Previously, a new mathematical model based on the 'tension center' or 'strain nucleus' concept was proposed by the author for the response characterizing flow in a confined aquifer undergoing three-dimensional consolidation. The new approach differs from Bio's [1941] in that it leads to the development of a unique integrodifferential equation for the pressure head decline occurring within the porous system. The consideration of the horizontal strain components results in a conceptually simple modification of the classical diffusion equation to which a further integrodifferential term accounting for the three-dimensional effect is added. In the present paper the new equation of flow is solved in a pumped artesian aquifer enclosed in a half space by an iterative finite element technique. It is shown that in shallow and relatively thick units (with W ≃ 0.5, where W is the ratio between the average depth and the thickness of the aquifer), downward vertical components of flow develop and that the average drawdown deviates moderately from the Theis solution and is no longer uniquely represented against the dimensionless time. The three-dimensional effect produces an additional soil compression which retards the piezometric decline. At large values of time the horizontal strain components vanish, the diffusion equation holds, and the solution becomes parallel to the Theis profile. As a major consequence the traditional aquifer tests can still be applied to assess the formation permeability, but they yield a 40% overestimate of the elastic storage coefficient. In deeper units (W > 0.5) the importance of the three-dimensional effect diminishes, is already small when W = 1, and becomes negligible for W ≥ 2. In this case the diffusion equation and its solutions are sufficiently accurate. From a practical standpoint the quantitative results given herein are limited by the condition that a mechanically homogeneous and isotropic half space is required.


The paper presents the studies realised on the "Portici" Houses, a part of the historic Centre of Bolzano, built at the end of the 12th century. This characteristic architectural typology is composed by a system of houses with narrow facades and a continuous arcade on the front. The serial repetition of this type of building forms a constant structure, interrupted only by a system of atria that provide daylight and fresh air to the dwellings. The surface-to-volume ratio, the dimensions of the courtyards, the presence of internal shadowing, the thermal inertia of walls and cellars, and the colour of the surface finishing have a positive influence on heating and cooling demand of the buildings. Unfortunately, more recently, the users have altered the historic energy system with roofs and
canopies to improve comfort and to protect from sun and water. This situation has completely changed the original energy and environmental behaviour. The study aims to restore the original concept and to adapt it to the modern requirements, both optimizing
energy efficiency and preserving the heritage values. This means to recognize historical transformations, users' needs, present uses, critical points, and opportunities for the retrofit. The deeper knowledge is the starting point for defining the more appropriate retrofit actions, which include suitable technologies and systems, which are cost-effective, technically and aesthetically compatible with the value of buildings and urban settlement.


Saigon-Ho Chi Minh City (HCMC) is a typical 21st-century mega-city coping with informal hyper-growth. Government planners are under pressure to provide mass housing, transit and utilities. Yet HCMC has developed a distinctive and effective homegrown informal housing system based on 'tube housing'. This system of dense housing, motorcycle transport and laneways embodies an integrated everyday urban culture whereby each of its purposes (work, commerce, rest and recreation) in turn shapes the whole urban form. As such, it is argued that these everyday forms of urbanism should be respected and incorporated by city planners into their masterplans rather than be viewed as anachronistic, illegal forms to be overcome and deconstructed.


Abstract The calculation of a two-cascade optical system containing two computer generated optical elements (CGOEs): focusator and compensator, has been carried out. The smooth phase transfer functions of CGOEs, ensuring the wavefront forming of a given form and with demanded spatial intensity distribution along its surface, has been derived by ray-tracing.


A SURGICAL MICROSCOPE COMBINED INTERNALLY WITH OFTALMOLOGICO APPARATUS optical coherence tomography ( "OCT"), IN WHICH PROVIDES LEADING AUTOFOCUS a focusing lens MOTORIZED MICROSCOPE SURGICAL INTERNAL OFTALMOLOGICO WITH A SIGNAL OUTPUT DEVICE FROM OCT. A SURGICAL MICROSCOPE OFTALMOLOGICO INCORPORATION INCLUDES: (A) APPARATUS optical coherence tomography ( "OCT"), (B) A beam combiner UNION FOR DOMESTIC OUTPUT FROM THE MICROSCOPE SURGICAL EQUIPMENT OCT OFTALMOLOGICO; And (c) a motor for moving a focusing lens OFTALMOLOGICO INTERNAL SURGICAL MICROSCOPE IN RESPONSE TO A SIGN OF THE APPARATUS OCT AUTOENFOCANDOSE THUS THE SURGICAL MICROSCOPE OFTALMOLOGICO.


Contrary to a once-popular belief, the Great Black Migration from the South tended to be selective of those blacks who had relatively high levels of education, occupational skills, or other forms of human capital. The present study analyzes the extent to which this selective out-migration depleted the South of an important human resource: blacks who became eminent entrepreneurs. Data on southern-born blacks who became prominent business owners in other regions of the nation indicate that the heaviest losses of these blacks were suffered by places in the Upper South that border northern states and by places in the Deep South with negligible urban black populations. It is suggested that these findings can be explained by basic concepts of migration theory and research, such as push and pull factors, intervening obstacles, and the presence or absence of community attachments.


Ecstasy use is potentially damaging to health [20; 36; 37] yet prevalent [38; 39]. Legislative changes have not been effective in discouraging ecstasy use, and the development of theory-based behavioural interventions is warranted because these have been successful in generating behaviour change in other areas [40; 41]. Behaviour change interventions are more likely to be effective if they target modifiable antecedents of the target behaviour. For example, if expected positive outcomes of a target behaviour differentiate between those who do and do not engage in that behaviour, it is prudent to target outcome expectancies in behaviour change interventions [2]. Which potentially modifiable cognitive antecedents of ecstasy use should interventions target? Unfortunately, although ecstasy was synthesized in 1912 [3], and ecstasy use has been studied for 20 years (e.g. [42; 43]), there is no systematic review of this research identifying potentially modifiable cognitive antecedents of use. We aimed to summarize research to date, synthesizing quantitatively all published, quantitative studies of psychological determinants of ecstasy use among young persons living in Western society.


Aim To enhance the quantity of tourism industry.Methods By Abstracting to analyse elements appeared in the competition of the modern tourism.Results The competition of the modern tourism industry has changed from that among companies to that among government,company and community,which let all people involved.Conclusion The reason can be the following three,firstly,the government plays the apparent role and realizes the function of tourism industry to enhance the city′s image.Secondly,the company should care about the social power and the mass′s special need.Thirdly,in order to protect the interest,the investor image has been set up.Owing to this change,there will be new elements in the competition of tourism industry,thus,Abstracting the new element is important to enhance the quality of tourism industry,which becomes our key point.


Objective: The aim of this study was to determine the levels of serum pro-brain natriuretic peptide (pro-BNP) and interleukin (IL)-6 in patients with stable chronic obstructive pulmonary disease (COPD) and to correlate these markers with health-related quality of life using the COPD assessment test (CAT). Materials and Methods: Serum pro-BNP and IL-6 levels were measured in 82 patients with stable COPD. Serum pro-BNP and serum IL-6 levels, pulmonary function, and oxygen saturation (SpO2) were measured according to the Global Initiative for Chronic Obstructive Lung Disease (GOLD) stage and CAT score. Also, the associations of both pro-BNP and IL-6 with the clinical parameters of patients were tested. Results: The serum levels of IL-6 (7.57 [5-11.16] pg/mL) and pro-BNP (120.55 [92.89-144.20] pg/mL) were higher with enhancing disease severity based on the GOLD classification (p = 0.034 and 0.068, respectively). Also, serum levels of pro-BNP (120.55 [89.50-147.90] pg/mL) and IL-6 (6.68 [4.40-11.97] pg/mL) were increased in patients with high CAT scores (p = 0.004 and 0.017, respectively). There was a significant positive correlation between plasma pro-BNP and IL-6 levels (r = 0.332, p = 0.002). Conclusion: The results demonstrated that with increased severity of obstruction based on the GOLD criteria both IL-6 and pro-BNP were elevated. This increase in inflammatory markers was associated with a reduced quality of life and the severity of hypoxia. These findings indicated that lowering IL-6 and pro-BNP could be useful in the management of COPD patients.


In this thesis, an extended Kalman filter formulation for attitude estimation using inertial sensors is developed for implementation in a small satellite simulator. Two different attitude parametri ...


The Italian playwright Dario Fo has attracted attention recently from major theatre journals and from American and British audiences. He is recognized as a supremely talented comic performer, master of improvisation in the manner of the commedia dell' arte, and a dedicated if unorthodox political artist, head of an innovative theatre commune in his native Milan. Formal discussion of his theatre pieces as drama , however, has hardly begun. There are several reasons for this state of affairs: a) low-comic forms generally receive less critical attention than other kinds; b) much of Fo's work is deliberately topical, with few established texts; c) Fo's political "message" and the question of its effectiveness tend to monopolize attention.This paper will attempt to make a clear-cut beginning in the direction of considering Fo' s pieces as drama. It will take one of his best-known works, Non si pogo! Non si pogo! (We Won't Pay! We Won't Pay!) , I examine the particular way it works , establish its integrity as ...


In this paper, we provide a high signal-to-noise ratio (SNR) error rate analysis of amplify-and-forward (AF) best relay selection in networks impaired by Rayleigh fading and generic, possibly non-Gaussian noise. The derived closed - form asymptotic error rate expressions are applicable to any type of noise with finite moments. Exploiting these analytical results, we formulate a power allocation problem with energy consumption fairness constraints for the source and the relays, which is solved using monomial fitting and a series of geometric programs. The accuracy of the derived analytical results and the effectiveness of the proposed power allocation scheme are confirmed with computer simulations.


