An elegant breadboard model of the LISA phasemeter is currently under development by a Danish-German consortium. The breadboard is build in the frame of an ESA technology development activity to demonstrate the feasibility and readiness of the LISA metrology baseline architecture. This article gives an overview about the breadboard design and its components, including the distribution of key functionalities.


. We propose a cosmological scenario involving a scalar field, ϕ , that is a source of Dark Matter as well as of Dark Energy. Besides ϕ , the Lagrangian of the field theory envisaged in our scenario contains a second field χ , for simplicity assumed to be a scalar, too. For fixed values of χ , the potential term decays exponentially at large positive values of ϕ . While ϕ is not coupled to Standard Model fields, χ is assumed to be coupled to them, and the Green functions of χ depend on the cosmological redshift in the expanding universe. We assume that the term in the Lagrangian coupling χ to ϕ is such that, at redshifts z larger than some critical redshift z c , ϕ is trapped near ϕ = 0, and oscillations of ϕ about ϕ = 0 describing massive scalar particles give rise to Dark Matter. At redshifts below z c , the field ϕ is no longer trapped near the origin and starts to "roll" towards large field values. A homogenous component of ϕ emerges that acts as Dark Energy. Within over-dense regions, such as galaxies and galaxy clusters, the redshifting of χ stops, and ϕ therefore remains trapped near ϕ = 0 as long as z c is smaller than the redshift when structures on galactic scales decouple from the Hubble flow. Thus, at the present time, ϕ describes both Dark Energy and Dark Matter.


In his introduction to Muni Punyavijaya's edition/ of the important Prakrit manual of divination, the Angavijjd, Dr. Moti Chandra made some preliminary attempt at commenting on its varied contents. On page 42 he commented on the passage 9, 270 ff, calling it a 'List of Goddesses,' which should perhaps be slightly modified. In 9, 270 a general definition, amdnuse sadde, 'non-human female beings' is given. The text goes on listing such female beings, but the end of it seems to consist purely of names of Apsarases. I quote the whole passage and Moti Chandra's comment on it:


Director Julie Taymor and her partner, composer Elliot Goldenthal, collaborated on two location-shot Shakespeare films: Titus (1999) and The Tempest (2010). The freshness of the collaborators' cinematic approach to Shakespeare is in part a consequence of their having also worked extensively together in the theatre (including stage productions of these two plays, and a filmed theatrical performance of A Midsummer Night's Dream released in 2015) and their refusal to eschew dramatic stylization on the silver screen in favour of a populist realism. The eclectic music for Titus ranges from choral incantations to distorted jazz idioms, dynamic minimalism, searingly expressive orchestral writing, mesmerizing electronics, and a black-comedy application of carnival music familiar from the collaborators' stage work; almost all the music is foregrounded, yet little attempt is made to endow this powerful composite score with the specious unifying function traditionally demanded of film music. By contrast, the score to The Tempest is more subliminal in its effect, while still experimental in its exploration of soundscapes which shift from Caliban's 'thousand twangling instruments' to sparse ideas expressed in novel guitar tunings and sonorities, evocative keyboard timbres, saxophone multiphonics, glass armonica, and steel cello. Above all, the film's soundtrack is distinguished by its contemporary response to the play's songs, which here include an additional lyric borrowed from Twelfth Night in order to enhance the romantic subplot, and the climactic isolation of the (female) Prospera's epilogue in the end credits.


The aim of this thesis is to study the anthropology of contemporary Swedish ecotheology and theology of creation, Bo Brander, Per Larsson and Wilfrid Stinissen, in comparison with the ecofeminist theology of Sallie McFague. The Swedish theologians in this study describe man as steward, microcosm, priest, co-sufferer and the image of God. McFague use the term partner when describing man, a term which is connected to the responsibility of man, but also the fellowship between man and God. The relationship between man and creation is by all theologians in this thesis described by both pointing to the responsibility of man but also the love and the mutual relationship between man and creation. Man is responsible in relation to the real Owner of the world, therefore man is in his relationship with God both a steward and a mediator. The contribution of McFague is her focus on the body, both creation as made up of bodies but also the view of the world as the body of God. This is also one of the strongest connections between Stinissen and McFague. McFague also focuses on the importance that man know who he is, and to know (in both sense of the word) the place in which he lives. Man, according to ecotheology is in a double relationship. He is the image of God and steward/partner of God and as someone who is created, is part of Creation with his place in and with the rest of creation.


This presentation gives an introduction to Resource Description and Access (RDA). The author presents information on how RDA works, its affects on cataloging and its functionality.


This Thesis is brought to you for free and open access. It has been accepted for inclusion in Dissertations and Theses by an authorized administrator of PDXScholar. For more information, please contact email@example.com. Recommended Citation Priest, Barbara, "Preliminary inventory of lifeline systems and evaluation of seismic hazards in Reno and Sparks, Nevada" (1981). Dissertations and Theses. Paper 3187.


This study demonstrated how Multisample Structural Equation Modeling can be used to statistically test the generaliability of findings across lab and field studies. This study is embedded in the context of attribution theory, as previous research has substantiated a model of cognition-emotion-behavior responses. The statistical test of generalizability serves as a companion to "practical" significance tests forwarded by others.


We prove that there are no Kähler structures on exotic tori. This yields a negative solution to a problem posed by Benson and Gordon.


IS transformation projects involve numerous exchanges between people inside and outside the project team. These projects constitute unique opportunities to integrate knowledge, i.e. to share, create and institutionalize new organizational knowledge. The focus of this research is to understand the knowledge integration process and to study the influence of the social capital of the project team. We carried out two exploratory case studies of ERP projects in SMEs, using a qualitative methodology for both data collection and data analysis. The results show that three closely linked and intertwined phases (namely Collection, Interpretation and Assimilation) constitute the knowledge integration process where interface integrators play a key role. We also show the common influence of the structural, relational and cognitive dimensions of social capital on the three phases of knowledge integration. Finally, we consider the dynamics of internal and external facets of social capital to be particularly relevant in the context of a project. Given that ERP implementation is more and more important for SMEs, our research underlines the structuring role of the project team in this process and highlights the importance of managing knowledge within the project team.


Adaptability of buildings has become an important issue in building life relying on the flexibility in the future use of space to extend the functional lifespan of systems. The main findings for this work are based on a case study analysis of the Kyoto House designed and built in Barcelona by Pich-Aguilera Architects. Three core aspects for this research are: 1) energy efficiency and economy; 2) flexibility-adaptability-transformation-customization aspects of building structure; 3) industrialization and industrialized systems. Kyoto house is the first industrialize concrete house that combines the concrete load-bearing structure with sustainable systems for energy efficiency. The building structure is designed and built as an open systems' configuration model. All systems and components are parts of one integrated configuration model arranged according to the main building functions (load-bearing, enclosing, partitioning and servicing). The systematic approach is introduced for an assembly of different structural elements according to independent technical and functional levels. Systematization of industrialized components into independent levels takes into account that different parts of the building have different life span and functional expectances, as well as different assembly procedures. The key aspects of sustainable construction are in the house ability to be dismantled where the systematization and the hierarchy of components and subsystems support total configuration disassembly. Finally the aim of this paper is: a) to identify, analyze and map the phenomenon of open systems' configurations model; b) to describe the main characteristics of Kyoto House building structure; c) to improve the house capacity to adapt to spatial and technical changing requirements and consequently extend the service life of the building in the future.


This  paper present the concept of the outlier mining, discussed using  Euclidean  distance-based outlier mining to analyse the expressway toll to anti-defrauding, for to illustrate it, gived the example of toll collection's  man-day and  nullah, analysed the toll collection data in Microsoft SQL Server, helped the toll check man to find outlied data, via emphases check on those outlier data, can fing the evidence for anti-defrauding; can offer proofe chain  to treat with the defrauding things, this paper also analysed the strongpoint and the shortcoming of using the  algorithms  of  Euclidean distance-based outlier to analyse the defrauding in highway toll collection.


Water storage availability of semiarid regions is closely linked to the snow reservoir and its changes. The change of hydrological regime in mountain rivers is strongly affected by the snowpack's dynamics, which plays a crucial role during spring and/or summer season in Mediterranean areas, becoming one of the major water sources to streamflow. This influence can be analyzed from different approaches; however, due to the concurrence of different processes, whose interaction and propagation undoubtedly affect runoff and baseflow generation, a processoriented approach is required for further understanding the ultimate reasons behind the observed changes. Hence, the partitioning of river flow into baseflow, subsurface flown, and runoff, is a key step in hydrograph analysis and for better understanding snowfed rivers and how climate variability can influence their regime.


Uveitis describes a group of disorders characterized by intraocular inflammation. Many uveitic conditions are presumed to have an autoimmune etiology and are treated with immunosuppressive drugs, including cyclosporin A (CsA).'.' The National Eye Institute is conducting a phase II clinical trial of oral tolerance as a treatment for uveitis.' In this study, patients with stable disease on immunosuppressive medications are fed with retinal antigens and then have their immunosuppressive medications discontinued. Some of these patients are taking CsA when feeding of retinal antigens is begun. We therefore decided to study the effect of CsA on the induction of oral tolerance in experimental autoimmune uveitis (EAU), an animal model for human uveitis.'


This study investigated French and American perceptions of violence. The participants were 100 undergraduates at the University of Wisconsin – La Crosse, Wisconsin, USA, and 190 undergraduates from the University of Caen, France. Participants completed a survey which assessed appropriateness and intensity of response to a scenario describing an assault situation. The nationality of the perpetrator was manipulated (American – French) as well as the precipitation (provoked – unprovoked). Results were analyzed with MANOVA and post-hoc ANOVAs, and reveal no significant main effects for gender and nationality of perpetrator, with regard to perception of normalcy of response and degree of response. Results suggest that all participants, regardless of nationality, viewed the perpetrator response as more inappropriate and unnecessary when there was no clear provocation. A significant interaction was found whereby the French participants rated perpetrator response as overly intense regardless of provocation; Americans held a similar view only for the unprovoked scenario.


