experimental results and various statistical approaches namely, Taguchi methods, Conceptual S/N ratio and drew similar conclusions. The ANOVA analysis showed that speed is more dominant in comparison to concentration.


Objective: We aimed to describe a case of congenital microcephaly caused by Zika virus infection in a monozygotic twin pregnancy. Methods: Transfontanelle ultrasonography and cranial computed tomography revealed different lesion patterns for both twins with congenital microcephaly caused by Zika virus infection. Motor development assessments were performed using the Alberta Infant Motor Scale and the Gross and Motor Function Measure before, during, and after physiotherapy. Results: The evaluations showed differences in motor acquisition between the twins. The values in the first case were much lower than those in the second case, which showed more motor delay. Conclussion: The present study showed that despite the twins being monozygotic, the effects of neurological lesions as revealed by neuroimaging were worse in the first case, and even with two weekly rehabilitation sessions, motor development over time was considerably worse in the twin in case 1 than in the other twin.


In the US, most people get healthcare through either private or government insurance, says Julie Rovner. When countries around the world are committing to universal health coverage, US politicians are as busy arguing about the balance between public and private approaches as they are debating the question of whether everyone should have access to healthcare


The physics of electron induced and photon induced reactions leading to potentially observable effects in astrophysical sites is reviewed. We consider in particular the cases (e/sup -/ or ..gamma..+/sup 12/C ..-->.. /sup 12/C, /sup 11/B*, /sup 11/B) for which the excitation functions are given.


(63) Continuation-in-part of application No. 08/721,197, filed on Sep. 27, 1996, now Pat. No. 5,756,635, which is a continu ation-in-part of application No. 08/427,652, filed on Apr. 21, 1995, now abandoned, which is a continuation-in-part of application No. 08/300,511, filed on Sep. 6, 1994, now abandoned, which is a continuation of application No. 07/991,942, filed on Dec. 17, 1992, now abandoned.


Background Bruton's Tyrosine Kinase (BTK) plays a critical role in chronic lymphocytic leukemia (CLL) cell survival by modulating B-cell receptor signaling. Ibrutinib (PCI-32765), a first-in-class oral inhibitor of BTK, inhibits proliferation, migration and adhesion in CLL cells. A total of 148 patients with CLL/SLL received ibrutinib monotherapy in a Phase 1 multiple ascending dose study (PCYC-04753) or Phase 1b/2 continuous dosing study (PCYC-1102-CA), after which a long-term extension study was available for continued follow-up for safety and efficacy with daily orally-administered ibrutinib monotherapy. The studies included patients with treatment-naive (TN) and relapsed or refractory (RR) CLL/SLL. The aims of the present analysis were to evaluate safety based on time on ibrutinib therapy (≤ 1 year and > 1 year), summarize safety findings in the TN and RR patient populations, and assess duration of response (DOR). Methods Demographics and baseline characteristics were summarized according to parent study, comprising either TN patients or RR CLL/SLL patients who had received at least one dose of ibrutinib monotherapy. Patient disposition, treatment-emergent adverse events (AEs), best response, overall response rate (ORR), and DOR were determined for the time treated (beginning in the parent studies and extending into the long-term extension study). Results At a median treatment duration of 21.5 months, 109 out of 148 patients continued treatment with ibrutinib for over a year. The percentage of patients who had a grade 3 or higher serious adverse event (SAE) declined over time from 43% within the first year of study treatment to 32% after the first year of treatment. With respect to side effects determined to be related to study drug, the number of grade 3 AEs and SAEs also declined from within the first year of treatment (24% and 8%, respectively) to after the first year of treatment (7% and 0%, respectively). AEs leading to ibrutinib discontinuation occurred in 12 patients within the first year of treatment for all 148 patients and in 6 out of 109 patients after the first year of treatment. Overall, the most frequent AEs grade 3 or higher were pneumonia (16.9%), hypertension (13.5%), neutropenia (11.5%), thrombocytopenia (7.4%), and diarrhea (5.4%), regardless of relationship to study drug. Grade 3 or higher SAEs were reported in RR patients at 62% compared to TN patients at 29%. Pneumonia was reported in TN patients at 6.5% and in RR patients at 19.7%. Within the efficacy population (n = 140), the ORR was 86.2% for TN patients and 88.3% for RR patients who achieved a partial response (PR) or better. The ORR combined with PR with lymphocytosis suggests that 93.1% of TN patients and 93.7% of RR patients achieved an objective response to ibrutinib therapy based on Cheson JCO 2012. After a median follow up of 27.2 months (range 1.9-42 months) for TN and RR responders who achieved PR or better, the median DOR has not been reached. At landmark 30 months, 76.1% of the responders were alive without progression. Conclusions Ibrutinib as a single agent demonstrates long-term safety, tolerability, and durability of response in patients with TN and RR CLL/SLL. Indeed, a decrease in the number of patients experiencing SAEs or AEs grade 3 or higher after 1 year of treatment with ibrutinib resulted in low rates of treatment-related discontinuation after that time point. Grade 3 or higher SAEs were reported at a two-fold higher rate in patients who had received prior therapies, which may be reflective of disease state rather than relationship to ibrutinib. A majority of patients remain on ibrutinib monotherapy with the median DOR not yet reached in the ongoing extension study. Disclosures: O9Brien: Pharmacyclics: Research Funding. Furman: Genentech: Consultancy, Speakers Bureau; GlaxoSmithKline: Consultancy, Speakers Bureau; Pharmacyclics: Consultancy; Gilead: Consultancy. Fowler: Pharmacyclics: Membership on an entity's Board of Directors or advisory committees, Research Funding. Coutre: Pharmacyclics: Consultancy, Research Funding. Burger: Pharmacyclics: Consultancy, Membership on an entity's Board of Directors or advisory committees. Jones: Pharmacyclics: Membership on an entity's Board of Directors or advisory committees, Research Funding. Wierda: Abbott Laboratories: Research Funding; Celgene: Consultancy, Membership on an entity's Board of Directors or advisory committees, Speakers Bureau; GlaxoSmithKline: Research Funding, Speakers Bureau; Genentech/Roche: Consultancy, DSMB, DSMB Other, Membership on an entity's Board of Directors or advisory committees, Speakers Bureau; Merck: Consultancy, Membership on an entity's Board of Directors or advisory committees; Sanofi-Aventis: Consultancy, Membership on an entity's Board of Directors or advisory committees; Tragara: Research Funding. Flinn: Pharmacyclics: Research Funding. Advani: Pharmacyclics: Research Funding; Janssen: Research Funding. Kolibaba: Pharmacyclics: Research Funding. Shaw: Pharmacyclics: Employment, Equity Ownership. Clow: Pharmacyclics: Employment, Equity Ownership. James: Pharmacyclics: Employment, Equity Ownership. Chu: Pharmacyclics: Employment, Equity Ownership. Byrd: Celgene: Consultancy; Johnson and Johnson: Consultancy; Pharmacyclics: Research Funding.