Among the technologies for remediation of contaminated soils, the phytoremediation is a feasible approach. The first step towards to the implementation of this strategy is the selection of plants with potential to be used in areas that need remediation. The aim of this study was to evaluate the potential for phytoextraction of copper (Cu) by sorghum (Sorghum bicolor), pearl millet (Pennisetum glaucum), crotalaria (Crotalaria juncea) and jack beans (Canavalia ensiformis). The experi- mental design was in randomized blocks, and treatments consisted of 0.8, 3.9, 19.7 and 98.4 µmol L -1 of Cu in the nutrient solution. Thirty days after the beginning of the treatments, the leaf gas exchange was measured in mature leaves. Then, the plants were harvested, separated into shoot and root system for determining dry matter and Cu accumulation. The treatment with 98.4 µmol L -1 of Cu markedly impaired shoot and root growth. Stomatal conductance, leaf transpiration rate and net CO 2 assimilation were not affected until the treatment with 19.7 µmol L -1 of Cu in the nutrient solution. Cu content and accumulation in plant tissues were well related to the metal concentration in the nutrient solution, with higher values in the roots than shoots. Although the preferential accumulation of Cu in the roots and reduced transport to the shoot contribute to enhance plant tolerance to this metal, it limits the use for Cu phytoextraction. Jack bean had the great- est Cu concentration, accumulation and transport of Cu to the shoot. Thus, this plant species has potential to be employed in programs of Cu phytoremediation.


Milk whey processing wastewaters (MWPWs) are characterized by high COD and organic nitrogen content; the concentrations of phosphorus are also relevant. A microalgal-based process was tested at lab scale in order to assess the feasibility of treating MWPW without any dilution or pre-treatment. Different microalgal strains and populations were tested. Based on the obtained results, Scenedesmus acuminatus (SA) and a mixed population (PM) chiefly made of Chlorella, Scenedesmus, and Chlamydomonas spp. were grown in duplicate for 70 days in Plexiglas column photobioreactors (PBRs), fed continuously (2.5 L culture volume, 7 days hydraulic retention time). Nutrient removal, microalgae growth, photosynthetic efficiency, and the composition of microalgal populations in the columns were monitored. At steady state, the microalgal growth was similar for SA and PM. The average removal efficiencies for the main pollutants were: 93% (SA), 94% (PM) for COD; 88% (SA) and 90% (PM) for total N; and 69% (SA) and 73% (PM) for total P. The residual pollution levels in the effluent from the PBRs were low enough to allow their discharge into surface waters; such good results were achieved thanks to the synergy between the microalgae and bacteria in the CO2 and oxygen production/consumption and in the nitrogen mineralization.


The increase in domestic violence—particularly against women—is one of the most alarming indirect effects of the COVID-19 pandemic affecting countries worldwide. Following a mixed-methods approach, this paper examines religious leaders' perspectives on and their engagement with this topic. It scrutinises the findings of the online survey Religious Leaders' Perspectives on Corona, conducted from 2020 to 2021 by the Research Programme on Religious Communities and Sustainable Development at Humboldt-Universität zu Berlin. Most answers came from the African continent and showed that more female than male leaders perceived an increase in domestic violence during the pandemic or see the need to respond to this topic. However, both male and female participants warned that domestic violence is underreported, inter alia, because of religio-cultural norms. To illustrate how the relationship between women and men in marriage is understood and (re)interpreted and how domestic violence is addressed in individual communities, this paper additionally draws on semi-structured interviews with church leaders conducted in Burkina Faso, Ghana, Kenya, Nigeria, South Africa, Tanzania, and Uganda from 2017 to 2019 and in 2022. In addition to forms of support and advocacy against domestic violence, the examples also show that church leaders might call for women's empowerment while upholding the idea of male headship.


Interspecific competition plays a key role in shaping carnivore communities. Top‐down effects can impact the coexistence of superordinate and subordinate competitors and prey across a shared landscape. Limited resources, their abundance and diminishing habitats can all exacerbate interspecific competition. Sometimes, behavioural mechanisms or adaptations are critical for subordinate carnivores to coexist with larger species. Here, we investigated the distribution pattern of the striped hyaena (Hyaena hyaena) population with respect to habitat features, sympatric carnivores and their prey species across a large landscape.Western and Eastern Ghats, India.Striped hyaena.We collected presence–absence data for hyaenas, tigers, leopards, dholes and their prey using camera‐trapping and indirect sign surveys. Using a random forest algorithm, we modelled the local distribution of hyaenas as a function of important ecological variables, including climate, domestic prey abundance and the predicted probabilities of occurrence of other large carnivores and their prey.We found that striped hyaenas were confined to relatively small, discrete areas compared to the three other predators, likely a mechanism for achieving coexistence in the landscape. Our empirical results suggested that hyaenas tend to avoid high occurrence probability areas of their co‐predators at a landscape level but foothold opportunities such as, arid climatic conditions, and prey abundance primarily determined spatial incumbency. Coexistence in an area with low to medium relative abundance of co‐predators offsets the interplay between carcass acquisition and risk associated. The coexistence of species was favoured by altitudinal heterogeneity probably providing denning refugia and also by their preference towards suboptimal thorn forests that sustain a low density of co‐predators.Our study showed a desisting impact of large predators on the distribution of the striped hyaena population. Furthermore, we suggest preventing habitat alteration in suboptimal habitats of large carnivores to facilitate coexistence in a shared landscape.


Similar experimental conditions for the aerobic oxidation of aldehydes but different isolated yields and reaction times have been recently published in Green Chemistry. These reactions have been reinvestigated.


Serum levels of thyroxine and triidothyronine were estimated in 24 workers engaged in contraceptive pills industry and 20 control subjects. Serum thyroxine in exposed subjects was significantly lower compared to its level in controls. On the contrary, triiodothyronine was significantly higher in exposed workers. So, it is concluded that exposure to the dust of contraceptive drugs, namely estrogen and progesterone, produced disturbances in thyroid gland function and thyroid hormone metabolism.


Thurber House guest James B. Stewart, author of Tangled Webs: How False Statements are Undermining America: From Martha Stewart to Bernie Madoff.


A 14-year-old boy with recent antibiotic treatment for tonsillitis, presented to the emergency department with 1-week history of worsening rash and haemorrhagic bullae involving the bilateral legs, trunk and hands (figures 1 and 2). Laboratory results were significant for proteinuria (2+protein) and haematuria (1+, 5–10 red blood cells/high power field); 24 hours urinary protein and renal function were within normal limits. The patient had an inconclusive skin biopsy. Figure 1 Left and right images show palpable purpura with some overlying bullae and vesiculation coalescing into plaques on both lower extremities. Figure 2 Left image shows rash on abdominal wall and right image shows coalesced haemorrhagic bullae on hands. Questions What is the most probable diagnosis? Bullous Ig A vasculitis Meningococcemia Bullous impetigo Eosinophilic granulomatosis with polyangiitis Cryoglobulinemia What is the best test which will establish the diagnosis in this patient? Renal ultrasound Renal biopsy Abdominal ultrasound Creatinine clearance What is first line of treatment in this patient? Antibiotics Steroids Surgical debridement Multispecialty consultation Immunosuppressants such as azothioprine What other systems can this condition affect besides the skin? Lungs Kidneys Spleen Nervous system A, B and D Answers can be found on page 02.


A pentadecanucleotide sequence, TTTCAACAAATAAGT, contiguous with the 5′‐end of Saccharomyces cerevisiae tRNA‐Leu3 coding sequence acts as a positive modulator of transcription in a homologous in vitro system. To determine whether modulation also takes place in vivo, the amber suppressor forms of tRNA‐Leu3 genes with different 5′‐flanking sequences were generated by site‐specific mutagenesis and cloned into YCp19, a yeast vector maintained at 1‐2 copies per cell. These plasmids were transformed into S. cerevisiae strains marked with amber mutations lys2‐801, met8‐1, and tyr7‐1. The ability of the tRNA‐Leu3 amber suppressor genes (tDNA‐Leu3A) to suppress functionally lys2‐801 and tyr7‐1 mutations in the yeast host strain correlated well with template activities measured in vitro. We conclude that the plasmid‐borne tRNA gene acts as an effective suppressor from the plasmid and the conserved pentadecanucleotide sequence modulated the expression of yeast tRNA‐Leu3 in vivo as well as in vitro. This regulatory sequence if found associated with genes coding for a number of tRNAs which are abundant in yeast. We postulate that this sequence represents a mechanism by which production of specific tRNAs can be enhanced to match demand created by codon use preferences.


"Functional Foods" are defined as a group of foods that are produced to draw out the satisfactory functions useful for human health. Each constituent of so-called "Functional Foods" is considered to take a role in maintenance of well-balanced physiological condition including the regulation of self-defence mechanisms, biological rythm in human life and prevention or recovery of various diseases. Standardization of "Functional Foods" aroused the public interest and various opinions were expressed by correlated people. A committee for the examination of "Functional Foods", consisted by 22 expert members, fully discussed these opinions from all viewpoints including international movements. The final report by the committee was submitted to the Ministry of Health and Welfare in 1990. In this report, "Foods for Specified Health Use" is newly used instead of "Functional Foods". This term is defined as the foods that are expected to have some good effects on the preservation of health from the consideration of the relationship between human health and foods or food constituents. "Foods for Specified Health Use" is permitted to be expressed on the foods for special people who take these foods for some limitted purpose related to the preservation of health. This manuscript will represent the process of the change of the terminology for this group of foods and an outline of the new institution for "Foods for Specified Health Use" will be shown.