A 30-year-old man presented to our clinic with anterior pain and functional limitation of the left hip for the last two months. The pain had been constant (Numeric Rating Scale: 6/10), and more severe when playing football and climbing the stairs. This article is protected by copyright. All rights reserved.


Characterization of the steady state kinetics of re- duction of horse ferricytochrome c by purified beef ubiquinol-cytochrome c reductase, employing 2,3-dimethoxy-5-methyl-6-decylbenzoquinol as reductant, has shown that: 1) the dependence of the reaction on quinol and on ferricytochrome c concentration is con- sistent with a ping-pong mechanism; 2) the pH opti-mum of the reaction is near 8.0; 3) the effect of ionic strength on the apparent K,,, and the TN,, of the reaction for the native cytochrome c is small, and at higher cytochrome c concentrations substrate inhibition is observed; 4) the effect of ionic strength on the kinetic parameters for the reaction of 4-carboxy-2,6-dinitrophenyllysine 27 horse cytochrome c is much larger than for the native protein; and 5) competitive product inhibition is also observed with a Ki consistent with the binding affinity of ferrocytochrome c for Complex 111, as determined by gel filtration. In addi- tion, direct binding measurements demonstrated that ferricytochrome c binds more tightly than the reduced protein to Complex I11 under low ionic strength conditions and that under these conditions more than one molecule of cytochrome c is bound per molecule of Complex 111. Exchange of Complex 111 into a nonionic detergent decreases this excess nonspecific binding. and I11 by was


Berkeley's theory of mind has not, in the general run of things, commanded much respect. In fact, it has, more often than not, been perceived as an embarrassment. For, even though he claimed to have shown that our knowledge can extend no further than our ideas and that there can be no justification for talking about material substance, Berkeley insisted on the existence of spiritual substance. Because he refused to draw the conclusion that we have no better evidence for the existence and nature of spiritual substance than we do of material substance, Berkeley has repeatedly been charged with holding a position that is sadly incoherent. Reid's reaction is typical. In Essays on the Intellectual Powers of Man (II, XII),' he writes:


Tenuipalpus orchidofilo n. sp. (Acari: Tenuipalpidae) is described from Brazil based on the mobile immatures and adult stages of both sexes collected on the orchid Arundina graminifolia (D. Don) Hochs.


This paper proposes a novel control system for synchronous machine rotor speed control. Based on deterministic observer and cascaded loops, a linear control system is obtained. Stability proof of the observer and linear analysis of the control system is given. Simulation studies of the machine starting, speed reversal and step loading are presented. A Comparison Analysis with the nonlinear control method, is also presented.


AbstractThis descriptive study reports the extent of sexual harassment between North Carolina high school students and teachers and suggests procedures for recognizing and ending those improper relationships. Although the majority of research about sexual harassment in an academic setting has been performed on college campuses, the problem has been experienced in secondary education. To assess the current environment, I surveyed 140 North Carolina school superintendents and 300 high school seniors. The data revealed a discrepancy between the number of faculty that the superintendents reported as having been disciplined for sexual harassment of a student and the number of students who believed that they had experienced sexual harassment. A structure for establishing guidelines to prevent teacher-student sexual harassment is presented.


The ACI Code equation for the ratio of spiral reinforcement is modified to account for the level of eccentricity of applied loads. The available ductility ofspirally confined reinforced concrete column sections, with a range of longitudinal and transverse steel ratios, strengths of steel and concrete, and also different ratios of eccentricity level-to-section diameter are studied. The method of analysis is based on a theoretical study using a unified stress-strain model for concrete subjected to uniaxial compressive loading and confined by transverse reinforcement proposed by Mander et al. The steel stress-strain model includes strain hardening. It is concluded that the current ACI Code requirements for transverse reinforcement are low at high eccentricity levels and high for axially loaded columns. Based on this theoretical study a modification is proposed of the ACI requirements that involves adding a term, a function of the eccentricity-to-column diameter ratio multiplied by the original ACI expression for spiral steel.


Between Colliding Worlds: The Ambiguous Existence of Government Agencies for Aboriginal and Women's Policy, Jonathan Malloy, Toronto: University of Toronto Press/IPAC, 2003, pp. x, 217. This book explores the complex relationship between "special policy agencies" created to address the needs of specific social groups, and the social movements that arise to advocate for these groups. Its main premise is that special policy agencies exist in a state of permanent—and highly useful—ambiguity, forming a conduit that enables the conflicting worlds of social movements and governments to articulate their highly distinct agendas in a manner comprehensible to both "worlds."


The invention discloses a formwork jacking tool for constructing a post-cast strip of a cast-in-place slab and a formwork supporting construction method. The formwork jacking tool for constructing the post-cast strip of the cast-in-place slab comprises a jack, an adjustable supporting nut, at least one bracket and an adjustment nut. The jack comprises a screw and a supporting plate A arranged at the top end of the screw, wherein nail holes are formed in the supporting plate A. The adjustable supporting nut comprises a nut body, wherein two supports are symmetrically arranged on the outer side of the nut body, sliding grooves which are arranged in the axial direction of the nut body are formed in the supports, and a U-shaped clamping ring which is connected with the corresponding support is arranged on the outer side of each sliding groove. Each bracket comprises a dorsal rib which is in the shape of a right trapezoid, a supporting plate B is fixed to the big end of the right-trapezoid-shaped dorsal rib, and sliding rails are arranged on the two side faces of the dorsal rib respectively. The brackets are connected with the sliding grooves in the supports in a matched mode through the sliding rails, the U-shaped clamping rings are matched with the oblique edges of the dorsal ribs of the brackets so as to fasten the brackets, the adjustable supporting nut is connected with the screw of the jack in a matched mode through the nut body, and the adjustment nut is connected to the lower portion of the screw through threads.


This paper analyses Willi Hennig's viewpoint on the information brought by palaeontology in connection with phylogeny reconstruction. This analysis is mainly based on two books, Phylogenetic Systematics and Die Stammesgeschichte der Insekten (Insect Phylogeny) where the treatment of four topics is detailed: (1) the use of fossils for phylogeny reconstruction; (2) the insight of paleontological data on the theory of phylogenetic systematics; (3) the insight of phylogenetic systematics on theories dealing with evolutionary processes; and (4) the classification of fossils in the phylogenetic system. The connection between cladistics and palaeontology has been a source of conflicts up to the recent years. But Hennig did not minimize palacontological information, even if his definition of the criterium of geological precedence'' does not put palaeontology as the science of phylogenetics per se. Persistence of conflicts are due to three sources: the misunderstanding by paleontologists of the notion of age of taxa; cladistic critics of evolutionary methods which were understood as critics of palacontology as a discipline (an aspect connected to the confusion between pattern and process); post-hennigian cladistic litterature, especially in the english-speaking circles. sometimes different from Hennig's own views, It is also emphasized that Hennig, with a palacontological example, discussed the question of the relation between process (mode of evolution) and character analysis in terms that anticipate modern debates on the connection of evolutionary models with parsimony analysis, especially in the molecular field.


The aim of the topic is to teach students how to asses their own progress . Self-evaluation is a potentially powerful technique because of its impact on student performance through enhanced self-efficacy and increased intrinsic motivation.To use other explicit criteria of evaluation. Self-evaluation is defined as students judging the quality of their work, based on evidence and explicit criteria, for the purpose of doing better work in the future. Alternate forms of assessment can generate that other information.We explore the research and practice related to student self-evaluation. The new: Evidence about the positive effect of self-evaluation on student performance is particularly convincing for difficult tasks, especially in academically oriented schools and among high need pupils . Perhaps just as important, students like to evaluate their work.The help will give: Teachers today are experimenting with alternatives to traditional tests. Performance assessment, portfolio collections, classroom observation, peer assessment, and self-evaluation are joining the unit test and the final exam in the repertoire of the skillful teacher. Such teachers ensure that an over-reliance on testing does not seriously distort instruction or impede important school improvement efforts. Accordingly, their programs are based on a range of assessment approaches. Teachers who include authentic assessment in their repertoires are driven by a belief that curriculum-assessment experiences should prepare students for life in the real world. DOI: 10.5901/jesr.2013.v3n7p431


Voice recognition technology is the process of identifying and understanding the voice signals of a user, which is converted into text or commands for a program. In this work the voice recognition technology is applied into a laboratory information system for identifying each technician's voice. i.e. By using the user's voice sample, a secure authentication system is developed where the unique features of the user's voice are extracted and stored at the time of registration. Afterwards during the login stage, unique features of the user's new voice sample are extracted. Then compare the features with all the stored features rather than the just previous one. For this, a unique username is set to all the users. The comparison operation is performed with all voice samples under that particular user name. The voice feature comparison process is done by using Fast Fourier Transform techniques. After a successful login the user can enter the results of smear test through his voice rather than typing into the system. The system mainly consists of two parts a client system and a server system. The client system is developed using Android and the server system is implemented in Java.


The most relevant studies about the effect of communication departments in the mass media are reviewed, especially those concerning the press release. It has been noted that the number of press releases sent by different organizations has increased over the years, and so has the documents which are eventually published. As a consequence, journalists produce fewer original stories. Not only do they publish more press releases, but they also maintain the order of the ideas and they rarely complete the data with other files or consulting other sources of information.


The walls of the first level of the building often exhibit moisture problems as a result of exposure to rain and water absorption in the soil by the foundation wall. Unfortunately, conventional concrete blocks, purchased on the market and used as foundation wall, have a high coefficient of capillary suction and a low resistance to water penetration. In this research, concrete blocks and cylinders were produced and analyzed experimentally. They were manufactured with washed concrete sand, type I Portland cement, cold bitumen emulsion and a 0,40 water-tocement (w/c) ratio by weight. Blocks and cylinders were analyzed first without the addition of bitumen emulsion and then with the addition of 10 %, 20 %, 30 % and 40 % of bitumen emulsion by weight of the cement. Capillary water absorption test, resistance to water penetration test and compressive strength test were completed. A comparative analysis of the results was performed in order to determine the optimum addition of bitumen emulsion. It was determined that the blocks with bitumen emulsion have better properties than conventional blocks without additives. Furthermore, it was concluded that the blocks with cold bitumen emulsion reduce moisture problems in the walls since these blocks have a low coefficient of capillary suction.


