The imbalance of mine pressure is the main cause of various coal mine disasters, and the accurate prediction of rock pressure monitoring data in the working face is of great significance to avoid coal mine disasters. To improve the accuracy of rock pressure prediction, we proposed a rock pressure online prediction model (Attention-BiLSTM) based on a bidirectional long-term and short-term memory network and an attention mechanism. First, the Pauta criteria and K nearest neighbor algorithm are used to preprocess the rock pressure monitoring data. Second, a prediction model based on a BiLSTM and an attention mechanism is constructed, and the model parameters are determined. Finally, the optimization algorithm is used to optimize the weights of the neural network and realize the prediction of rock pressure time series data. Use the root mean square error (RMSE) to evaluate the model,the results show that compared with the model based on RNN, LSTM and BiLSTM,the RMSE of the proposed Attention-BiLSTM model on the training set is decreased by 16.3%,9.3% and 8.9%, respectively, and the RMSE on the test set is decreased by 19.8%, 8.5% and 7.6%, respectively. Thus, Attention-BiLSTM has played a good role in the field of rock pressure prediction in the working face.


The concept of satisfaction is discussed from a psychopathological viewpoint with reference to complete edentulousness or complete dentures. The authors are of the opinion that the evaluation of the results from treatment with complete dentures should allow for subjective and objective appreciations. It is suggested to classify the patients in foundedly satisfied, unfoundedly satisfied, foundedly dissatisfied, and unfoundedly dissatisfied. Suggestions for the treatment of the respective groups are deduced.


BACKGROUND/OBJECTIVES: Elder abuse is a challenging public health issue in need of more robust studies to identify abuse and examine health outcomes following abuse. This study aimed to determine whether elder abuse could predict mortality and disability over the ensuing 12 years. DESIGN: Population-based prospective cohort study of women aged 70-75 in 1996; survival analysis. SETTING: Australia PARTICIPANTS: 12,066 women with complete data on elder abuse MEASUREMENTS: Elder abuse was assessed using the 12-item Vulnerability to Abuse Screening Scale (VASS) subscales: vulnerability, coercion, dependence, and dejection. Outcomes were death, and disability (defined as an affirmative response to 'Do you regularly need help with daily tasks because of long-term illness, disability or frailty?'). RESULTS: In 1996, 8% reported vulnerability, 6% coercion, 18% dependence and 22% dejection. By October 2008, 3488/12066 (29%) were deceased. Increased mortality was associated with coercion and dejection, after controlling for demographics, social support, and health behavior (hazard ratio (HR) and 95% confidence interval (CI) 1.21 (1.06; 1.40) and 1.12 (1.03; 1.23) respectively), but not after adding chronic conditions to the coercion model. Over the 12 years, disability was reported by 2158/11027 women who had reported no disability in 1996. Women who reported vulnerability or dejection were at increased risk of disability, after controlling for demographics, social support, and health behavior (HR and CI: 1.25 (1.06; 1.49) and 1.55 (1.38; 1.73) respectively). The hazard ratio remained significant for dejection when chronic conditions and mental health were included in the model (1.40 (CI 1.24; 1.58). CONCLUSION: This study found that specific components of vulnerability to elder abuse were differentially associated with higher rates of disability and mortality over the ensuing 12 years.


. Desktop Grid is a powerful tool to perform high-throughput computing. Desktop Grid is a form of distributed high-throughput computing system, which uses idle time of non-dedicated geographically distributed computing nodes connected over low-speed network. It has significant differences from computing clusters and computational GRIDs, and needs special operation tackle. In this paper, we present a mechanism for dynamic forecasting of the completion time of a computational experiment in a Desktop Grid. We propose a statistical approach based on the linear regression model with the calculation of a confidence interval, taking into account the accumulation of statistical error and, if needed, changing the forecast. The developed approach is used to implement a forecasting algorithm and software module for a Desktop Grid. We present experimental results based on data from the RakeSearch volunteer computing project.


The substance Tris (or THAM, 2-amino-2-hydroxymethyl-1,3-propanediol, CAS 77-86-1), and its protonated form TrisH + , is used in the preparation of pH buffer solutions for applications in seawater chemistry. The development of an acid-base chemical speciation model of buffer solutions containing Tris, TrisH + , and the major ions of seawater is desirable so that: (i) the effects of changes in the composition of the medium on pH can be calculated; (ii) pH on the free (a measure of [H + ]) and total (a measure of ([H + ] + [HSO4 ])) scales can be interconverted; (iii) approximations inherent in the definition of the total pH scale can be quantified; (iv) electrode pairs such as H + /Cl and H + /Na + can more easily be calibrated for the measurement of pH . As a first step towards these goals we have extended the Pitzer-based speciation model of Waters and Millero (Mar. Chem. 149, 8-22, 2013) for artificial seawater to include Tris and TrisH + , at 25 o C. Estimates of the variances and covariances of the additional interaction parameters were obtained by Monte Carlo simulation. This enables the total uncertainty of any model-calculated quantity (e.g., pH, speciation) to be estimated, as well as the individual contributions of all interaction parameters and equilibrium constants. This is important for model development, because it allows the key interactions to be identified. The model was tested against measured EMFs of cells containing Tris buffer in artificial seawater at 25 o C, and the mean deviation was found to be 0.13±0.070 mV for salinities 20 to 40. Total variances for calculated electromotive forces of the buffer solutions are dominated by contributions from just a few interaction parameters, making it likely that the model can readily be improved. The model was used to quantify the difference between various definitions of total pH and –log10([H + ] + [HSO4 ]) in Jo ur na l P re -p ro of Journal Pre-proof


In subjects with chronic hepatitis B (CHB), the lifetime risk of developing hepatocellular carcinoma (HCC) is estimated to be 25-37 times compared to non-infected subjects. The process of hepatocarcinogenesis is complex and involves well-documented host, viral, and environmental risk factors. The most important risks include host factors such as older age, male gender, the presence of cirrhosis, and viral factors such as the viral load, genotype, and the presence of basal core promoter mutations. To date, antiviral therapy is the only intervention demonstrated to significantly reduce the risk of HCC development in CHB patients. Although oxidative stress has been implicated in cancer development, there is no established benefit shown from treatment with antioxidizing agents such as silymarin, green tea, and vitamin E.


Introduction. Presently, there are no model loads that describe the burst effect of an internal explosion. The goal of the article is to design a model load that characterizes an internal explosion with regard for the effect of inertial safety structures. The author provides relevant examples.Methods. The experiment and the numerical modeling identify the characteristics of an internal explosion, primarily, its destructive effect. First of all, these characteristics include the pressure value and rate in the process of the first peak formation. A drop follows the first peak. Another rise to the second peak is followed by the final pressure drop. The rise to the first peak is described by a cubic parabola. The constant value of pressure is equal to the highest value of the two peaks. It replaces the drop and rise between the peaks. The linear dependence describes the area of the final pressure drop, so that the deformation is completed at the end point. The time of the pressure rise is determined by breakup, and it takes account of the characteristics of safety structures. The time of the second peak is the time when the flame area is maximal.Results and discussion. The deformation that may occur before the first peak represents a solution to the equation, describing the beam motion. This equation is provided in the article. The deformation between the peaks is determined by the balance of energy. The deformation, that occurs when the pressure drops, is identified by the solution to the motion equation. The solution is subject to the deformation completion condition.Conclusions. The results show that the time between the peaks is important when the pressure is close to maximal. The analysis identifies the conditions under which deformation remains elastic. These results can be contributed to the assessment of the bearing capacity of buildings that accommodate explosive production facilities. This approach ensures conservative results.


This paper presents an extension and update of pre- vious calculations of the production by non-exploding Wolf- Rayet stars of radionuclides that could be responsible for cer- tain isotopic anomalies discovered in meteoritic inclusions, or in meteoritic grains of probable circumstellar origin. Quantitative predictions of the time dependence of the ra- dionuclide composition of the wind of Wolf-Rayet stars with initial masses in the wide 25 Mi 120M range and for metallicities 0:001 Z 0:04 are obtained from a set of re- vised stellar evolution models. Special emphasis is put on the radionuclides with half-lives between about 10 5 and 10 8 y that could be produced by neutron captures during central helium burning and ejected during the WC-WO evolutionary phases. We stress that the radionuclide yield predictions are much more secure for Wolf-Rayet stars than for any other potential source of these species that has been contemplated up to now. This re- lates directly to the simplicity of these stars compared to highly difcult to model objects like Asymptotic Giant Branch stars, novae or supernovae. Our abundance predictions are confronted with existing ob- servationaldata,orarehopedtohelpunravellingcasesofpoten- tial interest for further laboratory quest when observations are lacking.Thecaseof 26 Al,ofspecialinterestfor-raylineastron- omy as well as for cosmochemistry, is also briefly revisited. In contrast to the other considered radionuclides, 26 Al is produced during hydrogen burning, and is ejected at the WN evolution- ary phase of the Wolf-Rayet stars. Our computed yields are also usedasthebasisforaqualitativediscussionoftheastrophysical plausibility of the contamination of the protosolar nebula with the radionuclides loading the Wolf-Rayet winds. Our calculations indicate that 26 Al, 41 Ca and 107 Pd can be produced at a level compatible with the observations from a large variety of Wolf-Rayet stars with different masses and ini- tial compositions. Wolf-Rayet stars could also account for the very uncertain limits set on ( 36 Cl)0 and ( 205 Pb)0. In addition, 93 Zr, 97 Tc, 99 Tc and 135 Cs are predicted to be produced in more or less large amounts, but the lack of secure experimental data Send offprint requests to: M. Arnould prevents any meaningful confrontation with the observations. In contrast, the considered stars cannot explain the limits set re- cently on the amount ( 60 Fe)0 of 60 Fe that was live at the start of the condensation sequence in the solar system. Other radionu- clides of interest ( 53 Mn, 92 Nb, 129 I, 146 Sm, 182 Hf, 244 Pu) cannot be produced either during the non-explosive evolution of the Wolf-Rayet stars, but could be synthesized during their even- tual supernova explosion.