Several kind of anisotropic conductive films (ACF) with different material properties and the reliability test results have been developed in this study. The ACFs with various thermal properties, higher glass transfer temperature (Tg) and lower Tg, are developed by selecting different kind of curing agents or toughners. Reliability test also has been investigated in this study. The ACF shows perfect reliability properties after high temperature storage at 150degC for 500hrs, high temperature (85degC)/high humidity(85R.H.%) for 168 hrs and thermal cycling test (-40degC~125degC) after 500 cycles. Because of good adhesive strength of COG package, it shows good reliability properties even material with lower Tg and higher coefficient of thermal expansion (CTE).Material ACF3 shows strong shear strength (>15kgf) after ACF bonding and also after thermal aging test for 1000hrs at 85 deg;C The shear strength after ACF bonding of ACF1 and ACF2 are lower than ACF3 but they can keep the strength not to decrease after the thermal aging test. The shear strength of ACF3 is decreased much than ACF1 after 1000hrs thermal aging at 150deg;C ACF3 shows high Tg and good adhesion after bonding but ACF1 shows better adhesive properties after thermal aging test. ACF3 failed after high temperature and high humidity test (85deg;C/ 85R.H. %) because of its humidity sensitive property. ACF1 shows perfect adhesive strength after high temperature and high humidity test (85deg;C/ 85R.H.%) for 1000hrs. ACF3 has good thermal property (high Tdeg) but poor reliability properties since it's humidity sensitive. ACF1 shows perfect reliability test because of strong adhesive strength even with lower Tdeg. The ACFs with higher and lower Tdeg are both developed in this study. Good reliability properties of ACF, diamine and phenolic material, can be achieved by the strong adhesive strength in COG package even it's Tdeg is lower than 100degC


The merger of SCADA (supervisory control and data acquisition) and IoTs (internet of things) technologies allows end-users to monitor and control industrial components remotely. However, this transformation opens up a new set of attack vectors and unpredicted vulnerabilities in SCADA/IoT field devices. Proper identification, assessment, and verification of each SCADA/IoT component through advanced scanning and penetration testing tools in the early stage is a crucial step in risk assessment. The Omega2, a small Linux server from Onion™, is used to develop various SCADA/IoT systems and is a key component of nano power grid systems. In this paper, we report product level vulnerabilities of Onion Omega2 that we have uncovered using advanced vulnerability scanning tools. Through this research, we would like to assist vendors, asset owners, network administrators, and security professionals by creating an awareness of the vulnerabilities of Onion Omega2 and by suggesting effective mitigations and security best practices.


What is the relationship between what we, in our most reflective and circumspect moments, desire or approve of and what is our good? In this essay I will explore the views of St. Thomas Aquinas on this issue. I will develop my interpretation of Aquinas dialectically by considering and criticizing aspects of the influential interpretations of Germain Grisez2 and John Finnis,3 on one hand, and Ralph Mclnerny,4 on the other.5 These interpretations, I will


THE significance of state and local history in the public schools of Pennsylvania may be considered from s veral different points of view, depending upon the speaker and the character of his audience. Of these points of view probably the first and most natural is that of the historic past of the state of Pennsylvania and of its various communities. A brief statement, however, offers no satisfactory opportunity to develop this point of view. A survey would contain little if anything not familiar to everyone. Items such as the Dutch and Swedes on the Delaware, the Eng lish conquest and occupation from 1664 to 1681, William Penn and the settlement of Pennsylvania, the social and economic features of colonial Pennsylvania, the Pennsylvania fur trade and the westward movement, Pennsylvania in the French and Indian War, Pennsylvania and the American Revolution, agriculture, transportation and industry in the state of Pennsylvania, the establishment of public schools in Pennsylvania, Pennsylvania in the Civil War, sections and sectionalism in Pennsylvania, and the place of Pennsylvania in the nation today, political, economic and social, each calls for monographs or books rather than a survey. Another and a very different consideration of the topic is that from the point of view of the actual utilization of state and local history in the curriculum and instruction of the public schools of Pennsylvania. An educationist, particularly the alleged scientific educationist with his emphasis upon fact-finding, would very probably handle the topic from this viewpoint. Questionnaires by the thousands might be sent out and an elaborate presentation of statistics be made. Possibly an audience composed mainly of teachers would greatly prefer such treatment of the subject. But this work can be done more easily by assistants in the Bureau 158


Much work has already been done on this subject, though little of a quantitative character. Many observers have described the curious our sensations which rapid alternations of light and darkness can cite under certain conditions, admirably exemplified in the "spectrum tops." Foremost amongst those whose experiments and writings have led to the present very general interest in the subjects of flicker, and of the sensation of light and colour, may be mentioned Helmholtz, vanus Thompson, Shelford Bidwell, Henry, Charpentier, and tod; whilst the first to try experiments on the relative sensitivess of the eye to flicker in light of different colours, seems to have been J. Plateau, who, however, employed pigments, and not the colours of the spectrum.


Background: Diabetic complications are strongly attributed to poor foot care knowledge and practice. Knowledge about diabetes enables patients to play an active role in effective diabetes self-management. Proper daily foot care is an effective part of diabetic foot ulcer (DFU) prevention and enables diabetic patients to early detect foot abnormalities and injuries, thus reduce or even prevent the risk of foot ulceration. Objectives: to measure foot care knowledge and to identify possible associated factors among Egyptian diabetic patients attending three Family Medicine centers in Cairo Methods: A cross-sectional study was carried out in three Family Medicine centers on140 diabetic who met the inclusion criteria. Data on foot care knowledge was collected using a structured interview questionnaire. Results: More than half (62.1%) of the participants had poor foot care knowledge, 24.3% had satisfactory level and only13.6% have good knowledge. The mean of knowledge score was as follow in the three centers; El Sadis (7.18±2.697) El Darrasa (6.92±3.168) and in Saraya was (5.96±3.037) and no statistical difference in foot care knowledge score or grade was found between the three centers. A strong and significant relation was found between income and knowledge grade. Also Longer disease duration and history of foot ulcer were associated with good foot care knowledge. Conclusion: Poor foot care knowledge was evident among the study participants in the three Family Medicine Centers and hence interactive health educational programs targeting type 2 diabetic patients are strongly recommended.


The experimental system of Supercontinuum generation by fiber splice has been demonstrated.In this system,photonic crystal fiber and normal single-mode fiber are used to reduce loss in order to solve the problem of splice among photonic crystal fiber.With a nanosecond pulsed laser as the pump source,the photonic crystal fiber and single-mode optical fiber of HI-1060 were spliced,on the basis of which the broadening process was analyzed.The results show that the 0.48 W supercontinuum with the spectral range over 1100 nm was demonstrated in splicing of a 20-m-long photonic crystal fiber and 1-m-long single-mode optical fiber at the average pump power of 2.2 W and the repetition rate of 150 kHz.


It has been concluded that both 2-methyl-2-propanethiol and 2-methyl-2-butanethiol are plastic crystals and that, in their highest temperature crystalline phases, molecules perform a rotational motion on the lattice sites. The intermolecular S–H…S hydrogen-bond, which might possibly exist in these phases, seems to be too weak to hinder the molecular rotation. Cyclohexanethiol does not seem to be a plastic crystal, probably because of its low molecular symmetry in the solid phase and its intermolecular hydrogen bond.


With the advent of knowledge economy,personal knowledge management from the enterprise into the field of education and produce great changes in education field.Teachers for special education and trained,pass to students in school of human scientific and cultural knowledge and skills,continuously improve the personal knowledge management,in today's society has become the urgent need of development of teachers. Based on this,this article discusses the concept and significance of the teachers' professional development and personal knowledge management and put forward the personal knowledge management of the strategy of teachers' professional development.


The physical processes driving chemical evolution in the Milky Way can be probed using the distribution of abundances in low-mass FGK type stars in space phase at different times. During their final stages of evolution, stars experience nucleosynthesis several times, each at different timescales and producing different chemical elements. Finding abundance ratios that have simple variations across cosmic times therefore remains a challenge. Using the sample of 80 solar twins for which ages and abundances of 30 elements have been measured with high precision, we searched for all possible abundance ratio combinations that show linear trends with age. We found 55 such ratios, all combining an n-capture element and another element produced by different nucleosynthesis channels. We recovered the ratios of [Y/Mg], [Ba/Mg], and [Al/Y] that have been reported previously in the literature, and found that [C/Ba] depends most strongly on age, with a slope of 0.049 ± 0.003 dex Gyr−1. This imposes constraints on the magnitude of the time dependency of abundance ratios in solar twins. Our results suggest that s-process elements, in lieu of Fe, should be used as a reference for constraining chemical evolution models of the solar neighbourhood. Our study illustrates that a wide variety of chemical elements measured in high-resolution spectra is key to meeting the current challenges in understanding the formation and evolution of our Galaxy.


An electronically tunable polarization rotator based on tensor metasurfaces operating at 10 GHz is reported. The metasurface design allows the polarization tilt angle of a linearly polarized wave to be arbitrarily controlled through a simple biasing mechanism. In addition to allowing global polarization control, the design also allows global phase control.


The competitive force of bank at the core is the competitive power that is at core position and affects overall situation.It studies how to realize the maximum of bank profits in view of diversification of bank's business and rapid expansion of the capital scale. High-speed development of commercial bank's intermediary business have made the competitive force at the core of the western commercial bank obviously enhance. We must develop quickly intermediary business and strengthen the competitive force at the core to face up with competitive international market environment.


The author argues that there exists similarity, namely, spirit comfort, between Ah Q spirit and Zhuangzi's thoughts. Also, spirit comfort is positive in that spirit comfort and go aheadism are two sides of a coin in traditional Chinese thinking. This comparative study shows Ah Q spirit is the popular version of Zhuangzi's thoughts while the latter is the former's theoretic version.


This tiny note concerns the spectral analysis of models of random Markov kernels, centered around joint works in collaboration with Charles Bordenave and Pietro Caputo, with a "large random matrices" point of view. Some open problems are given. A (rather old now) survey about the spectral analysis of large random Markov kernels can be found in [9]. An up to date review can be found in the Habilitation thesis of Charles Bordenave under preparation (gives a complete bibliography). These models can be seen as random walks or Markov chains in random environment. From the random matrix theory point of view, these random matrices have dependent entries, and what is know concerns mostly first order asymptotics for empirical spectral distributions, spectral edge, and principal eigenvector. In particular, the study of the asymptotic fluctuations is completely open.


Abstract Introduction: Anal stenosis is a rarely seen type of anorectal malformation for which a variety of treatments have been described, including cutback anoplasty, posterior sagittal anorectoplasty (PSARP), and a formal anoplasty, all done with or without colostomy, with inpatient stays and a significant anorectal dissection. The aim of this video is to demonstrate the use of an innovative and less invasive technique to treat congenital anal stenosis in a 2-year-old boy. Materials and Methods: The patient presented with recurrent episodes of constipation and fecal impaction from birth. He was found on examination to have anal stenosis, with a 2 mm depth of narrowed area and healthy rectum more proximal to this. Under general anesthesia, he was positioned prone, traction silk stitches were placed on the anal skin circumference, and radial incisions were made using cautery on the skin and adjoining mucosa, sequentially, at the 12, 3, 6, and 9 o'clock positions to release the stenosed ring. The resultin...