The present invention has disclosed a kind of Ni Taidani (Nintedanib, I) preparation method, its preparation process comprises: 4-(acetic acid R ester-2-yl)-3-nitrobenzene methyl (II) obtains (E)-4-[(2-methoxybenzene methylene with former benzoic acid trimethyl generation condensation reaction) acetic acid R ester-2-yl]-3-nitrobenzene methyl (III), under the effect of acid binding agent, there is substitution reaction with N-(4-aminophenyl)-N-methyl-2-(4-methylpiperazine-1-yl) acetamide (IV) and generate (Z)-4-{[2-(N-methyl-2-(4-methylpiperazine-1-yl) acetamido aniline) benzylidene in compound (III)] acetic acid R ester-2-yl }-3-nitrobenzene methyl (V), compound (V) makes Ni Taidani (I) through reduction and ring-closure reaction successively. this preparation method's raw material is easy to get, and technique is succinct, and economic environmental protection is applicable to suitability for industrialized production.


The B_s^0 differential production cross section is measured as functions of the transverse momentum and rapidity in pp collisions at √s=7  TeV, using the B_s^0→J/ψϕ decay, and compared with predictions based on perturbative QCD calculations at next-to-leading order. The data sample, collected by the CMS experiment at the LHC, corresponds to an integrated luminosity of 40  pb^(-1). The B_s^0 is reconstructed from the decays J/ψ → μ^+μ^- and ϕ → K^+K^-. The integrated B_s^0 cross section times B_s^0 → J/ψϕ branching fraction in the range 8 < p_T^B < 50  GeV/c and |y^B| < 2.4 is measured to be 6.9±0.6±0.6  nb, where the first uncertainty is statistical and the second is systematic.


There is no doubt that public finance and accounting have been playing a pivotal role in supporting the government's aspirations in the development in any countries. Through the receipt of funds from the state budget, the organizations in the public sector use country's resources towards the implementation of objectives as well as social policies set by national government. Therefore, most countries will aim to gradually improve the management of public finance, but control of public finance has faced challenges because of the existing limitations. As a result, the public finance management needs to be reformed. In Vietnam, this process has been performed in recent years. To enhance the effectiveness of improvement, public finance has to combine with the transformation of public sector accounting. In fact, there are a lot of researches in public sector accounting together with financial management. However, in the world, from the past to present, very little research has been conducted to examine the change in management to the public finance and relationship to public accounting, especially to the model of general accounting. Because of the significance of above matters, the main purposes of this paper are to identify the role of public finance and the process of reforming it and to build up the new model in Vietnam, called as General State Accounting (GSA) which is applied for Vietnamese government in the near future. By using the mixed method for research, the author will analyze the figures of last budget data, administer the described statistics, and collect information about the budget from Vietnamese experts.


The oxygen consumption of isolated segments of 40 human umbilical arteries was measured at different temperatures from 5 °C to 37 °C with a modified Fenn microrespirometer. The values varied from 8 μl/g per h at 8 °C to 70 μl/g per h at 37 °C. The Arrhenius plot was nonlinear, and the Q10 varied from 0.11 (30–40 °C) to 1.8 (20–30 °C) and 7.1 (10–20 °C). This suggests that the metabolic processes may be different at high and low temperatures. The results were consistent for at least 5 h post partum, and did not seem to vary from one segment of the cord to another.


With the rapid development of the business,the system construction of telecom operators are also in full swing,room refrigeration and energy-saving issue has become a major problem restricting the development of enterprises.The article expound from the practical problems faced of the data center,pertinently put forward to technical proposal of solving room refrigeration and realizing energy-saving,and starting from specific practice of china mobile group neimenggu Co.,Ltd.,expounding the value and extensibility of the technical proposal.


Background: Dinh Lang [Polyscias fruticosa (L.) Harms] is a medicinal plant widely grown in Vietnam, with proven note-worthy health benefits. However, Dinh Lang's amounts of triterpenoid saponins could not meet the need of the pharmaceutical industry. Thus, this study's purpose is to figure out the optimal condition for raising Dinh Lang's cell biomass, rhizogenesis and somatic embryogenesis to provide materials for bioactive compound productions. Methods: Different 2,4-dichlorophenoxyacetic acid and α-naphthaleneacetic acid concentrations (0.5, 1.0, 1.5 and 2.0 mg/L) were examined to determine the best amount of each plant growth regulator for raising cells' biomass, rhizogenesis and somatic embryogenesis. In each treatment, two grams of eight-week-old calli were cultured in 50 mL of liquid MS medium. Result: It is demonstrated by the results that liquid MS medium containing 1.5 mg/L α-naphthaleneacetic acid has the capacity of producing the highest numbers of somatic embryos (489 embryos per flask) and rooted cells (259.5 cells per flask), while the fresh weight of cells cultured in the medium given 1.5 mg/L 2,4-dichlorophenoxyacetic acid reached its peak of 5.7 g.


The flow standards NetFlow/IPFIX are available in many packet forwarding devices permitting to monitor networks in a scalable fashion. Based on these potentials, flow-based intrusion detection became more pronounced as it can be seamlessly integrated with respect to operational aspects. Exploiting these flow exporting techniques, recent years revealed promising research results, but mainly focusing on point solutions such as botnet or brute-force detection. Only few attempts tried to endeavor a general flow-based intrusion detector, and thus little is known about meaningful flow features and their ability to classify various attack types efficiently. In this paper, we work towards these challenges and seek for valuable features derivable from NetFlow/IPFIX data using Rough Set Theory. Moreover, the combination of flow features and log events is studied to further boost accuracy. Employing Machine Learning techniques, results show the obtained feature sets detect classic and modern attacks.


The invention discloses a maximum power point tracking device of a marine photovoltaic power generation system, comprising a BOOST circuit, an output control circuit, a voltage detection circuit, a current detection circuit, a PWM (Pulse-Width Modulation) drive circuit, an output voltage detection circuit and a controller. The controller receives real-time signals from the voltage detection circuit, the current detection circuit and the output voltage detection circuit, and tracks the maximum power point of the system by controlling the duty ratio of a switch tube S1 in the BOOST circuit with a specific tracking control algorithm. The maximum power point tracking device has the beneficial effects that the device solves the problem of misjudgment caused by shock, shake and large sunshine fluctuation in the navigation process of ships; the maximum power point can be tracked realized rapidly, stably and accurately, and the adaptability is strong; and compared with the current similar controllers, the device is low in cost and simple in structure.


The fungi (sing. Fungus; L.) are heterotrophic organisms of very diverse form, size, physiology and mode of reproduction. The ancient Greeks and Romans, and surely their less civilized contemporaries, were fond of truffles, mushrooms and puff balls. Mushrooms became such delicacies that they were only food which wealthy people insisted on cooking themselves. Cases of accidental mushroom poisoning were also known to ancient Greeks and Romans as early as 500 B.C. The name "evil ferments of the earth" was given to some of the mushrooms. The edible members were called "mushrooms" while the poisonous varieties were termed "toadstools". The Roman emperor Cladius Caesar (A.D. 54) was murdered by his wife who mixed his food with Amanita phalloides. Sporophores of mushrooms were popular among the Roman potters and sculptures. A series of ancient stone sculptures (1000 B.C.200 A.D.) bearing designs of mushrooms have been collected by Wasson and Wasson (1957) from Guatemala and other Central American countries (Dube 2004).


In the last eight decades the number of actors actively involved in global governance has dramatically increased, convincing large sections of the population that international institutions are now the driving engine of economic, political, and social policy all over the world. With international organizations such as the UN, NATO, and the IMF claiming to tackle efficiently the poverty, underdevelopment, peacekeeping, and security issues of the planet, it would seem that Harry Truman was right to believe in the following lines:


Abstract Diabatic and latent heating profiles from four global reanalyses and three Tropical Rainfall Measuring Mission (TRMM) algorithms were compared: first generally for the tropics and then in the context of the Madden–Julian oscillation (MJO). Most of them exhibit three heating maxima corresponding to known convection centers over South America, Africa, and the Indian–western Pacific warm pool, but they still differ substantially in many ways. Most noticeably, a double-peak vertical structure with one peak in the upper and the other in the lower troposphere and relative weak heating over the Maritime Continent in comparison to heating over the Indian and western Pacific Oceans are clearly seen in some heating data but absent in others. Heating profiles associated with the MJO were diagnosed through composites and case studies. The composites were constructed as functions of MJO phases at three longitudes representing the Indian Ocean, Maritime Continent, and western Pacific, respectively. Four MJO ev...


This paper describes the strong and sustained growth in natural gas vehicles (NGV), focusing on the dual-fuelled diesel engine concept and how this system has and will meet the needs of the heavy-duty transport sector. Significant development in gas extraction, delivery, engine and vehicle technology are discussed. Detailed information relating to dual-fuel IC engine strategies for US2010 and Euro VI are presented and discussed. The paper gives a clear overview of the global NGV scene and explains how dual-fuel technology offers a pragmatic and attractive solution to the heavy transport sector in its adoption of natural gas as a road-fuel.


The effect of flow asymmetry was observed experimentally in vertical parallel channels of a continuous direct ohmic heater. While downward-oriented flow is evenly distributed at isothermal conditions, the flow rate in parallel channels differs in the case of heating due to buoyancy effects. Three different configurations of parallel flow (with and without internal heating in channels) are analyzed, giving critical values of Gr/Re or Ri = Gr/Re2 and ensuring stable and even distribution of flow into parallel channels of vertically oriented heat exchangers or heaters. Experimental verification was based upon flow visualization (injection of a colored tracer and monitoring the tracer by a camera), measurement of temperature profiles, and stimulus response experiments using KCl as a tracer for conductivity methods (2 Pt conductivity probes) and Tc99 as a radioisotope tracer (collimated scintillation detectors).