Chondrocytes are the cells in articular cartilage (AC) that are responsible for the maintenance of the tissue and remodeling of the extracellular matrix (ECM). ECM molecules, such as collagen and proteoglycan (PG), are synthesized by healthy or normally functioning cells. However, during osteoarthritis (OA), the anabolic and catabolic activity of the chondrocytes is altered, which leads to degeneration of the ECM and changes in the properties of AC. It is known that the mechanical responses of chondrocytes to deformation are also altered during tissue degeneration. However, these studies have been usually performed on a single site or on a few sites of the knee joint. Site-specific responses of chondrocytes to deformation are not known but are important in understanding if and how the mechanical cell responses differ between the various sites within the knee joint. Furthermore, the cell responses to deformation would act as an important control values for future studies. The primary objective of this research was to investigate site-dependent differences in the mechanical behavior of chondrocytes, by studying the volume and dimensional changes (height, width and depth) of the chondrocytes as a result of tissue loading. Furthermore, global tissue strain, local axial and transverse strains were calculated. In order to study the in situ responses of chondrocytes to deformation, a customized indentation device mounted into a confocal laser scanning microscopy was utilized. Samples were harvested from 6 sites in five skeletally mature New Zealand white rabbit knee joints. The sites analyzed included patella, groove and the lateral and medial compartments of both the femoral condyle and tibial plateau. In addition to these cell-level parameters, biomechanical testing was carried out on separate samples to investigate differences in mechanical moduli (equilibrium and dynamic) of cartilage among sites. Differences were found in chondrocyte mechanical responses across the tissue sites. The differences in volume and dimension changes were consistent with the changes in local axial and transverse strains for the different tissue sites examined. In more detail, for each site the cell volume and height were observed to decrease, while


The retention behavior of compounds of antiproliferative activity from the 4-(5-amino-1,3,4-thiadiazol-2-yl)benzene-1,3-diols group by OPLC was investigated. RP-18 stationary phase and five different organic modifiers were used. In the case of ethanol as an organic solvent the highest concentration of water in the eluent can be applied. On the base of the linear relationship between the retention and the concentration of organic solvent, various lipophilicity descriptors were determined. Moderate correlations between the chromatographic parameters and the calculated log P values according to the Villar approach were found. The RMw parameters were compared with the antiproliferative activity of compounds against human cancer cell T47D (breast cancer) to find QSAR equations. The best results for ethanol as the organic solvent were found.


Orientation: South Africa's society can be seen as highly diversified, with linguistic and cultural differences. This diversity has long been a challenge for psychologists using personality measures. Furthermore, social desirability affects the truthfulness of personality measures, as people may present themselves in a more positive light to gain social approval. Research purpose: The purpose of the study is to explore social desirability within the white Afrikaans group (WAG). Motivation for the study: To gain better understanding of how social desirability is understood in the WAG. The South African Personality Inventory project will incorporate the findings (together with other language and cultural social desirability studies), to develop a unified South African social desirability instrument. Research design, approach and method: A qualitative design from a phenomenological approach was used to collect data from the WAG (N = 60). A combined convenience and quota non-probability sampling method was used to study adult white Afrikaans-speaking people. Semi-structured interviews were conducted and content analysis was utilised to evaluate the data. Main findings: Six main themes were identified, which the white Afrikaans-speaking group perceive as socially desirable and undesirable, and feature they will exhibit in order to make a positive impression on others. The six main themes are facilitating, gender-based, intellectopenness, interpersonal relatedness, intrapersonal relatedness and value-based themes. Practical/Managerial implications: From the accumulated data the assumption that can be made is that people, in reasonable terms, demonstrate a need to make a favourable impression on others. If meeting someone for the first time, the need to leave a favourable impression on the person will be intrinsically driven by one's need for social acceptance. Contribution/Value add: Broad understanding of how social desirability is perceived by the white Afrikaans-speaking group, as well as what impression management tactics they will exhibit when seeking to make a favourable impression.


The invention relates to a wrapped gas cylinder rotary shaft hook device. The wrapped gas cylinder rotary shaft hook device comprises a rotary shaft hook and a rotary sleeve, wherein the rotary shaft hook comprises a rotary shaft, an upper semi-circular lug ring, a lower semi-circular lug ring and a pin shaft, PZ. threads are arranged at the left end of the rotary shaft, the upper semi-circular lug ring and the lower semi-circular lug ring which are symmetrical are welded and fixed to the middle of the rotary shaft, a pin hole and a chamfer are formed in the right end of the rotary shaft, and the pin shaft is fixed in the pin hole. The rotary sleeve comprises a short sleeve and a hollow sleeve, wherein the shaft sleeve and the hollow sleeve are welded and fixed, an upper clamping groove and a lower clamping groove which are symmetrical relative to the axis are formed in the right end wall of the hollow sleeve, the pin shaft is in interference fit with the upper clamping groove and the lower clamping groove, and the rotary shaft is in interference fit with a central hole formed in the hollow sleeve.


Since the advent of plant and animal domestication, humans have been alternating the land cover to satisfy their needs. In many developing countries, the forest patterns have been reduced in replacement to non-forest areas such as agriculture land. This study assessed the change in the land cover/use and analysed the deforestation hot-spots of the North Kivu province in the Eastern part of the Democratic Republic of Congo (DRC). Landsat 7 ETM+ and Landsat 8 OLI/TIRS images were used to quantify temporal change between 2001 and 2015. Supervised classification techniques were performed using ArcGIS 10.3 ESRI software and Change Detection was performed with the Remote Sensing software ERDAS Imagine 2014. Getis–Ord (Gi*) spatial statistics tool of ArcGIS 10.3 software was used to identify deforestation hot-spots whose presence was confirmed by the Spatial Autocorrelation (Global Moran I). With reference to forest cover change, the results reveal an overall change, from 2001 to 2015, of 1,381,003 ha (30%) for forest loss and 404,380 ha (9%) for forest gain. The study concluded that agriculture is the major factor impacting 89.66% of the forest loss due to agriculture expansion. It also revealed the presence of hot-spots areas with a Z score of 92 and P-value of 0.0000 especially along the main roads and major towns.


Aim/Study Design/Setting/Participants A descriptive epidemiology study, which aims to describe the distribution and rate of surgical operations performed in professional Australian male cricketers. Methods/Outcome Measures Australian cricket has maintained an injury database since season 1998-99 with surgical details for players inconsistently recorded as part of injury records. This existing database was updated with surgical records from file review of all male players contracted to Australia, Victoria and New South Wales between seasons 1998-99 and 2013-14. The procedures performed on players in these states were used to determine the rate of surgeries per 100 player seasons. The definition of surgery was a cricket-related procedure which required hospital admission (i.e. excluding procedures performed at a cricket ground or clinic like suturing of wounds and excluding hospital admission for a medical illness only).


With the rapid development of our economy and culture and the accelerating transformation of the society,it is very beneficial to introduce professional techniques for social work into student work in universities, innovating education conception,working principle,working techniques,and team construction.


Approximately 6 million patients visit the emergency department (ED) each year with complaints of chest pain, constituting 9% of all patients seen in EDs in the United States. Over the last 10 years, the total number of ED patients with noninjury complaints increased by 22%, whereas the percentage of patients with chest pain decreased slightly. Chest pain is a symptom caused by several life-threatening diseases and has a broad differential diagnosis. It is complicated by a frequent disassociation between intensity of symptoms and signs and seriousness of underlying pathology.


Lebrikizumab (LEB) is a high-affinity monoclonal antibody targeting interleukin (IL)-13, preventing IL-13 signalling via the IL-4Rα/IL-13Rα1 receptor complex. Here, we report 16-week efficacy and safety outcomes of LEB monotherapy in patients with moderate-to-severe atopic dermatitis from two 52-week, randomized, double-blinded, placebo-controlled phase III trials, ADvocate1 (NCT04146363) and ADvocate2 (NCT04178967). Eligible adults and adolescents (aged 12–17 years, weighing ≥ 40 kg) from ADvocate1 and ADvocate2 were randomized (2 : 1) to subcutaneous LEB 250 mg (500 mg loading dose at baseline and week 2) or placebo every 2 weeks (Q2W). Efficacy analyses included proportions of patients achieving Investigator's Global Assessment (IGA) 0/1 and Eczema Area and Severity Index (EASI)-75 (coprimary endpoints), EASI-90, and pruritus numeric rating scale (NRS) ≥ 4-point improvement from baseline to week 16. This was a pooled analysis of ADvocate1 and ADvocate2, where IGA 0/1 and EASI-75 and EASI-90 were analysed in 564 and 287 patients (LEB 250 mg and placebo), respectively, and pruritus NRS in 516 and 264 patients, respectively. Cochran–Mantel–Haenszel with Markov chain Monte Carlo multiple imputation was performed. Patients treated with LEB 250 mg and placebo for 16 weeks achieved, respectively, IGA 0/1 response rates of 38.1% (n = 215) and 11.7% (n = 34; P < 0.001); EASI-75 responses of 55.4% (n = 313) and 17.2% (n = 49; P < 0.001); EASI-90 responses of 34.5% (n = 195) and 9.2% (n = 26) (P < 0.001); and pruritus NRS ≥ 4-point improvement responses of 42.9% (n = 221) and 12.2% (n = 32; P < 0.001). The percentage of patients reporting one or more treatment emergent adverse event(s) was lower in the LEB group (49.6%) than in the placebo group (59.0%; P = 0.009). These data suggest that LEB 250 mg Q2W for 16 weeks is an efficacious and safe treatment option for adult and adolescent patients with moderate-to-severe atopic dermatitis.
 Funding sourcesThis study was funded by Dermira, a wholly owned subsidiary of Eli Lilly and Company. Almirall has licensed the rights to develop and commercialize lebrikizumab for the treatment of dermatology indications, including atopic dermatitis, in Europe. Lilly has exclusive rights for development and commercialization of lebrikizumab in the United States and the rest of world outside Europe.