In any case, Dr Verhagen points out, the official opinion of the American Academy of Pediatrics is that it is morally permissible to withdraw or withhold hydration and nutrition from newborns in some cases.


Employing a Bayesian approach, we investigate the impact of international business cycles on the U.K. economy in the context of a smooth transition VAR. We find that the British business cycle is asymmetrically influenced by growth in the U.S., France and Germany. Overall, positive and negative shocks generating in the U.S. or France affect the U.K. in the same directions as the shock. However, a shock emanating from Germany, whether positive or negative, always exerts negative cumulative effects on the U.K. Further, a positive shock arising from Germany adversely affects the U.K. output growth more than a negative shock of the same size.


Relevance of the research topic. The Constitution of the Russian Federation establishes the equality of all subjects before the law and the court. However, the law establishes categories of citizens with immunity (immunity from criminal prosecution). Immunity was not a personal privilege and could be waived by the decision of a competent public authority. The moment of deprivation of immunity falls at the stage of initiation of criminal proceedings. The problem arises of the ratio of procedures for deprivation of immunity and pre-investigation verification, since the relevant actions are not simply regulated by different laws, but have a different legal nature.
Setting of a problem. In criminal proceedings the procedure for depriving a person of immunity must be followed in order to bring to justice a person who has immunity from criminal prosecution. In the science of criminal procedure no distinction was made between pre-investigation verification and deprivation of integrity in full. It is not clear whether the state authorities that decided on the deprivation of immunity were involved in criminal proceedings, what issues should be clarified within the framework of the deprivation of immunity and the extent of the rights of the person in respect of whom the question was raised.
Research objectives and methods. The purpose of the study is to determine the ratio of procedures for deprivation of immunity from criminal prosecution and pre-investigation verification. The objectives of the study are to investigate the legal nature of the deprivation of immunity from criminal prosecution; distinguish between this procedure and pre-investigation verification; review the criminal procedure situation of the authorities involved in the deprivation of immunity; summarize the rights of the person in respect of whom the issue of deprivation of liberty is being addressed. The methodological basis of the study was the dialectical-materialistic method, as well as the general scientific methods of scientific knowledge: analysis and synthesis, induction and deduction, formal-logical, systemic.
Results and key conclisions. Deprivation of immunity is a complex intersectoral procedure, which has a constitutional, criminal procedure and administrative-legal nature at the same time. The question of deprivation of immunity is resolved by the competent public authorities (often the highest public authorities), which are not ordinary participants in criminal proceedings, but resolve certain criminal procedural issues.
The person in respect of whom the question of deprivation of immunity is decided should be granted rights similar to those granted to protect against criminal prosecution: to bring his position to the competent authority; qualified legal aid; to appeal against the decision. In the course of deprivation of immunity, the principle of presumption of innocence, which has a specific refraction, applies. The terms of the deprivation of immunity procedure exist separately from the terms of the pre-investigation check. In the future the ratio of initiation of criminal proceedings and deprivation of integrity should be changed. A decision must first be taken to initiate a case and then a procedure must be followed to remove immunity from criminal prosecution.


The different factors in road traffic safety - the road user, the road, weather, vehicles and government policy are discussed. If greater safety is required, then a coherent policy is needed for all these factors. The most dangerous situations have to be dealt with first. Drivers learn from experience, so measures should be taken as uniformly as possible to improve dangerous spots and circumstances. The authorities have to realize that a traffic light placed at a crossing has consequences for other intersections. For the covering abstract see TRIS abstract No. 368574. (TRRL)


Ultrasound Imaging plays vital role in diagnoses a disease. US image suffers from speckle noise. Despeckling is an important task for accurate diagnosis. In this paper experiment has been performed to measure the effectiveness of various filters available for despeckling. Results are compared qualitatively and quantitatively the Peak Signal to Noise Ratio and SSIM parameters are used to quantify the results. On the basis of these parameters the performance of various filters are shown.


You could be reading the full-text of this article now if you... Become a subscriber Purchase this article If you have access to this article through your institution, you can view this article in Journal of Hypertension: June 2015 doi: 10.1097/01.hjh.0000469728.67622.d6 Abstracts: PDF Only The Evaluation of New Index for Blood Pressure Variability Using Posture Change Among Older Fallers. Goh, Choon-Hian; Ng, Siew-Cheok; Kamaruzzaman, Shahrul B.; Chin, Ai-Vyrn; Poi, Philip J.H.; Chee, Kok Han; Abidin, Imran Z.; Tan, Maw Pin While postural hypotension has long been considered a risk factor for falls, there is currently no documented evidence on the relationship between blood pressure variability (BPV) and falls. A case-controlled study involving 25 fallers and 25 non-fallers was conducted to evaluate the utility of BPV calculated using previously published and newly introduced index using the variables falls and age as comparators. Systolic (SBPV) and diastolic blood pressure variability (DBPV) were assessed using three indices: standard deviation (SD), average real variability (ARV), and standard deviation of real variability (SDRV). Continuous beat-to-beat blood pressure was recorded during ten minutes' supine rest and three minutes' standing. Standing SBPV was significantly higher than lying SBPV using three indices in both groups. The standing to lying BPV ratio (SLR) was then computed for each subject (SD, ARV, and SDRV). Standing to lying ratio for SBPV was significantly higher among fallers compared to non-fallers using SDRV (p = 0.025). This study suggests that SLR SBPV using SDRV is a potential predictor for falls among older patients, and deserves further evaluation in larger prospective studies. Copyright (C) 2015 Wolters Kluwer Health, Inc. All rights reserved.


Reverse osmosis experiments were performed to concentrate the green tea juice, and the experimental data was analyzed by using a set of transport equations together with osmotic pressure and density data of the green tea juice. the transport parameters obtained numerically by the above analytical procedure were then used to calculate several dimensionless quantities that can characterize a reverse osmosis module. an example of module design calculation was attempted using the dimensionless parameters so obtained. It has been found that an increase in operating pressure reduces the module length significantly when the feed tea juice concentration is high. an increase of the mass transfer coefficient on the high pressure side of the membrane has the same effect.


Public trust in government is crucial for good governance, encompassing economic and social development of the region in a representative democratic setup. This study uses India Human Development Survey (2004–2005 and 2011–2012) data to examine the changing pattern of household confidence in state governments in India. Using a logit model analysis, we examine how the level of household confidence in the state government changes with households' socioeconomic status, personal experiences, and benefits received from government programs and direct social benefit schemes. We find that households with a low socioeconomic status (such as Scheduled Castes/Scheduled Tribes, and low-income and less educated households) are more likely to trust the state government. In addition, households that have had a positive experience or have received benefits from a government program and/or social scheme are more likely to exhibit high levels of trust in the state government. We also find that residents of less developed states are more likely to have high levels of trust in their state government than residents of highly developed states.


Inhibitory effects of reserpine on ecdysis and chromatic adaptation in Oedipoda appear to be linked with changes observed in both neural and neuro-endocrine regulating systems.


Purpose
This paper aims to estimate willingness to accept (WTA) hypothetical nuclear energy projects and the impact of net perceived benefits across three countries: Italy, a country without nuclear plants in operation; the UK, a country with nuclear plants in operation and the United Arab Emirates (UAE), which has more recently opted for the inclusion of nuclear energy in its energy mix. These valuations can support cost-benefit analyses by allowing policymakers to account for additional benefits and costs which would be otherwise neglected.

Design/methodology/approach
Data collection was conducted through online nationwide surveys, for a total of over 4,000 individuals sampled from Italy, the UK and the UAE. The surveys included choice experiments designed to elicit preferences towards nuclear energy in the form of WTA, indicating estimated compensations for welfare worsening changes and questions to measure perceived risks and benefits.

Findings
The average WTA/Km is the lowest for the case of the UAE. What is more, perceived net positive benefits tend to decrease the WTA required by the UAE respondents? Moreover, across the cases, albeit to a lesser extent with regard to Italy's case, there is evidence that a more positive benefit perception seems to increase the valuation of environmental and public benefits offered as part of the experiment.

Originality/value
The contribution of this study is primarily twofold: first, it provides a comparison of WTA values in a context where the availability of choice experiment data is scant; second, it assesses whether and to what extent perceived net positive benefits of nuclear energy impact WTA of nuclear energy projects.


Customer Relationship Management is an ideology to manage company's interaction with existing and future customers. Today it is an inevitable for any business because of heavy competition and globalization. Every organization thrives to withstand in the competition for that they have to retain their customers as well as develop their products. Especially for the hotel industry it has to come up with distinctive ideas to show their uniqueness in the industry as well as with their current and potential customers. However there will be a limited study in the survey area about CRM. This observation strive to manifest how the impact of Customer Relationship Strategy with organizational performance


Describes the Cretaceous-Eocene sequence of the southern Istrian peninsula, Yugoslavia, and compares it with corresponding sequences of the Dinaric Alps and Greece. The data indicate the presence of a topographic high in the depositional basin, extending from Greece northward to Istria, for which the name Dalmatian zone is proposed. In Greece, where it separates the Ionian trough on the west from the Pindus trough on the east, it is known as the Gavrovo zone.


The Pulang complex in Yunnan Province is divided into three stages of intrusions based on their contacting relationship and petrological characteristics.The lithologies of the intrusions include quartz dioritic porphyry formed in the first stage,quartz monzonitic porphyry in the second stage,and granodioritic porphyry in the third stage.The crystallization ages of the intrusions were determined by using the single-grain zircon U-Pb method.The single-grain zircon U-Pb isotopic ages are defined as 221.0±1.0Ma, 211.8±0.5Ma and 206.3 + 0.7Ma for the first,second and third stages of intrusions,respectively.These data combined with the results of petrochemical and Sr isotopic analyses support the formation of the Pulang complex in the lndo-Chinese epoch by multi-stages of gushing emplacement of the magmas derived from mixing source of mantle with crust.