A method for modifying a window with a frame associated with an audio signal is described. A signal is received. The signal is partitioned into a plurality of frames. A determination is made if a frame within the plurality of frames is associated with a non-speech signal. A modified discrete cosine transform (MDCT) window function is applied to the frame to generate a first zero pad region and a second zero pad region if it was determined that the frame is associated with a non-speech signal. The frame is encoded. The decoder window is the same as the encoder window.


Abstract Disclosure: U.S. Durrani: None. A. Paracha: None. S. Vasireddy: None. F. Waheed: None. M. Thomure: None. Prolactinomas are tumors of the pituitary gland that induce hyperprolactinemia. Symptoms at presentation can include growth delay, infertility, neurologic deficits and bothersome galactorrhea. Dopamine suppresses prolactin production; therefore, dopamine agonists are first-line treatment for prolactinomas. However, hyperdopaminergia is also associated with psychiatric disorders. The dopamine hypothesis states that cerebral hyperdopaminergia can contribute to symptoms of schizophrenia. Thus, psychiatric disorders are commonly treated with dopamine antagonists. Almost 1 in 8 people in the world have a psychiatric condition. It is almost inevitable that the medical system will have to treat patients with both a psychiatric condition and a prolactinoma; thus, it is essential to identify treatment regimens for these patients. In order to identify potential treatments, we conducted a PubMed literature search focusing on patients with prolactinomas and co-existing psychiatric diagnoses. Our inclusion criteria helped us focus on patients who presented with concurrent prolactinoma and psychiatric condition which were confirmed by brain imaging, serologic prolactin levels, and reports of psychiatric conditions/episodes in their medical history (or chart). Our search yielded 30 studies representing a total of 54 patients with both conditions. We found that four key themes emerged from the literature: 1) discontinuing risperidone in exchange for other atypical antipsychotics such as aripiprazole, olanzapine or ziprasidone, 2) discontinuing thioridazine, thiothixene and remoxipride in exchange for clozapine, 3) dopamine agonist therapy cessation to abate psychiatric symptoms, and 4) surgery and/or radiation after pharmacotherapy. In conclusion, we would recommend focusing on specific antipsychotics (aripiprazole, olanzapine, ziprasidone, or clozapine) while shying away from (risperidone, thioridazine, thiothixene, and remoxipride). We would also recommend ceasing dopamine agonist therapy at least until symptoms improve. If these two methods are not yielding sufficient results, then pursuing surgical options or radiation therapy may be considered. Presentation: Friday, June 16, 2023


The study investigates the relationship between outward foreign direct investment (OFDI) and economic growth of India using time series data covering the period of 1990–2019. It develops three models, including variables such as OFDI, economic growth, inward foreign direct investment, exports, and gross fixed capital formation. It applies non-linear ARDL approach and uses GDP per capita as proxy of economic growth. Broadly, it finds a positive long-run and short-run bi-variate relationship between OFDI and economic growth of India. But with the introduction of domestic fixed capital formation variable, the relationship turns negative. The study recommends the policymakers to focus on country's gross fixed capital formation and invite investments from abroad, rather than directing funds to foreign countries.


The relation of employee-employer is of the typical co-existence.The type of the above said relation is of three factors such as co-existence of unit,of mode and of environment.Among these relations the relation of employee-employer is the key of industry and harmony degree.The improvement relation of employee-employer is the result of change of co-existence relation.It is,therefore,that to promote continuation of co-wealth is the necessary choice to co-existence and the win-win to construct enterprise and harmonic labor relation and enterprise advance.


Kulay archeological culture with developed bronze casting manufacture was formed at the beginning of the Early Iron Age in the forest territory of West Siberia. Its cultural identity was expressed in specific forms of religious metal casting, armament supplies and ceramics. The socio-economic structure of the society bore insular nature at the Early Vasygan stage of Kulay culture. The main focus of foreign economic relations was bronze import. The homogeneity of the industrial organization of Early Kulay society was determined by its cultural isolation, not receptive to foreign innovations. The low level of development of productive forces and production relations, narrow technical base, traditional character of Early Kulay metalworking techniques were typical for simplest forms of work organization home production. Requirements in metal products were met within the patriarchal family. Mastering of nonferrous metalworking skills by the community masters occurred gradually, through trials and errors, upon receipt of metal in the environment of the forest population. Therefore, casting defects can often be found among the Early Kulay casting products. For example, out of 67 recorded bronze items originated from the Sarovsk cult place, only 16 can be considered successful. In varying degrees casting defects are inherent for Stepanovsk, Kulay, Murlinsk and other artifacts. Usually casting defects are caused by procedural violations, due to careless preparation of the alloys, non-compliance with temperature regulations in the process of casting and also due to the poor condition of molds. Kulay culture reached its fullest flower at the Sarovsk stage. The process of total reorganization of the material and technical base is coming to an end iron becomes the main industrial raw material for the production of leading implements and weapons. An increase in labor productivity, regulation of division of labor in a community leads to wealth disparity in its population. Castings become a part of clothing and harness. Castings with volume elements equipped with loops for attaching to any basis are becoming popular. The socio-economic system of the Kulay society acquires open nature. The exchanging and cultural ties with neighboring cultures are growing. Domestic metal production for internal requirements becomes secondary, ceases to be mass. Due to specialization of labor in metalworking and metallurgy the resulting product is realized not only within the family community, but also beyond.


To make proper risk assessments of sites with contaminated soil it's important to understand the biogeochemical processes determining transport and sequestration of the contaminants in soil. Soil organic matter (SOM) is the most important component in soil for adsorption of hydrophobic organic compounds (HOC) and the organic carbon normalized partitioning constant (KOC) is used to model partitioning of HOCs between the aqueous phase and SOM. The aqueous solubility of HOCs is low and association to dissolved organic matter (DOM) in soil solution is therefore important for the mobility of HOCs. Similarly, association to the solid phase of SOM, in this thesis denoted particulate organic matter (POM), controls the retention of HOCs in organic rich soils. Few data are reported on the partitioning of HOCs to DOM (KDOC) and to POM (KPOC) determined in the same equilibrium system. In short-term adsorption experiments with controlled equilibrium systems, adsorption to DOM and POM was best described by linear isotherms for chlorophenols (CPs) and nitrobenzene (NB), indicative of a hydrophobic partitioning mechanism. Adsorption of aniline was best described by the Langmuir isotherm, indicative of a specific interaction to functional groups of DOM and POM. Trinitrotoluene (TNT) adsorption data revealed specific interactions of degradation products to DOM and hydrophobic partitioning of TNT to POM. As a complement to the short-term adsorption experiments, soils with aged contaminants were investigated. Chlorophenols (CP), phenoxy phenols (PCPP), diphenyl ethers (PCDE), dibenzo-p-dioxins (PCDD) and dibenzofurans (PCDF) associated to DOM and POM and the free analyte in the aqueous phase were determined. In both the adsorption experiments and the soils with aged contaminants, POM showed a higher binding affinity towards HOCs than DOM, when normalized to organic carbon content. The partitioning towards POM, relative to DOM, increased with increasing hydrophobicity of the classes of compound studied in the order CP<PCDE<PCDF<PCDD. No major differences in carbon chemistry were revealed between DOM and POM (using 13C-NMR, XPS and elemental analysis), thus it is suggested that some other property is responsible for the difference in binding to POM and DOM. The physical size of hydrophobic structures could be such an important property.


An internal reinforcement structure herein disclosed composites, the use of such a suitable composite material, and related methods of manufacture. In one embodiment, a method for manufacturing a reinforcing structure comprises forming a precursor assembly and peeling the precursor, the precursor having a crystalline lattice structure comprising a plurality of layers. As a result, the distance between the plurality of adjacent layers of the crystal lattice is expanded. The method also includes the use of support material surface around the periphery of the respective lattice layers peeling precursor of at least a portion of the precursor coating peeled off.


Wood is produced in successive cylindrical layers during the radial secondary growth of a tree by a very thin layer of living cells that divide, called cambium, and located under the bark. Wood is composed of different kinds of cells, with a honeycomb-like cellular organisation, and each plays a particular role for the tree. From a mechanical point of view, fibres are the cells that compose the structure (skeleton) of the tree (Thibaut et al, 2001). Figure 1 shows the idealized multi-layered structure of a typical wood fibre (typically around 1 mm long and around 20 μm in diameter). Each wood cell wall layer plays a particular role in the mechanical behaviour of wood and the elastic properties of wood originate mainly in those of its secondary cell wall layers. Each layer, particularly in the secondary wall, can be seen as a unidirectional long fibre composite whose fibres are cristalline (at around 70%) cellulosic microfibrils (as long as the cell and with some nm in diameter) and the matrix is made up of amorphous polymers: hemicelluloses, lignin and extractives (Salmen, 2004). The microfibrils are inclined to the cell axis by the so-called microfibril angle (MFA).


Three dimensional (3D) HfO2-ZnO heteroarchitecture comprised of thin coating of HfO2 on self assembled 3D ZnO urchins with pointed apex has been synthesized using hydrothermal route followed by Pulsed Laser Deposition (PLD). The as-synthesized HfO2-ZnO heteroarchitecture was characterized using XRD, SEM, EDS, and (HR) TEM, in order to reveal its structural, morphological, and chemical properties. The HfO2-ZnO heteroarchitecture emitter exhibits superior field emission (FE) behaviour in contrast to the pristine ZnO urchins, demonstrated by delivery of high emission current density of ∼ 885 μA/cm2 at an applied field of ∼ 3.35 V/μm, against ∼383 μA/cm2 at an applied field of ∼ 4.32 V/μm for the pristine ZnO urchins emitter. Interestingly, the HfO2-ZnO heteroarchitecture emitter exhibits excellent emission current stability characterized with fewer fluctuations, owing to very good ion-bombardment resistance offered by the HfO2 coating. Furthermore, the heteroarchitecture thus obtained facilitates tailoring of the morphology with high aspect ratio and modulation of electronic properties as well, thereby enhancing the FE behaviour.Despite HfO2 being wide band gap and high-k material, the HfO2-ZnO heteroarchitecture exhibits potential as promising candidate for fabrication of high current density cold cathode


Zoe Stewart-Marshall is a Database Enrichment Librarian at Cornell University, Ithaca, NY. Mason Hall is from Florida State University, Tallahassee, FL.