Objective:To assess the efficacy and safety of different acupuncture methods for vascular dementia.Methods:Search all papers of acupuncture in treatment of vascular dementia randomized controlled trials,and evaluate the literature quality.Results:For including the 14 RCT studies,Jadad score and clinical efficiency has the Meta-analysis:electro-acupuncture with western medicine,the control group,95% CI [1.86,4.64],P0.00001;needle drug use to cope with a simple needle spines have efficiency,aggregate OR 1.29(95% CI 0.23,7.38);injections with the control group with western medicine,summary OR 5.55,(95% CI 1.69-18.16).Conclusion:The electricity for patients with vascular dementia improve overall efficacy has satisfactory results,other needle because the smaller sample size,further studies are needed.


In launching the commission on Language Difficulties, Patrick helped to realize in practical terms the difficulties which teachers have in becoming learners. Rather than delivering a paper on language deprivation, he encouraged the members of the commission to consider what was involved in a particular learning situation, and the constraints which operate upon it. He has kindly allowed English in Education to print some extracts from a tape-recording made at this session, though inevitably something of the original spontaneity is lost in print.


Exhaled breath condensate (EBC) has been proposed as an alternative non-invasive biological sample for therapeutic drug monitoring. In this study, a sensitive method for the quantification of deferiprone (DEF) in EBC samples was developed using a silver nanoparticle (AgNP)-enhanced terbium (Tb3+) fluorescence method. Fluorescence properties of the Tb3+–DEF complex were studied in the presence of AgNPs in EBC. Effects of various parameters such as AgNPs and Tb3+ concentrations, pH, and buffer concentration were studied. A calibration curve was obtained with a coefficient of determination (R2) of 0.999, and linearity was observed in the concentration range of 0.06–1.50 mg L−1. The method was successfully applied for the quantification of DEF in sixteen patients with very low concentrations (0.06–0.17 mg L−1) in the EBC samples.


After reviewing the surgical reports of 2,000 female sterilizations by laparoscopy done in a one-year period we found a total incidence of operative complications of 3.9%. Hemorrhage was the most frequent complication (2%). There was a low incidence of bowel burns (0.15%).


This paper is about the introduction to the technological flow, equipment features and technical parameter of 200t/d APMPproduction line introduced from ANDRITZ Company by Qiqihaer Paper Co., Ltd. Optimization of screw press is especially discussed indetail.


Mathjax On | Off Abstract Image enhancement is processing aimed at assisting professional image analysis and facilitating image-based decision making. MATLAB® source files for the exercises are available from chapter 1.


There is an increasing body of evidence demonstrating that elevated growth signaling in breast cancer cells can promote forms of endocrine resistance in either an estrogen receptor-dependent or -independent manner. The current article reviews what is known about such growth factor signaling networks and resistance to estrogen withdrawal and considers the many novel therapeutic opportunities that stem from this knowledge.


Abstract : The American Civil War was similar to other wars in America's history in that both sides employed irregular warfare during operations. Confederate partisan units utilized irregular warfare to interdict Union Army operations in northern Virginia and the Shenandoah Valley for the duration of the conflict. These partisan units were hybrid organizations that conducted independent raids, small skirmishes, and reconnaissance in support of the larger Confederate Army. Union Army operations to counter these partisan units achieved differing levels of success throughout the war. However, the Union Army developed and employed unique counter partisan organizations during 1864 with increased success. This thesis examines the 43d Virginia Cavalry and the 1st Virginia Partisan Rangers of the Confederate Army, and the Union Army's response to counter the irregular partisan units. The thesis adds specific emphasis on the Union Army's development and employment of hybrid independent scout organizations. Enhanced capabilities, specifically in the domains of leadership, personnel, training, and material, enabled these independent scouts to employ irregular warfare in countering Confederate partisan operations. Examination of these counter partisan units demonstrates the importance of understanding an adversary's capabilities, tactics, and other aspects of the operational environment.


The roles of microscopic plasma instabilities on the violation of the frozen-in constraint are investigated by examining the force balance equation based on explicit electromagnetic particle simulation for a thin current sheet. Wave-particle interactions associated with lower hybrid drift instability and drift kink instability (DKI) contribute to the wavy electric force term at the periphery of the current sheet and the wavy magnetic force term at the neutral sheet, respectively. In the linear growing phase of DKI, the wavy magnetic force term balances with the electric force term due to the dc electric field at the neutral sheet. It is concluded that the growth of DKI can create anomalous resistivity and result in the violation of the frozen-in constraint as well as the diffusion of current density.


We analyze the $\ensuremath{\beta}$-functions of Yukawa and electromagnetic theories with Lorentz violation (LV) and propose an alternative method to find the scale dependence of the different fields that parametrize such violations. The method of solution consists of decomposing a family of parameters into their irreducible representations and thus generating a group of subfamilies that obey the same symmetries and transformation rules. The convenience of this method relies on the fact that the degree of complexity of the problem is reduced in the decoupling process. For a set of parameters describing a Lorentz-violating theory, we expect their associated $\ensuremath{\beta}$-functions to be non-negative or, otherwise, their scale dependence weak enough. These conditions are necessary because asymptotically free parameters could leave high imprints of LV at low energies, which are ruled out by observations. Besides imposing some constraints on the coefficients that describe LV, this method can be used to find the fixed points of the theory in each particular irreducible subspace.


In Bangladesh, the UN Population Fund is working to strengthen nongovernmental organization (NGO) capacity and linkages to improve reproductive health services and information. Specifically, the aim is to strengthen the technical and human resource capacity of participating NGOs and the functional linkages between national NGOs and relevant government agencies to help harmonize and standardize the delivery of reproductive health information and services. This umbrella project collaborates with RHI-participating NGOs in a policy paper on adolescent reproductive health, and will maintain contact with the regional dimension project to collaborate its activities. Programs implemented by partner NGOs are being reviewed and monitored, and linkages among national NGOs and government agencies are being developed. The main activities of the project are enumerated.


This paper introduces a model‐driven approach to the design of collaborative Web‐based applications, i.e. applications in which several users play different roles, in a collaborative way, to pursue a specific goal. The paper illustrates a conference management application (CMA), whose main requirements include: (i) the management of users profiles and access rights based on the role played by users during the conference life cycle; (ii) the delivery of information and services to individual users; (iii) the management of the sequence of activities that lead to the achievement of a common goal. The presented approach is based on WebML, a conceptual modelling language for the Web. The paper also highlights some general properties—as understood by the practical experience of CMA development—that a Web modelling language should feature in order to fully support the development of collaborative applications. Copyright © 2003 John Wiley & Sons, Ltd.


In 1938 a 13-year-old girl presented with a 4 cm lump on the left side of her face just below the left ear, which had slowly increased in size for the previous 18 months. The lump was described as being hard and knobbly and quite immobile. It was excised and histology showed that it was a mixed parotid tumour showing considerable hyperplasia and thought to be locally malignant. She then underwent a two months' course of orthovoltage irradiation. Unfortunately, details of the prescription were destroyed during the war. Four years later she developed a 1 cm nodular recurrence just below the operation scar. This was kept under observation for three years when two further discrete swellings were noted. The upper one was just posterior to the mandible and a lower one inferior to it. Both swellings were mobile and unattached to superficial or deep structures. Surgical removal was performed and histology again showed that this was a mixed parotid tumour. Within three months she had developed another 1 cm recurre...


Acute Respiratory Distress Syndrome (ARDS) is a major cause of morbidity and has a high rate of mortality. ARDS patients in the intensive care unit (ICU) require mechan-ical ventilation (MV) for breathing support, but inappropriate settings of MV can lead to ventilator induced lung injury (VILI). Those complications may be avoided by carefully optimizing ventilation parameters through model-based approaches. In this study we introduced a new model of lung mechanics (mNARX) which is a variation of the NARX model by Langdon et al. A multivariate process was undertaken to deter-mine the optimal parameters of the mNARX model and hence, the final structure of the model fit 25 patient data sets and successfully described all parts of the breathing cycle. The model was highly successful in predicting missing data and showed minimal error. Thus, this model can be used by the clinicians to find the optimal patient specific ventilator settings.


Saloman et al. (Salomon, M., L. G. Kroon, R. Kuik, L. N. Van Wassenhove. 1991. Some extensions of the discrete lotsizing and scheduling problem. Management Sci. 37 801--812.) claim the NP-completeness of different variants of the discrete lot-sizing and scheduling problem (DLSP) which are differentiated by using a six-field notation. However, some of the given proofs are incorrect because the transformations employed map certain data values of the preimage problem to the number of data in the resulting instance and are hence not polynomial. As an example, we concentrate here on the 1/*/SI/G/A-optimization problem (Salomon et al. [Salomon, M., L. G. Kroon, R. Kuik, L. N. Van Wassenhove. 1991. Some extensions of the discrete lotsizing and scheduling problem. Management Sci. 37 801--812.], Theorem 3). Similar arguments pertain to the 1/*/A/G/SI-DLSP, too.


The control of uncertain systems has become an area of recent interest. The basic control techniques have been modified to work well in presence of perturbations. This paper presents a geometric relationship of performance specifications to pole assignment. The design freedom has been used in optimizing various cost functions for performance. Robustness issues have been incorporated in the design for specified ranges of parametric perturbations. An example has been included to illustrate the procedure and effectiveness of robust control design.


In the network and digital technology environment,the copyright protection of the information resources has increasingly become the focus of people's attention.The authors use the basic principles of game theory to make some analysis on information resources copyright system and stress the necessity to improve the system of copyright protection.Some measures such as ceiling the price of information works,strengthening the network monitoring,increasing the punishment,reducing the cost on safeguarding the rights,looking into the indirect responsibility of technology providers are given out.