The Prostate Imaging Reporting and Data System (PI‐RADS) was introduced in 2012 and updated to version 2.1 (v2.1) in early 2019 to improve diagnostic performance and interreader reliability.


Simple and label-free electrochemical sensors for the detection of DNA hybridization were developed based on charge perturbation of poly(thionine)-modified glassy carbon and gold electrodes (PTH/GCE and PTH/Au). Probe DNA (pDNA) was immobilized on PTH films via covalent bonds between the amine (-NH2) group of the PTH and the phosphate (PO43−) group at the 5′ end of the pDNA. The immobilized single-strand pDNA decreased the oxidation current of [Fe(CN)6]4− as a result of electrostatic repulsion by the negatively charged PO4 backbone of the pDNA. The current was further decreased subsequent to duplex formation by the hybridization of target complementary DNA (cDNA) due to increased electrostatic repulsion. Both sensors demonstrated excellent selectivity, stability, and the sensitivity of 1.27 and 58.6 μA · cm−2 · pM−1 with detection limits of 0.47 and 0.20 pM, respectively, for cDNA hybridization. © 2015 The Electrochemical Society. [DOI: 10.1149/2.0291507jes] All rights reserved.


Despite recent advances in optical ultrafast measurement, simultaneous measurement of amplitude and phase of fast optical fields having complex evolutions over large time window remains a largely open problem. Here, we demonstrate two novel and complementary techniques that allow in particular the single-shot recordings of amplitude and phase of irregular waves with a high temporal resolution over a long time window.


A novel two-channel algorithm is proposed in this paper for discriminative training of Hidden Markov Models (HMMs). It adjusts the symbol emission coefficients of an existing HMM to maximize the separable distance between a pair of confusable training samples. The method is applied to identify the visemes of visual speech. The results indicate that the two-channel training method provides better accuracy on separating similar visemes than the conventional Baum-Welch estimation.


Based on the thermodynamic and kinetic analyses in previous papers, three feed-ways of mixed hydrogen, CH_4/(CO_2-H_2), (CH_4-H_2)/CO_2 and (CH_4-CO_2)/H_2, have been contrived to convert directly CH_4 and CO_2 into oxygenic compounds in a two-step sequence. These feed-ways have been principally probed on Cu-Co, Ru-Co and Pd catalysts, and the influence of hydrogen content in both H_2-CO_2 and H_2-CH_4 has been also studied. Compared with CH_4/CO_2, all these feed-ways containing hydrogen can improve the yield of acetic acid. However, some measures should be adopted to control the competition of CO_2 hydrogenation. In (CH_4-H_2)/CO_2 feed-way, when the hydrogen content in H_2-CH_4 flow reaches 13.8%, the yield of acetic acid reaches the highest; in CH_4/(CO_2-H_2) feed-way, when the hydrogen content in CO_2-H_2 flow reaches 50%, the yield of acetic acid is the highest. The fresh and the used Cu-Co and Ru-Co catalysts have been characterized, and the surface element composition of the catalysts has been analyzed. For Cu-Co catalyst, after the reaction the Co is enriched on the catalyst surface in CH_4/CO_2 feed-way, but the Cu is enriched on that in the feed-ways of mixed hydrogen, which is consistent with their catalytic performance. For RuCo/13X zeolite catalyst, there is nooverlap between Ru and Co. The Co attaches equably to the support surface, but the Ru acts more with the component of support. In the reaction atmosphere, that Ru and Co are enriched on the catalyst surface is also consistent with their catalytic performance.


This research was aimed to prove whether the leadership style of high initiative structure and high consideration (group C) more increasing communication dimension (information saturity, bondary spaning and information accuracy) in auditing team comparing to the leadership style of other groups. The sample of this research was auditor who work at auditing division at big, medium and small public accounting office (KAP) in Java Island. The data analysis method used was ANOVA and Tukey test. The result of this research indicated that the leadership style of group C got information saturity and increased information accuracy comparing to the leadership style of other groups. The result of this research also found that there was no differences of leadership of group A,B,C, and D to increase the akcivities of bondary spaning.


Objective: To analyze the effect of ruthenium red and tetracain for ryanodine induced [Ca~(2+)]i releasing in pulmonary artery smooth muscle cell(PASMC) in rats with pulmonary artery hypertension(PAH). Metnods: The experimental rats were divided into 2 groups.PAH group,n=15,the rats received intraperitoneal injection of monocrotaline 60 mg/kg,and Control group,n=8,the rats received the same volume of normal saline.PASMC was primarily cultured with fluorescence Fura-2/AM.The effect of ryanodine,ruthenium red and tetracaine for [Ca~(2+)][Ca~(2+)]i releasing in PASMC were measured by fluorescence microscopy. Results: With 10 nmol/L ryanodine treatment,the [Ca~(2+)]i releasing in Control group increased by the average of(93.31±12.41) nmol/L,in PAH group increased by the average of(141.71±13.59) nmol/L,P0.01 respectively.With(0.5~10) μmol/L ruthenium red treatment,and with(2~40)μmol/L tetracaine treatment,in PAH group,ryanodine induced i releasing decreased at the maximum as(115.32±7.47)nmol/L and(107.97±7.11) nmol/L. Conclusion: The PASMC in PAH rat has the higher sensitivity to ryanodine receptor agonist.Ruthenium red and tetracaine can inhibite the ryanodine induced PASMC [Ca~(2+)]i releasing in PAH rats.


This article aims to make a close inquiry into the problematic status of emotion of our age in SNS. Emotion through media, that is, mediated emotion is not just a expression of emotion. Every media is not transparent as language also isn`t. Media is not just a means for communication, but structural mechanism which constructs communication itself. In our age human being comes to possess a most fast and extensive means for expressing and sharing emotions and by that makes it inevitable to ask what kind of transformations in structure and formula of our emotion will bring about this new media innovation. Expression as psychological unit is social and cultural construct as well as individual. In this respect, core question is about the problematic relation between contemporary media-scape in the name of SNS and so-called emotion-inflation of our age. Digital media scene including SNS is not just a medium for communication, but the actual spot where takes place interesting identification play which is strongly colligated to consumerism, for instance by stylization of tastes. As a microcosmos of self-identity, it can function as very effective symbolic integrator of subject. At the same time, SNS scene serves as the most vivid and live stage of cultural model of intimacy. The dominant formula managing this stage is what is called cold intimacy as characteristics of modern type of human relationship, and this shows well the real circumstances of emotion-capitalism where every emotional relationship can be calculated and rationalized(and in the long run can be purchased and sold). On the other hand, the huge possibilities of active participation of SNS users (interactivity) also have a potential threat of being transformed into pseudo-activity which is termed interpassivity by S. Zizek. This ambivalent aspects of SNS demand more close and comprehensive reading of SNS media-space, that is media-phenomenology for SNS.


WT5"BZ]The paper discusses the significance of which the journals of colleges and universities carry out Chinese Academic Journal(Light Disc Edition)Retrieval and Evaluating Data Standard.It also analyzes the concrete problems which exist in the process of putting it into practice.It also puts forward the concrete measures to carry out it. [WT5"HZ]


The integrated geotechnical approach has provided efficient, cost effective, accurate data for design and construction of the San Francisco-Oakland Bay Bridge (SFOBB) East Span Replacement. The new structure will span over 4 km from the Yerba Buena Island to the Oakland shore, and will carry over 280,000 motor vehicles per day. Geotechnical studies included land and marine geophysical surveys, conventional land drilling, and sophisticated marine drilling and in situ testing. An onboard laboratory allowed the collected subsurface data to be immediately incorporated into the project geotechnical Geographic Information System. This approach also allowed site characterization and earthquake site response analyses to proceed concurrently with the site investigation, thus shortening the overall timeframe for design. This paper describes the marine exploration and the site characterization activities for the project.


I spent my final day in Camden at the city's other high school, Woodrow Wilson, which also has its difficulties in retaining students. The dropout rate at Woodrow Wilson High is 58 percent, a number that does not include the 10 to 20 percent of would-be Wilson students who drop out in junior high and therefore do not show up in official figures. Of the nearly 1,400 children who attend this school, more than 800 drop out in the course of four years. About 200 finally graduate each year. Only 60 of these kids, however, take the SATs—prerequisite for entrance to most four-year colleges.


Nitrogen is one of the three essential nutrients in the terrestrial ecosystem and is regarded as a main limited factor in the forest ecosystem.With the rapid development of agriculture and industry in recent years,more and more nitrogenous compounds have been emitted into the atmosphere.As a result,the terrestrial ecosystem has been damaged seriously,espically forest ecosystem.It is reported that if nitrogen has got to saturation or even exceeded the critical load value of ecosystem,it will be negative to the ecosystem.This paper treats of some concepts of atmospheric nitrogen deposition at first,such as nitrogen saturation the indicator of nitrogen deposition value,and then summarizes the studies of nitrogen deposition at home and aboard.At last,much attention is paid to the effect of atmospheric nitrogen on the forest ecosystem.It is found that nitrogen deposition can break the nutrient balance,strenghten the sensitivities to stress and accelerate the soil acidification process,and can also lead to the increase of nitrogen leaching from soil and the decrease of biodiversity.In order to assessing the effect of nitrogen deposition correctly,some methods are introduced which have been used by John D.Aber.


In 2008,it was study that the need water dynamic determination of Ditch Sowing in Double Ridge Mulched with Plastic Films in Huining County.The results showed that the water demand in corn growing period about 264 mm.The reason was known that not lack the total of precipitation,but precipitation and growth need water does not correspond,especially the corn in the large bell period and the water demand in the peak water which needed precipitation supplement,as no effective rainfall.So,rainwater harvesting should be adopted,such as supplementary irrigation and drought measures in the initiative.