This article considers the application of the general exceptions of the WTO GATT and GATS to investment arbitration under international investment treaties. It suggests that the designated categories and balancing contemplated by the WTO exceptions, along with its sophisticated and established jurisprudence may offer useful guidance to arbitrators seeking to evaluate public interest exceptions implemented by host states. Improvements to the trade-inspired general exceptions for use in the investment context in order to enhance this exercise are also proposed. Taken together these initiatives may help promote the legitimacy of investment arbitration, a procedure which continues to face criticism for its failure to consider non-economic elements raised during disputes.


Article Info Abstract: In this study, it was aimed to determine the medium where Lactobacillus fermentum microorganisms with probiotic properties grow most efficiently by using Response Surface Method (RSM). Studies have been conducted on a 500 ml erlenmeyer scale, the medium optimization of the Lactobacillus fermentum strain was carried out according to the Central Composite Design (CCD) included in RSM. The effects of glucose, yeast extract, inorganic salts, and Tween 80 were investigated on the growth rate of the L. fermentum NBC-08 strain. Samples were taken at regular intervals from the erlenmeyer flask and the number of viable cells was measured by planting them in petri agar medium. In the study, the number of viable cells log10 (cfu/ml) was chosen as the response variable. As a result of the study, it was concluded that glucose and yeast extract are absolutely essential components in the medium. The optimum medium composition was found as 96.06 g/L glucose, 40.76 g L-1 yeast extract, 19.43 g L-1 inorganic salts, and 11.01 ml/L Tween 80. The production of the maximum L. fermentum strain was determined as 10.75 log10 (cfu ml-1). It is predicted that this study will make positive contributions to the fermentation conditions and medium optimization studies for production of lactic acid bacteria. Received: 10.09.2021 Accepted: 10.02.2022 Online Published: 15.03.2022 DOI: 10.29133/yyutbd.993781


Abstract Operad theory, developed by J. P. May in algebraic topology in 1970s, found its usage in many other branches of mathematics, such as algebra and algebraic geometry. It generalizes those original algebraic types which admit only some binary operations. Moreover, it gives a natural filtration to each free algebra over an operad, which makes it easier to calculate some invariants of algebras over it. In this paper we try to summarize the basic theory about operads and give some of its first properties. It seems that the most general definition of operad is operads in an arbitrary symmetric monoidal category. We first define the action of a group G on an object in an arbitrary category (not necessarily monoidal) S. Definition 1. Let G be a group and x ∈ S an object. A left action of G on x is a group homomorphism G → AutS(x, x), where AutS(x, x) is the group of units in the monoid homS(x, x) under composition. A right action of G on x is a function G → AutS(x, x) which becomes a group homomorphism when composed with the inverse map G → G. It is not hard to see that we can generalize to define a left action of a monoid G in Set on an object x to be a monoid morphism G → hom(x, x), where the hom-set is a monoid under composition of morphisms—-the image of G will certainly fall into its subgroup of units when G itself is a group. Now we turn to the definition of operad. Definition 2. An operad C in a symmetric monoidal category (S,⊗, κ) is a collection C(j) of objects in S indexed by j ∈ N together with a right action by the permutation group Σj on C(j) for any j, a map η : κ→ C(1) and maps


a subject so full of charms. It is not mere practical usefulness that entitles this or that production to our notice ; the graceful and the beautiful have place in nature, prominent and unquestioned, aud if we but listen at moment, we shall hear the pulsations of the inner heart that respond to them, beat for beat. And we shall do well to heed it, and not be anilglly with ourselves if, stealino' a brief space now and then from sterner employment, wve give ourselves to the contemnation and enjoyment of that generous and spiritual delight wherewith a bouMntiful Creator plainly designs to refresh the weary and jadcld spirit. We cannot overlook mere beauty here, for the flowers tell us


The organization of long-distance passenger flow plays a vital role in the process of line planning. It can improve the efficiency, capacity utilization, and service quality of railway transportation. The organization of long-distance passenger flow is a hot but hard topic, as it involves so many factors and the relationship among them is very complicated. This paper focuses on the organization mode choice of long-distance passengers under different conditions. First, the basic organization schemes of long-distance passengers are discussed. Then, the influence factors of operating long-distance passenger trains are analyzed. In order to evaluate different passenger organization schemes, a cost function is established. Next, a numerical example is presented and examined. The result of the numerical example shows that the proposed method can offer support for decision-making of railway operators. Finally, as passenger transferring is unavoidable sometimes, methods for improving passenger transferring efficiency are discussed.


Various sensors in high-speed train positioning systems are usually installed outside or inside of a train in accordance with their intended purpose and specifications. This causes structural errors of the systems due to the differences of installed positions for train positioning sensors. Since these errors affect the performance of the whole systems, it is required to measure relative positions and/or be compensated appropriately. This paper presents a method of relative position measurement of installed sensors in the train positioning systems.


Sewage sludge improves agricultural soil and plant growth, but there are risks associated with its use, including high heavy metal content. In this study, experiments were carried out to investigate the role of endophytic Talaromyces pinophilus MW695526 on the growth of Triticum aestivum cultivated in soil amended with sewage sludge and its phytoremediation ability. T. pinophilus could produce gibberellic acid (GA) and stimulate T. aestivum to accumulate GA. The results showed that inoculation with T. pinophilus boosted plant growth criteria, photosynthetic pigments, osmolytes (soluble proteins, soluble sugars and total amino acids), enzymatic antioxidants (catalase, superoxide dismutase and peroxidase), K, Ca and Mg. On the other hand, it reduced Na, Na/K ratio, Cd, Ni, Cu and Zn in the growth media as well as in the shoot and root of T. aestivum. The results suggest that endophytic T. pinophilus can work as a barrier to reduce the absorption of heavy metals in T. aestivum cultivated in soil amended with sewage sludge.


We have studied the interactions between magnetically driven, DNA-linked anisotropic and isotropic colloidal rotors interacting via induced magnetic dipolar and multipolar forces. We show that a balance between magnetic dipole-dipole and dipole-hexapole interactions near the magic angle allows discrimination between spherical and anisotropic magnetic colloidal rotors.


The [N-(p-tolylsulfonyl)imino] phenyliodinane (PhI=NTs) was found to be an efficient reagent for imidation of variety of aldehydes using [RuCl2(PPh3)3] as catalyst in the presence of triphenylphosphine.


The purpose of this paper and the accompanying tables is to facilitate the calculation of constrained optimum order quantities and reorder points for an inventory control system where the criterion of optimality is the minimization of expected inventory holding, ordering, and time-weighted backorder costs. The tables provided in the paper allow the identification of the optimal solution when order quantities and/or reorder points are restricted to a set of values which do not include the unconstrained optimal solution.


Of orange and yellow eyelids Polat presented the case of a 53-year-old woman with orange rings in the periorbital area. These rings were interpreted as an accumulation of carotene in xanthelasma lesions. However, we would like to point out that cases with a very similar bilateral orange discoloration of the upper eyelids have already been reported and referred to as orange palpebral spots (OPS). In a series of 11 cases, only five had high levels of b-cryptoxanthin. The authors considered these high levels due to the abundant consumption of citrus fruits during winter. Moreover, only one of 11 patients had an increased level of serum carotenoid. The histology of nine of 10 patients revealed high-situated adipocytes in the reticular dermis and autofluorescent microgranular deposits possibly reflecting lipofuscin in one patient. However, no xanthomization was found. Hence the authors hypothesized that OPS is an under-recognized pattern distinct from xanthelasma or carotenoderma. As in our case (Fig. 1), most reported cases are middle-aged Caucasian women without a history for external factors possibly causing the discoloration, dyslipidemia, or carotenoderma. A differential diagnosis of OPS is a yellowish palpebral discoloration owing to fluorescein used in ophthalmology (Fig. 2). As some fluorescein solutions might be sticky and poorly washable, the discoloration might last some days. Depending on the distribution of the fluorescein, the lower eyelids are more often involved than in OPS. We propose to use the term fluorescein palpebral spots (FPS) to describe this discoloration. Necrobiotic xanthogranuloma is another differential diagnosis of an orange or yellowish palpebral discoloration (Fig. 3). It is mostly seen in patients with monoclonal gammopathy. In this condition, the discoloration is on plaques involving not only the eyelids but also the periorbital area and hence might be mistaken for xanthelasma. In systemic amyloidosis, the periorbital papules and plaques might be yellow–brown, but usually also present purpura due to the fragility of skin vessels. The heliotrope rash seen in dermatomyositis might have only a subtle yellowish appearance but is more often lilac and accompanied by eyelid swelling. A nevus sebaceus might also occur in the periorbital area (Fig. 4) and is characterized by a unilateral papular yellowish plaque.


the actual highest position, was first attained by Ankhnesneferibre, the last God's Wife of Amun. Although the author presents several interesting interpretations of the various rites and rituals conducted by the God's Wives, the second chapter becomes too protracted and descriptive. To facilitate the reader, Ayad could have included photos or drawings of all the reliefs that she describes. The most interesting part of the book is the third and final chapter, 'Avenues to legitimacy'. Ayad opens with an analysis of the gradual appropriation of priestly duties by the five God's Wives – starting with the consecration of offerings to the gods by Shepenwepet I and ending with Ankhnesneferibre's appointment as High Priest(ess) of Amun. The assumption of priesthood was only one of the strategies utilized by the God's Wives to legitimate their position. The author proceeds to a discussion of the individual God's Wives' avenues to legitimacy through propagandistic iconography on the walls of the chapels that they built. In this chapter, Ayad's extensive descriptions of the reliefs in the second chapter of the book are finally placed in a broader political and historical context. The interesting views of the author of God's Wife, God's Servant are written using a clear and informative language. Unfortunately though, the publication suffers from some spelling mistakes and a few repetitions that should have been avoided. It is positive for the publication that most of the illustrations are photos taken by the author and not reproductions from other books. Sadly, some of them are taken from a strange angle (e.g. fig. 2.9), contain shadows (e.g. fig. 2.12) or have odd frames (e.g. fig. 2.11). This might, however, be due to the conditions at the sites during the visits by the author. In conclusion, Ayad has made a significant contribution to the status of women in the history of Ancient Egypt with her book about the God's Wives. The first and the third chapters of the book are enlightening for the general reader, while the second chapter has most relevance for specialists particularly interested in the religious roles of the God's Wife.