Invasions of North American grasslands by Spotted knapweed (Centaurea maculosa Lam.) are mediated in part by Spotted knapweed root exudation of (±)‐catechin, a potent phytotoxin. Residual soil (±)‐catechin may interfere with reestablishment of native grassland species even after Spotted knapweed populations are controlled. Grassland species that are resistant to (±)‐catechin may be more successful for restoration of areas infested by Spotted knapweed. We evaluated the (±)‐catechin resistance of 23 grassland species by measuring the effects of seven (±)‐catechin concentrations (0–4.0 mg/mL) on seed germination, seedling root and shoot elongation, and seedling mortality. (±)‐Catechin treatments were chosen to reflect the range of observed Spotted knapweed field soil (±)‐catechin concentrations. Inhibition of root elongation was the strongest and most common effect of (±)‐catechin treatment. High (±)‐catechin concentrations reduced mean root lengths of 5 of the species by more than 75% and another 10 species by more than 55%. Experimentally derived concentrations needed to reduce root length by 50% (EC50), an indicator of (±)‐catechin resistance, ranged from 0.43 mg/mL ± 0.30 SE to greater than 4.0 mg/mL among species. Eight species with EC50s greater than 3.0 mg/mL were identified as resistant to (±)‐catechin and are likely suitable for revegetation of Spotted knapweed–infested areas. (±)‐Catechin resistance was positively correlated with mean seed mass, suggesting that seed carbohydrate reserves may allow seedlings to detoxify (±)‐catechin, develop barriers to (±)‐catechin exposure, or sustain a positive growth rate, despite (±)‐catechin‐induced cell death. Future efforts to identify allelochemical‐resistant grassland species should focus on large‐seeded species.


In view of the problems in investment accounting after implementing the new Accounting Policy and new Income Tax Law,income tax accounting methods of Long-term investments-stock and long-term invest-bonds are illustrated according to the purpose of management.The differernces between two investments are analysed for reference.


A multi layer printed circuit board and a method of fabricating the same are provided to improve adhesion reliability between a paste bump and a circuit pattern through increase of a contact area therebetween by surrounding and filling up the circuit pattern with the paste bump. A multi layer printed circuit board includes a first substrate and a second substrate, a fourth insulating layer, and a paste bump(40). The first substrate includes first inner layer circuit patterns(16) on both surfaces of a first insulating layer(12), a second insulating layer(14) with second inner layer circuit patterns(18) on the both surfaces of the first insulating layer, and a first via hole passing through the first and second insulating layers. The second substrate includes third inner layer circuit patterns(36), outer layer circuit patterns(52), and a second via hole(50). The third inner layer circuit patterns are formed on positions of one surface of a third insulating layer(32) which face a part of the second inner layer circuit patterns. The outer layer circuit patterns are formed on the other surface of the third insulating layer. The second via hole electrically connects the third inner layer circuit pattern and the outer layer circuit pattern. The fourth insulation layer is built-up between the first and second substrates. The paste bump surrounds and fills up the third inner layer circuit patterns and is connected to the second inner layer circuit patterns by passing through the fourth insulating layer.


THE TERMINAL DESIGN PROCESS WITH CASE STUDIES OF HACTL'S CONSOLIDATED AIR CARGO TERMINAL AT HONG KONG AIRPORT, EMERY'S HUB AT DAYTON AND THE SINGAPORE AIRPORT TERMINAL SERVICES


Information asymmetry increases the risk of incorrect selection of market participants. As shares in hands of shareholders with private and confidential information increases, the company's stock liquidity reduces, because traders holding stocks with high information asymmetry and high liquidity risk can hardly earn abnormal profits. According to the fact that investors select their desired assets with regard to the return and risk of investment, when the risk of asset increases, investors will expect more profit. This study examines the effect of disclosure of accounting information and information asymmetry on risk of liquidity in companies accepted in Tehran Stock Exchange. To reach this goal a hypothesis has been developed. Studied sample includes 61 companies accepted in Tehran Stock Exchange during the period of 2010 to 2014. To measure the research variables, given that the type of data is combinational, panel regression has been used and for measuring of illiquidity of stocks Amihud model (2002) has been used. The findings show that information asymmetry has a direct impact on stock liquidity risk.


This investigation has clearly established the fact that, for sections built up of straight line elements, theoretical calculations can be made with a degree of accuracy sufficient for practical application and will be on the conservative side.

Co-author: Wallace M. Beakley.


Abstract Whitehead, Process Philosophy, and Education by Robert S. Brumbaugh. Albany: State University of New York Press, 1982, 145 pages, notes, $30.50 hardback, $9.95 paperback.


This paper is an analysis of the most important mathematical aspects of medical diagnosis: logical probability, rationality and decision theory, gambling models, pattern analysis, hazy and fuzzy subsets theory and, finally, the stochastic inquiry process.


Thank you very much for downloading building global biobrands taking biotechnology to market. As you may know, people have search numerous times for their favorite books like this building global biobrands taking biotechnology to market, but end up in harmful downloads. Rather than reading a good book with a cup of coffee in the afternoon, instead they juggled with some malicious virus inside their computer.


Awareness of Chronicles as a work in its own right has raised issues of literary design and so questions of structural patterns and units. Thus M.A. Throntveit has detected in Chronicles a process of literary periodization whereby the united monarchy of David and Solomon (1 Chron. 10-2 Chron. 9) is followed by the divided monarchy (2 Chron. 10-28) and then by a reunited monarchy (2 Chron. 29-36).~ Developing an insight of O. P16ger concerning the second period,2 he has found objective evidence for these three periods in the strategic placing of royal speeches.3 On a smaller scale, chiastic patterns have been discovered in substantial stretches of material. H.G.M. Williamson has interpreted the genealogy of Judah in 1 Chron. 2.3-4.23 in such terms.4 4


This research examines the effects student jobs have on the study performance, and the competency and career development of hospitality management students. A 13-item survey was administered to a sample of 82 hospitality management students to see how they think about their student job. Qualitative data was collected by a focus group interview with hospitality entrepreneurs. The sample consisted of 48 MHS students and 34 HHS students. 78,8% of the respondents think a student job is useful for their study. For nine students, the student job affects school results. 63 students think they will find a future job easier because they have had a student job. The average of worked hours per week has a minimum of 3 and a maximum of 40 hours per week. Of all collected data, it can be concluded that having a student job is beneficial for the study performance, competence and career development of hospitality management students. A recommendation for Mise en Place is to put more focus on hiring hospitality management students. They tend to stay longer in the company because they gain knowledge, skills and experiences which are very useful and well-linked to their study and career.


Using a critical hemispheric indigenous framework to analyze my interviews and participant observation work, I argue that indigenous women's challenges to expected gender norms reinforce and solidify comunalidad and sense of belonging and being indigenous to their community. Based on qualitative and ethnographic fieldwork in Los Angeles I show that belonging to Zoochina and being Zoochinense is taught and practiced in traditional dances, being in the Oaxacan brass band, and as a member of the hometown association. To do this, I consider the indigenous Oaxacan conception of collective community life— comunalidad— in order to understand current forms of community participation in Los Angeles (Luna 2013). I coin the term "transnational comunalidad," of which I define as, the indigenous ideology and practice of communal belonging and being across generations in diaspora. In looking at indigenous Latinas/os across generations, my work reveals the multicultural and multiethnic processes by which the indigenous diaspora navigates belonging and identity in the U.S.


Change: it's often the most difficult thing to accept. Most of us have the belief that we are who we are and we shall not be moved But what if everything around you is changing? What if the saying 'adapt or die' is true? Then it is time to embrace change as Judy Fredericks did.


Various hypotheses have been advanced in explanation of the pain in duodenal ulcer. This pain has been ascribed to irritation of exposed nerve endings in the ulcer base by the acid gastric juice, or to sensitization of the pain-producing mechanism in some way by acid. Bonninger, 1 Palmer 2 and others hold such views. Mechanical irritation by coarse particles of food is the cause assigned by Pick. 3 Spasm of the pyloric sphincter or of the duodenal cap has been put forward by Glaessner and Kreuzfuchs 4 and many others. Tension, due to an inhibition of relaxation of the pyloric sphincter, combined with strong gastric peristalsis, has been advanced by Hurst 5 as the cause. That distention of the stomach is an important element in the pain of gastric ulcer and that this pain is readily relieved by passing a tube into the stomach is stated by Poulton. 6 That the pain is possibly due to


Large number of joint intersections along expressway increase conflicts for vehicles,which lead to the decreasing of speed and traffic capacity and service level with increasing of accidents.Therefore,it is necessary to analyze quantitatively the smallest distance between intersections from the point of running inspection distance,and present travelling visual distance so as to provide technique foundation for examining and approving of highway administering departments.


GRAPHICAL ABSTRACT Abstract This mini review summaries applications of N-sulfinyl imine derived β-amino carbonyl compounds, Mannich bases, for the asymmetric synthesis of heterocyclic alkaloids, including piperidines, quinolizidines, indolizidines, tropinones, and homotropinones, using the intramolecular Mannich cyclization reaction.


This letter reports UV ozone cleaning of Si substrates for obtaining defect‐free molecular beam epitaxial films by low‐temperature in vacuum preheating. By using UV ozone cleaning, the high temperatures above 1200 °C required for removing surface carbon in the conventional method can be significantly lowered to below 1000 °C, since the UV ozone cleaning functions to remove carbon.


We report the unusual photoluminescence (PL) properties of vertically aligned InN nanorod arrays grown on Si(111) with a Si3N4 buffer layer. The optimum growth conditions of InN nanorods are obtained by controlling the III/V ratio and the growth temperature. Structural characterization by X-ray diffraction and scanning electron microscopy indicates that individual nanorods are wurtzite InN single crystals with the growth direction along the c-axis. Near-infrared PL from InN nanorods is clearly observed at room temperature. However, in comparison to the PL from InN epitaxial films, the PL from InN nanorods is significantly lower in efficiency and exhibit anomalous temperature dependence. We propose that these unusual PL properties are results of considerable structural disorder (especially for the low-temperature grown InN nanorods) and strong surface electron accumulation effect. (© 2007 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim)


Despite extensive literature on the linkages between sustainability and resilience, conceptual understanding of the capacity of urban infrastructure systems to support higher population densities remains unclear. In response, this paper presents a framework to illustrate the fundamental relationship between infrastructure capacity and density at the building scale. We explore the density and resilience paradigm by developing the "Infrastructure Carrying Capacity" (ICC) framework to calculate the concentration of resource demand (or consumption) that can be "carried" by the building envelope and supporting infrastructure systems i.e. the demand density. In this regard, the ICC framework can be used to calculate the building's natural carrying capacity. Furthermore, applying the ICC framework at the building scale provides a strong foundation for potential replication and scale-up to the neighborhood or city scale. Overall, our research develops a basis for re-thinking urban sustainability and resilience in the context of rapid population growth and changing demand pressures.