Introduction: The Republic of Moldova (Moldova) remains among the highest tuberculosis (TB) burden countries in the WHO European Region (1). The main intervention to improve TB diagnostics was the introduction of GeneXpert testing in 2012, which is a molecular investigation based on realtime polymerase chain reaction (PCR). While the efficacy of the GeneXpert test is evident, rifampicin-resistant cases identified by GeneXpert are not always confirmed by the culture method of laboratory diagnosis (phenotypic methods). We suspected that low MTB concentration can be a determining factor in discordant results. Objective: We aimed to determine the effect of low concentration of Mycobacterium tuberculosis (MTB) in sputum samples reported by GeneXpert on discordant results from GeneXpert and phenotypic drug susceptibility testing (pDST). Methods: We conducted a retrospective cohort study of the results of the samples from new TB patients who were examined and reported by the GeneXpert test in the Republic of Moldova between 2013 and 2017. The data were extracted from the National Database and the GeneXpert electronic database. Results: A comparison of GeneXpert and pDST test results in 2 810 analysed samples revealed 87 (3.1%) discordant rifampicin susceptibility results. Among the discordant results, 39 (55.2%) were detected as resistant by the GeneXpert test, but this resistance was not confirmed by pDST. Very low MTB concentration was identified in 16% (450/2 810) of the samples. Statistically significant dependence between low MTB concentrations and discordant results was not identified. Conclusion: The study showed that there is a divergence between DST results and GeneXpert results, which is not necessarily caused by low concentration of MTB. Additional studies are needed to identify factors associated with this divergence.


SUMMARY This study presents the results of a systematic evaluation of the implementation of the Bilingual Intercultural approach (EIB) in indigenous primary education and its impact on the quality of education, in the dimensions of equity, relevance, effectiveness and efficiency of education; in two indigenous regions of Mexico, with a comparative approach between the cases studied. The study is qualitative descriptive-explanatory section; the evaluation model CIPP (Context, Input, Process and Product) and Shinkfield Stufflebeam (1987) was applied. It also appealed to the school ethnography, for data collection techniques of participant observation (class sessions) focus group (teachers and parents), and semi-structured interview (managers and supervisors of each indigenous region). The results show that the EIB has had a limited impact on the quality of education; associated internal and external factors of each school and context; shape in the lack of effectiveness of the EIB in elementary school that significantly reduces the outcomes achieved by the indigenous teachers and education regarding bilingualism, multiculturalism and educational quality.


Research was conducted on a new formulation of 2,4-dichlorophenoxy-acetic acid (2,4-D). Unlike many of today's commercial products that contain ester or amine forms of 2,4-D, this new formulation contains the acid form of 2,4-D. Comparisons of this new formulation with amine and ester formulations include herbicide efficacy data, surfactant properties, and fertilizer compatibility.


Coding and testing schemes and the corresponding achievable type-II error exponents are presented for binary hypothesis testing over two-hop relay networks. The schemes are based on cascade source coding techniques and unanimous decision-forwarding, the latter meaning that a terminal decides on the null hypothesis only if all previous terminals have decided on the null hypothesis. If the observations at the transmitter, the relay, and the receiver form a Markov chain in this order, then, without loss in performance, the proposed cascade source code can be replaced by two independent point-to-point source codes, one for each hop. The decoupled scheme (combined with decision-forwarding) is shown to attain the optimal type-II error exponents for various instances of "testing against conditional independence." The same decoupling is shown to be optimal also for some instances of "testing against independence," when the observations at the transmitter, the receiver, and the relay form a Markov chain in this order and when the relay-to-receiver link is of sufficiently high rate. For completeness, this paper also presents an analysis of the Shimokawa–Han–Amari binning scheme for the point-to-point hypothesis testing setup.


Medical education is emerging with introduction and implementation of new teaching, learning and assessment methods. Medical education units in the academic institutions striving to motivate the students and to convert the learning into student centered from teacher centered. Open book test is an assessment method where the student is allowed to use the text book or notebook or any reference materials to write the examination. This will decrease the need for memorizing by the students and reduces the academic stress.1 Earlier studies reported that open book test is worth implementing as it is a best assessment tool and also promote student centered learning. Further, it helps to reduce the stress levels of the students.2 Open book test also motivates the student to use the textbooks more frequently and limits the last minute preparations for the examinations. Further, open book test improves the higher-order thinking skills of the students as they critically analyze the contents in the textbook also get adequate time to present those contents in a creative way in the examination.3 It was reported that there is no difference in the marks obtained by open book test and closed book test.4 As the main goal of the assessment is to assess the thinking skills rather memorizing skills. Further, the environment is relaxed to the students. As the open book test reduces examination stress without affecting the academic performance, it can be implemented in the medical education.5–7 Recently, All India council for technical education recommended open book test for engineering curriculum. However, the studies related to implementation of open book test are relatively less. Hence, the present study was undertaken to observe the effectiveness of open book test in reducing the pre-examination stress.


This paper introduces the features of plastering anhydrite. From base layer treatment, preparation of slurry, technical flow, operation methods and other aspects practical construction methods are presented in order to promote the application of plastering anhydrite.


