Abstract Agitation is a challenging dementia-related behavioral symptom and disconcertingly leads to an undesirable increase in pharmaceutical intervention. Agitation is primarily assessed subjectively by time-impoverished caregivers or clinicians, who may not be able to provide comprehensive or sensitive enough reporting to detect early signs of agitation or identify its precipitants. The purpose of the MODERATE (Monitoring Dementia Related Agitation Using Technology Evaluation) study is to characterize dementia-related agitation and its potential catalysts using wearables and sensors installed in participants' private living quarters within memory care (skilled nursing) facilities. Preliminary data from seven episodes of agitation–reported by nursing staff and treated by pharmaceutical intervention–were captured and characterized with an integrated network consisting of research-grade actigraphy, passive infrared presence sensors, door contact sensors, ambient environmental sensor boards, and bed sensor mats. Behaviors (e.g. pacing, space transitions) during 8-hour nursing shifts that included episodes of agitation were compared with 8-hour nursing shifts without any episodes of agitation. The environmental conditions (temperature, lighting, humidity, and decibel level) during agitated periods and non-agitated periods were also compared. There was a statistically significant difference between agitated periods and non-agitated periods for the number of space transitions in the living room (p<0.01) and for the measured amount of ambient light and humidity (p <0.05). Passive monitoring of behavioral activity is a promising method of unobtrusive, early, and objective detection of dementia-related agitation, expanding the window of opportunity for identifying factors associated with behavioral change and delivering appropriate evidence-based interventions.


They will make some comments whenever we talk about the class line, but they deserve that! (Applause) Speaking of class line, we are "people with vested interest."


Umberto Cerroni: Democracy, Socialism and Law ABSTRACT: The author commemorates the philosopher of law Umberto Cerroni, who passed away recently. Cerroni was the first scholar to devote critical attention to the relationship between Marx and law. Numerous studies about the injustices inherent in bourgeois law had been published in the tradition of academic socialism, but no author before Cerroni had ever taken a philologically rigorous stance to tackle Marx's legal thinking. Cerroni analysed Marx's critique of Hegel's philosophy of public law and then the legal thinking of communism in practice. Cerroni also deserves to be remembered for his analysis of democracy in the formation of modern society. This scholar saw democratic participation, universal suffrage and the equal distribution of political rights as a precondition for modernity and social development.


As an important branch in the field of computer vision, object tracking has been widely used in many fields such as intelligent video surveillance, human-computer interaction and autonomous driving. Although object tracking has imposing development in recent years, tracking in the complex environment is still a challenge. Due to problems such as occlusion, object deformation, and illumination change, tracking performance will be inaccurate and unstable. In this paper, an object tracking algorithm for Siamese network combined with channel attention mechanism is proposed. Firstly, the Siamese network is used to improve the ability to discriminate features; secondly, the channel attention mechanism is introduced to design a cross correlation module DCAM (Depth-wise Cross-correlation with Attention Mechanism, DCAM), which pays more attention to the features that are beneficial to the tracking results; finally, the stochastic weight averaging method is used to train the network to further improve the overall performance of the tracker. Experimental results on public data sets show that the proposed algorithm has higher accuracy and more stable tracking performance in complex tracking environment


Mapping functional zones for rural landscapes is the foundational work for rural land use planning and plays a very important role in the economic development and resource management utilization of rural areas. However, the traditional manual delineation of functional zone boundaries empirically in rural areas is labor-intensive, time-consuming, and lacks the consideration of spatial landscape patterns. The emergence of high-resolution remote sensing imagery and image segmentation has facilitated the analysis of ground landscape information and patterns, but there is still a lack of functional zone boundary mapping methods applicable to rural landscapes. To address this, we propose a functional zoning method called multiscale merging of landscape contextual and shape characteristics with heterogeneity indices (M2LHI) for mapping geographic boundaries for rural landscapes based on high-resolution remote sensing imagery. The landscape contextual features were first constructed based on the geospatial distances of landscape types, and then, the dominance index and shape index were introduced to quantify the landscape heterogeneity by object-oriented image analysis. Then, the automated merging of adjacent landscape units based on the thresholds of the landscape heterogeneity indices was performed to map the initial zones. The final rural functional zones were defined based on the main function in the zone. The study was carried out in three typical rural landscapes (hilly countryside, flat countryside, and grassland countryside) located in Fujian, Xinjiang, and Inner Mongolia, China, and the freely available Gaofen-2 (GF-2) satellite imagery was used as the data source. We compared the boundaries of mapped functional zones and reference functional zones, and the matching and inclusion ratios of the final functional zones mapped in each case were bigger than 78%, indicating that the M2LHI method has a high ability to map the functional spatial patterns. The overall accuracies of mapping functional zones with different functions were 95.9%, 89.0%, and 92.1% for the respective cases. The results demonstrated that the M2LHI method effectively quantifies landscape heterogeneity and accurately delineates functional zones with different landscape patterns. It can provide a scientific basis for rural planning and management and efficiently draw reasonable geographic boundaries for rural functional zones.


The building energy management systems its control and automation in buildings has significant role. These systems can play an important role in regular energy monitoring and management and therefore to save the possible energy and cost. The key point of the building automation market is focused upon better facilitation to the user in terms of comfort at reduced operation cost. Energy efficiency improvement will also contribute to environmental protection. Therefore there have been regulations and rating systems made that mandates the requirement of energy monitoring and control in a building. For example, the above mentioned building utilities and equipment control and automation plays an integral role in achieving the green building rating points from certifying authorities such as GRIHA and IGBC. The proposed system is to control the active systems such as lighting including artificial lighting (on/off & dimming control), air conditioners and safety features like fire alarm & gas alarm. In future the existing idea can be implemented for the whole building, i.e. various rooms or areas and then all of them can be integrated on a common platform for monitoring and control of different equipment.


Objective : The article evaluates cooperation in enterprises from the point of view of building creative capital. Research Design & Methods : Research was conducted among companies from Poland's Podkarpackie Province: 100 entities from the creative sector and 430 entities operating in various sections of the national job-type classification. Findings : There is a need to create mechanisms conducive to establishing and strengthening cooperation in creativity. The survey on cooperation done among respondents in enterprises revealed that their average assessment was of "a medium impact". Implications / Recommendations : The dimension of cooperation does not differentiate enterprises conducting different economic activities in terms of how they build creative capital. Contribution : the novel aspect of this research was its combination of issues of cooperation and creative capital. Cooperation was accepted as a component of creative capital and assessed according to the author's formula. The comparative assessment made among creative sector enterprises and other sections of the national job-type classification can be considered as input.


Generative Adversarial Networks (GANs) based semi-supervised learning (SSL) approaches are shown to improve classification performance by utilizing a large number of unlabeled samples in conjunction with limited labeled samples. However, their performance still lags behind the state-of-the-art non-GAN based SSL approaches. We identify that the main reason for this is the lack of consistency in class probability predictions on the same image under local perturbations. Following the general literature, we address this issue via label consistency regularization, which enforces the class probability predictions for an input image to be unchanged under various semantic-preserving perturbations. In this work, we introduce consistency regularization into the vanilla semi-GAN to address this critical limitation. In particular, we present a new composite consistency regularization method which, in spirit, leverages both local consistency and interpolation consistency. We demonstrate the efficacy of our approach on two SSL image classification benchmark datasets, SVHN and CIFAR-10. Our experiments show that this new composite consistency regularization based semi-GAN significantly improves its performance and achieves new state-of-the-art performance among GAN-based SSL approaches.


The probability of plunging orbits is enhanced in groups of galaxies and indeed, observations show that ring galaxies, which are believed to form when a galaxy passes through the center of a larger rotating disk, are often found in small groups. Numerical simulations combined with a knowledge of the large-scale HI distribution provide strong constraints on the dynamical history of these systems and on the identity of the intruder. Here we present a numerical model of the Cartwheel which supports the suggestion that the most distant companion is the intruder. We also present high-resolution HI observations of the more irregular system Arp 119 that reveal a possible connection to the most distant companion.


The utility model relates to a full covered reflection type high-power completely even light collecting photovoltaic power generating device, solving the technical problems of low even light collecting efficiency, high cost, complex structure and unstable output voltage of the existing solar power generating device; the device comprises a photovoltaic battery component, a reflector component and a support component; wherein the support component comprises a solar tracking device; the photovoltaic battery component comprises a battery bracket and a rectangular photovoltaic battery component which is arranged at the upper end of the battery bracket; and the reflector component comprises four reflector units which are symmetrically arranged at the outer periphery of the lower end of the battery bracket. The whole surface of the photovoltaic battery has even light interception. The device has the advantages of light collecting efficiency, low cost, simple structure, low energy consumption and pollution and easy cleaning.


Since there has been growing concern about the damage that atmospheric leakage and dispersion accidents may have done to human beings, researchers are dedicated to study effective and feasible source estimation methods in chemical plant clusters. In this paper, the safety monitoring of chemical production process is conducted via an unmanned aerial vehicle (UAV) monitoring system. Based on the observed data from this system, a source estimation method incorporating Bayesian inference and Particle Swarm Optimization (PSO) is proposed. Furthermore, the method is extended to discuss the source tracing algorithm using game theory in the UAV system. Finally, a practical case study is carried out to verify the feasibility and credibility of the proposed method. Results show that the method and system are helpful for safety monitoring and risk assessment in a chemical plant cluster.