Various modeling approaches used for controlling a continuous digester are discussed: the Kappa control uses an approach based on modeling the reaction kinetics; an automatic grade change uses gain scheduling; and the level control uses an adaptive time series model. The strengths and weaknesses of each technique are discussed along with guidelines on model selection. The author's experience with each technique and implementation considerations are also covered.


We need less, but better, research, done for the right reasons. Douglas Altman of the UK's Imperial Cancer Research Fund considers that too much poor medical research is published in medical journals. Methodological weaknesses, use of wrong techniques, use of the right techniques but for the wrong purposes, misinterpretation of results, selective reporting of results, selective literature citation and unjustified conclusions are common phenomena, misleading public opinion. Statistical dishonesty brings with it risks for public welfare. Pressure to publish, whether to promote one's personal career or the finances of an institute, is one of the causes of the current increase in scientific fraud. The length of one's publication list is, all the same, a dubious indicator of an ability to do good research. Another problem is that doctors have too little knowledge of statistics or even of the basic principles underlying sound methods of research. It seems to be widely considered acceptable for medical researchers to be ignorant of statistics.


The main problem faced by the specialists of education management in determining the goals of regulation and development of students' research activities is the imperfection of the evaluation mechanisms of scientific training at the university. The model includes the development of motivational, activity and evaluation components. This article focuses on the design of assessment component of students' research activities. Assessment component of pedagogical system under consideration, i.e. in a technical university, includes the proposed results and the criterion indicators; mechanisms for diagnosis and improvement methods of students' research activities. As projected results there may be: a model of high school graduate, the place of research competence in it, a model of research competence, a model of the scientific information environment of high school (resource potential). Depending on this, criteria indicators can serve as an increment of competencies in the composition and performance as well as resource potential of students research work. The purpose of the proposed research is to develop a mathematical model of research activities effectiveness of the technical students. This article discusses the possibility of using the conceptual and methodological apparatus of pedagogical qualimetry in studying the process of scientific training of students. In the article the possibilities of using pedagogical qualimetry terms and methodology in the study of students' research process are observed. Diagnostics technique is offered to evaluate the efficiency of technical university students' research efficiency. The result and index of students' research system development are specified. As a result of the experiment, main components of students' research competence and their weighting values are revealed. Linear mathematical model which allows diagnosing student's research efficiency is constructed. Minimum (L min = 33.75), maximum (L max = 101.25) and threshold values of diagnostic assessment and their indicators are presented. This model is a basis for the test software which can be used further in practice.


The occurrence of the invasive Brown anole, Anolis sagrei from the Pacific coast of Mexico is confirmed based on squamation and the use of morphological characters. A PCA was performed to explore the morphological differences between the invasive anole and the native Clouded anole Anolis nebulosus. Some of the potential implications for dry tropical ecosystems and native anoles are discussed.


We present a local approximation to total energy tight binding (TB) designed to be suitable as a semiempirical potential form for covalent and metallic-covalent materials. Chebyshev polynomial moments of the Hamiltonian matrix are generated in a stable and efficient manner through recursive matrix-vector multiplies. The electronic density of states is approximated by a Chebyshev polynomial expansion with Gibbs damping which maintains positivity. The scaling of the computational work is made linear in the number of atoms by truncating the moment computation at a certain range about each atom. Energy derivatives necessary for molecular dynamics are obtained from a matrix-polynomial derivative relation. The method converges to exact TB as the number of moments and the truncation range are increased. The convergence properties are tested on silicon.


This article introduces the concepts of streaming media and streaming media techniquc,andbingsup solution of the streaming media.In the end gives an example to show the application of streaming media technique in library.


At the request of the government information openness,tax authorities actively fulfill its obligations of open taxation information. But at the same time,protecting the taxpayers' private information is the responsibility of tax authorities and their staff. However,this will cause conflicts between taxation information disclosure and taxpayers private information protection,and also cause legal disputes between taxpayers and tax authorities. Therefore,one must rethink the protection institution of taxpayers' private information in the context of taxation openness,and provide advices for the improvement.


Relative to formerly abused women, chronically abused women had more traditional attitudes about women's roles, had lower self-esteem, felt more controlled by outside forces, were less educated, and were less likely to be employed or to receive counseling. Based on a screening interview, 46 female clients were assigned to either a chronically abused or formerly abused group. Results support the hypothesis that a woman's decision to remain in a long-term abusive relationship is, in part, a rational decision based on the perceived relative rewards and costs of the relationship, the size of investments made in the relationship, and the perceived quality of alternatives to the abusive relationship (M. J. Strube and L. S. Barbour; see record 1984-18040-001). (PsycINFO Database Record (c) 2012 APA, all rights reserved)


In general, the author concludes that extensive reading of scientific literature serves to increase individual achievement in general science and contributes to the scientific attitude of the individual, although in the latter case the improvement is not so large as might be secured from a small amount of class time devoted specifically to the teaching of scientific attitudes. The Appendix contains alphabetically arranged lists of scientific terms, radio terms, and scientific interests which were secured in the course of the experiment. A brief bibliography is given. The study is open to the criticism that a large part of the data is based on questionnaires which require subjective answers. It is possible that the last three of the questionnaires were answered in terms which the individuals thought would be pleasing to the experimenter. Forty-two parents were asked for an evaluation of the experiment, and only seventeen replied. While the replies received were gratifying, the opinions of the twenty-five parents who were not interested enough to answer are a matter of uncertainty. The experiment at least indicates the need for further investigation of the very important problem of extensive reading. CARTER V. GOOD


AN INVESTIGATION INTO THE PHYSIOLOGICAL ROLE OF ANNEXIN A11 A. Tomas and S.E. Moss Division of Cell Biology, Institute of Ophthalmology, University College London, London (UK) Annexin A11 is a calcium-dependent phospholipid-binding protein that interacts in vitro with the EF-hand protein, Calcyclin. It is broadly distributed and has the longest N-terminal domain (197 aa) of all known annexins, which contains the binding site for Calcyclin. This unique N-terminal domain is alternatively spliced generating two different isoforms that differ in their capacity to bind to Calcyclin. Since Calcyclin is overexpressed in tumor cells with the mRNA levels specifically increased in the G1 phase of the cell cycle, it is possible that the Annexin A11-Calcyclin complex may play a role in cell proliferation and division. Annexin A11 is also known to be a target for cellular Ser/Thr and Tyr-kinases, suggesting that phosphorylation could regulate Annexin A11 function in living cells. Annexin A11 may also be involved in calciumregulated secretory processes, as it has been localised to various types of neutrophil-specific and insulin granules, and antibodies against Annexin A11 inhibit calcium-dependent insulin secretion. We employed a number of different approaches to provide insights into the physiological function of Annexin A11. Using immunofluorescence techniques, we investigated the subcellular localisation of Annexin A11 in the human cell line A431. We followed Annexin A11 localisation throughout the cell cycle, and its relocalisation in response to changes in the intracellular calcium levels. We studied the levels of tyrosine phosphorylation of Annexin A11 in response to several agonists, and are currently deriving an annexin A11 knock-out in the chicken DT40 cell line. We are also overexpressing either the aminoor the carboxy-terminal domain of human Annexin A11 to assess any potential dominant negative effects in vivo. THE ROLE OF ANNEXIN A5 IN APOPTOSIS B. P. Young, T.E. Hawkins and S.E. Moss, Division of Cell Biology, Institute of Ophthalmology, 11-43 Bath Street, London (UK) The annexins are a family of ubiquitously expressed Ca-dependent phospholipid binding proteins which have been implicated in a variety of cellular processes, including vesicle trafficking and Ca channel activity. To help improve our understanding of the physiological roles of the annexins, we have knocked out the annexin A5 gene in the DT40 chicken pre-B cell line. Anx5 cells are viable, yet display several phenotypes, the most striking of which is resistance to drug-induced, Ca-dependent apoptosis. In contrast, Anx5 cells are still susceptible to apoptosis induced by irradiation with UVA/B light. To further understand the role of annexin A5 in apoptosis, a number of strategies are being employed. The degree to which Anx5 cells are resistant to apoptosis is being analysed by thorough kinetic experiments, which will determine whether Annexin A5 merely delays the onset of apoptosis or completely inhibits it. Using recently developed direct protein delivery techniques, recombinant Annexin A5 can be introduced into cells at different levels in both wild type and knockout cells, and the subsequent effects on apoptosis susceptibility monitored. One possibility is that knocking out annexin A5 may have altered the expression of other genes involved in the apoptotic process. To investigate this, the levels of known apoptotic proteins are being analysed at the protein and mRNA level, as well as a more thorough analysis of gene expression using subtractive PCR methods. Finally, live cell imaging using GFP-tagged Annexin A5 is being utilised to investigate whether Annexin A5 relocalises in response to apoptotic stimuli.


Single-carrier frequency domain equalization (SC-FDE) has been standardized as an alternative of orthogonal frequency division multiplexing (OFDM) in IEEE 802.11ad and 802.15.3c. In addition, with the use of low density parity-check (LDPC) codes, multi-Giga bits transmission can be supported in 60-GHz millimeter-wave (mmW) WLAN/WPAN with desired decoding complexity. In this paper, we present and evaluate an enhanced log-likelihood ratio (LLR) calculation method to facilitate the LDPC decoding in SC-FDE. In contrast to the virtual channel (VC) based LLR calculation approach (i.e., the Unique Word (UW) tracking scheme), our proposed method exhibits better bit error rate (BER) performance, and is more spectrally efficient.