To study the influence of different solution treatment on the metallographic structure variation and corrosion behavior of GH4698 in NaCl solution, the metallographic structure and corrosion characteristics of alloys which treated by forging and solution in NaCl solution with different concentrations have been discussed. The results show that there is dynamic recovery and re-crystallization characteristic in metallographic structure of GH4698 alloy after forging; after one time solid solution treatment, there are obviously grain growth characteristic and the second phase fully dissolved in the matrix and form the supersaturated solid solution; after two times solid solution treatment, there is precipitate and the growth of second-phase and carbide in sub-boundary. Indicate the corrosion rate by corrosion current density and find that the effect of solid solution on corrosion rate of GH4698 in NaCl solution. The corrosion rate of each specimen varies with fluctuation for the co-effect of factors or corrosion mechanisms. The alloy of forging, forging+ one time solution treatment and forging+ two times solution treatment shows their best corrosion resistance in 5.5%, 7.5% and 9.5% NaCl solution. Internal corrosion caused by second phase and carbide is obvious in 3.5% NaCl solution. Corrosion rate rising with the increasing of solution times in 5.5% and7.5% NaCl solution. However the corrosion rate decrease with the increasing of solution times in 9.5% NaCl solution. It is the combined action of factors and corrosion mechanisms.


There are 1.4 billion Android devices around the globe. With so many users and apps comes the question of privacy and security. Some permissions are critical to the operation of any app. A system is required which can tell whether an app X should be given a permission Y. Our basic idea is that an app belonging to a particular category should request permissions most common in that category. Around 130 users contributed to our dataset which had over 3964 records and 830 unique apps in 39 categories. A voting measure based on statistical mean value was used to decide the permissions to be given to particular app.


Dr. Laser has been doing laser procedures for more than a decade. He has a great reputation and thousands of happy patients. Two years ago he performed a laser procedure on a patient who unfortunately scarred afterward. The procedure was undertaken in the same manner as hundreds of other similar procedures performed by Dr. Laser. He also obtained a signed consent form from his patient warning her about the risk of scarring.


By analyzing the deficiency of the original k-means algorithm in intrusion detection,the k-means algorithm was optimized. The optimized algorithm was used in anomaly detection. Experiments show that the optimized algorithm can get better cluster result and progress was made in the rate of intrusion detection and anti-interference technique.


Nowadays, reliability assurance is crucial in components of IT infrastructures. Unavailability of any element or connection results in downtime and triggers monetary and performance casualties. Thus, reliability engineering has been a topic of investigation recently. The system logs become obligatory in IT infrastructure monitoring for failure detection, root cause analysis, and troubleshooting. This Systematic Literature Review (SLR) focuses on detailed analysis based on the various qualitative and performance merits of datasets used, technical approaches utilized, and automated tools developed. The full-text review was directed by Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) methodology. 102 articles were extracted from Scopus, IEEE Explore, WoS, and ACM for a thorough examination. Also, a few more supplementary articles were studied by applying Snowballing technique. The study emphasizes the use of system logs for anomaly or failure detection and prediction. The survey encapsulates the automated tools under various quality merit criteria. This SLR ascertained that machine learning and deep learning-based classification approaches employed on selected features enable enhanced performance than traditional rule-based and method-based approaches. Additionally, the paper discusses research gaps in the existing literature and provides future research directions. The primary intent of this SLR is to perceive and inspect various tools and techniques proposed to mitigate IT infrastructure downtime in the existing literature. This survey will encourage prospective researchers to understand the pros and cons of current methods and pick an excellent approach to solve their identified problems in the field of IT infrastructure.


When maintaining status-bridging friendships, people encounter inequalities in the context of their most intimate relationships. Using interview data on how people manage friendships with significantly poorer and richer friends in Hungary, this article explores lay discourses of inequality and justice, and the processes through which they lead to the decay (or the preservation) of income-bridging friendships at the micro level and to social segregation at the macro level. It shows, first, that different – egalitarian versus meritocratic – lay conceptions of inequality and justice translate into different everyday strategies of managing income-bridging friendships, focused on the hiding versus legitimization of inequalities, respectively. Second, it traces how both of these strategies, which are aimed at maintaining income-bridging friendships, eventually lead to their decay and to growing segregation between social classes.


Urban adaptation to climate change in Europe : Challenges and opportuinities for cities together with supportive national and European policies.


(1) Background: the community is the most basic place to maintain residents' lives, and therefore it is urgent to strengthen community resilience construction, which is directly related to the economic development, security and stability of urban communities. (2) Methods: this article combines the SWOT (Strengths, Weaknesses, Opportunities, Threats) qualitative analysis method and the AHP (Analytic hierarchy process) qualitative and quantitative analysis method to explore the current status of community emergency management in Xi'an City. A community emergency management evaluation model is constructed, which is based on six dimensions: infrastructure resilience, community organization resilience, risk hazard governance, emergency material security, emergency force construction, and emergency literacy. The evaluation index for community emergency management is established. Focusing on analyzing the strengths and weaknesses of communities in responding to sudden public health emergencies, opportunities and threats are identified. (3) Results: it was concluded that infrastructure resilience and emergency material support are community strengths, community organizational resilience is a community weakness, the emergency literacy dimension is a community opportunity, and risk and hazard management and emergency force construction are community threats. The results of the data research were further analyzed. (4) Conclusions: The final research results provide new theoretical support for community emergency management, while also providing theoretical and methodological references for emergency capacity evaluation in other fields.