Miniaturization scaling of technology node is advancing in recent years, we are almost facing to the age of mass production for ultra-fine devices with the design rule of one-digit nanometers. Along with the scaling of technology node, distance of neighboring wires or contact plugs is inevitably reduced, and so, occurrences of short circuit defect are increasing. So far, various methods had been applied for investigating short-circuit failures. The failure analysis by SEM based electron beam absorbed current (EBAC) technique recently becomes main-stream technique among them because of its spatial resolution to determine the failure position. The DI EBAC that is the EBAC observation acquired by applying some voltage to the failure short circuit and forcing to run bias current through it was known to be effective to fix the malfunction position of failure short circuit. However, it is necessary for making the evaluation condition of the DI EBAC to have the best results. Especially, malfunction area localization for low resistive short failure is difficult by conventional technique, thus, the focus point of measurement condition is to find out DI EBAC short failure localization ability for low resistive short failure mode. In this study, several samples and measuring parameters were evaluated to find the most effective conditions in the DI EBAC. We confirmed that suitable measurement condition was possible to obtain hotspot signals in actual short failure analyses as low resistive shorted failure sample.


Rice is the very important cereal crop of Odisha. But unfortunately productivity of rice crop in Odisha is below the national average. Adverse climatic condition is the main cause for lower productivity. Further global climate change possesses a high threat to agriculture. Mainly change in weather pattern affects the cropping area and productivity. Hence, there is a need to study about adverse climatic factors which impact Rice yield under projected climate change. A field experiment rice was conducted during kharif 2015 in the Agrometerology field experimental area of OUAT, Bhubaneswar to validate simulated duration to developmental stages and yield with observed experimental data using DSSAT Ceres-rice model software. Khandagiri and Lalat were experimental cultivars. Climate change scenarios included weather parameters i.e. temperature, rainfall and solar radiation at Bhubaneswar following RCP 2.6, 4.5, 6.0 and 8.5 scenarios (VanVuuren et al., 2011). Future rice yield projections were made for 2020,2050 and 2080. Earliest and latest transplanting produced less tillers m -2 whereas mid-season transplanting dates from August 1 to 15 produced more tillers m -2 .Swarna and Lalat produce more tillers than Khandagiri. Similarly LAI was recorded high in mid-season transplanting and low in earliest and latest transplanting. Dry matter production is also more in mid-season transplanting and less in earliest and latest transplanting dates. Swarna produce the highest dry matter. Grain yield production is highest in Swarna as it produced highest panicles m -2 than other varieties. Grain yield, number of panicles m -2 and HI is more in August 1 transplanting than other transplanting dates. Number of grains per panicle, Number of filled grains per panicle and 1000 grain weight did not vary with the transplanting date. Swarna produced the highest number of grains and filled grains per panicle whereas Lalat has the highest 1000 grain weight. Validation of simulated values obtained from CERES-Rice model of cv. Khandagiri and Lalat with observed data showed good agreement between them. The high d-index value showed high accuracy in the simulated prediction. The model has also higher accuracy in predicting grain yield, straw yield and days taken to growth stages as inferred by the d-index values. In cv. Khandagiri and Lalat Seasonal temperature increasing by 1-2 0 C combining with increase in rainfall and solar radiation as per RCP scenarios causes increase in yield of kharif rice however, grain yield decreased with increase in temperature of more than 2 0 C along with solar radiation more than 3.8 MJ/day. In 2020, there is an increase in yield but in 2050, there is almost no change in yield except for latest transplanting date. However, in 2080 yield increases under early and late transplanting dates but declines in midseason transplanting. RCP 8.5 scenario results in declining yield in all transplanting dates in 2080.


Abstract The general equation for the equilibrium shape of an ideally thin, flexible, inflated, undeflected cord tire is derived from the equilibrium conditions for an individual cord. Various special cases are discussed and equations are derived for the cord tension, bead tension, and shearing stress between plies.


This interactive digital installation, in which human-machine interaction is aligned to 'Agency', 'Situation' and 'Embodiment'. The control of the virtual world via body-joint movement, and tracked position, velocity, gestures are directly linked to archi-tectonic forms, distortion of space and perspective. It challenges unconscious associations with familiar, embodied habitual experiences of Cartesian-space. The expected reading and interpretation of body-movement, is translated into a reflexive aesthetic language that causes the particpant to reanalyze there position, gesture in space.


Ideal piezoelectric material should possess the following four properties: (1) high piezoelectric coupling, (2) low acoustic loss (high Q), (3) temperature compensation and (4) capable to produce large crystals at low cost. To find any crystal which can meet all these requirements is a the challenge. Recent work from Russia, Japan and France shows that LGS and some of its isomorphs (such as LGN and LGT) can satisfy all these requirements and thus stir a lot of interest. Since these crystals can be grown directly from the melt by the conventional Czochralski pulling method, the availability of low cost large size crystals is a possibility. Melt composition control is the most critical parameter to adjust. Moreover, the melt has small selective evaporation and the composition does change with time. It introduces inclusions and limits the crystal yield. Crystal cracking is a more serious problem which, we believe, is primarily due to twinning. Based on the P321 space group symmetry, the crystal is expected to have electrical twins. Using chemical etching, twinning domains are observed. To grow single domain crystal, it needs very tight control of the growth process free from any thermal or mechanical perturbation. Using our newly developed adaptive control system and full power UPS back up, we are able to grow high quality single domain LGS crystals and its isomorphs with material yield better than 80%. Typical crystal size is 50 mm in diameter and 120 mm in length using a small 75 mm diameter crucible. The crystal produced is essentially transparent for all three compositions. This is in contrast to the typical dark brown color crystals available in the market. The growth of large diameter LGS crystals would depend entirely on the ability to minimize the thermal mechanical stress and thus avoid the formation of twinning.


The integrated theory proposed by Elliott et al. (1979), combining strain, social control, and social learning theories, has been tested and supported for individuals who were adolescents in the mid-1970s. The present research tests this theory in parallel models for a first generation consisting of a national sample of adolescents in 1976–1978, and a second generation, the adolescent children of the first generation, in 2002–2004. There is evidence that relationships among the variables in the model have changed over time, but the core of the integrated theory continues to be supported for the second generation.


Extrinsic motivation has a very important role decisive and encouraging students to learn with full attention and concentration in a lesson, so that the attainment of the objectives expected by the students that good learning performance with increased learning achievement. This study aims to determine the relationship between the extrinsic motivation of students with student achievement class V SD cluster I Tualang district Perawang. This research method was correlational. The sampling technique using one of the techniques in simple random sampling. Methods of data collection using questionnaires and engineering documentation of the average value of first semester report card of the school year 2015/2016. The analysis technique used is the technique of analysis Product Moment. Test requirements analysis in the form of normality test and linearity test. Engineering analysis and test requirements analysis using SPSS 20. The results showed that there is a positive relationship between extrinsic motivation and academic achievement of students in class V SD cluster I Tualang district Perawang, obtained rxy of 0.511 with a degree of correlation being as well as extrinsic motivation to contribute to the achievement learning by 26.1%. The results of hypothesis testing using correlation, there is a significant relationship between extrinsic motivation and academic achievement of students in class V SD cluster I Tualang district Perawang, obtained rhitung (5,885)> r table (1.984), then Ho is rejected and means Ha acceptable means there significant relationship between extrinsic motivation and academic achievement grade elementary school students throughout cluster I the District Tualang Perawang.


The marine manatee ( Trichechus manatus ) is one of the most endangered marine mammals in Brazil, and is currently classified as vulnerable to extinction. The main risks to the conservation of the species are from natural causes, such as the slow birth rate, human actions and infectious diseases. Among the main objectives of the National Centre for Research and Conservation of Aquatic Mammals, the Chico Mendes Institute for Biodiversity Conservation (CMA/ICMBio) is to promote scientific research and management actions for the conservation and recovery of endangered species of marine mammals, and develop and promote rehabilitation in captivity and release natural environment of the marine manatee. The passage of these individuals for captive is of utmost importance for the conservation of the species. The rehabilitation of captive cubs marine manatees and allow recovery and can return the animal to the natural environment, enables a greater knowledge of the species, referring to biological, behavioral and clinical. Studies on the parasitism of manatee in Brazil are few elucidated, more research related to the topic, it is necessary to better understand the disease and health aspects of the species. This work aims to realize the isolation of the parasite in urine samples of marine manatee kept in the rehabilitation process. All animals included in the study are from the rehabilitation center for wild animals CRAS/CMA/ICMbio , located in Itamaraca, State of Pernambuco. This deal is the first description of parasites in urine manatee in Brazil and can support management actions to be taken to ensure the health of animals in rehabilitation.