We tested the hypothesis that an imbalance in angiogenic and anti‐angiogenic factors may play an important role in development and delayed healing of duodenal ulcers induced by duodenal ulcerogens cysteamine or propionitrile in rats. Scrapings of proximal duodenal mucosa were collected to study gene expression of collagen XVIII by microarray and Real‐time PCR, proteolytic activity of matrix metalloproteinases (MMP) by zymography and ELISA, and levels of angiostatin, endostatin and VEGF by Western blot and ELISA. Additional groups of rats were daily given endostatin for 3 and 7 days after cysteamine to test the effect of endostatin on ulcer healing. The results showed increased endostatin and angiostatin accompanied by elevated MMP2 activity in the early or late stages of ulceration, when VEGF levels were also markedly increased. Endostatin treatment significantly delayed duodenal ulcer healing. Conclusions: 1) Both anti‐angiogenic factors angiostatin/endostatin and angiogenic factor VEGF were upregulated in experimental duodenal ulceration. 2) Excess of anti‐angiogenic factors, e.g., endostatin and angiostatin may be one of important mechanisms in impaired ulcer healing. 3) Thus, an imbalance of angiogenesis regulators seems to be a new element in ulcer pathogenesis and healing.


The strength of free-standing chemically vapour-deposited diamond was determined using a bursting-disc test, a three-point bend test and a four-point bend test. The bursting-disc technique has advantages for determining the strength of ceramic materials since the maximum tensile stress is at the centre of the disc. The much smaller stresses near the sample edges are rarely responsible for failure and so edge effects are negligible. However, the bursting-disc test is often impractical for ascertaining the strength of chemically vapour-deposited diamond since the cost of samples is high. A three-point bend test is often employed instead, since it may be performed on smaller samples. However, the area stressed in the three-point bend test is smaller, and so there is less chance of stressing a large flaw, resulting in higher strength values. A further disadvantage is that specimen edges are stressed and, unless the specimen sides are polished, as well as its faces, misleading results may be obtained (although this is not the case for chemically vapour-deposited diamond). A four-point bend test is often used because it stresses a larger volume of material than the three-point bend test and so the results are more reliable. Furthermore, the diamond used in a four-point bend test can be of similar size to those used in a three-point bend test and so the expenditure is comparable. However, ensuring that the four-point bend test is applied correctly is technically more difficult. Strength data are reported for both the growth and the nucleation sides, for difference nucleation densities and for as-received and polished samples.


Table of ContentsI. Introduction 654A. The Gene Flow Problem 655B. Negligence Per Se as a Possible Solution 656II. Background of Genetically Engineered Crops 658III. Gene Flow and the Law 662A. Regulation of GE Crops 662B. StarLink Corn 667C. LibertyLink Rice 672D. Negligence Per Se 6741. Overview 6742. The Johnson Grass Statute 6763. Negligence Per Se in Cases of Gene Flow 6784. Shortcomings of Negligence Per Se 679IV. Possibilities for Future Regulation 681A. State Versus Federal Regulation of GE Crops 681B. Which Agency Should Establish the Standards of Care to Prevent Gene Flow? 683C. Regulations Reflecting Biological Realities 684V. Conclusion 691I. IntroductionIn his 1914 poem Mending Wall, Robert Frost questions the wisdom of the adage "good fences make good neighbors."1 The speaker in the poem tells the tale of a yearly ritual, performed by him and his neighbor, of restoring a wall between his apple orchard on one side, and the neighbor's pine grove on the other.2 Questioning the need for the wall, the speaker comments that his apples will not cross to eat the pinecones beneath his neighbor's trees.3But what if one farmer's crops could harm those of her neighbor? Would a fence be in order? If so, what would that fence look like? The reality in today's agricultural world is that there are, indeed, situations where crops can cause harm beyond the boundaries of the fields in which they are grown.4 This Note takes an example of such a harm - gene flow from genetically engineered (GE)5 crops to organic or conventionally bred crops - and proposes one type of fence that could be employed to help demarcate the limits of the responsibility that growers of GE crops have to their neighbors. This legal fence would assist such growers in keeping their transgenes safely corralled, and facilitate restitution if the transgenes escape and cause harm. Ideally, it would be the type of boundary that does, indeed, good neighbors make.A. The Gene Flow ProblemIncreased specialization in crops and reduced tolerances for genetic variation in general, and for transgenic material in particular, have led to a greater need to segregate GE crops from their conventionally bred and organic counterparts.6 The entire value of a farmer's crop may depend on the ability to ensure its genetic purity.7 The adventitious presence of undesirable genetic material, such as DNA derived from GE technology, can result in rejection or destruction of crops or products made from them.8At the same time that tolerances for GE traits have been tightening, GE crop production has been expanding.9 As GE crop production has increased, it has become clear that the agricultural industry in the United States is not prepared to keep GE crops separate from conventional or organic crops.10 The statutes and regulations dealing with GE crops have failed to prevent contamination of non-GE crops or to provide adequate remedies for those who have been harmed by such contamination. …


Purpose – The purpose of this paper is to present a framework approach to guide the identification of potential public private partnership (PPP) renegotiation outcomes is presented. The framework is applied to a road concession project under renegotiation in Greece. Design/methodology/approach – The framework combines the estimation of stakeholder payoffs with respect to the various strategic options available. Their potential acceptance is evaluated with respect to the power distribution within the stakeholder network. The contextual environment determines the respective power position of each stakeholder in the network. Findings – The proposed framework is applied to a road concession case in Greece, under renegotiation as a result of the economic crisis. The analysis highlights the importance of the contextual environment and the limitations of solutions that seem "satisfying" for all stakeholders involved. Social implications – The framework is designed to guide both public and private parties involve...


The cells made on CZ(B) (boron doped Czochralski) silicon substrates often exhibit degraded minority carrier lifetimes corresponding to poorer cell performance. The first part of this paper reports our cell results on a variety of CZ(B) substrates. Most of these CZ(B) cells showed a severely reduced cell performance after being stored for a period of time. The cells on higher resistivity CZ(B) substrates from Crysteco Inc., showed no degradation due to its low boron level of 10 Ωhyphen;cm resistivity.

The second part of this paper describes work avoiding this CZ(B) degradation problem by using different substrate growth methods or different dopant, such as MCZ(B) (boron doped magnetically-confined Czochralski grown), CZ(Ga) (gallium doped Czochralski), and FZ(B) (boron doped float zone) substrates. All these substrates were supplied by Shin-Etsu Handotai Co, Japan, (SEH). High efficiency PERL (passivated emitter, rear locally-diffused) cell and PERT (passivated emitter, rear totally-diffused) cell structures were used for these cells. The best energy conversion efficiency of 24˙5% has been demonstrated by a PERT cell on a MCZ(B) substrate. This is the highest energy conversion efficiency ever reported by a silicon cell made on a non-FZ substrate. All these cells have shown stable performances after a period of storage. The PERT cell structure has also considerably reduced the cell series resistance from higher resistivity substrates. A total rear boron diffusion in this PERT structure also appears to improve the surface passivation quality of MCZ(B) and some FZ(B) substrates. Hence, higher open-circuit voltages were observed for these PERT cells. It is also believed that these MCZ(B) and other SEH materials have considerably improved material qualities under SEH's current effort to develop high quality substrates particularly for photovoltaic applications. Copyright © 2000 John Wiley & Sons, Ltd.


Palabras clave: Histiocitoma, fibroso, atipico, pseudosarcomatoso. AbstrAct The fibrous histiocytoma shows several clinicopathological variants: aneurysmal, cellular, palisading, osteoclastic-like cells, clear cells, granular and atypical. Despite the benign behavior reported for fibrous histiocytoma some variants has shown tendency for recurrence and even to metastasize. We report a case of an atypical fibrous histiocytoma with sarco- ma-like features. Special care has to be taken regarding this type of tumours for avoiding aggressive and inappropriated excisions.


Credential revocation is a critical problem in grid environments and remains unaddressed in existing grid security solutions. We present our ongoing work in designing a novel grid authentication system, based on Globus GSI, that solves the revocation problem. The focus of this work is to ensure instantaneous revocation of both long-term digital identities of hosts/users and short-lived identities of user proxies. Our system employs mediated RSA (mRSA), adapts Boneh's notion of semi-trusted mediators to suit security in virtual organizations and propagates proxy revocation information as in Micali's NOVO-MODO system. We envision that our system would additionally provide a configuration-free security model for end users and fine-grained management of user credentials.


We use the simulation model of Chalfallt and Gallant (1985) to investigate the fit of a Fourier flexible form to a cost function when interest is to estimate elasticities of substitution. The data is subject to errors in variables and the estimation method is seemingly unrelated regressions. We use two approximating Fourier functional forms with 13 (FFF13) and 22 (FFF22) parameters. The biases in point estimation are negligible for FFF13. The classical t statistics do not follow, in general, the Student's distribution. Even when estimates are properly centered and scaled there are cases where the normal approximation does not hold.


Residential building energy efficiency in China has achieved certain efforts after 20 years of development. However, the implementation of the building energy-saving promotion is not effective enough. The paper discusses the current opportunity for the related industries brought by energy-saving buildings in China, meanwhile analyzes various challenges faced by the implementation of building energy conservation and takes a reference for the future.


This paper presents a theoretical model of collusion and regulation in a wholesale electricity spot market. Given a demand for electricity, competing generators report their marginal costs. Then, only generators with the lowest marginal costs are selected to sell at a price equal to the marginal costs of the last generator selected to sell. The results show that under a fixed price level it is a weakly dominant strategy to truthfully report the marginal cost. Variable (or endogenous) prices create the possibility of profitable collusion among generators. With uncertainty in the marginal costs and risk neutrality, the results show that a necessary condition for collusion to be sustainable is that the marginal cost reported by the pivot (marginal generator) should be higher than the average of the true marginal costs of all the generators. The existence of collusion fines and audit probabilities were found to be effective in deterring collusion. It is also shown that more efficient generators have less incentive to collude.