Although sharks may attack man without warning, stingrays are docile, usually nonaggressive, and do not attack man unless disturbed, by coastal waders or divers or caught or netted by fishermen. Because stingrays are ubiquitous in all temperate and tropical oceans worldwide, and even occur in many tropical freshwater river systems, human stingray injuries are common but rarely fatal. In the United States alone, 750 to 2,000 stingray injuries are reported each year compared with more than 300 scorpionfish envenomings annually, many in home aquarists, and thousands of catfish‐inflicted spine injuries, most of which are not reported.1–6 On very rare occasions, stingrays have launched off surface waters and into anchored or speeding motorboats, inflicting fatal human injuries. Several fatalities from penetrating thoracic stingray injuries and septic stingray wounds have now been reported.1–4,7 Although not as common as injuries caused by other venomous fish, stingray injuries are an important group of, mostly preventable, marine envenomings.1–4

Since the 1950s, stingray injuries treated in emergency departments and/or reported to poison control centers have only been described retrospectively and, often, incompletely. To date, no prospective multicenter collaborative investigations by coastal medical centers have been conducted to verify the frequencies and fatal and nonfatal outcomes of stingray injuries. Nevertheless, as more vacationing travelers spend more leisure time exploring seacoasts and tropical reefs, often in isolated island areas without immediate access to advanced health care services, there will be greater potential for stingray injuries with poor outcomes. A retrospective meta‐analysis of the descriptive epidemiology of stingray injuries, the mechanisms of stingray envenoming, the multiple clinical presentations of stingray injuries, and the management strategies for stingray injuries is now indicated and may improve the clinician's ability to better manage and to prevent stingray injuries in travelers.

To describe the epidemiology, pathophysiology, presenting manifestations, and any …

Corresponding Author: James H. Diaz, MD, MPH&TM, DrPH, Program in Environmental and Occupational Health Sciences, Schools of Public Health and Medicine, Louisiana State University Health Sciences Center in New Orleans, 2021 Lakeshore Drive, Suite 200, New Orleans, LA 70122, USA. E‐mail: jdiaz{at}lsuhsc.edu


The article presents the results of research on the development of the design and testing for seismic resistance of the created prototype of the substructure (subsystem) of the hinged ventilated facade for buildings - the main bearing frame of these building products.


3'-Azido-2',3'-deoxythymidine and carbovir [racemic and (-) enantiomer] were evaluated individually and in combination for antiviral activity against human immunodeficiency virus type 1 replication and cytotoxicity in vitro. The combination of these drugs synergistically inhibited human immunodeficiency virus type 1 replication in C3 and Jurkat cells and in human peripheral blood mononuclear cells, although the same combination also produced synergistic cytotoxicity in human peripheral blood mononuclear cells.


A new isoaurone, 4,4'-dimethoxy-6-O-b -D-glucopyranosyl-isoaurone (1), were isolated from the tobacco stem. The structure of 1 was elucidated by spectroscopic methods including 1 D-and 2 D-NMR techniques. Compound 1 was also evaluated for its anti-tobacco mosaic virus (anti-TMV) activity and it showed high anti-tobacco mosaic virus activity with inhibition rate of 31.5 %. This valve is higher than that of positive control, ningnanmycin (28.4 %).


The prevalence of congenital hearing impairment (HI) is highest in Africa. Estimates evaluated genetic causes to account for 31% of HI cases in Africa, but the identification of associated causative genes mutations have been challenging. In this study, we reviewed the potential roles, in humans, of 38 novel genes identified in a murine study. We gathered information from various genomic annotation databases and performed functional enrichment analysis using online resources i.e. genemania and g.proflier. Results revealed that 27/38 genes are express mostly in the brain, suggesting additional cognitive roles. Indeed, HERC1- R3250X had been associated with intellectual disability in a Moroccan family. A homozygous 216-bp deletion in KLC2 was found in two siblings of Egyptian descent with spastic paraplegia. Up to 27/38 murine genes have link to at least a disease, and the commonest mode of inheritance is autosomal recessive (n=8). Network analysis indicates that 20 other genes have intermediate and biological links to the novel genes, suggesting their possible roles in HI. This study will contribute to advance our knowledge in unravelling the biological roles of novel murine HI genes in humans and could enhance the understanding of the genetic causes of HI in Africans.


ririHE WRITTEN PHASE of the case concerning the Delimitation of A the Maritime Boundary in the Gulf of Maine Area (Canada/ United States of America) (hereinafter called the Gulf of Maine case) was completed on December 12, 1983 with the filing of the third round of written pleadings by each party. The pleadings, consisting in each case of a Memorial (filed on September 27, 1982), a Counter-Memorial (filed on June 28, 1983), and a Reply (filed on December 12, 1983) are extensive. They contain an exhaustive analysis of both the facts of the dispute and the law of maritime boundary delimitation. The case will be of particular interest to international lawyers. It is the first case in which the chamber procedure of the International Court of Justice has been utilized, and it is the first occasion on which a tribunal has been asked to delimit a "single maritime boundary" that divides both shelf and water column. This is not simply of theoretical importance. As the Canadian Memorial


Astronomical, astrometric and geodetic observations by mm-Wave Very Long Baseline Interferometry (VLBI) are adversely affected by precipitable water vapour (PWV) in the troposphere. Current water vapour radiometers (WVRs), such as that deployed at the Large Millimeter Telescope (LMT) site, are difficult to install and maintain, and are prohibitively expensive for surveying promising new sites for telescopes or for wide-spread deployment for a priori calibration. We report here on initial progress towards a Planar Integrated Low-Cost H2O Atmospheric Radiometric Detector (PILCHARD), which aims to reduce the cost of 22 GHz WVRs for site surveys, whilst eliminating the need for moving antennas. It is found that the required tip curve can be generated by a static antenna using multiple pencil beams from a multi-feed, non-traditional offset reflector, while the necessary system receiver temperature is easily achievable using planar integrated off-the-shelf components alone.


This study is based on data collected at the Electronic Flight Bag (EFB) Advanced Software and Authorization Workshop for US operators currently involved in EFB software evaluation or implementation for their own fleets. With most US operators not taking delivery of new, larger aircraft in the next few years, they are considering ways of displaying near-term NextGen data on board existing aircraft through systems such as the EFB. The workshop collected operator near-term needs in the areas of EFB user interface and standardization and EFB advanced software applications. The analysis of the data collected during the workshop provided a prioritized list of operator needs over the next few years with an emphasis on runway safety and related NextGen systems. The study reports on those needs in the context of near-term NextGen systems and Class 2 EFBs.