1:Understanding Cancer Cancer Survivorship Epidemiology of Cancer Prostate Cancer The Gynecologic Cancers Hematologic Cancers Skin Cancer Cancer Surgery Chemotherapy Administration Principles of Radiation Therapy Principles of Biotherapy and Gene Therapy 2:Helping your Patients with their Cancer Experience Sexuality, Body Image, and Cancer Venous Access Devices Nausea and Vomiting Mucositis in Cancer Patients Anorexia Constipation and Diarrhea Pain Assessment and Management in People with Cancer Mood Alterations Fatigue Myelosuppresion Complementary and Alternative Therapies for Cancer Dying Spirituality 3:Issues of Today and Tomorrow Changes in Cancer Care Reimbursement Ethical Dimensions in Cancer Care The Challenges of Cultural Diversity in Patient Care Inde


An outsourcing company with a work contract period can run well if the work agreement made by the client is carried out properly. One of the things that affect the contract period is client complaints. By minimizing client complaints, the sustainability of work contracts between outsourcing companies and client companies is getting higher. For this reason, outsourcing companies assign workers based on the abilities of each worker so that the work results are optimal. One of the methods in solving assignment problems is the Hungarian method and the QM application. The purpose of this research is to minimize the value of hygiene complaints from clients. The results showed a reduction in the value of 15 client complaints from 43 complaints to 28 complaints related to the completion of the assignment of employees of outsourcing company using the Hungarian method and the QM application.


Objective To observe the effect of Insulin( INS) combined with Ethyl Pyruvate( EP) in treatment of multiorgan dysfunction syndrome( MODS) rats with inflammatory response and oxidative stress after severe burns.Methods A total of 80 MODS rats with degree III burns over 30% of body surface area were randomly divided into INS treatment group( n = 20),EP treatment group( n = 20),INS + EP group( n = 20) and control group( n = 20). The INS,EP,INS + EP and control groups were respectively given peritoneal injection with INS [2. 0 U /( kg · d) ],EP[40 mg/( kg·d) ],INS + EP[2. 0 U/( kg·d) + 40 mg/( kg·d) ]and same volume of Ringer Solution. The values of alanine transarninase( ALT),MB isoenzyme of creatine kinase( CK-MB),creatinine( Cr) of blood glucose and concentrations of tumor necrosis factor-α( TNF-α),high mobility group protein-1( HMGB1),malondialdehyde( MDA) and total anti-oxidant capability( TAC) of blood in all groups were detected and compared before the injury and on 1st,3rd,5thand 7thd after the injury. Results The levels of ALT,CK-MB and Cr of blood glucose,and TNF-α,HMGB1,and MDA levels of blood in INS,EP and INS + EP groups at different time points were significantly lower( P 0. 01),while TAC levels were significantly higher than those in the control group( P 0. 01). The levels of ALT,CK-MB and Cr of blood glucose,and TNF-α,HMGB1 and MDA of blood at different time points in INS + EP group after burns were significantly lower( P 0. 01),while the TAC levels were significantly higher than those in INS and EP groups( P 0. 01). The levels of blood glucose at different time points in INS + EP and INS groups after burns were significantly lower than those in EP group( P 0. 01). There were no significant differences in levels of blood glucose at different time points in INS + EP and INS groups after burns( P 0. 05). The levels of TNF-α,HMGB1 and TAC were significantly lower( P 0. 01),and the MDA levels were significantly higher at different time points in INS group after burns than those in EP group( P 0. 01). Conclusion Insulin and Ethyl Pyruvate can effectively weaken the inflammatory response and oxidative stress of MODS rats after severe burns. Both Insulin and Ethyl Pyruvate have their own advantages,and the effect of combination therapy is better than that of mono-therapy.


A new method in digital speckle pattern interferometry is in- troduced. It is a two-stage process. In the first stage, two states (un- loaded and loaded states) of the master object are recorded in a holo- graphic plate using the usual holographic arrangement. In the second stage, various phase stepping algorithms are applied, using the recon- structed wavefronts of the master object as a holographic optical ele- ment to produce reference wave fields in the comparison process. The method is investigated, and its viability is demonstrated by experimental results and computer simulations. © 1999 Society of Photo-Optical Instrumenta- tion Engineers. (S0091-3286(99)01507-X)


This paper maintains that the more and more prevailing tendency of affixatonization in contemporary Chinese has been effected under the influence of English, which is featured by its more and more remarkable affixationization tendency.This is an indication of Chinese culture′s positive acculturation in the intercultural communication between China and the West.


Introduction. Disposal of recycled materials is targeted at saving the natural resources and reducing the volume of wastes that have to be disposed of in special landfills. Disposal is encouraged by many countries of the European Union. A key element in promoting of wastes recycling is the «polluter pays» principle, which has been included in all Community directives regarding management of safe and hazardous wastes. In order to encourage recycling, many Member States have adopted specific environmental legislation, in particular, the wastes disposal tax.Problem statement. Today, in Ukraine the issue of utilization of industrial wastes has not been solved, that is why a considerable part of them are in the dumps and pose a great risk for the environment; and only a small part of them is utilized in the construction projects [1], although there exists the «State Target Economic Program for the Development of Public Roads of National Significance for 2018–2022» [2] and the Order of the Cabinet of Ministers of Ukraine [3] which regulate the use of local materials, including industrial waste during the construction of motor roads. At the same time, millions of tons of dusty wastes are being produced at the Ukrainian power plants as a result of coal combustion — fly ash and ash from a tailings dam.Purpose. Carrying out of research of ash from a tailings dam and a mixture of limestone material with the ash from the tailings dam on conformity with the requirements to fillers.Materials and methods. The ash from a tailings dam, a mixture of limestone material with the ash from a tailings dam and commercially produced limestone filler have been selected for the study.Results. The results of the research on establishing the possibility of using the dusty waste products from power generating plants for the production of asphalt mixtures are presented. Experimental studies have been performed to determine the physical and mechanical properties of the ash from the tailings dam with partial replacement by limestone material. The conformity of the studied materials to the requirements of national standards was determined.Conclusions. Studies for determination of grading, porosity, swelling and structuring ability showed that the tested ash does not meet the requirements of Table No.5 of DSTU B V.2.7-121 for porosity in the case of compaction of 40 MPa; a mixture 80:20 — for swelling of samples of the filler with bitumen; and the mixture 50:50 meets the established requirements by defined indicators. A significant swelling increase of the samples from the mixture of filler with bitumen may be the result of high content of clay impurities in the test materials.Keywords: industrial wastes, limestone material, ash, filler. physical and mechanical properties.


Blends of poly(L-lactide) (PLA), containing from 5, 15, or 25 wt % potato starch, unmodified or hydrophobized in methane plasma, were prepared and studied. To enhance the drawability of the blends, the plasticization of PLA with 10 wt % poly (ethylene glycol) (PEG) was also employed. The thermal and mechanical properties of the blends with amorphous and crystalline matrices were investigated. The hydrophobization of starch did not improve the ultimate properties of the blends, which were generally worse than those of neat PLA, because of the separation of the starch grains from the polymer matrix during tensile drawing. The separation also occurred in blends with a PEG-plasticized matrix containing 15 wt % modified starch, which fractured earlier than PLA plasticized with PEG. Nevertheless, the elongation at break of the plasticized blends reached 1.3, which was considerably more than that of blends with corresponding starch contents without a plasticizer (ca. 0.05). © 2007 Wiley Periodicals, Inc. J Appl Polym Sci 105: 269–277, 2007


Polymer bearings are widely used under certain environments due to the advantages on light weight, low friction coefficient, high corrosion resistance and electric insulation. The main reason for polymer bearing failures in water was formation of flakings due to crack propagation. However, the mechanism of fatigue crack propagation in polymer material under rolling contact condition has not been clearly explained yet. In the present study, detailed crack observations were made on cross sections along both radial and rolling directions after RCF (Rolling Contact Fatigue) test in water using PPS thrust bearings.


Gray Smith, Monique. You Hold Me Up. Illustrated by Danielle Daniel. Orca Book Publishers, 2017.
Monique Gray Smith is not a prolific author, but her works have impact. She writes from her knowledge of the impact of the Indian Residential Schools on Canadian Indigenous people. Gray Smith is a mixed-heritage woman (Cree, Lakota and Scottish) who wrote this book "to remind us of our common humanity and the importance of holding each other up with respect and dignity." "With this book," she says, "we are embarking on a journey of reconciliation and healing."
Gray Smith uses simple terms and sentences, appropriate to a Kindergarten to Grade 3 audience, to describe the things that individuals can do in their relationships to move forward in reconciliation. Danielle Daniel's brightly coloured, stylized illustrations reflect these concepts. The concepts include being kind to each other, sharing, learning, playing, laughing and singing together, and comforting, respecting and listening to each other.
The Truth and Reconciliation Commission calls all Canadians to move forward together in reconciliation, a task that can appear to be daunting and overwhelming. Gray Smith provides a simple blueprint for small steps forward, the most basic being that we can "hold each other up."
This book is highly recommended for elementary school libraries and public libraries.
Highly recommended: 4 out of 4 starsReviewer: Sandy Campbell
Sandy is a Health Sciences Librarian at the University of Alberta, who has written hundreds of book reviews across many disciplines. Sandy thinks that sharing books with children is one of the greatest gifts anyone can give.


The ion and fluidic transport in the nanopore system is investigated via a multi-physical modeling of the electrostatic, nanofluidic and ion motion properties. We solve a series of coupled equations including Poisson, Navier-Stokes and Nernst-Plank descriptions for the system. We quantitatively investigate the relation between the induced electroosmotic flow in the presence of nanopore wall surface charges and the applied cross-pore voltage. Such electrical-to-mechanical energy conversion may find potential application in nanoelectro-mechanical devices (NEMS).


Music streaming service has become more and more popular in recent years. However a huge amount of operation costs still distress service providers such as Spotify, KKbox, Pandora etc. Accordingly, it is important to attract users' continuous subscribing service. In this study, we develop and propose a conceptual research model in the context of music streaming service, using flow theory as a focal construct to examine its antecedents and the effect on users' intentions to continue subscribe service. The present study looks forward to contributing to the research on flow theory by proposing and testing the conceptual model. Hence, ultimately provide service provider guidelines to create optimal service experience of music streaming.