The goal and reform necessity o"fchain"teaching mode were elaborated in view of the charac-teristic of software platform courses.Components of this mode and its concrete implementation plan were proposed.A case study was made of 3 courses of the same kind including J2EE platform by adopting"close link between teaching and practice".Results show that this mode which expresses engi-neering ability-oriented teaching concept enhances students' software engineering ability and practical ability.


This is a revised version of a lecture originally given by Sir Robin at the Sixth Judicial Colloquium on the Domestic Application of International Human Rights Norms, held at Bloemfontein, South Africa, on 3-5 September 1993. Sir Robin discusses the New Zealand approach to freedom of expression and non-discrimination. He first outlines the place of the New Zealand Bill of Rights Act 1990 within New Zealand's constitutional framework. He then assesses New Zealand's approach to freedom of expression under the NZBORA and Bill of Rights 1689, drawing on major decisions concerning media freedom and parliamentary privilege, TV3 Network Ltd v Eveready New Zealand Ltd [1993] 3 NZLR 435, Television New Zealand Ltd v Prebble [1993] 3 NZLR 513, and the Spycatcher litigation reported at [1988] 1 NZLR 129. Sir Robin then analyses New Zealand's approach to anti-discrimination under the NZBORA and the Human Rights Act. He concludes by considering several Treaty of Waitangi cases, in particular Te Runanga o Wharekauri Rekohu Inc v Attorney-General [1993] 2 NZLR 301 (the Sealord case), as potential examples of positive discrimination. Abstract written by Tim Cochrane


A BiCMOS logic circuit applicable to sub-2-V digital circuits has been developed. A transiently saturated full-swing BiCMOS (TS-FS-BiCMOS) logic circuit operates twice as fast as CMOS at 1.5-V supply. A newly developed transient-saturation technique, with which bipolar transistors saturate only during switching periods, is the key to sub-2-V operation because a high-speed full-swing operation is achieved to remove the voltage loss due to the base-emitter turn-on voltage. Both small load dependence and small fan-in dependence of gate delay time are attained with this technique. A two-input gate fabricated with 0.3- mu m BiCMOS technology verifies the performance advantage of TS-FS-BiCMOS over other BiCMOS circuits and CMOS at sub 2-V supply. >


This research study identifies and evaluates the strategies applied in the transformation of Clark Air Base ("CAB") in the Philippines, once the biggest air base outside of the United States (US) into a financially viable and competitive global Property Management -Economic Zone Development ("PM-EZD") in order to derive insights for a template for overseas bases facing closure. Capitalizing on its locational advantages as military base (strategic location, land availability and suita- bility, infrastructure development), CAB used the strategies of ease of doing business, zone administration and management, competent work force, cost doing business, investment incentives and political stability to further enhance its competitive- ness. Multiple Regression Analysis results showed that competent work force and cost of doing business registered high relationships with investments generated; zone administration and management and ease of doing business, moderate while investment incentives, weak. Sequential Equation Model ("SEM") results point to the effectiveness of ease of doing business (-.000); zone administration (.0007); work force (-.016); Infrastructure Development (-.016) cost of doing business (-.024) and investment incentives (-.0.29).. Confirmatory Factor Analysis showed the following results: Work Force (0.948); Ease of Doing Business (0.94); Zone Administration and management (0. 911); Political Stability (0.861); and Investment Incentives (0.818).


This study examines the effect of traffic density on the occurrence of collisions caused by driver fatigue. Selected motorways, dual carriageway and single carriageway roads were considered at a range of traffic flows over a 2-year period in the UK. The primary data were collected from police accident report forms, witness statements, police statements and postal questionnaires. Reports from accident investigation units were also included. It was found that 17% of the 1828 accidents causing death or serious injury were sleep-related. The percentage of sleep-related accidents was highest on the M40 motorway and lowest on the A19 single carriageway. 85% of the sleep-related accidents were caused by men and 15% by women. Young male and female drivers were at much higher risk than older drivers. The rate of sleep-related accidents per mile per year was positively correlated with traffic density (as were all accidents). On motorways the relationship between higher traffic density and sleep-related accidents did not hold true, possibly because the additional vehicles created a more interesting driving environment.


12020 Background: Chemotherapy-induced peripheral neuropathy (CIPN) is a common dose-limiting complication of cancer treatment that can negatively impact survival and quality of life. Cannabidiol (CBD) has been shown to attenuate CIPN in rodent models although its ability to reduce CIPN symptoms in humans is unexplored. Methods: A phase 3 randomized double-blind, placebo-controlled clinical trial was conducted between 6/1/2020 and 8/8/2022. Participants with nonmetastatic breast, colorectal, endometrial, and ovarian cancer (all stages) experiencing grade 2-3 CIPN (duration ≤ 2 years) were enrolled after completing taxane or platin-based chemotherapy. They were randomized into active and placebo groups, and followed x 16 weeks. The active group received 135 mg/day of CBD, provided as hemp-based whole plant extract in gelcaps, while placebo consisted of coconut oil gelcaps, delivered x 12 weeks. Participants were evaluated every 2 weeks using the EORTC QLQ-CIPN20, which assesses three categories of symptoms: sensory (numbness, tingling, pain), motor (weakness, difficulty walking), and autonomic (blurriness, hearing loss). Side effect and safety data were logged daily. Results: Of 230 participants with CIPN identified, 124 met eligibility, 54 consented and enrolled, and 46 completed ≥8 of the 12-week treatment phase and were included in the analysis. Mean age was 59.6 years; 89.1% were female. Of those participants, 63% had breast cancer, 19.6% colorectal, 15.2% ovarian, and 2.2% uterine. CIPN20 scores were summated and standardized. With placebo as the reference group, main effects for sensory and motor scales were adjusted for time from enrollment and baseline CIPN grade. Participants receiving CBD had greater improvement of sensory function (p=0.048), with reduced numbness and tingling, but without significant pain reduction (p=.282) or change in motor function (p=.158) vs placebo. No autonomic changes were observed. CBD was well tolerated without serious adverse events. Conclusions: CBD reduced numbness/tingling and improved sensory function vs. placebo, as assessed by the CIPN20 scale. These symptoms are among the most common and challenging symptoms of CIPN, for which there are limited available treatment options. However, CBD did not affect pain and motor function. Thus, this preliminary study provides evidence that CBD, dosed at 135 mg/day, might serve as a treatment for some CIPN symptoms without serious adverse events. Further research is needed to confirm these results and to assess the safety and efficacy of CBD combined with chemotherapy to prevent or attenuate CIPN. Such an advance could deliver a survival benefit by helping more people complete and better tolerate chemotherapy. Clinical trial information: NCT04398446 . [Table: see text]


Purpose – This paper aims to argue that the relationship between employer and employee needs to change from independent/dependent to interdependent.Design/methodology/approach – The paper puts forward the view that most management training does not work because it does not change behavior. The paper offers a model of training to help people and organizations to evolve.Findings – The paper describes what is missing in the employee contract – accountability on both sides. It explains what accountability means, why it is critical and how to start creating this in your organization.Practical implications – The paper argues that, if you want to have a successful employee‐engagement program, you have to start with employees who are engaged in their own life. Helping to grow people's self‐awareness and personal accountability is a good place to start. In this model of development, self‐awareness is defined as having a strong sense of yourself and the part you play in your world. It is the ability to respond in a...


The final set of challenges in The NASA Tournament Lab, ISS Challenge Series were focused on the humanoid robot currently aboard the Space Station known as Robonaut 2. The first phase of the competition was to develop a "seeing" algorithm. Contestants were asked to enable Robonaut 2 to recognize the state and location of several buttons and swit


Ives[3] compares three algorithms for generating LALR(1) lookahead sets. These algorithms will be referred to here as algorithm II which appeared for the first time in that paper, algorithm DP from DeRemer and Pennello[2], and algorithm PCC from Park Choe and Chang[5]. The conclusion in that paper was that II performs slightly better than PCC and that both perform significantly better than DP, which for a long time was the best algorithm for generating LALR(1) lookahead sets. Park and Choe[6]questions the conclusions concerning the relative performance of algorithms PCC and II. This article is a response to the observations made by Park and Choe. In addition, a new algorithm is described which is significantly better than algorithms PCC and Ii. One of the purposes of Ives[3] was to present the LALR(1) lookahead set generation algorithms in a common form so that the similarities between them could be easily observed. As pointed out there and in Park and Choe[6], when algorithms PCC and II are viewed in a common representation it is apparent that they differ primarily in how they partition the lookahead set definition. The originally published form of the Park Choe Chang algorithm was developed by recasting the DeRemer Pennello algorithm in the formalism introduced by Park Choe and Chang[5] and then modifying it to deal only with kernel items. It is reasonable that the partitioning of the lookahead set definition represented by algorithm PCC produces intermediate sets corresponding to the Follow sets of DeRemer and Pennello[2] limited to kernel items. Algorithm Ii was developed starting from an implementation of the textbook algorithm of Aho and Ullman[l], which limits set definition to kernel items. This algorithm was used until reading DeRemer and Pennello[2], and then modified to associate propagate sets with nonterminals instead of items and to use their Digraph algorithm for collecting the intermediate sets. The state independent Path sets, defined by Park Choe and Chang[5], simplified computation of the initial sets. It is reasonable that the partitioning of the lookahead set definition represented by algorithm II produces intermediate sets corresponding to the "propagated lookaheads" of Aho and Ullman[l]. The initial Propagate and Lookahead sets correspond to their "spontaneously generated" lookaheads, As it turns out, there are many fewer Propagate sets, as defined for algorithm II than there are Follow sets as defined for algorithm PCC. This represents a saving in space and a saving in set related …


Transportation system gets paralyzed when a place affected by any catastrophic natural disaster. Some roads get blocked and vehicle density increases in all the other remaining routes. Each vehicle stuck at different position of the road network and tries to reach its destination in minimum time. A cooperative game theory based approach is proposed to regulate road traffic and minimize the waiting time of individual vehicles in any disaster situation. Each vehicle acts as a player and tries to increase its payoff value. Payoff value is based on the different parameters of the vehicle like its arrival time, velocity, priority and traffic density. Payoff value is adjusted according to the existing vehicle density in the road segment. Traffic density of each road is minimized simultaneously which increases the flow of the vehicles in the network cooperatively. Waiting time of a vehicle is directly proportional to the number of adjacent edges of the corresponding node and its density. The method also shows that any vehicle with higher priority will cross the road in minimum time. New alternative road creation process is also proposed based on graph theory for the worst situation. The alternative path will join the affected road with a minimum utilized node in the network to evacuate the affected traffic. Experimental results suggest that our proposed method achieve minimum average waiting time compare to the existing method. The shortest time travel path is found for each vehicle from its source to the desired destination in post disaster situation.