Diabetic nephropathy (DN) is a major microvascular complication of diabetes involving oxidative stress and endothelial damage. Nitrosonifedipine (NO-NIF) is converted from nifedipine under the light illumination. The ability of NO-NIF to block calcium channels is quite weak compared with that of nifedipine. Recently, we have demonstrated that NO-NIF reacts with unsaturated fatty acid leading to generate NO-NIF radical, which acquires radical scavenging activity. Also we have reported that NO-NIF reduces cytotoxicity of tumor necrosis factor-α (TNF-α) in cultured human glomerular endothelial cells. However, it is unclear the effects of NO-NIF on the pathogenesis related with oxidative stress, such as DN. In this study, we investigated whether NO-NIF treatment improves DN by using KKAy mice developing type II diabetes. Urinary albumin (UA) and total urinary protein (TUP) were elevated in KKAy mice (16 weeks old) compared with C57BL/6 mice, which were significantly decreased by NO-NIF treatment (30 mg/kg/day, i.p., 4 weeks) (UA; 1415.2 ± 312.5 vs 609.6 ± 151.5 μg/24hr, p


The Nimes-Courbessac (1949-1992) 12 hrs. resolution rainfall database exhibits a multifractal behaviour for periods of time of at least 12 hrs. to about 16 days. Using the Double Trace Moment data analysis technique, we estimated the basic multifractal indices α≃0.45±0.05 and C 1 ≃0.60±0.02, which characterize the process in the framework of universal multifractals. The probability distribution of large fluctuations has a hyperbolic fall-off


In this paper is presented a solution that aims to solve by new technologies, the security issues of railway infrastructure and security perimeters and adjacent rail traffic. Aim pursued to achieve this technical solution for monitoring has two components: securing railway traffic by preventing accidents involving fatalities or major property damage and preventing and combating anti-social acts affecting railway infrastructure operators and the quality of rail services. The system of monitoring and analyzing computer security camera image transmitted on each route covered and determine whether there are threats to safety. When determining the occurrence of sufficient evidence to trigger a control procedure, the responsible persons (ie driver and dispatcher control center) will be notified of upcoming imminent risk factor, through video, audio and written.


This study evaluated Wood–Based Activated Carbon Fibers Paperboard (WACFP) made of different proportions of wood–based activated carbon fibers (WACFs) with wood pulp as the oil fume absorbing material. The WACFPs, in basis weights of 180 g/m 2 and with 0, 10, and 40% WACFs, absorbed peanut oil fume at the smoke point, absorption saturation was reached at 80, 110, and 120 min, and oil fume absorp- tion was 0.0203–0.0304 g/cm 2 . The WACFPs, in basis weights of 360 g/m 2 and with 0, 10, and 40% WACFs, reached absorption saturation at 210, 250, and 260 min, and oil fume absorption was 0.0424–0.0604 g/cm 2 . For Ames test, the oil fume absorbed by WACFPs extracted by methanol at concentrations higher than 0.10 mg/plate had cytotoxicity with Salmonella typhimurium TA98 ( ± S9) and TA100 ( ± S9); and the Mutagenicity ratio of methanol oil fume extracts at concentration of 0.05 mg/plate for Salmonella typh- imurium TA98 ( ± S9) and TA100 ( ± S9) were higher than 2, representing very high mutagenicity for Salmonella typhimurium TA98 and TA100. According to the GC–MS analysis of the n–hexane soluble fraction of oil fume, the trans–trans–2,4–decadienal (t–t–2,4–DDE) was the main mutagenic compound of peanut oil fume probably.


Hyperpigmentation is a common concern of patients in dermatology clinics. Although there are many treatment options, lasers are considered a promising therapy for various hyperpigmentary conditions.


Estimates are that almost half of the world's population has an active
primary headache disorder, i.e. with no illness as an underlying cause. These
can start manifesting in early adulthood and can last until the rest of the sufferer's
life. Most specialists concur that sudden changes in daily lifestyle, such are
sleep rhythm, nutrition behavior or stress experience, can be valid triggers for
headache sufferers. Health care professionals recommend leading a diary to
self-monitor personal headache triggers in order to learn to avoid headache attacks.
However, making sense out of this data is difficult. Despite existing
smartphone approaches in literature that have evaluated behavior change support
systems for headaches, they have failed to provide appropriate feedback on
the collected daily data to showcase what causes or prevents an individual's
headache attacks. In this paper, we present HeadacheCoach, a smartphone app
that tracks headache-triggering lifestyle data and headache attacks on a daily
basis and propose a mixed-method approach to examine which feedback method(
s) can strive the behavior change most in order to prevent future headache
attacks.


inforced through the use of ritual ecology and ENSO events for major sacrificial moments. What was the purpose of such sacrificial events? Were they conducted in times of stress (caused by severe weather events) to appeal to some higher power, or possibly these weather events were utilized to reinforce the power and structure of the elite? The purposefully built architecture for ritual and sacrificial events in association with elaborately constructed iconography displaying images of sacrifice suggest that these events were carefully planned. It is unclear how the ENSO events factored in, but it is likely that they were a part of this purposefully conceived plan as well. Bourget ends his book returning to a common question for Moche scholars in recent years: what was the role of sacrifice in the Moche social structure and ideology? Two main schools of thought regarding this issue have arisen: those who argue that the sacrificial remains were from individuals of higher status, captured in ritual battles, and those who think the sacrificed individuals were captured during normative battles between competing groups or polities. Moche battle scenes do not often show Moche warriors fighting other groups, and they do not show grand celebrations of victories of other groups. Bourget claims that they most often depict a number of individuals clad in warrior costumes, battling others dressed in a similar fashion. Bourget presents two possible conclusions based on the archaeological and symbolic information: (1) the Moche would obtain their captives from regular combat with possibly nearby enemies, other Moche groups, or foreign groups; and (2) the Moche would obtain sacrificial victims through a selection process that may have included ritualized battles. In this powerful and extensive book, Bourget does an excellent job of using multiple lines of evidence to assess the roles played by violence and ritual ecology within the larger Moche social and ideological system, as exemplified in the excavations at Huaca de la Luna. Furthermore, Bourget details how the Moche rulers and elite could have used ENSO events to promote a type of ritual ecology that would further reinforce their power as well as the larger Moche ideological system that promoted the necessity of ritual battle and sacrifice. Although the nature of excavations and resulting conclusions from such a massive and important temple structure would naturally yield information regarding elite and ritual acts, it would be interesting to build on this work with more information regarding the role played by common people within this larger ideological system.