Data in this report are from the National Postsecondary Student Aid Study (NPSAS), a nationally representative sample survey. To learn more, visit http://nces.ed.gov/ surveys/npsas. For questions about content or to view this report online, go to http://nces.ed.gov/pubsearch/pubsinfo.asp?pubid=2016407. This report is based on data from four iterations of the National Postsecondary Student Aid Study (NPSAS), a large, nationally representative sample survey of students that focuses on how they finance their education. NPSAS includes data on federal Pell Grant awards, which are need-based grants awarded to low-income students, primarily undergraduates.


The first workshop, entitled "Good Manufacturing Practices for the Production of Shelf-Stable Acid, Acidified (Pickled) and Dehydrated Foods," will be offered at the Food Research Laboratory, at Cornell University's New York State Agricultural Experiment Station, in Geneva, NY, on October 6, from 8:30 a.m.-5 p.m. It will provide current and future small processors with the basic elements needed to understand the main processing steps, critical control points and record-keeping to safely manufacture specialty food products for the marketplace.


The author focuses on the problems of the woman resident and draws upon her own experience to illustrate her point that women are not accorded the same consideration as other minorities and that, for women, the residency period may be one of loneliness and misunderstanding. She observes that women have as much to learn from men as men from women and concludes that, if there are enough women staff members to make it possible, each woman and man in a residency program should have some personal supervisory experience with a woman staff supervisor.


The invention provides ravioli analogs. In one aspect, the ravioli analog comprises a first dough that completely encases a second dough, each of the first dough and the second dough having a different colorant relative to the other dough but at least one component of the first dough and the second dough being the same. In another aspect, a method for making ravioli analogs comprises co-extruding a first dough and a second dough having at least one component that is present in both the first dough and the second dough, the first dough and the second dough having different colorants relative to each other; and cutting the extruded doughs into pieces having predetermined sizes with ends sealed such that the first dough completely encases the second dough. In yet another aspect, a blended food composition comprises one or more ravioli analogs and one or more other comestible ingredients.


![Graphic][1]

Fewer abnormal blood vessels (green) grow beneath the retina after injections of young macrophages (top) than old cells (bottom).

APTE As they age, some cells simply fail to perform their jobs, but macrophages become troublemakers. According to Jennifer Kelly, Rajendra


Granules of the cement kiln ash potash is a kind of cement kiln ash as the main raw materials in recent years a new type of granular fertilizer. By the field experiment showed that in the mountains cold bad field applying potassium kiln dust granules on rice cultivation production effect is better than that of potassium chloride and potassium sulfate; Application of kiln ash between potassium granules and potassium chloride, potassium sulfate and potassium chloride and no significant difference between treatment; Applying potassium kiln dust granules and significant differences between potassium sulfate treatment; Compared with the control area without potash, three kinds of potash production have reached extremely significant level. Using potassium kiln dust granules production cost is low.


Illustrations are the important and indispensable part of scientific journal. Map of China is one of the representative and common map in scientific articles. Besides the criterion and science,more attention should be paid to the political issues that may damage the benefit of China. Main problems in the scientific journals can be categorized as territory loss,boundary error,Hong Kong,Macau and Taiwan related errors. Then,we analyze the reasons for these problems and propose the strategies and suggestions for authors. Meanwhile,we put forward some proposals for authors,editors and administrators of scientific journals and expect joint efforts from them to guarantee that the map of China is drawn correctly,which is of significance for improving the publication quality of scientific journals, and safeguarding national interest.


Sedimentation in dams' reservoirs is one of the most pressing concerns facing dams today. Maroon reservoir dam, located in Khuzestan Province, is one of the most important dams in this region. Since it is a new


CEREBRAL arteriosclerosis appears to be increasingly common, both relatively and actually, in relation to other conditions which produce psychoses. Pollock' has shown that in State Hospitals in the State of New York psychosis with cerebral arteriosclerosis has been constantly increasing, whereas other mental disorders are increasing very slightly or not at all. It is perhaps to be expected that as man lives to the fifth, sixth and seventh decades cerebral arteriosclerosis should become more common. It is also believed that the unusual increase in this disorder is due to strenuous mental and physical activity. There are men and women who at this time increase their worry and anxiety, and perhaps indulge in other excesses, when it is reasonable to assume that the individual should be living a somewhat less active life than in earlier decades. While overwork, worry and alcQhol are still considered to be important etiological factors in producing this disease, the last named factor assumes much less importance than was formerly attached to it. Many persons suffering from cerebral arteriosclerosis have been abstainers from alcohol, or have used it very sparingly. If alcohol is used to excess by a person who has also worked and worried to excess arteriosclerosis is more likely to result than when alcohol has not been used. Not all instances of cerebral arteriosclerosis are accompanied by mental symptoms, at least to the extent where special mental hospital care is indicated, but statistics do prove that in° relation to other mental disorders it is becoming one of the most common and serious forns of mental derangement. The symptoms which bring these patients to


The following research entitled DETERMINATION OF TOXOPLASMOSIS, USING TECHNOLOGY MICROPARTICLE CHEMILUMINESCENT IMMUNOASSAY (CMIA), IN PREGNANT PATIENTS ATTENDING A CLINICAL LABORATORY SERVICE "HCAM" "CARLOS ANDRADE MARIN HOSPITAL" IN THE PERIOD FROM NOVEMBER 2012 TO APRIL 2013, was executed with the aim of to do quantitative determinations IgG e IgM anti-toxoplasma real and reliable, that help the doctor to discard or verify Toxoplasmosis. During this investigative work revised bibliographic publications, also applied an inquest and also to perform the statistical analysis used as greater support the test result, of 100 pregnant patients that came to the clinical laboratory service the "Carlos Andrade Marin Hospital "located in Quito city


Hot Jupiters (HJs) are Jupiter-like planets orbiting their host star in tight orbits of a few days. They are commonly believed not to have formed in situ, requiring inwards migration towards the host star. One of the proposed migration scenarios is secular high-eccentricity or high-$e$ migration, in which the orbit of the planet is perturbed to high eccentricity by secular processes, triggering strong tidal evolution and orbital migration. Previous theoretical studies have considered secular excitation in stellar binaries. Recently, a number of HJs have been observed in stellar triple systems. In the latter, the secular dynamics are much richer compared to stellar binaries, and HJs could potentially be formed more efficiently. Here, we investigate this possibility by modeling the secular dynamical and tidal evolution of planets in two hierarchical configurations in stellar triple systems. We find that the HJ formation efficiency is higher compared to stellar binaries, but only by at most a few tens of per cent. The orbital properties of the HJs formed in the simulations are very similar to HJs formed in stellar binaries, and similarly to studies of the latter we find no significant number of warm Jupiters. HJs are only formed in our simulations for triples with specific orbital configurations, and our constraints are approximately consistent with current observations. In future, this allows to rule out high-$e$ migration in stellar triples if a HJ is detected in a triple grossly violating these constraints.


Simple Summary The present study evaluated oxidative and antioxidant status in dairy cows with Left Displacement of the Abomasum (LDA), an economically important postpartum disease in cattle. The oxidant capacity of plasma measured with a test fo reactive oxygen metabolites, the d-ROMs test, was significantly higher and the plasma biological antioxidant potential (BAP), measured with the BAP test was lower in the LDA group compared with the control group. Oxidative status was assessed using an arbitrary index obtained from the ratio between d-ROMs and BAP and the results showed that cows with LDA experience an imbalance between oxidants and antioxidants. Abstract Left Displacement of the Abomasum (LDA) is a condition that occurs in high-producing postpartum dairy cows and it causes economic losses. Studies performed in the last decade indicate that adult dairy cows experience oxidative stress. Increasing interest in the role of oxidative status in ruminant medicine has emphasized the need to develop reliable methods to assess it. A few studies have evaluated the relationship between LDA and oxidative status, mostly through the determination of single parameters of oxidation and the determination of antioxidant status separately, with contrasting results. The aim of this study was to assess the oxidative status by the measurement of Reactive Oxygen Metabolites with d-ROMs and Biological Antioxidant Potential BAP and the calculation of the Oxidative Status index in 74 multiparous dairy cows with LDA. Each case was matched with a control herdmate. The amount of free oxygen radicals in plasma samples was determined using the d-ROMs test, the concentration of antioxidants was measured using the BAP test and the Oxidative Status index was also calculated. The concentration of d-ROMs was significantly higher in the study group compared to the control group (179 ± 37.7 U CARR and 158 ± 23.0 U CARR, respectively), while the concentration of BAP was significantly lower in the study group than in the control group (2156 ± 98.1 µmol/L vs. 2558 ± 108.5 µmol/L). The Oxidative Status index value was significantly higher in cows with LDA than in healthy cows (8.3 ± 1.51 vs. 6.2 ± 0.76). The results of this study indicated that an inbalance between oxidants and antioxidants occurred in cattle with LDA.


A novel mechanical rotating grid flocculator was invented to enhance the coagulation and flocculation of surface water characterized by low temperature and low turbidity.A rotating grid flocculator with very small mesh grid was used to create vigorous micro-hydraulic condition at low energy consumption.This technology can adjust the micro-hydraulic condition to optimal state according to the variation of raw water quantity and quality.The efficiency of this technology for treating the source water of Mopanshan Water Treatment Plant was investigated.Experiments found that a significant enhanced coagulation was achieved at low energy consumption and appropriate rotating speed.A comparative full scale test was conducted with and without the mechanical rotating grid.The coagulant dosage when using the mechanical rotating grid was 19.6% lower than the dosage required without the mechanical rotating grid.


Part 1 Historical and analytical observations: general aspects Italy - dialogues based on the Old Testament - dialogues based on the New Testament - non-scriptural dialogues the Latin dialogue outside Italy the sacrifice of Abraham - six dialogues compared. Part 2 Transcription of 10 dialogues.