Rapid growth in the information and communication technology has increased the demand for equipment in data centers. However, this is not followed by the expansion of space. The increase in high density data center equipment gives impact to the increase heat dissipation.
Cooling system in a data center consumes the highest power utilization after the IT equipment. The optimization of performance of the cooling system will give significant
benefit for energy efficiency. The objective of the study is to show the importance of numerical simulation in order to find the optimum arrangement of racks in data centers.
Optimization could be achieved by the arrangement of racks position and improvement in the cooling system and airflow management. Models and simulation of Computational
Fluid Dynamics (CFD) are developed for the room and equipment of data center where theeffect to temperature profiles will be observed. A case study of data center design in Kuala Lumpur with 30 racks of equipment and combination of raised floor cooling and spot
cooling was carried out. Results of CFD simulation show the problems arose in data center cooling and improvement was suggested to improve the distribution of cooling and
reduction of hot spots.


With the surge in environmental concerns all over the world, in particular global warming and air pollution which are partly caused by automobile transportation, the issue of a clean car is today clearly on the top of the agenda. The media are disseminating the feeling that the hybrid technology is an obvious answer to such problems. They are supported also by politicians and businesses needing to advertise their environment friendly policies and strategies. In the United States, which never signed the Kyoto protocol, General Motors, Ford and Chrysler are pressing President Bush to actively support a "national" technology and therefore a "national" industry for hybrids . The 2008 federal budget includes $42 million to accelerate research on advanced battery technologies for hybrids. New York mayor, Michael Bloomberg, promised that all 13 000 "yellow cabs" will be hybrid by 2012 from only 375 today ! IKEA decided all its fleet will be "hybridized" by 2010 in the United Kingdom.


This study aims to reveals the influence of Knowledge Management training on the performance of PT. Semen Indonesia (Persero) Tbk. The hypothesis proposed is (1) there are differences in employee performance after training between the experimental group and the control group, (2) there are differences in employee performance in the experimental group between before Knowledge Management training and after Knowledge Management training, (3) there are differences in Gain Score of employee performance in the experimental group before training with employee performance after training. The subjects in this study are leaders or employees who will become Knowledge Management agents or leaders who manage Knowledge Management in the work units of PT Semen Indonesia. Data collection methods used in this study use employee performance scale, observation and interviews. The data analysis technique used is Sample T-Test to see the differences in employee performance before and after training. The results showed that there were differences in employee performance before and after training with a value of t = 3.658 and significance of 0.001 (p <0.05). Keywords—Knowledge Management Training, Performance, Employee


Three pairs of Y chromosome specific primers for different gene in cattle were designed and applied to check genomic DNA of cattle,yak,sheep,goat,pig,mouse respectively.The amplification results of all three pairs of primers were obtained from genomic DNA of cattle and yak,only one amplification results of sex determine gene was obtained from sheep genomic DNA,and no amplification result was checked in the other species.After all the amplification products were cloned and sequenced,the sequences were blast with DNAMAN between cattle and yak or sheep.The identities of three sequences are more than 99% between cattle and yak,the identity of segment of sex determination gene is 94% between cattle and sheep.


Purpose To demonstrate in vitro the potential use of FDA-approved PLGA poly(lactic-co-glycolic acid) microparticles to aid visualisation of vitreous during anterior vitrectomy following posterior capsule rupture and to compare with the use of triamcinolone suspension.

Methods 10-60um sized PLGA microparticles were fabricated using the single and/or double emulsion technique(s) and used i) untreated (ii) pre-treatment with sodium hydroxide (iii) surface adsorption of a protein/synthetic peptide. Particle size, shape, morphology and surface topography were also assessed using scanning electron microscopy (SEM). The efficacy of these microparticles to enhance visualisation of vitreous against triamcinolone suspension was assessed using a simple in vitro set-up exploiting human cadaveric vitreous.

Results Unmodified PLGA displayed a degree of hydrophobicity and also a high rate of dispersion following repeated wash cycles. Interestingly, surface modified PLGA microparticles demonstrated a significant improvement in its 'vitreophilic' properties and were comparable to a triamcinolone suspension.

Conclusion The use of modified biodegradable PLGA microparticles may represent a novel method of visualising vitreous and aiding anterior vitrectomy. This method may provide a distinct alternative for the visualisation of vitreous without the pharmacological effects of triamcinolone. Furthermore, such a technique allows the incorporation of drugs, growth factors and/or antibiotics within the microparticles which may be desirable in complicated cataract extraction. Animal models are required to assess in vivo biocompatibility of this method.


A review of The World of Marine Mammals , by Adrienne Mason; A Seal in the Family , by Maria Coffey; Elisha the Flamingo and Her Amazing Adventures , by Dan and Jean Mayo.


The purpose of this study is to analyze the progress in convention and meeting research to date. To achieve the goal, the study conducted content analysis on published articles in KCI index. A total of 320 convention and meeting articles published in journals from 2006 to 2015 were collected. Content-analysis was conducted based on research areas, research design, and statistical technique. As results, this study identified five research areas: management strategy, operation, marketing, human resource management, finance and accounting, research development, and economy. With regard of research method, the study found that quantitative research method is predominant in convention research. Interestingly, more qualitative research method was found in the area of economy and finance and accounting. Discussion issues and suggestions for future research in the field of convention and meeting management are proposed.


The sanitary inspection in the fresh meat market shout be fast and accrute.This essay introduees several kinds of inspectional techniques which is available,fast and accrute,and which concluds the methods of abtaining the biochemistry index,bactarid endotoxin and determination of the meat which is injected with water.


A second-order turbulence closure for the new rough wall layer modeling using the Brinkman equation is developed to improve the predictive capability of a previously developed k-e turbulence closure for the new flow physics-based surface roughness model in rough wall turbulent boundary layers. In the proposed approach, the fluid dynamics of the volume-averaged flow in the near-wall rough layer is modeled by using the Brinkman equation. The porosity can be calculated based on the volumetric characteristics of the roughness and the permeability is modeled. A new interface stress jump condition including the Reynolds stress components are also developed for a second-order turbulence closure. The Reynolds-averaged Navier-Stokes equations are solved numerically above the near-wall rough layer, while a second-order turbulence closure is employed in all regions. The computational results, including the skin friction coefficient, the log-law mean velocity, the roughness function, the Reynolds stresses, and the turbulent kinetic energy, are presented. The results show that the new rough wall layer modeling approach with a second-order closure predicts well the skin friction coefficient, the log-law mean velocity, the roughness function, and the Reynolds shear stress.


ABSTRACT An education reform policy and inclusive education policy have been implemented in Hong Kong for over a decade. As more students with special educational needs have entered the mainstream education system under these policies, Hong Kong's primary music classrooms offer a site where three policies interact—the education reform policy entitled "Learning to Learn," the policy of inclusive education, and the undeclared "policy" of making savings in the government budget. This article seeks to explore the results of the interaction of these three policies. A qualitative study was carried out to investigate the views of Hong Kong primary school music teachers on the policy of inclusion in relation to music teaching. Insufficient support in inclusive learning in "non-core" subjects, such as music, is evidenced.


From the thirties "sinarquismo" became an important sociopolitic and socioideological strength in contrast with the Mexican posrevolutionary political system. This article makes an attempts to give and answer to some questions : what was the "sinarquismo" origin and development? Under what bases did it take root socially, politically and ideologically speaking?. How was "sinarquismo" linked to the global context of conservative, catholic and right-winger movements? And what was the story of the "sinarquista" movement in the middle occident of Mexico?.


Springs are essential mechanical elements that are used across a wide variety of industries and mechanisms. Common across many spring types and applications is the importance of compactness, low mass and customizability. In this paper, we present a novel rotary spring design that is lightweight, compact and customizable. In addition, we empirically validate the design by experimentally quantifying the performance of two test springs on a custom dynamometry testbed. Our two-part spring geometry is comprised of a central rotating gear-like cam shaft, and a disk that includes a circular array of radially-spaced tapered cantilevered beams. The two springs that we designed and tested matched desired performance specifications within 3–6%, confirming the efficacy of this unique design approach.


This paper presents implementation structure of an arbitrary waveform generator (AWG) using direct RF synthesis in FPGA, which is used to interpolate baseband data to RF sample rate and modulate it with generated RF quadrature carrier. The modulated data can be converted to wideband tuning and very fast frequency switching arbitrary waveform by DAC.


Abstract In this study, we consider the asymptotic value of the ratio of good-to-bad Gram points for the Riemann zeta function. We present two new results. The first is a relation between the ratio of good-to-bad Gram points and the distribution of Gram intervals that contain a given number of zeros. We relate this to a conjecture of Odlyzko about the locations of the zeros of the Riemann zeta function. The second is the formulation and experimental validation of two symmetry-related conjectures about the location of the zeros.


The diffusion of Be in GaAs is studied in samples which are molecular beam epitaxy GaAs with grown‐in Be. The Be diffusion profiles of samples annealed under various conditions are obtained using secondary ion mass spectrometry. SUPREM‐IV.GS, a simulator for GaAs and Si processing technology, is used to compare the experimental results with our models and to extract parameters. The Be diffusion profiles show a kink feature and a time‐dependent Be diffusivity which are successfully simulated. The intrinsic Be diffusivity, the Ga interstitial diffusivity, and the equilibrium concentration of Ga interstitials, all as a function of temperature, are obtained from this study: D+1Be=0.17 exp(−3.39 eV/kBT) cm2 s−1, DI=6.4×10−5 exp(−1.28 eV/kBT) cm2 s−1, and CI*int=4.7×1028 exp(−3.25 eV/kBT) cm−3. The role of nonequilibrium Ga point defects in the anomalous Be diffusion behavior is addressed.