The impending no-reflow (NRF) state was studied in the rat hindlimb to identify possible biochemical mediators producing the no-reflow phenomenon. After 5 hours of ischemia, the venous effluents draining the ischemic limb and the contralateral nonischemic limb were collected for three 30-minute time periods. Thromboxane B2 (TxB2), prostaglandin E2 (PGE2), and 6-ketoprostaglandin F1α, the stable metabolite of prostacyclin (PGI2), were measured by radioimmunoassay. Venous outflow rate, distal skin perfusion assessed by dermofluorometry, and histology of muscle and skin were examined in control limbs, ischemic limbs, and limbs with impending no reflow. The no-reflow state was characterized by a significantly decreased venous outflow (<0.01 ml per minute), decreased skin perfusion (index of fluorescence of 15 percent in no-reflow limbs versus 70 percent in reflow limbs), and absence of thrombosis of the vasculature. The no-reflow state also was associated with 2.4 times more thromboxane B2 and 1.5 times more 6-ketoprostaglandin F1α than that observed in ischemic limbs with reflow. The biosynthesis of vasodilating prostaglandin E2 in the no-reflow state, however, was only 40 percent of the prostaglandin E2 measured in limbs with reflow. We propose that the impending no-reflow state may reflect a state of global microcirculatory "agona" vasoconstriction, most probably due to an overabundant release of the vasoconstrictor thromboxane relative to the vasodilating prostaglandin E2 and prostacyclin. The likelihood of specific biochemical mechanisms producing the no-reflow state suggests that pharmacologic agents may be able to reverse the impending no-reflow state to improve tissue survival.


The response to the penalty for an environmental violation on the firm level is a matter of reactive corporate environmental practices, about which the existence of a penalty is critical for environmental public policy. We propose that a penalty acts as a deterrence signal to enhance the perceived threat of legal punishment and the peer effect serves as the path through which peer firms learn from target firms. Based on the peer effect among firms and the deterrence effect in criminal economics, we investigated whether and how the peer firm responds to the penalty for environmental violation of target firms in the same industrial sector. Using samples of Chinese listed firms from 2008 to 2015, this paper finds that the penalty for the target firms can increase the peer firms' environmental investment, and compared to the sample with low-level environmental regulation, the increase in the sample with high-level environmental regulation is more significant. These findings suggest that a penalty for target firms has a deterrence effect on peer firms and the environmental regulation strengthens the above deterrence effect. This is expected to help both theorists and practitioners achieve a better understanding of the implementation of a penalty for an environmental violation.


Sediment phosphatases of a small first-order stream were investigated using 4-methylumbelliferyl phosphate. The degradation of organically bound phosphorus was inferred to involve an unidentified number of isozymes. Two pH-dependent isozyme groups could be identified, with activity optima occurring under acid (pH 5.0-6.0) and alkaline (pH 8.0-9.0) conditions. The multiphasic kinetic responses of the phosphatases varied markedly from sample to sample and were not correlated with the measured sediment substrate pools (organic matter, total phosphorus, soluble reactive phosphorus). The presence of multiple phosphatases implies that regulation of enzyme synthesis occurs in response to the competition for specific substrates.


We study the distributions of earthquake numbers in two global catalogs: Global Centroid-Moment Tensor and Preliminary Determinations of Epicenters. These distributions are required to develop the number test for forecasts of future seismic activity rate. A common assumption is that the numbers are described by the Poisson distribution. In contrast to the one-parameter Poisson distribution, the negative-binomial distribution (NBD) has two parameters. The second parameter characterizes the clustering or over-dispersion of a process. We investigate the dependence of parameters for both distributions on the catalog magnitude threshold and on temporal subdivision of catalog duration. We find that for most cases of interest the Poisson distribution can be rejected statistically at a high significance level in favor of the NBD. Therefore we investigate whether these distributions fit the observed distributions of seismicity. For this purpose we study upper statistical moments of earthquake numbers (skewness and kurtosis) and compare them to the theoretical values for both distributions. Empirical values for the skewness and the kurtosis increase for the smaller magnitude threshold and increase with even greater intensity for small temporal subdivision of catalogs. A calculation of the NBD skewness and kurtosis levels shows rapid increase of these upper moments levels. However, the observed catalog values of skewness and kurtosis are rising even faster. This means that for small time intervals the earthquake number distribution is even more heavy-tailed than the NBD predicts. Therefore for small time intervals we propose using empirical number distributions appropriately smoothed for testing forecasted earthquake numbers.


Modern Active Phased array Radar systems with a large number of T/R modules, multi-channel receiver down converters and distributed power distribution networks leads to design and analysis of the receive signal path more complex. In this paper receive signal path design of a typical 1000 T/R modules based fully distributed active phased array radar is discussed in detail including the gain, Spurious Free Dynamic Range (SFDR) requirements at different levels. The techniques for optimization of SFDR and system performance also described along with the Systemvue model to receive path calculations is presented.


Can adventure tourism as a niche sector boost a destination's number of customers? This book will review the potential for a destination to create awareness and to increase popularity through adventure tourism by the example of the Salzburger Sonnenterrasse St.Veit - Schwarzach, Austria. During the first chapters a general introduction into the topic of adventure tourism followed by trends in the adventure tourism sector and current adventure tourism offers at the Salzburger Sonnenterrasse St.Veit-Schwarzach will show the possibility for new product developments. Undertaking quantitative and qualitative research in the second part of this book will give a clear picture and will point out the potential to attract more people through new adventure tourism products. As it is vital for any destination to be a step ahead of others, these considerations will be highly important and decisive for the future decision making processes of any destination.


6-Butyl-5,6-dihydrobenzimidazo[2,1-a]isoquinoline, 3,9- and 3,10-dimethoxy, and 3,9- and 3,10-dihydroxy analogues, and their 12-methyl quaternary salts were prepared by a multistep route. Cytotoxicities against 55 human cancer cell lines were measured in the National Cancer Institute screen. The quaternary salts of the dimethoxy compounds (15b/c) were clearly the most active overall, with a mean graph midpoint (MGM) value of 2 m.


The way a particular discipline becomes established and how it evolves has as much to do with institutional and governmental politics, social constructs and pedagogical methodologies, as it does with the discipline itself. It seems that in the degrees of the interdisciplinary subject area of music technology, we see an example of interdisciplinary things to come. We see a collection of academic and professional communities evolving and sometimes clashing in the evolutionary and culturally ingrained tendency in academia to standardize methodology and terminology. We see the movements of sub-disciplines moving apart and regrouping and
sometimes creating new single disciplines within new boundaries. And this movement is governed by different outside factors such as government policies, the Research Assessment Exercise, or the Further and Higher Education Act of 1992.

This poster talk presented the results from the quantitative study of the Palatine (Higher Education Academy) funded project.


This paper dealed with the quantitative relation between the stability of the Rubidium frequency standard and the variations of the amblent temperature and humidity in the clock chamber at URUMQI station,The result of the variance analysis was also presented here


Accurate Hellmann–Feynman force method for the first and second derivatives of energy has been applied to the studies of the chemical reaction systems. We have studied (1) the electronic origins of the structure-reactivity correlations in the reactions CH3 + H CH4 and CH3 + CH3 C2H6 and (2) the geometries and force constants in the reaction intermediate and the transition state of the reactions F− + HF [FHF]− FH + F− and H− + CH4 CH4 + H−, respectively. An intuitive simplicity of the underlying concepts of the first and second derivatives of the present approach is shown in the analysis.


The resettlement of nomads recently has become a renewed topic of interest within the literature on development. The general purpose of most schemes is to sedentarise nomadic peoples through farm or manufacturing co-operatives to be able systematically to provide them with the necessities of existence, including health services and education, and to reduce their vulnerability to the vagaries of their day-to-day search for green pastures and water. Nomadism has been defined as 'the movement of the household during the annual round of productive activities', while its polar opposite, sedentism, is 'the immobile location of the household during the annual round of productive activities'.1


In this technical note, the post-buckling behavior of a simply supported elastic column with various rotational end conditions of the supports is investigated. The compressive force is applied at the tip of the column. The characteristic equation for solving the critical loads is obtained from the boundary value problem of linear systems. In the post-buckling state, a set of nonlinear differential equations with boundary conditions is established and numerically solved by the shooting method. The interesting features associated with this problem such as the limit load point, snap-through phenomenon and the secondary bifurcation point will be highlighted herein.


In light of recent publications relating to resuscitation and pre-hospital treatment of patients suffering acute myocardial infarction the British Heart Foundation convened a working group to prepare guidelines outlining the responsibilities of general practitioners, ambulance services, and admitting hospitals. The guidelines emphasise the importance of the rapid provision of basic and advanced life support; adequate analgesia; accurate diagnosis; and, when indicted, thrombolytic treatment. The working group developed a standard whereby patients with acute myocardial infarction should receive thrombolysis, when appropriate, within 90 minutes of alerting the medical or ambulance service - the call to needle time. Depending on local circumstances, achieving this standard may involve direct admissions to coronary care units, "fast track" assessments in emergency departments, or pre-hospital thrombolytic treatment started by properly equipped and trained general practitioners.

In 1989 a working group of the British Heart Foundation published recommendations for the early management of patients with suspected acute myocardial infarction.1 These were felt to be necessary because of the high incidence of coronary events in the population,2 the recognition that most of those dying do so soon after the onset of symptoms (before arriving in cardiac care units),3 and because many lives could be saved by the prompt provision of resuscitation skills and equipment and, where appropriate, by early thrombolytic treatment.4

The 1989 report needed revision for two reasons: because of the subsequent publication of relevant studies and to address continued uncertainty, not so much about the aim of treatment, but about the role of the various components of the health service (general practitioners, ancillary staff, ambulance services, admitting hospitals) in achieving these aims. A rapid and effective response to heart attack has been targeted as a major health gain area by the Department of Health,5 and health districts have been recommended to …


With the extraordinary growth of cores and threads in today's multithreaded machines, analyzing and tuning the performance of such platforms becomes a challenging task. In this paper, we propose an intuitive and visualizable model for analyzing the performance of contemporary highly concurrent multithreaded machines. Based on flow balancing between service demand and service supply of the memory system, the model draws an intuitive figure to characterize machine state, identify bottlenecks and determine optimization directions. The tractability of the model is highlighted as it only requires two parameters from the workload. Our model achieves 90% and 83% prediction accuracy for computation throughput on Fermi and Kepler GPUs over the 16 applications from Rodinia benchmark.