Background: Pseudotumor cerebri syndrome (PTCS) encompasses a variable combination of signs and symptoms of raised intracranial pressure without a brain tumor or space occupying lesion. The lack of continuous pancephalic/retro-orbital headache or pulsating tinnitus is a well-documented observation. Cases' presentation: We report on 3 non-obese women who presented with progressive visual loss. All of them stated that their headache was mild, nonsignificant, intermittent, or migraine-like which did resolve spontaneously or after the use of oral paracetamol. Nausea and/or vomiting were present. Variable degrees of reduction in the visual acuity, enlargement of the physiological blond spot, peripheral visual field constriction, papilloedema, and secondary optic atrophy were found. Their CSF opening pressure was 42, 37, and 39 cm H2O respectively; other CSF parameters were normal. Their diagnosis was primary PTCS. Conclusion: PTCS remains a diagnostic challenge. The lack of significant headache (and obesity) contributed to the delayed diagnosis with resultant visual loss.


Abstract: The usefulness and the problems of endoscopic ultrasonograpy (EUS) in the diagnosis of submucosal tumors (SMT) of the upper alimentary tract were evaluated in this study. EUS was carried out in 86 cases with SMT of the stomach. Tumors of 13 cases was confirmed histologically (leiomyoma in 7 cases, leiomyosarcoma in one, lipoma in 2, gastric cyst in one, aberrant pancreas in one and Schwannoma in one case). In only one out of 22 cases with SMT of the esophagus, the tumor was surgically resected and a pathological examination revealed leiomyoma


This study investigated the steady two-phase flow of a nanofluid in a permeable duct with thermal radiation, a magnetic field, and external forces. The basic continuity and momentum equations were considered along with the Buongiorno model to formulate the governing mathematical model of the problem. Furthermore, the intelligent computational strength of artificial neural networks (ANNs) was utilized to construct the approximate solution for the problem. The unsupervised objective functions of the governing equations in terms of mean square error were optimized by hybridizing the global search ability of an arithmetic optimization algorithm (AOA) with the local search capability of an interior point algorithm (IPA). The proposed ANN-AOA-IPA technique was implemented to study the effect of variations in the thermophoretic parameter (Nt), Hartmann number (Ha), Brownian (Nb) and radiation (Rd) motion parameters, Eckert number (Ec), Reynolds number (Re) and Schmidt number (Sc) on the velocity profile, thermal profile, Nusselt number and skin friction coefficient of the nanofluid. The results obtained by the designed metaheuristic algorithm were compared with the numerical solutions obtained by the Runge–Kutta method of order 4 (RK-4) and machine learning algorithms based on a nonlinear autoregressive network with exogenous inputs (NARX) and backpropagated Levenberg–Marquardt algorithm. The mean percentage errors in approximate solutions obtained by ANN-AOA-IPA are around 10−6 to 10−7. The graphical analysis illustrates that the velocity, temperature, and concentration profiles of the nanofluid increase with an increase in the suction parameter, Eckert number and Schmidt number, respectively. Solutions and the results of performance indicators such as mean absolute deviation, Theil's inequality coefficient and error in Nash–Sutcliffe efficiency further validate the proposed algorithm's utility and efficiency.


A temporary cover for excavations comprising a platform having a lowermost surface for contact with the ground surrounding the excavation and an uppermost surface and means attached to the platform for securing the platform to a below ground anchor point.


An electrochemically integrated multi‐electrode array namely the wire beam electrode (WBE) and noise signatures analysis have been applied in novel combinations to study crevice corrosion behaviour in the presence of pits. Characteristic electrochemical noise signatures were found to correlate with characteristic changes in WBE current distribution maps, which indicate corrosion rates distributions, corrosion patterns and the degree of pitting and crevice corrosion. Specifically, two characteristic noise patterns were observed: (i) the characteristic noise pattern of quick potential changes towards more negative direction with no recovery (termed noise signature I) was found to correspond with the initiation and stabilization of the anode inside crevice; and (ii) the characteristic noise pattern of the cyclic potential oscillation at a constant frequency (termed noise signature II) was found to correspond with the stable anodic dissolution in the occluded cavity site in WBE current distribution maps. A new parameter namely the localization parameter (LP) has been proposed to describe the degree of localization. The LP for crevice corrosion was found to be low compared to that for pitting corrosion.


Under mild and neutral free radical conditions, an α,β-unsaturated ketone reacted with tributyltin hydride to produce an intermediate resonance-stabilized allylic O-stannyl ketyl. Upon subsequent hydrogen atom abstraction, a tin(IV) enolate was afforded which could be quenched with a variety of electrophiles and form new carbon−carbon bonds. Aldehydes react to produce aldol-type products and both intramolecular and intermolecular carbonyl addition reactions were investigated using this strategy. Using similar methodology, the tin(IV) enolate could be quenched in the presence of HMPA with various alkyl halides and α,β-unsaturated carbonyl compounds (Michael acceptors) to yield alkylated products in good yields. These reactions represent a very mild regioselective alternative to metal enolate formation which usually requires strong bases such as LDA or strongly reductive dissolving metal conditions to achieve success. New carbon skeletons for natural product synthesis can be readily constructed using this c...