We experimentally analyze how to design preopening mechanisms facilitating coordination on high equilibrium liquidity and gains from trade. We allow a call auction to be preceded by a preopening or not, preopening orders to be binding or not, and the opening time to be deterministic or random. When the preopening is nonbinding, traders place manipulative orders, reducing the credibility of preplay communication. Random market opening deters manipulation, but also hinders communication by making it costly. Gains from trade are maximized when preopening orders are binding. This enables some traders to place early limit orders, attracting further liquidity.

Data, as supplemental material, are available at http://dx.doi.org/10.1287/mnsc.2013.1787 .

This paper was accepted by Wei Xiong, finance.


A new detecting system of low responsibility detector surface respond is introduced,the testing principle of detector surface respond detecting by laser modulation is given.Modulation 650 nm laser is the radiation resource of this equipment,the constitution in machinery and electric of this testing as well as it's working principle and technical feature are introduced.The control flow and the software design are discussed.Experiments show that this scheme based on modulated laser is effective.


Drought severely limits crop yield of peanut. Yet cultivars with enhanced root development enable the exploration of a greater volume of soil for water and nutrients, helping the plant survive. Root distribution patterns of three genotypes (ICGV 98305, ICGV 98324 and Tifton-8) were compared when grown in well-watered rhizoboxes and when grown in rhizoboxes where an early-season drought was imposed using rain-exclusion shelters. The treatments were arranged in a completely randomized design with three replications, and the experiment was conducted during two seasons at the Field Crop Research Station of Khon Kaen University, in Khon Kaen, Thailand. The root system of ICGV 98305, when grown under drought, had a significantly higher root length in the 30–110 cm deep soil layers and less roots in the 0–30 cm soil layers when under drought than when grown under well-watered conditions. Roots of Tifton-8 had the largest reductions in root length in upper soil layer and reduced in most soil layers. Tifton-8 grown under drought was smaller than under well-watered control for all root traits, showing negative response to drought. The peanut genotypes with high root traits in deeper soil layer under early-season drought might contribute to drought avoidance mechanism.


Context  A new student selection instrument has been designed to assess candidate suitability for a problem‐based learning, small group curriculum.


The cognition of parents and teachers regarding " difficult-to-raise " children are important in the development of children. Differences between parents and teachers in this respect may have a negative impact on children's development. The aim of this study is to examine the current status of the cognition of parents and teachers on child-raising anxiety and compare the results between parents and a teacher. Parents and a teacher of children attending a preschool learning center participated in the study. A questionnaire survey was conducted among parents concerning their child-raising anxieties. The percentages of children regarding whom the parents felt child-raising anxiety ranged from 3.3% to 13.3%, while the corresponding percentages for the teacher ranged from 0% to 7.5%. Three different factors were related to child-raising anxiety in the parents: the Kaup index, whether or not the child was the first child, and the place of delivery. In conclusion, there were some differences in the child-raising anxieties. The Kaup index, whether the child is the first child or not, and the place of delivery might affect the cognition of parents regarding whether they felt the child was difficult to raise.


Design of time sequence driving circuit is the key technology for applications of CCD.Driving schedules of TH7834C(one kind of long linear CCD produced by ATMEL Co Ltd)are examined.The time sequence driving circuit is designed for TH7834C.Field Programmable Gate Array(FPGA)is chosen as the hardware design platform,the time sequence driving circuit is described with VHDL.The design is successfully fulfills function simulation with EDA software and fits into EPF10K30RC240-3(a kind of FPGA products made by Altera Corporation).The result of the project realization indicates that the time sequence driving circuit is suitable for the driving of TH7834C,and the design is characterized by simple framework,low power consumption,strong anti-jamming ability,higher of practical value.The result can be proposed as a skill applied to CCD components of various models as well.


The bulk viscosity of neutron star cores containing hyperons is studied taking into account non-equilibrium weak process $\rm n+n \rightleftharpoons p+\Sigma^-$. The rapid growth of the bulk viscosity within the neutron star core associated with switching on new reactions (modified Urca process, direct Urca process, hyperon reactions) is analyzed. The suppression of the bulk viscosity by superfluidity of baryons is considered and found out to be very important.


Carl Schmitt is, undoubtedly, one of the authors who more has influenced the political theory in Spain. The aim of this study is to clarify in what measure he influenced the figure of one of the biggest conservative thinkers of the second half of the 20th century in Spain, Gonzalo Fernandez de la Mora. The theory of History, the conception of the political and the projection of his theory in the international relations shape the three axes of this comparison. From this perspective there appear points of contact and of difference and it will be verified how, assuming partially the schmittian categories, Fernandez de la Mora's thought turns out to be, in a sense, an answer to the work of the German author. From the perspective of the Plettenberg's jurist Fernandez de la Mora's thought might be qualified of «liberal».


Background: Patients with inflammatory bowel disease (IBD) carry a 2-4 fold higher risk of venous thromboembolism (VTE) than persons in the general population. Most VTE present as deep vein thrombosis (DVT) of the lower extremity or as pulmonary emboli (PE), but they can also occur in other locations, including mesenteric and cerebral sinus thrombosis. Such atypical VTE may evade detection until the development of serious complications. Aims: We describe 2 unusual presentations of VTE associated with serious sequalae at our centre and review the literature of VTE in IBD. Methods: We retrospectively reviewed 2 atypical cases of VTE in IBD patients admitted to The Ottawa Hospital in June 2018. We also conducted a Pubmed search to review the literature regarding the incidence and varied manifestations of VTE in persons with IBD. Results: A 21-year old male with a history of ulcerative colitis presented with typical symptoms of a colitis flare with pain and diarrhea along with severe unremitting abdominal pain. A flexible sigmoidoscopy showed severe ulcerative colitis and an area of ischemic colitis in the sigmoid colon. Symptoms did not improve with IV steroids and a CT scan was done showing extensive abdominal mesenteric venous thrombosis that was treated with systemic anticoagulation and close monitoring.


The method of determining trace chromium in soil by using potassium permanganate oxidation,iodine-starch-spectrophotometric is tested and researched into.Sample shall be dissolved,with the KMnO_4 oxidation Cr(Ⅲ)to Cr(Ⅵ),Used the NH_4HF_2 masking Fe~(3+),and keep the pH is 3.0~4.0.Iodine and starch form a blue complex.Then with sepectrophotometer determination its absorbance in(λmax)=590 nm.The relative standard deviation is3%,the recovery rate of chromium is between 93.4%~103.0%.The improved method proved to be simple,accurate,quick and operate is easy.


RT-PCR was established to detect Narcissus latent virus(NLV)using a pair of specific primers which were designed and synthesized based on the published nucleotide sequence of NLV.The cDNA was synthesized from the total RNA prepared from narcissus sample and then PCR was carried out.The expected 829-bp product was amplified from the NLV-infected narcissus sample.The results showed that RT-PCR method had good specificity and high sensitivity.It could be concluded that the method could be effectively applied to the detection of NLV in narcissus samples.


Today's politics in Europe strongly encourages sustainable development within companies. Hence, it is important to raise awareness in rational use of the utilities, such as electrical energy or spa ...


Severe influenza infections are featured by acute lung injury, a syndrome of pulmonary microvascular leak. A growing number of evidences have shown that the pulmonary microvascular endothelial cells (PMVEC) are critical target of influenza virus, promoting microvascular leak. It is reported that there are multiple mechanisms by which influenza virus could elicit increased pulmonary endothelial permeability, in both direct and indirect manners. Ezrin/radixin/moesin family proteins, the linkers between plasma membrane and actin cytoskeleton, have been reported to be involved in cell adhesion, motility and may modulate endothelial permeability. Studies have also shown that ERM is phosphorylated in response to various stimuli via p38MAPK, Rho/ROCK or PKC pathways. However, it is unclear that whether influenza infection could induce ERM phosphorylation and its relocalization. In the present study, we have found that there are cytoskeletal reorganization and permeability increases in the course of influenza virus infection, accompanied by upregulated levels of p-ERM. p-ERM's aggregation along the periphery of PMVEC upon influenza virus infection was detected via confocal microscopy. Furthermore, we sought to determine the role of p38MAPK, Rho/ROCK and PKC pathways in ERM phosphorylation as well as their involvement in influenza virus-induced endothelial malfunction. The activation of p38MAPK, Rho/ROCK and PKC pathways upon influenza virus stimulation were observed, as evidenced by the evaluation of phosphorylated p38 (p-p38), phosphorylated MKK (p-MKK) in p38MAPK pathway, ROCK1 in Rho/ROCK pathway and phosphorylated PKC (p-PKC) in PKC pathway. We also showed that virus-induced ERM phosphorylation was reduced by using p38MAPK inhibitor, SB203580 (20 M), Rho/ROCK inhibitor, Y27632 (20 M), PKC inhibitor, LY317615 (10 M). Additionally, influenza virus-induced F-actin reorganization and hyperpermeability were attenuated by pretreatment with SB203580, Y27632 and LY317615. Taken together, we provide the first evidence that p38MAPK, Rho/ROCK and PKC are involved in influenzainduced cytoskeletal changes and permeability increases in PMVEC via phosphorylating ERM. © 2014 Elsevier B.V. All rights reserved.


The identification of the individual arose from the discovery of a document in the\r\nRegister House, Edinburgh which was signed by " Alexander Monro of Auchinbowie and\r\nCaptain George Monro of Brigadier Otway's Regiment of Foot, his brother-german." It is known that Otway's Regiment, the 35th Foot, now the Royal Sussex, formed the nucleus of the garrison at Fort William Henry, and Captain Monro's record of service in the manuscript Army List for 1752 shows that he is the Colonel Monro who was given the command of the regiment in 1750. An account of his life is presented along with a description of the fighting which is one of the best known incidents in American history.