The shipborne long range acoustic system utilizes ship as the platform. It can broadcast at long range and drive out people at close quarters. For the system,it is important to analyze the distance of broadcasting and driving out. In allusion to mission's require of the shipborne long range acoustic system,the minimum sound pressure level for effective voice broadcasting and driving out is established. On the basis of these research results,the method for the technical indexes such as maximum at 1 meter and maximum power of the system is established,which is very important for the system design.


The field of radiation oncology has moved away from a generalistic radiotherapy practice to a number of specialized areas where radiation oncologists have broadened their knowledge outside the field of radiation oncology per se to be a better partner in multidisciplinary teams. Most radiation oncologists in the larger centers nowadays have only one or two areas of expertise (commonly around brain, head & neck, breast, lung, upper GI, lower GI, urogenital, gynecology, hematology, palliation, etc.). In these areas, radiation oncologists can be better counterparts for the organspecialists, which have often left all the non-oncological work in their specialty to other colleagues. With 2-3 areas of expertise per radiation oncologists and accounting for sufficient back-up, the minimum size of a department treating all categories of patients should be around 8 radiation oncologists. Based on 250 new patients per radiation oncologist and about 500 new patients per linac, the minimum size of a department which covers all areas of expertise should be 4 linacs. This size will also allow physicists and therapists to specialize, although at a size of 6-8 machines, this opportunity may be even better. A minimum size also makes investments of specialized equipped within the department, such as CT, PET-CT or MRI feasible and makes it easier to accommodate machine breakdown or replacement. The economic lifetime of a linac is generally around 10-12 years. Since the pace of technical innovation is much faster, a department with 4-8 linacs has the opportunity to install the latest technology every 2-3 years. This, in combination with a larger physics group, will allow earlier implementation of new treatments. In Europe, the median size of a radiotherapy department is between 2 and 3 linacs, with on average more than 4 linacs per department in only 6 countries. Sufficiently sized departments are also better equipped for research and moving the field forward. The multidisciplinary setting and available infrastructure in larger departments will help to work off the beaten track. Studies in various tumor sites have shown that outcome for patients treated in highly accruing (often larger) centers is better. However, there is probably also a maximum size. For patients, entering a mega-department can be intimidating and beyond a certain size, no further benefits may exist. In addition, geographical circumstances should be taken into consideration. It is well known that easy access to care is related to use of radiotherapy. In more remote areas, satellite centers may be an alternative, especially if infrastructure and staffing can be shared and allow for similar protocols and expertise. Especially where resources are limited, a close collaboration between centers may further improve health care. A possible disadvantage of subspecialization could be that highly specialized radiation oncologists may lose their overview of the developments in the radiotherapy arena and the transfer of new ideas and solutions from one indication to another may be reduced. For that reason, radiation oncologists working with one leg in the tumor-specific field, should keep their other leg in the radiation oncology field.


0. Introduction. In a problem on surface area the writer and Helsel were confronted with the following question. Can a Lipschitzian transformation from a set in a Euclidean three-space into a Euclidean three-space be extended to a Lipschitzian transformation defined on the whole space? The affirmative answer to this question has been given by Kirszbraun. In fact, Kirszbraun shows this result for any Euclidean spaces (see also Valentine). In studying these papers the writer noted that a more general extension problem could be formulated and a different method of proof to the problem could be obtained. To formulate the more general problem we first give some definitions. Let M be a metric space, the distance between two points pu p^ÇzM being denoted by p\pi. Let <P(ildT) be the class of real-valued continuous functions g{t)t 0 ^ / < oo, which satisfy the conditions: (a) g(0) = 0 , (b) g(t) > 0 for / > 0 , (c) for any finite number of points po, pu • • • > pm in M the real quadratic form 2 u i [g(£o£»)+g(/>o£y) ~-#(/>*&•)]&£y is positive. Let g(/)£^P(Jlf). A transformation p*~<j>(p) from a set E in M into a metric space M* will be said to satisfy the condition C(g) on E if, for every pair of points pu p*£E, P*P*^g(pip2), where pt^^ipi), i = l, 2. We shall say that </>(p) can be extended to a set £ ' , EC.E'CM, preserving the condition C(g) if there exists a transformation p*=$(p) from E' into M* which satisfies the condition C{g) on E' and is equal to <f>(p) on E. In this paper we prove the following result. Let M be a separable metric space and let g(J)£<P(ilf). Then any transformation from a set E in M into a Euclidean space which satisfies the condition C(g) on E can be extended to M preserving the condition C(g). We give two examples to illustrate this result. We shall use the vector notation x to represent a point in a Euclidean w-space En, and we shall denote by |#i—x2\ the distance between two points xu #2. Let xQ, XU ' • • , Xm be m + 1 points in En and let £1, ' • • , £ » be m real numbers. From the relation (xi—Xj)~(xo—X{)+(xo—Xj) — 2(xo—Xi)(xo--Xj), the square of the vector x=L£i(x0—#i)+ • • •


Tamarind seed, an abundant agricultural waste, contains a large amount of naturally occurring anti-nutrient, tannin. This study aimed at evaluating the detannification efficiency of tannase producing Bacillus subtilis PAB2 in comparison with enzymatic and conventional physical techniques, and assessment of its health promoting effect in chicken model. Microbial fermentation resulted in lowering of 80.8% tannin, whereas enzymatic and physical treatment removed only 48 and 28.6%, respectively. To assess the health beneficial effects, experimental schedule for poultry chicken model was designed viz., (T1) commercial food, (T2) T1+tamarind seeds, (T3) T1+enzymatic detannified seeds and (T4) T1+ fermented seeds. It was found that physiological indices of chicken in T4 group improved more than T2, but those were comparable with T1 and T3. The level of total plasma protein, albumin and other haematological parameters also significantly (P


This paper focuses on model-based automatic testing environment for Smart Parking Assistance System(SPAS). It is well-known that the SPAS helped inexperienced or elderly drivers by providing partially or fully automatic parking function. Many experiments and simulations for SPAS should be conducted for verifying the control logic on various and different environment. However, it is too hard for the evaluators to modify the environment manually. In this paper, the automatic testing environment that we proposed consists of Test Case Generator, Main GUI environment, and Report Generator. The Test Case Generator makes a file which includes many test cases set by an evaluator. The generated file is loaded by the Main GUI, and the Main GUI controls the vehicle simulator using COM interface. When the all simulation end step by step, the Report Generator makes the test report. Using aforementioned process, we verified the control logic for SPAS. This automatic process can not only reduce the lead time for evaluation, but also increase the efficiency of evaluations.


A new general treatment of the equilibria of complex formation between polymers and multivalent species (e.g. metal cations) is given. The treatment is based on the analysis of the equilibrium in the copolymerization of monomers and their complexes with multivalent species. An example of the analysis of experimental data for complexation of sodium tetraphenylborate with poly(oxyethylene) in methanol is presented.


This study is an evaluation of organisational structure on management effectiveness with reference to Dangote Cement PLC in Gboko, Benue State. The specific objectives were to identify the type(s) of organisational structure adopted in Dangote Cement PLC, Gboko Plant, and its effect on management effectiveness, among others. The research adopted survey research design, the population consist of management personnel of the organisation, which was one hundred and fifty one (151). Purposive and simple random sampling techniques, primary and secondary data was used. Using Taro Yamane's formula, the sample size of the study was used deduce to be one hundred and ten (110), while one hundred (100) questionnaire was well field and return, which formed the basis for the data analysis. Descriptive statistic, Pearson Product Moment Correlation, and Logistic Regression Analysis was used to analyse the objectives. The major findings revealed that; line and staff organisational structure and product/market organisational Structure are organisational structure adopted in the organisation, the correlation analysis result indicated that at P>0.05 level of significance, organisational structure has a strong positive effect on managerial effectiveness with correlation coefficient of (r = 0.811). The Logistic Regression result revealed that; Centralisation (sig≤0.05; w = 2.764), Formalisation (sig≤0.01; w = 11.609), and effective Organisation Communication (sig≤0.01; w = 5.342), are structural variables that are significantly related with the effectiveness of managers in Dangote Cement PLC, Gboko Plant. The researcher concluded that effective organisational structure is sine qua non to management effectiveness and organisational performance, and recommends that organisation structure should be effectively designed for it provides the framework for the activities of the organisation, and its competitive ability.


Measurements of 50‐Hz ac losses were performed using three characteristic NbTi coil samples with ultrafine filaments and a Cu–CuNi mixed matrix at fields up to 1 T and at 4.2 K. Critical current and quenching current densities were measured under dc and ac conditions as well as the losses with their hysteresis and eddy current loss proportions. To characterize the samples by their eddy current loss proportions the transverse resistivity of the matrix ρtrans was determined. The results for losses show that under 50‐Hz ac loads alternating fields up to approximately 1 T are attained without quenching. The fact that the associated eddy current losses of about 105 W/m3 remain comparatively low at 0.5 T and 4.2 K opens up for such structured mixed matrix NbTi composites a novel field of application for superconducting generators and pulsed magnets with 50–60 Hz fed windings.