Objective:To establish an HPLC method for determination of ziprasidone(Zip)in human plasma.Meth- ods:The compounds were separated on a Hypersil C_(18)column(200 mm×5.0 mm,5μm).The mobile phase was a mixture of methanol-0.05 mol·mL~(-1)KH_2PO_4 in a ratio of 70:30(adjusted pH to 6.0±0.1 by H_3PO_4),the flow rate was 1.4 mL·min~(-1).The column temperature was 35℃.The detection wavelength was UV 229 nm.Results: A good linearity was obtained from 0.0169-1.62μg·mL~(-1)in plasma(r=0.9994).The lowest concentration de- tected was 0.0169 μg·mL~(-1).The average recovery of method was(103.66±4.19)%(n=15).The within-day and between-day RSD were ≤6.8% and ≤7.4%,respectively.Conclusion:The mrthod is simple,quick,sensi- tive,a good recovery,and accurate and can be used for clinical pharmacokinetic study of ziprasidone.


BACKGROUND: We evaluated the efficacy of a single-injection technique for percutaneous peribulbar anesthesia with a short needle as an alternative to the double-injection technique for cataract extraction. METHODS: We included 200 patients who underwent elective cataract surgery randomized into 2 equal groups. They received either single-injection peribulbar anesthesia with a 16-mm needle or double-injection peribulbar anesthesia with a 25-mm needle. RESULTS: Both techniques provided comparable akinesia. A similar number of patients in each group required supplementary injection. The total volume of local anesthetic used was less in the single-injection group. There were no serious complications in the 2 groups. CONCLUSION: The single-injection technique for percutaneous peribulbar anesthesia with a short needle is a suitable alternative to the double-injection technique for cataract surgery.


This paper assesses critically recent proposals for tax reform of superannuation in Australia against criteria of efficiency, equity, administrative complexity and revenue impact. The main conclusion reached is to support the general thrust of reform, including the removal of multi-stage taxation. But this support is qualified by the need to provide quantified analysis of the long-run fiscal costs of reforms relative to both the present system and that projected under unchanged policies.


Yorkshire Cancer Research will invest £5 million in research that will have a direct impact on cancer patients in Yorkshire, it has been announced ...


derived from their dependency on him; they said they wanted to reach out to the peasantry, where in fact they wanted to reach down. I would cavil with Otto's conclusion that Sytin's association with Posrednik was a high-water mark in his publishing career; the year he broke with Gorbunov his newspaper, Russkoe slovo, became the empire's largest and within a decade Sytin was producing one-fourth of all books in Russia. The most interesting chapter of this informative study, an analysis of some of the books produced by the firm, is in certain respects also the least satisfying. Having argued that Posrednik was "democratic in conception," Otto then produces a myriad of examples to illustrate how heavy a hand of didactism was laid on Posrednik's texts. A more fruitful approach to this content analysis might have asked specifically what the intelligentsia, especially Chertkov, were hoping to accomplish by supplying the rural peasantry with stocks of tales about the horrors of urban life and the search for happiness in self-sacrifice and rejection of worldly possessions. Many stories produced for Posrednik read not unlike those distributed by its erstwhile enemy, the Orthodox church. Hopefully, the caution characteristic of a dissertation will be released in a fuller manuscript treatment of this engaging subject.


The present invention relates to a refrigeration apparatus, in particular household refrigeration apparatus which comprises a storage compartment enclosing (5) of the housing (1, 2) and can be mounted within the container (5) in the storage compartment (7). The drawer comprises a receptacle (14) and a cover (15), which can be adjustable in height between the drawer (14) in a closed position and an open position.


. Phishing detection is mostly performed through the usage of blacklists. However, blacklists cannot be exhaustive and lack the ability to detect newly generated phishing URLs. In recent years, increased attention has been given to exploring machine learning techniques in order to improve the universality of phishing URL detectors. This article aims at presenting our results on phishing URLs classification where three different features: lexical features, character level embeddings, and word level embeddings were compared with the view to find an approach that maximizes the ratio of phishing URL detection. In addition, a new deep neural network architecture for that problem was suggested. The said deep neural network consists of combined multiple CNN and LSTM layers. The 94.4% accuracy was achieved by combining character and word level embeddings.


Although the idea of Liangji Hong of the population lack any trace of the traditional Chinese idea of population,but living in the Qianlong,Jiaqing stable and peaceful years;noted that the problem of rapid population growth and noted that the rate of population growth and housing,land and so the relationship between the increase of social wealth,and the consequences of rapid population growth;to put forward the "jun-phase swap method" and other measures to solve the population problem,the strategy we either ran today,be learned.Thus,the population in modern China,he thought,should be a place.In this paper,the population from the Liangji Hong thoughts and ideas of ancient Chinese population,the relationship between population growth and the relationships between the population growth and economic,to solve the population problems and their practical significance elaborate.


Including dynamic aspects in the environmental assessment of power systems allows computing the environmental benefits of demand-side management strategies for the smart grid which could not be assessed with static data such as shifting part of the demand from one period to another. Several methodological approaches have been developed in life cycle assessment to account for dynamic aspects, but none has given much attention to the demand side of the equation. However, demand is also prone to fluctuate in time and its misrepresentation may lead to additional errors. In this study, a stochastic approach was applied to model the fluctuating residential power demand of Canadians' homes. An hourly and a yearly average electricity mix were then used to compute the environmental impacts of the hourly or yearly average homes' electricity demand. Finally, an approach combining an average and a marginal hourly electricity mix was then proposed to assess the benefits of a simple demand side management strategy: the shifting of homes' dryers loads up to two hours later than usual. Results show that assuming a constant demand or electricity mix both leads to errors which may be as high as 150% depending on the period of the month assessed. Moreover, using an hourly average electricity mix to set up the demand side strategy increases climate change impact by 0.6% whereas using a marginal mix decreases climate change impact by 10%.


The paper analyzes different discourses that, at present, are being used when talking about religion in the public sphere. It shall not discuss religion or religions, but the way in which these themes are perceived and discussed in Western public opinion, particularly in Europe, since this debate can be relevant for the discussion on the role of religion in Brazilian society. The paper shall analyze three discourses, which shall be called respectively (1) "cultural determinism", (2) "selective anti-religiosity" and (3) "State laicism". It aims at pointing out the logical and categorical mistakes and the incoherencies in these discourses, which dominate the present debate on the role of religion in general and of Islam in particular in Western societies. Key-words: Religion. Secular State. Religious Intolerance. State Neutrality.