We review the requirements of a power amplifier used in portable communication applications. The talk time or battery life of a portable unit is directly related to the transmitter RF conversion efficiency. The introduction of GaAs MESFETs, HFETs, and HBTs into portable communications equipment increased the performance level of RF power functions. The effect is a significant improvement in DC to RF conversion efficiency over the previous bipolar RF power amplifiers. Circuit applications and trade-off of MESFETs, HFETs and HBTs for portable communication system is also discussed.<<ETX>>


ABSTRACT: This theoretical article, elaborated from an integrative literature review process, makes an unswerving defense of the concept of inclusion, taken as a cornerstone, the production of a democratic and liberating educational practice. It challenges head-on the temporarily suspended Presidential Decree no. 10.502 of September 30, 2020, which establishes the new National Policy for Special Education, believing that it is based on a fragile idea of inclusion as restricted to the presence of students with disabilities in regular classrooms, without considering the deep and unpostponable transformations that the supposedly inclusive denotes to enable everyone to learn satisfactorily, with a view to equal participation in society. The theoretical scope which guides the critical lines established herein refers to the literature conventionally called the social model of disability, which has the understanding of disability under the prism of historical production as its central idea and from the perspective that the person with a disability is not reduced to their deficit. The texts employed in this article take this assumption as a driving force when visualizing in the experience of disability endless educational possibilities which allow enriching and complexifying human development and the ways of intervention concerning the environment around us from original platforms with a positive impact in the whole collectivity. It links such relationships in school environments to curricular adjustments, didactic reconfigurations, construction of accessible spaces, and the transformation of the very meaning by which disability is conceived in the school terrain.


Abstract Background Although largely preventable, tooth decay (dental caries) is among the most common health conditions worldwide and contributes to substantial dental treatment expenditures. While Fluoride Toothpaste (FT) is considered an essential strategy for oral health prevention, its market price has been shown to vary substantially across various settings. Against this background, the present study aimed to develop a decision analytical model to evaluate the cost-effectiveness of FT in various settings. Methods Leaning on WHO CHOICE methodology, evidence scoping and an expert consensus were facilitated to extract model input parameters which were then fed into cost-effectiveness-analyses (CEA) for FT. The cost-effectiveness of the interventions was expressed as cost per Disability-Adjusted Life Year (DALY) averted. Results The CEA identified a high likelihood for FT to be a cost-efficient treatment strategy in settings with comparably low market prices for FT. FT was less likely to be a cost-efficient treatment strategy in settings with comparably high market prices for FT. Conclusions The developed decision analytical model is suitable to inform policymakers about the extent to which FT represents good value-for-money under different market prices. Key messages • Fluoride toothpaste can provide high value for money as an oral health preventive strategy. • Policymakers need to ensure the affordability of fluoride toothpaste in order to harvest relevant efficiency gains.


Advances in MEMS technology have resulted in relatively low cost gyroscopes and accelerometers and, correspondingly, inexpensive inertial measurement systems. This has opened up the field of applications for inertial measurement units (IMUs) and they are currently being proposed for use in a wide variety of possible applications, with environmental conditions ranging from mild to harsh. Of particular interest in this study are MEMS gyroscopes, which are based upon vibratory, rather than rotational, designs and are especially susceptible to the effects of acoustic noise, as compared to conventional gyroscopes. This is particularly true for certain applications. For example, in some aerospace environments, noise levels can be greater than 120 dB and extend over a frequency range greater than 20 kHz. Output signals can be overwhelmed by such effects, becoming extremely contaminated and noisy and, can even be completely saturated. So, it is important to develop an understanding of the influence of high levels of noise on MEMS gyroscope performance and to develop methodologies to mitigate such effects. In the present investigation, a series of experimental studies were conducted for a variety of MEMS gyroscope designs. Each unit was exposed to a range of acoustic noise amplitudes and frequencies. The output signals were recorded and analyzed. The results are presented and discussed in detail. Strategies for mitigating such effects were identified and tested. Those results are also discussed in detailed.Copyright © 2007 by ASME


STUDY DESIGN
A multicenter, retrospective study of long-term surgical and nonsurgical patient outcomes, after lumbar discography.

OBJECTIVES
To investigate the efficacy and surgical outcome predictive value of categorizing positive discography findings, using a pressure x pain provocation categorization system.

BACKGROUND
With the use of pressure-controlled manometric discography, improved and more specific diagnostic categorization is possible. The literature suggests that more specific categorization of positive discographic findings may predict surgical and nonsurgical outcomes. Studies have shown that intertransverse fusions may not fully protect the disc from anterior loading. Consequently, in patients who have low-pressure-sensitive discs, surgery that includes interbody fusion should provide a more favorable long-term outcome than intertransverse fusion only.

METHODS
Long-term outcome was ascertained in 96 patients who had lumbar discography and subsequently underwent interbody fusion alone, combined fusion, intertransverse fusion or no surgery. Patients were retrospectively placed into specific diagnostic categories, according to a four-point scale. Progressively restrictive subgroups, beginning with the entire sample and ending with the most sensitive group (chemically sensitive), were examined for long-term surgical outcome differentiation.

RESULTS
There were no significant differences in long-term surgical outcome across the entire sample. However, significant outcome differences existed across the subgroup of patients with chemically sensitive discs. In this group, patients undergoing interbody/combined fusion had a significantly better outcome than patients who had intertransverse fusion. Nonsurgical patients had the worst outcome overall.

CONCLUSIONS
Patients with highly (chemically) sensitive discs appear to achieve significantly better long-term outcomes with interbody/combined fusion than with intertransverse fusion. Patients without disc surgery have the least favorable outcome. Precise prospective categorization of positive discographic diagnoses may predict outcomes from treatment, surgical or otherwise, thereby greatly facilitating therapeutic decision-making.


OFFICIAL ROAD ACCIDENT STATISTICS IN FEDERAL GERMANY ONLY TAKE INTO ACCOUNT THOSE ACCIDENTS AFFECTING PROPERTY DAMAGE IN EXCESS OF 1000 DM FOR ONE PARTY. AT PRESENT THE ACTUAL VALUES OF PROPERTY DAMAGE ARE NOT RECORDED. THIS SITUATION LIMITS THE ABILITY OF OFFICIAL STATISTICS TO PROVIDE INFORMATION FOR MAKING COMPARISONS OF VARIATIONS WITH TIME, SINCE WITH THE AVERAGE DAMAGE VALUES CHANGING CONTINUOUSLY WITH TIME, (A RECORDING LIMIT OF 1000 DM IN 1964 CORRESPONDS TO ABOUT 3150 DM IN 1975), THE NUMBER OF ACCIDENTS RECORDED CHANGES AND WITH THIS STRUCTURAL SHIFTS IN THE DATA SUPPLY BECOME EVIDENT. IT IS NECESSARY, AT LEAST FOR THE PURPOSES OF COMPARISON, THAT EVALUATIONS OF ACCIDENT STATISTICS ARE CARRIED OUT WHICH ARE BASED ON A RECORDING LIMIT WHICH CORRESPONDS TO COST DEVELOPMENTS WITH TIME. BUT IT IS NECESSARY TO HAVE A RECORD OF ALL PROPERTY DAMAGE ACCIDENTS WITH THE DAMAGE-VALUE FOR EACH, IN ORDER TO PROVIDE A DATA BASIS TO COVER SEVERAL EVALUATION PURPOSES. AS AN EXAMPLE THE IDENTIFICATION AND EVALUATION OF LOCAL ACCIDENT BLACK SPOTS SHOWS THAT ASSESSMENTS TAKING INTO ACCOUNT INFORMATION ABOUT THE PROPERTY DAMAGE OF ALL ACCIDENTS LEADS TO BETTER RESULTS THAN WHEN CONSIDERING ONLY THOSE ACCIDENTS IN WHICH PERSONAL INJURY HAS OCCURRED.


Background. Indonesia is the fourth most populated country in the world with a high rate of population growth and maternal mortality. To resolve this matter, Indonesian goverment implement the "Keluarga Berencana" program. According to BKKBN in 2007, 55.5% women are using injection contraceptive and the majority has an elevated BMI. Elevated BMI is associated with the increased number of adipose cell in the body thus influencing the leptin level. objective. To determine the correlation between Body Mass Index (BMI) and leptin level on Depo Medroxy Progesterone Acetate hormonal contraceptive users. methods. This research method applied in this study is cross sectional. The study is conducted at the Department of Obstetrics and Gynecology, Faculty of Medicine, University of Sumatera Utara, H. Adam Malik General Hospital and Puskesmas Helvetia on August 2017 by consecutive sampling. After participants agree with the informed consent, BMI was measured and 3 cc of blood was drawn from median cubiti vein at 07.00-08.00 during fasting. Data were analyzed using Spearman correlation test with p value < 0,05. results. Out of 95 participants, 42 participants (44,2%) have age interval between 30-39 years old and 79 participants (83,2%) have leptin level > 5. Most of DMPA hormonal contraceptive users were overweight at month 0 and 12, in which 42 participants (44,2%) and 33 participants (34,7%) at month 24, 46 participants (48,4%) have obesity grade I. Conclusion. There is a strong and significant correlation between body mass index and leptin level on DMPA hormonal contraceptive users (r= 0.70, p= 0.0001).


Pedagogy is a required subject in advanced teaching colleges, but at present it didn't develop well. In this paper ,I have done some primary thought and research into the necessity of teacher's parts in teaching as well as the teaching process and solutions to the standards of grading.


Brown, Marquet, and Taper (BMT hereafter) have endeavored to derive the distribution of animal sizes from bioenergetic onsiderations (Brown et al. 1993). After some remarks about the field itself, I shall discuss my reservations concerning BMT's measure of fitness, which assumes that it is optimal to maximize the production rate; their use of a two-step reaction model of resource conversion, neglecting animal behavior; and the legitimacy of BMT's predictions of size distribution. An energetic measure of fitness should be related to Darwinian fitness, defined as lifetime reproductive success. In a broad range of ecological situations, this success can be expressed as lifetime offspring production (Houston and McNamara 1992; Kawecki and Stearns 1993; Kozlowski 1993). To convert offspring production to energy units, it is enough to assume constant energy content of offspring. Then the parameters leading to maximization of lifetime energy allocation to reproduction can be found. This problem has been studied by many authors through models of optimal allocation of resources to growth and reproduction (see Kozlowski 1992; Roff 1992; Stearns 1992; Perrin and Sibly 1993 for review). At first glance, it seems reasonable that the body size that maximizes reproductive power (production rate during reproduction) is optimal. Unfortunately, this would be true only for immortal organisms. In other cases, this assumption is fallacious (see Perrin and Sibly 1993 for review). It takes time to grow to a given size, and death can occur during both growth, when the reproductive machinery is being built, and mature life, when the reproductive machinery is used. A given calorie should be allocated to growth as long as the increase of body size resulting from this calorie elevates the expected energy content of future offspring by more than 1 cal. Otherwise, it is better to allocate this calorie directly to reproduction. Expected offspring production (in energy units) is the product of the production rate, or reproductive power in BMT's terminology, ahd the expected period of reproductive allocation. Under size-independent mortality, it is optimal to grow, as long as the derivative of the production rate with respect to body size times life expectancy is greater than one. If the dependence of the production rate on body size is humped, the optimal size is always located to the left of peak production. This is because the gain in the production rate lessens as the size yielding maximum production is approached; for some size, the product of this gain and life expectancy is smaller than one, unless the animals live forever.