Soil samples( n = 167) were collected from Xuzhou city,China. The value of magnetic susceptibility and the content of heavy metals( Cu, Zn,Mo,Cd and Pb) were determined. Factorial kriging analysis was applied to investigate spatial variability of magnetic susceptibility and heavy metals at the local( 1 km range) and the regional( 5. 5 km range) scales. Our results indicate that all the variables were influenced by anthropogenic activities( mainly transportation,industry and agriculture) at the local scale. However,their spatial variability at the regional scale is related to soil parent rock. The structural correlations between magnetic susceptibility and the five heavy metals were more significant at the local scale. We therefore conclude that selecting an appropriate sampling interval in this scale is an effective way in improving accuracy of spatial mapping when magnetic susceptibility is used as a proxy for studying heavy metals.


This research is interested in assessing the pros and contras of using an overall continuous versus a disrupted, not overall defined F0 estimate and compare formal and informal speech styles in this regard. During the evaluation we keep in mind the elaboration of an algorithm capable of handling both speaking styles. The approaches are evaluated in an automatic phonological phrasing task, using a formal and informal speech corpus. A phonological phrasing component is a prosodic unit that has its own stress and intonation contour, which may continue in the next unit. For the different speaking styles we use two speech databases: BABEL for formal speaking style and The Hungarian Spoken Language Database for informal speaking style, both in Hungarian language. Three alternatives of F0 post-processing are compared, ranging from a natural F0 contour disrupted at unvoiced places, over a partial interpolation to an overall continuous contour estimation defined for all unvoiced speech segments. Whereas in formal speech, the more continuous the F0 contour is the better detection rates are observed for phonological phrases, for informal speech a partial interpolation of F0, preserving some fragmentation, yields better results. These results also show that discontinuity of F0 can be an important cue in human perception of informal speech, and also means that the idea of trying to de-spontanize spontaneous speech, in order to be able to treat them in the conventional way, seems to be doubtful.


Abstract: A prosthesis (10) has a trunk (12) divided by an internal septum (16) within at least a portion of the trunk interior, a first interior lumen (18), a second interior lumen (20) and a lumen extension component (26) can be sized and configured to be fitted within at least one of the interior lumens.


Abstract Placemaking is a collective process that happens every day. However, little has been written about the ways older African Americans and Latinx immigrants create place in their everyday lives. Less has been said about the ways these efforts are examples of civic participation in the context of systemic inequality and oppression. Results from this phenomenological study that applies an intersectional life course perspective shows how older Black and Latinx immigrant adults maintain, preserve, and build their place in a society that continuously threatens their erasure. These results shine light on the ways Black and Latinx communities work to maintain the physical space (i.e., community safety and sanitation), preserve their culture and history, and build structures to ensure access to resources that will empower their communities. Their efforts across the micro, meso, and macro social environments and across time, demonstrates a concerted effort towards creating a dignified and just place in our society to nourish and sustain future generations.


According to the special requirements of heavy equipments on the pre-stressed steel wires, some properties of the pre-stressed wires, including the fatigue, stress relaxation, creep and erosion have been studied. This results show that the pre-stressed steel wires almost have the limitless lives. The steel wires in tempering state perform are better than in other states on some aspects, including the stress relaxation, normal creep and erosion.


In this paper we develop a nonlinear version of the efficiency-wage competition model pioneered by Hahn (1987). Under the assumption that the strategic relationship among optimal wage bids put forward by competing firms is non-monotonic, we show that market wage offers can display persistent fluctuations. Thereafter, assuming that employers are never constrained in the labour market, we give evidence that in the parameter region of chaotic dynamics, the model is able to reproduce the business cycle regularity according to which average wages fluctuate less than aggregate employment. JEL Classification: C72, E12, E24, J41.


As the application of flyback high-frequency link inverter is increasingly expanded in the field of low power,it is necessary to work out how to efficiently design its core component,flyback high frequency transformer.In combination with the Ap method and empirical formula of the current density,the way to determine the Ap value of a transformer is improved.The complex procedures of the high frequency transformer design are revealed with detailed examples and specific steps.The designed prototype was tested in a 250 VA flyback high frequency link inverter to verify the design effect.The test results show that the transformer works well and the design method is feasible.


Abstract Aging is the leading risk factor for many chronic diseases. Through traditional approaches to drug development and treatment focus on treating one disease at a time, the geroscience hypothesis posits that by targeting fundamental aging processes one could alleviate multiple age-related diseases. Now several geroscience-guided interventions are at the point of entering human clinical trials. To accelerate testing of this important hypothesis, an interdisciplinary Translational Geroscience Network (TGN; R33 AG061456) has recently been established. The TGN is a new national resource of aging research centers committed to working together toward complementary, small-scale, proof-of-concept "use case" clinical studies. One such pilot will be highlighted: a translational trial of senolytics, or drugs targeting the biological aging process cellular senescence in patients with idiopathic pulmonary fibrosis. The promise of geroscience provides another reason "why age matters": by studying the basic biology of aging, we may open novel therapeutic opportunities for challenging age-related diseases.


"I'm no psychiatrist, but if you ask me, politicians in general are pretty insecure people" (O'Brien, 1994, p. 97). This quotation describes politicians as insecure people, and the word "insecure" has more than one implication. It may mean that politicians are insecure to themselves or to people around them. It can also mean that politicians' actions are not trustworthy. This description indicates that one must fear or be aware of politicians in general. A politician's wife may need also to have this caution. According to such description, does a politician's wife feel happy or secure with her husband? This paper will focus on the life of two wives. The first one is Marina Oswald in Don Delillo's novel Libra (1988), and Kathleen Wade in Tim O'Brien's novel In the Lake of the Woods (1994).The main blame would be on husbands; however, this paper will explain the role of the wives as well. The absence of real communication, besides the extreme political expectations of the two husbands, leads to ending the two marriages unsuccessfully.


Sulfonamides (SAs) are low-cost synthetic antimicrobials widely used in veterinary and human medicine to treat diseases and prevent infections. However, long periods of exposure to sulfonamides can cause adverse effects such as allergic reactions. This work aims to study dispersive solid-liquid microextraction as an alternative method for extracting total SAs in meat samples. The procedure uses a colorimetric reaction based on the formation of a pink compound (imine salt) to determine total sulfonamides (sulfamethazine, sulfadimethoxine, sulfathiazole) with digital measurements. A linear response was observed between 33-233 μg kg-1 for total sulfonamides, and the coefficient of variation (n = 11; 67 μg kg-1 of total SAs) and the limit of detection were estimated to be 0.63% and 10 μg kg-1, respectively. For a 750 mg meat sample, 0.11 mg of 4-dimethylaminocinnamaldehyde, 2.60 mg of sodium dodecyl sulfate, and 275 μL of 1-butanol were consumed per sample, and consequently, generating only 335 μL of residue. Besides this, addition-recovery tests were performed, resulting in a 71-100% recovery range, indicating the trueness of the proposed method.


The temporal self-reconstruction of pulsed Bessel-like needle beams was studied. Arrays of nondiffracting sub-7-fs needle beams were shaped from Ti:sapphire oscillator pulses by programming multiple axicons in a phase-only spatial light modulator. Defined distortions in the time domain were induced by local spectral filtering. By differently shading parts of selected sub-beams, the self-reconstruction was analyzed under variable conditions. Pulse duration maps were measured with two-dimensional second order autocorrelation based on the Shack-Hartmann sensor principle of wavefront division. Completely distorted pulses were found to have a pulse duration of > 13 fs whereas partially distorted sub-beams returned to pulse durations close to the initial ones. Specific applications are proposed.


This paper describes a methodology for obtaining a cost model of the form: C/sub A/=C/sub A/(A) where C/sub A/ is the Life Cycle Cost of a proposed weapons system (i.e. the present value of the future expected cost of the system over ifs life expectancy), and A is the total units purchased of the proposed system. The final functional form is likely to be either a linear function of the total units purchased or a 2nd degree polynomial. The purpose of the Life Cycle Cost Model is to enable the analyst to obtain such a functional form at a very early stage in the development of the proposed system. This can aid an analyst to perform a trade off study of several alternate systems at a very early stage in the procurement process.<<ETX>>


Abstract This paper studied the dynamic model of Variable Speed Control Moment Gyros (VSCMG) with uncertainty. The configuration uncertainty and the rotator's inertia uncertainty are introduced into the dynamic model; the effect of uncertainties is also discussed. A new Jacobian matrix is defined to describe the effect of uncertainties. Compared with the traditional definition, this new definition includes the information of installation angle and rotator's inertia. A new steering law is designed based on singularity value decomposition theory. The linearization of dynamic model is discussed and an adaptive parameter estimation method is then proposed to deal with the parameter uncertainty. Monte Carlo approach is used for the simulation. The results show that the proposed parameter estimation method could reduce the output torque error effectively. In the same time, the estimation value can reach to its actual value quickly. It means that the proposed method could counteract the effect of uncertainties, which makes the system dynamics and output torque character dissatisfied, and the system performance is guaranteed.


Abstract We conducted a blinded, case‐control, retrospective study in pediatric patients hospitalized at The Children's Hospital, Denver, Colorado, to determine whether human coronavirus (HCoV)–NL63 infection is associated with Kawasaki syndrome (KS). Over the course of a 7‐month period, nasopharyngeal‐wash samples from 2 (7.7%) of 26 consecutive children with KS and 4 (7.7%) of 52 matched control subjects tested positive for HCoV‐NL63 by reverse transcription–polymerase chain reaction. These data suggest that, although HCoV‐NL63 was circulating in children in our community during the time of the study, the prevalence of infection with HCoV‐NL63 was not greater in patients with KS than in control subjects.


The aim of this book is the analysis of the control theory of the class of rigid robot manipulator systems. Due to the intensive interest that has taken this class of nonlinear systems, a survey on the different approaches used in building control systems for robot manipulators is presented. The main interest of this work is to present in a simpler and a didactic manner a collection of the more recent and illustrative control algorithms developed for robot manipulators systems.