Education is the basic requirement for Human Development. With education, employment opportunities are broadened and income levels are increased. The development of an individual and the progress of a nation depend on education. The present article tried to understand the differentials and factors associated with Rural Dropouts in High School level. Thepresent study investigates the factors influencing the ruraldropouts in High School level in Sivaganga District of Tamilnadu. Based on the responses of 20 rural dropouts selected through random sampling. The major factors influencing school dropouts were found to be household work, lack of parental guidance in studies, large family size and poor economic condition of the family, failure in examination, lack of time for study, punishment by teachers and lack of interest in studies.


This work is motivated by the success of the anisotropic adaptive finite element methods in accurately simulating complex physical systems in science and engineering. The parallel implementation of anisotropic adaptive finite element methods is a challenging task for which load imbalance continue to be a significant bottleneck in the global simulation efficiency. We have developed and optimized in the last years, tools and algorithms to manage efficiently the dynamic load balancing in the framework of parallel anisotropic mesh adaptation [1-4]. However, there still complicated and challenging to predict a quantified estimation of parallel workload of adaptive finite element meshes. Indeed, the mesh adaptation procedure changes dynamically the size of the mesh over all the processes. This mechanism is managed by an anisotropic error estimator that allows to equi-distribute the error over the entire domain by refining and coarsening the mesh in the regions where it is needed [5-7]. In other words, the size of the problem changes permanently along the runtime execution. The leading questions that arise from this analysis are: how to derive a scalability model to measure the parallel efficiency of a dynamic adaptive simulation? And how to estimate quantitatively the workload needed to achieve the remeshing stage? We propose in this paper, an anisotropic a posteriori error estimator that controls the error due to mesh discretization in all space directions. From the a posteriori error analysis, we get an optimal metric (optimal mesh) as a minimum of an error estimator function constrained by a given number of elements. The optimal metric obtained is used to build an optimal mesh for the given number of elements and also to derive a quantitative estimation of the work that will be done in the remeshing stage. We conduct performance analysis over different multi-phase flows [8] to highlight effectiveness of the proposed approach.


Background: B type natriuretic peptide (BNP) and its precursor, the inactive form of NT-pro-BNP, are currently themost studied laboratory parameters in the heart disease spectrum. The assessment of their blood concentrationsprovides valuable information on the severity and prognosis of the disease.Aim: to evaluate plasma B-type natriuretic peptide levels in paediatric patients with congenital heart disease and toasses its value as diagonstic and prgnostic marker.Patients and methods:This is a cross-sectional, case-control, hospital based study carried out on 31 pediatric cardiacpatients enrolled from NICU and pediatric department of Qena university hospital between August 2017 andNovember 2018. Additionally, 30 healthy age and sex-matched were used as controls. Echocardiography has beenperformed to all included children, in addition to plasma BNP measurments using ELISA kit.Result(s): Overall results showed that the frequency of multiple congenital anomalies was 38.7%, followed byisolated VSD (25.8%), while isolated PDA has the least frequency (6.5%). There was significantly higher meanplasma BNP levels among pediatric patients with CHD versus the controls (19.36 ± 19.73, 2.99±1.25 respectively,p<0.05 ).Conclusion: These results suggest the possible role of plasma BNP as a significant marker in diagnosing pediatricpatients with CHD.


Objective The purpose of this experiment was to study the limiting factors on photosynthesis in Coptis chinensis leaves,which could provide a theoretical basis for its planting under drought condition.Methods Four groups of drought conditions,control(CK,normal moisture content),light drought(LD),moderate drought(MD),and heavy drought(HD),were set in the experiment through measuring the relative moisture content of soil.The rapid light response curves,stoma conductance(Cond),transpiration rate(Tr),and intercellular CO2(Ci) in the leaves of C.chinensis under different degrees of short-term drought were determined.Results With the increase of photosynthetically active radiation(PAR),the declined range of Fm'and rised range of qN in the LD,MD,and HD groups were less than those in CK group.Moreover,the lowest declined range of Fm' in the HD group was about 54.2% and the lowest value of qN was 0.595.On the contrary,the rised range of Ft and declined range of qN and φPSII in the LD,MD,and HD groups were higher than those in CK group.Furthermore,the values of Cond and Tr in CK group were higher than those in LD and MD groups,but the values of Cond,Tr,and Ci in CK group were lower than those in HD group.Conclusion The decrease of photosynthesis is mainly due to non-stoma under the short-term HD stress(PSII reaction centre becomes inactive,the ability of heat dissipation decreases,and photosynthetic electron transport rate decreases),while the limiting factors for photosynthesis of C.chinensis leaves are due to the stoma and non-stoma combined restriction under the short-term LD and MD stresses.


Tissues from 17 patients with malignant lymphoma (5 cases of the nasal cavity and paranasal sinuses, 10 cases of the tonsil and 1 case of cervical lymph node), and 1 caes of plasmacytoma of the paranasal sinus, were observed under the electron microscope. Findings were compared with those seen under light microscopy.On the basis of histologic morphology, malignant lymphoma may be classified in a variety of ways. Commonly, this tumor is classified: Reticulum cell sarcoma, Lymphosarcoma and Hodgkin's disease. Histologic classification of 17 cases was composed of tissues from 13 patients with reticulum cell sarcoma, 2 lymphosarcoma, 1 Hodgkin's disease and 1 plasmacytoma. However, this tumor shows a widely varying range of morphology. This variation sometimes makes it difficult to differentiate the types.Ultrastructurally, reticulum cell sarcoma was classified into three types (undifferentiated, poorly differentiated and well differentiated).Ultrastructurally, lymphosarcoma was classified into two types (poorly and well differentiated).It was revealed by ultrastructural findings that five cases of lymphosarcoma and three cases of plasmacytoma were confused with reticulum cell sarcoma.Consequently, thorough electron microscopic observations should be made in order to better understand and diagnose correctly patients with malignant lymphoma.