ABSTRACT It is important to investigate gas-water multiphase flow in methane hydrate-bearing sediment. In this work, we measured relative permeability of gas and water in artificial methane hydrate bearing sediment by the unsteady state method, and determined the effects of hydrate saturation on relative permeability curves. The results show that the relative permeability shifted left with increasing hydrate saturation.


Americans are lactose intolerant (1). Lactose intolerance is the inability to digest significant amounts of lactose, the predominant sugar in milk. The intolerance, which originates from a diminished production of lactase by the cells of the small intestine, may manifest itself in the form of nausea, cramps, bloating, gas, and diarrhea. These symptoms are a consequence of undigested lactose, which is fermented in the colon by bacteria to metabolic gases, lactic acid, and short-chain fatty acids (1). No treatment exists to improve the body's ability to produce lactase, except through modification of one's diet. The approach is to consume foods and drinks that naturally have little or no lactose or that are enzymatically processed to reduce lactose levels (2). Hence, a better understanding of the lactase enzyme is essential to harnessing its power for health and commercial reasons. The study of enzymes (e.g., exoand endoglycosidases) which utilize carbohydrate substrates has been hindered by the poor optical detection properties of their substrates and/or products. Kinetic analysis has often relied upon derivatized substrates or the monitoring of side products (e.g., peroxide released from glucose oxidase reaction). These approaches can give incongruent results (different rates/kinetics for a chemically modified vs. unmodified substrate) and can be less specific (side products may be from multiple sources), respectively. Many glycosidase reactions do not even produce an easily measurable product. In addition, substrate modification and indirect methods may not be applicable to on-line process monitoring of real systems (e.g., enzymatic hydrolysis of lactose in milk). Microdialysis has been developed and used mostly for in vivo applications, particularly in the neurosciences (3-6) and pharmacokinetic studies (5,7,8). Other than characterization studies (e.g., calibrations, use of alternative membranes) of in vivo probes external to the biosystem of study, only a limited number of in vitro applications (all using in vivo design probes) have been published (9-15). These studies have focused on microdialysis as a one-step clean up approach (typically based on size), an alternate technique to equilibrium dialysis for drug bindMonitoring In Vitro Enzymatic Digestion of Lactose in Milk Using Microdialysis with Pulsed Amperometric Detection


Tennis is a sport characterised by being played on different surfaces: hard court, grass and clay. These surfaces influence the style of play and tennis specific movements. Specifically on clay, most of the common movements performed by players (e.g. accelerating, side stepping and braking), are performed with some level of controlled sliding. In order to reduce the player's injury risk, and assess the shoe-surface requirements on clay surfaces, there is a need for a scientific understanding of the player's kinematics and tribological mechanisms occurring at the shoe-surface interface. The purpose of this study was to identify the kinematics of the shoe during the sliding phase, and to assess the friction that is present. Baseline areas of both ends of a clay court were prepared with two different mixes of clay, varying the particle size. Eight experienced clay players participated in this study which took place during the Conde de Godó tennis tournament in Barcelona, Spain. 3D kinematic data data was collected using two synchronised high speed video cameras, and after the tests, perception questionnaires were applied to the players. Additionally, three different mechanical devices were utilised to measure the friction of the two clay surfaces. Displacement and velocity data of the shoe in contact with the surface were correlated with the friction measurements from both clay surfaces. Results indicated that significant differences occurred between the two clay surfaces for some shoe kinematic data, and mechanical friction. However, the perception scores suggest the opposite behaviour stated by the mechanical test and shoe-kinematic data. The present study has provided evidence that shoe kinematics and friction of the shoe-surface interaction are affected by the surface conditions, specifically particle size. © 2014 The Authors. Published by Elsevier Ltd. Selection and peer-review under responsibility of the Centre for Sports Engineering Research, Sheffield Hallam University.


Spin correlation asymmetries of large angle elastic NN scattering are ideal for the study of the nature of the hard scattered partons. The scheme for two colored quarks to scatter by the exchange of a vector gluon is inconsistent with data, but the data rather agree with vector‐type scattering of two spin‐1/2 colorless fermions of small masses. The significance of extending the spin correlation measurements is also emphasized.


The problem discussed in this paper is to separate two (or more )input signals from observed signals which are generated by passing input signals through different unknown multi-input multi-output linear systems. It is proved that the input signals can be separated when they are independent identitically distributed (i.i.d) signals . A new algorithm for multi-input multi-output blind deconvolution via maximum entropy is presented which needs no information about the input signals and mixing filters.


Purpose – The purpose of this paper is to report research conducted in the UK's East Midlands region which explores optimising practice for low carbon building through an architectural award system.Design/methodology/approach – To explore the complexity of the contexts, philosophies and demonstrations involved in best practice for low carbon buildings, a mixed research approach was adopted through an online survey and interviews with 13 experts.Findings – The research provides practical means to evaluate low carbon buildings and suggests an approach where aesthetic design and technical compliance are given similar weightings. It also presents the opinions of construction professional practitioners and academics on best practice for low carbon buildings.Research limitations/implications – The research focuses on investigating the judging criteria and opinions of construction professionals who have, in the past, strongly identified with sustainable building design practice.Practical implications – As this r...


Abstract 427 Rituximab is effective as single agent therapy in the treatment of follicular lymphoma (FL), and when combined with chemotherapy has extended remissions and survival. Epratuzumab (Immunomedics), a humanized anti-CD22 monoclonal antibody, also has single agent activity in FL, and in combination with rituximab led to durable complete responses in the treatment of patients (pts) with relapsed and refractory indolent NHL. To evaluate the hypothesis that combining a second biological agent with rituximab might improve efficacy with good tolerability, the CALGB treated 60 previously untreated pts with epratuzumab and rituximab in a multicenter phase II trial and we report here the preliminary response and toxicity findings. Rituximab was administered at 375 mg/m2 iv weekly for four weeks, then every 8 weeks for four additional doses for a total of 8 doses over 9 months. Epratuzumab, was given at 360 mg/m2 two days before the first rituximab dose to assess toxicity. From week 2 on, epratuzumab was given before the rituximab on the same day for a total of 8 doses over 9 months. Fifty-seven evaluable pts were enrolled between May 2008 and September 2009. FLIPI scores at study entry were 13 (22%) low; 28 (47.5%) intermediate; and 18 (30.5%) high. Fifty-three pts completed all therapy through month 9. One pt was taken off therapy due to progression after month 5. One pt died during induction from line sepsis. Two pts were taken off study due to adverse events, 1 during induction (grade 4 thrombosis and MI), 1 following month 5 (dyspnea, hypoxia and pulmonary NOS). All other toxicities were grade 3 or lower, including fatigue (grade 3 3%, grade 2 17%), nodal pain (grade 3 5%, grade 2 8%), and cytokine release and pruritis (grade 2, 5% each). To date, there have been 19 CRs (33.3%), 29 PRs (50.9%)(ORR 84.2%); 9 (15.8%) had stable disease. All 19 CR patients completed all treatment. The mean time to CR was 9 months. Two patients progressed after a period of stable disease, and 25 of the 29 patients who achieved PR remain in response. All 19 CRs also remain in remission at this point with a median follow-up of 0.82 years (range 0.52 to 2.0). FLIPI score was not predictive of response. The CR rate in low risk pts was 31%, 44% in intermediate risk and 18% in high risk pts. There was a trend toward higher CR rate among patients with FcgR2A His (n=10, CR 60%) and to a lower CR rate among those with FcgR2A Arg (n=14, CR 14.3%). Correlations with PET scan at week 3, with tissue biomarkers and to statin use are being analyzed. Rituximab and epratuzumab is an effective and very well tolerated regimen with an ORR of 84% in previously untreated patients with follicular lymphoma. Disclosures: Off Label Use: Use of Epratuzumab, a humanized antiCD22 monoclonal antibody in treatment of follicular lymphoma. Leonard: BiogenIDEC: Consultancy; Genentech: Consultancy; Immunomedics: Consultancy. Jones: Glaxo Smith-Kline: Consultancy; Abbott: Research Funding. Cheson: Genentech: Consultancy.


Eight allergic reactions to IV iron dextran administration were recorded among 90 hemodialysis outpatients (8.8%) from April 1996 through April 1997. An action plan was instituted to determine the cause of this rate of allergic reactions and to protect our patients from further reactions. The plan included changing the iron dextran complex from ferric oxyhydroxide (Dexferrum®, American Regent Laboratories) to ferric hydroxide (INReD®, Schein Pharmaceutical) diluting the from distran with 0.9% sodium chloride for injoction, slowing the infusion time so that administuation occurred coter a hour pariod using the heparin pump on the Cobe 3 mochine to influse the dose only performing test dosing in the hospital acute ariu, and administering muntenance dosing only on those days when the physicians are making raunds in the curpariend while in covectision all interventions were deemed vatuable. The most valuable aspects of the interventions were the inititution of diluting the iron dextran and slowing the rate of infusion to 1 hour.


shows thewell known l-shaped effect of critical broadening, a unique and sharp density-correlated line narrowinghas been observed in the neat state. The gradual switchoff of intermolecular resonance couplings withdecreasing density is responsible for this narrowing phenomenon. [S0031-9007(96)01274-4]