On this PhD thesis we developed a methodology for evaluating the robustness of SUV measurements based on MC simulations and the generation of novel databases of simulated studies based on digital anthropomorphic phantoms. This methodology has been applied to different problems related to quantification that were not previously addressed. Two methods for estimating the extravasated dose were proposed andvalidated in different scenarios using MC simulations. We studied the impact of noise and low counting in the accuracy and repeatability of three commonly used SUV metrics (SUVmax, SUVmean and SUV50). The same model was used to study the effect of physiological muscular uptake variations on the quantification of FDG-PET studies. Finally, our MC models were applied to simulate 18F-fluorocholine (FCH) studies. The aim was to study the effect of spill-in counts from neighbouring regions on the quantification of small regions close to high activity extended sources.


An image processing device for converting an input image into an output image whose blur is reduced. The image processing device includes a first image extracting section that extracts a plurality of pixels composed of a pixel of the input image corresponding to a pixel of interest in the output image and predetermined pixels surrounding the pixel of the input image. A first feature quantity calculating section calculates a first feature quantity from the plurality of pixels extracted by the first image extracting section. A second pixel extracting section extracts a plurality of pixels composed of the pixel of interest and predetermined pixels surrounding the pixel of interest from the input image. A predicting section then generates a pixel value of the pixel of interest.


Abstract Statistical data have become increasingly important with the past 20 years showing rapid growth in several areas, particularly in the production of general-purpose statistics. Despite these advances, the author contends that statisticians have largely failed to apply their skills to measuring demand for, and supply of, statistical data. Recommendations are offered for reducing this neglect and encouraging a new comprehensive treatment of the subject.


e14031^ Background: Palliative X monotherapy of mCRC is generally tolerated by elderly, and/or medically unfit pts. Epidermal growth factor receptor (EGFR) inhibitors improve efficacy when added to combination chemotherapy for mCRC. It is unknown whether biologic agents add benefit to alone in pts who either opt against, or are not candidate for, combination chemotherapy. We conducted a randomized phase II trial to investigate the novel "all-oral" combination of low-dose X and E in this pt population.

METHODS
Eligible pts with mCRC were either deemed unfit for, or chose against, 1st-line combination chemotherapy. Pts were randomized to X (1000 mg/m2 PO BID x 14 days) alone or in combination with E (150 mg PO OD) on a 3-week schedule. A 3rd arm (E alone) was ineffective, and discontinued after a preplanned interim analysis. Imaging was performed every 9 weeks until progression. Primary endpoint was time to disease progression (TTP); secondary endpoints included: objective response rate (ORR), overall survival (OS), safety and quality of life.

RESULTS
From June 2004 to June 2008, 95 pts [median age: 67; range 40-84; ECOG PS: 0 (45pts), 1 (38 pts), or 2 (22 pts)] were randomized to X alone (40 pts), XE (42 pts), or E alone (13 pts). KRAS status, where possible, was analyzed for pts in the first 2 arms only. As compared to X alone, XE was associated with significantly more Gr 3+ toxicity: (diarrhea: 29% vs 5%; fatigue: 12% vs 0%; anorexia 7% vs 0%; stomatitis 7% vs 0%). One pt discontinued treatment in the X arm vs 2 in XE. There was 1 toxic death in XE. TTP was not different for the whole trial (X=7.9 m, XE=9.2 m; p=0.8897), but exploratory subgroup differences emerged (below).

CONCLUSIONS
The addition of E to X is associated with additional toxicity. E may benefit pts with KRAS-wild-type CRC and may harm those with KRAS-mutated CRC. Further study of XE in elderly/unfit pts with KRAS-wild-type CRC is warranted. Supported by grant from Roche. [Table: see text].


Phthalates (PAEs) are widely used as plasticizers in medical devices to make polyvinyl chloride flexible and soft. However, PAEs can be leached out from plasticizers undesirably and can migrate within the material over the time and can end up with direct exposure to humans, because PAEs are not chemically bound, Particularly, (2-ethylhexyl) phthalate (DEHP) is present within various industrial and domestic goods along with medical devices. Leaching of PAEs is the main concern for human health due to toxic health effects, such as endocrine disruptor (EDCs) carcinogenicity, breast cancer, asthma, allergies and so on. PAEs are produced all over the world around 6.0 million metric ton per PAEs expose specifically from plastic containers, like cooler, plastic bottles, soft drinks, mineral water bottles and baby feeders and medical devices. study the leaching of PAEs from medical devices abundantly use in local hospitals. After market survey in first step, infusion (IF) bottles of various brands available for infusion of dextrose, normal saline and mannitol packed in plastic bags/ packing along with this catheters and syringes were collected and coded to fulfill ethical requirements. Total 30 samples (103) of IF, 9 (3x3) samples of catheters along with 3 samples of syringes were collected and analyzed. The IF samples were classified on the basis of their composition, such as sugar (glucose/mannitol) and salt. Leached PAEs were extracted with dichloromethane following (EPA) standard method (606). Moreover DSC analysis showed clear Tg and Tm values for the infusion bottles, which lies in the category of amorphous nature. In addition IF bottles catheters and syringes were also analyzed by FTIR characterization. Results indicated that all IF solutions were acidic with pH ranges from 2.34 to 5.88. Gas chromatographic analysis showed that extent of leaching was different among brands; normal saline showed more PAEs leaching (78.60 µg/L) followed by dextrose (34.29 µg/L), mannitol (20.93 µg/L). In addition leaching studies of catheters was carried out with synthetic saline solution; results showed the total PAEs leached were in the range of 3.96 to 51.484 µg/L. In syringes PAEs leaching was not detected by Gas chromatography. catheters additional 2 PAES i.e DiBP and DiProP. The Overall study indicated that due to medical devices such as infusion solutions, human are at direct exposure risk of phthalate accumulation. Dipropyl Phthalate; Dibutyl Phthalate; Phthalate; BBP: Benzylbutyl Phthalate; Phthalate; Phthalate;


Six alloys have been selected as candidate container materials for the storage of high-level nuclear waste at the proposed Yucca Mountain site in Nevada. These materials are Type 304L stainless steel (SS), Type 316L SS, Incoloy 825, P-deoxidized Cu, Cu-30%Ni, and Cu-7%A1. The present program has been initiated to determine whether any of these materials can survive for 300 years in the site environment without developing through-wall stress corrosion cracks, and to assess the relative resistance of these materials to stress corrosion cracking (SCC). A series of slow-strain-rate tests (SSRTs) jn simulated Well J-13 water which is representative of the groundwater present at the Yucca Mountain site has been completed, and crack-growth-rate (CGR) tests are also being conducted under the same environmental conditions.


This paper proposes a new multiple-valued debiasing method for extracting uniform random binary responses from physically unclonable functions (PUFs). The proposed method handles PUF responses as quaternary values and extracts the corresponding binary responses in a stable and ef?cient manner. Two experiments were conducted to evaluate the stability and effectiveness of the proposed method with simulated and actual responses of the latch PUFs. The results show that the debiased, random binary responses obtained using the proposed method were 55--128% longer than those obtained using conventional best methods.


—In this paper, we model a distributed system consisting of n processes by a respective set of n Communicating Finite State Machines (CFSMs). The processes run concurrently and communicate with each other to accomplish a common goal. As opposed to the traditional product automaton built from the specified CFSMs, whose state-space explodes, we build a compressed model of what are defined as Communicating Minimal Prefix Machines (CMPMs) by simulating the CFSMs concurrently in parallel. The states of CMPMs form a well-founded, partial order. This model can be used to perform reachability analysis of the given system to check the safety properties such as communication deadlocks. The algorithm to generate the CMPMs model from CFSMs is presented in pseudo-code and its complexity discussed.


Based on the basic psychological principles about people's interests in studying,this article discusses how to stimulate and enhance students' interest in learning by well organizing the teaching of engineering materials course,including effective teaching of the introduction lesson,creating situations of question discussion in every class,properly arranging and designing the course's comprehensive experimental training,enhancing students' awareness of engineering,and properly questioning students in class by controlling the difficulty of questions.The teaching of engineering materials course has been more effective in this way.


The authors research 3029 people of the both sexes living in South Western region of Balkan's peninsula according to their blood group systems ABO and Rhesus belongings. The observed people are divided in 5 nationalities Montenegros, Vlahs, Macedonians, Greeks and Albanians. The statistical analysis by standard shows that there are significant differences in blood group system's distribution (K=16, p<0,001, γ2= 41,6908) so as in Rhesus factor's (K=4, p<0,001, γ2= 22,9656). These results are based specialty to predominance frequency of the blood group 0 in Greeks and Albanians and a lower percentage of the negative Rhesus factor in Vlahs (6.39%) and Greeks (9.71%).


The development and implementation of a strategic partnership concept of territorial planning in the short, medium and long term, as well as the identification of appropriate geospatial solutions, are key factors underpinning regional policy implementation needed to ensure the framework for the development of a sustainable and balanced development region.A four years long observation and analysis of planning and regional development within the Central Regional Development Agency lead to elaborating a strategy related to the current needs and trends in regional development. The starting point of the work consisted of an analytical review of the strategic and programmatic documents at the European, national and regional levels, as well as of the written literature in the field of regional planning and development, socio(economic development, and sustainable development. A regional strategic planning and development concept was developed based on the effective use of the Geographic Information Systems technology, a modern, dynamic and complex form of integration of geospatial solutions developed through the implementation of six support projects.


This paper is about the proof of axiomtic indepehdence of the propositional calculas.We produced a law for the arithematio explanation and prooved the three propositional ccaulas Axiontic indepandence with this law.