Introduction Oncolytic virotherapy is a promising form of gene therapy for cancer, using already existing "natural" agents - viruses. Tumor resistance to a lot of drugs after intensive chemotherapy is considered to be the main obsta-cle in curing cancer patients. Recent studies have shown that oncolytic viruses demonstrate a potential for effective treatment in a variety of cancer patients. Aim The aim of this work is to investigate the possible curative effect of the oncolytic poliovirus (PVS-RIPO) in patients with glioblastoma multiforme. methods PVS-RIPO is a genetically engineered polio virus which is infused directly into the patient`s tumor. Once in-side the tumor, PVS-RIPO infects and kills tumor cells. PVS-RIPO consists of a genetically modified non-pathogenic version of the oral poliovirus Sabin type 1. Although this tumor cell killing alone may have tu-mor-fighting results, the likely key to therapy with PVS-RIPO is its ability to recruit the patients' immune response against the cancer. The researchers have already achieved remarkable results in trials on animals, and may be on the verge of a completely new treatment for people. Currently, Phase I clinical trials of PVS-RIPO against glioblastoma are ongoing. For now this treatment is showing promising results by extending the life expectancy of patients with recurrent glioblastoma multiforme. Everything in the world of cancer treatment develops extremely fast these days. The key to better cancer treatment is a better understanding of the disease and the mechanisms that may work to fight it. is and to disclose information about any direct or other of to and this to overview the nature of the relationship between pharmaceutical companies and and HCOs, the existing practice for disclosure of transfers of from pharmaceutical companies to and HCOs, as well as the financial for Web-based of published scientific current legislative acts, as well as disclosed financial information by individual pharmaceutical companies. transfers of to as individual dis-closures, the as an aggregate amount in the case when the information could not be on an for the is to be for the and It provides analysis of the use of statins for treatment of to a great extent sets goals for the reduction of cholesterol in patients with high cardiovascular risk. Degenerative diseases are progressive destructive processes that leave lasting damage in the body. These are the most common articular damages. Degenerative bone diseases are caused by wear and tear of the joints in everyday life. They also cause fric-tion, which is highly painful. Knee and hip joints are affected. NSAIDs are among the most commonly used drugs in medical practice, the main indications for their application are: inflammatory joint disease, degenerative diseases and the like. Side effects of NSAIDs - those of the digestive tract (GIT), dyspepsia (nau-sea, vomiting), development of gastritis, ulcers or similar complications (bleeding, perforation, malignant degeneration). Given the accumulating evidence of adverse effects associated with chronic use of nonsteroidal anti-inflam-matory drugs (NSAIDs), which are the gold standard for the treatment of chronic inflammatory joint disease, it is necessary to develop safer therapeutic strategies for these patients. Medicines of natural origin are the first choice for prevention. They slow down the progressive nature of the disease, favorably affect the activity of the musculoskeletal system, and contribute to the strengthening and development of cartilage. there is a higher incidence of infections. Although not a traditional Bulgarian herb, Echinacea is quite popular in Bulgaria. The aim of this randomized clinical trial was to assess the protective effect of milk thistle seed extract against oxidative stress indices and hs-CRP in type 2 diabetes mellitus patients. Researchers the Iranian Diabetes Society and endocrinology clinics in East Azerbaijan recruited 40 people with type 2 diabetes to take part in the four-month randomized, placebo-controlled clinical trial. Patients were assigned to receive either a daily milk thistle supplement (200 milligrams three times per day) or a placebo (three times per day). The results showed that silymarin supplementation significantly increased superoxide dismutase glutathione peroxidase activity and total antioxidant capacity, compared to patients taking the placebo, by 12.85%, 30.32% and 8.43%. Insulin requirement, HbA1c levels, MDA levels were also decreased by 20%, 0.5% and 12.01% in the silymarin group. There was a significant reduction in hs-CRP levels by 26.83% in the silymarin group compared to the placebo group. Hs-CRP levels in type 2 diabetes mellitus patients are decreased by silymarin. The latter also has positive effect on antioxidant indices (SOD, GPX and TAC). the of the activity of The tested at a of The results showed that patients who received cineole recovered significantly faster than those given a placebo. Eucalyptus oil is said to function in a way similar to menthol by acting on receptors in the nasal mucous membranes, leading to a reduction in the symptoms of nasal congestion. Through digital imaging it was evaluated that the presence of Eucalyptus oil resulted in an increase in the ciliary beat frequency. The aim of this study was to compare the antihypertensive effect of the combination of zofenopril plus hydrochlorothiazide versus zofenopril monotherapy in patients with essential hypertension. hydrochlorothiazide for 12 in an international double-blind study. Systolic BP and DBP were measured by mercury sphygmomanometry, and changes associated with calculat-ed. hydrochlorothiazide may have a particular place in the treatment of high-risk or monotherapy-treated uncontrolled hypertensive patients requiring a more prompt, intensive and sustained BP reduction. Muscle relaxants are neuromuscular blockers that cause relaxation of the skeletal muscles. They represent nitrogen compounds with an affinity for N-cholinoreceptors. They are used in anesthesiology to induce a prolonged paralysis - a prerequisite for long lasting interventions. The nature of these drugs, improper dosing and clinical indications carry their appropriate health risks. Some muscle relaxants are an analogue of acetylcholine and thus easily bind to ACh receptors but, unlike them, they are not metabolized by the enzyme acetylcholinesterase. The occurring prolonged depolarization leads to muscle relaxation – hence the name depolarizing muscle relaxants. That includes suxamethonium chloride (succinylcholine), brand name Lysthenon. Application of this medicine is not recommended for patients with pulmonary edema, severe hepatic dysfunction, history of malignant hyperthermia, hyperkalemia and others. It may cause allergic reactions such as bronchospasm. Combination with other drugs suppresses or potentiates its action. In children and adolescents Lysthenon can cause irreversible cardiac arrest so its use is limited to cases in need of an immediate endotracheal intubation. The majority of non-depolarizing muscle relaxants are not metabolized by the ACh-esterase. They bind irreversibly to the cholinergic receptor and produce stoichiometric changes in it. Their metabolusm is not organ-dependent – the so-called Hofmann elimination. Intermediate metabolites may lead to side effects such as CNS hyperexcitability and seizures (Laudanozin toxicity). ), Doxacurium, etc. Usually in clinical practice a particular drug becomes universal and is used on many patients despite the existence of minimal clinical risks. Better understanding of muscle relaxants, their properties and side effects promises an optimal and safe use. Homocystinuria is an autosomal recessively inherited disorder of the methionine metabolism that leads to abnormal levels of methionine and homocysteine in the blood and urine. Homocysteine is metabolized to cysteine or methionine. The defect could be in the transsulfuration pathway that converts homocysteine to cysteine (homocystinuria 1) or in the methylation pathway (homocystinuria 2 and 3). The accumulation of homocysteine and methionine is caused by multiple defects. The 3 main causes are: The disorder leads to defects in the connective tissues, muscle tissues, the central nervous system, and the cardiovascular system. Depending on the type of homocystinuria the symptoms could be different but the most common ones are ectopia lentis, pes excavatum, pes carinatum, men-tal retardation, myopia, and cardiovascular problems. The physical symptoms could be deterio-rated by nutritional and environmental factors. Children with homocystinuria 1 (CBS deficiency) could be normal at birth but studies suggest that after the age of 20 the patients have an increased risk of thromboembolic events. Thromboembolism is the main cause of complications and death. Pyridoxine is the most common drug used for treatment. Patients are treated with pyridoxine in combination with folic acid and vit. B12. Some patients might be pyridoxine insensitive. In cases like that a low-methionine diet and betaine supplementation are recommended and might reduce the symptoms If the management of the disorder begins in time, severe complications could be avoied, so neonatal screening for homocystinuria must be mandatory in every country. Flavonols are class of naturally occurring compounds commonly found in vegetables and fruits. As a repre-sentative of them, quercetin has benefits in different aspects. The most important of them is its role as an antioxidant. It is believed to be an effective radical scavenger that can inhibit the oxidation of lipoproteins. This flavonol possesses an antiatherogenic property as well as an antihypertensive one. We performed a detailed review of related articles. The information that we found was objectively analyzed and systematized. The research showed that quercetin can prevent the development of atherosclerosis due to the protection against oxida


The outbreak of SARS-COV2 responsible COVID-19 disease created a worldwide health emergency After its first case was accounted for in 2019, 31st December by World Health Organization in Wuhan city of china, and afterward spreading in different nations, with India surpassing cases even the inception nation as on twentieth of May 2020 The WHO declared the disease as pandemic way back and countries over the world adoptinglockdown and contact tracing to limit the contagion The virus transmits person-to-person predominantlythrough respiratory routes through direct contact, droplets and possibly aerosols Because of the unique nature of practice in dentistry, most procedure generate significant amount of aerosols and droplets, posing a possible risk of infection transmission Understanding the concern of risk of transmission in dental practice, this literature is aimed to discuss the possible risk associated with practice and aim to raise awareness of the same with preventive measures especially after the lockdown end in day to day practice


In this paper we present a novel approach to datadriven fuzzy modeling which aims to create highly accurate but also easily comprehensible models. This goal is obtained by defining a flexible but expressive language automatically from the data. This language is then used to inductively learn fuzzy regression trees from the data. Finally, we present a detailed comparison study on the performance of the proposed method and an outlook to future developments.


Isotherms and isobars for polymer liquids using corresponding states principle to establish function describing dependence of internal pressure on volume or temperature


To minimize the energy consumption of an air-conditioning sub-system, we synthesized temperature sensitive hydrogel with temperature non-sensitive silicon gel. After changing the synthesis polymer ratio between the poly N-isopropylacrylamide hydrogel and the porous silica gel, the characterization of the synthesized polymer was obtained. The temperature sensitivity for different ratios of the synthesized gel polymer was made through solution polymerization. The polymer yield, water absorption, and the water discharge rate were observed using a differential thermal graph. This graph provided the details of the temperature response of water molecules. These gels were placed on glass paper soaked with acid for dehumidification system. The characterization of the temperature sensitive response for the synthesized hydrogel silica polymer was compared with the pure silica gel. Then, we put forward the concept of critical temperatures for the synthesized polymer and discovered that it had similar physical meanings of lower critical solution temperatures of the pure hydrogel. Based on this new finding, we were able to use the synthesized polymer to modify the desiccant dehumidification system. As a result, we reduced the cost and improved performance by using the optimized synthesizing ratio.