The new law regulating pregnancy interruption in England, which took effect April 27, 1968, is discussed. Medical and eugenic indications ar e recognized in the new law, and the social indication is indirectly admitted, but the "ethical" indication is not included. A conscience clause is included for persons who may be called upon to participate in the operation. The requirement of registering all induced abortions results in breaches of physician-patient confidentiality which pose considerable ethical problems. In the period April, 1968-February, 1969 33,000 abortions were performed, 24,000 for medical indications. In 750 cases the patient was under 16 years of age. The social indication (risk to other children in the family) was invoked in about 1200 cases.


Condensation phenomena are ubiquitous in nature and are found in condensed matter, disordered systems, networks, finance, etc. In the present work we investigate one of the best frameworks in which condensation phenomena take place, namely, the sum of independent and fat-tailed distributed random variables. For large deviations of the sum, this system undergoes a phase transition and shifts from a democratic phase to a condensed phase, where a single variable (the condensate) carries a finite fraction of the sum. This phenomenon yields the failure of the standard results of the Large Deviation Theory. In this work we exploit the Density Functional Method to overcome the limitation of the Large Deviation Theory and characterize the condensation transition in terms of an order parameter, i.e. the Inverse Participation Ratio (IPR). This procedure leads us to investigate the system in the large-deviation regime where both the sum and the IPR are constrained, observing new phase transitions. As a sample application, the case of condensation phenomena in financial time-series is briefly discussed.


Use of at least one polyol (P) selected from polyester-polyols and polyether-grafted with chains of at least one of polystyrene, polyacrylonitrile and copolymers of styrene and acrylonitrile and the polyester-and polyether polyols into which is dispersed at least one of polystyrene, polyacrylonitrile and copolymers of styrene and acrylonitrile, as used in the formulation of the polyol component or the polyol component of a polyurethane polyamine forming the polymer matrix a flexible cellular material resistant to hydrolysis, said one or more polyols (P) representing at least a portion of said polyol component or at least a portion of the polyol portion of said polyol component polyamine.


China has begun to build eight 10-million-kilowatt wind power bases and the wind power can reach 230 GW of installed capacity by 2020. Such large-scale integration of wind power will have significant impacts on the power system, such as increasingly outstanding difficulties of peak load regulating, the bottleneck of grid integrating capability, and so on. But keeping view of geographically dispersed wind energy resources in a larger scope or even countrywide scope may be an effective way to solve those above problems. In this case, due to the spatiotemporal complementarities of dispersed wind generation, electricity power from wind energy changes slowly, thus to benefit the safe and economic operation of the power system. Hence, based on real wind data which is provided by the China Meteorological Administration (CMA), this paper investigates the impacts of the complementary effect of countrywide dispersed wind energy on the power system. Both short term and long term effects of wind power on the power system are investigated. The results show that the countrywide complementary effect of dispersed wind energy resources could bring various benefits to operation of China electricity system. (10 pages)


1. Background The cacao plantations are generally considered as a sustainable type of business, due to its large international market, which involves various industries such as food and confectionary manufacturers (Tan, 2017). Cacao is not only economically sustainable product, but as well socially and ecologically sustainable crop to help farmers develop the intercropping farm (VECO, n.d.). Recently, International Cacao Organization survey found that production in the cacao global market in 2015-2016 declined (Tan, 2017). Accordingly, as the third largest producer of cacao in the world, Indonesia has the opportunity to fulfil the required demand gap by increasing quantity and quality of its cacao production, through empowering smallholder farmers, who own over 90% of cacao plantations in the country (DJP, 2014). The country can support the farmers and stakeholders through different programmes to practice sustainable agriculture. One of applied sustainable agriculture is the climate-smart concept, which involves increasing productivity by fermenting the cacao beans and reducing greenhouse gasses (GHG) emission by using organic fertilisers. This practice has been carried out by some group of farmers in Bali Province. Despite visible benefits from modification the type production, almost half of the farmers endure their traditional approach to agriculture. Immediately after harvesting, they aim at selling their cacao beans to middlemen in order to get quick money, without considering the sustainable market for their product and enhancing their own income (METI, 2015).


The present invention provides a thermosetting resin composition and a copper-clad laminate fabricated with the same. The thermosetting resin composition comprises the following components by weight: thermosetting resin 20-70%, a curing agent 1-30%, an accelerant 0-10%, a silica powder filler 5-70%, core-shell rubber powder 1-15%, and a solvent of an appropriate amount. The silica powder filler is silica powder that is melt and vitrified at a temperature higher than 1800°C and has at least two surfaces in shape. In the core-shell rubber powder, the core is organic silicone resin and the shell is polymethyl methacrylate resin. The average particle size of the core-shell rubber powder is 10-500 nm. The silica powder and core-shell rubber powder added into the thermosetting resin composition of the present invention significantly decrease CTE of the composition material and improve the toughness and heat resistance of the composition material. The copper-clad laminate fabricated with the thermosetting resin composition has good overall performance, heat resistance, and dimensional stability at high temperature, meeting the requirements in processing and assembly of circuit boards.


It has been noted occasionally that a number of large miniatures described in detail in the Exposition des ymages at the beginning of the Belleville Breviary are not actually included in the manuscript. This study is devoted to a reconstruction of their original appearance, drawing conclusions from the description in the expository text, and from the evidence of other works of art. The importance of the Belleville Breviary in the development of 14th-century allegorical and devotional imagery — already recognized from the extant pictorial program of calendar and psalter — is underscored further by the re-integration of the newly reconstructed images into the overall scheme of illustration designed by Jean Pucelle.


Disorders of iron metabolism and homeostatis belong to the most common diseases in humans; however, neither the regulation of iron metabolism in erythroid cells nor the pathophysiology of these diseases are completely understood. Last year we reported at this meeting a case of severe hypochromic microcytic anemia caused by a homozygous mutation in the divalent metal transporter 1 (DMT1) gene ( DMT1 1285G>C ). The defective growth of this patient's erythroid progenitors in vitro was rescued by the addition of 10 μM iron-salicylaldehyde isonicotinoyl hydrazone (Fe-SIH), an iron chelate that has been shown to deliver iron for heme synthesis without involving the transferrin receptor/DMT1 pathway. To further characterize the impact of the DMT1 mutation on the in vitro growth of erythroid progenitors, 10 μM Fe-SIH, 25 μM hemin or 10 μM zinc chloride (ZnCl2) were added to the erythropoietin (Epo) containing cultures. All substances increased the plating efficiency in normal control as well as mutant BFU-Es. Moreover, all substances led to a 1.4 to 1.6 fold increase in hemoglobin (Hb) content in normal BFU-Es. Although hemin did not significantly increase Hb content in the patient's BFU-E, the addition of Fe-SIH to the Epo/hemin-containing cultures increased Hb content 2.2 fold. Since Hb synthesis in heme-deficient erythroid cells is inhibited by heme-regulated inhibitor (HRI) kinase, which specifically phosphorylates the α subunit of the eukaryotic initiation factor 2 (eIF2α), we have analyzed the level of eIF2α phosphorylation in cytospine-harvested BFU-Es. Immunofluorescence analysis of erythroid cells with phospo-eIF2α (Ser51) antibody revealed increased phosphorylation of eIF2α in mutant BFU-Es compared to control BFU-Es grown under all aforementioned conditions. The most striking differences were observed in Epo and Epo/hemin containing cultures, in which the fractions of phospho-eIF2α-positive cells were significantly higher in mutant BFU-Es. These data suggest that the block of terminal differentiation/hemoglobinization in the DMT1-mutant erythroid cells is only partially caused by translational arrest of globin chain synthesis; the delivery of iron may be required for other cellular functions apart from Hb synthesis. Interestingly, the most prominent positive effect on the proliferation (i.e., BFU-E cellularity) as well as hemoglobinization of mutant BFU-Es had a combination of Epo/Fe-SIH and ZnCl2; this combination led to the highest increase in Hb content that was associated with almost complete lack of eIF2α phosphorylation. This suggests that the addition of Zn2+ to Fe-SIH containing cultures further stimulates processes that are initially rescued in DMT1-mutant erythroid cells by the addition of iron. We conclude, that the DMT1 defect in erythroid cells is complex, probably involving the combination of transcriptional and translational defects that cannot be rescued by hemin alone.

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 [1]: pending:yes


concerns 1 about the glycated hemoglobin (HbA1c) measurement in our three robust older women who showed a decline in HbA1c after emergency COVID-19 measures. 2 Their fi rst concern was the laboratory ' s quality control for our HbA1c measurement. The serial analysis of HbA1c value in these three robust older women was performed by a high-quality HbA1c analyzer (HLC-723G11) in our University Hospital. The analysis had suf fi ciently low imprecision coef fi cients of variation (CVs), with repeatability imprecision CVs of 1.0% and 0.6% for low and high HbA1c venous samples and between-day imprecision CV of 0.6% for low HbA1c venous samples, 3 which are compara-ble with, or even lower than the respective imprecision CVs in the report 4 cited in their references. 1 The HbA1c level decreased by 0.3% in each of the three robust older women after emergency COVID-19 measures. 2 Even when adopting the largest error range using venous samples in the report (3.80%), 4 the largest error in the HbA1c decline in our robust older women would be only about (cid:1) 0.01% HbA1c. Thus, their concern about the quality control of our HbA1c measurement is unjusti fi ed. They found an increase in blood viscosity in patients with COVID-19, and expressed a second concern about the in fl u-ence of blood viscosity on HbA1c measurement. 1 However, our three robust older women with unexpected HbA1c decline were, in the fi rst place, not infected with severe acute respira-tory syndrome coronavirus 2 (SARS-CoV-2), but just stayed at during the emergency measures in response to the call by


In this paper we develop a time Scheduling, Subcarrier and Power Allocation scheme for Multi-Service Downlink OFDMA Systems. We propose a two step solution where time scheduling is separated from subcarrier and power allocation decisions. The system is modeled as a linear dynamic system with the aim of minimizing a quadratic cost function. The proposed scheduler is a Linear-Quadratic-Regulator (LQR) which achieves fairness among users by proposing an instantaneous data rate for each user in each time slot. The data rate vector proposed by the regulator is then fed as a constraint to the subcarrier and power allocation problem. This problem is formulated as a constrained convex optimization problem and we develop algorithms for subcarrier and power allocation to achieve the data rates proposed by LQR. Simulation results show good performance and better fairness among users.


Obesity and long‐term exposure to high fat diet (HFD) are both associated with peripheral and central inflammation. Acute HFD exposure, however, is also associated with neuroinflammation in brainstem areas responsible for control of gastric functions and energy homeostasis prior to the development of obesity. Neuroinflammation and astroglial activation are known to modulate neuronal activity and physiological outcomes, such as gastric motility, emptying, and food intake. Following initial HFD exposure and a brief (24hr) period of hyperphagia, both humans and rodent models regulate their caloric intake within 3–5 days. The neuroinflammation observed within the brainstem during acute HFD exposure may, therefore, contribute to the homeostatic regulation of caloric intake. The aim of this study is to test the hypothesis that restoration of energy balance during acute HFD exposure requires brainstem astroglial activation.


Objective To establish a system for evaluating factors having enfluence on cochlear implantation effectiveness.Methods The Delphi's techniques was used in this study.The evaluation questionnaire was sent twice to 70 selected experts in the country.Based on their analyses and judgement,the order and weighing of the content in the questionnaire were ratified with deletions and additions as seen appropriate.Expert response rate,opinion convergence,correlation,degree of authority,and weighing coefficients on questionnaire items were analyzed.Results The response rate was 82.86% and 93.10% for the two rounds of inquiries,respectively.Expert opinions demonstrated reasonable convergence and coherence(P 0.05),allowing determination of weighing coefficient for secondary and tertiary indices.Conclusion With enthusiastic participation by experts,a consensus has been reached regarding appropriate items in a system for evaluating factors having enfluence on children's rehabilitation results from cochlear implantation.In this study,the preoperative general information in the secondary indices and the age of the cochlear implantation in the tertiary indices has been given the highest weighing coefficient,respectively.


The premature failure of asphalt pavement is not only relates to the links before pavement formation such as design and construction,but also has close relation with operation,maintenance and management of pavement after its formation.Therefore,in order to prolong the service life of asphalt pavement and increase investment benefit,every subject such as department of design,construction,supervision,quality inspection and maintenance must shoulder its responsibility,check every links and perform its functions strictly.


: This research is based on the absence of physical fitness test on flag-hoisting ceremony candidates (PASKIBRAKA candidates, henceforth) of Sleman regency in accordance with the samples' age category. In the previous test, the Indonesian Armed Forces (TNI) entrance test was used. The purpose of this research is to find out the level of physical fitness of flag-hoisting ceremony candidates in Sleman using Indonesia Physical Fitness Test (TKJI), so that flag-hosting ceremony candidates can find out their own level of physical fitness. This study was a descriptive research using a method of survey, including test and measurement. The population was 100 PASKIBRAKA candidates, consisting of 50 male and 50 female students. Data of physical fitness level of PASKIBRAKA candidates of Sleman were taken using the measurement of TKJI in 1999 for the age of 16-19 years. A quantitative descriptive analysis with percentage was used in this research as a technique of data analysis. The analysis result showed that from 96 male and female students, the students' physical fitness level with (1) very good category (BS) was 0 %, (2) good category (B) was 16.67 %, (3) medium category (S) was 53,12 %, (4) less category (K) was 29,17 %, and (5) very less category (KS) was 2,04 %.


Stroke‐related restless legs syndrome (sRLS) secondary to ischemic lesions is an emerging entity and an interesting condition, but there are limited available data to help us further understand its underlying pathways. In this study, we characterized sRLS clinically, neuroanatomically and functionally.


The first investigations of the response of the microlensing magnification pattern (at an optical depth of order unity) to the mass function of the microlenses found that the resulting statistics depend only on the mean microlens mass . In particular the mean microlensing caustic crossing rate was found to be proportional to the squareroot of . We show that while this is true in the limit of mass functions with a narrow range of mass, in general the magnification pattern shows structure that reflects the contribution to the optical depth of microlenses with different masses. We present a better approximation, relating the microlens mass function to light-curve statistics. We show that the variability statistics of quasar microlensing light-curves can (in principle) be inverted to obtain the mass function of the microlenses in the mass range over which the mass density remains comparable, ie. p(m)dm~C/m. A preliminary analysis of the structure function for Q2237+0305 suggests that there is not a significant contribution to the optical depth from very low mass objects (0.001 solar mass). However observations of multiple microlensed quasars for a period of ~20 years may in the future yield a detailed p(m)dm. In the mass range where the number density is comparable, ie. p(m)dm~const., the distribution of flux factors could be inverted to find the microlens mass function. This may be used as a probe of the abundance of planets with orbital radii >100 AU.


Abstract
 The linking of climate projections and insect pest models is an important step for determining effective management and counter-measures. There is an urgent need to link pest models and climate change projections for a better understanding of the outcomes of climate change-inflicted variations in future pest status. The present review aims to summarize the insect pest models that have been linked with global circulation model-based climate change scenarios and also provide a reference for future risk evaluation of agriculturally and horticulturally important insect pests. Further, discussions are also included on linking of climatic pattern matching function and process-based climatic response-type models with climate change scenarios for understanding the impact of model selection on pest status. Most simulation models use projected temperature as the main driver to run for pest risk. A total of 29 climatic pattern matching and 19 phenology-based simulation studies for insect pest risk, mainly available from USA, China, Australia, India, New Zealand and Slovenia, met the criterion of linking pest models with climate change projections. Most of the studies considered only one or few GCM-based climate change projections. No study has been simulated with an option of management components. The present review suggests that insect pest modelling for future pest risk should include more GCMs with several climatic factors by also considering the cropping systems of a particular area.


In order to research the inheritance of rice blast (Magnaporthe grisea) resistance of five cultivars to three major races of IB-1,IE-1k and IG-1,four American cultivars,Katy,Mars,LaGrue,and Newbonnet,and one Chinese cultivar,Teging in a complete diallel design was conducted in University of Arkansas at Pine Bluff,USA in 2008 and 2009.The parents,F1 and F2 were inoculated with these three races separately to test blast responses in the greenhouse of Rice Research Center in Stuttgart,Arkansas,USA in 2008 and 2009.Results:Teqing was resistant to all the three races.Katy was resistant to IB-1 and IG-1,but not to IE-1k. Mars was resistant to IE-1k,but susceptible to the other two. LaGrue was susceptible to all the three races.Newbonnet was susceptible to IB-1 and IE-1k,but resistant to IG-1.Experimental data showed six types of segregation ratio in the F2 progenies of the complete diallel crosses:1) 63 R:1 S indicated three dominant genes independently responsible for blast resistance; 2) 15 R:1 S suggested two dominant genes independently responsible for blast resistance; 3) 7 R:9 S suggested two genes working dominantly and complementarily resulting in blast susceptibility; 4) 3 R:1 S fitted in the single dominant gene model controlling blast resistance; 5) 1 R:0 S indicated allelic genes in two resistant parents; 6) 0 R:1 S indicated allelic genes in two susceptible parents.In most cases,resistant gene(s) was dominant over susceptible regardless of parents and blast races with only one exception.Susceptible F1 derived from resistant Mars with susceptible Katy,LaGrue and Newbonnet,respectively,indicated that the resistant gene(s) to race IE-1k in Mars was recessive.The recessive resistant gene model was verified by the segregation ratio of 7 R:9 S in all F2 progenies from those F1 hybrids. Further more,this segregation ratio suggested that the two genes were complementarily involved. No differences of blast segregation between reciprocal crosses from any cultivars to any blast race were observed. Therefore,cytoplasm was not involved in the inheritance of blast in rice.


This paper presents the experimental study on the application of the peg-in-a-hole task in the proposed haptic teleoperation system. Motion references from the user towards the remote manipulator and force feedback signals from the remote environment towards the user are transmitted through a virtual reality layer where the remote operation is simulated in real-tme. Various physical interactions occuring in the bilatral loop are modelled and controlled through the introduction of virtual spring-damper elements. Modeling and controller design of the teleoperation system is made modular and straightforward with the use of identical virtual dynamics. The design approach combines the introduction of the middle layer of virtual reality and modeling of all interactons by identical virtual spring-dampers. The haptic teleoperation system is experimentally evaluated with experienced and unexperienced users in the bilateral loop. Experimental results show that stable peg-in-a-hole operation is achieved in presence of bounded time-delays in all communication channels between the user, virtual reality layer and remote environment. Improvements of the teleoperation performances in terms of position tracking and total operation time are also observed in experiments.


Localization of catecholamines in the nervous system of 12 species of Trematodes parthenitae from marine mollusks has been studied using the method of glyoxilic acid-induced fluorescence. Unlike primitive species with orthogon-like distribution of catecholamines, specialized ones have diffuse nervous plexus, which can be reduced in most specialized forms.


Increasing soybean yields needs to be done with innovation in cultivation techniques, one of which is by applying the right planting time. This study aims to obtain planting time that can increase the growth and yield of soybeans in a system without tillage. The study was conducted from June to September 2019 on the former rice field land. This research was conducted using a Randomized Completed Block Design 1 factor with 5 treatments (2, 4, 6, 8 and 10 days after rice harvest) and repeated 5 times. Data from observations were analyzed using analysis of variance based on the 5% F test followed by Duncan's Multiple Range Test of 5% and a correlation test was performed to determine the relationship between soybean planting time difference and the yield. The results showed that the difference 2 days after harvest was able to increase the growth variables, namely plant height, leaf area, number of branches and increase the yield variable, namely the number of pods, seed weight per plant, seed weight per plot. Besides increasing soybean yield to 1.41 tons / ha compared to a longer gap.